gebhart/patrepeval huggingface dataset:
Cyclic peptides as selective tachykinin antagonists (1993)

Twenty homodetic cyclic peptides based on the C-terminal sequence of substance P were prepared (Table I) by a combination of solid-phase techniques and cyclizations using azide coupling procedures. Incorporation of dipeptide mimics based on substituted gamma-lactams were used in some cases to restrict their conformational mobility. Five of these cyclic peptides were shown to have high tachykinin antagonist activity (pA2 > 6) at NK-2 receptors (rat vas deferens). The two most potent of this series, XVII, cyclo(Gln-Trp-Phe-Gly-Leu-Met) (pA2 = 8.1), and I cyclo(Gln-Trp-Phe(R)Gly[ANC-2]Leu-Met) (pA2 = 6.7), were selective for NK-2 receptors compared with the other tachykinin receptors (Table II).
Experimental Demonstration of a Coherently Modulated and Directly Detected Optical OFDM System Using an RF-Tone Insertion (2008)

We experimentally demonstrate an RF-tone assisted OFDM transmission. Our system has a 5-dB better sensitivity compared to the conventional baseband SSB-OFDM and exhibits a negligible penally transmission after 260 km of SSMF.
Robotic Surgery (2003)

Cleveland Clinic Foundation, Cleveland, Ohio Correspondence: Dr. Tommaso Falcone, Chairman, Dept. Obstetrics and Gynecology-A81, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195. E-mail:[email protected]
Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys (2006)

Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.
Battery Management Systems in Electric and Hybrid Vehicles (2011)

The battery management system (BMS) is a critical component of electric and hybrid electric vehicles. The purpose of the BMS is to guarantee safe and reliable battery operation. To maintain the safety and reliability of the battery, state monitoring and evaluation, charge control, and cell balancing are functionalities that have been implemented in BMS. As an electrochemical product, a battery acts differently under different operational and environmental conditions. The uncertainty of a battery’s performance poses a challenge to the implementation of these functions. This paper addresses concerns for current BMSs. State evaluation of a battery, including state of charge, state of health, and state of life, is a critical task for a BMS. Through reviewing the latest methodologies for the state evaluation of batteries, the future challenges for BMSs are presented and possible solutions are proposed as well.
A Weighted Adaptive Subtraction for Two or More Multiple Models (2010)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2010A Weighted Adaptive Subtraction for Two or More Multiple ModelsAuthors: Yan MeiZuihong ZouYan MeiPGS and Zuihong ZouPGShttps://doi.org/10.1190/1.3513573 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract Multiple prediction techniques commonly have strengths and weaknesses in different areas, and combining them can often achieve the twin goals of better multiple removal and less harm to the primary events. This paper discusses how to combine different multiple models together during the adaptive subtraction step to achieve the best outcome. Using synthetic and real data as examples, we show that a type of weighted subtraction with the weights based on the similarity between the multiples and the input data gives the best result when one multiple model is more reliable than the other one.Permalink: https://doi.org/10.1190/1.3513573FiguresReferencesRelatedDetailsCited byInversion-driven free surface multiple modelling using multi-order Green's functionsGordon Poole* and James Cooper19 August 2015Improved shallow water demultiple with 3D multi-model subtractionSimon R. Barnes*, Rob F. Hegge, Hana Schumacher, and Rebekah Brown19 August 2015Unary adaptive subtraction of joint multiple models with complex wavelet framesSergi Ventosa, Sylvain Le Roy, Irène Huard, Antonio Pica, and Laurent Duval25 October 2012An inversion approach to separating sources in marine simultaneous shooting acquisition - application to a Gulf of Mexico data set28 May 2012 | Geophysical Prospecting, Vol. 60, No. 4 SEG Technical Program Expanded Abstracts 2010ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2010 Pages: 4453 publication data© 2010 Copyright © 2010 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 21 Oct 2010 CITATION INFORMATION Yan Mei and Zuihong Zou, (2010), "A Weighted Adaptive Subtraction for Two or More Multiple Models," SEG Technical Program Expanded Abstracts : 3488-3492. https://doi.org/10.1190/1.3513573 Plain-Language Summary PDF DownloadLoading ...
Characterization of recombinant human .alpha.2-antiplasmin and of mutants obtained by site-directed mutagenesis of the reactive site (1987)

Human alpha 2-antiplasmin (alpha 2AP) has been expressed in Chinese hamster ovary cells and purified from conditioned media. The recombinant protein (r alpha 2AP) is immunologically identical with natural alpha 2AP and indistinguishable with respect to plasmin(ogen) binding properties. Second-order rate constants (k1) for the interaction of alpha 2AP and r alpha 2AP with plasmin are both (1-2) X 10(7) M-1 s-1. In order to examine the effects of alterations within the reactive site of alpha 2AP, deletions of the P1 residue Arg-364 (r alpha 2AP-delta Arg364) or the P'1 residue Met-365 (r alpha 2AP-delta Met365) were introduced by in vitro site-directed mutagenesis. r alpha 2AP-delta Met365 completely retains its ability to inhibit both plasmin and trypsin, indicating that alpha 2AP has no absolute requirement for Met in the P'1 position. Unexpectedly, no increase in antithrombin activity was observed. r alpha 2AP-delta Arg364 has lost the ability to inhibit plasmin, trypsin, and thrombin, but unlike the wild-type protein, this variant is an effective elastase inhibitor (k1 = 1.5 X 10(5) M-1 s-1).
CD8+T Cells: GITR Matters (2012)

As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system. CD8(+) T cells are key players in the immunity against viruses and tumors, and GITR has been demonstrated to be an essential molecule for these cells to mount an immune response. The aim of this paper is to focus on GITR function in CD8(+) cells, paying particular attention to numerous and recent studies that suggest its crucial role in mouse disease models.
Pulse-Gradient Spin-Echo 1H, 7Li, and 19F NMR Diffusion and Ionic Conductivity Measurements of 14 Organic Electrolytes Containing LiN(SO2CF3)2 (1999)

The self-diffusion coefficients of the lithium ion, the anion, and the solvent in lithium bis(trifluromethanesulfonyl)imide (LiTFSI, LiN(SO2CF3)2) solvent systems were measured using the pulse-gradient spin-echo (PGSE) NMR method. Fourteen different organic solvents that are commonly used as organic solution electrolytes in lithium batteries were studied. The self-diffusion coefficients of the corresponding pure solvents were also measured. Since a good correlation between the self-diffusion coefficients of the pure solvents and the inverse of the viscosity was obtained, the results are discussed in terms of the Stokes-Einstein equation. Comparisons of the self-diffusion coefficients of the solvent, the lithium ion, and the anion (TFSI ion) illustrate the solvation behavior for each solvent. The relationship between the ionic conductivity and the sum of the diffusion coefficients of the lithium ion and the anion gives the degree of ion-pair formation and permits the roles of the solvents in the electrolytes to be clearly explained.
The Internet IP Security Domain of Interpretation for ISAKMP (1998)

Section 4.4.4.2 states, "All implememtations within the IPSEC DOI MUST support ESP_DES...". Recent work in the area of cryptanalysis suggests that DES may not be sufficiently strong for many applications. Therefore, it is very likely that the IETF will deprecate the use of ESP_DES as a mandatory cipher suite in the near future. It will remain as an optional use protocol. Although the IPsec working group and the IETF in general have not settled on an alternative algorithm (taking into account concerns of security and performance), implementers may want to heed the recommendations of section 4.4.4.3 on the use of ESP_3DES.
Late onset variants in Fabry disease: Results in high risk population screenings in Argentina (2015)

Screening programs for FD in high risk populations are important as FD is a treatable multisystemic disease which is frequently overlooked in patients who present without classical manifestations.
Evanescent‐wave scattering in near‐field optical microscopy (1999)

Extended Mie theory is used to investigate the scattering and extinction of evanescent waves by small spherical particles and aggregates of such particles. Metallic, dielectric and metal-coated dielectric particles are taken into consideration. In contrast to plane-wave excitation, p- and s-polarized spectra differ in the case of evanescent waves due to the inherent asymmetry of both polarizations. Furthermore, contributions from higher multipoles are strongly enhanced, compared with plane-wave excitation, and the enhancement factors are polarization dependent. The corresponding changes in the scattering and extinction spectra are most pronounced in cases where higher multipoles exhibit resonances in the spectral range considered. This applies, for example, to morphological resonances of dielectric particles with size parameters > 1. The effect of the surface, where the evanescent wave is generated by total internal reflection, on the scattering and extinction spectra is investigated via numerical field calculations employing the multiple multipole method. In an application to apertureless near-field optical microscopy, the variation of the scattered power is calculated when a silicon particle is scanned across a silver particle in the evanescent field.
Clostridium perfringens enterotoxin is a superantigen reactive with human T cell receptors V beta 6.9 and V beta 22. (1992)

Candidate superantigens were screened for their ability to induce lysis of human histocompatibility leukocyte antigen class II-positive targets by human CD8+ influenza-specific cytotoxic T cell (CTL) lines. Clostridium perfringens enterotoxin (CPET) induced major histocompatibility complex unrestricted killing by some but not all CTL lines. Using "anchored" polymerase chain reactions, CPET was shown to selectively stimulate peripheral blood lymphocytes bearing T cell receptor V beta 6.9 and V beta 22 in five healthy donors. V beta 24, V beta 21, V beta 18, V beta 5, and V beta 6.1-5 appeared to be weakly stimulated. Antigen processing was not required for CPET to induce proliferation. Like the staphylococcal enterotoxins, CPET is a major cause of food poisoning. These data suggest that superantigenic and enterotoxigenic properties may be closely linked.
DISTRIBUTION OF TYROSINE HYDROXYLASE IN HUMAN AND ANIMAL BRAIN1 (1971)

Abstract The activity of tyrosine hydroxylase (EC 1.10.3.1) when assayed under ideal conditions in young human brains, was comparable to that in brains of other species in level of activity and distribution. The highest levels of activity were in the putamen, caudate nucleus and substantia nigra, in keeping with data on other species. The caudate activity in human brain appeared to decrease substantially with increasing age. In both humans and baboons, the enzyme in the neostriatum was particle‐bound and inhibited by the 2‐amino‐4‐hydroxy‐6,7‐dimethyltetrahydropteridine cofactor system. In the substantia nigra it was soluble and stimulated by the 2‐amino‐4‐hydroxy‐6,7‐dimethyltetrahydropteridine cofactor system. The data suggest that tyrosine hydroxylase may be produced in a soluble form in the cell bodies of the substantia nigra but become bound as it moves toward the nerve endings in the putamen and caudate nucleus. The bound form of the enzyme was unstable but the soluble form exhibited considerable stability.
[Rapamycin and CCI-779]. (1999)

Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation of messenger RNA is the main known target of rapamycin. During clinical studies, rapamycin given by oral route as immunosuppressant did not show dose-limited toxicity and only asymptomatic thrombopenia and hyperlipemia were observed. In murine models, best antitumoral activity was observed using parental routes. CCI-779, an analog formulated for intravenous use has antitumor activity without significant immunosuppressive property in mice and is currently in phase I trials in man.
Data-Efficient Image Recognition with Contrastive Predictive Coding (2019)

Human observers can learn to recognize new categories of images from a handful of examples, yet doing so with artificial ones remains an open challenge. We hypothesize that data-efficient recognition is enabled by representations which make the variability in natural signals more predictable. We therefore revisit and improve Contrastive Predictive Coding, an unsupervised objective for learning such representations. This new implementation produces features which support state-of-the-art linear classification accuracy on the ImageNet dataset. When used as input for non-linear classification with deep neural networks, this representation allows us to use 2-5x less labels than classifiers trained directly on image pixels. Finally, this unsupervised representation substantially improves transfer learning to object detection on the PASCAL VOC dataset, surpassing fully supervised pre-trained ImageNet classifiers.
A Wireless Sensor Network for Greenhouse Climate Control (2013)

Using a wireless sensor network, the authors developed an online microclimate monitoring and control system for greenhouses. They field-tested the system in a greenhouse in Punjab, India, evaluating its measurement capabilities and network performance in real time.
Capturing Whole-Genome Characteristics in Short Sequences Using a Naïve Bayesian Classifier (2001)

Bacterial genomes have diverged during evolution, resulting in clearcut differences in their nucleotide composition, such as their GC content. The analysis of complete sequences of bacterial genomes also reveals the presence of nonrandom sequence variation, manifest in the frequency profile of specific short oligonucleotides. These frequency profiles constitute highly specific genomic signatures. Based on these differences in oligonucleotide frequency between bacterial genomes, we investigated the possibility of predicting the genome of origin for a specific genomic sequence. To this end, we developed a naïve Bayesian classifier and systematically analyzed 28 eubacterial and archaeal genomes. We found that sequences as short as 400 bases could be correctly classified with an accuracy of 85%. We then applied the classifier to the identification of horizontal gene transfer events in whole-genome sequences and demonstrated the validity of our approach by correctly predicting the transfer of both the superoxide dismutase (sodC) and the bioC gene from Haemophilus influenzae to Neisseria meningitis, correctly identifying both the donor and recipient species. We believe that this classification methodology could be a valuable tool in biodiversity studies.
Human immune response against outer membrane proteins of Moraxella (Branhamella) catarrhalis determined by immunoblotting and enzyme immunoassay (1995)

The role of Moraxella (Branhamella) catarrhalis as a respiratory tract pathogen is increasingly recognized. We looked at the human immune response against individual outer membrane proteins of M. catarrhalis and against the 81-kDa CopB protein, which has previously been shown to be a target for protective antibodies. Paired serum samples from six elderly patients with pneumonia were tested by Western blot (immunoblot) analysis by using outer membrane vesicles of M. catarrhalis 035E as antigen. All of the six convalescent-phase serum samples reacted with a protein which migrated at the position of the CopB protein and with a high-molecular-weight protein of M. catarrhalis; three serum samples also reacted with a 34-kDa outer membrane protein. Paired serum samples from 18 patients, 10 of which had M. catarrhalis infection on the basis of previous serology results, were tested by enzyme immunoassay (EIA) with the CopB protein and whole cells of M. catarrhalis 035E as antigens. Nine patients showed a significant rise in EIA titer between acute- and convalescent-phase sera when whole bacterial cells were used as antigens. Six (67%) patient samples that were positive by the EIA with the whole-cell antigen were also positive by the EIA with the CopB antigen, and six of nine patient samples negative by the EIA with the whole-cell antigen were also negative by the EIA with the CopB antigen. These results suggest that both the CopB and a high-molecular-weight protein are major targets of the immune response against M. catarrhalis, and further studies with greater amounts of patient materials are needed to elucidate the usefulness of CopB as an antigen in etiologic studies.
Enabling dynamic composition and coordination for autonomic Grid applications using the Rudder Agent framework (2006)

This paper introduces Rudder, a peer-to-peer agent framework for supporting autonomic applications in decentralized distributed environments. The framework provides agents to discover, select, and compose elements, and defines agent interaction and negotiation protocols to enable appropriate application behaviors to be negotiated and enacted dynamically. The implementations of these protocols as well as agent coordination and negotiation activities are supported by Comet, a scalable decentralized coordination substrate. The operation and experimental evaluation of Rudder is presented.
Tuning the Properties of Conjugated Polyelectrolytes through Surfactant Complexation (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTuning the Properties of Conjugated Polyelectrolytes through Surfactant ComplexationLiaohai Chen, Su Xu, Duncan McBranch, and David WhittenView Author Information Bioscience Division and Chemical Science and Technology Division Los Alamos National Laboratory Los Alamos, New Mexico 87545 QTL Biosystems, LLC, Santa Fe, New Mexico 87501 Cite this: J. Am. Chem. Soc. 2000, 122, 38, 9302–9303Publication Date (Web):September 7, 2000Publication History Received10 April 2000Published online7 September 2000Published inissue 1 September 2000https://pubs.acs.org/doi/10.1021/ja001248rhttps://doi.org/10.1021/ja001248rrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views2208Altmetric-Citations245LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Conjugated polymers,Differential thermal analysis,Fluorescence,Polymers,Surfactants Get e-Alerts
Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes (2000)

We conclude that cell-mediated immune responses induced by accessory gene constructs from clade B may have a broader recognition of divergent HIV-1 viruses and should be further examined for both prophylactic and therapeutic vaccination schemes against HIV-1.
Purification and properties of NADH-ferredoxinTOL reductase. A component of toluene dioxygenase from Pseudomonas putida. (1981)

Cells of Pseudomonas putida, after growth with toluene, contain a multicomponent enzyme system that oxidizes toluene to (+)-1(S),2(R)-dihydroxy-3-methyl-cyclohexa-3,5-diene. One of these components has been purified to homogeneity and shown to be a flavoprotein that contains FAD as the only detectable prosthetic group. Fad was removed from the enzyme during purification. However, equilibrium dialysis experiments showed that the enzyme can bind one mol of FAD/mol of enzyme protein. The apparent molecular weight of the enzyme is 46,000, as judged by gel filtration and polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and mercaptoethanol. The latter result suggests the presence of a single polypeptide chain. The amino acid composition of the enzyme reveals a relatively high content of the hydrophobic amino acids leucine, isoleucine, and valine and is remarkably similar in composition to the flavoproteins that function in certain monooxygenase enzyme systems. The purified enzyme catalyzes the reduction of dichloroindophenol, nitrobluetetrazolium, ferricyanide, and ferredoxinTOL. Its ability to reduce cytochrome c and to function in the toluene dioxygenase enzyme system is absolutely dependent on the presence of ferredoxinTOL.
Incorporation of Chemoselective Functionalities into Peptoids via Solid-Phase Submonomer Synthesis (2004)

A simple route to the introduction of a number of chemoselective functional groups into peptoids (oligo(N-substituted glycines)) by an extension of the standard solid-phase submonomer method is reported. The following groups were introduced: aminooxyacetamide, N-(carbamoylmethyl)acetohydrazide, mercaptoacetamide, 2-pyridinesulfenylmercaptoacetamide, and aldehyde-terminated peptoids. The method uses commercially available reagents, is fully compatible with standard peptoid submonomer synthesis conditions, is easily automated, and generates the desired functionalized peptoid in high yield and purity. Peptoids with suitable pairs of chemoselective ligation groups were joined in high yield.
Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease (2004)

The optimal stimulation site in subthalamic deep brain stimulation (STN-DBS) was evaluated by correlation of the stereotactic position of the stimulation electrode with the electrophysiologically specified dorsal STN border. In a series of 25 electrodes, best clinical results with least energy consumption were found in contacts located in the dorsolateral border zone, whereas contacts within the subthalamic white matter, e.g., zona incerta, were significantly less effective. We suggest that the dorsolateral STN border should be covered by STN-DBS.