gebhart/patrepeval huggingface dataset:
Impact of dose reductions on clinical outcomes among patients (pts) with metastatic pancreatic cancer (mPC) treated with liposomal irinotecan (nal-IRI) in oncology clinics in the United States. (2020)

665 Background: The recommended starting dose for nal-IRI is 70mg/m 2 (free base, equivalent to 80 mg/m 2 salt-based dosing). This study evaluates the impact of nal-IRI dose reductions on clinical outcomes. Methods: Using the nationwide Flatiron Health electronic health record-derived database, de-identified data were extracted and analyzed for adult mPC pts treated with nal-IRI Jan 2014-Jan 2019 and who initiated treatment at approximately the recommended dose (RD), 70mg/m2 +/- 5mg. Initial dose was derived from structured medication records, prioritizing administrations. The cumulative dose (CD) of nal-IRI over the first six weeks of treatment, the presence of dose reductions (DR) – (a decrease ≥ 7mg/m2), overall survival (OS) from treatment initiation, and duration of treatment (DoT) were assessed. Results: 257 mPC pts treated with nal-IRI (median age: 68y, IQR: 61 - 73) were identified initiating therapy at approximately the RD. 26.5% (N = 68) of pts experienced a DR during treatment. Mean 6-week CD was 175.8 mg/m 2 (SD: 77.9) among pts with no DR. For pts with DR, mean CD was 191.8 mg/m 2 (53.2). Median DoT was 6.1 wks (IQR: 2.1 – 15.3). Pts that experienced a DR had a longer median DoT: 15.1 wks (7.1 – 23.0) vs 4.3. wks (2.1 – 12.1) for pts with no DR. Overall Median OS (mOS) was 4.2 months (95% CI: 3.7 – 5.4). mOS for DR pts was 7.2 mos (95% CI: 5.5 – 9.7) and 3.7 mos (3.0 – 4.1) for pts who did not experience a DR. Conclusions: This real-world analysis suggests that reducing the dose of subsequent administrations of nal-IRI during treatment is associated with pts remaining on therapy longer, experiencing a larger CD, and a with longer OS. Additional real-world prospective studies are necessary to characterize the impact of nal-IRI dosing on clinical outcomes.
Delayed Rectifier Channels in Human Ventricular Myocytes (1995)

The conformity between the properties of IKr and those of the K+ channel in the present study strongly suggests that IKr is present in human ventricle.
Applying the acute ischemic heart disease predictive instrument. (1987)

A predictive instrument (or index) previously reported to be of value in reducing unnecessary coronary care unit admissions was tested in a randomized study. Acceptability to the physician was then measured by monitoring utilization in a subsequent nonrandomized phase and by debriefing. The predictive instrument retained predictive accuracy in the new setting with good correlation between predicted and actual risk of acute cardiac ischemia (r = 0.925). False-positive diagnosis rate decreased from 71 percent to 0.0 percent (P = .0096) in a subgroup admitted to the intermediate care unit, consistent with previously reported usefulness in low-risk patients. Acceptability was poor, however, with utilization rate of only 2.8 percent of eligible patients. Debriefing revealed low perceived usefulness. This problem will need to be addressed if widespread utilization is to occur. The criteria of predictive accuracy, usefulness, and acceptability are suggested as a standard panel for testing new predictive instruments.
Adjuvant systemic treatment of resectable breast cancer: eleven years results of a monoinstitutional chemo-hormone-immunotherapy trial. (1989)

131 patients with resectable, node-positive breast cancer were treated at the National Institute for Cancer Research of Genoa, Italy with a systemic adjuvant regimen based on 14 cycles of chemotherapy, immunostimulation with levamisole, and--for postmenopausal patients--hormone therapy with tamoxifen. The present evaluation is performed eleven years after the admission of the first patient: so far, 75 patients (57.3%) have relapsed and 52 (39.7%) have died. An analysis of prognostic factors for relapse and death shows that the number of positive axillary lymph nodes and the dimension of the primary tumor are significantly associated with survival and relapse-free survival, while age and menopausal status are not.
Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study (2012)

This study provides the first evidence that the antioxidant Pycnogenol improves endothelial function in patients with CAD by reducing oxidative stress.
Natural variation among human adenoviruses: genome sequence and annotation of human adenovirus serotype 1 (2004)

The 36,001 base pair DNA sequence of human adenovirus serotype 1 (HAdV-1) has been determined, using a 'leveraged primer sequencing strategy' to generate high quality sequences economically. This annotated genome (GenBank AF534906) confirms anticipated similarity to closely related species C (formerly subgroup), human adenoviruses HAdV-2 and -5, and near identity with earlier reports of sequences representing parts of the HAdV-1 genome. A first round of HAdV-1 sequence data acquisition used PCR amplification and sequencing primers from sequences common to the genomes of HAdV-2 and -5. The subsequent rounds of sequencing used primers derived from the newly generated data. Corroborative re-sequencing with primers selected from this HAdV-1 dataset generated sparsely tiled arrays of high quality sequencing ladders spanning both complementary strands of the HAdV-1 genome. These strategies allow for rapid and accurate low-pass sequencing of genomes. Such rapid genome determinations facilitate the development of specific probes for differentiation of family, serotype, subtype and strain (e.g. pathogen genome signatures). These will be used to monitor epidemic outbreaks of acute respiratory disease in a defined test bed by the Epidemic Outbreak Surveillance (EOS) project.
Suppression of deregulated c-MYC expression in human colon carcinoma cells by chromosome 5 transfer. (1992)

Two-thirds of sporadic colon carcinomas express elevated levels of the c-MYC protooncogene. In addition, most colon carcinoma cell lines show constitutive elevated expression (10- to 40-fold over normal) of MYC RNA and protein that is not modulated in response to a mitogenic stimulus. Indirect immunofluorescence has been used to detect c-MYC protein in such cell lines, in hybrid cells resulting from fusions of such lines with cells that regulate MYC normally, and in carcinoma cells to which a normal copy of chromosome 5 has been transferred by microcell fusion. The deregulated expression of c-MYC is suppressed by fusion with a cell that regulates MYC normally. In addition, transfer of chromosome 5 by microcell fusion results in suppression of deregulated expression. Suppressed cells are no longer tumorigenic in nude mice. Loss of the transferred chromosome results in reexpression of the tumorigenic phenotype and in constitutive elevated expression of MYC. These data indicate that function of a tumor-suppressor gene on chromosome 5 is necessary for the regulated expression of MYC in at least some colon cells. Loss of this suppressor results in deregulated MYC expression and is a necessary, but most likely not sufficient, event for the expression of the tumorigenic phenotype in a subset of colon carcinomas.
New developments in IL-6 dependent biology and therapy: where do we stand and what are the options? (1999)

Interleukin-6 (IL-6) is a four-helical protein which, on target cells, binds to a specific IL-6-receptor and two molecules of the promiscuous signal transducing protein gp130. Structure-function analysis defined three molecular contact sites between IL-6 and its receptor subunits. Using this information, competitive antagonistic proteins as well as hyperagonistic proteins were developed. Possible therapeutic applications of IL-6 antagonists are in IL-6 dependent haematological disorders (Castleman's disease, POEMS syndrome, multiple myeloma) and bone diseases (Paget's disease, osteoporosis). Designer IL-6 antagonists could suppress inflammatory activity in rheumatic and autoimmune diseases and could prevent secondary amyloidosis. IL-6 antagonists could also prove advantageous in myocardial infarction and unstable angina pectoris. IL-6 antagonists might slow down development of (mesangioproliferative) glomerulonephritis. On the other hand, hyperagonistic variants of IL-6 have a potential in ex vivo expansion of bone marrow stem cells and as thrombopoietic agents. They might also be developed into drugs to support liver regeneration in vivo and to treat stress-induced cardiac insufficiency.
Image Denoising and Inpainting with Deep Neural Networks (2012)

We present a novel approach to low-level vision problems that combines sparse coding and deep networks pre-trained with denoising auto-encoder (DA). We pro-pose an alternative training scheme that successfully adapts DA, originally de-signed for unsupervised feature learning, to the tasks of image denoising and blind inpainting. Our method’s performance in the image denoising task is comparable to that of KSVD which is a widely used sparse coding technique. More impor-tantly, in blind image inpainting task, the proposed method provides solutions to some complex problems that have not been tackled before. Specifically, we can automatically remove complex patterns like superimposed text from an image, rather than simple patterns like pixels missing at random. Moreover, the proposed method does not need the information regarding the region that requires inpaint-ing to be given a priori. Experimental results demonstrate the effectiveness of the proposed method in the tasks of image denoising and blind inpainting. We also show that our new training scheme for DA is more effective and can improve the performance of unsupervised feature learning. 1
The INTERSPEECH 2012 speaker trait challenge (2012)

LIDIAP
A Comparative Dose-Related Response of Several Key Pro- and Antiinflammatory Mediators in the Lungs of Rats, Mice, and Hamsters After Subchronic Inhalation of Carbon Black (2006)

These differences in pro- and antiinflammatory responses may contribute to the apparent species differences in inflammation and tumorigenesis.
A Selective, Ratiometric Fluorescent Sensor for Pb2+ (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Selective, Ratiometric Fluorescent Sensor for Pb2+Sandhya Deo and Hilary Arnold GodwinView Author Information Department of Chemistry, Northwestern University 2145 Sheridan Road, Evanston, Illinois 60208-3113 Cite this: J. Am. Chem. Soc. 2000, 122, 1, 174–175Publication Date (Web):December 16, 1999Publication History Received29 June 1999Published online16 December 1999Published inissue 1 January 2000https://pubs.acs.org/doi/10.1021/ja992238xhttps://doi.org/10.1021/ja992238xrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3393Altmetric-Citations301LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Fluorescence,Imaging probes,Metals,Peptides and proteins,Probes Get e-Alerts
Genomic and Proteomic Determinants of Outcome in Patients Undergoing Thoracoabdominal Aortic Aneurysm Repair (2004)

Thoracoabdominal aortic aneurysm repair, with its requisite intraoperative mesenteric ischemia-reperfusion, often results in the development of systemic inflammatory response syndrome, multiorgan dysfunction syndrome (MODS), and death. In the present study, an adverse clinical outcome following thoracoabdominal aortic aneurysm repair was identified by blood leukocyte genomic and plasma proteomic responses. Time-dependent changes in the expression of 146 genes from blood leukocytes were observed (p < 0.001). Expression of 138 genes (p < 0.001) and the concentration of seven plasma proteins discriminated between patients who developed MODS and those who did not, and many of these differences were evident even before surgery. These findings suggest that changes in blood leukocyte gene expression and plasma protein concentrations can illuminate pathophysiological processes that are subsequently associated with the clinical sequelae of systemic inflammatory response syndrome and MODS. These changes in gene expression and plasma protein concentrations are often observed before surgery, consistent with either a genetic predisposition or pre-existing inflammatory state.
LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma (2016)

Immunotherapy with immune checkpoint molecule-specific monoclonal antibody have obtained encouraging results from preclinical studies and clinical trials, which promoted us to explore whether this kind of immunotherapy could be applicable to head and neck squamous cell carcinoma (HNSCC). Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint control protein that negatively regulates T cells and immune response. Here, using the human tissue samples, we report these findings that LAG-3 is overexpressed on tumor-infiltrating lymphocytes (TILs; p < 0.001) and its overexpression correlates with the high pathological grades, lager tumor size and positive lymph node status in human primary HNSCC. Survival analysis identifies LAG-3 as a prognostic factor independent of tumor size and pathological grades for primary HNSCC patients with negative lymph node status (p = 0.014). Study in immunocompetent genetically defined HNSCC mouse model reports that LAG-3 is upregulated on CD4+ T cells, CD8+ T cells and CD4+Foxp3+ regulatory T cells (Tregs). In vivo study, administration of LAG-3-specific antibody retards tumor growth in a way associated with enhanced systemic antitumor response by potentiating the antitumor response of CD8+ T cells and decreasing the population of immunosuppressive cells. Taken together, our results offer a preclinical proof supporting the immunomodulatory effects of LAG-3 and suggest a potential therapeutic target of immunotherapy for HNSCC.
Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for Protein Kinase, Lipid Kinase and GTP-Binding Proteins (1995)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
CIDEr: Consensus-based image description evaluation (2015)

Automatically describing an image with a sentence is a long-standing challenge in computer vision and natural language processing. Due to recent progress in object detection, attribute classification, action recognition, etc., there is renewed interest in this area. However, evaluating the quality of descriptions has proven to be challenging. We propose a novel paradigm for evaluating image descriptions that uses human consensus. This paradigm consists of three main parts: a new triplet-based method of collecting human annotations to measure consensus, a new automated metric that captures consensus, and two new datasets: PASCAL-50S and ABSTRACT-50S that contain 50 sentences describing each image. Our simple metric captures human judgment of consensus better than existing metrics across sentences generated by various sources. We also evaluate five state-of-the-art image description approaches using this new protocol and provide a benchmark for future comparisons. A version of CIDEr named CIDEr-D is available as a part of MS COCO evaluation server to enable systematic evaluation and benchmarking.
Some details of developing slugs in horizontal two‐phase flow (1985)

Abstract A photographic study has been carried out to uncover the details of development of slugs in horizontal two‐phase flow. Based on the observations, it is proposed that the slugs originate as a consequence of local Kelvin‐Helmholtz instability at the wave crest, rather than the instability of the whole wave. The findings are in reasonable agreement with published results on the transition to slug flow.
Genetically-Defined Deficiency of Mannose-Binding Lectin Is Associated with Protection after Experimental Stroke in Mice and Outcome in Human Stroke (2010)

In conclusion, genetically defined MBL-deficiency is associated with a better outcome after acute stroke in mice and humans.
The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes. (1992)

A complete set of chimeras was made between the lysosomal membrane glycoprotein LEP100 and the plasma membrane-directed vesicular stomatitis virus G protein, combining a glycosylated lumenal or ectodomain, a single transmembrane domain, and a cytosolic carboxyl-terminal domain. These chimeras, the parent molecules, and a truncated form of LEP100 lacking the transmembrane and cytosolic domains were expressed in mouse L cells. Only LEP100 and chimeras that included the cytosolic 11 amino acid carboxyl terminus of LEP100 were targeted to lysosomes. The other chimeras accumulated in the plasma membrane, and truncated LEP100 was secreted. Chimeras that included the extracellular domain of vesicular stomatitis G protein and the carboxyl terminus of LEP100 were targeted to lysosomes and very rapidly degraded. Therefore, in chimera-expressing cells, virtually all the chimeric molecules were newly synthesized and still in the biosynthesis and lysosomal targeting pathways. The behavior of one of these chimeras was studied in detail. After its processing in the Golgi apparatus, the chimera entered the plasma membrane/endosome compartment and rapidly cycled between the plasma membrane and endosomes before going to lysosomes. In pulse-expression experiments, a large population of chimeric molecules was observed to appear transiently in the plasma membrane by immunofluorescence microscopy. Soon after protein synthesis was inhibited, this surface population disappeared. When lysosomal proteolysis was inhibited, chimeric molecules accumulated in lysosomes. These data suggest that the plasma membrane/early endosome compartment is on the pathway to the lysosomal membrane. This explains why mutations that block endocytosis result in the accumulation of lysosomal membrane proteins in the plasma membrane.
Optimal Resource Allocation Policies for Multi-User Backscatter Communication Systems (2016)

This paper considers a backscatter communication (BackCom) system including a reader and <i>N</i> tags, where each tag receives excitation signals transmitted by the reader and concurrently backscatters information to the reader in time-division-multiple-access (TDMA) mode. In this system, we aim to maximize the total system goodput by jointly optimizing reader transmission power, time allocation, and reflection ratio for the cases of passive and semi-passive tags. For each case, an optimization problem is formulated, which is non-convex and can be solved by being decomposed into at most <i>N</i> feasible sub-problems based on the priority of allocated reader transmission power. First, for the passive tags case, by solving the convex sub-problems sequentially and comparing their maximum total goodput, we derive the optimal resource allocation policy. Then, for the semi-passive tags case, we find a close-to-optimal solution, since each sub-problem can be reformulated as a biconvex problem, which is solved by a proposed block coordinate descent (BCD)-based optimization algorithm. Finally, simulation results demonstrate the superiority of the proposed resource allocation policies.
Role of Rel/NF‐κB transcription factors in apoptosis of human hepatocellular carcinoma cells (2002)

These results are consistent with the role of RelA/NF-kappaB activity in the regulation of apoptosis through activation of its downstream target genes and suggest that signaling pathways that control RelA/NF-kappaB activity may be important targets for novel therapeutic approaches in the treatment of human HCC.
Octreotide (1996)

A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats.1 This peptide, called somatostatin, proved to be a cyclic peptide consisting of 14 amino acids.2 Subsequent work has considerably expanded this initially simple concept of somatostatin as a peptide whose main function is the regulation of growth hormone secretion.3 Today, somatostatin is best regarded as a phylogenetically ancient, multigene family of peptides with two important bioactive products: somatostatin-14 and somatostatin-28, the latter a congener of somatostatin-14 extended at the N-terminal.3,4 Like other peptide . . .
A SOLUTION OF FILLING FOR MASONRY WALL ANALYSIS APPLIED F. E. M. (1998)

[in Japanese]
Real-time Reflective and Refractive Novel-view Synthesis (2014)

We extend novel-view image synthesis from the common diffuse and opaque image formation model to the reflective and refractive case. Our approach uses a ray tree of RGBZ images, where each node contains one RGB light path which is to be warped differently depending on the depth Z and the type of path. Core of our approach are two efficient procedures for reflective and refractive warping. Different from the diffuse and opaque case, no simple direct solution exists for general geometry. Instead, a per-pixel optimization in combination with informed initial guesses warps an HD image with reflections and refractions in 18 ms on a current mobile GPU. The key application is latency avoidance in remote rendering in particular for head-mounted displays. Other applications are single-pass stereo or multi-view, motion blur and depth-of-field rendering as well as their combinations.
Susceptibility of fluconazole-resistant clinical isolates of Candida spp. to echinocandin LY303366, itraconazole and amphotericin B (2000)

The in vitro activity of LY303366 was compared with those of itraconazole and amphotericin B against 156 fluconazole-resistant (MIC > or = 16 mg/L) clinical isolates of Candida spp. An adaptation of the NCCLS reference method was employed for determination of MICs. LY303366 was more potent than either itraconazole or amphotericin B against Candida albicans, Candida glabrata, Candida krusei and Candida tropicalis, even against isolates with itraconazole MICs > or = 1 mg/L. LY303366 was less potent in vitro against Candida parapsilosis and Candida guilliermondii isolates. LY303366 has promising antifungal activity and warrants further investigation.