gebhart/patrepeval huggingface dataset:
Photodynamic Therapy Enhancement of Antitumor Immunity Is Regulated by Neutrophils (2007)

Photodynamic therapy (PDT) is a Food and Drug Administration-approved local cancer treatment that can be curative of early disease and palliative in advanced disease. PDT of murine tumors results in regimen-dependent induction of an acute local inflammatory reaction, characterized in part by rapid neutrophil infiltration into the treated tumor bed. In this study, we show that a PDT regimen that induced a high level of neutrophilic infiltrate generated tumor-specific primary and memory CD8(+) T-cell responses. In contrast, immune cells isolated from mice treated with a PDT regimen that induced little or no neutrophilic infiltrate exhibited minimal antitumor immunity. Mice defective in neutrophil homing to peripheral tissues (CXCR2(-/-) mice) or mice depleted of neutrophils were unable to mount strong antitumor CD8(+) T-cell responses following PDT. Neutrophils seemed to be directly affecting T-cell proliferation and/or survival rather than dendritic cell maturation or T-cell migration. These novel findings indicate that by augmenting T-cell proliferation and/or survival, tumor-infiltrating neutrophils play an essential role in establishment of antitumor immunity following PDT. Furthermore, our results may suggest a mechanism by which neutrophils might affect antitumor immunity following other inflammation-inducing cancer therapies. Our findings lay the foundation for the rational design of PDT regimens that lead to optimal enhancement of antitumor immunity in a clinical setting. Immune-enhancing PDT regimens may then be combined with treatments that result in optimal ablation of primary tumors, thus inhibiting growth of primary tumor and controlling disseminated disease.
Trellis-searched adaptive predictive coding (2003)

Considers the use of TCO (trellis coded quantization) in an adaptive predictive coding (APC) structure at encoding rates slightly above one and two bits per sample. The authors examine the effect of long- and short-term predictor order on the encoding performance and study the variation in performance as a function of the TCQ codebook. The simulation results indicate that SNRs (signal/noise ratio) and SEGSNRs (segmental SNRs) as high as 25 and 24 dB, respectively, are possible at rates slightly above two bits per sample using a simple four-state trellis. At higher near one bit per sample, SNRs and SEGNRs as high as 16.5 and 15.5 dB, respectively, are possible.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Acoustic Measurements Using a Fiber Optic Sensor System (2003)

Recent work conducted on developing a fiber tip based Fabry-Perot (FTFP) sensor system for acoustic measurements is presented in this article. It has been determined that this system can be used to detect acoustic fields in the frequency range of 20 Hz-6 kHz with an optical phase sensitivity of 0.095 rad/Pa. A series of experiments is performed to investigate the possibility and potential use of this sensor system, which is designed to be implemented in a multiplexed architecture for providing response measurements to a structural acoustic control system.
Virtual Frameworks—Modeling Data Dynamically (2002)

A universal truth of any solution is that the data model describing the user’s storage and retrieval activity is perhaps the most application-centric of any construct in the developer’s domain. At the elemental level, the developer must wire access to specific database columns (such as price, quantity, markup, and cost). A screen developer must gain access to these elements and present them to the user, effectively creating an interactive relationship between specific database columns and their corresponding on-screen entry points (drop-downs, grids, text boxes, etc.).
Modeling, analysis, simulation, scheduling, and control of semiconductor manufacturing systems: A Petri net approach (1998)

This paper presents a Petri net approach to modeling, analysis, simulation, scheduling, and control of semiconductor manufacturing systems. These systems can be characterized as discrete event systems that exhibit sequential, concurrent, and conflicting relations among the events and operations. Their evolution is dynamic over time. The system complexity is tremendous owing to the complex semiconductor manufacturing processes and test procedures. A formal approach such as Petri nets enables one to describe such complex discrete event systems precisely and thus allows one to perform both qualitative and quantitative analysis, scheduling and discrete-event control of them. This paper also serves as a tutorial paper. It briefly reviews applications of Petri nets in semiconductor manufacturing automation. It then introduces definitions and concepts of Petri nets. It proceeds with a discussion of basic Petri net modules in system modeling, a modeling method and a practical system's modeling example. Next, the paper presents their properties and their implications in manufacturing systems, as well as their analysis methods. Timed Petri nets are introduced for system simulation, performance evaluation, and scheduling purposes. An application-oriented case study is presented. Finally, the paper concludes with the active research areas in applying Petri nets to design of semiconductor manufacturing systems.
Treatment of recurrent malignant gliomas with high-dose 13-cis-retinoic acid. (1996)

Malignant gliomas account for more than 60% of all primary brain tumors in adults. Adjuvant chemotherapy in addition to radical surgery and radiation therapy has provided only a modest increase in survival. Retinoic acid has been shown to have growth-inhibitory activity against glioma cells in culture. This provides the rationale for a Phase II study using 13-cis-retinoic acid (CRA) in patients with recurrent malignant brain tumors. The objective of this study was to determine the clinical activity of CRA in patients with a histologically proven diagnosis of malignant brain tumor and documented progressive or recurrent disease after radiation and chemotherapy. Fifty patients with documented recurrent disease were treated with CRA as a single agent p.o. at a dose of 60-100 mg/m2 per day. Three weeks of treatment were followed by 1 week of rest. Of the 43 patients who received more than 4 weeks of therapy, 3 (7%) achieved partial response, 7 (16%) achieved minor response, 13 (30%) remained stable, and 20 (47%) had disease progression. The median time from onset of treatment to disease progression for the whole group of 43 patients was 16 weeks (19 weeks for glioblastomas and 11 weeks for anaplastic glioma), whereas that for the 23 patients with partial response and minor response and who remained stable was 66 weeks, and that for the 20 patients with progressive disease was only 8 weeks. The median survival time for glioblastoma was 58 weeks, and 34 weeks for anaplastic astrocytoma. Toxicity was mainly dermatological, with dry skin and cheilitis. These preliminary results suggest that 13-cis-retinoic acid is active against malignant gliomas and is very well tolerated.
A net-based approach to coordination polymers † (2000)

True crystal engineering of coordination polymers with useful structure-based properties by design remains a distant prospect. The exploratory, experimental net-based approach to the construction of coordination polymers described in this article has provided a few examples of structures obtained by design, but also serendipitously revealed numbers of unprecedented and interesting structures that were totally unexpected. Further work with coordination polymers can confidently be expected to provide many similar surprises. It is proposed that carefully designed connecting ligands capable of binding metal centres strongly and predictably at chelating sites may afford improved structural control in network assembly and more robust network structures.
Hepatocyte proliferation and alpha 1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats. (1974)

Serum α1-fetoprotein concentrations of pregnant and newborn rats and of rats following partial hepatectomy have been measured by radioimmunoassay, and the results have been correlated to the numbers of hepatocytes synthesizing DNA. Rising concentrations follow rounds of hepatocellular proliferation indicating that the production of α1-fetoprotein is closely coupled to cellular division, i.e. , either α1-fetoprotein is synthesized transiently and released by a postmitotic cell or it is synthesized prior to mitosis and released after mitosis.
Four years of post‐genomic life with 6000 yeast genes (2000)

Four years after disclosure of the full yeast genome sequence, a series of resources including tens of thousands of mutant strains, plasmids bearing isolated genes and disruption cassettes are becoming publicly available. Deletions of each of the 6,000 putative yeast genes are being screened systematically for dozens of phenotypic traits. In addition, new global approaches such as DNA hybridization arrays, quantitative proteomics and two-hybrid interactions are being steadily improved. They progressively build up an immense computation network of billions of data points which will, within the next decade, characterize all molecular interactions occurring in a simple eukaryotic cell. In this process of acquisition of new basic knowledge, an international community of over 1,000 laboratories cooperates with a remarkable willingness to share projects and results.
An Electrochemical Sensor Based on Nanostructured Hollandite-type Manganese Oxide for Detection of Potassium Ions (2009)

The participation of cations in redox reactions of manganese oxides provides an opportunity for development of chemical sensors for non-electroactive ions. A sensor based on a nanostructured hollandite-type manganese oxide was investigated for voltammetric detection of potassium ions. The detection is based on the measurement of anodic current generated by oxidation of Mn(III) to Mn(IV) at the surface of the electrode and the subsequent extraction of the potassium ions into the hollandite structure. In this work, an amperometric procedure at an operating potential of 0.80 V (versus SCE) is exploited for amperometric monitoring. The current signals are linearly proportional to potassium ion concentration in the range 4.97 × 10(-5) to 9.05 × 10(-4) mol L(-1), with a correlation coefficient of 0.9997.
Evaluation of serum eosinophil cationic protein as a predictive marker for asthma exacerbation in patients with persistent disease (2002)

Our findings suggest that serum ECP may be used to predict a response to corticosteroid therapy in adult patients with asthma.
Comprehensive assessment of automatic structural alignment against a manual standard, the scop classification of proteins (1998)

We apply a simple method for aligning protein sequences on the basis of a 3D structure, on a large scale, to the proteins in the scop classification of fold families. This allows us to assess, understand, and improve our automatic method against an objective, manually derived standard, a type of comprehensive evaluation that has not yet been possible for other structural alignment algorithms. Our basic approach directly matches the backbones of two structures, using repeated cycles of dynamic programming and least-squares fitting to determine an alignment minimizing coordinate difference. Because of simplicity, our method can be readily modified to take into account additional features of protein structure such as the orientation of side chains or the location-dependent cost of opening a gap. Our basic method, augmented by such modifications, can find reasonable alignments for all but 1.5% of the known structural similarities in scop, i.e., all but 32 of the 2,107 superfamily pairs. We discuss the specific protein structural features that make these 32 pairs so difficult to align and show how our procedure effectively partitions the relationships in scop into different categories, depending on what aspects of protein structure are involved (e.g., depending on whether or not consideration of side-chain orientation is necessary for proper alignment). We also show how our pairwise alignment procedure can be extended to generate a multiple alignment for a group of related structures. We have compared these alignments in detail with corresponding manual ones culled from the literature. We find good agreement (to within 95% for the core regions), and detailed comparison highlights how particular protein structural features (such as certain strands) are problematical to align, giving somewhat ambiguous results. With these improvements and systematic tests, our procedure should be useful for the development of scop and the future classification of protein folds.
Contemporary Concepts of the Pathogenesis and Management of Preeclampsia (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes (2017)

Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170-4182, 2017. © 2017 Wiley Periodicals, Inc.
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. (1985)

An enzyme from bovine liver microsomes that catalyzes the reduction of vitamin K 2,3-epoxide to 2- and 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone was purified 1152-fold to apparent homogeneity. Microsomes were solubilized with 3-[3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS), and the enzyme was purified by chromatography on PBE-94 ion exchanger, hydroxylapatite, and DEAE-cellulose, and then gel filtration on Sephacryl S-200. The homogeneity of the final preparation was established by polyacrylamide slab gel electrophoresis in the presence of sodium dodecyl sulfate. The molecular weight of the native enzyme is 25,000 and that of denatured enzyme is 12,400, which suggests that the enzyme is a dimer with identical subunits. No chromophoric cofactors are associated with the enzyme. Dithiothreitol and CHAPS are essential for activity, but high concentrations of glycerol reduces the activity. The enzyme is not inhibited by warfarin, a potent inhibitor of the vitamin K epoxide reductase, which catalyzes the conversion of vitamin K 2,3-epoxide to vitamin K. Evidence is presented indicating that the purified enzyme is not simply a fragment of the warfarin-sensitive vitamin K epoxide reductase.
Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing (2017)

Androgen signals through androgen receptor (AR) to influence prostate development and cancer. How stromal and epithelial AR regulate prostate homeostasis remains unclear. Using genetic lineage tracing, we systematically investigated the role of cell-autonomous AR in different prostate epithelial cell types. Here we show that AR is dispensable for basal cell maintenance, but is cell-autonomously required for the luminal differentiation of rare basal stem cells. In contrast, AR deletion in luminal cells alters cell morphology and induces transient over-proliferation, without affecting androgen-mediated luminal cell survival or regeneration. However, AR is selectively required for the maintenance of daughter cells produced by castration-resistant Nkx3.1-expressing luminal stem cells (CARNs). Notably, Pten loss can override AR-loss effects in both basal and luminal compartments to initiate tumours. Our data reveal distinct cell-type-specific roles of epithelial AR in orchestrating prostate homeostasis, and question the notion that epithelial AR serves as a tumour suppressor in early cancer initiation.
Intercalation of Organic Ammonium Ions into Layered Graphite Oxide (2002)

The intercalation of large organic ammonium ions (tetramethylammonium ions (TMA+), tetraethylammonium ions (TEA+), tetrapropylammonium ions (TPA+), and tetrabutylammonium ions (TBA+)) into layered graphite oxide (GO) was systematically investigated. The intercalation reactions were completed at 25 °C after 3 days, and stable colloidal suspensions were obtained at TAAl/Hs = 5 (molar ratio of tetraalkylammonium ions (TAA+) over exchangeable protons in GO). The sediments after centrifuging the colloidal suspensions showed amorphous phase X-ray diffraction patterns, indicating that exfoliation of the layered structure into nanosheets took place in the suspension. When the sediments were dried at 70 °C for 3 days, layered structures of TAA+-intercalated GO materials with basal spacings of 1.56, 1.67, 1.84, and 2.37 nm, respectively, appeared. The basal spacing of the layered compounds decreased with a decrease of relative humidity during drying. When the dried TAA+-intercalated GO compounds were exposed to a humid saturated atmosphere, the basal spacing increased gradually, finally becoming an amorphous structure. The maximum saturation of intercalated TAA+ ions into GO decreased with the increase in alkyl chain length. When the TAA+-intercalated materials were washed with distilled water and acid-treated, a process of deintercalation of TAA+ ions from the interlayer occurred. A schematic model for the deintercalation−intercalation involving a exfoliation process is proposed. The layered structure of TAA+-intercalated GO materials is discussed in terms of the dimension of the GO layer and the sizes of H2O molecules and TAA+ ions.
On the capacity achieving covariance matrix for frequency selective MIMO channels using the asymptotic approach (2010)

In this contribution, an algorithm for evaluating the capacity-achieving input covariance matrices for frequency selective Rayleigh MIMO channels is proposed. In contrast with the flat fading Rayleigh cases, no closed-form expressions for the eigenvectors of the optimum input covariance matrix are available. Classically, both the eigenvectors and eigenvalues are computed numerically and the corresponding optimization algorithms remain computationally very demanding. In this paper, it is proposed to optimize (w.r.t. the input covariance matrix) a large system approximation of the average mutual information derived by Moustakas and Simon. An algorithm based on an iterative water filling scheme is proposed, and its convergence is studied. Numerical simulation results show that, even for a moderate number of transmit and receive antennas, the new approach provides the same results as direct maximization approaches of the average mutual information.
Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage. (1989)

To investigate the regulation of expression of cardiac Ca2" + Mg2+-dependent ATPase (Ca2+-ATPase) in sarcoplasmic reticulum (SR), we isolated cDNA (pHA6) encoding a Ca2+- ATPase of rat cardiac SR. The clone consisted of 2,311 mRNA-derived nucleotides, which covered half the coding re- gion and the entire 3'-untranslated regions. The nucleotides and deduced amino acid sequences of pHA6 showed striking homology, 89 and 98%, respectively, to those of rabbit Ca +- ATPase of the slow-twitch form. Northern blot analyses re- vealed that the mRNA levels of Ca2`-ATPase were decreased by pressure overload and became 32% of sham in 1 mo. During the developmental stage the mRNA levels were very low in the fetal period and steeply increased around birth. These changes in mRNA levels were correlated with the corresponding pro- tein levels. These results suggest that the expression of cardiac Ca2+-ATPase in SR is regulated by pressure overload and the developmental stage, at least in part, at the pretranslational level.
Quantification of Human Cytomegalovirus DNA by Real-Time PCR (2001)

A quantitative real-time PCR assay was developed to measure human cytomegalovirus (HCMV) DNA load in peripheral blood leukocytes (PBLs). The HCMV DNA load in PBLs was normalized by means of the quantification of a cellular gene (albumin). The results of the real-time PCR assay correlated with those of the HCMV pp65-antigenemia assay (P < 0.0001).
Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients (1999)

The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether a cytokine imbalance oriented toward Th2 type response plays a role in chronic hepatitis B. Cytokine profiles of peripheral blood mononuclear cells associated with chronic hepatitis B were analysed by RT-PCR. Upon HBsAg stimulation, expression of IFN-gamma, IL-2, IL-4, and IL-10 was detected in 41%, 8%, 41%, and 50% of the patients, respectively. Among these cytokines, the expression of IFN-gamma was associated with high levels of serum AST/ALT. However, we could not prove that Th2 type cytokines had a protective effect on hepatocytes. Upon HBxAg stimulation, there was no recognizable association of cytokine patterns with AST/ALT levels. In conclusion, production of a Th1 cytokine, IFN-gamma, by HBsAg-reactive cells was associated with hepatocyte damage in chronic hepatitis B, while no counteracting effect of Th2 cytokines produced by those cells was observed.
Toward an optical synthesizer: a single-frequency parametric oscillator using periodically poled LiNbO_3 (1997)

We demonstrate single-frequency operation of a cw quasi-phase-matched singly resonant optical parametric oscillator (SRO). We obtained widely tunable output from 1.66 to 1.99 mum (signal) and from 2.29 to 2.96 mum (idler) by employing a periodically poled lithium niobate multigrating chip. Using a single-frequency miniature Nd:YAG ring laser as a pump source results in SRO output with high spectral purity and frequency stability(<10 MHz/min), which can be continuously tuned over 2 GHz without mode hops. We obtain a minimum SRO threshold of 260mW by resonating the pump wave in the SRO cavity.