gebhart/patrepeval huggingface dataset:
Noninvasive three-dimensional electrocardiographic imaging of ventricular activation sequence (2005)

Imaging the myocardial activation sequence is critical for improved diagnosis and treatment of life-threatening cardiac arrhythmias. It is desirable to reveal the underlying cardiac electrical activity throughout the three-dimensional (3-D) myocardium (rather than just the endocardial or epicardial surface) from noninvasive body surface potential measurements. A new 3-D electrocardiographic imaging technique (3-DEIT) based on the boundary element method (BEM) and multiobjective nonlinear optimization has been applied to reconstruct the cardiac activation sequences from body surface potential maps. Ultrafast computerized tomography scanning was performed for subsequent construction of the torso and heart models. Experimental studies were then conducted, during left and right ventricular pacing, in which noninvasive assessment of ventricular activation sequence by means of 3-DEIT was performed simultaneously with 3-D intracardiac mapping (up to 200 intramural sites) using specially designed plunge-needle electrodes in closed-chest rabbits. Estimated activation sequences from 3-DEIT were in good agreement with those constructed from simultaneously recorded intracardiac electrograms in the same animals. Averaged over 100 paced beats (from a total of 10 pacing sites), total activation times were comparable (53.3 +/- 8.1 vs. 49.8 +/- 5.2 ms), the localization error of site of initiation of activation was 5.73 +/- 1.77 mm, and the relative error between the estimated and measured activation sequences was 0.32 +/- 0.06. The present experimental results demonstrate that the 3-D paced ventricular activation sequence can be reconstructed by using noninvasive multisite body surface electrocardiographic measurements and imaging of heart-torso geometry. This new 3-D electrocardiographic imaging modality has the potential to guide catheter-based ablative interventions for the treatment of life-threatening cardiac arrhythmias.
How we treat a hemophilia A patient with a factor VIII inhibitor (2008)

The most significant complication of treatment in patients with hemophilia A is the development of alloantibodies that inhibit factor VIII activity. In the presence of inhibitory antibodies, replacement of the missing clotting factor by infusion of factor VIII becomes less effective. Once replacement therapy is ineffective, acute management of bleeding requires agents that bypass factor VIII activity. Long-term management consists of eradicating the inhibitor through immune tolerance. Despite success in the treatment of acute bleeding and inhibitor eradication, there remains an inability to predict or prevent inhibitor formation. Ideally, prediction and ultimately prevention will come with an improved understanding of how patient-specific and treatment-related factors work together to influence anti-factor VIII antibody production.
Preferred skin color reproduction based on adaptive affine transform (2005)

This paper models a preferred skin color area with a set of ellipses according to the average luminance of skin and proposes an effective method for skin color reproduction by introducing the affine transform from the skin color ellipse to the preferred skin color ellipse. Also the contour reduction algorithm is described to remove false contours caused by skin color transformation. The visual test is performed to decide the most appropriate preferred skin color for the proposed transformation.
A specific oligonucleotide primer for the rapid detection of Lactobacillus lindneri by polymerase chain reaction (1997)

A polymerase chain reaction (PCR) method was developed for the rapid detection of the beer-spoilage heterofermentative lactic acid bacterium Lactobacillus lindneri. Three strains, the Chinese brewery isolate DA1, the Japanese commercial beer isolate BG2, and the Japanese brewery isolate SE3, which were serologically classified as belonging to L. lindneri, were used in this study. After sequencing the 16S rDNA of the isolates DA1 and BG2 and the typical beer-spoilage heterofermentative Lactobacillus brevis L63, these sequences were compared with published data. A L. lindneri specific PCR primer, DA-40, was then constructed based on the V1 variable region of 16S rDNA. The specificity of PCR using the L. lindneri specific primer DA-40 and the universal primer 907r was examined using five L. lidneri strains: the three isolates described above and two strains from culture collection, DSM 20690 and DSM 20692. A variety of beer-spoilage lactic acid bacteria, including 71 Lactobacillus strains and 13 Pediococcus strains, were also included in this examination. No PCR product was obtained from any DNA with the exception of the five L. lindneri strains, indicating that the L. lindneri specific primer DA-40 was highly specific. The detection limit for L. lindneri in beer was 63 CFU/100 mL of beer.
Phase II trial of depsipeptide (NSC-630176) in colorectal cancer patients who have received either one or two prior chemotherapy regimens for metastatic or locally advanced, unresectable disease: A Southwest Oncology Group study (2006)

3598 The treatment for metastatic colorectal cancer has markedly improved but the disease is still not curable, and additional active agents need to be found. Depsipeptide is a histone deacetylase inhibitor that has shown activity against human solid tumor cell lines and promising results in murine model systems. This phase II trial was undertaken to determine its activity in patients with advanced colorectal cancer. Eligibility requirements included measurable disease, either metastatic or locally advanced and not surgically resectable, Zubrod performance status of 0–1, and adequate renal, hepatic, hematologic and cardiac function. Prior surgery or radiation therapy was allowed and patients were required to have received either one or two prior chemotherapy regimens for advanced disease. A two-stage design was used designed to detect a difference in the null hypothesis of 5% response vs. an alternative 20% response, with 20 eligible patients to be accrued initially followed by an additional 20 patients if one or more confirmed responses were observed. The study closed after the first stage, with 28 patients registered. Three patients are ineligible, two who did not meet requirements for serum magnesium level, and one whose baseline labs were performed more than 14 days prior to registration. One eligible patient never received treatment and is not analyzable for any endpoint. For the 24 eligible and analyzable patients, median age was 58.6 years (range 31–84) with 14 males. Performance status was 0 in 16 patients and 1 in 8. Ten patients received 1 prior chemotherapy regimen and 14 received 2 prior regimens. There were no grade 4 or higher toxicities. The most common grade 2 or 3 toxicities were anorexia, fatigue, nausea, and dehydration. No objective responses were observed. Four patients had stable disease, 15 showed increasing disease, 3 had symptomatic deterioration, and 2 had assessment inadequate. The current Kaplan-Meier estimate of 6 month overall survival is 69% (95% CI 50%-88%) with a median survival of 8.4 months. Depsipeptide does not show significant anti-tumor activity in previously treated patients with advanced colorectal cancer. No significant financial relationships to disclose.
Simultaneous Deprotection and Purification of BOC-amines Based on Ionic Resin Capture (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSimultaneous Deprotection and Purification of BOC-amines Based on Ionic Resin CaptureYun-Shan Liu, Cunxiang Zhao, David E. Bergbreiter, and Daniel RomoView Author Information Department of Chemistry, Texas A&M University, College Station, Texas 77843 Cite this: J. Org. Chem. 1998, 63, 10, 3471–3473Publication Date (Web):April 30, 1998Publication History Received31 October 1997Published online30 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/jo972001ohttps://doi.org/10.1021/jo972001obrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views5113Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Amines,High-performance liquid chromatography,Organic polymers,Purification Get e-Alerts
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae (1998)

Initiation factor eIF4G is an essential protein required for initiation of mRNA translation via the 5' cap-dependent pathway. It interacts with eIF4E (the mRNA 5' cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment of Saccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. We propose that nutritional deprivation or interruption of the TOR signal transduction pathway induces eIF4G degradation.
Chapter 4: Case Study (2013)

Chapter 4 of Library Technology Reports (vol. 49, no. 1) “Resource Sharing in Libraries: Concepts, Products, Technologies, and Trends” presents a case study in which the Orbis Cascade Alliance progressed through a series of configurations of automation implementations to achieve shared strategic goals of its members to effectively share collections and other resources. Note: This case study was adapted and expanded from an earlier article.
STARTLE HABITUATION AND PREPULSE INHIBITION STUDIES IN MUTANT MICE (1999)

s of the First Congress of the Behavioral Pharmacology Society and the European Behavioural Pharmacology Society: PDF Only
Acute Necrotizing Pancreatitis (1999)

Acute pancreatitis may be clinically mild or severe. Severe acute pancreatitis is usually a result of pancreatic glandular necrosis. The morbidity and mortality associated with acute pancreatitis are substantially higher when necrosis is present, especially when the area of necrosis is also infected.1 It is important to identify patients with pancreatic necrosis so that appropriate management can be undertaken. In recent years, the treatment of these patients has shifted away from early surgical débridement (“necrosectomy”) to aggressive intensive medical care, with specific criteria for operative and nonoperative intervention.2,3 Advances in radiologic imaging and aggressive medical management with emphasis on . . .
High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, type of processing, and practice (1997)

Changes in cortical activity during working memory tasks were examined with electroencephalograms (EEGs) sampled from 115 channels and spatially sharpened with magnetic resonance imaging (MRI)-based finite element deblurring. Eight subjects performed tasks requiring comparison of each stimulus to a preceding one on verbal or spatial attributes. A frontal midline theta rhythm increased in magnitude with increased memory load. Dipole models localized this signal to the region of the anterior cingulate cortex. A slow (low-frequency), parietocentral, alpha signal decreased with increased working memory load. These signals were insensitive to the type of stimulus attribute being processed. A faster (higher-frequency), occipitoparietal, alpha signal was relatively attenuated in the spatial version of the task, especially over the posterior right hemisphere. Theta and alpha signals increased, and overt performance improved, after practice on the tasks. Increases in theta with both increased task difficulty and with practice suggests that focusing attention required more effort after an extended test session. Decreased alpha in the difficult tasks indicates that this signal is inversely related to the amount of cortical resources allocated to task performance. Practice-related increases in alpha suggest that fewer cortical resources are required after skill development. These results serve: (i) to dissociate the effects of task difficulty and practice; (ii) to differentiate the involvement of posterior cortex in spatial versus verbal tasks; (iii) to localize frontal midline theta to the anteromedial cortex; and (iv) to demonstrate the feasibility of using anatomical MRIs to remove the blurring effect of the skull and scalp from the ongoing EEG. The results are discussed with respect to those obtained in a prior study of transient evoked potentials during working memory.
Xquery from the Experts: A Guide to the W3c XML Query Language (2003)

From the Publisher:
With the proliferation of XML among corporate IT departments, academic research institutions, and programming operations everywhere, there is a growing need for an XML search and transformation standard with more functionality than Google or XSLT.

Enter XQuery. Backed by the full weight of the World Wide Web Consortium (W3C), is being extremely well received by the IT community worldwide. unlike its predecessors, has the versatility to manipulate both XML and non-XML data and provides a valuable connection between the world of XML and relational databases.

In from the Experts, select members of the W3C's XML Query working group come together to discuss every facet of XQuery. From Jonathan Robie's introductory XQuery: Guided Tour to Mary Fernandez's Discussion of Formal Semantics, is revealed in a way that both novice programmers and industry experts can appreciate.

Edited by long-time XML expert and programmer Howard Katz, coverage ranges from strictly technical chapters to historical essays such as Michael Kay's XQuery and XSLT, which explores the common ancestry of both languages, and Don Chamberlin's Influences on the Design of XQuery, which details the process behind XQuery's design. 

Key coverage includes: 
Denise Draper on Mapping Between XML and Relational Data
Michael Rys exploring Integrating and Relational Database Systems
Jim Tivy's analysis of A Native XML DBMS
Phil Wadler, Jerome Simeon, and Mary Fernandez presenting Static Typing in XQuery
Information presented in both a tutorial and a reference framework for use by XML professionals of anylevel

For IT managers, professionals, programmers, or anyone involved with XML, from the Experts is an invaluable resource.
IL-4-stimulated NF-κB activity is required for Stat6 DNA binding (2007)

IL-4 is a critical cytokine in the regulation of immune responses. In B lymphocytes, IL-4 signaling promotes the Stat6-dependent cell surface expression of several proteins including MHC Class II and CD86. However, the requirement for other transcription factors in IL-4-induced B cell gene expression has not been studied extensively. Here, we show that IL-4 induces NF-kappaB p100 processing to NF-kappaB p52 in B cells but not in T cells or macrophages. IL-4 induced NF-kappaB p52 production requires PI-3K activity and correlates with IkappaB kinase phosphorylation and TNF receptor-associated factor 3 degradation. Blocking NF-kappaB activity eliminates IL-4-stimulated gene expression in B cells by reducing IL-4-induced DNA binding but not phosphorylation or nuclear localization of Stat6. These results describe a novel role for NF-kappaB in IL-4-induced signaling and gene expression.
Intranasal Immunization with Yersinia enterocolitica O:8 Cellular Extract Protects against Local Challenge Infection (1998)

Abstract Yersinia enterocolitica is enteropathogenic for humans and rodents. Immune protection from oral and respiratory pathogens may be most effectively elicited following intranasal (i.n.) vaccination. An experimental murine intranasal challenge model was used to evaluate the immunogenicity of a Y. enterocolitica O:8 cellular extract (CE) in mucosa. This antigenic preparation has demonstrated to induce protection by subcutaneous immunization. Mice were immunized intranasally with two doses of CE. Immunized and nonimmunized animals were challenged with 5×10 6 colony‐forming units (CFU) by nasal infection. Antibodies in serum and bronchoalveolar lavage (b.a.l.) fluid were assessed before and 48 hr after challenge. The CFU were determined by analysis of lung homogenate samples. The CE immunization induced significant b.a.l.‐specific IgA and IgG, and serum‐specific IgG, IgA and IgM. Histopathological studies 24 and 48 hr postchallenge demonstrated that immunization protected against progressive lesions resulting from Y. enterocolitica invasion of the pulmonary mucosa. The CFU in the lungs showed that CE immunization led to significant clearance as compared to the bacterial level in nonimmunized controls. From the results obtained, it can be concluded that CE can induce local and systemic immunity and protect against nasal infection.
A computer program for simulating the patient-physician encounter (1973)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-Print Collections Editorials of Laura Weiss Roberts, MD, MAAM Last PageCOVID-19 and Medical EducationAddressing Race and Racism in Medical EducationeBooksView All For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalAbout the AAMCJournal MastheadSubmit a ManuscriptAdvertising InformationSubscription ServicesReprints and Back IssuesClassified AdsRights and PermissionsFor ReviewersFor MediaFor Trainees All Articles Images Videos Podcasts Blogs Advanced Search
Heart rate reserve is equivalent to%??VO2Reserve, not to%??VO2max (1997)

Percentage of heart rate reserve (%HRR) is widely considered to be equivalent to % of maximal oxygen consumption (%VO2max) for exercise prescription purposes. However, this relationship has not been established in the literature, and a theoretically stronger case can be made for an equivalency between %HRR and %VO2 Reserve (%VO2R) (i.e., the difference between resting and maximal VO2). The current study hypothesized that %HRR is equivalent to %VO2R, not %VO2max, and that the discrepancy between %HRR and %VO2max would be inversely proportional to fitness level. Sixty-three adults performed incremental maximal exercise tests on an electrically braked cycle ergometer. HR and VO2 at rest, at the end of each stage of exercise, and at maximum were used to perform linear regressions on %HRR versus %VO2max, and %HRR versus %VO2R for each subject. For %HRR versus %VO2max, the mean intercept and slope were -11.6 +/- 1.0 and 1.12 +/- 0.01, respectively, which were significantly different (P < 0.001) from 0 and 1, respectively. For %HRR versus %VO2R, the mean intercept and slope were -0.1 +/- 0.6 and 1.00 +/- 0.01, respectively, which were not distinguishable from the line of identity. There was a significant (P < 0.01) inverse relationship between fitness level (VO2max) and the discrepancy between %HRR and %VO2max. In conclusion, %HRR should not be considered equivalent to %VO2max. Rather, %HRR is equivalent to %VO2R, and this relationship should be used in exercise prescription.
An Overview of Human Brucellosis (1995)

Journal Article An Overview of Human Brucellosis Get access Edward J. Young Edward J. Young From the Department of Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas Reprints or correspondence: Dr. Edward J. Young, V.A. Medical Center, 2002 Holcombe Boulevard, Houston, Texas 77030. Search for other works by this author on: Oxford Academic PubMed Google Scholar Clinical Infectious Diseases, Volume 21, Issue 2, August 1995, Pages 283–290, https://doi.org/10.1093/clinids/21.2.283 Published: 01 August 1995 Article history Received: 30 November 1994 Published: 01 August 1995
Predicting Biological Functions of Compounds Based on Chemical-Chemical Interactions (2011)

Given a compound, how can we effectively predict its biological function? It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biological processes and provide useful clues for drug design. In this study, based on the information of chemical-chemical interactions, a novel method was developed that can be used to identify which of the following eleven metabolic pathway classes a query compound may be involved with: (1) Carbohydrate Metabolism, (2) Energy Metabolism, (3) Lipid Metabolism, (4) Nucleotide Metabolism, (5) Amino Acid Metabolism, (6) Metabolism of Other Amino Acids, (7) Glycan Biosynthesis and Metabolism, (8) Metabolism of Cofactors and Vitamins, (9) Metabolism of Terpenoids and Polyketides, (10) Biosynthesis of Other Secondary Metabolites, (11) Xenobiotics Biodegradation and Metabolism. It was observed that the overall success rate obtained by the method via the 5-fold cross-validation test on a benchmark dataset consisting of 3,137 compounds was 77.97%, which is much higher than 10.45%, the corresponding success rate obtained by the random guesses. Besides, to deal with the situation that some compounds may be involved with more than one metabolic pathway class, the method presented here is featured by the capacity able to provide a series of potential metabolic pathway classes ranked according to the descending order of their likelihood for each of the query compounds concerned. Furthermore, our method was also applied to predict 5,549 compounds whose metabolic pathway classes are unknown. Interestingly, the results thus obtained are quite consistent with the deductions from the reports by other investigators. It is anticipated that, with the continuous increase of the chemical-chemical interaction data, the current method will be further enhanced in its power and accuracy, so as to become a useful complementary vehicle in annotating uncharacterized compounds for their biological functions.
Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting (2008)

This study illustrates the therapeutic benefits in a mouse model of human cervical cancer of mechanism-based targeting of the stroma, in particular cancer-associated fibroblasts. Drugs aimed at stromal fibroblast signals and effector functions may prove complementary to conventional treatments targeting the overt cancer cells for a range of solid tumors, possibly including cervical carcinoma, the second most common lethal malignancy in women worldwide, for which management remains poor.