gebhart/patrepeval huggingface dataset:
Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men (2002)

T is now well accepted that serum testosterone (T) levels decline progressively with aging in men (1‐5). This decline is associated with alterations in body composition; diminished energy, muscle strength, and physical function; reduced sexual function; depressed mood; and decreased cognitive function. Similar changes occur in young men with androgen deficiency and are improved with T replacement therapy. However, the physiological and clinical significance of the aging-associated decline in serum T levels in men is unclear, particularly because T levels may remain within the normal range for young men. From a practical clinical standpoint, it is most appropriate to define “andropause” as an age-related decline in serum T levels in older men to below the normal range in young men that is associated with a clinical syndrome (i.e., symptoms and signs) consistent with androgen deficiency. The decline in T levels is a consequence both of aging per se and age-associated comorbid illnesses and medications that are used to treat them
The Problem with Threads (2006)

For concurrent programming to become mainstream, we must discard threads as a programming model. Nondeterminism should be judiciously and carefully introduced where needed, and it should be explicit in programs. In general-purpose software engineering practice, we have reached a point where one approach to concurrent programming dominates all others namely, threads, sequential processes that share memory. They represent a key concurrency model supported by modern computers, programming languages, and operating systems. In scientific computing, where performance requirements have long demanded concurrent programming, data-parallel language extensions and message-passing libraries such as PVM, MPI, and OpenMP dominate over threads for concurrent programming. Computer architectures intended for scientific computing often differ significantly from so-called general-purpose architectures.
Molecular typing of Borrelia burgdorferi sensu lato by PCR-restriction fragment length polymorphism analysis (1995)

The etiologic agent of Lyme borreliosis, Borrelia burgdorferi sensu lato, has been isolated from many biologic sources in North America and Eurasia, and isolates have been divided into three distinct genospecies (B. burgdorferi sensu stricto, Borrelia garinii, and Borrelia afzelii). In order to explore the possible association of genospecies with disease manifestation, 60 isolates of B. burgdorferi sensu lato were subjected to 5S rDNA-linked restriction fragment length polymorphism (RFLP) analysis. The results confirmed earlier studies which indicated that virtually all North American isolates are B. burgdorferi sensu stricto, whereas Eurasian strains fall into all three genospecies. Thirty-five isolates were further characterized by PCR amplification of a region of the 16S-23S rDNA spacer and HinfI digestion of the products. This method resulted in the subdivision of B. burgdorferi sensu stricto into two distinct PCR-RFLP types. In contrast, B. garinii isolates all displayed an identical pattern. Additionally, a number of previously unclassified North American isolates (25015, DN127, 19857, 24330) showed distinctively different PCR-RFLP patterns. The application of this method for the typing of uncultured B. burgdorferi directly in biologic samples was demonstrated by analysis of several field-collected Ixodes scapularis tick specimens. The described PCR-RFLP technique should allow for the direct and rapid molecular typing of B. burgdorferi-containing samples and facilitate studies of the relationship between spirochete genotype and clinical disease.
Effects of α2-Plasmin Inhibitor on Fibrin Clot Lysis. Its Comparison with α2-Macroglobulin (1978)

Summary The major plasmin inhibitors namely α2-plasmin inhibitor and α2-macroglobulin were compared for their effects on lysis of fibrin clot. Plasmin fibrinolytic activity was immediately inhibited by α2-plasmin inhibitor, whereas α2-macroglobulin inhibited plasmin progressively. Urokinase(plasminogen activator)-induced clot lysis was inhibited efficiently by α2-plasmin inhibitor present in the clot. Inhibition of urokinase-induced clot lysis by α2-macroglobulin was weak and the molar concentration necessary for α2-macroglobulin to achieve the same degree of inhibition as that achieved with α2-plasmin inhibitor was about 10 times higher than that of α2-plasmin inhibitor. Binding of Lys-plasminogen to fibrin was inhibited by α2-plasmin inhibitor but not by α2-macroglobulin. Molar concentrations of α2-plasmin inhibitor which were effective in inhibiting the binding were 30 times less than that of 6-aminohexanoic acid. α2-Plasmin inhibitor was found to interact with Lys-plasminogen to form a weakly-bound complex which is dissociable in the presence of 6-aminohexanoic acid, suggesting that inhibition of binding of Lys-plasminogen to fibrin by α2-plasmin inhibitor may be due to interaction of α2-plasmin inhibitor with a specific site of the plasminogen molecule and that the site may be 6-aminohexanoic acid-binding site. It is suggested that α2-plasmin inhibitor is more reactive and efficient inhibitor of fibrinolysis than α2-macroglobulin.
Cancer statistics in China, 2015 (2016)

With increasing incidence and mortality, cancer is the leading cause of death in China and is a major public health problem. Because of China's massive population (1.37 billion), previous national incidence and mortality estimates have been limited to small samples of the population using data from the 1990s or based on a specific year. With high-quality data from an additional number of population-based registries now available through the National Central Cancer Registry of China, the authors analyzed data from 72 local, population-based cancer registries (2009-2011), representing 6.5% of the population, to estimate the number of new cases and cancer deaths for 2015. Data from 22 registries were used for trend analyses (2000-2011). The results indicated that an estimated 4292,000 new cancer cases and 2814,000 cancer deaths would occur in China in 2015, with lung cancer being the most common incident cancer and the leading cause of cancer death. Stomach, esophageal, and liver cancers were also commonly diagnosed and were identified as leading causes of cancer death. Residents of rural areas had significantly higher age-standardized (Segi population) incidence and mortality rates for all cancers combined than urban residents (213.6 per 100,000 vs 191.5 per 100,000 for incidence; 149.0 per 100,000 vs 109.5 per 100,000 for mortality, respectively). For all cancers combined, the incidence rates were stable during 2000 through 2011 for males (+0.2% per year; P = .1), whereas they increased significantly (+2.2% per year; P < .05) among females. In contrast, the mortality rates since 2006 have decreased significantly for both males (-1.4% per year; P < .05) and females (-1.1% per year; P < .05). Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
A Proposal on an Optimized Device Structure With Experimental Studies on Recent Devices for the DRAM Cell Transistor (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We have experimentally analyzed the leakage mechanism and device degradations caused by the Fowler–Nordheim (F–N) and hot carrier stresses for the recently developed dynamic random-access memory cell transistors with deeply recessed channels. We have identified the important differences in the leakage mechanism between saddle fin (S-Fin) and recess channel array transistor (RCAT). These devices have their own respective structural benefits with regard to leakage current. Therefore, we suggest guidelines with respect to the optimal device structures such that they have the advantages of both S-Fin and RCAT structures. With these guidelines, we propose a new recess-FinFET structure that can be realized by feasible manufacturing process steps. The structure has the side-gate form only in the bottom channel region. This enhances the characteristics of the threshold voltage (<formula formulatype="inline"><tex>$V_{\rm TH}$</tex></formula>), <emphasis emphasistype="smcaps"> ON</emphasis>/<emphasis emphasistype="smcaps">OFF</emphasis> currents, and the retention time distributions compared with the S-Fin structure introduced recently. </para>
Case management may reduce length of hospital stay in patients with recurrent admissions for chronic obstructive pulmonary disease (2001)

In a group of patients with severe COPD and recurrent admissions, case management reduced the number of days in hospital while improving the quality of life. These findings need to be confirmed in a randomized, controlled trial.
Recombinant Factor IX (1997)

Despite the introduction of recombinant preparations of factor VIII and recombinant factor VII and VIIa, patients with other forms of hemophilia, especially hemophilia B, have remained at increased risk for blood borne viruses because of a lack of clinically utilizable preparations of recombinant factor IX. This report describes the state of current tests with a recently licensed preparation of recombinant factor IX, BeneFix, from Genetics Institute. Structurally, functionally, and therapeutically, recombinant factor IX is comparable to monoclonal plasma-derived factor IX. The only observed difference between recombinant and plasma factor IX is the recovery in pharmacokinetic studies where recombinant factor IX recovery was approximately 72% that of a plasma factor IX product. This difference is attributed to be due to minor differences in the post-translational modification of recombinant factor IX compared to plasma. These studies demonstrate that recombinant factor IX is effective in the treatment of hemophilia B and has the safety profile expected from a product prepared by recombinant technology.
A Microfabricated Fluidic Device for Performing Two-Dimensional Liquid-Phase Separations (2000)

A microfabricated fluidic device that combines micellar electrokinetic chromatography and high-speed open-channel electrophoresis on a single structure for the rapid automated two-dimensional analysis of peptides has been devised and demonstrated. The microchip operates by rapidly sampling and analyzing effluent in the second dimension from the first dimension. Second-dimension analyses are performed and completed every few seconds, with total analysis times of less than 10 min for tryptic peptides. The peak capacity of the two-dimensional separations has been estimated to be in the 500-1000 range. The orthogonality of the separation techniques, an important factor for maximizing peak capacity or resolution elements, was verified by examining each technique independently for peptide separations. The two-dimensional separation strategy was found to greatly increase the resolving power over that obtained for either dimension alone.
Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation (2004)

Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified. The purpose of this study was to determine if pulmonary exposure to a PM surrogate, such as residual oil fly ash (ROFA), affects endothelium-dependent dilation in the systemic microcirculation. Rats were intratracheally instilled with ROFA at 0.1, 0.25, 1 or 2 mg/rat 24 hr before experimental measurements. Rats intratracheally instilled with saline or titanium dioxide (0.25 mg/rat) served as vehicle or particle control groups, respectively. In vivo microscopy of the spinotrapezius muscle was used to study systemic arteriolar dilator responses to the Ca2+ ionophore A23187, administered by ejection via pressurized micropipette into the arteriolar lumen. We used analysis of bronchoalveolar lavage (BAL) samples to monitor identified pulmonary inflammation and damage. To determine if ROFA exposure affected arteriolar nitric oxide sensitivity, sodium nitroprusside was iontophoretically applied to arterioles of rats exposed to ROFA. In saline-treated rats, A23187 dilated arterioles up to 72 +/- 7% of maximum. In ROFA- and TiO2-exposed rats, A23187-induced dilation was significantly attenuated. BAL fluid analysis revealed measurable pulmonary inflammation and damage after exposure to 1 and 2 mg ROFA (but not TiO2 or < 1 mg ROFA), as evidenced by significantly higher polymorphonuclear leukocyte cell counts, enhanced BAL albumin levels, and increased lactate dehydrogenase activity in BAL fluid. The sensitivity of arteriolar smooth muscle to NO was similar in saline-treated and ROFA-exposed rats, suggesting that pulmonary exposure to ROFA affected endothelial rather than smooth muscle function. A significant increase in venular leukocyte adhesion and rolling was observed in ROFA-exposed rats, suggesting local inflammation at the systemic microvascular level. These results indicate that pulmonary PM exposure impairs systemic endothelium-dependent arteriolar dilation. Moreover, because rats exposed to < 1 mg ROFA or TiO2 did not exhibit BAL signs of pulmonary damage or inflammation, it appears that PM exposure can impair systemic microvascular function independently of detectable pulmonary inflammation.
[The significance of serum leucine aminopeptidase (P-LAP) determination in the gynecological malignancies]. (1985)

We determined Placental-Leucine Aminopeptidase (P-LAP) activity, one of the oncodevelopmental antigens, in sera and in tissues of patients with gynecological cancers. The incidence of P-LAP activity and clinical usefulness of the determination of serum P-LAP activity were studied. The mean level in healthy non-pregnant sera used as controls was 6.0 +/- 2.4mg/dl/h. The mean level of P-LAP activity in patients with benign tumors such as myoma uteri and benign ovarian tumor did not increase in comparison with the controls. The mean level of P-LAP activity in patients with malignant tumor increased with advancing stages, and especially in advanced cervical and ovarian cancer, serum P-LAP levels were significantly higher than in the controls. Serum P-LAP activity correlated with the serum ferritin concentration (r=0.613), but not with the serum alpha-fetoprotein and serum carcinoembryonic antigen concentration. Serial measurements of serum P-LAP activities in patients with gynecological cancer showed that serum P-LAP activity might reflect the progress of cervical and ovarian cancer. Tissue P-LAP activities in 29 ovarian cancers were compared with those in normal tissues. Tissue P-LAP activities in 26 cases out of 29 increased to twice as high as the mean activities in 10 normal ovaries. Our present results suggest the possibility of using P-LAP activity as one of tumor markers for gynecological malignant tumors.
Epitope mapping using combinatorial phage-display libraries: a graph-based algorithm (2006)

A phage-display library of random peptides is a combinatorial experimental technique that can be harnessed for studying antibody-antigen interactions. In this technique, a phage peptide library is scanned against an antibody molecule to obtain a set of peptides that are bound by the antibody with high affinity. This set of peptides is regarded as mimicking the genuine epitope of the antibody's interacting antigen and can be used to define it. Here we present PepSurf, an algorithm for mapping a set of affinity-selected peptides onto the solved structure of the antigen. The problem of epitope mapping is converted into the task of aligning a set of query peptides to a graph representing the surface of the antigen. The best match of each peptide is found by aligning it against virtually all possible paths in the graph. Following a clustering step, which combines the most significant matches, a predicted epitope is inferred. We show that PepSurf accurately predicts the epitope in four cases for which the epitope is known from a solved antibody-antigen co-crystal complex. We further examine the capabilities of PepSurf for predicting other types of protein-protein interfaces. The performance of PepSurf is compared to other available epitope mapping programs.
Scaling carbon nanotube complementary transistors to 5-nm gate lengths (2017)

High-performance top-gated carbon nanotube field-effect transistors (CNT FETs) with a gate length of 5 nanometers can be fabricated that perform better than silicon complementary metal-oxide semiconductor (CMOS) FETs at the same scale. A scaling trend study revealed that the scaled CNT-based devices, which use graphene contacts, can operate much faster and at much lower supply voltage (0.4 versus 0.7 volts) and with much smaller subthreshold slope (typically 73 millivolts per decade). The 5-nanometer CNT FETs approached the quantum limit of FETs by using only one electron per switching operation. In addition, the contact length of the CNT CMOS devices was also scaled down to 25 nanometers, and a CMOS inverter with a total pitch size of 240 nanometers was also demonstrated.
Internet Security Professional Reference (1996)

From the Publisher:
This comprehensive reference details how Internet and network security is implemented and explains ways you can keep it from being violated. Inadequacies in current security products and setups are pointed out and strategies to overcome them are detailed step by step. Security issues such as daemons, auditing, IP spoofing and sniffing, firewalls, encryption, Java security, CGI security, and viruses are covered in thorough detail. Hands-on instruction of security tools such as SATAN, Kerberos, and PGP is also included. Whether you're planning to implement an Internet security system or optimize an existing one, Internet Security Professional Reference has all the answers you need!
Protein Encapsulation via Polypeptide Complex Coacervation (2014)

Proteins have gained increasing success as therapeutic agents; however, challenges exist in effective and efficient delivery. In this work, we present a simple and versatile method for encapsulating proteins via complex coacervation with oppositely charged polypeptides, poly(l-lysine) (PLys) and poly(d/l-glutamic acid) (PGlu). A model protein system, bovine serum albumin (BSA), was incorporated efficiently into coacervate droplets via electrostatic interaction up to a maximum loading of one BSA per PLys/PGlu pair and could be released under conditions of decreasing pH. Additionally, encapsulation within complex coacervates did not alter the secondary structure of the protein. Lastly the complex coacervate system was shown to be biocompatible and interact well with cells in vitro. A simple, modular system for encapsulation such as the one presented here may be useful in a range of drug delivery applications.
Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model (2015)

This work was supported by grant MOP-123259 to the late Dr Ali Akoum from the Canadian Institutes for Health Research. The authors have no conflict of interest.
Fos-Related Antigen 1 Modulates Malignant Features of Glioma Cells (2005)

Malignant gliomas, and high-grade gliomas (HGG) in particular, are nonmetastasizing but locally infiltrating, hypervascularized brain tumors of poor prognosis. We found previously that a c-fos-inducible vascular endothelial growth factor D is ubiquitously up-regulated in HGG grade IV, glioblastoma multiforme, and that glioblastoma multiforme overexpress Fos-related antigen 1 (Fra-1) rather than the c-Fos. We have thus become interested in the role Fra-1 may play in malignant glioma progression/maintenance, because Fra-1 has the capacity to modulate transcription of a variety of target genes. In this work, we have analyzed the biological effects of ectopic Fra-1 expression or Fra-1 knockdown in malignant glioma cells. Ectopic Fra-1 induced prominent phenotypic changes in all three malignant glioma cell lines examined: H4, U-87 MG, and A-172 MG. These changes were reflected in cells becoming more elongated with larger number of cellular processes. Furthermore, Fra-1 transgene caused H4 cells, which do not form tumor xenografts, to regain tumorigenic capacity. The genotype of these cells changed too, because 50 of 1,056 genes examined became either up-regulated or down-regulated. Conversely, Fra-1 knockdown altered prominently the morphology, anchorage-independent growth, tumorigenic potential, and Fra-1 effector expression, such as vascular endothelial growth factor D, in HGG cells. For example, cells transfected with antisense fra-1 showed shorter cellular processes than the control cells that did not grow in agar, and their tumorigenic potential was significantly diminished. Thus, Fra-1 may likely play an important role in the maintenance/progression of malignant gliomas and potentially represents a new target for therapeutic interventions.
21세기 문명의 전환: 아시아 공동체를 향하여 (2003)

데카르트 이래의 기계론적 세계관에 바탕을 둔 서구의 정치적 패러다임은 공산주의에서 문명충돌에 이르기까지 위기에 직면한 서구문명과 국제정치를 더욱 대결과 투쟁으로 치닫게 할 수밖에 없다. 따라서 서구인들의 관심은 조화와 상생과 대동의 동양적 세계관으로 전이해 가고 있다. 이에 자극을 받은 아시아인들은 경제발전에 힘입어 아시아적 가치와 정체성의 확립에 주목하게 됐고 이는 아시아공동체 건설에 대한 열망으로 이어지고 있다. 아시아공동체의 안정적 구축을 위해서는 전략적으로 동아시아공동체 건설이 전제되어야 한다. 그래야만 그 속에서 한민족은 신인류문명을 탄생시킬 수 있는 창조적 역할을 수행할 수 있을 것이다.
On latching probability of particle induced transients in combinational networks (2002)

The question to what extent particle induced transients in combinational parts of a circuit propagate into memory elements is addressed in this paper An experimental method is presented in which the proportion of bit flips originating from heavy-ion hits in combinational logic is determined. It is proposed that a voltage pulse may only propagate through a limited number of transistor stages and still be latched. The proportion of all transients in combinational logic that were latched into registers was experimentally, estimated to be between 0.7/spl middot/10/sup -3/ and 2/spl middot/10/sup -3/ for a custom designed CMOS circuit. Very few multiple bit flips were observed during the experiments which indicates that the single bit flip model used in many high-level simulations is reasonable accurate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comparative studies of conformation and internal mobility in native and circular basic pancreatic trypsin inhibitor by 1H nuclear magnetic resonance in solution (1985)

A circular derivative of bovine pancreatic trypsin inhibitor (c-BPTI) with the C- and N-termini covalently linked with a peptide bond, has been studied in solution by spectroscopic techniques, principally two-dimensional 1H NMR. Near complete sequence specific assignment of the 1H NMR spectrum of c-BPTI has been obtained in a highly efficient manner, using recently developed experimental techniques. The assignments serve as the necessary background for detailed examination of the effects of the chemical modification on global and local features of the protein conformation and on the internal mobility. Analysis of chemical shifts, spin-spin coupling constants, amide proton exchange and proton-proton Overhauser enhancements indicates that perturbations of the native BPTI conformation in c-BPTI involve exclusively residues adjacent to the modification site. The strict localization and small magnitude of the conformation changes relative to native BPTI emphasize the important role of the salt bridge between the chain ends in determining the solution conformation and dynamics in the chain terminal regions of the native protein.