gebhart/patrepeval huggingface dataset:
Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor. (1997)

These data indicate that all of the established and new immunosuppressants tested have antiproliferative properties on vascular cells. Rapamycin was by far the most potent one. Therefore immunosuppressants, especiallyrapamycin and mycophenolic acid, may be used for prevention of accelerated arteriosclerosis.
Two New Rhabdoviruses (Rhabdoviridae) Isolated from Birds During Surveillance for Arboviral Encephalitis, Northeastern United States (2002)

Two novel rhabdoviruses were isolated from birds during surveillance for arboviral encephalitis in the northeastern United States. The first, designated Farmington virus, is a tentative new member of the Vesiculovirus genus. The second, designated Rhode Island virus, is unclassified antigenically, but its ultrastructure and size are more similar to those of some of the plant rhabdoviruses. Both viruses infect birds and mice, as well as monkey kidney cells in culture, but their importance for human health is unknown.
The Effect of Subconjunctivally Injected Hyaluronidase on Corneal Refraction (1969)

Subconjunctivally injected hyaluronidase produced an increase of the corneal curvature accompanied by a corresponding increase of the total ocular refraction up to three diopters in 20 phakic and four aphakic eyes. The change started five to six days after the injection, reached its maximum after about ten days, and lasted for several weeks. No relationship was found between the change in refraction and the change in the ocular fluid dynamics. The possible role of the hyaluronidase sensitive mucopolysaccharides of the cornea and sclera in the realization of the phenomenon is discussed.
A New Relaxation Model for Weighted Graph Matching (2010)

摘要: 图匹配是一个NP难(NP-hard)问题. 基于置换矩阵是非负正交矩阵这一经典结论, 提出赋权图匹配(Weighted graph matching, WGM)的双向松弛障碍规划, 理论上证明新模型的解与原模型的解是一致的. 该规划是一个二元连续规划, 它是正交矩阵上的线性优化问题, 同时也是非负矩阵上的凸二次优化问题. 故设计求解新模型的交替迭代算法, 并证明算法的局部收敛性. 数值实验表明, 在匹配精度方面, 新方法强于线性规划方法和特征值分解方法. 关键词: 图匹配 / 松弛方法 / 置换矩阵 / NP难问题
Effects of atorvastatin and omega-3 fatty acids on LDL subfractions and postprandial hyperlipemia in patients with combined hyperlipemia. (2001)

This study indicates that addition of a low dose of omega-3 FA may further improve the risk profile for CHD in patients with combined hyperlipemia treated with atorvastatin. The effect is related to reduction of postprandial hyperlipemia and redistribution of LDL subfractions.
Genetic Adjuvantation of Recombinant MVA with CD40L Potentiates CD8 T Cell Mediated Immunity (2013)

Modified vaccinia Ankara (MVA) is a safe and promising viral vaccine vector that is currently investigated in several clinical and pre-clinical trials. In contrast to inactivated or sub-unit vaccines, MVA is able to induce strong humoral as well as cellular immune responses. In order to further improve its CD8 T cell inducing capacity, we genetically adjuvanted MVA with the coding sequence of murine CD40L, a member of the tumor necrosis factor superfamily. Immunization of mice with this new vector led to strongly enhanced primary and memory CD8 T cell responses. Concordant with the enhanced CD8 T cell response, we could detect stronger activation of dendritic cells and higher systemic levels of innate cytokines (including IL-12p70) early after immunization. Interestingly, acquisition of memory characteristics (i.e., IL-7R expression) was accelerated after immunization with MVA-CD40L in comparison to non-adjuvanted MVA. Furthermore, the generated cytotoxic T-lymphocytes (CTLs) also showed improved functionality as demonstrated by intracellular cytokine staining and in vivo killing activity. Importantly, the superior CTL response after a single MVA-CD40L immunization was able to protect B cell deficient mice against a fatal infection with ectromelia virus. Taken together, we show that genetic adjuvantation of MVA can change strength, quality, and functionality of innate and adaptive immune responses. These data should facilitate a rational vaccine design with a focus on rapid induction of large numbers of CD8 T cells able to protect against specific diseases.
Effect of Si Doping on Epitaxial Lateral Overgrowth of GaAs on GaAs-Coated Si Substrate (1992)

By adding an impurity, a GaAs(001) facet was successfully formed on the misoriented substrate and epitaxial lateral overgrowth (ELO) of wide area has been achieved. The largest ELO ratio obtained was 15 and in this case, the thickness of the vertical and lateral directions were 10 µm and 150 µm respectively. Molten KOH etching showed that a dislocation-free region was obtained, except in the region above the seed opening. The width of the dislocated region depends on the growth thickness. To obtain a wide dislocation-free region, it is concluded that the vertical growth rate should be suppressed as compared with the lateral growth rate.
Modification of Wiley-Mclaren Tof Analyzers for Laser Desorption (1987)

ABSTRACT Conversion of Wiley-McLaren type TOF instruments for laser desorption is described, including laser optics, timing circuitry, postacceleration detection for high mass and data acquisition. Results are shown to illustrate signal averaging capabilities, detection limits and high mass measurements.
Preparation of partially fluorinated aryl/alkyl vinylene ether polymers (2013)

Abstract A new class of partially fluorinated alternating aryl/alkyl vinylene ether ( FAVE ) polymers were prepared from addition polymerization of aryl trifluorovinyl ethers ( TFVEs ) with 1,4‐butanediol or 4‐hydroxybenzyl alcohol. Monodisperse FAVE telechelic polymers were also prepared possessing latent thermal reactivity which afforded chain‐extended perfluorocyclobutyl ( PFCB ) aryl ethers via step‐growth [2 + 2] cyclodimerization of the aryl TFVEs . Both linear and PFCB chain‐extended FAVE polymers produced thermally robust, optically transparent, flexible spin‐cast films. The FAVE polymers and their telechelic polymers were characterized using 19 F NMR and 1 H NMR complemented with molecular weight analysis using gel permeation chromatography and thermal analysis employing differential scanning calorimetry and thermogravimetry. © 2013 Society of Chemical Industry
Temperature-induced abrupt volume inflation in the mixed-valence ternary Zintl phase Yb8Ge3Sb5 (2005)

The Zintl phase, Yb8Ge3Sb5 exhibits a complex lattice response and an abrupt negative thermal expansion below 15 K - subtle structural changes before and after the transition are consistent with temperature-induced electron transfer from (to) Yb 4f bands to (from) Sb 5p and Ge 4p bands.
ROLE OF C5A IN INFLAMMATORY RESPONSES (2005)

The complement system not only represents an effective innate immune mechanism of host defense to eradicate microbial pathogens, but it is also widely involved in many forms of acute and chronic inflammatory diseases including sepsis, acute lung injury, ischemia-reperfusion injury, and asthma, to give just a few examples. The complement-activated product, C5a, displays powerful biological activities that lead to inflammatory sequelae. C5a is a strong chemoattractant and is involved in the recruitment of inflammatory cells such as neutrophils, eosinophils, monocytes, and T lymphocytes, in activation of phagocytic cells and release of granule-based enzymes and generation of oxidants, all of which may contribute to innate immune functions or tissue damage. Accumulating data suggest that C5a provides a vital bridge between innate and adaptive immune functions, extending the roles of C5a in inflammation. Herein, we review human and animal data describing the cellular and molecular mechanisms of C5a in the development of inflammatory disorders, sepsis, acute lung injury, ischemia-reperfusion injury, and asthma.
CloudVO: Building a Secure Virtual Organization for Multiple Clouds Collaboration (2010)

Cloud computing has become a popular computing paradigm in which virtualized and scalable resources are consolidated to provide services over Internet. However, the resource capability of a single cloud is generally limited, and some applications often require various cloud centers over Internet to deliver services together. Therefore, a Virtual Organization (VO) will be a promising approach to integrate services and users across multiple autonomous clouds. However, how to build a secure virtual organization to achieve the collaboration goals is a critical problem, and some issues such as membership agreement, policy conflict and trust management should be adequately addressed. In this paper, we present a framework CloudVO which based on security policies and trust management techniques to provide some flexible and dynamic VO management protocols for clouds. Therefore, CloudVO can achieve inter-cloud collaboration without destroying a cloud's local policies. Based on previous VO security management experiences, we have conducted some preliminary simulations to verify the effectiveness our approaches for cloud computing environments.
Techniques for wiring in non-square grids (2003)

A systematic approach is presented to wiring layouts in nonsquare grids. The approach involves a combinatorial characterization of layouts that can be wired using, at most, k layers, and using algorithms for obtaining the wiring of a given layout. The algorithms run in time linear with respect to the area occupied by the layout.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An integrated, conditional model of information extraction and coreference with application to citation matching (2004)

Although information extraction and coreference resolution appear together in many applications, most current systems perform them as independent steps. This paper describes an approach to integrated inference for extraction and coreference based on conditionally-trained undirected graphical models. We discuss the advantages of conditional probability training, and of a coreference model structure based on graph partitioning. On a data set of research paper citations, we show significant reduction in error by using extraction uncertainty to improve coreference citation matching accuracy, and using coreference to improve the accuracy of the extracted fields.
Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22 (1999)

CD22 phosphorylation is an early event of B cell antigen receptor engagement and results in the recruitment of the negative regulatory tyrosine phosphatase, SHP-1. Peptides representing the potential phosphorylation sites within the cytoplasmic domain of CD22 have been used to stimulate SHP-1 catalytic activity and to inhibit the binding of SHP-1 to CD22 (Doody, G., Justement, L., Delibrias, C., Matthews, R., Lin, J., Thomas, M., and Fearon, D. (1995) Science 269, 242-244). However, the sites of phosphorylation within the cytoplasmic domain of CD22 and the importance of each for the recruitment and activation of SHP-1 remain unknown. Here we demonstrate that there are multiple sites within the cytoplasmic domain of CD22 that interact with the Src homology 2 domains of SHP-1. Nevertheless, a minimum of two tyrosines in CD22 is required for the association with SHP-1. Furthermore, both Src homology 2 domains of SHP-1 are necessary for efficient binding to CD22.
Coagulation factor XII protease domain crystal structure (2015)

These data provide the first structural basis for understanding FXII substrate recognition and zymogen activation.
The synthesis of 4-cyanoprogesterone: a potent inhibitor of the enzyme 5-α-reductase (1992)

M. Haase-Held, M. Hatzis and J. Mann, J. Chem. Soc., Perkin Trans. 1, 1992, 2999 DOI: 10.1039/P19920002999
Constructing time‐specific reference ranges (1991)

Reference ranges which take time (such as age) into account are often required in medicine, but simple, systematic and efficient statistical methods for constructing them are lacking. A method is described which is based on low order polynomial curves (linear, quadratic or occasionally cubic), together with guidelines for when and how to apply a logarithmic transformation to the variable analysed, testing for departures from normality, and assessment of the adequacy of the reference range which is constructed from the regression line plus or minus a multiple of the standard deviation. Standard statistical packages may be used to carry out the calculations. The question of comparing two or more groups of patients is addressed. Three examples are discussed in detail.
Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression (2009)

Treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic sensitization and improves surrogate markers of disease. Here, we demonstrate a key immunological mechanism, linked epitope suppression, associated with this therapeutic effect. Treatment with selected epitopes from a single allergen resulted in suppression of responses to other ("linked") epitopes within the same molecule. This phenomenon was induced after peptide immunotherapy in human asthmatic subjects and in a novel HLA-DR1 transgenic mouse model of asthma. Tracking of allergen-specific T cells using DR1 tetramers determined that suppression was associated with the induction of interleukin (IL)-10(+) T cells that were more abundant than T cells specific for the single-treatment peptide and was reversed by anti-IL-10 receptor administration. Resolution of airway pathophysiology in this model was associated with reduced recruitment, proliferation, and effector function of allergen-specific Th2 cells. Our results provide, for the first time, in vivo evidence of linked epitope suppression and IL-10 induction in both human allergic disease and a mouse model designed to closely mimic peptide therapy in humans.
Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice (2012)

This study was performed to examine the hepatoprotective effect of isorhamnetin-3-O-galactoside, a flavonoid glycoside isolated from Artemisia capillaris Thunberg (Compositae), against carbon tetrachloride (CCl4)-induced hepatic injury. Mice were treated intraperitoneally with vehicle or isorhamnetin-3-O-galactoside (50, 100, and 200 mg/kg) 30 min before and 2 h after CCl4 (20 μl/kg) injection. Serum aminotransferase activities and hepatic level of malondialdehyde were significantly higher after CCl4 treatment, and these increases were attenuated by isorhamnetin-3-O-galactoside. CCl4 markedly increased serum tumor necrosis factor-α level, which was reduced by isorhamnetin-3-O-galactoside. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase- 2 (COX-2), and heme oxygenase-1 (HO-1) protein and their mRNA expression levels were significantly increased after CCl4 injection. The levels of HO-1 protein and mRNA expression levels were augmented by isorhamnetin-3-O-galactoside, while isorhamnetin- 3-O-galactoside attenuated the increases in iNOS and COX-2 protein and mRNA expression levels. CCl4 increased the level of phosphorylated c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38, and isorhamnetin-3-O-galactoside reduced these increases. The nuclear translocation of nuclear factor kappa B (NF-κB), activating protein-1, and nuclear factor erythroid 2-related factor 2 (Nrf2) were signifi cantly increased after CCl4 administration. Isorhamnetin-3-O-galactoside attenuated the increases of NF-κB and c-Jun nuclear translocation, while it augmented the nuclear level of Nrf2. These results suggest that isorhamnetin-3-O-galactoside ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways.
Genetic map of Salmonella typhimurium, edition VIII. (1995)

We present edition VIII of the genetic map of Salmonella typhimurium LT2. We list a total of 1,159 genes, 1,080 of which have been located on the circular chromosome and 29 of which are on pSLT, the 90-kb plasmid usually found in LT2 lines. The remaining 50 genes are not yet mapped. The coordinate system used in this edition is neither minutes of transfer time in conjugation crosses nor units representing "phage lengths" of DNA of the transducing phage P22, as used in earlier editions, but centisomes and kilobases based on physical analysis of the lengths of DNA segments between genes. Some of these lengths have been determined by digestion of DNA by rare-cutting endonucleases and separation of fragments by pulsed-field gel electrophoresis. Other lengths have been determined by analysis of DNA sequences in GenBank. We have constructed StySeq1, which incorporates all Salmonella DNA sequence data known to us. StySeq1 comprises over 548 kb of nonredundant chromosomal genomic sequences, representing 11.4% of the chromosome, which is estimated to be just over 4,800 kb in length. Most of these sequences were assigned locations on the chromosome, in some cases by analogy with mapped Escherichia coli sequences.
Ruthenium complex catalyzed regioselective dehydrogenation of unsymmetrical .alpha.,.omega.-diols (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRuthenium complex catalyzed regioselective dehydrogenation of unsymmetrical .alpha.,.omega.-diolsYouichi Ishii, Kohtaro Osakada, Takao Ikariya, Masahiko Saburi, and Sadao YoshikawaCite this: J. Org. Chem. 1986, 51, 11, 2034–2039Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00361a018https://doi.org/10.1021/jo00361a018research-articleACS PublicationsRequest reuse permissionsArticle Views905Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Engineered therapeutic antibodies with improved effector functions (2009)

In the past decade, more than 20 therapeutic antibodies have been approved for clinical use and many others are now at the clinical and preclinical stage of development. Fragment crystallizable (Fc)-dependent antibody functions, such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and a long half-life, have been suggested as important clinical mechanisms of therapeutic antibodies. These functions are primarily triggered through direct interaction of the Fc domain with its corresponding receptors: FcgammaRIIIa for ADCC, C1q for CDC, and neonatal Fc receptor for prolongation of the clearance rate. However, current antibody therapy still faces the critical issues of insufficient efficacy and the high cost of the therapeutic agents. A possible solution to these issues could be to engineer antibody molecules to enhance their antitumor activity, leading to improved therapeutic outcomes and reduced doses. Here, we review advanced Fc engineering approaches for the enhancement of effector functions, some of which are now ready for evaluation of their effectiveness in clinical trials.
Gap junction connexon configuration in rapidly frozen myocardium and isolated intercalated disks. (1984)

By using two ultrarapid freezing techniques, we have captured the structure of rat and rabbit cardiac gap junctions in a condition closer to that existing in vivo than to that previously achieved. Our results, which include those from fully functional hearts frozen in situ in the living animal, show that the junctions characteristically consist of multiple small hexagonal arrays of connexons. In tissue frozen 10 min after animal death, however, unordered arrays are common. Examination of junction structure at intervals up to 40 min after death reveals a variety of configurations including dispersed and close-packed unordered arrays, and hexagonal arrays. By use of an isolated intercalated disk preparation, we show that the configuration of cardiac gap junctions in vitro cannot be altered by factors normally considered to induce functional uncoupling. These experiments demonstrate that, contrary to the conclusions of some earlier studies (Baldwin, K. M., 1979, J. Cell Biol., 82:66-75; Peracchia, C., and L. L. Peracchia, 1980, J. Cell Biol., 87:708-718), the arrangement of gap junction connexons, in cardiac tissue at least, cannot be used as a reliable guide to the functional state of the junctions.
Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type (1989)

Transforming growth factor-beta (TGF beta 1 and TGF beta 2) bind to several different cell surface proteins, including a high Mr proteoglycan. We found that on primary and early passage cultures of fibroblasts, chondroblasts, and osteoblasts TGF beta 1 binds to both the high Mr proteoglycan and to lower Mr components, whereas on epithelial, endothelial, and lymphoid-derived cells TGF beta 1 only binds to the lower Mr species. With cell lines, this distinction is lost. Further analysis indicated that binding to the high Mr proteoglycan is not necessary for TGF beta 1 induced regulation of DNA, collagen and fibronectin synthesis, change in cell morphology, or reorganization of the actin cytoskeleton. We propose that the lower Mr components are the active receptors mediating these events.
Perception, Planning and Control for Self-Driving System Based on On-board Sensors (2014)

The autonomous vehicle can recognize and understand environment, self-control, and achieve the driving level of the human driver. To create this kind of system, the following work was carried out: (a) a real time lane detection system is proposed, based on vision system functions, using webcam camera; (b) In order to detect curve lanes, deep learning is applied for lane detection, based on fully Convolutional Neural Network (CNN); (c) The cubic spline interpolation method is used for path generation, based on Global Positioning System (GPS) data, where distance between two adjacent path generation points is same. Compared with the connection method of the cubic polynomial fitting algorithm, the curve fitted path by the cubic spline interpolation method is smoother and more satisfied with the vehicle motion pattern; (d) Based on frenet coordinate frame, optimize trajectory planning method is used to plan safe, easy and comfort trajectory. Compared to the Cartesian coordinate frame, frenet coordinate frame simplifies the solution of road curve fitting problems, especially in the case of complex road environment; (e) Fuzzy sliding mode control method is proposed for vehicle steering control. Finally, the simulation and experiment results are used to prove the effectiveness of the proposed methods.