gebhart/patrepeval huggingface dataset:
Addition polymerization of norbornene catalyzed by palladium(2+) compounds. A polymerization reaction with rare chain transfer and chain termination (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition polymerization of norbornene catalyzed by palladium(2+) compounds. A polymerization reaction with rare chain transfer and chain terminationChristof Mehler and Wilhelm RisseCite this: Macromolecules 1992, 25, 16, 4226–4228Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ma00042a030https://doi.org/10.1021/ma00042a030research-articleACS PublicationsRequest reuse permissionsArticle Views629Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
L-ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure # † (2009)

L-Ornithine and phenylacetate act synergistically to successfully attenuate increases in arterial ammonia, which is accompanied by a significant decrease in extracellular brain ammonia and prevention of intracranial hypertension in pigs with ALF.
GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. (1995)

Using the yeast two-hybrid system we have identified a human protein, GAIP (G Alpha Interacting Protein), that specifically interacts with the heterotrimeric GTP-binding protein G alpha i3. Interaction was verified by specific binding of in vitro-translated G alpha i3 with a GAIP-glutathione S-transferase fusion protein. GAIP is a small protein (217 amino acids, 24 kDa) that contains two potential phosphorylation sites for protein kinase C and seven for casein kinase 2. GAIP shows high homology to two previously identified human proteins, GOS8 and 1R20, two Caenorhabditis elegans proteins, CO5B5.7 and C29H12.3, and the FLBA gene product in Aspergillus nidulans--all of unknown function. Significant homology was also found to the SST2 gene product in Saccharomyces cerevisiae that is known to interact with a yeast G alpha subunit (Gpa1). A highly conserved core domain of 125 amino acids characterizes this family of proteins. Analysis of deletion mutants demonstrated that the core domain is the site of GAIP's interaction with G alpha i3. GAIP is likely to be an early inducible phosphoprotein, as its cDNA contains the TTTTGT sequence characteristic of early response genes in its 3'-untranslated region. By Northern analysis GAIP's 1.6-kb mRNA is most abundant in lung, heart, placenta, and liver and is very low in brain, skeletal muscle, pancreas, and kidney. GAIP appears to interact exclusively with G alpha i3, as it did not interact with G alpha i2 and G alpha q. The fact that GAIP and Sst2 interact with G alpha subunits and share a common domain suggests that other members of the GAIP family also interact with G alpha subunits through the 125-amino-acid core domain.
Intraphagocytic Killing of Salmonella typhimurium by Liposome-Encapsulated Cephalothin (1983)

Multilamellar liposomes (lipid bilayer vesicles) composed of phosphatidylcholine, cholesterol, and phosphatidylserine (molar ratio, 6:3:1) were produced and then made to entrap an aqueous solution of cephalothin. Resident murine peritoneal macrophages were shown to be capable of interiorizing the liposome-antibiotic complex; this event resulted in a relatively high intracellular concentration of cephalothin. In macrophages infected in vitro with Salmonella typhimurium, intracellular killing of the bacteria was maximal at 60 min of incubation; at this time, 60% of the interiorized organisms had been killed. Treatment of infected macrophages with liposome-encapsulated cephalothin enhanced the intraphagocytic killing of S typhimurium over that by macrophages treated with free cephalothin. These results demonstrate the superiority of liposome-encapsulated antibiotics to free antibiotics in effecting the elimination of a facultative intracellular bacterium from its intracellular site. This type of complex may find application in the treatment of diseases caused by this group of microorganisms.
Scaling Energy Per Operation via an Asynchronous Pipeline (2012)

Statistical analysis of computations per unit energy in processors over the last 30 years is given that illustrates a sharp reduction in the rate of energy efficiency improvements over the last several years resulting in the formation of an asymptotic “wall” with our dataset; we use the measure of giga multiply accumulates per Joule. We have developed an energy model which takes into account the realities of scaling, specifically for asynchronous systems. Studies of an energy efficient asynchronous pipeline show fabricated results of 17 Giga Operations per Joule in 0.6 μm at subthreshold when fully pipelined, and simulations at a more modern 65 nm process show a further order of magnitude improvement on that.
Studies in Vernalisation of Cereals (1938)

Journal Article Studies in Vernalisation of Cereals: II. The Vernalisation of Excised Mature Embryos, and of Developing Ears Get access F. G. GREGORY, F. G. GREGORY From the Research Institute of Plant Physiology, Imperial College of Science and TechnologyLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar O. N. PURVIS O. N. PURVIS From the Research Institute of Plant Physiology, Imperial College of Science and TechnologyLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar Annals of Botany, Volume 2, Issue 1, January 1938, Pages 237–251, https://doi.org/10.1093/oxfordjournals.aob.a083997 Published: 01 January 1938
Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells (2008)

Osteopontin (Opn) contributes to diverse biological processes that include immune responses, vascularization, and bone formation. Until recently, studies describing the activities of Opn have focused on the cytokine-like properties of the secreted protein. Here, we show that alternative translation of a single Opn mRNA species generates a secreted and intracellular isoform. Utilization of a 5' canonical translation start site generates a protein that includes an N-terminal signal sequence allowing targeting to secretory vesicles and cytokine secretion, whereas usage of a downstream start site generates a shortened protein that lacks the N-terminal signal sequence and localizes mainly to cytoplasm. The coordinated action of these Opn gene products regulates the functional phenotype of subsets of dendritic cells.
Carbon Nanotube Arrays Prepared by MWCVD (2001)

Highly aligned carbon nanotubes (NTs) have been directly grown on metallic surfaces and in the channels of anodic aluminum oxide (AAO) templates at a low temperature by bias-enhanced microwave plasma chemical vapor deposition. Microwave plasma generated nanoparticles of various sizes (10−100 nm) on metallic surfaces, which acted as the catalyst for the formation of free-standing NTs. NTs with diameters of 40−50 nm had a high growth rate in the vertical direction, resulting in the formation of carbon tube arrays. The formation of NTs in the channels of AAO at the same experiment condition was a layer-by-layer deposition process of graphite.
Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration (1989)

In situ hybridization was used to quantitate the cells that produce erythropoietin (EP) in the renal cortices of mice with varying severities of acute anemia and of mice recovering from severe, acute anemia. The number of EP-producing cells in the renal cortex increased in an exponential manner as hematocrit was decreased. Individual EP-producing cells had very similar densities of silver grains in autoradiograms regardless of whether they were from normal mice or from slightly, moderately or severely anemic animals. With increasingly severe anemia, total renal EP mRNA levels and serum EP concentrations showed increases that correlated with the number of renal EP-producing cells. These results indicate that as mice become more anemic, additional cells are recruited to produce EP rather than the cells already producing EP being stimulated to increase their individual production. In mildly and moderately anemic animals, small clusters of EP-producing cells were found in the inner cortex with large areas of cortex containing no EP-producing cells. In severely anemic mice, EP-producing cells were found throughout the inner cortex with only a very few found scattered in the outer cortex and outer medulla. The data indicate that only a subset of total renal interstitial cells produce EP. During recovery from severe, acute anemia, the numbers of EP-producing cells decreased exponentially as hematocrits rose and correlated with decreases in total renal EP mRNA and serum EP concentrations. These results suggest that following an acute blood loss and during the recovery from a blood loss, the capacity to deliver oxygen, as represented by hematocrit, is the major regulator of EP production.
Diabetes and Cardiovascular Disease (2002)

This review focuses on several topics related to the epidemiology of diabetes and cardiovascular disease (CVD). These include the CVD risk factors common in the metabolic syndrome, behavioral risk factors and diabetes, gender differences in the association between diabetes and CVD risk, and how the clinical definition of diabetes influences the association of diabetes and CVD. Nontraditional risk factors potentially linking diabetes and CVD are also discussed, including chronic inflammation, advanced glycation endpoints, autonomic neuropathy, sleep-disordered breathing, and genetic susceptibility to diabetes-associated CVD risk.
Real-time Heading Determination Using an Integrated GPS-Dead Reckoning System (1992)

Detemmdon of vehicle heading in ml-time using two
GPSreceiversmountedonthevehicleroofisinve&@ted
using Magnavox GPS l3@neP. The main error sources
liiingthea&ievableauxacy~carrierphasenoiseand
multipath. A series of controlled low kinematic tests were
ptxformedtoassessthemagnitu&oftbeseerrasandresults
are given. A third compamt of maintainmg accumte
heading is the de&m&&o of & phase ambiguities
‘oa~fly’.IaorQertoassistintheestimati~ofinteger
ambiguities, the GF’S receivers 8ce integrated to several
dead-&o&g senscns including a compass, rate gyros,
odometer and altimeter. Using the wximate heading
from the dead-doning system, the mteger tzanier phase
ambiguities can ba edmated virtually instantaueously in
real-time. Tests demonstr&ng the achievable accumcy of
the intern system we desaiibed and results are dis-
cussed.
Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells (1984)

Glutamine is synthesized in skeletal muscle, released to the circulation, and transported to other tissues, where it may provide important substrate for gluconeogenesis, ammoniagenesis, and energy-yielding pathways. With the ultimate goal of delineating the factors that control glutamine production and release by skeletal muscle, we have studied the regulation of two key enzymes, glutamine synthetase and glutaminase, in the L6 line of rat skeletal muscle cells grown in monolayer culture. The cultured myotubes were found to have glutamine synthetase and phosphate-dependent glutaminase activities. Glutamine synthetase activity was increased following incubation (1) in glutamine-free medium (threefold); (2) in medium containing high glutamic acid concentrations (fourfold); and (3) in medium supplemented with dexamethasone (threefold). In each case the increase in glutamine synthetase activity required several hours to reach a maximum and was prevented by cycloheximide, suggesting that the change occurred through increased enzyme biosynthesis. No substances tested were found to affect glutaminase activity. We conclude that glutamine synthetase in cultured skeletal muscle is responsive to substrate, product, and hormonal regulation.
Sucrose mimics the light induction of Arabidopsis nitrate reductase gene transcription. (1992)

Nitrate reductase, the first enzyme in nitrate assimilation, is located at the crossroad of two energy-consuming pathways: nitrate assimilation and carbon fixation. Light, which regulates the expression of many higher-plant carbon fixation genes, also regulates nitrate reductase gene expression. Located in the cytosol, nitrate reductase obtains its reductant not from photosynthesis but from carbohydrate catabolism. This relationship prompted us to investigate the indirect role that light might play, via photosynthesis, in the regulation of nitrate reductase gene expression. We show that sucrose can replace light in eliciting an increase of nitrate reductase mRNA accumulation in dark-adapted green Arabidopsis plants. We show further that sucrose alone is sufficient for the full expression of nitrate reductase genes in etiolated Arabidopsis plants. Finally, using a reporter gene, we show that a 2.7-kilobase region of 5' flanking sequence of the nitrate reductase gene is sufficient to confer the light or the sucrose response.
In vivo analysis of the Saccharomyces cerevisiae HO nuclease recognition site by site-directed mutagenesis. (1990)

HO nuclease introduces a specific double-strand break in the mating-type locus (MAT) of Saccharomyces cerevisiae, initiating mating-type interconversion. To define the sequence recognized by HO nuclease, random mutations were produced in a 30-base-pair region homologous to either MAT alpha or MATa by a chemical synthesis procedure. The mutant sites were introduced into S. cerevisiae on a shuttle vector and tested for the ability to stimulate recombination in an assay that mimics mating-type interconversion. The results suggest that a core of 8 noncontiguous bases near the Y-Z junction of MAT is essential for HO nuclease to bind and cleave its recognition site. Other contacts must be required because substrates that contain several mutations outside an intact core reduce or eliminate cleavage in vivo. The results show that HO site recognition is a complex phenomenon, similar to promoter-polymerase interactions.
Integration of Organic FETs With Organic Photodiodes for a Large Area, Flexible, and Lightweight Sheet Image Scanners (2005)

A large-area, flexible, and lightweight sheet image scanner has been successfully manufactured on a plastic film by integrating high-quality organic transistors and organic photodetectors. The effective sensing area of the integrated device is 5/spl times/5 cm/sup 2/; the resolution, 36 dots per inch (dpi); and the total number of sensor cells, 5184. The pentacene transistors with top contact geometry have a channel length of 18 /spl mu/m and mobility of 0.7 cm/sup 2//Vs. Organic photodetectors composed of copper phthalocyanine and 3,4,9,10-perylene-tetracarboxylic-diimide distinguish between black and white parts on paper based on the difference in their reflectivity. Since this new area-type image-capturing device does not require any optics or mechanical scanning devices, the present sheet image scanners are mechanically flexible, lightweight, shock resistant, and potentially inexpensive to manufacture; therefore, they are suitable for human-friendly mobile electronics.
A Versatile Method for Suzuki Cross‐Coupling Reactions of Nitrogen Heterocycles (2006)

A wide-ranging study of Suzuki reactions which use nitrogen-containing heterocycles is described (see scheme; dba=dibenzylideneacetone, Cy=cyclohexyl). This method is highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a variety of unprotected functionalities (e.g., NH2- and OH-substituted substrates), and efficient even with unactivated aryl chlorides. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503479_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Analyses of Single B Cells by Polymerase Chain Reaction Reveal Rearranged VH with Germline Sequences in Spleens of Immunized Adult Rabbits: Implications for B Cell Repertoire Maintenance and Renewal (1998)

We used PCR to amplify rearranged VHDJH genes in single cells collected by micromanipulation from splenic germinal centers of immunized adult rabbits. In the course of the study, the objective of which was to analyze diversification of rearranged VHDJH sequences, we were surprised to find cells 7 and 10 days after immunization with rearranged VH1a2 as well as a-negative (y33 and x32) sequences that were identical or close to germline (10 or fewer changes). About 58% (82/140) of the sequences had unique CDR3 regions and were unrelated. In seven different germinal centers, we found one to four different clones with two to seven members. Clonally related cells underwent diversification by hypermutation and gene conversion. We found that contrary to published reports, adult rabbits indeed have newly diversifying B cell receptors in splenic germinal centers. The attractive idea that the rabbit, like the chicken, develops its B cell repertoire early in life and depends upon self-renewing cells in the periphery to maintain its B lymphocyte pool throughout life, is challenged by the current finding. Although a major population of B lymphocytes may be generated early in life, diversified extensively, and maintained by self-renewal in the periphery, some sources of cells with sequences close to germline do exist in adult rabbits and appear in the developing germinal centers. Although considerable repertoire diversity is generated in young rabbits, mechanisms for continued generation of B cell receptor diversity are retained in adult life, where they may confer survival advantage.
Alpha-Klotho Enrichment in Induced Pluripotent Stem Cell Secretome Contributes to Antioxidative Protection in Acute Lung Injury (2017)

Induced pluripotent stem cells (iPSCs) have been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration of intact cells faces many limitations. We hypothesized that cell-free conditioned media (CM) containing the secretome of iPSCs possess antioxidative constituents that can alleviate pulmonary oxidant stress damage. We derived iPSCs from human dermal fibroblasts and harvested the CM. Addition of iPSC CM to cultured human alveolar type-1 epithelial cells mitigated hyperoxia-induced depletion of endogenous total antioxidant capacity while tracheal instillation of iPSC CM into adult rat lungs enhanced hyperoxia-induced increase in TAC. In both the in vitro and in vivo models, iPSC CM ameliorated oxidative damage to DNA, lipid, and protein, and activated the nuclear factor (erythroid 2)-related factor 2 (Nrf2) network of endogenous antioxidant proteins. Compared with control fibroblast-conditioned or cell-free media, iPSC CM is highly enriched with αKlotho at a concentration up to more than 10-fold of that in normal serum. αKlotho is an essential antioxidative cell maintenance and protective factor and an activator of the Nrf2 network. Immunodepletion of αKlotho reduced iPSC CM-mediated cytoprotection by ∼50%. Thus, the abundant αKlotho content significantly contributes to iPSC-mediated antioxidation and cytoprotection. Results uncover a major mechanism of iPSC action, suggest a fundamental role of αKlotho in iPSC maintenance, and support the translational potential of airway delivery of cell-free iPSC secretome for protection against lung injury. The targeted cell-free secretome-based approach may also be applicable to the amelioration of injury in other organs. Stem Cells 2018;36:616-625.
A humanized single-chain Fv fragment with high targeting potential against human malignant gliomas. (1999)

A humanized ONS-M21 antibody (hM21) against human medulloblastoma and glioma cells was engineered as a single-chain Fv fragment (scFv), and its ability to internalize into tumor cells was evaluated by conjugation with ricin A. The scFv of hM21 (schM21) was easily purified from E.coli by one-step affinity column chromatography. Purified schM21 bound to a medulloblastoma ONS-76 cell with almost equal antigen-binding activity of hM21-Fab fragment. Furthermore, the schM21-ricin A conjugate inhibited the growth of ONS-76 cells, but not that of antigen-negative hepatoma HuH-7 cells, suggesting that the schM21 can be internalized after binding to antigen-positive cells. Thus, schM21 could be expected to act as a novel carrier of diagnostic and therapeutic agents for brain tumors.
Botulinum A Toxin Urethral Injection for the Treatment of Lower Urinary Tract Dysfunction (2003)

Botulinum A toxin urethral injections at doses of 50 or 100 units were effective in decreasing urethral sphincter resistance in patients with various types of lower urinary tract dysfunction.
Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic? (2020)

The results presented here demonstrate the nematicidal activity of ketamine in vitro and in vivo, thus confirming the nematicidal potential of the molecule present in the fungus P. chlamydosporia may consist of a new method of controlling parasites.
Activation of Pitressin by Acetic Acid. (1940)

Pitressin when boiled with acetic acid becomes more potent as shown by subcutaneous antidiuretic assay and intravenous pressor assay. These effects are not due to boiling, concentration, acidity, or the presence of acetate ions. The significance of these findings in connection with the preparation of acetic acid extracts of tissues for pitressin assay is discussed.
HabilisDraw DT (2004)

In this paper, we present a two-handed tool-based drawing environment based on the principles originally incorporated into the HabilisDraw interactive drawing system. These principles include persistent tools that embody intuitive aspects of their physical counterparts and an approach to interface learnability that capitalizes on the user's inherent ability to use tools both separately and in conjunction with other tools. In addition to these principles, the DiamondTouch variation of HabilisDraw (HabilisDraw DT) extends the physical-virtual tool correlation with bimanual input via the MERL DiamondTouch input device and a close adherence to the direct manipulation interaction model. This paper presents the HabilisDraw interface, explores the benefits of a desktop metaphor that closely mimics the behavior of two-dimensional tools and objects in a drawing environment, and argues for the applicability of the system's fundamental principles for improving interface usability in the future.
Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome (2019)

HPS patients displayed a multifaceted, systemic inflammatory response, with IL-6 and I-FABP as independent markers of disease severity and fatality, respectively.