gebhart/patrepeval huggingface dataset:
Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. (1981)

In dispersed acini from guinea pig pancreas, proglumide (DL-4-benzamido-N, N-dipropylglutaramic acid) and benzotript (N-p-chlorobenzoyl-L-tryptophan) caused a rightward shift in the dose--response curve for cholecystokinin-stimulated amylase secretion but did not alter the maximal increase in amylase secretion caused by cholecystokinin. At relatively low concentrations, proglumide did not alter the stimulation of enzyme secretion caused by secretagogues whose effects are mediated by adenosine 3'5'-monophosphate (e.g., vasoactive intestinal peptide or secretin) and did not alter the stimulation of enzyme secretion caused by secretagogues that have a mode of action similar to that of cholecystokinin but act through different receptors (e.g., bombesin, physalaemin, eledoisin, and ionophore A23187). There was a close correlation between the ability of proglumide or benzotript to inhibit binding of 125I-labeled cholecystokinin to its receptors on pancreatic acini and the abilities of these compounds to inhibit the action of cholecystokinin on enzyme secretion and on calcium outflux. These results indicate that proglumide and benzotript are members of a different class of cholecystokinin receptor antagonists.
Concatenated polar codes based on selective polarization (2015)

In this paper, we propose a selectively polarized concatenation structure for polar codes. We first divide the polarized bit-channels into three types, i.e., good, intermediate and bad bit-channels according to their Bhattacharyya parameter. Then, through combining several information blocks, the intermediate bit-channels are further polarized to enhance polarization rate. Theoretical and numerical results indicate that the proposed scheme achieves the same capacity as original polar codes at the same length, while the bit error rate (BER) performance is better than that of original polar codes as same decoding delay is considered. The polar codes can be used in the cognitive radio system.
Intranasal lidocaine for migraine and cluster headaches. (1997)

While lidocaine may not be effective for the relief of all cluster or migraine headaches and the pain may recur in some patients, this therapy may offer an important therapeutic alternative for certain migraine patients. Further research may provide more information, such as which headache types best respond to lidocaine, if higher concentrations of lidocaine are more effective, if lidocaine solution is more effective than lidocaine nose spray, and if other local anesthetics are as effective.
Field effects in nematic liquid crystals obtained with interdigital electrodes (1974)

New electro-optic effects in nematic liquid crystals have been found with a gratinglike array of in-plane interdigital electrodes. High-contrast light valving has been demonstrated in a tunable optical-activity mode and in two tunable birefringence modes. All three field-effect modes utilized a positive-dielectric-anisotropy nematic liquid crystal. Proposals are made for applying the interdigital technique to cholesteric, smectic, and mixed liquid-crystal systems. Experimental results indicate that the comb-shaped electrodes are valuable in a variety of display devices.
Mutation of the ATP-Binding Pocket of SSA1 Indicates That a Functional Interaction Between Ssa1p and Ydj1p Is Required for Post-translational Translocation Into the Yeast Endoplasmic Reticulum (2000)

The translocation of proteins across the yeast ER membrane requires ATP hydrolysis and the action of DnaK (hsp70) and DnaJ homologues. In Saccharomyces cerevisiae the cytosolic hsp70s that promote post-translational translocation are the products of the Ssa gene family. Ssa1p maintains secretory precursors in a translocation-competent state and interacts with Ydj1p, a DnaJ homologue. Although it has been proposed that Ydj1p stimulates the ATPase activity of Ssa1p to release preproteins and engineer translocation, support for this model is incomplete. To this end, mutations in the ATP-binding pocket of SSA1 were constructed and examined both in vivo and in vitro. Expression of the mutant Ssa1p's slows wild-type cell growth, is insufficient to support life in the absence of functional Ssa1p, and results in a dominant effect on post-translational translocation. The ATPase activity of the purified mutant proteins was not enhanced by Ydj1p and the mutant proteins could not bind an unfolded polypeptide substrate. Our data suggest that a productive interaction between Ssa1p and Ydj1p is required to promote protein translocation.
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. (1998)

The budding yeast gene product, CDC53p, forms E3-like SCF complexes with SKP1 and F-box-containing proteins to mediate the ubiquitin-dependent degradation of G1 cyclins and cyclin-dependent kinase (CDK) inhibitors. Cdc53 represents a multigene family, the human homologues of which, the cullin family, include at least six distinct members. We have found that human cullin 1, but not the other closely related cullins 2, 3, 4A, and 5, selectively interacts with human SKP1. This CUL1-SKP1 interaction is mediated by the NH2-terminal domains of both proteins, and the association appears to be required for the interaction of CUL1 with SKP2, an essential element of the S-phase cyclin A-CDK2 kinase. In an asynchronous population of dividing cells, a minor amount of CUL1 specifically associates with cyclin A but not with other cyclins or CDK inhibitors. The steady-state levels of both CUL1 and SKP1 as well as their association with one another remain relatively constant throughout the cell cycle and in postmitotic cells. Our findings indicate that the SCF pathway, although similarly used by the mammalian cullin 1, is not shared by other cullin members. This implies that most cullins may use a SKP1/F-box-independent pathway to facilitate protein degradation.
Propagating Updates in SPIDER (2007)

SPIDER, developed at AT&T Labs-Research, is a system that efficiently supports flexible string matching against attribute values in large databases, and is extensively used in AT&T. The scoring methodology is based on tf.idf weighting and cosine similarity, and SPIDER maintains indexes containing string tokens and their weights, for fast matching at query time. Given the "global" nature of the weights maintained in the indexes, even a few updates to the underlying database tables would necessitate a (near-complete recomputation of the indexes, which can be prohibitively expensive. In this paper, we explore novel techniques to considerably reduce the cost of propagating updates in SPIDER, without a significant degradation of answer accuracy or query performance. We present experimental evidence using real data sets to demonstrate the practical benefits of our techniques.
Robust tuning of power system stabilizers in multimachine power systems (2000)

This paper demonstrates the robust tuning of power systems stabilizers for power systems, operating at different loading conditions. A classical lead-lag power system stabilizer is used to demonstrate the technique. The problem of selecting the stabilizer parameters is converted to a simple optimization problem with an eigenvalue-based objective function, which is solved by a tabu search algorithm. The objective function allows the selection of the stabilizer parameters to optimally place the closed-loop eigenvalues in the left-hand side of a vertical line in the complex s-plane. The effectiveness of the stabilizers tuned using the suggested technique, in enhancing the stability of power systems, is confirmed through eigenvalue analysis and simulation results.
Supporting stored video: reducing rate variability and end-to-end resource requirements through optimal smoothing (1998)

Variable-bit-rate (VBR) compressed video can exhibit significant multiple-time-scale bit-rate variability. In this paper we consider the transmission of stored video from a server to a client across a network, and explore how the client buffer space can be used most effectively toward reducing the variability of the transmitted bit rate. Two basic results are presented. First, we show how to achieve the greatest possible reduction in rate variability when sending stored video to a client with given buffer size. We formally establish the optimality of our approach and illustrate its performance over a set of long MPEG-1 encoded video traces. Second, we evaluate the impact of optimal smoothing on the network resources needed for video transport, under two network service models: deterministic guaranteed service (Chang 1994; Wrege et al. 1996) and renegotiated constant-bit-rate (RCBR) service (Grossglauser et al. 1997). Under both models, the impact of optimal smoothing is dramatic.
Learning to transform natural to formal languages (2005)

This paper presents a method for inducing transformation rules that map natural-language sentences into a formal query or command language. The approach assumes a formal grammar for the target representation language and learns transformation rules that exploit the non-terminal symbols in this grammar. The learned transformation rules incrementally map a natural-language sentence or its syntactic parse tree into a parse-tree for the target formal language. Experimental results are presented for two corpora, one which maps English instructions into an existing formal coaching language for simulated RoboCup soccer agents, and another which maps English U.S.-geography questions into a database query language. We show that our method performs overall better and faster than previous approaches in both domains.
The Lipogenesis Pathway as a Cancer Target (2011)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTThe Lipogenesis Pathway as a Cancer TargetHanley N. Abramson*View Author Information Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, Michigan 48201, United StatesPhone: 1-313-577-1711. Fax: 1-313-577-2033. E-mail: [email protected]Cite this: J. Med. Chem. 2011, 54, 16, 5615–5638Publication Date (Web):July 1, 2011Publication History Received9 May 2011Published online3 August 2011Published inissue 25 August 2011https://pubs.acs.org/doi/10.1021/jm2005805https://doi.org/10.1021/jm2005805review-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views5521Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Cells,Inhibitors,Lipids,Peptides and proteins Get e-Alerts
Odorant-Binding Proteins (1994)

Odorant-binding proteins (OBPs) are low-molecular-weight soluble proteins highly concentrated in the nasal mucus of vertebrates and in the sensillar lymph of insects. Their affinity toward odors and pheromones suggests a role in olfactory perception, but their physiological function has not been clearly defined. Several members of this class of proteins have been isolated and characterized both in insects and vertebrates; in most species two or three types of OBPs are expressed in the nasal area. Vertebrates OBPs show significant sequence similarity with a superfamily of soluble carrier proteins called lipocalins. They include some proteins of particular interest that are thought to be involved in the mechanism of releasing and modulating chemical messages with pheromonal activity. The data on vertebrate OBPs are here reviewed together with the most relevant information on related proteins. Theories and models of the physiological functions of odorant-binding proteins are presented and discussed.
Histologic Variations in Juvenile Polyp Phenotype Correlate With Genetic Defect Underlying Juvenile Polyposis (2011)

Juvenile polyps in the setting of JPS exhibit distinct phenotypes correlating with the underlying genetic defect.
Use of Plasma Procalcitonin Levels as an Adjunct to Clinical Microbiology (2010)

Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid, specific, and of sufficient sensitivity to detect increases in PCT serum levels within 4 to 6 h of initiation of infection. Clinically, PCT levels may help in decisions regarding the need for empirical antibiotic therapy, "source control" of infection, and duration of antibiotic therapy. The addition of PCT levels to bacterial culture and viral detection results can assist with the separation of colonization and invasion by pathogenic bacteria.
Patterned library analysis: A method for the quantitative assessment of hypotheses concerning the determinants of protein structure (1999)

Site-directed mutagenesis and combinatorial libraries are powerful tools for providing information about the relationship between protein sequence and structure. Here we report two extensions that expand the utility of combinatorial mutagenesis for the quantitative assessment of hypotheses about the determinants of protein structure. First, we show that resin-splitting technology, which allows the construction of arbitrarily complex libraries of degenerate oligonucleotides, can be used to construct more complex protein libraries for hypothesis testing than can be constructed from oligonucleotides limited to degenerate codons. Second, using eglin c as a model protein, we show that regression analysis of activity scores from library data can be used to assess the relative contributions to the specific activity of the amino acids that were varied in the library. The regression parameters derived from the analysis of a 455-member sample from a library wherein four solvent-exposed sites in an alpha-helix can contain any of nine different amino acids are highly correlated (P < 0.0001, R(2) = 0. 97) to the relative helix propensities for those amino acids, as estimated by a variety of biophysical and computational techniques.
The regulation of Acinetobacter sp. α-oxoglutarate dehydrogenase complex (1972)

Research Article| November 01 1972 The regulation of Acinetobacter sp. α-oxoglutarate dehydrogenase complex M G Parker; M G Parker 1Department of Biochemistry, University of Leicester, Leicester LE1 7RH, U.K. Search for other works by this author on: This Site PubMed Google Scholar P D Weitzman P D Weitzman 1Department of Biochemistry, University of Leicester, Leicester LE1 7RH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1972) 130 (1): 39P. https://doi.org/10.1042/bj1300039Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M G Parker, P D Weitzman; The regulation of Acinetobacter sp. α-oxoglutarate dehydrogenase complex. Biochem J 1 November 1972; 130 (1): 39P. doi: https://doi.org/10.1042/bj1300039Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1972 The Biochemical Society1972 Article PDF first page preview Close Modal You do not currently have access to this content.
A Central Role for -Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in 2-Adrenergic Receptor Resensitization (1997)

G protein-coupled receptor (GPCR) sequestration to endosomes is proposed to be the mechanism by which G protein-coupled receptor kinase (GRK)-phosphorylated receptors are dephosphorylated and resensitized. The identification of beta-arrestins as GPCR trafficking molecules suggested that beta-arrestins might represent critical determinants for GPCR resensitization. Therefore, we tested whether beta2-adrenergic receptor (beta2AR) resensitization was dependent upon beta-arrestins and an intact clathrin-coated vesicle endocytic pathway. The overexpression of either the beta-arrestin 1-V53D dominant negative inhibitor of beta2AR sequestration or dynamin I-K44A to block clathrin-coated vesicle-mediated endocytosis impaired both beta2AR dephosphorylation and resensitization. In contrast, resensitization of a sequestration-impaired beta2AR mutant (Y326A) was reestablished following the overexpression of either GRK2 or beta-arrestin 1. Moreover, beta2ARs did not resensitize in COS-7 cells as the consequence of impaired sequestration and dephosphorylation. However, beta2AR resensitization was restored in these cells following the overexpression of beta-arrestin 2. These findings demonstrate, using both loss and gain of function paradigms, that beta2AR dephosphorylation and resensitization are dependent upon an intact sequestration pathway. These studies also indicate that beta-arrestins play an integral role in regulating not only the desensitization and intracellular trafficking of GPCRs but their ability to resensitize. beta-Arrestin expression levels appear to underlie cell type-specific differences in the regulation of GPCR resensitization.
Left definite Sturm-Liouville problems with eigenparameter dependent boundary conditions (1999)

In this paper we continue our study of the second order linear equation (py 0 ) 0 + qy = ry on [0, 1], where p > 0, 0 = d dx ,
Production and Characterization of Monoclonal Antibodies Directed against the Laminin Receptor Precursor (1997)

The 67-kDa laminin receptor (67LR) is an important tumor marker whose molecular structure has not yet been fully elucidated. To shed new light on this molecule, we raised a series of eight new monoclonal antibodies, designated MPLR1 to 8, directed against the 37-kDa recombinant laminin receptor precursor (37LRP). Cross-competition experiments demonstrated that the epitopes recognized by MPLR2, 4 and 5 partially overlap, since MPLR4 and 5 compete with labelled MPLR2 for the binding to recombinant 37LRP. These three antibodies belong to the IgG1 class, whereas the other ones are all IgM. Presumably due to the fact that they are directed against partially unfolded antigenic determinants expressed on the recombinant protein, MPLRs did not recognize the native protein. Indeed, they showed no reactivity at the membrane level in cytofluorimetric analysis and they did not work in immunoprecipitation experiments. In contrast, these reagents are valuable tools in immunoblotting, since they clearly identify a 67-kDa protein (the mature laminin receptor) in addition to the 37-kDa precursor form. MPLRs are thus a new powerful tool which could help in the characterization of the still enigmatic 67LR molecule.
Prevention of Derailments Due to Concrete Tie Rail Seat Deterioration (2007)

Concrete tie rail seat abrasion/deterioration (RSA) has been an issue since the inception of concrete ties. As a result of recent derailments involving abraded concrete ties on curved track, the Federal Railroad Administration set up a task force to study abrasion/deterioration mechanisms and develop automated detection methods using existing research vehicles. A portion of this study reviews historical development of concrete abrasion due to moisture or foreign materials incorporated under the rail seat that tend to abrade concrete ties evenly across the rail seat area. This report discusses a newly identified concrete tie deterioration mechanism characterized by material loss in a triangle toward the field side of the rail seat, resulting from wheel rail interaction involving track geometry variations. The NUCARS™ model was used to evaluate the vertical and lateral loading at one of the recent derailment sites using the track geometry measured approximately one month before the derailment. Wheel loads predicted from the model, based on P-42 Amtrak Locomotive, were used to evaluate the pressure distribution at the rail concrete tie interface and were compared with allowable design bearing pressure for concrete used in the manufacture of concrete ties. The results indicate that applied stress on the field side of a concrete tie due to outward rail roll can exceed the design values. Applied pressure distribution exceeding the design strength on the field side tends to abrade concrete ties in a triangular wear pattern that produces wide gage. Charts were developed to convert measured field side abrasion/deterioration to additional gage widening under an applied vertical load for identifying critical locations with wide gage defects. Further, techniques for field inspectors to detect, measure, and evaluate rail seat abrasion/deterioration (RSA) based on commonly used inspection technology are discussed.
Mechanism of Visible Light Phototoxicity on Porphyromonas gingivalis and Fusobacterium nucleatum (2005)

ABSTRACT Phototoxicity of visible light laser on the porphyrin‐producing bacteria, Porphyromonas gingivalis , in the absence of photo‐sensitizers and under aerobic conditions was shown in previous studies. Recently, we found that the noncoherent visible light sources at wavelengths of 400–500 nm, commonly used in restorative dentistry, induced a phototoxic effect on P. gingivalis , as well as on Fusobacterium nucleatum , and to a lesser extent on the Streptococci sp. To elucidate the mechanism of this phototoxic effect, P. gingivalis and F. nucleatum were exposed to light ( 1 ) under aerobic and anaerobic environments and ( 2 ) in the presence of scavengers of reactive oxygen species (ROS). Phototoxic effect was not observed when the bacteria were exposed to light under anaerobic conditions. Dimethyl thiourea, a hydroxyl radical scavenger, was effective in reducing phototoxicity ( P 0.05). Other scavengers, such as catalase, superoxide dismutase and ascorbic acid, were less effective when applied separately. These results support the assumption that the phototoxic effect of blue light on the periopathogenic bacteria is oxygen dependent and that hydroxyl radicals play an important role in this process.
Proteins from the D‐Chiral World (1992)

The chiroptical properties and substrate specificity of the D ‐enantiomer of the naturally occurring HIV protease synthesized by Kent et al. demonstrate that the three‐dimensional structures of D ‐ and L ‐enzymes really are mirror images of one another—that is, identical amino acid sequences actually fold in the same way in the tertiary structure. Interest in D ‐proteins goes beyond basic research, as the enzymatic stability may allow important medical applications; additional areas of application include protein crystallography.