gebhart/patrepeval huggingface dataset:
Human mesenchymal stem cells attenuate early damage in a ventilated pig model of acute lung injury (2016)

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a major cause of global morbidity and mortality. Mesenchymal stem cells (MSC) have shown promise in treating inflammatory lung conditions. We hypothesised that human MSC (hMSC) can improve ALI/ARDS through their anti-inflammatory actions. We subjected pigs (n=6) to intravenous oleic acid (OA) injury, ventilation and hMSC infusion, while the controls (n=5) had intravenous OA, ventilation and an infusion vehicle control. hMSC were infused 1h after the administration of OA. The animals were monitored for additional 4h. Nuclear translocation of nuclear factor-light chain enhancer of activated B cells (NF-κB), a transcription factor that mediates several inflammatory pathways was reduced in hMSC treated pigs compared to controls (p=0.04). There was no significant difference in lung injury, assessed by histological scoring in hMSC treated pigs versus controls (p=0.063). There was no difference in neutrophil counts between hMSC-treated pigs and controls. Within 4h, there was no difference in the levels of IL-10 and IL-8 pre- and post-treatment with hMSC. In addition, there was no difference in hemodynamics, lung mechanics or arterial blood gases between hMSC treated animals and controls. Subsequent studies are required to determine if the observed decrease in inflammatory transcription factors will translate into improvement in inflammation and in physiological parameters over the long term.
Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction (2011)

Templated DNA strand ligation by the ring-strain promoted alkyne-azide [3+2] cycloaddition reaction is very fast; with dibenzocyclooctyne, the reaction is essentially complete in 1 min. It is inhibited by the presence of a single mismatched base pair suggesting applications in genetic analysis.
Highly Sensitive Determination of microRNA Using Target‐Primed and Branched Rolling‐Circle Amplification (2009)

One-nucleotide differences in microRNAs (miRNAs) can be discriminated in an assay based on a branched rolling-circle amplification (BRCA) reaction and fluorescence quantification. With the proposed method miRNA can be detected at concentrations as low as 10 fM, and the miRNA in a total RNA sample of a few nanograms can be determined.
Pharmacologic Options for Reducing the Shivering Response to Therapeutic Hypothermia (2010)

Recent literature has demonstrated significant improvements in neurologic outcomes in patients who have received induced hypothermia in the setting of out-of-hospital cardiac arrest. Through multiple metabolic mechanisms, the induction of hypothermia slows the progression and devastation of transient cerebral hypoxia. Despite these benefits, the desired reduction in core temperature is often a challenging venture as the body attempts to maintain homeostasis through the induction of thermoregulatory processes aimed at elevating body temperature. Shivering is an involuntary muscular activity that enhances heat production in an attempt to restore homeostasis. For successful induction and maintenance of induced hypothermia, shivering, as well as other thermoregulatory responses, must be overcome. Several pharmacologic options are available, either used alone or in combination, that safely and effectively prevent or treat shivering after the induction of hypothermia. We conducted a PubMed search (1966-March 2009) to identify all human investigations published in English that discussed pharmacologic mechanisms for the control of shivering. Among these options, clonidine, dexmedetomidine, and meperidine have demonstrated the greatest and most clinically relevant impact on depression of the shivering threshold. More research in this area is needed, however, and the role of the clinical pharmacist in the development and implementation of this therapy needs to be defined.
EDITORIAL (2013)

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An Investigation of the Use of Microwave Radiation for Pulmonary Diagnostics (1976)

This communication describes a new technique in which penetrating microwave radiation is used for the diagnosis and monitoring of pathological cardiopulmonary conditions, such as pulmonary edema. Edema causes changes in the electromagnetic characteristics of the lung tissue, which in turn produces a change in the reflected and transmitted microwave radiation. Both the amplitude and phase changes of the microwave signals are measured.
Análisis estructural del flanco norte del anticlinorio de Bilbao en la transversal de La Reineta-Urioste (Vizcaya) (1997)

There are two independent mol-ecules in the asymmetric unit of the title compound, C(13)H(14)N(2)O(2), in which the dihedral angles between the substituted phenyl ring and the pyrazole ring are 86.5 (2) and 82.3 (3)°. The crystal packing features weak inter-molecular C-H⋯O inter-actions.
The use of feline herpesvirus and baculovirus as vaccine vectors for the gag and env genes of feline leukaemia virus (1992)

The env and gag genes from feline leukaemia virus were expressed in a thymidine kinase-negative feline herpes-virus and a baculovirus. Cats were vaccinated with various combinations of these recombinant viruses and 100% protection against feline leukaemia virus challenge was achieved using an immunization schedule which utilized both env and gag products delivered at both a mucosal and systemic site.
Endoscopy in Pediatric Inflammatory Bowel Disease (2018)

Endoscopy is a central tool for the evaluation and management of inflammatory bowel disease (IBD). In the last few decades, gastrointestinal (GI) endoscopy has undergone significant technological developments including availability of pediatric-size equipment, enabling comprehensive investigation of the GI tract in children. Simultaneously, professional organization of GI experts have developed guidelines and training programs in pediatric GI endoscopy. This prompted the Porto Group on Pediatric IBD of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition to develop updated guidelines on the role of GI endoscopy in pediatric IBD, specifically taking into considerations of recent advances in the diagnosis, disease stratification, and novel therapeutic targets in these patients.
Electrodeposition of Al-Zr Alloys from Lewis Acidic Aluminum Chloride-1-Ethyl-3-methylimidazolium Chloride Melt (2004)

The electrochemistry of Zr(IV) and Zr(II) and the electrodeposition of Al-Zr alloys were examined in the Lewis acidic 66.7-33.3 mol % aluminum chloride-1-ethyl-3-methylimidazolium chloride molten salt at 353 K. The electrochemical reduction of Zr(IV) to Zr(II) is complicated by the precipitation of however, solutions of Zr(II) can be prepared by reducing Zr(IV) with Al wire. Al-Zr alloys can be electrodeposited from plating baths containing either Zr(IV) or Zr(II), but for a given concentration and current density, baths containing Zr(IV) lead to Al-Zr alloys with the higher Zr content. This result was traced to the diminutive concentration-dependent diffusion coefficient for Zr(II). It was possible to prepare Al-Zr alloys containing up to ∼17% atomic fraction (atom %) Zr. The structure of these deposits depended on the Zr content. Alloys containing less than 5 atom % Zr could be indexed to a disordered face-centered cubic structure similar to pure Al, whereas alloys containing ∼17 atom % Zr were completely amorphous (metallic glass). The chloride pitting potentials of alloys with more than 8 atom % Zr were approximately +0.3 V relative to pure Al. © 2004 The Electrochemical Society. All rights reserved.
Pretreatment of prosthetic valve sewing-ring with the antibiotic/fibrin sealant compound as a prophylactic tool against prosthetic valve endocarditis (1990)

Prosthetic valve endocarditis (PVE) remains a dreaded complication following heart valve replacement despite perioperative antibiotic (AB) prophylaxis. In order to increase the AB concentration in the sewing ring, an experimental study including topical application of the gentamicin derivative EMD 46/217 and fibrin sealant (F) as AB-carrier was initiated. In vitro pretreatment of Dacron with the gentamicin derivative and F was followed by constant AB release for 3 weeks. In a subsequent animal study, four Dacron rings with different pretreatment were implanted in the descending aorta of 10 pigs after direct contamination with 10(8) Staphylococcus aureus solution. One ring was pretreated with the AB/F compound, a second ring with the AB alone. Ring 3 (no pretreatment) and ring 4 (F alone) served as controls. After 1 week, the sewing rings and their corresponding implantation sites were assayed for measurement of AB-content and for culture. The AB content of AB/F-rings was 24.99 +/- 7.16 micrograms/g wet weight, while rings pretreated with the AB alone contained no measurable drug amounts with the exception of one specimen (0.5 microgram/g) (AB/F vs. AB-rings: P less than 0.0005). The corresponding implantation sites to AB/F rings contained 1.07 +/- 0.54 micrograms/g AB, whereas in only 2 of 10 implantation sites of AB rings, low AB levels were found (0.05 and 0.2 micrograms/g) (AB/F vs. AB ring implantation sites: P less than 0.0005). While all control rings and 9 of 10 AB rings were infected, 5 of 10 AB/F rings remained sterile after culture (AB/F vs. AB rings: P = 0.05). This finding correlated with the AB content in the suture rings.(ABSTRACT TRUNCATED AT 250 WORDS)
Marine Oil Fate: Knowledge Gaps, Basic Research, and Development Needs; A Perspective Based on the Deepwater Horizon Spill (2011)

The various complex forms of transport as well as many other fate processes ongoing in the marine water column require research for the understanding and prediction of impacts of deepwater releases on the marine ecosystem. Such research is useful for assessing the context and limits of future deepwater oil and gas development in the Gulf of Mexico. The Deepwater Horizon incident in the Gulf represents the first oil spill occurring at significant depth, ∼5,000 ft (1,500 m). It is also the first situation where dispersants were directly added to the hydrocarbon effluent from the wellhead in efforts to disperse the droplets over a large volume of the water column. In this regard, this perspective is an original work in that it provides an in-depth analysis of gaps and needs, which will guide future work in the field. Preliminary reports have led to a variety of images that highlight new physiochemical phenomena whose comprehensive understanding will be needed in assessing the oil and associated hydrocarbon chemical fate and environmental impact. Camera images of the oil and gas entering the water at depth and subsurface remote-operated vehicles have revealed droplet clouds and hydrocarbon plumes suspended thousands of feet below the surface moving horizontally with the water currents. Although preliminary, these and other observations are sufficient to piece together new hypothetical deepwater chemodynamic processes and phenomena that have yet to be fully understood. This position article focuses on unique and new research issues raised and relevant to this spill specifically. The ultimate fate of the oil constituents is a very broad subject. Our objective was concerned with the deepwater spill-initiating event. We focused on selected fate processes associated with the oil and dispersant chemodynamics from the blowout point, on the seabed, in the water column upward, and finally, into the marine surface mixed layer. An observation-conceived, process-based, mass balance-crafted engineering science predictive tool is proposed. It is needed for forecasting, projecting in anticipation of and managing the next spill, and answering the question “where does it all go?”
Comparison of biting forces in different age and sex groups: a study of biting efficiency with mobile and non‐mobile teeth (1999)

This study aimed (1) to investigate the influences of sex, age and number of teeth on biting ability through a descriptive survey, and (2) to compare the biting ability between the subjects with and without mobile teeth in a case-control study. A total of 687 subjects cooperated in the descriptive survey. Each subject bit on a pressure detecting sheet with their maximum biting force. Three indices of biting ability: biting pressure (MPa), biting force (N) and occlusal contact area (mm2) were calculated from the impressed marks on the sheet using a high vision video processor system. These indices were correlated well with the number of teeth according to the multiple regression analysis. In the case-control study, matching procedures with sex, age and number of teeth were performed between the subjects with and without mobile teeth. No differences in the three indices were observed between the two well-balanced groups. The results showed that the number of teeth is most important to maintain biting ability, and that the presence of mobile teeth does not always reduce biting ability.
Studies on oligonucleotide synthesis. XXXII. Synthesis of deoxyribooligonucleotides using cesium fluoride by the phosphotriester approach. (1985)

フッ化セシウムの共存下,5'-O-ジメトキシトリチル-N-アシルデオキシリボヌクレオシド3'-[O-(4-をクロロフェニル)=O'-(5-クロロ-8-キノリル)=ホスファート]とN-位を保護したデオキシリボヌクレオシドをアセトニトリル中で反応させたところ,よい収率でジデオキシリボヌクレオシドモノホスファートを与えた。この反応はデオキシリボヌクレオシドの5'-ヒドロキシル基と選択的に反応することが明らかになった。このようにして得られたジヌクレオチド誘導体はフラグメント縮合によるオリゴヌクレオチド合成に対する重要な出発原料となることがわかった。
THEORY OF PLATES AND SHELLS (1959)

CONTENTS: BENDING OF LONG RECTANGULAR PLATES TO A CYLINDRICAL SURFACE PURE BENDING OF PLATES SYMMETRICAL BENDING OF CIRCULAR PLATES SMALL DEFLECTIONS OF LATERALLY LOADED PLATES SIMPLY SUPPORTED RECTANGULAR PLATES RECTANGULAR PLATES WITH VARIOUS EDGE CONDITIONS CONTINUOUS RECTANGULAR PLATES PLATES ON ELASTIC FOUNDATION PLATES OF VARIOUS SHAPES SPECIAL AND APPROXIMATE METHODS IN THEORY OF PLATES BENDING OF ANISTROPIC PLATES BENDING OF PLATES UNDER THE COMBINED ACTION OF LATERAL LOADS AND FORCES IN THE MIDDLE PLANE OF THE PLATE LARGE DEFLECTIONS OF PLATES DEFORMATION OF SHELLS WITHOUT BENDING GENERAL THEORY OF CYLINDRICAL SHELLS SHELLS HAVING THE FORM OF A SURFACE OF REVOLUTION AND LOADED SYMMETRICALLY WITH RESPECT TO THEIR AXIS.
Adaptive radio resource allocation for multiple traffic OFDMA broadband wireless access system (2006)

在这篇文章，一个适应收音机资源分配算法适用于多重交通直角的频率分割多重存取(OFDMA ) 系统被建议，它根据他们服务要求和交通类型的不同质量在用户之中散布副载波和位。由为更高的优先级用户基于他们的交通典型、保证的资源分类并且权衡轻重用户，新计划极大地减少没有影响，在系统的光谱效率上要求即时传播的用户的停止概率，象数据的停止概率一样，用户们没与出版的收音机资源分配方法相比被增加。
The ΔF508-CFTR mutation results in increased biofilm formation byPseudomonas aeruginosaby increasing iron availability (2008)

Enhanced antibiotic resistance of Pseudomonas aeruginosa in the cystic fibrosis (CF) lung is thought to be due to the formation of biofilms. However, there is no information on the antibiotic resistance of P. aeruginosa biofilms grown on human airway epithelial cells or on the effects of airway cells on biofilm formation by P. aeruginosa. Thus we developed a coculture model and report that airway cells increase the resistance of P. aeruginosa to tobramycin (Tb) by >25-fold compared with P. aeruginosa grown on abiotic surfaces. Therefore, the concentration of Tb required to kill P. aeruginosa biofilms on airway cells is 10-fold higher than the concentration achievable in the lungs of CF patients. In addition, CF airway cells expressing DeltaF508-CFTR significantly enhanced P. aeruginosa biofilm formation, and DeltaF508 rescue with wild-type CFTR reduced biofilm formation. Iron (Fe) content of the airway in CF is elevated, and Fe is known to enhance P. aeruginosa growth. Thus we investigated whether enhanced biofilm formation on DeltaF508-CFTR cells was due to increased Fe release by airway cells. We found that airway cells expressing DeltaF508-CFTR released more Fe than cells rescued with WT-CFTR. Moreover, Fe chelation reduced biofilm formation on airway cells, whereas Fe supplementation enhanced biofilm formation on airway cells expressing WT-CFTR. These data demonstrate that human airway epithelial cells promote the formation of P. aeruginosa biofilms with a dramatically increased antibiotic resistance. The DeltaF508-CFTR mutation enhances biofilm formation, in part, by increasing Fe release into the apical medium.
The plant ferredoxin precursor: nucleotide sequence of a full length cDNA clone (1985)

A cDNA clone (pFD1) derived from Silene pratensis ferredoxin mRNA was selected from a cDNA-library using the hybrid released translation technique. Nucleotide sequence analysis showed the cDNA insert to contain the complete coding region of the ferredoxin precursor protein. The ferredoxin precursor has a mol.wt. of 15 300, the transit-peptide has a mol.wt. of 5600. The length of the ferredoxin mRNA was found to be 700 nucleotides whereas the cDNA insert was about 1200 basepairs. S1 nuclease protection experiments showed the ferredoxin-specific DNA to be 660 basepairs in length and to start 39 nucleotides upstream of the ferredoxin coding sequence. Southern blot analysis of genomic DNA revealed the presence of only one fragment with homology to the ferredoxin cDNA probe, so it is probably a single-copy gene. Comparison of the ferredoxin transit-sequence with transit sequences of another stromal protein, the small subunit of ribulosebisphosphate carboxylase showed no apparent homology, except for a stretch of three amino acids near the processing site.
Proposal of Mycobacterium peregrinum sp. nov., nom. rev., and Elevation of Mycobacterium chelonae subsp. abscessus (Kubica et al.) to Species Status: Mycobacterium abscessus comb. nov. (1992)

We studied the taxonomic positions of the rapidly growing organism Mycobacterium fortuitum and phenotypically related organisms. We confirmed that "Mycobacterium peregrinum" ATCC 14467T (T = type strain) is genetically independent of M. fortuitum ATCC 6841T by using various DNA hybridization conditions. Strains that were genetically identified as "M. peregrinum" were phenotypically differentiated from M. fortuitum ATCC 6841T. Thus, we propose that "M. peregrinum" should be revived as an independent species, Mycobacterium peregrinum sp. nov., nom. rev. The type strain is strain ATCC 14467. M. fortuitum subsp. acetamidolyticum ATCC 35931T exhibited a high level of DNA relatedness to M. fortuitum ATCC 6841T. The hybridized DNAs maintained stable heteroduplexity at high stringency; thus, we confirmed that M. fortuitum subsp. acetamidolyticum is identical to M. fortuitum ATCC 6841T. We found that M. chelonae subsp. abscessus ATCC 19977T is genetically different from M. chelonae subsp. chelonae NCTC 946T on the basis of the results of quantitative hybridization even under optimal conditions. There was no reason to maintain this organism as a subspecies of M. chelonae. Thus, we propose that M. chelonae subsp. abscessus should be elevated to species status as Mycobacterium abscessus (Kubica et al.) comb. nov. The type strain is strain ATCC 19977.
Formation of arsenic precipitates in GaAs buffer layers grown by molecular beam epitaxy at low substrate temperatures (1990)

We have grown film structures by molecular beam epitaxy which include GaAs buffer layers grown at low substrate temperatures (250 °C). The film structures have been examined using transmission electron microscopy. The layers grown at normal temperatures (600 °C) were free of defects or clusters. In contrast, the layer which was grown at low substrate temperatures contained precipitates which have been identified as hexagonal arsenic. The density of the arsenic precipitates is found to be very sensitive to the substrate temperature during growth.
Methicillin-ResistantStaphylococcus aureusDisease in Three Communities (2005)

Community-associated MRSA infections are now a common and serious problem. These infections usually involve the skin, especially among children, and hospitalization is common.
Expression of Ep-CAM in normal, regenerating, metaplastic, and neoplastic liver (1999)

Ep-CAM is a homophilic, Ca2+-independent cell-cell adhesion molecule that is expressed in many human epithelial tissues. Its increased expression is closely associated with active cell proliferation. Furthermore, in epithelial cell types that in adults lack Ep-CAM (i. e. squamous epithelia), up-regulation of Ep-CAM coincides with the early stages of neoplastic change. This study has analysed the expression of Ep-CAM in liver, in the hepatocytes and cells of the biliary duct system, in relation to proliferative diseases and carcinogenesis. Adult hepatocytes are Ep-CAM negative, with only bile duct epithelium being positive in the liver tissue. However, in the 8-week embryonic liver, the majority of hepatocytes express Ep-CAM. During regeneration and repair of liver tissues associated with focal nodular hyperplasia and (biliary) cirrhosis, activation of Ep-CAM expression was observed, with high expression levels in so-called 'ductular proliferations'-regenerating stem cells. During precursor cell differentiation into mature hepatocytes, several intermediate morphological stages could be observed, all Ep-CAM positive, including cells morphologically close to mature hepatocytes. Full maturation of the precursor resulted in the disappearance of Ep-CAM expression. The results suggest that expression of Ep-CAM is a prerequisite of the proliferative phenotype during differentiation of hepatocyte precursors. In liver neoplasia, Ep-CAM was expressed in almost all cholangiocarcinomas (10/11), whereas the majority of hepatocellular carcinomas (8/10) were negative, suggesting that malignant proliferation of hepatocellular carcinoma cells is not related to expression of Ep-CAM and that hepatocellular carcinoma originates from a highly differentiated precursor. The results indicate that Ep-CAM can be used as an additional immunohistochemical marker to distinguish cholangiocarcinoma from hepatocellular carcinoma due to the differential expression of Ep-CAM in these tumours.
Entre o Lápis e as Carabinas: arte revolucionária e propaganda política nas páginas de Regeneración (2011)

Resumo O Regeneracion foi um jornal fundado em agosto de 1900, pelos irmaos Ricardo e Jesus Flores Magon, na Cidade do Mexico. Em 1905 tornou-se publicacao oficial do Partido Liberal Mexicano (PLM), e, durante o periodo armado da Revolucao Mexicana (1910 – 1920) foi editado na fronteira dos Estados Unidos com o Mexico, ate outubro de 1918. Apesar de ter sido objeto e tema de varias pesquisas, esse artigo pretende trabalhar um aspecto importante, porem pouco pesquisado de Regeneracion: suas charges e ilustracoes politicas. Por meio de uma analise do significado de tais imagens, esse texto tem como objetivo demonstrar que o Regeneracion tambem utilizou a arte como uma forma de propaganda politica, ao criticar os rumos da Revolucao Mexicana e promover o anarquismo como a principal alternativa de governo politico e social. Palavras-chaves: Regeneracion, Imagens politicas, Mexico. Abstract The Regeneracion is a newspaper founded in August 1900, by brothers Jesus and Ricardo Flores Magon, in Mexico City. In 1905 it became the official publication of the Mexican Liberal Party (PLM), and during the violent period of the Mexican Revolution (1910-1920) it was published from the U.S. border with Mexico until October 1918. Despite the fact that Regeneracion has been the object and subject of many academic researches, this article intends to focus on an important aspect of it that is not very studied: its political cartoons and illustrations. Through an analysis of the meaning of such images, this paper aims to demonstrate that Regeneracion used art as a form of political propaganda also, criticizing the way taken by the Mexican Revolution and promoting anarchism as the main alternative for social and political government. Keywords: Regeneracion, Political images, Mexico.