gebhart/patrepeval huggingface dataset:
Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides. (1979)

A clone (AE1) of cells resistant to adenosine cytotoxicity was isolated from a mutagenized population of mouse T-lymphoma (S49) cells. These adenosine-resistant cells cannot transport adenosine or any other purine or pyrimidine nucleoside tested, but their transport of purine bases is intact. The AE1 cells also have an impaired ability to salvage thymidine. Kinetic analyses of the uptake of purine and pyrimidine nucleosides further substantiate the evidence that the facilitated transport of purine and pyrimidine nucleosides in S49 cells is mediated by the same carrier. Growth rate and transport studies indicate that the lack of expression of the nucleoside transport in AE1 cells is recessive in intraspecies cell-cell hybrids.
Input characteristics of a chopped multi-path current feedback instrumentation amplifier (2011)

This paper presents simulations and measurements of the input impedance, input bias and offset current of a chopped multi-path current feedback instrumentation amplifier. In precision applications, these parameters, together with a finite impedance source can lead to significant measurement errors. In this paper, design strategies to minimize these errors are provided. At a chopping frequency of 30 kHz, the proposed amplifier has an input impedance of 6 MΩ, with bias and offset currents of 102pA and 43pA, respectively. In addition, it achieves low noise (21nV/√Hz), low (2 μV) input-referred offset, high common-mode rejection ratio (134dB) and high power supply rejection ratio (120dB).
<title>Influence of polymer properties on airborne chemical contamination of chemically amplified resists</title> (1993)

We describe here an extensive study of the relation between polymer structure and rates of NMP uptake for a set of polymer films with a very broad range of properties. NMP labeled using radioactive <SUP>14</SUP>C was introduced at a concentration of 12 ppb into a stream of purified air. The film of interest was then immersed in the airstream for a predetermined time under controlled conditions. The radionuclide serves as a tag which allows precise quantitation of NMP absorbed by the polymer film. NMP uptake rates measured using this method are shown to correlate with polymer physical properties in a straightforward manner. The observed trends are in accord with those expected on the basis of the solution diffusion model of polymer permeation. These data provide a basis for the rational design of polymers for chemically amplified resists which are insensitive to airborne contaminants.
Vehicles capable of dynamic vision (1997)

Survey of artificial intelligence applications to vehicular computer vision including aircraft and ground vehicles
Encyclopedia of Analytical Chemistry (2006)

Multidimensional (MD) separation is a combination of two or more separation techniques that increases peak capacity. There are two requirements or criteria in MD as suggested by Giddings. First is orthogonality, which means that the separation mechanism in each step must be based on different molecular properties such as size, charge, hydrophobicity, or chirality. Second is that the separation obtained in the first dimension must be preserved in the subsequent dimensions. There are two types of MD separation, comprehensive and heart cutting. In the first type, all compounds present in the mixture are separated and detected, while in the second, only selected fractions in the mixture are analyzed. The connection between the dimensions that must be tight and dead-volume free is the most important part of an MD separation system. The most common connection was an interface that joins two or more chromatographic columns and/or electrophoretic capillaries. In the case of capillary electrophoresis (CE), there is an alternative strategy to obtain MD separations without the use of an interface. This is the so-called heart-cutting MD-CE in a single capillary or interface-free MD-CE. In interface-free MD-CE, mobilization of fractions between dimensions is achieved by manipulation of voltage and/or pressure. Although MD-CE has been developed for more than 15 years, applications to real samples were not as prevalent as those reported for MD gas and liquid chromatography. MD-CE research reports were on tighter interfaces development as well as sensitivity and performance enhancements in two-dimension format (2D-CE). This article is devoted to the wide range of interfaces and interface/interface-free methods developed for 2D-CE. CE separation modes used in 2D-CE were also briefly discussed for readers not familiar with CE.
A post-processing system to yield reduced word error rates: Recognizer Output Voting Error Reduction (ROVER) (2002)

Describes a system developed at NIST to produce a composite automatic speech recognition (ASR) system output when the outputs of multiple ASR systems are available, and for which, in many cases, the composite ASR output has a lower error rate than any of the individual systems. The system implements a "voting" or rescoring process to reconcile differences in ASR system outputs. We refer to this system as the NIST Recognizer Output Voting Error Reduction (ROVER) system. As additional knowledge sources are added to an ASR system (e.g. acoustic and language models), error rates are typically decreased. This paper describes a post-recognition process which models the output generated by multiple ASR systems as independent knowledge sources that can be combined and used to generate an output with reduced error rate. To accomplish this, the outputs of multiple of ASR systems are combined into a single, minimal-cost word transition network (WTN) via iterative applications of dynamic programming (DP) alignments. The resulting network is searched by an automatic rescoring or "voting" process that selects the output sequence with the lowest score.
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression (1997)

The adeno-associated virus 2 (AAV), a single-stranded DNA-containing, nonpathogenic human parvovirus, has gained attention as a potentially useful vector for human gene therapy. However, the single-stranded nature of the viral genome significantly impacts upon the transduction efficiency, because the second-strand viral DNA synthesis is the rate-limiting step. We hypothesized that a host-cell protein interacts with the single-stranded D sequence within the inverted terminal repeat structure of the AAV genome and prevents the viral second-strand DNA synthesis. Indeed, a cellular protein has been identified that interacts specifically and preferentially with the D sequence at the 3' end of the AAV genome. This protein, designated the single-stranded D-sequence-binding protein (ssD-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells by inhibiting the leading strand viral DNA synthesis. Inhibition of cellular protein tyrosine kinases by genistein results in dephosphorylation of the ssD-BP, leading not only to significant augmentation of transgene expression from recombinant AAV but also to autonomous replication of the wild-type AAV genome. Dephosphorylation of the ssD-BP also correlates with adenovirus infection, or expression of the adenovirus E4orf6 protein, which is known to induce AAV DNA replication and gene expression. Thus, phosphorylation state of the ssD-BP appears to play a crucial role in the life cycle of AAV and may prove to be an important determinant in the successful use of AAV-based vectors in human gene therapy.
Exocrine Pancreatic Proteins in Serum During Pancreatic Allograft Rejection (1994)

The serum concentrations of immunoreactive pancreatic secretory trypsin inhibitor, cationic elastase, anionic trypsin, cationic trypsin, and total amylase activity, were studied after pancreatic allograft transplantation. Nine patients received whole organ pancreaticoduodenal allografts with exocrine drainage to the bladder. Eight of the patients received simultaneously a renal allograft. The serum concentration of immunoreactive cationic elastase increased gradually during the first postoperative days to a peak on the fifth day after surgery; all other proteins decreased in concentration after the first day. Eighteen episodes of pancreatic and/or kidney rejection, diagnosed by means of kidney biopsy, urinary cytology, kidney function, and urinary amylase levels, were analyzed. The pancreatic proteins displayed different patterns in serum concentration during the days immediately before diagnosis of rejection. The pancreatic secretory trypsin inhibitor showed the most pronounced peak in serum concentration during rejection and even reacted during some episodes without a decline in urinary amylase output. Cationic elastase on the other hand showed no reaction at all. From this homogeneous material it is possible to conclude that changes in serum concentrations during rejection are not the same for all pancreatic exocrine proteins.
One-Pot Synthesis of Glucosamine Oligosaccharides (2001)

[reaction: see text] Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner. One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50-81% yields.
Cloning-based context-sensitive pointer alias analysis using binary decision diagrams (2004)

This paper presents the first scalable context-sensitive, inclusion-based pointer alias analysis for Java programs. Our approach to context sensitivity is to create a clone of a method for every context of interest, and run a context-insensitive algorithm over the expanded call graph to get context-sensitive results. For precision, we generate a clone for every acyclic path through a program's call graph, treating methods in a strongly connected component as a single node. Normally, this formulation is hopelessly intractable as a call graph often has 10 14 acyclic paths or more. We show that these exponential relations can be computed efficiently using binary decision diagrams (BDDs). Key to the scalability of the technique is a context numbering scheme that exposes the commonalities across contexts. We applied our algorithm to the most popular applications available on Sourceforge, and found that the largest programs, with hundreds of thousands of Java bytecodes, can be analyzed in under 20 minutes.This paper shows that pointer analysis, and many other queries and algorithms, can be described succinctly and declaratively using Datalog, a logic programming language. We have developed a system called bddbddb that automatically translates Datalog programs into highly efficient BDD implementations. We used this approach to develop a variety of context-sensitive algorithms including side effect analysis, type analysis, and escape analysis.
Spontaneous Reversal of the Developmental Aging of Normal Human Cells Following Transcriptional Reprogramming (2010)

Prematurely aged (shortened) telomeres appears to be a common feature of iPS cells created by current pluripotency protocols. However, the spontaneous appearance of lines that express sufficient telomerase activity to extend telomere length may allow the reversal of developmental aging in human cells for use in regenerative medicine.
The RNA-induced Silencing Complex: A Versatile Gene-silencing Machine (2009)

RNA interference is a powerful mechanism of gene silencing that underlies many aspects of eukaryotic biology. On the molecular level, RNA interference is mediated by a family of ribonucleoprotein complexes called RNA-induced silencing complexes (RISCs), which can be programmed to target virtually any nucleic acid sequence for silencing. The ability of RISC to locate target RNAs has been co-opted by evolution many times to generate a broad spectrum of gene-silencing pathways. Here, we review the fundamental biochemical and biophysical properties of RISC that facilitate gene targeting and describe the various mechanisms of gene silencing known to exploit RISC activity.
Odorants Presented to the Rat Nasal Cavity Increase Cortical Blood Flow (1999)

Complaints about unpleasant environmental odorants, both outdoor and indoor, are increasingly being reported. The main complaints of health symptoms from environmental odorants are eye, nose and throat irritation, headache and drowsiness. Complaints may arise from the stimulation of olfactory receptors or trigeminal chemoreceptors. Stimulation of cerebrovascular nociceptors originating from a branch of the trigeminal nerve may be associated with an increase in cortical blood flow which is thought to be related to headache. Since odorants are reported to elicit headaches, the possibility that odorants may increase cortical blood flow was examined. Cortical blood flow was monitored in rats using a laser-Doppler flowmeter. The flowmeter probe was placed over the left frontal cortex while propionic acid, cyclohexanone, amyl acetate or butanol was delivered to the nasal cavity via an olfactometer. Cortical blood flow increased as the concentration increased for three of the odorants tested. The greatest increase in blood flow occurred to the presentation of propionic acid, followed by cyclohexanone and amyl acetate. There was no response to butanol. These data demonstrate that odorants can alter cerebrovascular blood flow, which may account, in part, for one of the health symptoms reported for odorants.
Kinetics of free radical decay reactions in irradiated isotactic polypropylene (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of free radical decay reactions in irradiated isotactic polypropyleneN. Gvozdic, R. Basheer, Mahendra Mehta, and Malcolm DoleCite this: J. Phys. Chem. 1981, 85, 11, 1563–1569Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 May 1981https://pubs.acs.org/doi/10.1021/j150611a021https://doi.org/10.1021/j150611a021research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Resonant Frequency Characteristics of a SAW Device Attached to Resonating Micropillars (2012)

Recently we reported experimental and simulation results on an increase in resonance frequency of a SAW resonator caused by mass loading of micropillars made of SU-8, attached normal to the surface of the resonator. We concluded that SAW resonator and the SU-8 micropillars in unison form a system of coupled resonators. We have now extended this work and performed a finite element method simulation to study the resonance frequency characteristics of the SAW-based coupled resonator. In this paper we report the effect of the resonance frequency of the micropillars on the resonance frequency of the system of coupled resonators, and observe the coupling of micropillar resonance and the propagating SAW as described in the well known Dybwad system of coupled resonators.
Transformation and transposition of the genome of Mycobacterium marinum (2000)

Transposition and transformation efficiencies were comparable, suggesting that the limiting factor in transposition is the transformation step. Most of the experiments resulted in transposition of IS1096; however, better approaches are needed to improve transposition efficiency.
Clinical evaluation of rapid fluorescent diagnostic immunochromatographic test for influenza A virus (H1N1) (2018)

Rapid diagnostic tests (RDTs) have been developed to detect influenza A virus for the swift diagnosis and management of patients. However, despite the simplicity and convenience, the low sensitivity of RDTs remains a limitation for their use in point of care testing (POCT). In this study, we developed a rapid fluorescent immunochromatographic strip test (FICT) and the performance of FICT was confirmed by the real-time reverse transcription-polymerase chain reaction (rRT-PCR) of H1N1, compared with that of RDT. The limit of detection (LOD) of FICT was improved by 16-fold compared to RDT. FICT showed 85.29% sensitivity (29/34) (95% Confidence Interval [95% CI]: 68.94 to 95.05), 100% specificity (26/26) (95% CI: 86.78 to 100.00), and a strong correlation (kappa; 0. 92) compared with rRT-PCR (20 ≤ Ct ≤ 36). In contrast, RDT (Standard Diagnostics [SD] BIOLINE Influenza Ag A/ B/ A(H1N1) Pandemic) showed 55.88% sensitivity (19/34) (95% CI: 37.87 to 72.82), 100% specificity (26/26) (95% CI: 77.07 to 100), and had a fair correlation with rRT-PCR (kappa; 0. 75). FICT had better sensitivity than RDT (P < 0.01; McNemar's test). Therefore, FICT has the potential to improve the quality of current rapid POCT for the diagnosis of influenza A/H1N1 infection.
High Explosive Detonation and Electromagnetic Interaction (1979)

The effect of stationary, uniform, electric, and magnetic fields on steady-state detonation of condensed explosives is studied. The electrical conductivity profile in the region of the reaction zone provides a current path and Joule heating. Expected increases of detonation velocity and pressure by Joule heating are computed using an Abel equation of state. It is shown that the detonation pressure of TNT can be increased by as much as 12% and detonation velocity by as much as 6% before electrical breakdown can occur.
Morphologic and Functional Assessment of Coronary Artery Disease (2012)

HRP on CTA was an independent predictor of acute coronary events, as was stenosis (+) with SDS >0, and HRP had increased prognostic value over stenosis and abnormal MPI findings.
Pen and touch gestural environment for document editing on interactive tabletops (2013)

Combined pen and touch input is an interaction paradigm attracting increasing interest both in the research community and recently in industry. In this paper, we illustrate how pen and touch interaction techniques can be leveraged for editing and authoring of presentational documents on digital tabletops. Our system exploits the rich interactional vocabulary afforded by the simultaneous availability of the two modalities to provide gesture-driven document editing functionality as an expert alternative to widgets. For our bimanual gestures, we make use of non-dominant hand postures to set pen modes in which the dominant hand articulates a variety of transactions. We draw an analogy between such modifier postures and modifier keys on a keyboard to construct command shortcuts. Based on this model, we implement a number of common document editing operations, including several page and element manipulations, shape and text input with styling, clipart retrieval and insertion as well as undo/redo. The results of a lab study provide in-sights as to the strengths and limitations of our approach.
Novel Magnetic Properties of Graphene: Presence of Both Ferromagnetic and Antiferromagnetic Features and Other Aspects (2009)

Investigations of the magnetic properties of graphenes prepared by different methods reveal that dominant ferromagnetic interactions coexist along with antiferromagnetic interactions in all of the samples, somewhat like in frustrated or phase-separated systems. All of the graphene samples exhibit room-temperature magnetic hysteresis. The magnetic properties of the graphene samples depend on the number of layers and the sample area, small values of both favoring larger magnetization. Molecular charge-transfer affects the magnetic properties of graphene, interaction with a donor molecule such as tetrathiafulvalene having greater effect than with an electron-withdrawing molecule such as tetracyanoethylene.
Modeling, analysis and fabrication of a thrust vectoring spherical VTOL aerial vehicle (2014)

This paper aims at presenting a configuration for a multi-functional spherical aerial vehicle designed for search and rescue purposes which has the advantages of hover, level flight and amazing mobility. This is an advanced version of a Single-Copter and is called the Thrust Vectoring Aerial Craft (TVAC). The Spherical frame allows the vehicle to encounter an object without the risk of damaging the propeller and on board components and can land virtually anywhere without the need for critical pilot training The swash plate enabled thrust vectoring provides extra maneuverability and responsiveness to the craft in extreme environments. This first prototype consists of a single propeller, a 2-axis swash-plate and four control surfaces enclosed in a light-weight spherical frame. The craft is stabilized using a KK multicopter gyro based controller with four servo outputs and one motor output. A successful attitude control and stability is demonstrated with the swash-plate mechanism providing greater efficiency than its Single-Copter counterpart. Various experimental results after flight tests regarding the center of gravity and appropriate projected areas of various control vanes are also emphasized.
Combined chemical and mechanical effects on free radicals in UHMWPE joints during implantation (1991)

An electron spin resonance (ESR) technique is employed to determine the free radical distribution in the articulating surfaces of retrieved acetabular cups and knee-joint plateaus (retrieved after more than 6 years of implantation). Similar measurements made on samples prepared from cyclically stressed and unstressed cups, and on samples following oxidations in nitric acid and intralipid solutions provided sufficient data to gain more knowledge about the combined chemical and mechanical effects on PE free radicals during implantation. In UHMWPE free radicals are primarily initiated by gamma-ray sterilization; however, during implantation, peroxy (scission type) free radicals are formed and reach a maximum concentration level (equilibrium state) due to oxidation by chemical (hemoglobin and/or synovial fluids) environment of the joints. Subsequently, due to frictional heating and stress in the loading zones, free radical reaction is accelerated and their number is reduced only in those areas. This is consistent with the observations of a temperature rise in acetabular cups during in vitro frictional wear stress tests and in vivo telemetry observations, as reported by others. Compared with the previously reported SEM micrographs the low-free-radical regions are correlated with high-wear areas and the high-free-radical regions with the low-wear areas.