gebhart/patrepeval huggingface dataset:
CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia (2015)

The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. Previous studies demonstrated that concentrations of CCL11 are elevated in the sera and cerebrospinal fluids (CSF) of patients with neuroinflammatory disorders, including multiple sclerosis. Moreover, the levels of CCL11 in plasma and CSF increase with age, and CCL11 suppresses adult neurogenesis in the central nervous system (CNS), resulting in memory impairment. However, the precise source and function of CCL11 in the CNS are not fully understood. In this study, we found that activated astrocytes release CCL11, whereas microglia predominantly express the CCL11 receptor. CCL11 significantly promoted the migration of microglia, and induced microglial production of reactive oxygen species by upregulating nicotinamide adenine dinucleotide phosphate-oxidase 1 (NOX1), thereby promoting excitotoxic neuronal death. These effects were reversed by inhibition of NOX1. Our findings suggest that CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders.
Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin (1996)

Glutamate-gated chloride channels, members of the ligand-gated ion channel superfamily, have been shown in nematodes and in insects to be a target of the antiparasitic agent avermectin. Two subunits of the Caenorhabditis elegans glutamate-gated chloride channel have been cloned: GluCl-alpha and GluCl-beta. We report the cloning of a Drosophila melanogaster glutamate-gated chloride channel, DrosGluCl-alpha, which shares 48% amino acid and 60% nucleotide identity with the C. elegans GluCl channels. Expression of DrosGluCl-alpha in Xenopus oocytes produces a homomeric chloride channel that is gated by both glutamate and avermectin. The DrosGluCl-alpha channel has several unique characteristics not observed in C. elegans GluCl: dual gating by avermectin and glutamate, a rapidly desensitizing glutamate response, and a lack of potentiation of the glutamate response by avermectin. The pharmacological data support the hypothesis that the DrosGluCl-alpha channel represents the arthropod H-receptor and an important target for the avermectin class of insecticides.
Inkjet Printing of Polymers: State of the Art and Future Developments (2004)

Abstract Inkjet printing is considered to be a key technology in the field of defined polymer deposition. This article provides an introduction to inkjet printing technology and a short overview of the available instrumentation. Examples of polymer inkjet printing are given, including the manufacturing of multicolor polymer light‐emitting diode displays, polymer electronics, three‐dimensional printing, and oral dosage forms for controlled drug release. Special emphasis is placed upon the utilized polymers and conditions, such as polymer structure, molar mass, solvents, and concentration. Studies on viscoelastic fluid jets and the formation of viscoelastic droplets under gravity indicate that strain hardening is the key parameter that determines the inkjet printability of polymer solutions.
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice (2008)

Adiponectin is an adipocyte-derived collectin that acts on a wide range of tissues including liver, brain, heart, and vascular endothelium. To date, little is known about the actions of adiponectin in the lung. Herein, we demonstrate that adiponectin is present in lung lining fluid and that adiponectin deficiency leads to increases in proinflammatory mediators and an emphysema-like phenotype in the mouse lung. Alveolar macrophages from adiponectin-deficient mice spontaneously display increased production of tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase (MMP-12) activity. Consistent with these observations, we found that pretreatment of alveolar macrophages with adiponectin leads to TNF-alpha and MMP-12 suppression. Together, our findings show that adiponectin leads to macrophage suppression in the lung and suggest that adiponectin-deficient states may contribute to the pathogenesis of inflammatory lung conditions such as emphysema.
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase. (1994)

5-Hydroxy-2'-deoxycytidine (5-OHdC) and 5-hydroxy-2'-deoxyuridine (5-OHdU) are major products of oxidative DNA damage with mutagenic potential. Until now, no enzymatic activity responsible for their removal has been identified. We report here that both 5-OHdC and 5-OHdU are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase (FPG). 5-OHdU is also a substrate for uracil DNA N-glycosylase. Consistent with their mechanisms of action on previously described substrates, endonuclease III removes 5-OHdC and 5-OHdU via a N-glycosylase/beta-elimination reaction, FPG follows a N-glycosylase/beta,delta-elimination reaction, and uracil N-glycosylase removes 5-OHdU by N-glycosylase action leaving behind an abasic site. Endonuclease III removes both lesions more efficiently than FPG, and both endonuclease III and FPG remove 5-OHdC slightly more efficiently than 5-OHdU. Uracil DNA N-glycosylase removes 5-OHdU more efficiently than the other two enzymes and has no activity on 5-OHdC even when present in great excess. Analysis of crude extracts obtained from wild type and endonuclease III deletion mutants of E. coli correlated well with data obtained with the purified enzymes.
A silicon nanocrystals based memory (1996)

A new memory structure using threshold shifting from charge stored in nanocrystals of silicon (≊5nm in size) is described. The devices utilize direct tunneling and storage of electrons in the nanocrystals. The limited size and capacitance of the nanocrystals limit the numbers of stored electrons. Coulomb blockade effects may be important in these structures but are not necessary for their operation. The threshold shifts of 0.2–0.4 V with read and write times less than 100’s of a nanosecond at operating voltages below 2.5 V have been obtained experimentally. The retention times are measured in days and weeks, and the structures have been operated in an excess of 109 cycles without degradation in performance. This nanomemory exhibits characteristics necessary for high density and low power.
The allergen challenge chamber: a valuable tool for optimizing the clinical development of pollen immunotherapy (2010)

The clinical development of allergen immunotherapy for allergic rhinoconjunctivitis because of pollen is complicated by seasonal, geographical and subject-related variability in allergen exposure. Using an allergen challenge chamber (ACC), a room that enables reproducible challenges with controlled levels of inhalant allergens for several hours, these factors can be controlled. The ACC has often been used to evaluate symptomatic medications but is underexploited in the field of allergen immunotherapy. When used in conjunction with a programme of natural-exposure trials, the ACC enables researchers to (i) facilitate the allergen immunotherapy dose-finding process, (ii) accelerate the transition from Phase I/II to Phase III trials, (iii) characterize the onset and maintenance of action, (iv) avoid the confounding effects of rescue medication, (v) better characterize the baseline or pretreatment characteristics of trial subjects, (vi) perform better-standardized physical and laboratory measurements during an acute challenge, (vii) simplify trial logistics and use smaller numbers of subjects than would be required in equivalent natural-exposure studies and (viii) support (but not replace) Phase III natural-exposure trials for the investigation into long-term and disease-modifying effects. ACC studies can further increase levels of evidence for allergen immunotherapy--the only current therapy potentially capable of modifying the underlying allergic disease.
Characterization of a carcinogen‐induced murine B lymphocyte cell line of C3H/eB origin (1977)

A carcinogen-induced lymphoid tumor, denoted 38C-13, obtained in a T cell-depleted mouse of C3H/eB strain, was adapted to continuous culture in vitro and characterized with respect to its cell surface components. The cells possess IgM class immunoglobulins on their surface but do not secrete it. This membrane IgM is composed of mu and L-chains that are similar in apparent molecular weight to those of an IgM myeloma protein. It is also homogeneous as revealed by isoelectric focusing. The cells possess Fc receptors but lack complement receptors as well as Thy-1 and Ia alloantigens. These characteristics indicate that 38C-13 cells are transformed counterparts of small B lymphocytes at an early stage of differentiation.
What is coordination theory and how can it help design cooperative work systems? (1990)

"Appears in Proceedings of the Conference on Computer Supported Cooperative Work, Los Angeles, California, October, 1990."
Enhancing the electro-optical properties of liquid crystal nanodroplets for switchable Bragg gratings (2008)

Electrically switchable Bragg reflection gratings, comprised of periodic monolayers of liquid crystal nanodroplets embedded in a polymer, have historically displayed limited diffraction efficiency (< 90%). Attempts to increase diffraction efficiency by increasing the liquid crystal concentration lead to undesirable levels of incoherent scattering. We have developed a model of liquid crystal Bragg gratings to study and predict these properties for reflection filters. Examining the effective medium theory of inhomogeneous nanodroplet layers, we have investigated the enhancement of properties that lead to higher diffraction efficiency without increasing incoherent scattering. In particular, we focus on properties of nanodroplet ensembles that contribute to the permittivity modulation of the grating, leading to coherent diffraction, and permittivity variance, leading to incoherent scattering. Using the liquid crystal BL037 in a commercially available polymer as an example, we illustrate how a diffraction efficiency of 99% can be achieved, without simultaneously increasing the level of incoherent scattering, and compare this to the previous state of the art with these materials. We then demonstrate this approach experimentally, confirming the viability of the technique and the predictions of the model.
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl‐2 (2007)

Apoptosis of virally infected cells is an innate host mechanism used to prevent viral spread. However, viruses have evolved a number of proteins that function to modulate the apoptotic cascades and thereby favor productive viral replication. One such antiapoptotic protein, myxoma virus M11L, has been shown to inhibit mitochondrial-dependent apoptosis by binding to and blocking the two executioner proteins Bak and Bax. Since M11L has no obvious sequence homology with Bcl-2 or Bcl-x(L), the normal cellular inhibitors for Bak and Bax, and the structure of M11L has not been solved, the mode of binding to Bak and Bax is not known. In order to understand how M11L functions, the crystal structure of M11L was solved to 2.91 A. Despite the lack of sequence similarity, M11L is a structural homolog of Bcl-2. Studies using a peptide derived from Bak indicate that M11L binds to Bak with a similar affinity (4.9 +/- 0.3 microM) to the published binding affinities of Bcl-2 and Bcl-x(L) to the same peptide (12.7 microM and 0.5 microM, respectively), indicating that M11L inhibits apoptosis by mimicking and competing with host proteins for the binding of Bak and Bax. The structure provides important insight into how myxoma virus and other poxviruses facilitate viral dissemination by inhibiting mitochondrial dependent apoptosis.
Perception of Risk and Knowledge of Risk Factors in Women at High Risk for Stroke (2009)

Women were often unable to identify their health condition as a risk factor for stroke. In addition, many women were not undertaking primary prevention behaviors. Risk perception was low, and high-risk women perceived their risk of stroke to be the same as their peers. Educational strategies must advocate for and target high-risk women.
Oncofetal protein IMP3 (2008)

IMP3 is an independent prognostic biomarker that can be used to identify a subgroup of patients with localized papillary and chromophobe RCC who are at high risk for developing distant metastasis.
Configurable, High Throughput, Irregular LDPC Decoder Architecture: Tradeoff Analysis and Implementation (2006)

Low Density Parity Check (LDPC) codes are one of the best error correcting codes that enable the future generations of wireless devices to achieve higher data rates. This paper presents a novel flexible decoder architecture for irregular LDPC codes that supports twelve combinations of code lengths -648, 1296, 1944 bits- and code rates- 1/2, 2/3, 3/4, 5/6- based on the IEEE 802.11n standard. All the codes correspond to a block-structured parity check matrix, in which the sub-blocks are either a shifted identity matrix or a zero matrix. A prototype of the LDPC decoder has been implemented and tested on a Xilinx FPGA and has been synthesized for ASIC.
Hydrothermal reactions in the lime-rich part of the system CaO-SiO2-H2O (1960)

Summary The mineralogy of autoclaved products from various forms of calcium silicate andfrom lime and silica has been investigated. The results are as follows. With a CaO/SiO 2 ratio of 1, the product is always well crystallized tobermorite. With a CaO/SiO 2 ratio of 2, the product varies: starting with lime and silica, dicalcium silicate alpha-hydrate is the first product; this eventually changes into dicalcium silicate beta-hydrate, the stable phase; starting with calcium silicate hydrate I and lime, the first product comprises Flint's CSH(A) and dicalcium silicate alpha-hydrate, and it seems likely that the Flint's CSH(A) will eventually convert to dicalcium silicate alpha-hydrate and the dicalcium silicate alpha-hydrate to dicalcium silicate beta-hydrate; if one starts with β-2CaO.SiO 2 , the product in the first place is dicalcium silicate gamma-hydrate; in the length of processing used in the experiments reported in this paper, no other phase was found, but it is considered that dicalcium silicate gamma-hydrate is only metastable. With a CaO/SiO 2 ratio of 3, again the products vary with the starting minerals: with mixes of lime and silica and with mixes of 2CaO.SiO 2 and lime, the first product is dicalcium silicate alpha-hydrate which is eventually converted to the beta-hydrate; with mixes of calcium silicate hydrate (1) and lime, the product is always Flint's CSH(A) with or without some dicalcium silicate alpha-hydrate; with 3CaO.SiO 2 as the starting material, the product is always 3CaO.SiO 2 .1½H 2 O. It is clear from this work that the form of the starting material has a considerable influence on the nature of the metastable phases produced, and also that, in this part of the system CaO-SiO 2 -H 2 O, even prolonged processing up to 90 days is insufficient to produce true equilibrium phases.
Sweet proteins – Potential replacement for artificial low calorie sweeteners (2005)

Exponential growth in the number of patients suffering from diseases caused by the consumption of sugar has become a threat to mankind's health. Artificial low calorie sweeteners available in the market may have severe side effects. It takes time to figure out the long term side effects and by the time these are established, they are replaced by a new low calorie sweetener. Saccharine has been used for centuries to sweeten foods and beverages without calories or carbohydrate. It was also used on a large scale during the sugar shortage of the two world wars but was abandoned as soon as it was linked with development of bladder cancer. Naturally occurring sweet and taste modifying proteins are being seen as potential replacements for the currently available artificial low calorie sweeteners. Interaction aspects of sweet proteins and the human sweet taste receptor are being investigated.
Measures of lexical diversity in aphasia (2003)

Background: Important to the assessment of aphasia are analyses of discourse production and, in particular, lexical diversity analyses of verbal production of adults with aphasia. Previous researchers have used type-token ratio (TTR) to measure conversational vocabulary in adults with aphasia; however, this measure is known to be sensitive to sample size, requiring that only samples of equivalent length be compared. The number of different words (NDW) is another measure of lexical diversity, but it also requires input samples of equivalent length. An alternative to these measures, D, has been developed (Malvern & Richards, 1997) to address this problem. D allows for comparisons across samples of varying lengths. Aims: The first objective of the current study was to examine the relationships among three measures of productive vocabulary in discourse for adults with aphasia: TTR, NDW, and D. The second objective was to use these measures to determine in what ways, and to what degree, they each can differentiate fluent and nonfluent aphasia. Methods & Procedures: Eighteen adults with aphasia participated in this study (nine with nonfluent aphasia; nine with fluent aphasia). Participants completed the Western Aphasia Battery (WAB) and produced language samples consisting of conversation and picture description. Samples were then subjected to the three lexical diversity analyses. Outcomes & Results: Results indicated that, although the measures generally correlated with each other, adults with fluent aphasia evidenced significantly higher D and NDW values than those with nonfluent aphasia when whole samples were subjected to analyses. Once samples were truncated to 100- and 200-word samples, groups differed significantly for all three measures. Conclusions: These findings add further support to the notion that because TTR and, although to a lesser extent, NDW are sensitive to sample size, length differences across samples tend to confound results. As an alternative to these measures, the use of D for the measurement of conversational vocabulary of adults with aphasia enables the analysis of entire language samples, so that discarding language sample data is not necessary. In the present study, D values differed for fluent and nonfluent aphasia samples.
An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors (1997)

Interactions between the ureteric bud (UB) and metanephric mesenchyme are crucial for tubulogenesis during kidney development. Two immortalized cell lines derived from the day 11.5 embryonic kidney, UB cells, which appear to be epithelial (cytokeratin-positive, E-cadherin-positive, and ZO-1-positive by immunostaining) and BSN cells, which are largely mesenchymal (vimentin-positive, but negative for cytokeratin, cell surface E-cadherin, and cell surface ZO-1), were used to establish an in vitro tubulogenesis system. BSN cells expressed hepatocyte growth factor (HGF) and transforming growth factor-beta1 mRNAs, and its conditioned medium (BSN-CM) contained factors capable of activating the epidermal growth factor (EGF) receptor (EGFR). When UB cells were cultured in an extracellular matrix gel in the presence of the embryonic kidney or BSN-CM, the UB cells underwent morphogenetic changes characteristic of early in vitro branching tubulogenesis. These changes were largely inhibited by a combination of neutralizing anti-HGF antibodies and the EGFR inhibitor tyrphostin AG1478, suggesting that EGFR ligands, together with HGF, account for much of this early morphogenetic activity. Nevertheless, there was a significant fraction of tubulogenic activity that could not be inhibited, suggesting the existence of other soluble factors. Whereas HGF, EGF, transforming growth factor alpha, basic fibroblast growth factor (bFGF), and insulin-like growth factor 1 (IGF-1), or a mixture of these growth factors, induced epithelial processes for up to 3 days, only IGF-1, possibly bFGF, and the mixture were able to sustain morphogenesis for longer periods, though not nearly to the same degree as BSN-CM. Moreover, only BSN-CM induced branching tubular structures with clear lumens, consistent with the existence of other soluble factors crucial for the formation and/or maintenance of branching tubular structures with lumens in vitro.
A Hybrid Strategy for Distributed Generators Islanding Detection (2007)

Distributed generation is a form of electric power privatization. Consumers install their own power station to supply the local loads and/or share in the utility loads. Many protective problems have been developed due to the existence of these distributed generators. However, a protective strategy should be developed to protect the system and the generator itself from different hazards. One of the main protection problems is a generator islanding. Islanding means that the generator becomes in a standalone mode of operation when the utility circuit breaker opens due to either fault occurrence or maintenance. Many techniques of islanding protection are discussed and simulated to make a suitable strategy for the protection of distributed generator. This paper introduces a hybrid passive method for islanding detection to minimize the non-detective zone. This hybrid islanding detection strategy guarantees an accurate operation of the islanding protection relay.
The use of 1-octen-3-ol, acetone and carbon dioxide to improve baits for tsetse flies, Glossina spp. (Diptera: Glossinidae) (1985)

Abstract In Zimbabwe, the catches of Glossina morsitans morsitans Westwood and G. pallidipes Austen in traps were increased by up to three times by releasing 1-octen-3-ol at 0·05–50 mg/h or acetone at 5–5000mg/h near traps, but in some circumstances 1-octen-3-ol at 5–50 mg/h reduced catches. Carbon dioxide at 0·02–20 litres/min increased catches by up to ten times. A mixture of all three chemicals increased the catches by up to 60 times. Each of the three chemicals attracted both species of flies from a distance; carbon dioxide also enhanced trap-entering and alighting responses. Acetone with 1-octen-3-ol can increase by several times the numbers of flies that contact visual baits suitable for exposing them to insecticide. Data for other Diptera are also presented.