gebhart/patrepeval huggingface dataset:
Identifying Children with Specific Reading Disabilities From Listening and Reading Discrepancy Scores (1990)

A method of identifying children with specific reading disabilities by identifying discrepancies between their reading and listening comprehension scores was validated with disabled and nondisabled readers in Grades 4, 5, and 6. The method is based on a modification of the reading comprehension subtest of the Peabody Individual Achievement Test (Dunn &amp; Markwardt, 1970). In this modification, even-numbered sentences are read by subjects, and odd-numbered sentences are read by the test administrator as subjects listen. The features of this test that reduce demands on working memory, thereby making it suitable for the detection of a discrepancy between reading and listening comprehension in readers with disabilities, are discussed. A significant group-by-modality interaction was obtained. Children with reading disabilities scored significantly lower on reading than on listening comprehension, while nondisabled readers scored slightly higher, but not significantly so, on reading than on listening comprehension. The appropriateness of this method as a substitute for the traditional method, which is based on the detection of a discrepancy between intelligence and reading and which has recently been proscribed in certain school districts, is discussed. Issues concerning the listening comprehension skills of disabled readers are also discussed.
Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. (1985)

Bronchoalveolar lavage fluid (BAL) was obtained from patients with adult respiratory distress syndrome (ARDS). Controls included BAL from normal subjects and from patients with sarcoidosis or pulmonary fibrosis. Neutrophil elastase measured immunologically was found in all BAL samples, but it was strikingly greater in BAL from patients with ARDS than in the BAL from normal subjects or patients with sarcoidosis. There was no significant difference in the neutrophil elastase antigen concentrations in BAL samples from patients with ARDS and those with pulmonary fibrosis. No elastolytic activity was found in either group. The alpha-1-antitrypsin and the bronchial mucus inhibitor were greater in BAL from patients with ARDS. There was a highly significant correlation between the alveolar-arterial oxygen tension difference and the neutrophil elastase concentration in BAL from the patients with ARDS. Kallikrein, prekallikrein, factor XIa-like activity, and high molecular weight kininogen antigen were found in BAL of patients with ARDS, suggesting that the kallikrein-kinin cascade may be activated in the lungs of patients with ARDS. Kallikrein-like activity in the BAL from the patients with ARDS was significantly correlated with the number of neutrophils in the BAL, the neutrophil elastase concentration, and the ability of the BAL to release elastase from cytochalasin-B-treated neutrophils. There was no correlation between these variables and C5a concentration. These studies demonstrated an association between BAL neutrophil elastase and the clinical state of patients with ARDS.
Charge-Assisted Hydrogen Bonding and Other Noncovalent Interactions in the Self-Assembly of the Organometallic Building Block [(η6-hydroquinone)Rh(P(OPh)3)2]+ with a Range of Counteranions (2006)

The synthesis and X-ray structures are reported for [(η6-hydroquinone)Rh(P(OPh)3)2]+X- (X = BF4, ClO4, SbF6, OTf, OTs, OPf), [(η6-resorcinol)Rh(P(OPh)3)2]+BF4-, and [(η6-4,4‘-biphenol)Rh(P(OPh)3)2]+BF4-. In these complexes, the −OH groups are activated by the electrophilic rhodium moiety to participate in charge-assisted hydrogen bonding to the anionic counterion. The crystal structures feature three kinds of noncovalent interactionshydrogen bonding, Coulombic attraction, and π−π stacking, which result in an intriguing array of architectures: dimeric, 1-D chain, C2 helical, and C3 helical. The nature of the charge-assisted hydrogen bonding and the resulting 3-D structure in these systems are remarkably dependent on the identity of the anion. Robust porous networks are formed rapidly (minutes or less) with [(η6-hydroquinone)Rh(P(OPh)3)2]+X- (X = BF4, ClO4) and [(η6-resorcinol)Rh(P(OPh)3)2]+BF4-. The hydrophobic pores in [(η6-hydroquinone)Rh(P(OPh)3)2]+ClO4- bind toluene reversibly. This work demonstrates that self-assembly of well-designed organometallic building blocks via charge-assisted hydrogen bonding is an effective strategy for the construction of robust porous networks. With counterions containing both oxygen and fluorine, it was found that the former is invariably the hydrogen bond acceptor, a result in agreement with atomic charge calculations. It is anticipated that self-assembly via charge-assisted hydrogen bonding is an approach applicable in many organometallic systems.
Single Molecule Sequencing of Free DNA from Maternal Plasma for Noninvasive Trisomy 21 Detection (2012)

This study shows for the first time that single molecule sequencing is an attractive and easy to use alternative for reliable noninvasive fetal aneuploidy detection in diagnostics. With this approach, previously described experimental noise associated with PCR amplification, such as GC bias, can be overcome.
Oriented Catalytic Platinum Nanoparticles on High Surface Area Strontium Titanate Nanocuboids (2011)

Platinum nanoparticles grown on SrTiO(3) nanocuboids via atomic layer deposition exhibit cube-on-cube epitaxy with the predicted Winterbottom shape, consistent with literature values of the interfacial and surface free energies. This thermodyamically stable configuration should survive the rigors of catalytic conditions to create stable, high surface area, face-selective catalysts.
In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry imaging (2015)

Sensitive and spatial exploration of the metabolism of tumors at the metabolome level is highly challenging. In this study, we developed an in situ metabolomics method based on ambient mass spectrometry imaging using air flow-assisted desorption electrospray ionization (AFADESI), which can spatially explore the alteration of global metabolites in tissues with high sensitivity. Using this method, we discovered potential histopathological diagnosis biomarkers (including lipids, amino acids, choline, peptides, and carnitine) from 52 postoperative lung cancer tissue samples and then subsequently used these biomarkers to generate images for rapid and label-free histopathological diagnosis. These biomarkers were validated with a sensitivity and a specificity of 93.5% and 100%, respectively. Moreover, a single imaging analysis of a cryosection that visualized all these biomarkers, taking tens of minutes, revealed the type and subtype of the cancer. This method could potentially be used as a molecular pathological tool for rapid clinical lung cancer diagnosis and immediate image-guided surgery.
Design of 10kW three-phase EV charger with wide output voltage range based on voltage-fed isolated PFC converter (2018)

This article presents a design of the three-phase Electric vehicle (EV) charger with a wide-output voltage range. The proposed charger is based on a voltage-fed/isolated power factor correction (PFC) converter followed by a non-isolated DC/DC converter. The three-phase PFC converter come from asymmetrical dual active bridge (ADAB) converter having zero-voltage- and zero-current-switching (ZV-ZCS) operation in the primary side so that a low-cost device such as Insulated gate bipolar junction transistor (IGBT) is available despite of a high switching frequency. Also, since the PFC converter adopts the harmonic modulation technique that can be implemented in a simple equation, all the controls for the three-phase PFC converter and the non-isolated DC/DC converter can be implemented with a simple digital controller by excluding fast current loops for input current harmonic regulation. The feasibility of the proposed charger has been verified with a 10kW prototype.
Functional Analysis of a Dominant Negative Mutant of Gαi2 (1995)

The key event in receptor-catalyzed activation of heterotrimer G proteins is binding of GTP, which leads to subunit dissociation generating GTP-bound alpha subunits and free beta gamma complexes. We have previously identified a mutation that abolished GTP binding in G alpha o (S47C) and demonstrated that the mutant retained the ability to bind beta gamma and could act in a dominant negative fashion when expressed in Xenopus oocytes (Slepak, V.Z., Quick, M.W., Aragay, A.M., Davidson, N., Lester, H.A., and Simon, M.I. (1993) J. Biol. Chem. 268, 21889-21894). In the current work, we investigated the effects of the homologous mutant of G alpha i2 (S48C) upon signaling pathways reconstituted in transiently transfected COS-7 cells. We found that expression of the G alpha i2 S48C mutant prevented stimulation of phospholipase C (PLC) beta 2 by free beta gamma subunit complexes. This effect of G alpha i S48C was not readily reversible in contrast to the inhibitory effect of wild-type G alpha i2, which could be reversed upon activation of the cotransfected muscarinic M2 receptor, presumably by release of beta gamma from the G protein heterotrimer. Coexpression of G alpha i S48C or the wild-type G alpha i2 also dramatically decreased G16-mediated stimulation of PLC by C5a in the cells transfected with cDNAs encoding C5a receptor and G alpha 16. Activation of PLC via endogenous Gq or G11 in the presence of alpha 1C adrenergic receptors was similarly attenuated by coexpression of G alpha i or G alpha i S48C. Pertussis toxin treatment of the transfected cells enhanced the inhibition of the receptor-stimulated PLC by wild-type G alpha i subunits but did not influence the effects of the dominant negative mutant. The enhancement of the wild-type G alpha i inhibitory effect by pertussis toxin can be explained by stabilization of G alpha i binding to beta gamma as a result of ADP-ribosylation, while G alpha i S48C mutant binds beta gamma irreversibly even without pertussis toxin treatment. Therefore, a feasible mechanism to rationalize the attenuation of the G alpha 16 and Gq/11-mediated activation of PLC by cotransfected G alpha i is the competition between G alpha i and G alpha 16 or Gq/11 for the beta gamma complexes, which are necessary for the G protein coupling with receptors. These experiments provide new evidence for the role of beta gamma in the integration of signals controlling phosphoinositide release through different G alpha families.
Gender differences in the expression of heat shock proteins: the effect of estrogen (2003)

The heat shock proteins (HSPs) are an important family of endogenous, protective proteins that are found in all tissues. In the heart, HSP72, the inducible form of HSP70, has been the most intensely studied. It is well established that HSP72 is induced with ischemia and is cardioprotective. Overexpression of other HSPs also is protective against cardiac injury. Recently, we observed that 17beta-estradiol increases levels of HSPs in male rat cardiac myocytes. We hypothesized that there were gender differences in HSP72 expression in the heart secondary to estrogen. To test this hypothesis, we examined cardiac levels of HSP72 by ELISA in male and female Sprague-Dawley rats. In addition, three other HSPs were assessed by Western blot (HSP27, HSP60, and HSP90). To determine whether estrogen status affected HSP72 expression in other muscles or tissues, two other muscle tissues, slow twitch muscle (soleus muscle) and fast twitch muscle (gastrocnemius muscle), were studied as well as two other organs, the kidney and liver. Because HSP72 is cardioprotective, and females are known to have less cardiovascular disease premenopause, the effects of ovariectomy were examined. We report that female Sprague-Dawley rat hearts have twice as much HSP72 as male hearts. Ovariectomy reduced the level of HSP72 in female hearts, and this could be prevented by estrogen replacement therapy. These data show that the expression of cardiac HSP72 is greater in female rats than in male rats, due to upregulation by estrogen.
Automatic video analysis and motion estimation for physical activity classification (2010)

This paper presents an automatic video analysis method for physical activity classification and measurement. A wearable device is used to capture daily life data for health monitoring. Physical activity is analyzed by using the change of surrounding scenes resulting from the motion of the wearer. Recognition of different physical activities is achieved by analyzing motion characteristics in images evaluated from a set of representative pixel pairs extracted from adjacent video frames. Ambiguous and incorrect pixel pairs are removed under the epipolar constraint from stereo images. The effectiveness of the new method is demonstrated through experiments.
Beta-adrenergic and serotonergic responsiveness of rabbit corneal epithelial cells in culture. (1983)

Rabbit corneal epithelial cell cultures were established from Dispase-treated anterior corneas. In culture medium containing cholera toxin, insulin and epidermal growth factor, these cells proliferated in vitro in the absence of any contaminating cells. Following subculture, cells retained epithelial morphology and the ability to synthesize cAMP in response to beta-adrenergic stimulation, but lacked the ability to respond to serotonergic stimulation. Retention of the beta-adrenergic system in culture serves as a functional epithelial cell marker; whereas expression of serotonergic responsiveness may be regulated by developmental or extrapithelial systems that are absent in these cell cultures.
Interactive images (2012)

Images are static and lack important depth information about the underlying 3D scenes. We introduce interactive images in the context of man-made environments wherein objects are simple and regular, share various non-local relations (e.g., coplanarity, parallelism, etc.), and are often repeated. Our interactive framework creates partial scene reconstructions based on cuboid-proxies with minimal user interaction. It subsequently allows a range of intuitive image edits mimicking real-world behavior, which are otherwise difficult to achieve. Effectively, the user simply provides high-level semantic hints, while our system ensures plausible operations by conforming to the extracted non-local relations. We demonstrate our system on a range of real-world images and validate the plausibility of the results using a user study.
Genetic Dissection of Cardiac Growth Control Pathways (2000)

Cardiac muscle cells exhibit two related but distinct modes of growth that are highly regulated during development and disease. Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle irreversibly soon after birth, following which the predominant form of growth shifts from hyperplastic to hypertrophic. Much research has focused on identifying the candidate mitogens, hypertrophic agonists, and signaling pathways that mediate these processes in isolated cells. What drives the proliferative growth of embryonic myocardium in vivo and the mechanisms by which adult cardiac myocytes hypertrophy in vivo are less clear. Efforts to answer these questions have benefited from rapid progress made in techniques to manipulate the murine genome. Complementary technologies for gain- and loss-of-function now permit a mutational analysis of these growth control pathways in vivo in the intact heart. These studies have confirmed the importance of suspected pathways, have implicated unexpected pathways as well, and have led to new paradigms for the control of cardiac growth.
Studies of the field efficacy and safety of a single‐dose Mycoplasma hyopneumoniae vaccine for pigs (2002)

The field efficacy and safety of a single‐dose Mycoplasma hyopneumoniae vaccine were evaluated in three‐to five‐week‐old pigs. Two field efficacy studies were conducted, one in England with 673 pigs, and one in Germany with 719 pigs. The pigs were injected intramuscularly with either the vaccine or saline (control) at a ratio of 2:1 and reared under commercial conditions to slaughter weight. The efficacy of the vaccine was evaluated by comparing the lung lesions associated with infection with M hyopneumoniae in the control and vaccinated animals postmortem. In both countries the vaccinated pigs had a significantly lower percentage of lung lesion scores, in England 5.7 v 10.2 per cent (P=0.0022) and in Germany 3.9 v 7.7 per cent (P=0.0056). In Germany the average daily weight gain (ADG) of the vaccinated pigs was significantly higher (639 g v 616 g) (P=0.0205). In both countries and in both the treated and control animals there was a significant negative correlation between the ADG and the lung lesion score (P=0.0001). Two safety trials were conducted, one in England and one in Germany, each with 75 pigs, and in each case 50 pigs were given the maximum batch release antigen titre of the vaccine and 25 were given saline. The safety of the vaccine was evaluated by observation for local and systemic reactions and any increases in rectal temperature. No abnormal reactions were observed in the vaccinated pigs and there was no significant difference between the mean peak rectal temperatures of the vaccinated and control pigs in either trial.
Mapping CORBA IDL to TTCN-3 based on IDL to TTCN-2 mappings (2001)

A widely used middleware for Internet based distributed systems is CORBA where interfaces are described with IDL. TTCN is used as a standardised test description language in the telecommunication area. The current version of TTCN, version 3, is among others designed to test CORBA based systems. This requires a mapping of IDL to TTCN-3 and therefore, a new mapping for TTCN-3 in contrast to the existing one for TTCN-2 gets necessary. This paper points out the new features of the TTCN-3 standard and how they can be used for an improved IDL mapping.
Prophylaxis of Experimental Rabies with the Polyriboinosinic-Polyribocytidylic Acid Complex (1971)

Journal Article Prophylaxis of Experimental Rabies with the Polyriboinosinic-Polyribocytidylic Acid Complex Get access Paul Fenje, Paul Fenje Search for other works by this author on: Oxford Academic PubMed Google Scholar Boško Postic Boško Postic Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 123, Issue 4, April 1971, Pages 426–428, https://doi.org/10.1093/infdis/123.4.426 Published: 01 April 1971 Article history Received: 20 October 1970 Revision received: 22 December 1970 Published: 01 April 1971
Embedded Bayesian networks for face recognition (2003)

The embedded Bayesian networks (EBN) introduced in this paper, are a generalization of the embedded hidden Markov models previously used for face and character recognition. An EBN is defined recursively as a hierarchical structure where the "parent" node is a Bayesian network (BN) that conditions the EBNs or the observation sequence that describes the nodes of the "child" layer. With an EBN, one can model complex N-dimensional data, avoiding the complexity of N-dimensional BNs while still preserving their flexibility and partial scale invariance. In this paper we present an application of the EBNs for face recognition and show the improvement of this approach versus the "eigenface" and the embedded HMM approaches.
Epigenetic and Genotype-specific Effects on the Stability ofde Novo Imposed Methylation Patterns in Transgenic Mice (2000)

The chloramphenicol acetyltransferase gene under the control of the late E2A promoter of adenovirus type 2 (Ad2) was introduced as transgene into the B6D2F1 mouse strain with mixed genetic background and became extensively de novo methylated. The methylation of this pAd2E2AL-CAT (7-1A) transgene was regulated in a strain-specific manner apparently depending on the site of integration. Transmission of the 7-1A transgene into an inbred DBA/2, 129/sv, or FVB/N genetic background led to a significant loss of methylation in the transgene, whereas C57BL/6, CB20, and Balb/c backgrounds favored the de novo methylation in very specific patterns. The newly established patterns of de novo methylation were transmitted to the offspring and remained stable for many generations, regardless of the heterozygosity of strain-specific DNA sequences present in these mouse strains. Segregation analyses showed a non-mendelian transmission of methylation phenotypes and suggested the involvement of dominant modifiers of methylation. The genotype-specific modifications of the transgene were followed for 11 backcross generations. These observations reflect an evolutionarily conserved mechanism directed against foreign, e.g. viral or bacterial, DNA at least in the chromosomal location of the 7-1A transgene. In seven additional mouse lines carrying the same transgene in different chromosomal locations, strain-specific alterations of methylation patterns were not observed.
White, Male & Middle Class: Explorations in Feminism & History // Review (1993)

Reviewed by Wendy Stocker Project Ploughshares Conrad Grebel College Waterloo, OntarioCatherine Hall is Reader in Cultural Studies at Polytechnic of East London. She is also a self - declared feminist, a British Marxist historian in tradition of Co mmunist Party Historians' Group that includes Christopher Hill and Edward Thompson, a - class, white woman married to a non - white man, and mother of mixed - race children. In first of ten essays which make up this book, she provides a critique of her work as an hi storian, finding significant connections between her early training in materialist, socialist his tory, her position as a working woman professional, and her family life, on one hand, and f ocus of her academic interest on other. After reading her opening essay, it is easy to understand why she would be drawn to such topics as History of Housewife, Butche r, Baker, Candlestick - maker: The Shop and Family in Industrial Revolution, and Missionary Stories: Gender and Ethnicity in England in 1830s and 1840s. From her own development as a woman and a professional, from her position in contemporary Bri tish society, she has developed a desire to understand connections between gender and cult ure, gender and class, gender and work. These topics are concern of six essa ys in book. Finally, last two essays look at the shifting and contingent relations of g ender, class, race and ethnicity between 1830s and 1860s.The essays focus on period between 1780 and 1850 in England -- a period when, as Hall describes it, - male became a dominant figure in British politi cs, business and industry. The period brought great change in role of woman in famil y structure and in society. From an active participant in a family - run and home - centred bus iness, working - and - woman became, by end of period, an id ealized figure designed by God to keep hearth and home a sacred refuge for her husband from wickedness of outside world. Hall shows, however, that as she gained in mor al stature, - woman lost ground as a contributor to family resources, so th at by end of period under examination, respectable women who needed to support thems elves had few opportunities to earn a living and little training for existing jobs. This p redicament of nineteenth - century women is brought to life in Strains of 'Firm of Wife, Children and Friends': Middle - Women and Employment in Early Nineteenth - century Eng land. As well, women were further marginalized from public life as - men bec ame more and more involved in an active political life -- a life for which women were conside red totally unsuitable.We see that to be middle - class meant something radically different for men and women. We see a move to suburbs, but men still left in morning to work in t he city, while women remained behind, separated from source of their livelihood. …