gebhart/patrepeval huggingface dataset:
Virtual spacing for flexible traffic control (1994)

Abstract Weighted fair queuing emerges as an elegant and effective solution to the problem of integrating real time services with strict delay constraints and high‐speed data services for which significant delays cannot always be avoided. Virtual spacing is a weighted fair queuing scheduling algorithm intended to be applied in the context of the ATM based BISDN. After discussing how virtual spacing allows flexible traffic control for a variety of service types, we discuss the issue of its implementation in switching nodes. The aim of the paper is to highlight the advantages of weighted fair queuing in enabling a truly integrated services network and to propose a technologically feasible implementation.
Dynamic all-optical tuning of transverse resonant cavity modes in photonic bandgap fibers (2005)

Photonic bandgap fibers for transverse illumination containing half-wavelength microcavities have recently been designed and fabricated. We report on the fabrication and characterization of an all-optical tunable microcavity fiber. The fiber is made by incorporating a photorefractive material inside a Fabry-Perot cavity structure with a quality factor Q >200 operating at 1.5 microm. Under short-wavelength transverse external illumination, a 2 nm reversible shift of the cavity resonant mode is achieved. Dynamic all-optical tuning is reported at frequencies up to 400 Hz. Experimental results are compared with simulations based on the amplitude and kinetics of the transient photodarkening effect measured in situ in thin films.
Tracking laser radar for 3-D shape measurements of large industrial objects based on time-of-flight laser rangefinding and position-sensitive detection techniques (1994)

A tracking laser radar device is proposed for the 3-D measurement of the shapes of large industrial objects. The measuring system includes a servo-controlled measuring head and small reflectors attached to the object. The sensor consists of a tracking sensor, a pulsed time-of-flight rangefinder and angle encoders. The implementation of the tracking sensor and its test results are explained in detail. Tracking is accomplished by illuminating the reflectors of the target object and focusing the reflected light on the surface of a four-quadrant (4Q) position-sensitive detector, the signals of which are used to drive the servo motors of the measuring head. The test results show a tracking sensor resolution of about 0.003 mm (/spl sigma/ value) and bias of about /spl plusmn/0.1 mm when the distance and angle of the target reflector vary in the ranges 2-5 m and /spl plusmn/45/spl deg/, respectively. The pointing accuracy of the tracking system was better than /spl plusmn/0.3 mm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Helicobacter pylori breath tests (2002)

H pylori diagnostic breath tests rely on a simple chemical reaction which is based on the natural behaviour of the bacteria. Naturally occuring gastric urea is made up of 99% carbon isotope 12C and 1% carbon isotope 13C. The breath test uses urea enriched with 13C (that is, 99%).



1 Virtually all duodenal ulcers and 80% of gastric ulcers are associated with Helicobacter pylori infections1 



Patients first drink a sachet …
Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles (2010)

Targeted therapy of cancer using oncolytic viruses has generated much interest over the past few years in the light of the limited efficacy and side effects of standard cancer therapeutics for advanced disease. In 2006, the world witnessed the first government-approved oncolytic virus for the treatment of head and neck cancer. It has been known for many years that viruses have the ability to replicate in and lyse cancer cells. Although encouraging results have been demonstrated in vitro and in animal models, most oncolytic viruses have failed to impress in the clinical setting. The explanation is multifactorial, determined by the complex interactions between the tumor and its microenvironment, the virus, and the host immune response. This review focuses on discussion of the obstacles that oncolytic virotherapy faces and recent advances made to overcome them, with particular reference to adenoviruses.
Gene expression profiling predicts clinical outcome of prostate cancer (2004)

One of the major problems in management of prostate cancer is the lack of reliable genetic markers predicting the clinical course of the disease. We analyzed expression profiles of 12,625 transcripts in prostate tumors from patients with distinct clinical outcomes after therapy as well as metastatic human prostate cancer xenografts in nude mice. We identified small clusters of genes discriminating recurrent versus nonrecurrent disease with 90% and 75% accuracy in two independent cohorts of patients. We examined one group of samples (21 tumors) to discover the recurrence predictor genes and then validated the predictive power of these genes in a different set (79 tumors). Kaplan-Meier analysis demonstrated that recurrence predictor signatures are highly informative (P < 0.0001) in stratification of patients into subgroups with distinct relapse-free survival after therapy. A gene expression–based recurrence predictor algorithm was informative in predicting the outcome in patients with early-stage disease, with either high or low preoperative prostate-specific antigen levels and provided additional value to the outcome prediction based on Gleason sum or multiparameter nomogram. Overall, 88% of patients with recurrence of prostate cancer within 1 year after therapy were correctly classified into the poor-prognosis group. The identified algorithm provides additional predictive value over conventional markers of outcome and appears suitable for stratification of prostate cancer patients at the time of diagnosis into subgroups with distinct survival probability after therapy.
The Ocular Hypertension Treatment Study (2002)

Topical ocular hypotensive medication was effective in delaying or preventing the onset of POAG in individuals with elevated IOP. Although this does not imply that all patients with borderline or elevated IOP should receive medication, clinicians should consider initiating treatment for individuals with ocular hypertension who are at moderate or high risk for developing POAG.
Nanoscaled Reinforcement of Polystyrene Foams using Carbon Nanofibers (2006)

Carbon nanofibers (CNFs) are used as both the nucleants and the reinforcements for polystyrene (PS) foams in both batch and continuous extrusion processes with CO 2 as the blowing agent. The inclusion of CNFs exhibits substantial impact on the morphology and properties of PS foams. The presence of CNFs results in a decrease in the cell size and an increase in the cell density. Macroscopic strength enhancement of PS foams due to the incorporation of CNFs is experimentally observed. These results are qualitatively explained via a series of nanoscaled observations. Through scanning electron microscopy (SEM), the alignment of CNFs and the polymer-sheathing phenomenon are identified. The protective CNF layers around the cell wall and the substantial polymer-fiber interactions resulted in the enhancement of foam strengths. Thermal properties (heat conductivity, infrared transmission, and thermal expansion coefficient) of the PS foams can also be influenced by CNFs. Intensive shear force exerted by the twin-screw extruder broke the fibers in lengths. The impact of the fiber length on the foam structures (cell size and cell density) is also studied.
Multiple thiol-anchor capped DNA-gold nanoparticle conjugates (2002)

We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.
Synergistic Effects of ANP and Sildenafil on cGMP Levels and Amelioration of Acute Hypoxic Pulmonary Hypertension (2004)

We hypothesized that the phosphodiesterase 5 inhibitor, sildenafil, and the guanosine cyclase stimulator, atrial natriuretic peptide (ANP), would act synergistically to increase cGMP levels and blunt hypoxic pulmonary hypertension in rats, because these compounds act via different mechanisms to increase the intracellular second messenger. Acute hypoxia: Adult Sprague-Dawley rats were gavaged with sildenafil (1 mg/ kg) or vehicle and exposed to acute hypoxia with and without ANP (10(-8)-10(-5) M ). Sildenafil decreased systemic blood pressure (103 +/- 10 vs. 87 +/- 6 mm Hg, P < 0.001) and blunted the hypoxia-induced increase in right ventricular systolic pressure (RVSP; percent increase 73.7% +/- 9.4% in sildenafil-treated rats vs. 117.2% +/- 21.1% in vehicle-treated rats, P = 0.03). Also, ANP and sildenafil had synergistic effects on blunting the hypoxia-induced increase in RVSP (P < 0.001) and on rising plasma cGMP levels (P < 0.05). Chronic hypoxia: Other rats were exposed to prolonged hypoxia (3 weeks, 0.5 atm) after subcutaneous implantation of a sustained-release pellet containing lower (2.5 mg), or higher (25 mg) doses of sildenafil, or placebo. Higher-dose, but not lower-dose sildenafil blunted the chronic hypoxia-induced increase in RVSP (P = 0.006). RVSP and plasma sildenafil levels were inversely correlated in hypoxic rats (r(2) = 0.68, P = 0.044). Lung cGMP levels were increased by both chronic hypoxia and sildenafil, with the greatest increase achieved by the combination. Plasma and right ventricular (RV) cGMP levels were increased by hypoxia, but sildenafil had no effect. RV hypertrophy and pulmonary artery muscularization were also unaffected by sildenafil. In conclusion, sildenafil and ANP have synergistic effects on the blunting of hypoxia-induced pulmonary vasoconstriction. During chronic hypoxia, sildenafil normalizes RVSP, but in the doses used, sildenafil has no effect on RV hypertrophy or pulmonary vascular remodeling.
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice (2008)

Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of beta-amyloid (Abeta) before formation of senile plaques. However, persistent Abeta accumulation despite increasing microglial numbers suggests that the ability of microglia to clear Abeta may decrease with age and progression of AD pathology. To determine the effects of aging and Abeta deposition on microglial ability to clear Abeta, we used quantitative PCR to analyze gene expression in freshly isolated adult microglia from 1.5-, 3-, 8-, and 14-month-old transgenic PS1-APP mice, an established mouse model of AD, and from their nontransgenic littermates. We found that microglia from old PS1-APP mice, but not from younger mice, have a twofold to fivefold decrease in expression of the Abeta-binding scavenger receptors scavenger receptor A (SRA), CD36, and RAGE (receptor for advanced-glycosylation endproducts), and the Abeta-degrading enzymes insulysin, neprilysin, and MMP9, compared with their littermate controls. In contrast, PS1-APP microglia had a 2.5-fold increase in the proinflammatory cytokines IL-1beta (interleukin-1beta) and tumor necrosis factor alpha (TNFalpha), suggesting that there is an inverse correlation between cytokine production and Abeta clearance. In support of this possibility, we found that incubation of cultured N9 mouse microglia with TNFalpha decreased the expression of SRA and CD36 and reduced Abeta uptake. Our data indicate that, although early microglial recruitment promotes Abeta clearance and is neuroprotective in AD, as disease progresses, proinflammatory cytokines produced in response to Abeta deposition downregulate genes involved in Abeta clearance and promote Abeta accumulation, therefore contributing to neurodegeneration. Antiinflammatory therapy for AD should take this dichotomous microglial role into consideration.
Effect of Lactacidosis on Pyridine Nucleotide Stability During Ischemia in Mouse Brain (1987)

Brain levels of NADH and NAD+ were measured in three models of cerebral ischemia to determine whether degradation of the pyridine nucleotides is enhanced in models that generate high concentrations of lactic acid. Complete ischemia (decapitation), in which lactate increased to 14 mmol/kg, caused a gradual decrease in the NAD pool to 50% of control by 2 h. During focal ischemia (occlusion of the middle cerebral artery), the decrease in the NAD pool was less pronounced (82% of control at 2 h) despite the accentuated accumulation of lactate to 33 mmol/kg. In a third model (unilateral hypoxia-ischemia), pretreatment of animals with glucose augmented the ischemic elevation of lactate from 30 mmol/kg to 40 mmol/kg and greatly impaired restoration of energy metabolites during recirculation. However, glucose pretreatment had no effect on the size of the NAD pool during ischemia or early recovery. These results, therefore, demonstrate that the pyridine nucleotide pool is not rapidly degraded during ischemic insults that accumulate high concentrations of lactic acid. The stability of the NAD pool may have been enhanced by the limited increase in brain levels of NADH that occurred in these models of incomplete ischemia.
The monoclonal antibody TER‐119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage (2000)

The antigen specificity of a rat monoclonal antibody TER-119 was investigated. In adult mice, TER-119 reacted with mature erythrocytes, 20-25% of bone marrow cells and 2-3% of spleen cells but not with thymocytes nor lymph node cells. In fetal haematopoietic tissues, 30-40% of d 10 yolk sac cells, 80-90% of d 14 fetal liver cells and 40-50% of newborn liver cells were reactive with TER-119. TER-119+ cells in adult bone marrow expressed significant levels of CD45 but not myeloid (Mac-1, Gr-1) or B-cell (B220) markers. Morphological examination and haematopoietic colony-forming assays for isolated TER-119+ cells revealed that TER-119 reacts with erythroid cells at differentiation stages from early proerythroblast to mature erythrocyte, but not with cells showing typical erythroid blast-forming unit (BFU-E) and erythroid colony-forming unit (CFU-E) activities. Erythroleukaemia cell lines do not express the TER-119 antigen even after stimulation with dimethylsulphoxide. TER-119 immunoprecipitated protein bands with molecular masses of 110 kDa, 60 kDa, 52 kDa and 32 kDa from erythrocyte membrane, whereas only a 52-kDa band was detected by TER-119 in Western blot analysis. Further molecular and cellular analyses indicated that the TER-119 antigen is a molecule associated with cell-surface glycophorin A but not with glycophorin A itself.
Quantitation of peptide anchor residue contributions to class I major histocompatibility complex molecule binding. (1993)

Class I major histocompatibility complex molecules play an important role in cellular immunity by presenting antigenic peptides to cytotoxic T cells. Deep polymorphic pockets in the peptide-binding groove of class I major histocompatibility complex molecules provide structural complementarity for peptide "anchor" side chains. However, the minimum requirements of a peptide for high-affinity binding and the contribution of anchor side chains to binding have not been determined yet. To address these issues, we have compared the affinities of various octapeptides for purified, soluble H-2Kb molecules. The results revealed that at least 2 anchor residues are necessary for high-affinity binding, and that high-affinity binding occurs only when anchor side chains are optimally packed within the groove. The estimated free energy contribution of two anchor side chains to binding is unexpectedly large and comparable with that of peptide backbone, suggesting a crucial role of anchor residues in high-affinity, and hence specific, binding to class I molecules.
Elastase in Tissue Injury (1985)

This article surveys elastinolytic proteinases in man, excluding enzymes of the pancreas and digestive tract. Special emphasis is placed on the elastase of polymorphonuclear neutrophils (PMN). The properties of this latter enzyme, its target molecules in plasma and connective tissues, and its endogenous regulators are briefly discussed. Persistent activity of the enzyme, even in the presence of its regulatory inhibitors, is explained. The chapter closes with a brief discussion of several pulmonary diseases in which elastase-mediated tissue injury is thought to play a role.
A proposed collector design of double heterojunction bipolar transistors for power applications (1995)

A new collector design for the AlGaAs-GaAs double heterostructure bipolar transistor (DHBT) is proposed, analyzed, and simulated. The base-collector junction is linearly graded and terminated with a highly doped thin layer to offset the adverse alloy grading electric field. Simple analytical formulas are derived to facilitate the implementation of the design. A proof-of-principle simulation has been carried out for an X-band AlGaAs-GaAs power DHBT to confirm the design and the derived formula. The simulation shows the breakdown voltage can be increased from 30 V to about 45 V while the critical current density is about the same. It is also shown that, unlike other refined DHBT structures, the proposed structure does not require critical control in the fabrication of the base-collector junction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Successful ablation of a left-sided accessory pathway in a patient with coronary sinus atresia and arteriovenous fistula: clinical and developmental insights. (2011)

Cardiac conduction development is complex and accessory pathway conduction may occur in the setting of arteriovenous anomalies thus providing insights as to the cause of WPW syndrome. Successful mapping and targeted ablation of left-sided pathways may be accomplished even when coronary sinus access is not possible.
Multicast Extensions to OSPF (1994)

This memo documents enhancements to the OSPF protocol enabling the routing of IP multicast datagrams. In this proposal, an IP multicast packet is routed based both on the packet's source and its multicast destination (commonly referred to as source/destination routing). As it is routed, the multicast packet follows a shortest path to each multicast destination. During packet forwarding, any commonality of paths is exploited; when multiple hosts belong to a single multicast group, a multicast packet will be replicated only when the paths to the separate hosts diverge.
One-End Immobilization of Individual DNA Molecules on a Functional Hydrophobic Glass Surface (2002)

We demonstrate an effective method for DNA immobilization on a hydrophobic glass surface. The new DNA immobilizing technique is extremely simple compared with conventional techniques that require heterobifunctional crosslinking reagent between DNA and substrate surface that are both modified chemically. In the first process, a coverslip was treated with dichlorodimethylsilane resulting in hydrophobic surface. lambda DNA molecules were ligated with 3'-terminus disulfide-modified 14 mer oligonucleotides at one cohesive end. After reduction of the disulfide to sulfhydryl (thiol) groups the resulting thiol-modified lambda DNA molecules were reacted on silanized coverslip. Fluorescent observation showed that the thiol-modified lambda DNA molecules were anchored specifically to the hydrophobic surface at one terminus, although non-specific binding of the DNA molecules was suppressed. It was observed that the one-end-attached DNA molecule was bound firmly to the surface and stretched reversibly in one direction when a d.c. electric field was applied.
Optical resolution of bicyclo[2.2.1]heptanone, bicyclo[2.2.2]octanone, and bicyclo[3.2.1]octanone derivatives by inclusion complexation with optically active host compounds (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical resolution of bicyclo[2.2.1]heptanone, bicyclo[2.2.2]octanone, and bicyclo[3.2.1]octanone derivatives by inclusion complexation with optically active host compoundsFumio Toda, Koichi Tanaka, David Marks, and Israel GoldbergCite this: J. Org. Chem. 1991, 56, 26, 7332–7335Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/jo00026a027https://doi.org/10.1021/jo00026a027research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparison of Enzymatic (E‐Mill) and Conventional Dry‐Grind Corn Processes Using a Granular Starch Hydrolyzing Enzyme (2005)

ABSTRACT A new low temperature liquefaction and saccharification enzyme STARGEN 001 (Genencor International, Palo Alto, CA) with high granular starch hydrolyzing activity was used in enzymatic dry‐grind corn process to improve recovery of germ and pericarp fiber before fermentation. Enzymatic dry‐grind corn process was compared with conventional dry‐grind corn process using STARGEN 001 with same process parameters of dry solid content, pH, temperature, enzyme and yeast usage, and time. Sugar, ethanol, glycerol and organic acid profiles, fermentation rate, ethanol and coproducts yields were investigated. Final ethanol concentration of enzymatic dry‐grind corn process was 15.5 ± 0.2% (v/v), which was 9.2% higher than conventional process. Fermentation rate was also higher for enzymatic dry‐grind corn process. Ethanol yields of enzymatic and conventional dry‐grind corn processes were 0.395 ± 0.006 and 0.417 ± 0.002 L/kg (2.65 ± 0.04 and 2.80 ± 0.01 gal/bu), respectively. Three additional coproducts, germ 8.0 ± 0.4% (db), pericarp fiber 7.7 ± 0.4% (db), and endosperm fiber 5.2 ± 0.6% (db) were produced in addition to DDGS with enzymatic dry‐grind corn process. DDGS generated from enzymatic dry‐grind corn process was 66% less than conventional process.