gebhart/patrepeval huggingface dataset:
Comparison in the Coating of Mg(OH) 2 on Micron‐Sized and Nanometer‐Sized Nb 2 O 5 Particles (2004)

Using Mg(OH) 2 coating on Nb 2 O 5 particles as a model system, the effects of core particle size and that of aging on coating in an aqueous environment were investigated. Specifically, two Nb 2 O 5 particle sizes were used in this study: micron‐sized commercial Nb 2 O 5 powder and 17‐nm synthesized Nb 2 O 5 particles. Coating of Mg(OH) 2 on Nb 2 O 5 was carried out by precipitating Mg(OH) 2 from magnesium nitrate in an aqueous Nb 2 O 5 suspension. The coating behavior of Mg(OH) 2 on Nb 2 O 5 was examined with optical microscopy, zeta‐potential measurement, and local chemical analysis by energy dispersion spectroscopy (EDS). The results showed that the size of Nb 2 O 5 plays an important role in the coating behavior of Mg(OH)2. Optical micrographs, zeta‐potential measurements, as well as local EDS analysis all indicated that coating Mg(OH) 2 on micron‐sized Nb 2 O 5 particles was easier than on nanometer‐sized Nb 2 O 5 particles. We attribute the difficulty in coating Mg(OH) 2 on nanometer‐sized Nb 2 O 5 to the enhanced dissolution of Mg(OH) 2 by the nanometer particle size as a result of the Kelvin effect. Aging improved the coating on micron‐sized Nb 2 O 5 but did not exhibit significant improvement in the Mg(OH) 2 coating on nanometer‐sized Nb 2 O 5 particles. It is likely that aging modified the coating behavior of Mg(OH) 2 on Nb 2 O 5 via a dissolution‐re‐precipitation mechanism.
Chronic Myeloid Leukemia (CML) Treatment in Brazil: Results of the Rio Grande do Sul Cooperative Group for Treatment of CML. (2006)

Abstract Background: Imatinib mesylate (Glivec,Novartis), an inhibitor of Bcr-abl tyrosine kinase, is currently being used in the treatment of CML with hematological, cytogenetic and molecular response. In Brazil, this drug is approved by Health Department for chronic phase (CP) as a second line drug and as first line for accelerated (AP) and blastic phase (BP). Rio Grande do Sul (RS) Cooperative Group for Treatment of CML coordinates the treatment of this disease in Rio Grande do Sul, the southern most state of Brazil that differs from the north part of the country regarding climate, population profile (mostly European descendents) and a high number of farm workers. Methods: 211 CML Ph+ patients are presently being treated in RS. Sex distribution: 96 male and 115 females, aged 11–80 years (median 48 y);166/211 in CP, 42/211 in AP and 11/211 in BP. Imatinib daily dose is 400 mg (CP) and 600 mg (AP and BP). 166/211 patients are in treatment with imatinib and 32/211, interferon or hydroxyureia. In imatinib group, 144/166 patients are in complete hematologic response and 57/166 in complete cytogenetic remission. Conclusions: in Brazil, imatinib treatment is limited by economic problems and the drug is used latter in course of disease. This may compromise the results, as seen in the low cytogenetic complete response described above. We are now investigating this results in order tofind other related factors.
Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta (1-6) glucosamine disaccharide 1,4'-bisphosphate (1986)

A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e., (R)-3-hexadecanoyloxytetradecanoyl, (R)-3-hydroxytetradecanoyl, (R)-3-dodecanoyloxytetradecanoyl, and (R)-3-tetradecanoyloxytetradecanoyl groups at the 2-amino, 3-hydroxyl, 2'-amino, and 3'-hydroxyl groups, respectively, was less biologically active than the synthetic Escherichia coli-type lipid A (compound 506), which has only two acyloxyacyl groups at the 2' and 3' positions and is substituted with a (R)-3-hydroxytetradecanoyl group at the 2-amino group. Compound 516 exhibited considerably weaker pyrogenic and leukopenic activity than compound 506, and it scarcely prepared rabbit skin for the Shwartzman reaction and lacked lethal toxicity on chicken embryos, although its lethal toxicity in galactosamine-loaded mice was as strong as that of compound 506. Compound 516 was also less active than compound 506 or natural E. coli lipid A (from Restrain F515) in other biological test systems, such as the Limulus test, stimulation of macrophages and lymphocytes, and interferon-inducing activity but not for interleukin-1 induction or complement activation. This observation suggests that there is an optimal number of acyloxyacyl groups on the glucosamine backbone for producing the biological activities of lipid A, especially the endotoxic activities. The 4'-monophosphate analog (compound 514) of compound 516 in general had significantly weaker activity than compound 516 in the above assays, most probably because of its greater hydrophobicity and consequently lower solubility in assay systems. Bacterial R595 lipid A derived from S. minnesota Re-mutant, which is a mixture of compounds 516 and 506, their 4'-monophosphate analogs and other compounds, exerted intermediate degrees of activity between compounds 506 and 516 in the various test systems employed.
Clustering Concept Hierarchies from Text (2004)

We present a novel approach to learning taxonomies or concept hierarchies from text.The approach is based on Formal Concept Analysis, a method mainly used for the analysis of data, i.e. for investigating and processing explicitly given information.Our approach is based on the distributional hypothesis, i.e. that nouns or terms are similar to the extent to which they share contexts.Further, we assume that verbs pose more or less strong selectional restrictions on their arguments.The concept hierarchy is built via Formal Concept Analysis using syntactic dependencies as attributes.The approach is evaluated by comparing the produced concept hierarchies against two handcrafted taxonomies from two different domains: tourism and finance.We compare the results of our approach against a hierarchical bottom-up clustering algorithm as well as against Bi-Section-Kmeans as an instance of a top-down clustering algorithm.
Glycoproteins and Their Relationship to Human Disease (1998)

Glycoproteins are proteins that carry N- and O-glycosidically-linked carbohydrate chains of complex structures and functions. N-glycan chains are assembled in the endoplasmic reticulum and the Golgi by a controlled sequence of glycosyltransferase and glycosidase processing reactions involving dolichol intermediates. The assembly of O-glycans occurs in the Golgi and does not involve dolichol. For most reactions, families of glycosyltransferases exist; the expression of the individual enzymes within a family is often subject to complex regulation. The biosynthesis of N- and O-glycan is controlled at the level of gene expression, mRNA, enzyme protein activity and localization, and through substrate and cofactor concentrations at the site of synthesis. This complex regulation results in many hundreds of structures, the range of which varies in different species, cell types, tissue types, states of development and differentiation. In diseased cells, the relative proportions of these structures are often characteristically different from normal, and may be useful for the assessment of the stage of the disease and for diagnosis. Knowledge of disease-specific glycoprotein structures and their functions may be used therapeutically, in immunotherapy, in blocking cell adhesion or interfering with other binding or biological processes. Recently, some of the mechanisms underlying glycoprotein alterations in disease have been elucidated. This opens the possibility of an active interference in the disease process. The functions of glycans in diseased cells will become more clear with the tools of molecular biology and transgenic animal models.
Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16 (1997)

Adenovirus internalization generally has been accepted to involve an interaction of the adenoviral penton base protein with alpha(v)beta3 and alpha(v)beta5 cell surface integrins. In this study we show that exposure of a panel of melanoma cells to the beta1-activating antibody TS2/16 rendered such cells more susceptible to adenovirus infection. This increase in adenoviral infectivity paralleled effects on cell adhesion, and both these characteristics were mediated, in part, by the alpha5beta1 integrin. These observations suggest that alpha5beta1 may act as an alternative adenovirus receptor and that integrin-activating strategies may improve the efficacy of recombinant adenoviruses as vectors for gene therapy.
Run-time methods for parallelizing partially parallel loops (1995)

In this paper we give a new run-time technique for finding an optimal parallel execution schedule for a partially parallel loop, i.e., a loop whose parallelization requires synchronization to ensure that the iterations are executed in the correct order. Given the original loop, the compiler generates inspector code that performs run-time preprocessing of the loop's access pattern, and scheduler code that schedules (and executes) the loop iterations. The inspector is fully parallel, uses no synchronization, and can be applied to any loop. In addition, it can implement at run-time the two most effective transformations for increasing the amount of parallelism in a loop: array privatization and reduction parallelizatiort (element-wise).
Precise indoor localization using PHY layer information (2011)

This paper shows the viability of precise indoor localization using physical layer information in WiFi systems. We find that channel frequency responses across multiple OFDM sub-carriers can be suitably aggregated into a location fingerprint. While these fingerprints vary over time and environmental mobility, we notice that their core structure preserves certain properties that are amenable to localization. We demonstrate these ideas through a functional prototype, implemented on off-the-shelf Intel 5300 cards (that export per-subcarrier information to the driver). We evaluate the prototype using the existing APs inside a busy building, a cafeteria, and a museum, and demonstrate localization accuracies in the granularity of 1m × 1m boxes, called spots. Results show that our system, PinLoc, is able to localize users to a spot with 90% mean accuracy, while incurring less than 6% false positives. We believe this holds promise towards an important development in indoor localization.
Antioxidant and pro-oxidant assay for a new drug GEPC: detected by ESR spectrometry and by protective effects on lipid peroxidation and biomolecule degradation. (1993)

L-Ascorbic acid 2-(20 beta-11-oxo-olean-12-en-29-oic acid ethylester-3-beta-yl hydrogen phosphate) sodium salt (GEPC) is a newly synthesized compound representing a phosphate diester linkage of glycyrrhetic acid ethylester and ascorbic acid. In the present study, we found that GEPC effectively inhibited Fe(III)-ADP/NADPH-induced peroxidation of liver microsomes. The inhibitory effect was much greater than that of glycyrrhetic acid (GA), and contrasted with the stimulatory effect of ascorbic acid. An ESR study showed that GEPC appeared to have a great loss of the DPPH and superoxide radical scavenging effects of ascorbic acid. However, GEPC, like ascorbic acid, inhibited hydroxyl radicals generation in both Fe(II)-H2 O2 and Cr(VI)-H2 O2 systems. GEPC, unlike ascorbic acid, showed no pro-oxidant effect and acted as an effective iron-chelating agent in the ESR study or in the iron-induced deoxyribose and DNA degradation assays. The hydroxyl radical scavenging effect of GEPC was further demonstrated by its protective effect on the hydroxyl radical- induced degradation of certain biomolecules, i.e., carbohydrates, amino acids, and DNA. These results demonstrate that beside its protective effect on ascorbic acid autoxidation and increasing water solubility of GA, GEPC is also an antioxidant though not so powerful as ascorbic acid but more powerful than GA.
Programming Contests (1988)

Since 1983, elementary and secondary students in Kentucky have been participating in an annual computer programming contest sponsored by the University of Wisconsin-Parkside. Each year data have been gathered focusing on three main categories: type of training and exposure to computers (most participants had studied BASIC in a programming class at their schools), gender differences related to computer use (males had been programming for a longer period of time and spend more time per week working at a computer than females), and factors related to contest scores (gender was not a significant factor; other factors varied over the years). This article compares the findings over the three years and poses questions resulting from these findings.
State of the Art and Perspectives on Silicon Photonic Switches (2019)

In the last decade, silicon photonic switches are increasingly believed to be potential candidates for replacing the electrical switches in the applications of telecommunication networks, data center and high-throughput computing, due to their low power consumption (Picojoules per bit), large bandwidth (Terabits per second) and high-level integration (Square millimeters per port). This review paper focuses on the state of the art and our perspectives on silicon photonic switching technologies. It starts with a review of three types of fundamental switch engines, i.e., Mach-Zehnder interferometer, micro-ring resonator and micro-electro-mechanical-system actuated waveguide coupler. The working mechanisms are introduced and the key specifications such as insertion loss, crosstalk, switching time, footprint and power consumption are evaluated. Then it is followed by the discussion on the prototype of large-scale silicon photonic fabrics, which are based on the configuration of above-mentioned switch engines. In addition, the key technologies, such as topological architecture, passive components and optoelectronic packaging, to improve the overall performance are summarized. Finally, the critical challenges that might hamper the silicon photonic switching technologies transferring from proof-of-concept in lab to commercialization are also discussed.
Molecular Basis for Estrogen Receptor Deficiency in BRCA1-Linked Breast Cancer (2007)

BRCA1 alters the response of breast cancer cells to antiestrogen therapy by directly modulating ER alpha expression.
Clostridium difficile (2013)

Biological therapies for CDI, especially FMT, will continue to attract attention. Further, large-scale RCTs are required to identify which patients are most likely to benefit from these therapies in the future.
Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides via tert-Butyl Isocyanide Insertion (2013)

A simple and efficient palladium-catalyzed carbonylative Sonogashira coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of alkynyl imines which can undergo simple silica gel catalyzed hydrolysis to afford alkynones. The approach is tolerant of a wide range of substrates and applicable to library synthesis.
Colloidal Suspensions of Highly Reduced Graphene Oxide in a Wide Variety of Organic Solvents (2009)

We report that homogeneous colloidal suspensions of chemically modified graphene sheets were readily produced in a wide variety of organic solvent systems. Two different sets of solubility parameters are used to rationalize when stable colloidal suspensions of graphene oxide sheets and, separately, of reduced graphene oxide sheets in a given solvent type are possible and when they are not. As an example of the utility of such colloidal suspensions, "paperlike" materials generated by very simple filtration of the reduced graphene oxide sheets had electrical conductivity values as high as 16,000 S/m.
Cross-Validation of Regression Models (1984)

Abstract A methodolgy for assessment of the predictive ability of regression models is presented. Attention is given to models obtained via subset selection procedures, which are extremely difficult to evaluate by standard techniques. Cross-validatory assessments of predictive ability are obtained and their use illustrated in examples.
Inflammatory Mediators in Gastrointestinal Defense and Injury (1997)

Irrespective of where ulceration occurs in the gastrointestinal tract, it is almost always associated with mucosal inflammation. The chemical mediators that coordinate inflammatory responses also have the capability to alter the resistance of the mucosa to injury. Some inflammatory mediators increase the resistance of the mucosa to injury, while others exert "ulcerogenic" effects. In this review, we provide an overview of the major inflammatory mediators that have been shown to exert effects on mucosal defense in the gastrointestinal tract. Among the inflammatory mediators discussed are the eicosanoids (prostaglandins, leukotrienes, thromboxanes), nitric oxide, neuropeptides, and cytokines (IL-1beta, TNF alpha). Several of these mediators are considered potential therapeutic targets for the treatment of ulcerative diseases of the digestive system, and, in some cases, clinical data are available on the efficacy of such approaches.
Self-Assembled Nanoparticle Probes for Recognition and Detection of Biomolecules (2002)

Colloidal gold nanocrystals have been used to develop a new class of nanobiosensors that is able to recognize and detect specific DNA sequences and single-base mutations in a homogeneous format. At the core of this biosensor is a 2.5-nm gold nanoparticle that functions as both a nano-scaffold and a nano-quencher (efficient energy acceptor). Attached to this core are oligonucleotide molecules labeled with a thiol group at one end and a fluorophore at the other. This hybrid bio/inorganic construct is found to spontaneously assemble into a constrained arch-like conformation on the particle surface. Binding of target molecules results in a conformational change, which restores the fluorescence of the quenched fluorophore. Unlike conventional molecular beacons with a stem-and-loop structure, the nanoparticle probes do not require a stem, and their background fluorescence increases little with temperature. In comparison with the organic quencher Dabcyl (4,4'-dimethylaminophenyl azo benzoic acid), metal nanoparticles have unique structural and optical properties for new applications in biosensing and molecular engineering.
Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways (2010)

Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity, although at present the underlying mechanisms are unclear. Consistent with previous findings, Sclerostin opposed direct Wnt3a-induced but not direct BMP7-induced responses when both ligand and antagonist were provided exogenously to cells. However, we found that when both proteins are expressed in the same cell, sclerostin can antagonize BMP signaling directly by inhibiting BMP7 secretion. Sclerostin interacts with both the BMP7 mature domain and pro-domain, leading to intracellular retention and proteasomal degradation of BMP7. Analysis of sclerostin knock-out mice revealed an inhibitory action of sclerostin on Wnt signaling in both osteoblasts and osteocytes in cortical and cancellous bones. BMP7 signaling was predominantly inhibited by sclerostin in osteocytes of the calcaneus and the cortical bone of the tibia. Our results suggest that sclerostin exerts its potent bone catabolic effects by antagonizing Wnt signaling in a paracrine and autocrine manner and antagonizing BMP signaling selectively in the osteocytes that synthesize simultaneously both sclerostin and BMP7 proteins.
Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1 (2004)

Neural precursor cells from adults have exceptional proliferative and differentiative capability in vitro yet respond minimally to in vivo brain injury due to constraining mechanisms that are poorly defined. We assessed whether cell cycle inhibitors that restrict stem cell populations in other tissues may participate in limiting neural stem cell reactivity in vivo. The cyclin-dependent kinase inhibitor, p21cip1/waf1 (p21), maintains hematopoietic stem cell quiescence, and we evaluated its role in the regenerative response of neural tissue after ischemic injury using the mice deficient in p21. Although steady-state conditions revealed no increase in primitive cell proliferation in p21-null mice, a significantly larger fraction of quiescent neural precursors was activated in the hippocampus and subventricular zone after brain ischemia. The hippocampal precursors migrated and differentiated into a higher number of neurons after injury. Therefore, p21 is an intrinsic suppressor to neural regeneration after brain injury and may serve as a common molecular regulator restricting proliferation among stem cell pools from distinct tissue types.
Production of autoreactive I region-restricted T cell hybridomas. (1982)

We produced autoreactive T cell hybridomas that can be induced to secrete interleukin 2 by co-culture with either syngeneic splenic stimulator cells or syngeneic Ia-positive B cell-B lymphoma hybridomas. These autoreactive hybridomas arose from the fusion of pork insulin-primed lymph node T cells with the AKR thymoma BW 5147 and occurred at a higher frequency than the expected insulin-specific hybridomas. Mapping studies using recombinant strains and blocking studies using monoclonal anti-Ia antibodies localized the stimulatory determinant to the I-Ad subregion of the major histocompatibility complex. These T cell hybridomas did not appear to be directed at any foreign antigen present in the culture system because activation occurred in serum-free, insulin-free medium (Iscove's medium). Such hybridomas should prove to be a potent tool in studying the biologic significance and function of the autoreactive response.
VAST Challenge 2012: Visual analytics for big data (2012)

The 2012 Visual Analytics Science and Technology (VAST) Challenge posed two challenge problems for participants to solve using a combination of visual analytics software and their own analytic reasoning abilities. Challenge 1 (C1) involved visualizing the network health of the fictitious Bank of Money to provide situation awareness and identify emerging trends that could signify network issues. Challenge 2 (C2) involved identifying the issues of concern within a region of the Bank of Money network experiencing operational difficulties utilizing the provided network logs. Participants were asked to analyze the data and provide solutions and explanations for both challenges. The data sets were downloaded by nearly 1100 people by the close of submissions. The VAST Challenge received 40 submissions with participants from 12 different countries, and 14 awards were given.
Multicomponent Submicron Features of Biomolecules Created by Voltage Controlled Deposition from a Nanopipet (2003)

We have used a nanopipet as a nanopen to locally and controllably deposit complex biomolecules, including antibodies and DNA, onto a surface to create multicomponent and functional submicron features. Key advantages of this method are that the biomolecules are always in solution and the applied voltage provides fine control of the delivery down to the single molecule level. Two consecutive cycles of deposition, to produce spatially varying features with different biological properties, were demonstrated with fluorescently labeled antibodies or biotin. This approach combines "top-down" fabrication, using the nanopen for local application, and "bottom-up" fabrication, using molecular recognition for self-assembly at defined positions, and opens up new possibilities in nanotechnology.