gebhart/patrepeval huggingface dataset:
Relativistic effects on an Earth‐orbiting satellite in the Barycenter Coordinate System (1985)

The general relativistic equations of motion and range measurement relations for an earth‐orbiting satellite such as LAGEOS were investigated in the barycenter coordinate system. In comparison with the Newtonian equations, modifications must be made to the satellite acceleration, the light time measurement, station clock times, and station position coordinates. Modifications to the measurement computation are also necessary in order to continue to operate formally in an earth‐centered coordinate system. Limited comparisons of data reduction results using Newtonian equations with results using the Einsteinian formulation show that estimated baselines between LAGEOS tracking stations are affected at the several centimeter level. In three of four cases, rms of fit was slightly improved using the relativistic formulation.
A Family of AMPA-Selective Glutamate Receptors (1990)

Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).
Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal Carcinoma (2010)

Patients with recurrent or refractory Epstein Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) continue to have poor outcomes. Our earlier Phase I dose escalation clinical study of 10 NPC patients showed that infusion of EBV-specific cytotoxic T cells (EBV-CTLs) was safe and had antitumor activity. To better define the overall response rate and discover whether disease status, EBV-antigen specificity, and/or in vivo expansion of infused EBV-CTLs predicted outcome, we treated 13 additional NPC patients with EBV-CTLs in a fixed-dose, Phase II component of the study. We assessed toxicity, efficacy, specificity, and expansion of infused CTLs for all 23 recurrent/refractory NPC patients treated on this Phase I/II clinical study. At the time of CTL infusion, 8 relapsed NPC patients were in remission and 15 had active disease. No significant toxicity was observed. Of the relapsed patients treated in their second or subsequent remission, 62% (5/8) remain disease free (at 17 to 75 mo), whereas 48.7% (7/15) of those with active disease had a CR/CRu (33.3%) or PR (15.4%). In contrast to locoregional disease, metastatic disease was associated with an increased risk of disease progression (HR: 3.91, P=0.015) and decreased overall survival (HR: 5.55, P=0.022). Neither the specificity of the infused CTLs for particular EBV antigens nor their measurable in vivo expansion discernibly influenced outcome. In conclusion, treatment of patients with relapsed/refractory EBV-positive NPC with EBV-CTLs is safe and can be associated with significant, long-term clinical benefit, particularly for patients with locoregional disease.
Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage (1999)

Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich region (PRR) that functions as an SH3-binding domain. Here we show that there are at least four human NUMB isoforms and that these serve two distinct developmental functions in the neuronal lineage: differentiation (but not proliferation) is promoted by human NUMB protein isoforms with a type I (short) PRR. In contrast, proliferation (but not differentiation) is directed by isoforms that have a type II (long) PRR. The two types of PRR may promote distinct intracellular signaling pathways downstream of the NOTCH receptor during mammalian neurogenesis.
Packet video for cell loss protection using deinterleaving and scrambling (1991)

A new method is presented of cell loss protection for packet video environments that uses scrambling and deinterleaving in conjunction with block transform coding of the video signal. The input video sequence is first de-interleaved by separating the sequence into subsequences using a subsampling process. This allows better prediction of lost data when packets are lost. Each subsequence is then coded using the DCT, and the coded coefficients are packetized into cells in a pseudorandom, scrambled manner. Consequently, if several adjacent cells are lost, the loss of information will be spatially and spectrally random. Because of the random nature of the lost information, recovery from cell loss and concealment of the loss data by prediction from surrounding coefficients is greatly improved. The result is an improvement in perceptual quality over existing packetization methods when cells are lost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The complement binding-like domains of the murine homing receptor facilitate lectin activity. (1991)

The leukocyte homing receptor (HR), the endothelial leukocyte adhesion molecule, and gmp140/platelet activation-dependent granule membrane protein are members of a family of adhesion molecules, termed the lectin cell adhesion molecules (LEC-CAMS) which are unified by a multi-domain structure containing a lectin motif, an epidermal growth factor-like (egf) motif, and variable numbers of a complement binding-like (CB) motif. Previous data have indicated a predominant role for the lectin motif in cell adhesion directed by the LEC-CAMS, although the egf-like domain of the HR may also play a potential role in cell binding. While the role(s) of the CB domains in the LEC-CAMS is currently not understood, they have been hypothesized to act as rigid spacers or stalks for lectin and perhaps, egf domain presentation. In this paper, we analyze the functional characteristics of murine HR-IgG chimeras containing the lectin, lectin plus egf, and lectin plus egf plus CB domains. The Mel 14 mAb, an adhesion blocking antibody which recognizes a conformational determinant in the N-terminus of the HR lectin domain, shows a significantly decreased affinity for a HR construct which lacks the CB motifs, consistent with the possibility that the CB domains are involved with lectin domain structure. In agreement with this conjecture, HR mutants lacking the CB domains show a profound decrease in lectin-specific interaction with the carbohydrate polyphosphomannan ester, suggesting that the changes in Mel 14 affinity for the lectin domain are reflected in lectin functionality. Various assays investigating the interactions between the HR deletion mutants and the peripheral lymph node high endothelium, including cell blocking, immunohistochemical staining, and radioactively labeled ligand binding, all showed that removal of the CB domains results in a lack of HR adhesive function. These results imply that the CB domains of the HR, and, by analogy, the other members of the LEC-CAM family, may play important structural roles involving induction of lectin domain conformation and resultant functionality.
A pyrolysis-mass spectrometry methodology for differentiating digested and undigested pollens applied to southeast Asian environmental samples (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA pyrolysis-mass spectrometry methodology for differentiating digested and undigested pollens applied to southeast Asian environmental samplesStephan J. DeLuca, Kent J. Voorhees, and Emory W. SarverCite this: Anal. Chem. 1986, 58, 12, 2439–2442Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/ac00125a019https://doi.org/10.1021/ac00125a019research-articleACS PublicationsRequest reuse permissionsArticle Views56Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies. (1982)

We have elicited and characterized the serological specificity of five murine monoclonal antibodies (DU-PAN-1, 2, 3, 4, and 5) to a human pancreatic tumor cell line, HPAF. The antibodies are not detecting HLA-associated antigens since all of the monoclonals failed to react with human lymphoid and myeloid cell lines and uncultured cells. All of the monoclonals except DU-PAN-5 reacted with four of five pancreatic tumor cell lines and two of two uncultured pancreatic tumors. An immunoperoxidase technique was used to determine the presence of the antigens detected by the monoclonal antibodies in frozen sections of tumor and adult and fetal normal tissues. DU-PAN-1 antigen was detected on pancreatic tumors, and a transitional cell carcinoma of the bladder, but was detected on no other adult or fetal normal tissues including pancreas. One of the antigens (DU-PAN-2) defined by the monoclonals was present on pancreatic ductal epithelial cells and showed a restricted distribution on tumor cells from some other carcinoma patients and on cells from certain fetal tissues. DU-PAN-3 antigen was present on adult and fetal pancreatic cells and certain tumor cells but could not be detected on cells of other fetal or adult normal tissues. DU-PAN-4 and DU-PAN-5 antigens have a more widespread distribution on normal or tumor cell types.
Software system for broadcasting and monitoring traffic information (2014)

The purpose of the presented project is the development of a software system for broadcasting, tracking and managing traffic related information. The system contains a server and an Android client application for reporting and displaying traffic related events (traffic cameras, traffic jams, accidents, roadblocks, etc.). It also includes a web application for the system administrators and another web application for data management and analysis. Like other similar applications, the Sparrow project uses a predefined camera database, but it also gives opportunity for the users to report events in real-time. The software system ensures several additional functionalities, such as visual and audio notifications about the approaching events and data filtering possibilities. The interface of the client application is intuitive and it is easy and safe to use while driving.
Cell-free synthesis of enzymically active tissue-type plasminogen activator. Protein folding determines the extent of N-linked glycosylation (1992)

Tissue-type plasminogen activator (t-PA) is synthesized in mammalian cells as a mixture of two forms that differ in their extent of N-linked glycosylation. We have investigated the mechanism underlying this variation in glycosylation, using a cell-free system that consists of a rabbit reticulocyte lysate optimized for the formation of disulphide bonds and supplemented with dog pancreas microsomal membranes. Molecules of human t-PA synthesized in vitro are enzymically active and responsive to natural activators and inhibitors, and are glycosylated in a pattern identical with that of the protein produced in vivo. This demonstrates that t-PA synthesized in vitro folds into the same conformation as the protein synthesized in vivo. We show that the extent of glycosylation of individual t-PA molecules is dependent on the state of folding of the polypeptide chain, since the probability of addition of an oligosaccharide side chain at Asn-184 is decreased under conditions that promote the formation of enzymically active molecules. This variation in glycosylation is independent of the rate of protein synthesis.
Synthesis of N-methyl-6-azabicyclo[3,2,1]octan-3-one, an alkaloid sub-unit (1970)

R. Furstoss, P. Teissier and B. Waegell, J. Chem. Soc. D, 1970, 384 DOI: 10.1039/C29700000384
Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma. (2013)

The monoclonal antibody against CD20, rituximab, alone, or as part of combination therapies, is standard therapy for non-Hodgkin's B-cell lymphoma. Despite significantly better clinical results obtained for beta-emitting radioimmunoconjugates (RICs), RICs targeting CD20 are not commonly used in medical practice, partly because of competition for the CD20 target. Therefore, novel therapeutic approaches against other antigens are intriguing. Here, the binding properties of a novel antibody against CD37 (tetulomab) were compared with those of rituximab. The therapeutic effect of (177)Lu-tetulomab was compared with (177)Lu-rituximab on Daudi cells in vitro. The biodistribution, therapeutic and toxic effects of (177)Lu-tetulomab and unlabeled tetulomab were determined in SCID mice injected with Daudi cells. The affinity of tetulomab to CD37 was similar to the affinity of rituximab to CD20, but the CD37-tetulomab complex was internalized 10-times faster than the CD20-rituximab complex. At the same concentration of antibody, (177)Lu-tetulomab was significantly more efficient in inhibiting cell growth than was (177)Lu-rituximab, even though the cell-bound activity of (177)Lu-rituximab was higher. Treatment with 50 and 100 MBq/kg (177)Lu-tetulomab resulted in significantly increased survival of mice, compared with control groups treated with tetulomab or saline. The CD37 epitope recognized by tetulomab was highly expressed in 216 out of 217 tumor biopsies from patients with B-cell lymphoma. This work warrants further pre-clinical and clinical studies of (177)Lu-tetulomab.
Effect of thromboxane A2 antagonists on bronchial hyperresponsiveness induced immediately after interleukin‐8 inhalation in guinea‐pigs (1997)

1. Although repeated intranasal administration of interleukin-8 (IL-8) causes bronchial hyperresponsiveness (BHR) mediated via thromboxane A2 (TXA2) and airway neutrophil accumulation in guinea-pigs, the acute effect of inhaled IL-8 is unclear. We performed this study to clarify the acute effect of IL-8 on bronchial responsiveness and the role of TXA2. 2. The effects of inhaled IL-8 on bronchial responsiveness and of the TXA2 antagonists, S-1452 (0.01 and 0.1 mg kg-1) and ONO-NT-126 (1.0 or 10 micrograms kg-1), on IL-8-induced BHR were examined by use of a modified Konzett-Rössler method in guinea-pigs. 3. Inhaled IL-8 at 100 ng ml-1, which failed to induce significant changes in Pao (pressure at the airway opening), enhanced an increase in Pao induced by subsequent inhalations of ascending doses (50-200 micrograms ml-1) of methacholine and histamine, suggesting the potentiating effect of IL-8 on bronchial responsiveness. No significant leukocyte infiltration was observed histologically sixteen minutes after the IL-8 inhalation. Both S-1452 and ONO-NT-126 reduced the IL-8-induced BHR. 4. In conclusion, IL-8 rapidly causes BHR via TXA2 release in guinea-pigs.
Prototype Alzheimer’s Disease Vaccine Using the Immunodominant B Cell Epitope from β-Amyloid and Promiscuous T Cell Epitope Pan HLA DR-Binding Peptide (2005)

Immunization of amyloid precursor protein transgenic mice with fibrillar beta-amyloid (Abeta) prevents Alzheimer's disease (AD)-like neuropathology. The first immunotherapy clinical trial used fibrillar Abeta, containing the B and T cell self epitopes of Abeta, as the immunogen formulated with QS21 as the adjuvant in the vaccine. Unfortunately, the clinical trial was halted during the phase II stage when 6% of the participants developed meningoencephalitis. The cause of the meningoencephalitis in the patients that received the vaccine has not been definitively determined; however, analysis of two case reports from the AN-1792 vaccine trial suggest that the meningoencephalitis may have been caused by a T cell-mediated autoimmune response, whereas production of anti-Abeta Abs may have been therapeutic to the AD patients. Therefore, to reduce the risk of an adverse T cell-mediated immune response to Abeta immunotherapy we have designed a prototype epitope vaccine that contains the immunodominant B cell epitope of Abeta in tandem with the synthetic universal Th cell pan HLA DR epitope, pan HLA DR-binding peptide (PADRE). Importantly, the PADRE-Abeta(1-15) sequence lacks the T cell epitope of Abeta. Immunization of BALB/c mice with the PADRE-Abeta(1-15) epitope vaccine produced high titers of anti-Abeta Abs. Splenocytes from immunized mice showed robust T cell stimulation in response to peptides containing PADRE. However, splenocytes from immunized mice were not reactivated by the Abeta peptide. New preclinical trials in amyloid precursor protein transgenic mouse models may help to develop novel immunogen-adjuvant configurations with the potential to avoid the adverse events that occurred in the first clinical trial.
Experimental Treatments of Acute Spinal Cord Injury (1969)

LTHOUGH physicians have a choice of treating acute injuries of the spinal cord by realignment of the spinal column, surgical decompression, or measures that alter neuronal metabolism and prevent or reduce edema of the cord, or by combinations of these methods, the relative merits of these procedures appear to be unknown because they have not been evaluated comparatively. There is no known experimental model to assess bony alignment, but Freeman and Wright s have described an experimental spinal cord concussion-contusion in which sufficient threshold trauma produces at least a moderately prolonged paraplegia and possibly a lasting neurological deficit and by which the relative efficacy of most current treatments could be compared. Using a similar experimental model, we evaluated standard dural decompression, direct local cord hypothermia, intramuscular dexamethasone, and intrathecal methylprednisolone.
Multiple Futures Prediction (2019)

Temporal prediction is critical for making intelligent and robust decisions in complex dynamic environments. Motion prediction needs to model the inherently uncertain future which often contains multiple potential outcomes, due to multi-agent interactions and the latent goals of others. Towards these goals, we introduce a probabilistic framework that efficiently learns latent variables to jointly model the multi-step future motions of agents in a scene. Our framework is data-driven and learns semantically meaningful latent variables to represent the multimodal future, without requiring explicit labels. Using a dynamic attention-based state encoder, we learn to encode the past as well as the future interactions among agents, efficiently scaling to any number of agents. Finally, our model can be used for planning via computing a conditional probability density over the trajectories of other agents given a hypothetical rollout of the 'self' agent. We demonstrate our algorithms by predicting vehicle trajectories of both simulated and real data, demonstrating the state-of-the-art results on several vehicle trajectory datasets.
Flex Reliability of RFID Inlays Assembled by Anisotropic Conductive Adhesive (2007)

Accompanied by the cost reduction and the assembly line speed increase, the drive to enhance the reliability of RFID tags is ever increasing due to the incremental puzzles on the tag response function. Anisotropic conductive adhesive (ACA) bonding is one of the main stream in a mass production of RFID inlay, but due to its nature of adhesive bonding and contact conduction, the increasing response problems emerges, especially when the ACA joint encounters the occasion that it needs to be flexed. A simple method to evaluate the flex reliability of the RFID inlays is developed in this study. A gold film is sputtered on the RFID flip chip to form a conductive layer, making the inlay strap becomes a conductor, and thus the contact resistance variety of ACA bonding joint can be detected. The ACA assembled inlays using this kind of dummy die are delivered to a serial tests: wind, static tensile and pure bend, while the DC resistance of these inlays is recorded simultaneously. It is found that the pure bend instead of static tensile results in irrecoverable enhancement of contact resistance of ACA joint. Besides, pure bend test with die facing down exhibit a less damage on the resistance than that with die facing up, because the former has a press effect while the latter exert a tear effect on the joint.
Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development (1996)

The mouse Engrailed, Wnt and Pax genes, which are homologues of Drosophila segmentation genes, have provided a critical genetic entry point for dissecting the molecular and cellular control of mesencephalon and metencephalon development in vertebrates. Mutant phenotypes and gene expression data suggest that six members of these gene families are required for early formation of these brain regions. Ectopic transplantation studies have shown that the midbrain-hindbrain-junction protein can act as an organizer and recruit certain host cells to re-establish parts of the entire region. Taken together, these studies indicate that the mesencephalon and metencephalon develop as one independent unit, and that the genetic network regulating development of this region involves conserved genes that control segmentation in Drosophila. By analogy, segmentation of the rest of the brain might best be described in terms of 'genetic units' defined by genetic and transplantation data.
An implant to empty the bladder or close the urethra. (1977)

An implant has been designed which, in the baboon, will empty the bladder almost completely, or close the urethra so that urine does not leak out despite a contraction of the detrusor muscle. Electrodes on the 1st and 2nd sacral anterior nerve roots (corresponding roughly to the 3rd and 4th sacral in man) suffice for both actions. Closing the urethra or emptying the bladder artificially in this way seems to cause conscious, neurologically intact, baboons no discomfort. Implants have remained in place for over two years, and have emptied the bladder artificially 12 times a day for many weeks, without deterioration of function.
Consumer Financial Privacy and the Gramm-Leach-Bliley Act (2002)

By requiring financial institutions to put adequate controls in place to secure consumers? confidential data and by clearly spelling out what rights consumers and financial institutions have, the 1999 Gramm-Leach-Bliley Act is a positive step toward ensuring consumer financial privacy. If there are no market imperfections, then competition may be relied on to efficiently sort out the competing interests of consumers and financial institutions. Alternatively, if there are market imperfections in the form of externalities, the Coase theorem suggests that the act, by clearly assigning property rights to the information, should facilitate an economically efficient outcome.