gebhart/patrepeval huggingface dataset:
Improved Nonthoracotomy Defibrillation Based on Ventricular Fibrillation Waveform Characteristics (1996)

The heart has been shown to be more susceptible to defibrillation at a higher absolute ventricular fibrillation voltage (AVFV) measured on the surface ECG. This study evaluated in a closed-chest canine model (n = 7) the clinical applicability of using a real-time VF waveform analysis system using an electrogram defined between the generator can and an RV endocardial electrode. Under fluoroscopic guidance, superior vena cava and RV spring coil catheter electrodes were inserted through the external jugular vein. A subcutaneous patch was placed on the left chest. A two-parameter tracking algorithm was used to dynamically identify the high AVFV area, and a biphasic shock was triggered synchronously at the next peak. The performance of this new peak shock method (PSM) was compared to the conventional method of shocking at a fixed time in 175 paired trials. Five shocks per voltage and five voltages per animal were randomized between the two methods to permit the generation of sigmoidal dose response curves for the estimation of 50% (E50), 75% (E75), and 100% (E100) success energies. Induction of VF and discharge voltage were kept constant while energy delivered, impedance (R), and AVFV at the point of shock were measured. Energy (8.63 +/- 0.40 vs 8.64 +/- 0.40 J), R (48.60 +/- 0.30 vs 48.59 +/- 0.30 omega), and current (7.50 +/- 0.18 vs 7.51 +/- 0.16 A) were not significantly different between trials for either the conventional or the PSM. The time from the onset of VF until the defibrillation shock was 7.98 +/- 1.44 seconds. Higher overall successes (46.3% vs 33.1%; P < 0.01) and lower E50, E75, and E100 were observed for the PSM. Finally, the significantly higher AVFV (9.12 +/- 0.32 vs 4.73 +/- 0.34 mV; P < 0.0001) with the peak method suggests that the high VF voltage could be detected as it occurred in real-time. The improved defibrillation success supports the use of this method for nonthoracotomy defibrillation.
Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells. (1996)

Growth factors have been demonstrated to regulate the proliferation and viability of a number of cell lineages. Because most drugs used in chemotherapy kill cells through programmed cell death, by the process of apoptosis, we determined whether growth factors, specifically epidermal growth factor (EGF) and lysophosphatidic acid (LPA), which we have demonstrated recently to be a potent growth factor for ovarian cancer cells, would alter the ability of cis-diamminedichloroplatinum (cis-DDP), the most effective chemotherapeutic agent for ovarian cancer, to kill the HEY ovarian cancer cell line. We demonstrate that both EGF and LPA decrease the ability of cis-DDP to kill HEY ovarian cancer cells as assessed by colony-forming cell activity and dye reduction. Morphological changes, DNA release, and electron microscopy suggested that LPA and EGF protect ovarian cancer cells from programmed cell death induced by cis-DDP. Because LPA is present in high levels in ascitic fluid from ovarian cancer patients, and the EGF receptor is expressed by tumor cells from a significant portion of patients where it correlates with prognosis, growth factor modulation of cis-DDP-induced apoptosis may play a role in the poor prognosis associated with ovarian cancer.
The analysis of anisocoria. The use of photography in the clinical evaluation of unequal pupils. (1979)

Unequal pupils are common and can be difficult to sort out. A flow chart is presented to help in localizing the cause for anisocoria. Also, an inexpensive and simple camera is suggested for use in accurately measuring pupils.
Ohio State University at the 2004 DARPA Grand Challenge: developing a completely autonomous vehicle (2004)

The DARPA Grand Challenge is a field test designed to accelerate R&D in autonomous ground vehicles that save lives on the future battlefield. At Ohio State University, we have extensive experience in developing autonomous ground vehicles. Our goal was to create a completely autonomous vehicle that could negotiate most of the GC 04 route and perhaps even finish the race. To achieve our goal, we needed to conquer three main technical challenges. The first was to install drive-by-wire technology in the vehicle and to modify the vehicle to fulfill DARPA safety requirements. The second challenge was to provide sensing and information fusion algorithms. The third challenge was control.
Thrombopoietin Stimulates Myelodysplastic Syndrome Granulocyte-Macrophage and Erythroid Progenitor Proliferation (1998)

Thrombopoietin (TPO) has been successfully used to stimulate megakaryocyte progenitor proliferation and platelet production both in vitro and in vivo. We and other investigators have found that TPO also stimulates normal marrow colony-forming unit granulocyte-macrophage (CFU-GM) and burst-forming unit-erythroid (BFU-E) growth. In contrast to its effect on normal marrow precursors, TPO stimulates acute myelogenous leukemia (AML) progenitor proliferation in only 25% of the cases. Because the hematopoietic cells in Myelodysplastic syndrome (MDS) originate from both the normal and leukemic clones, we hypothesized that TPO may be a useful therapeutic agent for MDS. To test this hypothesis, we used fresh marrow samples taken from 14 MDS patients. We found that in the presence of fetal calf serum (FCS) and erythropoietin (EPO) TPO (5 to 40 ng/ml) MDS CFU-GM and BFU-E colony-forming cell proliferation were stimulated in a dose-dependent fashion by up to 103% and 93% respectively. This effect was similar to the stimulation obtained with optimal concentrations of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage CSF (GM-CSF), or interleukin-3 (IL-3). Furthermore, TPO increased the colony-stimulatory effects of G-CSF, GM-CSF, IL-3, and stem cell factor (SCF) on MDS marrow cells. However, depletion of either T lymphocytes or adherent cells abrogated the effect of TPO, suggesting that the effect is not a direct one but is mediated through interaction with cytokines produced by accessory cells. Taken together, our data suggest that the therapeutic role of TPO in the management of MDS warrants further investigation.
Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. (1998)

To investigate the epithelial nature of primary and SV40 virus-immortalized human corneal epithelial (CEPI) cells and to study a variety of functional responses to some key inflammatory agents (bradykinin [BK], histamine, and platelet-activating factor [PAF]) and their antagonists in these cells.Primary CEPI (P-CEPI) and clone 4 of the SV40 virus-immortalized (CEPI-17-CL4) cells were analyzed for their interaction with several monoclonal antibodies selective for various cytokeratins to define their immunocytochemical characteristics and phenotypic traits. Both cell types were tested for their ability to respond to BK, histamine, and PAF and their antagonists, using the production of [3H]inositol phosphates ([3H]IPs) as an index of receptor activation. The ability of BK, PAF, and histamine to stimulate cytokine release and the induction of mRNA for matrix metalloproteinase-1 (MMP-1) were also studied using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction techniques, respectively.P-CEPI and CEPI-17-CL4 cells were both shown to possess the epithelial cell cytokeratins labeled with AE1 and AE3 antibodies. The potencies (EC50s) of BK, histamine, and PAF were similar for stimulating [3H]IPs production in P-CEPI and CEPI-17-CL4 cells: BK = 2.27 to 2.99 nM, PAF = 17.1 to 18.26 nM, and histamine = 1.65 to 5.74 microM (all n = 3 to 6). Both cell types also responded similarly to receptor-selective antagonists for BK, PAF, and histamine (Hoe-140: Ki = 10.1 to 11.9 nM; PCA-4248: Ki = 315 to 421 nM; triprolidine: Ki = 0.8 to 4.76 nM; all n = 5 to 10). Histamine (100 microM) and interleukin-1alpha (IL-1alpha, 10 ng/ml) significantly stimulated IL-6 and granulocyte macrophage colony-stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells.These studies have shown that the primary and immortalized human corneal epithelial cells express functional BK (a B2 subtype), histamine (an H1 subtype), and PAF receptors and exhibit very similar immunocytochemical, signal transduction, and pharmacological properties. Therefore, the CEPI-17-CL4 cells (currently at passage 220) appear to provide a useful representative in vitro model system to study the physiological and pathologic aspects of the human corneal epithelium.
Protein Biomarkers for the Early Detection of Breast Cancer (2011)

Advances in breast cancer control will be greatly aided by early detection so as to diagnose and treat breast cancer in its preinvasive state prior to metastasis. For breast cancer, the second leading cause of cancer-related death among women in the United States, early detection does allow for increased treatment options, including surgical resection, with a corresponding better patient response. Unfortunately, however, many patients' tumors are diagnosed following metastasis, thus making it more difficult to successfully treat the malignancy. There are, at present, no existing validated plasma/serum biomarkers for breast cancer. Only a few biomarkers (such as HER-2/neu, estrogen receptor, and progesterone receptor) have utility for diagnosis and prognosis. Thus, there is a great need for new biomarkers for breast cancer. This paper will focus on the identification of new serum protein biomarkers with utility for the early detection of breast cancer.
Programming Human Dendritic Cells with mRNA (2012)

Transfecting with in vitro transcribed, protein-encoding mRNA is a simple yet effective method to express high levels of the desired RNA-encoded proteins in primary cells. Cells can be transfected with antigen-encoding mRNA, which is translated into protein and is processed by the cellular antigen-processing pathway to generate antigen-presenting cells. Another elegant and increasingly popular application is to transfect cells with mRNA that encodes immune modulating molecules (cytokines, chemokines, toll-like receptors (TLRs), immune receptor ligands, immune receptor targeting antibodies) which, when translated into protein, can program cell behavior and/or function. In this chapter we describe an efficient method to deliver mRNA into human dendritic cells (DCs) by electroporation. This is currently the method of choice to deliver mRNA into antigen-presenting cells for generating vaccines for cancer immunotherapy.
STUDIES ON HYBRID STERILITY. II. LOCALIZATION OF STERILITY FACTORS IN DROSOPHILA PSEUDOOBSCURA HYBRIDS (1936)

Uploaded by Plazi for TaxoDros. We do not have abstracts.
HSV LAT AND NEURONAL SURVIVAL (2004)

Herpes Simplex Virus (HSV) establishes a latent infection within sensory neurons and periodically reactivates in response to stress. HSV's ability to inhabit neurons for the life of the host involves a number of virally encoded functions that tightly regulate the latency-reactivation cycle, preventing uncontrolled spread of reactivating virus and large-scale death of neurons. The HSV latency-associated transcript (LAT) is a complex transcription unit expressed primarily in neurons containing latent genomes. While mutational analyses indicate LAT is nonessential for viral replication, the 5' exon of LAT greatly enhances reactivation. Several studies have also identified LAT mutations that reduce establishment of latency and enhance virulence. Recently, LAT has also been shown to inhibit cell death through by blocking caspase-8 and caspase-9 pathways. While blocking apoptosis is not essential for either establishment of latency or reactivation, it likely augments these processes and may contribute to HSV's long-term persistence and spread.
Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109 (2006)

Following the discovery of a new series of benzimidazole derivatives bearing a diarylmethyl group as inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp),1,2 we extended the structure-activity relationship (SAR) study to analogues bearing a substituted biphenyl group and succeeded in a significant advancement of activity. Starting from compound 1, optimization of the A, B, and C rings afforded potent inhibitors with low nanomolar potency against genotype 1b NS5B. The compounds, which have a substituent with a carbonyl function at the 4-position of the B-ring, efficiently blocked subgenomic viral RNA replication in the replicon cell assay at low submicromolar concentrations. Among the new compounds, compound 10n (JTK-109) exhibited favorable pharmacokinetic profiles, high selectivity for NS5B, and good safety profiles, suggesting the potential for a clinical candidate in the treatment of hepatitis C.
Baker's yeast mediated transformations in organic chemistry (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBaker's yeast mediated transformations in organic chemistryRene. Csuk and Brigitte I. GlaenzerCite this: Chem. Rev. 1991, 91, 1, 49–97Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/cr00001a004https://doi.org/10.1021/cr00001a004research-articleACS PublicationsRequest reuse permissionsArticle Views4059Altmetric-Citations553LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A "hybrid intelligent network (IN)" solution for local number portability (LNP) (or how you can take it with you) (2002)

Market research indicates that a major hurdle to successfully entering the local exchange business today is the lack of number portability, i.e., the subscriber's existing telephone number is tied to a specific central office switch and cannot be ported to a different service provider's switch. Therefore, competition in the local loop is inextricably linked to the ability to retain one's telephone number when switching service providers, especially in the case of business customers. Thus, the concept of local number portability (LNP) is gaining momentum in the industry. The article first defines the various flavors of LNP and the current focus of the industry. The network implications of LNP are then described. Using this as background, the objectives for a generic and flexible LNP solution that minimizes network impacts are formulated. A "hybrid IN" solution that meets the objectives is then developed. The solution is hybrid in the sense that it uses AIN 0.1 triggers and messages for providing the basic call processing while using an AIN 0.0 Enhanced 800-like (E800-like) query/response messaging technique for proper feature operations. Various call scenarios are presented to show how calls involving LNP subscribers are processed using this solution. An interaction scenario for the CLASS Automatic Callback/Automatic Recall feature is shown to demonstrate the use of the generic E800-like messaging technique in providing correct feature operations. Possible evolutions of the solution are noted.
ROS and ROS‐Mediated Cellular Signaling (2016)

It has long been recognized that an increase of reactive oxygen species (ROS) can modify the cell-signaling proteins and have functional consequences, which successively mediate pathological processes such as atherosclerosis, diabetes, unchecked growth, neurodegeneration, inflammation, and aging. While numerous articles have demonstrated the impacts of ROS on various signaling pathways and clarify the mechanism of action of cell-signaling proteins, their influence on the level of intracellular ROS, and their complex interactions among multiple ROS associated signaling pathways, the systemic summary is necessary. In this review paper, we particularly focus on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins (NF-κB, MAPKs, Keap1-Nrf2-ARE, and PI3K-Akt), ion channels and transporters (Ca(2+) and mPTP), and modifying protein kinase and Ubiquitination/Proteasome System.
Selectivity in the Inhibition of HIV and FIV Protease: Inhibitory and Mechanistic Studies of Pyrrolidine-Containing .alpha.-Keto Amide and Hydroxyethylamine Core Structures (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelectivity in the Inhibition of HIV and FIV Protease: Inhibitory and Mechanistic Studies of Pyrrolidine-Containing .alpha.-Keto Amide and Hydroxyethylamine Core StructuresDeborah H. Slee, Karen L. Laslo, John H. Elder, Ian R. Ollmann, Alla Gustchina, Jukka Kervinen, Alexander Zdanov, Alexander Wlodawer, and Chi-Huey WongCite this: J. Am. Chem. Soc. 1995, 117, 48, 11867–11878Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00153a008https://doi.org/10.1021/ja00153a008research-articleACS PublicationsRequest reuse permissionsArticle Views583Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Tunable diode protection for GMR and TMR sensors (2007)

TMR and GMR sensors used today are highly susceptible to ESD damage with failure voltages as low as 0.5 V. Diode protection using a single diode connected in parallel with the sensor does not work for many advanced MR sensors due to the fact that the voltage at which diodes begin conducting significant current exceeds the damage voltage of many advanced MR sensors. This is due to limitations of the band gaps of the diode materials (Si and Ge) and the resistance of the diodes while conducting. Here we report several novel diode protection circuits which enable protecting the most sensitive devices while tuning the circuits to the electrical characteristics of the particular sensor being used.
Towards 3D object recognition via classification of arbitrary object tracks (2011)

Object recognition is a critical next step for autonomous robots, but a solution to the problem has remained elusive. Prior 3D-sensor-based work largely classifies individual point cloud segments or uses class-specific trackers. In this paper, we take the approach of classifying the tracks of all visible objects. Our new track classification method, based on a mathematically principled method of combining log odds estimators, is fast enough for real time use, is non-specific to object class, and performs well (98.5% accuracy) on the task of classifying correctly-tracked, well-segmented objects into car, pedestrian, bicyclist, and background classes. We evaluate the classifier's performance using the Stanford Track Collection, a new dataset of about 1.3 million labeled point clouds in about 14,000 tracks recorded from an autonomous vehicle research platform. This dataset, which we make publicly available, contains tracks extracted from about one hour of 360-degree, 10Hz depth information recorded both while driving on busy campus streets and parked at busy intersections.
Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes (2012)

ClinicalTrials.gov NCT00607230.
Solid phase synthesis of hydrogen bond surrogate derived α-helices: resolving the case of a difficult amide coupling (2010)

Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described.
Optical manipulation of rod-shaped bacteria and adhesive cellular clusters with novel “tug-of-war” optical tweezers (2014)

We design a new type of “tug-of-war” optical tweezers with lateral pulling forces and demonstrate full control of rod-shaped and asymmetric bacteria, including breaking up adhesive cellular clusters inhabiting aqueous media.
A Comparison Between Stereo-Vision Techniques for the Reconstruction of 3-D Coordinates of Objects (2006)

This paper deals with the problems in setting up stereo-vision systems for contactless measurement of dimensional parameters in industrial environments. Two implicit calibration algorithms for the reconstruction of three-dimensional (3-D) real-world coordinates of objects from pairs of two-dimensional image coordinates have been implemented and compared. The former is based on a direct linear transformation, while the latter on an Artificial Neural Network (ANN). The results of the comparison made on artificial and real objects are finally reported in terms of statistical analysis of the reconstruction error
A fluorescent stilbenoid dendrimer for solution-processed blue light emitting diodes (2008)

We report a solution processed blue stilbenoid dendrimer based on a 1, 3, 5 - benzene core and endowed with a periphery of electron donating and solubilizing alkoxy chains. Raman analysis it is revealed as a helpful tool to investigate changes from the pristine material to the material in the OLED structure, explaining the differences between the dendrimer single layer thin film photoluminescence (PL) and the electroluminescence (EL) dendrimer active layer emission in the device. We report a blue EL emission (439 nm) and a very promising effective mobility value of 2.55 &times; 10<sup>-5</sup> cm<sup>2</sup>/(V&bull;s) suggesting good transport properties for non doped blue OLEDs that use air stable Al as the cathode.