gebhart/patrepeval huggingface dataset:
Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group. (1992)

The extracellular domain of tumour necrosis factor-alpha (TNF-alpha) receptors have inhibitory properties against TNF-alpha. The relative ratio between ligand and ligand inhibitors may influence the outcome of meningococcaemia. To test this hypothesis, levels of TNF-alpha and of each of the soluble inhibitory fragments originating from two distinct TNF-alpha receptors (sTNF-RI and sTNF-RII) were measured in sera of children with severe meningococcaemia. On admission to the hospital the levels of sTNF-RI, -RII and TNF-alpha were markedly increased and all three correlated with the outcome of the disease. A correlation was found between TNF-alpha and sTNF-RI (P less than 0.001 by Pearson rank correlation coefficient) or sTNF-RII (P = 0.012). For TNF-alpha concentrations below 500 pg/ml, the increase of TNF-alpha was proportional to that of sTNF-RI and RII; however, when TNF-alpha levels exceeded 500 pg/ml, sTNF-RI and RII concentrations did not increase proportionally. At admission, in patients with fatal outcome, the ratios TNF-alpha/sTNF-RI and -RII were higher than in survivors. During the first 6 hr, the kinetics of TNF-alpha, sTNF-RI and -RII were different. Naturally occurring TNF-alpha inhibitors may play an important role in modulating the biological activity of TNF-alpha in severe meningococcaemia.
Site-selective cyclometalation of a metal–organic framework (2012)

Although porous materials, including metal–organic frameworks (MOFs), can be functionalized using heterogeneous reactions (solution–solid, gas–solid), there are no reports that modify chemically identical sites in a spatially selective, periodic fashion. Herein, the cyclometalation of two non-interpenetrated MOFs and an interpenetrated MOF in the solid state is reported using [Ir(COD)(OCH3)]2 and [Rh(COD)(Cl)]2 (COD = 1,5-cyclooctadiene). Incredibly, the cyclometalation of the interpenetrated MOF occurs only on ligands that lie along, one crystallographic axis, providing an unprecedented example of site-selective postsynthetic modification (PSM). This represents a degree of control on the functionalization of a porous, material that has not been otherwise realized, and is achieved in part because of the crystalline, periodic nature of MOFs. Furthermore, it was found that the degree of cyclometalation, increases the sorption capacity of the interpenetrated MOF.
Reversal of Dopamine D2Receptor Responses by an Anandamide Transport Inhibitor (2000)

We characterized the pharmacological properties of the anandamide transport inhibitor N-(4-hydroxyphenyl)-arachidonamide (AM404) in rats and investigated the effects of this drug on behavioral responses associated with activation of dopamine D(2) family receptors. Rat brain slices accumulated [(3)H]anandamide via a high-affinity transport mechanism that was blocked by AM404. When administered alone in vivo, AM404 caused a mild and slow-developing hypokinesia that was significant 60 min after intracerebroventricular injection of the drug and was reversed by the CB1 cannabinoid receptor antagonist SR141716A. AM404 produced no significant catalepsy or analgesia, two typical effects of direct-acting cannabinoid agonists. However, AM404 prevented the stereotypic yawning produced by systemic administration of a low dose of apomorphine, an effect that was dose-dependent and blocked by SR141716A. Furthermore, AM404 reduced the stimulation of motor behaviors elicited by the selective D(2) family receptor agonist quinpirole. Finally, AM404 reduced hyperactivity in juvenile spontaneously hypertensive rats, a putative model of attention deficit hyperactivity disorder. The results support a primary role of the endocannabinoid system in the regulation of psychomotor activity and point to anandamide transport as a potential target for neuropsychiatric medicines.
Total Syntheses of the Proposed Structure for Ieodoglucomides A and B (2013)

The first enantioselective total synthesis of new glycolipopeptides, ieodoglucomides A and B, has been accomplished along with synthetic elaboration to their C14-epimers starting from d-glucose using β-glycosylation and Grubbs olefin cross-metathesis reactions as the key steps. The present synthetic study has indicated the ambiguity in proposed absolute stereochemistry for the natural product.
Representing medical knowledge: reconciling the present or creating the future? (1992)

Modern technology has sparked the creation of computing systems that perform many medically related tasks, but communication between these systems is limited, in part by differences in the terminology used for various purposes and in part by the changing nature of medical concepts. The Unified Medical Language System represents an attempt to find a means of translation between diverse knowledge systems. An alternative, which we propose, is to agree on a knowledge base for the future and make use of present accomplishments in moving toward that goal.
An experimental 256-Mb DRAM with boosted sense-ground scheme (1994)

In developing the 256-Mb DRAM, the data retention characteristics must inevitably be improved. In order for DRAM's to remain the semiconductor device with the largest production volume in the 256-Mb era, we must develop a cost effective device with a small chip size and a large process tolerance. In this paper, we propose the BSG (boosted sense-ground) scheme for data retention and FOGOS (folded global and open segment bit-line) structure for chip size reduction. We have fabricated an experimental 256-Mb DRAM with these technologies and obtained a chip size of 304 mm/sup 2/ and a performance of 34 ns access time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Growth and characterization of low temperature silicon selective epitaxy (1990)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1990.
Ferric Carboxymaltose to Treat Isovolemic Anemia (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Exploitation of Nucleic Acid Packaging Signals To Generate a Novel Influenza Virus-Based Vector Stably Expressing Two Foreign Genes (2003)

At the final step in viral replication, the viral genome must be incorporated into progeny virions, yet the genomic regions required for this process are largely unknown in RNA viruses, including influenza virus. Recently, it was reported that both ends of the neuraminidase (NA) coding region are critically important for incorporation of this vRNA segment into influenza virions (Y. Fujii, H. Goto, T. Watanabe, T. Yoshida, and Y. Kawaoka, Proc. Natl. Acad. Sci. USA 100:2002-2007, 2003). To determine the signals in the hemagglutinin (HA) vRNA required for its virion incorporation, we made a series of deletion constructs of this segment. Subsequent analysis showed that 9 nucleotides at the 3' end of the coding region and 80 nucleotides at the 5' end are sufficient for efficient virion incorporation of the HA vRNA. The utility of this information for stable expression of foreign genes in influenza viruses was assessed by generating a virus whose HA and NA vRNA coding regions were replaced with those of vesicular stomatitis virus glycoprotein (VSVG) and green fluorescent protein (GFP), respectively, while retaining virion incorporation signals for these segments. Despite the lack of HA and NA proteins, the resultant virus, which possessed only VSVG on the virion surface, was viable and produced GFP-expressing plaques in cells even after repeated passages, demonstrating that two foreign genes can be incorporated and maintained stably in influenza A virus. These findings could serve as a model for the construction of influenza A viruses designed to express and/or deliver foreign genes.
Inactivation by Substrate plus Oxygen of the Pyruvate Dehydrogenase of a Strictly Anaerobic Bacterium (1965)

Research Article| March 01 1965 Inactivation by Substrate plus Oxygen of the Pyruvate Dehydrogenase of a Strictly Anaerobic Bacterium J. L. Peel; J. L. Peel Search for other works by this author on: This Site PubMed Google Scholar R. J. Watkinson R. J. Watkinson Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1965) 94 (3): 21C–24C. https://doi.org/10.1042/bj0940021C Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation J. L. Peel, R. J. Watkinson; Inactivation by Substrate plus Oxygen of the Pyruvate Dehydrogenase of a Strictly Anaerobic Bacterium. Biochem J 1 March 1965; 94 (3): 21C–24C. doi: https://doi.org/10.1042/bj0940021C Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1965 The Biochemical Society1965 Article PDF first page preview Close Modal You do not currently have access to this content.
Bit-Rate Reduction in the Transmission of High-Definition Television Signals (1987)

This article describes the bit-rate reduction of high-definition television (HDTV) signals. A fiber-optic HDTV 400-Mbit/sec digital transmission system has been developed with the use of time compression multiplexing (TCM), Nyquist sampling, and linear pulse code modulation (PCM) coding technologies. The target of this study is a bit-rate reduction to one-fourth the original data rate for HDTV signals. This system is applied to both an analog transmission and a digital transmission, with a bit rate of approximately 100 Mbits/sec. The simulation of HDTV bit-rate reduction shows that a combination of TCM, subsampling, and intraframe digital pulse code modulation (DPCM) technologies efficiently reduces HDTV transmission bit-rate to less than one-fourth.
Living the Thai Life—A Case Study of Volunteer Tourism at the Gibbon Rehabilitation Project, Thailand (2003)

Despite the growth of the volunteer tourism market, and the coverage afforded by the popular press, volunteer tourism has received little academic attention. This paper is based on an ethnographic case study of volunteering at the Gibbon Rehabilitation Project (GRP) in Thailand. The study explored the relationship between volunteers, their volunteering experiences and the outcomes that eventuated. The study findings revealed that volunteers were provided with substantial opportunities to make positive contributions to wildlife conservation. However, the findings also demonstrated that the volunteering experience was much more than just the work duties carried out at the project. Volunteers also engaged in local village life and undertook tourist activities, and the current paper focuses on these aspects of the volunteering experience. Living in shared accommodation at the project headquarters, in a small village on the island of Phuket, volunteers' free time was spent socialising and sightseeing with other volunteers and local Thais. Thus, volunteers were able to go beyond the superficial interactions that travel is often restricted to. Indeed, many volunteers discussed how living in this way enabled them to become immersed in the Thai culture and the way of life. These experiences contributed to ‘personal growth’ and a ‘changed view of the world’ being frequently identified benefits of volunteering.
Patterns of failure in small cell carcinoma of the lung (1982)

The initial sites and frequencies of disease progression in 97 patients with small cell carcinoma of the lung treated in a Northern California Oncology protocol were analyzed. Among the extensive disease complete responders (25 patients), the chest was the most frequent initial relapse site (18 patients), followed by the liver (nine patients) and bone (six patients). For those patients who had a partial or no response to treatment, the chest was the most frequent site of persistent disease and the majority progressed in the chest initially. The addition of chest irradiation (5000 rad/5 weeks) to patients with limited disease significantly reduced the incidence of relapse (25%) and prolonged the disease-free interval in the chest in the complete responders, but did not affect the failure pattern in partial and nonresponders. All patients received prophylactic cranial irradiation and three limited disease patients (10%) and three extensive disease patients (4%) progressed in the brain.
Quasi-Cyclic Low-Density Parity-Check Codes From Circulant Permutation Matrices (2004)

In this correspondence, the construction of low-density parity-check (LDPC) codes from circulant permutation matrices is investigated. It is shown that such codes cannot have a Tanner graph representation with girth larger than 12, and a relatively mild necessary and sufficient condition for the code to have a girth of 6, 8,10, or 12 is derived. These results suggest that families of LDPC codes with such girth values are relatively easy to obtain and, consequently, additional parameters such as the minimum distance or the number of redundant check sums should be considered. To this end, a necessary condition for the codes investigated to reach their maximum possible minimum Hamming distance is proposed.
A New Method to Model the Ionosphere Across Local Area Networks (2005)

In addition to an overall quasi-periodic 24 hour cycle, the ionosphere features many irregular disturbances. The detailed structure and dynamical evolution of the ionosphere continues to be one of the largest unpredictable factors in GNSS measurements. Across local area networks, however, the total electron content on the line of sight between the stations of a network and a given satellite is highly correlated between the stations due to the proximity of the signal rays as they propagate through the ionosphere. In this paper we consider local area networks of 4 to 50 stations with baselines of the order of 10 to 100 kilometers. Across these networks, we characterize the ionosphere around the piercing points in terms of the average total electron content and spatial corrections to first and higher order. To estimate the state of the ionosphere and integer ambiguities of the individual stations we process the phase measurements of the stations by means of a Kalman filter. Together with the code information and a tropospheric model for a full network solution (such as GPSNet, see Vollath et al. 2000, Vollath 2004) for reference station networks for RTK positioning, our novel approach leads to improved fixing results even during geomagnetic disturbances and for elevation angles as low as 10°. The validity of this technique is demonstrated for various networks around the globe. We find that the model correctly reproduces the expected ionospheric characteristics for all regions. While providing improved ambiguity fixing performance and reliability, the model also gives a physical description of the ionosphere throughout the day.
Enteropathogenic Escherichia coli (EPEC) – a crafty subversive little bug (2002)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Initiation of Bidirectional Replication at the Chromosomal Origin Is Directed by the Interaction between Helicase and Primase (1999)

Several protein-protein interactions have been shown to be critical for proper replication fork function in Escherichia coli. These include interactions between the polymerase and the helicase, the helicase and the primase, and the primase and the polymerase. We have studied the influence of these interactions on proper initiation at oriC by using mutant primases defective in their interaction with the helicase and DNA polymerase III holoenzyme lacking the tau subunit so that it will not interact with the helicase. We show here that accurate initiation of bidirectional DNA replication from oriC is dependent on proper placement of the primers for leading strand synthesis and is thus governed primarily by the interaction between the helicase and primase.
Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis. (1992)

These observations further confirm the essential role of PAI-1 in the regulation of the thrombolytic system and support the exploration of adjunctive therapy based on inhibition of PAI-1 activity in thrombolytic strategies.
Discrete fast algorithms for two-dimensional linear prediction on a polar raster (1992)

New generalized split Levinson and Schur algorithms for the two-dimensional linear least squares prediction problem on a polar raster are derived. The algorithms compute the prediction filter for estimating a random field at the edge of a disk from noisy observations inside the disk. The covariance function of the random field is assumed to have a Toeplitz-plus-Hankel structure for both its radial part and its transverse (angular) part. This assumption is valid for some types of random fields, such as isotropic random fields. The algorithms generalize the split Levinson and Schur algorithms in two ways: (1) to two dimensions; and (2) to Toeplitz-plus-Hankel covariances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effects of icodextrin in automated peritoneal dialysis on blood pressure and bioelectrical impedance analysis (2000)

Use of icodextrin for the daytime dwell in APD results in improved fluid balance and blood pressure control compared with 2.27% glucose. MFBIA detected clinically important changes in fluid content in these patients.
HyperSlides (2013)

Presentations are a crucial form of modern communication, yet there is a dissonance between everyday practices with presentation tools and best practices from the presentation literature. We conducted a grounded theory study to gain a better understanding of the activity of presenting, discovering the potential for a more dynamic, automated, and story-centered approach to prototyping slide presentations that are themselves dynamic in their ability to help presenters rehearse and deliver their story. Our prototype tool for dynamic presentation prototyping, which we call HyperSlides, uses a simple markup language for the creation of hierarchically structured scenes, which are algorithmically transformed into hyperlinked slides of a consistent and minimalist style. Our evaluation suggests that HyperSlides helps idea organization, saves authoring time, creates aesthetic layouts, and supports more flexible rehearsal and delivery than linear slides, at the expense of reduced layout control and increased navigation demands.
Expression Using the T7 RNA Polymerase/Promoter System (1990)

This unit describes the expression of genes by placing them under the control of the bacteriophage T7 RNA polymerase. T7 RNA polymerase is a very active enzyme: it synthesizes RNA at a rate several times that of E. coli RNA polymerase and it terminates transcription less frequently; in fact, its transcription can circumnavigate a plasmid, resulting in RNA several times the plasmid length in size. T7 RNA polymerase is also highly selective for initiation at its own promoter sequences and is resistant to antibiotics such as rifampicin that inhibit E. coli RNA polymerase. Consequently, the addition of rifampicin to cells that are producing T7 RNA polymerase results in the exclusive expression of genes under the control of a T7 RNA polymerase promoter (p(T7)). In the Basic Protocol, two plasmids are maintained within the same E. coli cell. One (the expression vector) contains p(T7) upstream of the gene to be expressed. The second contains the T7 RNA polymerase gene under the control of a heat-inducible E. coli promoter. Upon heat induction, the T7 RNA polymerase is produced and initiates transcription on the expression vector, resulting in turn in the expression of the gene(s) under the control of p(T7). If desired, the gene products can be uniquely labeled by carrying out the procedure in minimal medium, adding rifampicin to inhibit the E. coli RNA polymerase, and then labeling the proteins with [35S]methionine.
<title>Upconversion chirped-pulse amplification of ultrashort pulses using a multimode Tm:ZBLAN fiber</title> (1995)

Microjoule pulse energies are achieved from a single stage upconversion fiber amplifier for the first time in this demonstration of chirped pulse amplification using a multimode Tm:ZBLAN fiber. A Ti:sapphire laser system provides the seed pulse for the upconversion fiber amplifier which produces subpicosecond pulse trains with energies as great as 16 (mu) J at repetition rate of 4.4 kHz. The compressed pulse peak power is more than 1 MW, and the pulse is characterized both temporally and spatially.
Protective effects of inhibitors of nitric oxide synthase in immune complex‐induced vasculitis (1992)

1. The ability of analogues of L-arginine (N-iminoethyl-L-ornithine (L-NIO), NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine methyl ester (L-NAME) and NG-nitro-L-arginine (L-NNA)) to protect against inflammatory injury induced by activated neutrophils was investigated in rats following intradermal or intrapulmonary deposition of immune complexes. 2. The descending order of potency for protective effects of these analogues was: L-NIO > L-NMMA > L-NNA = L-NAME. The approximate IC50 value for L-NIO in the dermal vasculitis model was 65 microM. For all other compounds, the IC50 values were > 5 mM. 3. The protective effect of L-NIO in the skin was reversed in a dose-dependent manner by the presence of L-arginine, but not by D-arginine. L-Arginine also reversed the protective effects of L-NIO in immune complex-induced lung injury. 4. The protective effects of L-NIO were not associated with reductions in neutrophil accumulation, as measured by extraction from tissues of myeloperoxidase. 5. These data demonstrate that L-NIO has the most potent protective effects against immune complex-induced vascular injury induced by activated macrophages. Furthermore, they indicate that this injury is dependent upon the generation of nitric oxide.