gebhart/patrepeval huggingface dataset:
A Mechanistic Study of Single-Well Steam Assisted Gravity Drainage (2000)

Abstract Single Well Steam Assisted Gravity Drainage (SW-SAGD) process was evaluated by closely examining performance of field projects in the public domain, physical modeling and numerical simulation. It was seen that in order to be economically acceptable, field implementation emphasizes the "Single Well (SW) aspects" (near well bore heating), as opposed to the "SAGD aspects" (creation of a large steam chamber). The reported steam-oil ratio of about one for SW-SAGD field projects includes contributions due to primary production. Obviously, the performance will be attractive where the primary production is strong. Presence of mobile water or gas in the vicinity of a target location will have a negative effect on performance. The economic performance can be stronger than that for primary and cyclic steam stimulation but perhaps not as strong as for a dual well steam assisted gravity drainage. Therefore targets should typically have a continuous pay thickness of 10 to 15 m. Potential improvements can be obtained from optimizing well bore configurations by way of reducing steam by-pass and extending the effective well length utilized for production during the process. Other optimizing ideas involve the use of gases as steam additives and injection-production rate scheduling. The process is essentially a variation of cyclical steam stimulation (CSS) rather than of SAGD. Using certain elements of the SW-SAGD process, one should be able to profitably modify the cyclic steam stimulation (CSS) process while using horizontal wells. Introduction The Single Well Steam Assisted Gravity Drainage (SW-SAGD) process is a steam injection based oil recovery process in which the same horizontal well is used for steam injection, as well as for oil production. Steam is injected through insulated tubing, whereas hot oil and condensed water are pumped to the surface through a separate tubing string. It was initially thought of as a variation of the dual well Steam Assisted Gravity Drainage process (SAGD). In SAGD, steam is injected via a horizontal well and heated oil and condensate produced via another horizontal well, placed directly underneath the injector. The main driving mechanism being gravity.
Treatment of murine lupus with cDNA encoding IFN-γR/Fc (2000)

IFN-gamma, a pleiotropic cytokine, is a key effector molecule in the pathogenesis of several autoimmune diseases, including lupus. Importantly, deletion of IFN-gamma or IFN-gammaR in several lupus-predisposed mouse strains resulted in significant disease reduction, suggesting the potential for therapeutic intervention. We evaluated whether intramuscular injections of plasmids with cDNA encoding IFN-gammaR/Fc can retard lupus development and progression in MRL-Fas(lpr) mice. Therapy significantly reduced serum levels of IFN-gamma, as well as disease manifestations (autoantibodies, lymphoid hyperplasia, glomerulonephritis, mortality), when treatment was initiated at the predisease stage, particularly when IFN-gammaR/Fc expression was enhanced by electroporation at the injection site. Remarkably, disease was arrested and even ameliorated when this treatment was initiated at an advanced stage. This therapy represents a rare example of disease reversal and makes application of this nonviral gene therapy in humans with lupus (and perhaps other autoimmune/inflammatory conditions) highly promising.
Biomimetic materials replicating Schwann cell topography enhance neuronal adhesion and neurite alignment in vitro (2007)

It is well established that Schwann cells (SCs) promote and enhance axon guidance and nerve regeneration by providing multiple cues, including extracellular matrix, cell surface molecules, neurotrophic factors and cellular topography. Which of the elements of the complex environment associated with SCs provides the essential information for directed nerve growth is unclear, because, until now, it has been impossible to investigate their contributions individually. Our development of biomimetic materials that replicate the micro- and nanoscale topography of SCs has allowed us to investigate for the first time the role of cellular topography in directing nerve growth. Dorsal root ganglion (DRG) neurons were cultured on flat poly(dimethyl siloxane) (PDMS) and on PDMS replicas with protruding SC topography. Image analysis showed that more neurons adhered to the replicas than to the flat substrates, and that neurite growth on the replicas followed the underlying SC pattern. Neuronal alignment was dependent on cell density. Live SCs derived from the DRG also grew along the replica SC pattern. These results suggest that the combination of micro- and nanoscale topographical cues provided by SCs can influence nerve growth and point toward design parameters for future nerve guidance channels.
Antibiotic Susceptibility Testing at a Screen-Printed Carbon Electrode Array (2008)

Screen-printed carbon electrode arrays were treated to allow respiratory activity-based measurement of antibiotic susceptibility with Escherichia coli JM105. Carbon working electrodes were examined for antibiotic adsorption and were pretreated with various electrochemical and chemical protocols to minimize antibiotic adsorption. Treatment by voltammetry in basic solution or by chemical modification with poly-L-lysine or chitosan were found to be effective methods for the elimination of adsorption of the studied group of 17 antibiotics, which comprised several classes and modes of action. Measurements consisted of two-electrode amperometry of the bacterial suspension after 10 min of incubation with antibiotic followed by addition of an oxidative cocktail of ferricyanide and dichlorophenolindophenol for a further 10 min; response currents, which indicate the extent of reduction of ferricyanide to ferrocyanide by cellular respiratory activity, decrease with increasing concentration of antibiotic present in the initial 10 min incubation. IC50 values obtained for chloramphenicol with these electrode modification methods are consistent at 2.0 +/- 0.2 mM, in approximate agreement with previously reported respiration-based results for this organism but significantly higher than values reported for growth-based antibiotic susceptibility testing methods.
Bandwidth efficient differential phase shift keying (PSK) techniques for TDMA applications (2003)

A class of bandwidth efficient differential phase shift keying (DPSK) signals is presented, and their performance is analyzed. Compact bandwidth, constant envelope, fast demodulation, and nonredundant forward-error-correction properties make the proposed signals attractive for TDMA (time-division multiaccess) applications such as point-to-multipoint radio systems, mobile communications, and others. DPSK demodulation can be made insensitive to the carrier-frequency drift, so that it is suitable to Doppler and slow-fading environments.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: The C‐H×××O Hydrogen Bond in Crystals: What Is It? (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Determining Risk of Biochemical Recurrence in Prostate Cancer by Immunohistochemical Detection of PTEN Expression and Akt Activation (2007)

Our results indicate that loss of PTEN expression, together with increased Akt phosphorylation and Gleason score, is of significant predictive value for determining, at the time of prostatectomy, the risk of biochemical recurrence.
Client-driven channel management for wireless LANs (2006)

With the explosive growth in the density of 802.11 access points (APs) in the form of hotspots and public/home access networks, coordinating the shared use of spectrum has become an important problem. The irregular coverage topologies present in WLANs due to the vagaries of the indoor RF environment make the channel assignment algorithms in cellular networks inapplicable [1, 2].
Surface-Localized Protein Antigens of Group B Streptococci (1988)

There are three major surface-localized protein antigens of group B streptococci: c, R, and X. Their precise role in human immunity to group B streptococci has not been defined. Studies of the c protein suggested that type II strains possessing both trypsin-resistant and trypsin-sensitive components of the c protein were less easily killed in vitro and were more virulent in an infant rat model of infection as compared with type II strains that do not bear these proteins. The c protein components were immunogenic in mice and rabbits. Polyclonal rabbit antisera were protective in the infant rat model of bacteremia/sepsis and facilitated killing of type II strains bearing the c protein in an in vitro opsonophagocytic bacterial killing assay. The role of the IgA-binding capacity of the c protein in altering the interaction of group B streptococcal strains with host defenses remains undefined at this time.
The effect of the nature of the amine leaving group on the nature of the E2 transition state for the reaction of 1-phenylethylammonium ions with sodium ethoxide in ethanol (1989)

To investigate the effect of the leaving group on the elimination reaction of 1-phenylethylammonium ions with sodium ethoxide in ethanol at 60 °C, the reaction of seven different quaternary ammonium salts and their β-deuterated analogues with trimethylamine, N-methylpiperidine, N-methyldiethylamine, triethylamine, N,N-dimethylbenzylamine, tripropylamine, and N,N-diethylbenzylamine as leaving groups has been studied. In all cases the elimination, which was shown to proceed via the concerted E2 process, was accompanied by competing substitution reactions. Although a significant dependence of the rate of the elimination process on the nature of the leaving group was noted, there was not any linear correlation with the basicity of the amine leaving group. The primary hydrogen–deuterium kinetic isotope effect for the elimination process, (k H /k D ) E , was found to increase initially with an increase of reaction rate, [Formula: see text] for substrates containing the leaving groups trimethylamine, N-methylpiperidine, N-methyldiethylamine, triethylamine, and N,N-dimethylbenzylamine; i.e., (k H /k D ) E = 5.03, 5.26, 5.40, 5.83, and 5.85, respectively. A further increase in rate, using substrates with tripropylamine and N,N-diethylbenzylamine as leaving groups resulted in a decrease of the magnitude of the hydrogen–deuterium isotope effect; i. e., (k H /k D ) E = 5.42 and 4.67, respectively. It is concluded that steric effects mainly determine leaving group ability. As well, it is concluded that the leaving group ability of the amine determines the structure of the E2 transition state. For the reaction of the poorer leaving groups, trimethylamine, N-methylpiperidine, and N-methyldiethylamine, the proton is morethan one-half transferred at the transition state while for reaction involving the two best leaving groups, tripropylamine and N,N-diethylbenzylamine, the C β —H bond is lessthan one-half broken at the transition state. The conclusions are considered in the light of the More O'Ferrall – Jencks potential energy surface diagram. Keywords: elimination mechanism, transition state, isotope effects, leaving group, quaternary salts.
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome (2007)

Cutaneous T-cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in the skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disease and its management. Based on 63 skin samples, we performed consensus clustering, revealing 3 patient clusters. Of these, 2 clusters tended to differentiate limited CTCL (stages IA and IB) from more extensive CTCL (stages IB and III). Stage IB patients appeared in both clusters, but those in the limited CTCL cluster were more responsive to treatment than those in the more extensive CTCL cluster. The third cluster was enriched in lymphocyte activation genes and was associated with a high proportion of tumor (stage IIB) lesions. Survival analysis revealed significant differences in event-free survival between clusters, with poorest survival seen in the activated lymphocyte cluster. Using supervised analysis, we further characterized genes significantly associated with lower-stage/treatment-responsive CTCL versus higher-stage/treatment-resistant CTCL. We conclude that transcriptional profiling of CTCL skin lesions reveals clinically relevant signatures, correlating with differences in survival and response to treatment. Additional prospective long-term studies to validate and refine these findings appear warranted.
Designing a VAX for high performance (2002)

The strategy used by the designers to achieve the high performance of the VAX 9000 is described. The strategy chosen was to apply reduced-instruction-set-computer-like techniques in implementing the VAX architecture. VAX instructions were broken into small, simple tasks, and dedicated hardware optimized for each task was designed. The result is a network of specialized processors, operating in parallel, executing instructions quickly. The most common, simple instructions are executed at the rate of 1/cycle. To increase system performance further, a high-density, high-speed technology was specifically developed for the VAX 9000. Emitter-coupled-logic (ECL) macrocell arrays (MCA3s), high-density signal carriers (HDSCs), and multichip units (MCUs) allow efficient use of limited physical area. The VAX 9000 scalar and vector processors reside on a single planar board. Three MCU slots are reserved for the optional VBOX vector processor. Integrating the vector processor directly with the scalar processor kept critical interconnects short, reducing vector instruction overhead.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Characterization of the purified components of a new homologous series of alpha-mycolic acids from Mycobacterium tuberculosis H37Ra (1978)

Homologous series of alpha-mycolic acids from Mycobacterium tuberculosis H37Ra were separated according to size as their p-bromophenacyl ester by bonded C18 reverse-phase, high performance liquid chromatography. Mass spectrometry of the prominent components separated by high performance liquid chromatography gave relatively simple spectra and showed a series of components differing by 28 atomic mass units. A total of different structures were identified. The structures were established as follow: (formula see text) where a = 17, 18, 19; b = 10; c = 15, 17, 19, 21; and d = 21, 23. The C76 and C78 acids contained some C24 alpha-branch acid (d - 21), whereas the C80 and C82 acids contained some a = 19 acids. Several new homologous series were revealed.
Microbial Pretreatment of Biomass (2003)

Typical pretreatment requires high-energy (steam and electricity) and corrosion-resistant, high-pressure reactors. A review of the literature suggests that fungal pretreatment could potentially lower the severity requirements of acid, temperature and time. These reductions in severity are also expected to result in less biomass degradation and consequently lower inhibitor concentrations compared to conventional thermochemical pretreatment. Furthermore, potential advantages of fungal pretreatment of agricultural residues, such as corn stover, are suggested by its effectiveness in improving the cellulose digestibility of many types of forage fiber and agricultural wastes. Our preliminary tests show a three- to five-fold improvement in enzymatic cellulose digestibility of corn stover after pretreatment with Cyathus stercoreus; and a ten- to 100-fold reduction in shear force needed to obtain the same shear rate of 3.2 to 7 rev/s, respectively, after pretreatment with Phanerochaete chrysosporium.
Preparation and Characterization of InxSey Thin Films Deposited by Co-Evaporation (2000)

InxSey thin films were deposited by co-evaporation of In and Se and characterized through XRD (X-ray diffraction), spectral transmittance and AFM (atomic force microscopy) measurements. This material will later be employed as buffer layer and/or as precursor of CuInSe2(CIS) thin films used as absorber layer in thin film solar cells. The aim of this work is to obtain deposition conditions for InxSey films to use them in substitution of the CdS layer which is a toxic material generally used as buffer in CIS based solar cells.
Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats (2001)

Hepatocyte growth factor (HGF) was originally discovered as a powerful mitogen for hepatocytes. HGF also has been reported to function as a neurotrophic factor as well as an angiogenetic factor. The present study examined the neuroprotective effect of HGF against transient focal cerebral ischemia in rats, in which an anti-apoptotic and an angiogenetic effect of HGF was assumed to contribute to the reduction of the infarct volume. The intraventricular administration of human recombinant HGF prevented neuronal death after 120 min of occlusion in the right middle cerebral artery and the bilateral common carotid arteries. HGF significantly reduced the infarct volume in a dose-dependent manner. In a separate series of experiments, we next histopathologically investigated both the anti-apoptotic effect on neurons and the angiogenetic effect of HGF. A large number of TUNEL positive neurons were observed in the inner boundary of the infarct area in both the control and the vehicle group whereas only a few TUNEL positive neurons were observed in the corresponding area in the HGF group. In the HGF group, Bcl-2 protein was obviously represented in surviving neurons subjected to ischemia. The number of the vascular lamina in HGF group were significantly higher than those in the vehicle group. These data suggest that HGF appears to have an ability to prevent apoptotic neuronal cell death while also possessing an angiogenetic effect in the central nervous system which was affected with transient focal cerebral ischemia.
In vitro resistance to platelet microbicidal protein correlates with endocarditis source among bacteremic staphylococcal and streptococcal isolates (1994)

Traditionally, platelets have been thought to contribute to the induction and propagation of infective endocarditis (IE). However, recent studies suggest that platelets may potentially mitigate IE via secretion of alpha-granule-derived platelet microbicidal protein (PMP). In this study, we compared the PMP susceptibility of bacteremic isolates from patients with and without IE. Isolates of Staphylococcus aureus (n = 17), coagulase-negative staphylococci (CNS; n = 28), viridans streptococci (VS; n = 54), and Enterococcus faecalis (n = 20), each at a final inoculum of 2 x 10(3) CFU/ml, were exposed to PMP [100 U/ml, (5 micrograms/ml)] for 2 h, and the percent survival was determined. For S. aureus, CNS, and VS isolates, there was a significant correlation between an IE source and increased percent survival post-PMP exposure; the mean percent survivals of S. aureus, CNS, and VS were significantly greater for IE versus non-IE isolates (P < 0.005 for each organism). No significant correlation was observed between the source of bacteremic E. faecalis isolates and PMP susceptibility. These data suggest that staphylococcal and VS (but not enterococcal) resistance to PMP may facilitate either the induction or progression of IE.
Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control (2000)

Numerous studies have implicated the pRB family of nuclear proteins in the control of cell cycle progression. Although over-expression experiments have revealed that each of these proteins, pRB, p107, and p130, can induce a G(1) cell cycle arrest, mouse knockouts demonstrated distinct developmental requirements for these proteins, as well as partial functional redundancy between family members. To study the mechanism by which the closely related pRB family proteins contribute to cell cycle progression, we generated 3T3 fibroblasts derived from embryos that lack one or more of these proteins (pRB(-/-), p107(-/-), p130(-/-), pRB(-/-)/p107(-/-), pRB(-/-)/p130(-/-), and p107(-/-)/p130(-/-)). By comparing the growth and cell cycle characteristics of these cells, we have observed clear differences in the manner in which they transit through the G(1) and S phases as well as exit from the cell cycle. Deletion of Rb, or more than one of the family members, results in a shortening of G(1) and a lengthening of S phase, as well as a reduction in growth factor requirements. In addition, the individual cell lines showed differential regulation of a subset of E2F-dependent gene promoters, as well as differences in cell cycle-dependent kinase activity. Taken together, these observations suggest that the closely related pRB family proteins affect cell cycle progression through distinct biochemical mechanisms and that their coordinated action may contribute to their diverse functions in various physiological settings.