gebhart/patrepeval huggingface dataset:
LETTERS TO THE EDITOR (1989)

LETTERS TO THE EDITOR Get access M.L. PLANT, M.L. PLANT Gastrointestinal Unit, Charing Cross Hospital (Fulham)Fulham Palace Road, London W6 8RF Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. PLANT, M.A. PLANT Gastrointestinal Unit, Charing Cross Hospital (Fulham)Fulham Palace Road, London W6 8RF Search for other works by this author on: Oxford Academic PubMed Google Scholar IAIN MURRAY-LYON, IAIN MURRAY-LYON Gastrointestinal Unit, Charing Cross Hospital (Fulham)Fulham Palace Road, London W6 8RF Search for other works by this author on: Oxford Academic PubMed Google Scholar JAN WATERSON JAN WATERSON Gastrointestinal Unit, Charing Cross Hospital (Fulham)Fulham Palace Road, London W6 8RF Search for other works by this author on: Oxford Academic PubMed Google Scholar Alcohol and Alcoholism, Volume 24, Issue 4, 1989, Pages 355–356, https://doi.org/10.1093/oxfordjournals.alcalc.a044922 Published: 01 July 1989
Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. (1991)

Immediate post-training intracerebroventricular administration of a synthetic peptide homologous to beta protein of brain amyloid, [Gln11]beta-(1-28), caused amnesia for footshock active avoidance training in mice in a dose-dependent fashion. This effect was specific to memory processing since the peptide did not cause amnesia when injected 24 hr after training nor did it disturb storage or retrieval of older memories. Shorter fragments of the amyloid beta protein consisting of residues 12-28, 18-28, and 12-20 also were amnestic when given intracerebroventricularly, residues 12-20 being least effective. The hippocampus, a brain structure importantly involved in learning and memory, consistently shows severe pathological changes and deposition of amyloid in patients with Alzheimer disease. Immediate post-training bilateral intrahippocampal injection of [Gln11]beta-(1-28) produced amnesia at much lower doses than did [Gln11]beta-(1-28) injected intracerebroventricularly. Thus these experimental results suggest a possible direct role of amyloid beta protein or fragments thereof in an aspect of the spectrum of cognitive deficit in Alzheimer disease.
Tertiary amine solvents having switchable hydrophilicity (2011)

Several tertiary amines serve as switchable-hydrophilicity solvents, meaning that they are hydrophobic solvents having very low miscibility with water when under air but hydrophilic solvents having complete miscibility with water when under an atmosphere of CO2. Unlike the only previously reported switchable-hydrophilicity solvent, these amines are easily prepared and, in some cases, commercially available. The effect of temperature, gas flow rates, choice of amine and additives on the switching process is described. These solvents can be applied to the recycling of polystyrene foam.
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells. (1992)

To determine whether the gene encoding the recently identified heparin-binding epidermal growth factor-like growth factor (HB-EGF), a potent smooth muscle cell (SMC) mitogen of macrophage origin, is transcribed and regulated in vascular SMC, we isolated cDNA clones encoding rat HB-EGF from a macrophage library. Using the rat HB-EGF cDNA as a probe for RNA blot analysis, we detected low levels of HB-EGF mRNA in rat aortic SMC in culture. However, 20 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) and 10(-6) M angiotensin II (AII) induced a marked increase in HB-EGF mRNA levels in rat aortic SMC (11- and 4.6-fold, respectively) that was both dose- and time-dependent. In response to TPA and AII, HB-EGF mRNA levels increased rapidly, peaked at 2 h, and returned to base line at 7 h. This effect of AII on HB-EGF induction was specific, as evidenced by the fact that it could be completely blocked by the AII antagonist saralasin. This is the first demonstration that HB-EGF is transcribed and regulated in SMC. The inducible transcription of this potent SMC mitogen gene in vascular SMC suggests that HB-EGF may have an important autocrine role in the proliferation of SMC in vascular diseases such as atherosclerosis and hypertension.
Use of high-temperature superconductors in high speed electronic switches with current gain (1988)

Recent developments in superconductivity have taken 77 K superconducting electronics from a dream to a likelihood. Rather than following the conventional path by developing Josephson junction-based devices, this paper discusses the unique possibilities of hybrid superconductor/semiconductor devices. The two devices discussed are a true three-terminal hybrid resonant tunneling transistor and the semiconductor-coupled Josephson junction. Also, a list is given of as yet uninvestigated issues concerning the new superconductors and their proximity effects with semiconductors -issues that are critical to the operation of these hybrid superconductor/semiconductor devices.
Synaptogenesis and myelination in dissociated cerebral microcarrier cell cultures (1983)

A new approach for cultivating dissociated cerebral neurons is described. It is based on a rapid attachment of neurons to the DEAE-cellulose cylindrical MC and their subsequent interconnection to form cell-MC conglomerates. Intensive fiber growth followed by synaptogenesis and progressive myelin formation are indicative of optimal conditions of nutrition and oxygenation.
A Multigene Expression Assay to Predict Local Recurrence Risk for Ductal Carcinoma In Situ of the Breast (2013)

The DCIS Score quantifies IBE risk and invasive IBE risk, complements traditional clinical and pathologic factors, and provides a new clinical tool to improve selecting individualized treatment for women with DCIS who meet the ECOG E5194 criteria.
Isolation and Characterization of Sulfated Disaccharides from the Deamination Products of Porcine Heparin (α-Heparin) and Whale Heparin (ω-Heparin), and a Comparison of the Deamination Products1 (1978)

Porcine heparin (α-heparin) and whale heparin (ω-heparin) were deaminated, and sulfated disaccharides, compounds b-2, e-2-1, e-2-2, and e-2-3 from the former and compounds b′-2 and e′-2-l from the latter, were isolated from these products by high-voltage paper electrophoresis, gel filtration on Sephadex G-25 and column chromatography on Dowex 1x2 (Cl− form) in succession. Based on the results of chemical, GLC and p.m.r. spectral analyses, together with previous observations, the structures of these sulfated disaccharides are proposed to be as follows: compounds b-2 and b′-2, 4-0-(cr-L-idopyranosyluronic acid 2-sulfate)-2,5-anhydro-D-mannose 6-sulfate; compounds e-2-1 and e′-2-l, 4-O-(a-L-idopyranosyluronic acid 2-sulfate)-2,5-anhydro-D-mannose; compound e-2-2, 4-0-{β-D-glucopyranosyluronic acid)-2,5-anhydro-D-mannose 6-sulfate; compound e-2-3, 4-0-{a-L-idopyranosyluronic acid)-2,5-anhydro-D-man-nose 6-sulfate. A high-voltage paper electrophoretogram of the deamination products of a-heparin was compared with a similar electrophoretogram of those of co-heparin. Except for fraction a from the former, both deamination products were composed of seven corresponding fractions, though they differed strikingly in their proportions. The proportion of higher oligosaccharides to disaccharides was smaller in the case of a-heparin than in that of co-heparin, reflecting the higher content of 2-acetamido-2-deoxy-D-glucose residues in the latter. The greatest difference was found in disaccharide fractions. The major fraction in a-heparin was disulfated disac-charide, compound b-2, whereas that in co-heparin was monosulfated disaccharide, compound e′-2-l. The present results indicate a lower content of 6-O-sulfated 2-amino-2-deoxy-D-glucose in co-heparin than in a-heparin. It is suggested therefore that a portion of 6-O-sulfates does not contribute significantly to the anticoagulant activity of heparin, since co-heparin has a higher activity than α-heparin.
Tamoxifen retards glycosphingolipid metabolism in human cancer cells (1996)

In this study we provide evidence that tamoxifen, the widely used breast cancer drug, is a potent antagonist of glycolipid metabolism. When added to the medium of cultured multidrug resistant (MDR) KB-V-1 carcinoma cells, tamoxifen, at 5.0 microM, drastically lowered the levels of glucosylceramide (glc-cer), as evidenced by a reduction in glc-cer mass. In a similar fashion, in cultured human melanoma cells grown with [3H]galactose, tamoxifen inhibited formation of glc-cer by 44%, and retarded lactosylceramide and ganglioside formation by 50 and 35%, respectively. When glc-cer synthase of melanoma was assayed in cell-free incubations, the inclusion of tamoxifen, at a 1:10 molar ratio with ceramide, inhibited glc-cer synthesis by 50%. These results clearly reveal a new action of tamoxifen and thereby pose intriguing questions regarding mechanisms of action in the realm of estrogen receptor-independent modalities, including effects on MDR.
[Relationship between AKAP95, cyclin E1, cyclin D1, and clinicopathological parameters in lung cancer tissue]. (2013)

Cyclin E1 and cyclin D1 are highly expressed in lung cancer tissue, suggesting that they play an important role in the development and progression of lung cancer. The protein expression of cyclin E1 has no relationship with cellular differentiation, lymph node metastasis, and histopathological type of lung cancer, and the protein expression of cyclin D1 has a significant relationship with histopathological type. The expression of AKAP95 is correlated with the protein expression of cyclin E1 and cyclin D1 in lung cancer tissue.
Release of indomethacin from a novel chitosan microsphere prepared by a naturally occurring crosslinker: Examination of crosslinking and polycation–anionic drug interaction (2001)

Abstract Novel chitosan microspheres with lower cytotoxicity were fabricated in this study and their drug release characteristics were investigated. Genipin, a naturally occurring crosslinking reagent that has been used in herbal medicine and in the production of food dye, was used to prepare crosslinked chitosan microspheres by a water‐in‐oil dispersion method. The crosslinking mechanism examined by FTIR and 13 C–NMR suggests that the crosslinking of chitosan by genipin leads to the formation of secondary amide and heterocyclic amino linkage. The polycation–anionic drug interaction between chitosan and indomethacin was pH dependent and could affect the dissolution property of indomethacin. By examination of the release profiles of the crosslinked chitosan microsphere, it was found that the release of indomethacin from the microsphere was sustainable and influenced by factors such as crosslinking of microsphere and chitosan–indomethacin interaction, thus establishing crosslinked chitosan microsphere as a very promising polymeric carrier for drug release. © 2001 John Wiley &amp; Sons, Inc. J Appl Polym Sci 81: 1700–1711, 2001
Replication and Control of Circular Bacterial Plasmids (1998)

An essential feature of bacterial plasmids is their ability to replicate as autonomous genetic elements in a controlled way within the host. Therefore, they can be used to explore the mechanisms involved in DNA replication and to analyze the different strategies that couple DNA replication to other critical events in the cell cycle. In this review, we focus on replication and its control in circular plasmids. Plasmid replication can be conveniently divided into three stages: initiation, elongation, and termination. The inability of DNA polymerases to initiate de novo replication makes necessary the independent generation of a primer. This is solved, in circular plasmids, by two main strategies: (i) opening of the strands followed by RNA priming (theta and strand displacement replication) or (ii) cleavage of one of the DNA strands to generate a 3'-OH end (rolling-circle replication). Initiation is catalyzed most frequently by one or a few plasmid-encoded initiation proteins that recognize plasmid-specific DNA sequences and determine the point from which replication starts (the origin of replication). In some cases, these proteins also participate directly in the generation of the primer. These initiators can also play the role of pilot proteins that guide the assembly of the host replisome at the plasmid origin. Elongation of plasmid replication is carried out basically by DNA polymerase III holoenzyme (and, in some cases, by DNA polymerase I at an early stage), with the participation of other host proteins that form the replisome. Termination of replication has specific requirements and implications for reinitiation, studies of which have started. The initiation stage plays an additional role: it is the stage at which mechanisms controlling replication operate. The objective of this control is to maintain a fixed concentration of plasmid molecules in a growing bacterial population (duplication of the plasmid pool paced with duplication of the bacterial population). The molecules involved directly in this control can be (i) RNA (antisense RNA), (ii) DNA sequences (iterons), or (iii) antisense RNA and proteins acting in concert. The control elements maintain an average frequency of one plasmid replication per plasmid copy per cell cycle and can "sense" and correct deviations from this average. Most of the current knowledge on plasmid replication and its control is based on the results of analyses performed with pure cultures under steady-state growth conditions. This knowledge sets important parameters needed to understand the maintenance of these genetic elements in mixed populations and under environmental conditions.
Role of insulin-like growth factors and myogenin in the altered program of proliferation and differentiation in the NFB4 mutant muscle cell line. (1995)

In the present study we used the mutant muscle cell line NFB4 to study the balance between proliferation and myogenic differentiation. We show that removal of serum, which induced the parental C2C12 cells to withdraw from the cell cycle and differentiate, had little effect on NFB4 cells. Gene products characteristic of the proliferation state, such as c-Jun, continued to accumulate in the mutant cells in low serum, whereas those involved in differentiation, like myogenin, insulin-like growth factor II (IGF-II), and IGF-binding protein 5 (IGFBP-5) were undetectable. Moreover, NFB4 cells displayed a unique pattern of tyrosine phosphorylated proteins, especially in low serum, suggesting that the signal transduction pathway(s) that controls differentiation is not properly regulated in these cells. Treatment of NFB4 cells with exogenous IGF-I or IGF-II at concentrations shown to promote myogenic differentiation in wild-type cells resulted in activation of myogenin but not MyoD gene expression, secretion of IG-FBP-5, changes in tyrosine phosphorylation, and enhanced myogenic differentiation. Similarly, transfection of myogenin expression constructs also enhanced differentiation and resulted in activation of IGF-II expression, showing that myogenin and IGF-II cross-activate each other's expression. However, in both cases, the expression of Jun mRNA remained elevated, suggesting that IGFs and myogenin cannot overcome all aspects of the block to differentiation in NFB4 cells.
Three-dimensional structure of an intact human immunoglobulin. (1977)

We have examined the low-resolution structure of a complete human IgG1 using known domain coordinates from crystallographic investigations of immunoglobulin fragment structures. Our results indicate that the Fc portion of this molecule has a structure similar to that of an isolated Fc fragment, with the carbohydrate moiety playing a central role as the principal contact between the CH2 domains. Carbohydrate also forms a large part of the interface between the Fc and Fab regions. The relative orientations of the variable and constant portions of the Fab regions are intermediate between those reported previously, emphasizing the flexibility of the switch region. These data do not support a two-state allosteric model such as has been proposed for antibody effector functions.
Self-testable accelerometer systems (2003)

A novel approach to producing a high-reliability silicon accelerometer is described. The approach relies on the electrostatic deflection of the micromachined silicon mass. A number of key advantages result from this configuration. Even though the spring constants of the device may vary from unit to unit or over temperature, and even though the piezoresistive coefficients vary over temperature, as long as the electrostatic voltage and initial separation gap are held constant, the output is proportional to a given acceleration. Applications of this technology are in temperature compensation, testability and unidirectional force-balance applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Antimitotic Agents: Effects on Double Haploid Production in Wheat (1991)

Chromosome doubling of microspore‐derived plantlets and calli is a critical step in haploid breeding programs. For anther culture experiments, colchicine, ( S )‐ N ‐(5,6,7,9‐tetrahydro‐l,2,3,10‐tetramethoxy‐9‐oxobenzo[a]heptalen‐7‐yl)acetamide, is the most commonly used compound in doubling the chromosomes of seedlings derived from such experiments. Colchicine, however, is carcinogenic and expensive. We evaluated three antimitotic agents (colchicine; trifluralin, 2,6‐dinitro‐ N,N ‐dipropyl‐4‐(trifluoromethyl)benzenamine; and oryzalin, 4‐(dipropylamino)‐3,5‐dinitrobenzenesulfonamide) at two treatment durations (48 and 72 h) and two concentrations [colchicine at 0.0125% (313 μ M ) and 0.025% (626 μ M ), and both trifluralin and oryzalin at 5 and 10 μ M each for their effects on the production of double haploids from anther‐derived calli of two wheat [ Triticum aestivum (L.) em. Thell.] cultivars, Pavon and Kitt. Calli from Pavon were more responsive to the three agents than those from Kitt. Colchicine was the most effective in double the chromosome number. for Pavon, 89% of the plantlets from calli treated with colchicine were double haploids (2 n = 6 x = 42). However, treating calli for 72 h with colchicine at either concentration had a deleterious effect. No significant differences were observed between concentrations of any of the antimitotic agents. All the plantlets produced from the control treatment (without antimitotic agents) were polyhaploids (2 n = 3 x = 21). These results indicated that colchicine is still the most ffective compound for chromosome doubling, and colchicine treatment of anther‐derived calli is an effective method of obtaining a high frequency of double haploid plantlets through anther culture systems.
Managing geo-distributed stream processing pipelines for the IIoT with StreamPipes edge extensions (2020)

The industrial IoT and its promise to realize data-driven decision-making by analyzing industrial event streams is an important innovation driver in the industrial sector. Due to an enormous increase of generated data and the development of specialized hardware, new decentralized paradigms such as fog computing arised to overcome shortcomings of centralized cloud-only approaches. However, current undertakings are focused on static deployments of standalone services, which is insufficient for geo-distributed applications that are composed of multiple event-driven functions. In this paper, we present StreamPipes Edge Extensions (SEE), a novel contribution to the open source IIoT toolbox Apache StreamPipes. With SEE, domain experts are able to create stream processing pipelines in a graphical editor and to assign individual pipeline elements to available edge nodes, while underlying provisioning and deployment details are abstracted by the framework. The main contributions are (i) a fog cluster management model to represent computing node characteristics, (ii) a node controller for pipeline element life cycle management and (iii) a management framework to deploy event-driven functions to registered nodes. Our approach was validated in a real industrial setup showing low overall overhead of SEE as part of a robot-assisted product quality inspection use case.
THEORIES OF UNIMOLECULAR GAS REACTIONS AT LOW PRESSURES (1927)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHEORIES OF UNIMOLECULAR GAS REACTIONS AT LOW PRESSURESOscar Knefler Rice and Herman C. RamspergerCite this: J. Am. Chem. Soc. 1927, 49, 7, 1617–1629Publication Date (Print):July 1, 1927Publication History Published online1 May 2002Published inissue 1 July 1927https://doi.org/10.1021/ja01406a001RIGHTS & PERMISSIONSArticle Views1231Altmetric-Citations363LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (685 KB) Get e-Alertsclose Get e-Alerts
Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system (2017)

Pacemakers have existed for decades as a means to restore cardiac electrical rhythms. However, lead-related complications have remained a clinical challenge. While market-released leadless devices have addressed some of the issues, their pacer-integrated batteries cause new health risks and functional limitations. Inductive power transfer enables wireless powering of bioelectronic devices; however, Specific Absorption Rate and size limitations reduce power efficiency for biomedical applications. We designed a remote-controlled system in which power requirements were significantly reduced via intermittent power transfer to control stimulation intervals. In parallel, the cardiac component was miniaturized to facilitate intravascular deployment into the anterior cardiac vein. Given size constraints, efficiency was optimal via a circular receiver coil wrapped into a half-cylinder with a meandering tail. The pacemaker was epicardially tested in a euthanized pig at 60 beats per minute, 2 V amplitude, and 1 ms pulse width, restoring mean arterial pressure from 0 to 37 mmHg. Power consumption was 1 mW at a range of > 3 cm with no misalignment and at 2 cm with 45° displacement misalignment, 45° x-axis angular misalignment, or 45° y-axis angular misalignment. Thus, we demonstrated a remote-controlled miniaturized pacing system with low power consumption, thereby providing a basis for the next generation of wireless implantable devices.
IANA Allocation Guidelines For Values In the Internet Protocol and Related Headers (2000)

This memo provides guidance for the IANA to use in assigning parameters for fields in the IPv4, IPv6, ICMP, UDP and TCP protocol headers.
Cationic Lipids for Transfection (2003)

Among other strategies, the use of cationic lipids as autoassembling vehicles for non viral DNA transfection has received considerable attention. An exponentially growing litterature has been published on this topic (over 700 hits for the past decade, including 400 in the last two years). The present review focuses on the main present strategies aiming at improving cationic lipids induced transfection, and on some of the frequently encountered problems that should be solved to apply these non-viral vectors for human health. The review contains several sections dealing with the chemistry, physico-chemistry, cell biology, in vivo biology, and targeting of cationic-lipid DNA complexes.