gebhart/patrepeval huggingface dataset:
Well-Defined High-Molecular-Weight Polyacrylonitrile via Activators Regenerated by Electron Transfer ATRP (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTWell-Defined High-Molecular-Weight Polyacrylonitrile via Activators Regenerated by Electron Transfer ATRPHongchen Dong, Wei Tang, and Krzysztof MatyjaszewskiView Author Information Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213 Cite this: Macromolecules 2007, 40, 9, 2974–2977Publication Date (Web):April 4, 2007Publication History Received16 February 2007Revised20 March 2007Published online4 April 2007Published inissue 1 May 2007https://pubs.acs.org/doi/10.1021/ma070424ehttps://doi.org/10.1021/ma070424erapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views3569Altmetric-Citations174LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Copper,Gel permeation chromatography,Physical and chemical properties,Radical polymerization Get e-Alerts
Propofol (2005)

Propofol is a potent lipophilic anesthetic that was initially formulated in Cremophor El for human use. Because of the occurrence of Cremophor EL anaphylaxis and improvements in the quality of lipid emulsions, it was ultimately brought to market as 1% propofol formulated in 10% soybean oil emulsion. Emulsions represent complex formulation compositions whose suitability for intravenous administration is dependent on a number of factors. Despite the success of propofol emulsions, drawbacks to such formulations include inherent emulsion instability, injection pain, a need for antimicrobial agents to prevent sepsis, and a concern of hyperlipidemia-related side effects. Efforts to overcome such drawbacks have involved the development of propofol emulsions with altered propofol and lipid contents, the addition of different excipients to emulsions for antimicrobial activity, and study of nonemulsion formulations including propofol-cyclodextrin and propofol-polymeric micelle formulations. In addition, a number of propofol prodrugs have been made and evaluated.
Regulation of gene expression : 25 years on (1986)

This volume describes the regulatory mechanisms which operate at the level of gene expression. The authors primarily discuss bacterial systems but some consideration is also given to lower eukaryotes. The early chapters of the book deal with regulation of gene expression in the context of cellular physiology. Subsequent chapters deal with the major new developments in our understanding of the molecular basis of the control of gene expression, namely: promoter/operator structure; DNA-protein interaction; control of mRNA turnover; positive regulation of gene expression; antisense RNA; DNA supercoiling; and transcription termination. The final two chapters consider specific problems in gene expression in Streptomycetes and in Dictyostelium.
Preclinical Evaluation of a High-Affinity 18F-Trifluoroborate Octreotate Derivative for Somatostatin Receptor Imaging (2014)

(18)F-AMBF3-TATE was radiolabeled in high yield and at high specific activity, did not require high-performance liquid chromatography purification, exhibited unexpectedly high binding affinity to somatostatin receptor subtype 2, and showed excellent pharmacokinetic properties in vivo, with high tumor uptake and high contrast ratios.
Characterization of serum β-glucuronyltransferase involved in chondroitin sulfate biosynthesis (1997)

We studied a glucuronyltransferase involved in chondroitin sulfate (CS) biosynthesis in a preparation obtained from fetal bovine serum by heparin-Sepharose affinity chromatography. This enzyme transferred GlcA from UDP-GlcA to the nonreducing GalNAc residues of polymeric chondroitin. It required Mn2+ for maximal activity and showed a sharp pH optimum between pH 5.5 and 6.0. The apparent Km value of the glucuronyltransferase for UDP-GlcA was 51 microM. The specificity was investigated using structurally defined acceptor substrates, which consisted of chemically synthesized tri-, penta-, and heptasaccharide-serines and various odd-numbered oligosaccharides with a GalNAc residue at the nonreducing terminus, prepared from chondroitin and CS by chondroitinase ABC digestion followed by mercuric acetate treatment. The enzyme utilized a heptasaccharide-serine GalNAc beta 1-4GlcA beta 1-3GalNAc beta 1-4GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl beta 1-O-Ser and a pentasaccharide-serine GalNAc beta 1-4GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl beta 1-O-Ser as acceptors. In contrast, neither a trisaccharide-serine Gal beta 1-3Gal beta 1-4Xyl beta 1-O-Ser nor an alpha-GalNAc-capped pentasaccharide-serine GalNAc alpha 1-4GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl beta 1-O-Ser that is a model compound of the reaction product formed by the action of the alpha-GalNAc transferase recently demonstrated in fetal bovine serum (Kitagawa et al., J. Biol. Chem., 270, 22190-22195, 1995) was utilized as an acceptor. Besides, all nonsulfated odd-numbered oligosaccharides except for the trisaccharide GalNAc beta 1-4GlcA beta 1-3GalNAc served as acceptors and the transfer rates roughly increased with increasing chain length. Moreover, 6-O-sulfation of nonreducing terminal GalNAc markedly enhanced GlcA transfer, whereas 4-O-sulfation had little effect on it. These results indicated that at least two glucuronyltransferases are involved in the biosynthesis of CS and that sulfation reactions may play important roles in chain elongation.
Jugular Venous Pulse: Window into the Right Heart (2007)

Although physicians began associating conspicuous neck veins with heart disease almost three centuries ago, the jugular venous pulse remains an often ignored component of the physical examination. Many physicians have not invested in the necessary understanding of the technique, and there is a misconception that its examination is difficult and of limited clinical value. When performed properly, evaluation of the jugular venous pulse can be extremely useful in distinguishing the cause of dyspnea and edema. The normal jugular venous pulse is reviewed, and pulse wave abnormalities are described, including ways in which they can provide clues to the diagnosis of certain disease states, ranging from pericardial disease to conduction disturbances. The jugular venous pulse provides a window into the right heart and an occasional glimpse of left heart hemodynamics. By peering through this window, clinicians can gain valuable information in the diagnostic evaluation of the cardiovascular patient.
OFDM Symbol Design for Peak-to-Average Power Ratio Reduction Employing Non-Data Bearing Subcarriers (2008)

In this paper, we present a novel peak-to-average power ratio (PAPR) reduction algorithm for OFDM systems employing a symbol balancing approach with several non-data bearing (NDB) subcarriers. The proposed algorithm assigns the NDB subcarriers values that, when combined with interleaving, reduces the long correlation patterns of the input frame that can potentially lead to high PAPR. Furthermore, the proposed algorithm can use either a fixed number of NDB subcarriers or a variable number of NDB subcarriers according to the amount of inter-subcarrier correlation, thus attempting to increase the data throughput of the system. Simulation results for a 256-subcarrier OFDM system employing QPSK symbols and 16 interleavers can achieve a PAPR reduction of 4 dB for a complementary cumulative distribution of 0.01%.
Effects of Elevated Sucrose-Phosphate Synthase Activity on Photosynthesis, Assimilate Partitioning, and Growth in Tomato (Lycopersicon esculentum var UC82B) (1993)

The expression of a sucrose-phosphate synthase (SPS) gene from maize (Zea mays, a monocotyledon) in tomato (Lycopersicon esculentum, a dicotyledon) resulted in marked increases in extractable SPS activity in the light and the dark. Diurnal modulation of the native tomato SPS activity was found. However, when the maize enzyme was present the tomato leaf cells were unable to regulate its activation state. No detrimental effects were observed and total dry matter production was unchanged. However, carbon allocation within the plants was modified such that in shoots it increased, whereas in roots it decreased. There was, therefore, a change in the shoot:root dry weight ratio favoring the shoot. This was positively correlated with increased SPS activity in leaves. SPS was a major determinant of the amount of starch in leaves as well as sucrose. There was a strong positive correlation between the ratio of sucrose to starch and SPS activity in leaves. Therefore, SPS activity is a major determinant of the partitioning of photosynthetically fixed carbon in the leaf and in the whole plant. The photosynthetic rate in air was not significantly increased as a result of elevated leaf SPS activity. However, the light- and CO2-saturated rate of photosynthesis was increased by about 20% in leaves expressing high SPS. In addition, the temporary enhancement of the photosynthetic rate following brief exposures to low light was increased in the high SPS plants relative to controls. We conclude that the level of SPS in the leaves plays a pivotal role in carbon partitioning. Furthermore, high SPS levels have the potential to boost photosynthetic rates under favorable conditions.
Epitomic analysis of appearance and shape (2003)

We present novel simple appearance and shape models that we call epitomes. The epitome of an image is its miniature, condensed version containing the essence of the textural and shape properties of the image. As opposed to previously used simple image models, such as templates or basis functions, the size of the epitome is considerably smaller than the size of the image or object it represents, but the epitome still contains most constitutive elements needed to reconstruct the image. A collection of images often shares an epitome, e.g., when images are a few consecutive frames from a video sequence, or when they are photographs of similar objects. A particular image in a collection is defined by its epitome and a smooth mapping from the epitome to the image pixels. When the epitomic representation is used within a hierarchical generative model, appropriate inference algorithms can be derived to extract the epitome from a single image or a collection of images and at the same time perform various inference tasks, such as image segmentation, motion estimation, object removal and super-resolution.
Studying the Use of Interactive Multilingual Information Retrieval (2006)

talk as if information retrieval were machines, but in reality the systems that we use to retrieve information are synergistic combinations of collections, machines, and processes that people use to search the collection(s) using the machine(s). Model-based evaluations such as those pioneered at Cranfield and now used in TREC, CLEF, and SIGIR focus on some functions of the machine (in particular, how best to build ranked lists). This paper expands that focus to examine what we have learned about the processes by which those machines will be used to perform Cross-Language Information Retrieval (CLIR), concluding with a brief description of how that perspective informs the nature of our research in DARPA's new GALE program.
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector (1996)

Muscle-directed gene transfer is being considered for the treatment of several metabolic diseases, including hemophilia and Duchene's muscular dystrophy. Previous efforts to target this tissue for somatic delivery with various vector systems have resulted in transient expression due to silencing of the transgene or to an immune response against the vector-transduced cells. We introduced recombinant adeno-associated virus vector (rAAV) carrying a lacZ reporter into muscle tissue of immunocompetent mice. The lacZ reporter gene was efficiently transduced and expressed with no evidence of a cellular immune response. Moreover, gene expression persisted for more than 1.5 years. Molecular characterization of rAAV vector DNA suggests a mechanism for persistence, since vector episomes convert to high-molecular-weight genomic DNA. These data provide the first report for establishing long-term gene transduction into mammalian muscle cells in vivo without the need for immune modulation of the organism.
Recombinant Newcastle Disease Virus Expressing a Foreign Viral Antigen Is Attenuated and Highly Immunogenic in Primates (2005)

Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the adult human population due to high seroprevalence, an effect that would reduce vector immunogenicity. To address this issue, we evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is serotypically distinct from common human pathogens, as a vaccine vector. Two strains were evaluated: the attenuated vaccine strain LaSota (NDV-LS) that replicates mostly in the chicken respiratory tract and the Beaudette C (NDV-BC) strain of intermediate virulence that produces mild systemic infection in chickens. A recombinant version of each virus was modified by the insertion, between the P and M genes, of a gene cassette encoding the human parainfluenza virus type 3 (HPIV3) hemagglutinin-neuraminidase (HN) protein, a test antigen with considerable historic data. The recombinant viruses were administered to African green monkeys (NDV-BC and NDV-LS) and rhesus monkeys (NDV-BC only) by combined intranasal and intratracheal routes at a dose of 10(6.5) PFU per site, with a second equivalent dose administered 28 days later. Little or no virus shedding was detected in nose-throat swabs or tracheal lavages following immunization with either strain. In a separate experiment, direct examination of lung tissue confirmed a highly attenuated, restricted pattern of replication by parental NDV-BC. The serum antibody response to the foreign HN protein induced by the first immunization with either NDV vector was somewhat less than that observed following a wild-type HPIV3 infection; however, the titer following the second dose exceeded that observed with HPIV3 infection, even though HPIV3 replicates much more efficiently than NDV in these animals. NDV appears to be a promising vector for the development of vaccines for humans; one application would be in controlling localized outbreaks of emerging pathogens.
Supervisory signal transmission methods for optical amplifier repeater systems (2002)

Supervisory (SV) signal transmission techniques are proposed for transmission systems with inline optical amplifiers. Several methods of sending an SV signal over the same fiber along with the line signal passes are examined. Transmission over 75 km along with a 1.8 Gb/s line signal is confirmed by modulating the pump light power of the optical amplifier (laser diode) with a 2 Mb/s bipolar signal, without degrading the line signal. The remaining pump light unabsorbed by the amplifying fiber carries the SV signal. Another method described is polarization modulation of line-signal light. A transmission experiment over a 1000 km fiber through 14 optical amplifiers confirms the applicability of polarization modulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Regulation of cyclin‐dependent kinase 5 and p53 by ERK1/2 pathway in the DNA damage‐induced neuronal death (2006)

DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA damage is controlled. Using mouse cortical neurons and SH-SY5Y human neuroblastoma cells, we identify a critical role of ERK signaling in neuronal death induced by DNA damage upon mitomycin C treatment. In addition, we provide evidence that the ERK signaling regulates Cyclin-dependent kinase 5 (Cdk5) activity and stability of tumor suppressor p53. Mitomycin C increased expression of p35, a specific activator of neuronal Cdk5 in an ERK1/2-dependent manner. Moreover, stability of p53 was increased by its phosphorylation on Ser33 and Ser46 by Cdk5, leading to neuronal death. Finally, we show that activated ERK induced increased expression of the Egr-1 transcription factor, which then bound to the promoter region of p35. We suggest subsequent increase of p35 expression and Cdk5 activity contribute to p53-dependent neuronal death. Thus, the present finding provides a new insight into a molecular mechanism underlying DNA damage-induced neuronal death.
Meeting Reports: Advanced Photon Source 14th User Meeting (2005)

The 2005 Advanced Photon Source (APS) User Meeting commemorated the tenth anniversary of first light at the APS. The weeklong meeting, with more than 600 participants, was held May 2–5, 2005, in collaboration with the new Center for Nanoscale Materials (CNM). The CNM, sited adjacent to the APS experiment hall, is currently under construction. Monday's session concentrated on CNM activities. Business and science sessions on Wednesday and Thursday morning highlighted the APS. Nine workshops related to CNM and APS science filled the schedule on Tuesday, Thursday afternoon, and Friday.
Viral RNA Mutations Are Region Specific and Increased by Ribavirin in a Full-Length Hepatitis C Virus Replication System (2002)

High rates of genetic variation ensure the survival of RNA viruses. Although this variation is thought to result from error-prone replication, RNA viruses must also maintain highly conserved genomic segments. A balance between conserved and variable viral elements is especially important in order for viruses to avoid "error catastrophe." Ribavirin has been shown to induce error catastrophe in other RNA viruses. We therefore used a novel hepatitis C virus (HCV) replication system to determine relative mutation frequencies in variable and conserved regions of the HCV genome, and we further evaluated these frequencies in response to ribavirin. We sequenced the 5' untranslated region (5' UTR) and the core, E2 HVR-1, NS5A, and NS5B regions of replicating HCV RNA isolated from cells transfected with a T7 polymerase-driven full-length HCV cDNA plasmid containing a cis-acting hepatitis delta virus ribozyme to control 3' cleavage. We found quasispecies in the E2 HVR-1 and NS5B regions of untreated replicating viral RNAs but not in conserved 5' UTR, core, or NS5A regions, demonstrating that important cis elements regulate mutation rates within specific viral segments. Neither T7-driven replication nor sequencing artifacts produced these nucleotide substitutions in control experiments. Ribavirin broadly increased error generation, especially in otherwise invariant regions, indicating that it acts as an HCV RNA mutagen in vivo. Similar results were obtained in hepatocyte-derived cell lines. These results demonstrate the potential utility of our system for the study of intrinsic factors regulating genetic variation in HCV. Our results further suggest that ribavirin acts clinically by promoting nonviable HCV RNA mutation rates. Finally, the latter result suggests that our replication model may be useful for identifying agents capable of driving replicating virus into error catastrophe.
NeuFlow: A runtime reconfigurable dataflow processor for vision (2011)

In this paper we present a scalable dataflow hardware architecture optimized for the computation of general-purpose vision algorithms - neuFlow - and a dataflow compiler - luaFlow - that transforms high-level flow-graph representations of these algorithms into machine code for neuFlow. This system was designed with the goal of providing real-time detection, categorization and localization of objects in complex scenes, while consuming 10 Watts when implemented on a Xilinx Virtex 6 FPGA platform, or about ten times less than a laptop computer, and producing speedups of up to 100 times in real-world applications. We present an application of the system on street scene analysis, segmenting 20 categories on 500 × 375 frames at 12 frames per second on our custom hardware neuFlow.
In Vitro and Ex Vivo Testing of Tenofovir Shows It Is Effective As an HIV-1 Microbicide (2010)

These studies provide a mechanism for pre-clinical prediction of safety and efficacy of formulated microbicides. Tenofovir was effective against HIV-1 infection in our algorithm. These data support the use of tenofovir for pre-exposure prophylaxis.
Improvement in heteroepitaxial film quality by a novel substrate patterning geometry (1992)

We describe a novel substrate patterning geometry which can reduce epilayer threading dislocation densities by up to two orders of magnitude in GexSi1−x/Si(100) (x∼0.15–0.20) het- eroepitaxial layers. The basic pattern consists of a two-dimensional array of ∼2 μm diameter oxide pillars which are separated from each other by varying pitch dimensions, and which are staggered slightly from their neighbors with respect to the in-plane 〈011〉 directions. This ensures that a misfit dislocation nucleating at any point within the epilayer must eventually propagate into one of the pillars, where the threading end will be terminated. Prospects for surface planarization and overgrowth of the pillars are discussed.
A Wireless, Passive Embedded Sensor for Real-Time Monitoring of Water Content in Civil Engineering Materials (2008)

A wireless, passive embedded sensor was applied for real-time monitoring of water content in civil engineering materials such as sands, subgrade soils, and concrete materials. The sensor, which comprised of a planar inductor-capacitor (LC) circuit, was embedded in test samples so that the internal water content of the samples could be remotely measured with a loop antenna by tracking the changes in the sensor's resonant frequency. Since the dielectric constant of water was much higher compared with that of the test samples, the presence of water in the samples increased the capacitance of the LC circuit (capacitance of the capacitor was proportional to the dielectric constant of the medium between its electrodes), thus decreasing the sensor's resonant frequency. Using the described sensor, a study was conducted to investigate the drying rate of sand samples of different grain sizes. A study was also conducted to measure the curing rate of a portland cement concrete slab during casting, and its drying rate after it has been soaked in water. The described sensor technology can be applied for long-term monitoring of localized water content inside soils and sands to understand the environmental health in these media. In addition, this sensor will be useful for monitoring water content within concrete supports and road pavements. The measurement of water content is important for civil engineering infrastructure since excess water may hasten their degradation.