gebhart/patrepeval huggingface dataset:
Bio FEDs (Field‐Effect Devices): State‐of‐the‐Art and New Directions (2006)

Abstract This paper gives a brief survey on biologically sensitive FEDs (field‐effect devices) and introduces some recent approaches in this field. Basic concepts, functional principles and current trends in research and development for namely, ISFETs (ion‐sensitive field‐effect transistors), capacitive EIS (electrolyte‐insulator‐semiconductor) sensors and LAPS (light‐addressable potentiometric sensor) structures will be presented.
Conservation of Structure and Function Between Human and Murine IL-16 (1998)

IL-16 is a proinflammatory cytokine that signals via CD4, inducing chemotactic and immunomodulatory responses of CD4+ lymphocytes, monocytes, and eosinophils. Comparative analysis of murine and human IL-16 homologs could reveal conserved structures that would help to identify key functional regions of these cytokines. To that end, we cloned the murine IL-16 cDNA and found a high degree of amino acid similarity comparing the predicted murine and human IL-16 precursor proteins (pro-IL-16). The highest similarity (82.1%) was found in the C-terminal region, which is cleaved from pro-IL-16 to yield biologically active IL-16. Chemotaxis experiments with IL-16 of murine and human origin, using murine splenocytes or human T lymphocytes as targets, showed cross-species stimulation of motility. Synthetic oligopeptides and anti-peptide Ab were produced, based on the sequences of three predicted hydrophilic domains of IL-16 potentially presented in exposed positions. None of these peptides had intrinsic IL-16 bioactivity, but one (corresponding to a hydrophilic C-terminal domain of IL-16) partially displaced binding of OKT4 mAb to human lymphocytes. This peptide, and its cognate Ab, also inhibited IL-16 chemoattractant activity for human and murine cells. These studies demonstrate a high degree of structural and functional similarity between human and murine IL-16 and suggest that amino acids in the C terminus are critical for its chemoattractant function. The data suggest cross-species conservation of IL-16 receptor structures as well. Inhibitory peptides may be useful in disease states where the proinflammatory functions of IL-16 are detrimental to the host.
Overexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma (2014)

PI4KA mRNA could be used as a new molecular marker to improve established prognostic models for HCC. These findings also indicate possible new lines of research for the development of innovative therapeutic approaches targeting PI4KA.
Selective epitaxial growth of GaAs on Si with strained short-period superlattices by molecular beam epitaxy under atomic hydrogen irradiation (2004)

Selective epitaxial growth of GaAs on a Si substrate with (GaAs)m(GaP)n strained short-period superlattices (SSPSs) and GaP buffer layer was achieved by molecular beam epitaxy under atomic hydrogen irradiation. The selective epitaxial layers were grown two dimensionally so that reflection high-energy electron diffraction patterns maintained streaky patterns with no apparent transition to three-dimensional spot patterns during the selective epitaxial growth of the GaAs/SSPSs/GaP/Si structure. Therefore, generation of threading dislocations due to the three-dimensional island growth was suppressed, in spite of a large lattice mismatch. It was also confirmed that the thickness of each buffer layer was slightly increased near the edge of the masked region. Finally, the epitaxial patterns of GaAs clearly exhibit crystal facets.
Using Logical Observation Identifier Names and Codes (LOINC) to exchange laboratory data among three academic hospitals. (1997)

Using a standard set of names and codes to exchange electronic laboratory data would facilitate multiinstitutional research and data pooling. This need has led to the development of the Logical Observation Identifier Names and Codes (LOINC) database and its test naming convention. We conducted a study which required 3 academic hospitals (in 2 separate medical centers) to extract raw laboratory data from their local information system for a defined patient population, translate tests into LOINC, and provide aggregate data which could then be used to compare laboratory utilization. We found that the coding of local tests into LOINC can often be complex, especially the "Kind of Property" field, and apparently trivial differences in choices made by individual institutions can result in nonmatches in electronically pooled data. In our study, 72-86% of the failures of LOINC to match the same tests between different institutions were due to differences in local coding choices. LOINC has tremendous potential to eliminate the needing for detailed human inspection during the pooling of laboratory data from diverse sites, and perhaps even a built-in capability to adjust matching stringency by selecting subsets of LOINC fields required to match. However, a quality, standard coding procedure at all sites is critical.
A review of electronic portal imaging devices (EPIDs) (1992)

On-line electronic portal imaging devices are beginning to come into clinical service in support of radiotherapy. A variety of technologies are being explored to provide real-time or near real-time images of patient anatomy within x-ray fields during treatment on linear accelerators. The availability of these devices makes it feasible to verify treatment portals with much greater frequency and clarity than with film. This article reviews the physics of high-energy imaging and describes the operation principles of the electronic portal imaging devices that are under development or are beginning to be used clinically.
Experimental determination of compound action potential direction and propagation velocity from multi-electrode nerve cuffs (2004)

Information extracted from whole-nerve electroneurograms, recorded using electrode cuffs, can provide signals to neuroprostheses. However, the amount of information that can be extracted from a single tripole is limited. This communication demonstrates how previously unavailable information about the direction of action potential propagation and velocity can be obtained using a multi-electrode cuff and that the arrangement acts as a velocity-selective filter. Results from in vitro experiments on frog nerves are presented.
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a β-N-acetylglucosaminidase and not a hyaluronidase (2006)

Group A streptococcus (Streptococcus pyogenes) is the causative agent of severe invasive infections such as necrotizing fasciitis (the so-called 'flesh eating disease') and toxic-shock syndrome. Spy1600, a glycoside hydrolase from family 84 of the large superfamily of glycoside hydrolases, has been proposed to be a virulence factor. In the present study we show that Spy1600 has no activity toward galactosaminides or hyaluronan, but does remove beta-O-linked N-acetylglucosamine from mammalian glycoproteins--an observation consistent with the inclusion of eukaryotic O-glycoprotein 2-acetamido-2-deoxy-beta-D-glucopyranosidases within glycoside hydrolase family 84. Proton NMR studies, structure-reactivity studies for a series of fluorinated analogues and analysis of 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline as a competitive inhibitor reveals that Spy1600 uses a double-displacement mechanism involving substrate-assisted catalysis. Family 84 glycoside hydrolases are therefore comprised of both prokaryotic and eukaryotic beta-N-acetylglucosaminidases using a conserved catalytic mechanism involving substrate-assisted catalysis. Since these enzymes do not have detectable hyaluronidase activity, many family 84 glycoside hydrolases are most likely incorrectly annotated as hyaluronidases.
Isolation and characterization of a human monoclonal antibody which reacts with breast and colorectal carcinoma. (1991)

A human monoclonal antibody with specificity for breast and colorectal carcinoma has been isolated after hybridoma formation between regional lymph node lymphocytes from a patient with breast carcinoma and a mouse x human heteromyeloma (SPAZ-4). The monoclonal, MAB 15.2.3, is an IgM, kappa, which binds to an epitope found on at least four glycoproteins with approximate molecular weights of 37, 39, 43 and 56 kilodaltons (kD). These antigens are expressed intracellularly and on the surface of breast and colorectal carcinoma cells and their level of expression is increased by treatment with recombinant human leukocyte (IFN-alpha A) or immune (IFN-gamma) interferon. Analysis of formalin-fixed tumor cell lines indicates specificity for carcinomas. Similarly, immunostaining of paraffin-embedded tissue indicates both cell membrane and intracytoplasmic reactivity with breast (8 of 12), colorectal (3 of 4) and prostate (1 of 3) carcinomas. By employing a series of enzymes which specifically cleave sugar residues on proteins, it was demonstrated that the binding of MAB 15.2.3 could be increased. These observations suggest that the epitope recognized by MAB 15.2.3. is protein in nature and expressed on a series of glycoproteins. Pretreatment of Colo 205 (human colorectal carcinoma) cells with MAB 15.2.3 prior to implantation into nude mice, results in a reduction in the size and weight of tumors. With appropriate genetic engineering, resulting in the conversion of this antibody to an IgG, MAB 15.2.3. could prove of value for the diagnosis and ultimately the therapy of human breast and colorectal carcinomas.
RNA‐guided endonuclease – in situ labelling (RGEN‐ISL): a fast CRISPR/Cas9‐based method to label genomic sequences in various species (2019)

Visualising the spatio-temporal organisation of the genome will improve our understanding of how chromatin structure and function are intertwined. We developed a tool to visualise defined genomic sequences in fixed nuclei and chromosomes based on a two-part guide RNA with a recombinant Cas9 endonuclease complex. This method does not require any special construct or transformation method. In contrast to classical fluorescence in situ hybridiaztion, RGEN-ISL (RNA-guided endonuclease - in situ labelling) does not require DNA denaturation, and therefore permits a better structural chromatin preservation. The application of differentially labelled trans-activating crRNAs allows the multiplexing of RGEN-ISL. Moreover, this technique is combinable with immunohistochemistry. Real-time visualisation of the CRISPR/Cas9-mediated DNA labelling process revealed the kinetics of the reaction. The broad range of adaptability of RGEN-ISL to different temperatures and combinations of methods has the potential to advance the field of chromosome biology.
Intravaginal Slingplasty (IVS): An Ambulatory Surgical Procedure for Treatment of Female Urinary Incontinence (1995)

A new ambulatory procedure for treatment of female urinary incontinence (intravaginal slingplasty, IVS) was performed on 50 patients. In all patients the surgical procedure was carried out under local anaesthesia and without postoperative urinary catheterization. The technique has been elaborated from previous experimental and clinical studies and aims at restoration of the pubourethral ligament and the suburethral vaginal hammock. Thirty-eight patients suffered from genuine stress incontinence as objectively verified and 12 patients had symptoms and signs of both urge and stress incontinence. Thirty-nine (78%) patients were completely cured from their stress incontinence symptoms. Another six patients (12%) reported a considerable improvement of their urinary incontinence leaking only occasionally. Concerning urge incontinence symptoms a significant relief of the symptoms was obtained in 6 of 12 patients. No intra- or post-operative complications occurred.
In Vivo Assembly of Overproduced DNA Polymerase III (1996)

The genes for the polymerase core (alphaepsilontheta) of the DNA polymerase III holoenzyme map to widely separated loci on the Escherichia coli chromosome. To enable efficient overproduction and in vivo assembly of DNA polymerase III core, artificial operons containing the three structural genes, dnaE, dnaQ, and holE, were placed in an expression plasmid. The proteins alpha, alphaepsilon and alphaepsilontheta were overexpressed and assembled in E. coli and purified to homogeneity. The three purified polymerases had a similar specific activity of about 6.0 x 10(6) units/mg in a gap-filling assay. Kinetics studies showed that neither epsilon nor theta influenced the Km of alpha for deoxynucleotide triphosphate and only slightly decreased the Km of alpha for DNA, although epsilon was absolutely required for maximal DNA synthesis. The rate of DNA synthesis by alpha-reconstituted holoenzyme using tau complex was about 5-fold less than that of alphaepsilon or alphaepsilontheta-reconstituted holoenzyme as determined by a gel analysis. The processivity of alpha-reconstituted holoenzyme was very similar to that of alphaepsilontheta-reconstituted holoenzyme when tau complex was used as a clamp loader.
Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low levels of vitamin A. (1973)

Summary Induction of intestinal tumors by intragastric administration of 1,2-dimethylhydrazine (DMH) was studied in rats fed a semisynthetic diet containing either high, adequate, or low levels of vitamin A. Sixty to 100% of the treated rats had intestinal carcinoma 6 months after administration of the first dose of DMH. Total doses in amounts ranging from 195 to 420 mg/kg did not affect tumor incidence; however, rats given the largest total dose in the largest individual doses (30 mg/kg) developed more tumors in the colon than in other sites. Tumors were polypoid or intramural adenocarcinomas, of which a variable number produced mucus. In many cases they caused passage of bloody stools, intestinal obstruction, and/or intussusception. Tumor incidence and morphology were in all ways comparable to those reported in studies in which DMH was administered s.c. A high level of vitamin A in the diet (sufficient to raise the vitamin content in the serum and liver and reduce growth) did not change the incidence of colon tumors but decreased the number of tumors per rat at the highest DMH dose. Chronic dietary deficiency of vitamin A increased the incidence of tumors slightly and may have reduced induction time.
3, 5-Propanopiperidine Derivatives as Potential Analgesics (1974)

4β-Methoxy-4α-phenyl-3α, 5α-propanopiperidine derivatives were prepared and tested biologically. Introduction of a m-hydroxy substituent into the phenyl group of these derivatives results in radical potentiation of analgesic and antitussive activities. Also, some N-carbamates of these derivatives exhibit appreciable anti-inflammatory effects with analgesic activity.
Detecting Feature Interactions in Home Appliance Networks (2008)

Home appliance networks now have the capability of integrating different features of independent appliances to provide value-added services. Concurrent execution of these services, however, can cause unexpected problems, even when each service is independently correct. This paper addresses the issue of detecting such interactions between services. We propose an approach that consists of two steps. In the first step, a model is developed to capture the behavior of the services and the interactions between them and users. In the second step, the model is automatically analyzed to see if possible interactions exist. This automatic analysis can be effectively performed with model checking techniques. The usefulness of the proposed approach is demonstrated through a case study, where several interactions were successfully detected.
Reactions of hydrosilanes and olefins in the presence of Cp2MCl2/BuLi (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of hydrosilanes and olefins in the presence of Cp2MCl2/BuLiJoyce Y. Corey and Xiao Hong ZhuCite this: Organometallics 1992, 11, 2, 672–683Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/om00038a027https://doi.org/10.1021/om00038a027research-articleACS PublicationsRequest reuse permissionsArticle Views526Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative Intramolecular Singlet Fission in Bipentacenes (2015)

Singlet fission (SF) has the potential to significantly enhance the photocurrent in single-junction solar cells and thus raise the power conversion efficiency from the Shockley-Queisser limit of 33% to 44%. Until now, quantitative SF yield at room temperature has been observed only in crystalline solids or aggregates of oligoacenes. Here, we employ transient absorption spectroscopy, ultrafast photoluminescence spectroscopy, and triplet photosensitization to demonstrate intramolecular singlet fission (iSF) with triplet yields approaching 200% per absorbed photon in a series of bipentacenes. Crucially, in dilute solution of these systems, SF does not depend on intermolecular interactions. Instead, SF is an intrinsic property of the molecules, with both the fission rate and resulting triplet lifetime determined by the degree of electronic coupling between covalently linked pentacene molecules. We found that the triplet pair lifetime can be as short as 0.5 ns but can be extended up to 270 ns.
Best Response Model Predictive Control for Agile Interactions Between Autonomous Ground Vehicles (2018)

We introduce an algorithm for autonomous control of multiple fast ground vehicles operating in close proximity to each other. The algorithm is based on a combination of the game theoretic notion of iterated best response, and an information theoretic model predictive control algorithm designed for non-linear stochastic systems. We test the algorithm on two one-fifth scale AutoRally platforms traveling at speeds upwards of 8 meters per second, while maintaining a following distance of under two meters from bumper-to-bumper.
A Phase I Study of a Combination of Yttrium-90–Labeled Anti–Carcinoembryonic Antigen (CEA) Antibody and Gemcitabine in Patients with CEA-Producing Advanced Malignancies (2009)

Feasibility of combining gemcitabine with an yttrium-90-labeled anti-CEA antibody is shown with preliminary evidence of clinical response.
Use of cystatin C determination in clinical diagnostics. (2003)

This paper presents a current view of the possible clinical uses of cystatin C determination. Cystatin C is an inhibitor of cysteine proteases, and relatively stable in the systemic circulation it is comparatively easily determined. Although in clinical practice it is known primarily as a relatively reliable and endogenous marker for glomerular filtration, lately cystatin C analysis has been discussed in connection with the diagnostics of a variety of diseases such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases.
Semiclassical theory of noise in semiconductor lasers - Part I (1983)

A Van der Pol analysis of laser noise which includes the field intensity dependence of the refractive index is presented. The consequent amplitude phase coupling affects all laser spectra except the power fluctuations spectrum. An analytic expression for the linewidth broadening enhancement due to index variation is given.
Immunotherapy of malignancy by in vivo gene transfer into tumors. (1993)

The immune system confers protection against a variety of pathogens and contributes to the surveillance and destruction of neoplastic cells. Several cell types participate in the recognition and lysis of tumors, and appropriate immune stimulation provides therapeutic effects in malignancy. Foreign major histocompatibility complex (MHC) proteins also serve as a potent stimulus to the immune system. In this report, a foreign MHC gene was introduced directly into malignant tumors in vivo in an effort to stimulate tumor rejection. In contrast to previous attempts to induce tumor immunity by cell-mediated gene transfer, the recombinant gene was introduced directly into tumors in vivo. Expression of the murine class I H-2Ks gene within the CT26 mouse colon adenocarcinoma (H-2Kd) or the MCA 106 fibrosarcoma (H-2Kb) induced a cytotoxic T-cell response to H-2Ks and, more importantly, to other antigens present on unmodified tumor cells. This immune response attenuated tumor growth and caused complete tumor regression in many cases. Direct gene transfer in vivo can therefore induce cell-mediated immunity against specific gene products, which provides an immunotherapeutic effect for malignancy, and potentially can be applied to the treatment of cancer and infectious diseases in man.
Mechanisms of powdery mildew resistance in the Vitaceae family (2010)

The cultivated grapevine, Vitis vinifera, is a member of the Vitaceae family, which comprises over 700 species in 14 genera. Vitis vinifera is highly susceptible to the powdery mildew pathogen Erysiphe necator. However, other species within the Vitaceae family have been reported to show resistance to this fungal pathogen, but little is known about the mechanistic basis of this resistance. Therefore, the frequency of successful E. necator penetration events, in addition to programmed cell death (PCD) responses, were investigated in a representative genotype from a range of different species within the Vitaceae family. The results revealed that penetration resistance and PCD-associated responses, or combinations of both, are employed by the different Vitaceae genera to limit E. necator infection. In order to further characterize the cellular processes involved in the observed penetration resistance, specific inhibitors of the actin cytoskeleton and secretory/endocytic vesicle trafficking function were employed. These inhibitors were demonstrated to successfully break the penetration resistance in V. vinifera against the nonadapted powdery mildew E. cichoracearum. However, the use of these inhibitors with the adapted powdery mildew E. necator unexpectedly revealed that, although secretory and endocytic vesicle trafficking pathways play a crucial role in nonhost penetration resistance, the adapted powdery mildew species may actually require these pathways to successfully penetrate the plant host.
ChemInform Abstract: Non Solvent Reaction: Ammonium Acetate Catalyzed Highly Convenient Preparation of trans‐Cinnamic Acids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.