gebhart/patrepeval huggingface dataset:
Freeform lens arrays for off-axis illumination in an optical lithography system (2011)

We propose a method of designing a freeform lens array for off-axis illumination (OAI) in optical lithography to produce desired OAI patterns and improve efficiency. Based on the Snell law and the conservation law of energy, a set of first-order partial differential equations are derived and the coordinate relations for each OAI pattern are established. The contours of the freeform lens unit are calculated numerically by solving the partial differential equations, and the freeform lens array is obtained by arraying the lens units. Moreover, the optical performance for each OAI pattern is simulated and analyzed by software. Simulation results show that the irradiance distribution of each OAI pattern can be well controlled with a maximum uniformity of 92.45% and a maximum efficiency of 99.35%. Also, analysis indicates that this method has the advantages of reducing the complexity of the exposure system and having good tolerance to the input intensity variations of the laser beam.
Recent advances in graft‐versus‐host disease (GVHD) prevention (1997)

In the 1970s and 1980s, GVHD prevention approaches were limited in number. Recent advances in our understanding of the requirements for T-cell immune responses and for basic mechanism(s) involved in GVHD pathophysiology have led to exciting new strategies for GVHD prevention. This review focuses upon recent developments in GVHD prevention generated over the past 5 years. We have selected five different types of strategies to highlight including: 1) the in vivo targeting of GVHD-reactive T cells using either intact and F(ab')2 fragments of monoclonal antibodies directed against T-cell-surface determinants or immunotoxins which consist of antibodies linked to toxins, 2) a comparison of the in vivo immunosuppressive effects of FK506 and rapamycin on T-cell signaling, 3) the inhibition of T-cell activation through blockade of costimulatory or adhesogenic signals, 4) shifting the balance between acute GVHD-inducing T-helper-type 1 (Th1) T cells to anti-inflammatory T-helper-type 2 (Th2)-type T cells, and 5) the regulation of alloreactive T-cell activation by treatment with peptide analogs which affect either TCR/MHC, CD4/MHC class II, or CD8/MHC class I interactions. Collectively, these approaches are illustratrative of the progress made in extending our GVHD prevention armamentarium.
Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder (2013)

In naturally postmenopausal women with HSDD, flibanserin, compared with placebo, has been associated with improvement in sexual desire, improvement in the number of SSEs, and reduced distress associated with low sexual desire, and is well tolerated.
2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation (2011)

Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanthines as potent mechanism-based inactivators of MPO. Mass spectrometry and x-ray crystal structures revealed that these inhibitors become covalently attached to the heme prosthetic groups of the enzyme. We propose a mechanism whereby 2-thioxanthines are oxidized, and their incipient free radicals react with the heme groups of the enzyme before they can exit the active site. 2-Thioxanthines inhibited MPO in plasma and decreased protein chlorination in a mouse model of peritonitis. They slowed but did not prevent neutrophils from killing bacteria and were poor inhibitors of thyroid peroxidase. Our study shows that MPO is susceptible to the free radicals it generates, and this Achilles' heel of the enzyme can be exploited to block oxidative stress during inflammation.
Cleavage of Methyl Ethers of Flavones by Chloroaluminate Ionic Liquid (2004)

Abstract A new o‐demethylation method of a series of mono‐, di‐, trimethoxy‐flavones using a chloroaluminate ionic liquid—[BMIM] [Al2Cl7] in dichloromethane is described. The desired products were obtained in moderate to good yields.
Long Non-Coding RNAs and Complex Human Diseases (2013)

Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes, such as chromatin remodeling, gene transcription, and protein transport and trafficking. Moreover, lncRNAs are dysregulated in a number of complex human diseases, including coronary artery diseases, autoimmune diseases, neurological disorders, and various cancers, which indicates their important roles in these diseases. Here, we reviewed the current understanding of lncRNAs, including their definition and subclassification, regulatory functions, and potential roles in different types of complex human diseases.
EVALUATION ON ONLINE LEARNING RESOURCES BASED ON CUSTOMER SATISFACTION (2020)

In recent years, lifelong education has become widespread in the public, contributing to explosive development of modern distance education. Meanwhile, distance learners have gradually had more and higher demands for online learning resources. Despite abundant online learning resources at present, their overall quality is relatively low and they can hardly satisfy learners’ learning demands. Based on customer satisfaction, the essay establishes evaluation indexes about online learning resources based on customer satisfaction, improves its development and proposes suggestions for improvement, which is of great theoretical and practical significance.
In vitro interaction of astrocytes and pericytes with capillary-like structures of brain microvessel endothelium. (1991)

A new method to study the interaction of astrocytes and pericytes with cerebral capillary endothelial cells in vitro is described. Endothelial cells derived from bovine brain were cultured on gelatin coated slides and covered with type 1 collagen. Endothelial cells aggregated and formed capillary-like structures (CS) within 3 days. The lining cells of the CS stained immunohistochemically for factor VIII-related antigen. Astrocytes isolated from neonatal mice or pericytes from bovine brain were added to the preparations after the formation of CS. After various periods of co-culture, the slides were fixed with methanol and examined with the immunohistochemical stain for glial fibrillary acidic protein or smooth muscle actin to demonstrate astrocytes or pericytes respectively. Five hours after addition, only 10% of astrocytes were associated with CS. However, by 24 hours, 70% of the astrocytes had assumed a position adjacent to the CS. The astrocytes then developed processes which were intimately apposed to the CS by 3 days, at which time they resembled the in vivo structural relationship between astrocytes and microvessels that occur in areas of central nervous system injury. Progressive elongation of the astrocytes or their processes at the CS was evident at 6 and 9 days of co-culture. The cross-section of CS co-cultured with astrocytes showed continuous cells surrounding a lumen, and the endothelial cells appeared to be connected by tight junctions. When pericytes were added to CS cultures they also preferentially associated with CS, but the contact occurred more rapidly than with astrocytes, 50% being associated with CS by 5 hours. The CS were almost completely covered with elongated pericytes by 24 hours. A chemotactic assay was developed that showed that there was a chemotactic attraction of pericytes to the CS. Thus an in vitro system is now available to study the interrelationships of these cell types and their interaction in development, regeneration and differentiation of the blood-brain barrier.
Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture (1991)

We have examined the effects of 10 different growth factors either alone or in combination on colony-forming unit-spleen (CFU-S) and repopulating stem cell survival in vitro. Either interleukin-3 (IL-3), granulocyte-colony-stimulating factor (G-CSF), or IL-4 alone support CFU-S in vitro. The effects of IL-3 or G-CSF could be neutralized by adding antibodies against IL-3 or G-CSF, respectively. However, the effects of IL-4 could be neutralized with antibodies to IL-4 as well as with antibodies to IL-3 and G-CSF. The combinations of IL-3 and IL-6, IL-3 and G-CSF, IL-3 and IL-1 alpha, IL-3 and granulocyte-macrophage CSF (GM-CSF), and IL-4 and IL-6 acted synergistically to increase CFU-S number. Addition of macrophage inflammatory protein-1 alpha (MIP-1 alpha) to IL-3 and IL-6 inhibited the increase in CFU-S number. Repopulating stem cell function was measured in a competitive repopulation assay. Either IL-3 or IL-4 alone could preserve stem cell function in vitro. The combinations of IL-3 and IL-6, and IL-3 and G- CSF increased stem cell function approximately twofold. The combinations of IL-3 + G-CSF + IL-6, and IL-4 and IL-6 (both of which increased CFU-S number fivefold to 10-fold) decreased stem cell function approximately fourfold. These results demonstrate that certain combinations of growth factors can increase CFU-S number at the expense of stem cell function.
Voltage Scalable Switched Capacitor DC-DC Converter for Ultra-Low-Power On-Chip Applications (2007)

This paper presents a voltage scalable switched capacitor (SC) DC-DC converter which employs on-chip charge- transfer capacitors. The DC-DC converter makes use of multiple topologies to achieve scalable voltage generation while minimizing conduction loss and a technique called divide-by-3 switching to minimize the loss due to bottom-plate parasitics. It also uses automatic frequency scaling to reduce switching losses. The converter employs an all digital control which consumes no static power. The voltage scalable SC DC-DC converter with integrated on-chip charge-transfer capacitors was implemented in a 0.18μm CMOS process and achieves above 70% efficiency over a wide range of load powers from 5μW to 1mW, while delivering load voltages from 300mV to 1.1V. The active area consumed by the converter is 0.57mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Structure and Organization of Hemolytic and Nonhemolytic Diastereomers of Antimicrobial Peptides in Membranes (1999)

Recently, we reported on a new group of diastereomers of short-model peptides (12 amino acids long) composed of leucine and lysine with varying ratios, possessing several properties that make them potentially better than native or de novo-designed all L-amino acid antimicrobial peptides. Preliminary studies have revealed that modulating the hydrophobicity and positive charges of these diastereomers is sufficient to confer antibacterial activity and cell selectivity. However, the relationship between their biological function, structure, and mode of action was not investigated. Here we synthesized and investigated three types of linear model diastereomers (12 amino acids long) with varying lysine:leucine (or tryptophan) ratios (i.e., K(3)L(8)W, K(5)L(6)W, and K(7)L(4)W), which confer different levels of lytic activities. For each K:L ratio, tryptophan was introduced in the middle or the N- or C-terminus of the peptides, as an intrinsic fluorescent probe. Only the hemolytic peptide K(3)L(8)W binds to both negatively charged and zwitterionic phospholipid membranes. K(5)L(6)W and K(7)L(4)W bind similarly, but only to negatively charged membranes, despite the fact that K(5)L(6)W is substantially more lytic to bacteria than K(7)L(4)W. Interestingly, although K(3)L(8)W contains 33% D-amino acids, ATR-FTIR spectroscopy revealed a structure of approximately 90% alpha-helix in both types of membranes. In addition, K(5)L(6)W contains approximately 40% 3(10)-helix and K(7)L(4)W is predominantly a random coil in membranes. Polarized ATR-FTIR and tryptophan-quenching experiments, using brominated phospholipids, revealed a similar depth of penetration and an orientation that was parallel to the membrane surface for all the peptides, but with K(3)L(8)W affecting the lipid order more than the others. The results provide insight into the mode of action of this group of diastereomeric peptides, and the effect of hydrophobicity and positive charges on their membrane structure, function, and cell selectivity. Moreover, this research should assist in the development of suitable diastereomeric peptide antibiotics for therapeutic use that would overcome the problem the increasing resistance of bacteria to conventional antibiotics.
Suppressive Effects Of Oxcarbazepine On Tooth Pulp‐Evoked Potentials Recorded At The Trigeminal Spinal Tract Nucleus In Cats (2001)

1. The purpose of the present study was to evaluate the antinociceptive effect of oxcarbazepine, a keto derivitive of carbamazepine (an anticonvulsant), in an animal model. To evoke a nociceptive response, we electrically stimulated the maxillary canine tooth pulp (MCTP) in anaesthetized (allobarbital-urethane), spontaneously breathing cats. 2. The evoked potentials were recorded from the superficial layers of the caudal part of the trigeminal spinal tract nucleus (5ST). We examined a slow component with a large amplitude (the P3 component) in evoked compound potentials; its mean conduction velocity was 1.7 m/s, suggesting a response mediated by C-fibres. 3. To confirm that the P3 component was related to pain sensation, we used morphine, a most efficacious antinociceptive agent, in the present study. The P3 component was significantly suppressed by intravenous administration of morphine (3 mg/kg) and was also suppressed by microinjection of morphine (2 microg) into the recording site of the 5ST. These results suggest that the P3 component is involved in the transmission of nociceptive information. 4. We compared the effect of oxcarbazepine with mexiletine; both are known to block neuronal Na+ channels. Intravenous administration of mexiletine suppressed the P3 component at a dose of 5 mg/kg. Microinjection of mexiletine (10 microg) into the recording site of the 5ST tended to suppress the P3 component, but this effect was not significant. 5. Intravenous administration of oxcarbazepine (1-10 mg/kg) caused a dose-dependent inhibition of the P3 component, which was significantly suppressed at 10 mg/kg oxcarbazepine. Intravenous administration of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide (MHD), a metabolite of oxcarbazepine, at doses of 3-30 mg/kg caused a dose-dependent inhibition of the P3 component. Oxcarbazepine was not available for the microinjection study because it is not water soluble. We used MHD for the microinjection study instead of oxcarbazepine, because MHD can be dissolved in water up to 3 mg/mL. Microinjections of MHD (6 microg) into the recording site of the 5ST suppressed the P3 component. These results indicate that oxcarbazepine has an antinociceptive action.
Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. (1989)

We introduced a mouse IL-2 cDNA expression vector into an IL-2-dependent mouse helper T cell line HT-2. Transfected cells secreted substantial amounts of IL-2, to which they themselves responded by proliferating without further requirement for exogenous IL-2. The proliferation was a direct function of the cell density and was inhibitable by antibodies against IL-2 or IL-2-R, indicating the autocrine nature of the proliferation. Those producing higher amounts of IL-2 were found to be tumorigenic when inoculated into nude mice. The latency period of tumor development correlated inversely with the level of IL-2 secreted. Tumor cells proliferated in vitro in an IL-2 autocrine fashion indistinguishable from that of the inoculated cells. We thus provide evidence that the aberrant activation of the IL-2 autocrine circuit can lead T cells to malignant transformation.
Micro‐ and Nano‐ Magnetic Particles for Applications in Biosensing (2007)

Abstract This article reviews the development of electrochemical biosensors, incorporating magnetic particles, for detecting biomolecules (nucleic acids and proteins) and cells. Magnetic particles (MPs) of micro‐ and nanoscale, mimicking the size of molecules in nature, possess interesting characteristics that facilitate the purification and detection of biomolecules in a wide range of samples. In particular, the high surface area and the paramagnetic or superparamagnetic properties of these tiny particles provide an attractive technology platform for the design of electrochemical biosensors. Examples of electrochemistry‐based approaches to achieve the separation and detection of bioentities utilizing MPs are described. Emphasis is placed on the strategies to incorporate the electrochemical labels to the MPs and the methods to achieve the dual function of electrochemical detection and magnetic separation. The protocols to make MPs as labels in biological sensors are also discussed.
Micellization of Two Triquaternary Ammonium Surfactants in Aqueous Solution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicellization of Two Triquaternary Ammonium Surfactants in Aqueous SolutionR. Zana, H. Levy, D. Papoutsi, and G. BeinertCite this: Langmuir 1995, 11, 10, 3694–3698Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/la00010a018https://doi.org/10.1021/la00010a018research-articleACS PublicationsRequest reuse permissionsArticle Views990Altmetric-Citations147LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
VPModel: High-Fidelity Product Simulation in a Virtual-Physical Environment (2019)

In the development of a new product, the design team must describe the expected effects of the final products to potential users and stakeholders. However, existing prototyping tools can only present a product imperfectly, due to limitations at different levels. Specifically, the physical product model, which may be the product of 3D printing, could lack a visual interface; the presentation of the product through modeling software such as Rhinoceros 3D does not provide good realistic tactile perception; or the interface platforms, such as Axure RP, used to display the interactive effects differ from those to be used in the actual operation. Thus, we present the VPModel, a high-fidelity prototyping tool, able to integrate multiple prototyping methods simultaneously. It combines a touchable 3D-printed product model (3DPM) and a corresponding visualized virtual model, and the interactive interfaces are rendered synchronously in a mixed-reality device. Through the tangible, visual, and interactive demonstration, designers and normal users can each obtain a similar experience to the experience of the finished product. Furthermore, the VPModel also enhances design practices by enabling comparisons between modular models. However, the implementation of this system is a challenging task, which subsumes several fundamental problems as sub-tasks: object detection, real-time matching, hand-gesture detection and action recognition. To achieve the expected goals of the VPModel, this system uses physical hardware (a Microsoft MR HoloLens headset, a Leap Motion Controller, and a 3D printer) and existing machine learning algorithms. To evaluate our VPModel, we report the user experience of 16 participants, evaluated using a closed-ended questionnaire survey, a quantitative analysis of task performance, and a qualitative analysis of open-ended interviews. The results show a significant improvement in realism and enjoyment using the VPModel over the two traditional camera prototype approaches. In summary, the VPModel can be used to support design strategy and to convey design concepts fully and efficiently, which indicates a potential use for the VPModel in shortening product development cycles and reducing communication costs.
Small-bore hollow waveguide for delivery of nearsinglemode IR laser radiation (1994)

A hollow waveguide whose bore size is 250 µm in diameter is fabricated by depositing a dielectric and a metal layer inside a thin-wall silica tube. This small bore waveguide has an advantage over the larger bore guides in that it maintains a nearly pure HE11 mode of a CO2 laser even when it is bent to small radii.
Characterization of experimental textured ZnO:Al films for thin film solar cell applications and comparison with commercial and plasmonic alternatives (2010)

We present the comprehensive characterization of several experimental ZnO:Al films for thin film solar cell applications. The morphological and optical properties of these films are determined using traditional and new, experimental measurement techniques and results are compared to those of the commercial Asahi U-type TCO as well as samples of planar TCOs coated in silver nanoparticles. Results show that the textured ZnO:Al films provide far superior scattering to the commercial alternatives studied. Nanoparticle coated planar TCOs also show scattering enhancement with results suggesting that nanoparticle layers could be tuned to predominantly scatter light within a chosen wavelength range.
Aqueous Sodium Hydroxide Promoted Cross-Coupling Reactions of Alkenyltrialkoxysilanes under Ligand-Free Conditions (2008)

Fluoride-free cross-coupling reactions of alkenyltrialkoxysilanes with aryl iodides, bromides, and chlorides are performed on water using sodium hydroxide as activator at 120 degrees C under normal or microwave heating. This process occurs in the presence of Pd(OAc)(2) or 4-hydroxyacetophenone oxime-derived palladacycle 1 as precatalysts under ligand-free conditions with low Pd loadings (0.01-1 mol %) and using tetra-n-butylammonium bromide as additive. Different commercially available vinylalkoxylsilanes can be cross-coupled under these reaction conditions to the corresponding styrenes, the best substrates being vinyltrimethoxy- or vinyltriethoxysilane. Alkenyltriethoxysilanes, prepared by Wilkinson-catalyzed hydrosilylation of alkynes with triethoxysilane, are stereospecifically arylated with aryl and vinyl halides under microwave irradiation in moderate to high beta/alpha regioselectivity affording unsymmetrical stilbenes, alkenylbenzenes, and conjugate dienes, respectively. This simple procedure allows the palladium recycling from the aqueous phase during three runs by extractive separation of the products, which contain very low levels of Pd (21-27.5 ppm for an aryl iodide and up to 76 ppm for a bromide).