gebhart/patrepeval huggingface dataset:
Comparison of hybrid FDMA/CDMA systems in frequency selective Rayleigh fading (1994)

A hybrid FDMA/CDMA scheme operating over a frequency selective Rayleigh fading channel is described and analyzed. The performance of the hybrid system is then compared with that of a wideband CDMA system occupying the same total bandwidth. Both coherent and noncoherent modulation formats are investigated; it is found that, for coherent modulation with a RAKE receiver, wideband CDMA has greater capacity than does the hybrid. However, for the noncoherent modulation formats (either DPSK or square-law detected orthogonal signalling), a hybrid system can have a greater capacity if a high channel error rate can be tolerated. Otherwise, a wideband noncoherent system remains optimal.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Spontaneous emission in microcavities with distributed mirrors (1995)

This paper presents an analytic approach to spontaneous emission in resonators with distributed Bragg reflectors (DBR's). The foundation of our analysis is the hard mirror (or penetration depth) approximation. Which we extend to radiation with both angular and frequency distributions. This has allowed us to derive approximate analytic expressions for the divergence angle of the spontaneous emission, the spontaneous emission rate and the spontaneous emission coupling factor in planar DBR resonators. These analytic tools provide insight into the considerable limitations to controlling spontaneous emission with DBR boundaries. We also explore cavity controlled spontaneous emission with the classical tools of intracavity field profiles, the induced EMF method and millimeter wave experiments-all of which are applied to distributed mirror boundaries.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Work Motivation (2015)

Motivation in the workplace is an important determinant of performance, and organizations invest a considerable amount of resources to effectively motivate their employees. As part of this effort, employees are often assigned difficult specific performance goals to enhance their motivation. While goals of this nature are generally effective in maximizing employee motivation, they are not universally optimal. By examining the underlying foundations of motivation using an established self‐regulatory perspective, important individual and situational factors that moderate the effectiveness of performance goals are presented. In addition to discussing important situational moderators (including the nature of the task itself and the rate at which goal progress is being made), a particular emphasis is placed on highlighting aspects of the aging process that may influence how employees respond differently to performance goals as they age.
Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites (1998)

Sequence elements that can function as internal ribosome entry sites (IRES) have been identified in 5' noncoding regions of certain uncapped viral and capped cellular mRNA molecules. However, it has remained largely unknown whether IRES elements are functional when located in their natural capped mRNAs. Therefore, the polysomal association and translation of several IRES-containing cellular mRNAs was tested under conditions that severely inhibited cap-dependent translation, that is, after infection with poliovirus. It was found that several known IRES-containing mRNAs, such as BiP and c-myc, were both associated with the translation apparatus and translated in infected cells when cap-dependent translation of most host-cell mRNAs was blocked, indicating that the IRES elements were functional in their natural mRNAs. Curiously, the mRNAs that encode eukaryotic initiation factor 4GI (eIF4GI) and 4GII (eIF4GII), two proteins with high identity and similar functions in the initiation of cap-dependent translation, were both associated with polysomes in infected cells. The 5'-end sequences of eIF4GI mRNA were isolated from a cDNA expression library and shown to function as an internal ribosome entry site when placed into a dicistronic mRNA. These findings suggest that eIF4G proteins can be synthesized at times when 5' cap-dependent mRNA translation is blocked, supporting the notion that eIF4G proteins are needed in both 5' cap-independent and 5' cap-dependent translational initiation mechanisms.
The approximated cardiovascular reserve index complies with haemorrhage related hemodynamic deterioration pattern: A swine exsanguination model (2016)

Level III.
Reactivity of vibrationally excited methane on nickel surfaces (2001)

Four-dimensional variational calculations have been performed for modeling energy flow between methane (CH4) stretching vibrational energy states as the molecule adiabatically approaches a metallic surface. The model is based on a local mode Hamiltonian for an isolated CH4 molecule and a London-Eyring-Polanyi-Sato potential describing surface–molecule interactions. The results suggest the possibility of mode specific effects on chemical reactivity. Specifically, the symmetric A1 stretch fundamental adiabatically correlates with the localized excitation in the unique CH bond pointing towards the surface. Conversely, the antisymmetric F2 stretch fundamental excitation correlates with A and E vibrations in the CH3 radical, and therefore this degree of freedom is localized away from the reactive CH bond. Landau–Zener semiclassical analysis of nonadiabatic curve crossings predicts a significant velocity dependence to the state specific energy flow dynamics. Since excitation localized in active versus spectator bonds is expected to be more efficient in accelerating CH bond cleavage and adsorption reactivity, these results offer insight into interpreting velocity and vibrationally mediated reaction dynamics of CH4 on catalytic surfaces.
ChemInform Abstract: Enzyme‐Linked Colorimetric Screening of a One‐Bead—One‐Compound Combinatorial Library (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermoelectric Materials: New Approaches to an Old Problem (1997)

Thermoelectrics is an old field. In 1823, Thomas Seebeck discovered that a voltage drop appears across a sample that has a temperature gradient. This phenomenon provided the basis for thermocouples used for measuring temperature and for thermoelectric power generators. In 1838, Heinrich Lenz placed a drop of water on the junction of metal wires made of bismuth and antimony. Passing an electric current through the junction in one direction caused the water to freeze, and reversing the current caused the ice to quickly melt; thus thermoelectric refrigeration was demonstrated (figure 1).
Clinical characteristics, molecular profile and outcomes of myeloid sarcoma: a single institution experience over 13 years (2017)

Failure to achieve CR with induction therapy, and age >65 years are associated with poor outcomes in MS. Allogeneic stem-cell transplant in first remission appears to be the most effective modality for achieving long-term remissions.
Organ-specific expression of the colon cancer antigen A33, a cell surface target for antibody-based therapy (1996)

Monoclonal antibody mAbA33 recognizes a unique cell surface protein of colorectal cancer, the A33 antigen. Phase I/II studies have shown highly selective targeting of radio-labeled mAbA33 in patients with metastatic colorectal cancer, opening up the possibility of A33-directed therapy. To better understand the basis of selective mAbA33 targeting in patients, the present study was designed to define the A33 distribution in normal organs and examine A33 expression in a broad range of tumor types. Immunohistochemical analysis of normal tissues identified the large and small intestinal mucosa as the principal sites of A33 expression. Tests with over 450 tumor samples showed that only tumors of the gastrointestinal tract are consistently A33-positive. For example, A33 is found in 95% of primary and metastatic colorectal cancers (86 of 90 cases tested), with uniform expression throughout the tumors in most cases. A33 was detected in a subset of gastric cancers (14/24 cases), with uniform expression in 10 cases (including 5 signer ring adenocarcinomas). Among esophageal cancers, squamous cell tumors typed A33-negative (9 cases), whereas one case each of mucinous and intestinal type was A33-positive. A subset of pancreatic carcinomas (6/12 cases) showed A33 expression, although with marked heterogeneity. Other epithelial cancers, sarcomas, neuroectodermal tumors, and lymphoid neoplasms were generally A33-negative. A33 is the first example of a constitutively expressed, organ-specific epithelial membrane antigen permitting highly specific tumor targeting in patients with colorectal cancer.
A New Memory CD27−IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic Mutation (2006)

In humans, up to 40% of peripheral B cells express CD27 and have hypermutated variable regions in their Ig genes. The CD27+ B cells are considered to be derived from germinal center following specific antigenic stimulation. Actually, somatic hypermutation in Ig genes and CD27 expression are hallmarks of memory B cells. However, the blood IgM+ IgD+ CD27+ B cells were recently associated to splenic marginal zone B cells and proposed to be a subset distinct from germinal center-derived memory B cells showing premutated Igs. The results presented herein further weaken this bona fide association because B cells expressing surface IgG, but not CD27, were found in human blood. Representing 1-4% of all peripheral B cells and approximately 25% of the IgG+ blood B cells, this population expressed mutated IgG genes showing antigenic selection characteristics but with lower mutation frequencies than that of CD27+ IgG+ B cells. However, their morphology and phenotype were similar to that of CD27+ IgG+ cells. Interestingly, the proportion of IgG2 over IgG3 transcripts was opposite in CD27- IgG+ and CD27+ IgG+ cells, suggesting distinct functions or origins. Overall, these findings extend the memory B cell reservoir beyond the CD27+ compartment and could provide further insights into B cell disorders of unknown etiology.
Azatropolones. Part II. The Schmidt Reaction of 2-Methoxy-5-methylbenzoquinone (1974)

2-Methoxy-5-methylbenzoquinone undergoes reaction with sodium azide in sulfuric acid to give (a) 3-hydroxy-6-methyl-1H-azepin-2,5-dione, which undergoes ring contraction with base to give 5-methyl-4-pyridone-2-carboxylic acid; (b) 4-methoxy-7-methyl-1H-azepin-2,5-dione, which reacts with phosphorus oxychloride to give methyl 2-chloro-6-methylpyridine-4-carboxylate, not 2-chloro-4-methoxy-7-methyl-5H-azepin-5-one; (c) 7-methoxy-4-methyl-1H-azepin-2,5-dione. The reactions of these compounds are discussed and the evidence for their structures is presented.
Optimal control of quantum-mechanical systems: Existence, numerical approximation, and applications (1988)

The optimal control of the path to a specified final state of a quantum-mechanical system is investigated. The problem is formulated as a minimization problem over appropriate function spaces, and the well-posedness of this problem is is established by proving the existence of an optimal solution. A Lagrange-multiplier technique is used to reduce the problem to an equivalent optimization problem and to derive necessary conditions for a minimum. These necessary conditions form the basis for a gradient iterative procedure to search for a minimum. A numerical scheme based on finite differences is used to reduce the infinite-dimensional minimization problem to an approximate finite-dimensional problem. Numerical examples are provided for final-state control of a diatomic molecule represented by a Morse potential. Within the context of this optimal control formulation, numerical results are given for the optimal pulsing strategy to demonstrate the feasibility of wave-packet control and finally to achieve a specified dissociative wave packet at a given time. The optimal external optical fields generally have a high degree of structure, including an early time period of wave-packet phase adjustment followed by a period of extensive energy deposition to achieve the imposed objective. Constraints on the form of the molecular dipole (e.g., a linear dipole) are shown to limit the accessibility (i.e., controllability) of certain types of molecular wave-packet objectives. The nontrivial structure of the optimal pulse strategies emphasizes the ultimate usefulness of an optimal-control approach to the steering of quantum systems to desired objectives.
Reduction of scar formation in full‐thickness wounds with topical celecoxib treatment (2003)

Adult wound repair occurs with an initial inflammatory response, reepithelialization, and the formation of a permanent scar. Although the inflammatory phase is often considered a necessity for successful adult wound healing, fetal healing studies have shown the ability to regenerate skin and to heal wounds in a scarless manner in the absence of inflammation. The cyclooxygenase-2 (COX-2) enzyme, a known mediator of inflammation, has been shown to contribute to a variety of inflammatory conditions and to the development of cancer in many organs. To examine the role of COX-2 in the wound healing process, incisional wounds were treated topically with the anti-inflammatory COX-2 inhibitor celecoxib. Acutely, celecoxib inhibited several parameters of inflammation in the wound site. This decrease in the early inflammatory phase of wound healing had a significant effect on later events in the wound healing process, namely a reduction in scar tissue formation, without disrupting reepithelialization or decreasing tensile strength. Our data suggest that in the absence of infection, adult wound healing is able to commence with decreased inflammation and that anti-inflammatory drugs may be used to improve the outcome of the repair process in the skin by limiting scar formation.
Randomized Dose-Escalation Study Evaluating Peginterferon Alfa-2a in Patients With Metastatic Malignant Melanoma (2006)

PEG-IFNalpha-2a at doses up to 450 mug once weekly has shown good tolerability and similar efficacy to conventional IFNalpha and monochemotherapy in stage IV metastatic melanoma.
Bone tissue specific transcriptional control (2000)

The specificity of hematopoietic and bone phenotypic promoters, together with the additional level of specificity inherent in the AML/CBF family of hematopoietic and osteogenic intranuclear targeting signals, offers viable options for constructing gene therapy regimens that are targeted to the skeleton for the control of metastatic disease. It is realistic to anticipate that, as additional parameters of gene regulatory mechanisms are defined, particularly components of transcriptional control that are operative within a three-dimensional context of nuclear architecture, opportunities for enhancing the effectiveness of treating patients with tumors that metastasize to bone will be extended.
ED/sup 4/I: error detection by diverse data and duplicated instructions (2002)

Errors in computing systems can cause abnormal behavior and degrade data integrity and system availability. Errors should be avoided especially in embedded systems for critical applications. However, as the trend in VLSI technologies has been toward smaller feature sizes, lower supply voltages and higher frequencies, there is a growing concern about temporary errors as well as permanent errors in embedded systems; thus, it is very essential to detect those errors. Software-implemented hardware fault tolerance (SIHFT) is a low-cost alternative to hardware fault-tolerance techniques for embedded processors: It does not require any hardware modification of commercial off-the-shelf (COTS) processors. ED/sup 4/I (error detection by data diversity and duplicated instructions) is a SIHFT technique that detects both permanent and temporary errors by executing two "different" programs (with the same functionality) and comparing their outputs. ED/sup 4/I maps each number, x, in the original program into a new number x', and then transforms the program so that it operates on the new numbers so that the results can be mapped backwards for comparison with the results of the original program. The mapping in the transformation of ED/sup 4/I is x' = k/spl middot/x for integer numbers, where k/sub f/ determines the fault detection probability and data integrity of the system. For floating-point numbers, we find a value of k/sub f/ for the fraction and k/sub e/ for the exponent separately, and use k = k/sub f//spl times/2/sup k/ for the value of k. We have demonstrated how to choose an optimal value of k for the transformation. This paper shows that, for integer programs, the transformation with k = -2 was the most desirable choice in six out of seven benchmark programs we simulated. It maximizes the fault detection probability under the condition that the data integrity is highest.
Directing Stem Cell Differentiation into the Chondrogenic Lineage In Vitro (2004)

A major area in regenerative medicine is the application of stem cells in cartilage tissue engineering and reconstructive surgery. This requires well-defined and efficient protocols for directing the differentiation of stem cells into the chondrogenic lineage, followed by their selective purification and proliferation in vitro. The development of such protocols would reduce the likelihood of spontaneous differentiation of stem cells into divergent lineages upon transplantation, as well as reduce the risk of teratoma formation in the case of embryonic stem cells. Additionally, such protocols could provide useful in vitro models for studying chondrogenesis and cartilaginous tissue biology. The development of pharmacokinetic and cytotoxicity/genotoxicity screening tests for cartilage-related biomaterials and drugs could also utilize protocols developed for the chondrogenic differentiation of stem cells. Hence, this review critically examines the various strategies that could be used to direct the differentiation of stem cells into the chondrogenic lineage in vitro.
Complete biosynthesis of opioids in yeast (2015)

Opioids are the primary drugs used in Western medicine for pain management and palliative care. Farming of opium poppies remains the sole source of these essential medicines, despite diverse market demands and uncertainty in crop yields due to weather, climate change, and pests. We engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work was conducted in a laboratory that is permitted and secured for work with controlled substances. We combined enzyme discovery, enzyme engineering, and pathway and strain optimization to realize full opiate biosynthesis in yeast. The resulting opioid biosynthesis strains required the expression of 21 (thebaine) and 23 (hydrocodone) enzyme activities from plants, mammals, bacteria, and yeast itself. This is a proof of principle, and major hurdles remain before optimization and scale-up could be achieved. Open discussions of options for governing this technology are also needed in order to responsibly realize alternative supplies for these medically relevant compounds.
Rapid Calculation of Isotope Distributions (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRapid Calculation of Isotope DistributionsAlan L. Rockwood, Steven L. Van Orden, and Richard D. SmithCite this: Anal. Chem. 1995, 67, 15, 2699–2704Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/ac00111a031https://doi.org/10.1021/ac00111a031research-articleACS PublicationsRequest reuse permissionsArticle Views1530Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium (1978)

Circadian rhythms in DNA synthesis are described for the tongue epithelium, five different regions of the alimentary canal (gut)--esophagus, stomach, duodenum, jejunum and rectum--and bone marrow in a group of BDF1 male mice. A circadian rhythm is also described for the mitotic index in the corneal epithelium in the same mice. The data document for the first time in the same animals the dramatic variation in cell division encountered from one region of the gut to another. This variation is seen in the amplitudes of the rhythms as well as in the over-all 24-hour means. On the contrary, the phasings of the rhythms in the different regions of the gut are remarkably similar. In this study, where the mice were standardized to 12 hours of light (0600-1800) alternating with 12 hours of darkness, the peak of the DNA-synthesis rhythm occurred around the time of transition from dark to light, and the trough around the time of transition from light to dark. The implications of these findings, and those of others, to the study of cell kinetics and to cancer chemotherapy are discussed.
Cells expressing a major histocompatibility complex class I molecule with a single covalently bound peptide are highly immunogenic. (1995)

The major histocompatibility complex (MHC) class I molecules expressed at the cell surface are associated with a large number of different peptides so that the density of a given MHC-peptide complex is relatively low. Here we describe the properties of MHC class I molecules genetically attached to a single antigenic peptide. Cells expressing these fusion proteins are recognized by T cells specific for the particular MHC-peptide complex. Coculture of naive splenocytes with cells expressing these MHC-peptide fusion proteins and the B7.1 antigen allows the induction of primary cytotoxic T lymphocytes (CTL) in vitro. Injection of these cells into naive mice enhances the frequency of specific CTL precursors and protects against a subsequent challenge with a tumor or a virus bearing the antigenic peptide. Soluble MHC-peptide fusions were also produced in which all three components, that is, the heavy chain, beta 2-microglobulin and the peptide, have fused into a single-chain protein. The availability of MHC class I molecules bound to a single peptide provides valuable tools for the manipulation of CTL responses and the analysis of the selection processes in the thymus.
Modelling for size-dependent and dimension-dependent melting of nanocrystals (2000)

A unified model, free of any adjustable parameters, for the size-dependence and dimension-dependence of melting point depression and superheating of nanocrystals is developed. In terms of the consideration of the surface/volume ratio of nanocrystals, the suppression of melting point of nanocrystals and superheating of embedded nanocrystals are predicted. The model predictions for the melting temperatures of nanocrystals are consistent with the experimental results and molecular dynamics simulations.