gebhart/patrepeval huggingface dataset:
Stress effect and enhanced magnetoresistance inLa0.67Ca0.33MnO3−δfilms (1998)

The transport properties and magnetoresistive behavior of ferromagnetic ${\mathrm{La}}_{0.67}{\mathrm{Ca}}_{0.33}{\mathrm{MnO}}_{3\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$ films deposited on Si and ${\mathrm{CeO}}_{2}$ buffered Si substrates has been investigated. The introduction of a ${\mathrm{CeO}}_{2}$ buffer layer between ${\mathrm{La}}_{0.67}{\mathrm{Ca}}_{0.33}{\mathrm{MnO}}_{3\mathrm{\ensuremath{-}}\mathrm{\ensuremath{\delta}}}$ films and Si substrates revealed a marked effect in shifting the resistivity peak to low temperature and increasing the resistivity, in a similar way to that earlier observed in hydrostatic pressure studies. Enhanced magnetoresistance, with a $\ensuremath{\Delta}\ensuremath{\rho}/{\ensuremath{\rho}}_{0}$ ratio of 96% at 97 K in a magnetic field of 12 T, has been obtained in such film structures. The increase in magnetoresistance and decrease in the ferromagnetic transition temperature compared with unbuffered layers can be ascribed to a partial release in stress. The observed phenomena can be understood by the weakened ferromagnetic coupling and the decrease in transfer integral for electrical conduction between Mn ions as a result of an increase in the Mn-O bond length due to decreased tensile stress in the $a\ensuremath{-}b$ plane, which correspond qualitatively with Zener double exchange theory.
ATTACKS ON WIN32 - PART II (2000)

In 1998 several anti-virus companies introduced heuristic scanning for 32-bit Windows viruses. As a result the number of anti-heuristic viruses is on the rise. In my paper I will introduce infection methods with special attention to the anti-heuristic infection techniques. I will also provide results achieved by testing old Win32 viruses and worms on Windows 2000. This provides a better understanding of the impact of old Win32 viruses on Windows 2000 and vice versa. The current number of 32-bit Windows viruses is almost 400. We have reached the point when automatic replication, detection and repair for the simple Windows viruses is becoming mandatory. PE repair is becoming very difficult if not impossible. Unfortunately, we have seen examples of new binary virus variants that were the result of inexact PE repair. This is a valid scenario since several products use CRCs to identify Trojans and worms. When a networked worm gets infected and repaired the result can be an unknown Windows virus. In this section I will describe the inexact nature of PE file repair. Furthermore, I will introduce the common techniques used by 32-bit Windows email worms and find out the possibilities, if any, of detecting them more generically. In the last part of the presentation I would like to talk about possible new virus models we are likely to see in the near future.
Intranasal Nicotine for Postoperative Pain Treatment (2004)

Treatment with a single dose of nicotine immediately before emergence from anesthesia was associated with significantly lower reported pain scores during the first day after surgery. The decreased pain was associated with a reduction in morphine utilization and the analgesic effect of nicotine was not associated with hypertension or tachycardia.
Cascaded χ (2) wavelength converterin LiNbO 3 waveguides with counter-propagating beams (1999)

A wideband wavelength converter is presented which is based on a cascaded second-order nonlinearity in periodically-poled LiNbO3 waveguides pumped at 1.5 µm. The converter uses counter-propagating beams in order to improve conversion efficiency and pump rejection. An internal conversion efficiency of –10 dB and a conversion bandwidth of 68 nm have been obtained in a 4 cm long device.
Rehabbing under Traffic (1986)

Redecking the Golden Gate Bridge with a light weight orthotropic steel plate deck left the 49 year old monument 11,000 tons lighter, 2 feet wider, and ready to carry traffic for the next 100 years. By day, workers prepared for the night crew, which sawed out existing deck sections and placed the new prefabricated units. Sidewalk sections were also removed but were rebuilt and replaced. The work took 401 nights, and contractors were assessed heavy penalties for lingering beyond 5:30 a.m., when the closed lanes had to be reopened to full traffic. An OCEA Special Citation for outstanding achievement in infrastructure rehabilitation.
Evolution of water proton nuclear magnetic relaxation during milk coagulation and syneresis: Structural implications (1993)

[Departement_IRSTEA]EAA [TR1_IRSTEA]EAA4-SENSORAL, Mesures et contrôle rapide de la qualité alimentaire
Churg-Strauss syndrome presented as multiple intracerebral hemorrhage (1997)

Intracerebral hemorrhage is an uncommon sequel of Churg-Strauss syndrome. We describe a 27 y old Taiwanese male patient who was clinicopathologically diagnosed as Churg-Strauss syndrome. The patient experienced a sudden onset of blurring of vision and slowness of motion and speech. Magnetic resonance imaging of the brain revealed lobar hemorrhage on right parieto-occipital and left parietal areas. The cause of cerebral hemorrhage was probably due to poorly controlled high blood pressure and vasculitis. He received pulse therapy of methylprednisolone and cyclophosphamide followed by oral prednisolone. His neurological symptoms responded well to such a regimen. Cerebral hemorrhage is a major cause of morbidity and death in patients with Churg-Strauss syndrome. Uncontrolled high blood pressure may cause cerebral hemorrhage. Careful monitor of blood pressure is critical for the management of Churg-Strauss syndrome patients.
Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy (2008)

X-linked adrenoleukodystrophy (X-ALD) is a fatal neurodegenerative disorder, characterized by progressive cerebral demyelination cerebral childhood adrenoleukodystrophy (CCALD) or spinal cord neurodegeneration (adrenomyeloneuropathy, AMN), adrenal insufficiency and accumulation of very long-chain fatty acids (VLCFA) in tissues. The disease is caused by mutations in the ABCD1 gene, which encodes a peroxisomal transporter that plays a role in the import of VLCFA or VLCFA-CoA into peroxisomes. The Abcd1 knockout mice develop a spinal cord disease that mimics AMN in adult patients, with late onset at 20 months of age. The mechanisms underlying cerebral demyelination or axonal degeneration in spinal cord are unknown. Here, we present evidence by gas chromatography/mass spectrometry that malonaldehyde-lysine, a consequence of lipoxidative damage to proteins, accumulates in the spinal cord of Abcd1 knockout mice as early as 3.5 months of age. At 12 months, Abcd1- mice accumulate additional proteins modified by oxidative damage arising from metal-catalyzed oxidation and glycoxidation/lipoxidation. While we show that VLCFA excess activates enzymatic antioxidant defenses at the protein expression levels, both in neural tissue, in ex vivo organotypic spinal cord slices from Abcd1- mice, and in human ALD fibroblasts, we also demonstrate that the loss of Abcd1 gene function hampers oxidative stress homeostasis. We find that the alpha-tocopherol analog Trolox is able to reverse oxidative lesions in vitro, thus providing therapeutic hope. These results pave the way for the identification of therapeutic targets that could reverse the deregulated response to oxidative stress in X-ALD.
Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. (1994)

The purpose of this study was to investigate whether oral tolerance, defined as Ag-specific immunologic unresponsiveness after Ag feeding, could be induced in humans after prolonged Ag ingestion. Eight adult volunteers ingested a total dose of 0.5 g of keyhole limpet hemocyanin (KLH) followed by subcutaneous immunization with KLH. Eight controls received only the subcutaneous immunization. In the group fed KLH, there was a significant reduction in KLH-specific T cell proliferation (p = 0.04) and delayed skin test responses (p = 0.07) to KLH. KLH ingestion alone did not induce significant levels of Abs in either serum or secretions. However, after the subsequent subcutaneous immunization, the number of circulating IgG and IgM anti-KLH-producing cells, the titers of serum IgG, IgA, and IgM anti-KLH Abs, and the titers of IgA anti-KLH Abs in saliva and intestinal secretions were significantly greater in the KLH-fed group than in the nonfed group. We conclude that KLH feeding induced systemic T cell tolerance, but B cell priming, at both systemic and mucosal sites. These studies support the concept of using Ag feeding as a treatment for certain immune-mediated diseases.
Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV (2011)

Supplementary data are available at Bioinformatics online.
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease (2008)

<b>Background:</b> At cross-section, cognitively normal individuals (NL) with a maternal history of late-onset Alzheimer disease (AD) have reduced glucose metabolism (CMRglc) on FDG-PET in the same brain regions as patients with clinical AD as compared to those with a paternal and a negative family history (FH) of AD. This longitudinal FDG-PET study examines whether CMRglc reductions in NL subjects with a maternal history of AD are progressive. <b>Methods:</b> Seventy-five 50- to 82-year-old NL received 2-year follow-up clinical, neuropsychological, and FDG-PET examinations. These included 37 subjects with negative family history of AD (FH−), 9 with paternal (FHp), and 20 with maternal AD (FHm). Two subjects had parents with postmortem confirmed AD. Statistical parametric mapping was used to compare CMRglc across FH groups at baseline, follow-up, and longitudinally. <b>Results:</b> At both time points, the FH groups were comparable for demographic and neuropsychological characteristics. At baseline and at follow-up, FHm subjects showed CMRglc reductions in the parieto-temporal, posterior cingulate, and medial temporal cortices as compared to FH− and FHp (<i>p</i> &lt; 0.001). Longitudinally, FHm had significant CMRglc declines in these regions, which were significantly greater than those in FH− and FHp (<i>p</i> &lt; 0.05). <b>Conclusions:</b> A maternal history of Alzheimer disease (AD) predisposes normal individuals to progressive CMRglc reductions in AD-vulnerable brain regions, which may be related to a higher risk for developing AD.
Proteins Linked to a Protein Transduction Domain Efficiently Transduce Pancreatic Islets (2001)

The resounding success of a new immunosuppressive regimen known as the Edmonton protocol demonstrates that islet cell transplantation is becoming a therapeutic reality for diabetes. However, under the Edmonton protocol, a single donor does not provide enough islets to attain the insulin independence of a transplant recipient. This limitation is mainly caused by islet apoptosis triggered during isolation. In this study, we describe a highly efficient system of transiently transferring anti-apoptotic proteins into pancreatic islets, thus opening an exciting new therapeutic opportunity to improve the viability of transplantable islets. We fused beta-galactosidase to the 11-amino acid residues that constitute the protein transduction domain (PTD) of the HIV/TAT protein and transduced pancreatic islets ex vivo with this fusion protein in a dose-dependent manner with >80% efficiency. We observed that transduction of the anti-apoptotic proteins Bcl-X(L) and PEA-15 fused to TAT/PTD prevented apoptosis induced by tumor necrosis factor-alpha in a pancreatic beta-cell line, indicating that TAT/PTD anti-apoptotic proteins retained their biological activity. Finally, we demonstrated that TAT-fusion proteins did not affect the insulin secretion capability of islets, as determined by glucose static incubation and by reversion of hyperglycemia in diabetic immunodeficient mice.
Integral Channel Features (2009)

We study the performance of 'integral channel features' for image classification tasks, focusing in particular on pedestrian detection.The general idea behind integral channel features is that multiple registered image channels are computed using linear and non-linear transformations of the input image, and then features such as local sums, histograms, and Haar features and their various generalizations are efficiently computed using integral images.Such features have been used in recent literature for a variety of tasks -indeed, variations appear to have been invented independently multiple times.Although integral channel features have proven effective, little effort has been devoted to analyzing or optimizing the features themselves.In this work we present a unified view of the relevant work in this area and perform a detailed experimental evaluation.We demonstrate that when designed properly, integral channel features not only outperform other features including histogram of oriented gradient (HOG), they also (1) naturally integrate heterogeneous sources of information, (2) have few parameters and are insensitive to exact parameter settings, (3) allow for more accurate spatial localization during detection, and (4) result in fast detectors when coupled with cascade classifiers.
Adaptive shaping of femtosecond polarization profiles (2003)

We report the experimental implementation of femtosecond polarization pulse shaping within an adaptive learning loop. This technique makes it possible to optimally and automatically generate light fields in which intensity, momentary frequency, and light polarization (i.e., ellipticity and orientation) change as a function of time within a single femtosecond laser pulse. By use of second-harmonic generation as a feedback signal in an evolutionary algorithm, specific phase- and polarization-modulated laser pulses are generated. Material dispersion and time-dependent modulations of the polarization state can be compensated. These experiments demonstrate the feasibility of adaptive quantum control experiments with polarization-shaped femtosecond laser pulses.
Affinity purification of Trypanosoma brucei small nuclear ribonucleoproteins reveals common and specific protein components. (1991)

We have developed a procedure for the affinity purification of small nuclear ribonucleoproteins (snRNPs) of Trypanosoma brucei (U2 and U4/U6 snRNPs), which are essential for trans splicing. Each of these snRNPs can be specifically and efficiently selected from T. brucei extracts through biotinylated antisense 2'-O-methylated RNA oligonucleotides immobilized on streptavidin-agarose. Protein analysis revealed a set of five low molecular weight polypeptides common to the U2 and U4/U6 snRNPs and the spliced leader RNP. In addition, several U2 and U4/U6 snRNP-specific protein components were identified. Using monoclonal antibodies against human snRNP proteins, we could not detect any significant cross-reaction with the trypanosomal U2 snRNP proteins. Thus, the trypanosomal snRNPs exhibit principal differences from the higher eukaryotic snRNPs not only in their RNA but also in their protein components.
Attention-Deficit Hyperactivity Disorder and Substance Abuse: Relationships and Implications for Treatment (1995)

Attention-deficit hyperactivity disorder (ADHD) and substance-use disorders are related to each other in a variety of ways. Although within the child-psychiatry literature earlier investigations were inconsistent regarding such a link, recent prospective studies that followed hyperactive children and normal controls into adulthood have found that hyperactive adults with a history of ADHD are more likely than controls to have substance-use disorders. The substance-abuse literature is less consistent regarding the potential association between ADHD and substance abuse. However, recent studies suggest that persons with a substance-use disorder, and particularly those with a cocaine-use disorder, may be more likely than the general population to have a childhood history of ADHD. Some of the inconsistency regarding this association is due to differences in diagnostic criteria, type of assessments used, and reliability of information obtained. Each of the potential relationships that may exist between ADHD and substance abuse has treatment implications for the clinician. Pharmacological as well as nonpharmacological approaches deserve further investigation. Because pharmacotherapy is a central component in the treatment of childhood ADHD, clinicians designing a strategy to treat both a substance-use disorder and ADHD need to consider pharmacological interventions. At present, the literature on pharmacological treatment for childhood ADHD is extensive and that for adult ADHD is growing; information regarding the treatment of cocaine abuse and concomitant ADHD symptoms remains limited.
12-YEAR OUTCOMES FOLLOWING PERMANENT PROSTATE BRACHYTHERAPY IN PATIENTS WITH CLINICALLY LOCALIZED PROSTATE CANCER (2005)

PPB offers acceptable 12-year BFR in patients who present with clinically localized prostate cancer. Implant dosimetry continues as an important predictor for BFR, while the addition of adjuvant therapies such as hormones and external radiation are insignificant. In patients who experience biochemical failure it appears that PSA doubling time is an important predictor of survival.
RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions (2002)

RelA-associated inhibitor (RAI) is an inhibitor of nuclear factor kappaB (NF-kappaB) newly identified by yeast two-hybrid screen as an interacting protein of the p65 (RelA) subunit. In this study, we attempted to examine the effect of RAI on transcription and replication of human immunodeficiency virus type 1 (HIV-1). We found that RAI inhibited gene expression from the HIV-1 long terminal repeat (LTR) even at the basal level. Upon in vitro DNA-binding reactions, RAI could directly block the DNA-binding of p65 subunit of NF-kappaB but not that of the p50 subunit or AP1. We found that RAI could also inhibit the DNA-binding of Sp1 and thus inhibit the basal HIV-1 promoter activity. We further examined the effects of RAI on Sp1 and found that RAI colocalizes with Sp1 in the nucleus and interacts with Sp1 in vitro and in vivo. Moreover, we found that RAI efficiently blocked the HIV-1 replication when cotransfected with a full-length HIV-1 clone. These findings indicate that RAI acts as an efficient inhibitor of HIV-1 gene expression in which both NF-kappaB and Sp1 play major roles.
Transurethral Hyperthermia for Benign Prostatic Hyperplasia: Preliminary Clinical Results (1990)

A total of 21 patients with biopsy proved benign prostatic hyperplasia underwent treatment on a pilot protocol involving intracavitary transurethral radiating microwave (630 or 915 MHz.) antenna hyperthermia. Acute and subacute toxicity was mild and consisted primarily of bladder spasm (26% of the patients), hematuria (23%) and dysuria (9%), none of which significantly limited the achievement of desired temperatures during the treatment sessions. No chronic treatment-related morbidity or mortality was observed. Detailed thermal mapping, performed along the course of the prostatic urethra, recorded temperatures of 43C or more at greater than 75% of the loci. Highly significant increases in urine flow rate, decrease in post-void residual urine capacity and decrease in frequency of nocturia were observed. A marginally significant decrease in prostate volume was noted and, with a median followup of 12.5 months, only 3 patients have required subsequent prostatic resection. Transurethral hyperthermia represents a safe and promising outpatient approach to treatment of benign prostatic hyperplasia, particularly for patients who are not candidates for conventional surgical approaches because of medical or personal reasons. Further studies with the goal of optimizing the technique appear to be warranted, although long-term results would be best evaluated with prospective phase 3 trials.
Carbon Nanotube Gas and Vapor Sensors (2008)

Carbon nanotubes have aroused great interest since their discovery in 1991. Because of the vast potential of these materials, researchers from diverse disciplines have come together to further develop our understanding of the fundamental properties governing their electronic structure and susceptibility towards chemical reaction. Carbon nanotubes show extreme sensitivity towards changes in their local chemical environment that stems from the susceptibility of their electronic structure to interacting molecules. This chemical sensitivity has made them ideal candidates for incorporation into the design of chemical sensors. Towards this end, carbon nanotubes have made impressive strides in sensitivity and chemical selectivity to a diverse array of chemical species. Despite the lengthy list of accomplishments, several key challenges must be addressed before carbon nanotubes are capable of competing with state-of-the-art solid-state sensor materials. The development of carbon nanotube based sensors is still in its infancy, but continued progress may lead to their integration into commercially viable sensors of unrivalled sensitivity and vanishingly small dimensions.
Chromones. III. A Total Synthesis of Khellin1 (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromones. III. A Total Synthesis of Khellin1T. A. Geissman and T. G. HalsallCite this: J. Am. Chem. Soc. 1951, 73, 3, 1280–1284Publication Date (Print):March 1, 1951Publication History Published online1 May 2002Published inissue 1 March 1951https://pubs.acs.org/doi/10.1021/ja01147a121https://doi.org/10.1021/ja01147a121research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthetic protocol for diarylethenes through Suzuki–Miyaura coupling (2011)

The synthesis of a variety of diarylethenes through the Suzuki-Miyaura coupling reaction of 1,2-dichlorohexafluorocyclopentene with arylboronic acids and esters has been developed. Thiophenes with various substituents such as cyano and ester functionalities can be incorporated.
Effect of a single graded dose of terbutaline tablets in patients with chronic bronchitis and bronchoconstriction. A double-blind, placebo, cross-over study. (1978)

Terbutaline, a selective beta2-adrenergic receptor stimulator was given to 10 patients with chronic bronchitis. The effects of the drug were tested by measurements of forced expiratory volume in 1 sec (FEV1), peak expiratory flow rate (PEFR), heart rate, blood pressure and blood gas analysis. The measurements were performed before and 1, 2, 4, 5, and 6 h after oral administration of placebo, 2.5 mg, or 5.0 mg terbutaline. Terbutaline caused a significant dose-related increase in FEV1 and PEFR as compared with placebo. The maximal effects were found at the 4-h measurement and were still present at the measurements performed at 6 h. Heart rate, blood pressure and arterial oxygen tension (PaO2) were not significantly affected. Four patients experienced side effects as tremor and/or heart palpitations. It is concluded that orally administered terbutaline may be an important therapeutical agent in the treatment of chronic bronchitis.