gebhart/patrepeval huggingface dataset:
Mobile robot localization with sparse landmarks. (2001)

This paper describes a mobile robot system designed to explore and map an area such as is encountered in urban search and rescue simulations. The robot uses homogeneous artificial landmarks for localization as it builds metric and topological maps, determining landmark distance and bearing with groundplane calculations from a single camera and using Kalman filtering techniques to perform localization. When implemented on a Magellan II mobile robot, the localization technique correctly localized the robot while exploring and mapping.
Inflammatory cells in normal human fracture healing (1994)

We studied inflammatory cells in specimens of callus taken from normally healing human fractures. Using immunohistochemistry, T-cells, B-cells, macrophages, HLA-DR expression and endothelial proliferation were assessed. Macrophages were present from an early stage but became less numerous later. T-cells were initially specifically recruited into the fracture site at the stage of granulation tissue, but subsequently excluded from areas of bone and cartilage formation. Inflammatory cells may control and coordinate fracture healing as has been proposed for soft tissue wound healing. The most likely mechanism for this is by the cytokines and growth factors which they are known to release.
Marihuana: Identification of Cannabinoids by Centrifugal Chromatography (1971)

Components in extracts of marihuana and hashish have been identified by a chromatographic technique in which centrifugal force is used to accelerate the migration of samples through columns of densely packed microparticulate gel. Rapid qualitative analysis and an estimate of the amounts of cannabinoids present was achieved.
Mumps Vaccine Performance among University Students during a Mumps Outbreak (2008)

High 2-dose MMR coverage protected many students from developing mumps but was not sufficient to prevent the mumps outbreak. Vaccine-induced protection may wane. Similar US settings where large numbers of young adults from wild-type naive cohorts live closely together may be at particular risk for mumps outbreaks.
Further studies on the use of multi-substituted benzenesulfonyl groups for protection of the guanidino function of arginine. (1981)

Various multi-substituted benzenesulfonyl protecting groups for the guanidino function of arginine, removable under mild conditions such as with trifluoroacetic acid (TFA)-thioanisole, were studied. Among them, the 4-methoxy-2, 6-dimethylbenzenesulfonyl (Mds) group, the 2, 3, 4, 5, 6-pentamethylbenzenesulfonyl (Pme) group, and the 4-methoxy-2, 3, 6-trimethylbenzenesulfonyl (Mtr) group were found to be useful. Both Mds and Pme show considerable resistance to TFA and, therefore, are suitable for procedures in which the intermediates are deprotected by TFA treatment, while Mtr is the most useful protecting group when TFA treatment is not necessary.
Rational Design and Engineering of a Modified Adeno-Associated Virus (AAV1)-Based Vector System for Enhanced Retrograde Gene Delivery (2014)

This approach promises a significant advancement in the rational engineering of AAV vectors for diseases of the nervous system and other organs.
ECS Schemes for All Electric Airliners (1982)

&lt;div class="htmlview paragraph"&gt;This paper introduces the concepts and state-of-the-art advances on which the All-Electric Airliners will be based, discusses present practice and experience in the design of ECS and derives some ground rules and guidelines for generating new ECS schemes. Based on these, two examples of system schematic layout (Vapor Cycle and Recircair) are presented. Innovative development needed for execution of the systems is highlighted. The conclusion is that the systems are feasible and advantageous, but work on translating into practice should be started as soon as possible.&lt;/div&gt;
Role of Endothelin‐1 in Myocardial Failure (1999)

Endothelin-1 (ET-1) is a potent molecule produced throughout the cardiovascular system; it can exert important effects on both the structure and function of vascular smooth muscle cells and cardiac myocytes. ET-1 appears to play a central role in the physiological regulation of cardiovascular function, particularly in the vasculature. The known actions of ET-1 and the demonstration that plasma ET-1 is elevated in patients with heart failure has raised the possibility that this molecule could play a role in the pathophysiology of heart failure. This thesis has been supported and furthered by studies in animal models of heart failure that demonstrate the salutary, short-term effects of ET-1 receptor antagonists on hemodynamic function, as well as improved ventricular remodeling and survival with long-term administration. Early clinical trials with these ET receptor blockers have demonstrated systemic vasodilation. Long-term trials to determine the effects of ET-1 blockade on symptoms and survival are under way.
Distinct immunologic effects of different intravenous iron preparations on monocytes (2014)

Our findings demonstrate that specific immunologic effects of distinct i.v. iron preparations exist. The clinical relevance of these findings requires further investigation.
Muscarinic cholinergic receptors promote growth of human prostate cancer cells (1997)

M3 receptors stimulate the proliferation of LNCaP cells, BPH-derived and PC-derived primary prostate cells. A dramatically higher response to carbachol by PC-derived prostate cells suggests that M3 receptors may be up-regulated in PC. M3 receptors may play a significant role in PC tumors growth and androgen-independent tumor progression.
4 × 2 Tbit/s superchannel self‐coherent transmission based on carrier tracking and expanding (2014)

A novel superchannel transmission scheme is proposed where an optical comb source is used to carry the multiband signal and one subcarrier is reserved for regeneration as a local oscillator at the receiver end. By combining carrier tracking and carrier expanding, a 4 × 2 Tbit/s superchannel wavelength division multiplexed self‐coherent transmission over a 320 km standard single mode fibre has been successfully demonstrated.
Splanchnic and Peripheral Disposal of Oral Glucose in Man (1983)

Oral glucose (92 g) was administered to 22 healthy, young volunteers undergoing hepatic vein catheterization, and net splanchnic glucose output (SGO) was measured during the basal period and for 4 h after glucose ingestion. In the basal state, SGO averaged 1.90 +/- 0.11 mg/min X kg. After glucose, SGO rose to a peak value of 6.65 +/- 0.83 mg/min X kg at 30 min and returned to baseline by 3 h. Total SGO over 4 h was 69 +/- 4 g; assuming complete absorption of the load, this amount represented 75% of the oral glucose. In a subgroup of six subjects, leg glucose uptake was simultaneously quantitated by femoral vein catheterization and leg blood flow measurement. In the postabsorptive state, glucose uptake by one leg was 24 +/- 8 mg/min and increased to a mean value of 76 +/- 7 mg/min during the 4 h after glucose ingestion. Overall, 18 +/- 2 g/4 h of glucose were taken up by one leg, which extrapolates to a total body muscle uptake of 65 +/- 4 g over 4 h. We conclude that in normal man, well over 2/3 of an oral glucose load escapes splanchnic removal, and that the peripheral tissues quantitatively play the dominant role in glucose disposal.
A 0.7W fully integrated 42GHz power amplifier with 10% PAE in 0.13&#x00B5;m SiGe BiCMOS (2013)

In this paper, we report a fully integrated power amplifier (PA) architecture that combines the power of 16 on-chip PAs using a 16-way zero-degree combiner to achieve an output power of 0.7W with a power-added efficiency (PAE) of 10% at 42GHz and a -3dB bandwidth of 9GHz. This is 2.6 times more output power than a recently reported millimeter-Wave (mm-Wave) silicon-based PA [1]. The circuit is a fully integrated mm-Wave PA achieving a leading output power approaching 1 Watt in a silicon process.
Renal folate absorption and the kidney folate binding protein. II. Microinfusion studies (1987)

Surface proximal convoluted tubules (PCT) in rats were microinfused in situ with [3H]folic acid to study the role of folate binding protein (FBP) in the kidney brush-border membrane for renal conservation and transport of folate [3H]folic acid absorption was linearly related to tubular length of PCT and occurred largely in this segment of the tubule. Unlabeled folate derivatives inhibited [3H]folic acid absorption, the extent of which was dependent on the type of unlabeled folate used and its concentration. At equivalent concentrations, inhibition was most effective with unlabeled folic acid, slightly lower than with 5-methyltetrahydrofolate and least effective with methotrexate. Comparisons between [3H]folic acid absorption before and after infusion of a saturating dose of unlabeled folic acid or repetitive injections of [3H]folic acid into the same tubular site revealed continuous and rapid regeneration of unsaturated folic acid uptake sites with an apparent half-life of 28.75 +/- 8.75 s. Determination of [3H] retained in the tubule at various periods after microinfusion of [3H]folic acid revealed slow cellular disappearance with an apparent half-life of 47.3 +/- 5.4 min. It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Internalized folic acid is slowly released into renal capillaries.
Second‐ and third‐trimester serum levels of placental proteins in preeclampsia and small‐for‐gestational age pregnancies (2003)

The reduced serum levels of the placental proteins PAPP-A, SP1 and HPL in the early second trimester (17 weeks) in pregnancies with subsequent preeclampsia or with fetal growth restriction involve an underlying role for the placenta in either pathology independent from the other.
A comparison of the biological activities of wild‐type and mutant p53 (1993)

Tumorigenesis is characterized by a series of genetic alterations in both dominant oncogenes and tumor suppressor genes. A hallmark of tumor suppressor genes is that both alleles are generally altered during transformation, which usually represents a loss of function phenotype. The p53 tumor suppressor gene is the most frequently affected gene detected in human cancer. There is now growing evidence suggesting that mutation of p53 may involve not only a loss of function of wild-type p53 activity but also a gain of function phenotype contributed by the mutant p53 protein. The study of the biological properties and functions of both wild-type and mutant p53 is central to our understanding of human cancer. These properties and functions of wild-type and mutant p53 will be compared and contrasted here and elsewhere within this thematic issue. In addition, the mechanisms of inactivation of p53 function, which include: 1) mutation, 2) inhibition by viral oncogene products, 3) inhibition by cellular regulators, and 4) alteration in subcellular localization, will be discussed.
Herpes simplex virus-2 transmission probability estimates based on quantity of viral shedding (2014)

Herpes simplex virus (HSV)-2 is periodically shed in the human genital tract, most often asymptomatically, and most sexual transmissions occur during asymptomatic shedding. It would be helpful to identify a genital viral load threshold necessary for transmission, as clinical interventions that maintain viral quantity below this level would be of high utility. However, because viral expansion, decay and re-expansion kinetics are extremely rapid during shedding episodes, it is impossible to directly measure genital viral load at the time of sexual activity. We developed a mathematical model based on reproducing shedding patterns in transmitting partners, and median number of sex acts prior to transmission in discordant couples, to estimate infectivity of single viral particles in the negative partner's genital tract. We then inferred probability estimates for transmission at different levels of genital tract viral load in the transmitting partner. We predict that transmission is unlikely at viral loads less than 10(4) HSV DNA copies. Moreover, most transmissions occur during prolonged episodes with high viral copy numbers. Many shedding episodes that result in transmission do not reach the threshold of clinical detection, because the ulcer remains very small, highlighting one reason why HSV-2 spreads so effectively within populations.
Interphase molecular cytogenetic analysis of epithelial ovarian carcinomas. (1993)

Karyotype information on ovarian carcinomas has been limited because the tumors are often difficult to culture and the resultant metaphases can have complex numerical and structural chromosomal anomalies. Fluorescent in situ hybridization is a rapid method of determining centromere copy number in metaphase cells and interphase nuclei. Fluorescent in situ hybridization was used to determine the numerical centromere complement of chromosomes X, 8, 12, and 17 and HER-2/neu gene amplification within interphase nuclei of 25 primary epithelial ovarian carcinomas. Touch preparations of the carcinomas were hybridized with two-color combinations of directly labeled alpha-satellite centromeric chromosome enumeration probes and a directly labeled HER-2/neu probe. Modal centromere copy numbers for each of the four chromosomes were used to determine numerical abnormalities relative to the flow cytometric DNA ploidy level for each tumor. Four cases were found to be normal with respect to the four chromosomes studied. In the remaining 21 cases a relative loss of chromosomes 17 (16 cases) and X (nine cases) and a relative gain of chromosomes 12 (10 cases) and 8 (nine cases) were the most common findings. In addition, the HER-2/neu gene was amplified in two of the 25 tumors. In conclusion, fluorescent in situ hybridization is an excellent method for rapid determination of numerical abnormalities and gene amplification in ovarian carcinomas.
Stem Cell-Derived Cardiomyocytes Demonstrate Arrhythmic Potential (2002)

ESCs or ECCs differentiated into at least 3 AP phenotypes. CMs showed spontaneous activity, low dV/dt, prolonged AP duration, and easily inducible triggered arrhythmias. These findings raise caution about the use of totipotent ESCs in cell transplantation therapy, because they may act as an unanticipated arrhythmogenic source from any of the 3 classic mechanisms (reentry, automaticity, or triggered activity).
Real-Time PCR Coupled with Automated DNA Extraction and Detection of Galactomannan Antigen in Serum by Enzyme-Linked Immunosorbent Assay for Diagnosis of Invasive Aspergillosis (2002)

To improve the diagnosis of invasive aspergillosis (IA), we developed a LightCycler PCR assay targeted to Aspergillus fumigatus and A. flavus mitochondrial DNA. To avoid contamination, fully automated nucleic acid extraction with the MagNA Pure LC apparatus was used. The linearity of the results was achieved over a 6-log range of input A. fumigatus DNA, from 0.3 ng to 3 fg/10 microl of water. We retrospectively compared the LightCycler PCR and an enzyme-linked immunosorbent assay for the detection of galactomannan (GM) in serum from 14 patients with IA. The GM assay was more frequently positive (57 of 109; 52%) than the PCR assay (49 of 109; 45%). The LightCycler PCR assay, combined with automated DNA extraction, could be used in association with the GM assay to improve the reliability of IA diagnosis.
Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients (1994)

Journal Article Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients Get access Vladimir Lazar, Vladimir Lazar 1Services d'lmmunologie Moléculaire, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex Search for other works by this author on: Oxford Academic PubMed Google Scholar Sophie Grandjouan, Sophie Grandjouan 2Gastro-entérologie, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex4Service d'Hépato-Gastroenterologie, Hôpital Cochin27 rue du Faubourg Saint-Jacques, 75014 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar Caroline Bognel, Caroline Bognel 3d'Anatomie-Pathologie B, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel Couturier, Daniel Couturier 4Service d'Hépato-Gastroenterologie, Hôpital Cochin27 rue du Faubourg Saint-Jacques, 75014 Paris Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Rougier, Philippe Rougier 2Gastro-entérologie, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex Search for other works by this author on: Oxford Academic PubMed Google Scholar Dominique Bellet, Dominique Bellet 1Services d'lmmunologie Moléculaire, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex5Laboratoire d'lmmunologie des Tumeurs, URA CNRS 1484, Faculté des Sciences Pharmaceutiques et Biologiques de Paris75006 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Brigitte Bressac-de Paillerets Brigitte Bressac-de Paillerets * 1Services d'lmmunologie Moléculaire, Institut Gustave Roussy39 rue Camille Desmoulins, 94805 villejuif Cedex * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 3, Issue 12, December 1994, Pages 2257–2260, https://doi.org/10.1093/hmg/3.12.2257 Published: 01 December 1994 Article history Received: 18 August 1994 Accepted: 29 September 1994 Published: 01 December 1994
Mutations in the C terminus of herpes simplex virus type 1 DNA polymerase can affect binding and stimulation by its accessory protein UL42 without affecting basal polymerase activity (1993)

We have analyzed the effects of mutations in the herpes simplex virus type 1 DNA polymerase (Pol) C-terminal UL42 binding domain on the activity of Pol and its ability to form complexes with and be stimulated by UL42 in vitro. Wild-type Pol expressed in Saccharomyces cerevisiae was both bound and stimulated by UL42 in vitro. C-terminal truncations of 19 and 40 amino acids (aa) did not affect the ability of Pol to be stimulated by UL42 in vitro. This stimulation as well as basal Pol activity in the presence of UL42 was inhibited by polyclonal anti-UL42 antiserum, thus indicating a physical interaction between Pol and UL42. Removal of the C-terminal 59 aa of Pol and internal deletions of 72 aa within the Pol C terminus eliminated stimulation by UL42. None of the truncations or deletions within Pol affected basal polymerase activity. In contrast with their ability to be stimulated by UL42, only wild-type Pol and Pol lacking the C-terminal 19 aa bound UL42 in a coimmunoprecipitation assay. These results demonstrate that a functional UL42 binding domain of Pol is separable from sequences necessary for basal polymerase activity and that the C-terminal 40 aa of Pol appear to contain a region which modulates the stability of the Pol-UL42 interaction.
A Fully Integrated Analog Compensation for the Piezo-Hall Effect in a CMOS Single-Chip Hall Sensor Microsystem (2014)

A magnetic sensor microsystem with Hall plates, temperature sensor, and stress sensor designed for the purpose of temperature-dependent piezo-Hall effect compensation has been implemented in 0.35μm CMOS technology. The sensor microsystem as well as the compensation method is entirely realized in integrated analog circuitry. A dedicated stress sensor delivers a signal proportional to the sum of in-plane normal stresses. At the systems level, the analog circuit compensates the stress-related drift of the magnetic sensitivity by adding a current proportional to the stress sensor signal on top of the Hall plate supply current. After a three-temperature calibration of a sensor molded in a SOIC-8 package extending from -40 °C to +125 °C, the residual thermal drift of the magnetic sensitivity was reduced to <;0.5%. The stress-related drift due to a humidity change from humid to dry was reduced to <;0.6% for samples packaged in SOIC-8 and single-in-line molded packages.
ERK Inhibitors as a Potential New Therapy for Rheumatoid Arthritis (2008)

Rheumatoid arthritis (RA), a chronic and systemic autoimmune disease that leads to progressive articular destruction, is evoked by the concerted action of RA-related cells, such as T cells, synovial fibroblasts and macrophages. Although anticytokine biologics block the intercellular signal transduction of these RA-related cells and thereby exert a strong ameliorative effect on RA, there still remains a significant percentage of nonresponsive patients. In addition to these biologics that disrupt specific intercellular signals, extracellular signal-regulated kinase (ERK) inhibitors, which are believed to target the intracellular signals common to the diverse RA-related cells, are also used as a treatment for RA patients, including those who are nonresponsive to the anticytokine therapies. Recently, potent and selective inhibitors for ERK with the co-crystal structures have been reported. FR180204, an ERK inhibitor, has been shown to be effective against mouse collagen-induced arthritis, a representative animal model of RA. This compound also suppresses the antigen-specific activation of T cells, which play a central role in the initiation and progress of the disease. Information obtained from the co-crystal structures would contribute to the improvement of the chemical characteristics. Thus, with the discovery of new potential chemical entities, ERK inhibitors may emerge as a new therapeutic approach for the treatment of RA.
Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6. (1991)

Liver fat-storing cells (FSC) play an important role in collagen deposition. During the induction of liver cirrhosis, FSC lose their fat droplets, acquire an actin-rich cytoskeleton and transform into myofibroblasts. Myofibroblasts have been associated with increased collagen production in cirrhotic livers. Cultured FSC resemble myofibroblasts. However, it is not known whether regulation of collagen gene expression is similar in FSC obtained from normal or cirrhotic livers. In this communication, we describe the characterization of two fat-storing cell lines, one from normal (NFSC) and one from CCl4-cirrhotic liver (CFSC), obtained after spontaneous immortalization in culture. We studied the effect of serum and various growth factors on cell proliferation. We determined the production of collagen and fibronectin and we analyzed the presence of mRNA transcripts of collagens type I, III, and IV, fibronectin laminin, transforming growth factor-beta and interleukin-6. We found that CFSC have a greater serum-dependency than NFSC. NFSC grow with a mixture of insulin and epidermal growth factor, whereas CFSC proliferate only with platelet-derived growth factor. Although we did not find significant differences in the expression of mRNAs for collagen type I, fibronectin and transforming growth factor-beta, collagen and fibronectin synthesis was increased 2- and 1.5-fold respectively. NFSC contained 1.6- and 2.0-fold more type III collagen and laminin mRNAs, respectively, than CFSC. Neither cell line expressed type IV collagen mRNA. NFSC but not CFSC produced interleukin-6. These results suggest that, except for the lack of transcripts of collagen type IV, both cell lines resemble primary cultures of FSC. However, significant differences in cell proliferation and interleukin-6 production between the two cell lines were found. We suggest that these cell lines could be useful tools to study possible differences in regulation of matrix production by FSC.
A prostate stem cell antigen‐derived peptide immunogenic in HLA‐A24− prostate cancer patients (2004)

The PSCA 76-84 peptide should be considered for use in clinical trials of immunotherapy for HLA-A24+ patients.