Androgens, Lipids, and Cardiovascular Risk (1992)

Editorials15 November 1992Androgens, Lipids, and Cardiovascular RiskStephen R. Plymate, MD, Ronald S. Swerdloff, MDStephen R. Plymate, MD, Ronald S. Swerdloff, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-10-871 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe incidence of coronary artery disease is significantly higher in men than in women until menopause, after which the incidence of coronary disease is similar in both sexes. Most commonly, these gender differences have been explained by the hormonal milieu and, most specifically, by the actions of sex steroids on the lipid profile. Certainly, the serum high-density lipoprotein (HDL) cholesterol level is lower and triglyceride levels are higher in eugonadal men than in premenopausal women (1). No sex-related differences in serum HDL cholesterol or triglyceride levels have been observed in prepubertal children (2). During male adolescence, plasma HDL cholesterol levels...References1. Heiss G, Johnson N, Rellans S, Davis C, and Tyroler H. The epidemiology of plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Summary. Circulation. 1980;62:IV116-36. MedlineGoogle Scholar2. Morrison J, deGroot I, Edwards B, Kelley K, Rauh J, and Melhies M. Plasma cholesterol and triglyceride levels in 6,775 school children ages 6-17. Metabolism. 1977;26:1199-211. CrossrefMedlineGoogle Scholar3. Laskarzewski P, Morrison J, Gutnai J, Orchard T, Khoury P, and Glueck C. High and low density lipoprotein cholesterols in adolescent boys: relationships with endogenous testosterone, estradiol, and Quetetet index. Metabolism. 1983;32:262-71. CrossrefMedlineGoogle Scholar4. Stampfer M, Golditz G, Willett W, Manson J, Rosner B, and Speizer F. 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The effects of hyperinsulinemia on serum testosterone, progesterone, dehydroepiandrosterone sulfate, and Cortisol levels in normal women and in a woman with hyperandrogenism, insulin resistance, and acanthosis nigricans. J Clin Endocrinol Metab. 1987;64:180-4. CrossrefMedlineGoogle Scholar13. Peiris A, Stagner J, Plymate S, Vogel R, Heck M, and Samols E. Relationship of insulin secretory pulses to sex hormone-binding globulin levels in normal men. J Clin Endocrinol Metab. [In press]. Google Scholar14. Hobbs C, Plymate S, Bell B, and Patience T. The effect of androgens on glucose tolerance. Proceedings of the American Federation of Clinical Research, 1991, Seattle, Washington [Abstract]. Google Scholar15. Friedl K, Hannan C, Jones R, and Plymate S. High-density lipoprotein cholesterol is not decreased if an aromatizable androgen is administered. Metabolism. 1990;39:69-74. CrossrefMedlineGoogle Scholar16. Friedl K, Jones R, Hannan C, and Plymate S. The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J Clin Endocrinol Metab. 1989;68:971-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Stephen R. Plymate, MD; Ronald S. Swerdloff, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetabolic Syndrome in Men with Klinefelter's SyndromeInterrelações entre SHBG e esteróides sexuais com medidas antropométricas, pressão arterial e lipídeos em mulheres com e sem diabetes mellitus tipo 2Effects of long-term use of testosterone enanthate. II. Effects on lipids, high and low density lipoprotein cholesterol and liver function parametersContraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal menLipoprotein profiles and glucose tolerance in lean and obese chimpanzees 15 November 1992Volume 117, Issue 10 Page: 871-872 Keywords Cardiovascular disease risk Cholesterol Coronary arteries High density lipoprotein Lipid profiles Lipids Menopause Sexual identity Stable coronary artery disease Steroids ePublished: 1 December 2008 Issue Published: 15 November 1992 PDF downloadLoading ...