gebhart/patrepeval huggingface dataset:
Towards linking perception research and image quality (1980)

Image quality as a general notion relates both to elementary and to complex visual functions. In this paper we deal with a few of them, which correspond to some lines of research at our Institute. We start with threshold predictions in time and space domains by means of elementary response functions, which have been recently developed considerably, although full generalization has not yet been achieved. As to suprathreshold stimuli, the responses of subjects usually have to be scaled. Here we deal with some problems connected with scaling techniques. After a brief discussion of the applicability of notions on visual conspicuity and visual search to image quality problems, we finally discuss reading from alphanumeric displays.
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity (1991)

We have characterized further the antioxidant responsive element (ARE) identified in the 5'-flanking region of the rat glutathione S-transferase Ya subunit gene and the NAD(P)H:quinone reductase gene by mutational and deletion analyses. Our data suggest that the sequence, 5'-puGTGACNNNGC-3' 3'-pyCACTGNNNCG-5' where N is any nucleotide, represents the core sequence of the ARE required for transcriptional activation by phenolic antioxidants and metabolizable planar aromatic compounds (e.g. beta-naphthoflavone and 3-methylcholanthrene). We also have found that the ARE is responsive to hydrogen peroxide and phenolic antioxidants that undergo redox cycling. These latter data suggest that the ARE is responsive to reactive oxygen species and thus may represent part of a signal transduction pathway that allow eukaryotic cells to sense and respond to oxidative stress.
An Efficient Synthesis of (+)-exo-Brevicomin via Chloroallylboration (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTAn Efficient Synthesis of (+)-exo-Brevicomin via ChloroallylborationShaojing Hu, Seetharaman Jayaraman, and Allan C. OehlschlagerView Author Information Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6 Cite this: J. Org. Chem. 1999, 64, 7, 2524–2526Publication Date (Web):March 5, 1999Publication History Received6 August 1998Published online5 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/jo981604chttps://doi.org/10.1021/jo981604cbrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views486Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Aldehydes,Cyclization,Inorganic carbon compounds,Organic polymers Get e-Alerts
Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18 (1995)

The beta 2-integrin (CD18) family members bind to their ligands subsequent to activation of a number of well defined and diverse signal transduction pathways. The precise molecular changes associated with activation of the integrin family members have remained elusive. Here, we characterize a monoclonal, CBR LFA-1/2, that binds to the beta 2-subunit and is able to mimic activation induced upon stimulation by phorbol esters. The Ab induces binding of the LFA-1-expressing cell line, JY, to ICAM-1 (CD54) and ICAM-3 (CD50). Activation of binding by this Ab is independent of Fc interactions and does not occur through cross-linking at the cell surface, because the Fab fragment of the Ab is able to modulate the same effect. Stimulation of neutrophils with CBR LFA-1/2 induces binding to ICAM-1 through activation of both LFA-1 and Mac-1. Activation of Mac-1 by CBR LFA-1/2 was further confirmed by stimulation of neutrophil binding to fibrinogen, a ligand for Mac-1. CBR LFA-1/2 lowers by 10-fold the concentration of Mg2+ required to achieve maximal binding of LFA-1 to ICAM-1. It therefore appears that CBR LFA-1/2 induces a conformational change that directly increases the avidity of beta 2-integrins for ligands.
Microwave synthesizer using an on-chip Brillouin oscillator (2013)

Low-phase-noise microwave oscillators are important to a wide range of subjects, including communications, radar and metrology. Photonic-based microwave-wave sources now provide record, close-to-carrier phase-noise performance, and compact sources using microcavities are available commercially. Photonics-based solutions address a challenging scaling problem in electronics, increasing attenuation with frequency. A second scaling challenge, however, is to maintain low phase noise in reduced form factor and even integrated systems. On this second front, there has been remarkable progress in the area of microcavity devices with large storage time (high optical quality factor). Here we report generation of highly coherent microwaves using a chip-based device that derives stability from high optical quality factor. The device has a record low electronic white-phase-noise floor for a microcavity-based oscillator and is used as the optical, voltage-controlled oscillator in the first demonstration of a photonic-based, microwave frequency synthesizer. The synthesizer performance is comparable to mid-range commercial devices.
Temporal partitioning and scheduling data flow graphs for reconfigurable computers (1999)

FPGA-based configurable computing machines are evolving rapidly. They offer the ability to deliver very high performance at a fraction of the cost when compared to supercomputers. The first generation of configurable computers (those with multiple FPGAs connected using a specific interconnect) used statically reconfigurable FPGAs. On these configurable computers, computations are performed by partitioning an entire task into spatially interconnected subtasks. Such configurable computers are used in logic emulation systems and for functional verification of hardware. In general, configurable computers provide the ability to reconfigure rapidly to any desired custom form. Hence, the available resources can be reused effectively to cut down the hardware costs and also improve the performance. In this paper, we introduce the concept of temporal partitioning to partition a task into temporally interconnected subtasks. Specifically, we present algorithms for temporal partitioning and scheduling data flow graphs for configurable computers. We are given a configurable computing unit (RPU) with a logic capacity of S/sub RPU/ and a computational task represented by an acyclic data flow graph G=(V, E). Computations with logic area requirements that exceed S/sub RPU/ cannot be completely mapped on a configurable computer (using traditional spatial mapping techniques). However, a temporal partitioning of the data flow graph followed by proper scheduling can facilitate the configurable computer based execution. Temporal partitioning of the data flow graph is a k-way partitioning of G=(V, E) such that each partitioned segment will not exceed S/sub RPU/ in its logic requirement. Scheduling assigns an execution order to the partitioned segments so as to ensure proper execution. Thus, for each segment in {s/sub 1/,s/sub 2/,...,s/sub k/}, scheduling assigns a unique ordering S/sub i/-j,1/spl les/i/spl les/k,1/spl les/j/spl les/k, such that the computation would execute in proper sequential order as defined by the flow graph G=(V, E).
Unilateral Cervicothoracic Sympathetic Ganglionectomy for the Treatment of Long QT Interval Syndrome (1971)

THE syndrome of congenital deafness, syncopal episodes, long QT interval on the electrocardiogram and sudden death has been well described.1 2 3 Recently, ventricular dysrhythmias have been documented as the cause of the syncope and sudden death in this condition.4 Although the original descriptions indicated that the syndrome was hereditable, sporadic, nonfamilial cases with and without associated deafness have been reported.5 The cause of the prolonged QT interval is poorly understood, but abnormalities in the central nervous system have been implicated.6 Effective antiarrhythmic therapy has been the subject of considerable interest since the prolonged QT interval contraindicates the use of most standard . . .
Development of the inner ear melanogenic system and the hearing function in the gerbil (Meriones unguiculatus). (1995)

Pérez, D.; Benedito, E.; Jiménez-Cervantes, C.; Ferrer, C.; Zuasti, A.; Solano, F.; Lozano, J.; Jiménez-Cervantes, J.; García-Borrón, J. C. Author Information
Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. (1993)

Progressive deposition of amyloid beta-protein (A beta) in brain parenchyma and blood vessels is a characteristic feature of Alzheimer disease. Recent evidence suggests that addition of solubilized synthetic A beta to medium may produce toxic or trophic effects on cultured hippocampal neurons. Because soluble A beta may not accumulate in significant quantities in brain, we asked whether immobilized A beta peptide as a substrate alters neurite outgrowth from cultured rat peripheral sensory neurons. This paradigm may closely mimic the conditions in Alzheimer disease brain tissue, in which neurites contact insoluble, extracellular aggregates of beta-amyloid. We detected no detrimental effects of A beta substrate on neurite outgrowth. Rather, A beta in combination with low doses of laminin or fibronectin enhanced neurite out-growth from these neuronal explants. Our results suggest that insoluble A beta in the cerebral neuropil may serve as a neurite-promoting matrix, perhaps explaining the apparent regenerative response of neurites observed around amyloid plaques in Alzheimer disease. Moreover, in concert with the recent discovery of A beta production by cultured neurons, our data suggest that A beta plays a normal physiological role in brain by complexing with the extracellular matrix.
The photochemistry of 3-ethoxy-3-methylpent-4-en-2-one, an .alpha.-alkoxy .beta.,.gamma.-unsaturated ketone (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe photochemistry of 3-ethoxy-3-methylpent-4-en-2-one, an .alpha.-alkoxy .beta.,.gamma.-unsaturated ketoneKenneth G. Hancock and Philip L. WylieCite this: J. Org. Chem. 1977, 42, 11, 1850–1856Publication Date (Print):May 1, 1977Publication History Published online1 May 2002Published inissue 1 May 1977https://pubs.acs.org/doi/10.1021/jo00431a006https://doi.org/10.1021/jo00431a006research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1 (1995)

Certain human immunodeficiency virus type 1 (HIV-1) isolates are able to productively infect nondividing cells of the monocyte/macrophage lineage. We have used a molecular genetic approach to construct two different HIV-1 integrase mutants that were studied in the context of an infectious, macrophage-tropic HIV-1 molecular clone. One mutant, HIV-1 delta D(35)E, containing a 37-residue deletion within the central, catalytic domain of integrase, was noninfectious in both peripheral blood mononuclear cells and monocyte-derived macrophages. The HIV-1 delta D(35)E mutant, however, exhibited defects in the assembly and/or release of progeny virions in transient transfection assays, as well as defects in entry and/or viral DNA synthesis during the early stages of monocyte-derived macrophage infection. The second mutant, HIV-1D116N/8, containing a single Asp-to-Asn substitution at the invariant Asp-116 residue of integrase, was also noninfectious in both peripheral blood mononuclear cells and monocyte-derived macrophages but, in contrast to HIV-1 delta D(35)E, was indistinguishable from wild-type virus in reverse transcriptase production. PCR analysis indicated that HIV-1D116N/8 entered monocyte-derived macrophages efficiently and reverse transcribed its RNA but was unable to complete its replication cycle because of a presumed block to integration. These data are consistent with the hypothesis that integration is an obligate step in productive HIV-1 infection of activated peripheral blood mononuclear cells and primary human macrophage cultures.
Pioglitazone ameliorates nonalcoholic steatohepatitis by down-regulating hepatic nuclear factor-kappa B and cyclooxygenases-2 expression in rats. (2012)

Down-regulating hepatic NF-κB and COX-2 expression, at least in part, is one of the possible therapeutic mechanisms of pioglitazone in NASH rats.
T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen‐activated protein kinase mechanism (2003)

These studies demonstrate for the first time that human osteoblasts produce MMP-13. The results also show that under conditions of chronic inflammation, multiple T cell cytokines synergize to induce high levels of MMP-13 via a mechanism that is dependent on activated p38 MAP kinase and is suppressed by activated ERK-1/2. Selective inhibition of p38 activity may offer a target for pharmacologic inhibition of bone loss in RA.
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood (2011)

Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. When suspended in human or animal plasma, staphylococci are known to agglutinate, however the bacterial factors responsible for agglutination and their possible contribution to disease pathogenesis have not yet been revealed. Using a mouse model for S. aureus sepsis, we report here that staphylococcal agglutination in blood was associated with a lethal outcome of this disease. Three secreted products of staphylococci--coagulase (Coa), von Willebrand factor binding protein (vWbp) and clumping factor (ClfA)--were required for agglutination. Coa and vWbp activate prothrombin to cleave fibrinogen, whereas ClfA allowed staphylococci to associate with the resulting fibrin cables. All three virulence genes promoted the formation of thromboembolic lesions in heart tissues. S. aureus agglutination could be disrupted and the lethal outcome of sepsis could be prevented by combining dabigatran-etexilate treatment, which blocked Coa and vWbp activity, with antibodies specific for ClfA. Together these results suggest that the combined administration of direct thrombin inhibitors and ClfA-antibodies that block S. aureus agglutination with fibrin may be useful for the prevention of staphylococcal sepsis in humans.
Angiopoietin-mediated endothelial P-selectin translocation: cell signaling mechanisms (2007)

Recently identified, angiopoietin-1 (Ang1) and -2 (Ang2) bind to the tyrosine kinase receptor Tie2 and contribute to orchestrate blood vessel formation during angiogenesis. Ang1 mediates vessel maturation and integrity by favoring the recruitment of pericytes and smooth muscle cells. Ang2, initially identified as a Tie2 antagonist, may under certain circumstances, induce Tie2 phosphorylation and biological activities. As inflammation exists in a mutually dependent association with angiogenesis, we sought to determine if Ang1 and/or Ang2 could modulate proinflammatory activities, namely P-selectin translocation, in bovine aortic endothelial cells (EC) and dissect the mechanisms implicated. P-selectin, an adhesion molecule found in the Weibel-Palade bodies of EC, is translocated rapidly to the cell surface upon EC activation during inflammatory processes. Herein, we report that Ang1 and Ang2 (1 nM) are capable of mediating a rapid Tie2 phosphorylation as well as a rapid and transient endothelial P-selectin translocation maximal within 7.5 min (125% and 100% increase, respectively, over control values). In addition, we demonstrate for the first time that angiopoietin-mediated endothelial P-selectin translocation is calcium-dependent and regulated through phospholipase C-gamma activation.
The case for a single-chip multiprocessor (1996)

Advances in IC processing allow for more microprocessor design options. The increasing gate density and cost of wires in advanced integrated circuit technologies require that we look for new ways to use their capabilities effectively. This paper shows that in advanced technologies it is possible to implement a single-chip multiprocessor in the same area as a wide issue superscalar processor. We find that for applications with little parallelism the performance of the two microarchitectures is comparable. For applications with large amounts of parallelism at both the fine and coarse grained levels, the multiprocessor microarchitecture outperforms the superscalar architecture by a significant margin. Single-chip multiprocessor architectures have the advantage in that they offer localized implementation of a high-clock rate processor for inherently sequential applications and low latency interprocessor communication for parallel applications.
Tau Aggregates and Tau Pathology (2008)

There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron. In other disorders, like Huntington disease, a protective role has been suggested for the aggregates of huntingtin. In this paper, we review the role of tau aggregation and hypothesize that tau aggregates could have an insufficient protective role in damaged neurons.
Synthesis of Goethite by Separation of the Nucleation and Growth Processes of Ferrihydrite Nanoparticles Using Microfluidics (2009)

Abstract Microfluidic synthesis is used to form nanoparticles by separate nucleation and growth processes using two microreactors (see picture) operating under different temperature and flow conditions. Ferrihydrite nanoparticles precipitated in the first microreactor are aged under continuous flow in a second microtubular reactor, leading to goethite nanoparticles. TMAOH=tetramethylammonium hydroxide. magnified image
The Tomato Never-ripe Locus Regulates Ethylene-Inducible Gene Expression and Is Linked to a Homolog of the Arabidopsis ETR1 Gene (1995)

Fruit ripening represents a complex system of genetic and hormonal regulation of eukaryotic development unique to plants. We are using tomato ripening mutants as tools to elucidate genetic components of ripening regulation and have recently demonstrated that the Never-ripe (Nr) mutant is insensitive to the plant growth regulator ethylene (M.B. Lanahan, H.-C. Yen, J.J. Giovannoni, H.J. Klee [1994] Plant Cell 6:521-530). We report here ethylene sensitivity over a range of concentrations in normal and Nr tomato seedlings and show that the Nr mutant retains residual sensitivity to as little as 1 part per million of ethylene. Analysis of ripening-related gene expression in normal and mutant ethylene-treated fruit demonstrates that Nr exerts its influence on development at least in part at the level of ethylene-inducible gene expression. We have additionally used cloned tomato and Arabidopsis sequences known to influence ethylene perception as restriction fragment length polymorphism probes, and have identified a tomato locus linked to Nr that hybridizes to the Arabidopsis ETR1 gene at low stringency, suggesting the possibility that Nr may be homologous to ETR1.
The discovery of natural products with therapeutic potential. (1994)

The source of Chemical Diversity Aerobic Actinomycetes: A Continuing Source of novel Natural Products, Bacterias a Source of Novel Therapeutics, The Potential of Fungi in the Discovery of Novel, Low Molecular Weight pharmaceuticals, Discover of Drugs from Higher Plants, The Discovery of Marine Natural Products with therapeutic Potential, New Targets for Screening Assays, Mechanism-Based Screening for the Discovery of Novel Antifungals, Strategies for Discovering Antiviral Agents from Natural Products, Mechanism - based Screens in the Discovery of Chemotherapeutic Antibacterials, Oncogene Function Inhibitors of Microbial Origin, Screening Methodologies for the Discovery of Novel Cytotoxic antitumor Agents, hypocholesterolemic Agents, Immunomodulators, Isolation and Structure Determination of Natural products Isolation and purification of Secondary Metabolities, Moderm Spectroscopic Approaches to Structural Eluicidation.
RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria (2007)

We are now aware that RNA-based regulatory mechanisms are commonly used to control gene expression in many organisms. These mechanisms offer the opportunity to exploit relatively short, unique RNA sequences, in altering transcription, translation, and/or mRNA stability, in response to the presence of a small or large signal molecule. The ability of an RNA segment to fold and form alternative hairpin secondary structures -- each dedicated to a different regulatory function -- permits selection of specific sequences that can affect transcription and/or translation. In the present paper I will focus on our current understanding of the RNA-based regulatory mechanisms used by Escherichia coli and Bacillus subtilis in controlling expression of the tryptophan biosynthetic operon. The regulatory mechanisms they use for this purpose differ, suggesting that these organisms, or their ancestors, adopted different strategies during their evolution. I will also describe the RNA-based mechanism used by E. coli in regulating expression of its operon responsible for tryptophan degradation, the tryptophanase operon.
Assessment of different permeabilization methods of minimizing damage to the adherent cells for detection of intracellular RNA by flow cytometry. (2014)

Our study indicated that the highest levels of mean fluorescence could be obtained when the cells were treated with Tween-20. However, it should be taken into consideration that for a successful flow cytometric result, other interfering factors such as hybridization conditions should also be optimized.