gebhart/patrepeval huggingface dataset:
POWER MODULATION FOR DIELECTRIC BARRIER-DISCHARGES (2005)

A dielectric barrier is a simple but efficient device to modulate the current in a gas dis- charge. The barrier-configuration, consisting of two electrodes, the dielectric barrier and the gas gap, is exposed to an alternating vol- tage. During the voltage rise pulse-like mi- crodischarges of short duration are generated in the gas gap. These microdischarges have different properties due to the voltage sup- plied at the electrodes. A high voltage pulse generator has been devel- oped to investigate the influence of voltage shape and pulse repetition rate on barrier- discharges. It is based on a semiconductor halfbridge with two IGBT-switches and a pulse- transformer for steep high voltage pulses. The amplitude and the repetition rate of the out- put pulses are adjustable. The maximum voltage is 17 kV, reached in 4 ps, the maximum repeti- tion rate is 30 kHz. The paper discusses the interaction between voltage generator and gas discharge. Charac- teristics of the power supply and barrier-dis- charge conditions, which are suitable for sur- face treatment applications, are pointed out.
Efficacy of injected liquid silicone in the diabetic foot to reduce risk factors for ulceration: a randomized double-blind placebo-controlled trial. (2000)

The results confirm the efficacy of plantar silicone injections in reducing recognized risk factors associated with diabetic foot ulceration.
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling (2010)

The genome of mantle cell lymphoma (MCL) is, in addition to the translocation t(11;14), characterized by a high number of secondary chromosomal gains and losses that probably account for the various survival times of MCL patients. We investigated 77 primary MCL tumors with available clinical information using high-resolution RNA expression and genomic profiling and applied our recently developed gene expression and dosage integrator algorithm to identify novel genes and pathways that may be of relevance for the pathobiology of MCL. We show that copy number neutral loss of heterozygosity is common in MCL and targets regions that are frequently affected by deletions. The molecular consequences of genomic copy number changes appear complex, even in genomic loci with identified tumor suppressors, such as the region 9p21 containing the CDKN2A locus. Moreover, the deregulation of novel genes, such as CUL4A, ING1, and MCPH1, may affect the 2 crucial pathogenetic mechanisms in MCL, the disturbance of the proliferation, and DNA damage response pathways. Deregulation of the Hippo pathway may have a pathogenetic role in MCL because decreased expression of its members MOBKL2A, MOBKL2B, and LATS2 was associated with inferior outcome, including an independent validation series of 32 MCLs.
Fabrication of coherent optical transversal filterconsisting of MMIsplitter/combiner and thermo-optic amplitude and phase controllers (1999)

The fabrication of an integrated-optic coherent transversal filter which is capable of synthesising almost arbitrary filter characteristics is reported. The transversal filter consists of a multimode interference (MMI) splitter for 1 × N signal splitting, delay arms with fixed path length difference, thermo-optic switches and phase shifters for arbitrarily weighting the signal and MMI N × 1 combiner to combine N tapped signals. Sinc-type and Gaussian-type spectral filter responses have been successfully realised showing good agreement with theoretical characteristics.
Inverse Kinematics Problem (IKP) of 6-DOF Manipulator by Locally Recurrent Neural Networks (LRNNs) (2010)

The paper presents a cognitive architecture for solution of inverse kinematics problem (IKP) of 6-DOF elbow manipulator with spherical wrist by Locally Recurrent Neural Networks (LRNNs) and simulated the solution by using MATLAB/Simulink. This design is aimed to allow the manipulator system to perform complex movement operations by solving the Inverse Kinematic Problem (IKP) with LRNNs by using the position and orientation of end-effector which represent by wrist with 3-DOF. The Levenberg-Marquardt back propagation (LMBP) is used in the learning of LRNNs which offered the high computation and accuracy for solving IKP for manipulator. This model permits direct forward dynamics simulation, which accurately predicts wrist position, also present a solution to the inverse problem of determining set of joints angle to achieve a given command for posture of manipulator. The simulation of design achieved by connect the program with Simulink\MATLAB Ver. 2009b to calculate the forward and inverse kinematic and implement the movements manipulator. Satisfactory results are obtained, that explains the ability of implement the posture of 6-DOF manipulator by calculate the kinematic with LRNNs and implement high complex movements.
The P2 Receptors in Platelet Function (2005)

After vessel wall injury, platelets adhere to the exposed subendothelium, are activated, and release mediators such as thromboxane A (2) (TXA (2)) and nucleotides stored at very high concentration in the so-called dense granules. Among other soluble agents, released nucleotides act in a positive feedback mechanism to cause further platelet activation and amplify platelet responses induced by agents such as thrombin or collagen. Adenine nucleotides act on platelets through three distinct P2 receptors: two are G protein-coupled adenosine diphosphate (ADP) receptors, namely the P2Y (1) and P2Y (12) receptor subtypes; the P2X (1) receptor ligand-gated cation channel is activated by adenosine triphosphate (ATP). The P2Y (1) receptor initiates platelet aggregation but is not sufficient for a full platelet aggregation in response to ADP, whereas the P2Y (12) receptor is responsible for completion of the aggregation to ADP. This receptor, the molecular target of the antithrombotic drug clopidogrel, is responsible for most of the potentiating effects of ADP when platelets are stimulated by agents such as thrombin, collagen, or immune complexes. The P2X (1) receptor is involved in platelet shape change and in activation by collagen under shear conditions. Each of these receptors is coupled to specific signal transduction pathways in response to ADP or ATP and is differentially involved in all of the sequential events involved in platelet function and hemostasis. As such, they represent potential targets for antithrombotic drugs.
Novel Polymeric Materials for Obtaining Blood-compatible Surfaces (1997)

Blood-compatible polymers are important for creating artificial organs and medical devices that can be applied clinically with efficiency and in safety. In this article, the molecular design of blood-compatible polymers is reviewed. In particular a novel concept for creating a biomembrane-mimicking surface on medical devices is summarized. Polymers with phospholipid polar groups that can construct a biomembrane-like surface suppress protein adsorption and subsequent platelet adhesion and activation. The application of these phospholipid polymers to modify surfaces can improve blood compatibility and lead to the development ofnew and useful medical devices.
Organically Modified Sol-Gel Sensors (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganically Modified Sol-Gel SensorsO. Lev, M. Tsionsky, L. Rabinovich, V. Glezer, S. Sampath, I. Pankratov, and J. GunCite this: Anal. Chem. 1995, 67, 1, 22A–30APublication Date (Print):January 1, 1995Publication History Published online4 June 2012Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/ac00097a711https://doi.org/10.1021/ac00097a711research-articleACS PublicationsRequest reuse permissionsArticle Views1371Altmetric-Citations325LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel agents for the treatment of pancreatic adenocarcinoma. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011. (2011)

There are urgent needs to develop novel and more effective regimens to improve outcomes of pancreatic cancer given its dismal prognosis and limited treatment options. Several phase I clinical trials involving novel agents were recently presented at the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting. It appears that hedgehog inhibition with IPI-926 was well-tolerated and might be effective in treating pancreatic cancer when combined with gemcitabine. The survival benefits will be tested in the following randomized phase II trial. The new combination of gemcitabine and blockade of checkpoint kinases with AZD7762 showed an acceptable safety profile. Furthermore, inhibition of PI3K by BAY80-6946 was well tolerated with PET-CT suggesting reduction in FDG uptake in some pancreatic cancer. The benefits of above novel agents/regimens need to be further tested in phase II trials.
Travelling waves for reaction-diffusion-convection systems (1998)

(1) ut = Auxx + f(u), u ∈ R , x ∈ R, t ∈ [0,∞), where A is a real, positive-definite, N × N matrix and f : R → R is a continuously differentiable nonlinear function. The vector u may represent, for example, the concentrations of chemicals or the population densities of interacting species, the interactions between components of u being modelled by the reaction term f(u) and their diffusion by Auxx. Travelling waves are solutions u of (1) in the form
Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma (2009)

The canine DLC1 is constructed highly similarly to the human gene, which has been shown to be an important tumor suppressor in many forms of cancer. As in human NHL, the promoter CpG island of DLC1 in canine NHL samples is abnormally hypermethylated, relative to normal lymphoid tissue. This study confirms that hypermethylation occurs in canine cancers, further supporting the use of companion dogs as comparative models of disease for evaluation of carcinogenesis, biomarker diagnosis, and therapy.
[Clinical observation and therapeutic mechanism of blocking agent of substance P nerves in the treatment of perennial allergic rhinitis]. (1995)

This paper reported the clinical effects and therapeutic mechanism of blocking agent of substance P(SP) nerves on prerennial allergic rhinitis. We applied capsaicin (CAP) in the treatment of 50 cases of perennial allergic rhinitis once a week and 4 times as a therapeutic course. By using highly specific and highly sensitive SP radioimmunoassay, the SP contents in nasal secretions were determined before and after CAP therapy. The results showed that clinical symptoms of allergic rhinitis were obviously relieved and SP content in the nasal secretions was remarkably reduced from 29.444 +/- 14.280pmol/L before CAP therapy to 16.848 +/- 10.622 pmol/L after therapy (P < 0.001). Of the 50 cases, 35 cases (70.0%) showed the best effects, 12 cases (24.0%) better effects and 3 cases (6.0%) no effects. The total effective rate was 94.0%. The study indicated that therapeutic mechanism of CAP on perennial allergic rhinitis is related to the reducing of SP and the blocking of axonal reflex of the SP nerves.
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review (2015)

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest mortality rates in most developed areas of the world. More than half of DLBLC patients can be cured with standard R-CHOP regimens, however approximately 30 to 40 % of patients will develop relapsed/refractory disease that remains a major cause of morbidity and mortality due to the limited therapeutic options.Recent advances in gene expression profiling have led to the identification of at least three distinct molecular subtypes of DLBCL: a germinal center B cell-like subtype, an activated B cell-like subtype, and a primary mediastinal B-cell lymphoma subtype. Moreover, recent findings have not only increased our understanding of the molecular basis of chemotherapy resistance but have also helped identify molecular subsets of DLBCL and rational targets for drug interventions that may allow for subtype/subset-specific molecularly targeted precision medicine and personalized combinations to both prevent and treat relapsed/refractory DLBCL. Novel agents such as lenalidomide, ibrutinib, bortezomib, CC-122, epratuzumab or pidilizumab used as single-agent or in combination with (rituximab-based) chemotherapy have already demonstrated promising activity in patients with relapsed/refractory DLBCL. Several novel potential drug targets have been recently identified such as the BET bromodomain protein (BRD)-4, phosphoribosyl-pyrophosphate synthetase (PRPS)-2, macrodomain-containing mono-ADP-ribosyltransferase (ARTD)-9 (also known as PARP9), deltex-3-like E3 ubiquitin ligase (DTX3L) (also known as BBAP), NF-kappaB inducing kinase (NIK) and transforming growth factor beta receptor (TGFβR).This review highlights the new insights into the molecular basis of relapsed/refractory DLBCL and summarizes the most promising drug targets and experimental treatments for relapsed/refractory DLBCL, including the use of novel agents such as lenalidomide, ibrutinib, bortezomib, pidilizumab, epratuzumab, brentuximab-vedotin or CAR T cells, dual inhibitors, as well as mechanism-based combinatorial experimental therapies. We also provide a comprehensive and updated list of current drugs, drug targets and preclinical and clinical experimental studies in DLBCL. A special focus is given on STAT1, ARTD9, DTX3L and ARTD8 (also known as PARP14) as novel potential drug targets in distinct molecular subsets of DLBCL.
Design and performance of a Ka-band monolithic phase shifter utilizing nonresonant FET switches (2000)

This paper describes design consideration and performance of a Ka-band monolithic phase shifter utilizing nonresonant FET switches. The switches show broad-band on/off characteristics up to 60 GHz without using inductors; thus, robust circuit design is possible for a switched-line phase shifter. To determine circuit topology, we introduce a schematic design approach. As a result, desired phase shift as well as good matching characteristics can be realized. The developed 4-bit monolithic phase shifter demonstrates an overall phase deviation less than 5/spl deg/ rms and an insertion loss variation less than 0.65 dB rms from 33 to 35 GHz. For all 16 states, the insertion loss is measured to be 13.1/spl plusmn/1.1 dB and the VSWR is less than 1.6. The chip size of the monolithic phase shifter is 2.5 mm/spl times/2.2 mm.
Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor. (1998)

IL-18 inhibits osteoclast (OCL) formation in vitro independent of IFN-gamma production, and this was abolished by the addition of neutralizing antibodies to GM-CSF. We now establish that IL-18 was unable to inhibit OCL formation in cocultures using GM-CSF-deficient mice (GM-CSF -/-). Reciprocal cocultures using either wild-type osteoblasts with GM-CSF -/- spleen cells or GM-CSF -/- osteoblasts with wild-type spleen cells were examined. Wild-type spleen cells were required to elicit a response to IL-18 indicating that cells of splenic origin were the IL-18 target. As T cells comprise a large proportion of the spleen cell population, the role of T cells in osteoclastogenesis was examined. Total T cells were removed and repleted in various combinations. Addition of wild-type T cells to a GM-CSF -/- coculture restored IL-18 inhibition of osteoclastogenesis. Major subsets of T cells, CD4+ and CD8+, were also individually depleted. Addition of either CD4+ or CD8+ wild-type T cells restored IL-18 action in a GM-CSF -/- background, while IL-18 was ineffective when either CD4+ or CD8+ GM-CSF -/- T cells were added to a wild-type coculture. These results highlight the involvement of T cells in IL-18-induced OCL inhibition and provide evidence for a new OCL inhibitory pathway whereby IL-18 inhibits OCL formation due to action upon T cells promoting the release of GM-CSF, which in turn acts upon OCL precursors.
Protein corona: implications for nanoparticle interactions with pulmonary cells (2017)

We show that different NPs variably adsorb proteins from the lung lining fluid. The amount of albumin in the NP corona varies as does NP uptake by AMs. However, albumin coating does not affect the translocation of gold NPs across the air-blood barrier. A more extensive database of corona composition of a diverse NP library will develop a platform to help predict the effects and biokinetics of inhaled NPs.
The selective enhancing influence of hemin and products of human erythrocytes on colony formation by human multipotential (CFUGEMM) and erythroid (BFUE) progenitor cells in vitro. (1983)

The influence of erythrocytes, extracts of erythrocytes and hemin was assessed on colony formation in vitro by human bone marrow multipotential (CFUGEMM), erythroid (BFUE) and granulocyte-macrophage (CFUGM) progenitor cells. Colony formation by CFUGEMM and BFUE present in the low density (less than 1.077 g/cm3) fraction of bone marrow cells was enhanced in the presence of high density (greater than 1.077 g/cm3) bone marrow cells. Erythrocytes, but not leukocytes, present in the high density fraction of cells were responsible for this enhancing effect on colony formation. Extracts of erythrocytes or hemin substituted for the enhancing activity of the intact erythrocytes. This enhancing activity was not apparent on colony formation by bone marrow CFUGM. These results demonstrate a selective enhancing influence on colonies derived from CFUGEMM and BFUE. Erythrocyte products allow the detection of such colonies and may play a role in the growth stimulation of CFUGEMM and BFUE.
The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurements (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurementsStephan Grzesiek and Ad BaxCite this: J. Am. Chem. Soc. 1993, 115, 26, 12593–12594Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00079a052https://doi.org/10.1021/ja00079a052research-articleACS PublicationsRequest reuse permissionsArticle Views1947Altmetric-Citations726LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of CD84 provides insight into SLAM family function (2007)

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. CD84 is a homophilic family member that enhances IFN-gamma secretion in activated T cells. Our solution studies revealed that CD84 strongly self-associates with a K(d) in the submicromolar range. These data, in combination with previous reports, demonstrate that the SLAM family homophilic affinities span at least three orders of magnitude and suggest that differences in the affinities may contribute to the distinct signaling behavior exhibited by the individual family members. The 2.0 A crystal structure of the human CD84 immunoglobulin variable domain revealed an orthogonal homophilic dimer with high similarity to the recently reported homophilic dimer of the SLAM family member NTB-A. Structural and chemical differences in the homophilic interfaces provide a mechanism to prevent the formation of undesired heterodimers among the SLAM family homophilic receptors. These structural data also suggest that, like NTB-A, all SLAM family homophilic dimers adopt a highly kinked organization spanning an end-to-end distance of approximately 140 A. This common molecular dimension provides an opportunity for all two-domain SLAM family receptors to colocalize within the immunological synapse and bridge the T cell and antigen-presenting cell.
Parenteral Nutrition-Associated Cholestasis in Preterm Neonates: Evaluation of Ursodeoxycholic Acid Treatment (1999)

Ursodeoxycholic acid treatment in premature infants appears to be safe, and leads to an early sustained decrease in bilirubin levels by two weeks of therapy. The response of transaminase levels was not sustained in our small cohort.
A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile (2000)

Ritter reaction of tertiary alcohols with chloroacetonitrile and subsequent cleavage of chloroacetyl group in the resulting chloroacetamide with thiourea is an efficient procedure for synthesis of tert-alkylamines.
Germ‐line transformation of the South American malaria vector, Anopheles albimanus , with a piggyBac / EGFP transposon vector is routine and highly efficient (2002)

Stable and efficient germ-line transformation was achieved in the South American malaria vector, Anopheles albimanus, using a piggyBac vector marked with an enhanced green fluorescent protein gene regulated by the Drosophila melanogaster polyubiquitin promoter. Transgenic mosquitoes were identified from four independent experiments at frequencies ranging from 20 to 43% per fertile G0. Fluorescence was observable throughout the body of larvae and pupae, and abdominal segments of adults. Transgenic lines analysed by Southern hybridization had one to six germ-line integrations, with most lines having three or more integrations. Hybridized transposon vector fragments and insertion site sequences were consistent with precise piggyBac-mediated integrations, although this was not verified for all lines. The piggyBac/PUbnlsEGFP vector appears to be a robust transformation system for this anopheline species, in contrast to the use of a piggyBac vector in An. gambiae. Further tests are needed to determine if differences in anopheline transformation efficiency are due to the marker systems or to organismal or cellular factors specific to the species.