gebhart/patrepeval huggingface dataset:
Electronic structure and bonding properties of titanium silicides (1998)

We present an ab initio full-potential linear muffin-tin orbital study of the structural and electronic properties of seven compounds of the binary Ti-Si system. The calculations were done with the compounds in their proposed stable structures, which are $A3$ Ti, ${D8}_{8}$ ${\mathrm{Ti}}_{5}{\mathrm{Si}\mathrm{}}_{3}$, $B27$ TiSi, TiSi in distorted ${L1}_{0}$, $C49$ ${\mathrm{TiSi}}_{2}$, $C54$ ${\mathrm{TiSi}}_{2}$, and $A4$ Si. The calculated enthalpies of formation reproduce the observed sequence of stable structures and agree reasonably well with the values deduced from experiments. The paper ends with an analysis of the electronic structure and the bonding in the stable phases, which shows that the properties of the experimentally observed stable phases differ considerably from those of the hypothetical unstable structures. Therefore, the latter represent a poor model for the bonding in some of the stable Ti-Si compounds. We suggest that the bonding in these structures has a complex character extending beyond simple Ti-Ti and Ti-Si pairwise interactions.
Differential Adeno-Associated Virus Mediated Gene Transfer to Sensory Neurons following Intrathecal Delivery by Direct Lumbar Puncture (2010)

The present study demonstrates the feasibility of minimally invasive gene transfer to sensory neurons using direct lumbar puncture and provides evidence for differential targeting of subtypes of DRG neurons by AAV vectors.
Phosphorylation of CARMA1 by HPK1 is critical for NF-κB activation in T cells (2009)

Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced NF-kappaB activation. Knock-down of HPK1 abrogates TCR-induced IKKbeta and NF-kappaB activation, whereas active HPK1 leads to increased IKKbeta activity in T cells. Yet, the precise molecular mechanism of this process remains elusive. Here, we show that HPK1-mediated NF-kappaB activation is dependent on the adaptor protein CARMA1. HPK1 interacts with CARMA1 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARMA1. Interestingly, the putative HPK1 phosphorylation sites in CARMA1 are different from known PKC consensus sites. Mutations of residues S549, S551, and S552 in CARMA1 abrogated phosphorylation of a CARMA1-linker construct by HPK1 in vitro. In addition, CARMA1 S551A or S5549A/S551A point mutants failed to restore HPK1-mediated and TCR-mediated NF-kappaB activation and IL-2 expression in CARMA1-deficient T cells. Thus, we identify HPK1 as a kinase specific for CARMA1 and suggest HPK1-mediated phosphorylation of CARMA1 as an additional regulatory mechanism tuning the NF-kappaB response upon TCR stimulation.
Endogenous interleukin-12 is involved in resistance to Brucella abortus infection (1995)

Protective immunity against Brucella abortus is mediated by acquired cellular resistance, with gamma interferon (IFN-gamma)-producing T cells playing a key role. Interleukin-12 (IL-12) is a cytokine that has a profound effect on the induction of IFN-gamma-producing Th1 and NK cells. Here we report that depletion of endogenous IL-12 before infection of mice significantly exacerbated brucella infection. IL-12-depleted mice also had reduced splenomegaly resulting from infection and showed a decrease in percentage and absolute numbers of macrophages compared with those in control infected mice. Furthermore, spleen cells from IL-12-depleted mice had a reduced ability to produce nitrite, a product of activated macrophages. This could be the result of the low production of IFN-gamma by splenic T cells observed in the IL-12-depleted mice. The mechanism whereby IL-12 controls antibacterial resistance is discussed.
Grids in Design and CAD (1991)

The grid is a useful device for expressing design rules about the placement of elements in a layout. By expressing position rules for elements in relation to a grid, a designer can systematically organize decisions in a layout design problem. Grids and placement rules offer a discipline that can help a designer work effectively to lay out complex designs, and it can also facilitate group design work. Unfortunately, computer supported drawing systems often cannot support this way of working because they lack a sufficiently rich implementation of grids. The Grid Manager module of the CoDraw program shows enhancements useful for architectural Computer Assisted Design. These enhancements would enable more effective ways of using the computer as a design tool.
N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders (2017)

Aberrant excitatory neurotransmission associated with overproduction of glutamate has been implicated in the development of HIV-associated neurocognitive disorders (HAND). The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 14) attenuates glutamate synthesis in HIV-infected microglia/macrophages, offering therapeutic potential for HAND. We show that 14 prevents manifestation of spatial memory deficits in chimeric EcoHIV-infected mice, a model of HAND. 14 is not clinically available, however, because its development was hampered by peripheral toxicities. We describe the synthesis of several substituted N-(pivaloyloxy)alkoxy-carbonyl prodrugs of 14 designed to circulate inert in plasma and be taken up and biotransformed to 14 in the brain. The lead prodrug, isopropyl 6-diazo-5-oxo-2-(((phenyl(pivaloyloxy)methoxy)carbonyl)amino)hexanoate (13d), was stable in swine and human plasma but liberated 14 in swine brain homogenate. When dosed systemically in swine, 13d provided a 15-fold enhanced CSF-to-plasma ratio and a 9-fold enhanced brain-to-plasma ratio relative to 14, opening a possible clinical path for the treatment of HAND.
Dielectrophoretic Cell Separation and Gene Expression Profiling on Microelectronic Chip Arrays (2002)

Cell membrane dielectric properties of five different cultivated cell lines and human peripheral blood mononuclear cells (PBMC) were determined from dielectrophoretic crossover frequency measurements on a 5 x 5 microelectronic chip array. Based on distinct dielectric property differences between individual cell types, efficient cell separations were achieved by dielectrophoresis on this 5 x 5 array, which included separation of monocytic cells (U937) or human T cell leukemia virus type 1 (HTLV-1) tax-transformed cells (Ind-2) from PBMC, as well as separation of neuroblastoma cells (SH-SY5Y) from glioma cells (HTB). The purity of dielectrophoretically separated cells can be greater than 95%. Expression profiles of IL-1, TNF-alpha, and TGF-beta genes for U937 cells mixed with PBMC before and after the separation were determined by a means of electric field-facilitated hybridization on a 10 x 10 microelectronic chip array. By using the expression levels of pure U937 cells as a control, it was shown that the gene expression profiles of the postseparation cells were significantly different from those of the preseparation cell mixtures. The increase in gene expression levels for U937 cells upon lipopolysaccharide induction could be accurately determined only in the postseparation cells, while the preseparation samples masked these changes. Furthermore, by cultivating the separated HTB and SH-SY5Y cells and measuring expression of the stress-related gene c-fos, dielectrophoretic forces were shown to have little effect on cell survival and stress. The presented approach of using microelectronic chip arrays for both cell separation and gene expression profiling provides a great potential for accurate genetic analysis of specific cell subpopulations in heterogeneous samples.
Framed Round-Robin Arbitration with Explicit Feedback Control for Combined Input-Crosspoint Buffered Packet Switches (2006)

This paper introduces a frame-based round-robin arbitration scheme with explicit feedback control (FRE) for combined input-crosspoint buffered packet switches. We consider a CICB switch with fixed-length packets, called cells. The proposed scheme dynamically sets the frame size according to the amount of cell accumulation at the input queues. We study FRE when applied to a continuous system. We transport the FRE concept into a discrete system as an arbitration scheme for a packet switch, and study the switching performance. We combine FRE, which is used as the input arbitration scheme, with other round-robin based schemes, used as output arbitration schemes. The resulting combined schemes provide high throughput under several admissible traffic patterns when used in a switch with one-cell crosspoint buffers and no speedup.
Phylogeny of Zika Virus in Western Hemisphere, 2015 (2016)

into regions that are ill-equipped to manage imported cutaneous leishmaniasis has resulted in outbreaks in Turkey and Lebanon (5,6).
Advances in the Production of Poly(Lactic Acid) Fibers. A Review (2003)

Abstract Poly(lactic acid) has recently seen its development as a textile fiber. With the resin prepared from agricultural feedstock, the fiber has properties typical of a synthetic fiber, while still being fully biodegradable. This article is an attempt to review recent research developments which have taken this polymer from a specialty suture material to a commodity fiber. Various approaches for the preparation of fiber grade polymer from monomers and its conversion into textile grade filament are discussed. Both solution spinning and melt spinning technology along with physical properties of the fibers are discussed in detail.
Meniscal repair using an exogenous fibrin clot. An experimental study in dogs. (1988)

To evaluate the ability of a fibrin clot to stimulate and support a reparative response in the avascular portion of the meniscus, two-millimeter-diameter full-thickness lesions in the avascular portion of the medial meniscus of twelve adult dogs were filled with an exogenous fibrin clot that had been prepared from each animal. The healing response was then examined using histology and autoradiography with 35SO4 at intervals from one week to six months. The defects that had been filled with a fibrin clot healed through a proliferation of fibrous connective tissue that eventually modulated into fibrocartilaginous tissue. The fibrin clot appeared to act as a chemotactic and mitogenic stimulus for reparative cells and to provide a scaffolding for the reparative process. The origin of these reparative cells was not determined in this study, but they were thought to arise from the synovial membrane as well as the adjacent meniscal tissue. Control defects remained empty. While the reparative tissue was grossly and histologically different from the normal adjacent meniscal tissue, it was morphologically similar to the reparative tissue that was previously observed in the vascular area of the meniscus. CLINICAL RELEVANCE: The ability of an exogenous fibrin clot to stimulate and support a reparative response in the avascular portion of the meniscus may represent a potential method of avascular meniscal repair.
Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. (1995)

Elevated levels of endogenous angiotensin can cause hypertensive nephrosclerosis as a result of the potent vasopressor action of the peptide. We have produced by gene targeting mice homozygous for a null mutation in the angiotensinogen gene (Atg-1-). Postnatally, Atg-1- animals show a modest delay in glomerular maturation. Although Atg-1- animals are hypotensive by 7 wk of age, they develop, by 3 wk of age, pronounced lesions in the renal cortex, similar to those of hypertensive nephrosclerosis. In addition, the papillae of homozygous mutant kidneys are reduced in size. These lesions are accompanied by local up-regulation of PDGF-B and TGF-beta1 mRNA in the cortex and down-regulation of PDGF-A mRNA in the papilla. The study demonstrates an important requirement for angiotensin in achieving and maintaining the normal morphology of the kidney. The mechanism through which angiotensin maintains the volume homeostasis in mammals includes promotion of the maturational growth of the papilla.
Efficacy of Preventive Analgesia with Tramadol or Lornoxicam for Percutaneous Nephrolithotomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study (2007)

Tramadol and lornoxicam were more effective than NS in preventing early postoperative pain. The preventive analgesic effect of tramadol was comparable with that of lornoxicam, except at 1 hour when tramadol was more effective among these patients undergoing PCNL. Both drugs were well tolerated.
Chiroptical Properties of Regioregular Chiral Polythiophenes (1994)

Abstract The synthesis and (chir)optical properties of a highly regioregular optically active 3-substituted polythiophene are reported. Using the McCullough method a regioselectivity of more than 98% is found for the head-to-tail coupling in 3-[2-((S)-2-methylbutoxy)ethyl]polythiophene 1. Contrary to the small effects observed for the regiorandom analogue 2, made by FeCl3-polymerization, 1 shows a strong induced optical activity in its π-π* transition, provided the polymer is in its almost coplanar associated form. This association with a strong conformational rigidity, a prerequisite for a stable chirality from a helical structure of 1, is found in poor-solvents as well as in the solid state. In a good solvent like CHCl3, the disordered non-planar structure is optically inactive in its backbone. The transfer to an associated form is accompanied with solvatochromism and thermochromism in absorption, while significant changes in fluorescence behaviour and in the circular dichroism spectra are observed. All techniques show fine structure in the almost coplanar state while all absorptions are exciton coupled, reflecting the Davydov splitting of the coupled excited states.
Novel three-phase SMR converter with inherent snubber energy recovery capability (1996)

This paper describes the switch mode rectifier (SMR) having a quite new circuit configuration, which has been developed by the authors and given the name "DC clamped type SMR" (DCC-SMR). The DCC-SMR is unique in that no bilateral switching device is used in the frequency conversion circuit. Therefore, the authors have used a DC snubber circuit in conjunction with the switching device of the DCC-SMR. This DC snubber circuit features a very simple structure consisting only of a capacitor with no need for a discharge resistance or for a complicated regenerative circuit for snubber energy. This is because snubber energy is regenerated on the primary side of the high frequency (HF) transformer by the main switch. Furthermore, an innovative method has been applied for magnetic saturation-preventive control of the HF transformer. The authors carried out operational checks on the main circuit and the snubber circuit of the DCC-SMR as well as on the magnetic saturation-preventive control circuit, and through experiments confirmed a satisfactory result. We manufactured an industrial DC power supply prototype of the DCC-SMR system having a DC output of 100 kW (100 V, 1000 A), with which input/output conversion efficiency 91.6%, input power factor 0.99 and input current total harmonic distortion factor 4.6% were obtained.
Interaction between Insulin-Like Growth Factor-I Receptor and αVβ3 Integrin Linked Signaling Pathways: Cellular Responses to Changes in Multiple Signaling Inputs (2004)

Integrins are heterodimeric transmembrane proteins that mediate cell attachment to extracellular matrix, migration, division, and inhibition of apoptosis. Because growth factors are also important for these processes, there has been interest in cooperative signaling between growth factor receptors and integrins. IGF-I is an important growth factor for vascular cells. One integrin, alphaVbeta3, that is expressed in smooth muscle cells modulates IGF-I actions. Ligand occupancy of alphaVbeta3 is required for IGF-I to stimulate cell migration and division. Src homology 2 containing tyrosine phosphatase (SHP-2) is a tyrosine phosphatase whose recruitment to signaling molecules is stimulated by growth factors including IGF-I. If alphaVbeta3 ligand occupancy is inhibited, there is no recruitment of SHP-2 to alphaVbeta3 and its transfer to downstream signaling molecules is blocked. Ligand occupancy of alphaVbeta3 stimulates tyrosine phosphorylation of the beta3-subunit, resulting in recruitment of SHP-2. This transfer is mediated by an insulin receptor substrate-1-related protein termed DOK-1. Subsequently, SHP-2 is transferred to another transmembrane protein, SHPS-1. This transfer requires IGF-I receptor-mediated tyrosine phosphorylation of SHPS-1, which contains two YXXL motifs that mediate SHP-2 binding. The transfer of SHP-2 to SHPS-1 is also required for recruitment of Shc to SHPS-1. Ligand occupancy of alphaVbeta3 results in sustained Shc phosphorylation and enhanced Shc recruitment. Shc activation results in induction of MAPK. Inhibition of the Shc/SHPS-1 complex formation results in failure to achieve sustained MAPK activation and an attenuated mitogenic response. Thus, within the vessel wall, a mechanism exists whereby ligand occupancy of the alphaVbeta3 integrin is required for assembly of a multicomponent membrane signaling complex that is necessary for cells to respond optimally to IGF-I.
New Technique for Gene Transfection Using Laser Irradiation (2001)

This method enables us to transfect targeted cells, ie, cells in suspension as well as attached cells, with a simple technique that does not involve harmful vectors. The present method is very useful for gene transfection in cellular biotechnology.
Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs. (1990)

We gave atropine intravenously to autonomically decentralized, open-chest, anesthetized dogs and stimulated the discrete intracardiac sympathetic nerve fibers to the sinoatrial (SA) (SAS stimulation) or atrioventricular (AV (AVS stimulation) nodal region. A brief burst of neural stimuli was delivered during each cardiac cycle. SAS stimulation consistently decreased the atrial cycle length but had variable effects on the AV interval. The positive chronotropic response to SAS stimulation increased when the level of stimulation (i.e., stimulus pulse duration, pulse amplitude, and number of pulses per burst) was increased. When the heart rate was held constant by atrial pacing, SAS stimulation did not change the AV interval. AVS stimulation decreased the AV conduction time but did not change the atrial cycle length. The AV conduction response increased when the level of AVS stimulation was increased. A high level of AVS stimulation induced an AV junctional rhythm in seven of eight experiments. When the atrial pacing interval was decreased, the basal AV interval increased, and the decrease in AV interval induced by AVS stimulation was exaggerated. The chronotropic response to SAS stimulation and the dromotropic response to AVS stimulation were abolished by propranolol given systemically and by lidocaine given topically. From these results, we conclude that in anesthetized dogs treated with atropine, activation of the discrete intracardiac sympathetic nerves to the SA and AV nodal regions controls the sinus rate and AV conduction time independently and activation of the discrete sympathetic nerves may shift the dominant pacemaker site to a subsidiary site.
Syntheses and Applications of 2-Phosphino-2‘-alkoxy-1,1‘-binaphthyl Ligands. Development of a Working Model for Asymmetric Induction in Hydrovinylation Reactions (2007)

Among the handful of monophosphine ligands that effect asymmetric hydrovinylation of vinylarenes, 2-diphenylphosphino-2'-methoxy-1,1'-binaphthyl (MOP) is among the most accessible. Addition of a methyl group at the 3'-position of this ligand significantly improves the enantioselectivity of hydrovinylation of prototypical alkenes. Introduction of a chiral phospholane at the C2 position of this scaffolding has no effect on the enantioselectivity. These results are consistent with a model proposed for the asymmetric induction for this exacting reaction.
Characterization and comparison of vanadyl and nickel compounds in heavy crude petroleums and asphaltenes by reverse-phase and size-exclusion liquid chromatography/graphite furnace atomic absorption spectrometry (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization and comparison of vanadyl and nickel compounds in heavy crude petroleums and asphaltenes by reverse-phase and size-exclusion liquid chromatography/graphite furnace atomic absorption spectrometryRichard H. Fish, John J. Komlenic, and Brian K. WinesCite this: Anal. Chem. 1984, 56, 13, 2452–2460Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/ac00277a043https://doi.org/10.1021/ac00277a043research-articleACS PublicationsRequest reuse permissionsArticle Views544Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Study on Grain Refining and Metamorphism of ZL111 Aluminium Alloys (2006)

真空 sintering 和球 milling 方法在 Ti-C 谷物精炼和能力的准备过程被采用与改变 Ti 和 C 的比率重新好撕了好 ZL111 水晶谷物被测试。张力的力量上的 Ti-C 比率的精炼效果，延伸百分比， Brinell，支持类低共熔体的高山哈艾尔和 ZL111 的 Siphase 的尺寸修正由稀土元素并且硝酸锶，被工具 ofmetallographic 检查， SEM 和机械性质测试学习。结果证明张力的力量和与这些蝾螈 i 和 C 一起的精制 ZL111 的延伸百分比有明显的增加更精制的加重搽粉，当 Brinell 仍然保持差不多不变时。Thepro 类低共熔体 aAl 更加在尺寸被减少， Si 阶段显示出更好、更圆的结构。更精制的展览当 Ti-C 比率是 25:1 时，精制性能的好谷物， forAl 晶体能容易有利地形成原子核并且由剩余 Ti 和艾尔由于 TiAl_3generated 沿着 TiC 表面长大。机械性质被 ZL111 的硝酸锶的增加清楚地改进了。在 ZL111 的机械性质的修正的有效因素重要性是有序的：硝酸锶， Ti-C 比率和稀土元素。