gebhart/patrepeval huggingface dataset:
An approach for implicitly detecting information needs (2003)

Searchers can have problems devising queries that accurately express their, often dynamic, information needs. In this paper we describe an adaptive approach that uses unobtrusive monitoring of interaction to help alleviate such problems and support searchers in their seeking. The approach we propose implicitly selects terms to better represent information needs, gathers evidence on potential changes in these needs, and uses this evidence to tailor the result presentation accordingly. A user evaluation of an interface implementing our approach, presented in [7], shows it can select terms that approximate current information needs and provide evidence to track changes in these needs.
Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device (2007)

The formation of spherical aggregates of cells called embryoid bodies (EBs) is an indispensable step in many protocols in which embryonic stem (ES) cells are differentiated to other cell types. Appropriate morphology and embryo size are critical for the sequential developmental stages of naturally conceived embryos. Likewise, regulating the size of EBs and the timing of their formation is crucial for controlling the differentiation of ES cells within the EB. Existing methods of formation of EBs, however, are tedious or provide heterogeneously-sized EBs. Here we describe a microfluidic system for straightforward synchronized formation of uniform-sized EBs, the size of which can be controlled by changing the cross-sectional size of microchannels in the microfluidic device. The device consists of two microchannels separated by a semi-porous polycarbonate membrane treated to be resistant to cell adhesion. ES cells introduced into the upper channel self-aggregate to form uniformly-sized EBs. The semi-porous membrane also allows subsequent treatment of the non-attached EBs with different reagents from the lower channel without the need for wash out because of the compartmentalization afforded by the membrane. This method provides a simple yet robust means to control the formation of EBs and the subsequent differentiation of ES cells in a format compatible for ES cell processing on a chip.
Effects of home-based cardiac exercise program on the exercise tolerance, serum lipid values and self-efficacy of coronary patients (2006)

Exercise-based cardiac rehabilitation improves exercise capacity and reduces cardiac risk factors. The purpose of this pilot study was to examine the effects of a home-based cardiac exercise program (HBCEP) on exercise tolerance, serum lipids, and self-efficacy in coronary heart disease patients in Turkey. Self-efficacy theory provided the framework for this study's intervention. The study design was a pre-test and post-test experimental, randomized assignment. The study included 30 participants in a home-based cardiac exercise program (HBCEP; mean age = 54.7 ± 7.8) and 30 in control (C; mean age = 52.7 ± 6.5). The Phase II cardiac exercise program included three 45-60-min sessions per week for 12 weeks, and the enhancement of self-efficacy through educational sessions and the use of goal setting, modelling, and physiological feedback strategies. Both groups were comparable in their medical regimen, exercise capacity, and other measured variables pre-intervention. At baseline and after 12 weeks, exercise capacity was evaluated by exercise testing using the Bruce Protocol, self-efficacy was measured with the Cardiac Exercise Self Efficacy Index, and serum lipid values were measured. At the completion of the 12-week exercise program, the exercise capacity (P<0.001), total cholesterol (P =0.004), triglycerides (P = 0.048), high-density lipoprotein-cholesterol (P = 0.001), low-density lipoprotein-cholesterol (P = 0.039), and self-efficacy (P<0.001) of the HBCEP Group were significantly improved compared to the control group. These results suggest that a first-time HBCEP in Turkey can be successful in having patients adhere to a prescribed exercise program and reduce risk factors. Enhanced self-efficacy may have mediated the improved behavioural outcomes.
Yeast Upf Proteins Required for RNA Surveillance Affect Global Expression of the Yeast Transcriptome (1999)

mRNAs are monitored for errors in gene expression by RNA surveillance, in which mRNAs that cannot be fully translated are degraded by the nonsense-mediated mRNA decay pathway (NMD). RNA surveillance ensures that potentially deleterious truncated proteins are seldom made. NMD pathways that promote surveillance have been found in a wide range of eukaryotes. In Saccharomyces cerevisiae, the proteins encoded by the UPF1, UPF2, and UPF3 genes catalyze steps in NMD and are required for RNA surveillance. In this report, we show that the Upf proteins are also required to control the total accumulation of a large number of mRNAs in addition to their role in RNA surveillance. High-density oligonucleotide arrays were used to monitor global changes in the yeast transcriptome caused by loss of UPF gene function. Null mutations in the UPF genes caused altered accumulation of hundreds of mRNAs. The majority were increased in abundance, but some were decreased. The same mRNAs were affected regardless of which of the three UPF gene was inactivated. The proteins encoded by UPF-dependent mRNAs were broadly distributed by function but were underrepresented in two MIPS (Munich Information Center for Protein Sequences) categories: protein synthesis and protein destination. In a UPF(+) strain, the average level of expression of UPF-dependent mRNAs was threefold lower than the average level of expression of all mRNAs in the transcriptome, suggesting that highly abundant mRNAs were underrepresented. We suggest a model for how the abundance of hundreds of mRNAs might be controlled by the Upf proteins.
Josephson-Junction Qubits and the Readout Process by Single-Electron Transistors (1998)

Several physical realizations of quantum bits have been proposed. Of those, nano-electronic devices appear most suitable for large-scale integration and potential applications. We suggest to use low-capacitance Josephson junctions, exploiting the coherence of tunneling in the superconducting state combined with the possibility to control individual charges by Coulomb blockade effects (cond-mat/9706016,cond-mat/9808067). These systems constitute quantum bits, with logical states differing by one Cooper-pair charge. Single- and two-bit operations can be performed by applying a sequence of gate voltages. The phase coherence time is sufficiently long to allow a series of these steps. In addition to the manipulation of qubits the resulting quantum state has to be read out. This can be accomplished by coupling a single-electron transistor capacitively to the qubit (cond-mat/9801125). To describe this quantum measurement process we study the time evolution of the density matrix of the coupled system. Only when a transport voltage is turned on, the transistor destroys the phase coherence of the qubit; in this case within a short time. The measurement is accomplished after a longer time scale, when the signal resolves the different quantum states. At still longer times the measurement process itself destroys the information about the initial state. We present a suitable set of system parameters, which can be realized by present-day technology.
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism (2007)

Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (Cur), such as demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumin (THC) and turmerones, modulate inflammatory signaling and cell proliferation signaling to same extent as curcumin was investigated. The results indicate that the relative potency for suppression of tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation was Cur > DMC > BDMC; thus suggesting the critical role of methoxy groups on the phenyl ring. THC, which lacks the conjugated bonds in the central seven-carbon chain, was completely inactive for suppression of the transcription factor. Turmerones also failed to inhibit TNF-induced NF-kappaB activation. The suppression of NF-kappaB activity correlated with inhibition of NF-kappaB reporter activity and with down-regulation of cyclooxygenase-2, cyclin D1 and vascular endothelial growth factor, all regulated by NF-kappaB. In contrast to NF-kappaB activity, the suppression of proliferation of various tumor cell lines by Cur, DMC and BDMC was found to be comparable; indicating the methoxy groups play minimum role in the growth-modulatory effects of curcumin. THC and turmerones were also found to be active in suppression of cell growth but to a much lesser extent than curcumin, DMC and BDMC. Whether suppression of NF-kappaB or cell proliferation, no relationship of any of the curcuminoid was found with reactive oxygen species (ROS) production. Overall, our results demonstrated that different analogs of curcumin present in turmeric exhibit variable anti-inflammatory and anti-proliferative activities, which do not correlate with their ability to modulate the ROS status.
Composition control of Hf1−xSixO2 films deposited on Si by chemical-vapor deposition using amide precursors (2002)

Hafnium silicate (Hf1−xSixO2) films were deposited by metalorganic chemical-vapor deposition with composition x ranging from 0 to 1 using amide precursors in an organic solvent. The liquid precursors, tetrakis(diethylamido)hafnium, Hf[N(C2H5)2]4, and tetrakis(dimethylamido)silicon, Si[N(CH3)2]4, are compatible when mixed in solution, have high elemental purity, and exhibit a low halogen content. Thin oxide films were deposited with these precursors over a range of wafer temperatures from 400 to 600 °C with very low carbon and nitrogen incorporation. Control of the film composition is attained by changing the ratio of silicon concentration to hafnium concentration in the precursor solution for specific deposition conditions. Composition and growth rate are reported as a function of process condition. Interfacial layers of less than 10 Å were observed by high-resolution transmission electron microscopy.
Mathematics goes palatable for the people (1992)

These two books are about serious mathematics and both can be read and enjoyed by the educated layperson. Literature of this kind is still a comparative rarity since mathematicians and non-mathematicians do not, as a rule, understand each other very well; they speak quite different languages.
X-PLOR Version 3.1: A System for X-ray Crystallography and NMR (1992)

X-PLOR is a highly sophisticated computer program that provides an interface between theoretical foundations and experimental data in structural biology, with specific emphasis on X-ray crystallography and nuclear magnetic resonance spectroscopy in solution of large biological macro-molecules. This manual to X-PLOR Version 3.1 presents the theoretical background, syntax, and function of the program and also provides a comprehensive list of references and sample input files with comments. It is intended primarily for researchers and students in the fields of computational chemistry, structural biology, and computational molecular biology.
Proton transport in polybenzimidazole blended with H3PO4 or H2SO4 (2002)

Abstract Proton transport in H 3 PO 4 ‐ and H 2 SO 4 ‐blended polybenzimidazoles (PBIs) has been studied with both temperature‐ and pressure‐dependent dielectric spectroscopy. The influences of the acid concentration and temperature on the relative conductance and activation volume are discussed. An Arrhenius relation is used to model the temperature‐dependent conductivity at a constant acid content. The logarithm of the relative conductance for PBI blended with H 3 PO 4 decreases linearly with increasing pressure. As the temperature increases, the activation volume becomes smaller for PBI blended with H 3 PO 4 . It is proposed that proton transport in acid‐blended PBI is mainly controlled by proton hopping and diffusion rather than a mechanism mediated by the segmental motions in the polymer. The conductivities of PBIs blended with H 3 PO 4 and H 2 SO 4 are compared. At a 1.45 molar acid doping concentration, the former has the higher conductivity. With water, the conductivity of H 3 PO 4 ‐blended PBI increases significantly. © 2002 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 40: 663–669, 2002; DOI 10.1002/polb.10132
Miniature dielectric-loaded personal telephone antennas with low SAR (2002)

The short history of the cellular telephone have witnessed astonishing advances in the state of the art of personal telephone handset design. However, there is an increase in the public anxiety about possible health risks of using personal telephones, and it is becoming increasingly important to produce handsets which completely meet the international specific energy-absorption rate (SAR) regulations. The most common antenna topologies used on handsets today are basically monopole or monopole derived structures. One significant limitation of monopole and some monopole derived antennas concerns their lack of polarisation diversity. Personal telephone handsets are often used inside buildings and in urban environments where scattering of the signal from vertically and horizontally disposed surfaces promote mixing of polarisations which changes spatially. Moreover the orientation of the handset with respect to the dominant polarisation plane of the base-station antenna can be entirely arbitrary. Efforts have been made to propose "figure of merit" measures for mobile telephone antennas in cluttered urban environments. This article shows that antennas with high diversity have superior communications performance.
Three-Dimensional Radiobiologic Dosimetry: Application of Radiobiologic Modeling to Patient-Specific 3-Dimensional Imaging-Based Internal Dosimetry (2007)

The analysis demonstrates the impact of radiobiologic modeling on response prediction. The 57% reduction in the equivalent dose value for the tumor reflects a high level of dose nonuniformity in the tumor and a corresponding reduced likelihood of achieving a tumor response. Such analyses are expected to be useful in treatment planning for radionuclide therapy.
Volatile Compounds from Strawberry Foliage and Flowers (1993)

Headspace compounds were isolated from detached strawberry foliage by using both air and nitrogen as entrainment gases and trapping on the porous polymer Tenax. Compounds were eluted from traps with hexane, analyzed by GC and GC-MS, and identified by comparison with authentic standards. The profile of volatiles entrained with nitrogen differed considerably from that obtained with air; the former yielded more aliphatic alcohols, esters, and aromatics and the latter yielded greater quantities of terpene hydrocarbons. Air was selected for subsequent experiments including entrainment of flower headspace volatiles which contained aromatic compounds not found in foliage. The developmental stage of the plants also affected the types and quantities of compounds obtained. Considerably more headspace volatiles were isolated from foliage of flowering plants in early Spring than were obtained during later stages of plant development. Removal of the fruit which represented a metabolic sink for the plants did not significantly alter emission of foliage volatiles compared to that from controls.
Endocrine secretion of alpha-amylase by the pancreas (1981)

The effect of the gastrointestinal hormone, cholecystokinin-pancreozymin (CCK-PZ), on the flux of alpha-amylase across the basolateral surface of the pancreas into interstitial fluid was measured by following its appearance in the medium bathing whole rabbit pancreas in organ culture. CCK-PZ increased the rate of amylase release by about an order of magnitude for the maximum applied dose. The response was only observed at concentrations of CCK-PZ that were supramaximal for ductal enzyme secretion (320 pmol/l to 10 nmol/l). Over this range, amylase secretion into the bath varied widely with dose, whereas that into the duct remained relatively unchanged. These observations, in conjunction with others, suggest that the acinar cell, and not the duct system, is the direct source of this amylase and that there is a natural secretion of digestive enzyme from the acinar cell in the endocrine direction that is augmented by CCK-PZ or a homologous peptide.
Intracellular Gastrin in Human Gastrointestinal Tumor Cells (1991)

Flow cytometry and immunohistochemical analyses of the human gastric adenocarcinoma cell line MKN45G identified an intracellular peptide recognized by an anti-gastrin-17 (G17) antiserum but not by an anti-cholecystokinin-specific antiserum. Staining was not associated with the parental line MKN45, of which MKN45G is a clonal variant. The MKN45G cell line had elevated in vitro growth in serum-free medium in which the proliferation of MKN45G cells but not MKN45 cells was reduced to 58% of the control value by treatment with a rabbit anti-G17 antiserum. This inhibition of proliferation was reversed by preabsorbing the antiserum with excess G17. Disaggregated primary human gastric and colorectal tumors were screened for gastrin immunoreactivity by flow cytometry, and 6 of 28 colorectal and 8 of 22 gastric tumors had greater than 20% positively staining cells.
Advanced antenna systems for WCDMA: link and system level results (2002)

This contribution presents some link and system level simulation results obtained by a WCDMA base station equipped with an adaptive antenna system. The results show that the performance gain obtained by an advanced antenna system could be substantial compared to an ordinary sector covering system. The link simulations show that for a given SIR target in a single cell system, the capacity is increased considerably compared to a conventional single sector covering antenna system. It is also shown that the difference between the different adaptive antenna algorithms is marginal. The system level simulations have shown that the capacity performance is basically proportional to the number of orthogonal beams used in the base station. In cases where the conventional three sector reference system is not truly interference limited, the performance gain can be even higher. The system simulations have also shown that using more beam positions than those defining the set of orthogonal fixed beams slightly improves the performance. However the number of beam positions can be kept relatively small, in the order of twice the number of orthogonal beams, without significant loss.
Propargyl Claisen rearrangement: allene synthesis and beyond (2012)

The propargyl Claisen rearrangement is a known protocol to gain access to functionalized allenes through the [3,3]-sigmatropic transformation of propargyl vinyl ethers. The correct use of appropriate propargyl vinyl ethers as starting materials coupled with suitable reaction conditions can aid in the development of new domino methodologies in which the allenes are valuable intermediates in route to a wide range of important classes of organic compounds.
IBM's Statistical Question Answering System - TREC-11 (2006)

In this paper, we document our efforts to extend our statistical question answering system for TREC-11. We incorporated a web search feature, and novel extensions of statistical machine translation as well as extracting lexical patterns for exact answers from a supervised corpus. Without modification to our base set of thirty-one categories, we were able to achieve a confidence weighted score of 0.455 and an accuracy of 29%. We improved our model on selecting exact answers by insisting on exact answers in the training corpus and this resulted in a 7% gain on TREC-11 but a much larger gain of 46% on TREC-10.
GaAs free-standing quantum-size wires (1993)

Ultrathin GaAs wires as thin as 15–40 nm and about 2 μm long have been grown on a GaAs substrate by metal-organic vapor-phase epitaxy. The wires, which consist of whiskers, are grown between 380 and 550 °C using trimethylgallium and arsine (AsH3) as source materials. It is found that the wire growth direction is parallel to the [111] arsenic dangling-bond direction and can be perfectly controlled by the crystallographic orientation of the GaAs substrate surface. From transmission electron microscopic analysis it is revealed that the crystal structure of the wire coincides with the zinc-blende type for the growth temperature range of 460–500 °C, but it changes to the wurtzite type at 420 °C and temperatures higher than 500 °C. It is also found that the wires have a twin-type structure around the [111] growth axis for zinc blende and [0001] growth axis for wurtzite. Photoluminescence study of these wires shows that the luminescence peak energy shifts to a higher energy as the wire width decreases from 100 to about 35 nm. In terms of luminescence polarization it is confirmed that the luminescence intensity parallel to the wires is four times greater than that perpendicular to the wires. These results clearly indicate the quantum-size effect of carriers confined in the wire. As a preliminary application to devices, a p-n junction has been formed along the GaAs wire. Light emission by current injection to the p-n junction wires has been observed in continuous operation at room temperature.
Effect of Humidity on Nanoparticle-Based Chemiresistors: A Comparison between Synthetic and Real-World Samples (2011)

Chemiresistors based on metal monolayer-capped nanoparticles (MCNPs) are promising candidates for fast, inexpensive, and portable tracing of (bio)chemical species in the gas phase. However, the sensitivity of such sensors to humidity is problematic, limiting their reliable and reproducible application in real-world environmental conditions. In this work, we employed a compensation method to explore the effect of humidity on a single MCNP chemiresistor as well as on an array of MCNP sensors used to analyze either synthetic or real-world samples. We show that an array of MCNP chemiresistors is able to precisely detect and estimate subtle concentrations of (mixtures of) volatile organic compounds (VOCs) under variable backgrounds of 2-83% relative humidity (RH) only after humidity compensation. Humidity effects were also tested in two clinical trials aimed at detecting prostate cancer and breast cancer through exhaled breath analysis. Analysis of the results showed improved cancer detection capabilities as a result of RH compensation, though less substantial than the impact of RH compensation on synthetic samples. This outcome is attributed to one - or a combination - of the following effects: (i) the RH variance was smaller in the breath samples than that in the synthetic samples; (ii) the VOC composition in the breath samples is less controlled than the synthetic samples; and (iii) the responses to small polar VOCs and water are not necessarily additive in breath samples. Ultimately, the results presented here could assist the development of a cost-effective, low-power method for widespread detection of VOCs in real-world applications, such as breath analysis, as well as for environmental, security, and food applications.
Recent Advances in Chemical Modification of Peptide Nucleic Acids (2012)

Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification.