gebhart/patrepeval huggingface dataset:
Low cost, single crystal-like substrates for practical, high efficiency solar cells (1997)

It is well established that high efficiency (20%) solar cells can be routinely fabricated using single crystal photovoltaic (PV) materials with low defect densities. Polycrystalline materials with small grain sizes and no crystallographic texture typically result in reduced efficiencies. This has been ascribed primarily to the presence of grain boundaries and their effect on recombination processes. Furthermore, lack of crystallographic texture can result in a large variation in dopant concentrations which critically control the electronic properties of the material. Hence in order to reproducibly fabricate high efficiency solar cells a method which results in near single crystal material is desirable. Bulk single crystal growth of PV materials is cumbersome, expensive and difficult to scale up. We present here a possible route to achieve this if epitaxial growth of photovoltaic materials on rolling-assisted-biaxially-textured-substrates (RABiTS) can be achieved. The RABiTS process uses well-established, industrially scaleable, thermomechanical processing to produce a biaxially textured or single-crystal-like metal substrate with large grains (50–100 μm). This is followed by epitaxial growth of suitable buffer layers to yield chemically and structurally compatible surfaces for epitaxial growth of device materials. Using the RABiTS process it should be possible to economically fabricate single-crystal-like substrates of desired sizes. Epitaxial growth of photovoltaic devices on such substrates presents a possible route to obtaining low-cost, high performance solar cells.
Mixed-Reality Simulation for Neurosurgical Procedures (2013)

The system has provided the residents an opportunity to understand and appreciate the complex 3-dimensional anatomy of the 3 neurosurgical procedures simulated. The systems have also provided an opportunity to break procedures down into critical segments, allowing the user to concentrate on specific areas of deficiency.
Hair removal with long pulsed diode lasers: A comparison between two systems with different pulse structures (2003)

No statistically significant differences in hair removal efficacy were observed. These results agree with mathematical modeling, which also offers a method to estimate hair removal efficacy and adverse effects for a range of hair characteristics and laser parameters.
The use of self-assembled monolayers and a selective etch to generate patterned gold features (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe use of self-assembled monolayers and a selective etch to generate patterned gold featuresAmit Kumar, Hans A. Biebuyck, Nicholas L. Abbott, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1992, 114, 23, 9188–9189Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/ja00049a061https://doi.org/10.1021/ja00049a061research-articleACS PublicationsRequest reuse permissionsArticle Views950Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis (2015)

NCT02280616; EudraCT number, 2009-016692-29.
MicroRNA-Cancer Connection: The Beginning of a New Tale (2006)

Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. Their expression profiles can be used for the classification, diagnosis, and prognosis of human malignancies. Loss or amplification of miRNA genes has been reported in a variety of cancers, and altered patterns of miRNA expression may affect cell cycle and survival programs. Germ-line and somatic mutations in miRNAs or polymorphisms in the mRNAs targeted by miRNAs may also contribute to cancer predisposition and progression. We propose that alterations in miRNA genes play a critical role in the pathophysiology of many, perhaps all, human cancers.
Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor beta-D-GalNAc(1-->4)beta-D-Gal analogs. (1998)

Pseudomonas aeruginosa employs pili to mediate adherence to epithelial cell surface receptors. Previously, it has been shown that the pilus adhesin of P. aeruginosa PAK binds to the ganglioside asialo-GM1. In particular, it was found that the carbohydrate sequence beta-D-GalNAc(1-->4)beta-D-Gal is the minimal carbohydrate receptor sequence of asialo-GM1. To study the binding specificity of P. aeruginosa, O-modified and N-modified sugar analogs, where each hydroxyl group was substituted either by O-methyl or O-propyl and the acetamido group was changed to a propionamido group, were synthesized. The sugar analogs were evaluated as inhibitors in a competitive solid phase binding assay. The results demonstrate that the pili of P. aeruginosa PAK accepts a variety of sugar analogs possessing the sequence beta-D-GalNAc(1-->4)beta-D-Gal. Most sugar analogs bind with a similar order of magnitude (50% inhibitory concentration (IC50) = 60-130 microM) except for the 2-O-propyl derivative 7 (IC50 = 8 +/- 4 microM) compared with an IC50 of 79 +/- 18 microM for the native compound. The significant increase in binding affinity of 2-O-propyl derivative 7 suggests that improved inhibitors of adhesion may be prepared by introducing a hydrophobic side chain at the 2-position of galactose.
Evaluation of the effect of shape on a contemporary CAD system (2008)

The TracerCAD system is one of the leading prosthetic CAD systems in the world and is increasingly used in clinics to replace traditional methods of residual limb shape capture. Accurate dimensional capture of the residuum is arguably the most important process in the production of a prosthetic socket. TracerCAD system accuracy has previously been tested on a cylindrical model but not a trans-tibial shape. Residual limbs are irregular in shape therefore it is important to assess if shape has an effect on the accuracy of data collected when using TracerCAD. The objective of this study is to investigate the accuracy of the TracerCAD system in measuring a model of a trans-tibial stump of known dimensions and volume. A model of a trans-tibial stump was produced and filled with plaster and measured using a data acquisition system with an accuracy of five micron (0.005 mm). The model was repeatedly traced using the TracerCAD system by an individual user. The mean value of measures taken by the dynamic indicator was calculated and compared to individual and mean values of TracerCAD measurement. Results showed that the TracerCAD measurement was not as consistent on the more complex trans-tibial model as for the cylindrical model.
An origami-inspired ultrastretchable bioprobe film device (2016)

We have developed an ~1,000% stretchable and flexible bioprobe film device, which enables to follow the shape of a spherical and deformable biological tissue while the electrical signals are recorded (Fig. 1). As the film material, we use a highly-biocompatible parylene film, which shows the high stretchability by embedding slit patterns in the film, so call `Amanogawa' design in traditional `Origami (or Kirigami)'. The fabricated 10-μm-thick parylene film exhibits the stretchability of 1,100%. In addition, the parylene film-based bioprobe device is fabricated for in vivo electrocardiogram (ECoG) recordings of a mouse brain. We demonstrate the simultaneous ECoG recordings from both the visual and sensory cortices by stretching the film and changing the electrode gap, indicating that the recording capability of the electrodes while the film stretches.
Trust Region Policy Optimization (2015)

We describe an iterative procedure for optimizing policies, with guaranteed monotonic improvement. By making several approximations to the theoretically-justified procedure, we develop a practical algorithm, called Trust Region Policy Optimization (TRPO). This algorithm is similar to natural policy gradient methods and is effective for optimizing large nonlinear policies such as neural networks. Our experiments demonstrate its robust performance on a wide variety of tasks: learning simulated robotic swimming, hopping, and walking gaits; and playing Atari games using images of the screen as input. Despite its approximations that deviate from the theory, TRPO tends to give monotonic improvement, with little tuning of hyperparameters.
Hypoxia-inducible Protein Binding to Vascular Endothelial Growth Factor mRNA and Its Modulation by the von Hippel-Lindau Protein (1996)

Hypoxia induces an increase in the stability of the mRNA encoding vascular endothelial growth factor (VEGF). We have previously demonstrated that a 500-base region of the 3'-untranslated region of VEGF mRNA that is critical for stabilization of VEGF mRNA in an in vitro degradation assay forms a RNA-protein complex in a hypoxia-inducible fashion. We report here the identification of three adenylate-uridylate-rich RNA elements within this region that form an identical or closely related hypoxia-inducible RNA-protein complex. This complex is constitutively elevated in a tumor cell line lacking the wild type von Hippel-Lindau tumor suppressor gene and in which VEGF mRNA is constitutively stabilized. Furthermore, the glucose transporter-1 mRNA, which is also stabilized by hypoxia, forms a hypoxia-inducible RNA-protein complex with similar sequence and protein binding characteristics to that described for VEGF mRNA. Finally, RNA affinity purification and UV cross-linking were used to identify three proteins of 32, 28, and 17 kDa that are derived from this hypoxia-inducible RNA-protein complex.
Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease (1996)

The risk of solid tumors, especially breast cancer, is high among women who were treated with radiation for childhood Hodgkin's disease. Systematic screening for breast cancer could be important in the health care of such women.
Human Endometrial Epithelial Cells Modulate the Activation of Gelatinase A by Stromal Cells (2002)

Metalloproteinases (MMPs) are central effectors in endometrial physiology. Their production is tightly regulated by ovarian steroids and cytokines. Using zymography, we investigated MMP-2 production by human endometrial cells treated with estradiol-17beta + progesterone (E(2)+P) and by various key cytokines in endometrial physiology (IL-1beta, LIF, TGF-beta, and TNF-alpha). No gelatinase activity was detected in the culture media of epithelial cells. In basal conditions, stromal cells produced the pro form of MMP-2. MMP-2 production/activation was not directly affected by cytokine treatment. Interestingly, activated MMP-2 was only detected after treatment of stromal cells with culture medium from epithelial cells. Cytokine treatment of epithelial cells increased the capacity of conditioned medium to stimulate stromal cells to activate MMP-2. As the tissue inhibitor of MMP-2 (TIMP-2) is a regulator of gelatinase A activity, its concentration was measured by ELISA. TIMP-2 production by stromal cells was not affected by cytokines or by epithelial cell-conditioned medium. These results strongly suggest that regulation of stromal MMP-2 activation involves soluble factor(s) derived from the epithelial compartment.
Structural Instability of Driven Josephson Circuits Prevented by an Inductive Shunt (2019)

Strongly driven superconducting circuits are a versatile platform to implement a multitude of Hamiltonians for quantum computation, simulation, and sensing. Unfortunately, they can display complex dynamics with instabilities, so predicting and preventing these instabilities is crucial for applications. This paper proposes an inductively shunted transmon qubit as the elementary circuit optimized for strong parametric drives. Developing a numerical approach that avoids the limitations of perturbative analysis, the authors demonstrate that adding the inductive shunt significantly extends the range of pump powers in which the circuit is stable.
Thyroid Allograft Immunogenicity Is Reduced After a Period in Organ Culture (1975)

The survival time of mouse thyroid, transplanted under the kidney capsule of an H-2 incompatible recipient, is extended by holding the thyroid in organ culture for 12 days prior to transplantation.
Classification TV programs based on audio information using hidden Markov model (2002)

This paper describes a technique for classifying TV broadcast video using a hidden Markov model (HMM). Here we consider the problem of discriminating five types of TV programs, namely commercials, basketball games, football games, news reports, and weather forecasts. Eight frame-based audio features are used to characterize the low-level audio properties, and fourteen clip-based audio features are extracted based on these frame-based features to characterize the high-level audio properties. For each type of these five TV programs, we build an ergodic HMM using the clip-based features as observation vectors. The maximum likelihood method is then used for classifying testing data using the trained models.
Mass transfer effects in a nitric oxide dosimeter (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMass transfer effects in a nitric oxide dosimeterJ. S. Nadeau, M. E. Treen, and D. G. B. BoocockCite this: Anal. Chem. 1978, 50, 13, 1871–1873Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/ac50035a035https://doi.org/10.1021/ac50035a035research-articleACS PublicationsRequest reuse permissionsArticle Views42Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metformin revisited: re‐evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents (2004)

Metformin remains a safe and effective agent for the therapy of patients with type 2 DM. It is useful as monotherapy or in combination regimens with the newer insulin secretagogues, TZDs or insulin. It is still in most circumstances the agent of choice for initial therapy of the typical obese patient with type 2 DM and mild to moderate hyperglycaemia.
OPERÁRIOS NA CONSTRUÇÃO DE GOIÂNIA (2013)

Publicado, anteriormente, no Encarte do “Jornal Opcao” em 24 de outubro de 1980, o texto, a partir de fontes da epoca da construcao de Goiânia, trabalha a questao do operario naquele momento. Apresentando as dificuldades e mesmo a penuria em viveu o operariado, bem como sua movimentacao politica e greves, resgata a importância do trabalhador na construcao da nova capital goiana, ignorado pela historiografia tradicional.
New immune strategies for the treatment of acute lymphoblastic leukemia: antibodies and chimeric antigen receptors (2013)

The prognosis of adult acute lymphoblastic leukemia (ALL) remains poor and novel treatment strategies are needed. Antibody-based therapies represent such an approach. ALL cells express various surface antigens that are targets for monoclonal antibodies. This review focuses on 4 major classes of antibody therapy: (1) naked antibodies, (2) T-cell-engaging bispecific single-chain antibodies, (3) immunoconjugates/immunotoxins, and (4) chimeric antigen receptors. Preclinical and clinical data are reviewed. This area of research represents an exciting new approach to help improve the outcome of this disease. Several clinical trials are currently incorporating this therapy in the treatment of newly diagnosed and relapsed adult ALL patients.
Beam tracing polygonal objects (1984)

Ray tracing has produced some of the most realistic computer generated pictures to date. They contain surface texturing, local shading, shadows, reflections and refractions. The major disadvantage of ray tracing results from its point-sampling approach. Because calculation proceeds ab initio at each pixel it is very CPU intensive and may contain noticeable aliasing artifacts. It is difficult to take advantage of spatial coherence because the shapes of reflections and refractions from curved surfaces are so complex. In this paper we describe an algorithm that utilizes the spatial coherence of polygonal environments by combining features of both image and object space hidden surface algorithms. Instead of tracing infinitesimally thin rays of light, we sweep areas through a scene to form “beams.” This technique works particularly well for polygonal models since for this case the reflections are linear transformations, and refractions are often approximately so. The recursive beam tracer begins by sweeping the projection plane through the scene. Beam-surface intersections are computed using two-dimensional polygonal set operations and an occlusion algorithm similar to the Weiler-Atherton hidden surface algorithm. For each beam-polygon intersection the beam is fragmented and new beams created for the reflected and transmitted swaths of light. These sub-beams are redirected with a 4×4 matrix transformation and recursively traced. This beam tree is an object space representation of the entire picture. Since the priority of polygons is pre-determined, the final picture with reflections, refractions, shadows, and hidden surface removal is easily drawn. The coherence information enables very fast scan conversion and high resolution output. Image space edge and texture antialiasing methods can be applied.
Effect of Vitamin K2 on Three-Dimensional Trabecular Microarchitecture in Ovariectomized Rats (2000)

Menatetrenone, a vitamin K2 with four isoprene units, has been reported to improve osteoporotic bone loss. The purpose of this investigation was to clarify the effect of menatetrenone on the three-dimensional (3D) trabecular microarchitecture in ovariectomized (OVX) rats by using microcomputed tomography (MCT). Forty-two 13-week-old female rats were used and divided into four groups: the OVX (OVX + MK-4) group treated with menatetrenone, the (OVX untreated) group, the sham-operated (Sham + MK-4) group treated with menatetrenone, and the sham-operated group not treated with menatetrenone (Sham untreated) group. OVX rats were fed a calcium-deficient diet. Menatetrenone treatment was begun just after the ovariectomy, and the mean menatetrenone oral intake over the 8-week period was adjusted to 30 mg/kg BW per day. The proximal metaphyseal region of the right tibia was evaluated by dual X-ray absorptiometry (DXA) and MCT. A parametric analysis of the reconstructed trabecular volume was carried out using bone volume fractions, the fractal dimension calculated by the 3D box-counting method, and the connectivity density as determined by topological analysis. Menatetrenone significantly increased the trabecular bone volume, fractal dimension, and connectivity in the OVX + MK-4 group compared with the OVX-untreated group (p < 0.01). Our results suggest that an 8-week administration of menatetrenone protects against the loss of trabecular bone volume and its connectivity when treatment is begun just after the ovariectomy. Despite this apparent protection, it remains unknown whether it is possible to reestablish trabecular connectivity if therapeutic intervention occurs after the trabecular connectivity has been lost.
Cannabinoids in the treatment of epilepsy – an updated review (2019)

Sciendo provides publishing services and solutions to academic and professional organizations and individual authors. We publish journals, books, conference proceedings and a variety of other publications.
Digital color imaging (1997)

This paper surveys current technology and research in the area of digital color imaging. In order to establish the background and lay down terminology, fundamental concepts of color perception and measurement are first presented using vector-space notation and terminology. Present-day color recording and reproduction systems are reviewed along with the common mathematical models used for representing these devices. Algorithms for processing color images for display and communication are surveyed, and a forecast of research trends is attempted. An extensive bibliography is provided.
Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice (1995)

Megakaryocyte growth and development factor (MGDF) is a potent inducer of megakaryopoiesis in vitro and thrombopoiesis in vivo. The effects of MGDF appear to be lineage-selective, making this cytokine an ideal candidate for use in alleviating clinically relevant thrombocytopenias. This report describes a murine model of life-threatening thrombocytopenia that results from the combination treatment of carboplatin and sublethal irradiation. Mortality of this regimen is 94% and is associated with widespread internal bleeding. The daily administration of pegylated recombinant human MGDF (PEG-rMGDF) significantly reduced mortality (to < 15%) and ameliorated the depth and duration of thrombocytopenia. The severity of leucopenia and anemia was also reduced, although it was not clear whether these effects were direct. Platelets generated in response to PEG-rMGDF were morphologically indistinguishable from normal platelets. PEG-rMGDF administered in combination with murine granulocyte colony-stimulating factor completely prevented mortality and further reduced leukopenia and thrombocytopenia. These data support the concept that PEG-rMGDF may be useful to treat iatrogenic thrombocytopenias.