gebhart/patrepeval huggingface dataset:
Middle-to-High Density Viscoelastic Surfactant Fracturing Fluids: Preparation and Application (2005)

The Sebei gas reservoir in Qinghai is characterized by formation pressure coefficient ～1.3,strong salt sensibility and critical salinity 8×10~4 mg/L.For use in this and similar reservoirs,a middle-to-high density,of 1.05—1.70 g/cm~3,VES fracturing fluid(FF) is developed.The principles of formation and breakdown of VESFF are presented.The density of VESFF is boosted in terms of salt water,for which a relationship between density and class and concentration of inorganic salts is presented.A surfactant,CFP-Ⅲ, is specially developed and used in amount of 15—40 g/L in basic formulations.For a VESFF of density 1.30 g/cm~3 and CFP-Ⅲ concentration 40 g/L,the properties are dipicted by following data: the rheologic behavior at 20℃ is of shearingthinning type;the viscosity does not change practically at 20—45℃,raises with raising temperature at 45—90℃ and drops down at 90℃,being of 52 mPa·s at 110℃ therefore this system of VESFFs can be used at temperatures up to 120℃;viscosity is reduced by 25% when shearing at 20℃ and 170 1/s over 1 hr and kept at this level at shearing further;with 0.5% multihydrocarbon treating agent added,the VESFF breaks down thoroughly to give a liquor as thin as salt water;a damage in range 6.08—11.14% is observed to reservoir core permeability.With this VESFF used in pilots on fracturing/sand control in 13 gas wells of Sebei reservoir,the daily gas production per well is increased by 75—180% without any sand production.The curves of technologic parameters of fracturing/sand control operation are given for one typical well.
Clinical manifestations of chronic granulocytic leukemia. (1995)

CGL is a highly specific disease that is defined by strict hematologic parameters that include a pathognomonic differential leukocyte count. Usually CGL is accompanied by the presence, in bone marrow cells, of the Ph chromosome, the first chromosomal anomaly to be regularly associated with a human neoplastic disease. CGL is predominantly a disease of the productive middle years of life, which maximizes its adverse impact on family life and family economics. The disease is of worldwide distribution and there is a slight male preponderance. The disease is characterized by an initial chronic phase when it behaves as a differentiated neoplasm and responds very well to simple, nonintensive therapy. After a variable interval, CGL undergoes metamorphosis to a refractory phase that responds poorly or sometimes not at all to therapy, even when this is intensive. At the stage of metamorphosis a great variety of clinical and hematologic pictures occur, and CGL may mimic a myeloproliferative disease, a myelodysplasia, a subacute leukemia, AML, or ALL. The old concept of an abrupt, explosive transition from the chronic phase to a so-called blastic crisis is incorrect: this rarely occurs and in most patients who are carefully followed, CGL is observed to undergo two or more stepwise evolutions, eg, from chronic phase to an accelerated myeloproliferative phase to a phase that resembles AML. Many patients with CGL conform to an established pattern of clinical features. There is a history of insidious symptoms of anemia and of splenomegaly. The physical signs are those of pallor and marked splenomegaly, while the hematologic findings are of moderate anemia, moderate thrombocytosis, and a marked granulocytic leukocytosis with a specific differential count. The radiologic findings are typically normal. Diagnostic difficulty seldom arises with this classic presentation. The patient who is detected at an early stage of CGL may lack the history, physical signs, and fully developed hematologic picture of CGL. Before the availability of cytogenetic studies, the diagnosis could only be established with confidence by observing the patient until the typical features of the disease emerged. Also considered are the less frequent but important atypical presentations of CGL. The symptoms and complaints, findings on examination, complications and hematologic findings may depart from the typical case in a bewildering variety of ways, so that the diagnosis may be difficult, indeed, CGL is generally not the initial diagnosis that is made. When the patient with CGL has received treatment, it is usual for he or she to become asymptomatic, with no abnormal physical signs.(ABSTRACT TRUNCATED AT 400 WORDS)
Influence of departures from complete thermodynamic equilibrium on transport coefficient values: application to an oxygen plasma (1994)

The main transport coefficients (thermal and electrical conductivities, viscosity) of an oxygen plasma at atmospheric pressure and at lower pressures are calculated by a classical formalism described by Hirchfelder et al, using a plasma composition obtained from a collisional radiative model which allows the authors to take into account the influence of the radiation escape. Results show that the viscosity is not affected by departures from complete thermodynamic equilibrium but that electrical and thermal conductivities are appreciably affected, which has an effect on energy balance equations.
Cell senescence and human aging: where's the link? (2000)

Normal human cells will not divide forever in culture. After a defined number of passages, every culture enters a viable non-dividing state termed senescence. This led to the proposal that the progressive accumulation of senescent cells contributes to (but does not exclusively cause) the aging process. Data now suggest that cell senescence, like apoptosis, occurs as an anti-cancer mechanism. In vivo, extremely low rates of division occur over very long periods of time. Thus, by the end of its lifespan, an organism has performed a surprisingly large amount of cell turnover. In a normal culture the fraction of senescent cells increases smoothly with proliferation in vitro. This process can be accurately modelled by the progressive loss of telomeric sequence (proposed as a counting mechanism for senescence). Telomere length is usually maintained by the enzyme telomerase (repressed in many human tissues). Re-introduction of telomerase prevents the onset of senescence. However, data suggest that a separate telomere-independent pathway exists. Evidence that this pathway is present in humans is now emerging.
Joint Source coding and Packet Marking for Video Transmission over DiServ Networks (2002)

We consider transmission of video for real-time display over a network offering differentiated services. In such a network, the probability of loss for each video packet is determined by the service class assigned to it. Using information about the error concealment strategy at the decoder and the QoS status of the network, we jointly consider the selection of source coding parameters and packet classification. A minimum cost approach is presented in which the goal is to minimize the cost to transmit a video sequence, while achieving a desired level of video quality, as measured by the expected distortion of the received video sequence. An approach for minimizing the distortion subject to a cost constraint is also discussed. A solution approach based on Lagrangian relaxation and deterministic dynamic programming is presented. Experimental results demonstrate the advantage of simultaneously adapting the source coding and prior-
Denatured Muscle as a Nerve Conduit: A Functional, Morphologic, and Electrophysiologic Evaluation (1994)

This experimental study evaluated denatured skeletal muscle and denatured epineural basement membrane tube as conduits to bridge defects in rat sciatic nerve. A 1-cm segment of sciatic nerve was resected in 48 rats. In Group I (control), the segment was discarded; in Group 2, the segment was reimplanted orthotopically; in Group 3, the defect was bridged by denatured (liquid nitrogen frozen and thawed) muscle; and in Group 4, the resected nerve segment was denatured as in Group 3, the axons removed, and the resulting epineural basement membrane tube used as a conduit. Functional assessment was carried out with the sciatic functional index (SFI). Histologic examination of the graft was made at 1.5, 2, 2.5, 3, and 6 months postoperatively. At 6 months, a Grass neurostimulator was used to determine the minimal voltage necessary to elicit ankle motion. Hind-foot ulceration and/or toe loss occurred in all groups, but less commonly in the rats with denatured muscle and denatured nerve conduits. Both Groups 3 and 4 achieved a macroscopic appearance of nerve at 45 days. However, the denatured conduits were longer and narrower than in standard nerve grafts. In the distal nerve, a mixture of axonal regeneration and degeneration was seen in Groups 2 to 4. By 6 months, the microscopic appearance of the nerve grafts, conduits, and distal nerves was that of normal nerve, with no differences between the groups. Active plantar flexion following electrical stimulation was observed in Groups 2 to 4 at 6 months.(ABSTRACT TRUNCATED AT 250 WORDS)
YIQ vector quantization in a new color palette architecture (1996)

Many CRT displays use color palettes to save highspeed frame buffer memory and to support many interactive, real-time graphics and imaging operations. Existing quantization algorithms for color palettes cluster colors as 3-D vectors in a color space. Thus, they fail to remove the statistical redundancy in the image space. This weakness prevents a more efficient use of frame buffer capacity. We propose a simple product vector quantization (VQ) technique for frame buffers that exploits redundancies in both image and color spaces. The new VQ technique can reduce the frame buffer use of a color image by half from the current algorithms with comparable image quality. The NTSC YIQ rather than RGB color space is used in our product VQ scheme. Consequently, we propose to modify the current architecture of the color palette to suit the proposed product VQ algorithm in the YIQ mode. The modified color palette is nearly ten times smaller than the current RGB palette and is more flexible. The improved space efficiency in both frame buffer and color palette is achieved while neither complicating the control or logic of the frame buffer architecture nor increasing computational complexity of color quantization.
New treatments in age‐related macular degeneration (2003)

Age-related macular degeneration (AMD) is the leading cause of legal blindness in individuals 50 years and older in the developed world. Choroidal neovascularization (CNV) in exudative AMD is responsible for the majority of severe vision loss. Until recently, laser photocoagulation was the only well-established and widely accepted treatment for CNV. However, it is beneficial only for a small subset of patients, has a high rate of CNV persistence and recurrence and results in iatrogenic, collateral damage to the overlying retina. These issues make it difficult to recommend in the case of subfoveal lesions. Consequently, numerous experimental therapeutic interventions are under investigation with the common objective of destroying the CNV but leaving the foveal neurosensory retina intact. Treatment modalities can be grouped into five major categories: photodynamic therapy; radiotherapy; transpupillary thermotherapy; anti-angiogenic and angiostatic agents; and surgical intervention. The present review aims to explain the rationale behind these new treatments, analyse the evidence for their safety and efficacy, determine their stage of development and indicate in which patients they are potentially useful.
An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3 (2008)

Dysregulation of protein synthesis has been implicated in oncogenesis through a mechanism whereby "weak" mRNAs encoding proteins involved in cell proliferation are strongly translated when the protein synthesis apparatus is activated. Previous work has determined that many cancer cells contain high levels of eIF3h, a protein subunit of translation initiation factor eIF3, and overexpression of eIF3h malignantly transforms immortal NIH-3T3 cells. This is a general feature of eIF3h, as high levels also affect translation, proliferation, and a number of malignant phenotypes of CHO-K1 and HeLa cells and, most significantly, of a primary prostate cell line. Furthermore, overexpressed eIF3h inhibits Myc-dependent induction of apoptosis of primary prostate cells. eIF3h appears to function through translation, as the initial appearance of overexpressed eIF3h in rapidly induced NIH-3T3 cells correlates tightly with the stimulation of protein synthesis and the generation of malignant phenotypes. This oncogenic potential of eIF3h is enhanced by phosphorylation at Ser(183). Finally, reduction of eIF3h levels in breast and prostate cancer cell lines by short interfering RNA methods reduces their rates of proliferation and anchorage-independent growth in soft agar. The results provide compelling evidence that high eIF3h levels directly stimulate protein synthesis, resulting in the establishment and maintenance of the malignant state in cells.
Treponema pallidum receptor binding proteins interact with fibronectin. (1983)

Analysis of plasma proteins avidly bound to T. pallidum surfaces revealed the ability of T. pallidum to acquire numerous host macromolecules. No acquisition was evident by the avirulent spirochete, T. phagedenis biotype Reiter. Western blotting technology using hyperimmune antifibronectin serum as a probe revealed the ability of virulent treponemes to avidly bind fibronectin from a complex medium such as plasma. The specificity of the tiplike adherence of motile T. pallidum to fibronectin-coated glass surfaces and to fibronectin on HEp-2 cells was reinforced by the observation that pretreatment of coverslips or cell monolayers with monospecific antiserum against fibronectin substantially reduced T. pallidum attachment. The stoichiometric binding of T. pallidum to fibronectin-coated coverslips and the inability of unlabeled or 35S-radiolabeled treponemes to interact with glass surfaces treated with other plasma proteins further established the specific nature of the interaction between virulent T. pallidum and fibronectin. The avid association between three outer envelope proteins of T. pallidum and fibronectin was also demonstrated. These treponemal surface proteins have been previously identified as putative receptor-binding proteins responsible for T. pallidum parasitism of host cells. The data suggest that surface fibronectin mediates tip-oriented attachment of T. pallidum to host cells via a receptor-ligand mechanism of recognition.
供你选择:FastTrack与Internet Information Server (1996)

即使你有足够的耐心等待数兆字节内容的下载,从而得到大量的软件,今天的Internet还是证明了古谚所说——没有免费的午餐。 让我们以Microsoft Internet Information Server Version 1.0(IIS)为例来看一看。此Web服务器软件可从Microsoft Web网点(http://
Two-level adaptive training branch prediction (1991)

Article Free Access Share on Two-level adaptive training branch prediction Authors: Tse-Yu Yeh Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, Michigan Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MichiganView Profile , Yale N. Patt Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, Michigan Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MichiganView Profile Authors Info & Claims MICRO 24: Proceedings of the 24th annual international symposium on MicroarchitectureSeptember 1991 Pages 51–61https://doi.org/10.1145/123465.123475Online:01 September 1991Publication History 483citation5,042DownloadsMetricsTotal Citations483Total Downloads5,042Last 12 Months372Last 6 weeks42 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Reconfigurable wide-band receiver with positive feed-back translational loop (2011)

A wide-band receiver for multi-band multi-standard cellular applications with a positive feed-back translational loop is presented in this paper. This technique allows tunable RF filtering right on the input node of the LNA with the base-band filter selectivity. The architecture is highly reconfigurable both regarding the RF channel center frequency and the channel bandwidth. The 65nm CMOS prototype circuit achieves, when in WCDMA mode, attenuation of out-of-band interferers of 12dB at 20MHz frequency offset, improving the out-of-band IIP3 by 17dB. The packaged test-chip provides good performance over a very wide frequency range from 1.3GHz to 2.85GHz.
Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats (2005)

Glucagon-like peptide-1(7-36)-amide (GLP-1) is postulated to act as a hormonal signal from gut to brain to inhibit food intake and gastric emptying. A mixed-nutrient meal produces a 2 to 3-h increase in plasma GLP-1. We determined the effects of intravenous infusions of GLP-1 on food intake, sham feeding, and gastric emptying in rats to assess whether GLP-1 inhibits food intake, in part, by slowing gastric emptying. A 3-h intravenous infusion of GLP-1 (0.5-170 pmol.kg(-1).min(-1)) at dark onset dose-dependently inhibited food intake in rats that were normally fed with a potency (mean effective dose) and efficacy (maximal % inhibition) of 23 pmol.kg(-1).min(-1) and 82%, respectively. Similar total doses of GLP-1 administered over a 15-min period were less potent and effective. In gastric emptying experiments, GLP-1 (1.7-50 pmol.kg(-1).min(-1)) dose-dependently inhibited gastric emptying of saline and ingested chow with potencies of 18 and 6 pmol.kg(-1).min(-1) and maximal inhibitions of 74 and 83%, respectively. In sham-feeding experiments, GLP-1 (5-50 pmol.kg(-1).min(-1)) dose-dependently reduced 15% aqueous sucrose intake in a similar manner when gastric cannulas were closed (real feeding) and open (sham feeding). These results demonstrate that intravenous infusions of GLP-1 dose-dependently inhibit food intake, sham feeding, and gastric emptying with a similar potency and efficacy. Thus GLP-1 may inhibit food intake in part by reducing gastric emptying, yet can also inhibit food intake independently of its action to reduce gastric emptying. It remains to be determined whether intravenous doses of GLP-1 that reproduce postprandial increases in plasma GLP-1 are sufficient to inhibit food intake and gastric emptying.
Dual-Functional, Receptor-Targeted Fluorogenic Probe for In Vivo Imaging of Extracellular Protease Expressions (2011)

Herein, we report a new type of in vivo fluorogenic probe that enables simultaneous and active targeting of overexpressed receptors, α(V)β(3) integrins, and extracellular proteases, matrix metalloproteinases (MMPs), in the tumor regions. This c(RGDyK)-conjugated MMP fluorogenic probe efficiently targets the tumor regions with high retention time while maintaining receptor binding affinity and substrate activity. The probe minimizes nonspecific accumulation, thus demonstrating improved tumor-to-background signal ratio (T/N) in both α(V)β(3) integrin- and MMP-overexpressing U87MG tumor-bearing mouse model. This strategy can be easily tuned for a wide array of applications targeting various receptors and extracellular proteases in vivo.
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway (2009)

Wnt ligands conduct their functions in canonical Wnt signaling by binding to two receptors, the single transmembrane low density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) and seven transmembrane (7TM) Frizzled receptors. Subsequently, phosphorylation of serine/threonine residues within five repeating signature PPPSP motifs on LRP6 is responsible for LRP6 activation. GSK3beta, a cytosolic kinase for phosphorylation of a downstream effector beta-catenin, was proposed to participate in such LRP6 phosphorylation. Here, we report a new class of membrane-associated kinases for LRP6 phosphorylation. We found that G protein-coupled receptor kinases 5 and 6 (GRK5/6), traditionally known to phosphorylate and desensitize 7TM G protein-coupled receptors, directly phosphorylate the PPPSP motifs on single transmembrane LRP6 and regulate Wnt/LRP6 signaling. GRK5/6-induced LRP6 activation is inhibited by the LRP6 antagonist Dickkopf. Depletion of GRK5 markedly reduces Wnt3A-stimulated LRP6 phosphorylation in cells. In zebrafish, functional knock-down of GRK5 results in reduced Wnt signaling, analogous to LRP6 knock-down, as assessed by decreased abundance of beta-catenin and lowered expression of the Wnt target genes cdx4, vent, and axin2. Expression of GRK5 rescues the diminished beta-catenin and axin2 response caused by GRK5 depletion. Thus, our findings identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.
The serologic response of patients with stage II melanoma to allogeneic melanoma cell vaccines (1985)

Seventeen patients with Stage II malignant melanoma were treated with vaccines prepared from three allogeneic melanoma cell lines in an attempt to induce a humoral immune response against melanoma cell surface antigens. The patients were free of detectable melanoma at the time of vaccination. Vaccines were prepared from three melanoma cell lines that expressed highly restricted melanocyte differentiation antigens. One of these cell lines also expressed an antigen found only on this particular line. The antigens were initially identified by antibodies in autologous serum; they were thus known to be recognized by the human immune system. In addition, two of the cell lines expressed HLA-A, -B, -C, and -DR antigens; no HLA antigens were detectable on the third line. The vaccines were administered sequentially by subcutaneous injection, mixed with bacillus Calmette-Guerin (BCG) or Corynebacterium parvum. The patients' sera were tested for antibodies against cell surface antigens of the vaccine cells in protein A assays and immune adherence assays, and the specificity of observed reactions was defined by absorption tests. Antibodies against alloantigens of the vaccine cells developed in 16 patients and in 15 patients, against antigens related to fetal calf serum in the culture medium. The magnitude of the antibody response to alloantigens varied considerably, with no difference between patients who received BCG or C. parvum with their vaccines. Antibodies against the restricted melanocyte differentiation antigens or the unique melanoma antigen expressed by the vaccine cells were not detected.