gebhart/patrepeval huggingface dataset:
Long-Term Temporal Convolutions for Action Recognition (2017)

Typical human actions last several seconds and exhibit characteristic spatio-temporal structure. Recent methods attempt to capture this structure and learn action representations with convolutional neural networks. Such representations, however, are typically learned at the level of a few video frames failing to model actions at their full temporal extent. In this work we learn video representations using neural networks with long-term temporal convolutions (LTC). We demonstrate that LTC-CNN models with increased temporal extents improve the accuracy of action recognition. We also study the impact of different low-level representations, such as raw values of video pixels and optical flow vector fields and demonstrate the importance of high-quality optical flow estimation for learning accurate action models. We report state-of-the-art results on two challenging benchmarks for human action recognition UCF101 (92.7%) and HMDB51 (67.2%).
Design and application of a lactulose biosensor (2017)

In this study the repressor of Escherichia coli lac operon, LacI, has been engineered for altered effector specificity. A LacI saturation mutagenesis library was subjected to Fluorescence Activated Cell Sorting (FACS) dual screening. Mutant LacI-L5 was selected and it is specifically induced by lactulose but not by other disaccharides tested (lactose, epilactose, maltose, sucrose, cellobiose and melibiose). LacI-L5 has been successfully used to construct a whole-cell lactulose biosensor which was then applied in directed evolution of cellobiose 2-epimerase (C2E) for elevated lactulose production. The mutant C2E enzyme with ~32-fold enhanced expression level was selected, demonstrating the high efficiency of the lactulose biosensor. LacI-L5 can also be used as a novel regulatory tool. This work explores the potential of engineering LacI for customized molecular biosensors which can be applied in practice.
Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats (2010)

We recently reported that a preponderance of small adipose cells, decreased expression of cell differentiation markers, and enhanced inflammatory activity in human subcutaneous whole adipose tissue were associated with insulin resistance. To test the hypothesis that small adipocytes exhibited these differential properties, we characterised small adipocytes from epididymal adipose tissue of Zucker Obese (ZO) and Lean (ZL) rats. Rat epididymal fat pads were removed and adipocytes isolated by collagenase digestion. Small adipocytes were separated by sequential filtration through nylon meshes. Adipocytes were fixed in osmium tetroxide for cell size distribution analysis via Beckman Coulter Multisizer. Quantitative real-time PCR for cell differentiation and inflammatory genes was performed. Small adipocytes represented a markedly greater percentage of the total adipocyte population in ZO than ZL rats (58±4% vs. 12±3%, p<0.001). In ZO rats, small as compared with total adipocytes had 4-fold decreased adiponectin, and 4-fold increased visfatin and IL-6 levels. Comparison of small adipocytes in ZO versus ZL rats revealed 3-fold decreased adiponectin and PPARγ levels, and 2.5-fold increased IL-6. In conclusion, ZO rat adipose tissue harbours a large proportion of small adipocytes that manifest impaired cell differentiation and pro-inflammatory activity, two mechanisms by which small adipocytes may contribute to insulin resistance.
Mercaptoammonium-Monolayer-Protected, Water-Soluble Gold, Silver, and Palladium Clusters (2000)

This paper describes gold, silver, and palladium nanoparticles coated with monolayers of trimethyl(mercaptoundecyl)ammonium ligands. The monolayer-protected clusters (MPCs) are synthesized in aqueous medium and are water soluble. In dry films, their highly charged surfaces inhibit the interdigitation of monolayer chains known (transmission electron microscopy) in dry films of alkanethiolate-coated nanoparticles. UV−vis spectra exhibit surface plasmon bands for Au and Ag MPCs at the expected wavelengths but none for Pd clusters. Thermogravimetric and transmission electron microscopy results suggest that Au and Ag nanoparticles readily aggregate through ionic association of the terminal ammonium groups but without metallic core fusion between particles. Two-component multilayers of MPCs can be affixed to surfaces by alternating exposure to anionic, mixed-monolayer hexanethiolate−mercaptoundecanoic acid MPCs and cationic Au ammonium-MPCs.
ChemInform Abstract: Studies in Spiroheterocycles. Part 28. Investigation of the Reaction of 3‐Aroylmethyleneindolin‐2‐ones with Thiosemicarbazide and Synthesis of Spiro(3H‐indole‐3,4′‐(3′H)‐pyrimidin)‐2(1H)‐ones. (1990)

Abstract N‐Methylindoline‐2,3‐dione (I) and the acetophenone (II) undergo addition reaction in the presence of a base to produce the 3‐hydroxyindolin‐2‐one (III) which is dehydrated upon treatment with conc.
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project (2017)

Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically defined phenotypes of the disease. Most of the clinical signs of DS are typical of the aging process including dysregulation of immune system. Beyond the causative genetic defect, DS persons display epigenetic alterations, particularly aberrant DNA methylation patterns that can contribute to the heterogeneity of the disease. In the present work, we investigated the levels of 5-hydroxymethylcytosine and of the Ten-eleven translocation dioxygenase enzymes, which are involved in DNA demethylation processes and are often deregulated in pathological conditions as well as in aging. Analyses were carried out on peripheral blood mononuclear cells of DS volunteers enrolled in the context of the MARK-AGE study, a large-scale cross-sectional population study with subjects representing the general population in eight European countries. We observed a decrease in 5-hydroxymethylcytosine, TET1, and other components of the DNA methylation/demethylation machinery in DS subjects, indicating that aberrant DNA methylation patterns in DS, which may have consequences on the transcriptional status of immune cells, may be due to a global disturbance of methylation control in DS.
Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is up-regulated in response to cell injury (1998)

Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins. Caveolin-1 and -2 show the widest range of expression, whereas caveolin-3 expression is restricted to muscle cell types. It has been previously reported that little or no caveolin mRNA species are detectable in the brain by Northern blot analyses or in neuroblastoma cell lines. However, it remains unknown whether caveolins are expressed within neuronal cells. Here we demonstrate the expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion (DRG) neurons by using mono-specific antibody probes. In PC12 cells, caveolin-1 expression is up-regulated on day 4 of nerve growth factor (NGF) treatment, whereas caveolin-2 expression is transiently up-regulated early in the differentiation program and then rapidly down-regulated. Interestingly, caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins.
Optimal particle size for beta 2 agonist and anticholinergic aerosols in patients with severe airflow obstruction. (1996)

BACKGROUND: The optimal particle size of a beta 2 agonist or anticholinergic aerosol in patients with severe airflow obstruction is unknown. METHODS: Seven stable patients with a mean forced expiratory volume in one second (FEV1) of 37.9% of the predicted value inhaled three types of monodisperse salbutamol and ipratropium bromide aerosols with particle sizes of 1.5 microns, 2.8 microns, and 5 microns, respectively, and a placebo aerosol. The volunteers inhaled 20 micrograms salbutamol and 8 micrograms ipratropium bromide, after which lung function changes were determined and analysed with repeated measurements analysis of variance (ANOVA). RESULTS: Greater improvements in FEV1, specific airway conductance (sGaw) and maximum expiratory flow at 75%/50% of the forced vital capacity (MEF75/50) were induced by the 2.8 microns aerosol than by the other particle sizes. CONCLUSIONS: In patients with severe airflow obstruction the particle size of choice for a beta 2 agonist or anticholinergic aerosol should be approximately 3 microns.
Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody (2006)

This study was the first to show that FLI-1 can be seen in a variety of solid tumours, some of which had never been explored before. This finding should be kept in mind, especially when using FLI-1 as a marker for finding the primary origin of poorly differentiated metastatic tumour. Finally, despite the expression of FLI-1 in numerous malignancies, it is still considered to be highly sensitive and specific in distinguishing EWS/PNET from other tumour types in general and from other SRCTs in particular.
Sorafenib (2006)

Sorafenib is a small molecule inhibitor of several kinases involved in tumour proliferation and tumour angiogenesis including Raf, VEGFR and platelet derived growth factor receptor. In vivo Raf kinase inhibition has been observed in pharmacodynamic studies. Sorafenib is one of several VEGF-targeting compounds with recently demonstrated substantial anti-tumour effects in metastatic renal cell carcinoma. Delay in time to disease progression has been demonstrated in cytokine-refractory metastatic renal cell carcinoma, and further investigation is ongoing in a wide variety of tumour types. Sorafenib is well tolerated, with common toxicities including rash, diarrhoea, hand-foot skin reaction, fatigue and hypertension, when administered as the standard dose of 400 mg b.i.d.
Anal cancer in Alaska; a retrospective study of incidence, treatment, and outcomes. (2003)

Anal cancer is a rare tumor usually of squamous histology that is managed most often with concurrent chemotherapy and radiation therapy. Surgery is commonly reserved for those who fail primary treatment. We conducted a retrospective analysis of the medical records of patients with anal cancer seen in two radiation therapy centers in Alaska from the period of 1996 to mid-2001. Records were reviewed for diagnosis, sex, age, staging, treatment and outcomes. Twenty-four patients were identified with squamous cell carcinoma of the anus. Average age at diagnosis was 53. Tumor size was predominantly 2-5 centimeters. Four patients had nodal involvement and three had distant metastasis. Twenty patients received radiation. Nineteen received flourouracil and either cisplatin or mitomycin. Three patients underwent abdominoperineal resections. Ten were found to have no evidence of disease at an average of twenty-two months. These results are consistent with findings of larger studies elsewhere.
Efficacy of a constantly adaptive language modeling technique for web-scale applications (2009)

In this paper, we describe CALM, a method for building statistical language models for the Web. CALM addresses several unique challenges dealing with the Web contents. First, CALM does not rely on the whole corpus to be available to build the language model. Instead, we design CALM to progressively adapt itself as Web chunks are made available by the crawler. Second, given the dynamic and dramatic changes in the Web contents, CALM is designed to quickly enrich its lexicon and N-grams as new vocabulary and phrases are discovered. To reduce the amount of heuristics and human interventions typically needed for model adaptation, we derive an information theoretical formula for CALM to facilitate the optimal adaptation in the maximum a posteriori (MAP) sense. Testing against a collection of Web chunks where new vocabulary and phrases are dominant, we show CALM can achieve comparable and satisfactory model measured in perplexity. We also show CALM is robust against over training and the initial condition, suggesting that any assumptions made in obtaining the initial model can gradually see their impacts diminished as CALM runs its full course and adapt to more data.
Pure Exploration of Multi-armed Bandit Under Matroid Constraints (2016)

We study the pure exploration problem subject to a matroid constraint (Best-Basis) in a stochastic multi-armed bandit game. In a Best-Basis instance, we are given $n$ stochastic arms with unknown reward distributions, as well as a matroid $\mathcal{M}$ over the arms. Let the weight of an arm be the mean of its reward distribution. Our goal is to identify a basis of $\mathcal{M}$ with the maximum total weight, using as few samples as possible. The problem is a significant generalization of the best arm identification problem and the top-$k$ arm identification problem, which have attracted significant attentions in recent years. We study both the exact and PAC versions of Best-Basis, and provide algorithms with nearly-optimal sample complexities for these versions. Our results generalize and/or improve on several previous results for the top-$k$ arm identification problem and the combinatorial pure exploration problem when the combinatorial constraint is a matroid.
Approximate intrinsic bias in estimates of heritability based on variance component analysis (1980)

Journal Article Approximate intrinsic bias in estimates of heritability based on variance component analysis Get access M. GROSSMAN, M. GROSSMAN Department of Dairy Science and the Department of Animal Science, University of Illinois at Urbana-ChampaignUrbana, IL 61801 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. W. NORTON H. W. NORTON Department of Dairy Science and the Department of Animal Science, University of Illinois at Urbana-ChampaignUrbana, IL 61801 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 71, Issue 4, July 1980, Pages 295–297, https://doi.org/10.1093/oxfordjournals.jhered.a109371 Published: 01 July 1980
CO2 Reduction at Low Overpotential on Cu Electrodes Resulting from the Reduction of Thick Cu2O Films (2012)

Modified Cu electrodes were prepared by annealing Cu foil in air and electrochemically reducing the resulting Cu(2)O layers. The CO(2) reduction activities of these electrodes exhibited a strong dependence on the initial thickness of the Cu(2)O layer. Thin Cu(2)O layers formed by annealing at 130 °C resulted in electrodes whose activities were indistinguishable from those of polycrystalline Cu. In contrast, Cu(2)O layers formed at 500 °C that were ≥~3 μm thick resulted in electrodes that exhibited large roughness factors and required 0.5 V less overpotential than polycrystalline Cu to reduce CO(2) at a higher rate than H(2)O. The combination of these features resulted in CO(2) reduction geometric current densities >1 mA/cm(2) at overpotentials <0.4 V, a higher level of activity than all previously reported metal electrodes evaluated under comparable conditions. Moreover, the activity of the modified electrodes was stable over the course of several hours, whereas a polycrystalline Cu electrode exhibited deactivation within 1 h under identical conditions. The electrodes described here may be particularly useful for elucidating the structural properties of Cu that determine the distribution between CO(2) and H(2)O reduction and provide a promising lead for the development of practical catalysts for electrolytic fuel synthesis.
Risk-sharing, adjustment, and trade (1994)

We consider a dynamic model of labor mobility in a small open economy with stochastic terms of trade. Migration is costly and markets for labor income risk are absent. Risk-aversion slows down the movement of the most productive workers into the risky sector, and speeds up that of the least productive ones. The effect of tariffs and autarky on risk-bearing is examined. A given policy may improve social welfare for some initial conditions and lower it for others. Thus policy design for such an economy is context-specific and can be time-inconsistent.
Sodium Influx Plays a Major Role in the Membrane Depolarization Induced by Oxygen and Glucose Deprivation in Rat Striatal Spiny Neurons (1999)

Our findings show that, although the ischemia-induced membrane depolarization is coupled with a rise of [Na+]i and [Ca2+]i, only the Na+ influx plays a prominent role in this early electrophysiological event, whereas the increase of [Ca2+]i might be relevant for the delayed neuronal death. We also suggest that the activation of ATP-dependent K+ channels might counteract the ischemia-induced membrane depolarization.
Expanded concept of the adiabatic population transfer using dressed states (1999)

We investigate several configurations for complete population transfer on the basis of the dressed state picture in a three-level system. This picture allows us not only to confirm an atom staying in the only dark state all the time under the well-known stimulated Raman adiabatic passage but also to find the considerably different dynamics from the conventional adiabatic process in cases where the pulses are significantly overlapped or concurrent (optimal detuning method). We expand the concept of the adiabatic process in order to explain all these cases.
B-lymphocyte depletion therapy in rheumatoid arthritis and other autoimmune disorders (2002)

B-lymphocyte depletion therapy is being explored in a wide range of autoimmune disorders. In many, there is early evidence for efficacy, and immunosuppression has not been a major problem. The mechanism of action is unclear, but appears to be consistent with the lowering of autoantibody levels, where relevant antibodies are quantifiable. An interesting finding is the persistence of clinical improvement for periods of 1 year or more after B-lymphocyte return, which supports the concept that stochastic generation of rare pathogenic B-lymphocyte subsets may be a rate-limiting step in pathogenesis.
Erythropoietic protoporphyria (2009)

Erythropoietic protoporphyria (EPP) is an inherited disorder of the haem metabolic pathway characterised by accumulation of protoporphyrin in blood, erythrocytes and tissues, and cutaneous manifestations of photosensitivity. EPP has been reported worldwide, with prevalence between 1:75,000 and 1:200,000. It usually manifests in early infancy upon the first sun exposures. EPP is characterised by cutaneous manifestations of acute painful photosensitivity with erythema and oedema, sometimes with petechiae, together with stinging and burning sensations upon exposure to sunlight, without blisters. These episodes have a variable severity depending on the exposure duration and may result in chronic permanent lesions on exposed skin. As protoporphyrin is a lipophilic molecule that is excreted by the liver, EPP patients are at risk of cholelithiasis with obstructive episodes, and chronic liver disease that might evolve to rapid acute liver failure. In most patients, EPP results from a partial deficiency of the last enzyme of the haem biosynthetic pathway, ferrochelatase, EC 4.99.1.1/FECH (encoded by the FECH gene). EPP appears to be inherited as an autosomal dominant disease, the clinical expression of which is modulated by the presence of the hypomorphic FECH IVS3-48C allele trans, but recessive inheritance with two mutated FECH alleles has also been described. In about 2% of patients, overt disease was recently shown to be caused by gain-of-function mutations in the erythroid-specific aminolevulinic acid synthase 2 (ALAS2/ALAS, EC 2.3.1.27) gene and named X-linked dominant protoporphyria. Diagnosis is established by finding increased levels of protoporphyrin in plasma and red blood cells, and detection of a plasma fluorescence peak at 634 nm. Investigations for hepatic involvement, ferrochelatase activity level, genetic analysis (FECH mutations, presence of the hypomorphic FECH IVS3-48C allele trans and ALAS2 mutations) and family studies are advisable. Differential diagnosis includes phototoxic drug reactions, hydroa vacciniforme, solar urticaria, contact dermatitis, angio-oedema and, in some cases, other types of porphyria. Management includes avoidance of exposure to light, reduction of protoporphyrin levels and prevention of progression of possible liver disease to liver failure. As the major risk in EPP patients is liver disease, a regular follow-up of hepatic involvement is essential. Sequential hepatic and bone marrow transplantation should be considered as a suitable treatment for most severe cases of EPP with hepatic involvement. EPP is a lifelong disorder whose prognosis depends on the evolution of the hepatic disease. However, photosensitivity may have a significant impact on quality of life of EPP patients.
Adhesion Molecules Involved in Transendothelial Migration of Human Hematopoietic Progenitor Cells (2000)

In the process of homing, CD34(+) hematopoietic progenitor cells migrate across the bone marrow endothelium in response to stromal cell-derived factor (SDF)-1. To develop more efficient stem cell transplantation procedures, it is important to define the adhesion molecules involved in the homing process. Here, we identified the adhesion molecules that control the migration of primary human CD34(+) cells across human bone marrow endothelial cells. Migration of CD34(+) cells is enhanced across interleukin 1beta prestimulated bone marrow endothelium, suggesting an important role for the endothelium in adhesion and formation of the chemotactic gradient. Under these conditions, 30-100 ng/ml SDF-1 induced a rapid and efficient migration of CD34(+) cells (+/- 46% migration in 4 h). In contrast, 600-1,000 ng/ml SDF-1 were required for optimal migration across fibronectin-coated filters. Subsequent studies revealed that transendothelial migration of CD34(+) cells is mediated by beta1- and beta2-integrins and PECAM-1 (CD31) but not by CD34 or E-selectin. Whereas these antibodies individually blocked migration for 25%-35%, migration was reduced by 68% when the antibodies were combined. Thus, these adhesion molecules play specific and independent roles in the transmigration process. Finally, O-glycosylated proteins appeared to play a role, since SDF-1-induced migration of CD34(+) cells (treated with a glycoprotease from Pasteurella haemolytica) across endothelial cells was clearly inhibited. In conclusion, we show that efficient SDF-1-induced migration of primary human CD34(+) cells across bone marrow endothelium is mediated by beta1-integrins, beta2-integrins, CD31 and O-glycosylated proteins.