gebhart/patrepeval huggingface dataset:
Stacked Microbial Desalination Cells to Enhance Water Desalination Efficiency (2011)

Microbial desalination cell (MDC) is a new method to obtain clean water from brackish water using electricity generated from organic matters by exoelectrogenic bacteria. Anions and cations, derived from salt solution filled in the desalination chamber between the anode and cathode, move to the anode and cathode chambers under the force of electrical field, respectively. On the basis of the primitive single-desalination-chambered MDC, stacked microbial desalination cells (SMDCs) were developed in order to promote the desalination rate in the present study. The effects of desalination chamber number and external resistance were investigated. Results showed that a remarkable increase in the total desalination rate (TDR) could be obtained by means of increasing the desalination cell number and reducing the external resistance, which caused the charge transfer efficiency increased since the SMDCs enabled more pairs of ions separated while one electron passed through the external circuit. The maximum TDR of 0.0252 g/h was obtained using a two-desalination-chambered SMDC with an external resistance of 10 Ω, which was 1.4 times that of single-desalination-chambered MDC. SMDCs proved to be an effective approach to increase the total water desalination rate if provided a proper desalination chamber number and external resistance.
ACOG Committee Opinion No. 409: Direct-to-Consumer Marketing of Genetic Testing (2008)

Marketing of genetic testing, although similar to direct-to-consumer advertising of prescription drugs, raises additional concerns and considerations. These include issues of limited knowledge among patients and health care providers of available genetic tests, difficulty in interpretation of genetic testing results, lack of federal oversight of companies offering genetic testing, and issues of privacy and confidentiality. Until all of these considerations are addressed, direct or home genetic testing should be discouraged because of the potential harm of a misinterpreted or inaccurate result.
Competitive Chain Transfer by .beta.-Hydrogen and .beta.-Methyl Elimination for a Model Ziegler-Natta Olefin Polymerization System [Me2Si(.eta.5-C5Me4)2]Sc{CH2CH(CH3)2}(PMe3) (1994)

The reaction of OpSc(H) (PMe_3) (Op = {(η^5-C_5Me_4)_2SiMe_2}) with isobutene produces OpSc(CH_3)(PMe_3) along with isobutene, 2-methylpentane, isobutene, 2-methyl-l-pentene, propane, and n-pentane. These products arise from a series of reactions involving olefin insertion, β-CH_3 and (faster) β-H elimination which proceed until only the 2-methyl-1-alkenes (C_4H_8, C_6H_(12), etc.) and the predominant organoscandium product OpSc(CH_3)(PMe_3) remain. A transient observed in the reaction sequence has been unambiguously characterized as OpSc(CH_2CH_2CH_3) (PMe_3). Slower u bond metathesis involving the methyl C-H bonds of PMe_3 and the Sc-C bonds of the scandium alkyls accounts for the observation of saturated alkanes (2-methylalkanes (C_4H_(10), C_6H_(14), etc.), normal alkanes (C_3H_8, C_5H_(12), etc.), and a minor organoscandium product OpScCH_2-PMe_2 in the product mixture. b-Ethyl migration is not observed for the closely related 2-ethylbutyl derivative, OpSC{CH_2CH(C_2H_5)CH_2CH_3}(PMe_3), obtained from reaction of 2-ethyl-1-butene with OpSc(H)(PMe_3).
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance (2005)

During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors, named CB1 receptor and CB2 receptor, first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral functions. CB2 receptor is mainly expressed in immune cells, whereas CB1 receptor is the most abundant G protein-coupled receptor expressed in the brain. CB1 receptor is expressed in the hypothalamus and the pituitary gland, and its activation is known to modulate all the endocrine hypothalamic-peripheral endocrine axes. An increasing amount of data highlights the role of the system in the stress response by influencing the hypothalamic-pituitary-adrenal axis and in the control of reproduction by modifying gonadotropin release, fertility, and sexual behavior. The ability of the endocannabinoid system to control appetite, food intake, and energy balance has recently received great attention, particularly in the light of the different modes of action underlying these functions. The endocannabinoid system modulates rewarding properties of food by acting at specific mesolimbic areas in the brain. In the hypothalamus, CB1 receptor and endocannabinoids are integrated components of the networks controlling appetite and food intake. Interestingly, the endocannabinoid system was recently shown to control metabolic functions by acting on peripheral tissues, such as adipocytes, hepatocytes, the gastrointestinal tract, and, possibly, skeletal muscle. The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases, including obesity.
Absence of L1 in pancreatic masses distinguishes adenocarcinomas from poorly differentiated neuroendocrine carcinomas. (2006)

Our data suggest that L1 is expressed in few cases of pancreatic ductal adenocarcinoma. Since L1 was previously found to be expressed specifically in neuroendocrine pancreatic carcinomas, its absence in unclear pancreatic masses might hint at a ductal origin for a malignant pancreatic tumor.
RTP Payload Format for Video Codec 1 (VC-1) (2006)

This memo specifies an RTP payload format for encapsulating Video
Codec 1 (VC-1) compressed bit streams, as defined by the Society of
Motion Picture and Television Engineers (SMPTE) standard, SMPTE 421M.
SMPTE is the main standardizing body in the motion imaging industry,
and the SMPTE 421M standard defines a compressed video bit stream
format and decoding process for television. [STANDARDS-TRACK]
The Apolipoprotein E ε4 Allele and Outcome in Cerebrovascular Disease (1998)

The APOE epsilon4 allele had divergent effects on survival and outcome in ischemic and hemorrhagic strokes in this population. The reported adverse effect on patients with intracerebral hemorrhage was supported. The favorable survival effect on ischemic stroke patients requires further study.
ShoeSense: A New Perspective on Hand Gestures and Wearable Applications (2012)

When the user is engaged with a real-world task it can be inappropriate or difficult to use a smartphone. To address this concern, we developed ShoeSense, a wearable system consisting in part of a shoe-mounted depth sensor pointing upward at the wearer. ShoeSense recognizes relaxed and discreet as well as large and demonstrative hand gestures. In particular, we designed three gesture sets (Triangle, Radial, and Finger-Count) for this setup, which can be performed without visual attention. The advantages of ShoeSense are illustrated in five scenarios: (1) quickly performing frequent operations without reaching for the phone, (2) discreetly performing operations without disturbing others, (3) enhancing operations on mobile devices, (4) supporting accessibility, and (5) artistic performances. We present a proof-of-concept, wearable implementation based on a depth camera and report on a lab study comparing social acceptability, physical and mental demand, and user preference. A second study demonstrates a 94-99% recognition rate of our recognizers.
Tau oligomers and tau toxicity in neurodegenerative disease (2012)

AD (Alzheimer's disease) is a progressive neurodegenerative disorder characterized by the extracellular accumulation of amyloid β-peptide and the intracellular accumulation of tau. Although there is much evidence linking tau to neurodegeneration, the precise mechanism of tau-mediated neurotoxicity remains elusive. The presence of tau-positive pre-tangle neurons lacking neurofibrillary tangles has been reported in AD brain tissue. In order to study this non-fibrillar tau, we generated a novel monoclonal antibody, named TOC1 (tau oligomeric complex 1), which selectively labels tau dimers and oligomers, but does not label filaments. Time-course analysis and antibody labelling indicates that oligomers appear as an early event in AD pathogenesis. Using a squid axoplasm assay, we have demonstrated that aggregated tau inhibits anterograde FAT (fast axonal transport), whereas monomeric tau has no effect. This inhibition requires a small stretch of N-terminal amino acids termed the PAD (phosphatase-activation domain). Using a PAD-specific antibody, TNT1 (tau N-terminal 1), we demonstrate that PAD exposure is increased in diseased neurons and this leads to an increase in FAT inhibition. Antibody co-labelling with the early-AD marker AT8 indicates that, similar to TOC1, TNT1 expression represents an early event in AD pathogenesis. Finally, the effects of the molecular chaperone Hsp70 (heat-shock protein 70) were also investigated within the squid axoplasm assay. We illustrate that Hsp70 preferentially binds to tau oligomers over filaments and prevents anterograde FAT inhibition observed with a mixture of both forms of aggregated tau. Together, these findings support the hypothesis that tau oligomers are the toxic form of tau in neurodegenerative disease.
Outcrop-behind Outcrop (Quarry)<subtitle>Multiscale Characterization of the Woodford Gas Shale, Oklahoma</subtitle> (2012)

In the early 1970s, most exploration geologists in the United States considered subeconomic or marginally economic petroleum resources such as coalbed methane, shale gas, and tight-gas sands as unconventional resources (Law and Curtis, 2002). Tax incentives and federally funded research beginning in the late 1970s helped make these resources economically viable in the last two decades of the 20th century. Economics aside, two important geologic attributes characterize most unconventional petroleum resources (Law and Curtis, 2002). Conventional petroleum systems are buoyancy-driven accumulations found in structural or stratigraphic traps, whereas most unconventional systems exist independent of a water column and are generally not found in structural or stratigraphic traps.Shale reservoirs are not new. The first commercial hydrocarbon production in the United States was from a well drilled in 1821 in a shale gas reservoir. By 2000, more than 28,000 wells had been drilled in shale gas reservoirs. Rising gas prices and technological advancements in horizontal drilling and hydraulic fracturing associated with the development of the Barnett Shale led to a boom in shale gas development in the early years of the 21st century. Now the exploitation of shale reservoirs is turning to natural gas liquids, condensate, and oil. Far from being isotropic and homogeneous, as once naively envisioned, shale reservoirs are complexly layered accumulations of fine-grained sediment. Geologic variation on scales ranging from that of stratal architecture to that of lamination within individual beds must be understood in order to locate and exploid areas of higher production within shale reservoirs. Shale reservoirs remain largely geologic plays - notmerely lease plays or strictly engineering plays made possible by improvements in drilling and completion technology.
Rare-earth-containing liquid crystals with Schiff base ligands (1999)

status: Published
Purification and physical properties of inducible Escherichia coli lysine decarboxylase (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurification and physical properties of inducible Escherichia coli lysine decarboxylaseDonna L. Sabo, Elizabeth A. Boeker, Breck Byers, Hannah Waron, and Edmond H. FischerCite this: Biochemistry 1974, 13, 4, 662–670Publication Date (Print):February 1, 1974Publication History Published online1 May 2002Published inissue 1 February 1974https://doi.org/10.1021/bi00701a005RIGHTS & PERMISSIONSArticle Views694Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) Get e-Alerts Get e-Alerts
Complete Sequencing of pNDM-HK Encoding NDM-1 Carbapenemase from a Multidrug-Resistant Escherichia coli Strain Isolated in Hong Kong (2011)

The genetic support of NDM-1 gene suggests that it has evolved through complex pathways. The association with broad host range plasmid and multiple mobile genetic elements explain its observed horizontal mobility in multiple bacterial taxa.
Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation. (1993)

Experimental induction of a polycystic ovarian syndrome (PCOS) in rodents by the administration of a single dose of estradiol valerate (EV) results in activation of the peripheral sympathetic neurons that innervate the ovary. This activation is evidenced by an increased capacity of ovarian nerve terminals to incorporate and release norepinephrine (NE), an increase in ovarian NE content, and a decrease in ovarian beta-adrenergic receptor number in the ovarian compartments receiving catecholaminergic innervation. The present experiments were undertaken to examine the functional consequences of this enhanced sympathetic outflow to the ovary. The steroidal responses of the gland to beta-adrenergic receptor stimulation and hCG were examined in vitro 60 days after EV administration, i.e. at the time when follicular cysts are well established. EV-treated rats exhibited a remarkable increase in ovarian progesterone and androgen responses to isoproterenol, a beta-adrenergic receptor agonist, with no changes in estradiol responsiveness. Basal estradiol release was, however, 50-fold higher than the highest levels released from normal ovaries at any phase of the estrous cycle. The ovarian progesterone and androgen responses to hCG were enhanced in EV-treated rats, as were the responses to a combination of isoproterenol and hCG. Transection of the superior ovarian nerve (SON), which carries most of the catecholaminergic fibers innervating endocrine ovarian cells, dramatically reduced the exaggerated responses of all three steroids to both beta-adrenergic and gonadotropin stimulation. SON transection also reduced the elevated levels of ovarian NE resulting from EV treatment and caused up-regulation of beta-adrenoreceptors. Most importantly, SON transection restored estrous cyclicity and ovulatory capacity. The results indicate that the increased output of ovarian steroids in PCOS is at least in part due to an enhanced responsiveness of the gland to both catecholaminergic and gonadotropin stimulation. The ability of SON transection to restore a normal response indicates that the alteration in steroid output results from a deranged activation of selective components of the noradrenergic innervation to the ovary. These findings support the concept that an alteration in the neurogenic control of the ovary contributes to the etiology of PCOS.
In Vitro Assessment of Dialysis Membrane as an Endotoxin Transfer Barrier: Geometry, Morphology, and Permeability (2008)

High-flux dialysis membranes used with bicarbonate dialysis fluid increase the risk of back diffusion of bacterial endotoxin into the blood during hemodialysis. Endotoxin transfer of various synthetic fiber membranes was tested with bacterial culture filtrates using an in vitro system testing both diffusive and convective conditions. Membranes were tested in a simulated dialysis mode with endotoxin challenge material (approximately 420 EU/mL) added to the dialysis fluid, with saline used to model both blood and dialysis fluid. Samples were taken of both blood and dialysis fluid, and analyzed using a kinetic turbidimetric Limulus amoebocyte lysate assay. Endotoxin was found in all of the blood circuit samples, except for the Fresenius Optiflux F200NR(e) and thick-wall membranes. All membranes tested removed approximately 95% of the endotoxin from solution, with the residual approximately 5% recirculating within the dialysis fluid compartment. Endotoxin distribution through the fiber membrane was examined using a fluorescent-labeled endotoxin conjugate. Fluorescence images indicate that adsorption occurs throughout the membrane wall, with the greatest concentration of endotoxin located at the inner lumen. Contact angle analysis was able to show that all membranes exhibit a more hydrophilic lumen and a more hydrophobic outer surface except for the polyethersulfone membranes, which were of equal hydrophobicity. Resulting data indicate that fiber geometry plays an important role in the ability of the membrane to inhibit endotoxin transfer, and that both adsorption and filtration are methods by which endotoxin is retained and removed from the dialysis fluid circuit.
Effect of iron chelators on proliferation and iron uptake in hepatoma cells (2001)

The results of the current study indicate that a number of different Fe chelators have the potential to treat HCC, and that further investigation into their mechanisms of action is warranted.
Androgen Receptor (AR), E-Cadherin, and Ki-67 as Emerging Targets and Novel Prognostic Markers in Triple-Negative Breast Cancer (TNBC) Patients (2015)

Our data suggest that the combination of AR and E-cadherin expression as well as Ki-67 status might be useful prognostic markers in TNBC. Hence, these molecular determinants could play an interesting role to classify subgroups of TNBC.
Synthesis of the bulky m-terphenyl phenol Ar*OH (Ar* = C6H3-2,6-Mes2, Mes = 2,4,6-trimethylphenyl) and the preparation and structural characterization of several of its metal complexes (2008)

The bulky m-terphenyl phenol Ar*OH 1 (Ar* = C 6 H 3 -2,6-Mes 2 , Mes = 2,4,6-trimethylphenyl) was synthesized via the treatment of Ar*Li with nitrobenzene. The phenol 1 is prepared in modest to good yield using this method. Attempts were also made to prepare 1 through oxidation of the bulky boronic acid Ar*B(OH) 2 with Oxone ® , but this reaction was not suitable for preparative-scale reactions. Side products of the reaction between Ar*Li and nitrobenzene were identified as Ar*[N(O)Ph] and [C 6 H 5 N(O)] 2 and were characterized by X-ray crystallography and EPR spectroscopy. A variety of main-group and transition-metal complexes of Ar*OH were prepared, namely Sn(OAr*) 2 , Ge(OAr*) 2 , [N(SiMe 3 ) 2 ]Ge(OAr*), [Me 2 Al(OAr*)] 2 , and Ti(NMe 2 )(OAr*) 2 . All compounds were characterized spectroscopically and most were studied by single-crystal X-ray diffraction as well.Key words: m-terphenyl, main-group compounds, X-ray crystallography, multinuclear NMR spectroscopy, EPR spectroscopy.
Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. (1990)

Defensins are cationic, cysteine-rich peptides (Mr = 3500-4000) found in the cytoplasmic granules of neutrophils and macrophages. These peptides possess broad antimicrobial activity in vitro against bacteria, fungi, tumor cells, and enveloped viruses, and they are believed to contribute to the "oxygen-independent" antimicrobial defenses of neutrophils and macrophages. Pathophysiologic studies in vitro have pointed to the plasma membrane as a possible target for the cytotoxic action of defensins. We report here that defensins form voltage-dependent, weakly anion-selective channels in planar lipid bilayer membranes, and we suggest that this channel-forming ability contributes to their antimicrobial properties observed in vitro.
Long-term ocular complications in aphakic versus pseudophakic eyes of children with juvenile idiopathic arthritis-associated uveitis (2010)

With maximum control of perioperative inflammation and intensive follow-up, the implantation of an intraocular lens in well-selected eyes of children with JIA-associated uveitis is not associated with an increased risk of ocular hypertension, secondary glaucoma, cystoid macular oedema and optic disc swelling and showed better visual results up to and including 7 years after cataract extraction.
Perceptual issues in augmented reality revisited (2010)

This paper provides a classification of perceptual issues in augmented reality, created with a visual processing and interpretation pipeline in mind. We organize issues into ones related to the environment, capturing, augmentation, display, and individual user differences. We also illuminate issues associated with more recent platforms such as handhelds or projector-camera systems. Throughout, we describe current approaches to addressing these problems, and suggest directions for future research.
E2A Acts in cis in G1 Phase of Cell Cycle to Promote Ig Gene Diversification (2009)

Rearranged Ig genes undergo diversification in sequence and structure initiated by the DNA deaminase, activation-induced deaminase. Ig genes must be transcribed for diversification to occur, but whether there are additional requirements for cis activation has not been established. Here we show, by chromatin immunoprecipitation, that the regulatory factor E2A associates with the rearranged Ig lambda(R) gene in the chicken DT40 B cell line, which performs constitutive Ig gene diversification. By analysis of a DT40 derivative in which polymerized lactose operator tags the rearranged lambda(R) gene, we show that E2A must function in cis to promote diversification and that stimulation of diversification in cis depends on the E2A activation domains. By direct imaging, we show that lambda(R)/E2A colocalizations are most prominent in G(1). We further show that expression of the E2A antagonist Id1 prevents lambda(R)/E2A colocalizations in G(1) and impairs diversification but not transcription of lambda(R). Thus, E2A acts in cis to promote Ig gene diversification, and G(1) phase is the critical window for E2A action.
670. Organic fluorine compounds. Part XXI. α-Fluorinated keto-compounds (1961)

E. D. Bergmann, S. Cohen, E. Hoffman and Z. Rand-Meir, J. Chem. Soc., 1961, 3452 DOI: 10.1039/JR9610003452