gebhart/patrepeval huggingface dataset:
Inhibition of Cancer Cell Growth by Exposure to a Specific Time-Varying Electromagnetic Field Involves T-Type Calcium Channels (2015)

Electromagnetic field (EMF) exposures affect many biological systems. The reproducibility of these effects is related to the intensity, duration, frequency, and pattern of the EMF. We have shown that exposure to a specific time-varying EMF can inhibit the growth of malignant cells. Thomas-EMF is a low-intensity, frequency-modulated (25-6 Hz) EMF pattern. Daily, 1 h, exposures to Thomas-EMF inhibited the growth of malignant cell lines including B16-BL6, MDA-MB-231, MCF-7, and HeLa cells but did not affect the growth of non-malignant cells. Thomas-EMF also inhibited B16-BL6 cell proliferation in vivo. B16-BL6 cells implanted in syngeneic C57b mice and exposed daily to Thomas-EMF produced smaller tumours than in sham-treated controls. In vitro studies showed that exposure of malignant cells to Thomas-EMF for > 15 min promoted Ca(2+) influx which could be blocked by inhibitors of voltage-gated T-type Ca(2+) channels. Blocking Ca(2+) uptake also blocked Thomas-EMF-dependent inhibition of cell proliferation. Exposure to Thomas-EMF delayed cell cycle progression and altered cyclin expression consistent with the decrease in cell proliferation. Non-malignant cells did not show any EMF-dependent changes in Ca(2+) influx or cell growth. These data confirm that exposure to a specific EMF pattern can affect cellular processes and that exposure to Thomas-EMF may provide a potential anti-cancer therapy.
Knockdown ofIG20Gene Expression Renders Thyroid Cancer Cells Susceptible to Apoptosis (2009)

IG20 knockdown renders WRO cells more susceptible to spontaneous, TRAIL-, and TNFalpha-induced apoptosis and thus demonstrates the prosurvival function of the IG20 gene in thyroid cancer. These observations, combined with overexpression of IG20 noted in thyroid tumor tissues, may suggest a potential role in thyroid cancer survival and growth and indicate that IG20 may be targeted either alone or in conjunction with TRAIL or TNFalpha treatment in certain thyroid cancers.
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation (2012)

Despite improvements in first-line therapies, published results on the treatment of relapsed adult acute lymphoblastic leukemia (ALL) show that prognosis is still poor. The aim of the present retrospective analysis of the German Multicenter Study Group for Adult ALL was to identify prognostic factors and options for improvement. A total of 547 patients with a median age of 33 years (range, 15-55) experiencing their first relapse (406 vs 141 shorter or longer than 18 months from diagnosis) were evaluated. The aim of salvage therapy was to achieve a complete remission (CR) with subsequent a stem cell transplantation (SCT). The CR rate (assessed in Philadelphia chromosome- and BCR-ABL-negative ALL without CNS involvement) after the first salvage in relapse after chemotherapy (n = 224) was 42%. After failure of first salvage (n = 82), the CR rate after second salvage was 33%. In relapse after SCT (n = 48) the CR rate after first salvage was 23%. The median overall survival after relapse was 8.4 months and survival was 24% at 3 years. Prognostic factors for survival were relapse localization, response to salvage, performance of SCT, and age. Overall survival appeared superior compared with previously published studies, likely because of the high rate of SCT in the present study (75%). Further improvement may be achieved with earlier relapse detection and experimental approaches in early relapse.
Left‐right asymmetry in gut development: what happens next? (2009)

The gastrointestinal tract is an asymmetrically patterned organ system. The signals which initiate left-right asymmetry in the developing embryo have been extensively studied, but the downstream steps required to confer asymmetric morphogenesis on the gut organ primordia are less well understood. In this paper we outline key findings on the tissue mechanics underlying gut asymmetry, across a range of species, and use these to synthesise a conserved model for asymmetric gut morphogenesis. We also discuss the importance of correct establishment of left-right asymmetry for gut development and the consequences of perturbations in this process.
Expression ofSSX genes in human tumors (1998)

The HOM-MEL-40 antigen which is encoded by the SSX-2 gene was originally detected as a tumor antigen recognized by autologous IgG antibodies in a melanoma patient. Expression analysis demonstrated that SSX-2 is a member of the recently described cancer/testis antigen (CTA) class as it is expressed in a variety of different human neoplasms, but not in normal tissues with the exception of testis and a weak expression in the thyroid. Further studies demonstrated that SSX-2 belongs to a gene family consisting of at least 5 homologous genes. We now report the analysis of the expression of all 5 SSX genes in 325 specimens of human neoplasms from various histological origins, using reverse transcription polymerase chain reaction (RT-PCR). SSX-1, -2, and -4 were found to be expressed in 8%, 15% and 15%, of the tumors, respectively, while the expression of the SSX-5 gene was rare (7/325), and SSX-3 expression was not detected. For defined tumor types, expression of at least one of the SSX family members was most frequently observed in head and neck cancer (75%), followed by ovarian cancer (50%), malignant melanoma (43%), lymphoma (36%), colorectal cancer (27%) and breast cancer (23%), while leukemias and the few cases of leiomyosarcomas, seminomas and thyroid cancers were found not to express any SSX gene.
Early Screening of Oxacillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis from Blood Culture (2002)

The timely detection of blood-borne pathogens is one of the most important functions of the microbiology laboratory. Recently, methicillin-resistant staphylococci have become the most important pathogens seen by the laboratory. The purpose of this study was to evaluate Staphy agar, a novel screening medium, for the detection methicillin-resistant Staphylococcus aureus, S. epidermidis, or other coagulase-negative staphylococci (CNS) from positive blood cultures showing Gram-positive cocci in clusters. Eighty-six blood cultures that yielded Gram-positive cocci in clusters were included in this study. The organisms were finally identified by the Vitek system, and oxacillin resistance was confirmed by polymerase chain reaction (PCR)-based mecA gene detection. The identification and oxacillin resistance of all S. aureus strains showed complete agreement with the Vitek and PCR results. The presumptive detection of S. epidermidis and other CNS were consistent with the Vitek system in 94.7%, and the screening of oxacillin resistance was consistent with the result of PCR in 92.1% of 38 strains. The Staphy agar method is reliable and rapid for differentiating Gram-positive cocci in clusters in blood and for determining their methicillin resistance.
Correlation between current leakage and structural properties of threading dislocations in GaN bulk single crystals grown using a Na-flux method (2019)

Abstract This work investigated the electrical and microstructural properties of threading dislocations (TDs) in Na-flux-grown GaN bulk single crystals composed entirely of a c -plane growth sector ( c GS). Several microscale Schottky-like contacts fabricated on TD-related etch pits and flat (0001) surfaces were analyzed via a combination of conductive atomic force microscopy, multi-photon excitation photoluminescence and transmission electron microscopy. Significant current leakage was observed in microscale facet growth sectors ( μ -FGSs), having high local oxygen impurity concentrations, that had formed in the c GS. Higher leakage currents were found to be associated with bundled a type and a + c type TDs, whereas lower leakage currents were produced by single a type TDs. The leakage current evidently increased as the size of etch pits formed on the μ -FGSs increased. These observations establish a close correlation between current leakage and TD-induced strain fields that affect the distribution of point defects such as oxygen impurities around TDs.
A Knockout Switch for Variable-Length Packets (1987)

The Knockout Switch is a new packet switch architecture recently proposed for high-speed local and metropolitan area networks, multiprocessor interconnects, and local or toll switches for integrated traffic loads. We describe an approach to extend the original Knockout Switch to work with variable-length packets. This new architecture employs an input broadcast bus arrangement to achieve complete interconnection of the inputs and outputs. Consequently, there is no congestion in the switch fabric other than the unavoidable conflict of multiple simultaneous packets destined for the same output. It is with this output contention that the Knockout principle is fully utilized to efficiently concentrate and store contending packets while maintaining the first-in first-out discipline of the packet sequence; and yet the fabric speed required is no more than the input/output line speeds, Under these design goals, no switch can yield better delay/ throughout performance. These are the most important attributes that have been preserved in the current proposal from the original Knockout Switch. For an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N \times N</tex> switch configuration, the variable-length packet Knockout Switch consists of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> input broadcast buses, and an <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N:L</tex> concentrator ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L \ll N</tex> ) and a shared buffer for each output. The design of each subsystem is discussed with emphasis on possible VLSI realization. Using today's technology, we should be able to implement the proposed switch with both input/output lines and internal hardware operating at 50 Mbits/s. The dimension of the switch ( <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N \times N</tex> ) can grow modularly from say 32 × 32 to 1024 × 1024, rendering a total throughput in the range of tens of gigabits per second. Future upgrading of the line interfaces to much higher speed without modification to the internal switch hardware is also possible with a modest restriction on the minimum length of new packets.
A Fast Fourier Transform Analysis of Time Series Data of Heart Rate Variability During Alfa-Rhythm Stimulation in Brain Entrainment (2013)

The physical technique of the brain entrainment (BWE) is used and simultaneously time series data of R-R intervals are recorded during rest and alfa brain stimulation. The performed Fast Fourier Analysis evidences that, respect to the rest case, alfa brain stimulation induces a constant improvement in the total power spectral density and in particular in the HF band spectrum. The result is of interest for further consideration by clinicians and researchers of BWE as basic therapeutic tool.???
Synchronization algorithms for shared-memory multiprocessors (1990)

A performance evaluation of the Symmetry multiprocessor system revealed that the synchronization mechanism did not perform well for highly contested locks, like those found in certain parallel applications. Several software synchronization mechanisms were developed and evaluated, using a hardware monitor, on the Symmetry multiprocessor system; the mechanisms were to reduce contention for the lock. The mechanisms remain valuable even when changes are made to the hardware synchronization mechanism to improve support for highly contested locks. The Symmetry architecture is described, and a number of lock algorithms and their use of hardware resources are examined. The performance of each lock is observed from the perspective of both the program itself and the total system performance. >
Differential Expression and Antibacterial Activity of Epididymis Protein 2 Isoforms in the Male Reproductive Tract of Human and Rhesus Monkey (Macaca mulatta)1 (2004)

The epididymis protein 2 (EP2) gene, the fusion of two ancestral beta-defensin genes, is highly expressed in the epididymis and subject to species-specific regulation at the levels of promoter selection, transcription, and mRNA splicing. EP2 mRNA expression is also androgen dependent, and at least two of the secreted proteins bind spermatozoa. Alternative splicing produces more than 17 different EP2 mRNA variants. In this article, the expression of EP2 variants was profiled in different tissues from the human and rhesus monkey (Macaca mulatta) male reproductive tract using reverse transcriptase-polymerase chain reaction. Different EP2 mRNA variants were identified not only in human and rhesus testis and epididymis but also in the novel sites, seminal vesicle and prostate. Immunolocalization of EP2 protein in epithelial cells from rhesus and human seminal vesicle demonstrated that EP2 transcripts are translated in these tissues. In addition, two novel splicing variants, named EP2R and EP2S, were discovered. EP2C was the only splice variant expressed in all tissues tested from rhesus monkey. However, expression was not detected in human testis or seminal vesicle. For the first time, bactericidal function was demonstrated for EP2C, EP2K, and EP2L. Taken together, the results indicate that EP2 expression is more widespread in the male reproductive tract than realized previously. Whereas the activity of every EP2 variant tested thus far is antibacterial, further investigation may reveal additional physiological roles for EP2 peptides in the primate male reproductive tract.
The role ofN‐methyl‐D‐asparate receptors in neurogenesis (2006)

The dentate gyrus continues to incorporate granule neurons during adulthood. Among the factors that we know modulate adult neurogenesis in the dentate gyrus, one of the first studied was the influence of excitatory amino-acids. These neurotransmitters, acting through NMDA receptors, are able to modulate both the proliferation of progenitor cells as well as the rate of neurogenesis in the adult dentate gyrus. However, the mechanisms by which these processes are influenced are not clearly known. Although there is no anatomical evidence of NMDA receptor expression in adult hippocampal progenitor cells or differentiating granule neurons, electrophysiological data and in vitro studies suggest that NMDA receptors may be expressed by certain precursor cells and immature granule neurons. This review summarizes findings on the influence of pharmacological manipulation of NMDA receptors on adult neurogenesis. We also analyze previous studies that have suggested the expression of NMDA receptors in progenitors and immature granule cells and discuss the putative role of these receptors in the regulation of developmental processes such as proliferation, migration, or neurite outgrowth.
High-dose combination alkylating agents with bone marrow support as initial treatment for metastatic breast cancer. (1988)

To evaluate the effect of high-dose chemotherapy in the treatment of metastatic breast cancer, we performed a phase II trial of a single treatment with high-dose cyclophosphamide (5,625 mg/m2), cisplatin (165 mg/m2), and carmustine (600 mg/m2), or melphalan (40 mg/m2) and bone marrow support as the initial chemotherapy for metastatic breast cancer. Twenty-two premenopausal patients with estrogen receptor negative, measurable metastatic disease were treated. Twelve of 22 patients (54%) obtained a complete response at a median 18 days. The overall response rate is 73% (complete and partial response). Median duration of response in the patients achieving complete response was 9.0 months with a median duration of survival for complete responders that is currently undefined. Relapse occurred predominantly at sites of pretreatment bulk disease or within areas of previous radiation therapy. Toxicity was frequent and five patients died of therapy-related complications. The results indicate that a single treatment with intensive combination alkylating agents with bone marrow support can produce more rapid and frequent complete responses than conventional chemotherapy when used as initial chemotherapy for metastatic breast cancer, although median disease-free and overall survival is not improved. Three patients (14%) remain in unmaintained remission beyond 16 months.
Speckle Interferometry: Diffraction-Limited Measurements of Nine Stars with the 200-INCH Telescope (1972)

A new method has enabled us to repeat most of the classical Michelson-Pease measurements of stellar diameters. Stellar images are photographed "coherently" with a special camera. They contain a fine structure from which diffraction-limited information is extracted by optical processing. Nine of the stars observed were resolved, showing angular dimensions as small as 0.016. Limb darkening is evidenced in a Ori, and a faint companion is found for Cep.
Severely Injured Trauma Patients with High Circulating IL-15 Levels Display Worse Outcomes and Distinct Inflammatory Profiles, Suggesting a Role for Natural Killer Cell Activation (2019)

Lamparello, Ashley J. MD; Zamora, Ruben PhD; Namas, Rami A. MD; Vodovotz, Yoram PhD; Billiar, Timothy R. MD, FACS Author Information
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse (2000)

We have identified conditions for forming cultured human umbilical vein endothelial cells (HUVEC) into tubes within a three-dimensional gel that on implantation into immunoincompetent mice undergo remodeling into complex microvessels lined by human endothelium. HUVEC suspended in mixed collagen/fibronectin gels organize into cords with early lumena by 24 h and then apoptose. Twenty-hour constructs, s.c. implanted in immunodeficient mice, display HUVEC-lined thin-walled microvessels within the gel 31 days after implantation. Retroviral-mediated overexpression of a caspase-resistant Bcl-2 protein delays HUVEC apoptosis in vitro for over 7 days. Bcl-2-transduced HUVEC produce an increased density of HUVEC-lined perfused microvessels in vivo compared with untransduced or control-transduced HUVEC. Remarkably, Bcl-2- but not control-transduced HUVEC recruit an ingrowth of perivascular smooth-muscle alpha-actin-expressing mouse cells at 31 days, which organize by 60 days into HUVEC-lined multilayered structures resembling true microvessels. This system provides an in vivo model for dissecting mechanisms of microvascular remodeling by using genetically modified endothelium. Incorporation of such human endothelial-lined microvessels into engineered synthetic skin may improve graft viability, especially in recipients with impaired angiogenesis.
Polymers on Nanoperiodic, Heterogeneous Surfaces (1999)

Herein we establish a relationship between controlled nanoscale surface interactions and subsequent macromolecular ordering. Striped surfaces of oxide and metal are generated over large areas, where the stripe width is comparable to the size of a polymer molecule. Homopolymers are found to anisotropically dewet such surfaces, while incompatible polymer mixtures phase separate at the substrate/polymer interface on a molecular level. An orientation of lamellar block copolymer microdomains normal to the surface is found, when substrate and polymer length scales are commensurate.
Design and control of an unmanned aerial vehicle (UAV) based on the Coand&#x0103; effect (2013)

In this paper, we present an unmanned aerial vehicle (UAV) called VTOL. we designed the overall shape of the UAV. we determined the optimal surface shape of the vehicle and the ratio of width to height of the saucer. Finally, we built the UAV and controlled its flight using anti-torque and flap links.
Synthesis of Branched Gold Nanocrystals by a Seeding Growth Approach (2005)

Synthesis of branched gold nanocrystals by a seeding growth approach is described. In this process, HAuCl4 aqueous solution was supplied stepwise to grow the gold seeds (approximately 2.5 nm) into larger nanoparticles with a highly faceted particle structure (approximately 15-20 nm in diameter). Sodium dodecyl sulfate (SDS) served as a capping agent to facilitate the formation of highly faceted nanoparticles, and ascorbic acid was used as a weak reducing agent. The highly faceted nanoparticles then transformed into branched nanocrystals (approximately 40 nm in length) by further addition of the SDS-HAuCl4 solution and ascorbic acid for particle growth. The branched nanocrystals show bipod, tripod, tetrapod, and pentapod structures and are composed of mainly (111) lattice planes. These multipods appear to grow along the twin boundaries of the initially formed highly faceted gold nanoparticles, as the twin boundaries on the pods originate from the centers of the branched nanocrystals. The concentration of ascorbate ions in the solution was found to have a profound influence on branch formation. These branched nanocrystals are stable to storage at low temperature (that is, 4 degrees C), but they may slowly evolve into a multitwinned faceted crystal structure (that is, pentagonal-shaped decahedral structure) when stored at 30 degrees C.
Reflections on Friendster, Trust and Intimacy (2003)

By asking users to articulate and negotiate intimate information about themselves and their relationships, Friendster.com positions itself as a site for identity-driven intimate computing. Yet, trust issues are uncovered as users repurpose the site for playful intimacy and creativity. To flesh out the tension between purpose and desire, i reflect on Friendster’s architecture, population and usage.
New relaxation of merging spheromaks to a field reversed configuration (1999)

A novel high β relaxation to a field reversed configuration (FRC) has been investigated by axially colliding two spheromaks with opposing toroidal magnetic fields. The β value of the merging toroids increases from 0.1 to 0.7-1.0 within 15 μs, indicating an equilibrium transition from the low β spheromak to the high β FRC. An important finding is that the merging spheromaks relax either to a high β FRC or to another low β spheromak, depending on whether the initial normalized magnetic helicity given to these spheromaks is smaller or larger than a threshold value. This fact suggests that the FRCs are equipped with some global stability as robust as the Taylor magnetic energy minimum state.