gebhart/patrepeval huggingface dataset:
Presenteeism: at work--but out of it. (2004)

Employers are beginning to realize that they face a nearly invisible but significant drain on productivity: presenteeism, the problem of workers' being on the job but, because of illness or other medical conditions, not fully functioning. By some estimates, the phenomenon costs U.S. companies over 150 billion dollars a year--much more than absenteeism does. Yet it's harder to identify. You know when someone doesn't show up for work, but you often can't tell when, or how much, poor health hurts on-the-job performance. Many of the health problems that result in presenteeism are relatively benign. Research in this emerging area of study focuses on such chronic or episodic ailments as seasonal allergies, asthma, headaches, depression, back pain, arthritis, and gastrointestinal disorders. The fact is, when people don't feel good, they simply don't perform at their best. Employees who suffer from depression may be fatigued and irritable--and, therefore, less able to work effectively with others. Those with migraine headaches who experience blurred vision and sensitivity to light, not to mention acute pain, probably have a hard time staring at a computer screen all day. A number of companies are making a serious effort to determine the prevalence of illnesses and other medical conditions that undermine job performance, calculate the related drop in productivity, and find cost-effective ways to combat that loss. Indeed, researchers have discovered that presenteeism-related declines in productivity sometimes can be more than offset by relatively small investments in screening, treatment, and education. So organizations may find that it pays to make targeted investments in employees' health care--by covering the cost of allergy medication, for instance, or therapy for depression.
Transparent High-Frequency Ultrasonic Transducer for Photoacoustic Microscopy Application (2020)

We report the development of an optically transparent high-frequency ultrasonic transducer using lithium niobate single-crystal and indium-tin-oxide electrodes with up to 90% optical transmission in the visible-to-near-infrared spectrum. The center frequency of the transducer was at 36.9 MHz with 33.9%, at -6 dB fractional bandwidth. The photoacoustic imaging capability of the fabricated transducer was also demonstrated by successfully imaging a resolution target and mouse-ear vasculatures in vivo, which were irradiated by a 532 nm pulse laser transmitted through the transducer.
Is the 5S RNA a primitive ribosomal sequence? (1985)

A tandemly arranged cluster of 55 RNA-like sequences in the middle of ribosomal 26S to 28S rRNAs from divergent eukaryotic organisms raises the possibility that the larger ribosomal RNAs were built up, at least in part, by gene amplification events and suggests an intriguing evolutionary relationship between the 55 rRNA and the larger rRNA molecules.
Apolipoprotein E and dementia in Parkinson disease: a meta-analysis. (2006)

The APOE epsilon4 allele appears to be associated with a higher prevalence of dementia in PD. Publication bias and heterogeneous source data may, however, confound this conclusion. Confirmatory studies that use standardized and validated diagnostic criteria for dementia in PD are needed.
Prostate cancer chemoprevention by silibinin: Bench to bedside (2006)

Prostate cancer (PCA) is the most invasive malignancy and second leading cause of cancer deaths in American males. One approach to reduce PCA incidence, growth and metastasis is prevention and intervention targeted towards mitogenic and survival signaling and cell-cycle regulation. This approach is based on the rationale that overexpression of receptor tyrosine kinases (RTKs) and/or non-receptor tyrosine kinases leads to persistent autocrine stimulation of malignant cells for deregulated cell-cycle progression and uncontrolled growth. PCA progression has also been associated with transition from a paracrine to an autocrine relationship between receptors and growth ligands as this malignancy progresses to an advanced androgen-independent aggressive stage. Together, these studies suggest that targeting RTK-mediated signaling pathways along with cell-cycle regulators could be a practical and translational approach for PCA prevention and intervention. Here, we provide evidence that a naturally occurring nontoxic flavanoid, silibinin, targets the epidermal growth factor receptor (EGFR), insulin-like growth factor-1 receptor (IGF-1R) and NF-kappaB (nuclear factor-kappa B) pathways in PCA. Furthermore, it modulates cell-cycle regulators, including cyclin-dependent kinases (CDKs), Cip/Kip and cyclins for its anticancer efficacy against PCA. Silibinin inhibits growth of PCA cells from human, mouse, and rat origins, and also suppresses human prostate tumor xenograft growth in nude mice. Silibinin also inhibits PCA growth in the transgenic adenocarcinoma of mouse prostate (TRAMP) mouse model. Now, silibinin has been entered into phase I/II clinical trials in human PCA patients where preliminary observations were suggestive of its further study in a larger base of the patient population.
pH Responsive Decomposable Layer-by-Layer Nanofilms and Capsules on the Basis of Tannic Acid (2005)

Tannic acid (TA) was assembled in alternation with two different polycations, strong poly(dimethyldiallylamide) (PDDA) and weak poly(allylamine) (PAH), using a layer-by-layer technique. Their deposition at different pH was confirmed by QCM, UV−vis spectroscopy, and surface charge measurements. TA/polyelectrolyte multilayer films and capsules have pH-dependent structural properties different from those of commonly used poly(styrenesulfonate)/poly(allylamine) (PSS/PAH) compositions. The lowest speed of TA/polycation multilayer dissolution was found at the conditions close to those used for film preparation. Permeability for fluorescein-labeled dextrans into tannic acid/polycation capsules with a five bilayer wall composition was investigated as a function of pH using confocal microscopy. It was found that minimal permeability occurs at pH 5−7 and maximal permeability at very high and very low pH, providing new opportunities for capsule loading as compared with an established procedure for PSS/PAH microcapsules. For TA/PDDA layers, less soluble films and less permeable capsules were obtained as compared with TA/PAH layers.
Semantic Image Synthesis with Spatially-Adaptive Normalization (2019)

We propose spatially-adaptive normalization, a simple but effective layer for synthesizing photorealistic images given an input semantic layout. Previous methods directly feed the semantic layout as input to the deep network, which is then processed through stacks of convolution, normalization, and nonlinearity layers. We show that this is suboptimal as the normalization layers tend to ``wash away'' semantic information. To address the issue, we propose using the input layout for modulating the activations in normalization layers through a spatially-adaptive, learned transformation. Experiments on several challenging datasets demonstrate the advantage of the proposed method over existing approaches, regarding both visual fidelity and alignment with input layouts. Finally, our model allows user control over both semantic and style. Code is available at https://github.com/NVlabs/SPADE .
Dendritic Initiators for “Living” Radical Polymerizations:  A Versatile Approach to the Synthesis of Dendritic-Linear Block Copolymers (1996)

The first use of polyether dendrons as macromolecular initiators for the controlled free radical polymerization of vinyl monomers has been demonstrated. Dendrons containing either a single benzylic TEMPO or halide functionality at their focal point have been used for the nitroxide mediated and atom transfer radical polymerizations, respectively. In both cases, hybrid dendritic-linear block copolymers with well-controlled molecular weights and low polydispersities can be obtained. The structure of the hybrid block copolymers is supported by SEC and spectral data. All the copolymers exhibit a single Tg, indicating that both blocks are miscible. Hybrid block copolymers difficult or impossible to prepare by previous techniques have been synthesized to demonstrate the versatility of this approach.
Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics (2012)

Measles virus (MeV) is the poster child for acute infection followed by lifelong immunity. However, recent work shows the presence of MeV RNA in multiple sites for up to 3 mo after infection in a proportion of infected children. Here, we use experimental infection of rhesus macaques to show that prolonged RNA presence is characteristic of primary infection. We found that viral RNA persisted in the blood, respiratory tract, or lymph nodes four to five times longer than the infectious virus and that the clearance of MeV RNA from blood happened in three phases: rapid decline coincident with clearance of infectious virus, a rebound phase with increases up to 10-fold, and a phase of slow decrease to undetectable levels. To examine the effect of individual host immune factors on MeV load dynamics further, we developed a mathematical model that expressed viral replication and elimination in terms of the strength of MeV-specific T-cell responses, antibody responses, target cell limitations, and immunosuppressive activity of regulatory T cells. Based on the model, we demonstrate that viral dynamics, although initially regulated by T cells, require antibody to eliminate viral RNA. These results have profound consequences for our view of acute viral infections, the development of prolonged immunity, and, potentially, viral evolution.
Noise-induced and age-related hearing loss interactions (2006)

Noise-induced hearing loss (NIHL) and age-related hearing loss (AHL, or presbycusis) are widespread health problems that will continue to increase as our society ages. NIHL and AHL often coexist in the same ear; however, the conditions under which they interact and the mechanisms by which they do so remain poorly understood. Inspired by epidemiological studies suggesting that noise-exposed ears age differently from nonexposed ears [Gates et al., ‘‘Logitudinal threshhold changes in people with audiometric notches,’’ Hear. Res. 141, 220–228 (2000)], we studied interactions between NIHL and AHL in mouse; an animal with a short life span, with intrastrain genetic homogeneity to minimize variability and with interstrain differences in vulnerability which can be exploited to probe mechanisms. Using such models, we have uncovered evidence that early noise exposure can have an ongoing influence on the nature and progression of an age-related hearing loss. The nature of this age-related hearing loss exacerbation is special; it can occur even in ears without permanent threshold shifts from the noise and leads to massive loss of spiral ganglion neurons despite intact hair cell populations. Findings have practical importance for investigations of NIHL in animal models, and may have implications for clinical practices allocating noise-induced and age-related components of hearing loss as strictly additive. [Work supported by NIH.]
Cell-surface bound complement regulatory activity is necessary for the in vivo survival of KDH-8 rat hepatoma. (1994)

The monoclonal antibody 5I2 recognizes and functionally inhibits a Crry-like complement regulator molecule on rat cells (corresponding to human decay accelerating factor and membrane cofactor protein activity). The inhibition of complement regulatory activity by 5I2 antibody results in complement deposition on rat cell membranes exposed to homologous complement. Two subclones of KDH-8 rat hepatoma were selected for the experiments; one expressing high (CrryH) and the second low (CrryL) amounts of Crry-like antigen. Both sublines grow in vivo in syngeneic rats, but at lower cell doses (< 10(5) cells/rat) the survival time of rats injected with CrryL cells is prolonged. Injection of tumour-bearing rats with 5I2 monoclonal antibody intraperitoneally did not influence the tumour growth. However, it resulted in 50% mortality within a few hours, accompanied by severe haemorrhage in the peritoneal cavity. Pretreatment of the tumour cells with 5I2 monoclonal antibody or its F(ab')2 fragment substantially increased the survival time of recipient rats. Even permanent survivors were found, indicating that cell membrane-associated complement regulatory activity, which provides protection against attack of homologous complement, is necessary for in vivo tumour growth.
Electrochemical Cycling‐Induced Spinel Formation in High‐Charge‐Capacity Orthorhombic LiMnO2 (1999)

spinel normally undergoes a transformation from its cubic to tetragonal phase when x exceeds 1 due to a collective Jahn‐Teller distortion, resulting in poor cyclability when both the 4 and 3 V intercalation plateaus are utilized. In this study, we show that this transformation is suppressed in spinels of composition up to x ≈ 2 obtained through the electrochemical cycling of orthorhombic . X‐ray diffraction, transmission electron microscopy, and high‐resolution electron microscopy studies together show that cycling produces a cubic spinel containing partial tetrahedral cation site occupancy and a nanodomain structure (20 to 50 nm size) within parent single‐crystalline oxide particles. This structure is responsible for the cycling stability of electrochemically produced spinel. The reversible capacity (272 mAh/g) and energy density (853 Wh/kg) achieved at a low charge‐discharge rate (3.33 mA/g) in the present samples are the highest among crystalline materials reported to date. © 1999 The Electrochemical Society. All rights reserved.
Advances and Future Challenges in Recombinant Adenoviral Vectored H5N1 Influenza Vaccines (2012)

The emergence of a highly pathogenic avian influenza virus H5N1 has increased the potential for a new pandemic to occur. This event highlights the necessity for developing a new generation of influenza vaccines to counteract influenza disease. These vaccines must be manufactured for mass immunization of humans in a timely manner. Poultry should be included in this policy, since persistent infected flocks are the major source of avian influenza for human infections. Recombinant adenoviral vectored H5N1 vaccines are an attractive alternative to the currently licensed influenza vaccines. This class of vaccines induces a broadly protective immunity against antigenically distinct H5N1, can be manufactured rapidly, and may allow mass immunization of human and poultry. Recombinant adenoviral vectors derived from both human and non-human adenoviruses are currently being investigated and appear promising both in nonclinical and clinical studies. This review will highlight the current status of various adenoviral vectored H5N1 vaccines and will outline novel approaches for the future.
Oligonucleotide Ligation Assay for Detecting Mutations in the Human Immunodeficiency Virus Type 1 pol Gene That Are Associated with Resistance to Zidovudine, Didanosine, and Lamivudine (1998)

This report describes the detection of mutations in the pol gene of human immunodeficiency virus type 1 associated with resistance to zidovudine, didanosine, and lamivudine by genotyping by an oligonucleotide ligation assay specific codons in the pol gene amplified by PCR. Our studies demonstrate the sensitivity, simplicity, and specificity of this genotyping system.
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6 (2007)

The R-Spondin (RSpo) family of secreted proteins act as potent activators of the Wnt/beta-catenin signaling pathway. We have previously shown that RSpo proteins can induce proliferative effects on the gastrointestinal epithelium in mice. Here we provide a mechanism whereby RSpo1 regulates cellular responsiveness to Wnt ligands by modulating the cell-surface levels of the coreceptor LRP6. We show that RSpo1 activity critically depends on the presence of canonical Wnt ligands and LRP6. Although RSpo1 does not directly activate LRP6, it interferes with DKK1/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 levels on the cell surface. Our results support a model in which RSpo1 relieves the inhibition DKK1 imposes on the Wnt pathway.
Novel mutation in the γ-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K–dependent blood coagulation factors (2000)

A mutation in the γ-glutamyl carboxylase gene leading to a combined congenital deficiency of all vitamin K-dependent coagulation factors was identified in a Lebanese boy. He is the first offspring of consanguineous parents and was homozygous for a unique point mutation in exon 11, resulting in the conversion of a tryptophan codon (TGG) to a serine codon (TCG) at amino acid residue 501. Oral vitamin K1 administration resulted in resolution of the clinical symptoms. Screening of several family members on this mutation with an RFLP technique revealed 10 asymptomatic members who were heterozygous for the mutation, confirming the autosomal recessive pattern of inheritance of this disease. In 50 nonrelated normal subjects, the mutation was not found. This is the second time a missense mutation in the γ-glutamyl carboxylase gene is described that has serious impact on normal hemostasis.
Endothelial modulation of myocardial contraction: mechanisms and potential relevance in cardiac disease (1992)

Recent studies in isolated cardiac preparations and the intact heart demonstrate that the endocardial and coronary vascular endothelium modulate myocardial contractile behaviour and cardiac pump function in a novel manner, mainly by influencing the duration of contraction and the onset of relaxation but without major effect on early systolic contractile characteristics. These effects are mediated by the release of at least two diffusible substances from endothelial cells: a) endothelium-derived relaxing factor (EDRF) which shortens contractile duration by elevating myocardial cyclic GMP, and b) a novel substance, provisionally named "endocardin", which prolongs contractile duration. Under physiological conditions these endothelial influences may be particularly important for relaxation and early diastolic filling events in the heart. It is possible that they could influence myocardial growth, interact with other cardiac hormones, and via EDRF inhibit platelet adhesion to endothelial surfaces. The release of the endothelial factors is regulated by stimuli such as circulating neurohumoral substances, increased flow, products of platelet aggregation, and endogenous peptides stored in endothelial cells. Although experimental evidence is still limited, it seems likely that cardiac endothelium may play an important role in the pathophysiology of cardiac disease, e.g. overload-induced hypertrophy. The endothelium could a) influence the development of phenotype change by modulating and mediating transduction of extrinsic signals, b) contribute to contractile and other abnormalities (especially "diastolic" dysfunction) because of loss or impairment of its normal function, and c) be uniquely amenable to therapeutically useful pharmacological manipulation.
Allergen‐induced increase in non‐allergic bronchial reactivity (1977)

Non-allergic bronchial hyper-reactivity is a feature of most patients with asthma. We have measured non-allergic bronchial reactivity to inhaled histamine and methacholine in thirteen asthmatic subjects before and after allergen inhalation in the laboratory. The allergen inhalation produced mild early asthmatic responses (19-40% FEV1 fall) in all thirteen, additional definite late asthmatic responses (17-29% FEV1 fall) in four, and equivocal late asthmatic responses (5-11% FEV1 fall) in five. Following allergen inhalation, non-allergic bronchial reactivity increased in seven for up to 7 days. The seven included all four with definite late asthmatic responses and three of the five with equivocal late asthmatic responses. We conclude that allergens make asthma worse, partly through non-allergic mechanisms, and that avoidance of allergens is important in reducing non-allergic bronchial hyper-reactivity.
Four-component condensation: a new versatile method for the synthesis of substituted prolyl peptides (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour-component condensation: a new versatile method for the synthesis of substituted prolyl peptidesRuth F. Nutt and Madeleine M. JoullieCite this: J. Am. Chem. Soc. 1982, 104, 21, 5852–5853Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/ja00385a080https://doi.org/10.1021/ja00385a080research-articleACS PublicationsRequest reuse permissionsArticle Views615Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Small eye (Sey): a mouse model for the genetic analysis of craniofacial abnormalities (1988)

Small eye (Sey) is a dominant mutation in the mouse affecting the embryonic development of the eyes and nose. In homozygous Sey/Sey embryos, the optic vesicles grow out but there is no lens induction and the nasal pits fail to develop. Scanning electron microscope studies of Sey/Sey embryos show that the maxillary processes develop normally and fuse with ridges of ectoderm in the frontonasal position. In Sey/+ heterozygotes, the vacuolated lens is smaller than normal, and there is folding of the margins of the optic cup and ingrowth of mesodermal cells. Evidence is presented that Sey is not allelic with Coloboma (Cm), another mutation affecting eye development on chromosome 2.
Facile synthesis of AB2‐type miktoarm star polymers through the combination of atom transfer radical polymerization and ring‐opening polymerization (2004)

Abstract A novel miktofunctional initiator ( 1 ), 2‐hydroxyethyl 3‐[(2‐bromopropanoyl)oxy]‐2‐{[(2‐bromopropanoyl)oxy]methyl}‐2‐methyl‐propanoate, possessing one initiating site for ring‐opening polymerization (ROP) and two initiating sites for atom transfer radical polymerization (ATRP), was synthesized in a three‐step reaction sequence. This initiator was first used in the ROP of ϵ‐caprolactone, and this led to a corresponding polymer with secondary bromide end groups. The obtained poly(ϵ‐caprolactone) (PCL) was then used as a macroinitiator for the ATRP of tert ‐butyl acrylate or methyl methacrylate, and this resulted in AB 2 ‐type PCL–[poly( tert ‐butyl acrylate)] 2 or PCL–[poly(methyl methacrylate)] 2 miktoarm star polymers with controlled molecular weights and low polydispersities (weight‐average molecular weight/number‐average molecular weight &lt; 1.23) via the ROP–ATRP sequence. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 2313–2320, 2004