gebhart/patrepeval huggingface dataset:
RELATIONSHIP BETWEEN DRIVING BEHAVIOUR AND TRAFFIC ACCIDENTS - ACCIDENT DATA RECORDER AND DRIVING MONITOR RECORDER (1998)

A field trial has been carried out using a set of automatic recording system, Driving Monitoring Recorder (DMR) and Accident Data Recorder (ADR) installed on 20 vehicles in a fleet of cars in Tokyo area, in order to assess the implications in driving behavior and accidents. The 38 subjects who drive the 20 vehicles were monitored during driving by the DMR for one year. Simultaneously, the data in pre- and post accident were recorded by ADR whenever accidents occurred. In addition, the drivers were examined by a driving aptitude test. The data by DMR are analyzed focusing on fluency of occurrence of emergency brake operation and/or rapid start performance as representing driving behavior as a trial. The 23 accident cases including cross accident, rear-end accident, turning accident, are collected by ADR for one year. The accident data are analyzed focusing on environmental condition in pre-accident stage and driving behavior. Relationships between driving behavior and accident are proposed as results of data analysis. In particular, the accident mechanisms of specific accidents, in which the subject ranked careless driver involved can be explained in terms of driving behavior, which is determined by his cognition and/or judgment when he is facing specific environmental situations. A set of the automatic recording systems offer very clear benefits to study traffic accident mechanism in particular on the manner of driving immediately before accident, and they will provide hitherto unavailable information in the field of road safety. For the covering abstract see IRRD E102514.
Antiproliferative Activity of a Hybrid Protein Between Interferon-γ and Tumor Necrosis Factor-β (1988)

A hybrid protein between interferon-gamma and tumor necrosis factor-beta was made by ligating the respective genes and expressing the fused genes under the control of the trp promoter in Escherichia coli. The antiproliferative activity of the hybrid protein in vitro was greatly increased compared with either interferon-gamma or tumor necrosis factor-beta alone, and both antiviral activity and cytotoxic effect were retained in the hybrid protein. The hybrid protein may have potential clinical application.
Influence of fat on liver T1 measurements using modified Look–Locker inversion recovery (MOLLI) methods at 3T (2016)

At 3T, MOLLI T1 values are affected by HLC, substantially changing MOLLI T1 in a clinically relevant range of fat content. J. Magn. Reson. Imaging 2016;44:105-111.
Differential recruitment of CD63 and Rab7-interacting-lysosomal-protein to phagosomes containing Mycobacterium tuberculosis in macrophages (2009)

M.tb is an intracellular pathogen which survives within the phagosomes of host macrophages by inhibiting their fusion with lysosomes. Here, it has been demonstrated that a lysosomal glycoprotein, CD63, is recruited to the majority of M.tb phagosomes, while RILP shows limited localization. This is consistent with the author's findings that CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7. These results suggest that M.tb phagosomes selectively fuse with endosomes and lysosomes to escape killing activity while acquiring nutrients.
Expression of Amphiregulin, a Novel Gene of the Epidermal Growth Factor Family, in Human Gastric Carcinomas (1993)

The expression of mRNA for amphiregulin (AR), a novel gene of the epidermal growth factor family, was examined in 8 human gastric carcinoma cell lines and 32 gastric carcinoma tissues as well as corresponding normal mucosa. Of the 8 gastric carcinoma cell lines, 7 expressed 1.4 kb AR mRNA at various levels. The expression of AR mRNA by TMK-1 and MKN-28 cells was increased by treatment with epidermal growth factor or transforming growth factor a. In surgical cases, all the gastric carcinoma tissues and their adjacent normal mucosa expressed AR mRNA. Interestingly, 20 (62.5%) out of 32 tumors expressed AR mRNA at higher levels than their corresponding normal mucosas (tumor/normal > or = 1.2). No obvious correlation was observed between the AR mRNA levels and the histological types or tumor staging of gastric carcinoma. Immunohistochemically, AR protein was localized to the cytoplasm and/or nucleus in tumor cells. These results suggest that AR produced by tumor cells may be involved in the pathogenesis and/or progression of human gastric carcinoma.
Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo. (1996)

Abrogation of IL-1 activity, in combination with other systemic therapies may prove useful in the treatment of melanoma.
Assessment of percent cholesterol absorption in humans with stable isotopes (1993)

Dietary cholesterol restriction is a general recommendation for the medical community and emphasizes the importance of intestinal cholesterol absorption and metabolism in humans. However, several methods that may accurately quantify cholesterol absorption utilize radioactive isotopes that are undesirable for younger individuals, women, children, and normal subjects. To eliminate this hazard, we have developed a procedure for measurement of percent cholesterol absorption, based on that of Zilversmit (1972. Proc. Soc. Exp. Med. Biol. 140: 862-865), using stable nonradioactive isotopic tracers of cholesterol. [26,26,26,27,27,27-2H]cholesterol (30 mg) was administered orally and [23,24,25,26,27-13C]cholesterol (15 mg) was administered intravenously on day 0 and percent cholesterol absorption was calculated as the plasma ratio of oral/intravenous isotopic tracer on day 3 as determined by gas chromatography-mass spectrometry with selected ion monitoring. Tracer cholesterol given orally peaked in plasma on day 2 and then slowly declined in parallel with the intravenous tracer. Cholesterol absorption in 16 healthy subjects (on no medication and not ingesting alcohol) consuming a Step One Diet was 53.5% +/- 8.5 SD%. Five subjects underwent repeat testing after 4-6 weeks with excellent replication (SD of difference between tests = 2.8%). No differences in the metabolism of [13C5]cholesterol, [2H6]cholesterol, and [14C]cholesterol were observed. The use of stable isotopes for the study of percent cholesterol absorption is precise and safe, allowing repeated measurements in normal individuals and thus facilitating clinical investigation of this key component of human cholesterol metabolism.
Verification of Analog/Mixed-Signal Circuits Using Symbolic Methods (2008)

This paper presents two symbolic model checking algorithms for the verification of analog/mixed-signal circuits. The first model checker utilizes binary decision diagrams while the second is a bounded model checker that uses a satisfiability modulo theory solver. Both methods have been implemented, and preliminary results are promising.
Rheological Behavior of Shear-Responsive Metallo-Supramolecular Gels (2004)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTRheological Behavior of Shear-Responsive Metallo-Supramolecular GelsYiqiang Zhao, J. Benjamin Beck, Stuart J. Rowan, and Alex M. JamiesonView Author Information Department of Macromolecular Science & Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7202 Cite this: Macromolecules 2004, 37, 10, 3529–3531Publication Date (Web):April 15, 2004Publication History Received12 February 2004Revised16 March 2004Published online15 April 2004Published inissue 1 May 2004https://pubs.acs.org/doi/10.1021/ma0497005https://doi.org/10.1021/ma0497005rapid-communicationACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views1898Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Gels,Ions,Nucleic acid structure,Polymers,Stress Get e-Alerts
Efficient Synthesis of Carbon Nanotube–Nanoparticle Hybrids (2006)

Abstract A simple and versatile approach has been developed to synthesize different carbon nanotube (CNT)–nanoparticle hybrid materials. The strategy is based on the nondestructive (noncovalent) functionalization of pristine CNTs and the subsequent in situ synthesis of a variety of different nanoparticles, including metal, semiconductor, and insulator particles, on the modified CNTs. This strategy has been demonstrated here with Pt, CdS, and silica nanoparticles. It is believe that this technique will provide a simple and convenient route to efficiently assemble a wide variety of nanoscale particles/clusters on the surfaces of CNTs, and will enable the construction of nanoscale heterostructures with novel functionalities in nanotechnology.
Modeling of a Deepwater Turbidite Reservoir Conditional to Seismic Data Using Principal Component Analysis and Multiple-Point Geostatistics (2003)

Summary A new geostatistical approach, known as multiple-point statistics (MPS) simulation, recently has been proposed to generate 3D depositional facies models that integrate both large-scale information derived from seismic data and fine-scale information derived from well logs, cores, and analog studies. In this paper, the practicality, flexibility, and CPU advantage of this new approach are demonstrated through the modeling of an actual deepwater turbidite reservoir. First, based on well-log interpretation and a global geological understanding of the reservoir architecture, a training image depicting sinuous sand bodies is generated using a nonconditional object-based simulation algorithm. Then, disconnected sand bodies are interpreted from seismic amplitude data using a principal component cluster analysis technique, while a sand probability cube is generated using a principal component proximity transform of the same seismic. Multiple-point geostatistics allows simulating multiple realizations of channel bodies similar to the training image, constrained to the local sand probabilities, partially interpreted sand bodies, and well-log data. As illustrated in this paper, to account for uncertainty about the geometry of the sand bodies, different training images associated with alternative conceptual models proposed by the geologists can be considered.
Invasive behaviour of human gliomas is mediated by interindividually different integrin patterns. (1998)

Although invasion of human gliomas is mediated by integrins, due to the heterogeneity of its dependency on different integrins this approach seems not to be appropriate to sufficiently alter glioma invasion in a therapeutical neuro-oncological setting.
Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease (1983)

Previous studies showed that patients with neoplasms of various types and origins have abnormally high concentration of DNA in their serum. The current work compares circulating DNA levels in patients with benign or malignant disease of the gastrointestinal tract and determines the diagnostic value of such measurements. DNA was quantitated by radioimmunoassay capable of detecting 25 ng/ml, and as a simple and noninvasive test, it could be a useful addition to other diagnostic procedures. The GI tract was chosen because it affords a comparison of benign, precancerous, and malignant lesions of the same organ. Of the 386 patients studied prospectively, 48% had benign disease and mean DNA levels (+/- SE) of 118 +/- 14 ng/ml, whereas 52% had malignant disease and 412 +/- 63 ng DNA/ml. The difference was statistically significant (P less than 0.001). The DNA assay showed the highest sensitivity for pancreas carcinoma: 90% of the patients had DNA levels above 100 ng/ml, chosen as the upper normal limit. Simultaneous measurements of both DNA and carcinoembryonic antigen (CEA) resulted in increased sensitivity and specificity, even when either marker alone had low sensitivity (gastric carcinoma). The results indicate that serum DNA concentration is markedly elevated in malignancy, and moderately elevated in benign disease, as compared with normal controls. These findings may have diagnostic and prognostic value.
Physical mapping of the Mycopiasma pneumoniae genome (1988)

In order to study the genome organization of Mycoplasma pneumoniae a cosmid library of M. pneumoniae DNA was established using a newly designed cosmid vector (pcosRW2). From this library 32 overlapping clones were isolated covering a contiguous 720 kbp DNA segment representing about 90% of the genome assuming a genome size of about 800 kbp.
A high throughput controller for a 256-channel cardiac potential overlapping system (2002)

Describes an embedded controller board for a data acquisition system used in biomedical research. The board is essentially a 32 Mbyte memory buffer, accessible from four ports in round-robin fashion. Special FPGA-based sequencers managed by a local microcontroller provide a throughput of 2.5 Mbyte/s per port and automatically perform all low-level acquisition tasks: initiating A/D conversions, transferring A/D data to a buffer (queue) in memory and then transmitting the data to a host computer. The controller is presently used in a cardiac potential mapping system where it enables simultaneous acquisition of 256 channels at 4000 Hz per channel at a resolution of 12 bits per sample.
Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats (2006)

When the unbound GKA compound level is greater than the in vitro enzyme potency there was significant blood glucose lowering in vivo. This latter relationship was upheld in non-diabetic Wistar rats orally dosed with a GKA. The robust and predictive nature of the PK-PD relationship for GKAs may prove of value in testing these agents in early human clinical studies.
Improving quality and scalability of webRTC video collaboration applications (2018)

Remote collaboration is common nowadays in conferencing, tele-health and remote teaching applications. To support these interactive use cases, Real-Time Communication (RTC) solutions, as the open-source WebRTC framework, are generally used. WebRTC is peer-to-peer by design, which entails that each sending peer needs to encode a separate, independent stream for each receiving peer in the remote session. This approach is therefore expensive in terms of number of encoders and not able to scale well for a large number of users. To overcome this issue, a WebRTC-compliant framework is proposed in this paper, where only a limited number of encoders are used at sender-side. Consequently, each encoder can transmit to a multitude of receivers at the same time. The conference controller, a centralized Selective Forwarding Unit (SFU), dynamically forwards the most suitable stream to each of the receivers, based on their bandwidth conditions. Moreover, the controller dynamically recomputes the encoding bitrates of the sender, to follow the long-term bandwidth variations of the receivers and increase the delivered video quality. The benefits of this framework are showcased using a demo implemented using the Jitsi-Videobridge software, a WebRTC SFU, for the controller and the Chrome browser for the peers. Particularly, we demonstrate how our framework can improve the received video quality up to 15% compared to an approach where the encoding bitrates are static and do not change over time.
Tazarotene-first of a new generation of receptor-selective retinoids (1996)

Tazarotene is a topically applied retinoid that targets the skin, the site of the fundamental defect(s) in psoriasis, modulating the major causes of the disease and achieving sustained efficacy. In vitro, binding of tazarotenic acid has been demonstrated to retinoic acid receptors (RARs), the probable molecular target of retinoid action in adult human skin, but not to retinoid X receptors (RXRs). In gene activation assays, tazarotene is selective for the RAR beta and RAR gamma subtypes. This selectivity could theoretically limit undesirable effects at the receptor level. In vitro, animal and clinical evidence reveals that topical tazarotene modulates all three pathogenic factors in psoriasis: abnormal keratinocyte differentiation, hyperproliferation, and increased expression of inflammatory markers. Tazarotene is minimally absorbed systemically after topical administration. Tazarotene is rapidly metabolized by esterase metabolism to its active free-acid form, tazarotenic acid, which has a relatively short elimination half-life (1-2 h). The pharmacokinetic profile of tazarotenic acid is predictable, with no significant accumulation. In preclinical toxicity studies, high topical doses produced only reversible topical irritation, and lower doses were well tolerated. Topical doses were neither carcinogenic nor teratogenic, had no effect on fertility or general reproduction, and were not phototoxic, sensitizing, or photoallergenic. The pharmacological selectivity of tazarotene and limited systemic exposure result in minimal systemic effects, while the lesser cytotoxic effects (relative to other retinoids) result in reduced local effects.
Erinacerins, Novel Glioma Inhibitors from Hericium erinaceus, Induce Apoptosis of U87 Cells through Bax/Capase-2 Pathway (2020)

Erinacerin O and Erinacerin P are novel compounds obtained from Hericium erinaceus and Erinacerin P could be a potential novel glioma inhibitor.
Knob-positive and knob-negative Plasmodium falciparum differ in expression of a strain-specific malarial antigen on the surface of infected erythrocytes. (1984)

We have investigated the expression of a strain-specific malarial antigen on the surface of erythrocytes infected with knobless (K-) variants of knob-positive (K+) strains of Plasmodium falciparum. Aotus blood infected with K+ or K- parasites derived from two independent geographical isolates (Malayan camp and Santa Lucia) was surface iodinated by the lactoperoxidase method. Infected and uninfected erythrocytes were then separated by a new procedure involving equilibrium density sedimentation on a Percoll gradient containing sorbitol. Strain-specific antigens were readily identified on the surface of erythrocytes infected with either of the K+ strains by their characteristic size and detergent solubility. These proteins were not detected on the surface of erythrocytes infected with either of the K- variants nor on uninfected erythrocytes isolated from K+- or K- -infected blood. These results are consistent with a role for the strain-specific surface antigen in cytoadherence of P. falciparum-infected erythrocytes. Our findings represent the second biochemical difference (with the knob-associated histidine-rich protein) between K+ and K- P. falciparum.
Photoalignment of Liquid-Crystal Systems (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoalignment of Liquid-Crystal SystemsKunihiro IchimuraView Author Information Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan Cite this: Chem. Rev. 2000, 100, 5, 1847–1874Publication Date (Web):April 15, 2000Publication History Received23 June 1999Published online15 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/cr980079ehttps://doi.org/10.1021/cr980079eresearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views12233Altmetric-Citations1322LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Azobenzene,Chromatography,Light,Polymers,Thin films Get e-Alerts
Liquid Ink Jet Printing with MOD Inks for Hybrid Microcircuits (1987)

Application of the computer-controlled impulse ink jet with liquid metallo-organic decomposition (MOD) inks is demonstrated to be feasible in printing hybrid microcircuits. The advantages of ink jet printing over conventional screen printing are discussed. The hardware and software of the ink jet printing system have been developed. The MOD ink system suitable for the ink jet has been studied. Printing experiments with the ink jet have been conducted during the research. A theoretical model has been derived relating the ink jet flow rate to the primary spray control parameters. The ink jet system with silver neodecanoate MOD ink has been applied to metallize the grid pattern of silicon solar cells.
Perspectives and Challenges of Emerging Single‐Molecule DNA Sequencing Technologies (2009)

The growing demand for analysis of the genomes of many species and cancers, for understanding the role of genetic variation among individuals in disease, and with the ultimate goal of deciphering individual human genomes has led to the development of non-Sanger reaction-based technologies towards rapid and inexpensive DNA sequencing. Recent advancements in new DNA sequencing technologies are changing the scientific horizon by dramatically accelerating biological and biomedical research and promising an era of personalized medicine for improved human health. Two single-molecule sequencing technologies based on fluorescence detection are already in a working state. The newly launched and emerging single-molecule DNA sequencing approaches are reviewed here. The current challenges of these technologies and potential methods of overcoming these challenges are critically discussed. Further research and development of single-molecule sequencing will allow researchers to gather nearly error-free genomic data in a timely and inexpensive manner.