gebhart/patrepeval huggingface dataset:
Sensing from the basement (2006)

The home deployment of sensor-based systems offers many opportunities, particularly in the area of using sensor-based systems to support aging in place by monitoring an elder's activities of daily living. But existing approaches to home activity recognition are typically expensive, difficult to install, or intrude into the living space. This paper considers the feasibility of a new approach that "reaches into the home" via the existing infrastructure. Specifically, we deploy a small number of low-cost sensors at critical locations in a home's water distribution infrastructure. Based on water usage patterns, we can then infer activities in the home. To examine the feasibility of this approach, we deployed real sensors into a real home for six weeks. Among other findings, we show that a model built on microphone-based sensors that are placed away from systematic noise sources can identify 100% of clothes washer usage, 95% of dishwasher usage, 94% of showers, 88% of toilet flushes, 73% of bathroom sink activity lasting ten seconds or longer, and 81% of kitchen sink activity lasting ten seconds or longer. While there are clear limits to what activities can be detected when analyzing water usage, our new approach represents a sweet spot in the tradeoff between what information is collected at what cost.
Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites (1991)

By examining a large database of amino acid sequences of antibodies of various specificities, we have found that many antibodies of distinctly different specificities assemble identical VL domains with different VH domains. In contrast, rarely is the same VH domain found in sets of antibodies of different specificities. We identified additional sets of antibodies of different specificities and identical sequences covering amino acid residues VH 1 to 94 and VL 1 to 95. In addition, there were segments of additional antibodies for which complete sequences were not available, but identities were seen in VL CDR1, VL CDR2, and VL CDR3 up to the VL-JL junction. The finding that there are many identical VL 1 to 95 segments with different VH 1 to 94 sequences, and vice versa, raises important questions as to the role of VH in influencing the conformation of VL and, conversely, the role of VL in influencing the conformation of VH. Evidence is also cited indicating that a single amino acid change may seriously disrupt site structure and in some instances abolish binding. Our findings suggest that it will be important in the future to investigate further conformational effects on antibody structure by using X-ray crystallography, nuclear magnetic resonance spectroscopy, or other methods, to obtain a better understanding of the functions and topography of antibody-combining sites.
The solid solution BaLi1–xCuxPO4(x⩽ 0.5): an example of Cu+single-ion luminescence in oxide insulators (1996)

The crystallographic and spectroscopic properties of the solid solution BaLi1–xCuxPO4(0 ⩽x⩽ 0.5) have been investigated as a function of temperature and monovalent copper concentration. A structural description of the compounds is proposed, on the basis of an isotypy with the hexagonal form of β-SiO2 trydimite. This description involves the existence of a 1:1 ordering between the cross-linked LiO4 and PO4 tetrahedra, in a way such that the replacement of lithium by copper cannot involve any direct Cu+–Cu+ interaction in the network. This argument is supported by the spectroscopic results. The materials exhibit a unique blue emission under UV excitation, whatever the temperature and the composition. This luminescence possesses a time-constant which is independent of the copper concentration. It is attributed unambiguously to Cu+ single ions.
An AA-Sized Vibration-Based Microgenerator for Wireless Sensors (2007)

This paper deals with the vibration-to-electrical transducer that has an M-size form factor and generates a DC voltage that can power off-the-shelf integrated circuits. Vibration-powered wireless sensors obtain power from machine vibrations, human movement, or other forms of motion. The feasibility of incorporating micro power transducers (MPTs) with a voltage multiplier and rectifier to make a micro power generator (MPG) is demonstrated, that has the same size and shape as an AA battery. The AA-sized module includes a voltage multiplier and a large capacitor to produce the DC output
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression (2009)

Our data provide evidence for the molecular and cellular mechanisms that support the rationale for the clinical implementation of antibrain cancer immunotherapies in combination with tumor killing approaches in order to elicit effective antitumor immune responses, and thus, will impact clinical neuro-oncology practice.
Magnetic Resonance Microscopy of Embryonic Cell Lineages and Movements (1994)

Key events in vertebrate embryogenesis are difficult to observe in many species. High-resolution magnetic resonance imaging was used to follow cell movements and lineages in developing frog embryos. A single cell was injected at the 16-cell stage with a contrast agent, based on the gadolinium chelate gadolinium-diethylenetriamine pentaacetic acid-dextran. The labeled progeny cells could be followed uniquely in three-dimensional magnetic resonance images, acquired from the embryo over several days. The results show that external ectodermal and internal mesodermal tissues extend at different rates during amphibian gastrulation and neurulation.
Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin (2009)

Acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. Propionibacterium acnes (P. acnes), a gram-positive anareobic bacterium, plays a critical role in the development of these inflammatory lesions. This study aimed at determining whether reactive oxygen species (ROS) are produced by keratinocytes upon P. acnes infection, dissecting the mechanism of this production, and investigating how this phenomenon integrates in the general inflammatory response induced by P. acnes. In our hands, ROS, and especially superoxide anions (O2(*-)), were rapidly produced by keratinocytes upon stimulation by P. acnes surface proteins. In P. acnes-stimulated keratinocytes, O2(*-) was produced by NAD(P)H oxidase through activation of the scavenger receptor CD36. O2(*-) was dismuted by superoxide dismutase to form hydrogen peroxide which was further detoxified into water by the GSH/GPx system. In addition, P. acnes-induced O2(*-) abrogated P. acnes growth and was involved in keratinocyte lysis through the combination of O2(*-) with nitric oxide to form peroxynitrites. Finally, retinoic acid derivates, the most efficient anti-acneic drugs, prevent O2(*-) production, IL-8 release and keratinocyte apoptosis, suggesting the relevance of this pathway in humans.
Trastuzumab in the management of early and advanced stage breast cancer. (2007)

Trastuzumab is a monoclonal humanized antibody that has revolutionized the treatment of patients with Her2-positive breast cancer. Already well established in advanced stage disease, the substance was recently introduced in the adjuvant setting, reducing disease recurrences by more than 50% and mortality by approximately one third. Trastuzumab is a rationally designed substance which binds to cancer cells expressing the targeted antigen, and, by different mechanisms, causes tumor cell degradation. However, only one third of patients have an initial response to trastuzumab therapy, and the majority of initial responders demonstrate disease progression within 1 year of treatment initiation. It is therefore necessary to gain further insight into mechanisms of resistance, and develop ways to overcome those. In this article, the role of trastuzumab in early and advanced stage breast cancer is reviewed. We discuss current understandings of the specific tumor biology of Her2-positive breast cancer, and review the mechanism of action of trastuzumab. Further, we try to highlight possible mechanisms of resistance.
A feasibility study of magnetic resonance driven electrical impedance tomography using a phantom (2013)

Imaging the electrical properties of human tissue may aid in cancer diagnoses or monitoring organ function. Traditionally, the electrical properties are revealed with electrical impedance tomography, where currents are injected into human tissue and voltages are measured on the surface. This paper focuses on a method of measuring the electrical properties using a magnetic resonance (MR) scanner without current injection. In magnetic resonance driven electrical impedance tomography (MRDEIT), the MR phenomenon is used to induce currents in the body and the complex permittivity map is inversely computed from the difference between the modeled electric field and the actual surface electrode measurements. Computer simulations indicate that with noise level under 20%, the contrast is visually discernible in the reconstruction image. A phantom experiment is demonstrated and this supports results from computer simulation studies. The noise level in electrode measurements is evaluated to be approximately 7.8% from repeated experiments, confirming the potential to reconstruct conductivity contrast using MRDEIT. With further improvements in hardware and image reconstruction, MRDEIT may provide an additional contrast mechanism reflecting the electrical properties of human tissue, which may ultimately be used to diagnose a cancer or assist in electroencephalography.
Effects of Low-Dose EPA-E on Glycemic Control, Lipid Profile, Lipoprotein(a), Platelet Aggregation, Viscosity, and Platelet and Vessel Wall Interaction in NIDDM (1993)

Purified EPA-E in doses of 900 and 1800 mg reduces Platelet-activating factor-induced platelet aggregation without negatively affecting glycemic control. Low-density-lipoprotein cholesterol was elevated in the 1800-mg group.
The expression and significance of Fas receptor and Fas ligand in gastric carcinoma SGC-7901 cell line (2000)

By using immunohistochemical SABC method, the expression of fas receptor and fas ligand in gastric carcinoma cell line was observed so as to apply morphological evidences for the founctions of fas receptor and fasl. It was shown that all of the gastric cancinoma SGC-7901 cells, either fas receptor or fasl, were positive. The positive subnstances were distributed in the cytoplasm while the nuclei of the cells were negitive for them. The results indicated that fas gene might be involved in the regulation of the growth of the gastric carcinoma cells.
Managerial Decision Analysis (1989)

Introduction to Decision Modeling. The Decision Analysis Approach Case Studies: Exo Health Universal Airlines. Decision Model Structuring Case Studies: Atlanta Photo Finishers (A) Superior Power and Gas Company (A). Probability Assessment. Appendix A: A Probability Primer. Choosing between Alternatives Case Study: James Johnson Art Auctions (A). The Expected Utility Decision Criterion Case Study: James Johnson Art Auctions (B). Appendix B: The Axioms of Decision Analysis/Expected Utility. Multiattributed Utility Functions. Sensitivity Analysis Case Study: Digmout Mines Inc. (A). Simulation in Decision Analysis Case Studies: RW Industries Northern Insurance Brokers. Revision of Probabilities Case Studies: Printem Inc. Bangpay Insurance Company. The Value of Information Case Studies: Sunbelt Software Services (A) Sunbelt Software Services (B). Implementation of Decision Analysis Case Study: Mirassou Vineyards (A). Behavioral Aspects of Decision Analysis. Decision Support Systems. Complementary Decision Analysis Aids Appendix: Arborist Documentation. 700 pp., 1988, hardbound, ISBN 0-256-06162-9.
Precise Temporal Modulation in the Response of the SOS DNA Repair Network in Individual Bacteria (2005)

The SOS genetic network is responsible for the repair/bypass of DNA damage in bacterial cells. While the initial stages of the response have been well characterized, less is known about the dynamics of the response after induction and its shutoff. To address this, we followed the response of the SOS network in living individual Escherichia coli cells. The promoter activity (PA) of SOS genes was monitored using fluorescent protein-promoter fusions, with high temporal resolution, after ultraviolet irradiation activation. We find a temporal pattern of discrete activity peaks masked in studies of cell populations. The number of peaks increases, while their amplitude reaches saturation, as the damage level is increased. Peak timing is highly precise from cell to cell and is independent of the stage in the cell cycle at the time of damage. Evidence is presented for the involvement of the umuDC operon in maintaining the pattern of PA and its temporal precision, providing further evidence for the role UmuD cleavage plays in effecting a timed pause during the SOS response, as previously proposed. The modulations in PA we observe share many features in common with the oscillatory behavior recently observed in a mammalian DNA damage response. Our results, which reveal a hitherto unknown modulation of the SOS response, underscore the importance of carrying out dynamic measurements at the level of individual living cells in order to unravel how a natural genetic network operates at the systems level.
Rationalizing and Controlling the Surface Structure and Electronic Passivation of Cesium Lead Halide Nanocrystals (2018)

Colloidal lead halide perovskite nanocrystals (NCs) have recently emerged as versatile photonic sources. Their processing and luminescent properties are challenged by the lability of their surfaces, i.e., the interface of the NC core and the ligand shell. On the example of CsPbBr<sub>3</sub> NCs, we model the nanocrystal surface structure and its effect on the emergence of trap states using density functional theory. We rationalize the typical observation of a degraded luminescence upon aging or the luminescence recovery upon postsynthesis surface treatments. The conclusions are corroborated by the elemental analysis. We then propose a strategy for healing the surface trap states and for improving the colloidal stability by the combined treatment with didodecyldimethylammonium bromide and lead bromide and validate this approach experimentally. This simple procedure results in robust colloids, which are highly pure and exhibit high photoluminescence quantum yields of up to 95-98%, retained even after three to four rounds of washing.
A self-powered bidirectional DC solid state circuit breaker using two normally-on SiC JFETs (2015)

This paper reports self-powered, autonomously operated bidirectional solid state circuit breakers (SSCB) with two back-to-back connected normally-on SiC JFETs as the main static switch for DC power systems. The SSCBs detect short circuit faults by sensing the sudden voltage rise between its two power terminals in either direction, and draws power from the fault condition itself to turn and hold off the SiC JFETs. The two-terminal SSCB can be directly placed in a circuit branch without requiring any external power supply or extra wiring. A low-power, fast-starting, isolated DC/DC converter is designed and optimized to activate the SSCB in response to a short circuit fault. The SSCB prototypes are experimentally demonstrated to interrupt fault currents up to 150 amperes at a DC bus voltage of 400 volts within 0.7 microseconds.
Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer (2009)

Peripheral neurotoxicity is the major limiting factor for oxaliplatin therapy. Goshajinkigan (GJG), a traditional Japanese herbal medicine, was recently shown to be effective in protecting against the neurotoxicity of taxanes in Japan. We retrospectively investigated the effect of GJG on peripheral neurotoxicity associated with oxaliplatin therapy. Ninety patients with metastatic colorectal cancer that received FOLFOX4 or modified FOLFOX6 therapy were assigned to receive one of the following adjuncts: oral GJG at 7.5 g day(-1) (Group A, n = 11), intravenous supplementation of calcium gluconate and magnesium sulfate (1 g each before and after FOLFOX) (Group B, n = 14), combined GJG and calcium gluconate and magnesium sulfate therapies (Group C, n = 21), or no concomitant therapy (Group D, n = 44). The incidence of peripheral neurotoxicity was investigated when the cumulative dose of oxaliplatin exceeded 500 mg m(-2). When the cumulative dose of oxaliplatin exceeded 500 mg m(-2), the incidence of neuropathy (all grades) in Groups A-D was 50.0%, 100%, 78.9%, and 91.7%, respectively. It was lowest in the group that received GJG alone. Concomitant administration of GJG reduced the neurotoxicity of oxaliplatin in patients that received chemotherapy for colorectal cancer.
Bacterial Manganese Reduction and Growth with Manganese Oxide as the Sole Electron Acceptor (1988)

Microbes that couple growth to the reduction of manganese could play an important role in the biogeochemistry of certain anaerobic environments. Such a bacterium, Alteromonas putrefaciens MR-1, couples its growth to the reduction of manganese oxides only under anaerobic conditions. The characteristics of this reduction are consistent with a biological, and not an indirect chemical, reduction of manganese, which suggest that this bacterium uses manganic oxide as a terminal electron acceptor. It can also utilize a large number of other compounds as terminal electron acceptors; this versatility could provide a distinct advantage in environments where electron-acceptor concentrations may vary.
Tyrosine kinase inhibition increases functional parkin‐ B eclin‐1 interaction and enhances amyloid clearance and cognitive performance (2013)

Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β-amyloid (plaques) and hyper-phosphorylated Tau (tangles). Here we show that AD animals have high levels of insoluble parkin and decreased parkin-Beclin-1 interaction, while peripheral administration of TKIs, including Nilotinib and Bosutinib, increases soluble parkin leading to amyloid clearance and cognitive improvement. Blocking Beclin-1 expression with shRNA or parkin deletion prevents tyrosine kinase (TK) inhibition-induced amyloid clearance, suggesting that functional parkin-Beclin-1 interaction mediates amyloid degradation. Isolation of autophagic vacuoles (AVs) in AD mouse brain shows accumulation of parkin and amyloid, consistent with previous results in AD brains, while Bosutinib and Nilotinib increase parkin-Beclin-1 interaction and result in protein deposition in the lysosome. These data suggest that decreased parkin solubility impedes parkin-Beclin-1 interaction and amyloid clearance. We identified two FDA-approved anti-cancer drugs as potential treatment for AD.
DIRECT DESIGN OF PARALLEL SECOND-ORDER FILTERS FOR INSTRUMENT BODY MODELING (2007)

This paper 1 presents a direct design technique for parallel second-order sections based on a perceptually motivated logarithmic scale, with application to instrument body modeling. Traditional FIR and IIR design techniques work on a linear frequency scale, which is usually not optimal for audio applications. Warped filters and Kautz filters are good candidates for perceptually motivated filter design. However, the direct implementation of warped or Kautz filters is computationally less efficient compared to an IIR filter of the same order. The perceptually motivated frequency resolution can also be achieved by the proposed design method, without the disadvantage of increased computational complexity. The filter design has two phases. First, the pole frequencies of the second-order sections are set to a predefined logarithmic scale, or can be determined from a warped filter design. Then the zeros are found by a simple least squares algorithm, as the optimization problem becomes linear in parameters for a given set of poles. As high-order (up to 1000) filters can be robustly designed, this technique is particularly well suited for instrument body modeling. Moreover, the parallel structure allows flexible modifications to the body transfer function. 1.
On-Chip Native Gel Electrophoresis-Based Immunoassays for Tetanus Antibody and Toxin (2004)

By integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device, we have developed a microanalytical platform for performing electrophoresis-based immunoassays. The microfluidic immunoassays are performed by gel electrophoretic separation and quantitation of bound and unbound antibody or antigen. To retain biological activity of proteins and maintain intact immune complexes, nondenaturing polyacrylamide gel electrophoresis conditions were investigated. Both direct (noncompetitive) and competitive immunoassay formats are demonstrated in microchips. A direct immunoassay was developed for detection of tetanus antibodies in buffer as well as diluted serum samples. After an off-chip incubation step, the immunoassay was completed in less than 3 min and the sigmoidal dose-response curve spanned an antibody concentration range from 0.17 to 260 nM. The minimum detectable antibody concentration was 0.68 nM. A competitive immunoassay was also developed for tetanus toxin C-fragment by allowing unlabeled and fluorescently labeled tetanus toxin C-fragment compete to bind to a limited fixed concentration of tetanus antibody. The immunoassay technique described in this work shows promise as a component of an integrated microfluidic device amenable to automation and relevant to development of clinical diagnostic devices.
Mechanisms of Endocytosis (2009)

Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-mediated endocytic mechanisms and dissect endocytic pathways that proceed independently of clathrin. These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis. We also critically review the role of caveolae and caveolin1 in endocytosis. We highlight the roles of lipids, membrane curvature-modulating proteins, small G proteins, actin, and dynamin in endocytic pathways. We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes.
Pyridazine Derivatives and Related Compounds Part 5. Pyrazolo[3,4-c]pyridazine: Synthesis and Some Reactions (1991)

This paper descri.bes the synthesis of three pyrimida[lr ,2' : 1 , 5 ]pyrazolo[3,4-&yfidazin (6,7 and 9) starting from 3-amino[3,4-clpyridazine (1).~yrimidoL5' ,4' :8,6]pyrimido[l' ,2' :1,5]pyrazolo[3,4-clpyridazine derivative (8) was obtained by condensing 7a with formamide.Reactions of 1 with acetic anhydride,~benzoyl chloride, phenacyl bromide and 4-chlorophenacyl bromide gave 3-substituted amino derivatives.
Tear Film Stability Analysis System (2004)

TSAS is a noninvasive and objective method with higher sensitivity for tear film stability analysis than SLE-BUT.
Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning (1998)

All the patient groups had greater airway wall thickening than the normal subjects as assessed by HRCT scanning, but patients with more severe asthma had greater airway wall thickening than those with mild asthma. The methodology described in this study may be useful in assessing airway calibre in early intervention studies with anti-inflammatory therapy.