gebhart/patrepeval huggingface dataset:
Dynamic Virtual Network Connectivity Services to Support C-RAN Backhauling (2016)

Traditional distributed radio access networks (RANs) are evolving toward centralized architectures, with the aim of satisfying in a cost-effective manner the forecast traffic growth that future mobile networks will need to support. Specifically, the cloud RAN (C-RAN) architecture has shown that it can alleviate to some extent the ever-increasing total cost of ownership in mobile networks. The current trend in C-RAN is to separate remote radio heads with radio frequency (RF) functions and baseband unit (BBU) gathering baseband processing. This functional split allows the RF modules to be kept close to the antennas while placing BBUs at centralized locations so they can be shared among different sites and even be virtualized. However, some issues still need to be addressed in future mobile networks, especially due to the dynamicity of services and the strict constraints imposed by the interfaces needed. In fact, connectivity reconfiguration for X2 and S1 backhaul interfaces needs to be provided as an all-or-nothing request to enable mobile resource reconfiguration in a geographical area. In view of this, in this paper we propose dynamic customer virtual network (CVN) reconfiguration to be supported in metro and core network segments. Such CVN requests must include quality of service constraints to ensure specific delay constraints, as well as bitrate guarantees to avoid service interruption. A mathematical formulation and heuristic algorithm are presented for the CVN reconfiguration problem, and exhaustive simulation results study its performance in realistic scenarios.
Retrovirus-mediated gene transfer of tumor necrosis factor alpha into colon carcinoma cells generates a growth inhibition. (1993)

Retrovirus-mediated gene transfer was employed to introduce two different cDNAs of the human tumor necrosis factor alpha gene (TNF) into colon carcinoma cell lines either sensitive (LoVo) or resistant (LS174T) to the external addition of TNF. The TNF variants differed in their 5'-sequences (HTNF: authentic TNF cDNA, SPTNF: TNF cDNA with a signal sequence of the IgG heavy chain). The integration of TNF-specific DNA into the genomic DNA, the expression of TNF-specific mRNA and the translation into TNF protein was shown by Southern-, Northern- and Western analysis with TNF-specific DNA- and RNA probes and anti-TNF-antibodies, respectively. Neomycin selected tumor cell clones expressed biologically active TNF up to 40 pg/ml. As shown in a growth assay, both variants of TNF caused an up to 80% growth inhibition in colon carcinoma cells. Furthermore, the cells constitutively producing TNF had a distinguishable morphological appearance and a reduced colony growth in soft agar compared to the parental cells. The subcutaneous injection of 1 x 10(6) TNF-expressing tumor cells into nude mice resulted in a reduced tumor progression in comparison to the controls.
Peripheral Nerve Regeneration (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance (2004)

Two nonradioactive methods for determining glomerular filtration rate (GFR) in conscious mice using FITC-labeled inulin (FITC-inulin) were evaluated. The first method measured GFR using clearance kinetics of plasma FITC-inulin after a single bolus injection. Based on a two-compartment model, estimated GFR was 236.69 +/- 16.55 and 140.20 +/- 22.27 microl/min in male and female C57BL/6J mice, respectively. Total or (5/6) nephrectomy reduced inulin clearance to 0 or 32.80 +/- 9.32 microl/min, respectively. Conversely, diabetes mellitus induced by streptozotocin was associated with increased GFR. The other approach measured urinary inulin clearance using intraperitoneal microosmotic pumps to deliver FITC-inulin and metabolic cages to collect timed urine samples. This approach yielded similar GFR values of 211.11 +/- 26.56 and 157.36 +/- 20.02 microl/min in male and female mice, respectively. These studies demonstrate the feasibility of repeated nonisotopic measurement of inulin clearance in conscious mice.
Mutational Activation of the STE5 Gene Product Bypasses the Requirement for G Protein β and γ Subunits in the Yeast Pheromone Response Pathway (1994)

The STE5 gene encodes an essential element of the pheromone response pathway which is known to act either after the G subunit encoded by the STE4 gene or at the same step. Mutations in STE5, designated STE5Hyp, that partially activate the pathway in the absence of pheromone were isolated. One allele (STE5Hyp-2) was shown to cause a single amino acid substitution near the N terminus of the predicted STE5 protein. Immunoblotting with anti-Ste5 antibodies indicated that the phenotype was not due to an increased level of the mutant STE5 protein. A multicopy episomal plasmid containing a STE5Hyp allele partially suppressed both the block in pheromone-inducible transcription and the sterility phenotype caused by null alleles of the STE2, STE4, or STE18 gene, indicating that the STE5 product acts after the receptor (STE2 product) and after the G protein beta and gamma subunits (STE4 and STE18 products, respectively). However, the phenotypes of the STE5Hyp mutations were less pronounced in ste4 and ste18 mutants, suggesting that the STE5Hyp-generated signal partially depends on the proposed G beta gamma complex. The STE5Hyp alleles did not suppress ste7, ste11, ste12, or fus3 kss1 null mutants, consistent with previous findings that the STE5 product acts before the protein kinases encoded by STE7, STE11, FUS3, and KSS1 and the transcription factor encoded by STE12. The mating defects of the ste2 deletion mutant and the temperature-sensitive ste4-3 mutant were also suppressed by overexpression of wild-type STE5. The slow-growth phenotype manifested by cells carrying STE5Hyp alleles was enhanced by the sst2-1 mutation; this effect was eliminated in ste4 mutants. These results provide the first evidence that the STE5 gene product performs its function after the G protein subunits.
L3P40-50—a new lung-tumor-associated 40- to 50-kDa antigen defined by a monoclonal antibody (L3) (1994)

A monoclonal antibody (MAb), designated L3, was raised against a human-lung-adenocarcinoma-derived cell line, A549. Immunohistological studies showed reactivity of MAb L3 with 70 to 90% of lung tumors representing the 4 major histotypes. Strongest reactivity was seen with squamous-cell cancer and adenocarcinoma, with strong intracellular staining of the tumor cells. In small-cell lung cancer, staining was seen in a minority of tumor cells. Normal tissue staining was seen with thyroid follicular cells and focally with epithelial cells of the bronchi, the colon and the small intestine. Normal liver parenchyma was negative, whereas hepatocytes surrounding metastatic lesions were strongly stained. This pattern of staining was also seen for connective tissue. Western-blot analysis showed that the antigen defined by MAb L3 has an apparent molecular weight of 40 to 50 kDa, and hence is denominated L3p40-50. Our results suggest that L3p40-50 represents an undescribed tumor antigen.
Adaptive information rate performance on bandlimited meteor burst channels: empirical results (1990)

An investigation is conducted of the throughput performance of two adaptive information rate schemes on the bandlimited meteor-burst communications channel. The first technique, called adaptive symbol rate, uses a fixed waveform modulation and adapts the channel symbol rate to match the received signal-to-noise ratio. The second technique, called adaptive trellis-coded modulation (adaptive TCM), uses the familiar M-ary PSK (phase-shift-key) signal sets with TCM and varies the information rate by adapting the number of information bits per channel symbol to the channel conditions. Experimental data from the USAF High Latitude Greenland Test Bed are used to validate previously derived theoretical performance predictions. Theoretical predictions show that adaptive-symbol-rate improvement over conventional fixed-rate technique is bounded by a factor of 2 and that adaptive TCM improvement exceeds a factor of 3. Data from the Greenland Test Bed show close agreement with these theoretical predictions and confirm the superiority of adaptive TCM for bandlimited meteor-burst channels.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity. (1993)

SRY, a putative transcription factor encoded by the sex-determining region of the human Y chromosome, regulates a genetic switch in male development. Impairment of this switch leads to intersex abnormalities of the newborn and is observed in association with mutations in the SRY DNA-binding domain [the high-mobility-group (HMG) box]. Here we show that the SRY HMG box exhibits a novel mechanism of DNA recognition: partial intercalation of a nonpolar side chain in the DNA minor groove. Base stacking (but not base pairing) is interrupted at the site of insertion. Sequence specificity reflects topological requirements of partial intercalation rather than direct readout of base-specific functional groups. Our results predict that the SRY HMG box inserts an alpha-helix into a widened minor groove at the center of a sharp DNA bend. A similar mechanism may underlie binding of SRY and homologous HMG proteins to four-way junctions (Holliday intermediates) and other noncanonical DNA structures.
Tissue Factor: molecular recognition and cofactor function (1995)

One aspect of the inflammatory response is the activation of the coagulation protease cascade resulting from the expression of tissue factor (TF) on vascular cells. TF is the cell-surface receptor for the coagulation serine protease factor VIIa, providing cofactor function by "switching on" the catalytic site of the bound enzyme and by contributing to the assembly with macromolecular substrate. The recently determined crystal structure of the TF extracellular domain shows two beta-strand modules of C2 immunoglobulin-like topology that align at a 125 degrees angle with an extensive intermodule interface. Mutagenesis studies have identified residues in both modules that are important for the binding of ligand. The deduced ligand interface extends from the convex side of the molecule into the concave side of the elbow angle. Specific binding residues control the catalytic activity of the bound protease. At the lower end of the carboxyl-terminal module, basic residues form part of a region that is important for both recognition and activation of macromolecular substrate and, potentially, for modulation of proteolytic function. After combining the biochemical data with the crystal structure, a model of TF function can be proposed in which the catalytic activity of the active site of the protease and the extended recognition of macromolecular substrates are separately controlled by distinct structural sites of the cofactor.
Asymptotically Optimal Topological Quantum Compiling (2014)

We address the problem of compiling quantum operations into braid representations for non-Abelian quasiparticles described by the Fibonacci anyon model. We classify the single-qubit unitaries that can be represented exactly by Fibonacci anyon braids and use the classification to develop a probabilistically polynomial algorithm that approximates any given single-qubit unitary to a desired precision by an asymptotically depth-optimal braid pattern. We extend our algorithm in two directions: to produce braids that allow only single-strand movement, called weaves, and to produce depth-optimal approximations of two-qubit gates. Our compiled braid patterns have depths that are 20 to 1000 times shorter than those output by prior state-of-the-art methods, for precisions ranging between 10(-10) and 10(-30).
El Gnomologicum Vaticanum y la filosofía de Epicuro (2016)

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Filosofía y Letras, Departamento de Filosofía. Fecha de lectura: 27 de abril de 2016
N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats (1994)

NO is critical to the development of both the inflammatory and erosive components of adjuvant arthritis in rats. There may be a future clinical role for suitable inhibitors of NO production or activity.
Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis-associated pain: phase 2 safety and efficacy 24-week results (2021)

Treatment with relugolix for 24 weeks was generally well tolerated and demonstrated similar pain reduction to leuprorelin in women with endometriosis. The dose-dependent loss in BMD observed with relugolix treatment was expected due to an induced hypoestrogenic state. Relugolix demonstrated a similar benefit/risk profile to injectable therapy in this phase 2 study. Trial registration NCT01452685 (ClinicalTrials.gov, registered 17/10/2011).
Recognizing Words in Scenes with a Head-Mounted Eye-Tracker (2012)

Recognition of scene text using a hand-held camera is emerging as a hot topic of research. In this paper, we investigate the use of a head-mounted eye-tracker for scene text recognition. An eye-tracker detects the position of the user's gaze. Using gaze information of the user, we can provide the user with more information about his region/object of interest in a ubiquitous manner. Therefore, we can realize a service such as the user gazes at a certain word and soon obtain the related information of the word by combining a word recognition system with eye-tracking technology. Such a service is useful since the user has to do nothing but gazes at interested words. With a view to realize the service, we experimentally evaluate the effectiveness of using the eye-tracker for word recognition. The initial results show the recognition accuracy was around 70% in our word recognition experiment and the average computational time was less than one second per a query image.
Enzymology of Bacterial Lysine Biosynthesis (2012)

by succinyldiaminopimelate desuccinylase (SDAP-DS, EC 3.5.1.
Hyaluronic Acid and its Effect on Postoperative Adhesions in the Rabbit Flexor Tendon (1986)

The effect of hyaluronic acid in preventing adhesion formation in a surgically prepared rabbit flexor tendon model has been evaluated. Nineteen rabbits had partial tenotomy of the middle digit flexor profundus tendon, eight being treated with hyaluronic acid and eleven with saline. The quality of tendon repair and the quantity of adhesion tissue were graded. Though both the treated and control groups showed significant adhesions, the hyaluronic acid treated tendons showed less adhesion tissue and better sliding properties as compared to the controls. No significant difference was noted in the quality of tendon repair and no adverse effects of hyaluronic acid were seen. It is proposed that additional investigation into the development of a better model of postoperative tendon adhesions and an improved characterization of this model are needed. This preliminary study suggests that hyaluronic acid is effective in reducing the quantity of adhesions after tendon surgery but warrants further evaluation.
Inhibition of 5 alpha-reductase, receptor binding, and nuclear uptake of androgens in the prostate by a 4-methyl-4-aza-steroid. (1981)

17 beta-N,N-Diethylcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one (DMAA) is a potent reversible inhibitor of 5 alpha-reductase. The inhibition by DMAA of the conversion of testosterone to 5 alpha-dihydrotestosterone by rat prostate 5 alpha-reductase is competitive with testosterone, the apparent Ki being 5 nM, and uncompetitive with NADPH, DMAA inhibited both membrane-bound and solubilized 5 alpha-reductase. DMAA has moderate affinity for the prostate cytosol androgen receptor: 3 X 10(-6) M gives 50% inhibition of the binding of 10(-9) M 5 alpha-[3H]dihydrotestosterone to this receptor. This affinity to the androgen receptor is 1,000-, 500-, 120-, and 40-fold lower than that of 5 alpha-dihydrotestosterone, testosterone, spironolactone, and cyproterone acetate, respectively, and 7-fold higher than that of cimetidine. After incubation of [3H]testosterone with minced prostate, more than 90% of the radioactivity extracted from the nuclei co-chromatographed with 5 alpha-dihydrotestosterone and the rest with testosterone. DMAA at low concentrations decreased the ratio of 5 alpha-dihydrotestosterone to testosterone in the nuclei without significantly reducing the total uptake. DMAA at high concentrations also reduced the total radioactivity in the nuclei. This differential effect may reflect a higher affinity of DMAA for 5 alpha-reductase than for the androgen receptor. When 5 alpha-[3H]dihydrotestosterone was used in the tissue incubations, all radioactivity extracted from nuclei co-chromatographed with 5 alpha-dihydrotestosterone, regardless of whether or not DMAA was present. This nuclear uptake of 5 alpha-dihydrotestosterone is inhibited only by high concentrations of DMAA. In a cell-free system, the nuclear uptake of 5 alpha-[3H]dihydrotestosterone prebound to the cytosol receptor was not inhibited by DMAA. These results suggest that DMAA may inhibit nuclear uptake of 5 alpha-dihydrotestosterone by inhibiting the receptor binding. Sucrose gradient centrifugation of the radioactive KCl nuclear extracts prepared from the tissue incubations showed that the nuclear [3H]testosterone-receptor complex has a greater rate of dissociation than does the nuclear 5 alpha-[3H]dihydrotestosterone-receptor complex. [3H]Testosterone prebound to the prostate cytosol receptor also dissociates faster than 5 alpha-[3H]dihydrotestosterone prebound to the cytosol receptor.
Stimulation of 5‐HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats (1998)

This study investigated the effect of stimulating 5-HT1A receptors in the dorsal raphe on the impairment of learning caused by 4 microg/microL scopolamine injected in the CA1 region of the dorsal hippocampus in rats performing a two-platform spatial discrimination task. At 1 (but not 0.2) microg/0.5 microL administered in the dorsal raphe on each acquisition training day 5 min before bilateral intrahippocampal injection of 4 microg/microL scopolamine, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, had no effect on choice accuracy and latency or errors of omission but completely antagonized the impairment of choice accuracy by intrahippocampal scopolamine. Administered into the dorsal raphe at 0.2 and 1 microg/0.5 microL, WAY 100635, a 5-HT1A receptor antagonist, had no effect on rats' performance or on the impairment caused by intrahippocampal scopolamine but dose-dependently antagonized the effect of 1 microg/0.5 microL 8-OH-DPAT on the scopolamine-induced deficit. The results show that stimulation of presynaptic 5-HT1A receptors in the dorsal raphe reverses the deficit caused by intrahippocampal scopolamine, probably by facilitating the transfer of facilitatory information from the entorhinal cortex to the hippocampus. Together with a previous study showing that blockade of postsynaptic hippocampal 5-HT1A receptors antagonized the effect of intrahippocampal scopolamine in the two-platform spatial discrimination task (Carli et al., 1995b), the results suggest that drugs with presynaptic stimulatory and postsynaptic blocking actions on 5-HT1A receptors, such as partial agonists at these receptors, may be useful in the symptomatic treatment of human memory disturbances associated with loss of cholinergic innervation to the hippocampus.
Obeticholic Acid: A New Era in the Treatment of Nonalcoholic Fatty Liver Disease (2018)

The main treatments for patients with nonalcoholic fatty liver disease (NAFLD) are currently based on lifestyle changes, including ponderal decrease and dietary management. However, a subgroup of patients with nonalcoholic steatohepatitis (NASH), who are unable to modify their lifestyle successfully, may benefit from pharmaceutical support. Several drugs targeting pathogenic mechanisms of NAFLD have been evaluated in clinical trials for the treatment of NASH. Farnesoid X receptor (FXR) is a nuclear key regulator controlling several processes of the hepatic metabolism. NAFLD has been proven to be associated with abnormal FXR activity. Obeticholic acid (OCA) is a first-in-class selective FXR agonist with anticholestatic and hepato-protective properties. Currently, OCA is registered for the treatment of primary biliary cholangitis. However, promising effects of OCA on NASH and its metabolic features have been reported in several studies.
Growth of Natural Yeast Flora during the Fermentation of Inoculated Wines (1985)

The growth of yeasts that occur naturally in grape juice was quantitatively examined during the fermentation of four wines that had been inoculated with Saccharomyces cerevisiae. Although S. cerevisiae dominated the wine fermentations, there was significant growth of the natural species Kloeckera apiculata, Candida stellata, Candida colliculosa, Candida pulcherrima, and Hansenula anomala.
Two-year double-blind trial of a monomethoxy polyethylene glycol (mPEG) modified grass pollen extract at different dose levels. (1992)

The aim of this study was to compare the efficacy and safety of a monomethoxypolyethylene glycol (mPEG) modified grass pollen mix allergen preparation (mPEG-gm) and a partly purified grass pollen mix allergen preparation (gm) in hyposensitization (HS), evaluating both products at two dose levels. Thirty adult patients with allergic rhinoconjunctivitis were allocated into two treatment groups based on their sensitivity to conjunctival provocation tests (CPT). Treatment was given in a double-blind manner. The starting dose was 20 BU and was approximately doubled weekly up to 20,000 BU the first year and 120,000 BU the second year. Skin testing and CPT were performed before treatment and at each dose level. All patients reached 20,000 BU the first year. Twenty-five patients continued the second year. Twenty-one of those reached 120,000 BU (9/12 on mPEG-gm and 12/13 on gm). The frequency of general side effects was reduced by about 50% with the mPEG grass mix compared with native grass mix. A significant improvement in the conjunctival sensitivity was found in both treatment groups the second year (120,000 BU) but not the first year (20,000 BU). Seventy-eight percent of the patients in the gm group and 50% in the mPEG-gm group improved by CPT (not statistically significant). The skin sensitivity was reduced after 1 year at low dose in 69% of the gm-treated patients and 33% of the mPEG treated patients. After the second year at high dose levels, the skin sensitivity decreased in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Quality of life and stimulation of weight gain after treatment with megestrol acetate: correlation between cytokine levels and nutritional status, appetite in geriatric patients with wasting syndrome. (2000)

In a geriatric nursing home population with weight loss, reduction in cytokine levels after MA treatment correlates with improvement in appetite, prealbumin, albumin, and improvement in quality of life.