gebhart/patrepeval huggingface dataset:
Radio resource management in wireless communication : beamforming, transmission power control, and rate allocation (2007)

Effective sharing of the radio spectrum in current and future multi-user radio communication systems is important for the maximisation of communication capacity. Efficient sharing requires obtaining the target ratio between signal and interference powers defined by the requested services for every user with minimum use of resources. In this thesis, three radio resource management techniques – transmission power control, adaptive beamforming, and transmission rate management – are considered separately and jointly in attacking the problem of radio channel sharing. Transmission power control balances the signal-to-interference ratios of the connections, adaptive beamforming performs spatial filtering of signal in antenna arrays, and transmission rate management controls communication speeds of all connections in the system.\n\nThis thesis proposes an algorithm for block proportional–integral transmission power control. It combines the ideas of updating the transmission powers of different connections in blocks of chosen connections and using a multiple-input, multiple-output proportional–integral controller in the transmission power balancing. The algorithm is compared to the single-input, single-output proportional–integral controller scenario and is seen to offer faster convergence to the optimal transmission powers. Adaptive beamforming weight vector prediction algorithms are introduced for decreasing the negative impact of the beamformer delay on the system performance. The prediction algorithms are based on autoregressive-moving average models, where parameters are updated using recursive least squares technique. This thesis takes practical approaches to joint beamforming and power control. Separate solutions are proposed for the receiving and transmission beamforming systems. Both solutions are based on making SINR estimates according to the covariance matrices of desired signals, which can be applied in transmission power control of corresponding connections.\n\nFor transmission rate management, the feasibility of applying the power control point of view is taken. Solutions are based on the channel measurements and allocation of rates on the basis of the interference. The approach results in rate allocations that are fairer between users than those obtained via maximisation of communications capacity.\n\nIn addition to cellular radio systems, this thesis addresses radio resource management of wireless sensor networks. Antenna array beamforming solutions are considered in receivers and transmitters of star-topology sensor networks.
Restoration of Meibomian Gland Functionality With Novel Thermodynamic Treatment Device-A Case Report (2010)

A new and previously unpublished thermodynamic treatment device, which for the first time applies heat directly to both inner eyelid surfaces with a precision-controlled resistive heater while pulsating pressure is simultaneously applied to the outer eyelids using an inflatable air bladder, was used to restore meibomian gland functionality for a subject with severe evaporative dry eye. The subject, a 39-year-old white woman of light complexion with severe symptoms and corroborating objective signs of dry eye, had been unsuccessfully treated for 3 years by 7 practitioners. Using a new standardized meibomian gland expression device, a diagnosis of nonobvious meibomian gland dysfunction, where none of the approximately 24 meibomian glands of the right lower eyelid and 1 meibomian gland of the left lower eyelid were functional, was made. The patient underwent a single 12-minute treatment per eye with the treatment device. The treatment restored the functionality of 8 glands in each eye, doubled the fluorescein break-up time (FBUT) from 5 to 10 seconds, and decreased the symptom scores by approximately 80% for the entire follow-up period of 3 months.
Total Synthesis of Balanol (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of BalanolK. C. Nicolaou, Mark E. Bunnage, and Kazunori KoideCite this: J. Am. Chem. Soc. 1994, 116, 18, 8402–8403Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00097a072https://doi.org/10.1021/ja00097a072research-articleACS PublicationsRequest reuse permissionsArticle Views2989Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The Use of Near-Infrared Spectrometry for the Diagnosis of Lower-Extremity Compartment Syndrome (2011)

While intracompartmental pressure monitoring is a widely used diagnostic tool to measure intracompartmental pressures in the setting of compartment syndrome, its invasive nature has prompted the development of noninvasive techniques, such as near-infrared spectrometry. We prospectively assessed the association between tissue oxygen saturation measured by near-infrared spectrometry and compartment pressure measured by intracompartmental pressure monitoring in a cohort of patients with compartment syndrome of the lower extremity. We hypothesized that tissue oxygen saturation measured by near-infrared spectrometry would negatively correlate with intracompartmental pressures. Tissue oxygen saturation was determined for all 4 compartments of the lower extremity in 7 patients using near-infrared spectrometry. All patients subsequently underwent lower-extremity fasciotomies. Mechanism of injury, compartment pressures, blood pressure, near-infrared spectrometry measurement of tissue oxygen saturation, and characteristics of the muscle at the time of fasciotomy were recorded. The strength of the correlations between tissue oxygen saturation and absolute and relative compartment pressures was estimated based on mixed linear (growth) models with repeated observations nested within patients. Our analyses demonstrated no significant relationship between tissue oxygen saturation measured by near-infrared spectrometry and the absolute or relative compartment pressures. This suggests that compartment tissue oxygen saturation measurements by near-infrared spectrometry do not correlate with the diagnosis of compartment syndrome, and that near-infrared spectrometry would not serve as a reliable diagnostic tool.
Amniotic fluid stem cells provide considerable advantages in epidermal regeneration: B7H4 creates a moderate inflammation microenvironment to promote wound repair (2015)

The current treatments for severe skin injury all involve skin grafting. However, there is a worldwide shortage of donor skin tissue. In this study, we examined the advantages of using human amniotic fluid stem (hAFS) cells in skin wound healing. In vitro, hAFS cells differentiate into keratinocytes (termed hAFS-K). Like keratinocytes, hAFS-K cells express the markers K5, K14, K10 and involucrin; display typical cellular structure, including a tonofibril-rich cytoplasm; and construct a completely pluristratified epithelium in 3D culture. In vivo, in a mouse excisional wound model, GFP-positive hAFS cells participate in wound repair. Co-localization of GFP/K14 and GFP/K10 in the repaired epidermis demonstrated that hAFS cells can differentiate into keratinocytes. Real-time PCR results confirmed that hAFS cells can initiate and promote early-stage repair of skin damage. During wound repair, hAFS cells did not directly secrete repair-related factors, such as bFGF, VEGF, CXCL12, TGF-β1 and KGF, and provided a moderate inflammation reaction with lower expression of IL-1β, IL-6, TNF-α, Cox2 and Mac3. In hAFS cells, the negative co-stimulatory molecule B7H4 regulates low immunogenicity, which can provide a modest inflammatory reaction microenvironment for wound repair. Furthermore, with their uniquely high proliferation rate, hAFS cells offer a promising alternative for epidermal regeneration.
Vascular biology of coronary bypass grafts (1991)

Clinical studies on the natural history of coronary bypass grafts strongly suggest that biologic properties of the vessels used importantly affect their function and patency. The endothelium is a source of substances regulating vascular tone, platelet function, and vascular growth; it produces nitric acid from L-arginine, which is a potent vasodilator and inhibitor of platelet function and has antiproliferative properties. Nitric oxide and prostacyclin, which have a similar profile of action, are released in greater amounts in arterial than venous coronary bypass vessels. Vascular smooth muscle cells are primary regulators of local blood flow and contribute to proliferative responses. The right gastroepiploic artery exhibits more pronounced contractions than the mammary artery but has a similar sensitivity to vasoconstrictors. Proliferative responses in coronary bypass vessels appear to be induced by changes in transmural pressure (particularly in veins), endothelial damage, and in turn, local release of platelet-derived growth factors, low-density lipoproteins, and intrinsic characteristics of the blood vessels. Thus, biologic properties of the endothelium and vascular smooth muscle significantly contribute to the function and patency of coronary bypass grafts. While the mammary artery has near-ideal characteristics, the right gastroepiploic artery exhibits marked contractile responses and the saphenous vein has unsatisfactory antithrombotic properties and more pronounced proliferative responses.
PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES (1992)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response. (1996)

The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for cancer vaccine development. In murine models of Id vaccination, formulation of syngeneic Id with carrier proteins or adjuvants induces an anti-idiotypic antibody response. However, inducing a potent cell-mediated response to this weak antigen instead would be highly desirable. In the 38C13 lymphoma model, we observed that low doses of free granulocyte/macrophage colony-stimulating factor (GM-CSF) 10,000 units i.p. or locally s.c. daily for 4 days significantly enhanced protective antitumor immunity induced by s.c. Id-keyhole limpet hemocyanin (KLH) immunization. This effect was critically dependent upon effector CD4+ and CD8+ T cells and was not associated with any increased anti-idiotypic antibody production. Lymphocytes from spleens and draining lymph nodes of mice primed with Id-KLH plus GM-CSF, but not with Id-KLH alone, demonstrated significant proliferation to Id in vitro without any biased production of interferon gamma or interleukin 4 protein or mRNA. As a further demonstration of potency, 50% of mice immunized with Id-KLH plus GM-CSF on the same day as challenge with a large s.c. tumor inoculum remained tumor-free at day 80, compared with 17% for Id-KLH alone, when immunization was combined with cyclophosphamide. Taken together, these results demonstrate that GM-CSF can significantly enhance the immunogenicity of a defined self-antigen and that this effect is mediated exclusively by activating the T-cell arm of the immune response.
Ultra‐large effective‐area, higher‐order mode fibers: a new strategy for high‐power lasers (2008)

Abstract This paper describes the physics and properties of a novel optical fiber that would be attractive for building high‐power fiber lasers and amplifiers. Instead of propagating light in the fundamental, Gaussian‐shaped mode, we describe a fiber in which the signal is forced to travel in a single, desired higher order mode (HOM). This provides for several advantages over the conventional approach, ranging from significantly higher ability to scale mode areas (and hence laser powers) to managing dispersion for ultra‐short pulses – a capability that is practically nonexistent in conventional fibers. Particularly interesting is the fact that this approach challenges conventional wisdom, and demonstrates that for applications requiring meter‐length fibers (as in high‐power lasers), signal stability actually increases with mode order. Using this approach, we demonstrate mode areas exceeding 3200 μm 2 , and propagate signals with negligible mode distortions over up to 50‐meter lengths. We describe several pulse propagation experiments in which we test the nonlinear response of this fiber platform, ranging from managing dispersive effects in femtosecond pulse systems, to reducing Brillouin scattering impairments in systems operating with the nanosecond pulses.
Hematopoietic stem cell mobilization (2008)

ecruitment of hematopoietic stem/progenitor cells (HSC) from the bone marrow into peripheral blood following treatment with chemotherapy and/or cytokines is termed mobilization. The release of HSC from the bone marrow is a physiological phenomenon for the protection of HSC from toxic injury, as circulating cells can re-engraft bone marrow, or to maintain a fixed number of HSC in the bone marrow (homeostatic mechanism). ] These advantages include shorter duration of granulocytopenia, enhanced immune reconstitution, reduced morbidity and mortality, shorter hospital stay and saving of financial resources. However, several factors affect HSC mobilization: age, type and dose of cytokines used and, in the autologous setting, the patient's diagnosis, mobilizing chemotherapy regimen, number and type of previous chemotherapy cycles or radiation, and interval from last chemotherapy cycle. Indeed, depending on these characteristics, a significant proportion of patients receiving standard mobilization for the purpose of autologous transplantation or allogeneic donors still fail to mobilize bone marrow cells into the periphery. Although an extensive description of factors influencing HSC mobilization 9 and current clinical trials involving transplantation of peripheral blood stem cells is beyond the scope of this perspective article, we report here some of the bio-molecular mechanisms leading to the release of HSC from the bone marrow to help the understanding of novel strategies under development to make stem cell collection more effective.
Characterisation of a novel repetitive DNA sequence from Mycobacterium bovis (1992)

We report characterisation of three copies of a novel repeat sequence isolated from a Mycobacterium bovis genomic library. The repeat occurs within open reading frames, potentially encoding a conserved tandem array of a pentapeptide sequence with the consensus X-Gly-Asn-X-Gly. The tandem array is present up to five times in M. bovis and it is proposed that they may occur in a family of genes expressing functionally related proteins. We postulate that these proteins may play a role in binding of M. bovis to host cell receptors.
Moving from logical sharing of guest OS to physical sharing of deduplication on virtual machine (2010)

Current OSes include many logical sharing techniques (shared library, symbolic link, etc.) on memory and storage. Unfortunately they cause security and management problems which come from the dynamic management of logical sharing; e.g., search path replacement attack, GOT (Global Offset Table) overwrite attack, Dependency Hell, etc. This paper proposes that self-contained binaries eliminate the problems caused by logical sharing. The memory and storage overheads caused by self-contained binaries are mitigated by physical sharing (memory and disk deduplication). The effect of deduplication was investigated on the KVM virtual machine with KSM
p-n junction-based wafer flow process for stencil mask fabrication (1998)

The development of stencil masks is considered to be critical to the success of the new ion projection lithography technology. We present here a p-n junction wafer flow process where all fabrication steps are realized on a bulk Si wafer except the final trench etching through the 2–4-μm-thick Si membrane. Stencil masks were produced in a conventional complementary metal-oxide-semiconductor 150 mm wafer line, using an e-beam direct writing tool for patterning. The resist patterns were transferred by standard reactive ion etching (RIE) into a stress-controlled SiON hard mask layer. Subsequent to depositing an Al metal layer for contact to the n-doped wafer surface, the membrane was realized by a wet chemical etch which implemented well established reverse biased p-n junction etch stop techniques. Then, openings through the Si membrane were etched by RIE or inductively coupled plasma etching. Finally, the remaining hard mask layer was removed in BHF. The realized Si membrane diameter was 120 mm with a stencil pattern field of 60 mm×60 mm. Results from LMS-IPRO placement measurements are in agreement with the simulation of the stencil mask fabrication process using finite element methods.
Toward the Development of a Synthetic Group A Streptococcal Vaccine of High Purity and Broad Protective Coverage (2004)

Using native chemical ligation, we synthesized a group A streptococcal (GAS) vaccine that contained three different GAS M protein peptide epitopes in a chemically well-characterized construct in high purity. Two of the peptide epitopes represented variable amino terminal serotype determinants, and the third represented a carboxyl terminal conserved region determinant of the GAS M protein. We also synthesized a lipid core peptide (LCP) construct containing the same three peptides. Upon immunization of mice, the non-LCP construct only elicited antibody responses to all three epitopes with the use of adjuvant. The LCP construct, however, elicited excellent antibody responses to all three epitopes without the need for any additional adjuvant or carrier. We have synthesized the LCP synthetic vaccine system with good reproducibility.
Preservation of surface‐dependent properties of viral antigens following immobilization on particulate ceramic delivery vehicles (1995)

B-cell stimulation for the purpose of evoking an effective neutralizing humoral immune response is a surface phenomenon that is exquisitely specific to antigen conformation. Consequently, successful delivery of antigen, such as would be desired in a vaccine, entails preservation of an antigen's apparent native surface (conformational) properties. Prior to testing the actual vaccinating efficacy of delivered antigens, the surface properties could be assessed through a variety of in vitro and in vivo assays in which the measurement standard would be the properties of the antigens in their native state (whole virus). Using surface modified nanocrystalline carbon and calcium-phosphate ceramic particulates (carbon ceramics and brushite), we evaluated the surface activity of immobilized non-nuclear material extracted from HIV-1. Physical characterization showed that the particles with immobilized antigen ("HIV decoys") measured 50 nm in diameter (HIV = 50-100 nm) and exhibited the same zeta potentials as whole (live) HIV. In vitro testing showed that the HIV decoys were recognized by both conformationally nonspecific and specific monoclonal antibodies, were recognized by human IgG from HIV antibody-positive patients, and could promote surface agglomeration among malignant T-cells similar to live HIV. Last, in vivo testing in three vaccinated animal species showed that the HIV decoys elicited humoral and cellular immune responses similar to that evoked by whole (live) HIV.
Minimum Origin Requirements for Linear Duplex AAV DNA Replication in Vitro (1995)

We have investigated the minimal requirements for a functional origin of DNA replication in an in vitro assay which requires the adeno-associated virus (AAV) Rep 68/78 protein. When a linear duplex template was used, initiation of one round of DNA replication was achieved when nucleotides 1-56 of the AAV inverted terminal repeat (in the flop orientation) were present at the terminus of the template. A terminal resolution site was not required. Deletion of an additional 11 nucleotides from the terminal repeat blocked the reaction.
Real-time user-guided image colorization with learned deep priors (2017)

We propose a deep learning approach for user-guided image colorization. The system directly maps a grayscale image, along with sparse, local user "hints" to an output colorization with a Convolutional Neural Network (CNN). Rather than using hand-defined rules, the network propagates user edits by fusing low-level cues along with high-level semantic information, learned from large-scale data. We train on a million images, with simulated user inputs. To guide the user towards efficient input selection, the system recommends likely colors based on the input image and current user inputs. The colorization is performed in a single feed-forward pass, enabling real-time use. Even with randomly simulated user inputs, we show that the proposed system helps novice users quickly create realistic colorizations, and offers large improvements in colorization quality with just a minute of use. In addition, we demonstrate that the framework can incorporate other user "hints" to the desired colorization, showing an application to color histogram transfer.
Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions (2002)

The presence of babA2(+) H pylori strains alone or in combination with cagA(+) and vacA s1 was associated with the presence of preneoplastic gastric lesions.