gebhart/patrepeval huggingface dataset:
Metastatic potential of four human melanoma xenografts in young athymic mice following tail vein inoculation. (1987)

We have investigated the lung colonizing ability of four newly established human metastatic melanoma xenografts, designated CRML1, CRML2, CRML3, and CRML4 following i.v. tail vein inoculation into 3- to 4-week-old gnotobiotic CD-1 athymic mice. The experimental metastatic potential of the tumors was assessed from the primary tumor samples through eight progressively growing s.c. passages. CRML1 and 2 were investigated in detail; five sublines (two from CRML1 and three from CRML2) were established from these tumors with various growth rates and lung colonizing abilities. The histopathologies of the patients' biopsies and the s.c. passaged parental lines were compared with these i.v.-derived sublines as one measure of tumor heterogeneity, in conjunction with the kinetics of lung tumor formation. The frequency and distribution of extrapulmonary tumor growth was also investigated after i.v. inoculation. In general, it reflected the clinical distribution of metastases, although their frequency of appearance was reduced. While CRML3 was the most aggressive disease clinically, it did not demonstrate the reproducible experimental metastasis of the other lines. CRML4 produced lung colonies routinely, but with latency periods of 20 weeks or more. On the other hand, the most rapidly growing sublines of CRML1 and CRML2 essentially replaced the normal lung tissue within 4 to 6 weeks following inoculation of 10(5) cells. The two sublines of CRML1 with higher effective metastatic potential were maximally able to colonize the lungs within only two i.v. cycles in one case, while the other line required six i.v. to i.v. passages to reach its maximum ability. In CRML2, two sublines were identified that rapidly increased in their lung colonizing ability, while another line remained effectively equal to the parental s.c. line over four cycles of reinoculation i.v. These results demonstrated that the athymic mouse can serve as a model for experimental metastasis of human tumors, and that aspects of the metastatic heterogeneity of these tumors can be investigated by using this system.
Water vapor permeability and mechanical properties of fabrics coated with shape‐memory polyurethane (2004)

Abstract Water vapor permeable fabrics were prepared by coating shape‐memory polyurethane (PU), which was synthesized from poly(tetramethylene glycol), 4,4′‐methylene bis(phenylisocyanate), and 1,4‐butanediol, onto polyester woven fabrics. Water vapor permeability and mechanical properties were investigated as a function of PU hard‐segment content or polymer concentration of the coating solution. Water vapor permeability of PU‐coated fabrics decreased dramatically with increased concentration of coating solution, whereas only a slight change was observed with the control of PU hard‐segment content. The coated fabric showed the clear appearance of a nonporous PU surface according to SEM measurements. Attainment of high water permeability in PU‐coated fabrics is considered to arise from the smart permeability characteristics of PU. Mechanical properties of coated fabrics, although there was some variation depending on the concentration of coating solution, were primarily affected by PU hard‐segment content. Fabrics coated with PU hard‐segment content of 40% showed the lowest breaking stress and modulus as well as the highest breaking elongation, which could be interpreted in terms of the dependency of mechanical properties of coated fabrics on PU hard‐segment content and the yarn mobility arising from a difference in penetrating degree of coating solution into the fabric. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 2812–2816, 2004
Methylation analysis of CGG sites in the CpG island of the human FMR1 gene (1992)

The fragile-X syndrome of mental retardation is associated with an expansion in the number of CGG repeats present in the FMR1 gene. The repeat region is within sequences characteristic of a CpG island. Methylation of CpG dinucleotides that are 5' to the CGG repeat has been shown to occur on the inactive X chromosome of normal females and on the X chromosome of affected fragile-X males, and is correlated with silencing of the FMR1 gene. The methylation status of CpG sites 3' to the repeat and within the repeat itself has not previously been reported. We have used two methylation-sensitive restriction enzymes, AciI and Fnu4HI, to further characterize the methylation pattern of the FMR1 CpG island in normal individuals and in those carrying fragile-X mutations. Our results indicate that: (i) CpG dinucleotides on the 3' side of the CGG repeat are part of the CpG island that is methylated during inactivation of a normal X chromosome in females; (ii) the CGG repeats are also part of the CpG island and are extensively methylated as a result of normal X-chromosome inactivation; (iii) similar to normal males, unaffected fragile-X males with small CGG expansions are unmethylated in the CpG island; for affected males, the patterns of methylation are similar to those of a normal, inactive X chromosome; (iv) in contrast to the partial methylation observed for certain sites in lymphocyte DNA, complete methylation was observed in DNA from cell lines containing either a normal inactive X chromosome or a fragile-X chromosome from an affected male.(ABSTRACT TRUNCATED AT 250 WORDS)
Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants (2013)

Early plants began colonizing the terrestrial earth approximately 450 million years ago. Their success on land has been partially attributed to the evolution of specialized metabolic systems from core metabolic pathways, the former yielding structurally and functionally diverse chemicals to cope with a myriad of biotic and abiotic ecological pressures. Over the past two decades, functional genomics, primarily focused on flowering plants, has begun cataloging the biosynthetic players underpinning assorted classes of plant specialized metabolites. However, the molecular mechanisms enriching specialized metabolic pathways during land plant evolution remain largely unexplored. Selaginella is an extant lycopodiophyte genus representative of an ancient lineage of tracheophytes. Notably, the lycopodiophytes diverged from euphyllophytes over 400 million years ago. The recent completion of the whole-genome sequence of an extant lycopodiophyte, S. moellendorffii, provides new genomic and biochemical resources for studying metabolic evolution in vascular plants. 400 million years of independent evolution of lycopodiophytes and euphyllophytes resulted in numerous metabolic traits confined to each lineage. Surprisingly, a cadre of specialized metabolites, generally accepted to be restricted to seed plants, have been identified in Selaginella. Initial work suggested that Selaginella lacks obvious catalytic homologs known to be involved in the biosynthesis of well-studied specialized metabolites in seed plants. Therefore, these initial functional analyses suggest that the same chemical phenotypes arose independently more commonly than anticipated from our conventional understanding of the evolution of metabolism. Notably, the emergence of analogous and homologous catalytic machineries through convergent and parallel evolution, respectively, seems to have occurred repeatedly in different plant lineages.
Concurrent Tandem Catalysis (2005)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcurrent Tandem CatalysisJulia-Christina Wasilke, Stephen J. Obrey, R. Tom Baker, and Guillermo C. BazanView Author Information Department of Chemistry and Biochemistry, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, and Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Cite this: Chem. Rev. 2005, 105, 3, 1001–1020Publication Date (Web):February 19, 2005Publication History Received12 August 2004Published online19 February 2005Published inissue 1 March 2005https://pubs.acs.org/doi/10.1021/cr020018nhttps://doi.org/10.1021/cr020018nresearch-articleACS PublicationsCopyright © 2005 American Chemical SocietyRequest reuse permissionsArticle Views13942Altmetric-Citations1337LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysis,Catalysts,Chemical reactions,Hydrocarbons,Polymers Get e-Alerts
Modeling shape and textural variations in aging faces (2008)

We propose a two fold approach towards modeling facial aging in adults. Firstly, we develop a shape transformation model that is formulated as a physically-based parametric muscle model that captures the subtle deformations facial features undergo with age. The model implicitly accounts for the physical properties and geometric orientations of the individual facial muscles. Next, we develop an image gradient based texture transformation function that characterizes facial wrinkles and other skin artifacts often observed during different ages. Facial growth statistics (both in terms of shape and texture) play a crucial role in developing the aforementioned transformation models. From a database that comprises of pairs of age separated face images of many individuals, we extract age-based facial measurements across key fiducial features and further, study textural variations across ages. We present experimental results that illustrate the applications of the proposed facial aging model in tasks such as face recognition and facial appearance prediction across aging.
Graphene–assisted critically–coupled optical ring modulator (2012)

Graphene's conductivity at optical frequencies can be varied upon injection of carriers. In the present paper, this effect is used to modulate losses of an optical wave traveling inside a ring cavity. This way an optical modulator based on the critical-coupling concept first introduced by Yariv can be realized. Through numerical simulations, we show that a modulator featuring a bandwidth as large as 100 GHz can be designed with switching energy in the order of few fJ per bit. Also, we show that operations with driving voltages below 1.2 volt could be obtained, thus making the proposed modulator compatible with requirements of low-voltage CMOS technology.
Murine Models ofChlamydia pneumoniaeInfection and Atherosclerosis (1997)

Chlamydia pneumoniae have been demonstrated in atherosclerotic lesions but not in normal arteries. An animal model of both C. pneumoniae and atherosclerosis is needed to investigate the role of the organism in atherosclerosis. Apolipoprotein (apo) E-deficient transgenic mice, which spontaneously develop atherosclerosis, and C57BL/6J mice, which only develop atherosclerosis on an atherogenic diet, were evaluated. Following single and multiple intranasal inoculations of apoE-deficient transgenic mice, C. pneumoniae were detected in lung, aorta, and spleen for 20 weeks after inoculation in 25%-100% of mice. In the aorta, C. pneumoniae were detected within the atherosclerotic lesion. In C57BL/6J mice on a nonatherogenic diet, C. pneumoniae were detected in the aorta only 2 weeks after a single intranasal inoculation in 8% of mice. The persistence of C. pneumoniae in atheromas suggests a tropism of C. pneumoniae to the lesion. These mouse models should be useful for studying the pathogenic role of C. pneumoniae in atherosclerosis.
Protein Microdeposition Using a Conventional Ink-Jet Printer (2000)

Many recent bioanalytical systems based on immunologic and hybridization reactions in a mono- or bidimensional microarray format require technology that can produce arrays of spots containing biospecific molecules. Some microarray deposition instruments are commercially available, and other devices have been described in recent papers. We describe a system obtained by adapting a commercial ink-jet printer and used to produce mono- and bidimensional arrays of spots containing horseradish peroxidase on cellulose paper. In a few minutes, it was possible to obtain bidimensional arrays containing several thousands of spots with a diameter as low as 0.2 mm, with each of which requiring only a few nanoliters of the enzyme deposition solution. The quantity of enzyme in each spot was evaluated with a chemiluminescent reaction and a charge-coupled device-based, low-light imaging luminograph. The chemiluminescence measurements revealed that the reproducibility of the enzyme deposition was satisfactory for analytical purposes, with the variation coefficients being lower than 10% in almost all cases.
Knitted polypropylene (Marlex) mesh in the repair of incisional hernias. (1984)

In 50 consecutive patients, large incisional hernias or those difficult to manage were repaired by suture imbrication of the hernial sac and extrafascial onlay fixation of Marlex mesh. Seromas developed in three and wound infection in two. The use of closed suction drains for all patients and antibiotic prophylaxis before and after operation for patients with antecedent wound infections may prevent these complications. In the follow-up period (mean of 2.6 years), lateral recurrence of the hernias occurred in three patients, but there has been no recurrence in the last 2 years. The method of repair is simple and effective.
The incidence of herpes zoster (1995)

<h3>Background:</h3> There are few population-based studies of the natural history and epidemiology of herpes zoster. Although a relatively common cause of morbidity, especially among the elderly, contemporary estimates of herpes zoster incidence are lacking. Herein we describe a population-based investigation of incident and recurrent herpes zoster from 1990 through 1992 in a health maintenance organization. <h3>Methods:</h3> The health maintenance organization's automated medical records contain clinical and administrative information about care rendered to patients in ambulatory settings, emergency departments, and hospitals. Cases of herpes zoster were ascertained by screening the medical record for coded diagnoses. The predictive value of a herpes zoster diagnosis code was determined by review of a sample of patient records. Records from all patients with potential recurrences were also reviewed. <h3>Results:</h3> The overall incidence, based on 1075 cases in 500 408 person-years, was 215 per 100 000 person-years (95% confidence interval, 192 to 240 per 100 000) and did not vary by gender. Although the rate increased sharply with age, approximately 5% of the cases occurred among children younger than 15 years. Infection with human immunodeficiency virus was documented in 5% of the persons with incident herpes zoster and cancer in 6%. Four persons had confirmed recurrences of herpes zoster (744 per 100 000 person-years; 95% confidence interval, 203 to 1907); three of these persons were infected with the human immunodeficiency virus. <h3>Conclusions:</h3> The recorded incidence of herpes zoster was 64% higher than that reported 30 years ago; the age-standardized rate was more than twofold higher. Immunosuppressive conditions had little impact on overall incidence, although they were strongly associated with early recurrences. (Arch Intern Med. 1995;155:1605-1609)
Environmental conditions which influence mucoid conversion Pseudomonas aeruginosa PAO1 (1991)

Growth and conversion to the mucoid phenotype by nonmucoid Pseudomonas aeruginosa PAO1 was studied in a chemostat system under conditions designed to reflect those likely to be present during chronic infection in the lung in cystic fibrosis patients. Mucoid variants were consistently isolated during continuous culture in the presence of 0.3 M NaCl or 5 or 10% glycerol. Mucoid subpopulations were also detected under conditions of carbon, nitrogen, or phosphate limitation. During carbon or nitrogen limitation, mucoid conversion was dependent upon the choice of substrate. Phosphate-limited cultures exhibited an inverse relationship between culture growth rate and number of mucoid organisms detected. Mucoid variants were not detected when dilution rates (D) exceeded 0.173 h-1. Conversely, at a D of 0.044 h-1, 40% of the population expressed the mucoid phenotype. Phosphorylcholine, a product of phospholipase C activity on the major lung surfactant phosphatidylcholine, was also used as a growth substrate in nutrient limitation studies. Under all conditions, growth of PAO1 supplied with phosphorylcholine resulted in isolation of mucoid variants, indicating that the lung may provide at least one nutrient source conducive to mucoid conversion. Continuous culture also resulted in detection of a phage associated with strain PAO1. High titers of phage were present under all conditions, including those which yielded no mucoid organisms, suggesting that environmental conditions rather than the phage regulated the appearance of mucoid variants.
A novel resource allocation strategy for distributed MIMO multi-hop multi-commodity communications (2008)

In this paper, we present a near-optimum resource allocation strategy for distributed multiple-input-multiple-output multiple hops multiple commodities OFDMA wireless networks. The novel per-hop-optimization strategy aims to reduce the total transmission power of the network while meeting the individual end-to-end outage probability constraint of each commodity, i.e. for each link of the network. It utilizes the Greedy edge-coloring algorithm to determine reused orthogonal subbands for overlapping hops and allows a distributed implementation per hop. In comparison to other bandwidth allocation strategies like equal or dynamic bandwidth for each commodity, our per-hop-bandwidth-allocation (PHBA) approach uses the bandwidth in a near-optimum way and reduces the total transmission power significantly.
Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease (2010)

The autoimmune enteropathy, coeliac disease (CD), is triggered by ingestion of gluten-containing grains. We recently reported that the chemokine receptor CXCR3 serves as a receptor for specific gliadin peptides that cause zonulin release and subsequent increase in intestinal permeability. To explore the role of CXCR3 in the immune response to gliadin, peripheral blood mononuclear cells from both patients with CD and healthy controls were incubated with either pepsin-trypsin-digested gliadin or 11 α-gliadin synthetic peptides in the presence or absence of a blocking anti-CXCR3 monoclonal antibody. Supernatants were analysed for interleukin-6 (IL-6), IL-8, IL-10, IL-13, IP-10 (CXCL10), tumour necrosis factor-α and interferon-γ. Gliadin broadly induced cytokine production irrespective of the clinical condition. However, IL-8 production occurred only in a subgroup of individuals and cells of the phagocytic lineage were the main source. Induction of IL-8 was reproduced by one of a comprehensive panel of synthetic α-gliadin peptides and was abrogated when CXCR3 was blocked before stimulation with either gliadin or this peptide in the CD group but not in the control group, suggesting that gliadin-induced IL-8 production was CXCR3-dependent gliadin induced IL-8 production only in CD.
Point-to-Point Positioning of Flexible Structures using a Time Domain LQ Smoothness Constraint (1991)

An analytical procedure to implement optimal smoothing of the finite-time control waveform for point-to-point control problem is presented, which minimizes an Optimality constraint consisting of a linear combination of the quadratic norms of its time derivatives. It is shown that the resulting control input is essentially the minimum norm solution augmented to satisfy some additional continuity requirements in the time domain. Application of the proposed technique to finite-time maneuvering of flexible structure is experimentally demonstrated and performances are compared using control torques evaluated based on different orders of the smoothness constraint and those of the truncated plant model.
New tight frames of curvelets and optimal representations of objects with piecewise C2 singularities (2003)

Abstract This paper introduces new tight frames of curvelets to address the problem of finding optimally sparse representations of objects with discontinuities along piecewise C 2 edges. Conceptually, the curvelet transform is a multiscale pyramid with many directions and positions at each length scale, and needle‐shaped elements at fine scales. These elements have many useful geometric multiscale features that set them apart from classical multiscale representations such as wavelets. For instance, curvelets obey a parabolic scaling relation which says that at scale 2 − j , each element has an envelope that is aligned along a “ridge” of length 2 − j /2 and width 2 − j . We prove that curvelets provide an essentially optimal representation of typical objects f that are C 2 except for discontinuities along piecewise C 2 curves. Such representations are nearly as sparse as if f were not singular and turn out to be far more sparse than the wavelet decomposition of the object. For instance, the n ‐term partial reconstruction f obtained by selecting the n largest terms in the curvelet series obeys This rate of convergence holds uniformly over a class of functions that are C 2 except for discontinuities along piecewise C 2 curves and is essentially optimal. In comparison, the squared error of n ‐term wavelet approximations only converges as n −1 as n → ∞, which is considerably worse than the optimal behavior. © 2003 Wiley Periodicals, Inc.
Proteomics Reveal Cochlin Deposits Associated with Glaucomatous Trabecular Meshwork (2004)

The etiology of primary open angle glaucoma, a leading cause of age-related blindness, remains poorly defined, although elevated intraocular pressure (IOP) contributes to the disease progression. To better understand the mechanisms causing elevated IOP from aqueous humor circulation, we pursued proteomic analyses of trabecular meshwork (TM) from glaucoma and age-matched control donors. These analyses demonstrated that Cochlin, a protein associated with deafness disorder DFNA9, is present in glaucomatous but absent in normal TM. Cochlin was also detected in TM from the glaucomatous DBA/2J mouse preceding elevated IOP but found to be absent in three other mouse lines that do not develop elevated IOP. Histochemical analyses revealed co-deposits of Cochlin and mucopolysaccharide in human TM around Schlemm's canal, similar to that observed in the cochlea in DFNA9 deafness. Purified Cochlin was found to aggregate after sheer stress and to induce the aggregation of TM cells in vitro. Age-dependent in vivo increases in Cochlin were observed in glaucomatous TM, concomitant with a decrease in type II collagen, suggesting that Cochlin may disrupt the TM architecture and render components like collagen more susceptible to degradation and collapse. Overall, these observations suggest that Cochlin contributes to elevated IOP in primary open angle glaucoma through altered interactions within the TM extracellular matrix, resulting in cell aggregation, mucopolysaccharide deposition, and significant obstruction of the aqueous humor circulation.