gebhart/patrepeval huggingface dataset:
Preparation of Nanostructured Microporous Metal Foams through Flow Induced Electroless Deposition (2015)

Monolithic nanostructured metallic porous structures with a hierarchy of pore size ranging from ca. 10 μ m to 1 nm are processed for use as microreactors. The technique is based on flow induced electroless deposition of metals on a porous template known as PolyHIPE Polymer. The process is conducted in a purpose built flow reactor using a processing protocol to allow uniform and efficient metal deposition under flow. Nickel chloride and sodium hypophosphite were used as the metal and reducing agent, respectively. Electroless deposition occurs in the form of grains with a composition of Ni x P y in which the grain size range was ca. 20–0.2 μ m depending on the composition of the metal deposition solution. Structure formation in the monoliths starts with heat treatment above 600°C resulting in the formation of a 3‐dimensional network of capillary‐like porous structures which form the walls of large arterial pores. These monoliths have a dense but porous surface providing mechanical strength for the monolith. The porous capillary‐like arterial pore walls provide a large surface area for any catalytic activity. The mechanisms of metal deposition and nanostructure formation are evaluated using scanning electron microscopy, energy dispersive X‐ray analysis, XRD, BET‐surface area, and mercury intrusion porosimetry.
Evaluation of jet nebulisers for use with gentamicin solution. (1985)

Recently nebulised antibiotics (gentamicin and carbenicillin) have been used successfully to treat respiratory tract infection in patients with cystic fibrosis. No information exists, however, on the choice of nebuliser or the ideal mode of operation with antibiotic solutions, which are often viscous. The aerosol output, droplet size, and nebulisation time were assessed for four common brands of jet nebuliser (Bird, DeVilbiss, Inspiron, and Upmist) used to nebulise 2 ml (80 mg) and 4 ml (160 mg) of gentamicin solution (Garamycin, Kirby-Warrick) at four compressed gas flow rates (6, 8, 10, and 12 1 . min-1). There were considerable variations between the nebulisers, DeVilbiss and Upmist being most efficient in the release of respirable (less than 5 micron diameter) droplets. Droplet size and nebulisation time were inversely proportional to gas flow rate. Aerosol output and nebulisation time were increased by raising the volume fill from 2 to 4 ml, although nebulisation time could still be restricted to 12 minutes or less with DeVilbiss and Upmist at 12 1 . min-1. The output of drug in droplets of below 5 micron diameter ranged from 7.2 (SE 0.4) to 71.4 (4.3) mg, according to the type of nebuliser, flow rate, and volume fill. These studies suggest that for optimal drug delivery 4 ml gentamicin solution should be nebulised either at a fixed flow rate of 10-12 1 . min-1 or with a high flow compressor. Previous unsatisfactory clinical results with antibiotic aerosols may have been due in part to incorrect choice of nebuliser or inappropriate operating conditions, or both.
The Piecewise Data Flow Architecture: Architectural Concepts (1983)

This paper presents the design and a brief analysis of the Piecewise Data Flow computer (PDF), an architecture proposed for very high-performance computing. PDF is a heterogeneous multiprocessor system having both SIMD and MIMD characteristics. Each computation is translated into a control flow graph in which each node contains a basic block of instructions. Concurrency can be exploited in three different ways: simultaneous execution of independent basic blocks, simultaneous execution of independent instructions within a basic block, and intrinsic array operations. This program representation is amenable to traditional languages (e.g., Fortran) because almost all optimizing compilers use basic blocks as their internal representation. New functional languages should be able to exploit this architecture even more easily. The most significant aspects of the PDF architecture concern scheduling basic blocks for execution, allocating registers to intermediate results, and assigning instructions to processors.
Transient receptor potential ion channels as participants in thermosensation and thermoregulation (2006)

Living organisms must evaluate changes in environmental and internal temperatures to mount appropriate physiological and behavioral responses conducive to survival. Classical physiology has provided a wealth of information regarding the specialization of thermosensory functions among subclasses of peripheral sensory neurons and intrinsically thermosensitive neurons within the hypothalamus. However, until recently, the molecular mechanisms by which these cells carry out thermometry have remained poorly understood. The demonstration that certain ion channels of the transient receptor potential (TRP) family can be activated by increases or decreases in ambient temperature, along with the recognition of their heterogeneous expression patterns and heterogeneous temperature sensitivities, has led investigators to evaluate these proteins as candidate endogenous thermosensors. Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. In contrast, although capsaicin-sensitive mechanisms clearly influence core body temperature regulation, the specific contribution of TRPV1 to this process remains a matter of debate. Besides TRPV1, at least six additional thermally sensitive TRP channels have been identified in mammals, and many of these also appear to participate in thermosensation. Moreover, the identification of invertebrate TRP channels, whose genetic ablation alters thermally driven behaviors, makes it clear that thermosensation represents an evolutionarily conserved role of this ion channel family.
Energy and Energy Cost Savings Analysis of the IECC for Commercial Buildings (2013)

The purpose of this analysis is to assess the relative energy and energy cost performance of commercial buildings designed to meet the requirements found in the commercial energy-efficiency provisions of the International Energy Conservation Code (IECC). Section 304(b) of the Energy Conservation and Production Act (ECPA), as amended, requires the Secretary of Energy to make a determination each time a revised version of ASHRAE Standard 90.1 is published with respect to whether the revised standard would improve energy efficiency in commercial buildings. As many states have historically adopted the IECC for both residential and commercial buildings, PNNL has evaluated the impacts of the commercial provisions of the 2006, 2009, and 2012 editions of the IECC. PNNL also compared energy performance with corresponding editions of ANSI/ASHRAE/IES Standard 90.1 to help states and local jurisdictions make informed decisions regarding model code adoption.
Atomic Layer Deposition of High Dielectric Constant Nanolaminates (2001)

Thin stacks comprised of alternating layers of and were investigated as high-permittivity insulators for possible gate dielectric applications. These thin layers were deposited on silicon substrates using atomic layer deposition. Nanolaminates with silicon oxide equivalent thickness of about 2 nm had dielectric constants of around ten and leakage current densities at 1 MV/cm of around Of the three kinds of nanolaminates investigated, structures showed the highest breakdown field and the lowest leakage current. © 2001 The Electrochemical Society. All rights reserved.
Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts. (1988)

The specific uptake of 125I-A6H antibody by xenografts of the human renal cell carcinoma (RCC) TK177G in the athymic mouse was considerably greater than that seen for other human tumor xenografts and their associated antibodies (e.g., 125I-B6.2 uptake by the human breast carcinoma, Clouser). In addition the A6H-RCC model also demonstrated both greater localization indices and absolute amount of antibody bound than did the B6.2-Clouser model. Several physiological factors were studied to assess whether they might play a role in this greater specific uptake. Vascular volume was determined using the in situ labeling of red blood cells with 99mTc. Vascular permeability was determined by measuring the amount of 125I-labeled bovine serum albumin and 131I-labeled nonspecific IgG1 (anti-horseradish peroxidase) extravasated out of the tumor vasculature during 1 hr. Relative blood flow to the tumor was determined using the 86Rb method. Blood flow and vascular permeability were found to be significantly greater in the RCC tumor xenografts than in Clouser tumors. Differences in vascular permeability were especially dramatic, showing the vasculature of the RCC xenograft was twice as permeable as that of the Clouser tumor. Animals bearing either RCC or Clouser xenografts were injected with a monoclonal antibody to human major histocompatibility complexes (125I-labeled anti-human histocompatibility complex A, B, C). Tumor uptake of 125I-labeled anti-human histocompatibility complex A, B, C was found to be 5 times greater in RCC than Clouser xenografts. These results, therefore, suggest that the differences seen in the physiological factors studied can account for some of the greater specific 125I-A6H uptake by the RCC tumor than 125I-B6.2 uptake by the Clouser xenograft.
Toys communicating with LEDs: Enabling toy cars interaction (2012)

Communication capabilities are becoming a popular feature for premium smart toys. However, the higher cost of such transmitters are limiting the widespread use to all consumer users. In this contribution, we demonstrate a cost-effective toy communication using LED-based visible light communication (VLC), where messages sent via VLC are i) displayed on a screen, or ii) passed from one node (like a car) to another in a multi-hop way.
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line (1999)

An estimated 170 million persons worldwide are infected with hepatitis C virus (HCV), a major cause of chronic liver disease. Despite increasing knowledge of genome structure and individual viral proteins, studies on virus replication and pathogenesis have been hampered by the lack of reliable and efficient cell culture systems. A full-length consensus genome was cloned from viral RNA isolated from an infected human liver and used to construct subgenomic selectable replicons. Upon transfection into a human hepatoma cell line, these RNAs were found to replicate to high levels, permitting metabolic radiolabeling of viral RNA and proteins. This work defines the structure of HCV replicons functional in cell culture and provides the basis for a long-sought cellular system that should allow detailed molecular studies of HCV and the development of antiviral drugs.
Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes (2008)

The generality of molecular signatures for environmental adaptation of extreme salt-loving organisms, demonstrated in the present study, advocates the convergent evolution of halophilic species towards specific genome and amino acid composition, irrespective of their varying GC-bias and widely disparate taxonomic positions. The adapted features of halophiles seem to be related to physical principles governing DNA and protein stability, in response to the extreme environmental conditions under which they thrive.
Automatic sizing of power/ground (P/G) networks in VLSI (1989)

This paper presents a fast and efficient method for sizing power/ground networks. No restrictions on network topology or number of supplying pads are imposed. Wire widths are calculated such that the weighted area of wire segments is minimized while electromigration and voltage drops constraints are fulfilled. The algorithm proposed here runs 50% faster than the best methods reported for tree type network topologies.
Application of ultraviolet depth lithography for surface micromachining (1995)

Very thick photoresist layers were patterned by contact ultraviolet (UV) lithography. In a following microelectrodeposition step the generated resist patterns were molded and three-dimensional (3D) microstructures were fabricated directly onto system surfaces. The new technology, called 3D UV-microforming, consists of an advanced resist preparation process, an UV lithographic step, resist development, a molding procedure by electrodeposition, and finally stripping and cleaning for finishing the structures. It enables the low-cost fabrication of a wide variety of microcomponents for many different uses. During resist preparation, layers up to 200 μm thickness were obtained. By using a standard UV mask aligner as an exposure tool followed by immersion development, thick resist layers up to 100 μm could be patterned in a single step on preprocessed silicon wafers. Repeated exposure and development were successfully used for structuring resist layers of up to 200 μm thickness. Using AZ 4000 series photoresist, the resolution is also limited by mechanical stability. For lines and spaces in 15-μm-thick resist a minimum width of 3 μm for the resist was found to be necessary to overcome the fabrication process. For thicker layers high aspect ratios of more than 10 as well as steep edges of more than 88° could be fabricated. The resist patterns used were molded by pulse or by direct current electroplating. For microsystem applications some metals and alloys were deposited. Three-dimensional microcomponents were fabricated as samples for demonstrating the new technique. The technique allows the use of materials with interesting properties, ones that could not be provided by standard processes.
Survivin expression is significantly higher in pN+ oral and oropharyngeal primary squamous cell carcinomas than in pN0 carcinomas (2005)

Sporadic groups of normal basal and parabasal epithelial cells showed weak survivin staining. In SCCs, a nuclear reaction predominated. Eight primary pN+ SCCs were survivin-positive (mean expression 34.7%), compared to 5 primary pN0 SCCs (mean expression 12.3%; p=0.017). Statistical analysis disclosed significantly higher survivin expression in primary oral and oropharyngeal SCCs that developed distant non-lymphatic metastases (p=0.012).
Influence of Resin Monomers on Growth of Oral Streptococci (2004)

Ethyleneglycol dimethacrylate monomers have been previously reported to stimulate the growth of certain caries-associated bacteria on the basis of turbidity measurements. To elucidate the detail of this effect, we examined the influence of resin monomers on the growth of Streptococcus sobrinus and Streptococcus sanguis by determination of bacterial numbers (colony-forming units), morphological observation, and chemical analysis. Although the absorbance values in the stationary phase of bacterial suspension were increased in the presence of ethyleneglycol monomers, no significant differences were observed for bacterial numbers throughout the incubation period. Scanning electron microscopy observation revealed the formation of sparse vesicular material surrounding bacterial cells when incubated with ethyleneglycol monomers, and these products were proved to be resin polymers. The results demonstrate that the apparent biomass increase during incubation with ethyleneglycol monomers is due not to promotion of bacterial multiplication, but to the polymerization of resin monomers to form vesicular structures attached to cells.
Cell-Based Tissue-Engineered Allogeneic Implant for Cartilage Repair (2000)

The potential for using of allogeneic cartilage chips, transplanted in a biologic polymer with articular chondrocytes, as a tool for articular cartilage repair was studied. Small lyophilized articular cartilage chips were mixed with a cell/fibrinogen solution and thrombin to obtain implantable constructs made of fibrin glue, chondrocytes, and cartilage chips. Specimens were implanted in the subcutaneous tissue on the backs of nude mice (experimental group A). Three groups of controls (groups B, C, and D) were also prepared. Group B consisted of fibrin glue and cartilage chips without chondrocytes. Group C consisted of fibrin glue and chondrocytes without cartilage chips, and group D was composed solely of fibrin glue. All samples were carefully weighed before implantation in the mice. The constructs were harvested from the animals at 6, 9, and 12 weeks, examined grossly, and weighed. The samples were then processed and stained with hematoxylin and eosin for histological examination. Gross evaluation and weight analysis of the constructs at the time of retrieval showed retention of the original mass in the samples made of fibrin glue, chondrocytes, and cartilage chips (group A) and demonstrated a cartilaginous consistency upon probing. Specimens from constructs of fibrin glue and cartilage chips without chondrocytes (control group B) retained most of their volume, but were statistically lighter than specimens from group A and were much softer and more pliable than those in group A. Samples of specimens from constructs of fibrin glue and chondrocytes (groups C) and fibrin glue alone (group D) both showed a substantial reduction of their original masses over the experimental time periods when compared to the samples in groups A and B, although specimens from group C demonstrated new cartilage matrix formation. Histological analysis of specimens in experimental group A demonstrated the presence of cartilage chips surrounded by newly formed cartilaginous matrix, while specimens of control group B showed only fibrotic tissue surrounding the devitalized cartilage pieces. Cartilaginous matrix was also observed in control group C, in which cartilage chips were absent, whereas only fibrin glue debris was observed in control group D. This study demonstrated that a composite of fibrin glue and devitalized cartilage can serve as a scaffold for chondrocyte transplantation, preserve the original phenotype of the chondrocytes, and maintain the original mass of the implant. This may represent a valid option for addressing the problem of articular cartilage repair.
Keldysh theory of strong-field ionization (2010)

In this paper, we provide a detailed derivation of the strong-field ionization rates originally developed by Keldysh who introduced the strong-field approximation. Numerical results are presented to examine the saddle-point approximation, the low photoelectron energy approximation, and neglecting the interference terms, which are necessary to arrive at the simple quasistatic result, when the Keldysh parameter becomes very small.
A gene for late-onset fundus flavimaculatus with macular dystrophy maps to chromosome 1p13. (1995)

Fundus flavimaculatus with macular dystrophy is an autosomal recessive disease responsible for a progressive loss of visual acuity in adulthood, with pigmentary changes of the macula, perimacular flecks, and atrophy of the retinal pigmentary epithelium. Since this condition shares several clinical features with Stargardt disease, which has been mapped to chromosome 1p21-p13, we tested the disease for linkage to chromosome 1p. We report here the mapping of the disease locus to chromosome 1p13-p21, in the genetic interval defined by loci D1S435 and D1S415, in four multiplex families (maximum lod score 4.79 at recombination fraction 0 for probe AFM217zb2 at locus D1S435). Thus, despite differences in the age at onset, clinical course, and severity, fundus flavimaculatus with macular dystrophy and Stargardt disease are probably allelic disorders. This result supports the view that allelic mutations produce a continuum of macular dystrophies, with onset in early childhood to late adulthood.
Manipulation of music for melody matching (1998)

Many types of user would find it valuable to search collections of music via queries representing music fragments, but such searching requires a reliable technique for identifying whether a provided fragment occurs within a piece of music. The problem of matching fragments to music is made difficult by the psychology of music perception, because literal matching may have litile relation to perceived melodic similarity, and by the interactions between the multiple parts of typical pieces of music. In this paper we analyse the propeties of music, music perception, and music database users, and use the analysis to propose alternative techniques for extracting monophonic melodies from polyphonic music; we believe that such melodies can subsequently be used for matching of queries to data. We report on experiments with music listeners, which rank our proposed techniques for extracting melodies.
3D printed microfluidic devices with integrated valves (2015)

We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations.
Evaluation of Generalized Born Models for Large Scale Affinity Prediction of Cyclodextrin Host–Guest Complexes (2016)

Binding affinity prediction with implicit solvent models remains a challenge in virtual screening for drug discovery. In order to assess the predictive power of implicit solvent models in docking techniques with Amber scoring, three generalized Born models (GB<sup>HCT</sup>, GB<sup>OBC</sup>I, and GB<sup>OBC</sup>II) available in Dock 6.7 were utilized, for determining the binding affinity of a large set of β-cyclodextrin complexes with 75 neutral guest molecules. The results were compared to potential of mean force (PMF) free energy calculations with four GB models (GB<sup>Still</sup>, GB<sup>HCT</sup>, GB<sup>OBC</sup>I, and GB<sup>OBC</sup>II) and to experimental data. Docking results yield similar accuracy to the computationally demanding PMF method with umbrella sampling. Neither docking nor PMF calculations reproduce the experimental binding affinities, however, as indicated by a small Spearman rank order coefficient (∼0.5). The binding energies obtained from GB models were decomposed further into individual contributions of the binding partners and solvent environments and compared to explicit solvent simulations for five complexes allowing for rationalizing the difference between explicit and implicit solvent models. An important observation is that the explicit solvent screens the interaction between host and guest much stronger than GB models. In contrast, the screening in GB models is too strong in solutes, leading to overestimation of short-range interactions and too strong binding. It is difficult to envision a way of overcoming these two opposite effects.