gebhart/patrepeval huggingface dataset:
<title>Preparation and characterization of poly (ethylene glycol)-coated Stoeber silica nanoparticles for biomedical applications</title> (2002)

Monodisperse, spherical, polyethylene glycol (PEG)-coated silica nanoparticles have been prepared in the size range of 50-350 nm, and their size distribution were characterized by SEM and multi-angle static light scattering experiments. The chemical binding of PEG to the silica nanoparticles was confirmed by IR spectroscopy. The biocompatibility of these PEGylated nanoparticles was also studied by non-specific protein binding tests and in-vivo toxicology studies in live animals. These silica nanoparticles, as a matrix for encapsulation of certain reagents, have been used for the fabrication of intracellular sensors and have potential for applications to in vivo diagnosis, analysis and measurements, due to their small physical size and their biocompatibility, both stemming from the specialized PEG coating.
Taking aim at translation for tumor therapy (2007)

Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antisense oligonucleotides for eIF4E (see the related article beginning on page 2638). If their results are recapitulated in a clinical setting, this strategy will provide a promising antitumor therapy with broad-reaching applications.
Portable acoustic myography - a realistic noninvasive method for assessment of muscle activity and coordination in human subjects in most home and sports settings (2013)

Muscle sound gives a local picture of muscles involved in a particular movement and is independent of electrical signals between nerve and muscle. Sound recording (acoustic myography) is a well-known noninvasive technique that has suffered from not being easily applicable, as well as not being able to register at sufficient sampling speed. With modern amplifiers and digital sound recording this has changed, and such assessment during movement outside a laboratory setting may be possible. Our aim was to develop a setup for muscle-sound assessment, which could be reliably applied in any local setting. A group of healthy subjects were assessed during standing, stair climbing, walking, and running. Piezoelectric microphones were applied to the skin using contact gel. A digital sound recorder enabled sampling speeds of around 96,000 Hz. Surface electromyography was measured in parallel as a comparison. The recorded signals were assessed and described in terms of signal frequency (Hz) and peak-to-peak amplitude (mV) using Chart software. Bioimpedance of the involved muscles was measured. Sound recording was shown to be an easy noninvasive method for assessment of muscle function during movement with the possibility of being applied in most clinical, sports, and home settings. Muscle sound gives a representation of the work of each muscle group during a complex movement, illustrated here by a step test, which revealed both concentric and eccentric activity. The method in the presented new setup has great potential for assessment of function in patients with musculoskeletal complaints in out-of-clinic settings, as well as in sports.
Real-time human face detection in color image (2004)

In this paper, we employed a new approach to detect human faces in color images. A binary skin color map is firstly obtained by applying the skin/non-skin classification algorithm, and then the integral image representation is used to preprocess the skin and intensity map. Thereafter, the refined skin areas are selected from input image for further detection. In the next processing, an intensity distribution model, which can be calculated on integer image very quickly, is used to decide whether the selected skin area contains a face candidate or not. In the possible face areas a new approach is designed to locate eyes accurately. Based on the positions of eyes, the other facial features are located and then the geometrical information of all facial features is used to further verify human face. Experiment results show the proposed method can successfully detect the frontal human faces with a wide range of variations in color, lighting, scale and expression from color image with complex backgrounds.
Active phased array technology using coplanar packaging technology (1995)

Until the present time, active phased array antennas have utilized individually packaged transmit/receive (T/R) modules which provide both transmitter and receiver functions on /spl lambda//2 wavelength centers. Such modules usually contain five to seven individual GaAs circuits which provide the following functions: transmit amplifier; phase shifter; variable attenuator; T/R switch; and low noise amplifier. This paper describes some recent efforts to eliminate the fabrication of individual modules and to incorporate other functions to multiply fabricated T/R cell paths including: circulator; radiating element; and signal manifolding. Efforts to date have centered on the 2-20 GHz portion of the spectrum and at Ka-band. An experimental test of a 16-element subarray is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Quantitative protein expression and cell surface characteristics of Escherichia coli MG1655 biofilms (2010)

Cell surface physicochemical characterization techniques were combined with quantitative changes in protein expression, to investigate the biological and biophysical changes of Escherichia coli MG1655 cells when grown as a biofilm (BIO). The overall surface charge of BIO cells was found to be less negative, highlighting the need for a lower electrophoretic mobility for attachment to occur. Comparison of the chemical functional groups on the cell surface showed similar profiles, with the absorbance intensity higher for proteins and carbohydrates in the BIO cells. Quantitative proteomic analysis demonstrated that 3 proteins were significantly increased, and 9 proteins significantly decreased in abundance, in cells grown as a BIO compared to their planktonic counterparts, with 7 of these total 12 proteins unique to this study. Proteins showing significant increased or decreased abundance include proteins involved in acid resistance, DNA protection and binding and ABC transporters. Further predictive analysis of the metabolic pathways showed an increased abundance of the amino acid metabolism and tricarboxylic acid (TCA) cycle, with a decrease in expression within the pentose phosphate and glycolysis pathways. It is therefore hypothesized that cells grown as a BIO are still energetically viable potentially using amino acids as an indirect carbon backbone source into the TCA cycle.
[Drug-induced parkinsonian syndromes: a 10-year experience at a regional center of pharmaco-vigilance]. (1994)

Besides classical neuroleptics, several drugs can induce parkinsonian symptoms. The present retrospective study investigates the characteristics of drug-induced parkinsonism notified to the Midi-Pyrénées Pharmacovigilance Centre between 1983 and 1992. Among 3,923 side effects spontaneously reported between 1983 and 1992 to the center, 53 (1.4%) were drug-induced parkinsonism. Mean age was 65 +/- 2 (s.e.m.) years (range 21-88). Drug-induced parkinsonism appeared after a mean treatment duration of 473 +/- 142 days (range 1 day to 15 years) and occurred most frequently in women (63%). The occurrence onset of drug-induced Parkinsonism exhibited a bimodal pattern with a first peak (between 0 and 6 months) mainly due to peripheral or central antidopaminergic drugs and a second one later (between 9 and 12 months) due mostly to calcium channel blockers. Involved drugs were mostly antidopaminergic agents: neuroleptics (antipsychotic drugs: 39%) but also agents used for nausea or vomiting (domperidone, metoclopramide, metopimazine or triethylperazine: 12%) or symptoms associated with menopause (veralipride: 6%). Other cases were related mainly to drugs with "calcium channel blocker" properties (flunarizine and cinnarizine: 30%), H1 antihistamine (1 case), fluoxetine (1 case), alphamethyldopa (1 case) or reserpine (1 case) whereas 3 cases were due to drug interactions. Imputability scores (according to the method of assessment of unexpected drug reactions used in France) were "doubtful" (11%), "plausible" (34%) and "probable" (53%). The complete triad (tremor, akinesia plus rigidity) was seen in 13 (25%) cases. Symmetrical symptoms occurred in 41 (77%) patients. A total disappearance of the clinical feature occurred in 39 (74%) patients whereas in 8 cases (15%), drug-induced parkinsonism led to the diagnosis of underlying idiopathic Parkinson's disease. The present study shows that around 80% of drug-induced parkinsonism are due to two pharmacological classes: central and peripheral antidopaminergic agents and calcium channel blockers.
Diyl Trapping and Electroreductive Cyclization Reactions (1996)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiyl Trapping and Electroreductive Cyclization ReactionsR. Daniel LittleView Author Information Department of Chemistry, University of California, Santa Barbara, Santa Barbara, California 93106 Cite this: Chem. Rev. 1996, 96, 1, 93–114Publication Date (Web):February 1, 1996Publication History Received28 July 1995Revised3 October 1995Published online1 February 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/cr950017dhttps://doi.org/10.1021/cr950017dresearch-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1538Altmetric-Citations103LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adducts,Cyclization,Diimides,Hydrocarbons,Organic compounds Get e-Alerts
Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients (2008)

Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response.
30 GHz tuned MEMS switches (2003)

This paper demonstrates the use of resonant tuning in high-isolation reflective MEMS electrostatic switches. Tuned switches can achieve higher isolation and a lower pulldown voltage than a comparable single element switch. An equivalent circuit model was developed for individual shunt capacitive membrane switches and then implemented in tuned circuits. The novel cross switch was developed on a high resistivity silicon. The cross switch attained an insertion loss of less than 0.6 dB and a return loss below -20 dB from 22-38 GHz in the up-state, and a down-state isolation of 50 dB with only 1.1 pF of down-state capacitance (Cd) per element. The pulldown voltage is 15-20 V, which is much better than typical industry numbers of 28-50 V. Application areas are low-loss high-isolation communication switches at 28 GHz and automotive switches at 77 GHz.
THE TUMOR SUPPRESSOR GENES (1993)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Molecular Basis of Recognition of Human Osteopontin by 23C3, a Potential Therapeutic Antibody for Treatment of Rheumatoid Arthritis (2008)

Osteopontin plays an important role in the development and perpetuation of rheumatoid arthritis (RA). Antibodies targeting osteopontin have shown promising therapeutic benefits against this disease. We have previously reported a novel anti-RA monoclonal antibody, namely, 23C3, and shown it capable of alleviating the symptoms of RA in a murine collagen-induced arthritis model, restoring the cytokine production profile in joint tissues, and reducing T-cell recall responses to collagen type II. We describe here the crystal structure of 23C3 in complex with its epitope peptide. Analyses of the complex structure reveal the molecular mechanism of osteopontin recognition by 23C3. The peptide folds into two tandem beta-turns, and two key residues of the peptide are identified to be critical for the recognition by 23C3: TrpP43 is deeply embedded into a hydrophobic pocket formed by AlaL34, TyrL36, LeuL46, TyrL49, PheL91, and MetH102 and therefore has extensive hydrophobic interactions with 23C3, while AspP47 has a network of hydrophilic interactions with residues ArgH50, ArgH52, SerH53, and AsnH56 of the antibody. Besides the complementarity-determining region loops, the framework region L2 of 23C3 is also shown to interact with the epitope peptide, which is not common in the antibody-antigen interactions and thus could be exploited in the engineering of 23C3. These results not only provide valuable information for further improvement of 23C3 such as chimerization or humanization for its therapeutic application, but also reveal the features of this specific epitope of osteopontin that may be useful for the development of new antibody drugs against RA.
cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. (1988)

The monoamine oxidases play a vital role in the metabolism of biogenic amines in the central nervous system and in peripheral tissues. Using oligonucleotide probes derived from three sequenced peptide fragments, we have isolated cDNA clones that encode the A and B forms of monoamine oxidase and have determined the nucleotide sequences of these cDNAs. Comparison of the deduced amino acid sequences shows that the A and B forms have subunit molecular weights of 59,700 and 58,800, respectively, and have 70% sequence identity. Both sequences contain the pentapeptide Ser-Gly-Gly-Cys-Tyr, in which the obligatory cofactor FAD is covalently bound to cysteine. Based on differences in primary amino acid sequences and RNA gel blot analysis of mRNAs, the A and B forms of monoamine oxidase appear to be derived from separate genes.
Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura (2018)

A 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the first case report of TNF- and IL-6-producing aggressive HGBL, NOS in the pleura, in which radiological findings mimicked pleural mesothelioma. The aggressive tumor progression in the present case may have been caused by abnormal cytokine production from lymphoma cells.
Efficacy of a Phosphorodiamidate Morpholino Oligomer Antisense Compound in the Inhibition of Corneal Transplant Rejection in a Rat Cornea Transplant Model (2011)

Graft rejection was significantly delayed after pretransplantation storage of graft corneas in Optisol containing AVI-5126 followed by topical application of AVI-5126 post-transplantation. AVI-5126 was well tolerated, stable, and effectively penetrated the cornea.
Scalable layered space-time codes for wireless communications: performance analysis and design criteria (2003)

Dual antenna-array systems provide very high capacity compared to single antenna systems in a Rayleigh fading environment. If the transmitter does not have the channel state information, to utilize this high capacity, space-time codes must be employed. The diagonally-layered space-time (DLST) architecture is a structure that is capable of providing a high data rate for a low decoding complexity. We analyze the performance of DLST codes with a hard decision-feedback decoder and a soft decision-feedback decoder with iterative decoding. We analyze the error probability performance and propose the criteria for designing the constituent codes.
Arthroscopic Offset Restoration in Femoroacetabular Cam Impingement: Accuracy and Early Clinical Outcome (2007)

Level IV, therapeutic case series.
Responsive planning (2007)

Detailed observation and assessment are essential practices for all early years practitioners if planning is to be responsive to young children's learning requirements, as Estelle Martin explains.
Effects of Statin Therapy According to Plasma High-Sensitivity C-Reactive Protein Concentration in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) (2009)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00206310.
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice (2003)

Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid reamplification in obesity and the metabolic syndrome has been suggested. The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regenerates active cortisol from inactive 11-keto forms, and aP2-HSD1 mice with relative transgenic overexpression of this enzyme in fat cells develop visceral obesity with insulin resistance and dyslipidemia. Here we report that aP2-HSD1 mice also have high arterial blood pressure (BP). The mice have increased sensitivity to dietary salt and increased plasma levels of angiotensinogen, angiotensin II, and aldosterone. This hypertension is abolished by selective angiotensin II receptor AT-1 antagonist at a low dose that does not affect BP in non-Tg littermates. These findings suggest that activation of the circulating renin-angiotensin system (RAS) develops in aP2-HSD1 mice. The long-term hypertension is further reflected by an appreciable hypertrophy and hyperplasia of the distal tubule epithelium of the nephron, resembling salt-sensitive or angiotensin II-mediated hypertension. Taken together, our findings suggest that overexpression of 11beta-HSD1 in fat is sufficient to cause salt-sensitive hypertension mediated by an activated RAS. The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder.
Proviral integration site 2 is required for interleukin‐6 expression induced by interleukin‐1, tumour necrosis factor‐α and lipopolysaccharide (2010)

PIM (proviral integration site) kinases are a distinct class of serine/threonine-specific kinases consisting of PIM1, PIM2 and PIM3. PIM2 is known to function in apoptosis pathways. Expression of PIM2 is highly induced by pro-inflammatory stimuli but the role of PIM2 in the expression of pro-inflammatory cytokines is unclear. In this study, we showed that over-expression of PIM2 in HeLa cells as well as in human umbilical vein endothelial cells enhanced interleukin-1β (IL-1β) -induced and tumour necrosis factor-α-induced IL-6 expression, whereas over-expression of a kinase-dead PIM2 mutant had the opposite effect. Studies with small interfering RNA specific to PIM2 further confirmed that IL-6 expression in HeLa cells requires PIM2. To investigate the function of PIM2 further, we generated PIM2-deficient mice. It was found that IL-6 production was significantly decreased from PIM2-deficient spleen cells after stimulation with lipopolysaccharide. Taken together, we demonstrated an important function of PIM2 in controlling the expression of the pro-inflammatory cytokine IL-6. PIM2 inhibitors may be beneficial for IL-6-mediated diseases such as rheumatoid arthritis.
Biologic Therapies in Clinical Development for the Treatment of Rheumatoid Arthritis (2005)

The therapeutic objective in patients with rheumatoid arthritis (RA) is reduction of disease activity with an ultimate goal of disease remission. Limitations of currently available disease-modifying antirheumatic drugs and biologic therapies suggest that there remains an unmet need for agents that advance these goals in a greater proportion of patients. Progress in our understanding of the regulatory molecules and pathways that mediate the immune and inflammatory responses necessary for the initiation and perpetuation of RA has led to the identification of new targets for therapy. It is expected that the therapeutic modulation of these targets, which include proinflammatory cytokines, T and B cells, adhesion molecules, chemokines, and intra- and extracellular signaling pathways, can provide new treatment strategies in patients with RA and other autoimmune disorders. Toward this end, a series of novel agents with diverse mechanisms of action are in development. Although many of these agents are still beyond the clinical horizon, several of them have shown promise in recent trials. This article reviews a few of the many treatment strategies currently being evaluated, which are hoped to lead to greater benefits and better disease management in the clinical setting.
<title>Microchannel Spatial Light Modulator As A Storage Medium</title> (1979)

The Microchannel spatial light modulator is an optically-addressed spatial light modulator that is being developed for low-light-level, real-time, optical signal processing. In addition to its framed or continuous real-time mode of operation, it can also be used for short-time (hours), low resolution (less than 20 cycles/mm) optical information storage. In this Paper we describe the structure of the device, its principles of operation, some of its preliminary characteristics, and the first attempts at optical information storage.
Electroosmotic Capillary Flow with Nonuniform Zeta Potential (2000)

The present work is an analytical and experimental study of electroosmotic flow (EOF) in cylindrical capillaries with nonuniform wall surface charge (zeta-potential) distributions. In particular, this study investigates perturbations of electroosmotic flow in open capillaries that are due to induced pressure gradients resulting from axial variations in the wall zeta-potential. The experimental inquiry focuses on electroosmotic flow under a uniform applied field in capillaries with an EOF-suppressing polymer adsorbed onto various fractions of the total capillary length. This fractional EOF suppression was achieved by coupling capillaries with substantially different zeta-potentials. The resulting flow fields were imaged with a nonintrusive, caged-fluorescence imaging technique. Simple analytical models for the velocity field and rate of sample dispersion in capillaries with axial zeta-potential variations are presented. The resulting induced pressure gradients and the associated band-broadening effects are of particular importance to the performance of chemical and biochemical analysis systems such as capillary electrokinetic chromatography and capillary zone electrophoresis.