gebhart/patrepeval huggingface dataset:
Three-dimensional ultrasound imaging using multiple magnetic tracking systems and miniature magnetic sensors (2002)

The authors have used several configurations of a commercial 6D magnetic position and orientation measurement system to track an ultrasound scanhead and reconstruct 2D ultrasound images in 3D space. They have measured precision and accuracy with two magnetic sensors working in parallel, and with a miniaturized magnetic sensor. The use of two standard size sensors has shown limited improvement in precision (1.5 mm RMS uncertainty compared with 1.8 mm for a single sensor). The miniature sensor has an average precision of 2.1 mm over its operating range. The miniature sensor has been calibrated with an imaging system and has been used in 3D reconstructions of the stomach and the carotid artery.
MENINGITIS CAUSED BY BIFIDOBACTERIUM IN AN INFANT (1988)

Hata, Daisuke M.D.; Yoshida, Akira M.D.; Ohkubo, Hideo M.D.; Mochizuki, Yasuhiro M.D.; Hosoki, Yoshiro M.T.; Tanaka, Ryuichiro Ph.D.; Azuma, Ryozo Ph.D. Author Information
Action of Topically Applied Arachidonic Acid on the Skin of Patients With Psoriasis (1988)

Concentrations of arachidonic acid ranging from 0.1% to 2% were applied under occlusive dressings to psoriatic plaques in 45 patients. Alleviation of the clinical symptoms of psoriasis including complete clearing in some cases was obtained with the use of 0.5% to 2% arachidonic acid applied under occlusion every 24 to 48 hours five to seven times. Histologic examination showed polymorphonuclear leukocytes penetrating into the stratum corneum and formation of microabscesses or wide-spread accumulations of polymorphonuclear leukocytes in the stratum corneum, with its eventual destruction. The parakeratotic horny layer became detached; this was followed by restoration of the granular layer and an apparently normal stratum corneum. While arachidonic acid metabolites can be proinflammatory and proproliferative, they may also be important in the healing process for psoriasis.
Characterization of a novel monoclonal antibody (V58A4) raised against a recombinant NH2‐terminal heparin‐binding fragment of human endothelial cell thrombospondin (1994)

We report herein the characterization of a mouse monoclonal antibody (Mab) raised against the recombinant NH2-terminal heparin-binding domain (rHBD) of human endothelial cell thrombospondin (TSP). The antibody, a IgG1 (kappa), hereafter referred to as V58A4, reacted with two rHBD, TSPN18 and TSPN28 (i.e. 18 kDa and 28 kDa, respectively) with an affinity constant of 1.33 x 10(-8) M. However, V58A4 failed to recognize native or deglycosylated forms of TSP purified from platelets or endothelial cells, as well as a 25-30 kDa HBD fragment produced by limited proteolysis of native TSP. In contrast, Mab V58A4 was shown to react with larger HBD fragments (50-60 kDa) that were present in platelet or endothelial cell extracts and could be retained on a heparin-Sepharose column at low salt concentrations. These fragments also reacted with MA-II, a mouse Mab (IgG1), which recognizes both rHBD and HBD as well as intact TSP. Thus, V58A4 Mab appears to selectively recognize naturally occurring HBD fragments of TSP and may thus prove to be useful for detecting TSP proteolysis in situ under various physiopathological conditions.
Venous Obstruction in Healthy Limbs: A Model for Chronic Compartment Syndrome? (2003)

External venous occlusion of the AT muscles in control subjects induces changes very similar to those of CECS patients, although the different time courses indicate that different processes are involved. The AT compartment of CECS patients is capable of distension.
Permeabilization of ultraviolet-irradiated Chinese hamster cells with polyethylene glycol and introduction of ultraviolet endonuclease from Micrococcus luteus. (1981)

Chinese hamster V-79 cells were made permeable by treatment with polyethylene glycol and then incubated with a Micrococcus luteus extract containing ultraviolet-specific endonuclease activity. This treatment introduced nicks in irradiated, but not in unirradiated, deoxyribonucleic acid. The nicks remained open for at least 3 h; there was no loss of endonuclease-sensitive sites, and no excision of dimers as measured by chromatography was detected. In addition, there was no increase in ultraviolet resistance in treated cells. This suggests that the absence of a significant amount of excision repair in rodent cells is due to the lack of both incision and excision capacity.
Predictors of Clonidine Response in Tourette Syndrome: Implications and Inferences (1996)

Clonidine is an alpha-adrenergic agonist which may alleviate emerging symptoms in Tourette syndrome, an observation that has fueled speculation regarding involvement of stress-sensitive central noradrenergic systems in this disorder. We conducted a retrospective study of 53 juvenile patients with Tourette syndrome to assess predictors of short-term behavioral and tic response to oral clonidine and to examine the relationship, if any, among pretreatment blood pressure, tic severity, and clonidine response. When adverse effects were considered, older subjects experienced a better therapeutic response to clonidine, independent of dose. Improvement in symptoms of attention-deficit hyperactivity disorder was associated with a longer duration of vocal tics before treatment. Baseline sitting diastolic blood pressure was directly correlated with measures of tic severity but not with tic response to clonidine. The findings (1) provide indirect support for involvement of central noradrenergic systems in tic expression; (2) suggest that emergence of a tic-related neurophysiologic dysfunction may be necessary for optimal behavioral response to clonidine in Tourette syndrome; and (3) provide broad guidelines for the clinician considering clonidine therapy for pediatric patients with Tourette syndrome, particularly those with comorbid attention-deficit hyperactivity disorder.
Local Gastric Hypothermia (1963)

The present treatment of massive upper gastrointestinal hemorrhage, regardless of etiology, still carries a disturbingly high mortality. Karlson,<sup>1</sup>comparing 3 generally accepted methods for the therapy of gastroduodenal hemorrhage, found that nonoperation, immediate operation, and selective operation each had a mortality of 14%. Linton and Ellis<sup>2</sup>report that in a series of 65 patients with bleeding esophageal varices secondary to an intrahepatic type of portalbed block, 49% died while preparations for surgery were being made. Peptic disease of the stomach and duodenum and esophageal varices comprise about 80% of the cases of massive acute upper gastrointestinal bleeding.<sup>3</sup>Death in these 2 groups is attributable to uncontrollable hemorrhage, postoperative complications, or hepatic coma. Thus, if exsanguinating hemorrhage could be managed and operation delayed until the patient was in better condition, mortality rates would undoubtedly diminish. Local gastric hypothermia, a recently described modality, may help to accomplish this end.
Combined ketamine and transcranial magnetic stimulation for treatment resistant depression in the context of chronic OCD: a case report (2015)

Treatment resistant depression (TRD) is a major public health issue, with comorbid OCD contributing to the general medical costs and severity associated with TRD. Recent research has investigated the efficacy of transcranial magnetic stimulation (TMS and its variant rTMS) in ameliorating the symptoms of depression and OCD. Most studies have used TMS to facilitate electromagnetic stimulation of the dorsolateral prefrontal cortex, a region implicated in depression, or the supplemental motor area, a region implicated in OCD. However, it is difficult to achieve full remission with TMS alone. A parallel line of research has examined the effects of ketamine, an N-methyl-D-aspartate (NMDA) antagonist, on both depression and OCD. A primary benefit of ketamine is that it provides short-term but rapid relief from certain grave TRD symptoms within approximately two hours. As of yet, little is known about the possible synergistic effects of combined TMS/ketamine for comorbid TRD and OCD. Thus, I report on the case of a 32-year-old male who presented with chronic OCD with somatic fixation, depression, and generalized anxiety disorder, who was treated with a novel combined TMS/ketamine treatment for 12 weeks. Measures of depression and OCD symptoms were administered pre and post treatment. The patient showed significant reductions in depression, but not OCD symptoms, which is consistent with previous research.
Regulation of CD45 engagement by the B-cell receptor CD22. (1995)

The B-cell receptor CD22 binds sialic acid linked alpha-2-6 to terminal galactose residues on N-linked oligosaccharides associated with several cell-surface glycoproteins. The first of these sialoglycoproteins to be identified was the receptor-linked phosphotyrosine phosphatase CD45, which is required for antigen/CD3-induced T-cell activation. In the present work, we examine the effect of interaction between the extracellular domain of CD45 and CD22 on T-cell activation. Using soluble CD22-immunoglobulin fusion proteins and T cells expressing wild-type and chimeric CD45 forms, we show that engagement of CD45 by soluble CD22 can modulate early T-cell signals in antigen receptor/CD3-mediated stimulation. We also show that addition of sialic acid by beta-galactoside alpha-2,6-sialyltransferase to the CD22 molecule abrogates interactions between CD22 and its ligands. Together, these observations provide direct evidence for a functional role of the interaction between the extracellular domain of CD45 and a natural ligand and suggest another regulatory mechanism for CD22-mediated ligand engagement.
Interleukin-6 autoantibodies: possible biological and clinical significance. (1995)

The pleiotropic cytokines, interleukin (IL)-1 alpha, type I interferons and IL-6 also act on cells involved in antibody production. Somehow the immunologic tolerance to these cytokines is often spontaneously broken--even in healthy individuals. Thus, relatively high concentrations of high affinity IgG antibodies against IL-1 alpha and IL-6 frequently occur in the circulation of healthy adults. The autoantibodies specifically antagonize the respective cytokines in vitro. Thermodynamic estimations strongly suggest that autoimmunity can play a significant role in the regulation of certain cytokines. In the light of IL-6 autoantibodies the possible biological and clinical significance of cytokine autoimmunity is discussed.
A Cas9 with Complete PAM Recognition for Adenine Dinucleotides (2018)

CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for genome engineering, but have limited target ranges due to their protospacer adjacent motif (PAM) requirements. We demonstrate a critical expansion of the targetable sequence space for a Type-IIA CRISPR-associated enzyme through identification of the natural 5’-NAA-3’ PAM specificity of a Streptococcus macacae Cas9 (Smac Cas9). We further recombine protein domains between Smac Cas9 and its well-established ortholog from Streptococcus pyogenes (Spy Cas9), as well as an “increased” nucleolytic variant (iSpy Cas9), to achieve consistent mediation of gene modification and base editing. In a comparison to previously reported Cas9 and Cas12a enzymes, we show that our hybrids recognize all adenine dinucleotide PAM sequences and possess robust editing efficiency in human cells.
实时荧光定量PCR（Real—time PCR）方法检测大豆根腐病菌（摘要） (2010)

茄腐镰刀菌（Fusarium solani f.sp．Glycines，FSG）是一种土传真菌病害，主要侵染大豆根部并且引起大豆猝死综合征（sudden death syndrome，SDS），这是一种广泛的、具有破坏性的病害。本研究的目的是开发和使用实时荧光定量PCR（QPCR）来比较30株侵染大豆根部的茄腐镰刀菌（FSG）的DNA含量。根据核编码的线粒体核糖体小亚基RNA基因序列设计特异性引物和探针，用其检测感病大豆品种。发现病原菌株DNA之间存在着显著性差异。
Control Design and Voltage Stability Analysis of a Droop-Controlled Electrical Power System for More Electric Aircraft (2017)

This paper focuses on the analysis of a single dc bus multigenerator electrical power system (EPS) for future more electric aircraft. Within such a single bus paradigm, the paper proposes a detailed control design procedure and provides a stability analysis based on the derivation of the output impedance of the source subsystem and input impedance of the load subsystem, including control dynamics. The single bus characteristic is analyzed and the stability properties of the EPS are investigated when supplying constant power loads. In addition, the paper highlights the impact on stability of the number of parallel sources and of the power sharing ratio. The theoretical analysis is instrumental in designing an optimally stable single dc bus EPS. The key findings are validated by experimental results.
Metabolic properties of Eubacterium pyruvativorans, a ruminal ‘hyper-ammonia-producing’ anaerobe with metabolic properties analogous to those of Clostridium kluyveri (2004)

Eubacterium pyruvativorans I-6(T) is a non-saccharolytic, amino-acid-fermenting anaerobe from the rumen, isolated by its ability to grow on pancreatic casein hydrolysate (PCH) as sole C source. This study investigated its metabolic properties and its likely ecological niche. Additional growth was supported by pyruvate, vinyl acetate, and, to a lesser extent, lactate and crotonate, and also by a mixture of amino acids (alanine, glycine, serine and threonine) predicted to be catabolized to pyruvate. No single amino acid supported growth, and peptides were required for growth on amino acids. Alanine, followed by leucine, serine and proline, were used most extensively during growth, but only alanine and asparate were extensively modified before incorporation. Growth on PCH, but not on pyruvate, was increased by the addition of acetate, propionate and butyrate. l-Lactate was fermented incompletely, mainly to acetate, but no lactate-C was incorporated. Propionate and butyrate were utilized during growth, forming valerate and caproate, respectively. Labelling experiments suggested a metabolic pattern where two C atoms of butyrate, valerate and caproate were derived from amino acids, with the others being formed from acetate, propionate and butyrate. The metabolic strategy of E. pyruvativorans therefore resembles that of Clostridium kluyveri, which ferments ethanol only when the reaction is coupled to acetate, propionate or butyrate utilization. The fermentative niche of E. pyruvativorans appears to be to scavenge amino acids, lactate and possibly other metabolites in order to generate ATP via acetate formation, using volatile fatty acid elongation with C(2) units derived from other substrates to dispose of reducing equivalents.
Development and use of a 293 cell line expressing lac repressor for the rescue of recombinant adenoviruses expressing high levels of rabies virus glycoprotein. (1999)

An expression cassette designed for high-level production of rabies virus glycoprotein (RG) could not be rescued into a replication-defective, adenovirus-based vector using standard procedures. To overcome this difficulty, a 293-based cell line, designated 293LAP13, was constructed that contained and expressed a derivative of the lac repressor protein. The lac operator sequence, to which the repressor binds, was incorporated into an expression cassette, containing a promoter and intron, designed for high-level production of RG. Insertion of a single operator sequence immediately downstream of the transcription start site and the use of the 293LAP13 cell line allowed recombinant viruses that could not be isolated with 293 cells to be rescued efficiently. The operator-containing virus reached higher titres in 293LAP13 than in parental 293 cells and also produced plaques more efficiently in 293LAP13 cells. Moreover, in non-complementing human and canine cell lines, adenovirus vectors with a promoter-intron expression cassette expressed RG at much higher levels than vectors lacking the intron. These observations, together with the demonstration that expression of RG by operator-containing vectors was repressed markedly in 293LAP13 cells and that this inhibition was relieved at least partly by IPTG, suggest that the 293LAP13 cell line may be useful for the rescue and propagation of many vectors in which high expression of the desired protein prevents vector rescue in 293 cells.
An adjustable power management for optimal power saving in LTE terminal baseband modem (2009)

Long term evolution (LTE) of 3GPP provides high bandwidth for data transfer. In the viewpoint of the LTE terminal baseband modem chip, these high data rates require more complex logics and memories than previous baseband modem chips in preceding technologies such as Wideband Code Division Multiple Access (W-CDMA), High Speed Downlink Packet Access (HSDPA), and High Speed Packet Access (HSPA). It may exhaust user equipment (UE)'s battery power quickly. Thus, LTE provides an enhanced discontinuous reception (DRX) to extend the UE's battery lifetime. In this work, we propose an adjustable power management using a hierarchical cascaded power gating (HCPG) and a hierarchical multi-level clock gating (HMLCG) with special regard for DRX framework. The test results from the designed ASIC show that optimal power saving was achieved by using the proposed adjustable power management.
Synthesis of α-Norbornenylpoly(ethylene oxide) Macromonomers and Their Ring-Opening Metathesis Polymerization (1996)

This work focuses on the synthesis and the ring-opening metathesis polymerization of α-norbornenylpoly(ethylene oxide) macromonomers. Although obtained in 100% yield and with a narrow distribution of molar masses, the polymacromonomers exhibit degrees of polymerization that are systematically higher than expected. The reasons for this feature are thoroughly discussed.
Assembly of the Human Origin Recognition Complex (2001)

The six-subunit origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae. Yeast ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors, such as Cdc6 and the Mcm proteins. Human homologues of all six ORC subunits have been identified by sequence similarity to their yeast counterparts, but little is known about the biochemical characteristics of human ORC (HsORC). We have extracted HsORC from HeLa cell chromatin and probed its subunit composition using specific antibodies. The endogenous HsORC, identified in these experiments, contained homologues of Orc1-Orc5 but lacked a putative homologue of Orc6. By expressing HsORC subunits in insect cells using the baculovirus system, we were able to identify a complex containing all six subunits. To explore the subunit-subunit interactions that are required for the assembly of HsORC, we carried out extensive co-immunoprecipitation experiments with recombinant ORC subunits expressed in different combinations. These studies revealed the following binary interactions: HsOrc2-HsOrc3, HsOrc2-HsOrc4, HsOrc3-HsOrc4, HsOrc2-HsOrc6, and HsOrc3-HsOrc6. HsOrc5 did not form stable binary complexes with any other HsORC subunit but interacted with sub-complexes containing any two of subunits HsOrc2, HsOrc3, or HsOrc4. Complex formation by HsOrc1 required the presence of HsOrc2, HsOrc3, HsOrc4, and HsOrc5 subunits. These results suggest that the subunits HsOrc2, HsOrc3, and HsOrc4 form a core upon which the ordered assembly of HsOrc5 and HsOrc1 takes place. The characterization of HsORC should facilitate the identification of human origins of DNA replication.
INSPECTOR: A Computer Vision System that Learns to Inspect Parts (1983)

A computer vision inspection system has been developed that learns the difference between good and bad parts by being shown several identified good and bad parts. The model, formed during the training session, contains identifying points which are used for locating parts and inspection tests which apply only to pertinent regions of the part. Using the model, the system can distinguish between good parts and bad parts with an arbitrary number of defects. It can also learn to classify parts if it is shown the different parts during the training session. Examples of INSPECTOR inspecting industrial parts are shown.
Reconstitution of adhesive properties of human platelets in liposomes carrying both recombinant glycoproteins Ia/IIa and Ibα under flow conditions: specific synergy of receptor–ligand interactions (2002)

Liposomes carrying both recombinant glycoprotein Ia/IIa (rGPIa/IIa) and Ib alpha (rGPIb alpha) (rGPIa/IIa-Ib alpha-liposomes) instantaneously and irreversibly adhered to the collagen surface in the presence of soluble von Willebrand factor (VWF) at high shear rates, in marked contrast with translocation of liposomes carrying rGPIb alpha alone on the VWF surface. In the absence of soluble VWF, the adhesion of rGPIa/IIa-Ib alpha-liposomes to the collagen surface decreased with increasing shear rates, similar to liposomes carrying rGPIa/IIa alone. While adhesion of liposomes with exofacial rGPIa/IIa and rGPIb alpha densities of 2.17 x 10(3) and 1.00 x 10(4) molecules per particle, respectively, was efficient at high shear rates, reduction in rGPIb alpha density to 5.27 x 10(3) molecules per particle resulted in decreased adhesion even in the presence of soluble VWF. A 50% reduction in the exofacial rGPIa/IIa density resulted in a marked decrease in the adhesive ability of the liposomes at all shear rates tested. The inhibitory effect of antibody against GPIb alpha (GUR83-35) on liposome adhesion was greater at higher shear rates. Further, the anti-GPIa antibody (Gi9) inhibited liposome adhesion more than GUR83-35 at all shear rates tested. These results suggest that the rGPIa/IIa-collagen interaction dominates the adhesion of rGPIa/IIa-Ib alpha-liposomes to the collagen surface at low shear rates, while the rGPIa/IIa-collagen and rGPIb alpha-VWF interaction complements each other, and they synergistically provide the needed functional integration required for liposome adhesion at high shear rates. This study thus has confirmed for the first time the proposed mechanisms of platelet adhesion to the collagen surface under flow conditions using the liposome system.
New anabolic therapies in osteoporosis (2002)

While antiresorptive drugs have been the cornerstone of osteoporosis therapy, anabolic drugs are an important new advance in the treatment of osteoporosis. By directly stimulating bone formation, anabolic agents might have greater potential than the antiresorptives to increase bone mass and to decrease fractures. It is also possible that the combination of an antiresorptive agent with an anabolic agent could be more potent than either agent alone. Potential anabolic therapies for osteoporosis, including fluoride, growth hormone, insulin-like growth factor-I, strontium, and parathyroid hormone, are reviewed here. Of these, parathyroid hormone has clearly emerged as the most promising treatment at this time.
Against the grain: Prejudice and ignorance in timber conservation (1988)

If there is one thing that stands out in any overview of the conservation of timber structures in Australia, it is that they are the poor relations. We have been slow to recognise them and take them seriously. We have not understood them well. We have not, by and large, been able to research them in anything approaching a satisfactory way. We have not known how to treat them. So to speak about prejudice and ignorance in timber conservation is not to criticise conservationists; it is to speak about a prejudice which is general in the community and about a degree of ignorance which is inevitably found, even amongst conservationists, as a result of that community prejudice.