gebhart/patrepeval huggingface dataset:
A New Channel Reservation and Prediction Concept in Cellular Communication Systems (1998)

In future wireless networks, the determination of the amount of resources that a base station (cell) must reserve to maintain a certain call dropping probability is likely to become a very important issue. We present in this paper a new algorithm for channel assignment in wireless networks called Predictive Reservation Policy (PRP) based on FCA concept. This new dynamic channel reservation scheme, adapts the number of guard channels in each cell to: 1) the current number of ongoing calls in neighbouring cells and 2) on the anticipation of the future localisation of users. The proposed scheme for radio channel allocation reduces handoff call blocking probability substantially at the expense of slight increases in new call blocking probability by giving resource access priority to handoff calls over new calls. PRP improves classical FCA and FCA with 2 or 3 reserved channel for Handoff exclusively.
Exploring the (1 ? 3)-?-D-glucan conformational phase diagrams to optimize the linear to macrocycle conversion of the triple-helical polysaccharide scleroglucan (1999)

The immunologically important (1 --> 6) comb-like branched (1 --> 3)-beta-D-glucans scleroglucan, schizophyllan, lentinan, and others, exist mainly as linear triple-helical structures in aqueous solution. Partial interconversion from linear to circular topology has been reported to take place following conformational transition of the triple-helical structure and subsequent regeneration of the triplex conformation. We here report on experimental data indicating that complete strand separation of the triple-helical structure is required for this interconversion. NaOH or dimethylsulfoxide was used to induce dissociation of the triplex at combinations of concentrations and temperatures shown by calorimetry to yield a conformational transition of the triplex structures. For the alkaline treatment at 55 degrees C, it is found that up to about 30% of the material readily can be converted to the cyclic topology. This fraction increased to about 60% when the subsequent annealing of the scleroglucan in aqueous solution at pH 7 was carried out at 100 degrees C. Further increase of the annealing temperature yielded a smaller relative amount of cyclic species. The data indicate that the lower molecular weight fraction of the molecular weight distributions can be converted selectively to the macrocyclic topology by conditions that do not yield complete strand separation of the whole sample. These findings add to previous reports by providing more details about how the conditions required for the linear triplex to macrocycle interconversion relate to the conformational properties of the triple-helical structure. Copyright 1999 John Wiley & Sons, Inc.
Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles (2005)

NR2A and NR2B are the predominant NR2 NMDA receptor subunits expressed in cortex and hippocampus. The relative expression level of NR2A and NR2B is regulated developmentally and these two subunits have been suggested to play distinct roles in long-term synaptic plasticity. We have used patch-clamp recording of recombinant NMDA receptors expressed in HEK293 cells to characterize the activation properties of both NR1/NR2A and NR1/NR2B receptors. Recordings from outside-out patches that contain a single active channel show that NR2A-containing receptors have a higher probability of opening at least once in response to a brief synaptic-like pulse of glutamate than NR2B-containing receptors (NR2A, 0.80; NR2B, 0.56), a higher peak open probability (NR2A, 0.50; NR2B, 0.12), and a higher open probability within an activation (NR2A, 0.67; NR2B, 0.37). Analysis of the sequence of single-channel open and closed intervals shows that both NR2A- and NR2B-containing receptors undergo multiple conformational changes prior to opening of the channel, with at least one of these steps being faster for NR2A than NR2B. These distinct properties produce profoundly different temporal signalling profiles for NR2A- and NR2B-containing receptors. Simulations of synaptic responses demonstrate that at low frequencies typically used to induce long-term depression (LTD; 1 Hz), NR1/NR2B makes a larger contribution to total charge transfer and therefore calcium influx than NR1/NR2A. However, under high-frequency tetanic stimulation (100 Hz; > 100 ms) typically used to induce long-term potentiation (LTP), the charge transfer mediated by NR1/NR2A considerably exceeds that of NR1/NR2B.
35-GHz Bandwidth, 5-V-cm Drive Voltage, Bulk GaAs Substrate Removed Electrooptic Modulators (2007)

Bulk GaAs-AlGaAs true push-pull electrooptic modulators with 5-V-cm V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">pi</sub> and 35-GHz bandwidth were demonstrated using substrate removal techniques. The traveling wave electrodes showed almost no dispersion, making it ideal for broadband applications.
IPSAT P1A, a class A beta-lactamase therapy for the prevention of penicillin-induced disruption to the intestinal microflora. (2009)

Ipsat Therapies Oy is developing IPSAT (intestinal protection system in antibiotic treatment) P1A, a class A beta-lactamase therapy that targets the penicillins to reduce the antibiotic concentration in the intestines, to prevent adverse effects on the normal enteric flora (eg, overgrowth of pathogenic bacteria and selection of antimicrobial resistance). In preclinical studies, IPSAT P1A, when administered with either ampicillin or piperacillin, inactivated these beta-lactam penicillin antibiotics in the jejunum of animals, with no effect on the mean serum ampicillin or piperacillin concentrations. Furthermore, IPSAT P1A demonstrated efficacy in phase IIb clinical trials by degrading ampicillin-antibiotic residues in the gastrointestinal tract of both healthy volunteers and hospitalized patients. At the time of publication, IPSAT P1A had completed a phase I trial in France, a phase IIb trial in Russia and Ukraine, and a phase IIa trial in Estonia. Based on the preliminary clinical data, the author concludes that IPSAT P1A is effective in humans, and the combination of this beta-lactamase with a beta-lactam antibiotic could potentially limit the overgrowth and selection of pathogens that colonize the intestinal tract.
CHAPTER I (2014)

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Impact of refactoring on quality code evaluation (2011)

Code smells are characteristics of the software that may indicate a code or design problem that can make software hard to understand, to evolve and maintain. Detecting code smells in the code and consequently applying the right refactoring steps, when necessary, is very important for improving the quality of the code. In this paper, according to well known metrics proposed to evaluate the code and design quality of a system, we analyze the impact of refactoring, applied to remove code smells, on the quality evaluation of the system.
The Anti-HIV Pseudopeptide HB-19 Forms a Complex with the Cell-surface-expressed Nucleolin Independent of Heparan Sulfate Proteoglycans (1999)

The HB-19 pseudopeptide 5[Kpsi(CH(2)N)PR]-TASP, psi(CH(2)N) for reduced peptide bond, is a specific inhibitor of human immunodeficiency virus (HIV) infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. Here, by using an experimental CD4(+) cell model to monitor HIV entry and infection, we demonstrate that HB-19 binds the cell surface and inhibits attachment of HIV particles to permissive cells. At concentrations that inhibit HIV attachment, HB-19 binds cells irreversibly, becomes complexed with the cell-surface-expressed nucleolin, and eventually results in its degradation. Accordingly, by confocal immunofluorescence microscopy, we demonstrate the drastic reduction of the cell-surface-expressed nucleolin following treatment of cells with HB-19. HIV particles can prevent the binding of HB-19 to cells and inhibit complex formation with nucleolin. Such a competition between viral particles and HB-19 is consistent with the implication of nucleolin in the process of HIV attachment to target cells. We show that another inhibitor of HIV infection, the fibroblast growth factor-2 (FGF-2) that uses cell-surface-expressed heparan sulfate proteoglycans as low affinity receptors, binds cells and blocks attachment of HIV to permissive cells. FGF-2 does not prevent the binding of HB-19 to cells and to nucleolin, and similarly HB-19 has no apparent effect on the binding of FGF-2 to the cell surface. The lack of competition between these two anti-HIV agents rules out the potential involvement of heparan sulfate proteoglycans in the mechanism of anti-HIV effect of HB-19, thus pointing out that nucleolin is its main target.
2,4-Dinitrobenzenesulfenyl as a Blocking Group for Hydroxyl Functions in Nucleosides1 (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT2,4-Dinitrobenzenesulfenyl as a Blocking Group for Hydroxyl Functions in Nucleosides1R. L. Letsinger, J. Fontaine, V. Mahadevan, D. A. Schexnayder, and R. E. LeoneCite this: J. Org. Chem. 1964, 29, 9, 2615–2618Publication Date (Print):September 1, 1964Publication History Published online1 May 2002Published inissue 1 September 1964https://pubs.acs.org/doi/10.1021/jo01032a032https://doi.org/10.1021/jo01032a032research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Patterns of Sex Steroid Hormones in Nipple Aspirate Fluid during the Menstrual Cycle and after Menopause in Relation to Serum Concentrations (2010)

Previous studies have shown that progesterone concentrations in serum and nipple aspirate fluid (NAF) are significantly correlated in premenopausal women, but estradiol concentrations are not. We therefore sought to ascertain the patterns of both steroids in NAF throughout the menstrual cycle and in postmenopausal women. Simultaneous samples of blood and NAF were obtained from 40 premenopausal and 16 postmenopausal women. Premenopausal samples were backdated from the following menstrual period. Steroids were purified by high-performance liquid chromatography before quantification by immunoassays. Serum steroids and NAF progesterone followed the expected pattern across the menstrual cycle, with a midcycle peak of estradiol and a midluteal peak of progesterone. However, the estradiol peak in NAF occurred about a week after the serum peak in the midluteal phase, when serum estradiol had declined to less than half the value at midcycle. NAF estrone was also elevated at the midluteal phase. Potential estrogen precursors androstenedione, estrone sulfate, and dehydroepiandrosterone sulfate declined in NAF from midcycle to the midluteal phase as NAF estradiol was increasing. Progesterone concentrations were significantly lower in NAF in postmenopausal women than in premenopausal women, but estrogen concentrations were not. This is the first description of the temporal relationships of sex steroids in NAF and serum relative to the menstrual cycle. These results provide insights into the lack of correlation of NAF and breast tissue estrogens with serum estrogens, and generate new hypotheses.
Radiation Therapy for Clinically Localized Prostate Cancer (1999)

Estimated PSA control rates in this pooled analysis are similar to those of single institutions. These rates indicate the probability of success for subsets of patients with tumors of several prognostic category groupings. These results represent a multi-institutional benchmark for evidence-based counseling of prostate cancer patients about radiation treatment.
15. Discogenic Low Back Pain (2010)

An estimated 40% of chronic lumbosacral spinal pain is attributed to the discus intervertebralis. Degenerative changes following loss of hydration of the nucleus pulposus lead to circumferential or radial tears within the annulus fibrosus. Annular tears within the outer annulus stimulate the ingrowth of blood vessels and accompanying nociceptors into the outer and occasionally inner annulus. Sensitization of these nociceptors by various inflammatory repair mechanisms may lead to chronic discogenic pain. The current criterion standard for diagnosing discogenic pain is pressure-controlled provocative discography using strict criteria and at least one negative control level. The strictness of criteria and the adherence to technical detail will allow an acceptable low false positive response rate. The most important determinants are the standardization of pressure stimulus by using a validated pressure monitoring device and avoiding overly high dynamic pressures by the slow injection rate of 0.05 mL/s. A positive discogram requires the reproduction of the patient's typical pain at an intensity of > 6/10 at a pressure of < 15 psi above opening pressure and at a volume less than 3.0 mL. Perhaps the most important and defendable response is the failure to confirm the discus is symptomatic by not meeting this strict criteria. Various interventional treatment strategies for chronic discogenic low back pain unresponsive to conservative care include reduction of inflammation, ablation of intradiscal nociceptors, lowering intranuclear pressure, removal of herniated nucleus, and radiofrequency ablation of the nociceptors. Unfortunately, most of these strategies do not meet the minimal criteria for a positive treatment advice. In particular, single-needle radiofrequency thermocoagulation of the discus is not recommended for patients with discogenic pain (2 B-). Interestingly, a little used procedure, radiofrequency ablation of the ramus communicans, does meet the (2 B+) level for endorsement. There is currently insufficient proof to recommend intradiscal electrothermal therapy (2 B±) and intradiscal biacuplasty (0). It is advised that ozone discolysis, nucleoplasty, and targeted disc decompression should only be performed as part of a study protocol. Future studies should include more strict inclusion criteria.
Uricase Inhibition in the Rat by s-Triazines: An Animal Model for Hyperuricemia and Hyperuricosuria (1969)

Oxonic acid and allantoxaidine were potent in vivo inhibitors of uricase. Oxonic acid, when fed to rats or injected intraperitoneally, produced a marked increase in blood plasma urate levels and urinary uric acid output with a concomitant decrease in urinary allantoin excretion. Addition of 5% oxonic acid plus 1% uric acid to the diet resulted in a 22-fold increase in urinary uric acid by day 23 of treatment with deposition of uric acid in the kidney tubules. The oxonic acid-treated rat may serve as a useful animal model for the study of hyperuricemia and hyperuricosuria.
Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ (2001)

The orphan nuclear receptor ERR beta is expressed in undifferentiated trophoblast stem cell lines and extraembryonic ectoderm, and genetic ablation of ERR beta results in abnormal trophoblast proliferation and precocious differentiation toward the giant cell lineage. Here, we show that the synthetic estrogen diethylstilbestrol (DES) promotes coactivator release from ERR beta and inhibits its transcriptional activity. Strikingly, treatment of trophoblast stem cells with DES led to their differentiation toward the polyploid giant cell lineage. In addition, DES-treated pregnant mice exhibited abnormal early placenta development associated with an overabundance of trophoblast giant cells and an absence of diploid trophoblast. These results define a novel pathway for DES action and provide evidence for steroidlike control of trophoblast development.
Multifunctional Aspects of the Action of Indole‐3‐Carbinol as an Antitumor Agent (1999)

Previous studies from this laboratory have suggested that 2-hydroxyestrone is protective against breast cancer, whereas the other principal metabolite, 16 alpha-hydroxyestrone, and the lesser metabolite quantitatively, 4-hydroxyestrone, are potent carcinogens. Attempts to directly decrease the formation of the 16-hydroxylated metabolite were either unsuccessful or required such high levels of the therapeutic agent as to be impractical. On the other hand the concentration of the protective metabolite, 2-hydroxyestrone, proved to be readily modulated by a variety of agents, both in the direction of increased protection and the opposite direction, increased risk by a variety of agents and activities. We have focussed our attention on indole-3-carbinol, a compound found in cruciferous vegetables, and its further metabolites in the body, diindolylmethane (DIM) and indolylcarbazole (ICZ), because of its relative safety and multifaceted activities. It has been shown that it induces CyP4501A1, increasing 2-hydroxylation of estrogens, leading to the protective 2-OHE1, and also decreases CyP1B1 sharply, inhibiting 4-hydroxylation of estradiol, thereby decreasing the formation of the carcinogenic 4-OHE1. In addition to these indirect effects as a result of altered estrogen metabolism, indole-3-carbinol has been shown to have direct effects on apoptosis and cyclin D, resulting in blockage of the cell cycle. In addition to its antitumor activity in animals, it has also been shown to be effective against HPV-mediated tumors in human patients. All of these responses make the study of its behavior as a therapeutic agent of considerable interest.
Insights into PARP Inhibitors’ Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays (2014)

PARP inhibitors are an exciting new class of antineoplastic drugs that have been proven to be efficacious as single agents in cancer settings with inherent DNA repair defects, as well as in combination with DNA-damaging chemotherapeutics. Currently, they are designed to target the catalytic domain of PARP-1, the most studied member of the family, with a key role in the DNA-damage repair process. Because PARP inhibitors are substrate (NAD(+)) competitors, there is a need for a deeper understanding of their cross-reactivity. This is particularly relevant for PARP-2, the PARP-1 closest homologue, for which an embryonic lethal phenotype has been observed in double knockout mice. In this study, we describe the development and validation of binding assays based on fluorescence polarization (FP) and surface plasmon resonance (SPR) techniques. PARP-1, PARP-2, PARP-3, and TNKS-1 FP displacement assays are set up by employing ad hoc synthesized probes. These assays are suitable for high-throughput screening (HTS) and selectivity profiling, thus allowing the identification of NAD(+)binding site selective inhibitors. The PARP-1 and PARP-2 complementary SPR binding assays confirm displacement data and the in-depth inhibitor characterization. Moreover, these formats have the potential to be broadly applicable to other members of the PARP family.
Dielectric properties of nanopowder emulsions in paraffin oil (2011)

This work investigates polarization phenomena induced by nanoparticle inclusions in paraffin oil, an insulating organic liquid. Fine metal oxide powders and nanopowders of Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , CuO, Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O and Fe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> were tested at concentrations up to 5% w/v in the liquid matrix. Emulsification was attained by ultrasound treatment. The relative dielectric constant and loss tangent (tand) of both pure oil and emulsions were recorded in the 20 Hz-1 MHz frequency range. Results depend both on grain size and on the specific compound. In the case of alumina nanoparticles, dielectric behavior is dominated by grain surface polarization phenomena induced by adsorbed water. This effect can be partially cancelled out by the addition of titania nanoparticles. Titanium and (to a lesser extent) ferric oxide increased the dielectric constant at middle and high frequencies. Copper (I) and (II) oxides exhibit a distinct relaxation mechanism at the high end of the frequency range.
Rock removal using high-power lasers for petroleum exploitation purposes (2002)

This paper describes the experimental results of selective rock removal using different types of high power lasers. US military owned continuous wave laser systems such as MIRACL and COIL with maximum powers of 1.2 MW and 10 kW and wavelengths of 3.8 and 1.3 mm respectively, were first used on a series of rock types to demonstrate their capabilities as a drilling tool for petroleum exploitation purposes. It was found that the power deposited by such lasers was enough to drill at speeds much faster than conventional drilling. In order to sample the response of the rocks to the laser action at shorter wavelengths, another set of rock samples was exposed to the interaction of the more commercially available high power pulsed Nd:YAG laser. To isolate the effects of the laser discharge properties on the rock removal efficiency, a versatile 1.6 kW Nd:YAG laser capable of providing pulses between 0.1 millisec and 10 millisec in width, with a maximum peak power of 32 kW and a variable repetition rate between 25 and 800 pulses/sec was chosen. With this choice of parameters, rock vaporization and melting were emphasized while at the same time minimizing the effects of plasma shielding. Measurements were performed on samples of sandstone, shale, and limestone. It was found that each rock type requires a specific set of laser parameters to minimize the average laser energy required to remove a unit volume of rock. It was also found that the melted material is significantly reduced in water saturated rocks while the drilling speed is still kept higher than conventional drilling.
Preparation and characterization of monodispersed metal hydrous oxide sols (2007)

The methods for preparation of colloidal dispersions of metal hydrous oxides consisting of particles exceedingly uniform in size and shape are described in detail. These sols are, as a rule, prepared by aging acidic solutions of metal salts at elevated temperatures. It is shown that the anions play a decisive role in the particle formation. Electron micrographs of such systems, as obtained from solutions of aluminum, chromium, thorium, titanium, iron, and copper salts, will illustrate that certain metal hydrous oxides appear in the form of spherical (amorphous) particles while others give well defined crystalline particles of different shapes. Certain properties and applications of these new inorganic latices are illustrated and discussed.