gebhart/patrepeval huggingface dataset:
An inhibitor of Janus kinase 3: 4-(4-hydroxyphenylamino)-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate (2000)

The crystal structure of the title compound, C(16)H(16)N(3)O(3)(+). Cl(-).CH(4)O (WHI-P131, an inhibitor of Janus kinase 3), contains four hydrogen bonds. There are two hydrogen bonds within the asymmetric unit, i.e. interactions between WHI-P131 OH and Cl(-), and between methanol and Cl(-). There is a third interaction between WHI-P131 NH and Cl(-) (related by a 2(1) screw) and a fourth between WHI-P131 NH and methanol (related by an n-glide). The hydrogen-bond pattern for these interactions can be described by the first-level hydrogen-bond graph-set notation D(1)(1)(2)D(1)(1)(2)D(1)(1)(2)D(1)(1)(2). The second-level graph-set notation (for combinations of two hydrogen bonds) was determined to be D(1)(2)(3)D(1)(2)(3)D(2)(2)(4)D(2)(2)(9)D(2)(2)(14)C(1)(2)(9).
Mast cell density and IL‐8 expression in nonlesional and lesional psoriatic skin (2001)

The results of this study suggest that increased levels of IL-8 in the keratinocytes of psoriatic plaques play a contributing role in the migration of mast cells to lesion sites.
Simple and covalent fabrication of a paper device and its application in sensitive chemiluminescence immunoassay (2012)

In this paper, chemiluminescence immunoassay (CLIA) was introduced into the recently proposed microfluidic paper-based analytical devices (μPADs) through covalent fabrication strategy for the first time. This novel paper-based CLIA, with high-throughput, rapid, stable and reusable CL response to trace amounts of analyte in real biological samples, combines the simplicity and low-cost of the μPADs with the high sensitivity and selectivity of CLIA. Periodate oxidation, which can form covalent bonds between polysaccharides and proteins, was used for activation of μPADs to covalently immobilize antibodies on μPADs in this work for the first time. Thus, the paper-based sandwich CLIA and regeneration of it can be easily realized for further development of this technique in sensitive, specific and low-cost applications. The application test of this paper-based CLIA was successfully performed, as a model, through the determination of biomarkers in human serum on paper microzone plate. The paper-based CLIA will be very useful when the level of an analyte in real biological sample is important for point-of-care testing, public health and environmental monitoring in remote regions, developing or developed countries.
At the interface: solvation and designing ionic liquids (2010)

Ionic liquids' (ILs) remarkable and tunable physicochemical properties mean they have distinct performance advantages over conventional solvents in many settings. However, the use of ILs in surface-dependent processes (e.g. electrodeposition, heterogeneous catalysis, dye solar cells) is hindered by the lack of a systematic understanding of IL interfacial structure. In this Perspective, we highlight recent experiments which show interfacial IL nanostructure is a consequence of both surface-specific and bulk liquid interactions. These results enable us to develop molecular design rules for controlling interfacial IL behavior.
On the biological role of histone acetylation (1990)

Research Article| January 01 1990 On the biological role of histone acetylation A Csordas A Csordas 1Institute of Medical Chemistry and Biochemistry, University of Innsbruck, A-6020 Innsbruck, Austria Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1990) 265 (1): 23–38. https://doi.org/10.1042/bj2650023 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation A Csordas; On the biological role of histone acetylation. Biochem J 1 January 1990; 265 (1): 23–38. doi: https://doi.org/10.1042/bj2650023 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1990 London: The Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
cDNA Cloning of MCT2, a Second Monocarboxylate Transporter Expressed in Different Cells than MCT1 (1995)

Low stringency screening of a cDNA library from hamster liver yielded a cDNA encoding MCT2, a monocarboxylate transporter that is 60% identical to hamster MCT1, the first monocarboxylate transporter to be isolated. The functional properties of the two MCTs were compared by expression in Sf9 insect cells using recombinant baculovirus vectors. Like MCT1, MCT2 transported pyruvate and lactate. The two transporters were sensitive to inhibition by phloretin and by alpha-cyano-4-hydroxycinnamate. MCT1, but not MCT2, was sensitive to organomercurial thiol reagents such as p-chloromercuribenzoic acid. Immunoblotting and immunofluorescence studies revealed a strikingly different tissue distribution of the two MCTs. MCT1 was present in erythrocytes and on the basolateral surfaces of intestinal epithelial cells. MCT2 was not detectable in these tissues, but it was abundant on the surface of hepatocytes. In the stomach, MCT1 was present on the basolateral surfaces of epithelial cells; in contrast, MCT2 was expressed on parietal cells of the oxyntic gland. In the kidney, MCT1 was present on the basolateral surfaces of epithelial cells in proximal tubules, whereas MCT2 was restricted to the collecting ducts. MCT1 was expressed on sperm heads in the testis and proximal epididymis. In the distal epididymis, it disappeared from sperm and appeared on the microvillar surface of the lining epithelium. In contrast, MCT2 was present on sperm tails throughout the epididymis and not on the epithelium. Both transporters were expressed in mitochondria-rich (oxidative) skeletal muscle fibers and cardiac myocytes. These findings suggest that MCT1 and MCT2 are adapted to play different roles in monocarboxylate transport in different cells of the body.
Variation in the electron count and ground state of [Mn12O12(O2CR)16(H2O)4](R = Me or Ph) by metal substitution and redox changes: preparation and properties of [Mn8Fe4O12(O2CMe)16(H2O)4]·4H2O·2MeCO2H and [NPrn4][Mn12O12(O2CPh)16(H2O)4]·H2O (1992)

As a means of varying the electron count of complexes [Mn12O12(O2CR)16(H2O)4](1; R = Me or Ph), the aggregates [Mn8Fe4O12(O2CMe)16(H2O)4]2 and [NPrn4][Mn12O12(O2CPh)16(H2O)4]3 have been prepared; magnetochemical measurements confirm that the unusual of properties 1 can be significantly altered by ‘conversion’ to 2 and 3.
Alkaloids of Dichroa febrifuga. I. Isolation and Degradative Studies (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloids of Dichroa febrifuga. I. Isolation and Degradative StudiesJ. B. Koepfli, J. F. Mead, and John A. BrockmanCite this: J. Am. Chem. Soc. 1949, 71, 3, 1048–1054Publication Date (Print):March 1, 1949Publication History Published online1 May 2002Published inissue 1 March 1949https://pubs.acs.org/doi/10.1021/ja01171a080https://doi.org/10.1021/ja01171a080research-articleACS PublicationsRequest reuse permissionsArticle Views388Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ubiquitous Computing: Extending Access To Mobile Data (1997)

CONTENTS DEDICATIONS iii LIST OF FIGURES vi SUMMARY vii CHAPTER I. INTRODUCTION 1 1.1 Thesis Statement 1 1.2 Problems With Current Solutions 2 1.3 Contributions 6 1.4 Overview of Remainder of Paper 7 II. RELATED WORK 9 2.1 Connectivity 9 2.2 Platform Assumptions 11 2.3 Application-Specific Effort 12 2.4 Data Integration 13 2.5 Summary 17 III. APPLICATIONS 18 3.1 Integrating Mobile Information into Desktop Applications 18 3.2 Collaboration among mobile devices 32 3.3 Summary 36 IV. ARCHITECTURE 37 4.1 Goals 37 4.2 Overview 39 4.3 Newton Overview 40 4.4 LlamaServer 43 4.5 MobileConnect 49 4.6 DesktopConnect 52 4.7 Intercomponent Communication 56 4.8 Summary 67 V. DESIGN DECISIONS, HURDLES, AND LIMITATIONS 68 5.1 Some information is kept permanently on the mobile device 69 v 5.2 Mobile devices always connected 71 5.3 Centralized server instead of point to point communications 73 5.4 Client applications explicitly written to handle mobile data 74 5.5 Assumes a homogeneous mobile
Alignment and self-assembly of elongated micronsize rods in several flow fields (2006)

Microfluidic alignment has attracted attention as a possible tool for the orientation of micronsize rods suspended in a solvent and the deposition of these rods in ordered arrays on solid surfaces. In the present work the following situations are realized experimentally: (i) a flow through an abruptly converging (or diverging) joint between wide and narrow straight channels which entrains and aligns (or misaligns) microrods and (ii) a tiny droplet of the order of a hundred microns that contains microrods is displaced due to Marangoni convection forces in a channel subjected to a temperature gradient. The flow near the advancing contact line orients the random suspension of rods and guides them towards the channel bottom where they are deposited in an ordered array. In parallel with this experimental study, the processes of microrod reorientation and alignment in the above-mentioned flows and in a similar sinklike flow into an issuing jet were studied using solutions of the Fokker-Planck equation for the orientation probability density function.
Myasthenia Gravis and its Animal Model: T Cell Receptor Expression in an Antibody Mediated Autoimmune Disease (1999)

Myasthenia gravis (MG) is a prototypic antibody-mediated autoimmune disease. Since the primary target antigen of the autoimmune response is known and a well-characterized animal model is available, MG is often considered an excellent situation for the application of novel specific immunotherapies, many of which are directed at T lymphocytes. CD4+ helper T cells are required for the development of the animal model, experimental autoimmune MG (EAMG). Even though the target antigen, acetylcholine receptor (AChR) is immunologically complex, the T cell response to AChR in mice is dominated by recognition of a single peptide by about 50% of the T cells. These T cells, in turn, utilize a restricted set of TCR gene elements and conserved CDR3 regions. While specific therapy directed at the immunodominant T cells is capable of reducing the magnitude of the anti-AChR response, considerable flexibility is apparent and reveals the ability of additional T cells to provide the requisite B cell help. In human MG patients, AChR-specific T cells have been identified but in many studies the frequencies were surprisingly low. In a very few cases, AChR-specific T cells have been cloned from MG patients. Analysis reveals heterogeneity in epitope recognition and MHC restriction. Little information on TCR structure is available. Our own studies using antigen-specific as well as non-specific methods for examining clonal T cell expansions in MG have led to an alternative hypothesis concerning T-B collaboration in MG.
Reliable Decision Support using Counterfactual Models (2017)

Decision-makers are faced with the challenge of estimating is likely to happen when they take an action. For instance, if I choose not to treat this patient, are they likely to die? Practitioners commonly use supervised learning algorithms to fit predictive models that help decision-makers reason about likely future outcomes, but we show that this approach is unreliable, and sometimes even dangerous. The key issue is that supervised learning algorithms are highly sensitive to the policy used to choose actions in the training data, which causes the model to capture relationships that do not generalize. We propose using a different learning objective that predicts counterfactuals instead of predicting outcomes under an existing action policy as in supervised learning. To support decision-making in temporal settings, we introduce the Counterfactual Gaussian Process (CGP) to predict the counterfactual future progression of continuous-time trajectories under sequences of future actions. We demonstrate the benefits of the CGP on two important decision-support tasks: risk prediction and what if? reasoning for individualized treatment planning.
Fluoropolyether coatings: relationship of electrochemical impedance spectroscopy measurements, barrier properties, and polymer structure (2002)

Ten model coatings, selected and obtained from a family of fluorinated resins synthesized by the reaction of perfluoroether oligomeric diols of different molec- ular weights with polyisocyanurates of hexamethylenediisocyanate (HDI) and isopho- ronediisocyanate (IPDI), were characterized with differential scanning calorimetry, mechanical testing, and electrochemical impedance spectroscopy measurements. The electrochemical and chemico-physical measurements show that the glass-transition temperature of the starting isocyanate trimers greatly influences the properties of the final urethane coatings; the IPDI trimer gives harder coatings with lower water per- meabilities than the corresponding HDI-based materials. Moreover, for each class of materials (from IPDI or HDI), the fluorine content plays a relevant role: the higher the fluorine percentage, the lower the water absorption into the coatings. Furthermore, the chain length of the polyols used for the synthesis of the prepolymers is a variable that exhibits great influence on the coating properties: coatings containing shorter perflu- oropolyether segments show better barrier properties. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part B: Polym Phys 40: 52–64, 2002
Inducible and irreversible control of gene expression using a single transgene (2000)

Experimental or therapeutic designs involving the conditional expression of genes often require the use of two different transgenes; this can represent a major undertaking. One of these systems takes advantage of inducible recombinases. Here we show a novel use of such enzymes, in that an inducible recombinase-encoding sequence can function to both block the transcription of a gene placed downstream and, subsequently, irreversibly activate transcription of this very same gene. This double function, which circumvents the need for two transgenes, can be achieved by flanking the inducible recombinase gene by two of its target sequences. In our design we used as the inducible recombinase gene the Cre-ER(T) gene flanked by two loxP sites. This cassette was placed between a mouse phosphoglycerate kinase promoter and the enhanced green fluorescent protein (EGFP) coding sequence. Massive EGFP gene expression in BHK cells bearing this transgene was observed upon administration of 4-hydroxytamoxifen (4-OHT), the inducer of the recombinant activity of Cre-ER(T). In the absence of 4-OHT EGFP production was prevented. Because of its simplicity (only a single transgene needs to be used) this strategy is of obvious interest in certain protocols of gene or cell therapy and in a variety of experimental designs in which conditional expression of genes is required.
Normal and Shear Force Measurement Using a Flexible Polymer Tactile Sensor With Embedded Multiple Capacitors (2008)

In this paper, we report a new flexible capacitive tactile sensor array with the capability of measuring both normal and shear force distribution using polydimethylsiloxane (PDMS) as a base material. A tactile cell consists of two thick PDMS layers with embedded electrodes, an air gap, and a pillar structure. The pillar structure is formed at the center of each tactile cell between the air gap under a large bump. There are four capacitors in a cell to decompose the contact force into normal and shear components. Four capacitors are arranged in a square form. If a normal force is applied on the bump, the PDMS layer on the pillar structure is compressed, and the air gap between the top and bottom electrodes decreases, resulting in the increase in all four capacitances. If a shear force is applied, a torque is induced around the pillar. Therefore, the capacitance of the two capacitors increases, whereas that of the other two decreases. The bump and the pillar structure play a critical role to generate a torque for shear force measurement. The sensor has been realized in an 8 x 8 array of unit sensors, and each unit sensor responds to normal and shear stresses in all three axes, respectively. Measurement of a single sensor shows that the full-scale range of detectable force is about 10 mN, which corresponds to 131 kPa in three directions. The sensitivities of a cell measured with a current setup are 2.5%/mN, 3.0%/mN, and 2.9 %/mN for the x-, y-, and z-directions, respectively. Normal and shear force images are also captured from a 4 x 4 array of the fabricated sensor. Distinctive characteristic patterns appear when a shear force is applied to the sensor.
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex (2010)

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot growth factor domain after processing. The structure of the PDGF-A/propeptide complex reveals this conserved, hydrophobic association mode. We also present the structure of the complex between PDGF-B and the first three Ig domains of PDGFRbeta, showing that two PDGF-B protomers clamp PDGFRbeta at their dimerization seam. The PDGF-B:PDGFRbeta interface is predominantly hydrophobic, and PDGFRs and the PDGF propeptides occupy overlapping positions on mature PDGFs, rationalizing the need of propeptides by PDGFs to cover functionally important hydrophobic surfaces during secretion. A large-scale structural organization and rearrangement is observed for PDGF-B upon receptor binding, in which the PDGF-B L1 loop, disordered in the structure of the free form, adopts a highly specific conformation to form hydrophobic interactions with the third Ig domain of PDGFRbeta. Calorimetric data also shows that the membrane-proximal homotypic PDGFRalpha interaction, albeit required for activation, contributes negatively to ligand binding. The structural and biochemical data together offer insights into PDGF-PDGFR signaling, as well as strategies for PDGF-antagonism.
Investigation of taxol as a potential radiation sensitizer (1993)

It appears that taxol has a radiation-sensitizing effect on HL-60 cells and deserves further investigation with other cell lines.
A Survey of Robot Tactile Sensing Technology (1989)

This paper reviews the current state-of-the-art in tactile sens ing technology. We examine in detail the different methods of transduction employed by tactile sensors and describe various significant designs that incorporate these methods. We then describe the different techniques used to process and analyze tactile data. Finally, we conclude with an assessment of the current state of development.
NONDESTRUCTIVE MEASUREMENT OF LONGITUDINAL RAIL STRESSES: APPLICATION OF THE ACOUSTOELASTIC EFFECT TO RAIL STRESS MEASUREMENT (1978)

An ultrasonic probe has been designed, evaluated and shown capable of measuring longitudinal stress changes in railroad rails. The probe utilizes the effect of applied stress on wave velocity (acoustoelastic effect) to determine the stress change. Both laboratory and field evaluation has shown that the probe is capable of measuring stress changes with an accuracy of plus or minus 6.9 MN sq m (plus or minus 1 ksi).
Synthetic control of a fitness tradeoff in yeast nitrogen metabolism (2009)

The ability to tune fitness and biological tradeoffs will be important components of future efforts to engineer microbial communities.
Triple-helix formation by oligodeoxynucleotides containing the carbocyclic analogs of thymidine and 5-methyl-2'-deoxycytidine (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTriple-helix formation by oligodeoxynucleotides containing the carbocyclic analogs of thymidine and 5-methyl-2'-deoxycytidineBrian C. Froehler and Daniel J. RiccaCite this: J. Am. Chem. Soc. 1992, 114, 21, 8320–8322Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00047a071https://doi.org/10.1021/ja00047a071research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
计算机技术的前景——兼评《2001年的技术:计算机和通讯技术的前景》 (1993)

IBM公司创始人T. J. 华斯顿在第二次世界大战结束时曾说过,“我认为只有一个需要大约5部计算机的世界市场”。1970年,即在个人电脑革命的前夜,数字设备公司的K.奥尔森也曾宣称,“任何人也没有必要在家里拥有一部计算机”。这就是预测计算机技术前景的危险。然而,由于有《2001年的技术:计算机和通讯技术的前景》这本有份量的书的诸位作者(他们大多数是美国领先的计算机公司的