gebhart/patrepeval huggingface dataset:
Immunoreactivity for cyclin D3 is frequently detectable in high‐grade primary gastric lymphomas in the absence of the t(6;14)(p21.1;q32.3) chromosomal translocation (2003)

Cyclin D3 plays a pivotal role in controlling the physiological progression from the G1 to the S phase of the cell cycle. Recent data suggest that cyclin D3 may be deregulated in extranodal non-Hodgkin's lymphomas (NHLs) as a consequence of the t(6;14)(p21.1;q32.3) translocation. The present study investigated for the first time by dual-colour fluorescence in situ hybridization (FISH) on interphase nuclei and immunohistochemistry the prevalence of the t(6;14) translocation and cyclin D3 immunoreactivity (IR) in a series of 29 stage I-IIE primary gastric NHLs (PGLs). No case showed the t(6;14) translocation. However, in five (17.2%) cases (two extranodal marginal zone lymphomas of MALT type, LGM; one diffuse large-cell lymphoma with a MALT component, DLCLM; and two diffuse large-cell lymphomas without a MALT component, DLCL), three to four cyclin D3 signals were detected by FISH. Co-hybridization with probes specific for the centromeric region and long arm of chromosome 6 indicated trisomy in one case (DLCL), whereas in the remaining four cases the pattern was highly suggestive of the presence of an isochromosome 6p. One (12.5%) case of LGM, six (75%) cases of DLCLM, and seven (53.8%) cases of DLCL (p = 0.0378) were immunoreactive for cyclin D3. Cyclin D3 IR was detected in two (40%) of the five cases with extra cyclin D3 signals and in 12 of the remaining 24 cases (50%, p = 1.000). These results suggest that the t(6;14) may represent a rare event in the pathogenesis of PGL and that cyclin D3 deregulation is most likely the result of epigenetic mechanisms.
New mosquito repellent from Eucalyptus camaldulensis (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew mosquito repellent from Eucalyptus camaldulensisKeisuke. Watanabe, Yoshinori. Shono, Akiko. Kakimizu, Akihiko. Okada, Noritada. Matsuo, Atsushi. Satoh, and Hiroyuki. NishimuraCite this: J. Agric. Food Chem. 1993, 41, 11, 2164–2166Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jf00035a065https://doi.org/10.1021/jf00035a065research-articleACS PublicationsRequest reuse permissionsArticle Views665Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Acute olfactory response of Culex mosquitoes to a human- and bird-derived attractant (2009)

West Nile virus, which is transmitted by Culex mosquitoes while feeding on birds and humans, has emerged as the dominant vector borne disease in North America. We have identified natural compounds from humans and birds, which are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of Culex pipiens quinquefasciatus (Cx. quinquefasciatus). One of these semiochemicals, nonanal, dominates the odorant spectrum of pigeons, chickens, and humans from various ethnic backgrounds. We determined the specificity and sensitivity of all ORN types housed in different sensilla types on Cx. quinquefasciatus antennae. Here, we present a comprehensive map of all antennal ORNs coding natural ligands and their dose-response functions. Nonanal is detected by a large array of sensilla and is by far the most potent stimulus; thus, supporting the assumption that Cx. quinquefasciatus can smell humans and birds. Nonanal and CO(2) synergize, thus, leading to significantly higher catches of Culex mosquitoes in traps baited with binary than in those with individual lures.
Design of Highly Active Binary Catalyst Systems for CO2/Epoxide Copolymerization:  Polymer Selectivity, Enantioselectivity, and Stereochemistry Control (2006)

Asymmetric, regio- and stereoselective alternating copolymerization of CO(2) and racemic aliphatic epoxides proceeds effectively under mild temperature and pressure by using a binary catalyst system of a chiral tetradentate Schiff base cobalt complex [SalenCo(III)X] as the electrophile in conjunction with an ionic organic ammonium salt or a sterically hindered strong organic base as the nucleophile. The substituent groups on the aromatic rings, chiral diamine backbone, and axial X group of the electrophile, as well as the nucleophilicity, leaving ability, and coordination ability of the nucleophile, all significantly affect the catalyst activity, polymer selectivity, enantioselectivity, and stereochemistry. A bulky chiral cyclohexenediimine backbone complex [SalcyCo(III)X] with an axial X group of poor leaving ability as the electrophile, combined with a bulky nuclephile with poor leaving ability and low coordination ability, is an ideal binary catalyst system for the copolymerization of CO(2) and a racemic aliphatic epoxide to selectively produce polycarbonates with relatively high enantioselectivity, >95% head-to-tail connectivity, and >99% carbonate linkages. A fast copolymerization of CO(2) and epoxides was observed when the concentration of the electrophile or/and the nucleophile was increased, and the number of polycarbonate chains was proportional to the concentration of the nucleophile. Electrospray ionization mass spectrometry, in combination with a kinetic study, showed that the copolymerization involved the coordination activation of the monomer by the electrophile and polymer chain growth predominately occurring in the nucleophile. Both the enantiomorphic site effect resulting from the chiral electrophile and the polymer chain end effect mainly from the bulky nucleophile cooperatively control the stereochemistry of the CO(2)/epoxide copolymerization.
THEORETICAL ANALYSIS OF THE SENSITIVITY OF A CORIOLIS MASS FLOW METER (2003)

A Πshape pipe model which has the same mass as the U shape pipe in the Coriolis mass flow\|meter sensor is proposed and analyzed.Using the principle of the Coriolis force to illustratie the gyro motion together with the theory of elastic deformation for a cantilever beam we have derived a computational formula of sensitivity that has been verified by actual experiment.
Rheological and DSC changes in poly(vinyl alcohol) gels induced by immersion in water (1985)

Abstract Poly(vinyl alcohol) (PVA) gels were prepared by freezing and thawing aqueous solutions at temperatures from −20 to 15°C. The temperature was varied periodically by use of a computer. The endothermic DSC peak was observed for the PVA gels at about 60°C for five specimens of different degrees of saponification (DS). Another endothermic peak was also observed in the range 67–80°C, and this peak shifted to higher temperature with increasing DS. These endothermic peaks shifted to lower temperature on immersion of the PVA gels in water. The dynamic Young's modulus E ′ at room temperature was also decreased by immersion of PVA gels in water; E ′ decreased monotonically with increasing temperature for PVA gels without immersion in water, while it increased up to a certain temperature and then decreased with increasing temperature for PVA gels in water. The X‐ray diffraction showed a characteristic crystalline pattern for PVA gels of higher DS, and this peak was intensified by stretching the gel.
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease (2012)

Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD); however, the relationship between NFTs and disease progression remains controversial. Analyses of tau animal models suggest that phenotypes coincide with accumulation of soluble aggregated tau species but not the accumulation of NFTs. The pathological role of prefilamentous tau aggregates, e.g., tau oligomeric intermediates, is poorly understood, in part because of methodological challenges. Here, we engineered a novel tau oligomer-specific antibody, T22, and used it to elucidate the temporal course and biochemical features of oligomers during NFT development in AD brain. We found that tau oligomers in human AD brain samples were 4-fold higher than those in the controls. We also revealed the role of oligomeric tau conformers in pretangles, neuritic plaques, and neuropil threads in the frontal cortex tissue from AD brains; this analysis uncovers a consistent code that governs tau oligomerization with regard to degree of neuronal cytopathology. These data are the first to characterize the role of tau oligomers in the natural history of NFTs, and they highlight the suitability of tau oligomers as therapeutic targets in AD and related tauopathies.
Selective Growth, In Vitro and In Vivo, of Individual T Cell Clones from Tumor-Infiltrating Lymphocytes Obtained from Patients with Melanoma (2004)

In recent clinical trials in patients with metastatic melanoma, adoptive transfer of tumor-reactive lymphocytes mediated the regression of metastatic tumor deposits. To better understand the role of individual T cell clones in mediating tumor regression, a 5' RACE technique was used to determine the distribution of TCR beta-chain V region sequences expressed in the transferred cells as well as in tumor samples and circulating lymphocytes from melanoma patients following adoptive cell transfer. We found that dominant T cell clones were present in the in vitro-expanded and transferred tumor-infiltrating lymphocyte samples and certain T cell clones including the dominant T cell clones persisted at relatively high levels in the peripheral blood of the patients that demonstrated clinical responses to adoptive immunotherapy. However, these dominant clones were either undetected or present at a very low level in the resected tumor samples used for tumor-infiltrating lymphocyte generation. These data demonstrated that there was selective growth and survival, both in vitro and in vivo, of individual T cell clones from a relatively small number of T cells in the original tumor samples. These results suggest that the persistent T cell clones played an active role in mediating tumor regression and that 5' RACE analysis may provide an important tool for the analysis of the role of individual T cell clones in mediating tumor regression. A similar analysis may also be useful for monitoring autoimmune responses.
Nephrocystin-conserved Domains Involved in Targeting to Epithelial Cell-Cell Junctions, Interaction with Filamins, and Establishing Cell Polarity (2002)

Nephrocystin is the protein product of the gene mutated in juvenile nephronophthisis, an autosomal recessive cystic kidney disease afflicting children and young adults. Because the normal cellular function of nephrocystin is largely unknown, the molecular defects underlying disease pathogenesis remain obscure. Analysis of nephrocystin amino acid sequences from human and other species revealed three distinct conserved domains including Src homology 3 and coil-coil domains in the N-terminal region, as well as a large highly conserved C-terminal region bearing no obvious homology to other proteins and hence referred to as the "nephrocystin homology domain" (NHD). The objective of this study was to gain insight into nephrocystin function by defining functional properties of the conserved domains. We analyzed a series of nephrocystin deletion mutants expressed in Madin-Darby canine kidney and COS-7 cells. This analysis revealed previously unrecognized functional attributes of the NHD, including abilities to promote both self-association and epithelial cell-cell junctional targeting. We further observed that Madin-Darby canine kidney cell lines stably expressing a nephrocystin mutant with a deletion of the Src homology 3 domain have reduced ability to establish tight junctions as measured by transepithelial electrical resistance. Finally, from a two-hybrid screen and coimmunoprecipitation studies we identified members of the filamin family of actin-binding proteins as having the capacity to interact with the NHD. These findings support a functional role for nephrocystin as a docking protein involved in organizing a protein complex to regulate the actin cytoskeleton at sites of epithelial cell-cell adhesion and further suggest that these properties are important for establishing epithelial cell polarity.
A New Approach to High-Capacity Digital Mobile Radio (1981)

Space diversity (adaptive phased-array antennas) is an effective weapon against the cochannel interference encountered in cellular mobile radio systems. High-order diversity, and hence, strong interference suppression, can be achieved with modest hardware complexity by using time-division retransmission. With this technique, which is especially well-suited to digital modulation methods, the adaptive signal processing required for space diversity can be performed at just one end of the communication link, namely, the base station. At the other end (the mobile unit) only a single-element antenna is needed. Moreover, the use of coherent phase-shift keying in such a system allows simple RF circuity, because the adaptive processing is done at baseband. In the context of cellular mobile radio, the combination of space diversity, time-division retransmission and 120-degree corner illumination of each cell can yield a reliable communication channel even in the presence of intercell interference, Ray leigh fading (both flat and frequency-selective), and shadow fading. The use of these techniques allows approximately 130 two-way channels per cell (at 32 kb/s each) to be accommodated in the 40-MHz bandwidth of the 850-MHz mobile radio band.
The Protective Effect of Vasoactive Intestinal Peptide (VIP) on Stress‐Induced Gastric Ulceration in Rats (1998)

A bstract : The pathogenesis of cold‐restraint stress ulcer involves various factors and is not completely understood. Mast cell degranulation, increased gastric muscular contractility, diminished mucosal blood flow, release of several biogenic amines, activated polymorphonuclear leukocytes, and lipid peroxidation which results from toxic oxygen molecules were suggested to be related to the production of gastric damage by cold‐restraint stress. Recent evidence strongly indicates that VIP has a modulatory effect on tissue injury. Sprague‐Dawley rats were used in two series of experiments. One set of rats was exposed to cold‐restraint stress with some of the rats pretreated with VIP. The second set of rats was exposed to cold‐restraint stress and then was administered VIP for different durations. Cold‐restraint stress induced gastric lesions and mast cell degranulation and also increased lipid peroxidation in gastric tissue. VIP prevented stress‐induced ulcers and mast cell degranulation and protected gastric tissue from lipid peroxidation. When VIP was used after induction of stress ulcer it was therapeutically beneficial. Thanks to its antioxidant and anti‐inflammatory activity, VIP can be valuable in the prevention of gastric mucosal damage induced by cold‐restraint stress.
Removal of formyl, acetyl, and benzoyl groups from amides with conversion into the corresponding t-butyl carbamates (1985)

N-Formyl, -acetyl, and -benzoyl groups can be removed from secondary amides with amines under mild conditions after t-butoxycarbonylation, giving acid-labile t-butyl carbamates.
Video Streaming: Concepts, Algorithms, and Systems (2003)

video streaming, video delivery, streaming media content delivery networks, video coding, errorresilient; multiple description coding Video has been an important media for communications and entertainment for many decades. Initially video was captured and transmitted in analog form. The advent of digital integrated circuits and computers led to the digitization of video, and digital video enabled a revolution in the compression and communication of video. Video compression became an important area of research in the late 1980’s and 1990’s and enabled a variety of applications including video storage on DVD’s and Video-CD’s, video broadcast over digital cable, satellite and terrestrial (over-the-air) digital television (DTV), and video conferencing and videophone over circuit-switched networks. The growth and popularity of the Internet in the mid-1990’s motivated video communication over best-effort packet networks. Video over best-effort packet networks is complicated by a number of factors including unknown and time-varying bandwidth, delay, and losses, as well as many additional issues such as how to fairly share the network resources amongst many flows and how to efficiently perform one-to-many communication for popular content. This article examines the challenges that make simultaneous delivery and playback, or streaming, of video difficult, and explores algorithms and systems that enable streaming of pre-encoded or live video over packet networks such as the Internet.
Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo (2017)

High-resolution imaging of the human retina has always been a challenge due to imperfect optical properties of the human cornea and lens, which limit the achievable resolution. We present a noniterative digital aberration correction (DAC) to achieve aberration-free cellular-level resolution in optical coherence tomography (OCT) images of the human retina in vivo. The system used is a line-field spectral-domain OCT system with a high tomogram rate, reaching 2.5 kHz. Such a high speed enables us to successfully apply digital aberration correction for not only imaging of human cone photoreceptors but also to obtain an aberration- and defocus-corrected 3D volume. Additionally, we apply DAC on functional OCT angiography data to improve lateral resolution and compensate for defocus. The speed necessities for the use of DAC in patient imaging are quantified by measuring the axial motion of 36 subjects. The first demonstration of DAC on OCT angiography as well as the motion analysis is important for future work dealing with DAC.
Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas (1989)

We did a multivariate analysis of 1262 patients with operable, invasive ductal breast carcinoma to assess the prognostic value of the Scarff-Bloom-Richardson (SBR) histologic grading system. Nodal metastasis and SBR were the two most important factors for metastasis-free survival (MFS), P = 10-9 and P = 10-5, respectively, for total study time. In patients who were node negative, the SBR and International Union Against Cancer (UICC) stages were the most important for MFS (P = 4 X 10-4 and P = 0.03). In order to try to improve the SBR prognostic value, we first studied the three components of the SBR separately: ductoglandular differentiation proved the least predictive and nuclear pleomorphism and mitotic index the most predictive. A rearrangement of the two nuclear scores alone produced higher risk values and better risk separation of patient subpopulations than SBR, and eliminated the SBR from the multivariate model. This rearrangement, modified SBR (MSBR), defined five new risk subgroups with statistically different risk ratios for MFS (P = 3 X 10-8). SBR grade II (55% of patients) was separated into three MSBR groups significantly different according to MFS (P = 0.008). In the patients who were node negative, MSBR replaced the SBR and was the most important factor for prediction of relapse of MFS (P less than 0.00001). The MSBR is more accurate and predictive than the standard SBR grade and is particularly useful when the nodal status of the patient is negative or unknown.
How to withstand mobile virus attacks (extended abstract) (1991)

Article Free Access Share on How to withstand mobile virus attacks (extended abstract) Authors: Rafail Ostrovsky MIT Laboratory for Computer Science, 545 Technology Sq., Cambridge MA MIT Laboratory for Computer Science, 545 Technology Sq., Cambridge MAView Profile , Moti Yung IBM Research, T.J, Watson Center, Yorktown, NY IBM Research, T.J, Watson Center, Yorktown, NYView Profile Authors Info & Claims PODC '91: Proceedings of the tenth annual ACM symposium on Principles of distributed computingJuly 1991 Pages 51–59https://doi.org/10.1145/112600.112605Online:01 July 1991Publication History 321citation1,803DownloadsMetricsTotal Citations321Total Downloads1,803Last 12 Months56Last 6 weeks15 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Probing cytoskeleton modulation by optical biosensors (2005)

This paper reported the use of resonant waveguide grating biosensors for studying the cytoskeleton structure in cells. This was achieved by measuring the changes in mass within the bottom portion of cells upon exposure to saponin in the absence and presence of cytoskeleton modulators. Treatment of Chinese hamster ovary cells with saponin led to a dose-dependent and dynamic mass changes. When a higher concentration of saponin (> 60 microg/ml) was used, a net loss in mass was observed. This is probably resulted from the diffusion of soluble intracellular materials away from the bottom portion of cells after pore formation in the cell plasma membranes by saponin. The pretreatment of cells with actin disruption agents, cytochalasin B and latrunculin A, led to significantly increased loss in cell mass induced by either 75 or 125 microg/ml saponin. These results suggested that optical biosensors provide an attractive means to study the cytoskeleton structure and screen modulators that affect the cytoskeleton structure.