gebhart/patrepeval huggingface dataset:
Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device (2017)

Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 × 2 splitters was integrated in the photonic chip to split the incident light into 8 parallel imaging channels with ~3.7 mm optical delay in air between each channel. High-speed imaging (~1s/volume) of porcine eyes ex vivo and wide-field imaging (~18.0 × 14.3 mm<sup>2</sup>) of human fingers in vivo were demonstrated with the chip-based SDM-OCT system.
Single amino acid changes in the mumps virus haemagglutinin–neuraminidase and polymerase proteins are associated with neuroattenuation (2009)

It has previously been shown that three amino acid changes, one each in the fusion (F; Ala/Thr-91-->Thr), haemagglutinin-neuraminidase (HN; Ser-466-->Asn) and polymerase (L; Ile-736-->Val) proteins, are associated with attenuation of a neurovirulent clinical isolate of mumps virus (88-1961) following serial passage in vitro. Here, using full-length cDNA plasmid clones and site-directed mutagenesis, it was shown that the single amino acid change in the HN protein and to a lesser extent, the change in the L protein, resulted in neuroattenuation, as assessed in rats. The combination of both amino acid changes caused neuroattenuation of the virus to levels previously reported for the clinical isolate following attenuation in vitro. The amino acid change in the F protein, despite having a dramatic effect on protein function in vitro, was previously shown to not be involved in the observed neuroattenuation, highlighting the importance of conducting confirmatory in vivo studies. This report provides additional supporting evidence for the role of the HN protein as a virulence factor and, as far as is known, is the first report to associate an amino acid change in the L protein with mumps virus neuroattenuation.
Expressive typing (2009)

In this paper, we propose a new way for measuring key typing pressure when using off-the-shelf laptop computers. Accelerometers embedded in laptop computers to protect hard discs from sudden motion are becoming very common. This paper explores the concept of utilizing this accelerometer for sensing non-verbal aspects of key typing, such as key typing pressure. This possibility enables a wide variety of pressure-sensitive user interfaces through the use of software without requiring any additional hardware/sensors. Such software can be distributed easily to a substantial number of potential users. To confirm the feasibility of this idea, we compared typing finger velocities (obtained by high-speed camera images) with sensor data from an accelerometer embedded in a laptop computer. We then confirmed that there is a clear correlation between these two sets of data. We also investigated differences in typing pressure patterns among different users. By combining keystroke speeds and typing pressure, we found it is possible to distinguish among users. This feature can be used for security purposes such as preventing a laptop computer from being used by non-owners. We also present possible application ideas such as rich text expression, new types of user interface elements, and authentication.
Existence of the Planar [UNK] Tetrahedral Equilibrium in Solutions of Cobalt(II) Complexes (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExistence of the Planar [UNK] Tetrahedral Equilibrium in Solutions of Cobalt(II) ComplexesG. W. Everett Jr. and R. H. HolmCite this: J. Am. Chem. Soc. 1965, 87, 22, 5266–5267Publication Date (Print):November 1, 1965Publication History Published online1 May 2002Published inissue 1 November 1965https://pubs.acs.org/doi/10.1021/ja00950a061https://doi.org/10.1021/ja00950a061research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The clinical pharmacology of etoposide (1991)

Etoposide, a semisynthetic derivative of podophyllotoxin, is increasingly used to treat cancer. Etoposide is a phase-specific, cytotoxic drug acting in the late S and early G2 phases of the cell cycle. It appears to cause breaks in DNA by either an interaction with DNA-topoisomerase II or the formation of free radicals. Most studies show a biexponential decay after the intravenous (IV) administration of etoposide. The peak plasma concentrations of drug and the area under the concentration versus time curve (AUC) are linearly related to the IV dose. Considerable interpatient variability of pharmacokinetic variables exists after IV etoposide. Various metabolites of etoposide have been identified, but their detection and quantitation are disputed. Approximately 30% to 70% of an etoposide dose is excreted. The bioavailability of oral etoposide is approximately 50%, but its absorption is not linear with increasing doses within the range in clinical use. Considerable interpatient and intrapatient variability exists in the pharmacokinetics of oral etoposide. There is no evidence of etoposide accumulation after multiple consecutive doses by either the IV or oral route. The exact roles of the liver and kidney in metabolism and excretion of etoposide are uncertain. Etoposide has been shown to be a highly schedule-dependent drug in clinical studies. This, together with the phase-specific action of etoposide and its increasingly widespread use in treating cancer, makes the clinical pharmacology of this drug of great clinical importance.
Hypochlorhydria from short-term omeprazole treatment does not inhibit intestinal absorption of calcium, phosphorus, magnesium or zinc from food in humans. (1995)

These findings suggest that changing the gastric pH alone does not modify the net intestinal absorption of several minerals from food. Therefore, it is unlikely that moderate hypochlorhydria resulting from short-term omeprazole treatment substantially increases the risk for developing calcium, phosphorus, magnesium, or zinc deficiencies due to mineral malabsorption.
Introduction: Cell-Based Assays for High-Throughput Screening (2009)

Cell-based assays represent approximately half of all high-throughput screens (HTS) currently performed. Here we review the history and status of HTS, and summarize some of the challenges and benefits associated with the use of cell-based assays in HTS, drawing upon themes that will reemerge in subsequent chapters in this book. Approaches for successful experimental design and execution of cell-based HTS are introduced, including strategies for assay development, implementation of primary and secondary screens, and target identification. In doing so, we hope to provide a comprehensive review of the cell-based HTS process and an introduction to the methodologies and techniques described in this book.
Performance and Optimization of a Combustion Interface for Isotope Ratio Monitoring Gas Chromatography/Mass Spectrometry (1995)

Conditions and systems for on-line combustion of effluents from capillary gas chromatographic columns and for removal of water vapor from product streams were tested. Organic carbon in gas chromatographic peaks 15 s wide and containing up to 30 nanomoles of carbon was quantitatively converted to CO2 by tubular combustion reactors, 200 x 0.5 mm, packed with CuO or NiO. No auxiliary source of O2 was required because oxygen was supplied by metal oxides. Spontaneous degradation of CuO limited the life of CuO reactors at T > 850 degrees C. Since NiO does not spontaneously degrade, its use might be favored, but Ni-bound carbon phases form and lead to inaccurate isotopic results at T < 1050 degrees C if gas-phase O2 is not added. For all compounds tested except CH4, equivalent isotopic results are provided by CuO at 850 degrees C, NiO + O2 (gas-phase mole fraction, 10(-3)) at 1050 degrees C and NiO at 1150 degrees C. The combustion interface did not contribute additional analytical uncertainty, thus observed standard deviations of 13C/12C ratios were within a factor of 2 of shot-noise limits. For combustion and isotopic analyses of CH4, in which quantitative combustion required T approximately 950 degrees C, NiO-based systems are preferred, and precision is approximately 2 times lower than that observed for other analytes. Water must be removed from the gas stream transmitted to the mass spectrometer or else protonation of CO2 will lead to inaccuracy in isotopic analyses. Although thresholds for this effect vary between mass spectrometers, differential permeation of H2O through Nafion tubing was effective in both cases tested, but the required length of the Nafion membrane was 4 times greater for the more sensitive mass spectrometer.
Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma (1982)

The generation of murine monoclonal antibodies reactive with human leukemia and lymphoma cells has recently led to clinical trials that have begun to evaluate the use of these reagents in the treatment of various leukemias and lymphomas. Several of these studies have demonstrated that infusion of monoclonal antibody can cause the rapid and specific clearance of leukemic cells from the peripheral blood. Intravenously administered antibody also rapidly binds to bone marrow lymphoblasts, and in one instance, has resulted in the partial regression of tumor cell infiltrates in lymph nodes and skin. Unfortunately, clinically significant responses have not in general been achieved, but these clinical studies have identified specific factors that result in the development of resistance to antibody-mediated lysis in vivo. These factors include the presence of circulating antigen, antigenic modulation, reactivity of monoclonal antibody with normal cells, immune response to murine antibody, and the inefficiency of natural immune effector mechanisms. Current research is now being directed towards developing methods to circumvent each of these obstacles. Future clinical studies utilizing antibodies in vitro or with different specificity may demonstrate greater therapeutic efficacy. In addition, monoclonal antibodies can be used as carriers of other cytotoxic agents and in conjunction with other agents that will reduce the total load. Monoclonal antibodies represent new and powerful reagents that may in the near future become an additional therapeutic modality for patients with malignant disease.
X-ray Crystallographic Structure of the Norwalk Virus Capsid (1999)

Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
Paclitaxel in Breast Cancer (1998)

Paclitaxel has emerged as an important agent in the treatment of breast cancer. The efficacy and tolerability of this agent, as well as its lack of cross-resistance with anthracyclines, have spurred intensive clinical investigation worldwide. Optimization of paclitaxel dose and scheduling and evaluation of the drug in combination regimens are a central focus of investigations. Recent clinical evidence suggests that optimal dose of single-agent paclitaxel by 3-h infusion is 175 mg/m&sup2;. Trials evaluating administration schedule have not found either a 24-h or 96-h infusion to be superior to a 3-h infusion. Weekly moderate-dose paclitaxel administration is also generating much interest, given the high relative dose intensity and dose density delivered, yet very modest myelosuppression and manageable neurotoxicity observed. As first-line therapy in metastatic disease, multiple studies have documented overall response rates in the range of 30%-60%. As second-line or salvage single-agent therapy in metastatic patients, paclitaxel generally affords an overall response rate of 20%-40%, even in anthracycline-resistant patients. The novel mechanism of action and manageable toxicity of paclitaxel has led to successful incorporation into combination chemotherapy regimens. The combination of paclitaxel and doxorubicin has been the most extensively studied, with the role of this regimen continuing to evolve. Other combination regimens that appear to hold substantial promise as first-line metastatic treatment are paclitaxel with carboplatin and paclitaxel with trastuzumab (anti-HER2 antibody). The favorable results obtained in the metastatic setting have prompted phase II and phase III investigations of paclitaxel in the adjuvant and neoadjuvant settings. In the adjuvant setting, a recent phase III study has indicated that the addition of sequential paclitaxel to standard therapy affords both disease-free and overall survival benefits. Current investigations with paclitaxel will continue to optimize the role of this agent in the treatment of early- and advanced-stage breast cancer, addressing not only response rates but also survival and quality-of-life issues. The use of paclitaxel on a weekly schedule or with new therapeutic modalities, such as monoclonal antibodies, is also receiving much attention. While it is clear that paclitaxel is a very active agent in the treatment of breast cancer, it is hoped that these innovative trials will further maximize the potential of this agent in patients with breast cancer.
Insulin Resistance: Cellular and Clinical Concepts (2001)

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically, the biologic response most studied is insulin-stimulated glucose disposal, yet the precise cellular mechanism responsible is not yet known. However, the presence of insulin resistance is observed many years before the onset of clinical hyperglycemia and the diagnosis of Type 2 diabetes. Insulin resistance at this stage appears to be significantly associated with a clustering of cardiovascular risk factors predisposing the individual to accelerated cardiovascular disease. An overview of insulin resistance and the associated clinical insulin resistant state will be discussed.
Low power, low voltage conductance-mode CMOS analog neuron (2002)

Analog implementations of neural networks have been used for a wide variety of tasks especially in the area of image processing. Typically, implementations of analog neural networks have been based on the use of either current or charge as the variable of computation. This work introduces a new class of analog neural network circuits based on the concept of conductance-mode computation. In this class of circuits, accumulated weighted inputs are represented as conductances, and a conductance-mode neuron is used to apply nonlinearity and produce an output. The advantages of this class of circuits are twofold: firstly, conductance-mode computation is fast-we have developed circuits based on these principles which compute at 5-10 MHz; secondly, because conductance-mode computation requires the minimum charge necessary to compare two conductances, its energy-consumption is self-scaling depending on the difficulty of the decision to be made-we have a working prototype which consumes 166 fJ per connection. The computing precision of these circuits is high: test results on a small test structure indicate an intrinsic precision of 8-9 bits. We have developed a larger test circuit which is able to perform computation with 1056 binary-valued inputs. Initial measurements in this large test structure indicate a more limited computing precision of 6+ to 8+ bits depending on the common mode of the input signal.
The Hemopexin Domain of Matrix Metalloproteinase-9 Activates Cell Signaling and Promotes Migration of Schwann Cells by Binding to Low-Density Lipoprotein Receptor-Related Protein (2008)

Low-density lipoprotein receptor-related protein (LRP-1) is an endocytic receptor for diverse proteins, including matrix metalloproteinase-9 (MMP-9), and a cell-signaling receptor. In the peripheral nervous system (PNS), LRP-1 is robustly expressed by Schwann cells only after injury. Herein, we demonstrate that MMP-9 activates extracellular-signal-regulated kinase (ERK1/2) and Akt in Schwann cells in culture. MMP-9 also promotes Schwann cell migration. These activities require LRP-1. MMP-9-induced cell signaling and migration were blocked by inhibiting MMP-9-binding to LRP-1 with receptor-associated protein (RAP) or by LRP-1 gene silencing. The effects of MMP-9 on Schwann cell migration also were inhibited by blocking the cell-signaling response. An antibody targeting the hemopexin domain of MMP-9, which mediates the interaction with LRP-1, blocked MMP-9-induced cell signaling and migration. Furthermore, a novel glutathione-S-transferase fusion protein (MMP-9-PEX), which includes only the hemopexin domain of MMP-9, replicated the activities of intact MMP-9, activating Schwann cell signaling and migration by an LRP-1-dependent pathway. Constitutively active MEK1 promoted Schwann cell migration; in these cells, MMP-9-PEX had no further effect, indicating that ERK1/2 activation is sufficient to explain the effects of MMP-9-PEX on Schwann cell migration. Injection of MMP-9-PEX into sciatic nerves, 24 h after crush injury, robustly increased phosphorylation of ERK1/2 and Akt. This response was inhibited by RAP. MMP-9-PEX failed to activate cell signaling in uninjured nerves, consistent with the observation that Schwann cells express LRP-1 at significant levels only after nerve injury. These results establish LRP-1 as a cell-signaling receptor for MMP-9, which may be significant in regulating Schwann cell migration and physiology in PNS injury.
Deformable curve and surface finite-elements for free-form shape design (1991)

The finite element method is applied to generate primitives that build continuous deformable shapes designed to support a new free-form modeling paradigm. The primitives autonomously deform to minimize an energy functional subject to user controlled geometric constraints and loads. The approach requires less user input than conventional free-form modeling approaches because the shape can be parameterized independently of the number of degrees of freedom needed to describe the shape.Both a curve and a surface finite element are developed. The properties of these geometric primitives have been engineered to support an interactive three phase approach for defining very fair free-form shapes as found in automobiles, ship hulls and car bodies. The shape's character lines or folds and edges are defined with deformable curve segments. These character lines are then "skinned" with a deformable surface. The final shape is sculpted interactively by applying loads to the surface to control the surface shape between character lines. Shapes created with this technique enjoy the advantage that they are already meshed for further finite element analysis.
Developing hypertext documents for an international audience (1992)

Article Free Access Share on Developing hypertext documents for an international audience Author: Elizabeth S. Spragins View Profile Authors Info & Claims SIGDOC '92: Proceedings of the 10th annual international conference on Systems documentationNovember 1992 Pages 27–34https://doi.org/10.1145/147001.147005Online:01 November 1992Publication History 0citation244DownloadsMetricsTotal Citations0Total Downloads244Last 12 Months3Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A Novel Amperometric O2 Gas Sensor Based on Supported Room‐Temperature Ionic Liquid Porous Polyethylene Membrane‐Coated Electrodes (2004)

Abstract A novel solid‐state amperometric O 2 gas sensor based on the supported 1‐ethyl‐3‐methylimidazolium tetrafluoroborate (EMIBF 4 ) porous polyethylene membrane‐coated electrodes has been proposed with its characterization. By electrochemical impedance technique, the ionic conductivity of the supported EMIBF 4 membrane was estimated to be ca. 0.6 S m −1 , indicating that the supported EMIBF 4 membrane (the thickness: 50 μm) can be used as a solid state ionic conductor at room temperature. The cyclic voltammograms obtained for the one‐electron redox reaction of O 2 /O 2 −. (O 2 −. : superoxide ion) couple at high scan rates (&gt;100 mV s −1 ) showed a couple of usual redox peaks, while at low scan rates (&lt;30 mV s −1 ) S‐shaped steady‐state voltammograms similar to those obtained by rotating disk voltammetry were obtained. These results were explained on the basis of the mass transport of O 2 at the supported EMIBF 4 membrane‐coated electrode system. The transient and steady‐state reduction currents for the reduction of O 2 to O 2 −. as well as the transient oxidation current for the reoxidation of O 2 −. to O 2 , which were obtained by potential‐step chronoamperometry, could be used to measure the change of O 2 concentration in O 2 ‐N 2 mixed gas stream. The present O 2 gas sensor demonstrated a wide detection range, a high sensitivity and an excellent reproducibility.