gebhart/patrepeval huggingface dataset:
Robust pole placement stabilizer design using linear matrix inequalities (2000)

This paper presents the design of robust power system stabilizers which place the system poles in an acceptable region in the complex plane for a given set of operating and system conditions. It therefore, guarantees a well damped system response over the entire set of operating conditions, The proposed controller uses full state feedback. The feedback gain matrix is obtained as the solution of a linear matrix inequality expressing the pole region constraints for polytopic plants. The technique is illustrated with applications to the design of stabilizers for a single machine and a 9 bus, 3 machine power system.
Research on an Anti-Perturbation Kalman Filter Algorithm (2011)

Abstract. An improved Kalman filter algorithm is proposed by two kinds of anti-perturbation method which is derived according to the perturbation theorem of inverse matrix. Furthermore, direction-correcting has been merged into the algorithm by using multiple hypothesis testing theory which can detect the current direction of a target. Finally, Both quantitative and qualitative analysis are given in detail. The measurements and experiments based on indoor positioning demonstrate that the improved algorithm(named IKF) has great performance.
VAXcluster (1986)

A VAXcluster is a highly available and extensible configuration of VAX computers that operate as a single system. To achieve performance in a multicomputer environment, a new communications architecture, communications hardware, and distributed software were jointly designed. The software is a distributed version of the VAX/VMS operating system that uses a distributed lock manager to synchronize access to shared resources. The communications hardware includes a 70 megabit per second message-oriented interconnect and an interconnect port that performs communications tasks traditionally handled by software. Performance measurements show this structure to be highly efficient, for example, capable of sending and receiving 3000 messages per second on a VAX-11/780.
The Frequency of Familial Dilated Cardiomyopathy in a Series of Patients with Idiopathic Dilated Cardiomyopathy (1992)

Dilated cardiomyopathy was found to be familial in at least one in five of the patients in this study, a considerably higher percentage than in previous reports. This finding has important implications for family screening and provides direction for further investigation into the causes and natural history of dilated cardiomyopathy.
The DVB Terrestrial (DVB-T) specification and its implementation in a practical modem (1996)

Key features of the DVB-T specification for digital terrestrial television, jointly agreed in 1996 by broadcasters and manufacturers, are described. The DVB-T builds on the work of several European collaborative projects and uses COFDM to counter the peculiarities of the terrestrial channel. Some issues affecting the receiver cost and feasibility are explained, including details of the effects of local-oscillator phase noise. An experimental modem, built by BBC R&D and used to make the first-ever successful demonstration of DVB-T-compliant transmissions, is outlined.
A mouse model of human adaptive immune functions: HLA‐A2.1‐/HLA‐DR1‐transgenic H‐2 class I‐/class II‐knockout mice (2004)

HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice were created and their immunological potential evaluated in response to hepatitis B DNA vaccine. Every single immunized mouse developed hepatitis B virus-specific antibodies, HLA-DR1-restricted helper, and HLA-A2.1-restricted cytolytic T cell responses directed at the same immunodominant epitopes as those identified in naturally infected or vaccinated humans. These mice were specifically protected against a hepatitis B-recombinant vaccinia virus infection with a 10,000-fold or more reduction of the virus load at day 4 post-challenge. These mice represent a unique in vivo experimental model for human immune function studies without any interference with mouse MHC response which dwarfed the prediction of human responses. Furthermore, they enable the complete monitoring of immune adaptative responses for preclinical screening of candidate vaccines.
K<sup>+</sup> Cycling and Its Regulation in the Cochlea and the Vestibular Labyrinth (2002)

Potassium (K(+)) plays a very important role in the cochlea. K(+) is the major cation in endolymph and the charge carrier for sensory transduction and the generation of the endocochlear potential. The importance of K(+) handling in the cochlea is marked by the discovery of several forms of hereditary deafness that are due to mutations of K(+) channels. Deafness results from mutations of KCNQ4, a K(+) channel in the sensory hair cells, as well as from mutations of the gap junction proteins GJB2, GJB3 and GJB6 that may facilitate cell-to-cell movements of K(+). Deafness results also from mutations of KCNQ1 or KCNE1, subunits of a K(+) channel that carries K(+) from strial marginal cells and vestibular dark cells into endolymph. Further, deafness results from mutations of KCNJ10, a K(+) channel that generates the endocochlear potential in conjunction with the high K(+) concentration in strial intermediate cells and the low K(+) concentration in the intrastrial fluid spaces. This review details recent advances in the understanding of K(+) transport and its regulation in the cochlea and the vestibular labyrinth.
Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice (2011)

Cluster of differentiation 69 (CD69) has been identified as a lymphocyte early activation marker, and recent studies have indicated that CD69 mediates intracellular signals and plays an important role in various inflammatory diseases. Cigarette smoke (CS) is a strong proinflammatory stimulus that induces the release of proinflammatory mediators by recruiting macrophages and neutrophils into the lung tissue, and is one of the main risk factors for a number of chronic diseases. However, the potential role of CD69 in CS-induced pulmonary inflammation has not been determined. To address to this question, CD69-deficient (KO) and wild-type (WT) mice were subjected to CS-induced acute pulmonary inflammation. After the exposure with CS, the expression of CD69 in the lung of WT mice was significantly induced, it was predominantly observed in macrophages. In conjunction with this phenomenon, neutrophil and macrophage cell counts, and expression of several cytokines were significantly higher in the bronchoalveolar lavage fluid (BALF) of CS-exposed WT mice compared with air-exposed WT mice. Likewise, the CS-induced accumulation of inflammatory cells and cytokines expression were significantly lower in CD69-KO mice than in WT mice. These results suggest that CD69 on macrophages is involved in CS-induced acute pulmonary inflammation.
Data Fusion for Robotic Assembly Tasks Based on Human Skills (2004)

This work describes a data fusion architecture for robotic assembly tasks based on human sensory-motor skills. These skills are transferred to the robot through geometric and dynamic perception signals. Artificial neural networks are used in the learning process. The data fusion paradigm is addressed. It consists of two independent modules for optimal fusion and filtering. Kalman techniques linked to stochastic signal evolutions are used in the fusion algorithm. Compliant motion signals obtained from vision and pose sense are fused, enhancing the task performance. Simulations and peg-in-hole experiments are reported.
Road Traffic Noise and Incident Myocardial Infarction: A Prospective Cohort Study (2012)

Exposure to long-term residential road traffic noise was associated with a higher risk for MI, in a dose-dependent manner.
Turnover rents – the norm rather than the exception? (1991)

Looks at the use of turnover rents as a solution for both retailers and developers in the light of the current retail market to consider whether turnover rents will become more widely adopted. Examines turnover rent from the retailers′ viewpoint and the developers′ viewpoint, as well as the marketing of schemes. Concludes that although there are some negative aspects to turnover rent, they represent a move towards common interest between retailers and developers.
Chimeric Bovine/Human Parainfluenza Virus Type 3 Expressing Respiratory Syncytial Virus (RSV) F Glycoprotein: Effect of Insert Position on Expression, Replication, Immunogenicity, Stability, and Protection against RSV Infection (2014)

The research findings presented here will be instrumental for improving the design of a bivalent pediatric vaccine for respiratory syncytial virus and parainfluenza virus type 3, two major causes of severe respiratory tract infection in infants and young children. Moreover, this knowledge has general application to the development and clinical evaluation of other mononegavirus vectors and vaccines.
FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA (2012)

Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA). The SMN complex localizes in both the cytoplasm and nuclear Gems, and loss of Gems is a cellular hallmark of fibroblasts in patients with SMA. Here, we report that FUS associates with the SMN complex, mediated by U1 snRNP and by direct interactions between FUS and SMN. Functionally, we show that FUS is required for Gem formation in HeLa cells, and expression of FUS containing a severe ALS-causing mutation (R495X) also results in Gem loss. Strikingly, a reduction in Gems is observed in ALS patient fibroblasts expressing either mutant FUS or TDP-43, another ALS-causing protein that interacts with FUS. The physical and functional interactions among SMN, FUS, TDP-43, and Gems indicate that ALS and SMA share a biochemical pathway, providing strong support for the view that these motor neuron diseases are related.
Development of antibody-based c-Met inhibitors for targeted cancer therapy (2015)

Signaling pathways mediated by receptor tyrosine kinases (RTKs) and their ligands play important roles in the development and progression of human cancers, which makes RTK-mediated signaling pathways promising therapeutic targets in the treatment of cancer. Compared with small-molecule compounds, antibody-based therapeutics can more specifically recognize and bind to ligands and RTKs. Several antibody inhibitors of RTK-mediated signaling pathways, such as human epidermal growth factor receptor 2, vascular endothelial growth factor, epidermal growth factor receptor or vascular endothelial growth factor receptor 2, have been developed and are widely used to treat cancer patients. However, since the therapeutic options are still limited in terms of therapeutic efficacy and types of cancers that can be treated, efforts are being made to identify and evaluate novel RTK-mediated signaling pathways as targets for more efficacious cancer treatment. The hepatocyte growth factor/c-Met signaling pathway has come into the spotlight as a promising target for development of potent cancer therapeutic agents. Multiple antibody-based therapeutics targeting hepatocyte growth factor or c-Met are currently in preclinical or clinical development. This review focuses on the development of inhibitors of the hepatocyte growth factor/c-Met signaling pathway for cancer treatment, including critical issues in clinical development and future perspectives for antibody-based therapeutics.
Efficient Synthesis of Narrowly Dispersed Brush Copolymers and Study of Their Assemblies: The Importance of Side Chain Arrangement (2009)

Efficient, one-pot preparation of synthetically challenging, high molecular weight (MW), narrowly dispersed brush block copolymers and random copolymers in high conversions was achieved by ring-opening metathesis (co)polymerization (ROMP) of various macromonomers (MMs) using the highly active, fast-initiating ruthenium olefin metathesis catalyst (H(2)IMes)(pyr)(2)(Cl)(2)RuCHPh. A series of random and block copolymers were prepared from a pair of MMs containing polylactide (PLA) and poly(n-butyl acrylate) (PnBA) side chains at similar MWs. Their self-assembly in the melt state was studied by small-angle X-ray scattering (SAXS) and atomic force microscopy (AFM). In brush random copolymers containing approximately equal volume fractions of PLA and PnBA, the side chains segregate into lamellae with domain spacing of 14 nm as measured by SAXS, which was in good agreement with the lamellar thickness measured by AFM. The domain spacings and order-disorder transition temperatures of brush random copolymers were insensitive to the backbone length. In contrast, brush block copolymers containing approximately equal volume fractions of these MMs self-assembled into highly ordered lamellae with domain spacing over 100 nm. Their assemblies suggested that the brush block copolymer backbone adopted an extended conformation in the ordered state.
Patient entries in the electronic medical record: an interactive interview used in primary care. (1995)

We describe the development, implementation, and use of a computer-administered patient interview, the Health History Interview, by over 300 new patients in a primary care practice at Boston's Beth Israel Hospital. The interview has been well accepted by patients and rated positively by providers. It electronically captures clinical information directly from patients for use during their initial encounter with a provider. It facilitates aggregate analysis of clinical data for quality improvement efforts, such as aiming preventive medicine interventions at identified problem areas within the clinic. Expectations management has been an important task throughout the project. Increasing use of the interview beyond the 30-40% of new patients who have taken it will require greater communication with patients, greater convenience to patients and providers, and more evidence of the clinical, administrative, and research benefits of the technique. Most important, full implementation will require fundamental changes in physician practice habits and patterns of communication between patients and the health care system, as well as clearly demonstrated cost-benefit improvements through the use of these tools.
Measurements of ground-state OH rotational energy-transfer rates (1999)

We have studied rotational energy transfer (RET) in collisions of OH with the bath gases Ar, N2, O2, and H2O at 293 K. Rotationally hot OH(X 2Π3/2, v″=0, N″=1–12) was generated by photolysis of H2O2 at 266 nm, and collisional relaxation of the nascent rotational distribution was monitored by laser-induced fluorescence. The data are remarkably well described by an exponential-gap model for the matrix of state-to-state RET rate constants. For Ar, N2, and O2, RET rates are significantly faster at low N″ than high N″; for H2O, RET is approximately an order of magnitude faster than for the other bath gases, and the rate is not as strongly dependent on N″. The rates of rotationally inelastic energy transfer are similar in the X and A states, but the X-state depopulation rate constants (including nearly elastic, Λ-doublet-changing collisions) are faster than the A-state values. By comparing the depopulation rates derived from the present experiment with previous linewidth measurements, we conclude that RET is the dominant source of pressure broadening for OH microwave transitions and makes a significant contribution for ultraviolet A–X transitions. While generally good agreement is found between the present results and previous OH RET studies for both the ground and excited electronic states, some significant discrepancies are noted.
Variable oxygen exposure causes preretinal neovascularization in the newborn rat. (1993)

Consistency of oxygen therapy is more important than overall oxygen level in inducing retinopathy. Consideration should be given to tighter control of intended oxygen therapy in premature infants, regardless of the target saturation level.
Kinmoonosides A−C, Three New Cytotoxic Saponins from the Fruits of Acacia concinna, a Medicinal Plant Collected in Myanmar (2000)

Three genuine saponins, named kinmoonosides A-C (1-3), have been isolated, together with a new monoterpenoid (4), from a methanolic extract of the fruits of Acacia concinna. The structures of kinmoonosides A-C were elucidated on the basis of spectral analysis as 3-O-¿alpha-L-arabinopyranosyl(1-->6)-[beta-D-glucopyranosyl(1-->2) ]-b eta-D-glucopyranosyl¿-21-O-¿(6R, 2E)-2-hydroxymethyl-6-methyl-6-O-[4-O-(2'E)-6'-hydroxyl-2'-hydroxymet hyl-6'-methyl-2',7'-octadienoyl-beta-D-quinovopyranosyl]-2, 7-octadienoyl¿acacic acid 28-O-alpha-L-arabinofuranosyl(1-->4)-[beta-D-glucopyranosyl(1-->3)]-a lpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl ester (1); 3-O-¿alpha-L-arabinopyranosyl(1-->6)-[beta-D-glucopyranosyl(1-->2) ]-b eta-D-glucopyranosyl¿-21-O-¿(6S, 2E)-2-hydroxymethyl-6-methyl-6-O-[4-O-(2'E)-6'-hydroxyl-2'-hydroxymet hyl-6'-methyl-2',7'-octadienoyl-beta-D-quinobopyranosyl]-2, 7-octadienoyl¿acacic acid 28-O-alpha-L-arabinofuranosyl(1-->4)-[beta-D-glucopyranosyl(1-->3)]-a lpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl ester (2); and 3-O-¿alpha-L-arabinopyranosyl(1-->6)-[beta-D-glucopyranosyl(1-->2) ]-b eta-D-glucopyranosyl¿-21-O-[(2E)-6-hydroxyl-2-hydroxymethyl-6-methyl- 2,7-octadienoyl]acacic acid 28-O-alpha-L-arabinofuranosyl(1-->4)-[beta-D-glucopyranosyl(1-->3)]-a lpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl ester (3), respectively. The new monoterpenoid 4 was determined as 4-O-[(2E)-6-hydroxyl-2-hydroxymethyl-6-methyl-2, 7-octadienoyl]-D-quinovopyranose. Compounds 1-3 showed significant cytotoxicity against human HT-1080 fibrosarcoma cells.
Unusually Stable, Versatile, and Pure Arenediazonium Tosylates: Their Preparation, Structures, and Synthetic Applicability (2008)

A new, simple, and effective method for the diazotization of a wide range of arylamines has been developed by using a polymer-supported diazotization agent in the presence of p-toluenesulfonic acid. Various pure arenediazonium tosylates with unusual stabilities can be easily prepared by this method. As a result, these salts are useful and versatile substrates for subsequent transformations, such as halogenation and Heck-type reactions. The unusual stabilities of arenediazonium tosylates are also preliminarily discussed with their X-ray structures.
Complete amino acid sequence of luffin-a, a ribosome-inactivating protein from the seeds of Luffa cylindrica. (1990)

Luffin is a ribosome-inacivating protein (RIP) present in the seeds of the sponge gourd (Luffa cylindrica) that inactivates eucaryotic ribosomes by cleaving the TV-glycosidic bond of A4324 of 28S rRNA, inhibiting protein biosynthesis.1} When assayed using rabbit re-
CD40-mediated signals inhibit the binding of TNF receptor-associated factor 2 to the CD40 cytoplasmic domain (1997)

TNF receptor-associated factor 2 (TRAF2) is a signal-transducing protein associated with the CD40 cytoplasmic domain. It has been hypothesized that during signal transduction, TRAF2 must be released from CD40 in order for it to interact with downstream signaling molecules. We found that CD40 and TRAF2 were constitutively associated with each other in a human B cell line. Following stimulation with an anti-CD40 Ab, a decrease in the amount of CD40-associated TRAF2 was observed that could not be explained by a change in total level of either of the proteins. These results, as well as similar findings obtained with 293 cells overexpressing CD40 and TRAF2, suggested that CD40-mediated signals inhibited the CD40-TRAF2 interaction. We then conducted binding studies using CD40 cytoplasmic domain fusion proteins and TRAF2 derived from either control or CD40-stimulated cell lines. These in vitro studies also indicated that the binding of TRAF2 to the CD40 cytoplasmic domain was inhibited by CD40 stimulation. The results of these experiments, as well as differences between the in vitro and in vivo findings, indicated that multiple mechanisms were involved in the inhibition of the CD40-TRAF2 interaction by CD40 signals. Possible mechanisms of inhibition are discussed based on mapping of the TRAF2 binding site on the CD40 cytoplasmic domain.
Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges (2006)

Potential applications of tissue engineering in regenerative medicine range from structural tissues to organs with complex function. This review focuses on the engineering of heart valve tissue, a goal which involves a unique combination of biological, engineering, and technological hurdles. We emphasize basic concepts, approaches and methods, progress made, and remaining challenges. To provide a framework for understanding the enabling scientific principles, we first examine the elements and features of normal heart valve functional structure, biomechanics, development, maturation, remodeling, and response to injury. Following a discussion of the fundamental principles of tissue engineering applicable to heart valves, we examine three approaches to achieving the goal of an engineered tissue heart valve: (1) cell seeding of biodegradable synthetic scaffolds, (2) cell seeding of processed tissue scaffolds, and (3) in-vivo repopulation by circulating endogenous cells of implanted substrates without prior in-vitro cell seeding. Lastly, we analyze challenges to the field and suggest future directions for both preclinical and translational (clinical) studies that will be needed to address key regulatory issues for safety and efficacy of the application of tissue engineering and regenerative approaches to heart valves. Although modest progress has been made toward the goal of a clinically useful tissue engineered heart valve, further success and ultimate human benefit will be dependent upon advances in biodegradable polymers and other scaffolds, cellular manipulation, strategies for rebuilding the extracellular matrix, and techniques to characterize and potentially non-invasively assess the speed and quality of tissue healing and remodeling.
Nitrogen fixation by Oscillatoria spp. under autotrophic and photoheterotrophic conditions (1991)

Summary: Oscillatoria spp. UCSB8 and UCSB25 are both capable of aerobic N 2 fixation. The optimum temperature for C 2 H 2 reduction was 22 °C for Oscillatoria sp. UCSB8 and 35 °C for Oscillatoria sp. UCSB25, whilst the optimum temperature for growth on N 2 was 25 °C and 30 °C, respectively. In Oscillatoria sp. UCSB25, but not in UCSB8, inhibition of N 2 fixation may limit diazotrophic growth at temperatures above 35 °C. When grown under alternating 12 h light and 12 h darkness, both isolates reduced C 2 H 2 predominantly in the dark and both were capable of N 2 fixation and photoheterotrophic growth in the presence of 20 μm-DCMU to inhibit photosystem II activity. Under these conditions, the best exogenous carbon source for Oscillatoria sp. UCSB8 was glucose, whilst that for Oscillatoria sp. UCSB25 was fructose. In Oscillatoria sp. UCSB8, exogenous glucose was catabolized mainly through the oxidative pentose phosphate pathway. Although cultures grown photoheterotrophically showed higher specific activities of nitrogenase than photoautotrophic cultures, they grew more slowly. Furthermore, cultures grown photoheterotrophically under alternating light and darkness reduced C 2 H 2 both in the light and in the dark, but the highest rates of C 2 H 2 reduction were observed in the dark. This cyclic pattern of N 2 fixation was independent of photosystem II activity.