gebhart/patrepeval huggingface dataset:
Omid: Lock-free transactional support for distributed data stores (2014)

In this paper, we introduce Omid, a tool for lock-free transactional support in large data stores such as HBase. Omid uses a centralized scheme and implements snapshot isolation, a property that guarantees that all read operations of a transaction are performed on a consistent snapshot of the data. In a lock-based approach, the unreleased, distributed locks that are held by a failed or slow client block others. By using a centralized scheme for Omid, we are able to implement a lock-free commit algorithm, which does not suffer from this problem. Moreover, Omid lightly replicates a read-only copy of the transaction metadata into the clients where they can locally service a large part of queries on metadata. Thanks to this technique, Omid does not require modifying either the source code of the data store or the tables' schema, and the overhead on data servers is also negligible. The experimental results show that our implementation on a simple dual-core machine can service up to a thousand of client machines. While the added latency is limited to only 10 ms, Omid scales up to 124K write transactions per second. Since this capacity is multiple times larger than the maximum reported traffic in similar systems, we do not expect the centralized scheme of Omid to be a bottleneck even for current large data stores.
Activation peptide of carboxypeptidase B in serum and urine in acute pancreatitis (1998)

CAPAP could be a valuable tool in the diagnosis and early determination of severity in acute pancreatitis.
Bioceramics of Calcium Phosphate (1984)

CRC Press, Inc., Boca Raton, FL, 1983, ISBN 0–8493-6456–6, 146 pp., $49.00 (U.S.), S56.00 (outside U.S.)
Latest Developments in Gene Transfer Technology: Achievements, Perspectives, and Controversies over Therapeutic Applications (2000)

Over the last decade, more than 300 phase I and phase II gene-based clinical trials have been conducted worldwide for the treatment of cancer and monogenic disorders. Lately, these trials have been extended to the treatment of AIDS and, to a lesser extent, cardiovascular diseases. There are 27 currently active gene therapy protocols for the treatment of HIV-1 infection in the USA. Preclinical studies are currently in progress to evaluate the possibility of increasing the number of gene therapy clinical trials for cardiopathies, and of beginning new gene therapy programs for neurologic illnesses, autoimmuno diseases, allergies, regeneration of tissues, and to implement procedures of allogeneic tissues or cell transplantation. In addition, gene transfer technology has allowed for the development of innovative vaccine design, known as genetic immunization. This technique has already been applied in the AIDS vaccine programs in the USA. These programs aim to confer protective immunity against HIV-1 transmission to individuals who are at risk of infection. Research programs have also been considered to develop therapeutic vaccines for patients with AIDS and generate either preventive or therapeutic vaccines against malaria, tuberculosis, hepatitis A, B and C viruses, influenza virus, La Crosse virus, and Ebola virus. The potential therapeutic applications of gene transfer technology are enormous. However, the effectiveness of gene therapy programs is still questioned. Furthermore, there is growing concern over the matter of safety of gene delivery and controversy has arisen over the proposal to begin in utero gene therapy clinical trials for the treatment of inherited genetic disorders. From this standpoint, despite the latest significant achievements reported in vector design, it is not possible to predict to what extent gene therapeutic interventions will be effective in patients, and in what time frame.
Protein adsorption to poly(ethylene oxide) surfaces (1991)

Surfaces containing poly(ethylene oxide) (PEO) are interesting biomaterials because they exhibit low degrees of protein adsorption and cell adhesion. In this study different molecular weight PEO molecules were covalently attached to poly(ethylene terephthalate) (PET) films using cyanuric chloride chemistry. Prior to the PEO immobilization, amino groups were introduced onto the PET films by exposing them to an allylamine plasma glow discharge. The amino groups on the PET film were next activated with cyanuric chloride and then reacted with bis-amino PEO. The samples were characterized by scanning electron microscopy, water contact angle measurements, gravimetric analysis, and electron spectroscopy for chemical analysis (ESCA). The adsorption of 125I-labeled baboon fibrinogen and bovine serum albumin was studied from buffer solutions. Gravimetric analysis indicated that the films grafted with the low-molecular-weight PEO contained many more PEO molecules than the surfaces grafted with higher-molecular-weight PEO. The high-molecular-weight PEO surfaces, however, exhibited greater wettability (lower water contact angles) and less protein adsorption than the low-molecular-weight PEO surfaces. Adsorption of albumin and fibrinogen to the PEO surfaces decreased with increasing PEO molecular weight up to 3500. A further increase in molecular weight resulted in only slight decreases in protein adsorption. Protein adsorption studies as a function of buffer ionic strength suggest that there may be an ionic interaction between the protein and the allylamine surface. The trends in protein adsorption together with the water contact angle results and the gravimetric analysis suggest that a kind of "cooperative" water structuring around the larger PEO molecules may create an "excluded volume" of the hydrated polymer coils. This may be an important factor contributing to the observed low protein adsorption behavior.
Growth of Eubacterium limosum with Carbon Monoxide as the Energy Source (1982)

Eubacterium limosum grew with CO as the sole source of energy and formed acetate and CO 2 as the major products. The generation time on CO was 7 h. Uninhibited growth occurred in cultures containing 50% CO or less, but growth occurred at all concentrations tested (i.e., up to 75% CO). The pH optimum for growth was 7.0 to 7.2, whereas growth was poor at a pH below 6.7. CO 2 stimulated growth on CO. CO was preferentially utilized when both CO and H 2 were present.
A Copper(I) Bis-phenanthroline Complex Buried in Fullerene-Functionalized Dendritic Black Boxes (1999)

Virtual inaccessibility to external contact was revealed by electrochemical investigations for a bis(1,10-phenanthroline)copper(I) core embedded in dendrimers with up to 16 peripheral fullerene units (shown schematically). With increasing numbers of fullerene units, less and less light is available to the core, and the small quantity of light energy that reaches the central Cu(I) complex is returned to the external fullerenes by energy transfer-the central core is buried in a dendritic black box.
Vision system for fast 3-D model reconstruction (2004)

A desktop vision system is presented for complete 3-D model reconstruction. It is fast (3-D reconstruction in under 20 min), low cost (uses a commercially available digital camera and a rotation stage), and accurate (about 1 part in 500 in the working range). Partial 3-D shapes and texture information are acquired from multiple viewing directions using rotational stereo and shape-from-focus (SFF). The resulting range images are registered to a common coordinate system, and a surface representation is created for each range image. The resulting surfaces are integrated using an algorithm named region of construction. Unlike previous approaches, the region of construction algorithm directly exploits the structure of the raw range images. The algorithm determines regions in the range images corresponding to nonredundant surfaces that can be stitched along the boundaries to construct a complete 3-D surface model. The algorithm is computationally efficient and less sensitive to registration error. It also has the ability to construct complete 3-D models of complex objects with holes. A textured 3-D model is obtained by mapping texture information onto the complete surface model representing the 3-D shape. Experimental results for several real objects are presented.
Entity recognition for sensor network motes (extended abstract) (2005)

Abstract: Message authenticity (knowing “who sent this message”) is an important security issue for sensor networks, and often difficult to solve. Sometimes, it may be sufficient and more efficient to solve the simpler entitiy recognition problem, instead: “is the message from the same entity that sent the previous messages?”. This paper describes entity recognition for sensor network motes. A protocol presented at SAC 2003 [9] is shown to be insecure, and a new and provably secure protocol is proposed. 1
T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma (2009)

Asthma can be divided into at least two distinct molecular phenotypes defined by degree of Th2 inflammation. Th2 cytokines are likely to be a relevant therapeutic target in only a subset of patients with asthma. Furthermore, current models do not adequately explain non-Th2-driven asthma, which represents a significant proportion of patients and responds poorly to current therapies.
[VIR576 inhibits antigen-specific T cell activation by binding to the transmembrane domain of T cell receptor]. (2009)

VIR576 is effective in suppressing the antigen-specific T cell activation via TCR and can interact with TCR-TMD. VIR576 may serve as a potent microbicide candidate to block sexual transmission of HIV due to of its inhibitory effect on both HIV entry and antigen-specific T cell activation.
Automated optical measurements of human torso surface movements during breathing (1986)

An automated light-sectioning system has been developed for continuously measuring the movements of the torso surface during breathing. The body is illuminated with planes of light of a known geometry, and the body is visualized with television cameras. The perceived angles at which the television scan detected the planes projected onto the body are encoded digitally and stored continuously on magnetic tape. Subsequently the geometry of the torso can be reconstructed at 80-ms intervals enabling the detailed pattern of movements and volume displacement over the torso surface to be determined. Displacements of 0.5 mm over the torso surface can be resolved, and respired volume can be measured to within 10% over the range of the vital capacity.
CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth (2012)

Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways to elicit T- and B-cell responses. CD27 signaling is regulated by the expression of its ligand CD70 on subsets of dendritic cells and lymphocytes. Here, we analyzed the role of the CD27-CD70 interaction in the immunologic control of solid tumors in Cd27-deficient mice. In tumor-bearing wild-type mice, the CD27-CD70 interaction increased the frequency of regulatory T cells (Tregs), reduced tumor-specific T-cell responses, increased angiogenesis, and promoted tumor growth. CD27 signaling reduced apoptosis of Tregs in vivo and induced CD4(+) effector T cells (Teffs) to produce interleukin-2, a key survival factor for Tregs. Consequently, the frequency of Tregs and growth of solid tumors were reduced in Cd27-deficient mice or in wild-type mice treated with monoclonal antibody to block CD27 signaling. Our findings, therefore, provide a novel mechanism by which the adaptive immune system enhances tumor growth and may offer an attractive strategy to treat solid tumors.
Localization error analysis for stereo X-ray image guidance with probability method (2001)

The mean value and standard deviation of localization error for the stereo imaging systems are derived based on probability theory. Compared with the maximum error analysis method used in our previous study, the new approach yields more informative and precise results as the guidance for X-ray imaging system design and protocol optimization. The prototype for our current study is a CCD based monoplane digital stereo X-ray imaging system. The imaging model consists of two X-ray sources and one detector plane. With perspective geometry, the least-square solution is derived to reconstruct 3-dimensional object points, such as a biopsy needle tip, from a pair of 2-dimensional digital radiographs. Under the conditions of our specific prototype, the measurement errors of interested points in the radiographs are modeled as random variables with Gaussian distribution. Such variables account for finite image system noise and positioning errors. Then, the 3D localization error, in terms of mean value and standard deviation, is formulated using measurement error, feature point location, and separation between the two X-ray sources and distance from source to detector. Both theoretical analysis and numerical simulation are performed. The mean value and standard deviation of the localization error are first evaluated using numerical simulation under practical imaging conditions. Then, the error estimates are given in simply analytic forms. Simulation and theoretical results are in excellent agreement. The results show that our prototype X-ray stereological imaging system is accurate and reliable to locate feature points in 3D for medical intervention. Imaging protocols can be effectively optimized through the 3D localization error analysis using the approximate formulas proposed in this study.
Base-Catalyzed Reaction of Acetylene and Vinylacetylenes with Carbonyl Compounds in Liquid Ammonia under Pressure (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBase-Catalyzed Reaction of Acetylene and Vinylacetylenes with Carbonyl Compounds in Liquid Ammonia under PressureR. J. Tedeschi, A. W. Casey, G. S. Clark Jr., R. W. Huckel, L. M. Kindley, and J. P. RussellCite this: J. Org. Chem. 1963, 28, 7, 1740–1743Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July 1963https://pubs.acs.org/doi/10.1021/jo01042a002https://doi.org/10.1021/jo01042a002research-articleACS PublicationsRequest reuse permissionsArticle Views473Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long‐Term Prospective Study of Methotrexate in the Treatment of Rheumatoid Arthritis (1992)

The effectiveness of MTX in the treatment of RA continues to be demonstrated in this prospective study, after 84 months of treatment.
Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma (2011)

Although immunotherapy with Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) can treat EBV-associated Hodgkin and non-Hodgkin lymphoma (HL/NHL), more than 50% of such tumors are EBV negative. We now describe an approach that allows us to consistently generate, in a single line, CTLs that recognize a wide spectrum of nonviral tumor-associated antigens (TAAs) expressed by human HL/NHL, including Survivin, MAGE-A4, Synovial sarcoma X (SSX2), preferentially expressed antigen in melanoma (PRAME) and NY-ESO-1. We could generate these CTLs from nine of nine healthy donors and five of eight lymphoma patients, irrespective of human leukocyte antigen (HLA) type. We reactivated TAA-directed T cells ex vivo, by stimulation with dendritic cells (DCs) pulsed with overlapping peptide libraries spanning the chosen antigens in the presence of an optimized Th1-polarizing, prosurvival/proliferative and Treg inhibitory cytokine combination. The resultant lines of CD4(+) and CD8(+), polycytokine-producing T cells are directed against a multiplicity of epitopes expressed on the selected TAAs, with cytolytic activity against autologous tumor cells. Infusion of such multispecific monocultures may extend the benefits of CTL therapy to treatment even of EBV negative HL and NHL.
Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system (2008)

The precursor form of the nerve growth factor (proNGF), forms a heterotrimeric complex with the receptors p75 and sortilin; this complex has been implicated in neuron cell death. However, it is not known whether proNGF and the receptors p75 and sortilin contribute to age- and disease-related neurodegeneration. Here we show that proNGF induces cell death in subpopulations of basal forebrain and peripheral sympathetic neurons of old, but not of young, adult rodents. In contrast, proNGF appears to induce neurite outgrowth rather than cell death of young adult sympathetic neurons. We have examined the neurotoxic role of proNGF in old age, and find that proNGF protein is elevated during ageing in the projection areas of some populations of vulnerable central and peripheral neurons; caloric restriction, which has known neuroprotective effects, partially prevents these increases. Sortilin was found to play a significant part in the observed patterns of age-related proNGF-mediated neurotoxicity. In particular, survival of aged neurons was rescued by neurotensin, an alternative sortilin ligand that blocks the sortilin-mediated effects of proNGF. Furthermore, sortilin immunoreactivity increases markedly in ageing rodent basal forebrain and sympathetic neurons; in contrast, p75 levels are either unchanged or reduced. From these data we propose that selective age-related neuronal atrophy and neurodegeneration may be mediated by increased sortilin expression in neurons, together with elevated levels of proNGF expression in some targets.
Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. (1993)

The blood group i/I antigens were the first identified alloantigens that display a dramatic change during human development. The i and I antigens are determined by linear and branched poly-N-acetyllactosaminoglycans, respectively. In human erythrocytes during embryonic development, the fetal (i) antigen is replaced by the adult (I) antigen as a result of the appearance of a beta-1,6-N-acetylglucosaminyltransferase, the I-branching enzyme. Here, we report the cDNA cloning and expression of this branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans, thus introducing the I antigen in transfected cells. The cDNA sequence predicts a protein with type II membrane topology as has been found for all other mammalian glycosyltransferases cloned to date. The Chinese hamster ovary cells that stably express the isolated cDNA acquire I-branched structures as evidenced by the structural analysis of glycopeptides from these cells. Comparison of the amino acid sequence with those of other glycosyltransferases revealed that this I-branching enzyme and another beta-1,6-N-acetylglucosaminyltransferase that forms a branch in O-glycans are strongly homologous in the center of their putative catalytic domains. Moreover, the genes encoding these two beta-1,6-N-acetylglucosaminyltransferases were found to be located at the same locus on chromosome 9, band q21. These results indicate that the I-branching enzyme represents a member of a beta-1,6-N-acetylglucosaminyltransferase gene family of which expression is controlled by developmental programs.
Parallel determination of absolute distances to multiple targets by time-of-flight measurement using femtosecond light pulses (2015)

Distances to multiple targets are measured simultaneously using a single femtosecond pulse laser split through a diffractive optical element. Pulse arrival from each target is detected by means of balanced cross-correlation of second harmonics generated using a PPKTP crystal. Time-of-flight of each returning pulse is counted by dual-comb interferometry with 0.01 ps timing resolution at a 2 kHz update rate. This multi-target ranging capability is demonstrated by performing multi-degree of freedom (m-DOF) sensing of a rigid-body motion simulating a satellite operating in orbit. This method is applicable to diverse terrestrial and space applications requiring concurrent multiple distance measurements with high precision.
Photodynamic therapy in the treatment of microbial infections: Basic principles and perspective applications (2006)

PDT appears to represent an efficacious alternative modality for the treatment of localized microbial infections through the in situ application of the photosensitizer followed by irradiation of the photosensitizer-loaded infected area. Proposed clinical fields of interest of antimicrobial PDT include the treatment of chronic ulcers, infected burns, acne vulgaris, and a variety of oral infections.
Illuminating the molecular basis for some antipsychotic drug-induced metabolic burden (2007)

The atypical antipsychotic drugs (AAPDs), especially olanzapine (OLZ), quetiapine, and risperidone, are the most widely used treatments for schizophrenia (SCH) and other psychotic illnesses, having, in the last decade, displaced the typical antipsychotic drugs (TAPDs), such as haloperidol, chlorpromazine, and others of that class. However, as a group, the AAPDs are currently receiving an unprecedented level of scrutiny in the scientific literature and public forums because some recent well publicized studies have not confirmed some key aspects of their reputed advantages for efficacy, cost-effectiveness, and tolerability (1, 2). The propensity of OLZ, once the most widely used AAPD, to cause weight gain, glucose dysregulation, lipid increases, especially triglycerides, and diabetes mellitus (DM), including diabetic ketoacidosis, has been linked to the very high rate of ischemic cardiovascular disease and a 20- to 25-year-shorter life span of people with SCH in the United States. Clozapine (CLZ), which is much less widely used than OLZ because of its risk for agranulocytosis, produces weight gain similar to that of OLZ. In this issue of PNAS, Kim et al. (3) show for the first time that these two AAPDs stimulate hypothalamic AMP-protein kinase (AMPK) through histamine1 receptor (H1R) antagonism, a likely molecular basis for their metabolic liability. They demonstrate that activation of hypothalamic AMPK was abolished in H1R knockout mice. Other AAPDs that produce less weight gain than CLZ and OLZ were less effective at activating AMPK in intact animals.