gebhart/patrepeval huggingface dataset:
A financial investment assistant (2003)

The analysis of financial markets is a time-consuming complex, and error-prone process. The system described which is still under development, is an attempt to improve this process by partially automating the acquisition, analysis, and selection of financial market investments. The ultimate goal is to fully automate this activity. The current approach is to use technical analysis and fundamental analysis to determine when to buy, sell, or hold various instruments and artificial intelligence techniques to select a portfolio of stocks and/or options based on the goals of the system user. The tool uses a dynamic interface that is reactive to human interaction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Simultaneous measurement of percent carboxyhemoglobin and functional oxygen saturation (2003)

To account for the effect of carboxyhemoglobin on pulse oximeters, the feasibility of simultaneously measuring the functional oxygen saturation and percent carboxyhemoglobin using the pulse oximetry technique was studied. A theoretical model was established, and an in-vitro experiment was carried out. Both the theoretical and experimental results show that the simultaneous measurement is feasible. It was found that the use of 630-nm light gives very good measurement accuracy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Unique stereospecificity of D-amino acid aminotransferase and branched-chain L-amino acid aminotransferase for C-4' hydrogen transfer of the coenzyme (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnique stereospecificity of D-amino acid aminotransferase and branched-chain L-amino acid aminotransferase for C-4' hydrogen transfer of the coenzymeTohru Yoshimura, Katsushi Nishimura, Junko Ito, Nobuyoshi Esakik, Hiroyuki Kagamiyama, James M. Manning, and Kenji SodaCite this: J. Am. Chem. Soc. 1993, 115, 10, 3897–3900Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ja00063a007https://doi.org/10.1021/ja00063a007research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Attenuation of the process of muscle regeneration in the toad gastrocnemius muscle by low energy laser irradiation (1994)

The effect of number, frequency, and timing of HeNe (6.0 mW; 31.2J/cm2) and Ga-As-diode (average power at 2.82 Hz-0.005 mW) laser irradiations on the process of muscle regeneration at 14 days following cold injury to the toad gastrocnemius muscle was investigated using histomorphometric methods. The volume fraction (percent of total injured area) of mononucleated cells, myotubes and degenerated fibers was 10 +/- 1%, 0%, and 4 +/- 1%, respectively, in the HeNe laser irradiated muscles (5 irradiations every alternate day, beginning on the 4th day after injury), whereas in the control nonirradiated muscles, these values were significantly higher comprising 57 +/- 2% (P < 0.01), 11 +/- 1% and 10 +/- 2% (P < 0.05), respectively. The volume fraction of young myofibers in injured areas that were subjected to the same laser irradiation regime was 8.6-fold significantly higher (P < 0.01) than their volume fraction in control muscles. The histomorphometric results were the same for injured zones of muscles that were laser irradiated only once, on the 9th day postinjury, and for those that received five consecutive irradiations every alternate day. Muscle regeneration was equally promoted by single Ga-As-diode laser or HeNe irradiation. Multiple irradiations of Ga-As-diode laser caused some pathological changes in the newly formed muscular structures. It is concluded that the process of skeletal muscle regeneration is markedly promoted by low energy laser irradiations, but that the effect depends on the number, timing, and frequency of irradiations and the type of laser used.
Regenerative Medicine and Organ Transplantation: Past, Present, and Future (2011)

This overview traces the history of regenerative medicine pertinent to organ transplantation, illustrates potential clinical applications reported to date, and highlights progress achieved in the field of complex modular organ engineering. Regenerative medicine can now produce relatively simple tissues such as skin, bladders, vessels, urethras, and upper airways, whereas engineering or generation of complex modular organs remains a major challenge. Ex vivo organ engineering may benefit from complementary investigations in the fields of developmental biology and stem cells and transplantation before its full potential can be realized.
Transcriptome-Wide Identification of Novel Imprinted Genes in Neonatal Mouse Brain (2008)

Imprinted genes display differential allelic expression in a manner that depends on the sex of the transmitting parent. The degree of imprinting is often tissue-specific and/or developmental stage-specific, and may be altered in some diseases including cancer. Here we applied Illumina/Solexa sequencing of the transcriptomes of reciprocal F1 mouse neonatal brains and identified 26 genes with parent-of-origin dependent differential allelic expression. Allele-specific Pyrosequencing verified 17 of them, including three novel imprinted genes. The known and novel imprinted genes all are found in proximity to previously reported differentially methylated regions (DMRs). Ten genes known to be imprinted in placenta had sufficient expression levels to attain a read depth that provided statistical power to detect imprinting, and yet all were consistent with non-imprinting in our transcript count data for neonatal brain. Three closely linked and reciprocally imprinted gene pairs were also discovered, and their pattern of expression suggests transcriptional interference. Despite the coverage of more than 5000 genes, this scan only identified three novel imprinted refseq genes in neonatal brain, suggesting that this tissue is nearly exhaustively characterized. This approach has the potential to yield an complete catalog of imprinted genes after application to multiple tissues and developmental stages, shedding light on the mechanism, bioinformatic prediction, and evolution of imprinted genes and diseases associated with genomic imprinting.
Asymmetric DNA bending in the Cre- loxP site-specific recombination synapse (1999)

Cre recombinase catalyzes site-specific recombination between two 34-bp loxP sites in a variety of DNA substrates. At the start of the recombination pathway, the loxP sites are each bound by two recombinase molecules, and synapsis of the sites is mediated by Cre-Cre interactions. We describe the structures of synaptic complexes formed between a symmetrized loxP site and two Cre mutants that are defective in strand cleavage. The DNA in these complexes is bent sharply at a single base pair step at one end of the crossover region in a manner that is atypical of protein-induced DNA bends. A large negative roll (-49 degrees) and a positive tilt (16 degrees) open the major groove toward the center of the synapse and compress the minor groove toward the protein-DNA interface. The bend direction of the site appears to determine which of the two DNA substrate strands will be cleaved and exchanged in the initial stages of the recombination pathway. These results provide a structural basis for the observation that exchange of DNA strands proceeds in a defined order in some tyrosine recombinase systems. The Cre-loxS synaptic complex structure supports a model in which synapsis of the loxP sites results in formation of a Holliday junction-like DNA architecture that is maintained through the initial cleavage and strand exchange steps in the site-specific recombination pathway.
Design of Sequence-Specific DNA-Binding Molecules (1986)

Base sequence information can be stored in the local structure of right-handed double-helical DNA (B-DNA). The question arises as to whether a set of rules for the three-dimensional readout of the B-DNA helix can be developed. This would allow the design of synthetic molecules that bind DNA of any specific sequence and site size. There are four stages of development for each new synthetic sequence-specific DNA-binding molecule: design, synthesis, testing for sequence specificity, and reevaluation of the design. This approach has produced bis(distamycin)fumaramide, a synthetic, crescent-shaped oligopeptide that binds nine contiguous adenine-thymine base pairs in the minor groove of double-helical DNA.
Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersectionsZhonghui H. Fan and D. Jed. HarrisonCite this: Anal. Chem. 1994, 66, 1, 177–184Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ac00073a029https://doi.org/10.1021/ac00073a029research-articleACS PublicationsRequest reuse permissionsArticle Views1136Altmetric-Citations284LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. (1991)

Considerable evidence suggests that the metabolism of lymphokine mRNAs can be selectively regulated within the cytoplasm. However, little is known about the mechanism(s) that cells use to discriminate lymphokine mRNAs from other mRNAs within the cytoplasm. In this study we report a sequence-specific cytoplasmic factor (AU-B) that binds specifically to AUUUA multimers present in the 3' untranslated region of lymphokine mRNAs. AU-B does not bind to monomeric AUUUA motifs nor to other AU-rich sequences present in the 3' untranslated region of c-myc mRNA. AU-B RNA-binding activity is not present in quiescent T cells but is rapidly induced by stimulation of the T-cell receptor/CD3 complex. Induction of AU-B RNA-binding activity requires new RNA and protein synthesis. Stabilization of lymphokine mRNA induced by costimulation with phorbol myristate acetate correlates inversely with binding by AU-B. Together, these data suggest that AU-B is a cytoplasmic regulator of lymphokine mRNA metabolism.
TLE3 Expression Is Associated with Sensitivity to Taxane Treatment in Ovarian Carcinoma (2012)

Our findings warrant an independent evaluation of TLE3 as a potential therapeutic response marker for taxane-based chemotherapy in ovarian cancer.
Resequencing of messages in communication networks (1986)

In this paper we study a message resequencing problem in a store-and-forward computer network where messages may go out of order while traversing logical channels. The logical channels are assumed to consist of multiple physical links which may be of different capacities. A message is dispatched to the fastest available link. Resequencing methods suggested in the literature [3] (resequencing at the channel level and resequencing at the virtual circuit level) are investigated for this link selection rule. The analysis is done on a two-node network connected by multiple links. The source node together with the set of outgoing links are modeled as an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M/M/m</tex> queue with servers of different rates. The resequencing delay distribution and the average resequencing delay are derived. On multihop networks, the effect of message length, link numbers, link service rates, and the resequencing methods on resequeucing delay are investigated by simulation.
Is there a role for ginger in the treatment of osteoarthritis? (2001)

Donald M. Marcus and Maria E. Suarez-AlmazorOsteoarthritis of the knee and hip are commondisorders that produce chronic pain and disability. Phar-macologic management of pain with analgesics andnonsteroidal antiinflammatory agents (NSAIDs) is notadequate for some people, and NSAIDs may haveserious adverse effects (1). Alternative treatments, suchas acupuncture and herbs, are promoted as gentle,effective, and safe, and many people are exploring theiruse for osteoarthritis and other chronic disorders. Gin-ger is a popular herbal medication whose principal usesinclude treatment of motion sickness, disorders of thegastrointestinal tract, and arthritis (2). The mechanismsof action of ginger are not clear, but there is limitedevidence of inhibition of inflammation in experimentalanimals, and of inhibition of the synthesis of prostaglan-dins and leukotrienes (3).The efficacy and safety of most alternative treat-ments have not been established by controlled trials.Since the use of herbal medications has increased sub-stantially in the last decade, it is imperative that goodscientific evidence be presented to health care profes-sionals and consumers to provide a basis for makinginformed decisions. As reported in this issue of
Total Synthesis of Trioxacarcin DC‐45‐A2 (2015)

Abstract An enantioselective total synthesis of trioxacarcin DC‐45‐A2 ( 1 ) featuring a novel Lewis acid‐induced cascade rearrangement of epoxyketone 6 to forge the polyoxygenated 2,7‐dioxabicyclo[2.2.1]heptane core of the molecule is described.
Highly Phosphorescent Iridium Complexes Containing Both Tridentate Bis(benzimidazolyl)-benzene or -pyridine and Bidentate Phenylpyridine:  Synthesis, Photophysical Properties, and Theoretical Study of Ir-Bis(benzimidazolyl)benzene Complex (2006)

Novel mixed-ligand Ir(III) complexes, [Ir(L)(NwedgeC)X]n+ (L = N/\C/\N or N/\N/\N; X = Cl, Br, I, CN, CH3CN, or -CCPh; n = 0 or 1), were synthesized, where N/\CwedgeN = bis(N-methylbenzimidazolyl)benzene (Mebib) and bis(N-phenylbenzimidazolyl)benzene (Phbib), N/\N/\N = bis(N-methylbenzimidazolyl)pyridine (Mebip), and N/\C = phenylpyridine (ppy) derivatives. The X-ray crystal structures of [Ir(Phbib)(ppy)Cl] and [Ir(Mebib)(mppy)Cl] [mppy = 5-methyl-2-(2'-pyridyl)phenyl] indicate that the nitrogen atom of the ppy ligand is located trans to the coordinating carbon atom in Me- or Phbib, while the coordinating carbon atom in ppy occupies the trans position of Cl. [Ir(Mebip)(ppy)Cl]+ showed a quasireversible Ir(III/IV) oxidation wave at +1.05 V, while the Ir complexes, [Ir(Mebib)(ppy)Cl], were oxidized at +0.42 V versus Fc/Fc+. The introduction of an Ir-C bond in [Ir(Mebib)(ppy)Cl] induces a large potential shift of 0.63 V in a negative direction. Further, the oxidation potential of [Ir(Mebib)(Rppy)X] was altered by the substitution of R, R', and X groups. Compared to the oxidation potential, the first reduction potential revealed an almost constant value at -2.36 to -2.46 V for [Ir(L)(ppy)Cl] (L = Mebib and Phbib) and -1.52 V for [Ir(Mebip)(ppy)Cl. The UV-vis spectra of [Ir(Mebib)(R-ppy)X] show a clear singlet metal-to-ligand charge-transfer transition around 407 approximately 425 nm and a triplet metal-to-ligand charge-transfer transition at 498 approximately 523 nm. [Ir(Mebip)(ppy)Cl]+ emits at 610 nm with a luminescent quantum yield of Phi = 0.16 at room temperature. The phosphorescence of [Ir(Mebib)(ppy)X] was observed at 526 nm for X = CN and 555 nm for X = Cl with the high luminescent quantum yields, Phi = 0.77 approximately 0.86, at room temperature. [Ir(Phbib)(ppy)Cl] shows the emission at 559 nm with a luminescent quantum yield of Phi = 0.95, which is an unprecedentedly high value compared to those of other emissive metal complexes. Compared to the luminescent quantum yields of the Ir(ppy)2(L) derivatives and [Ir(Mebip)(ppy)Cl]+, the neutral Ir complexes, [Ir(L)(R-ppy)X] (L = Me- or Phbib), reveal very high quantum yields and large radiative rate constants (kr) ranging from 3.4 x 10(5) to 5.5 x 10(5) s(-1). The density functional theory calculation suggests that these Ir complexes possess dominantly metal-to-ligand charge-transfer and halide-to-ligand charge-transfer excited states. The mechanism for a high phosphorescence yield in [Ir(bib)(ppy)X] is discussed herein from the perspective of the theoretical consideration of radiative rate constants using perturbation theory and a one-center spin-orbit coupling approximation.
The processing of microcellular foam (1982)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1982.
System for MR Image–guided Prostate Interventions: Canine Study (2003)

The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR imaging unit and enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting and monitoring of prostate interventions. In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved. In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in and around the prostate, thereby confirming that solution had been delivered to the desired tissue and also detecting faulty injections. In the final study, accurate placement and MR imaging of brachytherapy seeds in the prostate were demonstrated. The described system provides a flexible platform for a variety of minimally invasive MR image-guided therapeutic and diagnostic prostate interventions.
Isolation of a nontoxic lipid A fraction containing tumor regression activity. (1981)

Galanos-type endotoxin obtained from the heptose-less mutant of Salmonella typhimurium was converted to Lipid A by two cycles of treatment with sodium acetate, pH 4.5, at 100 degrees and separated on a DEAE-cellulose column into several fractions (Fractions III to VII). Tumor regression studies with strain 2 guinea pigs and syngeneic line 10 hepatocellular carcinoma showed that all fractions were effective when combined with trehalose dimycolates and an additional tumor regression factor (previously designated ACP) and incorporated into oil droplets (78 to 100% cures). A low polar fraction (Fraction IV) was relatively nontoxic [the medium lethal dose for 11-day-old chick embryos inoculated i.v. (CELD50) was more than 10 micrograms] and nonpyrogenic [the dose estimated to give a fever index (area under fever curve) of 40 sq cm in rabbits when 1 hr and 1 degrees are plotted as 1 (FI40) was 5 micrograms] as compared to the unfractionated Lipid A (CELD50 of 0.0546 micrograms; FI40 of 0.046 micrograms). All other fractions were toxic and pyrogenic and caused severe endotoxic shocks when combined with N-acetylmuramyl-L-seryl-D-isoglutamine and injected i.v. into guinea pigs. Fraction IV plus N-acetylmuramyl-L-seryl-D-isoglutamine did not cause endotoxic shock. The phosphate content of Fraction IV was about one-half of that detected in the toxic fractions.
Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease (2001)

This investigation was pursued to test the use of intracellular antibodies (intrabodies) as a means of blocking the pathogenesis of Huntington's disease (HD). HD is characterized by abnormally elongated polyglutamine near the N terminus of the huntingtin protein, which induces pathological protein-protein interactions and aggregate formation by huntingtin or its exon 1-containing fragments. Selection from a large human phage display library yielded a single-chain Fv (sFv) antibody specific for the 17 N-terminal residues of huntingtin, adjacent to the polyglutamine in HD exon 1. This anti-huntingtin sFv intrabody was tested in a cellular model of the disease in which huntingtin exon 1 had been fused to green fluorescent protein (GFP). Expression of expanded repeat HD-polyQ-GFP in transfected cells shows perinuclear aggregation similar to human HD pathology, which worsens with increasing polyglutamine length; the number of aggregates in these transfected cells provided a quantifiable model of HD for this study. Coexpression of anti-huntingtin sFv intrabodies with the abnormal huntingtin-GFP fusion protein dramatically reduced the number of aggregates, compared with controls lacking the intrabody. Anti-huntingtin sFv fused with a nuclear localization signal retargeted huntingtin analogues to cell nuclei, providing further evidence of the anti-huntingtin sFv specificity and of its capacity to redirect the subcellular localization of exon 1. This study suggests that intrabody-mediated modulation of abnormal neuronal proteins may contribute to the treatment of neurodegenerative diseases such as HD, Alzheimer's, Parkinson's, prion disease, and the spinocerebellar ataxias.
Skin-resident memory CD8 + T cells trigger a state of tissue-wide pathogen alert (2014)

After an infection, pathogen-specific tissue-resident memory T cells (T(RM) cells) persist in nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies that create T(RM) cell pools at sites of pathogen entry are therefore attractive. However, it is not well understood how T(RM) cells provide such pathogen protection. Here, we demonstrate that activated T(RM) cells in mouse skin profoundly alter the local tissue environment by inducing a number of broadly active antiviral and antibacterial genes. This "pathogen alert" allows skin T(RM) cells to protect against an antigenically unrelated virus. These data describe a mechanism by which tissue-resident memory CD8(+) T cells protect previously infected sites that is rapid, amplifies the activation of a small number of cells into an organ-wide response, and has the capacity to control escape variants.