gebhart/patrepeval huggingface dataset:
A novel treatment approach for paediatric Gorham–Stout syndrome with chylothorax (2011)

Abstract Aim: To expand the treatment options in paediatric Gorham–Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon‐α‐2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for &gt;2 years. Conclusion: The successful addition of a low anticoagulant, low molecular weight heparin (tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.
PET of Tumor CXCR4 Expression with 4-18F-T140 (2010)

4-(18)F-T140 can be used as a PET tracer to image tumor expression of CXCR4, with a high tumor-to-background ratio. The knowledge of whether tumors express or do not express CXCR4 might be beneficial in determining appropriate treatment and monitoring.
Equivalent capacity and its application to bandwidth allocation in high-speed networks (1991)

The authors propose a computationally simple approximate expression for the equivalent capacity or bandwidth requirement of both individual and multiplexed connections, based on their statistical characteristics and the desired grade-of-service (GOS). The purpose of such an expression is to provide a unified metric to represent the effective bandwidth used by connections and the corresponding effective load of network links. These link metrics can then be used for efficient bandwidth management, routing, and call control procedures aimed at optimizing network usage. While the methodology proposed can provide an exact approach to the computation of the equivalent capacity, the associated complexity makes it infeasible for real-time network traffic control applications. Hence, an approximation is required. The validity of the approximation developed is verified by comparison to both exact computations and simulation results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
RESISTANCE OF SOLID SURFACES TO WETTING BY WATER (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRESISTANCE OF SOLID SURFACES TO WETTING BY WATERRobert N. WenzelCite this: Ind. Eng. Chem. 1936, 28, 8, 988–994Publication Date (Print):August 1, 1936Publication History Published online1 May 2002Published inissue 1 August 1936https://pubs.acs.org/doi/10.1021/ie50320a024https://doi.org/10.1021/ie50320a024research-articleACS PublicationsRequest reuse permissionsArticle Views32431Altmetric-Citations10610LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Anti-Müllerian hormone: estimation of molecular weight by gel filtration. (1976)

Incubation medium of calf fetal testes was submitted to gel filtration on Sephades G 200 and Bio-Gel A-5 M, IN ORDER TO DETERMINE THE MOLECULAR WEIGHT OF THE ANTIMULLERIAN HORmone (A.M.H.) RESPONSIBLE FOR THE REGRESSION OF MULLERIAN DUCTS IN MALE FETUSES. Results from both series of experiments indicate a molecular weight in the range between 200,000 and 295,000 daltons, even in the presence of high concentration of a reducing agent.
Distributed logging for transaction processing (1987)

Increased interest in using workstations and small processors for distributed transaction processing raises the question of how to implement the logs needed for transaction recovery. Although logs can be implemented with data written to duplexed disks on each processing node, this paper argues there are advantages if log data is written to multiple log server nodes. A simple analysis of expected logging loads leads to the conclusion that a high performance, microprocessor based processing node can support a log server if it uses efficient communication protocols and low latency, non volatile storage to buffer log data. The buffer is needed to reduce the processing time per log record and to increase throughput to the logging disk. An interface to the log servers using simple, robust, and efficient protocols is presented. Also described are the disk data structures that the log servers use. This paper concludes with a brief discussion of remaining design issues, the status of a prototype implementation, and plans for its completion.
Insects as models to study the epigenetic basis of disease (2015)

Epigenetic inheritance refers to changes in gene expression that are heritable across generations but are not caused by changes in the DNA sequence. Many environmental factors are now known to cause epigenetic changes, including the presence of pathogens, parasites, harmful chemicals and other stress factors. There is increasing evidence that transcriptional reprogramming caused by epigenetic modifications can be passed from parents to offspring. Indeed, diseases such as cancer can occur in the offspring due to epigenetically-inherited gene expression profiles induced by stress experienced by the parent. Empirical studies to investigate the role of epigenetics in trans-generational gene regulation and disease require appropriate model organisms. In this review, we argue that selected insects can be used as models for human diseases with an epigenetic component because the underlying molecular mechanisms (DNA methylation, histone acetylation and the expression of microRNAs) are evolutionarily conserved. Insects offer a number of advantages over mammalian models including ethical acceptability, short generation times and the potential to investigate complex interacting parameters such as fecundity, longevity, gender ratio, and resistance to pathogens, parasites and environmental stress.
Role of CD4+and CD8+T Cells in Clearance of Primary Pulmonary Infection withCoxiella burnetii (2010)

The mechanisms of the primary adaptive immune response to Coxiella burnetii are not well known. Following inoculation of the lungs with C. burnetii Nine Mile phase I (NMI), SCID mice developed pneumonia and splenomegaly and succumbed to infection, whereas wild-type mice cleared the infection by 24 days. SCID mice reconstituted with either CD4+ T cells or CD8+ T cells alone were able to control the infection, indicating that the presence of either type of T cells was sufficient to control infection, and B cells were not necessary for primary immunity. Similarly, wild-type mice depleted of either CD4+ T cells or CD8+ T cells controlled infections in their lungs, but these mice were highly susceptible if they were depleted of both types of T cells. However, compared to CD4+ T-cell-dependent protection, CD8+ T-cell-dependent protection resulted in less inflammation in the lungs and less growth of bacteria in the spleens.
Procedure for preparing solution-cast perfluorosulfonate ionomer films and membranes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProcedure for preparing solution-cast perfluorosulfonate ionomer films and membranesRobert B. Moore and Charles R. MartinCite this: Anal. Chem. 1986, 58, 12, 2569–2570Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/ac00125a046https://doi.org/10.1021/ac00125a046research-articleACS PublicationsRequest reuse permissionsArticle Views1532Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pulse wave analysis and arterial stiffness. (1998)

Assessment of the pulse character is one of the earliest recorded medical skills, but objective recordings of the pulse waveform--sphygmography--emerged only in the nineteenth century. This technique fell into disuse with the advent of the sphygmomanometer, but interest has recently been rekindled with the introduction of computer technology and applanation tonometry. Pulse wave analysis (PWA) is a technique that allows the accurate recording of peripheral pressure waveforms and generation of the corresponding central waveform, from which the augmentation index and central pressure can be derived. In clinical studies, we have shown that PWA is a highly reproducible technique and easy to apply. Together with ECG-gated assessment of pulse wave velocity, also using PWA, these measures provide important information about arterial stiffness. Stiffness may be partly under the functional control of the endothelium, which releases a number of vasoactive mediators, as well as being structurally determined. Increased stiffness is associated with most cardiovascular risk factors and established atherosclerosis. However, increased stiffness may be more than a marker for occult atheroma. It may be involved in the pathogenesis of cardiovascular disease by a number of mechanisms. Assessment of stiffness, perhaps using PWA, may therefore provide better risk assessment and allow treatment to be targeted to those most in need.
Growth regulation of human renal carcinoma cells: role of transforming growth factor alpha. (1992)

Findings of increased numbers of epidermal growth factor receptors (EGF-R) and increased expression of transforming growth factor alpha (TGF-alpha) in surgical specimens of human renal cell carcinoma have led to the proposal that growth of these tumors may be regulated by TGF-alpha in an autocrine manner. In the studies presented here, we have examined this hypothesis using two human renal carcinoma cell lines, SKRC-4 and SKRC-29. We demonstrated that both SKRC-4 and SKRC-29 cells were growth stimulated by greater than 35% when cultured in the presence of TGF-alpha or EGF and were inhibited by 29% to 46% if cultured in the presence of anti-EGF-R monoclonal antibody 225. Treatment of cells with TGF-alpha enhanced the levels of expression of EGF-R mRNA and TGF-alpha mRNA. In addition, incubation of cells with monoclonal antibody 225 significantly elevated the levels of excreted TGF-alpha species in the culture medium. Our findings suggest that proliferation of human renal carcinoma cells may be regulated by endogenously produced TGF-alpha and that this regulatory pathway can be interrupted using antibody to its receptor, EGF-R.
Rotenone, Paraquat, and Parkinson’s Disease (2011)

PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.
TRANSPLANTED HUMAN AMNIOTIC EPITHELIAL CELLS EXPRESS CONNEXIN 26 AND NA-K-ADENOSINE TRIPHOSPHATASE IN THE INNER EAR (2004)

Cochlear fibrocytes are the crucial component of the inner ear homeostasis and its defect by various causes; GJB2 (connexin [Cx] 26) mutation, for example, leads to hearing loss. In the present study, we investigated the potential use of human amniotic epithelial cells, proposed to possess pluripotential properties, as a source of transplantation therapy in inner ear disease. The mRNA of the gap junction protein Cx26 and Na-K-adenosine triphosphatase, the immunohistologic expression of these proteins, and the cells' intercellular communication capacity were detected in vitro. Their transplantation into the guinea pig cochlea revealed the survival and expression of the proteins even 3 weeks after transplantation. Transplanted human amniotic epithelial cells were localized at the site where the proteins function, strongly indicating their cooperation in the regional potassium ion recycling. This technology suggests the therapeutic potential for the treatment of hearing loss.
Intensely Potent Doxorubicin Analogues:  Structure−Activity Relationship (1998)

N-(5,5-Diacetoxypent-1-yl)doxorubicin (1b) is an intensely cytotoxic doxorubicin analogue that retains full potency against tumor cells that express elevated levels of P-glycoprotein and are resistant to doxorubicin. 1b was designed to be hydrolyzed in the presence of carboxylate esterases to N-(5-oxypent-1-yl)doxorubicin, an aldehyde capable of existing in equilibrium with a cyclic carbinolamine. To investigate the structural determinants of potency for 1b, we have prepared a series of chemically related compounds in which various omega-[bis(acetoxy)]alkyl or omega-[bis(acetoxy)]alkoxyalkyl groups are substituted at the 3'-amino position of the daunosamine sugar. These groups were selected to assess the effect of chain length, oxygen substitution, and carbinolamine ring size on analogue potency. The compounds were evaluated for their ability to inhibit the in vitro growth of the following cell lines: (a) Chinese hamster ovary (CHO) cells, (b) a CHO cell mutant 100-fold resistant to doxorubicin that expresses elevated levels of P-glycoprotein, (c) a murine ductal cell pancreatic adenocarcinoma (Panc 02), and (d) a murine mammary carcinoma (CA 755). The most potent members of the series were those that could form a straight chain aldehyde intermediate after esterase-mediated hydrolysis of the omega-bis(acetoxy) groups and give rise to 5- or 6-membered ring carbinolamines. Analogues capable of forming 7-, 8-, or 9-membered carbinolamines were markedly less active. The N-methyl derivative of 1b, which cannot give rise to a cyclic carbinolamine, was 2 orders of magnitude less potent than 1b. A branched chain analogue, 1f, which contained a tertiary carbon atom adjacent to the omega-bis(acetoxy) groups, was also substantially less active than its nonbranched counterpart, 1a. These findings suggest that the chain length of the 3'-amino substituents and the ability of the derived aldehydes to form 5- or 6-membered carbinolamines are critical determinants of biologic potency.
<title>Electroelastomers: applications of dielectric elastomer transducers for actuation, generation, and smart structures</title> (2002)

Electroactive polymers (EAPs) can overcome many limitations of traditional smart material and transducer technologies. A particularly promising class of EAP is dielectric elastomer, also known as electroelastomer. Dielectric elastomer transducers are rubbery polymer materials with compliant electrodes that have a large electromechanical response to an applied electric field. The technology has been developed to the point where exceptional performance has already been demonstrated: for example, actuated strains of over 300 percent. These strains and the corresponding energy densities are beyond those of other field-activated materials including piezoelectrics. Because of their unique characteristics and expected low cost, dielectric elastomer transducers are under development in a wide range of applications including multifunctional (combined actuation, structure, and sensing) muscle-like actuators for biomimetic robots; microelectromechanical systems (MEMS); smart skins; conformal loudspeakers; haptic displays; and replacements for electromagnetic and pneumatic actuators for industrial and commercial applications. Dielectric elastomers have shown unique performance in each of these applications; however, some further development is required before they can be integrated into products and smart-materials systems. Among the many issues that may ultimately determine the success or failure of the technology for specific applications are durability, operating voltage and power requirements, and the size, cost, and complexity of the required electronic driving circuitry.
Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women (2003)

Estrogen plus progestin increases the risk of ischemic stroke in generally healthy postmenopausal women. Excess risk for all strokes attributed to estrogen plus progestin appeared to be present in all subgroups of women examined.
Blood pressure and high blood pressure. Aspects of risk. (1991)

This report deals with three aspects of risk related to blood pressure and high blood pressure. The first aspect of risk concerns distributions of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the adult population and their relation to long-term risk of morbidity and mortality. By middle age, only a minority (about 20%) of Americans have optimal SBP and DBP levels, less than 120 mm Hg and less than 80 mm Hg, respectively. For the majority with higher levels, risks of major clinical events, including death from cardiovascular diseases and from all causes, are markedly increased. The relations of SBP and DBP with risk are strong, continuous, and graded. Risk is sizable not only for persons with high blood pressure by usual clinical criteria (SBP greater than or equal to 140 mm Hg or DBP greater than or equal to 90 mm Hg), but also for those with "high-normal" blood pressure (e.g., SBP 130-139 mm Hg or DBP 80-89 mm Hg). Thus, the blood pressure problem is a population-wide one and requires for its control a combined population-wide and high-risk strategy. A major component of this strategy must be nutritional-hygienic measures for the primary prevention of the rise in blood pressure during adulthood and of high blood pressure (i.e., primary prevention not only of the complications of high blood pressure but also of high blood pressure itself) through improved lifestyles having the potential to shift downward the blood pressure distribution of the whole population. The second aspect of risk concerns the known risk factors (i.e., aspects of modern lifestyle) leading to the mass occurrence of blood pressure rise during adulthood and of high blood pressure. These risk factors are high salt intake, high dietary sodium/potassium ratio, calorie imbalance and resultant obesity, and high alcohol intake. The extensive data base establishing the role of these common traits in the etiology of the blood pressure/high blood pressure problem is the scientific foundation for efforts to achieve the primary prevention of high blood pressure. The third aspect of risk relates to the combined impact of other risk factors along with blood pressure-high blood pressure in markedly increasing the probabilities of morbidity and mortality (e.g., "rich" diet, diet-dependent serum cholesterol and uric acid, smoking, diabetes, and target-organ damage). Prevention and control of lifestyle-related traits are essential components of the strategy for dealing with the blood pressure-high blood pressure problem.
Induction of Apoptosis by Xanthones from Mangosteen in Human Leukemia Cell Lines (2003)

We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
Truncated peptides from melittin and its analog with high lytic activity at endosomal pH enhance branched polyethylenimine‐mediated gene transfection (2012)

The results obtained in the present study indicate that the truncated peptides with higher endosomal disrupting activity were better enhancers for increasing transfection efficiency.
On Overview of the Andrew File System. (1988)

CMU-ITC-88-062 Andrew is a distributed computing environment being developed in a joint project by Carnegie Mellon University and IBM. One of the major components of Andrew is a distributed file system. The goal of the Andrew File System is to support growth up to at least 7000 workstations (one for each student, faculty member, and staff at Carnegie Mellon) while providing users, application programs, and system administrators with the amenities of a shared file system. This overview describes the environment, design, and features of the file system, and ends with a summary of how it &amp;amp;quot;feels &amp;amp;quot; to end users and to system administrators.
Influence of Rough Runways on Undercarriage Design (1985)

A number of aspects of landing gear design are introduced in order to examine the design impact when providing a rough ground capability.
Open online transaction processing with the TUXEDO system (2003)

The authors present an overview of the TUXEDO Enterprise Transaction Processing System, which provides a UNIX system-based transaction processing monitor System/T, designed to enable the integration of many different components of online transaction processing (OLTP) in an open systems environment. They discuss the requirements driving open OLTP in today's market and review the TUXEDO products designed to meet those requirements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Adenovirus E1B Proteins Are Required for Accumulation of Late Viral mRNA and for Effects on Cellular mRNA Translation and Transport (1985)

Late in adenovirus infection, large amounts of viral mRNA accumulate while cell mRNA transport and translation decrease. Viruses deleted in the E1B region of type 5 adenovirus do not produce the same outcome: (i) viral mRNA synthesis by the mutants is normal, delivery to the cytoplasm is 50 to 75% of normal, but steady-state levels of viral mRNA are decreased 10-fold; (ii) cell mRNA synthesis and transport continue normally in the mutant virus-infected cell; and (iii) translation of preexisting cell mRNA which is disrupted in wild-type infection remains normal in mutant-virus-infected cells. Thus E1B proteins are required for accumulation of virus mRNA and for induction of the failure of host cell mRNA transport and translation. If a single function is involved, by inference the transport and some aspect of translation of mRNAs could be linked.