gebhart/patrepeval huggingface dataset:
Derivatives of 5-Nitro-furan-2-carboxylic Acid Carbamoylmethyl Ester Inhibit RNase H Activity Associated with HIV-1 Reverse Transcriptase (2009)

The RNase H activity associated with human immunodeficiency virus type 1 (HIV-1) is an attractive target for an antiretroviral drug development. We screened 20000 small-molecular-weight compounds for RNase H inhibitors and identified a novel RNase H-inhibiting structure characterized by a 5-nitro-furan-2-carboxylic acid carbamoylmethyl ester (NACME) moiety. Two NACME derivatives, 5-nitro-furan-2-carboxylic acid adamantan-1-carbamoylmethyl ester (compound 1) and 5-nitro-furan-2-carboxylic acid [[4-(4-bromo-phenyl)-thiazol-2-yl]-(tetrahydro-furan-2-ylmethyl)-carbamoyl]-methyl ester (compound 2), effectively blocked HIV-1 and MLV RT-associated RNase H activities with IC(50)s of 3-30 microM but had little effect on bacterial RNase H activity in vitro. Additionally, 20-25 microM compound 2 effectively inhibited HIV-1 replication. An in silico docking simulation indicated that the conserved His539 residue, and two metal ions in the RNase H catalytic center are involved in RNase H inhibition by NACME derivatives. Taken together, these data suggest that NACME derivatives may be potent lead compounds for development of a novel class of antiretroviral drugs.
A new efficient method of generating processor load data and meta data base in CMS-MX system (2002)

A distributed real-time data base management system has been used in CDMA mobile system-mobile exchange (CMS-MX) system, where the data base schema and initial data base are constructed from exchange data input form (EDIF) files and data input language (DIL) files. In this paper, we propose a new efficient method of generating meta data base (MDB) and processor load data (PLD) from EDIF files and DIL files. The proposed method provides strong verification capabilities to guarantee the consistency of data base schema. It also reduces the data base construction time by simplifying its process.
Tecto-RNA: One-Dimensional Self-Assembly through Tertiary Interactions (2000)

The modularity of natural RNA is the basis for the design of tecto-RNA, modular RNA units capable of directed self-assembly. One such modular association through specific RNA loop–receptor tertiary interactions, which leads to one-dimensional oligomer arrays, is demonstrated (see picture).
Activation of the Aryl Hydrocarbon Receptor Leads to Resistance to EGFR TKIs in Non–Small Cell Lung Cancer by Activating Src-mediated Bypass Signaling (2017)

<b>Purpose:</b> The aryl hydrocarbon receptor (AhR) has been generally recognized as a ligand-activated transcriptional factor that responds to xenobiotic chemicals. Recent studies have suggested that the expression of AhR varies widely across different cancer types and cancer cell lines, but its significance in cancer treatment has yet to be clarified.<b>Experimental Design:</b> AhR expression in non-small cell lung cancer (NSCLC) was determined by Western blotting and IHC staining. <i>In vitro</i> and <i>in vivo</i> functional experiments were performed to determine the effect of AhR on sensitivity to targeted therapeutics. A panel of biochemical assays was used to elucidate the underlying mechanisms.<b>Results:</b> A high AhR protein level indicated an unfavorable prognosis for lung adenocarcinoma. Inhibition of AhR signaling sensitized EGFR tyrosine kinase inhibitors (TKIs) in NSCLC cells that express high level of endogenous AhR protein. Notably, activation of AhR by pharmacologic and molecular approaches rendered EGFR-mutant cells resistant to TKIs by restoring PI3K/Akt and MEK/Erk signaling through activation of Src. In addition, we found that AhR acts as a protein adaptor to mediate Jak2-Src interaction, which does not require the canonical transcriptional activity of AhR.<b>Conclusions:</b> Our results reveal a transcription-independent function of AhR and indicate that AhR may act as a protein adaptor that recruits kinases bypassing EGFR and drives resistance to TKIs. Accordingly, targeting Src would be a strategy to overcome resistance to EGFR TKIs in AhR-activated NSCLC. <i>Clin Cancer Res; 24(5); 1227-39. ©2017 AACR</i>.
Ethnic, Gender, and Contact Differences in Intimacy Attitudes Toward Wheelchair Users (2012)

Student attitudes toward having a relationship with a wheelchair user were explored. Participants initially selected one of six opposite gender head shots and subsequently viewed their selection’s whole body photograph in a wheelchair along with reading a short biography. Primarily undergraduate Hispanic and Caucasian students ( N = 810) were surveyed regarding their interest in potentially being friends, dating, or marrying a wheelchair user, with 66% indicating they would have no problem dating or marrying a wheelchair user. Chi-square tests of pairwise association, logistical regression, and test of proportional odds revealed significant differences, p = .001, between ethnicity, gender, type of relationship, and having had a prior disability relationship. Personal traits of intelligence, humor, kindness, and physical appearance were rated most highly. Those unwilling to date or marry their selection perceived the partner would require too much caregiving, social interaction awkwardness, inability to sexually perform, and the partner being sick often. Counselors can benefit from informing clients about intimacy misconceptions by role-playing and providing clients with insights regarding societal beliefs.
Non-equilibrium Statistical Mechanics and Turbulence (2008)

Methods of non-equilibrium statistical mechanics play an increasingly important role in modern turbulence research, yet the range of relevant tools and methods is so wide and developing so fast that until now there has not been a single book covering the subject. As an introduction to modern methods of statistical mechanics in turbulence, this volume rectifies that situation. The book comprises three harmonised lecture courses by world class experts in statistical physics and turbulence: John Cardy introduces Field Theory and Non-Equilibrium Statistical Mechanics; Gregory Falkovich discusses Turbulence Theory as part of Statistical Physics; and Krzysztof Gawedzki examines Soluble Models of Turbulent Transport. To encourage readers to deepen their understanding of the theoretical material, each chapter contains exercises with solutions. Essential reading for students and researchers in the field of theoretical turbulence, this volume will also interest any scientist or engineer who applies knowledge of turbulence and non-equilibrium physics to their work.
Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis. (1985)

Monoclonal antibody MB3.6 (IgG3) recognizes disialoganglioside GD3, which represents a major surface marker on most human melanoma cells. We demonstrate that this antibody effectively lyses four human melanoma cell lines expressing significant levels of GD3 on their surface by either of two mechanisms: antibody-dependent cellular cytotoxicity (ADCC) or complement-mediated cytotoxicity. However, a melanoma cell line that expresses minimal levels of GD3 on 13% of the cells shows insignificant lysis by MB3.6 by either of these two mechanisms, suggesting that a threshold level of antigen expression may be required for effective in vitro cytolysis. In addition, monoclonal antibody (MAb) MB3.6 effectively inhibits establishment and growth of human melanoma tumors in the nude mouse when injected 24 hr after subcutaneous inoculation of tumor cells. Furthermore, MB3.6 produces specific regression of established melanoma tumors when injected 7 days after the subcutaneous inoculation of tumor cells. In contrast, tumor growth in animals injected with the melanoma cell line expressing minimal levels of GD3 was not affected by MAb MB3.6. These data indicate that once appropriate levels of the GD3 ganglioside are expressed on human melanoma cells, MAb MB3.6 can mediate tumor cell killing in vitro and in vivo and, thus, may prove useful for effective immunotherapy of human malignant melanoma.
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION (1999)

We describe the formation, maturation, elimination, maintenance, and regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses. The NMJ forms in a series of steps that involve the exchange of signals among its three cellular components--nerve terminal, muscle fiber, and Schwann cell. Although essentially any motor axon can form NMJs with any muscle fiber, an additional set of cues biases synapse formation in favor of appropriate partners. The NMJ is functional at birth but undergoes numerous alterations postnatally. One step in maturation is the elimination of excess inputs, a competitive process in which the muscle is an intermediary. Once elimination is complete, the NMJ is maintained stably in a dynamic equilibrium that can be perturbed to initiate remodeling. NMJs regenerate following damage to nerve or muscle, but this process differs in fundamental ways from embryonic synaptogenesis. Finally, we consider the extent to which the NMJ is a suitable model for development of neuron-neuron synapses.
Suicide and Bipolar Disorder (2019)

Suicide, which is both a stereotypic yet highly individualized act, is a common endpoint for many patients with severe psychiatric illness. The mood disorders (depression and bipolar manic-depression) are by far the most common psychiatric conditions associated with suicide. At least 25% to 50% of patients with bipolar disorder also attempt suicide at least once. With the exception of lithium--which is the most demonstrably effective treatment against suicide-remarkably little is known about specific contributions of mood-altering treatments to minimizing mortality rates in persons with major mood disorders in general and bipolar depression in particular. Suicide is usually a manifestation of severe psychiatric distress that is often associated with a diagnosable and treatable form of depression or other mental illness. In a clinical setting, an assessment of suicidal risk must precede any attempt to treat psychiatric illness.
Atlas-based automatic segmentation of head and neck organs at risk and nodal target volumes: a clinical validation (2013)

The updated Brainlab atlas-based automatic segmentation tool for head and neck Cancer patients is timesaving but still necessitates review and corrections by an expert.
The use of context for correcting garbled English text (1964)

The paper describes two different methods for using context to correct garbled English text. The first makes use of a dictionary of English words containing their probability of occurrence. The second uses letter digram frequencies to roughly approximate English word probabilities. Probabilities of various letter substitutions are obtained from a confusion matrix of the simulated character recognizer whose operation produced the garbling. This information is combined using a maximum likelihood scheme to obtain word recognition or, if only digram information is available, the recognition of word approximations.
Cancer Statistics, 2005 (2005)

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,372,910 new cancer cases and 570,280 deaths are expected in the United States in 2005. When deaths are aggregated by age, cancer has surpassed heart disease as the leading cause of death for persons younger than 85 since 1999. When adjusted to delayed reporting, cancer incidence rates stabilized in men from 1995 through 2001 but continued to increase by 0.3% per year from 1987 through 2001 in women. The death rate from all cancers combined has decreased by 1.5% per year since 1993 among men and by 0.8% per year since 1992 among women. The mortality rate has also continued to decrease from the three most common cancer sites in men (lung and bronchus, colon and rectum, and prostate) and from breast and colorectal cancers in women. Lung cancer mortality among women has leveled off after increasing for many decades. In analyses by race and ethnicity, African American men and women have 40% and 20% higher death rates from all cancers combined than White men and women, respectively. Cancer incidence and death rates are lower in other racial and ethnic groups than in Whites and African Americans for all sites combined and for the four major cancer sites. However, these groups generally have higher rates for stomach, liver, and cervical cancers than Whites. Furthermore, minority populations are more likely to be diagnosed with advanced stage disease than are Whites. Progress in reducing the burden of suffering and death from cancer can be accelerated by applying existing cancer control knowledge across all segments of the population.
In vivo1H‐[13C]‐NMR spectroscopy of cerebral metabolism (2003)

13C NMR spectroscopy in combination with the infusion of (13)C-labeled precursors is currently the only technique that is capable of quantitatively studying energy metabolism, neurotransmission and other metabolic pathways non-invasively in vivo. (1)H-[(13)C]-NMR spectroscopy is a high-sensitivity alternative to direct (13)C NMR spectroscopy. The development of improved NMR methods for water suppression, spatial localization, broadband decoupling, shimming and signal quantification, together with the availability of high magnetic field strengths, has made (1)H-[(13)C]-NMR spectroscopy the method of choice for the detection of metabolism at a high spatial and/or temporal resolution. (1)H-[(13)C]-NMR spectroscopy can now be used to discriminate glutamatergic (excitatory) and GABAergic (inhibitory) neuronal activity. The improved sensitivity allows the detection of metabolism in different tissues (e.g. gray and white matter) and potentially even in smaller structures, like cortical layers. Finally, (1)H-[(13)C]-NMR spectroscopy allows the detection of energy metabolism and neurotransmission during functional activation, thereby further strengthening our understanding of the neurochemical basis of brain function.
Wide-field multispectral super-resolution imaging using spin-dependent fluorescence in nanodiamonds (2013)

By modulating the fluorescence brightness of nitrogen-vacancy (NV) defect centers in nanodiamonds, we demonstrate a ‘deterministic emitter switch microscopy’ (DESM) technique that enables super-resolution imaging with localization down to 47 nm across a 4×4µm2 area.
Automated analysis of gene-microarray images (2003)

cDNA micro-arrays are a relatively new technology that allow the viewing of gene expression of many genes (or other DNA fragments) simultaneously. The output of a micro-array experiment is a pair of digital images, each of which show thousands of individual spots. This paper introduces a novel, operator independent, and reproducible algorithm for determining the relative intensities of these spots. This method permits high throughput analysis of micro-array images, which is very desirable given the volume of data collected. This algorithm for automated spot location makes use of the regular structure of the images to produce an initial approximation of spot location, which is then iteratively refined. The algorithm will be tested on micro-array images produced at the Canadian Centre for Human and Animal Health, as well as on publicly available micro-array images.
Rise in heat‐shock protein level confers tolerance to energy deprivation (1993)

Heat shock (44 degrees C for 10 min) or ATP depletion by an uncoupler (CCCP for 20 min) is shown to result in stimulation of hsp68/70 synthesis in Ehrlich tumor cells. After 3 h of recovery, the cells become thermotolerant. Surprisingly, repeated ATP depletion caused by CCCP or rotenone (a respiratory inhibitor) treatment, had a much lower effect on cell viability. Both induction of tolerance to energy deprivation and hsp68/70 synthesis were totally suppressed by cycloheximide, an inhibitor of cytosolic protein synthesis. In tolerant cells, rotenone still induced ATP depletion; however, protein aggregation (the rise in Triton-insoluble proteins) was inhibited in these cells. It is suggested that cellular chaperones (e.g. hsp70) are involved in the protection of ischemic cells from necrosis, preventing protein aggregation under ATP deficiency.
Induction of meningococcal group B polysaccharide-specific IgG antibodies in mice by using an N-propionylated B polysaccharide-tetanus toxoid conjugate vaccine. (1986)

Conjugation of the group B meningococcal polysaccharide to tetanus toxoid failed to substantially enhance its immunogenicity in mice. Therefore, additional chemical manipulation of the basic structure of the group B meningococcal polysaccharide was attempted, on the premise that a synthetically derived artificial antigen might be capable of modulating the immune response in mice to produce elevated levels of cross-reactive group B meningococcal polysaccharide-specific antibodies. To achieve this, the antigenicity of the modified polysaccharide to group B meningococcal polysaccharide-specific antibodies had to be preserved, and this criterion could only be satisfied in modifications in which the carboxylate and N-carbonyl groups of the sialic acid residues of polysaccharide remained intact. Therefore, the most successful modifications were accomplished by N-deacetylation of the group B meningococcal polysaccharide with strong base to yield a precursor that could then be N-acetylated or N-arylated with different substituents. For example, the introduction of N-propionyl groups, followed by conjugation of the resultant N-propionylated group B meningococcal polysaccharide to tetanus toxoid, yielded an antigen that when injected in mice induced in them high levels of cross-reactive group B meningococcal polysaccharide-specific IgG antibodies. The T cell dependency of this antigen was established when it was demonstrated that the levels of these B polysaccharide-specific antibodies could be significantly boosted by using both the N-propionylated- and native N-acetylated-group B meningococcal polysaccharide-tetanus toxoid conjugates.
Letters to the Editor (2008)

Ceylon Medical Journal (CMJ) is a peer-reviewed, open access journal published quarterly by the Sri Lanka Medical Association in the last week of March, June, September and December each year. The mission of the CMJ is to promote the science and art of medicine and betterment of public health. The Journal publishes original papers and commentaries which have relevance to medicine and allied sciences. The CMJ is committed to maintaining and conforming to the editorial and ethical standards recommended by the International Committee of Medical Journal Editors.
Redox‐ and pH‐Controlled Mechanized Nanoparticles (2009)

Abstract A new class of mechanized silica nanoparticles, which exploits the stability of the inclusion complexes formed between ferrocenedicarboxylic acid and both cucurbit[7]uril (CB7) and β‐cyclodextrin (β‐CD), are described. Mesoporous silica nanoparticles, capable of storing a payload of small molecules and releasing it following particular activation processes, have been designed and decorated with ferrocenecarboxylic acid stalks. The storage and release of the payload is controlled by the host–guest interaction between the ferrocene moiety (guest) and the ring moiety (CB7 or β‐CD). Ferrocene‐based Mechanized NanoParticles (FMNPs) were efficiently prepared, loaded with Rhodamine dye, and then tested under different activation procedures. The systems operated successfully under redox control (oxidation of ferrocenedicarboxylic acid) in the presence of β‐CD and under pH control (deprotonation of ferrocenedicarboxylic acid pH &gt; 4) in the presence of CB7.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
<title>Architecture of an optical jukebox image archive</title> (1990)

The Radiology Department at the Hospital of the University of Pennsylvania is currently expanding its prototype Picture Archiving and Communications System ( PACS ) into a fully functional clinical system. The fi rst phase of this expansion involves three major efforts: the upgrade of the 10-Mbit token-ring to an 80-Mbit backbone with associated subnets, the implementation of a large-scale image archive, and, an interface between the PACS and the Department's Radiology Information System. Upon completion of this phase, the PACS will serve the storage and display needs of four MRI scanners and four of the Hospital' s Intensive Care Units . To achieve these objectives the Department entered into a joint development agreement with Vortech Data Inc. to develop applications-software for an optical jukebox-based image archive. This paper describes the developmental effort with special reference to the Image Archival and Retrieval System ( IRS). The IARS has three major features: a robust ACR/NEMA style protocol for external communication, a hierarchical storage system that incorporates magnetic, optical and shelf storage systems, and, a storage capacity that can be incrementally expanded from 25 GigaBytes to 7 TeraBytes.
Interpenetrating Polymer Networks (1994)

Interpenetrating polymer networks (IPNs) are combinations of two or more network polymers, synthesized in juxtaposition. Several methods of synthesis, particularly sequential IPNs and simultaneous interpenetrating networks, are described. As with polymer blends, blocks, and grafts, phase separation takes place during polymerization, hut the rules are different. Applications to the plastics and rubber industry are described, along with historical aspects.
Taming the Blackbody with Infrared Metamaterials as Selective Thermal Emitters (2011)

In this Letter we demonstrate, for the first time, selective thermal emitters based on metamaterial perfect absorbers. We experimentally realize a narrow band midinfrared (MIR) thermal emitter. Multiple metamaterial sublattices further permit construction of a dual-band MIR emitter. By performing both emissivity and absorptivity measurements, we find that emissivity and absorptivity agree very well as predicted by Kirchhoff's law of thermal radiation. Our results directly demonstrate the great flexibility of metamaterials for tailoring blackbody emission.
Prolonged Activation of NF-κB Following Traumatic Brain Injury in Rats (1999)

Activation of transcription factor, nuclear factor kappa B (NF-kappaB), has been shown to play a key role in inflammatory response, neuronal survival and signaling. We investigated the regional and temporal distribution of activated NF-kappaB in rats at 1 h, 2 h, 24 h, 48 h, 1 week, 2 weeks, 1 month, 2 months, 6 months, and 1 year following brain injury in rats. Early after trauma (1-2 h), activated NF-kappaB was detected in axons, and subsequently found in the cytoplasm and nucleus of neurons by 24 h and lasting up to 1 week. In addition, by 24 h posttrauma, activated NF-kappaB was detected in microglia/macrophages and astrocytes in injured cortex. Surprisingly, this activation persisted for at least 1 year following injury in the cortex, primarily at the margins of progressively enlarging ventricle. Activated NF-kappaB was also detected in endothelial cells, as early as 1 h, and persisted for up to 1 year. These results suggest that a neuronal response to brain trauma includes the activation of NF-kappaB first in the axon with subsequent translocation to the nucleus. Furthermore, these results demonstrate that remarkably prolonged activation of NF-kappaB in glia is found in the same regions undergoing persistent atrophy, suggesting NF-kappaB activation may play a role in long-term inflammatory processes following brain trauma.