gebhart/patrepeval huggingface dataset:
Effect of annealing temperature on the texture of rolled tantalum and tantalum-10 wt % tungsten (1994)

The effect of annealing temperature on crystallographic texture was investigated on straight- and cross-rolled Ta and cross-rolled Ta-10wt %W sheets. Textures were measured on coupons cut from rolled sheets and annealed for one hour at 800 to 1550 C. In particular the effect of annealing temperature on volume fraction of grains having (II 1) and (100) crystal directions nearly aligned with the plate normal was investigated. In the pure tantalum sheets, increased annealing temperature lead to increased fractions of the (111) component. The same was true for the Ta-10wt %W but much higher temperatures were required to change the texture from a (100) type texture to a more (111) type texture. In addition, the influence of the annealing temperature on the sharpness of the texture; on the surface to centerline texture gradient; and on the in-plane symmetry of the texture was investigated.
Testosterone: The Crucial Hormone Responsible for Depressing Myocardial Function in Males After Trauma-Hemorrhage (1998)

Testosterone antagonism in males might be an effective approach for maintaining myocardial function after adverse circulatory conditions. Although testosterone depletion in male trauma victims is neither practical nor advocated, testosterone receptor blockade after trauma may represent a novel and useful adjunct for maintaining normal myocardial performance under those conditions.
Diseases of phenylalanine metabolism. (1979)

Continuing investigation of the system that hydroxylates phenylalanine to tyrosine has led to new insights into diseases associated with the malfunction of this system. Good evidence has confirmed that phenylketonuria (PKU) is not caused by a simple lack of phenylalanine hydroxylase. Dihydropteridine reductase deficiency as well as defects in biopterin metabolism may also cause the clinical features of phenylketonuria. Furthermore, these diseases do not respond to the standard treatment for phenylketonuria.
Brazilian Trees and their Adaptation in the Southern USA (1977)

Stein, J.D. 1976. Insects: a guide to their collection, identification, preservation, and shipment. USDA Forest Service Research Note RM-311, Rocky Mountain Forest and Range Experiment Station, Fort Collins, Colorado. Current urban forestry programs emphasize protection and management of planted trees. A survival survey in the Plains area indicated that 39 percent of all trees encountered were dead, with the majority mortality factor attributed to insects. Thus it is desirable to identify the insects responsible for damage, determine their biology, establish whether the insect is a new pest or a new outbreak of an old pest, and recommend control measures, if appropriate. A common question from property owners is, How do we get this information? This Note was compiled to inform the public about whom to contact for insect identification, and how to adequately collect, preserve, and ship specimens to the insect specialist.
Molecular Recognition of DNA by Hoechst Benzimidazoles: Exploring Beyond the Pyrrole-Imidazole-Hydroxypyrrole Polyamide-Pairing Code (2000)

A series of three-ring analogs of the minor-groove-binding molecule Hoechst 33258 (1), consisting of benzimidazole (B), imidazopyridine (P), and hydroxybenzimidazole (H) monomers, have been synthesized in order to investigate both their sequence specificity and binding modes. MPE⋅FeII Footprinting has revealed the preference of both PBB and BBB ligands for 5′-WGWWW-3′ and 5′-WCWWW-3′ tracts, as well as A⋅T-rich sequences. Affinity-cleavage titrations show no evidence for a 2 : 1 binding mode of these Hoechst analogs. Importantly, all derivatives are oriented in one direction at each of their binding sites. The implications of these results for the design of minor-groove-binding small molecules is discussed.
Active Immunization of Mice Against Candida albicans (1961)

Mice were vaccinated by repeated subcutaneous inoculations of living, merthiolate-killed, or sonically-ruptured cells of C. albicans and were then challenged intravenously with 104 or 105 viable particles of a homologous strain. Although not all of the vaccinated mice survived challenge, a significant degree of resistance was conferred since fewer deaths occurred among vaccinated animals.
A new family of mesoporous molecular sieves prepared with liquid crystal templates (1992)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTA new family of mesoporous molecular sieves prepared with liquid crystal templatesJ. S. Beck, J. C. Vartuli, W. J. Roth, M. E. Leonowicz, C. T. Kresge, K. D. Schmitt, C. T. W. Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, and J. L. SchlenkerCite this: J. Am. Chem. Soc. 1992, 114, 27, 10834–10843Publication Date (Print):December 1, 1992Publication History Published online1 December 1992Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ja00053a020https://doi.org/10.1021/ja00053a020research-articleACS PublicationsCopyright © 1992 American Chemical SocietyRequest reuse permissionsArticle Views42942Altmetric-Citations9716LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY: THE TEENAGE YEARS (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY: THE TEENAGE YEARSAlan G. Marshal and Peter B. GrosshansCite this: Anal. Chem. 1991, 63, 4, 215A–229APublication Date (Print):February 15, 1991Publication History Published online30 May 2012Published inissue 15 February 1991https://pubs.acs.org/doi/10.1021/ac00004a713https://doi.org/10.1021/ac00004a713research-articleACS PublicationsRequest reuse permissionsArticle Views360Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Establishment of Enzyme Immunoassay of Human Thrombomodulin in Plasma and Urine Using Monoclonal Antibodies (1990)

Thrombomodulin, TM, is an endothelial cell membrane protein acting as a cofactor for the activation of plasma protein C. Soluble TM is present in plasma and urine of normal subjects. Enzyme immunoassay, EIA, for human TM was developed using mouse monoclonal antibodies against human placental TM in this paper. We obtained four types of the monoclonal antibodies against human placental TM. EIA sandwich method using three types of the monoclonal antibodies enabled us to measure almost all of 6 and 7 TM subspecies in plasma and urine, respectively, except 1 subspecies, 31 kDa TM. There was no interference from other components of plasma and urine in the assay conditions. Titration curves of purified TM in buffer or in normal plasma were linear within the range from 0.08 to 10 ng/ml. The coefficient of variation at 0.08 ng/ml TM was 4.7%. TM titer with buffer, assayed by this method, was reduced by the addition of thrombin at the final concentration of 20 U/ml, but the titer with plasma was not reduced even at 100 U/ml. These concentrations of thrombin are far larger than those which would be formed in circulation. TM levels in plasma and urine of normal subjects collected in the morning were 35.2 +/- 8.32 ng/ml (n = 346) and 111 +/- 31.6 ng/ml (n = 33), respectively. TM level in plasma did not differ from the level in serum. Circadian fluctuation of plasma TM was not significant in 10 normal adults, although a tendency of increase in TM excretion to urine was found rather in the day time than the other times.(ABSTRACT TRUNCATED AT 250 WORDS)
Use of colony stimulating factors (G-CSF and GM-CSF) after allogeneic stem cell transplantation in adult patients: A meta-analysis of published studies (2004)

6638 Background: Use of colony stimulating factors (CSFs) accelerate the hematopoietic recovery after allogeneic stem cell transplant (allo-SCT). The impact of using CSFs after allo-SCT on survival and duration of hospitalization is unclear. The primary objectives of our meta-analysis were the effect of CSFs on 100-day survival, long-term survival, and duration of hospitalization. The secondary objectives were hematopoietic recovery, GVHD, febrile neutropenia, use of parenteral antibiotics, transplant related mortality, relapse rate, and DFS. Methods: Data search of published studies included Medline (1966–2003), Embase, Cochrane library and hand search of references. Studies were included if they were randomized or controlled trials of using CSFs after allo-SCT versus placebo or no treatment. A quality score was generated to assess the studies (7 points score based on predetermined quality items). All data extraction and quality assessment were done in duplicate independently. . Results: Eight randomized or controlled clinical trials were included (n = 458)(G-CSF = 4, GM-CSF = 4). The mean quality score was 4 / 7. Hematological malignancies were the underlying disease in most studies (one study included solid tumors). CSFs group and placebo / no treatment group were balanced in age, sex, disease status, conditioning regimens, number of stem cell infused, and GVHD prophylaxis. There was no difference on 100-day mortality between the CSFs group and the placebo / no treatment group (odds ratio 1.21 [95% CI 0.76, 1.92]; P value = 0.41). The long term mortality was also not different (odds ratio 0.79 [95% CI 0.54, 1.16]; P value = 0.23). Results on duration of hospitalization, the other secondary endpoints, and an economic analysis will be presented. Conclusions: CSFs improve hematopoietic recovery when used after allo-SCT. There is no evidence CSFs have impact on 100-day survival or long-term survival. Larger sample size and better quality studies are needed to address this question. Economic analysis will be presented. We are conducting a similar meta-analysis addressing the role of CSFs in autologous SCT. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen Amgen
Adaptive transmitting antenna arrays with feedback (1994)

We address the problem of transmitting multiple cochannel signals from an antenna array to several receivers so that each receiver gets its intended signal with minimum crosstalk from the remaining signals. In addition to the usual "information" mode, we propose a "probing" mode during which probing signals received at the mobiles are fed back to the transmitter. These probing signals are used to identify an unknown propagation environment, enabling the transmitter to form the necessary transmission beampatterns.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages (2005)

Macrophages are central to host defense against microbes, but intracellular pathogens have evolved to evade their antimicrobial functions. Mycobacterium tuberculosis (MTB) has successfully exploited macrophages as its primary niche in vivo, but the bacterial genome-wide requirements that promote its intracellular survival remain undefined. Here we comprehensively identify the MTB genes required for survival by screening for transposon mutants that fail to grow within primary macrophages. We identify mutants showing decreased growth in macrophage environments that model stages of the host immune response. By systematically analyzing several biologically relevant data sets, we have been able to identify putative pathways that could not be predicted by genome organization alone. In one example, phosphate transport, requiring physically unlinked genes, was found to be critical for MTB growth in macrophages and important for establishing persistent infection in lungs. Remarkably, the majority of MTB genes found by this analysis to be required for survival are constitutively expressed rather than regulated by macrophages, revealing the host-adapted lifestyle of an evolutionarily selected intracellular pathogen.
Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide (2010)

Dialkylbiaryl phosphines are a valuable class of ligand for Pd-catalyzed amination reactions and have been applied in a range of contexts. This review attempts to aid the reader in the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations.
Light trails: a sub-wavelength solution for optical networking (2004)

All-optical networks are able to transport data from source to destination entirely in the optical domain. This is a departure from current optical networks that rely on optical-electrical-optical (OEO) conversion at each intermediate connection node to route data properly. The opacity inherent in traditional networks is costly in terms of limiting bandwidth and increasing switching complexity. MPLS, OBS and OPS have been proposed as solutions for realizing an all-optical network. MPLS and OBS have the advantages of creating all-optical connections between nodes, but do not allow intermediate nodes to use the wavelength as well. Additionally, optical switches are constantly being reconfigured to accommodate new connections. OPS can make switching decisions in the optical domain, but the technology is immature. Light trail technology tries to avoid the pitfalls of immature technology, the inability of intermediate nodes to use a connection wavelength, and the constant reconfiguration of switches. A light trail is a unidirectional optical bus between nodes that allows intermediate nodes to access the bus. The goal is to minimize the amount of active switching that needs to be done by allowing intermediate nodes to use a connection that has already been setup. Connections are not constantly being setup and torn down, but rather exist for as long as they are being used by any of the nodes along their light trail.
Purification and characterization of the lipoprotein-associated coagulation inhibitor from human plasma (1989)

The lipoprotein-associated coagulation inhibitor (LACI) has been isolated from human plasma using a combination of hydrophobic, ion-exchange, and affinity chromatography. The final purification required was greater than 500,000-fold with a yield of 13%. Plasma LACI, on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, contains major bands at 40 and 46 kDa and minor bands at 55, 65, 75, 90, and approximately 130 kDa. All of the molecular weight forms are recognized by antibodies to LACI's amino and carboxyl termini and are able to inhibit the factor VII(a)-tissue factor complex and factor Xa. Plasma LACI, reduced with beta-mercaptoethanol, migrates on sodium dodecyl-sulfate-polyacrylamide gel electrophoresis as a doublet at 42 kDa and has an amino-terminal sequence essentially identical to that of HepG2 LACI. The difference in size between reduced plasma LACI (42 kDa) and HepG2 LACI (47 kDa) may be related to differing degrees of N-linked glycosylation. The 46-kDa and larger forms of unreduced plasma LACI are associated with apolipoprotein A-II (apoA-II) in mixed disulfide linkages. Studies using isolated lipoproteins show that low density lipoprotein (LDL) contains primarily the 40-kDa form of LACI, whereas high density lipoprotein (HDL) contains primarily the 46-kDa form of LACI (LACI/apoA-II complexes). Gel filtration of a fresh plasma sample showed approximately 50% of plasma LACI to be associated with LDL/very low density lipoprotein, 44% with HDL, and the remaining 6% to not be associated with lipoproteins.
Neurotropism of Highly Pathogenic Avian Influenza Virus A/Chicken/Indonesia/2003 (H5N1) in Experimentally Infected Pigeons (Columbia livia f. domestica) (2006)

This investigation assessed the susceptibility of experimentally infected pigeons to the highly pathogenic avian influenza virus (HPAIV) H5N1 that caused recent outbreaks of avian influenza in birds and humans in several countries of Asia. For this purpose 14 pigeons were infected ocularly and nasally with 10(8) EID50 and clinical signs were recorded and compared with five chickens infected simultaneously as positive controls. The chickens demonstrated anorexia, depression, and 100% mortality within 2 days postinoculation. Three of the pigeons died after a history of depression and severe neurological signs consisting of paresis to paralysis, mild enteric hemorrhage, resulting in a mortality of 21%. Gross lesions in these pigeons were mild and inconsistent. Occasionally subcutaneous hyperemia and hemorrhage and cerebral malacia were observed. Microscopic lesions and detection of viral antigen were confined to the central nervous system of these pigeons. In the cerebrum and to a minor extent in the brain stem a lymphohistiocytic meningoencephalitis with disseminated neuronal and glial cell necrosis, perivascular cuffing, glial nodules, and in one bird focally extensive liquefactive necrosis could be observed. The remaining nine pigeons showed neither clinical signs nor gross or histological lesions associated with avian influenza, although seroconversion against H5 indicated that they had been infected. These results confirm that pigeons are susceptible to HPAIV A/chicken/Indonesia/2003 (H5N1) and that the disease is associated with the neurotropism of this virus. Although sentinel chickens and most pigeons did not develop disease, further experiments have to elucidate whether or not Columbiformes are involved in transmission and spread of highly pathogenic avian influenza.
Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes (2008)

TNFRSF13B encodes transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), a B cell- specific tumor necrosis factor (TNF) receptor superfamily member. Both biallelic and monoallelic TNFRSF13B mutations were identified in patients with common variable immunodeficiency disorders. The genetic complexity and variable clinical presentation of TACI deficiency prompted us to evaluate the genetic, immunologic, and clinical condition in 50 individuals with TNFRSF13B alterations, following screening of 564 unrelated patients with hypogammaglobulinemia. We identified 13 new sequence variants. The most frequent TNFRSF13B variants (C104R and A181E; n=39; 6.9%) were also present in a heterozygous state in 2% of 675 controls. All patients with biallelic mutations had hypogammaglobulinemia and nearly all showed impaired binding to a proliferation-inducing ligand (APRIL). However, the majority (n=41; 82%) of the pa-tients carried monoallelic changes in TNFRSF13B. Presence of a heterozygous mutation was associated with antibody deficiency (P< .001, relative risk 3.6). Heterozygosity for the most common mutation, C104R, was associated with disease (P< .001, relative risk 4.2). Furthermore, heterozygosity for C104R was associated with low numbers of IgD(-)CD27(+) B cells (P= .019), benign lymphoproliferation (P< .001), and autoimmune complications (P= .001). These associations indicate that C104R heterozygosity increases the risk for common variable immunodeficiency disorders and influences clinical presentation.
Intracellularly Expressed Single-Domain Antibody against p15 Matrix Protein Prevents the Production of Porcine Retroviruses (2003)

The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.
Combining Effective Strains of Trichoderma harzianum and Solid Matrix Priming to Improve Biological Seed Treatments (1989)

In all crop-pathogen combinations, Trichoderma strains increased stands relative to the untreated control and were as effective as the chemical fungicides, even in the absence of solid matrix priming. Priming of seeds treated with Trichoderma strains increased plant stands in solid infested with F. graminearum and P. ultimum but not in soils infested with R. solani or S. rolfsii. In soils infested with P. ultimum, strain T95 generally gave the poorest results, T12 was intermediate, and the progeny strains (22 and 106) gave improved stands
A Comparison of CMAC Neural Network and Traditional Adaptive Control Systems (1989)

A neural network based controller similar to Miller's CMAC method [6] is compared to a self-tuning regulator [2] and a Liapunov based model reference controller [8]. The three control algorithms are tested on exactly the same control problems. Results are obtained for the case where the system being controlled is linear and noise free, for the case where noise is added to the measurements, and for the case where a non-linear system is controlled. Comparisons made with respect to closed-loop system stability, speed of adaptation, noise rejection, robustness, the number of required calculations and system tracking performance indicate that the neural network approach exhibits the potential to solve some of the problems that have plagued more traditional adaptive control systems.
Secure Continuous Biometric-Enhanced Authentication (2000)

Abstract : Biometrics have the potential to solidify person authentication by examining unforgeable features of individuals. This paper explores issues involved with effective integration of biometric-enhanced authentication into computer systems and design options for addressing them. Because biometrics are not secrets, systems must not use them like passwords; otherwise, biometric-based authentication will reduce security rather than increase it. A novel biometric-enhanced authentication system, based on a trusted camera that continuously uses face recognition to verify identity, is described and evaluated in the context of Linux. With cryptographically-signed messages and continuous authentication, the difficulty of bypassing desktop authentication can be significantly increased.