gebhart/patrepeval huggingface dataset:
Mechanism of Enhanced Susceptibility to Sepsis Following Hemorrhage (1994)

Decreased splenocyte/T-cell proliferation was associated with enhanced release of IL-10 by cells from hemorrhaged mice. However, unlike T cells, IL-10 release by macrophages was not comparatively elevated. While no changes were seen in systemic plasma levels of IL-10, the role of IL-10 as a localized immunosuppressant was demonstrated by the ability of IL-10 monoclonal antibody to restore T-cell proliferation following hemorrhage. Furthermore, elevated IL-10 release was prevented by the addition of ibuprofen or monoclonal antibody against transforming growth factor beta or IL-6. Since these agents have direct or indirect influences on prostanoid synthesis, studies were carried out examining the capacity of varying concentrations of prostaglandin E2 (PGE2) to augment IL-10 release by murine cloned Th2 cells (D10.G4.1) and by T cells from sham-operated or hemorrhaged mice. While the addition of PGE2, 10(-9) mol/L, potentiated the release of IL-10, this effect appears to be indirect, since the incorporation of monoclonal antibody to IL-4 prevented the release of IL-10 by PGE2-treated cells from sham-operated or hemorrhaged mice. Such a mechanism of eicosanoid-induced IL-4/IL-10 cell-mediated immunosuppression may directly contribute to the decreased capacity to ward off infectious challenge seen following hemorrhage.
Clinical Trials of HIV Vaccines (2002)

Development of a preventive vaccine for HIV is the best hope of controlling the AIDS pandemic. Evidence from natural history studies and experiments in animal models indicates that immunity against HIV is possible, suggesting that vaccine development is feasible. These studies have shown that sufficient levels of neutralizing antibody against HIV can prevent infection, although the effect is type-specific. In contrast, HIV-specific cytotoxic T lymphocyte (CTL) activity has broad cross-reactivity, and although CTL activity alone cannot prevent HIV infection, it can control the level of viremia at a low level. Evaluation of candidate vaccines in human trials has focused on approaches that can safely elicit HIV-specific antibody and T cell responses. Current strategies have been unable to induce antibody with broad neutralizing activity against primary HIV isolates. However, recombinant poxvirus and DNA vaccines have elicited CTL responses that are broadly cross-reactive against primary HIV isolates from diverse clades. Future advances will require the discovery of new immunogens that can induce neutralizing antibody, as well as efficacy trial evaluation of regimens optimized for CTL induction.
Microwave thermal imaging of scanned focused ultrasound heating: Phantom results (2008)

We are developing a microwave tomographic imaging system capable of monitoring thermal distributions based on the temperature dependence of the recovered dielectric properties. The system has been coupled to a high intensity focused ultrasound (HIFU) therapy device which can be mechanically steered under computer control to generate arbitrarily shaped heating zones. Their integration takes advantage of the focusing capability of ultrasound for the therapy delivery and the isolation of the microwave imaging signal from the power deposition source to allow simultaneous treatment monitoring. We present several sets of phantom experiments involving different types of heating patterns that demonstrate the quality of both the spatial and temporal thermal imaging performance. This combined approach is adaptable to multiple anatomical sites and may have the potential to be developed into a viable alternative to current clinical temperature monitoring devices for HIFU, such magnetic resonance (MR) imaging.
Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV (2010)

The discovery of two classes of heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is described. After a single oral dose, these potent, selective, and noncovalent inhibitors provide sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes. Compounds 13a, 27b, and 27j were selected for development.
Umsetzungen mit N‐Carbonyl‐sulfamidsäure‐chlorid, I. Über das Sulfamidsäurechlorid (1959)

Abstract Durch partielle Hydrolyse läßt sich N ‐Carbonyl‐sulfamidsäure‐chlorid in Sulfamidsäurechlorid überführen. Es werden Vorschriften zur laboratoriumsmäßigen Herstellung dieser Verbindung mitgeteilt und einige Umsetzungen damit beschrieben.
Regulatory T cells and IL-10 in allergic inflammation (2005)

Recent studies suggest that human regulatory T (T reg) cells protect against the development of allergic and asthmatic disease and that their function is impaired during active disease. Two new studies contribute to our understanding of the role that T reg cells play in the control of allergic airway disease in mice. However, these studies also highlight several outstanding questions in the field.
Software-Defined Network Virtualization Platform for Enterprise Network Resource Management (2015)

Applications of a software-defined network (SDN) have increased. Notably an SDN has the benefits of programmability and automation for network control. It also realizes network virtualization. Based on the OpenFlow/FlowVisor network virtualization layer, this paper proposes a dynamic resource management scheme, called the EnterpriseVisor engine that manages the distribution of network resources among slices. The EnterpriseVisor engine first slices an enterprise's network into virtual subnets, and then continues to monitor the resource utilization of each subnet. In the engine, dynamic resource scheduling of the subnet for each service uses the linear programming method. The engine then delivers the schedule as the resource allocation policy of the FlowVisor layer for data plane users. To demonstrate the feasibility of the proposed EnterpriseVisor engine, an OpenFlow testbed with four subnets is designed. Compared with the basic OpenFlow and OpenFlow/FlowVisor platforms, the EnterpriseVisor engine has higher network utilization, 25.7% and 13.4% higher, respectively, with only a minor sacrifice to control message latency.
Comment (2003)

Research Article| May 01, 2003 Comment Ellen Thomas Ellen Thomas 1Department of Earth and Environmental Sciences, Wesleyan University, Middletown, Connecticut 06459-0139, USA Search for other works by this author on: GSW Google Scholar Author and Article Information Ellen Thomas 1Department of Earth and Environmental Sciences, Wesleyan University, Middletown, Connecticut 06459-0139, USA Publisher: Geological Society of America First Online: 02 Jun 2017 Online ISSN: 1943-2682 Print ISSN: 0091-7613 Geological Society of America Geology (2003) 31 (5): 470. https://doi.org/10.1130/0091-7613(2003)031<0470:PTSMEF>2.0.CO;2 Article history First Online: 02 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Ellen Thomas; Comment. Geology 2003;; 31 (5): 470. doi: https://doi.org/10.1130/0091-7613(2003)031<0470:PTSMEF>2.0.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGeology Search Advanced Search The stratigraphy of upper Paleocene and lower Eocene sediments in the North Sea region is highly complex, biostratigraphical correlations are difficult, and the fact that the Epoch boundaries were defined in this region has caused many problems. Jolley et al. (2002) argue that recent estimates of the numerical age of events occurring close to the Paleocene-Eocene boundary are incorrect, because sediments “between and equivalent to the oldest lavas contain an influx of a diagnostic pollen flora, an influx of the dinocyst Apectodinium, a benthic foraminiferal extinction, nannofossil zone NP9, and a carbon isotope excursion associated with the late Paleocene... You do not have access to this content, please speak to your institutional administrator if you feel you should have access.
On Block Elimination for Sparse Linear Systems (1974)

We consider the solution of linear equations involving a sparse coefficient matrix having a triangular factorization. In addition to the usual triangular factorization, we consider block factorizations, where the diagonal blocks of the factors are not necessarily triangular. We show that under certain sparsity conditions, these alternate factorizations may require fewer arithmetic operations and less storage. In particular, we obtain the surprising result that it may be beneficial to compute an unsymmetric factorization of a symmetric matrix.
Monoclonal antibody therapy of cancer. (1999)

Monoclonal antibody therapy is beginning to realize its promise. Efficacy has been seen in clinical trials using antibodies that target tumor cell surface antigens such as B-cell idiotypes, CD20 on malignant B cells, CD33 on leukemic blasts, and HER2/neu on breast cancer. Unconjugated immunoglobulins directed against CD20 induce partial and complete responses in up to 50% of patients with advanced, indolent non-Hodgkin's lymphoma. When such antibodies are conjugated to radionuclides, complete and overall response rates increase. Conjugates composed of anti-CD33 antibodies and the chemotherapy agent, calicheamicin, show promising activity in patients with relapsed or refractory acute myelogenous leukemia Treatment of patients with advanced breast cancer using the anti-HER2/neu antibody, trastuzumab (Herceptin; Genentech, San Francisco, CA) leads to objective responses in some patients with overexpression of the HER2/neu oncoprotein. These exciting results provide a basis for further refinement of the existing approaches to develop new antibody-based cancer therapy strategies.
The “Sound” Team: A Speech-Language Pathologist/Educator Collaboration in Early Literacy Development (2003)

No AccessPerspectives on School-Based IssuesArticle1 Apr 2003The “Sound” Team: A Speech-Language Pathologist/Educator Collaboration in Early Literacy Development Heather L. Sample Heather L. Sample Department of Elementary Education, University of AlbertaEdmonton, Alberta, Canada Google Scholar More articles by this author https://doi.org/10.1044/sbi4.1.22 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Bear, D. R., Invernizzi, M., Templeton, S., & Johnston, F. (1996). Words their way: Word study for phonics, vocabulary, and spelling. Upper Saddle River, NJ: Prentice-Hall. Google Scholar Catts, H. W., & Kamhi, A. G. (1999). Language and reading disabilities. Needham Heights, MA: Allyn and Bacon. Google Scholar Catts, H., & Vartiainen, T. (1993). Sounds abound: Listening, rhyming, and reading. East Moline, IL: LinguiSystems. Google Scholar Idol, L., Paolucci-Whitcomb, P., & Nevin, A. (1986). Collaborative consultation. Austin, TX: PRO-ED. Google Scholar Lenchner, O., & Podhajski, B. (1998). The sounds abound program. East Moline, IL: LinguiSystems Google Scholar Lindamood, P. C., & Lindamood, P. D. (1998). The Lindamood phoneme sequencing program for reading, spelling, and speech. Austin, TX: PRO-ED. Google Scholar Robertson, C., & Salter, W. (1995). The phonological awareness kit. East Moline, IL: LinguiSystems Google Scholar Wellington County Board of Education. (1995). The phonological awareness companion: Making the speech-print connection. East Moline, IL: Lingui Systems. Google Scholar Additional Resources FiguresReferencesRelatedDetails Volume 4Issue 1April 2003Pages: 22-26 Get Permissions Add to your Mendeley library History Published in issue: Apr 1, 2003 Metrics Downloaded 54 times Topicsasha-topicsleader-topicsasha-article-typesasha-sigsCopyright & PermissionsCopyright © 2003 American Speech-Language-Hearing AssociationLoading ...
Expression of cystathionine β-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis (2009)

The cystathionine beta-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis of cystathionine in the trans-sulfuration pathway and is subject to tight regulation because of its critical role in antioxidant and methylation metabolism. The expression level of CBS in 120 hepatocellular carcinoma (HCC) specimens evaluated by real-time reverse transcriptase PCR (RT-PCR) is markedly lower than in surrounding non-cancerous liver (P<0.0001). The correlation between CBS gene expression in HCC and clinicopathological parameters or survival of HCC patients was statistically analyzed in the present study. Our study demonstrated that reduced CBS expression is significantly correlated with high tumor stage (P=0.0019), high Edmondson grade (P=0.00084), and high AFP level (P=6.2x10(-5)). Interestingly, a survival analysis showed that a significantly shorter overall survival (OS) time is observed in patients with reduced CBS expression (P=0.0022), although CBS expression was determined not to be an independent prognostic factor for OS (P=0.071) after considering tumor stage, tumor size, and AFP level. However, for the 62 patients with low AFP levels (<100 ng/ml), reduced CBS expression was found to be an independent prognostic factor for OS (P=0.0042) after considering tumor stage and tumor size. Thus, the expression level of CBS mRNA could be useful to predict clinical outcome of HCC, especially for patients with low AFP levels.
Dipeptidyl peptidase-4 inhibition improves left ventricular function in chronic kidney disease (2014)

The beneficial cardiac effects of DPP-4 inhibition, in the absence of a concurrent improvement in renal dysfunction, raise the possibility that these agents may confer cardiovascular advantages in the CKD population.
Coating the surface: a model for expression of capsular polysialic acid in Escherichia coli K1 (1996)

Capsules are well-studied components of the bacterial surface that modulate interactions between the cell and its environment. Generally composed of polysaccharide, they are key virulence determinants in invasive infections in humans and other animals. Genetic determinants involved in capsule expression have been isolated from a number of organisms, but perhaps the best characterized is the kps cluster of Escherichia coli K1. In this review, the current understanding of the functions of the kps gene products is summarized. Further, a proposed mechanistic model for capsule expression is presented and discussed. The model is based on the premise that the numerous components of the kps cluster form a hetero-oligomeric complex responsible for synthesis and concurrent translocation of the capsular polysialic acid through sites of inner and outer membrane fusion. We view the ATP-binding cassette (ABC) transporter, KpsMT, to be central to the functioning of the complex, interacting with the biosynthetic apparatus as well as the extracytoplasmic components of the cluster to co-ordinate synthesis and translocation. The model provides the basis for additional experimentation and reflects emerging similarities among systems responsible for macromolecular export in Gram-negative bacteria.
The Sabra rat: definition of a laboratory animal. (1984)

Study objectives were to provide investigators of the biomedical research community with comprehensive and reliable baseline data for the Sabra rat strain. In addition to a physiological, developmental, hematological and biochemical definition of this laboratory rat, widely used at the Hebrew University and other research laboratories in Israel, a historical insight offers some understanding of the origin and development of this strain. Data collected from 331 male and female rats over a 2-year period characterize the Sabra rat as a useful, stable, economical laboratory animal with good viability under conventional conditions.
A sparse approximate inverse to the IML matrices allows solution in 5 iterations (1992)

A sparse approximate inverse to the impedance matrix localization (IML) method is described which allows solution in five iterations. Numerical results show how well the method discussed works.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A modify technique to actively damp oscillation in the input LC filter of Three-phase PWM rectifier (2008)

This paper proposes a modify technique to actively damp oscillation in the input LC filter of a three-phase PWM rectifier. The oscillation in the LC input filter of a three-phase PWM rectifier is damped by controlling voltage across the filter inductor. The principle is based on controlling the switches such that the input current of the filter follows the reference sine wave which is in-phase with the voltage to improve the power factor. The simulation results show that the proposed method can reduce current and voltage harmonic distortion at the point of common coupling and improve the power factor.
Selective-Polysilicon Emitter, Self-Aligned Bipolar Structure for BiCMOS VLSI Applications (1991)

A new self-aligned bipolar structure, which features selectively deposited polysilicon emitter and non-recessed base, is proposed. High quality selective-polysilicon film, excellent submicron bipolar device characteristics, and improved bipolar hot-carrier immunity have been demonstrated. This bipolar process module is also readily interactable into a CMOS--base BiCMOS flow for deep submicron VLSI applications.
The old problems of glass and the glass transition, and the many new twists. (1995)

In this paper I review the ways in which the glassy state is obtained both in nature and in materials science and highlight a "new twist"--the recent recognition of polymorphism within the glassy state. The formation of glass by continuous cooling (viscous slowdown) is then examined, the strong/fragile liquids classification is reviewed, and a new twist-the possibility that the slowdown is a result of an avoided critical point-is noted. The three canonical characteristics of relaxing liquids are correlated through the fragility. As a further new twist, the conversion of strong liquids to fragile liquids by pressure-induced coordination number increases is demonstrated. It is then shown that, for comparable systems, it is possible to have the same conversion accomplished via a first-order transition within the liquid state during quenching. This occurs in the systems in which "polyamorphism" (polymorphism in the glassy state) is observed, and the whole phenomenology is accounted for by Poole's bond-modified van der Waals model. The sudden loss of some liquid degrees of freedom through such weak first-order transitions is then related to the polyamorphic transition between native and denatured hydrated proteins, since the latter are also glass-forming systems--water-plasticized, hydrogen bond-cross-linked chain polymers (and single molecule glass formers). The circle is closed with a final new twist by noting that a short time scale phenomenon much studied by protein physicists-namely, the onset of a sharp change in d<r2>/dT (<r2> is the Debye-Waller factor)--is general for glass-forming liquids, including computer-simulated strong and fragile ionic liquids, and is closely correlated with the experimental glass transition temperature. The latter thus originates in strong anharmonicity in certain components of the vibrational density of states, which permits the system to access the multiple minima of its configuration space. The connection between the anharmonicity in these modes, vibrational localization, the Kauzmann temperature, and the fragility of the liquid is proposed as the key problem in glass science.
Pathophysiology of adult polycystic kidney disease. (1989)

Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder characterized by cyst formation or structural defects in the vascular tree, cardiac valves, gastrointestinal tract, and kidneys. The pathophysiologic basis for these manifold abnormalities is consistent with a pervasive defect in the extracellular matrix. Moreover, this theory fits well with the hypothesis that autosomal dominant disorders frequently represent structural defects. The goal of this discussion is to relate the clinical manifestations of this disorder to its genetic origins and to the proposed extracellular matrix defect.
Cell‐Based Therapies for Diabetes: Progress towards a Transplantable Human β Cell Line (2003)

Achieving normoglycemia is the goal of diabetes therapy. Potentially, there are many ways to achieve this goal, including transplantation of cells exhibiting glucose-responsive insulin secretion. However, to be applicable to the large number of people who might benefit from beta cell replacement, an unlimited supply of beta cells must be found. To address this problem, we have been developing cell lines from the human endocrine pancreas. In one case, a cell line, betalox5, has been developed from human islets that can be induced under some circumstances to differentiate into functional beta cells exhibiting appropriate glucose-responsive insulin secretion. Inducing differentiation is complex, requiring the activation of multiple signaling pathways, including those downstream of those involved in cell-cell contact and the glucagon-like peptide-1 receptor. In addition, transfer of the PDX-1 gene is also necessary to render the cells competent for differentiation. However, it is clear that many other genes are involved in maintaining the commitment of betalox5 cells towards the beta cell lineage. Understanding the complement of genes required to establish and maintain a beta cell lineage commitment would be enormously helpful in efforts to develop a cell line that can be used for beta cell replacement therapies. Here, we provide further information on the characteristics of cell lines that we have developed from the human pancreas that are relevant to the development of a beta cell replacement therapy for diabetes.
Drug-Induced Acute Liver Failure (2010)

DILI is an uncommon cause of ALF that evolves slowly, affects a disproportionate number of women and minorities, and shows infrequent spontaneous recovery, but transplantation affords excellent survival.
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube (1996)

We speculate that the high constitutive levels of leukemia inhibitory factor expressed in the ampullary portion of the fallopian tube may play a role in early embryonic development. Additionally, elevated expression with ectopic implantation and the marked induction of secretion in the tubal stroma by growth factors and cytokines suggest a link between inflammation, leukemia inhibitory factor, and tubal ectopic pregnancies.
(+)-Larreatricin hydroxylase, an enantio-specific polyphenol oxidase from the creosote bush ( Larrea tridentata ) (2003)

An enantio-specific polyphenol oxidase (PPO) was purified approximately 1,700-fold to apparent homogeneity from the creosote bush (Larrea tridentata), and its encoding gene was cloned. The posttranslationally processed PPO ( approximately 43 kDa) has a central role in the biosynthesis of the creosote bush 8-8' linked lignans, whose representatives, such as nordihydroguaiaretic acid and its congeners, have potent antiviral, anticancer, and antioxidant properties. The PPO primarily engenders the enantio-specific conversion of (+)-larreatricin into (+)-3'-hydroxylarreatricin, with the regiochemistry of catalysis being unambiguously established by different NMR spectroscopic analyses; the corresponding (-)-enantiomer did not serve as a substrate. This enantio-specificity for a PPO, a representative of a widespread class of enzymes, provides additional insight into their actual physiological roles that hitherto have been difficult to determine.