gebhart/patrepeval huggingface dataset:
Endocannabinoids and the Regulation of Bone Metabolism (2008)

In mammals, including humans, bone metabolism is manifested as an ongoing modelling/remodelling process whereby the bone mineralised matrix is being continuously renewed. Recently, the main components of the endocannabinoid system have been reported in the skeleton. Osteoblasts, the bone forming cells, and other cells of the osteoblastic lineage, as well as osteoclasts, the bone resorbing cells, and their precursors, synthesise the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG). CB(1) cannabinoid receptors are present in sympathetic nerve terminals in close proximity to osteoblasts. Activation of these CB(1) receptors by elevated bone 2-AG levels communicates brain-to-bone signals as exemplified by traumatic brain injury-induced stimulation of bone formation. In this process, the retrograde CB(1) signalling inhibits noradrenaline release and alleviates the tonic sympathetic restrain of bone formation. CB(2) receptors are expressed by osteoblasts and osteoclasts. Their activation stimulates bone formation and suppresses bone resorption. CB(2)-deficient mice display a markedly accelerated age-related bone loss. Ovariectomy-induced bone loss can be both prevented and rescued by a CB(2) specific agonist. Hence, synthetic CB(2) ligands, which are stable and orally available, provide a basis for developing novel anti-osteoporotic therapies, free of psychotropic effects. The CNR2 gene (encoding CB(2)) in women is associated with low bone mineral density, offering an assay for identifying females at risk of developing osteoporosis.
Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase (1992)

The binding of phosphatidylinositol-3-kinase to the polyomavirus middle T antigen is facilitated by tyrosine phosphorylation of middle T on residue 315. The pp85 subunit of phosphatidylinositol-3-kinase contains two SH2 domains, one in the middle of the molecule and one at the C terminus. When assayed by blotting with phosphorylated middle T, the more N-terminal SH2 domain is responsible for binding to middle T. When assayed in solution with glutathione S transferase fusions, both SH2s are capable of binding phosphorylated middle T. While both SH2 fusions can compete with intact pp85 for binding to middle T, the C-terminal SH2 is the more efficient of the two. Interaction between pp85 or its SH2 domains and middle T can be blocked by a synthetic peptide comprising the tyrosine phosphorylation sequence around middle T residue 315. Despite the fact that middle T can interact with both SH2s, these domains are not equivalent. Only the C-terminal SH2-middle T interaction was blocked by anti-SH2 antibody; the two SH2 fusions also interact with different cellular proteins.
alpha-2,8-Polysialic acid is the neuronal surface receptor of antennapedia homeobox peptide. (1991)

A synthetic peptide that is 60 amino acids in length and corresponds to the homeobox sequence of antennapedia protein (pAntp) is specifically and efficiently captured by neurons in culture and conveyed to their nuclei. The internalization process is followed by a strong induction of neuronal morphological differentiation. In the study described here, all treatments masking or removing the alpha-2,8-polysialic acid (PSA) chains specific to the neuronal cell adhesion molecule (NCAM) were found to block the penetration of pAntp and abolish its morphogenetic effects. Structural comparison between PSA and double-stranded DNA suggests that a sequence of eight sialic acid residues can mimic one large groove of the DNA. We propose that this structural similarity is the basis for the property of NCAM polysialic acid to participate in the internalization of the homebox polypeptide.
Hexapyrrolylbenzene and Octapyrrolylnaphthalene (1996)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTHexapyrrolylbenzene and OctapyrrolylnaphthaleneH. A. M. Biemans, C. Zhang, P. Smith, H. Kooijman, W. J. J. Smeets, A. L. Spek, and E. W. MeijerView Author Information Laboratory of Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands, UNIAX Corporation, Santa Barbara, California 93117, ETH Zürich, Materials Department, Institute for Polymers, ETH-Zentrum, Universitätstrasse 41, CH-8092 Zürich, Switzerland, and Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Cite this: J. Org. Chem. 1996, 61, 25, 9012–9015Publication Date (Web):December 13, 1996Publication History Received24 June 1996Published online13 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961192chttps://doi.org/10.1021/jo961192cbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1438Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Crystals,Hydrocarbons,Molecules,Pyrroles Get e-Alerts
Web resources for language modeling in conversational speech recognition (2007)

This article describes a methodology for collecting text from the Web to match a target sublanguage both in style (register) and topic. Unlike other work that estimates n-gram statistics from page counts, the approach here is to select and filter documents, which provides more control over the type of material contributing to the n-gram counts. The data can be used in a variety of ways; here, the different sources are combined in two types of mixture models. Focusing on conversational speech where data collection can be quite costly, experiments demonstrate the positive impact of Web collections on several tasks with varying amounts of data, including Mandarin and English telephone conversations and English meetings and lectures.
Near-Infrared Spectroscopy: A Potential Method for Continuous, Transcutaneous Monitoring for Compartmental Syndrome in Critically Injured Patients (1999)

NIRS detects muscle ischemia caused by CS despite severe hypotension and hypoxemia, making it potentially useful in critically injured, unstable patients.
ChemInform Abstract: Mono and Bis Double Ester Prodrugs of Novel Aminomethyl‐THF 1β‐Methylcarbapenems. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dichloroallyl lawsone (1979)

Dichloroallyl lawsone (DCL, NSC-126771), a synthetic analogue of the antimalarial lapachol, is potentially useful in cancer chemotherapy. Unlike most anticancer agents, DCL is not significantly myelosuppressive in animals but it induces acute cardiac toxicity in the rhesus monkey. This cardiac toxicity seems to be correlated with the maximal plasma DCL concentration, about 130 mg/L in the monkey. We have studied DCL pharmacokinetics in patients in an attempt to define safe dose limits for the Phase I clinical trial. After the rapid intravenous infusion of 10 mg/m2 of radioactive [1- or 4-14C]DCL, 250 muCi per patient, the mean peak plasma concentration of unchanged DCL in four patients was 2.9 +/- 0.3 mg/L. The drug had a mean initial plasma half-life of 48.9 +/- 19 min and a terminal half-life of 20.3 +/- 1.8 hr, with a C X t of 50.1 +/- 12 mg/L/hr, and a clearance rate of 0.08 ml/kg/min. These data suggest that in clinical trials the DCL dose given by rapid intravenous infusion should not exceed 450 mg/m2 so that the maximal plasma drug concentration remains below 130 mg/L.
From control flow to dataflow (1991)

Are imperative languages tied inseparably to the von Neumann model or can they be implemented in some natural way on data-flow architectures? In this paper, we show how imperative language programs can be translated into dataflow graphs and executed on a dataflow machine like Monsoon. This translation can exploit both fine-grain and coarse-grain parallelism in imperative language programs. More importantly, we establish a close connection between our work and current research in the imperative languages community on data dependences, control dependences, program dependence graphs, and static single assignment form. These results suggest that dataflow graphs can serve as an executable intermediate representation in parallelizing compilers.
Passive transmission of ischemic ST segment changes in low electrical resistance myocardial infarct scar in the pig (1998)

A one-month-old transmural infarction is a low resistance, noncapacitative medium that allows a good transmission of current pulses and of ST segment potential changes generated by contiguous peri-infarction ischemia.
Ananta (2013)

Layer-4 load balancing is fundamental to creating scale-out web services. We designed and implemented Ananta, a scale-out layer-4 load balancer that runs on commodity hardware and meets the performance, reliability and operational requirements of multi-tenant cloud computing environments. Ananta combines existing techniques in routing and distributed systems in a unique way and splits the components of a load balancer into a consensus-based reliable control plane and a decentralized scale-out data plane. A key component of Ananta is an agent in every host that can take over the packet modification function from the load balancer, thereby enabling the load balancer to naturally scale with the size of the data center. Due to its distributed architecture, Ananta provides direct server return (DSR) and network address translation (NAT) capabilities across layer-2 boundaries. Multiple instances of Ananta have been deployed in the Windows Azure public cloud with combined bandwidth capacity exceeding 1Tbps. It is serving traffic needs of a diverse set of tenants, including the blob, table and relational storage services. With its scale-out data plane we can easily achieve more than 100Gbps throughput for a single public IP address. In this paper, we describe the requirements of a cloud-scale load balancer, the design of Ananta and lessons learnt from its implementation and operation in the Windows Azure public cloud.
Braided Block Codes (2009)

A new class of binary iteratively decodable codes with good decoding performance is presented. These codes, called braided block codes (BBCs), operate on continuous data streams and are constructed by interconnection of two component block codes. BBCs can be considered as convolutional (or sliding) version of either Elias' product codes or expander codes. In this paper, we define BBCs, describe methods of their construction, analyze code properties, and study asymptotic iterative decoding performance.
Long-term changes in atmospheric electrical parameters observed at Nagycenk (Hungary) and the UK observatories at Eskdalemuir and Kew (2003)

Abstract. The Nagycenk Geophysical Observatory in Hungary (47° 38 ' N, 16° 43 ' E) has made continuous measurements of the vertical atmospheric electric Potential Gradient (PG) since 1962. Global signals have previously been identified in the Nagycenk PG data. A long-term (1920–1981) decrease has been discovered in the PG measured at the Eskdalemuir Observatory, Scotland (55° 19 ' N, 3° 12 ' W), suggesting that this represents a global change in the atmospheric electricity related to a decline in cosmic rays. A 40% decline in PG is shown here to have occurred at Nagycenk between 1962 and 2001, also consistent with changes in the air-Earth current measured at Kew (51° 28 ' N, 0° 19 ' W), London, 1966–1978. Comparison of the long-term PG measurements at both Eskdalemuir and Nagycenk gives further evidence to support the hypothesis of a global atmospheric electrical decline from the early twentieth century to the present time, as it is shown that local effects at Nagycenk are unlikely to have dominated the changes there.Key words. Meteorology and atmospheric dynamics (atmospheric electricity)
Compression-molded polyurethane block copolymers. 2. Evaluation of microphase compositions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompression-molded polyurethane block copolymers. 2. Evaluation of microphase compositionsJeffrey T. Koberstein and Louis M. LeungCite this: Macromolecules 1992, 25, 23, 6205–6213Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ma00049a018https://doi.org/10.1021/ma00049a018research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations99LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Opioids Induce Renal Abnormalities in Tumor-Bearing Mice (2007)

The chronic use of clinically relevant doses of opioidsleads to structural kidney abnormalities, upregulates NOS, COX-2 and HO-1, and results in renal dysfunction in a murine model of cancer.
Four New 12-Deoxyphorbol Diesters From Croton californicus (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour New 12-Deoxyphorbol Diesters From Croton californicusPedro I. Chavez, Shivanand D. Jolad, Joseph J. Hoffmann, and Jack R. ColeCite this: J. Nat. Prod. 1982, 45, 6, 745–748Publication Date (Print):November 1, 1982Publication History Published online1 July 2004Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/np50024a020https://doi.org/10.1021/np50024a020research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vaccination with Dendritic Cells Transfected with BAK and BAX siRNA Enhances Antigen-Specific Immune Responses by Prolonging Dendritic Cell Life (2005)

Dendritic cell-based vaccines have become an important approach for the treatment of malignancies. Numerous techniques have recently been designed to optimize dendritic cell activation, tumor antigen delivery to dendritic cells, and induction of tumor-specific immune responses in vivo. Dendritic cells (DCs), however, have a limited life span because they are subject to apoptotic cell death mediated by T cells, hindering their long-term ability to prime antigen-specific T cells. Small interfering RNA targeting Bak and Bax antiapoptotic proteins can be used to allow transfected DCs to resist killing by T cells in vivo. In this study, we show that human papillomavirus E7-loaded dendritic cells transfected with BAK/BAX siRNA downregulate Bak and Bax protein expression and become resistant to killing by T cells, leading to enhanced E7-specific CD8+ T cell activation and antitumor effects in vivo. More importantly, we found that vaccination with E7-loaded DCs transfected with BAK/BAX siRNA was capable of generating a strong therapeutic effect in vaccinated mice, compared with DCs transfected with control siRNA. Our data indicate that transfection of dendritic cells with BAK/BAX siRNA represents a plausible strategy for enhancing dendritic cell-based vaccine potency.
A novel parsley 4CL1 cis‐element is required for developmentally regulated expression and protein‐DNA complex formation (1999)

The phenylpropanoid enzyme 4-coumarate:coenzyme A ligase (4CL) participates in the biosynthesis of a wide range of secondary products with specialized function and tissue distribution in plants. The parsley 4CL1 promoter directs a complex tissue- and cell-specific pattern of reporter gene expression in transgenic tobacco, consistent with the distribution of phenylpropanoid products and sites of 4CL expression in tobacco vegetative and floral organs. We generated mutants in a 4CL1 promoter element previously implicated as a site for protein-DNA complex formation to analyze its role in vivo. Mutation of this element (FP56) reduced expression in some organs/tissues up to several hundredfold, with little effect on cell-specific expression patterns. Electrophoretic mobility shift assays indicated that the FP56 cis-element is the binding site for tobacco and parsley nuclear proteins, and that mutations in the same element that reduce reporter gene expression in transgenic plants greatly reduce or abolish protein-DNA complex formation. DNAse I protection assays showed that the region of the 4CL1 promoter surrounding the FP56 element is the site for formation of two large protein-DNA complexes, and that an intact FP56 element is required for formation of these complexes. Finally, the detergent deoxycholate was used to investigate the role of protein-protein interactions in FP56 complex formation. Our data suggest that the FP56 cis-element plays a central role in transcriptional activation from the 4CL1 promoter, and that its role may be to nucleate formation of a large protein complex on the promoter.
One ring or two? Determination of ring number in carotenoids by lycopene ɛ-cyclases (2001)

Carotenoids in the photosynthetic membranes of plants typically contain two beta-rings (e.g., beta-carotene and zeaxanthin) or one epsilon- and one beta-ring (e.g., lutein). Carotenoids with two epsilon-rings are uncommon. We reported earlier that the Arabidopsis thaliana lycopene epsilon-cyclase (LCYe) adds one epsilon-ring to the symmetrical linear substrate lycopene, whereas the structurally related lycopene beta-cyclase (LCYb) adds two beta-rings. Here we describe a cDNA encoding LCYe in romaine lettuce (Lactuca sativa var. romaine), one of the few plant species known to accumulate substantial quantities of a carotenoid with two epsilon-rings: lactucaxanthin. The product of the lettuce cDNA, similar in sequence to the Arabidopsis LCYe (77% amino acid identity), efficiently converted lycopene into the bicyclic epsilon-carotene in a heterologous Escherichia coli system. Regions of the lettuce and Arabidopsis epsilon-cyclases involved in the determination of ring number were mapped by analysis of chimeric epsilon-cyclases constructed by using an inverse PCR approach. A single amino acid was found to act as a molecular switch: lettuce LCYe mutant H457L added only one epsilon-ring to lycopene, whereas the complementary Arabidopsis LCYe mutant, L448H, added two epsilon-rings. An R residue in this position also yields a bi-epsilon-cyclase for both the lettuce and Arabidopsis enzymes. Construction and analysis of chimera of related enzymes with differing catalytic activities provide an informative approach that may be of particular utility for studying membrane-associated enzymes that cannot easily be crystallized or modeled to existing crystal structures.
Pneumonic Plague in an Untreated Plague-Vaccinated Individual (1967)

A 50-year old American immunization technician in South Vietnam was discovered to have pneumonic plague eight days after the onset of fever, chills, pleuretic chest pain, and a cough productive of large amounts of bloody sputum. His survival, untreated, for that period of time with a disease renowned for its rapid lethality suggests that prior immunizations with killed and living vaccines significantly altered the natural course of the disease.
Induction of splice correction by cell‐penetrating peptide nucleic acids (2006)

These data demonstrate that CPPs can be used for the delivery of splice-correcting PNAs, with potential to be used as a therapeutic approach for regulating splicing in a variety of diseases. Transportan presents itself as the overall most suitable vector in this study, generating the most efficient conjugates for splice correction.
??-tricalcium Phosphate Delivery System for Bone Morphogenetic Protein (1984)

An aggregate of biodegradable beta-tricalcium phosphate and bone morphogenetic protein (BMP/TCP) induces the differentiation of cartilage within eight days, cartilage and woven bone within 12 days, and lamellar bone, including bone marrow, within 21 days. The yield of new bone from a 1-mg dose was more than 12 times greater from the TCP/BMP than from the BMP alone. Whether TCP acts as a slow-release delivery system, potentiates the activity of BMP, or serves to distribute BMP in a favorable three-dimensional pattern requires further investigation.
Session details: The X Architecture: Not your father's diagonal wiring (2002)

No abstract available.
A Wireless Sensor Network for Real-Time Indoor Localisation and Motion Monitoring (2008)

This paper describes the development and deployment of a wireless sensor network for monitoring human motion and position in an indoor environment. Mobile sensor nodes comprising mote-type devices, along with inertial sensors are worn by persons moving inside buildings. Motion data is preprocessed onboard mobile nodes and transferred to a static network of seed nodes using a delay tolerant protocol with minimal radio packet overhead. A Monte Carlo based localisation algorithm is implemented, which uses a person's pedometry data, indoor map information and seed node positions to provide accurate, real-time indoor location information. The performance of the network protocols and localisation algorithm are evaluated using simulated and real experimental data.