gebhart/patrepeval huggingface dataset:
What we know about outsourcing (2007)

A common refrain of scholars of management and many other areas is the lack of literature in the area they study in order to legitimize their own research. For outsourcing, such claims can no longer be valid. A search of the Business Source Premier database on the keyword “outsourcing” generated a staggering 2,669 peer-reviewed articles using outsourcing in their titles, keywords, or abstracts, 917 of which were published in 2004 and 2005 alone. In the non-peer-reviewed category a further 19,364 articles appeared. Furthermore the Library of Congress holds 337 books and documents for which outsourcing is a keyword. Outsourcing, in short, is a hot topic academically. Clearly, in the presence of such a plethora of writings, any claim to newness cannot be based on having found an understudied topic. As the necessarily incomplete review of the literature contained within this chapter shows, many of the sub-areas of outsourcing are now quite populated with research studies as well. Carving out an original research contribution has, therefore, not become any easier over the years. In this chapter I will first look at some of the advantages and disadvantages of outsourcing as the literature has discussed them. This is followed by an investigation of the various business functions on which outsourcing research has focused. Then I will talk about what knowledge the study of various countries and industries has produced for our understanding of how context affects outsourcing.
Surgical Treatment of Adjacent Instability After Lumbar Spine Fusion (2001)

Autogenous posterolateral arthrodesis combined with pedicle screw fixation led to successful radiologic and clinical outcome in patients with lumbar adjacent instability. Adequate decompression of the adjacent stenosis requires medial facetectomy, thus preventing aggressive nerve root manipulation and reducing the incidence of dural tear.
Hemostatic Agents Derived from Chitin and Chitosan (2005)

Abstract A recent review detailing the role of new hemostatic agents for battlefield hemorrhage control describes the interest in and necessary specifications for such materials. As a consequence, the Defense Department authorized the development and use of three deployable and FDA approved hemostatic agents: Zeolite "Quikclot" and chitosanic "Hemcon" and the American Red Cross Fibrin Dressing. Although chitosan has a number of advantages over the other hemostatic agents, it is the least understood of the three agents noted above. The use of chitosan and chitin in different physical forms as a hemostatic agent is described. The chemical properties of chitosan related to hemostatis possibly include: molecular weight, extent of ionization, counter ion, degree of deacetylation, and degree of crystallinity. Also, its ability to bind with tissues are a function of these parameters. Chitosan can be used in medical and surgical procedures by its direct application to a bleeding surface using the various physical forms such as powder, solution, coating, film, hydrogel, and filament composite. Keywords: chitinchitosanhemostatichydrogelfilmfiber
Design Optimization of Field Emission From A Stacked Carbon Nanotube Array (2008)

Fluctuation of field emission in carbon nanotubes (CNTs) is riot desirable in many applications and the design of biomedical x-ray devices is one of them. In these applications, it is of great importance to have precise control of electron beams over multiple spatio-temporal scales. In this paper, a new design is proposed in order to optimize the field emission performance of CNT arrays. A diode configuration is used for analysis, where arrays of CNTs act as cathode. The results indicate that the linear height distribution of CNTs, as proposed in this study, shows more stable performance than the conventionally used unifrom distribution.
Phosphorothioate-containing RNAs show mRNA activity in the prokaryotic translation systemsin vitro (1991)

Phosphorothioate-containing RNAs were generated by transcription of coliphage T7 DNA using the Sp diastereomers of ribonucleoside 5'-O-(1-thiotriphosphates) and T7 RNA polymerase. RNAs in which a single nucleotide was substituted by the corresponding nucleoside phosphorothioate functioned as mRNA in the cell-free translation systems prepared from Escherichia coli and from an extreme thermophilic bacterium, Thermus thermophilus. This substitution increased the efficiency of protein synthesis by stabilizing the mRNAs in these systems. As the proportion of substituted nucleotides was increased, their mRNA activity was decreased accordingly. As judged from the analysis by SDS-polyacrylamide gel-electrophoresis, the proteins synthesized using phosphorothioate-containing mRNAs as template were identical to those obtained with unsubstituted mRNAs. However, larger proteins which were barely detectable when unsubstituted mRNA was used were well represented when phosphorothioate-RNA was used instead. The advantages in using the phosphorothioate-mRNAs in the in vitro translation systems are discussed.
Preamble design for multiple-antenna OFDM-based WLANs with null subcarriers (2001)

The so-called orthogonal frequency division multiplexing (OFDM) technique has received considerable interest, especially in the area of wireless local area networks (WLANs). One way of meeting the demands for increased data rates in WLANs is to provide the transmitter and receiver with multiple antennas. In this letter, we consider the estimation of the channel and the design of optimal preambles (training sequences) for an OFDM system with two transmit and multiple receive antennas.
ChemInform Abstract: THE PREPARATION AND REACTIONS OF ESTERS OF DICHLOROMETHANEBORONIC ACID (1977)

Abstract Die aus Methylenchlorid (I), n‐Butyllithium (II) und Borsäuretrimethylester (IV) hergestellte Dichlormethanboronsäure (VI) wird zu den Estern (VII) umgesetzt, deren Reaktion mit metallorganischen Verbindungen untersucht wird.
Proximal spinal muscular atrophy: current orthopedic perspective (2013)

Spinal muscular atrophy (SMA) is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN) protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity and a high mortality and morbidity rate, recent advances in multidisciplinary supportive care have enhanced quality of life and life expectancy. Active research for possible treatment options has become possible since the disease-causing gene defect was identified in 1995. Nevertheless, a causal therapy is not available at present, and therapeutic management of SMA remains challenging; the prolonged survival is increasing, especially orthopedic, respiratory and nutritive problems. This review focuses on orthopedic management of the disease, with discussion of key aspects that include scoliosis, muscular contractures, hip joint disorders, fractures, technical devices, and a comparative approach of conservative and surgical treatment. Also emphasized are associated complications including respiratory involvement, perioperative care and anesthesia, nutrition problems, and rehabilitation. The SMA disease course can be greatly improved with adequate therapy with established orthopedic procedures in a multidisciplinary therapeutic approach.
Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. (1997)

Pemphigus vulgaris (PV) is a cutaneous autoimmune disease characterized by blister formation in the suprabasilar layers of skin and mucosae and anti-desmoglein-3 (Dsg3) autoantibodies bound to the surface of lesional keratinocytes and circulating in the serum of patients. This disease can be reproduced in neonatal mice by passive transfer of patients' IgG, indicating that humoral immunity plays an important role in the pathogenesis of PV. Currently, the role of T lymphocytes in the development of PV is not clear. Here, we report that three immunoreactive segments of the ectodomain of Dsg3 specifically induced proliferation of T cells from PV patients. We found that T lymphocytes from 13 out of 14 patients responded to at least one of three Dsg3 peptides. T cells from controls and other patient groups did not respond to these Dsg3 peptides. The major T cell population stimulated by these Dsg3 peptides was CD4 positive. Dsg3-specific T cell lines and clones were developed and were shown to express a CD4 positive memory T cell phenotype. Upon stimulation, these cell lines and clones secreted a Th2-like cytokine profile. The Dsg3 responses of these T cells were restricted to HLA-DR, and not -DQ and -DP, of the major histocompatibility complex. This information will help to elucidate the cellular immune abnormalities leading to production of pathogenic IgG autoantibodies in patients with PV.
How Many People Can the Earth Support? (1998)

Estimates of the maximum number of people the earth can support have been developed and put forth routinely in environmental debates in UN reports and in papers by scholars or academic politicians trained in ecology economics sociology geography soil science or agronomy and other disciplines. However professional demographers tend to focus upon the composition and growth of populations restricting their predictions to the near term and framing them in conditional terms. How many people the earth can support depends upon nature as well as humankinds social economic cultural and political choices. There is not and will not be one single number of people the earth an support. Earths ultimate human carrying capacity hinges upon future constraints and possibilities which cannot yet be known since they remain in the future. The world still has room to accommodate additional population. However any major population growth is pointless. The population density needed for mankind to obtain all of the advantages of cooperation and social intercourse has in most populous countries already been attained.
2-Aminopyrimidine andp-phenylenediacetic acid (1:1) co-crystal (1999)

In the title co-crystal, each 2-aminopyrimidine molecule, C 4 H 5 N 3 , participates in two eight-membered hydrogen-bonded rings with carboxylic acid groups from two different phenylenediacetic acid molecules, C 10 H 10 O 4 . This results in infinite hydrogen-bonded chains. In the supramolecular structure, the chains are held together by weak C-H...O contacts.
Fluoride Ion-Promoted Reaction of Polyfluoro-1-propenyl p-Toluenesulfonate with Amines. Highly Efficient and General Access to (Z)-α-Fluoro-β-amino Acrylaldehydes (1994)

Abstract 2,3,3-Trifluoro-1-propenyl p-toluenesulfonate, readily available by dehydrofluorination of 2,2,3,3-tetrafluoropropyl p-toluenesulfonate, reacted smoothly with various primary or secondary amines in the presence of triethylamine and a catalytic amount of fluoride ion at ambient temperature for 3 h or at 70 °C for 1–2 h to afford the corresponding (Z)-α-fluoro-β-(alkylamino- or -dialkylamino)acrylaldehydes in good to excellent yields, together with the formation of p-toluenesulfonyl fluoride.
High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing (2013)

A major limitation of high-throughput DNA sequencing is the high rate of erroneous base calls produced. For instance, Illumina sequencing machines produce errors at a rate of ~0.1-1 × 10(-2) per base sequenced. These technologies typically produce billions of base calls per experiment, translating to millions of errors. We have developed a unique library preparation strategy, "circle sequencing," which allows for robust downstream computational correction of these errors. In this strategy, DNA templates are circularized, copied multiple times in tandem with a rolling circle polymerase, and then sequenced on any high-throughput sequencing machine. Each read produced is computationally processed to obtain a consensus sequence of all linked copies of the original molecule. Physically linking the copies ensures that each copy is independently derived from the original molecule and allows for efficient formation of consensus sequences. The circle-sequencing protocol precedes standard library preparations and is therefore suitable for a broad range of sequencing applications. We tested our method using the Illumina MiSeq platform and obtained errors in our processed sequencing reads at a rate as low as 7.6 × 10(-6) per base sequenced, dramatically improving the error rate of Illumina sequencing and putting error on par with low-throughput, but highly accurate, Sanger sequencing. Circle sequencing also had substantially higher efficiency and lower cost than existing barcode-based schemes for correcting sequencing errors.
Tietz Textbook of Clinical Chemistry, Third Edition. Carl A. Burtis and Edward R. Ashwood, eds. Philadelphia, PA: WB Saunders, 1998, 1917 pp., $195.00. ISBN 0-7216-5610-2. (1999)

One can identify a good textbook in medicine by its being authoritative, useful, comprehensive, facile, inclusive, and well-organized. One needs to ask whether one would use the book every day, as the first place to refer and the last. The third edition of the Tietz Textbook of Clinical Chemistry fits this bill.

The editors of the Tietz Textbook have made several changes from the previous edition. They have added chapters covering Laboratory Management, Cytokines, Cardiac Function, and Organ Transplantation; split Amino Acids and Proteins into two chapters; and combined the chapters on Osmometry, Electrolytes, Blood Gases and pH, and Acid-Base Balance and Acid-Base Disorders into one chapter. In addition, the chapter on Endocrinology has been split into six chapters, now entitled General Endocrine Function, Pituitary Function, Thyroid Function, Function of the Adrenal Cortex-Mix, Catecholamines …
Mastitis of Periparturient Holstein Cattle: A Phenotypic and Genetic Study (1995)

Environmental and genetic factors affecting somatic cell scores, clinical mastitis, and IMI by minor and major pathogens were studied on 137 periparturient Holstein cows selected for milk production. Environmental effects were obtained by generalized least squares and logistic regression. Genetic parameters were from BLUP and threshold animal models. Lactation number affected the number of quarters with clinical mastitis and the number of quarters infected with minor pathogens. The DIM affected somatic cell score and number of quarters infected with major pathogens. Heritabilities for all mastitis indicators averaged 10%, but differences occurred among the indicators. Correlations between breeding values of the number of quarters infected with minor pathogens and the number infected with major pathogens were antagonistic and statistically significant.
Performance enhancement of strained-Si MOSFETs fabricated on a chemical-mechanical-polished SiGe substrate (2002)

Chemical-mechanical-polishing (CMP) was used to smooth the surface of a SiGe substrate, on which strained-Si n- and p-MOSFETs were fabricated. By applying CMP after growing the SiGe buffer layer, the surface roughness was considerably reduced, namely, to 0.4 nm (rms). A strained-Si layer was then successfully grown on the CMP-treated SiGe substrate. The fabricated strained-Si MOSFETs showed good turn-off characteristics, (i.e., equivalent to those of Si control devices). Moreover, capacitance-voltage (CV) measurements revealed that the quality of the gate oxide of the strained-Si devices was the same as that of the Si control devices. Flat-band and threshold voltages of the strained-Si devices were different from those of the Si control devices mainly due to band discontinuity. Electron and hole mobilities of strained-Si MOSFETs under a vertical field up to 1.5 MV/cm increased by 120% and 42%, respectively, compared to the universal mobility. Furthermore, current drive of the n- and p-MOSFETs (L/sub eff//spl ges/0.3 /spl mu/m) was increased roughly by 70% and 50%, respectively. These improvements in characteristics indicate that CMP of the SiGe substrate is a critical technique for developing high-performance strained-Si CMOS.
Particle Display: A Quantitative Screening Method for Generating High‐Affinity Aptamers (2014)

We report an aptamer discovery technology that reproducibly yields higher affinity aptamers in fewer rounds compared to conventional selection. Our method (termed particle display) transforms libraries of solution-phase aptamers into "aptamer particles", each displaying many copies of a single sequence on its surface. We then use fluorescence-activated cell sorting (FACS) to individually measure the relative affinities of >10(8) aptamer particles and sort them in a high-throughput manner. Through mathematical analysis, we identified experimental parameters that enable optimal screening, and demonstrate enrichment performance that exceeds the theoretical maximum achievable with conventional selection by many orders of magnitude. We used particle display to obtain high-affinity DNA aptamers for four different protein targets in three rounds, including proteins for which previous DNA aptamer selection efforts have been unsuccessful. We believe particle display offers an extraordinarily efficient mechanism for generating high-quality aptamers in a rapid and economic manner, towards accelerated exploration of the human proteome.
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation (2011)

The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel FXR agonists, a structure-based pharmacophore model collection was developed and theoretically evaluated against virtual databases including the ChEMBL database. The most suitable models were used to screen the National Cancer Institute (NCI) database. Biological evaluation of virtual hits led to the discovery of a novel FXR agonist with a piperazine scaffold (compound 19) that shows comparable activity as the endogenous FXR agonist chenodeoxycholic acid (CDCA, compound 2).
Target mediated disposition of T84.66, a monoclonal anti-CEA antibody (2010)

Carcinoembryonic antigen (CEA) is a glycosylated cell surface antigen known to be highly overexpressed in several adenocarcinomas, including colorectal cancer, while demonstrating limited expression in normal tissues. Prior work has shown that the plasma clearance of T84.66, a monoclonal anti-CEA antibody, is enhanced by several-fold in a CEA-expressing xenograft mouse model, suggesting the presence of a target mediated elimination pathway. The purpose of this study is to investigate the influence of tumor volume on the plasma clearance of T84.66, and test the hypothesis that the plasma pharmacokinetics of T84.66 may be used as a sensitive and selective test for the diagnosis of CEA-positive tumors. T84.66 plasma pharmacokinetics were studied following intravenous (i.v.) administration of a 1 mg/kg dose in animals without tumor and mice bearing low (20-75 mm(3)), medium (400-570 mm(3)), and high volume (800-1,200 mm(3)) LS174T xenografts. Based on comparison of the disposition of T84.66 in non-tumor bearing mice and mice bearing low-volume tumors, it was predicted that a single plasma concentration of T84.66, obtained seven days after dosing, would provide a sensitive and selective means of determining the presence of tumor in mice. A blinded follow-up study was conducted using athymic mice with or without intraperitoneal LS174T xenografts. 1 mg/kg of (125)I-T84.66 was administered i.v., and plasma samples were collected on day 7. Comparison of the observed concentration of (125)I-T84.66 to the pre-determined threshold value (7.63 nM) enabled identification of tumor bearing mice with a sensitivity of 93.3% and specificity of 100%.
Pulmonary Hazards of Smoking Marijuana as Compared with Tobacco (1988)

To compare the pulmonary hazards of smoking marijuana and tobacco, we quantified the relative burden to the lung of insoluble particulates (tar) and carbon monoxide from the smoke of similar quantities of marijuana and tobacco. The 15 subjects, all men, had smoked both marijuana and tobacco habitually for at least five years. We measured each subject's blood carboxyhemoglobin level before and after smoking and the amount of tar inhaled and deposited in the respiratory tract from the smoke of single filter-tipped tobacco cigarettes (900 to 1200 mg) and marijuana cigarettes (741 to 985 mg) containing 0.004 percent or 1.24 percent delta 9-tetrahydrocanabinol. As compared with smoking tobacco, smoking marijuana was associated with a nearly fivefold greater increment in the blood carboxyhemoglobin level, an approximately threefold increase in the amount of tar inhaled, and retention in the respiratory tract of one third more inhaled tar (P less than 0.001). Significant differences were also noted in the dynamics of smoking marijuana and tobacco, among them an approximately two-thirds larger puff volume, a one-third greater depth of inhalation, and a fourfold longer breath-holding time with marijuana than with tobacco (P less than 0.01). Smoking dynamics and the delivery of tar during marijuana smoking were only slightly influenced by the percentage of tetrahydrocanabinol. We conclude that smoking marijuana, regardless of tetrahydrocannabinol content, results in a substantially greater respiratory burden of carbon monoxide and tar than smoking a similar quantity of tobacco.
Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy (2001)

An endoscopic photoacoustic probe is designed and tested for use in PDT treatment of esophageal cancer. The probe, measuring less than 2.5 mm in diameter, was designed to fit within the lumen of an endoscope that will be inserted into an esophagus after PDT. PDT treatment results in a blanched, necrotic layer of cancerous tissue over a healthy, deeper layer of perfused tissue. The photoacoustic probe was designed to use acoustic propagation time to determine the thickness of the blanched surface of the esophagus, which corresponds to treatment depth. A side-firing 600 micrometers fiber delivered 532 nm laser light to induce acoustic waves in the perfused layer of the esophagus beneath the blanched (treated) layer. A PVDF transducer detected the induced acoustic waves and transmitted the signal to an oscilloscope. The probe was tested on clear and turbid tissue phantom layers over an optically absorbing dye solution.
T‐cell tolerance and the multi‐functional role of IL‐2R signaling in T‐regulatory cells (2011)

Signaling through the interleukin-2 receptor (IL-2R) contributes to T-cell tolerance by controlling three important aspects of regulatory T-cell (Treg) biology. IL-2 is essential for thymic Treg development and regulates Treg homeostasis and suppressive function. Analogous to activated conventional T lymphocytes, IL-2R signaling also plays an important part in Treg cell growth, survival, and effector differentiation. However, Treg cells somewhat distinctively assimilate IL-2R signaling. In particular, Treg cells require essentially only IL-2-dependent receptor proximal signal transducer and activator of transcription 5 (Stat5) activation, as they contain inhibitory pathways to minimize IL-2R-dependent activation of the phosphatidyinositol 3-kinase/Akt pathway. Moreover, many IL-2R-dependent activities, including full induction of Foxp3 expression, in Treg cells require minimal and transient Stat5 activation. Thus, Treg cells are equipped to sense and then develop and function within biological niches containing minimal IL-2. These distinguishing features of IL-2R signaling provide a mechanistic underpinning for using IL-2 as an agent to selectively target Treg cells in immunotherapy to induce tolerance in autoimmune diseases and in allogeneic transplant recipients.