gebhart/patrepeval huggingface dataset:
Endocytosis, Recycling, and Degradation of the Insulin Receptor (1989)

The endocytosis, recycling, and degradation of the insulin receptor were studied in IM-9 cells and U-937 cells by employing two monoclonal antibodies directed at the alpha subunit of the human insulin receptor, antibodies MA-5 and MA-10. Antibody MA-5 is an insulin agonist and MA-10 is an insulin antagonist (Forsayeth, J., Caro, J.F., Sinha, M.K., Maddux, B.A., and Goldfine, I.D. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 3448-3451). Both monoclonal antibodies, like insulin, induced the endocytosis of the insulin receptor within 15 min. Upon removal of extracellular ligand the internalized receptor recycled to the cell surface. At this time there was no degradation of the receptor as measured by a sensitive insulin receptor radioimmunoassay. After 20 h of incubation, insulin and MA-5, but not MA-10, induced significant receptor degradation as measured by both insulin receptor radioimmunoassay and metabolic labeling studies. These studies demonstrated, therefore, that: 1) internalization and recycling of the receptor can be induced by antireceptor monoclonal antibodies that are either insulin agonists or insulin antagonists; 2) enhanced receptor degradation can be induced by monoclonal antibodies that are insulin agonists; and 3) the process of receptor internalization does not necessarily lead to enhanced receptor degradation. Since prior studies have indicated that neither MA-5 nor MA-10 enhance insulin receptor kinase activity, the present studies also suggest that insulin receptor endocytosis and degradation induced by ligands different than insulin can occur without activation of this process.
Attenuation of free-surface multiples by up/down deconvolution for marine towed-streamer data (2011)

ABSTRACT Free-surface-related multiples in marine seismic data are commonly attenuated using adaptive subtraction of the predicted multiple energy. An alternative method, based on deconvolution of the upgoing wavefield by the downgoing wavefield, was previously applied to ocean-bottom data. We apply the deconvolution method to towed-streamer data acquired in an over/under configuration. We also use direct arrival deconvolution that results in source wavelet designature only, as a benchmark to verify the full multiple deconvolution result. Detailed synthetic data analysis, including sensitivity tests, explains each data processing step and its effects on the final result. We then apply this verified preprocessing sequence to field data from the Kristin area of the North Sea, with a focus on the direct arrival prediction using the near-field hydrophone method. Prestack evaluation of the results shows that the method applied to the field data provides designature, source-side deghosting, and attenuation of multiples. We show comparable stacked results from our method and from 2D iterative surface-related multiple elimination. The workflow has the benefit that it does not require an adaptive subtraction step or iterative application. However, an accurate direct arrival prediction is essential for the successful application of the method. This prediction is obtained using near-field hydrophone measurements that can be recorded with some commercial acquisition systems.
Increased Norepinephrine Levels and Decreased Dopamine-β-Hydroxylase Activity in Primary Autism (1977)

The sympathetic nervous system was evaluated in 11 primary autistic patients and their families. The plasma levels of norepinephrine (NE), the neurotransmitter of the sympathetic nervous system, was higher in the patients than in age-controlled normal volunteers both while supine and after standing. The plasma activity of dopamine-beta-hydroxylase, the enzyme that converts dopamine to NE, was significantly lower in the autistic patients and their healthy relatives than in control groups. Dopamine-beta-hydroxylase does not appear to provide an index of sympathetic activity in this group of patients who, on the basis of the elevated plasma levels of NE, may demonstrate a chronic state of hyperactivity of the sympathetic nervous system. Low enzyme activity found in both the autistic patients and their immediate families may be associated with this disorder.
Room-Temperature Phosphorescent Palladium−Porphine Probe for DNA Determination (1997)

Room-temperature phosphorescence (RTP) enhancement of a palladium-porphine complex by DNA was studied. Studies involving calf thymus DNA and calf liver RNA revealed that the Pd-porphine complex bound to double-stranded DNA displayed intense RTP, while a very weak RTP emission was observed in the presence of equal molar concentrations of RNA. This fact founded a basis for selective determination of DNA in the presence of RNA. Maximum phosphorescence was observed at pH 7, with maximum excitation and emission wavelengths at 435 and 680 nm, respectively. Under optimal experimental conditions, the calibration graphs were linear up to 6 × 10(-)(5) μM DNA. The detection limit was 5 × 10(-)(8) μM and the relative standard deviation (10 replicates) ±2.6% in the linear range. DNA extracted from human colon tissues could be successfully determined.
Targeting One or More Potential Journals (2008)

Abstract Perhaps the single most important decision to be made by an author, in terms of getting a research article successfully published, is selecting the appropriate peer-reviewed professional journal to send it to. Submission to an inappropriate journal will likely doom it to eventual rejection. This chapter discusses the pros and cons of submitting one's research articles to a disciplinary social work journal, to a non-social work disciplinary (e.g., psychology, economics, sociology) journal, or to an interdisciplinary (e.g., family therapy, child welfare, gerontology) journal. Also discussed are factors such as selecting highly reputable (and correspondingly difficult to get into) versus newer or less well-known journals (often easier to get into), a journal's publication lag time, whether the journal is picked up by major abstracting services, and the increasingly important impact factor of a given journal. The pros and cons of publishing in journals availably solely via the internet are also presented.
Hemolytic activity of Borrelia burgdorferi (1992)

Zones of beta-hemolysis occurred around colonies of Borrelia burgdorferi grown on Barbour-Stoenner-Kelly medium containing agarose and horse blood. Blood plates were inoculated with either the infective strain Sh-2-82 or noninfective strain B-31 in an overlay and incubated in a candle jar. Both strains of B. burgdorferi displayed beta-hemolysis after 1 to 2 weeks of incubation. The hemolytic activity diffused out from the borrelial colonies, eventually resulting in lysis of the entire blood plate. Hemolysis was most pronounced with horse blood and was less intense with bovine, sheep, and rabbit blood. Hemolysis was enhanced by hot-cold incubation, which is typical of phospholipase-like activities in other bacteria. Further characterization of the borrelial hemolysin by using a spectrophotometric assay revealed its presence in the supernatant fluids of stationary-phase cultures. Detection of the borrelial hemolytic activity was dependent on activation of the hemolysin by the reducing agent cysteine. This study provides the first evidence of hemolytic activity associated with B. burgdorferi.
An analysis of pilot symbol assisted modulation for Rayleigh fading channels (mobile radio) (1991)

The author presents pilot-symbol-assisted modulation (PSAM) on a solid analytical basis, a feature missing from previous work. Closed-form expressions are presented for the bit error rate (BER) in binary-phase-shift-keying (BPSK) and in quadrature-phase-shift-keying (QPSK), for a tight upper bound on the symbol error rate in 16 quadrature-amplitude-modulation (16-QAM), and for the optimized receiver coefficients. The error rates obtained are lower than for differential detection for any combination of signal-to-noise ratio (SNR) and Doppler spread, and the performance is within 1 dB of a perfect reference system under slow-fading conditions and within 3 dB when the Doppler spread is 5% of the symbol rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Multichannel Gray Level Co-Occurrence Matrix for Multi/Hyperspectral Image Texture Representation (2014)

This study proposes a novel method for multichannel image gray level co-occurrence matrix (GLCM) texture representation. It is well known that the standard procedure for the automatic extraction of GLCM textures is based on a mono-spectral image. In real applications, however, the GLCM texture feature extraction always refers to multi/hyperspectral images. The widely used strategy to deal with this issue is to calculate the GLCM from the first principal component or the panchromatic band, which do not include all the useful information. Accordingly, in this study, we propose to represent the multichannel textures for multi/hyperspectral imagery by the use of: (1) clustering algorithms; and (2) sparse representation, respectively. In this way, the multi/hyperspectral images can be described using a series of quantized codes or dictionaries, which are more suitable for multichannel texture representation than the traditional methods. Specifically, K-means and fuzzy c-means methods are adopted to generate the codes of an image from the clustering point of view, while a sparse dictionary learning method based on two coding rules is proposed to produce the texture primitives. The proposed multichannel GLCM textural extraction methods were evaluated with four multi/hyperspectral datasets: GeoEye-1 and QuickBird multispectral images of the city of Wuhan, the well-known AVIRIS hyperspectral dataset from the Indian Pines test site, and the HYDICE airborne hyperspectral dataset from the Washington DC Mall. The results show that both the clustering-based and sparsity-based GLCM textures outperform the traditional method (extraction based on the first principal component) in terms of classification accuracies in all the experiments.
Preparation and characterization of betulin nanoparticles for oral hypoglycemic drug by antisolvent precipitation (2014)

Abstract Betulin, a kind of small molecular compound, was reported that has hypoglycemic effect. Due to its low aqueous solubility and high permeability, betulin has low and variable oral bioavailability. In this work, betulin nanoparticles were thus prepared by antisolvent precipitation for accelerating dissolution of this kind of poorly water-soluble drugs. Ethanol was used as solvent and deionized water was used as antisolvent. The effects of various experimental parameters on the mean particle size (MPS) of nanocrystallization betulin were investigated. The MPS of betulin nanoparticles suspension basically remain unchanged when precipitation time was within 60 min and then increased from 304 nm to 505 nm later. However, the MPS of betulin nanoparticles suspension decreased with increased betulin solution concentration. On the contrary, the MPS of betulin nanoparticles suspension decreased along with the increase of temperature. Stirring intensity and the speed ratio of solvent adding into antisolvent had no significant influences on the MPS of betulin nanoparticles suspension. Betulin nanoparticles suspension with a MPS of approximately 110 nm was achieved under the optimal precipitation conditions. FTIR, Liquid chromatography coupled with tandem mass spectrometry (LC-MS), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were used to analyze the characteristic of betulin nanoparticles powder. These results show that betulin nanoparticles powder has the same chemical structure as raw drug, but a smaller size and lower crystallinity. The dissolution rate and solubility of betulin nanoparticles powder were separately 3.12 and 1.54 times of raw drug. The bioavailability of betulin nanoparticles powder increased 1.21 times compared with raw betulin. The result of in vivo evaluation on diabetic animals demonstrates that the betulin nanoparticles powder show an excellent hypoglycemic effect compared with raw betulin. In addition, the residual ethanol is less than the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human) limit for class 3 solvents of 5000 ppm or 0.5% for solvents.
A systematic review of sacral nerve stimulation for low anterior resection syndrome (2015)

The review suggests that SNS for faecal incontinence in LARS has success rates comparable to its use for other forms of faecal incontinence.
Anti‐Carbohydrate Antibodies for the Detection of Anthrax Spores (2006)

Sweet traitor: Monoclonal antibodies against a tetrasaccharide that contains the unique monosaccharide anthrose, which is found on the surface of B. anthracis spores, are used to selectively detect this biowarfare threat.
Highly Strained Cyclic Paraffin-Siloxanes (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHighly Strained Cyclic Paraffin-SiloxanesWilliam A. Piccoli, Gerald G. Haberland, and Robert L. MerkerCite this: J. Am. Chem. Soc. 1960, 82, 8, 1883–1885Publication Date (Print):April 1, 1960Publication History Published online1 May 2002Published inissue 1 April 1960https://pubs.acs.org/doi/10.1021/ja01493a012https://doi.org/10.1021/ja01493a012research-articleACS PublicationsRequest reuse permissionsArticle Views369Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis (2014)

NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted by SV40 transformation. In transformed but not primary murine embryonic fibroblasts, NLRX1 expression mediated resistance to an extrinsic apoptotic signal, whereas conferring susceptibility to intrinsic apoptotic signals, such as glycolysis inhibition, increased cytosolic calcium and endoplasmic reticulum stress. In a murine model of colorectal cancer induced by azoxymethane, NLRX1-/- mice developed fewer tumors than wild type mice. In contrast, in a colitis-associated cancer model combining azoxymethane and dextran sulfate sodium, NLRX1-/- mice developed a more severe pathology likely due to the increased sensitivity to dextran sulfate sodium colitis. Together, these results identify NLRX1 as a critical mitochondrial protein implicated in the regulation of apoptosis in cancer cells. The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions.
Molecular dynamics simulations of d(C-G-C-G-A) X d(T-C-G-C-G) with and without "hydrated" counterions. (1985)

We present the results of molecular dynamics simulations on d(C-G-C-G-A) X d(T-C-G-C-G) with fully charged phosphates with and without inclusion of counterions. The average structures found in the two simulations are similar, but the simulation with counterions does give an average helix repeat, tilt, and twist in better agreement with those found in the x-ray structure of d(C-G-C-G-A-A-T-T-C-G-C-G)2. The average sugar pucker phases and amplitudes are in qualitative agreement with those found in NMR studies of double-helical DNA, and a number of examples of sugar repuckering from C2' endo to C3' endo carbon conformations in the sugar ring are found. The hydrogen bond correlations as well as torsion correlations are analyzed, and some interesting long-range correlations between dihedral angles are found.
Evaluation of the sleepy crewmember: USAFSAM experience and a suggested clinical approach. (1989)

From 1958 to 1986, 27 crewmembers with suspected sleep disorders were referred to the USAF School of Aerospace Medicine. The presenting complaint in most cases was excessive daytime sleepiness (EDS). Prior to 1984, evaluations included neurologic and psychiatric testing, screening laboratory studies, and awake and asleep electroencephalography. Polysomnography and sleep latency studies were included after 1984. In the majority of cases, the etiology of the complaint could not be determined. The prevalence of EDS is estimated to be between 0.3% and 4.0% of the adult population. Major causes cited in the world literature include the sleep apnea syndromes, narcolepsy, parasomnias interrupting sleep, hypersomnia secondary to systemic or affective disorders, and essential hypersomnia. Current sleep lab techniques and human leukocyte antigen (HLA) typing are reported to make the diagnosis in up to 90% of sleep disorders. Evaluation of EDS should begin with a history emphasizing sleep habits, work schedules, daytime naps, and presence of vegetative signs. A sleep diary will allow a more accurate estimate of the quantity of nocturnal sleep. This diary may reveal poor sleep hygiene or insomnia. Polysomnography and/or multiple sleep latency determination can then be used to diagnose sleep apnea, parasomnias, and narcolepsy.
Block Adaptive Interpolation Filter Using Trained Dictionary for Sub-Pixel Motion Compensation (2011)

Adaptive interpolation filtering for sub-pel motion compensation is one of key techniques of ITU-T key technology area (KTA) codec. However, the adaptive interpolation filtering has a limitation in coding efficiency because of its frame-based update strategy of filter coefficients. Although switched interpolation filter with offset is presented as a sort of block-adaptive filtering for KTA codec, its coding efficiency is generally lower than that of the best adaptive interpolation filter. In order to overcome such a problem, this paper presents an advanced block-adaptive interpolation filtering using well-trained dictionaries which store optimized filter coefficients. We derive those filter coefficients by using learning-based super-resolution. The proposed block-adaptive interpolation filtering for quarter-pel motion compensation consists of two steps: up-scaling of half-pel accuracy and subsequent up-scaling of quarter-pel accuracy. The dictionary optimized for each step is employed to produce the precise up-scaled pixels. Simulation results show that the proposed algorithm improves higher coding efficiency than the previous adaptive interpolation filters for KTA.
Advances in the Synthesis of Heteroadamantanes (1976)

Typical formal schemes for the synthesis of heteroadamantane structures and the limits of applicability and synthetic scope of various methods are discussed and described systematically. The bibliography includes 207 references.
Increase of Cinnamaldehyde Groups in Lignin of Transgenic Tobacco Plants Carrying an Antisense Gene for Cinnamyl Alcohol Dehydrogenase (1995)

An antisense gene for Aralia cordata cinnamyl alcohol dehydrogenase (CAD) was introduced into tobacco plants. Two transgenic plants showed 55 and 20% reduction of the CAD activity compared to that of the control plant. Lignin content measured by the acetyl bromide method showed no significant differences between these plants and the control plant. However, the content of p-hydroxycinnamaldehyde groups in lignin was higher in the transgenic than in the control plants. The increase of p-hydroxycinnamaldehyde groups correlated inversely with the levels of CAD activity. Phloroglucinol staining of transverse sections of stem internode indicated that the fiber secondary wall reacted more strongly with the reagent in the transgenic plants. These results suggested that suppression of CAD activity in tobacco plants results in an increase of cinnamaldehyde groups in lignin, but no significant change in lignin content.
Super-resolution through neighbor embedding (2004)

In this paper, we propose a novel method for solving single-image super-resolution problems. Given a low-resolution image as input, we recover its high-resolution counterpart using a set of training examples. While this formulation resembles other learning-based methods for super-resolution, our method has been inspired by recent manifold teaming methods, particularly locally linear embedding (LLE). Specifically, small image patches in the lowand high-resolution images form manifolds with similar local geometry in two distinct feature spaces. As in LLE, local geometry is characterized by how a feature vector corresponding to a patch can be reconstructed by its neighbors in the feature space. Besides using the training image pairs to estimate the high-resolution embedding, we also enforce local compatibility and smoothness constraints between patches in the target high-resolution image through overlapping. Experiments show that our method is very flexible and gives good empirical results.
Plasmid required for virulence of Agrobacterium tumefaciens (1975)

The irreversible loss of crown gall-inducing ability of Agrobacterium tumefaciens strain C-58 during growth at 37 C is shown to be due to loss of a large plasmid (1.2 X 10-8 daltons). The gene responsible for this high rate of plasmid loss at elevated temperatures seems to be located on the plasmid. In addition, another spontaneous avirulent variant, A. tumefaciens strain IIBNV6 is shown to lack the virulence plasmid which its virulent sibling strain, IIBV7, possesses. Deoxyribonucleic acid reassociation measurements prove that the plasmid is eliminated, not integrated into the chromosome, in both of the avirulent derivatives. Transfer of virulence from donor strain C-58 to avirulent recipient strain A136 results from the transfer of a plasmid, which appears identical to the donor plasmid by deoxyribonucleic acid reassociation measurements. The transfer of virulence in another cross, K27 X A136, was also shown to result from the transfer of a large plasmid. These findings establish unequivocally that the large plasmid determines virulence. Two additional genetic determinants have been located on the virulence plasmid of A. tumefaciens strain C-58: the ability to utilize nopaline and sensitivity to a bacteriocin produced by strain 84. The latter trait can be exploited for selection of avirulent plasmid-free derivatives of strain C-58. The trait of nopaline utilization appears to be on the virulence plasmid also in strains IIBV7 and K27.