gebhart/patrepeval huggingface dataset:
Identification of a Family of Muscarinic Acetylcholine Receptor Genes (1987)

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.
Tactics for Managing Pesticide Resistance in Arthropods: Theory and Practice (1992)

The evolution of resistance to insecticides and acaricides by arthropod pests can be viewed and studied from two contrasting perspectives. At a fun­ damental level, resistance provides an almost ideal model of adaptation to withstand severe environmental stress. Work on the genetic (127, 128), biochemical (30, 82), and more recently, the molecular basis of resistance mechanisms (32) has cast light on the nature of this adaptation in several insect species, leading in some cases to diagnostic assays for specific genes or gene products (3, 22, 45). Similarly, population geneticists have exploited opportunities to analyze the selection of resistance in laboratory and field experiments (94, 95), and to predict, using theoretical models, how fast resistance genes are likely to evolve under different pesticide exposure re­ gimes ( l lS, 120). Unlike most evolutionary phenomena, however, resistance is also of great practical and economic significance. Not only have resistant species increased greatly in number (56), but the severity and extent of some resistance prob­ lems has increased alarmingly. For example, in some populations of the diamondback moth, Plutella xylostella (6), and Colorado potato beetle, Lepti­ notarsa decemlineata (50), resistance to virtually all available insecticides has
Abstract 572: Large Solid Organ Perfusion Decellularization - A Start for Human-Sized Tissue Scaffolds? (2007)

Background . Tissue engineering involves at a minimum cells and scaffold. However, reports of generating human-sized 3-dimensional scaffolds with appropriate architecture are limited. We hypothesize that perfusion decellularization of cadaveric pig solid organs will effectively remove cellular components and DNA, potentially providing a sufficient starting point for whole solid-organ tissue engineering. Methods . Adult Yorkshire swine (~60kg) were euthanized after systemic heparinization. Heart, liver, and kidneys were removed and mounted on a perfusion apparatus. Cannulation was performed using either the aorta (heart), portal vein (liver), or renal artery (kidney). Saline at 25C was perfused to remove blood, followed by Sodium Dodecyl Sulfate (SDS) detergent perfusion until tissues were translucent and white in color (heart=40 liters; liver=19 liters; kidney=31 liters). SDS was followed by 2 liters of 1% Triton-X 100 to sequester remaining detergent via micelle formation and clearance. Decellularization was evaluated by histology (H&amp;E, DAPI, IHC). Tissue DNA content post-decellularization was quantified using a Hoechst-33258 DNA assay. Results . By histology, heart, liver, and kidney lacked intracellular components and DAPI, but retained major ECM proteins (fibronectin, collagen, and laminin). DNA in decellularized tissue was &lt;2.2% of cadaveric controls by wet weight for all organs (heart=16.0 ± 2.9 vs. control=762.6 ± 48.5 ng/mg; liver=3.6 ± 0.7 vs. control=1157.6 ±91.7 ng/mg; kidney=25.2 ± 1.7 vs. control=1380.0 ± 201.2 ng/mg). Conclusion . SDS-based perfusion decellularization of large animal organs is effective at removing cellular content and DNA. The remaining whole-organ scaffold provides a platform technology for a novel construct for tissue engineering of human sized bioartificial organs.
NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10 (2015)

Recently, dysregulation of microRNAs plays a critical role in cancer metastasis. Here, an in vivo selection approach was used to generate highly aggressive NSCLC sub-cell lines followed by comparing the microRNAs expression using microarrays. miR-124 was notably deregulated in both highly invasive sub-cell lines and node-positive NSCLC specimens. Over-expression of miR-124 robustly attenuated migration and metastatic ability of the aggressive cells. MYO10 was subsequently identified as a novel functional downstream target of miR-124, and was up-regulated in node-positive NSCLC tissues. Knockdown of MYO10 inhibited cell migration, whereas forced MYO10 expression markedly rescued miR-124-mediated suppression of cell metastasis. Additionally, we found an activated NF-κB-centered inflammatory loop in the highly aggressive cells leading to down-regulation of miR-124. These results suggest that NF-κB-regulated miR-124 targets MYO10, inhibits cell invasion and metastasis, and is down-regulated in node-positive NSCLC.
A Multicenter Phase II Study of Docetaxel in Combination with Gefitinib in Gemcitabine-Pretreated Patients with Advanced/Metastatic Pancreatic Cancer (2006)

The docetaxel/gefitinib combination, although safe, has no activity as salvage treatment for advanced pancreatic cancer after failure of gemcitabine-based chemotherapy.
ChemInform Abstract: NEW REACTION OF 3,6‐BIS(2‐PYRIDYL)‐1,2,4,5‐TETRAZINE WITH ANHYDRO BASE OF 1,2,3‐TRIMETHYLQUINOXALINIUM AND INTRAMOLECULAR AMINOLYSIS OF THE RESULTING AZOMETHINE (1981)

Abstract Durch Einwirkung des Tetrazinderivates (I) auf die Anhydrobase (II) von 1,2,3‐Trimethyl‐chinoxalin (II) (entstanden in situ aus dem Methoiod‐id von 2,3‐Dimethylchinoxalin bei Zugabe von Triethylamin) erhält man unter Stickstoff‐Abspaltung das Azomethin (III).
Reduced-size branch-line and rat-race hybrids for uniplanar MMIC's (1990)

A method of miniaturizing branch-line 90 degrees hybrids and 180 degrees rat-race hybrids is proposed. The method utilizes combinations of short high-impedance transmission lines and shunt lumped capacitors. The hybrids were fabricated on GaAs substrates and the validity and effectiveness of the method were confirmed through experiments at 25 GHz and 11 GHz. The fabricated hybrids demonstrate excellent design accuracy at high frequencies, with a circuit size that is more than 80% smaller than that of conventional hybrids. These hybrids are particularly suitable for uniplanar MMICs where necessary shunt connections are easily made.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide. (1995)

The identification of antigenic peptides presented on the tumor cell surface by HLA class I molecules and recognized by tumor-specific cytotoxic T lymphocytes may lead to a peptide vaccine capable of inducing protective cellular immunity. We demonstrate that both HLA-A2-restricted breast and ovarian tumor-specific cytotoxic T lymphocytes recognize shared antigenic peptides. At least one of these peptides is derived from the oncogene product of HER2/neu, which is overexpressed in 30-40% of all breast and ovarian cancers. T cells sensitized against this nine-amino acid sequence demonstrate significant recognition of HLA-A2+, HER2/neu+ tumors. Since 50% of the tumor-cell population is HLA-A2+ and many different tumors express HER2/neu, this peptide may be widely recognized and have many clinical applications.
Tank Mixing Saflufenacil, Glufosinate, and Indaziflam Improved Burndown and Residual Weed Control (2013)

Saflufenacil and indaziflam, POST and PRE herbicides, respectively, have been registered recently for weed control in Florida citrus. Glufosinate is under evaluation and may be registered in the future for POST weed control in citrus. Citrus growers often want to have a tank mixture of herbicides that provide broad-spectrum weed control. Saflufenacil is a broadleaf herbicide and needs to be tank mixed with other herbicide(s) to increase weed control spectrum. Information is not available on interaction of saflufenacil, glufosinate, and indaziflam applied in tank mixtures on weed control efficacy. Greenhouse and field experiments were conducted at two locations (Polk and Orange County, FL) to evaluate the efficacy and potential antagonism or synergy of saflufenacil and glufosinate applied in tank mixes, and various three-way mixes with indaziflam. The results suggested that tank mixing saflufenacil with glufosinate had no effect on grass weed control, but had additive effect on broadleaf weed control. Indaziflam tank mixed at the recommended label rate (0.073 kg ha −1 ) provided better residual weed control compared with the lower rate (0.05 kg ha −1 ). Tank mixing indaziflam with saflufenacil and glufosinate improved broadleaf and grass weed control, reduced weed density, and biomass compared with tank mixing saflufenacil and glufosinate. Tank mixing indaziflam at 0.073 kg ha −1 with saflufenacil and glufosinate provided ≥ 88% control of broadleaf and grass weeds at 30 d after treatment (DAT), and it was comparable with tank mixing saflufenacil, glyphosate and pendimethalin. This treatment combination recorded the lowest weed density (≤ 7 plants m −2 ) and biomass (&lt; 80 g m −2 ) at 60 DAT. Glyphosate applied alone was less effective than tank mixing with saflufenacil and glufosinate for broadleaf and grass weed control. This indicates additive effect of tank mixture on glyphosate efficacy. It is concluded that saflufenacil can be tank mixed with glufosinate for control of broadleaf and grass weeds; however, addition of indaziflam in tank mixture provided long-term, broad-spectrum weed control in Florida citrus compared with other treatments.
Everyday Eye Contact Detection Using Unsupervised Gaze Target Discovery (2017)

Eye contact is an important non-verbal cue in social signal processing and promising as a measure of overt attention in human-object interactions and attentive user interfaces. However, robust detection of eye contact across different users, gaze targets, camera positions, and illumination conditions is notoriously challenging. We present a novel method for eye contact detection that combines a state-of-the-art appearance-based gaze estimator with a novel approach for unsupervised gaze target discovery, i.e. without the need for tedious and time-consuming manual data annotation. We evaluate our method in two real-world scenarios: detecting eye contact at the workplace, including on the main work display, from cameras mounted to target objects, as well as during everyday social interactions with the wearer of a head-mounted egocentric camera. We empirically evaluate the performance of our method in both scenarios and demonstrate its effectiveness for detecting eye contact independent of target object type and size, camera position, and user and recording environment.
Comparison of Biofeedback Pulse Wave Velocity and Progressive Relaxation in Essential Hypertensives (1977)

In a study undertaken to evaluate the clinical effectiveness of two behavioral treatments for essential hypertension (biofeedback on arterial pulse-wave velocity and progressive relaxation) 24 hypertensive subjects were randomly assigned to either a relaxation or biofeedback treatment group for 5 weekly sessions. In a second stage of the study 16 of the original subjects received both biofeedback and relaxation treatments during 5 additional weekly sessions. Results indicated that biofeedback and relaxation were equally effective in initial lowering of blood pressure in hypertensives. Although biofeedback training lead to superior reductions at the 3-mo. follow-up point, after 1 yr. the blood pressures of both groups were not only equal but well below those presented at the beginning of the study.
Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1. (1992)

Early events in both T-cell receptor (CD3)- and CD4-induced signal transduction pathways include tyrosine phosphorylation of protein substrates, the generation of phosphatidylinositol-phosphate breakdown products, and the mobilization of intracellular Ca2+. Oxidative stress in T cells mediated by sulfhydryl-reactive nonpolar maleimides was shown previously to down-regulate both receptor-mediated Ca2+ mobilization and interleukin 2 production. Here we show that N-ethylmaleimide suppresses both CD3- and CD4-induced Ca2+ responses in human T cells correlating with a reduction in the level of phospholipase C gamma 1 (PLC gamma 1) tyrosine phosphorylation. The inhibition of tyrosine phosphorylation of PLC gamma 1 and additional protein substrates was observed at concentrations of N-ethylmaleimide above 20 microM, whereas lower concentrations of oxidant appeared to increase tyrosine kinase activity following cell stimulation. Sulfhydryl oxidation did not directly affect the catalytic activity of PLC gamma 1, since immunopurified enzyme from N-ethylmaleimide-treated T cells was fully active. Although N-ethylmaleimide treatment of T cells did not cause a direct effect on total pp56lck kinase activity measured in vitro, the interaction between CD4 and pp56lck was oxidation-sensitive in vivo. However, CD3-induced signaling was inhibited at N-ethylmaleimide concentrations lower than that required for CD4/pp56lck dissociation, suggesting that CD3-associated tyrosine kinase activity involves acutely sensitive regulatory thiols. In addition to chemically induced sulfhydryl oxidation, naturally regulated cellular redox states appear to dictate the potential for T-cell responsiveness, since degranulating human peripheral blood neutrophils inhibited CD3-induced Ca2+ mobilization in T lymphocytes. These data indicate that signal transduction in T cells involves the activation of PLC gamma 1 by tyrosine phosphorylation through an oxidation-sensitive intermediate between surface receptors and tyrosine kinases, perhaps including the interaction between CD4 and pp56lck.
Template based recovery of Fourier-based watermarks using log-polar and log-log maps (2003)

Digital watermarks have been proposed as a method for discouraging illicit copying and distribution of copyrighted material. The paper describes a method for the secure and robust copyright protection of digital images. We present an approach for embedding a digital watermark into an image using the fast Fourier transform. To this watermark is added a template in the Fourier transform domain, to render the method robust against rotations and scaling, or aspect ratio changes. We detail an algorithm based on the log-polar or log-log maps for the accurate and efficient recovery of the template in a rotated and scaled image. We also present results which demonstrate the robustness of the method against some common image processing operations such as compression, rotation, scaling and aspect ratio changes.
The Role of Calcium in the Desensitization of Capsaicin Responses in Rat Dorsal Root Ganglion Neurons (1997)

Capsaicin (Cap) is a pungent extract of the Capsicum pepper family, which activates nociceptive primary sensory neurons. Inward current and membrane potential responses of cultured neonatal rat dorsal root ganglion neurons to capsaicin were examined using whole-cell and perforated patch recording methods. The responses exhibited strong desensitization operationally classified as acute (diminished response during constant Cap exposure) and tachyphylaxis (diminished response to successive applications of Cap). Both acute desensitization and tachyphylaxis were greatly diminished by reductions in external Ca2+ concentration. Furthermore, chelation of intracellular Ca2+ by addition of either EGTA or bis(2-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid to the patch pipette attenuated both forms of desensitization even in normal Ca2+. Release of intracellular Ca2+ by caffeine triggered acute desensitization in the absence of extracellular Ca2+, and barium was found to effectively substitute for calcium in supporting desensitization. Cap activated inward current at an ED50 of 728 nM, exhibiting cooperativity (Hill coefficient, 2.2); however, both forms of desensitization were only weakly dependent on [Cap], suggesting a dissociation between activation of Cap-sensitive channels and desensitization. Removal of ATP and GTP from the intracellular solutions resulted in nearly complete tachyphylaxis even with intracellular Ca2+ buffered to low levels, whereas changes in nucleotide levels did not significantly alter the acute form of desensitization. These data suggest a key role for intracellular Ca2+ in desensitization of Cap responses, perhaps through Ca2+-dependent dephosphorylation at a locus that normally sustains Cap responsiveness via ATP-dependent phosphorylation. It also seems that the signaling mechanisms underlying the two forms of desensitization are not identical in detail.
Improving Resource Efficiency at Scale with Heracles (2016)

User-facing, latency-sensitive services, such as websearch, underutilize their computing resources during daily periods of low traffic. Reusing those resources for other tasks is rarely done in production services since the contention for shared resources can cause latency spikes that violate the service-level objectives of latency-sensitive tasks. The resulting under-utilization hurts both the affordability and energy efficiency of large-scale datacenters. With the slowdown in technology scaling caused by the sunsetting of Moore’s law, it becomes important to address this opportunity. We present Heracles, a feedback-based controller that enables the safe colocation of best-effort tasks alongside a latency-critical service. Heracles dynamically manages multiple hardware and software isolation mechanisms, such as CPU, memory, and network isolation, to ensure that the latency-sensitive job meets latency targets while maximizing the resources given to best-effort tasks. We evaluate Heracles using production latency-critical and batch workloads from Google and demonstrate average server utilizations of 90% without latency violations across all the load and colocation scenarios that we evaluated.
Post-traumatic Stress (2012)

Unexpected extreme sudden traumatic stressor may cause post-traumatic stress disorder (PTSD). Important traumatic events include war, violent personal assault (e.g., sexual assault, and physical attack), being taken hostage or kidnapped, confinement as a prisoner of war, torture, terrorist attack, severe car accidents, and natural disasters. In childhood age sexual abuse or witnessing serious injuries or unexpected death of a beloved one are among important traumatic events. PTSD can be categorized into two types of acute and chronic PTSD: if symptoms persist for less than three months, it is termed “acute PTSD,” otherwise, it is called “chronic PTSD.” 60.7% of men and 51.2% of women would experience at least one potentially traumatic event in their lifetime. The lifetime prevalence of PTSD is significantly higher in women than men. Lifetime prevalence of PTSD varies from 0.3% in China to 6.1% in New Zealand. The prevalence of PTSD in crime victims are between 19% and 75%; rates as high as 80% have been reported following rape. The prevalence of PTSD among direct victims of disasters was reported to be 30%–40%; the rate in rescue workers was 10%–20%. The prevalence of PTSD among police, fire, and emergency service workers ranged from 6%–32%. An over all prevalence rate of 4% for the general population, the rate in rescue/recovery occupations ranged from 5% to 32%, with the highest rate reported in search and rescue personnel (25%), firefighters (21%), and workers with no prior training for facing disaster. War is one of the most intense stressors known to man. Armed forces have a higher prevalence of depression, anxiety disorders, alcohol abuse and PTSD. High-risk children who have been abused or experienced natural disasters may have an even higher prevalence of PTSD than adults. Female gender, previous psychiatric problem, intensity and nature of exposure to the traumatic event, and lack of social support are known risk factors for work-related PTSD. Working with severely ill patients, journalists and their families, and audiences who witness serious trauma and war at higher risk of PTSD. The intensity of trauma, pre-trauma demographic variables, neuroticism and temperament traits are the best predictors of the severity of PTSD symptoms. About 84% of those suffering from PTSD may have comorbid conditions including alcohol or drug abuse; feeling shame, despair and hopeless; physical symptoms; employment problems; divorce; and violence which make life harder. PTSD may contribute to the development of many other disorders such as anxiety disorders, major depressive disorder, substance abuse/dependency disorders, alcohol abuse/dependence, conduct disorder, and mania. It causes serious problems, thus its early diagnosis and appropriate treatment are of paramount importance.
Learning from Bullying Traces in Social Media (2012)

We introduce the social study of bullying to the NLP community. Bullying, in both physical and cyber worlds (the latter known as cyberbullying), has been recognized as a serious national health issue among adolescents. However, previous social studies of bullying are handicapped by data scarcity, while the few computational studies narrowly restrict themselves to cyberbullying which accounts for only a small fraction of all bullying episodes. Our main contribution is to present evidence that social media, with appropriate natural language processing techniques, can be a valuable and abundant data source for the study of bullying in both worlds. We identify several key problems in using such data sources and formulate them as NLP tasks, including text classification, role labeling, sentiment analysis, and topic modeling. Since this is an introductory paper, we present baseline results on these tasks using off-the-shelf NLP solutions, and encourage the NLP community to contribute better models in the future.
Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. (1994)

Oral tolerance was generated to hen egg white lysozyme in the mouse or to guinea pig myelin basic protein in the rat by a low-dose (1 mg) or a high-dose (5-20 mg) feeding regimen. High doses of antigen induced tolerance characterized by anergy with little or no active suppression and increased secretion of interleukin 4 (IL-4). Anergy was shown by an increase in frequency of IL-2-secreting cells following culture in recombinant IL-2. Low doses of antigen induced tolerance characterized by antigen-driven active suppression with increased secretion of transforming growth factor beta (TGF-beta) and IL-4 and minimal anergy. Without further immunization, spleen cells from animals orally tolerized by both regimens secreted increased levels of IL-4 and TGF-beta in an antigen-specific manner. Animals fed high doses secreted more IL-4 and less TGF-beta, whereas those fed low doses secreted more TGF-beta and less IL-4. These results demonstrate that the two feeding regimens induced cell populations that differed in their cytokine secretion profile and their capacity to actively suppress in vitro and to induce anergy. Our results provide a basis for distinguishing different forms of antigen-driven peripheral tolerance and have important implications for orally induced antigen-specific modulation of human autoimmune diseases.