gebhart/patrepeval huggingface dataset:
Differential Outcome of Tolerance Induction in Naive versus Activated Theiler's Virus Epitope-Specific CD8+Cytotoxic T Cells (2007)

Tolerance induced by the intravenous injection of peptide-pulsed, ethylene carbodiimide (ECDI)-fixed splenic antigen-presenting cells (Ag-SP) is a safe and effective method of inducing specific unresponsiveness in CD4+ T cells for the prevention and treatment of a variety of autoimmune diseases. We determined whether Ag-SP tolerance could also be used to tolerize CD8+ T cells. We show in the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model of multiple sclerosis that CD8+ T cells specific for both dominant and subdominant epitopes can be rendered tolerant. Interestingly, although virus clearance was delayed, lack of the virus-specific cytotoxic T-lymphocyte response did not result in the conversion of normally TMEV-resistant C57BL/6 mice to a susceptible phenotype. Importantly, we found that Ag-SP tolerance may not be a practical treatment for human diseases in which CD8+ T cells play a major role in pathogenesis, as tolerance induction in mice previously infected with TMEV led to a severe, often fatal reaction.
Thermally bandwidth-controllable reflective polarizers from (polymer network/liquid crystal/chiral dopant) composites (2003)

A (polymer network/nematic liquid crystal/chiral dopant) composite exhibiting a chiral nematic (N*) phase at room temperature has been developed. Because the helical twisting power of the chiral dopant increases with increasing temperature and the polymer network affects the molecular rearrangement of the liquid crystal, the bandwidth of the selective reflection spectrum of the N* phase becomes wider and narrower reversibly with increasing and decreasing temperature, respectively.
Chemical carcinogenesis (2007)

The use of chemical compounds benefits society in a number of ways. Pesticides, for instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of people, a condition that has led to an increase in levels of life expectancy. Yet, at times, these benefits are offset by certain disadvantages, notably the toxic side effects of the chemical compounds used. Exposure to these compounds can have varying effects, ranging from instant death to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis. These are defined as initiation, promotion and progression. Each of these stages is characterised by morphological and biochemical modifications and result from genetic and/or epigenetic alterations. These genetic modifications include: mutations in genes that control cell proliferation, cell death and DNA repair--i.e. mutations in proto-oncogenes and tumour suppressing genes. The epigenetic factors, also considered as being non-genetic in character, can also contribute to carcinogenesis via epigenetic mechanisms which silence gene expression. The control of responses to carcinogenesis through the application of several chemical, biochemical and biological techniques facilitates the identification of those basic mechanisms involved in neoplasic development. Experimental assays with laboratory animals, epidemiological studies and quick tests enable the identification of carcinogenic compounds, the dissection of many aspects of carcinogenesis, and the establishment of effective strategies to prevent the cancer which results from exposure to chemicals.
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. (1990)

Insulin-dependent diabetes mellitus is caused by autoimmune destruction of the insulin-producing beta cells of the pancreas. The results described here indicate that a beta-cell target antigen in non-obese diabetic (NOD/Lt) mice is a molecule cross-reactive with the 65-kDa heat shock protein (hsp65) of Mycobacterium tuberculosis. The onset of beta-cell destruction is associated with the spontaneous development of anti-hsp65 T lymphocytes. Subsequently hsp65 cross-reactive antigen becomes detectable in the sera of the prediabetic mice and some weeks later anti-hsp65 antibodies, anti-insulin antibodies, and anti-idiotypic antibodies to insulin antibodies become detectable. The hsp65-cross-reactive antigen, the autoantibodies, and the T-cell reactivity then decline with the development of overt insulin-dependent diabetes. The importance of hsp65 in the pathogenesis of insulin-dependent diabetes was confirmed by the ability of clones of anti-hsp65 T cells to cause insulitis and hyperglycemia in young NOD/Lt mice. Moreover, hsp65 antigen could be used either to induce diabetes or to vaccinate against diabetes, depending on the form of its administration to prediabetic NOD/Lt mice. Other antigens such as the 70-kDa heat shock protein (hsp70) had no effect on the development of diabetes.
Text Segmentation Using Exponential Models (1997)

This paper introduces a new statistical approach to partitioning text automatically into coherent segments. Our approach enlists both short-range and long-range language models to help it sniff out likely sites of topic changes in text. To aid its search, the system consults a set of simple lexical hints it has learned to associate with the presence of boundaries through inspection of a large corpus of annotated data. We also propose a new probabilistically motivated error metric for use by the natural language processing and information retrieval communities, intended to supersede precision and recall for appraising segmentation algorithms. Qualitative assessment of our algorithm as well as evaluation using this new metric demonstrate the effectiveness of our approach in two very different domains, Wall Street Journal articles and the TDT Corpus, a collection of newswire articles and broadcast news transcripts.
Prevalence of Mild Cognitive Impairment and Its Subtypes in the Heinz Nixdorf Recall Study Cohort (2010)

Prevalence rates of MCI are high in the general population and vary considerably according to the criteria applied.
Building effective queries in natural language information retrieval (1997)

In this paper we report on our natural language information retrieval (NLIR) project as related to the recently concluded 5th Text Retrieval Conference (TREC-5). The main thrust of this project is to use natural language processing techniques to enhance the effectiveness of full-text document retrieval. One of our goals was to demonstrate that robust if relatively shallow NLP can help to derive a better representation of text documents for statistical search. Recently, we have turned our attention away from text representation issues and more towards query development problems. While our NLIR system still performs extensive natural language processing in order to extract phrasal and other indexing terms, our focus has shifted to the problems of building effective search queries. Specifically, we are interested in query construction that uses words, sentences, and entire passages to expand initial topic specifications in an attempt to cover their various angles, aspects and contexts. Based on our earlier results indicating that NLP is more effective with long, descriptive queries, we allowed for long passages from related documents to be liberally imported into the queries. This method appears to have produced a dramatic improvement in the performance of two different statistical search engines that we tested (Cornell's SMART and NIST's Prise) boosting the average precision by at least 40%. In this paper we discuss both manual and automatic procedures for query expansion within a new stream-based information retrieval model.
Neurological deterioration in adult phenylketonuria (1988)

A 28-year-old man with classical phenylketonuria had increased seizure frequency and rapidly progressive spasticity. There was a marked reduction of biogenic amine neurotransmitter metabolites in cerebrospinal fluid. Dietary therapy reduced serum phenylalanine levels, improved symptoms of hypertonicity, and cerebrospinal fluid neurotransmitter metabolites became normal. An adolescent male with classical phenylketonuria, treated by dietary restriction until age 6 years, was assessed for decreasing school performance at 18 years. Cerebrospinal fluid biogenic amine neurotransmitter metabolites were significantly reduced. Magnetic resonance imaging in both subjects showed multiple areas of increased signal intensity in cerebral white matter. Neuropathological changes in classical phenylketonuria have been characterized as a dysmyelinating or demyelinating process. Neurochemical studies show a defect in brain lipids and biogenic amine metabolism. In the past, dietary therapy was directed at reducing hyperphenylalaninaemia only during the first decade of life. This report, as well as other studies, indicates that dietary therapy should be lifelong in patients with classical phenylketonuria, in order to prevent progressive and insidious neurological deterioration in later life.
Measurement of Damages at Bypass Diodes by Induced Voltages and Currents in PV Modules Caused by Nearby Lightning Currents With Standard Waveform (2008)

In 1990 – 1993 and during an EU project in 1998 – 2000, the PV laboratory of BFH-TI has carried out tests about sensitivity of PV modules against lightning currents flowing in or close to the frame of a PV module [1], [2], [3]. For these tests, impulse currents with imax ≤ 120kA and di/dtmax ≤ 40kA/μs were used. It could be shown that even at moderate distances the voltages induced in a module by such lightning currents may go up to several thousand volts. Such voltages can easily destroy bypass diodes. Due to increasing cell dimensions and currents, more and more Schottky diodes are used as bypass diodes, which have only quite low reverse voltage ratings between 40 V and 100 V. In practical operation, such damages actually occur, but usually only at considerably higher peak induced voltages than the reverse voltage rating of the Schottky diode. In [5] and [7] the problem was analysed theoretically and the results of some first tests with short impulse currents (about 8μs/20μs) were shown. In this paper, the theoretical analysis is extended and results of many measurements performed in 2007 and 2008 with impulse current waveforms of about 6μs/350μs (di/dtmax ≤ 30kA/μs) at different modules and with different diode types are presented.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. (1988)

47 tumor samples, 45 of which were obtained at thoracotomy for non-small cell lung cancer were examined for mutational activation of the oncogenes H-ras, K-ras, and N-ras. A novel, highly sensitive assay based on oligonucleotide hybridization following an in vitro amplification step was employed. ras gene mutations were present in nine of 35 adenocarcinomas of the lung (all K-ras), in two of two lung metastases of colorectal adenocarcinomas (1 x K-ras, 1 x N-ras) and in one adenocarcinoma sample obtained at autopsy (H-ras). All K-ras and H-ras mutations were in either position 1 or 2 of codon 12, while the N-ras mutation was in position 2 of codon 61. The potential clinical significance of K-ras activation was analyzed using the combined results of this and of our earlier study (S. Rodenhuis et al., New Engl. J. Med., 317: 929-935, 1987). Lung adenocarcinomas with K-ras mutations tended to be smaller and were less likely to have spread to regional lymph nodes at presentation. With a median follow up of 10 months, survival data are still immature. None of six adenocarcinomas of nonsmokers had a K-ras mutation and only one of four who had stopped smoking more than 5 years before. We conclude that mutational K-ras activation is present in about a third of adenocarcinomas of the lung and that the mutational event may be a direct result of one or more carcinogenic ingredients of tobacco smoke. Studies involving larger numbers of patients are required to confirm the association of K-ras activation with smoking and the inverse relation with tumor progression.
End-to-End Speech-Driven Facial Animation with Temporal GANs (2018)

Speech-driven facial animation is the process which uses speech signals to automatically synthesize a talking character. The majority of work in this domain creates a mapping from audio features to visual features. This often requires post-processing using computer graphics techniques to produce realistic albeit subject dependent results. We present a system for generating videos of a talking head, using a still image of a person and an audio clip containing speech, that doesn't rely on any handcrafted intermediate features. To the best of our knowledge, this is the first method capable of generating subject independent realistic videos directly from raw audio. Our method can generate videos which have (a) lip movements that are in sync with the audio and (b) natural facial expressions such as blinks and eyebrow movements. We achieve this by using a temporal GAN with 2 discriminators, which are capable of capturing different aspects of the video. The effect of each component in our system is quantified through an ablation study. The generated videos are evaluated based on their sharpness, reconstruction quality, and lip-reading accuracy. Finally, a user study is conducted, confirming that temporal GANs lead to more natural sequences than a static GAN-based approach.
THE USE OF DOLORIMETRY IN THE ASSESSMENT OF POST-TRAUMATIC ALGODYSTROPHY OF THE HAND (1989)

We have investigated the use of dolorimetry in the assessment of algodystrophy of the hand. Findings in 12 affected patients following Colles' fracture were compared with age- and sex-matched normal controls. Algodystrophy was associated with a significant increase in tenderness of both the finger joints and bones. Tenderness of the whole hand was quantified by summing the dolorimetry readings at each site within the hand and the ratio of the summed readings for the two hands was defined as the dolorimetry ratio. This ratio was highly reproducible and independent of external variables. It was significantly lower in patients with algodystrophy than in controls and may provide a method for the diagnosis and serial assessment of the disorder.
RecombinantBacillus subtilisExpressing theClostridium perfringensAlpha Toxoid Is a Candidate Orally Delivered Vaccine against Necrotic Enteritis (2008)

Recombinant Bacillus subtilis endospores have been used to vaccinate against tetanus and anthrax. In this work, we have developed spores that could be used to vaccinate against Clostridium perfringens alpha toxin and that could be used to protect against gas gangrene in humans and necrotic enteritis in poultry. The primary active agent in both cases is alpha toxin. A carboxy-terminal segment of the alpha toxin gene (cpa) fused to the glutathione-S-transferase (GST) gene was cloned in B. subtilis such that the encoded GST-Cpa(247-370) polypeptide had been expressed in the following three different ways: expression in the vegetative cell, expression on the surface of the spore coat (fused to the CotB spore coat protein), and a combined approach of spore coat expression coupled with expression in the vegetative cell. Mice immunized orally or nasally with three doses of recombinant spores that carried GST-Cpa(247-370) on the spore surface showed the most striking responses. This included seroconversion with anti-Cpa(247-370)-specific immunoglobulin G (IgG) responses in their sera, a Th2 bias, and secretory IgA responses in saliva, feces, and lung samples. Neutralizing IgG antibodies to alpha toxin were detected using in vitro and in vivo assays, and a toxin challenge established protection. Mice immunized nasally or orally with recombinant spores were protected against a challenge with 12 median lethal doses of alpha toxin. Existing use of spores as competitive exclusion agents in animal feeds supports their use as a potentially economical and heat-stable vaccine for the poultry industry.
Heat-Mediated Activation of Affinity-Immobilized Taq DNA Polymerase (1997)

A novel strategy for heat-mediated activation of recombinant Taq DNA polymerase is described. A serum albumin binding protein tag is used to affinity-immobilize an E. coli-expressed Taq DNA polymerase fusion protein onto a solid support coated with human serum albumin (HSA). Analysis of heat-mediated elution showed that elevated temperatures (> 70 degrees C) were required to significantly release the fusion protein from the solid support. A primer-extension assay showed that immobilization of the fusion protein resulted in little or no extension product. In contrast, fusion protein released from the HSA ligand by heat showed high polymerase activity. Thus, a heat-mediated release and reactivation of the Taq DNA polymerase fusion protein from the solid support can be obtained to allow for hot-start PCR with improved amplification performance.
42.3: Transparent ZnO Thin Film Transistor for the Application of High Aperture Ratio Bottom Emission AM‐OLED Display (2008)

Abstract We have fabricated 2.5″ QCIF + bottom emission AM‐OLED with aperture ratio of 59.6% using fully transparent ZnO‐TFT array and highly conductive oxide/metal/oxide electrode for the first time. The bias stability of ZnO TFT was improved by optimizing ZnO deposition and first gate insulator process. Plasma free process for the gate insulator makes ZnO TFT very stable under electrical bias stress. The Vth shift was less than 0.3V after V DS =25 V and V GS =15 V application for 60 hours. Transparent ZnO TFT characteristics did not change noticeably under irradiation of visible light.
The effect of Mg2+ on the guanine nucleotide exchange rate of p21N-ras. (1986)

There is growing evidence that the protein products of the ras gene family, p21ras, can couple growth factor receptors to intracellular second messenger production and in particular to phosphoinositol lipid turnover. So far, however, there has been no direct proof that the ras proteins function as typical regulatory G proteins. We show here that the human p21N-ras protein, isolated from an Escherichia coli expression system, can exist as a stable GDP complex which exchanges very slowly with exogenous GTP, the half-life of the p21N-ras X GDP complex being around 20 min. However, in low Mg2+ (0.5 microM) the exchange rate is dramatically increased and the half-life of the p21N-ras X GDP complex is less than 30 s. Furthermore, in low Mg2+, the relative binding affinity of the protein for GTP as compared to GDP is increased 10-fold. The effect of low Mg2+ on the exchange rate of both normal and oncogenic mutant p21ras molecules is identical. We propose that removal of Mg2+ in vitro induces a similar conformational change to stimulation in vivo. The properties described here are consistent with a G protein-like activity for p21N-ras.
A computer system for the analysis of dental casts. (1981)

Abstract Photographs of Dental casts provide the basis for digitization of major dental landmarks, enabling computerization of such descriptive parameters of occlusion as symmetry, mesiodistal relationships, overbite, overjet, curve of Spee, tooth/arch discrepancies, Bolton ratios, and rotations. Computing services used in this research were provided by the Computer Center, University of Illinois Chicago Circle Campus.
Protein Detection and Quantitation by Tetraphenylethene-Based Fluorescent Probes with Aggregation-Induced Emission Characteristics (2007)

Three functionalized derivatives of tetraphenylethylene (TPE), namely, 1,2-bis(4-methoxyphenyl)-1,2-diphenylethene (1), 1,2-bis(4-hydroxyphenyl)-1,2-diphenylethene (2), and 1,2-bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene sodium salt (3), were synthesized and their fluorescence properties were investigated. All the TPE molecules are nonluminescent in the solution state but are induced to emit efficiently by aggregate formation. This novel process of aggregation-induced emission (AIE) is rationalized to be caused by the restriction of intramolecular rotations of the dye molecules in the aggregate state. The possibility of utilizing the AIE effect for protein detection and quantification is explored using bovine serum albumin (BSA) as a model protein, with salt 3 being found to perform as a stable, sensitive, and selective bioprobe.
Adult Hypophosphatasia Treated with Teriparatide (2007)

This first HPP patient given TPTD demonstrated fracture repair accompanying correction of hypophosphatasemia and hyperphosphatemia and bone marker responses indicating enhanced skeletal remodeling. Increased TNSALP synthesis in bone together with lowered extracellular concentrations of inorganic phosphate (a competitive inhibitor of ALPs) seemed to improve her skeletal mineralization. Further evaluation of TPTD for HPP is warranted.
Crystal structure and optical properties of silver nanorings (2009)

We report the polyol synthesis and crystal structure characterization of silver nanorings, which have perfect circular shape, smooth surface, and elliptical wire cross-section. The characterization results show that the silver nanorings have well-defined crystal of singly twinned along the whole ring. The spatial distribution of the scattering of a silver nanoring with slanted incidence reveals the unique focus effect of the nanoring, and the focus scattering varies with the incident wavelength. The silver nanorings with perfect geometry and well-defined crystal have potential applications in nanoscaled photonics, plasmonic devices, and optical manipulation.
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase (1991)

The cross-linking of membrane IgM on the surface of splenic B lymphocytes or WEHI 231 cells leads to the rapid phosphorylation on tyrosine of a 72-kDa protein as detected in Western blotting experiments using anti-phosphotyrosine antibodies. The 72-kDa phosphoprotein detected in this manner comigrates, in both one- and two-dimensional polyacrylamide gel electrophoresis systems, with PTK72, a 72-kDa protein-tyrosine kinase characterized previously in this laboratory (Zioncheck, T. F., Harrison, M. L., Isaacson, C. C., and Geahlen, R. L. (1988) J. Biol. Chem. 263, 19195-19202). Anti-phosphotyrosine antibodies and anti-PTK72 antibodies immunoprecipitate the same protein-tyrosine kinase from extracts of anti-IgM-activated cells as determined by immune complex kinase assays and one-dimensional phosphopeptide mapping. These results indicate that the tyrosine phosphorylation of a 72-kDa protein-tyrosine kinase is an early event in the activation of B lymphocytes via the antigen receptor.
Quenching of Photoluminescence from Porous Silicon by Aromatic Molecules (1997)

A systematic study of the efficiency of photoluminescence (PL) quenching of nanocrystalline porous Si by aromatic triplet energy acceptors was carried out. The effects of molecular triplet energy, molecular size, and the porous Si emission energy on PL quenching efficiency were probed. Photoluminescent porous Si samples, prepared by electrochemical etch, were titrated with toluene solutions of anthracene, 9,10-diphenylanthracene, 9,10-dichloroanthracene, 9,10-dimethylanthracene, pyrene, 1,2-benzanthracene, acridine, and 1,4-diphenyl-1,3-butadiene, and the steady-state and time-resolved PL spectra were measured. The quenching of PL adequately fits a dynamic Stern−Volmer quenching model. The rate of quenching increases with increasing exoergicity, and then levels off at higher exoergicities. The mechanism of quenching is attributed to energy transfer from the porous Si excited state to the triplet levels of the quencher molecules. The rate of quenching can also be affected by the size of substituents on the quenchers; some molecules with larger substituents display slower quenching rates than expected from their triplet energies.