gebhart/patrepeval huggingface dataset:
First-principles calculations of the electronic structure and spectra of strongly correlated systems: theLDA+Umethod (1997)

A generalization of the local density approximation (LDA) method for systems with strong Coulomb correlations is described which gives a correct description of the Mott insulators. The LDA+U method takes into account orbital dependence of the Coulomb and exchange interactions which is absent in the LDA. The scheme can be regarded as a `first-principles' method because there are no adjustable parameters. When applied to the transition metal and rare-earth metal compounds, the LDA+U method gives a qualitative improvement compared with the LDA not only for excited-state properties such as energy gaps but also for ground-state properties such as magnetic moments and interatomic exchange parameters. The orbital-dependent rotationally invariant LDA+U potential gives a correct orbital polarization and a corresponding Jahn - Teller distortion as well as polaron formation.
Piezoresistive Strain Sensors and Multiplexed Arrays Using Assemblies of Single-Crystalline Silicon Nanoribbons on Plastic Substrates (2011)

This paper describes the fabrication and properties of flexible strain sensors that use thin ribbons of single-crystalline silicon on plastic substrates. The devices exhibit gauge factors of 43, measured by applying uniaxial tensile strain, with good repeatability and agreement with expectation based on finite-element modeling and literature values for the piezoresistivity of silicon. Using Wheatstone bridge configurations integrated with multiplexing diodes, these devices can be integrated into large-area arrays for strain mapping. High sensitivity and good stability suggest promise for the various sensing applications.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. (1993)

We report here the use of the 5' flanking region of the murine tyrosinase gene to direct expression of the herpes simplex virus thymidine kinase (tk) gene specifically to murine melanoma cells, whilst not permitting expression in a range of other cell types. Expression of the herpes simplex virus tk gene from the tyrosinase promoter in melanoma cells rendered them sensitive to killing by ganciclovir (100% cell death of a tk-expressing B16 clone after 12 days in culture at 1 microgram/ml ganciclovir). We also observed a substantial bystander killing effect when expressing cells were mixed with nontransfected parental B16 cells. When transfected murine melanoma cells expressing tk were injected into syngeneic mice both their tumorigenicity and experimental metastatic potential were abrogated completely when the mice were treated with ganciclovir (27 of 28 mice treated with water developed progressively growing tumors versus 1 of 30 in the ganciclovir-treated group). Direct injection of the tk gene under control of the tyrosinase promoter into established tumors in mice, followed by treatment with ganciclovir, led to significant reductions in resultant tumor size relative to the size of tumor developing in mice treated with water (median tumor weight, 1.65 g versus 2.75 g). Therefore, direct transfer of recombinant genes by injection of DNA can significantly reduce established tumor burden in vivo.
Graphene-containing thermoresponsive nanocomposite hydrogels of poly(N-isopropylacrylamide) prepared by frontal polymerization (2011)

Frontal polymerization has been successfully used to synthesize poly(N-isopropylacrylamide) nanocomposite hydrogels containing graphene. The latter was directly achieved by ultrasound treatment of a dispersion of graphite in N-methylpyrrolidone. The dispersion, having the concentration of 2.21 g L−1, was characterized by TEM analysis and mixed with suitable amounts of N-isopropylacrylamide for the synthesis of graphene-containing nanocomposite polymer hydrogels. The nanocomposite hydrogels were analyzed by SEM and Raman spectroscopy, and their swelling and rheological properties were investigated. It was found that graphene strongly influences the swelling ratio, dramatically increasing it, even if present in small amounts. Finally, the rheological properties of the hydrogels were correlated with the graphene content: G′ modulus and complex viscosity were found to increase with increasing nanofiller concentration, thus indicating the occurrence of good interactions between the two phases. Nevertheless, at a high concentration (i.e., 0.13 wt.%), graphene showed a lubrication effect, lowering the rheological parameters and approaching the same pseudoplastic behaviour of the unfilled material.
C-Nor-D-homosteroids and related alkaloids. IX. Synthesis of jervine and related alkaloids (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTC-Nor-D-homosteroids and related alkaloids. IX. Synthesis of jervine and related alkaloidsTadashi. Masamune, Mitsuo. Takasugi, Akio. Murai, and Kiroku. KobayashiCite this: J. Am. Chem. Soc. 1967, 89, 17, 4521–4523Publication Date (Print):August 1, 1967Publication History Published online1 May 2002Published inissue 1 August 1967https://pubs.acs.org/doi/10.1021/ja00993a048https://doi.org/10.1021/ja00993a048research-articleACS PublicationsRequest reuse permissionsArticle Views817Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria (2006)

Toll-like receptors (TLRs) are key components of the immune system that detect microbial infection and trigger antimicrobial host defense responses. TLR5 is a sensor for monomeric flagellin, which is a component of bacterial flagella known to be a virulence factor. In this study we generated TLR5-deficient mice and investigated the role of TLR5 signaling in the detection of flagellin and antibacterial immune responses to Salmonella typhimurium and Pseudomonas aeruginosa. We found that TLR5 is essential for the recognition of bacterial flagellin both in vivo and ex vivo. TLR5 contribution to antibacterial host response to i.p. infection with S. typhimurium or intranasal administration of P. aeruginosa may be masked by TLR4 or other sensing mechanisms. By using radiation bone marrow chimera, we showed that upon i.p. injection of flagellin immune responses are mediated by lymphoid cells, whereas resident cells are required for the initiation of response upon intranasal flagellin administration. These results suggest that flagellin recognition in different organs is mediated by distinct TLR5-expressing cells and provide insights into the cooperation of the TLR5 and TLR4 signaling pathways used by the innate immune system in the recognition of bacterial pathogens.
Securing ad hoc routing protocols (2002)

We consider the problem of incorporating security mechanisms into routing protocols for ad hoc networks. Canned security solutions like IPSec are not applicable. We look at AODV[21] in detail and develop a security mechanism to protect its routing information. We also briefly discuss whether our techniques would also be applicable to other similar routing protocols and about how a key management scheme could be used in conjunction with the solution that we provide.
Psychiatric syndromes in Huntington's disease (1983)

Thirty patients with Huntington's disease, a genetically transmitted neuropsychiatric disorder that can be diagnosed reliably, were evaluated systematically for psychopathology, followed for extended periods, and treated with psychopharmacological medications when necessary. DSM-III criteria were used for establishing syndromic diagnoses. Twenty-four individuals demonstrated substantial behavioral abnormalities, including affective and schizophrenic syndromes, changes of personality, and disorders that could not be classified adequately. Pharmacotherapy was modestly beneficial in some cases. Consideration of the array of behavioral disturbances encountered in this pathogenetically unified disorder suggests that a dimensional approach to symptom classification might prove more useful heuristically than present typological methods.
Gd‐DTPA‐polylysine—enhanced pulmonary time‐of‐flight MR angiography (1994)

The enhancing effect of gadolinium diethylenetriaminepentaacetic acid (DTPA) polylysine (a macromolecular paramagnetic contrast agent) in time-of-flight magnetic resonance (MR) angiography of isolated perfused sheep lungs was studied. Unilateral lung damage was induced with hydrochloric acid in eight sheep. The heart and lungs were removed from the thoracic cavity, and after cannulation of the trachea and both ventricles, pulsatile perfusion and ventilation were initiated. The heart-lung preparations were placed in the head coil of a 1.5-T imager. Time-of-flight pulmonary MR angiography was performed during respiratory arrest, before and after administration of 0.02 mmol/kg Gd-DTPA-polylysine. On the postcontrast angiograms, the signal intensity increased by 120% in pulmonary arteries (P < .01). The contrast-to-noise ratio between pulmonary arteries and parenchyma increased significantly (P < .01). The number of visualized generations of pulmonary artery branches increased from four to six in normal lungs and from three to five in edematous lungs. Low-dose Gd-DTPA-polylysine significantly improves the conspicuity of the pulmonary vascular tree in time-of-flight pulmonary MR angiography.
Bone Affinity of a Bisphosphonate-Conjugated Protein in Vivo (2000)

Growth factors capable of stimulating bone formation are potential therapeutic agents for osteoporosis treatment. It is essential, however, that a targeting mechanism is incorporated into the growth factors to deposit them at osseous tissue with minimal distribution to extraskeletal sites. To this end, a strategy has been developed in which a bone-seeking molecule, 1-amino-1,1-diphosphonate methane (aminoBP), was chemically conjugated to a model protein, bovine serum albumin (BSA). This study was carried out to assess the bone affinity of the conjugates in a tibia injection model. Using ovariectomized (OVX) rats, initial (3 h) retention of BSA and aminoBP-BSA were found to be equivalent when injected into the medullary cavity of tibia. After 1 day, an 8- and 12-fold higher tibiae retention of the protein was obtained in normal and OVX rats as a result of aminoBP conjugation. A similar result ( approximately 12-fold difference) was also obtained in OVX rats after 3 days. We concluded that aminoBP conjugation to BSA imparted a high bone affinity and enhanced bone retention of proteins in normal and OVX rats.
Real-time monocular SLAM: Why filter? (2010)

While the most accurate solution to off-line structure from motion (SFM) problems is undoubtedly to extract as much correspondence information as possible and perform global optimisation, sequential methods suitable for live video streams must approximate this to fit within fixed computational bounds. Two quite different approaches to real-time SFM - also called monocular SLAM (Simultaneous Localisation and Mapping) - have proven successful, but they sparsify the problem in different ways. Filtering methods marginalise out past poses and summarise the information gained over time with a probability distribution. Keyframe methods retain the optimisation approach of global bundle adjustment, but computationally must select only a small number of past frames to process. In this paper we perform the first rigorous analysis of the relative advantages of filtering and sparse optimisation for sequential monocular SLAM. A series of experiments in simulation as well using a real image SLAM system were performed by means of covariance propagation and Monte Carlo methods, and comparisons made using a combined cost/accuracy measure. With some well-discussed reservations, we conclude that while filtering may have a niche in systems with low processing resources, in most modern applications keyframe optimisation gives the most accuracy per unit of computing time.
Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines. (1988)

The loss of bands p21-22 from one chromosome 9 homologue as a consequence of a deletion of the short arm [del(9p)], unbalanced translocation, or monosomy 9 is frequently observed in the malignant cells of patients with lymphoid neoplasias, including acute lymphoblastic leukemia and non-Hodgkin lymphoma. The alpha- and beta 1-interferon genes have been assigned to this chromosome region (9p21-22). We now present evidence of the homozygous deletion of the interferon genes in neoplastic hematopoietic cell lines and primary leukemia cells in the presence or absence of chromosomal deletions that are detectable at the level of the light microscope. In these cell lines, the deletion of the interferon genes is accompanied by a deficiency of 5'-methylthioadenosine phosphorylase (EC 2.4.2.28), an enzyme of purine metabolism. These homozygous deletions may be associated with the loss of a tumor-suppressor gene that is involved in the development of these neoplasias. The relevant genes may be either the interferon genes themselves or a gene that has a tumor-suppressor function and is closely linked to them.
Low‐Temperature, Surface‐Mediated Foaming of Polymer Films (2004)

Ultraporous thin polymer films (see Figure) are generated using physical constraints imposed by external surfaces (hard plates) and internal surfaces (hard nanoparticles and soft micelles) via foaming with supercritical CO 2 . The constraints serve as diffusion barriers and/or heterogeneous nucleation sites. Use of CO 2 ‐philic copolymers further enables microcellular foaming at reduced pressures with liquid CO 2 .
Identification of an Antigenic and Genetic Variant of Dengue-4 Virus from the Caribbean (1986)

Twenty-one dengue (DEN) viruses isolated from the Caribbean (Dominica and Jamaica) during the 1981-1982 epidemic year were distinct serological and genetic variants of DEN-4 virus. These isolates were clearly identified as DEN-4 viruses using type-specific monoclonal antibodies in indirect immunofluorescence assays. However, they either were not neutralized, or were neutralized poorly using hyperimmune mouse ascitic fluids (HMAF) or rhesus monkey serum directed against the H-241 prototype strain of DEN-4 virus isolated in the Philippines in 1956. HMAF prepared against a representative Caribbean isolate, however, neutralized with similar effectiveness the homologous virus, the H-241 prototype strain, and virus strains isolated from the Pacific and Southeast Asian areas from 1973 to 1984. The Caribbean isolate exhibited no more than 30% and 16% oligonucleotide spot homology with the H-241 and Bangkok viruses, respectively, by RNA fingerprint analysis, while demonstrating 82% and 89% homology with the Gilbert and Niue Island isolates, respectively. The isolation of dengue viruses which are serologically and genetically distinct from the prototype virus emphasizes the need for continued dengue virus surveillance. The recognition of unique dengue isolates should allow the selection of reference strains and vaccine candidate strains which will induce antibodies that are equally effective in neutralizing viruses from all geographic areas.
High Purity Sulfur from Smelter Gases (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh Purity Sulfur from Smelter GasesEdward P. Fleming and T. Cleon FittCite this: Ind. Eng. Chem. 1950, 42, 11, 2249–2253Publication Date (Print):November 1, 1950Publication History Published online1 May 2002Published inissue 1 November 1950https://pubs.acs.org/doi/10.1021/ie50491a027https://doi.org/10.1021/ie50491a027research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Specification of management policies and discretionary access control (1994)

This chapter is concerned with the specification of management policy. Its aim is to treat policies in a general manner, but discretionary access control policies are used as an example, to illustrate how they are specified and what the major issues are. It consists of four sections. Section 17.1 gives the background and motivation for this subject and sets out a general model of management policies. It explains the need to model policies, their general characteristics, and their representation as objects so that they can be created, modified and queried. There are a number of possible relationships between policies, either hierarchical or potentially conflicting, and a brief analysis of this incompletely researched area is provided. A well-understood example of a management policy is the access rule, used to specify discretionary access control policies. Section 17.2 introduces and explains access rules. A short example shows their practical effect, and the implementation issues are discussed. In Section 17.3 delegation of authority, the means by which access rule
EUV optical design for a 100-nm CD imaging system (1998)

The imaging specifications for extreme ultraviolet lithography (EUVL) projection optics parallel those of other optical lithographies. Specifications are scaled to reflect the 100 nm critical dimension for the first generation EUVL systems. The design being fabricated for the Engineering Test Stand, an EUVL alpha tool, consists of a condenser with six channels to provide an effective partial coherence factor of 0.7. The camera contains four mirrors; three of the mirrors are aspheres and the fourth is spherical. The design of the optical package has been constrained so that the angles of incidence and the variations in the angle of incidence of all rays allow for uniform multilayer coatings. The multilayers introduce a slight shift in image position and magnification. We have shown that a system aligned with visible light is also aligned at 13.4 nm. Each mirror must be fabricated with an RMS figure error of less than 0.25 nm and better than 0.2 nm RMS roughness. Optical surfaces that exceed each of these specifications individually have been fabricated. The success of EUVL requires that these specifications be met simultaneously. Keywords: EUV projection lithography, optical design, multilayer coatings, aspheric optics
Human BLyS Facilitates Engraftment of Human PBL Derived B Cells in Immunodeficient Mice (2008)

The production of fully immunologically competent humanized mice engrafted with peripheral lymphocyte populations provides a model for in vivo testing of new vaccines, the durability of immunological memory and cancer therapies. This approach is limited, however, by the failure to efficiently engraft human B lymphocytes in immunodeficient mice. We hypothesized that this deficiency was due to the failure of the murine microenvironment to support human B cell survival. We report that while the human B lymphocyte survival factor, B lymphocyte stimulator (BLyS/BAFF) enhances the survival of human B cells ex vivo, murine BLyS has no such protective effect. Although human B cells bound both human and murine BLyS, nuclear accumulation of NF-kappaB p52, an indication of the induction of a protective anti-apoptotic response, following stimulation with human BLyS was more robust than that induced with murine BLyS suggesting a fundamental disparity in BLyS receptor signaling. Efficient engraftment of both human B and T lymphocytes in NOD rag1(-/-) Prf1(-/-) immunodeficient mice treated with recombinant human BLyS is observed after adoptive transfer of human PBL relative to PBS treated controls. Human BLyS treated recipients had on average 40-fold higher levels of serum Ig than controls and mounted a de novo antibody response to the thymus-independent antigens in pneumovax vaccine. The data indicate that production of fully immunologically competent humanized mice from PBL can be markedly facilitated by providing human BLyS.
An Algorithmic Computer Graphics Program for Generating Chemical Structure Diagrams (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Algorithmic Computer Graphics Program for Generating Chemical Structure DiagramsPaul G. Dittmar, Joseph Mockus, and Kathyrn M. CouvreurCite this: J. Chem. Inf. Comput. Sci. 1977, 17, 3, 186–192Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/ci60011a015https://doi.org/10.1021/ci60011a015research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts