gebhart/patrepeval huggingface dataset:
NG-Nitro-L-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Synthesis, Ameliorates Interleukin-2-induced Capillary Leak Syndrome in Healthy Mice (1995)

We tested whether NG-nitro-L-arginine methyl ester (L-NAME), a potent inhibitor of NO synthesis, can prevent interleukin-2 (IL-2)-induced capillary leakage. Healthy C3H/HeJ female mice were treated with: nothing; IL-2 (10 injections; 35,000, 15,000, or 7,500 Cetus U i.p. every 8 h); IL-2 + L-NAME (0.01, 0.1, 0.5, and 1 mg/ml of drinking water starting 1 day before IL-2 therapy and ending with IL-2 therapy); or L-NAME alone. In the first series of experiments, mice were killed 1 h after last IL-2 injection to measure pleural effusion, and water content of the lungs, spleen, and kidney (markers of capillary leakage), as well as NO2- + NO3- levels in the serum and pleural effusion. In the two additional series, the survival of treated mice was followed. All doses of IL-2-induced capillary leak syndrome as indicated by pleural effusion, pulmonary edema, and fluid retention in the spleen and kidney. NO production was positively correlated with manifestation and severity of this syndrome. NO2- + NO3- levels in the pleural effusion were directly related to IL-2 dose, and L-NAME treatment reduced both the NO production and severity of capillary leakage, excepting fluid retention in the kidney. However, L-NAME therapy prevented IL-2-induced mortality only when combined with a middle range IL-2 dose (15,000 U/injection). In summary, oral L-NAME therapy effectively prevented IL-2-induced capillary leakage in healthy mice, suggesting its potential value as a supplement in IL-2-based immunotherapy of cancer and infectious diseases.
Rethermalization of a field-reversed configuration plasma in translation experiments (1995)

A translation experiment of field-reversed configuration (FRC) plasma is performed on the FIX machine [Shiokawa and Goto, Phys. Fluids B 5, 534 (1993)]. The translated FRC bounces between magnetic mirror fields at both ends of a confinement region. The plasma loses some of its axial kinetic energy when it is reflected by the magnetic mirror field, and eventually settles down in the confinement region. In this reflection process, the plasma temperature rises significantly. Such plasma rethermalization has been observed in OCT-L1 experiments [Ito et al., Phys. Fluids 30, 168 (1987)], but rarely in FRX-C/T experiments [Rej et al., Phys. Fluids 29, 852 (1986)]. It is found that the rethermalization depends on the relation between the plasma temperature and the translation velocity. The rethermalization occurs only in the case where the translation velocity exceeds the sound velocity. This result implies the rethermalization is caused by a shock wave induced within the FRC when the plasma is reflected by the magnetic mirror field.
Cardiac troponin I and beta 2 microglobulin as risk factors for early‐onset atherosclerosis in patients on haemodialysis (2005)

Besides well-known cardiovascular (CV) risk factors, cTnI and beta2M were related with C-IMT in that they may have important roles in early-onset atherosclerosis in this high-risk population.
Room temperature polyesterification (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRoom temperature polyesterificationJeffrey S. Moore and Samuel I. StuppCite this: Macromolecules 1990, 23, 1, 65–70Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ma00203a013https://doi.org/10.1021/ma00203a013research-articleACS PublicationsRequest reuse permissionsArticle Views7806Altmetric-Citations486LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bacteria identification of otitis media with fluorescence spectroscopy (1994)

We have investigated the fluorescence profiles of four common pathogens: S. pneumoniae, S. aureus, M. catarrhalis, and H. influenzae. The steady-state auto fluorescence spectra of bacteria are measured as a function of the incident light from 200 to 700 nm. The spectra for each bacterium are combined into a fluorescence profile or fluorescence finger print. Each bacterium produces a unique in vitro fluorescence profile when measured in a saline suspension. The profiles are reproducible. Suspensions of a bacterial strain, where the identification is not known, can be correctly matched to a small library of previously measured fluorescence profiles using a linear least-squares fitting algorithm. In addition, we have measured the fluorescence and absorption spectrum of the tympanic membrane removed from a chinchilla. The optical properties of the tympanic membrane and the least-squares identification process form precept for a non-invasive, fluorescence based bacterial diagnosis technique to be used in otitis media.
Adaptive duplexer for multiband transreceiver (2004)

This paper proposes new adaptive duplexer architecture for multiband systems. It reduces the need for multiple switched duplexers. The propose new technique is based on two step isolation processes: (1) a wide-band circulator (20 dB isolation); and (2) an active double loop canvelling technique that leads to two nulls at the desired frequency and the transmitted frequency. This solution is based on multiband direct conversion receiver. In a direct conversion receiver a simple synchronous detector at the duplex offset frequency provides a convenient feedback signal. Using this approach it was possible to achieve 66 dB total isolation between the transmit signal and the receive signal and 37 dB total transmitter noise cancellation at the receiver band. Adaptive duplexing eliminates many external components in multiband transceiver front end. The described scheme is simple, uses a relatively low frequency error signals and has low computational complexity.
Expression of CaT-like, a Novel Calcium-selective Channel, Correlates with the Malignancy of Prostate Cancer (2001)

The regulation of intracellular Ca(2+) plays a key role in the development and growth of cells. Here we report the cloning and functional expression of a highly calcium-selective channel localized on the human chromosome 7. The sequence of the new channel is structurally related to the gene product of the CaT1 protein cloned from rat duodenum and is therefore called CaT-like (CaT-L). CaT-L is expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but is undetectable in healthy prostate tissue and benign prostatic hyperplasia. Additionally, CaT-L is expressed in normal placenta, exocrine pancreas, and salivary glands. New markers with well defined biological function that correlate with aberrant cell growth are needed for the molecular staging of cancer and to predict the clinical outcome. The human CaT-L channel represents a marker for prostate cancer progression and may serve as a target for therapeutic strategies.
Spectral diagnosis of a laser-produced XUV source using a digital camera system with pinhole transmission grating (1991)

For spectral diagnosis, a repetitive laser-produced soft-X-ray source was examined in the range 2–40 nm using a spectrometer containing a pinhole transmission grating, an image converter, and a CCD camera. Via digital recording the detection system provides fast on-line data accumulation with spectral and spatial resolution. With this detector the performance of the light source was studied with respect to spectral emission characteristics, long-term stability, and reproducibility by recording spectra for different solid targets and liquid lead.
Oligonucleotide N3′→P5′ Thio‐phosphoramidate Telomerase Template Antagonists as Potential Anticancer Agents (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Natural History of Chronic Allograft Nephropathy (2003)

Chronic allograft nephropathy represents cumulative and incremental damage to nephrons from time-dependent immunologic and nonimmunologic causes.
Properties of lipid-apolipoprotein association products. Complexes of human apo AI and binary phospholipid mixtures. (1980)

The products resulting from the association of human apo A-I with binary phospholipid mixtures of dimyristoyl phosphatidylcholine (DMPC) and either dipalmitoyl (DPPC) or distearoyl (DSPC) phosphatidylcholine have been isolated and characterized. Effective lipid . protein complex formation was found to occur at the onset temperature for melting of the gel state, and equal incorporation of both lipid components of the binary mixture was observed. Two sizes of products were obtained, one containing 2 A-I molecules per complex and the other containing 3; the proportions of these two products depended upon the initial phospholipid/protein ratio employed. these two product species were found to be resolvable by density gradient centrifugation as well as gel filtration, reflecting substantial differences in composition as well as size. The ratio of DMPC to DPPC or DSPC was the same in the isolated complexes as in the initial mixture, suggesting that th protein does not associate preferentially with the fluid phase lipid, but with lipid domains in which the components are randomly distributed. Electron microscopy of recombinant particles containing a 2:1 ratio (w/w) of DSPC to DMPC revealed stacks of discs whose thickness was proportionately greater than for discs containing DMPC alone. Also of significance was the finding that recombinant discs containing 3 A-I molecules possessed a diameter approximately 1.5 times larger than recombinant discs containing 2 A-I molecules. These data are consistent with the model for the recombinant particles described by Tall et al. (Tall, A.R., Small, D.M., Deckelbau, R.J., and Shipley, G.G. (1977) J. Biol. Chem. 252; 4701-4711), in which the phospholipid is found as a circular bilayer, the thickness of which is dependent upon the length of the acyl chain, and around which the protein is distributed as an annulus.
Glial inhibition of nerve regeneration in the mature mammalian CNS (2000)

The lack of axonal regeneration in the adult mammalian CNS is due to both unfavorable environmental glial factors and the intrinsic neuronal state. Inhibitors associated with myelin and the glial scar have been extensively studies and it has been shown that neutralizing at least some of the inhibitors can lead to improved growth. Meanwhile, important advances have also been made towards our understanding of the neuronal intrinsic state, particularly the intracellular levels of cyclic nucleotide, that influence the capacity of mature CNS neurons to initiate and maintain a regrowth response. It is well recognized that successful regeneration may only be achieved by application of a combination of strategies that both block glial inhibitors and enhance the intrinsic neuronal growth capacity.
Comparison of Global Ammonia Chemistry Mechanisms in Biomass Combustion and Selective Noncatalytic Reduction Process Conditions (2007)

The success of computational fluid dynamics (CFD)-based combustion modeling is strongly dependent on several submodels which are required to close the Favre-averaged conservation equations for mass, momentum, and energy and transport equations for scalar quantities. Due to the requirement of high computer capacity, global mechanisms are frequently applied to model chemical reactions in industrial-scale CFD. The present study compares the performance of five global ammonia chemistry mechanisms in the conditions typical of the biomass combustion in fluidized beds. A special emphasis is given to the modeling of the selective noncatalytic reduction (SNCR) process. A modification of the standard k–ε model is used to model turbulence, the eddy dissipation combustion model and the eddy dissipation concept are used to model turbulence–chemistry interaction, and the finite-volume method (discrete ordinates) together with the weighted sum of gray gases model are used to model radiative heat transfer. A simplified approach is used to consider the bubbling bed in the overall CFD model. Experimental data available on the temperature and the concentrations of NH3 and NO are presented to validate the predictions to a certain extent. The results are shown to be strongly dependent on the chemistry model. Global chemistry models typically perform well under the conditions for which they were derived, but under other conditions, they may fail badly. Models suitable for modeling the SNCR process are identified, and it is shown that the correct emission trends can be predicted as a function of the SNCR process load. Due to the different conditions in the lower part near the bubbling bed and the upper section of the freeboard, a combination of more than one model may be a good approach in modeling the overall process.
Cyclic peptide disulfides. Solution and solid-state conformation of Boc-Cys-Pro-Aib-Cys-NHMe with a disulfide bridge from Cys to Cys, a disulfide-bridged peptide helix (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic peptide disulfides. Solution and solid-state conformation of Boc-Cys-Pro-Aib-Cys-NHMe with a disulfide bridge from Cys to Cys, a disulfide-bridged peptide helixA. Ravi, B. V. Venkataram Prasad, and P. BalaramCite this: J. Am. Chem. Soc. 1983, 105, 1, 105–109Publication Date (Print):January 1, 1983Publication History Published online1 May 2002Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/ja00339a019https://doi.org/10.1021/ja00339a019research-articleACS PublicationsRequest reuse permissionsArticle Views420Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Some electrical and optical properties of ferroelectric lead-zirconate–lead-titanate thin films (1977)

Ferroelectric and transparent thin films of lead-zirconate–lead-titanate (PZT) were fabricated by rf diode sputtering. The substrates used were platinum, fused quartz, and In2O3-coated fused quartz, but no substantial difference on the film properties was observed. Films deposited at substrate temperatures below 300 °C were amorphous. At substrate temperatures of 350–450 °C the films crystallized in a pyrochlore structure. Films deposited at above 500 °C showed a perovskite structure and ferroelectric properties. The measured dielectric constant of the ferroelectric PZT was 751. Spontaneous polarization of the film was 26.1 μC/cm2 and the Curie temperature was 325 °C. The coercive field and remanent polarization were found to be 23.3 kV/cm and 20.4 μC/cm2, respectively. The refractive index of the perovskite PZT film was 2.36 at 6328 Å, and the absorption edge was found to be at 2950 Å. The edge of the pyrochlore film was at 3300 Å. Optical waveguiding properties of the PZT thin film were investigated at 6328 Å, but attenuation was impracticably large.
ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR (1989)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Biological grading of breast cancer using antibodies to proliferating cells and other markers. (1989)

Quantitation of immunohistochemical staining by image analysis was performed on 50 breast cancers stained with the monoclonal antibody Ki-67 to determine the growth fraction and its correlation with tumor grade. A high degree of correlation was shown. For each case the DNA ploidy was determined by quantitation of the DNA Feulgen stain by computerized microdensitometry. DNA content of breast tumor cells correlated to the histopathologic grade at which poorly differentiated tumors are more likely to be aneuploid. Quantitation of immunohistochemistry for estrogen and progesterone receptors had a high degree of correlation with the steroid binding assay, such as dextran-coated charcoal assay (DCCA), and were weakly correlated to histologic grade. In summary, our results indicated that quantitation of Ki-67-positive nuclear area and of DNA content by image analysis provides an objective method for assessing tumor cell growth fraction and DNA ploidy. Quantitation of steroid receptors by immunohistochemistry is a better and easier technique than those currently used to determine the best therapy for postmenopausal women. These methods can be performed on small frozen sections or needle aspirates in quantities that are insufficient for current steroid binding assays. Thus, this method is prognosticly useful even for patients with small breast lesions.
Asymmetric Total Synthesis of (+)-Milbemycin D (1996)

The enantioselective total synthesis of the potent antiparasitic agent milbemycin D (1) has been achieved. The spiroketal fragment is prepared through a novel spiroketalization of a hydroxy pyrone to set the anomeric stereocenter and establish functionality for the stereocontrolled attachment and subsequent extension of the connecting chain between the spiroketal and the hexahydrobenzofuran fragment. The hexahydrobenzofuran fragment is constructed through the exploitation of a sequential electrophilic cyclization−[2,3]-sigmatropic rearrangement to close the oxygen-containing ring and incorporate the C5 hydroxyl. A lithium bromide accelerated Wittig olefination joins the spiroketal-containing subunit and the hexahydrobenzofuran subunit at the C10,11 double bond in high yield. Subsequent oxidation of the C1 hydroxyl provides access to the seco acid, which smoothly undergoes macrolactonization. The sensitive C2 stereochemistry and the C3,4 double bond are incorporated without epimerization at C2 or migration of the C3,4 double bond.
An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques (2015)

The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0, 1-month vaccination schedule in rhesus macaques. One month after dose 2, all adjuvanted formulations elicited robust and persisting neutralizing antibody titers against all four dengue virus serotypes. Most of the formulations tested prevented viremia after challenge, with the dengue serotype 1 and 2 virus strains administered at 40 and 32 weeks post-dose 2, respectively. This study shows that inactivated dengue vaccines, when formulated with alum or an Adjuvant System, are candidates for further development.
Peptide‐mediated regulation of the allergic immune response (1996)

A major key to successful immunotherapy may depend on altering the qualitative nature of the immune response in allergic patients. In this review we examine how immune responses to environmental allergens are regulated, and the mechanisms used by the immune system to prevent allergic sensitization. We also discuss future prospects of using allergen-derived peptides in immunotherapy and the possibility of 'reprogramming' the immune responses by immunizing under conditions that promote Th1 responses instead of Th2 responses.
The recurrent expression of variable region segments in human IgM anti-DNA autoantibodies. (1989)

RNA sequences for the V regions of human hybridoma-produced autoantibodies were determined by primer extension with reverse transcriptase. The sequencing of IgM autoantibodies from a leprosy patient revealed examples of recurrent use of V region gene segments in different autoantibodies from this patient and a previously studied patient with SLE. Moreover, several gene segments used in these autoantibodies show little alteration from germ-line sequences. mAb TH3, from a patient with leprosy, binds denatured DNA and poly(dT). The center of its H chain CDR35 has a sequence identical to that found previously in two anti-DNA antibodies from a lupus patient; these identities and their overlapping with two other published sequences define a human D-gene segment of approximately 25 nucleotides. Autoantibody TH9, from a leprosy patient, does not bind DNA. Its VH sequence has 87% identity with a VHI anti-DNA antibody, but differs from it markedly in the CDR1 region. TH9 also has a different H chain CDR3. The closely related JH4 or JH5 gene segments are expressed in five lupus or leprosy autoantibodies. In four of the antibodies, examples of V kappa 1, V kappa 3, or V kappa 4 and J kappa 2, or J kappa 5 segments were found. Two distinct leprosy-derived anti-DNA antibodies, 8E10 and TH3, share a completely identical V kappa sequence. This sequence differs in only two positions from that of a germ-line RF L chain gene. Several gene segments that are close to the germ line in sequence encode Ig V regions with autoantibody reactivity. These results provide a base line for determining whether these genes are precursors of more highly diversified antibodies that may be pathogenic in patients with SLE.
Specific Hydrogen-Bond-Mediated Recognition and Modification of Surfaces Using Complementary Functionalized Polymers (2003)

Specific hydrogen-bonding interactions between polymers and surface-tethered recognition elements were used to selectively modify self-assembled monolayers (SAMs) on gold. The interfacial recognition processes were followed by observing frequency changes of thymine-SAM modified quartz crystal microbalance (QCM) chips during adsorption of diamidopyridine-functionalized (DAP) polystyrene from a nonpolar solvent. QCM studies combined with X-ray photoelectron spectroscopy (XPS), water contact angle, and ellipsometry measurements of the polymer-modified surfaces demonstrate the selectivity of the polymer-surface hydrogen-bonding interactions. These studies also indicate that the degree of recognition element functionalization of both the polymer and the surface is crucial in determining the rate, selectivity, and coverage of polymer on the surface.