gebhart/patrepeval huggingface dataset:
Exogenous carbohydrate oxidation during ultraendurance exercise (2005)

The purposes of this study were: 1) to obtain a measure of exogenous carbohydrate (CHO(Exo)) oxidation and plasma glucose kinetics during 5 h of exercise; and 2) to compare CHO(Exo) following the ingestion of a glucose solution (Glu) or a glucose + fructose solution (2:1 ratio, Glu+Fru) during ultraendurance exercise. Eight well-trained subjects exercised three times for 5 h at 58% maximum O2 consumption while ingesting either Glu or Glu+Fru (both delivering 1.5 g/min CHO) or water. The CHO used had a naturally high 13C enrichment, and five subjects received a primed continuous intravenous [6,6-2H2]glucose infusion. CHO(Exo) rates following the ingestion of Glu leveled off after 120 min and peaked at 1.24 +/- 0.04 g/min. The ingestion of Glu+Fru resulted in a significantly higher peak rate of CHO(Exo) (1.40 +/- 0.08 g/min), a faster rate of increase in CHO(Exo), and an increase in the percentage of CHO(Exo) oxidized (65-77%). However, the rate of appearance and disappearance of Glu continued to increase during exercise, with no differences between trials. These data suggest an important role for gluconeogenesis during the later stages of exercise. Following the ingestion of Glu+Fru, cadence (rpm) was maintained, and the perception of stomach fullness was reduced relative to Glu. The ingestion of Glu+Fru increases CHO(Exo) compared with the ingestion of Glu alone, potentially through the oxidation of CHO(Exo) in the liver or through the conversion to, and oxidation of, lactate.
Fetal learning: a prospective randomized controlled study (2002)

Prenatal music exposure alters the fetal behavioral state and is carried forward to the newborn period. This suggests that a simple form of fetal programming or learning has occurred.
Statistical Methods for Survival Data Analysis. (1993)

Praise for the Third Edition. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject. Statistics in Medical ResearchUpdated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences.Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes:Marginal and random effect models for analyzing correlated censored or uncensored dataMultiple types of two-sample and K-sample comparison analysisUpdated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time modelsExpanded coverage of the Cox proportional hazards modelExercises at the end of each chapter to deepen knowledge of the presented materialStatistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.
Selective loss of human leukocyte class I allospecificities and staining of melanoma cells by monoclonal antibodies recognizing monomorphic determinants of class I human leukocyte antigens. (1993)

Immunoperoxidase staining of frozen sections from surgically removed melanoma lesions showed that anti-human leukocyte antigen (HLA)-A2, A28 monoclonal antibody (mAb) stained keratinocytes, but did not stain melanoma cells in 21% of the 14 primary and 44% of the 9 metastatic lesions tested. The loss of HLA-A2 and/or A28 allospecificities did not affect the staining patterns with mAb recognizing monomorphic determinants of HLA Class I antigens, in terms of percentage of stained melanoma cells and intensity of staining. This finding is not likely to reflect the sensitivity of the immunoperoxidase technique, since cytofluorographic analysis detected no significant difference in the staining pattern by mAb to monomorphic determinants of HLA Class I antigens between a melanoma cell line and an autologous transfectant that had acquired HLA-A2 antigens following gene transfer. The results of the present study imply that the frequency of abnormalities in HLA Class I antigen expression by melanoma cells is higher than that described in the literature, since selective losses of HLA Class I allospecificities are not detected by staining of melanoma cells with mAb to monomorphic determinants of HLA Class I antigens. The latter reagents have been used in most of the published studies to characterize the expression of HLA Class I antigens in melanoma lesions. Furthermore, the present results provide a mechanism for the unexpected resistance to cytotoxic T-cell-mediated lysis and the unexpected poor clinical course of the disease in some patients despite a high expression of HLA Class I antigens as measured by staining of melanoma cells with mAb to monomorphic determinants.
Bridged-ring nitrogen compounds. Part 5. Synthesis of 2,6-methano-3-benzazonine ring-systems (1981)

Syntheses of cis- and trans-4-benzyl- and 4-(3-methoxybenzyl)-2-methoxycarbonyl-1-methylpiperidines are described; amino-acids and amino-alcohols obtained from these compounds failed to cyclise. cis-2-Benzyl-4-ethoxycarbonyl-1-methylpiperidine has been made and its amino-acid hydrochloride cyclised in polyphosphoric acid at 160 °C to give 2,4,5,6,7-hexahydro-3-methyl-2,6-methano-1H-3-benzazonin-7-one which was converted into several derivatives. 4-Benzyl-4-ethoxycarbonyl-1-methylpiperidine, obtained by two routes, was hydrolysed and cyclised to give N-methylspiro[indane-2,4′-piperidine]-1-one which was also converted into several derivatives.
Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats (1997)

Melatonin administered at the beginning of cerebral reperfusion protected CA1 neurons against 10, 20 and 30 min of transient forebrain ischemia. Intraperitoneal injections of saline or melatonin (10 mg/kg) were given after 0, 2 and 6 h, or 1, 2 and 6 h of cerebral reperfusion, or 30 min prior to ischemia. One week later, quantitative histological analysis demonstrated that CA1 neuronal density was significantly increased in the melatonin groups that were treated at 0, 2, 6 h compared to the saline-treated controls. Ischemic protection of CA1 was lost in the animals in which the melatonin treatment was delayed by 1 h, or given 30 min prior to the ischemia.
Ricin: Mechanism of Action, Detection, and Intoxication (1995)

The many uses of ricin for basic research and clinical studies have made it an intensively studied molecule. Although the exact mechanism by which the toxin kills animals is unknown, ricin kills cells by entering the cytosol and inhibiting protein synthesis. In all areas of clinical use, forensic medicine, and basic scientific inquiry, the capability to detect the toxin is of primary importance. Recent efforts to produce a vaccine originate from a perception that this widely available toxic plant protein could be a poor man's weapon of mass destruction.
Biosynthesis of Surfactant Protein D (1996)

Surfactant protein D (SP-D) is preferentially secreted as dodecamers consisting of four collagenous trimers cross-linked by disulfide bonds. In these studies, we examined the biosynthesis of wild-type rat SP-D (RrSP-D) and selected mutants by stably transfected CHO-K1 cells to determine the roles of a conserved N-linked oligosaccharide, the collagen helix, and interchain disulfide bonds in SP-D assembly and secretion. The major intracellular form of RrSP-D accumulated in the RER as complexes containing up to four trimeric subunits. Disulfide cross-link formation and RrSP-D secretion were selectively inhibited by 2,2'-dipyridyl, an inhibitor of prolyl and lysyl hydroxylase, and by 2 mM dithiothreitol, but unaffected by tunicamycin or elimination of the consensus sequence for glycosylation at Asn70. Although mutants with serine substituted for Cys15 and Cys20 (RrSP-Dser15/20) are secreted as trimeric subunits, proteins with single cysteine substitutions were retained in the cell. Surprisingly, the secretion of RrSP-Dser15/20 was unaffected by 2,2'-dipyridyl. These studies strongly suggest that the most important and rate-limiting step for the secretion of SP-D involves the association of cross-linked trimeric subunits to form dodecamers stabilized by specific inter-subunit disulfide cross-links. Interference with collagen helix formation prevents secretion by interfering with efficient disulfide cross-linking of the NH2-terminal domain.
Use of Plasma Biomarkers at Exacerbation of Chronic Obstructive Pulmonary Disease (2006)

Plasma CRP concentration, in the presence of a major exacerbation symptom, is useful in the confirmation of COPD exacerbation. Systemic biomarkers were not helpful in predicting exacerbation severity. The acute-phase response at exacerbation was most strongly related to indices of monocyte function.
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis (2003)

Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.
A no-reference perceptual blur metric (2003)

We present a no-reference blur metric for images and video. The blur metric is based on the analysis of the spread of the edges in an image. Its perceptual significance is validated through subjective experiments. The novel metric is near real-time, has low computational complexity and is shown to perform well over a range of image content. Potential applications include optimization of source coding, network resource management and autofocus of an image capturing device.
The Wnt/Wg Signal Transducer β-Catenin Controls Fibronectin Expression (1999)

beta-Catenin stabilizes the cadherin cell adhesion complex but, as a component of the Wnt/Wg signaling pathway, also controls gene expression by forming a heterodimer with a transcription factor of the LEF-TCF family. We demonstrate that the substrate adhesion molecule fibronectin is a direct target of Wnt/Wg signaling. Nuclear depletion of beta-catenin following cadherin transfection in Xenopus fibroblasts resulted in downregulation of fibronectin expression which was restored by activating the Wnt/Wg signaling cascade via LiCl treatment or transfection of either Xwnt-8 or beta-catenin. We isolated the Xenopus fibronectin gene (FN) promoter and found four putative LEF-TCF binding sites. By comparing the activities of different fibronectin gene reporter constructs in fibroblasts and cadherin transfectants, the LEF-TCF site at position -368 was identified as a Wnt/Wg response element. LEF-1-related proteins were found in nuclei of the fibroblasts but were absent in a kidney epithelial cell line. Consistent with the lack of these transcription factors, the FN promoter was silent in the epithelial cells but was activated upon transfection of LEF-1. Wild-type Xenopus Tcf-3 (XTcf-3) was unable to activate FN promoter reporter constructs, while a mutant lacking the groucho binding region behaved like LEF-1. In contrast to XTcf-3, LEF-1 does not interact with groucho proteins, which turn TCFs into activators or repressors (J. Roose, M. Molenaar, J. Hurenkamp, J. Peterson, H. Brantjes, P. Moerer, M. van de Wetering, O. Destreé, and H. Clevers, Nature 395:608-612, 1998). Together these data provide evidence that expressing LEF-1 enables fibroblasts, in contrast to epithelial cells, to respond to the Wnt/Wg signal via beta-catenin in stimulating fibronectin gene transcription. Our findings further promote the idea that due to its dual function, beta-catenin regulates the balance between cell-cell and cell-substrate adhesion.
Substrate Properties of C′-Methylnucleoside and C′-Methyl-2′-deoxynucleoside 5′-Triphosphates in RNA and DNA Synthesis Reactions Catalysed by RNA and DNA Polymerases (1991)

Abstract C'-Methyl derivatives of NTP and dNTP were Prepared and their substrate properties were investigated in RNA and DNA synthesis reactions.
Synthesis and Molecular and Electronic Structures of Reduced Bis(imino)pyridine Cobalt Dinitrogen Complexes: Ligand versus Metal Reduction (2010)

Sodium amalgam reduction of the aryl-substituted bis(imino)pyridine cobalt dihalide complexes ((Ar)PDI)CoCl(2) and ((iPr)BPDI)CoCl(2) ((Ar)PDI = 2,6-(2,6-R(2)-C(6)H(3)N=CMe)(2)C(5)H(3)N (R = (i)Pr, Et, Me); (iPr)BPDI = 2,6-(2,6-(i)Pr(2)-C(6)H(3)N=CPh)(2)C(5)H(3)N) in the presence of an N(2) atmosphere furnished the corresponding neutral cobalt dinitrogen complexes ((Ar)PDI)CoN(2) and ((iPr)BPDI)CoN(2). Magnetic measurements on these compounds establish doublet ground states. Two examples, ((iPr)PDI)CoN(2) and ((iPr)BPDI)CoN(2), were characterized by X-ray diffraction and exhibit metrical parameters consistent with one-electron chelate reduction and a Co(I) oxidation state. Accordingly, the toluene solution EPR spectrum of ((iPr)PDI)CoN(2) at 23 degrees C exhibits an isotropic signal with a g value of 2.003 and hyperfine coupling constant of 8 x 10(-4) cm(-1) to the I = 7/2 (59)Co center, suggesting a principally bis(imino)pyridine-based SOMO. Additional one-electron reduction of ((iPr)PDI)CoN(2) was accomplished by treatment with Na[C(10)H(8)] in THF and yielded the cobalt dinitrogen anion [((iPr)PDI)CoN(2)](-). DFT calculations on the series of cationic, neutral, and anionic bis(imino)pyridine cobalt dinitrogen compounds establish Co(I) centers in each case and a chelate-centered reduction in each of the sequential one-electron reduction steps. Frequency calculations successfully reproduce the experimentally determined N[triple bond]N infrared stretching frequencies and validate the computational methods. The electronic structures of the reduced cobalt dinitrogen complexes are evaluated in the broader context of bis(imino)pyridine base metal chemistry and the influence of the metal d electron configuration on the preference for closed-shell versus triplet diradical dianions.
Electrical and optical characteristics of vacuum-sealed polysilicon microlamps (1992)

A silicon-filament vacuum-sealed incandescent light source has been fabricated using IC technology and subsurface micromachining. The incandescent source consists of a heavily doped p/sup +/ polysilicon filament coated with silicon nitride and enclosed in a vacuum-sealed ( approximately=80-mT) cavity in the silicon-chip surface. The filament is formed beneath the surface and later released using sacrificial etching to obtain a microstructure that is protected from the external environment. The filament is electrically heated to reach incandescence at a temperature near 1400 K. The power required to achieve this temperature (for a filament 510*5*1 mu m) is 5 mW. The emitted optical power is 250 mu W, and the peak in the spectrum distribution is near 2.5 mu m. The radiation approximately follows Lambert's cosine law. The subsurface micromachining technique used to produce the evacuated cavity has applications in other micromechanical devices.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions (2011)

In summary, our data demonstrate that the SphK1/S1P(3) signaling axis is upregulated when astrocytes are activated by LPS. This signaling pathway appears to play a role in the establishment and maintenance of astrocyte activation. Upregulation of the pathway in MS may be detrimental, e.g. through enhancing astrogliosis, or beneficial through increased remyelination via CXCL1.
Destruction of Human Lymphoid Tissue-Culture Cell Lines by Human Peripheral Lymphocytes in 51Cr-Release Cellular Cytotoxicity Assays2 (1974)

Journal Article Destruction of Human Lymphoid Tissue-Culture Cell Lines by Human Peripheral Lymphocytes in 51Cr-Release Cellular Cytotoxicity Assays Get access Eugene B. Rosenberg, Eugene B. Rosenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar James L. McCoy, James L. McCoy Search for other works by this author on: Oxford Academic PubMed Google Scholar Stanley S. Green, Stanley S. Green Search for other works by this author on: Oxford Academic PubMed Google Scholar Francis C. Donnelly, Francis C. Donnelly Search for other works by this author on: Oxford Academic PubMed Google Scholar David F. Siwarski, David F. Siwarski Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul H. Levine, Paul H. Levine Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald B. Herberman Ronald B. Herberman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 2, February 1974, Pages 345–352, https://doi.org/10.1093/jnci/52.2.345 Published: 01 February 1974 Article history Received: 08 June 1973 Accepted: 12 October 1973 Published: 01 February 1974
PCA-SIFT: a more distinctive representation for local image descriptors (2004)

Stable local feature detection and representation is a fundamental component of many image registration and object recognition algorithms. Mikolajczyk and Schmid (June 2003) recently evaluated a variety of approaches and identified the SIFT [D. G. Lowe, 1999] algorithm as being the most resistant to common image deformations. This paper examines (and improves upon) the local image descriptor used by SIFT. Like SIFT, our descriptors encode the salient aspects of the image gradient in the feature point's neighborhood; however, instead of using SIFT's smoothed weighted histograms, we apply principal components analysis (PCA) to the normalized gradient patch. Our experiments demonstrate that the PCA-based local descriptors are more distinctive, more robust to image deformations, and more compact than the standard SIFT representation. We also present results showing that using these descriptors in an image retrieval application results in increased accuracy and faster matching.
Diagnostic Validity of the Dementia Questionnaire for Alzheimer Disease (1998)

Compared with the results of the antemortem clinical examinations, the DQ was sensitive to the presence of dementia, detected most cases of mild dementia, and discriminated dementia from other neurologic disorders causing functional impairment. Compared with the neuropathological diagnoses, the ability of the DQ to differentiate Alzheimer disease from other dementing disorders indicates that it may be useful as a research tool.
Hybrid Quantum Processors: Molecular Ensembles as Quantum Memory for Solid State Circuits (2006)

We investigate a hybrid quantum circuit where ensembles of cold polar molecules serve as long-lived quantum memories and optical interfaces for solid state quantum processors. The quantum memory realized by collective spin states (ensemble qubit) is coupled to a high-Q stripline cavity via microwave Raman processes. We show that, for convenient trap-surface distances of a few microm, strong coupling between the cavity and ensemble qubit can be achieved. We discuss basic quantum information protocols, including a swap from the cavity photon bus to the molecular quantum memory, and a deterministic two qubit gate. Finally, we investigate coherence properties of molecular ensemble quantum bits.
Plasmid-mediated, carbapenem-hydrolysing beta-lactamase, KPC-2, in Klebsiella pneumoniae isolates (2003)

Four isolates of Klebsiella pneumoniae obtained from patients at a Maryland medical centre exhibited reduced susceptibility to carbapenems and were found to produce the novel, class A, plasmid-mediated, carbapenem-hydrolysing enzyme, KPC-2. This enzyme has 99% identity with the plasmid-mediated, carbapenem-hydrolysing enzyme KPC-1, reported previously in a North Carolina K. pneumoniae isolate. The KPC-2-producing isolates were either susceptible or intermediate to imipenem and meropenem, unlike the KPC-1-producing isolate, which was resistant to these agents. Detection of KPC-2 may be a problem for clinical laboratories because in this study it was associated with positive extended-spectrum beta-lactamase (ESBL) confirmation tests (clavulanate-potentiated activities of ceftriaxone, ceftazidime, cefepime and aztreonam). Therefore, a failure to recognize the significance of reduced carbapenem susceptibility in the isolates that remained susceptible to imipenem or meropenem could have resulted in the isolates being incorrectly identified as ESBL producers.
Training for Collaboration and Cognitive Alignment (2005)

This study extends the theory of Recognition Primed Decision-Making by applying it to groups. Furthermore, we explore implicit and explicit training. An experiment was conducted in which teams made resource allocation decisions while physically dispersed and supported with a shared virtual work surface (What You See Is What I See - WYSIWIS). The task required teams to recognize patterns and collaborate to allocate their resources appropriately. The experiment explores the use of a cognitively aligned tool designed to minimize the cognitive effort required to for teams to recognize and share recognized patterns. Dependent measures included outcome quality, resource allocation time, and resource allocation ordering. All teams received significant financial rewards in direct proportion to their outcome quality. Teams supported with the âchunkâ pattern-sharing tool had highest outcome quality.
Shape from focus (1994)

The shape from focus method presented here uses different focus levels to obtain a sequence of object images. The sum-modified-Laplacian (SML) operator is developed to provide local measures of the quality of image focus. The operator is applied to the image sequence to determine a set of focus measures at each image point. A depth estimation algorithm interpolates a small number of focus measure values to obtain accurate depth estimates. A fully automated shape from focus system has been implemented using an optical microscope and tested on a variety of industrial samples. Experimental results are presented that demonstrate the accuracy and robustness of the proposed method. These results suggest shape from focus to be an effective approach for a variety of challenging visual inspection tasks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Compact low-loss adiabatic bends in silicon shallow-etched waveguides (2016)

We report an adiabatic bend based on silicon shallow-etched waveguide using a sine-circle-sine design. The loss per 180° turn is 0.05 dB for 5 μm bend and 0.008 dB 10 μm bend for TE polarization, which are significantly lower than that of a circular bend.