gebhart/patrepeval huggingface dataset:
Model Updating - Endless Possibilities, #381 (2000)

Finite element models are updated using test data to better represent the actual as-built characteristics of a system or prototype. Using commercially available software, a detailed finite element model can be easily updated to reflect the measured characteristics - whether they be frequencies, mode shapes or response functions. However, the accuracy of the updated model is heavily dependent on the location and type of discrepancy that exists and is strongly influenced by the analysts understanding of the model and selection of parameters that are used for the updating process. This paper uses simulated test data to show the sensitivity of the updated model to parameters selected in the updating process. The models presented are not intended to credit or discredit the approach but rather to provide a very unbiased view of the capabilities of the approach with its strengths and limitations. Models are intentionally developed that will span the full range of acceptable updated models to unacceptable ones. Different measured parameters are used (frequency, mode shape and response function differences) to perform the updating procedure to illustrate the improvement ( and degradation) of the finite element model depending on the analysts proper (or improper) selection of parameters for change.
Lipid and Lipoprotein Profile of Japanses Centenarians. High Prevalence of Hypo .BETA. Lipoproteinemia. (1997)

To study the relationship between lipids and longevity, we examined the level of serum lipids and apolipoproteins, and the susceptibility of low density lipoprotein (LDL) to oxidation of 45 centenarians (15 men, 30 women, mean age 101.1 +/- 1.4) living in the Tokyo metropolitan area. The average levels of total cholesterol (TC), of LDL-C of high-density lipoprotein cholesterol (HDL-C), and of apolipoproteins A1 and B were significantly lower in centenarians than in healthy middle-aged controls. The frequency of hypobeta-lipoproteinemia (apoB < 60 mg/dl) in centenarians was almost ten times as high as in controls. The time course of copper-mediated LDL, oxidation (assessed by monitoring 234 nm diene absorption (lag time)) did not significantly differ between the two groups. Analysis of LDL subfractions by non-denaturated gradient-gel electrophoresis showed a predominance of large, buoyant LDL particles (pattern A) in 75%, and a predominance of small dense LDL particles (pattern B) in 25% of centenarians. We also assessed activities of daily living (ADL) and cognitive function in the centenarians. Centenarians were divided into two groups according to the median ADL score, and were classified into five groups with a scale clinical dementia. In subjects with good ADL scores, the mean concentration of HDL-3-C was significantly higher than in those with poor ADL scores. Average levels of HDL-C were also significantly lower in subjects with moderate or severe dementia than in those with normal cognitive function. These findings suggest that centenarians have protective phenotypes of lipids and lipoproteins that protect them from atheroscierosis.
A Query Substitution-Search Result Refinement Approach for Long Query Web Searches (2009)

Long queries are widely used in current Web applications, such as literature searches, news searches, etc. However, since long queries are frequently expressed as natural language texts but not keywords, the current keywords-based search engines, like GOOGLE, perform worse with long queries than with short ones. This paper proposes a query substitution and search result refinement approach for long query Web searches. First, we retrieved several short queries related to a long query from the users’ query history. Then, we constructed the short query clusters and selected the most representative queries to substitute the original long query. However, since searching relevant short queries may ignore contexts and terms in the original long query and thus obtain diverse results and neighboring information, we compared the contexts from search results with the contexts from original long query and filtered non-relevant results. The experiments show that our approach achieves high precision for long query Web searches.
Aerobic Oxidative Heck/Dehydrogenation Reactions of Cyclohexenones: Efficient Access to meta‐Substituted Phenols (2013)

Jockeying for the (meta)position: A new dicationic palladium(II) catalyst, employing a 6,6′-dimethyl-2,2′-bipyridine ligand, promotes both the aerobic oxidative Heck coupling and dehydrogenation reactions of cyclohexenones. These reactions may be combined in a one-pot sequence to enable the straightforward synthesis of meta-substituted phenols (see scheme). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors. (2001)

S 23906-1 is a novel acronycine derivative selected on the basis of its potency in vitro. We investigated the antitumor activity of S 23906-1 against several murine transplantable tumors (C38 colon carcinoma, P388 leukemia, B16 melanoma, and Lewis lung carcinoma) and in orthotopic models of human lung (NCI-H460 and A549), ovarian (IGROV1 and NIH:OVCAR-3), and colorectal cancers (HCT116 and HT-29). Against established C38 colon carcinoma, S 23906-1 administered twice i.v. from 1.56-6.25 mg/kg markedly inhibited tumor growth. Treatment at the optimal dose (6.25 mg/kg) induced tumor regression in all of the mice. Acronycine was 16-fold less potent and only moderately active at the maximum tolerated dose, 100 mg/kg. Against other murine tumors of the former National Cancer Institute panel, S 23906-1 was either only moderately active or totally inactive. When evaluated in human orthotopic models, S 23906-1 given p.o. or i.v. demonstrated a marked antitumor activity against human carcinomas. In the two human lung cancer models, S 23906-1 increased the survival of the animals in a dose-dependent manner and induced treated versus control values of 162% (NCI-H460) and 193% (A549). Vinorelbine was less active, with treated versus control values of 119% and 174%, respectively. A significant survival benefit was also observed against the two i.p. ovarian tumors in which S 23906-1 was as active as paclitaxel, inducing 80% long-term survivors in the NIH:OVCAR-3 model. Lastly, S 23906-1 inhibited the growth of primary HT-29 and HCT116 colon tumors grafted onto the cecum as efficiently as irinotecan and eradicated the formation of lymph node, hepatic, and pulmonary metastases in the aggressive HCT116 model. The novel spectrum of activity of S 23906-1 compared with existing anticancer agents warrants further preclinical investigation.
Expression of Kv1 Potassium Channels in Mouse Hippocampal Primary Cultures: Development and Activity-Dependent Regulation (2000)

Excitability and discharge behavior of neurons depends on the highly variable expression pattern of voltage-dependent potassium (Kv) channels throughout the nervous system. To learn more about distribution, development, and activity-dependent regulation of Kv channel subunit expression in the rodent hippocampus, we studied the protein expression of members of the Kv1 subfamily in mouse hippocampus in situ and in primary cultures. In adult hippocampus, Kv1 (1-6) channel alpha-subunits were present, whereas at postnatal day 2, none of these proteins could be detected in CA1-CA3 and dentate gyrus. Kv1.1 was the first channel to be observed at postnatal day 6. The delayed postnatal expression and most of the subcellular distribution observed in hippocampal sections were mimicked by cultured hippocampal neurons in which Kv channels appeared only after 10 days in vitro. This developmental upregulation was paralleled by a dramatic increase in total K(+) current, as well as an elevated GABA release in the presence of 4-aminopyridine. Thus, the developmental profile, subcellular localization, and functionality of Kv1 channels in primary culture of hippocampus closely resembles the in situ situation. Impairing secretion by clostridial neurotoxins or blocking activity by tetrodotoxin inhibited the expression of Kv1.1, Kv1.2, and Kv1.4, whereas the other Kv1 channels still appeared. This activity-dependent depression was only observed before the initial appearance of the respective channels and lost after they had been expressed. Our data show that hippocampal neurons in culture are a convenient model to study the developmental expression and regulation of Kv1 channels. The ontogenetic regulation and the activity-dependent expression of Kv1.1, Kv1.2, and Kv1.4 indicate that neuronal activity plays a crucial role for the development of the mature Kv channel pattern in hippocampal neurons.
α2A- and α2C-Adrenergic Receptors Form Homo- and Heterodimers:  The Heterodimeric State Impairs Agonist-Promoted GRK Phosphorylation and β-Arrestin Recruitment (2006)

Dimerization of seven transmembrane-spanning receptors diversifies their pharmacologic and physiologic properties. The alpha(2)-adrenergic receptor (alpha(2)AR) subtypes A and C are both expressed on presynaptic nerves and act to inhibit norepinephrine release via negative feedback. However, in vivo and in vitro studies examining the roles of the two individual alpha(2A)- and alpha(2C)AR subtypes are not readily reconciled. We tested the hypothesis that the receptors form homo- and heterodimers and that the alpha(2A)-alpha(2C) heterodimer has unique properties. SDS-PAGE of epitope-tagged receptors revealed potential oligomers including dimers. BRET of live HEK-293 cells transfected with the subtypes fused to Rluc or YFP revealed that both subtypes form dimers and the heterodimer. A lower BRET(50) for the alpha(2A)-alpha(2C) heterodimer (0.79 +/- 0.20) compared to that of the alpha(2A) or alpha(2C) homodimer (2.331 +/- 0.44 or 3.67 +/- 0.69, respectively) suggests that when both subtypes are expressed, there is a greater likelihood that the two receptors will form the heterodimer than homodimers. Co-immunoprecipitation studies confirmed homo- and heterodimer formation. The presence of the alpha(2C)AR within the heterodimer resulted in a marked reduction in the level of GRK2-mediated alpha(2A)AR phosphorylation, which was accompanied by a qualitative attenuation of beta-arrestin recruitment. Signaling of the alpha(2A)-alpha(2C) heterodimer to the beta-arrestin-dependent activation of Akt was decreased compared to that of the alpha(2A)AR homodimer, while p44/p42 MAP kinase activation was unaffected. Thus, the alpha(2C)AR alters alpha(2A)AR signaling by forming oligomers, and these complexes, which appear to be preferred over the homodimers, should be considered a functional signaling unit in cells in which both subtypes are expressed.
Community Engagement: What’s the Problem? (2017)

Transcript of the introduction to a Seminar and Launch on 22 September 2017 at the University of Edinburgh
Today’s seminar is both a launch of the Community Engagement: A Critical Guide for Practitioners and an opportunity to consider the problematic nature of community engagement in practice.  It is not an information or motivational day on how to do community engagement; nor a decision-making or strategy-forming forum, though it may provoke some follow up activity.  Neither is it representative of any particular interests or arguments.It is intended as a forum for questioning, critique and the expression of constructive skepticism; a chance for people to come together in what we hope will be a stimulating and convivial atmosphere; an opportunity to meet friends, old and new, and allies – to feel refreshed and renewed.
Guanosine triphosphate cyclohydrolase I deficiency: a rare cause of hyperphenylalaninemia. (2000)

Tetrahydrobiopterin (BH4) deficiencies are a heterogeneous group of disorders caused by a defect in two of the three enzymes involved in its biosynthesis or in the two recycling enzymes. Except for the deficiency of dehydratase, an enzyme catalyzing a reaction in the recycling pathway, all other variants of BH4 deficiency are characterized by developmental delay, progressive neurological deterioration, hypokinesis, drooling, swallowing difficulty, truncal hypotonia, increased limb tone, myoclonus and brisk deep tendon reflexes. A deficiency of guanosine triphosphate cyclohydrolase I (GTPCH), the first enzyme in the biosynthetic pathway of BH4, is described in a 14-month-old male infant with hyperphenylalaninemia, developmental delay, hypertonia of the extremities, seizures, feeding difficulties, and vomiting. Urinary pteridine screening revealed very low levels of neopterin and biopterin which was highly suggestive of GTPCH deficiency. Low cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid concentrations, together with no detectable neopterin and decreased concentrations of biopterin and folate, agreed with the diagnosis of GTPCH deficiency. Subsequently measured neopterin and biopterin synthesis in cytokine-stimulated skin fibroblasts confirmed GTPCH deficiency, albeit indirectly. The patient showed marked improvement on a low-protein low-phenylalanine diet with neurotransmitter precursor administration. The favorable outcome in this patient clearly shows that not only newborns with elevated phenylalanine levels but also older children with neurological signs and symptoms should be screened for a BH4 deficiency in order to have maximum benefit of the treatment.
Feasibility and Short-Term Efficacy of Percutaneous Mitral Annular Reduction for the Therapy of Heart Failure-Induced Mitral Regurgitation (2003)

In this model of CHF, percutaneous placement of a mitral annular constraint device in the coronary sinus resulted in the short-term elimination or minimization of MR and was accompanied in the short term by favorable hemodynamic effects.
Simultaneous measurements of permeability and capillary pressure of thermosetting matrices in woven fabric reinforcements (1991)

Abstract A simple apparatus was designed and constructed capable of measuring the unsteady‐state permeability and the capillary pressure simultaneously in a simulated composite impregnation experiment. It was found that the Kozeny‐Carman equation used to describe the permeability of composites during impregnation adequately described experimental results for woven fabric preform up to porosity values of 0.5. Above this value, observed deviations were attributed to interfacial effects between adjacent woven fabric layers. For woven fabric preforms made of T‐300 carbon fibers, a maximum capillary pressure of 3.7 × 10 4 Pa (=5.4 psi) was observed at low porosity values. Thus, the capillary pressure may compete with other pressure sources in low pressure processes, such as the prepregging process. The woven fabric preform used in this study is observed to have a permeability similar to a unidirectional fibrous preform along the transverse direction. Furthermore, an existing modeling methodology capable of predicting permeability and capillary pressure through different preforms was found to be valid for fibrous preforms of complex orientation.
Quasi-solid Dye Sensitized Solar Cells Having Straight Ion Paths (2008)

Quasi-solid dye-sensitized solar cells (QDSCs) consisting of amylose/porous film/ionic liquid films (Am-Al/IL film) are reported. The surface of straight nanopores in the film was modified with amylose and these nanopores were filled with ionic-liquid-type electrolytes. The ionic liquid did not leak from these nanopores of the film. The photovoltaic performance of the QDSC consisting of Am-Al/IL films was almost the same as that before the solidification, despite that the film was occupied with 50% of electrochemically inactive wall. It was found that the iodine was adsorbed on the straight wall of Am–Al films and the apparent diffusion coefficient of species was almost the same as that in the parent liquid electrolyte. From these results and our previous reports, we propose QDSC structures consisting of two-carrier-density layers with low and high carrier concentrations for high-efficiency cells. A bulk area between a counter electrode and a electrode is occupied with a high-carrier-density medium , and nanopores are filled with a low-carrier-density medium . The former increases the conductivity and the latter suppresses the back electron transfer from the layer to redox species.
Effects of hematocrit and oxygen saturation level on blood spin‐lattice relaxation (2003)

In the present study blood T(1) was determined as a function of hematocrit and oxygen saturation. T(1) showed a significant linear dependency on both of these parameters. In addition, oxygen dissolved in blood plasma in hyperoxygenated blood resulted in relaxation enhancement, comparable in size to that due to the change in oxygenation state of hemoglobin. As blood T(1) is a key factor for quantification of flow with arterial spin labeling methods, the influence of T(1) variation in the physiological range of hematocrit and oxygen saturation to flow determination is discussed.
Slab-coupled optical waveguide photodiode (2008)

We report the first high-current photodiode based on the slab-coupled optical waveguide concept. The device has a large mode (5.8 times 7.6 mum) and ultra-low optical confinement (Gamma ~ 0.05%), allowing a 2-mm absorption length. The maximum photocurrent obtained was 250 mA (R = 0.8-A/W) at 1.55 mum.
HELIX-RC: An architecture-compiler co-design for automatic parallelization of irregular programs (2014)

Data dependences in sequential programs limit parallelization because extracted threads cannot run independently. Although thread-level speculation can avoid the need for precise dependence analysis, communication overheads required to synchronize actual dependences counteract the benefits of parallelization. To address these challenges, we propose a lightweight architectural enhancement co-designed with a parallelizing compiler, which together can decouple communication from thread execution. Simulations of these approaches, applied to a processor with 16 Intel Atom-like cores, show an average of 6.85× performance speedup for six SPEC CINT2000 benchmarks.
Inhibiting Histone Deacetylase 2 (HDAC2) Promotes Functional Recovery From Stroke (2017)

Our novel findings provide evidence that HDAC2 is a crucial target for functional recovery from stroke. As there are clinically available HDAC inhibitors, our findings could be directly translated into clinical research of stroke.
Inducible Costimulator Costimulates Cytotoxic Activity and IFN-γ Production in Activated Murine NK Cells (2002)

The functions of NK cells are regulated by the balance of activating and inhibitory signals. The inhibitory NK cell receptors are well understood; however, less is known about the activating signaling pathways. To explore whether a costimulatory receptor, inducible costimulator (ICOS), is involved in NK cell function, we assessed the role of ICOS in NK cell-mediated cytotoxicity and cytokine production. In addition, to determine whether ICOS contributes to the elimination of tumors in vivo, we examined the tumor growth survival of mice injected with a tumor expressing the ICOS ligand, B7RP-1. We found that ICOS was up-regulated by cytokine stimulation in murine NK cells. Consistent with ICOS expression on activated NK cells, ICOS-dependent cytotoxicity and IFN-gamma production were observed, and appeared to require signaling through the phosphoinositide 3-kinase pathway. Interestingly, ICOS-mediated stimulation allowed activated NK cells to kill more efficiently tumor cells expressing MHC class I. Furthermore, fewer metastases appeared in the liver and spleen of mice injected with the ICOS ligand-expressing tumor compared with mice bearing the parental tumor. These results indicate that NK cell functions are regulated by ICOS.
6.2 133Mpixel 60fps CMOS image sensor with 32-column shared high-speed column-parallel SAR ADCs (2015)

To realize next-generation highly realistic sensation broadcasting systems, the research and development of 8K ultrahigh-definition television (UHDTV) systems have been promoted. To realize 8K video cameras, 33Mpixel sensors [1-2] and a full-resolution camera system that uses three 33Mpixel sensors [3] have been reported. However, the weight of the camera with three sensors is over 40kg because the camera requires a large-format color-separation prism. To reduce the size of the camera, single-chip imaging is a promising approach, and a compact single-chip 8K camera that weighs only 2kg has already been developed using a color 33Mpixel CMOS image sensor [4]. However, a conventional single-chip camera has a lower image quality than a full-resolution camera because the total pixel count of the single-sensor camera is only one-third of that of the three-sensor camera, and pixel interpolation is required to configure a full-resolution image. In this paper, a 133Mpixel sensor that can be operated at 60fps to realize a full-resolution 8K single-chip camera is described. To achieve both high speed and suitable ADC resolution, 32-column multiplexing analog readout circuitry and 14b high-speed redundant successive approximation register (SAR) ADCs [5] are adopted. As a result, a full-size image with a data rate of 128.71Gb/s at 60fps has been captured.
Microbial Fuel Cells—Challenges and Applications (2006)

ADVERTISEMENT RETURN TO ISSUEPREVFEATURENEXTMicrobial Fuel Cells—Challenges and ApplicationsBruce E. Logan and John M. ReganCite this: Environ. Sci. Technol. 2006, 40, 17, 5172–5180Publication Date (Web):September 1, 2006Publication History Published online1 September 2006Published inissue 1 September 2006https://pubs.acs.org/doi/10.1021/es0627592https://doi.org/10.1021/es0627592newsACS Publications. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views26893Altmetric-Citations729LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (461 KB) Get e-Alertsclose SUBJECTS:Fuels Get e-Alerts