gebhart/patrepeval huggingface dataset:
Sequential test strategies for multiple fault isolation (2002)

In this paper, we consider the problem of constructing near-optimal test sequencing algorithms for diagnosing multiple faults in redundant (fault-tolerant) systems. The computational complexity of solving the optimal multiple-fault isolation problem is super-exponential, that is, it is much more difficult than the single-fault isolation problem, which, by itself, is NP-hard. By employing concepts from information theory and Lagrangian relaxation, we present several static and dynamic (on-line or interactive) test sequencing algorithms for the multiple fault isolation problem that provide a trade-off between the degree of suboptimality and computational complexity. Furthermore, we present novel diagnostic strategies that generate a static diagnostic directed graph (digraph), instead of a static diagnostic tree, for multiple fault diagnosis. Using this approach, the storage complexity of the overall diagnostic strategy reduces substantially. Computational results based on real-world systems indicate that the size of a static multiple fault strategy is strictly related to the structure of the system, and that the use of an on-line multiple fault strategy can diagnose faults in systems with as many as 10,000 failure sources.
Diagnostic Value of Anti‐GBV‐C Antibodies in HIV‐Infected Patients (2011)

The beneficial effect of co-infection by GB virus C (GBV-C) in the course of the disease in human immunodeficiency virus (HIV)-infected patients has been described, although its mechanism of action is yet to be determined. The role of anti-GBV-C antibodies in HIV-infected patients also remains unknown. At present, there are no commercial systems to detect specific markers of GBV-C infection. The research presented follows our previous work from which we obtained chimeric molecules formed by two domains of different GBV-C proteins with good sensitivity/specificity balances in the detection of anti-GBV-C antibodies in hemodialyzed and chronic hepatitis patient samples. It has been investigated the ability of the synthetic peptides to recognize specific anti-GBV-C antibodies in HIV and HCV/HIV co-infected patients by a peptide-based ELISA immunoassay. The results showed that human immunodeficiency virus-infected patients have a significantly higher frequency of anti-GBV-C antibodies than healthy controls. A comparison between HCV(+) /HIV(+) and HCV(-) /HIV(+) was analyzed. Although a higher percentage of HCV/HIV-positive sera were positive for antibodies against GBV-C peptides, the difference was not significant. The presence of anti-GBV-C antibodies could represent a good marker of exposure to GBV-C in HIV-infected patients to facilitate a further analysis of the effect of this exposure in the progression of illness caused by HIV infection.
Low‐density lipoprotein subclass patterns and lipoprotein response to a reduced‐fat diet in men (1994)

Low-density lipoprotein (LDL) subclass pattern B is a common genetically influenced lipoprotein profile characterized by a predominance of small, dense LDL particles, and associated with increased levels of triglyceride-rich lipoproteins, reductions in high-density lipoprotein cholesterol (HDL-C), and increased risk of coronary artery disease compared to individuals with a predominance of larger LDL (pattern A). We sought to determine whether LDL subclass patterns are associated with response of plasma lipoprotein levels to changes in dietary fat and carbohydrate content. In a randomized cross-over study, 105 men consumed, for six weeks each, high-fat (46%) and low-fat (24%) solid food diets, with replacement of fat by carbohydrate. Diet-induced changes in subjects who exhibited pattern B (n = 18) following the high-fat diet differed significantly from those in subjects with pattern A (n = 87): in pattern B subjects LDL cholesterol (LDL-C) reductions were two-fold greater and plasma apolipoprotein (apo) B levels decreased significantly. These differences remained significant after adjustment for levels of plasma LDL-C, apo B, HDL-C, and body mass index. Thus, LDL subclass pattern is a factor that contributes significantly to interindividual variation of plasma lipoprotein response to a low-fat, high-carbohydrate diet.
Distribution of [3H]trans-resveratrol in rat tissues following oral administration (2006)

Resveratrol has been widely investigated for its potential health properties, although little is known about its metabolism in vivo. Here we investigated the distribution of metabolic products of [3H]trans-resveratrol, following gastric administration. At 2 h, plasma concentrations reached 1.7 % of the administered dose, whilst liver and kidney concentrations achieved 1.0 and 0.6 %, respectively. Concentrations detected at 18 h were lower, being only 0.5 % in plasma and a total of 0.35 % in tissues. Furthermore, whilst kidney and liver concentrations fell to 10 and 25 %, respectively, of concentrations at 2 h, the brain retained 43 % of that measured at 2 h. Resveratrol-glucuronide was identified as the major metabolite, reaching 7 microm in plasma at 2 h. However, at 18 h the main form identified in liver, heart, lung and brain was native resveratrol aglycone, indicating that it is the main form retained in the tissues. No phenolic degradation products were detected in urine or tissues, indicating that, unlike flavonoids, resveratrol does not appear to serve as a substrate for colonic microflora. The present study provides additional information about the nature of resveratrol metabolites and which forms might be responsible for its in vivo biological effects.
Performance Evaluation and Applications of ATM Networks (2002)

Information Highways are widely considered as the next generation of high speed communication systems. These highways will be based on emerging Broadband Integrated Services Digital Networks (B-ISDN), which - at least in principle - are envisioned to support not only all the kinds of networking applications known today but also future applications which are not as yet understood fully or even anticipated. Thus, B-ISDNs release networking processes from the limitations which the communications medium has imposed historically. The operational generality stems from the versatility of Asynchronous Transfer Mode (ATM) which is the transfer mode adopted by ITU-T for broadband public ISDN as well as wide area private ISDN. A transfer mode which provides the transmission, multiplexing and switching core that lies at the foundations of a communication network. ATM is designed to integrate existing and future voice, audio, image and data services. Moreover, ATM aims to minimise the complexity of switching and buffer management, to optimise intermediate node processing and buffering and to bound transmission delays. These design objectives are met at high transmission speeds by keeping the basic unit of ATM transmission - the ATM cell - short and of fixed length
How Useful Is Body Mass Index for Comparison of Body Fatness across Age, Sex, and Ethnic Groups? (1996)

This study tested the hypothesis that body mass index (BMI) is representative of body fatness independent of age, sex, and ethnicity. Between 1986 and 1992, the authors studied a total of 202 black and 504 white men and women who resided in or near New York City, were ages 20-94 years, and had BMIs of 18-35 kg/m2. Total body fat, expressed as a percentage of body weight (BF%), was assessed using a four-compartment body composition model that does not rely on assumptions known to be age, sex, or ethnicity dependent. Statistically significant age dependencies were observed in the BF%-BMI relations in all four sex and ethnic groups (p values < 0.05-0.001) with older persons showing a higher BF% compared with younger persons with comparable BMIs. Statistically significant sex effects were also observed in BF%-BMI relations within each ethnic group (p values < 0.001) after controlling first for age. For an equivalent BMI, women have significantly greater amounts of total body fat than do men throughout the entire adult life span. Ethnicity did not significantly influence the BF%-BMI relation after controlling first for age and sex even though both black women and men had longer appendicular bone lengths relative to stature (p values < 0.001 and 0.02, respectively) compared with white women and men. Body mass index alone accounted for 25% of between-individual differences in body fat percentage for the 706 total subjects; adding age and sex as independent variables to the regression model increased the variance (r2) to 67%. These results suggest that BMI is age and sex dependent when used as an indicator of body fatness, but that it is ethnicity independent in black and white adults.
Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome (1994)

Altered polymorphonuclear leukocyte (PMN) function is thought to contribute to organ dysfunction during the systemic inflammatory response syndrome (SIRS). To test this hypothesis, we evaluated whole blood PMN function adherent to fibronectin or laminin in patients with mild or severe acute pancreatitis as a paradigm for sirs. Whole-blood PMN intracellular H2O2 production, expression of CD32w (Fc gamma R II), CD16 (Fc gamma R III), and phagocytosis were performed using dichlorofluorescein diacetate, fluorescein isothiocyanate-labeled anti- CD32w, CD16, and serum-opsonized fluorescent microspheres. Group I (n x 7) represents normal control individuals; group II (n x 11) represents patients with mild acute pancreatitis. Group III (n x 15) represents critically ill patients with severe acute pancreatitis. Adherence of PMN from groups I and II to matrix proteins resulted in a 5% to 20% increase in each PMN function assayed whereas adherence of PMN from group III to matrix proteins resulted in 50% to 75% increases in each PMN function assayed. Pertussis toxin, pentoxifylline, and dibutyryl cyclic adenosine monophosphate (cAMP) each reduced group I-II H2O2 production and phagocytosis. Pentoxifylline and dibutyryl cAMP but not pertussis toxin reduced group III H2O2 production. Both intracellular H2O2 and phagocytosis assays from group III but not groups I-II showed exaggerated upregulation when exposed to NaF (4 mmol/L). Anti- interleukin-6 reduced the increase in intracellular H2O2 production in group III patients and significantly altered the exaggerated oxidative response to NaF. Longitudinal studies of group III whole-blood PMN showed persistent upregulation of intracellular H2O2 production in those patients whose hospital courses were complicated by multiple system organ failure. These results demonstrate abnormal whole blood PMN function during the systemic inflammatory response syndrome in the presence of fibronectin, or laminin and that this is mediated in part via a pertussis toxin insensitive altered guanosine triphosphate- binding protein.
Room temperature synthesis of free-standing HKUST-1 membranes from copper hydroxide nanostrands for gas separation (2013)

Large scale, robust, well intergrown free-standing HKUST-1 membranes were converted from copper hydroxide nanostrand free-standing films in 1,3,5-benzenetricarboxylic acid water-ethanol solution at room temperature, and explored for gas separation. The truncated crystals are controllable and favorable for the dense intergrowth.
A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli. (1995)

The regulation of capsular polysaccharide synthesis in Escherichia coli K-12 depends on the level of an unstable positive regulator, RcsA. The amount of RcsA protein is limited both by its rapid degradation by Lon, an ATP-dependent protease, and by its low level of synthesis. We have found that the low level of expression from the rcsA promoter is due to transcriptional silencing by the histone-like protein H-NS; this silencing is sensitive to both sequence and context in a region upstream of the -35 region of the promoter. A small (85-nt) RNA, DsrA, when overproduced, activates transcription of rcsA::lacZ fusions by counteracting H-NS silencing. DsrA RNA does not show any extended homology with the rcsA promoter or other sequenced regions of E. coli. Since the stimulation of rcsA transcription by this small RNA does not depend on any sequences from within the rcsA transcript, DsrA acts, either directly or indirectly, on rcsA transcription initiation.
Use of Tandem Mass Spectrometry for Multianalyte Screening of Dried Blood Specimens from Newborns (2003)

Multianalyte technologies such as MS/MS are suitable for newborn screening and other mass screening programs because they improve the detection of many diseases in the current screening panel while enabling expansion to disorders that are now recognized as important and need to be identified in pediatric medicine.
CYCLIC SUBGROUP SEPARABILITY OF HNN EXTENSIONS (1993)

In [4], Baumslag and Tretkoff proved a residual finiteness criterion for HNN extensions (Theorem 1.2, below). This result has been used extensively in the study of the residual finiteness of HNN extensions. Note that every one-relator group can be embedded in a one-relator group whose relator has zero exponent sum on a generator, and the latter group can be considered as an HNN extension. Hence the properties of an HNN extension play an important role in the study of one-relator groups [3], [2]. In this paper we prove a criterion for HNN extensions to be .pi.(Theorem 2.2). Moreover, we can prove that certain one-relator groups, known to be residually finite, are actually .pi.. It was known by Mostowski [10] that the word problem is solvable for finitely presented, residually finite groups. In the same way, the power problem is solvable for finitely presented .pi. groups. Another application of subgroup separability with respect to special subgroups was mentioned by Thurston [12, Problem 15].m 15].
An electrostatic basis for the stability of thermophilic proteins (2004)

Two factors provide key contributions to the stability of thermophilic proteins relative to their mesophilic homologues: electrostatic interactions of charged residues in the folded state and the dielectric response of the folded protein. The dielectric response for proteins in a "thermophilic series" globally modulates the thermal stability of its members, with the calculated dielectric constant for the protein increasing from mesophiles to hyperthermophiles. This variability results from differences in the distribution of charged residues on the surface of the protein, in agreement with structural and genetic observations. Furthermore, the contribution of electrostatic interactions to the stability of the folded state is more favorable for thermophilic proteins than for their mesophilic homologues. This leads to the conclusion that electrostatic interactions play an important role in determining the stability of proteins at high temperatures. The interplay between electrostatic interactions and dielectric response also provides further rationalization for the enhanced stability of thermophilic proteins with respect to cold-denaturation. Taken together, the distribution of charged residues and their fluctuations have been shown to be factors in modulating protein stability over the entire range of biologically relevant temperatures.
Controlling the Stability and Reversibility of Micropillar Assembly by Surface Chemistry (2011)

For many natural and synthetic self-assembled materials, adaptive behavior is central to their function, yet the design of such systems has mainly focused on the static form rather than the dynamic potential of the final structure. Here we show that, following the initial evaporation-induced assembly of micropillars determined by the balance between capillarity and elasticity, the stability and reversibility of the produced clusters are highly sensitive to the adhesion between the pillars, as determined by their surface chemistry and further regulated by added solvents. When the native surface of the epoxy pillars is masked by a thin gold layer and modified with monolayers terminated with various chemical functional groups, the resulting effect is a graded influence on the stability of cluster formation, ranging from fully disassembled clusters to an entire array of stable clusters. The observed assembly stabilization effect parallels the order of the strengths of the chemical bonds expected to form by the respective monolayer end groups: NH(2) ≈ OH < COOH < SH. For each functional group, the stability of the clusters can be further modified by varying the carbon chain length of the monolayer molecules and by introducing solvents into the clustered samples, allowing even finer tuning as well as temporal control of disassembly. Using these features together with microcontact printing, we demonstrate straightforward patterning of the microstructured surfaces with clusters that can be erased and regenerated at will by the addition of appropriate solvents. Subtle modifications to surface and solvent chemistry provide a simple way to tune the balance between adhesion and elasticity in real time, enabling structures to be designed for dynamic, responsive behavior.
The Response of Metastatic Adenocarcinoma of the Prostate to Exogenous Testosterone (1981)

In a retrospective review the response of 67 patient with metastatic adenocarcinoma of the prostate to the administration of exogenous testosterone was analyzed. Among 52 patients in whom objective and/or subjective responses were evaluable 45 experienced unfavorable responses. There was prompt regression of most unfavorable responses with testosterone withdrawal. The duration of treatment required to evoke an unfavorable response was related to the clinical status of the patient. Twenty-five per cent of patients with symptomatic metastases who had received no prior treatment, 36 per cent in symptomatic remission after endocrine therapy and 94 per cent with symptomatic relapse after endocrine therapy experienced unfavorable responses within 30 days of treatment. No patient had objective evidence of tumor regression during testosterone therapy but 7 patients, 6 with remission and 1 untreated, experienced symptomatic benefit. We conclude that the response of patients with metastatic prostate cancer to exogenous testosterone is related to the mass and endocrine treatment status, and that exogenous testosterone can stimulate prostatic neoplasms that proliferate in the absence of normal endogenous testosterone levels.
Fracture/dissociation of the polyethylene in metal-backed patellar components in total knee arthroplasty. (1988)

We encountered a complication that is unique to the use of a metal-backed patellar component in total knee replacement--namely, fracture and separation of the polyethylene bearing from its metal counterpart. The cases of seventeen patients who were treated at several institutions were studied. Patellar malalignment, especially in heavy patients who had a high level of activity, was a contributory cause of the complication, but we thought that deficiencies in the design of the prosthesis were also an important factor.
Silicon in synthesis. 14. (Methoxy(trimethylsilyl)methyl)lithium. A new reagent for carbonyl homologation (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilicon in synthesis. 14. (Methoxy(trimethylsilyl)methyl)lithium. A new reagent for carbonyl homologationPhilip Magnus and Glenn RoyCite this: Organometallics 1982, 1, 3, 553–559Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/om00063a027https://doi.org/10.1021/om00063a027research-articleACS PublicationsRequest reuse permissionsArticle Views607Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IRAK signalling in cancer (2014)

Innate immune signalling has an essential role in inflammation, and the dysregulation of signalling components of this pathway is increasingly being recognised as an important mediator in cancer initiation and progression. In some malignancies, dysregulation of inflammatory toll-like receptor (TLR) and interleukin-1 receptor (IL1R) signalling is typified by increased NF-κB activity, and it occurs through somatic mutations, chromosomal deletions, and/or transcriptional deregulation. Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer targets. Although there have been previous efforts aimed at the development of IRAK kinase inhibitors, this is currently an area of renewed interest for cancer drug development.
Logging Horizontal Wells – Field Practice for Various Techniques (1987)

ABSTRACT With the development of highly deviated and horizontal wells, new techniques of running logging tools have been developed, in addition to the wire line method, for conveying logging tools in wells. Five techniques are now operational: the wire line, the MWD, the SIMPHOR* type methods, the Pump DownStinger and the Coiled Tubing method. Logging by wire line is naturally restricted to well inclinations up to 65° to 70°. By the fact that they use the drill pipes, the SIMPHOR and MWD type techniques are theoretically capable of covering all conventionally drilled wells, whatever their deviation or horizontal development. With the use of a telescopic stinger, only small diameter or production tools can be used. As for coiled tubing, its relative fragility will limit its use, to deviated wells with standard tools, and to low horizontal offset drains with lighter tools. The latter two methods offer the advantage of being operable without a drilling rig. ELF-AQUITAINE's experience in using these different techniques on horizontal drains amounts to the following today: – ten horizontal wells drilled, of which six used the MWD method in the reservoir, – nine logging operations with SIMPHOR systems, – eight with the pump-down stinger, of which four on production logging, – two operations with coiled tubing. (It should be noted that a single operation can comprise several running-in operations). In addition to the horizontal wells, these methods naturally lend themselves to all highly deviated or difficult wells where wire line working is not possible, thus endowing them with a wide range of application.
Vascular endothelial growth factors and their receptors in embryos, adults and in tumors (1999)

These authors contributed equally to the work.al., 1992), suggesting that bFGF-HSPG complexes serve as the biological active form of this growth factor.Cell surface heparin-like molecules are also involved in binding of VEGF to its high affinity receptor sites