gebhart/patrepeval huggingface dataset:
利用高速、大容量FPGA的片上RAM实现155Mbps ATM (1999)

高速数据通迅应用,如155Mbps异步传输模式(ATM),需要速率相应的Buffers或FIFOs。利用现今高速、大容量FPGA上集成的大量RAM,开发人员可以满足这些需求而无需使用外置FIFOs。本文是一个基于FPGA的ADSL的设计实例,它在FPGA上采用了UTOPIA ATM接口并利用片上RAM构成了FIFOs。 互联网的流行,呼唤新的网络技术,以便能提供更高带宽的连接。Cisco system所提供的ADSL网络产品包括ADSL局端复用器、桥接器、路由器及调制解调器卡。 这些Cisco system的产品(PCIRunner,SpeedRunner及FireRunner)提供了ADSL数据流和ATM UTOPIA—1总线间的连接桥。该桥能完成ATM传输汇聚(TC)子层的功能。传输汇聚子层主要完成如图1所示的五项主要功能。
ApoE ϵ3‐haplotype modulates Alzheimer beta‐amyloid deposition in the brain (2002)

ApoE epsilon4 allele increases the risk of late-onset Alzheimer disease (AD) as well as the amount of beta-amyloid deposition in the brain. Because half of AD patients do not have ApoE epsilon4, it is important to search for other determinants of ApoE that modify AD risk. We tested whether the haplotype background of the most common ApoE allele, epsilon3, influences brain amyloid deposition or the risk of neuropathologically verified AD in a population-based sample of elderly Finns. To exclude the effects of ApoE protein polymorphism we focused these analyses on subjects homozygous for epsilon3. Haplotypes were defined using polymorphisms at positions - 491 and -219 of the ApoE promoter and at position +113 of intron-1. We found that epsilon3-haplotypes containing the promoter allele -219T were associated with reduced amyloid deposition and reduced risk of neuropathologically verified AD as compared to epsilon3-haplotypes containing -219G. The functional polymorphism(s) responsible for the haplotypic difference remains to be identified. These results indicate that there is significant allelic variation in the ApoE gene region, which modulates brain amyloid deposition and AD risk, independent of the ApoE protein polymorphism.
Photolabile precursors of biological amides: synthesis and characterization of caged o-nitrobenzyl derivatives of glutamine, asparagine, glycinamide, and .gamma.-aminobutyramide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotolabile precursors of biological amides: synthesis and characterization of caged o-nitrobenzyl derivatives of glutamine, asparagine, glycinamide, and .gamma.-aminobutyramideDoraiswamy Ramesh, Raymond Wieboldt, Andrew P. Billington, Barry K. Carpenter, and George P. HessCite this: J. Org. Chem. 1993, 58, 17, 4599–4605Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/jo00069a021https://doi.org/10.1021/jo00069a021research-articleACS PublicationsRequest reuse permissionsArticle Views750Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silver Iontophoretic Catheter: A Prototype of a Long-Term Antiinfective Vascular Access Device (1996)

A silver iontophoretic catheter (SIC) was developed consisting of two electrically charged parallel silver wires helically wrapped around the proximal segment of a vascular catheter. In vitro and in vivo activities of this catheter were compared with those of an aseptic catheter coated with chlorhexidine and silver sulfadiazine (CH/SS). The SIC demonstrated broad-spectrum in vitro inhibitory activity against bacteria and Candida albicans comparable to that of the CH/SS-coated catheter. The durability of activity was determined by incubating catheters in serum at 37 degrees C for various time intervals. After 30 days, the antimicrobial activity of the SIC did not change significantly, while that of the CH/SS-coated catheter was reduced to a suboptimal level. In a rabbit model, the SIC was safe and significantly more efficacious than the CH/SS-coated catheter in preventing colonization with Staphylococcus aureus (P < .05). The SIC has broad-spectrum inhibitory activity of long durability and is highly efficacious in preventing colonization in vivo.
Narcolepsy: Diagnosis and management (2018)

Narcolepsy is a chronic disorder of hypersomnia that can have a significant impact on quality of life and livelihood. However, with appropriate treatment, its symptoms are manageable, and a satisfying personal, social, and professional life can still be enjoyed. Greater awareness of the disorder promotes accurate and efficient diagnosis. With ongoing research into its underlying biology, better treatments for narcolepsy will inevitably become available.
3F8 monoclonal antibody treatment of patients with stage 4 neuroblastoma: a phase II study. (1998)

3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotension and anaphylactoid reactions were self-limited and manageable. Three pts are long-term survivors between 79-130+ months after 3F8 treatment without additional systemic therapy and no delayed neurological complications. The potential benefits of 3F8 when added to chemoradio-therapy warrant further investigation.
Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [18F]Fluorodeoxyglucose–Positron-Emission Tomography Study with Partial Volume Effects Correction: Fig 1. (2011)

Our findings suggest that age-related functional brain variability in cognitively healthy elderly individuals is largely secondary to the degree of regional brain atrophy, and the findings provide support to the notion that appropriate PVE correction is a key tool in neuroimaging investigations.
Nutritional effects on resumption of ovarian cyclicity and conception rate in postpartum dairy cows (2001)

Abstract Increased genetic potential for milk production has been associated with a decline in fertility of lactating cows. Following parturition the nutritional requirements increase rapidly with milk production and result in negative energy balance (NEBAL). NEBAL delays the time of first ovulation thereby affecting ovarian cycles before and during the subsequent breeding period The effects of NEBAL on reinitiation of ovulation are manifested through inhibition of LH pulse frequency and low levels of glucose, insulin and IGF-I in blood that collectively restrain oestrogen production by dominant follicles. Upregulation of LH pulses and peripheral IGF-I in association with the NEBAL nadir increases the likelihood that emerging dominant follicles will ovulate. The legacy of NEBAL is reduced fertility after insemination in conjunction with reduced serum progesterone concentrations. Diets high in crude protein support high milk yield, but may be detrimental to reproductive performance. Depending upon protein quantity and composition, serum concentrations of progesterone may be lower and the uterine luminal environment is altered. High protein intake is correlated with plasma urea concentrations that are inversely related to uterine pH and fertility. The direct effects of high dietary protein and plasma urea on embryo quality and development in cattle are inconsistent. In conclusion, the poor fertility of high producing dairy cows reflects the combined effects of a uterine environment that is dependent on progesterone, but has been rendered suboptimal for embryo development by antecedent effects of negative energy balance and may be further compromised by the effects of urea resultingfrom intake of high dietary protein.
Elucidation of muscle‐binding peptides by phage display screening (1999)

Muscle makes up the largest tissue volume of the body, yet its size makes muscle-specific therapy difficult. This becomes particularly relevant when approaches to gene therapy for inherited myopathies are evaluated. Thus, a mechanism to target constructs or pharmaceuticals to muscle following intravenous injection would be advantageous. By screening a random phage display library we have identified a heptapeptide sequence, ASSLNIA, with enhanced in vivo skeletal and cardiac muscle binding. Phage carrying this peptide showed a 9- to 20-fold (depending on control tissue) increase in muscle selectivity compared with phage with no insert. When the injected individual phage clone was localized by immunohistochemistry, it was found within focal areas of the membrane of myofibers. Thus, the peptide identified represents a ligand that is capable of accessing skeletal and cardiac muscle from the lumen of blood vessels and could therefore readily be exploited for targeted delivery to muscle cells. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 460–466, 1999.
Mind how you answer me! (2011)

In this paper we propose a new biometric measure to authenticate the user of a smartphone: the movement the user performs when answering (or placing) a phone call. The biometric measure leverages features that are becoming commodities in new smartphones, i.e. accelerometer and orientation sensors. We argue that this new biometric measure has a unique feature. That is, it allows a transparent authentication (not requiring an additional specific interaction for this) to check that the user that is answering (or placing) a phone call is the one authorized to do that. At the same time, this biometric measure can also be used as a non transparent authentication method, e.g. the user may need to move the phone as if answering a call, in order to unlock the phone to get access to SMSs or emails. As a consequence of being a biometric measure, an adversary that spies on the movement (e.g. captures it with a camera) and tries to replicate it, will not be granted access to the phone.
Infliximab treatment results in significant improvement in the quality of life of patients with severe psoriasis: a double-blind placebo-controlled trial (2005)

Infliximab induction therapy resulted in significant improvement in HRQOL in patients with severe psoriasis.
Amplification of Dynamic Chiral Crown Ether Complexes During Cyclic Acetal Formation (2003)

The dynamic duo: A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6-disubstituted 1,3,5,7-cis-tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (>95 % yield, see schematic representation) relative to kinetic syntheses (<8 % yields in their macropolycyclization steps), even when the same template was used. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51558_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Vortex states in superconducting rings (2000)

The superconducting state of a thin superconducting disk with a hole is studied within the nonlinear Ginzburg-Landau theory in which the demagnetization effect is accurately taken into account. We find that the flux through the hole is not quantized, the superconducting state is stabilized with increasing size of the hole for fixed radius of the disk, and a transition to a multivortex state is found if the disk is sufficiently large. Breaking the circular symmetry through a non-central-location of the hole in the disk favors the multivortex state.
Recent progress in the biochemistry of plant steroids other than sterols (Saponins, glycoalkaloids, pregnane derivatives, cardiac glycosides, and sex hormones) (1974)

Abstract Recent studies concerning the biosynthesis, metabolism, and possible functions of steroids other than sterols in plants are reviewed and discussed. These studies embrace the saponins, glycoalkaloids, pregnane derivatives, cardiac glycosides, as well as their aglycones, and the sex hormones.
Deletion map of the Escherichia coli structural gene for alkaline phosphatase, phoA (1981)

Lambda transducing phages containing portions of the phoA gene have been isolated and used to construct a deletion map of the phoA gene. The isolation of a plaque-forming lambda transducing phage carrying the entire phoA gene is also described. Two new methods for screening or selection of mutants that have altered levels of alkaline phosphatase activity are reported.
A New Biodegradable Patch for Closure of Atrial Septal Defect: An Experimental Study (1992)

Biodegradable patches made from polyhydroxybutyrate (PHB) were used to close experimentally induced atrial septal defect in six calves. The implants were evaluated after 3-12 months macroscopically and by light and scanning electron microscopy with regard to regeneration of tissue and degradation of the polymer. At implant degradation, complete endothelial layers facing the right and left atrium were observed, with a subendothelial layer of collagen and some smooth-muscle cells. The patch was degraded by polynucleated macrophages, and 12 months postoperatively no polymer material was identifiable at ordinary light microscopy, but in polarized light small particles of polymer with persisting foreign body reaction were still seen. Scanning electron microscopy revealed a complete layer of surface cells with morphologic signs of endothelium. There was no shunt or sign of infection. Biodegradable PHB patches implanted in atrial septal defects in this experimental model thus prompted formation of regenerated tissue that macroscopically and microscopically resembled native atrial septal wall. The total degradation time exceeded 12 months.
Gaussian profile estimation in one dimension (2007)

We extend recent results for estimating the parameters of a one-dimensional Gaussian profile to two-dimensional profiles, deriving the exact covariance matrix of the estimated parameters. While the exact form is easy to compute, we provide a set of close approximations that allow the covariance to take on a simple analytic form. This not only provides new insight into the behavior of the estimation parameters, but also lays a foundation for clarifying previously published work. We also show how to calculate the parameter variances for the case of truncated sampling, where the profile lies near the edge of the array detector. Finally, we calculate expressions for the bias in the classical formulation of the problem and provide an approach for its removal. This allows us to show how the bias affects the problem of choosing an optimal pixel size for minimizing parameter variances.
Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. (1991)

Three forms of basic fibroblast growth factor (bFGF), initiated at an AUG (18 kDa) and two CUG (21 and 22.5 kDa) start codons, were produced following transfection of COS cells with human hepatoma bFGF cDNA. The subcellular localization of the different forms was investigated directly or by using chimeric genes constructed by fusion of the bFGF and chloramphenicol acetyltransferase open reading frames. The AUG-initiated proteins were cytoplasmic, while the CUG-initiated forms were nuclear. The signal sequence responsible for the nuclear localization of bFGF is contained within 37 amino acid residues between the second CUG and the AUG start codons. Alternative initiation of translation regulates the subcellular localization of bFGF and thus could modulate its role in cell growth and differentiation control.
Formation and Degradation of Poly(D,L‐lactide) Nanoparticles and Their Potential Application as Controllable Releasing Devices (2004)

In the presence of surfactant, water-insoluble poly(D,L-lactide) (PLA) was dispersed into narrowly distributed nanoparticles stable in water via microphase inversion. The structure and degradation of such formed nanoparticles were investigated by a combination of static and dynamic laser light scattering. Our results revealed that the degradation rate increased with the temperature and pH so that the degradation could be regulated from minutes to days. Using anionic sodium dodecyl sulfate (SDS) as stabilizer resulted in a slower degradation than using cationic hexadecyltrimethylammonium bromide (HTAB). The phthalocyanine chromophores (PC) could be encapsulated inside these PLA nanoparticles. The degradation of individual PLA nanoparticles led to a controllable releasing of PC. The absorption and fluorescence studies revealed a correlation between the degradation and the releasing of PC. Our results showed that a higher PC/PLA ratio could lead to a faster degradation.
Probing structure and function of VLDL by synthetic amphipathic helical peptides (1996)

Class A amphipathic helical peptides have been shown to mimic many properties of exchangeable apolipoproteins. The three analogs of the class A amphipathic peptides were used to probe the structure and function of human very low density lipoproteins (VLDL): 1) 18 residue peptide possessing a single helical domain (18A) with the sequence Asp-Trp-Leu-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Leu-Lys-Glu-Ala-Phe; 2) two domains of 18A separated by a Pro (37pA); and 3) and 18A analog with the end groups protected to increase helicity (Ac-18A-NH2). Upon incubation of the peptides with VLDL at a peptide to VLDL, (protein) ratio of 1:1, the 37pA and Ac-18A-NH2 were able to displace most of apolipoprotein (apo) Cs and E from VLDL without alteration in its lipid composition and morphology while 18A had minimal effect. The extent of displacement was a function of the peptide to VLDL ratio. The rank order of displaceability of apolipoproteins on VLDL was apoE > C-III > C-II. The displacement of apoE and/or Cs from VLDL by peptides variably affected the ability of VLDL to interact with purified bovine milk lipoprotein lipase (LpL) and cultured macrophages. Treatment of VLDL with Ac-18A-NH2 markedly lowered its reactivity to LpL and its ability to induce lipid accumulation in cultured macrophages: however, treatment of VLDL with 37pA or 18A only minimally lowered their abilities. Ac-18A-NH2 treatment of VLDL resulted in the increase of apparent K(m) and a decrease of Vmax for lipoprotein lipase (LpL)-catalyzed hydrolysis of VLDL triglycerides. When an artificial triglyceride emulsion was used as a substrate of LpL, 37pA, but not Ac-18A-NH2, activated LpL. The above data indicate that 1) amphipathic helical peptides can alter the metabolic and functional properties of VLDL by dissociating the functionally important exchangeable apolipoproteins from VLDL as well as by acting as a functional element of VLDL after their incorporation; and 2) the class A amphipathic peptides having different lipid-associating properties exert significantly different effect on VLDL function.
On some recent applications of the Coanda effect to acoustics. (2010)

Over the last half century or so, the Coanda effect (which causes a jet of fluid to follow a curved surface) has been increasingly widely observed in a variety of applications including medicine, industry, maritime, and the natural world. Devices employing this effect usually offer substantial flow deflection and enhanced turbulence levels and entrainment compared with conventional jet flows. However, these prospective advantages are generally accompanied by other significant disadvantages such as flow detachment and a considerable increase in associated noise levels. This paper details some of these applications and discusses why the increased noise levels associated with this principle meant that its full potential is yet to be realized, and how these can be mitigated.
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation (2002)

The Notch family of cell surface receptors plays a key role in cell-fate determination and differentiation, functioning in a cell- and context-specific manner. In mammalian cells, Notch activation is generally thought to maintain stem cell potential and inhibit differentiation, thereby promoting carcinogenesis. However, in other contexts such as primary epithelial cells (keratinocytes), increased Notch activity causes exit from the cell cycle and/or commitment to differentiation. We now report that expression of the endogenous Notch1 gene is markedly reduced in a panel of cervical carcinoma cells whereas expression of Notch2 remains elevated, and Notch1 expression is similarly reduced or absent in invasive cervical cancers. Conversely, expression of activated Notch1 causes strong growth inhibition of HPV-positive, but not HPV-negative, cervical carcinoma cells, but exerts no such effects on other epithelial tumor cells. Increased Notch1 signaling, but not Notch2, causes a dramatic down-modulation of HPV-driven transcription of the E6/E7 viral genes, through suppression of AP-1 activity by up-regulation of the Fra-1 family member and decreased c-Fos expression. Thus, Notch1 exerts specific protective effects against HPV-induced transformation through suppression of E6/E7 expression, and down-modulation of Notch1 expression is likely to play an important role in late stages of HPV-induced carcinogenesis.
Cellular Catabolism of Lipid Poor Apolipoprotein E via Cell Surface LDL Receptor-Related Protein (2002)

Apolipoprotein E (apoE), an apoprotein involved in lipid transport in both the plasma and within the brain, mediates the binding of lipoproteins to members of the low density lipoprotein (LDL) receptor family including the LDL receptor and the LDL receptor-related protein (LRP). ApoE/LRP interactions may be particularly important in brain where both are expressed at high levels, and polymorphisms in the apoE and LRP genes have been linked to AD. To date, only apoE-enriched lipoproteins have been shown to be LRP ligands. To investigate further whether other, more lipid-poor forms of apoE interact with LRP, we tested whether lipid-free apoE in the absence of lipoprotein particles interacts with its cell-surface receptors. No detectable lipid was found associated with bacterially expressed and purified apoE either prior to or following incubation with cells when analyzed by electrospray ionization mass spectrometry. We found that the degradation of lipid-poor (125)I-apoE was significantly higher in wild type as compared to LRP-deficient cells, and was inhibited by receptor-associated protein (RAP). In contrast, (125)I-apoE-enriched beta-VLDL was degraded by both LRP and the LDL receptor. When analyzed via a single cycle of endocytosis, (125)I-apoE was internalized prior to its subsequent intracellular degradation with kinetics typical of receptor-mediated endocytosis. Thus, we conclude that a very lipid-poor form of apoE can be catabolized via cell surface LRP, suggesting that the conformation of apoE necessary for recognition by LRP can be imposed by situations other than an apoE-enriched lipoprotein.
Effects of Gabapentin on Brain GABA, Homocarnosine, and Pyrrolidinone in Epilepsy Patients (2000)

GBP promptly elevates brain GABA and presumably offers partial protection against further seizures within hours of the first oral dose. Patients may expect to experience the anticonvulsant effects of increased homocarnosine and pyrrolidinone with daily therapy.