gebhart/patrepeval huggingface dataset:
Predictive deconvolution and the zero-phase source (1984)

Abstract The phase correction is given by the minimum-phase spectrum of the correlated Vibroseis wavelet. Because no minimum-phase spectrum truly exists for this band-limited wavelet, white noise is added to its amplitude spectrum in order to design the phase-correction filter. Different levels of white noise, however, produce markedly different results when field data sections are filtered. A simple argument suggests that the amount of white noise used should match that added in designing the (minimum-phase) spiking deconvolution operator. This choice, however, also produces inconsistent results; field data again show that the phase treatment is sensitive to the amount of added white noise. Synthetic data tests show that the standard phase correction procedure breaks down when earth attenuation is severe. Deterministically reducing the earth-filter effects before deconvolution improved the resulting phase treatment for the synthetic data. After application of the inverse attenuation filter to the field data, however, phase differences again remain for different levels of added white noise. These inconsistencies are attributable to the phase action of spiking deconvolution. This action is dependent upon the shape of the signal spectrum as well as the spectral shape and level of contaminating noise. Thus, in practice the proper treatment of phase in data-dependent processing requires extensive knowledge of the spectral characteristics of both signal and noise. With such knowledge, one could apply deterministic techniques that either eliminate the need for statistical deconvolution or condition the data so as to satisfy better the statistical model assumed in data-dependent processing.--Modified journal abstract.
Prevalence and Pathologic Features of Sickle Cell Nephropathy and Response to Inhibition of Angiotensin-Converting Enzyme (1992)

Approximately 25 percent of patients with sickle cell disease have proteinuria. Treatment with enalapril reduces the degree of proteinuria in these patients, suggesting that glomerular capillary hypertension may be a pathogenic factor in sickle cell nephropathy.
Systemic use of tumor necrosis factor alpha as an anticancer agent (2011)

Tumor necrosis factor-α (TNF-α) has been discussed as a potential anticancer agent for many years, however initial enthusiasm about its clinical use as a systemic agent was curbed due to significant toxicities and lack of efficacy. Combination of TNF-α with chemotherapy in the setting of hyperthermic isolated limb perfusion (ILP), has provided new insights into a potential therapeutic role of this agent. The therapeutic benefit from TNF-α in ILP is thought to be not only due to its direct anti-proliferative effect, but also due to its ability to increase penetration of the chemotherapeutic agents into the tumor tissue. New concepts for the use of TNF-α as a facilitator rather than as a direct actor are currently being explored with the goal to exploit the ability of this agent to increase drug delivery and to simultaneously reduce systemic toxicity. This review article provides a comprehensive overview on the published previous experience with systemic TNF-α. Data from 18 phase I and 10 phase II single agent as well as 18 combination therapy studies illustrate previously used treatment and dose schedules, response data as well as the most prominently observed adverse effects. Also discussed, based on recent preclinical data, is a potential future role of systemic TNF-α in combination with liposomal chemotherapy to facilitate increased drug uptake into tumors.
Mobile assistant for elderly (MAE) (2012)

Our world population is ageing and it is projected that in Singapore alone, 20% of Singapore Population will reach above the age of 65 in year 2030 with current population growth rate. The increase in the proportion of ageing persons (65 years or older) is accompanied by the decline in the proportion of young person (age of 15). Therefore, it is a challenging for the nations and researchers for to design and promote technologies to help the ageing population to remain independent and preserve the quality of life. This paper presents our system, MAE, and how the system is used to provide independence and mobility to elderly while supporting the individual caregivers or care-organizations to enhance their care-experiences and services.
Securities Trading in the Absence of Dealers: Trades and Quotes on the Tokyo Stock Exchange (1995)

Yasushi HamaoColumbia UniversityJoel HasbrouckNew York UniversityThis article investigates the behavior of intra-day trades and quotes for individual stocks onthe Tokyo Stock Exchange (TSE). We examine thetransaction and quote record for three firms forthe first 3 months of 1990. Our findings suggestthat the immediacy available (at least for smalltrades) in the market is high, despite the re-liance on public limit orders to supply liquidity.When orders that would otherwise walk throughthe limit order book are converted into limit or-ders, execution is delayed; but some orders exe-cute (at least in part) at more favorable prices.
Maturation of Embryonic Stem Cells Into Endothelial Cells in an In Vitro Model of Vasculogenesis (1999)

A primitive vascular plexus is formed through coordinated regulation of differentiation, proliferation, migration, and cell-cell adhesion of endothelial cell (EC) progenitors. In this study, a culture system was devised to investigate the behavior of purified EC progenitors in vitro. Because Flk-1(+) cells derived from ES cells did not initially express other EC markers, they were sorted and used as EC progenitors. Their in vitro differentiation into ECs, via vascular endothelial-cadherin (VE-cadherin)+ platelet-endothelial cell adhesion molecule-1 (PECAM-1)+ CD34(-) to VE-cadherin+ PECAM-1(+) CD34(+) stage, occurred without exogenous factors, whereas their proliferation, particularly at low cell density, required OP9 feeder cells. On OP9 feeder layer, EC progenitors gave rise to sheet-like clusters of Flk-1(+) cells, with VE-cadherin concentrated at the cell-cell junction. The growth was suppressed by Flt-1-IgG1 chimeric protein and dependent on vascular endothelial growth factor (VEGF) but not placenta growth factor (PIGF). Further addition of VEGF resulted in cell dispersion, indicating the role of VEGF in the migration of ECs as well as their proliferation. Cell-cell adhesion of ECs in this culture system was mediated by VE-cadherin. Thus, the culture system described here is useful in dissecting the cellular events of EC progenitors that occur during vasculogenesis and in investigating the molecular mechanisms underlying these processes.
A perspective on HPK1 as a novel immuno-oncology drug target (2020)

In this perspective review, the role Hematopoietic Progenitor Kinase 1 (HPK1) in tumor immunity will be reviewed, with special emphasis on how T cells are negatively-regulated at different junctures of cancer-immunity cycle by this regulatory kinase. The review will highlight the strengths and weaknesses of HPK1 as a candidate target for novel immuno-oncology (IO) drug development that is centered on the use of small molecule kinase inhibitor to modulate the immune response against cancer. Such a therapeutic approach, if proven successful, could supplement the cancer cell-centric standard of care therapies in order to fully meet the therapeutic needs of cancer patients.
Selection of Bacillus subtilis 168 Mutants with Deletions of the PBSX Prophage (1980)

Heat-resistant derivatives of a Bacillus subtilis 168 strain carrying an xhi mutation, which causes heat-sensitive induction of the PBSX prophage, have been isolated and screened for the acquisition of auxotrophy. Two classes of auxotrophs were isolated, namely Pro- and Pro-Met-; they lacked the ability to produce PBSX, as shown by their resistance to mitomycin C-induced lysis. The proline and methionine requirements and the resistance to mitomycin C were shown to segregate together in phage PBS1-mediated transduction crosses and to be linked to thiB, which is known to be co-transducible with the PBSX prophage. It was therefore proposed that these strains had deletions which removed all or part of the PBSX prophage together with adjacent bacterial DNA encoding the pro(AB) and metC genes. The met mutation was shown to be metC in PBS1 transduction crosses; this gene is known to be co-transducible with the PBSX prophage. The proline requirement was probably due to the deletion of a pro gene which was demonstrated to lie between the PBSX prophage and metC and which was 90% co-transducible with metC. These deletions have been transduced into a strain which was cured of phage SP beta, another bacteriophage carried by B. subtilis 168. No phage particles could be seen in mitomycin C-induced cultures of such strains. The PBSX-deletion strains grew with the same generation time as the PBSX+ parent in L-broth (27 min at 35 degrees C) but they were slower in minimal medium (e.g. 72 min as against 51 min in the PBSX+ strain). Besides being resistant to mitomycin C-induced lysis, the deletion strains were also resistant to lysis induced by thymine starvation of thymine auxotrophs and the loss of viability of these strains after thymine starvation was 100-fold less than in the PBSX+ parent. The deletion strains had not, however, lost the bacterial autolytic enzymes, since they were still susceptible to lysis when placed under semi-anaerobic conditions.
Prevalence of Cam Morphology in Females with Femoroacetabular Impingement (2015)

Cam and pincer are two common morphologies responsible for femoroacetabular impingement (FAI). Previous literature has reported that cam deformity is predominantly a male morphology, while being significantly less common in females. Cam morphology is commonly assessed with the alpha angle, measured on radiographs. The purpose of this study is to determine the prevalence of cam morphology utilizing the alpha angle in female subjects diagnosed with symptomatic FAI. All females presenting to the senior author's clinic diagnosed with symptomatic FAI between December 2006 and January 2013 were retrospectively reviewed. Alpha (α) angles were measured on anteroposterior and lateral (Dunn 90°, cross-table lateral, and/or frog-leg lateral) plain radiographs by two blinded physicians, and the largest measured angle was used. Using Gosvig et al.'s classification, alpha angle was characterized as (pathologic > 57°), borderline (51-56°), subtle (46-50°), very subtle (43-45°), or normal (≤42°). Three hundred and ninety-one patients (438 hips) were analyzed (age 36.2 ± 12.3 years). Among the hips included, 35.6% were normal, 14.6% pathologic, 15.1% borderline, 14.6% subtle, and 20.1% very subtle. There was no correlation between alpha angle and patient age (R = 0.17) or body mass index (R = 0.05). The intraclass correlation coefficient for α-angle measurements was 0.84. Sixty-four percent of females in this cohort had an alpha angle >42°. Subtle cam deformity plays a significant role in the pathoanatomy of female patients with symptomatic FAI. As the majority of revision hip arthroscopies are performed due to incomplete cam correction, hip arthroscopists need to be cognizant of and potentially surgically address these subtle lesions.
Effects of copper micro-particles on the detonation characteristics of RDX powder (2009)

The effects of copper micro-particles on the detonation characteristics of RDX powder were investigated in a horizontal shock tube with internal dimensions of 100 mm diameter and 4 m length using an instantaneous spectrum detection apparatus. The emergence time and emission spectral intensity of the main products such as NO2, H, C2, O, CO, CH2O, CO2 and H2O were observed by a TDS5054 oscilloscope. With or without the addition of copper micro-particles into RDX, NO2 appears first in every experiment, which is in agreement with theoretical results. However, the addition of copper micro-particles to RDX can shorten the emergence time by 7–18%; it can also increase the peak blast pressure by about 133%. In addition, O2, H2O and CH2O in various quantities were introduced into this experiment, respectively, which indicate that O2 can obviously affect the results that may shorten the emergence time of NO2 by 31% and increase the peak blast pressure by 167%.
Characterization of phosphoglycan-containing secretory products ofLeishmania (1994)

This article presents an overview on phosphoglycan-containing components secreted by the insect and mammalian stages of several species of Leishmania, the causative agents of leishmaniasis in the Old and New World. Firstly, promastigotes of all three species considered, L. mexicana, L. donovani and L. major, shed lipophosphoglycan (LPG) into the culture medium possibly by release of micelles from the cell surface. Like the cell-associated LPG, culture supernatant LPG is amphiphilic and composed of a lysoalkylphosphatidylinositol-phosphosaccharide core connected to species-specific phosphosaccharide repeats and oligosaccharide caps. Secondly, all three species release hydrophilic phosphoglycan. Thirdly, all three species appear to secrete proteins covalently modified by phosphosaccharide repeats and oligosaccharide caps. In the case of promastigotes of L. mexicana, these components are organized as two filamentous polymers released from the flagellar pocket: the secreted acid phosphatase (sAP) composed of a 100 kDa phosphoglycoprotein and a protein-containing high-molecular-weight-phosphoglycan (proteo-HMWPG) and fibrous networks likewise composed of phosphoglycan possibly linked to protein. Structural analyses and gene cloning suggest that the parasites can covalently modify protein regions rich in serine and threonine residues by the attachment of phosphosaccharide repeats capped by oligosaccharides. We propose that the networks formed in vitro correspond to fibrous material previously demonstrated in the digestive tract of infected sandflies. In the case of L. donovani, the sAP is also modified by phosphoglycans but contains neither proteo-HMWPG nor does it aggregate to filaments. Finally, L. mexicana amastigotes release proteo-HMWPG via the flagellar pocket into the parasitophorous vacuole of infected macrophages.(ABSTRACT TRUNCATED AT 250 WORDS)
Nucleolar and nuclear envelope proteins of the yeast Saccharomyces cerevisiae. (1988)

We have developed a fast and reliable purification protocol to obtain yeast nuclei in intact and pure form and in a reasonable yield. The purified nuclei appear homogeneous at the light and electron microscopic level, are highly enriched in the nuclear marker histone H2B and devoid of mitochondrial, vacuolar and cytosolic marker proteins. On sodium dodecyl sulfate (SDS)-polyacrylamide gels, the nuclear fraction contains unique proteins which distinguishes them from the major yeast subcellular fractions. Yeast nuclei were separated by detergent/salt extraction into soluble, insoluble and membrane fractions. Antibodies raised against subnuclear fractions lead to the identification of an integral nuclear membrane protein and a high-abundance 38-kDa protein which is located in the yeast nucleolus.
Interleukin-17 enhances tumor necrosis factor ?-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: A possible role as a ?fine-tuning cytokine? in inflammation processes (2001)

Our findings suggest that the primary role of IL-17 is to synergize with TNFalpha and to fine-tune the inflammation process. Therefore, IL-17 may be a potential target for therapeutic intervention.
Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis (2000)

The neu (c-erbB-2, Her-2) protooncogene is amplified and overexpressed in 20-30% of human breast cancers. Although transgenic mouse models have illustrated the role of Neu in the induction of mammary tumors, Neu expression in these models is driven by a strong viral promoter of questionable relevance to the human disease. To ascertain whether expression of activated Neu under the control of the endogenous promoter in the mammary gland could induce mammary tumors we have generated mice that conditionally express activated Neu under the transcriptional control of the intact endogenous Neu promoter. Expression of oncogenic neu in the mammary gland resulted in accelerated lobulo-alveolar development and formation of focal mammary tumors after a long latency period. However, expression of activated Neu under the normal transcriptional control of the endogenous promoter was not sufficient for the initiation of mammary carcinogenesis. Strikingly, all mammary tumors bear amplified copies (2-22 copies) of the activated neu allele relative to the wild-type allele and express highly elevated levels of neu transcript and protein. Thus, like human erbB-2-positive breast tumors, mammary tumorigenesis in this mouse model requires the amplification and commensurate elevated expression of the neu gene.
Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane (2006)

Stromal interacting molecule 1 (STIM1), reported to be an endoplasmic reticulum (ER) Ca(2+) sensor controlling store-operated Ca(2+) entry, redistributes from a diffuse ER localization into puncta at the cell periphery after store depletion. STIM1 redistribution is proposed to be necessary for Ca(2+) release-activated Ca(2+) (CRAC) channel activation, but it is unclear whether redistribution is rapid enough to play a causal role. Furthermore, the location of STIM1 puncta is uncertain, with recent reports supporting retention in the ER as well as insertion into the plasma membrane (PM). Using total internal reflection fluorescence (TIRF) microscopy and patch-clamp recording from single Jurkat cells, we show that STIM1 puncta form several seconds before CRAC channels open, supporting a causal role in channel activation. Fluorescence quenching and electron microscopy analysis reveal that puncta correspond to STIM1 accumulation in discrete subregions of junctional ER located 10-25 nm from the PM, without detectable insertion of STIM1 into the PM. Roughly one third of these ER-PM contacts form in response to store depletion. These studies identify an ER structure underlying store-operated Ca(2+) entry, whose extreme proximity to the PM may enable STIM1 to interact with CRAC channels or associated proteins.
A proxy-based personal web archiving service (2001)

The Web contains so much information that it is almost beyond measure. How do users manage the useful information that they have seen while screening out the rest that doesn't interest them? Bookmarks help, but bookmarking a page doesn't guarantee that it will be available forever. Search engines are becoming more powerful, but they can't be customized based on the access history of individual users. This paper suggests that a better alternative to managing web information is through a middleware approach based on iPROXY, a programmable proxy server. iPROXY offers a suite of archiving, retrieval, and searching services. It can extend a URL to include commands that archive and retrieve pages. Its modular architecture allows users to plug in new features without having to change existing browsers or servers. Once installed on a network, iPROXY can be accessed by users using different browsers and devices. Internet service providers who offer customers iPROXY will be free to develop new services without having to wait for the dominant browsers to be updated.
A longitudinal clinical study of Procera ceramic-veneered titanium copings. (1999)

Of the various clinical factors evaluated, only surface and color-related to the low-fusing ceramic used for veneering-showed any obvious change during the follow-up period. Otherwise the veneered titanium copings had, in general, performed well.
Analysis and Potential of the Bipolar- and Hybrid-Mode Thin-Film SOI MOSFETs for High-Temperature Applications (2001)

Besides the fully-depleted SOI MOSFET and its several \nadvantages which have widely been reported in the \nliterature in the last few years [1], thin-film SOI technology \nalso allows for the processing of lateral bipolar transistors. \nThese devices have already shown very good performances \nin current and voltage references [2,3] and could be \nintegrated in other high-temperature precision analog \ncircuits. \nIn this work, we analyze, from room temperature up to \n300°C, the analog performances of the SOI lateral bipolar \ntransistor, by distinguishing two modes of operation: the \npure bipolar mode and the hybrid mode. The results are \ncompared with the standard MOSFET performances.
Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines (1978)

A series of mono-, bi-, and tricyclic pyrimidines and as-triazines was prepared and their antiinflammatory activity measured against carrageenan-induced edema in the rat. The more active analogues (ED50), including 4-pyri-dylpyrimidines 4a (38), 4b (47), and 4g (49) and 2-hydroxypyrimidine 8r (43), were then tested against adjuvant-induced edema in the rat. None was active in the adjuvant arthritis model.
A Novel Intraarterial Chemotherapy Using Paclitaxel in Albumin Nanoparticles to Treat Advanced Squamous Cell Carcinoma of the Tongue: Preliminary Findings (2003)

Intraarterial infusion of paclitaxel in albumin nanoparticles proved reproducible and effective and deserves further investigation as induction chemotherapy before definitive treatment of advanced tumors of the tongue, with a view to organ preservation.
The legal and ethical aspects of telemedicine. 1: Confidentiality and the patient's rights of access (1997)

This paper reviews the principle of confidentiality and the rights of access by patients to their medical records. Confidentiality has been germane to the ethics of medical practice since the time of Hippocrates but the nature of the legal obligation of confidence does not have such a clear pedigree. The introduction of cross-border telemedical consultations presents a very real danger to maintaining the confidentiality of medical data. While both the common law and statute law can be used to prevent the unauthorized interception and disclosure of medical data and protect the patient's rights of access and ownership in the UK, it is the harmonization regime of the European Union that will bring comprehensive regulation and legal clarity to the protection of patients' rights within an increasingly international medical 'super-specialty'.
Self-pop-up cylindrical structure by global heating (2013)

In this study, we demonstrate a new approach to autonomous folding for the body of a 3D robot from a 2D sheet using heat. We approach this challenge by folding a 0.27 mm sheet-like material into a structure. We utilize the thermal deformation of a contractive sheet sandwiched by rigid structural layers. During this “baking” process, the heat applied on the entire sheet induces contraction of the contracting layer and, thus, forms an instructed bend in the sheet. To attain the targeted folding angles, the V-fold Spans method is used. The targeted angle θ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">out</sub> can be kinematically encoded into crease geometry. The realization of this angle in the folded structure can be approximately controlled by a contraction angle θ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</sub> . The process is non-reversible, is reliable, and it is relatively fast. Our method can be applied simultaneously to all the folds in multi-creased origami structures. We demonstrate the use of this method to create a light-weight mobile robot.