gebhart/patrepeval huggingface dataset:
Process variation aware cache leakage management (2006)

In a few technology generations, limitations of fabrication processes will make accurate design time power estimates a daunting challenge. Static leakage current which comprises a significant fraction of total power due to large on-chip caches, is exponentially dependent on widely varying physical parameters such as gate length, gate oxide thickness, and dopant ion concentration. In large structures like on-chip caches, this may mean that one portion of a cache may consume an order of magnitude larger static power than equivalently sized regions.Under this climate, egalitarian management of physical resources is clearly untenable. In this paper, we analyze the effects of within-die and die-to-die leakage variation for on-chip caches. We then propose way prioritization, a manufacturing variation aware scheme that minimizes cache leakage energy. Our results show that significant average power reductions are possible without undue hardware complexity or performance compromise.
ChemInform Abstract: Photoinduced Fluorescence Changes on E—Z Isomerization in Azobenzene Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein (2002)

We have cloned a gene encoding a fluorescent protein from a stony coral, Trachyphyllia geoffroyi, which emits green, yellow, and red light. The protein, named Kaede, includes a tripeptide, His-Tyr-Gly, that acts as a green chromophore that can be converted to red. The red fluorescence is comparable in intensity to the green and is stable under usual aerobic conditions. We found that the green-red conversion is highly sensitive to irradiation with UV or violet light (350-400 nm), which excites the protonated form of the chromophore. The excitation lights used to elicit red and green fluorescence do not induce photoconversion. Under a conventional epifluorescence microscope, Kaede protein expressed in HeLa cells turned red in a graded fashion in response to UV illumination; maximal illumination resulted in a 2,000-fold increase in the ratio of red-to-green signal. These color-changing properties provide a simple and powerful technique for regional optical marking. A focused UV pulse creates an instantaneous plane source of red Kaede within the cytosol. The red spot spreads rapidly throughout the cytosol, indicating its free diffusibility in the compartment. The extensive diffusion allows us to delineate a single neuron in a dense culture, where processes originating from many different somata are present. Illumination of a focused UV pulse onto the soma of a Kaede-expressing neuron resulted in filling of all processes with red fluorescence, allowing visualization of contact sites between the red and green neurons of interest.
Optical Coherence Tomography Machine Learning Classifiers for Glaucoma Detection: A Preliminary Study (2005)

Automated machine classifiers of OCT data might be useful for enhancing the utility of this technology for detecting glaucomatous abnormality.
Wrinkles energy based age estimation using discrete cosine transform (2015)

Human's faces are true representative of a human and information like gender, age and origin about a human. Age estimation on the bases of facial image is a complex phenomenon for the computer vision systems to predict human's age effectively. Facial image based Age estimation analysis has a lot of real world applications e.g. human computer interaction (HCI) and multimedia communication. In this paper a new method to predict human's age is presented. The proposed method is focusing on cheek's area and wrinkles analysis using discrete cosine transform (DCT). As the wrinkles on human face increase with increasing age, so it has been used as discriminating factor for age estimation. DCT is applied on the wrinkle detected. The energy in higher coefficients of DCT increases with the increasing wrinkle in other words with increasing age.
Cryogenic Microcracking of Carbon Fiber/Epoxy Composites: Influences of Fiber-Matrix Adhesion (2003)

The impact of fiber-matrix adhesion on the transverse microcracking of fiber reinforced polymeric materials thermally cycled at cryogenic temperatures was investigated using symmetric cross-ply carbon fiber/epoxy laminates containing fibers with different surface treatments. Past research explored the role of fiber-matrix adhesion in determining the room temperature properties of composite materials, but this work is original in that it examined how fiber-matrix adhesion affected the behavior of composite materials at cryogenic temperatures. Three fiber surfaces were used: Unsized but exposed to an oxidative surface treatment, epoxy sized, and surfactant sized. Modifications of the fiber surfaces changed the adhesion of the matrix to the fibers as determined by interlaminar shear strength and dynamic mechanical analysis. The extent of microcracking in the laminates exhibited a dependence on fiber-matrix adhesion, with high levels of adhesion corresponding to decreased microcracking.
Malignant Lymphoma of the Thyroid Gland (2000)

We report a retrospective clinicopathologic study of 108 primary thyroid gland lymphomas (PTLs), classified using the REAL and proposed WHO classification schemes. The patients included 79 women and 29 men, with an average age of 64.3 years. All patients presented with a thyroid mass. The PTLs were classified as marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) or MZBL (n = 30), diffuse large B-cell lymphoma (DLBCL) with MZBL (n = 36), DLBCL without MZBL (n = 41), and follicle center lymphoma (FCL; n = 1). Excluding the FCL, features of lymphomas of MALT-type were identified in all groups, despite a follicular architecture in 23% of cases. Lymphocytic thyroiditis (LT) was identified in 94%. Ninety-one percent of patients presented with stage IE or IIE disease, whereas 69% had perithyroidal soft tissue infiltration. All patients were treated with surgical excision followed by adjuvant therapy (76%): chemotherapy (15%), radiation (19%), or a combination of radiation and chemotherapy (42%). Disease-specific survival was 82% at last follow up (mean, 82.8 mos) and 79% at 5 years. Statistically, stages greater than IE, presence of DLBCL, rapid clinical growth, abundant apoptosis, presence of vascular invasion, high mitotic rate, and infiltration of the perithyroidal soft tissue were significantly associated with death with disease. No patients with MZBL or stage IE disease died with disease. In summary, PTLs typically occur in middle- to older-aged individuals as a thyroid mass, with a predilection for females. Despite their histologic heterogeneity and frequent simulation of other lymphoma subtypes, virtually all PTLs are lymphomas of MALT-type arising in the setting of LT. Mixed DLBCL and MZBL are common. Overall, PTLs have a favorable outcome with appropriate therapy, but prognosis depends on both clinical stage and histology. MZBL and stage IE tumors have an excellent prognosis, whereas tumors with a large cell component or DLBCL or stage greater than IE have the greatest potential for a poor outcome.
Revised formulas for summarizing retinal vessel diameters (2003)

Background/Purpose. Recent findings suggest that an objective assessment of retinal vessel caliber from fundus photographs provide information about the association of microvascular characteristics with macrovascular disease. Current methods used to quantify retinal vessel caliber, introduced by Parr(1,2) and Hubbard,(3) are not independent of scale and are affected by the number of vessels. To improve upon these methods we introduce revised formulas for quantifying vessel caliber. Methods. Revised formulas were estimated using retinal vessel measurements from 44 young adults free of hypertension and diabetes. Comparisons between the two methods were done using digitized photographs from 4926 participants at the baseline examination of the Beaver Dam Eye Study (BDES), an ongoing population-based cohort study initiated in 1987. Individual arterioles and venules were measured using semi-automated computer software from which summary measures were calculated. Results. Correlation coefficients between the Parr-Hubbard and revised formulas were high (Pearson correlation coefficients ranging from 0.94 to 0.98). Both arteriolar and venular caliber significantly increased with an increasing number of vessels measured using the Parr-Hubbard formulas (p < 0.001), which in turn affected the relationship to mean arterial blood pressure. To the contrary, the revised formulas were not affected by the number of measured vessels (p > 0.50). Conclusions. We describe revised formulas for summarizing retinal vessel diameters measured from fundus photographs to be used in future studies and analyses. The revised formulas correlate highly with the previously used Parr-Hubbard formulas, but offer the advantages of being more robust against variability in the number of vessels observed, being independent of image scale, and being easier to implement.
Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines. (1988)

The gastrointestinal hormone gastrin has been shown to stimulate the growth of normal colonic mucosa. To examine for a possible role of gastrin in the proliferation of cultured colon tumor cells, we have studied the effects of two gastrin receptor antagonists, proglumide and benzotript, and of antibodies to gastrin. We find that proglumide (50% effective concentration, 2 to 5 mM) and benzotript (50% effective concentration, 0.4 to 0.8 mM) inhibit the monolayer growth of six human colon cancer cell lines. Addition of exogenous gastrin abrogated the growth-inhibitory effect of proglumide. The anchorage-independent growth of colon carcinoma cells was also inhibited by the two gastrin antagonists. Also, a dose-dependent increase in carcinoembryonic antigen secretion was observed upon treatment with proglumide and benzotript in three cell lines examined. Half-maximal inhibition of labeled gastrin binding was observed at concentrations of 0.4 mM benzotript and 8.6 mM proglumide. In addition, antigastrin antiserum added to HCT 116 cells adapted to growth in serum-free medium resulted in a concentration-dependent inhibition of cellular proliferation. These data suggest that gastrin may function as an autocrine growth factor in colon carcinoma.
Prevalence and types of dementia in the very old (1994)

We report on the prevalence of dementia in Canadians age 85 years and older. The purpose of this study was to determine whether the prevalence of dementia continued to increase in the very old, and to define the types of dementia and their relative proportions in this age group. We collected data as part of the Canadian Study of Health and Aging (1990 to 1992), which consisted of a sample of 1,835 subjects from a population of 283,510 Canadians who were 85 years of age and older residing in the community or in institutions. The prevalence of dementia in the 85 years and older group was 28.5%, more than twice that of the 75- to 84-years cohort. The prevalence of dementia of 23% in the 85- to 89-years sample (n = 1,332) increased to 40% in the 90 to 94 years group (n = 371) and, in the 95 years and older sample (n = 104), reached 58%. Overall, Alzheimer's disease (AD; probable or possible) accounted for 75% of all dementias; a vascular etiology alone accounted for 13% of dementias. The proportion of clinically diagnosed AD cases to vascular dementia cases increased significantly after age 65 and was higher in the 85+ group than in a younger cohort (65 to 84 years).
Association of Loci Underlying Field Resistance to Soybean Sudden Death Syndrome (SDS) and Cyst Nematode (SCN) Race 3 (1997)

Coinheritance of field resistance of soybean [ Glycine max (L.) Merr.] to sudden death syndrome (SDS) [caused by the fungus Fusarium solani (Mart.) Sacc. f. sp. phaseoli (Burk.) Snyd. &amp; Hans.] and soybean cyst nematode (SCN) race 3 (caused by Heterodera glycines Ichinohe) sometimes occurs in crosses among adapted cultivars. Our objective was to characterize the loci underlying this coinheritance. One hundred thirty DNA markers were compared with SDS disease response and SCN score among 100 recombinant inbred lines (RILs) derived from a cross between SDS and SCN resistant ‘Forrest’ and SDS and SCN susceptible ‘Essex’. SDS disease incidence (DI) was determined in replicated sites during 4 yr encompassing five locations. The SCN score was determined in the greenhouse from naturally infested field soil samples. Two separate genomic regions identified by random amplified polymorphic DNA (RAPD) markers OI03 450 and OW15 400 were associated with mean SCN score ( P = 0.0001) and jointly accounted for about 47% of variability in SCN score. OI03 450 identified a QTL for resistance to SCN ( R 2 = 14%) within a genomic region that was strongly associated with SDS DI ( R 2 = 20%), partly explaining the coinheritance of the two traits. This locus could be assigned to the region of linkage group G already known to encompass the major SCN resistance locus.
How can the Voluntary Sector get its act together? (1991)

The following article is an edited version o f the SRAB Annual Lecutre given at the National Westminster Hall, London, 22 November 1990. The author discusses the need to ensure further collaboration between the various voluntary associations involved with visually impaired people and describes some of the ways in which this might be achieved, within the framework of the group of which he is the Chairman.
Cationic Porphyrins as Telomerase Inhibitors:  the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNARichard T. Wheelhouse, Daekyu Sun, Haiyong Han, Frank Xiaoguang Han, and Laurence H. HurleyView Author Information Drug Dynamics Institute, College of Pharmacy The University of Texas at Austin, Austin, Texas 78712 Institute for Drug Development, 14960 Omicron Drive San Antonio, Texas 78245 Cite this: J. Am. Chem. Soc. 1998, 120, 13, 3261–3262Publication Date (Web):March 20, 1998Publication History Received4 November 1997Published online20 March 1998Published inissue 1 April 1998https://pubs.acs.org/doi/10.1021/ja973792ehttps://doi.org/10.1021/ja973792erapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views2750Altmetric-Citations370LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Crystal cleavage,Genetics,Peptides and proteins,Pyrroles Get e-Alerts
Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain (1998)

A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H2O2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H2O2 generation. This H2O2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.
Monitoring antigenemia is useful in guiding treatment of severe cytomegalovirus disease after organ transplantation (1992)

Abstract. We investigated the value of monitoring CMV antigenemia during and after antiviral therapy for CMV disease. During the study period, 10 out of 214 renal transplant recipients were treated for CMV disease, receiving a total of 14 courses of treatment. Antigenemia decreased within 7 days after onset of treatment in eight of nine courses associated with a rapid clinical recovery. In three courses with a slow or absent response, antigenemia levels initially increased. Monitoring antigenemia was helpful in differentiating persisting CMV disease from other opportunistic infections and rejection. Relapses of CMV disease were preceded by rises in antigenemia. Viral isolation became negative within 3 days after initiation of ganciclovir, irrespective of the clinical response. Antigenemia is a marker of the effect of ganciclovir on CMV replication in vivo, and its monitoring may be valuable in the management of patients with severe CMV disease.
Kidney–targeted drug delivery systems (2014)

Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.
Prenatal diagnosis on fetal cells obtained from maternal peripheral blood: Report of 66 cases (1999)

The potential use of fetal cells circulating in maternal blood for a non-invasive prenatal diagnosis has been widely described. Several authors have developed different methods for the enrichment of fetal cells from maternal peripheral blood. The aim of this study was to make a practical valuation of this new prenatal diagnosis technique, using those methods described as efficient and easy to carry out in a prenatal diagnosis unit. These methods consist of the double-density gradient and the positive selection by magnetic activated cell sorting (MACS) of the fetal erythroblasts, and the posterior study of the cells applying the FISH interphasic technique. Once the technique was ready, we obtained results from the study of 66 venous blood samples from women coming for prenatal diagnosis. Using a specific staining for fetal haemoglobin, fetal cells were identified in 63 cases. Fetal sex was well determined in 56 cases, 23 females and 33 males; in 7 cases the sex determination failed. All the aneuploidies found in a previous prenatal diagnosis were confirmed.
Masterless Soft Lithography:  Patterning UV/Ozone−Induced Adhesion on Poly(dimethylsiloxane) Surfaces (2005)

A novel microreactor-based photomask capable of effecting high resolution, large area patterning of UV/ozone (UVO) treatments of poly(dimethylsiloxane) (PDMS) surfaces is described. This tool forms the basis of two new soft lithographic patterning techniques that significantly extend the design rules of decal transfer lithography (DTL). The first technique, photodefined cohesive mechanical failure, fuses the design rules of photolithography with the contact-based adhesive transfer of PDMS in DTL. In a second powerful variation, the UVO masks described in this work enable a masterless soft lithographic patterning process. This latter method, UVO-patterned adhesive transfer, allows the direct transfer of PDMS-based polymer microstructures from a slab of polymer to silicon and other material surfaces. Both methods exploit the improved process qualities that result from the use of a deuterium discharge lamp to affect the UVO treatment to pattern complex, large area PDMS patterns with limiting feature sizes extending well below 1 microm (> or = 0.3 microm). The use of these structures as resists is demonstrated for the patterning of metal thin films. A time-of-flight secondary ion mass spectroscopy study of the process provides new insights into the mechanisms that contribute to the chemistry responsible for the interfacial adhesion of DTL transfers.
An intravenous injection simulator using augmented reality for veterinary education and its evaluation (2012)

This paper proposes a simulator for veterinary education based on augmented reality. We selected an intravenous injection procedure for the simulation because the injection procedure is the most frequently used procedure during veterinary training and the most difficult stage for beginning veterinary students. The proposed AR simulator provides with a tangible prop, of which shape looks like a leg of a real dog. It also has an injection simulator, which receives user's input and sends force feedbacks to indicate results of the injection simulation. We developed a Workbench type AR system with an LED display and cameras for visual information processing. Finally, we evaluated its performance through experiments and user studies to check its acceptance level and usability of the proposed system. We compared the proposed system with a VR based system using a monitor. The results showed that the proposed system showed better performances over these systems.
Provably secure obfuscation of diverse watermarks for sequential circuits (2010)

This paper presents a provably secure method for embedding multiple watermarks in sequential designs. A number of different watermarks signed with the IP owner's secret key from a public key cryptography system are generated. The owner's watermarks are then dissembled into the states and transitions of the original sequential design. Hiding the multiple watermarks in the states and transitions is shown to be an instance of obfuscating a multi-point function with a generalized output. We draw on the theoretical cryptographic results of provable obfuscation of this function family to build a secure sequential multi-watermark system by construction. An iterative synthesis method for integrating the collection of watermarks to the original design is introduced. Analysis of watermark properties and the attack resiliency of the new multiple watermarking construction is presented. Experimental evaluations on benchmark circuits demonstrate practicality and low overhead of the new provably secure multiple watermarks construction method.
A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine (2018)

ClinicalTrials.gov as NCT02614287 , posted November 15, 2015. These data were previously presented as a poster at the International Headache Congress 2017: PO-01-184, Late-Breaking Abstracts of the 2017 International Headache Congress. (2017). Cephalalgia, 37(1_suppl), 319-374.