gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of (1α,5α,6α)‐6‐Amino‐3‐azabicyclo(3.1.0) hexane, a Novel Achiral Diamine. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental investigation of ultrashort pulse laser-induced breakdown thresholds in aqueous media (1996)

Laser-induced breakdown (LIE) thresholds are determined for pulse durations of 2.4 ps, 400 fs, and 100 fs at 580 mn in high purity water, saline and tap water. The dependence of LIE irradiance thresholds on pulse duration, optical wavelength, and focal volume is examined, and the experimental data obtained is compared with a theoretical model. The slopes of the probability curves calculated are compared with mechanisms for LIE, namely avalanche ionization, multiphoton initiated avalanche ionization, and multiphoton ionization. Lastly, the dependence of the peak breakdown electric field on pulse duration and focal volume is empirically determined and compared with previous work.
New Ursolic and Betulinic Derivatives as Potential Cytotoxic Agents (2003)

Fifteen new ursolic and betulinic triterpenoids, bearing various functionalities at C-3 and C-28 were synthesized as potential cytotoxic agents. All compounds were obtained by a hemisynthetic route via ursolic and betulinic acids. Preliminary screening of these compounds on human HT 29 colon cancer cells revealed inhibitory activity for three of them. Beta-D-Glucopyranosyl-3beta-hydroxyurs-12(13)-en-28-oate 1c, 3beta-3-(3-pyridyl)-prop-2-enoyloxyurs-12(13)-en-28-oic acid 1i and the potassium salt of 3beta-cinnamoyloxylup-20(29)-en-28-oic acid 2d demonstrated cytotoxic activity in the micromolar range: 8.0, 45.0 and 8.0 microM, respectively.
A Multiplicative Regularization Approach for Deblurring Problems (2004)

In this work, an iterative inversion algorithm for deblurring and deconvolution is considered. The algorithm is based on the conjugate gradient scheme and uses the so-called weighted L2-norm regularizer to obtain a reliable solution. The regularizer is included as a multiplicative constraint. In this way, the appropriate regularization parameter will be controlled by the optimization process itself. In fact, the misfit in the error in the space of the blurring operator is the regularization parameter. Then, no a priori knowledge on the blurred data or image is needed. If noise is present, the misfit in the error consisting of the blurring operator will remain at a large value during the optimization process; therefore, the weight of the regularization factor will be more significant. Hence, the noise will, at all times, be suppressed in the reconstruction process. Although one may argue that, by including the regularization factor as a multiplicative constraint, the linearity of the problem has been lost, careful analysis shows that, under certain restrictions, no new local minima are introduced. Numerical testing shows that the proposed algorithm works effectively and efficiently in various practical applications.
Body Fat Distribution and Insulin Resistance: Beyond Obesity in Nonalcoholic Fatty Liver Disease among Overweight Men (2007)

Our study provides evidence for a profound and dose-dependent association of NAFLD with central adiposity, insulin resistance in overweight men lacking complications of metabolic syndrome. Overweight subjects with insulin resistance or central adiposity were at more risk of NAFLD than were those subjects with less insulin resistance or central adiposity, even those with a similar degree of obesity.
G Protein-Coupled Receptors in Anopheles gambiae (2002)

We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
Hybrid ARQ with Random Thansmission Assignments. (2003)

In mobile packet data and voice networks, a special coding scheme, known as the incremental redundancy hybrid ARQ (IR HARQ), achieves higher throughput efficiency than ordinary turbo codes by adapting its error correcting code redundancy to fluctuating channel conditions characteristic for this application. An IR HARQ protocol operates as follows. Initially, the information bits are encoded by a “mother” code and a selected number of parity bits are transmitted. If a retransmission is requested, only additional selected parity bits are transmitted. At the receiving end, the additional parity bits are combined with the previously received bits, allowing for an increase in the error correction capacity. This procedure is repeated after each subsequent retransmission request until the entire codeword of the mother code is transmitted. A number of important issues such as error rate performance after each transmission on time varying channels, and rate and power control are difficult to analyze in a network employing a particular HARQ scheme, i.e., a given mother code and given selection of bits for each transmission. By relaxing only the latter constraint, namely, by allowing random selection of the bits for each transmission, we provide very good estimates of error rates allowing us to address to a certain extent the rate and power control problem.
Catalytic Enantioselective Synthesis of β2-Amino Acids This work was supported by the National Science Foundation (CHE 0092490) and the National Institutes of Health (GM57425). (2002)

Einen direkten Zugang zu β-Aminosäureestern eröffnet die katalytische asymmetrische C-H-Aktivierung durch Carbenoid-induzierte Insertion in eine C-H-Bindung (siehe Schema; Boc=Butoxycarbonyl, TFA=Trifluoressigsäure). Die hier beschriebenen Reaktionen liefern das erste Beispiel für eine regioselektive intermolekulare C-H-Insertion an einer Methylgruppe.
Chromosomal DNA replication initiates at the same origins in meiosis and mitosis. (1994)

Autonomously replicating sequence (ARS) elements are identified by their ability to promote high-frequency transformation and extrachromosomal replication of plasmids in the yeast Saccharomyces cerevisiae. Six of the 14 ARS elements present in a 200-kb region of Saccharomyces cerevisiae chromosome III are mitotic chromosomal replication origins. The unexpected observation that eight ARS elements do not function at detectable levels as chromosomal replication origins during mitotic growth suggested that these ARS elements may function as chromosomal origins during premeiotic S phase. Two-dimensional agarose gel electrophoresis was used to map premeiotic replication origins in a 100-kb segment of chromosome III between HML and CEN3. The pattern of origin usage in premeiotic S phase was identical to that in mitotic S phase, with the possible exception of ARS308, which is an inefficient mitotic origin associated with CEN3. CEN3 was found to replicate during premeiotic S phase, demonstrating that the failure of sister chromatids to disjoin during the meiosis I division is not due to unreplicated centromeres. No origins were found in the DNA fragments without ARS function. Thus, in both mitosis and meiosis, chromosomal replication origins are coincident with ARS elements but not all ARS elements have chromosomal origin function. The efficiency of origin use and the patterns of replication termination are similar in meiosis and in mitosis. DNA replication termination occurs over a broad distance between active origins.
Prevention of cardiac sudden death by N‐3 fatty acids: a review of the evidence (1996)

The essential n-6 and n-3 polyunsaturated fatty acids can prevent ischaemia-induced ventricular fibrillation in rats, dogs and marmosets. In isolated neonatal rat cardiac myocytes, these have been shown to prevent tachyarrhythmias caused by elevated calcium concentrations, toxic levels of ouabain, a beta-adrenergic agent (isoproterenol), lysophosphatidylcholine and acylcarnitine. The antiarrhythmic effect is caused by a reduction in electrical excitability caused by partitioning of the free polyunsaturated fatty acids into the phospholipid cell membranes of the cardiac myocytes, which modulates membrane ion channels. Two clinical trials suggest they could prevent sudden cardiac death in humans.
The ovalbumin gene: cloning and molecular organization of the entire natural gene. (1979)

We report the analyses of recently cloned restriction fragments of the natural ovalbumin gene that overlap in part with previously cloned DNA fragments but extend further into the flanking sequences of the gene. These clones now permit us to identify the DNA sequence that codes for the 5' end of ovalbumin mRNA. Based on these and previous results, the molecular organization of the entire ovalbumin gene was established. The entire gene is composed of eight structural DNA sequences separated by seven intervening sequences that are not present in the mature mRNA. In addition, an ovalbumin gene clone has been obtained from a chicken gene library. Analysis of DNA isolated from this particular clone by molecular hybridization and electron microscopic mapping revealed that it contains the entire ovalbumin gene a single segment of DNA and its structure was consistent with that predicted from our physical map constructed from individually cloned fragments of the gene.
Synthesis and excited‐state photodynamics of phenylethyne‐linked porphyrin–phthalocyanine dyads (2000)

Free base, zinc and magnesium mono-ethynyl phthalocyanines have been prepared as building blocks for constructing phthalocyanine-containing molecular devices. The phthalocyanine building blocks were prepared by the statistical reaction of 4,5-diheptylphthalonitrile and 4-(3-hydroxy-3-methylbut-1-ynyl)phthalonitrile, followed by chromatographic separation and subsequent deprotection. Seven porphyrin–phthalocyanine dyads in various metalation states have been prepared (M1PM2Pc; M1, M2 = Zn2+, Mg2+, or 2H+). ZnPH2Pc and ZnPZnPc were synthesized by Pd-coupling reactions of an ethynylphthalocyanine and an iodoporphyrin. Five other dyads (H2PH2Pc, MgPH2Pc, MgPMgPc, H2PMgPc, ZnPMgPc) were prepared by selective metalation and demetalation reactions starting from ZnPH2Pc, based on the stability differences of metalloporphyrins and metallophthalocyanines. Transient absorption and static emission experiments indicate the following: (1) Excited singlet-state intramolecular energy transfer from the porphyrin to the phthalocyanine moiety is very fast (≤10 ps). (2) The efficiency of the energy-transfer process is very high (typically ≥90%), and is greatest in dyads in which competing charge transfer is inhibited on energetic grounds (e.g. >98% for H2PH2Pc). (3) Charge transfer involving the excited phthalocyanine and the porphyrin occurs to a limited degree (typically <10%) depending on the redox characteristics of the chromophores. (4) The desirable strong emission properties of monomeric phthalocyanines are retained in most of the dyads (Φf = 0.37–0.75). This paper establishes the foundation for utilizing phthalocyanines as strong-red absorbers, energy-transfer acceptors, and bright emitters in conjunction with porphyrin-based molecular photonic devices.
High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting (2012)

The ability to track microbes in real time in vivo is of enormous value for preclinical investigations in infectious disease or gene therapy research. Bacteria present an attractive class of vector for cancer therapy, possessing a natural ability to grow preferentially within tumours following systemic administration. Bioluminescent Imaging (BLI) represents a powerful tool for use with bacteria engineered to express reporter genes such as lux. BLI is traditionally used as a 2D modality resulting in images that are limited in their ability to anatomically locate cell populations. Use of 3D diffuse optical tomography can localize the signals but still need to be combined with an anatomical imaging modality like micro-Computed Tomography (μCT) for interpretation.In this study, the non-pathogenic commensal bacteria E. coli K-12 MG1655 and Bifidobacterium breve UCC2003, or Salmonella Typhimurium SL7207 each expressing the luxABCDE operon were intravenously (i.v.) administered to mice bearing subcutaneous (s.c) FLuc-expressing xenograft tumours. Bacterial lux signal was detected specifically in tumours of mice post i.v.-administration and bioluminescence correlated with the numbers of bacteria recovered from tissue. Through whole body imaging for both lux and FLuc, bacteria and tumour cells were co-localised. 3D BLI and μCT image analysis revealed a pattern of multiple clusters of bacteria within tumours. Investigation of spatial resolution of 3D optical imaging was supported by ex vivo histological analyses. In vivo imaging of orally-administered commensal bacteria in the gastrointestinal tract (GIT) was also achieved using 3D BLI. This study demonstrates for the first time the potential to simultaneously image multiple BLI reporter genes three dimensionally in vivo using approaches that provide unique information on spatial locations.
Characterizations of Highly Expressed Genes of Four Fast-Growing Bacteria (2001)

Predicted highly expressed (PHX) genes are characterized for the completely sequenced genomes of the four fast-growing bacteria Escherichia coli, Haemophilus influenzae, Vibrio cholerae, and Bacillus subtilis. Our approach to ascertaining gene expression levels relates to codon usage differences among certain gene classes: the collection of all genes (average gene), the ensemble of ribosomal protein genes, major translation/transcription processing factors, and genes for polypeptides of chaperone/degradation complexes. A gene is predicted highly expressed (PHX) if its codon frequencies are close to those of the ribosomal proteins, major translation/transcription processing factor, and chaperone/degradation standards but strongly deviant from the average gene codon frequencies. PHX genes identified by their codon usage frequencies among prokaryotic genomes commonly include those for ribosomal proteins, major transcription/translation processing factors (several occurring in multiple copies), and major chaperone/degradation proteins. Also PHX genes generally include those encoding enzymes of essential energy metabolism pathways of glycolysis, pyruvate oxidation, and respiration (aerobic and anaerobic), genes of fatty acid biosynthesis, and the principal genes of amino acid and nucleotide biosyntheses. Gene classes generally not PHX include most repair protein genes, virtually all vitamin biosynthesis genes, genes of two-component sensor systems, most regulatory genes, and most genes expressed in stationary phase or during starvation. Members of the set of PHX aminoacyl-tRNA synthetase genes contrast sharply between genomes. There are also subtle differences among the PHX energy metabolism genes between E. coli and B. subtilis, particularly with respect to genes of the tricarboxylic acid cycle. The good agreement of PHX genes of E. coli and B. subtilis with high protein abundances, as assessed by two-dimensional gel determination, is verified. Relationships of PHX genes with stoichiometry, multifunctionality, and operon structures are also examined. The spatial distribution of PHX genes within each genome reveals clusters and significantly long regions without PHX genes.
Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children (2004)

Human metapneumovirus infection is a leading cause of respiratory tract infection in the first years of life, with a spectrum of disease similar to that of respiratory syncytial virus.
Reclassification of Pseudomonas aurantiaca as a synonym of Pseudomonas chlororaphis and proposal of three subspecies, P. chlororaphis subsp. chlororaphis subsp. nov., P. chlororaphis subsp. aureofaciens subsp. nov., comb. nov. and P. chlororaphis subsp. aurantiaca subsp. nov., comb. nov. (2007)

Pseudomonas chlororaphis, Pseudomonas aureofaciens and Pseudomonas aurantiaca were considered as separate species until 1989, when P. aureofaciens was proposed as a later heterotypic synonym of P. chlororaphis with P. aurantiaca remaining as a separate species. Nevertheless, analysis of the almost complete 16S rRNA gene sequences revealed that the type strain of P. aurantiaca, NCIMB 10068(T), shows gene sequence similarities close to 99.5 % with respect to P. chlororaphis DSM 50083(T) and P. aureofaciens DSM 6698(T). DNA-DNA hybridization experiments among strains of P. aurantiaca, P. chlororaphis and P. aureofaciens showed values higher than 70 %, confirming that they represent members of the same species. The results of fatty acid analysis and phenotypic traits showed that these strains are closely related, although there are some differences among the strains belonging to P. aurantiaca, those from P. chlororaphis and those from P. aureofaciens. All these results confirm the previous reclassification of P. aureofaciens into P. chlororaphis and support the reclassification of P. aurantiaca as a synonym of P. chlororaphis. Phenotypic and molecular data permit the description of three novel subspecies within this last species, for which the following names are proposed: P. chlororaphis subsp. chlororaphis subsp. nov. [with the type strain DSM 50083(T) (=ATCC 9446(T)=NCIMB 9392(T))], P. chlororaphis subsp. aureofaciens subsp. nov., comb. nov. [with the type strain DSM 6698(T) (=ATCC 13985(T)=NCIMB 9030(T))] and P. chlororaphis subsp. aurantiaca subsp. nov., comb. nov. [with the type strain NCIMB 10068(T) (=ATCC 33663(T)=CIP 106718(T))].
The VoodooIO gaming kit (2006)

Existing gaming controllers are limited in their end-user configurability. As a complement to current game control technology, we present the VoodooIO Gaming Kit, a real-time adaptable gaming controller. We introduce the concept of appropriable gaming devices, which allow players to define and actively reconfigure their gaming space, making it appropriate to their personal preference and gaming needs. The technology and its conceived usage are illustrated through its application to two commercially available computer games, as well as through the results of a formal user study.
HIV-1 Antiretroviral Drug Therapy (2012)

The most significant advance in the medical management of HIV-1 infection has been the treatment of patients with antiviral drugs, which can suppress HIV-1 replication to undetectable levels. The discovery of HIV-1 as the causative agent of AIDS together with an ever-increasing understanding of the virus replication cycle have been instrumental in this effort by providing researchers with the knowledge and tools required to prosecute drug discovery efforts focused on targeted inhibition with specific pharmacological agents. To date, an arsenal of 24 Food and Drug Administration (FDA)-approved drugs are available for treatment of HIV-1 infections. These drugs are distributed into six distinct classes based on their molecular mechanism and resistance profiles: (1) nucleoside-analog reverse transcriptase inhibitors (NNRTIs), (2) non-nucleoside reverse transcriptase inhibitors (NNRTIs), (3) integrase inhibitors, (4) protease inhibitors (PIs), (5) fusion inhibitors, and (6) coreceptor antagonists. In this article, we will review the basic principles of antiretroviral drug therapy, the mode of drug action, and the factors leading to treatment failure (i.e., drug resistance).
LRP: a multifunctional scavenger and signaling receptor (2001)

Multiligand receptorsLigand families and subgroups and their binding sites on LRP LRP recognizes at least 30 different ligands (Table 1) that represent several families of proteins.These include lipoproteins, proteinases, proteinaseinhibitor complexes, ECM proteins, bacterial toxins, viruses, and various intracellular proteins.
Long-term Outcomes for Living Pancreas Donors in the Modern Era (2016)

LDSPTx can be performed with good recipient outcomes. The donation is associated with donor morbidity including impaired glucose control. Donor morbidity can be minimized by using RSM and predonation counseling on life style modifications postdonation.
Boosting the margin: a new explanation for the effectiveness of voting methods (1998)

One of the surprising recurring phenomena observed in experiments with boosting is that the test error of the generated classifier usually does not increase as its size becomes very large, and often is observed to decrease even after the training error reaches zero. In this paper, we show that this phenomenon is related to the distribution of margins of the training examples with respect to the generated voting classification rule, where the margin of an example is simply the difference between the number of correct votes and the maximum number of votes received by any incorrect label. We show that techniques used in the analysis of Vapnik’s support vector classifiers and of neural networks with small weights can be applied to voting methods to relate the margin distribution to the test error. We also show theoretically and experimentally that boosting is especially effective at increasing the margins of the training examples. Finally, we compare our explanation to those based on the bias-variance decomposition.
Occipital‐Callosal Pathways in Children: Validation and Atlas Development (2005)

Diffusion tensor imaging and fiber tracking were used to measure fiber bundles connecting the two occipital lobes in 53 children of 7-12 years of age. Independent fiber bundle estimates originating from the two hemispheres converge onto the lower half of the splenium. This observation validates the basic methodology and suggests that most occipital-callosal fibers connect the two occipital lobes. Within the splenium, fiber bundles are organized in a regular pattern with respect to their cortical projection zones. Visual cortex dorsal to calcarine projects through a large band that fills much of the inferior half of the splenium, while cortex ventral to calcarine sends projections through a band at the anterior inferior edge of the splenium. Pathways projecting to the occipital pole and lateral-occipital regions overlap the dorsal and ventral groups slightly anterior to the center of the splenium. To visualize these pathways in a typical brain, we combined the data into an atlas. The estimated occipital-callosal fiber paths from the atlas form the walls of the occipital horn of the lateral ventricle, with dorsal paths forming the medial wall and the ventral paths bifurcating into a medial tract to form the inferior-medial wall and a superior tract that joins the lateral-occipital paths to form the superior wall of the ventricle. The properties of these fiber bundles match those of the hypothetical pathways described in the neurological literature on alexia.