gebhart/patrepeval huggingface dataset:
Semiconductor Wires and Ribbons for High‐ Performance Flexible Electronics (2008)

This article reviews the properties, fabrication and assembly of inorganic semiconductor materials that can be used as active building blocks to form high-performance transistors and circuits for flexible and bendable large-area electronics. Obtaining high performance on low temperature polymeric substrates represents a technical challenge for macroelectronics. Therefore, the fabrication of high quality inorganic materials in the form of wires, ribbons, membranes, sheets, and bars formed by bottom-up and top-down approaches, and the assembly strategies used to deposit these thin films onto plastic substrates will be emphasized. Substantial progress has been made in creating inorganic semiconducting materials that are stretchable and bendable, and the description of the mechanics of these form factors will be presented, including circuits in three-dimensional layouts. Finally, future directions and promising areas of research will be described.
An electronegative inductive discharge instability (1996)

An instability has been observed with Langmuir probes in cylindrical inductive discharges operated with low electronegative gas pressures. The instability consists of ion density modulations that propagate axially and radially at the ion acoustic speed. Measurements and calculations of negative ion concentrations in oxygen discharges suggest that the radial distribution and the magnitude of the density drops are consistent with the negative ion population. The instability appears to be a periodic expulsion of most negative ions from the plasma core. The cause of the modulations remains to be clarified. The instability may provide valuable information on negative ion concentrations and temperatures in a low pressure regime where measurements of those parameters are difficult.
Identification and Classification of Conserved RNA Secondary Structures in the Human Genome (2006)

The discoveries of microRNAs and riboswitches, among others, have shown functional RNAs to be biologically more important and genomically more prevalent than previously anticipated. We have developed a general comparative genomics method based on phylogenetic stochastic context-free grammars for identifying functional RNAs encoded in the human genome and used it to survey an eight-way genome-wide alignment of the human, chimpanzee, mouse, rat, dog, chicken, zebra-fish, and puffer-fish genomes for deeply conserved functional RNAs. At a loose threshold for acceptance, this search resulted in a set of 48,479 candidate RNA structures. This screen finds a large number of known functional RNAs, including 195 miRNAs, 62 histone 3'UTR stem loops, and various types of known genetic recoding elements. Among the highest-scoring new predictions are 169 new miRNA candidates, as well as new candidate selenocysteine insertion sites, RNA editing hairpins, RNAs involved in transcript auto regulation, and many folds that form singletons or small functional RNA families of completely unknown function. While the rate of false positives in the overall set is difficult to estimate and is likely to be substantial, the results nevertheless provide evidence for many new human functional RNAs and present specific predictions to facilitate their further characterization.
Bis-(2,5-diphenylphospholanes) with sp2 Carbon Linkers:  Synthesis and Application in Asymmetric Hydrogenation (2007)

Four chiral diphosphine ligands consisting of bis(2,5-diphenylphospholan-1-yl) groups connected by the sp(2) carbon linkers 2,3-quinoxaline ((S,S)-Ph-Quinox), 2,3-pyrazine ((S,S)-Ph-Pyrazine), maleic anhydride ((S,S)-Ph-MalPhos), and 1,1'-ferrocene ((S,S)-Ph-5-Fc) were synthesized, and their cationic [rhodium(I)(COD)] complexes were prepared. These complexes were tested in asymmetric hydrogenation of functionalized olefins. [((S,S)-Ph-Quinox)Rh(COD)]BF4 showed high activity and selectivity against itaconate and dehydroamino acid substrates. The corresponding (S,S)-Ph-Pyrazine and (S,S)-Ph-MalPhos complexes exhibited lower activities and selectivities. [((S,S)-Ph-5-Fc)Rh(COD)]BF4 showed high activity with low selectivity for these substrates, but high activity and selectivity against 2-C-substituted cinnamate salts, whereas rhodium complexes of (S,S)-Ph-Quinox and (R,R)-Ph-BPE showed low activity and selectivity against 2-C-substituted cinnamate salts.
During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion (2005)

Independent studies have shown that CD27, 4-1BB, and OX40 can all promote survival of activated CD8+ T cells. We have therefore compared their impact on CD8+ memory T cell formation and responsiveness within one, physiologically relevant model system. Recombinant mice, selectively lacking input of one or two receptors, were challenged intranasally with influenza virus, and the immunodominant virus-specific CD8+ T cell response was quantified at priming and effector sites. Upon primary infection, CD27 and (to a lesser extent) 4-1BB made nonredundant contributions to accumulation of CD8+ virus-specific T cells in draining lymph nodes and lung, while OX40 had no effect. Interestingly though, in the memory response, accumulation of virus-specific CD8+ T cells in spleen and lung critically depended on all three receptor systems. This was explained by two observations: 1) CD27, 4-1BB, and OX40 were collectively responsible for generation of the same memory CD8+ T cell pool; 2) CD27, 4-1BB, and OX40 collectively determined the extent of secondary expansion, as shown by adoptive transfers with standardized numbers of memory cells. Surprisingly, wild-type CD8+ memory T cells expanded normally in primed OX40 ligand- or 4-1BB ligand-deficient mice. However, when wild-type memory cells were generated in OX40 ligand- or 4-1BB ligand-deficient mice, their secondary expansion was impaired. This provides the novel concept that stimulation of CD8+ T cells by OX40 and 4-1BB ligand during priming imprints into them the capacity for secondary expansion. Our data argue that ligand on dendritic cells and/or B cells may be critical for this.
A Novel Protein-Tyrosine Phosphatase Related to the Homotypically Adhering κ and μ Receptors (1997)

Here we describe a novel member of the receptor-like protein-tyrosine phosphatases (PTPs) termed PTP lambda, which is homologous to the homotypically adherent PTPs kappa and mu. Murine PTP lambda contains MAM, IgG, fibronectin type III, and dual phosphatase domains. As has been demonstrated for PTPs kappa and mu, PTP lambda mediates homotypic adhesion in vitro, and PTP lambda is associated with beta catenin in kidney epithelial cells. The extracellular domain of PTP lambda is proteolytically processed in cell culture as well as in vivo. Northern blot analysis reveals that PTP lambda is expressed throughout embryonic development and is predominately found in adult brain, lung, and kidney. In situ hybridization to 15.5-day old rat embryos reveals that PTP lambda is expressed in a variety of embryonic neuronal sites as well as in the esophagus, lung bronchiolar epithelium, kidney glomerular epithelium, olfactory epithelium, and various cartilagenous sites. Analysis of neonatal brain demonstrates expression in cells of the hippocampus, cortex, and the substantia nigra. Finally, immunohistochemical analysis reveals expression of this PTP on specific neurons of the spinal cord as well as on isolated cortical neurons.
Efficacy and Safety of Epratuzumab in Moderately to Severely Active Systemic Lupus Erythematosus: Results From Two Phase III Randomized, Double‐Blind, Placebo‐Controlled Trials (2016)

In patients with moderate or severely active SLE, treatment with epratuzumab + standard therapy did not result in improvements in response rates over that observed in the placebo + standard therapy group.
Differential Posttranscriptional Regulation of Androgen Receptor Gene Expression by Androgen in Prostate and Breast Cancer Cells* (1999)

Androgens, via the androgen receptor (AR), modulate the growth and proliferation of prostate and breast cancer cells. However, the molecular mechanisms underlying the regulation of AR gene expression by androgen in these cells remain to be fully elucidated. To explore differences in AR gene expression between these hormone-responsive tumor cell types, we studied androgen-responsive LNCaP prostate cancer and AR positive MDA453 breast cancer cells. Dihydrotestosterone (DHT) 10 nM increased LNCaP cell proliferation and the proportion of LNCaP cells in S-phase of the cell cycle but inhibited MDA453 cell proliferation and reduced the proportion of MDA453 cells in S-phase of cell cycle. In both these cell lines, DHT decreased total AR messenger RNA (mRNA) but increased AR protein. In LNCaP cells, DHT down-regulated AR mRNA transcription but stabilized AR mRNA. In contrast, in MDA453 cells, DHT had no effect on AR mRNA transcription but destabilized AR mRNA. In summary, transcriptional down-regulation induced by androgens in LNCaP cells results in down-regulation of steady-state AR mRNA despite an androgen-induced increase in AR mRNA stability. However, in MDA453 cells, posttranscriptional destabilization of AR mRNA appears to be the predominant mechanism resulting in down-regulation of AR mRNA by androgen. These results demonstrate cell-specific and divergent regulation of AR mRNA turnover by androgen and identify a novel pathway of androgen-induced posttranscriptional destabilization and down-regulation of AR mRNA in human breast cancer cells. Furthermore, these data establish an important role for posttranscriptional pathways in the regulation of AR gene expression by androgen in human prostate and breast cancer cells.
Proteomics: Recent Applications and New Technologies (2006)

Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models and man. In addition, several recent studies have attempted to integrate proteomics data with genomics and/or metabonomics data in a systems biology approach. The translation of proteomic technology and bioinformatics tools to clinical samples, such as in the areas of disease and toxicity biomarkers, represents one of the major opportunities and challenges facing this field. An ongoing challenge in proteomics continues to be the analysis of the serum proteome due to the vast number and complexity of proteins estimated to be present in this biofluid. Aside from the removal of the most abundant proteins, a number of interesting approaches have recently been suggested that may help reduce the overall complexity of serum analysis. In keeping with the increasing interest in applications of proteomics, the tools available for proteomic analyses continue to improve and expand. For example, enhanced tools (such as software and labeling procedures) continue to be developed for the analysis of 2D gels and protein quantification. In addition, activity-based probes are now being used to tag, enrich and isolate distinct sets of proteins based on enzymatic activity. One of the most active areas of development involves microarrays. Antibody-based microarrays have recently been released as commercial products while numerous additional capture agents (e.g. aptamers) and many additional types of microarrays are being explored.
Identification of Arsenite-resistance in Trypanosomes by Isozyme Characterization (1998)

Drug-resistance is one of the major problems ill the treatment of trypanosomiasis. If drug resistant str.uus could be identified car lice different combination of drugs could be used for better results. Arsenite containing drugs are still the most widely used drugs so far. This study intended to correlate arsenite-resistance with isozyme profiles in trypanosomes Tulahuen (TL) and Corpus Christi (CC) strains of T. cruzi. Trypanosoma conorhini isolated form Triatoma rubrofasciata in Taipei, as well as a chiropteran trypanosome isolated from Kenting were cultivated at 27°C and used for comparisons, Their survivals in different concentrations of sodium arsenite were monitored every 6-12 hours. The bat-trypanosomes were identified as arsenite-sensitive species since they died at low concentration while CC strain of T. cruzi was considered as an arsenite-resistanst strain as the trypanosomes survived even at a very high concentration. The electrophoretic morbilities of glucose-6-phosphatc dehydrogenase (G6PD) and phosphoglucose isomerase (PGI) isozymes were also compared. The results revealed as isozyme polymorphism in different strains T. cruzi and TL strain produced more than one isozyme bands in both isozyme cases. Similar PGI isozyme pattern was observed in T. conorhini and the bat-trypanosome, Uuiquely, there was not any isozyme bands of G6PD displayed by CC strain or T. cruzi. The correlation between arsenite-resistance and G6PD deficiency required more investigation and G6PD deficiency could be considered as all easier method for the identification of arsenite-resistance in trypanosomes.
Studies of Gastrointestinal Interactions (1975)

Johansson, C. Studies of gastrointestinal interactions. VII. Characteristics of the absorption pattern of sugar, fat, and protein from composite meals in man. A quantitative study. Scand. J. Gastroent. 1975, 10, 33-42.The absorption of sugar, fat, and protein after feeding two meals, differing in their content of glucose, was investigated in 7 healthy subjects, in double experiments with the multiple indicator dilution method. An average of 75% of the emptied amounts of sugar and 80% of the emptied fat and protein was absorbed during transit of the proximal 70 cm of the intestine. Differences in the absorption pattern between the meals were recorded, resulting from their different intragastric behaviour and gastric emptying pattern. Within the first hour significantly higher amounts of fat and protein were absorbed after the glucose-free than after the glucose-containing meal, whereas from the latter most of the glucose was absorbed early after ingestion. The absorptive capacity of the investigated segment was not exceeded for any component of the meals, owing to compensatory mechanisms by which the gastric emptying rate was inhibited and the transit time through the segment prolonged. The efficiency of sugar absorption was related to the transit time through the segment, in that a constant fraction was eliminated from the intestinal lumen per minute increase of the mean transit time. The net endogenous contribution of protein and fat at the exit of the segment amounted to an average of 3.0 g protein and 1.2 g fat during 3 hours.
Major Depressive Disorder Induced by Chronic Ketamine Abuse (2016)

Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.To the Editor: Ketamine, an NMDA (N-methyl-d-aspartate) glutamate antagonist, commonly used as an anesthetic agent, has emerged as a major substance of abuse particularly in Asia. Here, we present, to our knowledge, the first case of a patient who developed major depressive episodes after heavy and long-term ketamine use.Case report. Mr A, a 38-year-old man with no psychiatric family history, was admitted to the substance treatment ward for ketamine dependence.
Solid Dielectric Horn Antennas (1998)

Introduction. Fundamentals of Electromagnetic Waves. Dielectric Waveguide. Dielectric Sectoral and Pyramidal Horns. Dielectric Cylinder. Dielectric Cone. Dielectric Lenses.
Reaction of sulfur dioxide with limestone and the grain model (1976)

Abstract Experimental measurements of the reaction of sulfur dioxide and oxygen with limestones have demonstrated substantial influence of the geologic origin of the stone, its porosity and particle size, gaseous concentration of sulfur dioxide, and temperature on the course of reaction and the conversion (that is, the degree of utilization of the limestone content of the particles as a sorbent for sulfur dioxide). A mathematical model including intraparticle transport and chemical reaction within the particles (grain theory) has been developed to simulate this sulfur dioxide sorption reaction.
Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia (2003)

Lymphoid cells in most patients with chronic lymphocytic leukemia (CLL), when treated with rituximab, become CD20-. This is thought to be due to masking of CD20 by rituximab. We used specific antimouse immunoglobulin antibodies to detect rituximab on the surface of CLL lymphocytes and we demonstrate that rituximab is rarely detectable after therapy. Only 3 of 65 patients with CLL had rituximab detectable on their lymphocytes after rituximab therapy despite the fact that most had no detectable CD20 expression. In vitro mixing of CLL or Raji cells with rituximab demonstrated that rituximab was detectable on the surface of cells due to its binding to CD20. However, the addition of plasma led to the down-modulation of CD20 expression, and the rituximab became undetectable. This down-modulation of CD20 protein expression was associated with a down-modulation of CD20 mRNA. CLL cells that lost their CD20 expression regained CD20 expression after 24 hours in culture. These data suggest that rituximab therapy leads to a substantial but transient down-modulation of CD20 expression and that negativity for CD20 in cells from patients treated with rituximab is not necessarily due to CD20 masking. The importance of this down-modulation in the efficacy of current therapy with rituximab needs further investigation.
Targeting cyclophilin D and the mitochondrial permeability transition enhances β-cell survival and prevents diabetes in Pdx1 deficiency (2010)

Mutations of the pancreatic duodenal homeobox gene-1, Pdx1, cause heritable diabetes in humans and mice. A central abnormality with Pdx1 deficiency is increased death of beta-cells, leading to decreased beta-cell mass. We show that lentiviral suppression of Pdx1 increases death of mouse insulinoma MIN6 beta-cells associated with dissipation of the mitochondrial inner membrane electrochemical gradient, Deltapsi(m). Preventing mitochondrial permeability transition pore opening with the cyclophilin D inhibitor cyclosporin A restored Deltapsi(m) and rescued cell viability. Reduced beta-cell mass, markers of beta-cell apoptosis, necrosis, and decreased proliferation are present in Pdx1 haploinsufficient mice. Genetic ablation of the Ppif gene, encoding cyclophilin D, restored beta-cell mass and decreased TUNEL and complement complex labeling without affecting beta-cell proliferation. In adult mice maintained on a high-fat diet, Ppif ablation normalized fasting glucose and glucose and insulin responses to acute glucose challenge. Thus, cyclophilin D and the mitochondrial permeability transition are critical regulators of beta-cell death caused by Pdx1 insufficiency.
Substituted pyridazines as ligands in homoleptic (fac and mer) and heteroleptic Ru(ii) complexes (2011)

This article reports the preparation of a range of phenyl, pyridyl and pyrazinyl substituted pyridazines via the inverse electron demand [2 + 4] Diels-Alder reaction between 3,6-di(2-pyridyl)-1,2,4,5-tetrazines (bptz) and 3,6-di(2-pyrazinyl)-1,2,4,5-tetrazines (bpztz) and suitable dienophiles including acenaphthalene. The resulting polyaromatic compounds vary systematically in the number of aromatic substituents and the number and position of N-heteroatoms. For four of these compounds, the effect of the molecular changes on the solid-state structures were investigated using single crystal X-ray crystallography. The pyridazines were used as bidentate ligands in {M(II)(bipy)(2)} and tris(homoleptic) complexes (M = Fe, Ru). The optical and electrochemical properties of these complexes reflect the electron accepting character of the new ligands. The facial and meridional isomers of the tris complexes could be separated by column chromatography (on silica), thus allowing a spectral comparison of their absorption and emission properties. The solid-state structures of several of the metal complexes are discussed, including that of the facial isomer of the tris Ru(II) complex of 3,6-bis(2-pyridyl)-4,5-bis(4-pyridyl)pyridazine--a potential preformed geometric motif for the predirected construction of supramolecular assemblies.
Increased Power for the Analysis of Label-free LC-MS/MS Proteomics Data by Combining Spectral Counts and Peptide Peak Attributes (2010)

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics provides a wealth of information about proteins present in biological samples. In bottom-up LC-MS/MS-based proteomics, proteins are enzymatically digested into peptides prior to query by LC-MS/MS. Thus, the information directly available from the LC-MS/MS data is at the peptide level. If a protein-level analysis is desired, the peptide-level information must be rolled up into protein-level information. We propose a principal component analysis-based statistical method, ProPCA, for efficiently estimating relative protein abundance from bottom-up label-free LC-MS/MS data that incorporates both spectral count information and LC-MS peptide ion peak attributes, such as peak area, volume, or height. ProPCA may be used effectively with a variety of quantification platforms and is easily implemented. We show that ProPCA outperformed existing quantitative methods for peptide-protein roll-up, including spectral counting methods and other methods for combining LC-MS peptide peak attributes. The performance of ProPCA was validated using a data set derived from the LC-MS/MS analysis of a mixture of protein standards (the UPS2 proteomic dynamic range standard introduced by The Association of Biomolecular Resource Facilities Proteomics Standards Research Group in 2006). Finally, we applied ProPCA to a comparative LC-MS/MS analysis of digested total cell lysates prepared for LC-MS/MS analysis by alternative lysis methods and show that ProPCA identified more differentially abundant proteins than competing methods.
Addressing the Rare Word Problem in Neural Machine Translation (2014)

Neural Machine Translation (NMT) is a new approach to machine translation that has shown promising results that are comparable to traditional approaches. A significant weakness in conventional NMT systems is their inability to correctly translate very rare words: end-to-end NMTs tend to have relatively small vocabularies with a single unk symbol that represents every possible out-of-vocabulary (OOV) word. In this paper, we propose and implement an effective technique to address this problem. We train an NMT system on data that is augmented by the output of a word alignment algorithm, allowing the NMT system to emit, for each OOV word in the target sentence, the position of its corresponding word in the source sentence. This information is later utilized in a post-processing step that translates every OOV word using a dictionary. Our experiments on the WMT14 English to French translation task show that this method provides a substantial improvement of up to 2.8 BLEU points over an equivalent NMT system that does not use this technique. With 37.5 BLEU points, our NMT system is the first to surpass the best result achieved on a WMT14 contest task.