gebhart/patrepeval huggingface dataset:
Grade Adjustment Methods (1993)

The last major review of grade adjustment methods developed to improve the prediction of academic performance is Linn’s 1966 article. Since then, several other statistical methods have been developed and used to make grades from different courses more directly comparable. In several instances, these methods have improved the understanding of the observed phenomena of differential predictive validity for women and for minority students. Each method is based on a different statistical methodology and set of assumptions about the data and tested on a different data set. This article reviews the studies in this area over the past 27 years and discusses this research in the context of selection in admissions and of the prediction of student performance in college.
Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts (1981)

Using monoclonal antibodies and flow cytometry, wer serially monitored lymphocyte subpopulations in renal-allograft recipients treated with either conventional immunosuppression or a monoclonal antibody. In 29 patients given conventional suppression, highly significant correlations between changes in T-cell subsets and rejection were noted. Normal or elevated ratios of OKT4 (helper/inducer) to OKT8 (suppressor/cytotoxic) cells were associated with rejection unless the donor was HLA identical or the total number of T cells was extremely low. In patients with low ratios, rejection seldom occurred. Two patients treated with OKT3 monoclonal antibody for acute rejection had rapid disappearance of OKT3-reactive cells from the peripheral blood and prompt reversal of rejection. The use of monoclonal antibodies allows the precise determination of changes in T-cell subsets and promises the development of therapeutic protocols that can be designed to manipulate selected lymphocyte populations.
Spin-orbit torque and Nernst effect in Bi-Sb/Co heterostructures (2019)

Harmonic measurements of the longitudinal and transverse voltages in Bi-Sb/Co bilayers are presented. A large second harmonic voltage signal due to the ordinary Nernst effect is observed. In experiments where a magnetic field is rotated in the film plane, the ordinary Nernst effect shows the same angular dependence in the transverse voltage as the dampinglike spin-orbit torque and in the longitudinal voltage as the unidirectional spin-Hall magnetoresistance, respectively. Therefore, the ordinary Nernst effect can be a spurious signal in spin-orbit torque measurements, leading to an overestimation of the spin-Hall angle and spin-Hall conductivity in topological insulators or semimetals.
Plasmin-Mediated Activation and Inactivation of Thrombin-Activatable Fibrinolysis Inhibitor (2002)

Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates the fibrin cofactor function of tissue-type plasminogen activator-mediated plasmin formation and subsequently fibrin degradation. In the present study, we focused on the role of plasmin in the regulation of TAFIa activity. Upon incubation with plasmin, TAFIa activity was generated, which was unstable at 37 degrees C. Analysis of the cleavage pattern showed that TAFI was cleaved at Arg(92), releasing the activation peptide from the 35.8-kDa catalytic domain. The presence of the 35.8-kDa fragment paralleled the time course of generation and loss of TAFIa activity. This suggested that, in the presence of plasmin, TAFIa is probably inactivated by proteolysis rather than by conformational instability. TAFI was also cleaved at Arg(302), Lys(327), and Arg(330), resulting in a approximately 44.3-kDa fragment and several smaller fragments. The 44.3-kDa fragment is no longer activatable since it lacks part of the catalytic center. We concluded that plasmin can cleave at several sites in TAFI and that this contributes to the regulation of TAFI and TAFIa.
Imidazoline binding sites on receptors and enzymes: Emerging targets for novel antidepressant drugs? (2003)

Competing interests: None declared.

Correspondence to: Dr. Andrew Holt, Neurochemical Research Unit, Department of Psychiatry, Mackenzie Centre, University of Alberta, Edmonton AB T6G 2R7; fax 780 492-6841; ac.atreblau@tloh.ydna
The design of fast asynchronous adder structures and their implementation using DCVS logic (2002)

New asynchronous adder structures with high performances and low cost have been designed. Previous work has only reported the design of carry-save and carry-ripple asynchronous adders. In this study, we have developed new asynchronous adders, Carry Select Adders, Carry Skip Adders, Carry Look Ahead Adders and we compare their potentialities in terms of speed and complexity. First, the functional properties of the conventional asynchronous carry ripple addition scheme are described so as to introduce the capabilities of asynchronous adders and to show how asynchronous operators can be far more efficient than synchronous ones. Then, starting from the well known architectures previously developed to accelerate the addition operation, we first describe their asynchronous equivalents and then show how they can be optimized to fully exploit the functional and electrical dependencies of the computation process with respect to the data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Patterns of expression of tumor necrosis factor α, tumor necrosis factor β, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy (1996)

JRA and JSpA synovia are characterized by the presence of TNF alpha, TNF beta, and cells expressing TNFR. These findings provide further evidence that TNF, through autocrine/paracrine mechanisms, may amplify local inflammation, leading to joint destruction. The prominence of TNF beta in the synovium in particular subgroups of JRA patients and in JSpA patients may be a distinguishing feature of these diseases.
Synthesis and pairing properties of oligoribonucleotide analogues containing a metal-binding site attached to beta-D-allofuranosyl cytosine (1998)

A method for the facile preparation of oligoribonucleotide analogues containing beta-d-allofuranosyl nucleosides with additional functional groups tethered to the 6'-O positions is presented. It is based on the synthesis of two protected nucleosides carrying a 6'-O -bromopentyl and a 6'-O -methylaminopentyl substituent. By a simple two-step procedure, these key intermediates were transformed into two phosphoramidites carrying a 1-aza-18-crown-6 and a triethyleneglycol group, respectively, each capable of complexing metal ions. By automated synthesis, these functionalized nucleoside analogues were efficiently incorporated into short oligoribonucleotides. Under physiological conditions (150 mM NaCl, 2 mM MgCl2, pH 7.4), incorporation of a single allofuranosyl cytosine substituted with a triethyleneglycol moiety led to a significant enthalpic stabilization of an A-type RNA duplex. This observation is in agreement with a metal ion-mediated stabilizing interaction between the two pairing strands.
ChemInform Abstract: Ether Formation in the Hydrogenolysis of Hydroxymethylfurfural over Palladium Catalysts in Alcoholic Solution. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study of cryostructuration of polymer systems. XV. Freeze-Thaw-induced formation of cryoprecipitate matter from low-concentrated aqueous solutions of poly(vinyl alcohol) (1999)

Freeze–thaw treatment of low-concentrated (<C*) aqueous solutions of poly(vinyl alcohol) (PVA) results in the formation of a cryoprecipitate fraction. It is shown that the efficiency of such a process (the yield of PVA cryoprecipitation) depends on the initial polymer concentration in the solution to be frozen and the conditions of a cryogenic influence. The key factor is defrostation dynamics: The slower the thawing rate, the higher the cryoprecipitation yield. The iodine-staining method is employed for the quantitative analysis of PVA concentrations in the solutions under study and the necessity of the use of reduced (0–2°C) temperatures throughout such a PVA quantification is demonstrated. Observation of the kinetics of the freeze–thaw-induced formation of cryoprecipitate matter reveals the extreme character of the temperature dependence of the efficacy of PVA macromolecule aggregation, the extreme point being situated in the vicinity of −2°C. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 1978–1986, 1999
Transmembrane Auxiliary Subunits of Voltage-dependent Ion Channels (1996)

Auxiliary subunits of voltage-dependent ion channels can be subdivided into two classes. One class consists of the entirely cytoplasmic intracellular subunits, which have no transmembrane domains such as the β subunit of the voltage-dependent Ca2+ channel and the β subunit of the voltage-dependent K+ channel. The other class of auxiliary subunits contains at least one transmembrane domain and an extracellular glycosylated region. This review will concentrate on the transmembrane auxiliary subunits.
HIF1A gene Pro582Ser polymorphism and susceptibility to digestive tract cancers: a meta-analysis of case-control studies (2014)

Many existing studies have demonstrated that common polymorphisms in the hypoxia inducible factor-1α (HIF-1A) may contribute to the development of digestive tract cancers, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a precise estimation of the relationships between HIF1A Pro582Ser polymorphism and the risk of digestive tract cancers. We searched CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through May 1, 2013. Meta-analysis was performed using the STATA 12.0 software. We assessed 6 case-control studies that included a total of 911 digestive tract cancer patients and 2774 healthy controls. Our meta-analysis indicated that HIF1A Pro582Ser polymorphism was associated with an increased risk of digestive tract cancer. Subgroup analysis by ethnicity suggested that HIF1A Pro582Ser polymorphism might increase an individual's susceptibility to digestive tract cancer in Asian populations. However, similar association was not observed in Caucasian populations. In conclusion, our findings suggest that HIF1A Pro582Ser polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
Conductance characteristics of ballistic one-dimensional channels controlled by a gate electrode (1989)

Ballistic one-dimensional channels are fabricated using a highly resistive region induced by focused Ga ion beam scanning. Both wide and narrow channels are fabricated using this process. Transport characteristics of these channels are controlled by a voltage applied to the Schottky electrode on the channel. The channels show multiple-step structures in their transport characteristics at low temperature when the gate voltage is varied. This is probably due to the ballistic transport through one-dimensional quantized electron states. For narrower channels, the number of the observed steps becomes fewer. Instead, the structures are observable at higher temperature.
Tunable Filters Using Ultrawide-Band Surface Acoustic Wave Resonator Composed of Grooved Cu Electrode on LiNbO3 (2010)

A leaky surface acoustic wave (LSAW) with a leaky component on a 0–15°YX-LiNbO 3 substrate has a large electromechanical coupling factor. In order to change the LSAW to a Love wave without a leaky component, a high-density electrode with a low velocity such as a Au or Cu electrode is composed on the substrate. A SAW resonator with a Cu-electrode/15°YX-LiNbO 3 structure has been reported to have a wide bandwidth of 12%. In this study, in order to obtain a SAW resonator with a wider bandwidth for application to tunable filters, the authors fabricated one-port resonators with a grooved Cu-electrode/4°YX-LiNbO 3 structure. This resonator had a 1.3-fold wider bandwidth of 17% and 1.3-fold higher resonant and antiresonant frequencies than a conventional resonator composed of the same thick Cu-electrode on 4°YX-LiNbO 3 fabricated for reference. Moreover, the authors proposed the application of this resonator to a tunable filter by using a circuit to modify a conventional band-pass filter composed of inductors and capacitors (LC) and a tunable filter with a ladder-type circuit. As a result, tunable filters having tunable ranges of 7 and 9% at the center frequency and 3 dB bandwidths of 3 and 5%, respectively, have been realized.
3D-MLSI: software package for inductance calculation in multilayer superconducting integrated circuits (2001)

A new software package 3D-MLSI was developed for inductance calculation in multilayer superconducting integrated circuits. The key advantages of 3D-MLSI are: a new mathematical model that takes into account the 3D distribution of magnetic field, and a user interface compatible with the Cadence and ACAD design tools. The program is most applicable when both kinetic and magnetic inductances are important. A method of equivalent circuits inductance extraction is suggested.
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. (1998)

The ability to regulate specific genes of energy metabolism in response to fasting and feeding is an important adaptation allowing survival of intermittent food supplies. However, little is known about transcription factors involved in such responses in higher organisms. We show here that gene expression in adipose tissue for adipocyte determination differentiation dependent factor (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and elevated upon refeeding; this parallels closely the regulation of two adipose cell genes that are crucial in energy homeostasis, fatty acid synthetase (FAS) and leptin. This elevation of ADD1/SREBP1, leptin, and FAS that is induced by feeding in vivo is mimicked by exposure of cultured adipocytes to insulin, the classic hormone of the fed state. We also show that the promoters for both leptin and FAS are transactivated by ADD1/SREBP1. A mutation in the basic domain of ADD1/SREBP1 that allows E-box binding but destroys sterol regulatory element-1 binding prevents leptin gene transactivation but has no effect on the increase in FAS promoter function. Molecular dissection of the FAS promoter shows that most if not all of this action of ADD1/SREBP1 is through an E-box motif at -64 to -59, contained with a sequence identified previously as the major insulin response element of this gene. These results indicate that ADD1/SREBP1 is a key transcription factor linking changes in nutritional status and insulin levels to the expression of certain genes that regulate systemic energy metabolism.
Sur la constitution de la charge électrique à la surface d'un électrolyte (1910)

Pas de Résumé disponible
Netscape communicator's collapsible toolbars (1998)

Article Free Access Share on Netscape communicator's collapsible toolbars Authors: Irene Au Client User Experience Group, Netscape Communications Corp., 501 E. Middlefield Rd. MV-054, Mountain View, CA Client User Experience Group, Netscape Communications Corp., 501 E. Middlefield Rd. MV-054, Mountain View, CAView Profile , Shuang Li Client Visual Design Group, Netscape Communications Corp., 501 E. Middlefield Rd. MY-054, Mountain View, CA Client Visual Design Group, Netscape Communications Corp., 501 E. Middlefield Rd. MY-054, Mountain View, CAView Profile Authors Info & Claims CHI '98: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsJanuary 1998 Pages 81–86https://doi.org/10.1145/274644.274657Published:01 January 1998Publication History 1citation199DownloadsMetricsTotal Citations1Total Downloads199Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A New Statistic for Detecting Genetic Differentiation (2000)

A new statistic for detecting genetic differentiation of subpopulations is described. The statistic can be calculated when genetic data are collected on individuals sampled from two or more localities. It is assumed that haplotypic data are obtained, either in the form of DNA sequences or data on many tightly linked markers. Using a symmetric island model, and assuming an infinite-sites model of mutation, it is found that the new statistic is as powerful or more powerful than previously proposed statistics for a wide range of parameter values.
Comparative Study of Influenza Virus Replication in MDCK Cells and in Primary Cells Derived from Adenoids and Airway Epithelium (2012)

Although clinical trials with human subjects are essential for determination of safety, infectivity, and immunogenicity, it is desirable to know in advance the infectiousness of potential candidate live attenuated influenza vaccine strains for human use. We compared the replication kinetics of wild-type and live attenuated influenza viruses, including H1N1, H3N2, H9N2, and B strains, in Madin-Darby canine kidney (MDCK) cells, primary epithelial cells derived from human adenoids, and human bronchial epithelium (NHBE cells). Our data showed that despite the fact that all tissue culture models lack a functional adaptive immune system, differentiated cultures of human epithelium exhibited the greatest restriction for all H1N1, H3N2, and B vaccine viruses studied among three cell types tested and the best correlation with their levels of attenuation seen in clinical trials with humans. In contrast, the data obtained with MDCK cells were the least predictive of restricted viral replication of live attenuated vaccine viruses in humans. We were able to detect a statistically significant difference between the replication abilities of the U.S. (A/Ann Arbor/6/60) and Russian (A/Leningrad/134/17/57) cold-adapted vaccine donor strains in NHBE cultures. Since live attenuated pandemic influenza vaccines may potentially express a hemagglutinin and neuraminidase from a non-human influenza virus, we assessed which of the three cell cultures could be used to optimally evaluate the infectivity and cellular tropism of viruses derived from different hosts. Among the three cell types tested, NHBE cultures most adequately reflected the infectivity and cellular tropism of influenza virus strains with different receptor specificities. NHBE cultures could be considered for use as a screening step for evaluating the restricted replication of influenza vaccine candidates.
Three novel and one C31133T (Arg-338-->Stop) mutations of antihemophilic factor IX gene detected in Taiwan. (1996)

The G to C mutation at nt 118 creates an Alu I restriction site and the C to T mutation at nt 31133 abolishes a Taq I site. Therefore, familial survey and rapid prenatal diagnosis for these patients by PCR-based direct sequencing method or by the restriction of enzyme cutting method pointing at the known mutation sites are certainly possible to achieve in our patients.
Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells (2009)

Inhibitory-cell killer immunoglobulin-like receptors (KIR) negatively regulate natural killer (NK) cell-mediated killing of HLA class I-expressing tumors. Lack of KIR-HLA class I interactions has been associated with potent NK-mediated antitumor efficacy and increased survival in acute myeloid leukemia (AML) patients upon haploidentical stem cell transplantation from KIR-mismatched donors. To exploit this pathway pharmacologically, we generated a fully human monoclonal antibody, 1-7F9, which cross-reacts with KIR2DL1, -2, and -3 receptors, and prevents their inhibitory signaling. The 1-7F9 monoclonal antibody augmented NK cell-mediated lysis of HLA-C-expressing tumor cells, including autologous AML blasts, but did not induce killing of normal peripheral blood mononuclear cells, suggesting a therapeutic window for preferential enhancement of NK-cell cytotoxicity against malignant target cells. Administration of 1-7F9 to KIR2DL3-transgenic mice resulted in dose-dependent rejection of HLA-Cw3-positive target cells. In an immunodeficient mouse model in which inoculation of human NK cells alone was unable to protect against lethal, autologous AML, preadministration of 1-7F9 resulted in long-term survival. These data show that 1-7F9 confers specific, stable blockade of KIR, boosting NK-mediated killing of HLA-matched AML blasts in vitro and in vivo, providing a preclinical basis for initiating phase 1 clinical trials with this candidate therapeutic antibody.
Aluminum Exposure in Neonatal Patients Using the Least Contaminated Parenteral Nutrition Solution Products (2012)

Aluminum (Al) is a contaminant in all parenteral nutrition (PN) solution component products. Manufacturers currently label these products with the maximum Al content at the time of expiry. We recently published data to establish the actual measured concentration of Al in PN solution products prior to being compounded in the clinical setting [1]. The investigation assessed quantitative Al content of all available products used in the formulation of PN solutions. The objective of this study was to assess the Al exposure in neonatal patients using the least contaminated PN solutions and determine if it is possible to meet the FDA &#8220;safe limit&#8221; of less than 5 &#956;g/kg/day of Al. The measured concentrations from our previous study were analyzed and the least contaminated products were identified. These concentrations were entered into our PN software and the least possible Al exposure was determined. A significant decrease (41%&#8211;44%) in the Al exposure in neonatal patients can be achieved using the least contaminated products, but the FDA &#8220;safe limit&#8221; of less than 5 &#956;g/kg/day of Al was not met. However, minimizing the Al exposure may decrease the likelihood of developing Al toxicity from PN.
Facile One-Pot Synthesis of 6-Monosubstituted and 6,12-Disubstituted 5,11-Dihydroindolo[3,2-b]carbazoles and Preparation of Various Functionalized Derivatives (2007)

A facile three-stage, one-pot approach for the synthesis of a variety of novel 6-monosubstituted and 6,12-disubstituted 5,11-dihydroindolo[3,2-b]carbazoles, in moderate to good yields (20-50%), has been developed, based on the condensation of an indole and an aldehyde with a catalytic amount of iodine, followed by an acid-catalyzed intramolecular cyclization with an ortho ester. The parent indolo[3,2-b]carbazoles (ICZs) could be converted to various functional derivatives. Both N-alkylation and N-arylation were successfully accomplished, and azo-coupling, formylation, as well as bromination were performed in a regioselective way leading to the formation of novel functional 6,12-disubstituted indolo[3,2-b]carbazoles. Starting from a monoformylated indolocarbazole, novel benzimidazolyl-substituted derivatives were synthesized, while Suzuki cross-couplings on a monobrominated building block afforded a novel pathway toward functionally arylated ICZs.
Method for sensitivity analysis of photonic crystal devices (2004)

We present a new method for sensitivity analysis of photonic crystal devices. The algorithm is based on a finite-difference frequency-domain model and uses the adjoint variable method and perturbation theory techniques. We show that our method is highly efficient and accurate and can be applied to calculation of the sensitivity of transmission parameters of resonant nanophotonic devices.