gebhart/patrepeval huggingface dataset:
Preparation and chemical properties of soluble π‐conjugated poly(aryleneethynylene) consisting of azabenzothiadiazole as the electron‐accepting unit (2008)

Abstract A soluble charge‐transfer type poly(aryleneethynylene), PAE‐AzaBzTdz , consisting of a highly electron‐accepting azabenzothiadiazole unit was prepared in 99% yield by palladium‐catalyzed polycondensation between 4,7‐dibromo‐2,1,3‐azabenzothiadiazole ( Br 2 ‐AzaBzTdz ) and 1,4‐diethynyl‐2,5‐didodecyloxybenzene. PAE‐AzaBzTdz showed a number‐average molecular weight, M n , of 6000 in gel‐permeation chromatography analysis and had good thermal stability as measured by TGA. UV–vis spectrum of PAE‐AzaBzTdz exhibited an absorption peak at 529 nm in chloroform, and the absorption peak shifted to a longer wavelength (601 nm) in film. Addition of MeOH to a CHCl 3 solution of PAE‐AzaBzTdz led to aggregation of the polymer to form stable colloidal particles. Results of filtration experiments using 0.2 and 0.02 μm membranes supported aggregation of the polymer. Addition of trifluoroacetic acid (TFA) to a chloroform solution of PAE‐AzaBzTdz led to a red‐shift of the UV–vis peak from 529 to 640 nm. An X‐ray diffraction pattern of powdery PAE‐AzaBzTdz indicated that the polymer assumed a layer‐to‐layer stacked structure with an interlayer distance of 3.4 Å in the solid state. An X‐ray diffraction pattern of cast film of PAE‐AzaBzTdz revealed that the polymer molecules in the cast film were ordered on the surface of Pt plate with the dodecyl side chain oriented toward the surface of the Pt plate. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2975–2982, 2008
Bacterial Translocation of the Gut Flora (1990)

The Journal of Trauma: Injury, Infection, and Critical Care: December 1990 - Volume 30 - Issue - p 184
Heterodimeric Amino Acid Transporters: Molecular Biology and Pathological and Pharmacological Relevance (2001)

In the last decade, a lot of amino acid transporters were identified by molecular cloning and assigned to the classically characterized amino acid transport systems. Among them, ones which belong to the heterodimeric amino acid transporter family are unique because of their broad substrate selectivity and their pathological implications as well as their structural features. The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters as well as 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning type II membrane glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT (related to b(0,+)-amino acid transporter). Six members are associated with 4F2hc and one is linked to rBAT. The neutral amino acid transporter of this family seems to rely on the hydrophobic interactions for their substrate recognition which can explain their broad substrate selectivity. Because of this characteristic, they can permeate amino-acid-related drugs and contribute to the pharmacokinetics of these drugs. A neutral amino acid transporter LAT1 (L-type amino acid transporter 1) has actually been shown to be present at the blood-brain-barrier. Because the members of the heterodimeric amino acid transporter family exhibit variety of substrate selectivity, it is proposed that this family members have been diverged from the prototype neutral amino acid transporter such as LAT1 by acquiring the mechanisms for the recognition of electric charges on the substrate amino acid side chains. The dysfunction or hyperfunction of the members of the heterodimeric amino acid transporter family are involved in some diseases and pathologic conditions. The genetic defects of the renal and intestinal transporters BAT1/b(0,+) AT (b(0,+)-type amino acid transporter 1/b(0,+)-type amino acid transporter) and y+ LAT1 (y+ L-type amino acid transporter 1) result in the amino aciduria with sever clinical symptoms such as cystinuria and lysinuric protein intolerance, respectively. LAT1 is proposed to be involved in the progression of malignant tumor. xCT (x- C-type transporter) functions to protect cells against oxidative stress, while its over-function may be damaging neurons leading to the exacerbation of brain damage after, brain ischemia. Therefore, these transporters would be candidates for therapeutic targets based on new strategies. Through the interaction with the associating proteins, the transporters of this family would be endowed with more possibility to be regulated via intracellular and extracellular signalling pathways, which is critical to tune the transporter functions to meet the metabolic requirements of cells.
Einführung: Anatomie und Funktion des dopaminergen Verstärkungssystems (2000)

Das„dopaminerge Verstärkungssystem“ istein entwicklungsgeschichtlich altes System, das durch sogenannte „primäre Verstärker“ wie Essen, Trinken, sexuelle Aktivität und elterliches Fürsorgeverhalten angesprochen wird. Seine ausgeprägten Verstärkerwirkungen werden darauf zurückgeführt, dass es durch überlebenswichtige, mit der Nahrungsaufnahme oder Sexualität verbundene Reize aktiviert wird und so das Überleben der Art sichert (Ploog, 1990; Robbins und Everitt, 1996). Das Konzept der Verhaltensverstärkung lässt sich auf Skinner (1935) zurückfI Kren, der postulierte, dass eine Handlung immer dann gehäuft auftritt, wenn sie „positiv verstärkt“ wird. Skinner vermied es bewusst, eine positiveVerstärkung(„positive reinforcement“) mit psychologischen Konstrukten wie einer gehobenen Stimmung oder einem Lusterleben in Verbindung zu bringen. Bei der Verwendung behavioristischer Begriffe in der Suchtforschung wurde diese Trennung jedoch nicht immer aufrechterhalten, so dass die positive Verhaltensverstärkung oft alsBelohnung(„reward“) bezeichnet wurde, der eine affektiv positive, „hedonistische“ Wirkung zugeschrieben wurde (Di Chiara, 1995; Koob und Le Moal, 1997). Eine solche Redeweise identifiziert jedoch den deskriptiven Begriff der „Verhaltensverstärkung“ vorschnell mit nur einer der möglichen Ursachen verstärkt auftretender Verhaltensweisen, nämlich ihrer Belohnung in Form affektiv angenehmer Zustände. Im Folgenden soll deshalb der Begriff derVerstärkungverwandt werden, wenn von einer erhöhten Auftretenswahrscheinlichkeit bestimmter Verhaltensweisen gesprochen wird. Auch dieser Begriff ist nicht unzweideutig, da das neurobiologische System, das entscheidend an der Vermittlung derverhaltensverstärkendenWirkung bestimmter Umweltreize beteiligt ist, das sogenannte „dopaminerge Verstärkungssystem“, möglicherweise auch zurVerstärkung der neuronalen Reizüberleitung und Reizverarbeitungbeiträgt (Daniel et al., 1991; Cohen und Servan-Schreiber, 1992).
Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking (2001)

Carboxypeptidase D (CPD) is a transmembrane protein that processes proteins in the trans-Golgi network (TGN). A 20-residue region within the cytoplasmic tail of CPD binds protein phosphatase 2A (PP2A). PP2A also binds to the cytoplasmic tails of other secretory pathway proteins: peptidylglycine-(amino)-amidating mono-oxygenase, the cation-independent mannose-6-phosphate receptor and TGN38. The CPD tail is phosphorylated on Thr residues in the AtT-20 cell line. The CPD tail can also be phosphorylated by purified protein kinase A, protein kinase C and casein kinase II. Both the in vitro and the in vivo phosphorylated CPD tail can be dephosphorylated by purified PP2A. The binding of CPD tail peptide to PP2A does not influence phosphatase activity. The rate of transport of CPD from the TGN to the cell surface of AtT-20 cells is decreased 45% by okadaic acid, a PP2A inhibitor. Microinjection of the CPD tail into AtT-20 cells inhibits the transition of CPD from endosomal compartments to the TGN. However, okadaic acid does not affect the rate of budding of CPD from the TGN into nascent vesicles or the rate of uptake from the cell surface into endosomal compartments. These results are consistent with the model that PP2A is involved in the trafficking of proteins between a TGN recycling loop and a cell-surface recycling loop, but is not involved in the individual recycling loops.
Kinetics and native and modified liver alcohol dehydrogenase with coenzyme analogs: isomerization of enzyme-nicotinamide adenine dinucleotide complex (1986)

Coenzyme analogues with the adenosine ribose replaced with n-propyl, n-butyl, and n-pentyl groups; coenzyme analogues with the adenosine replaced with 3-(4-acetylanilino)propyl and 6-(4-acetylanilino)hexyl moieties; and nicotinamide mononucleotide, nicotinamide hypoxanthine dinucleotide, and 3-acetylpyridine adenine dinucleotide were used in steady-state kinetic studies with native and activated, amidinated enzymes. The Michaelis and inhibition constants increased up to 100-fold upon modification of coenzyme or enzyme. Turnover numbers with NAD+ and ethanol increased in some cases up to 10-fold due to increased rates of dissociation of enzyme-reduced coenzyme complexes. Rates of dissociation of oxidized coenzyme appeared to be mostly unaffected, but the values calculated (10-60 s-1) were significantly less than the turnover numbers with acetaldehyde and reduced coenzyme (20-900 s-1, at pH 8, 25 degrees C). Rates of association of coenzyme analogues also decreased up to 100-fold. When Lys-228 in the adenosine binding site was picolinimidylated, turnover numbers increased about 10-fold with NAD(H). Furthermore, the pH dependencies for association and dissociation of NAD+ and turnover number with NAD+ and ethanol showed the fastest rates above a pK value of 8.0. Turnover with NADH and acetaldehyde was fastest below a pK value of 8.1. These results can be explained by a mechanism in which isomerization of the enzyme-NAD+ complex (110 s-1) is partially rate limiting in turnover with NAD+ and ethanol (60 s-1) and is controlled by ionization of the hydrogen-bonded system that includes the water ligated to the catalytic zinc and the imidazole group of His-51.
Inkjet Printing—Process and Its Applications (2009)

In this Progress Report we provide an update on recent developments in inkjet printing technology and its applications, which include organic thin-film transistors, light-emitting diodes, solar cells, conductive structures, memory devices, sensors, and biological/pharmaceutical tasks. Various classes of materials and device types are in turn examined and an opinion is offered about the nature of the progress that has been achieved.
Directed diffusion (2000)

Advances in processor, memory and radio technology will enable small and cheap nodes capable of sensing, communication and computation. Networks of such nodes can coordinate to perform distributed sensing of environmental phenomena. In this paper, we explore the directed diffusion paradigm for such coordination. Directed diffusion is datacentric in that all communication is for named data. All nodes in a directed diffusion-based network are application-aware. This enables diffusion to achieve energy savings by selecting empirically good paths and by caching and processing data in-network. We explore and evaluate the use of directed diffusion for a simple remote-surveillance sensor network.
Plane-Casting (2013)

We present Plane-Casting, a novel technique for 3D object manipulation from a distance that is especially suitable for smarphones. We describe two variations of Plane-Casting and present results from a pilot study. Our evaluation demonstrates the feasibility of the interface and suggests that Pivot Plane-Casting is more suitable for quick, coarse movements whereas Free Plane-Casting is more suited to slower, precise motion. In a 3D movement task subjects preferred Free Plane-Casting overall among the two techniques.
Motion-tolerant magnetic earring sensor and wireless earpiece for wearable photoplethysmography (2010)

This paper addresses the design considerations and critical evaluation of a novel embodiment for wearable photoplethysmography (PPG) comprising a magnetic earring sensor and wireless earpiece. The miniaturized sensor can be worn comfortably on the earlobe and contains an embedded accelerometer to provide motion reference for adaptive noise cancellation. The compact wireless earpiece provides analog signal conditioning and acts as a data-forwarding device via a radio frequency transceiver. Using Bland-Altman and correlation analysis, we evaluated the performance of the proposed system against an FDA-approved ECG measurement device during daily activities. The mean +/- standard deviation (SD) of the differences between heart rate measurements from the proposed device and ECG (expressed as percentage of the average between the two techniques) along with the 95% limits of agreement (LOA = +/-1.96 SD) was 0.62% +/- 4.51% (LOA = -8.23% and 9.46%), -0.49% +/- 8.65% (-17.39% and 16.42%), and -0.32% +/- 10.63% (-21.15% and 20.52%) during standing, walking, and running, respectively. Linear regression indicated a high correlation between the two measurements across the three evaluated conditions (r = 0.97, 0.82, and 0.76, respectively with p < 0.001). The new earring PPG system provides a platform for comfortable, robust, unobtrusive, and discreet monitoring of cardiovascular function.
Synthesis of Pimelic Acid and α-Substituted Pimelic Acid and Intermediates1 (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Pimelic Acid and α-Substituted Pimelic Acid and Intermediates1Donald T. Warner and Owen A. MoeCite this: J. Am. Chem. Soc. 1952, 74, 2, 371–373Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/ja01122a024https://doi.org/10.1021/ja01122a024research-articleACS PublicationsRequest reuse permissionsArticle Views135Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Selective Small Molecule Inhibitor of c-Met, PHA665752, Inhibits Tumorigenicity and Angiogenesis in Mouse Lung Cancer Xenografts (2007)

The c-Met receptor tyrosine kinase is emerging as a novel target in many solid tumors, including lung cancer. PHA-665752 was identified as a small molecule, ATP competitive inhibitor of the catalytic activity of the c-Met kinase. Here, we show that treatment with PHA665752 reduced NCI-H69 (small cell lung cancer) and NCI-H441 (non-small cell lung cancer) tumorigenicity in mouse xenografts by 99% and 75%, respectively. Reduction in tumor size was also observed by magnetic resonance imaging of tumors in mice. PHA665752 inhibited c-Met phosphorylation at the autophosphorylation and c-Cbl binding sites in mouse xenografts derived from non-small cell lung cancer cell lines (NCI-H441 and A549) and small cell lung cancer cell line (NCI-H69). PHA665752 also inhibited angiogenesis by >85% in all the abovementioned cell lines and caused an angiogenic switch which resulted in a decreased production of vascular endothelial growth factor and an increase in the production of the angiogenesis inhibitor thrombospondin-1. These studies show the feasibility of selectively targeting c-Met with ATP competitive small molecule inhibitors and suggest that PHA665752 may provide a novel therapeutic approach to lung cancer.
Secure and resilient peer-to-peer e-mail design and implementation (2004)

E-mail is a mission-critical communication function for virtually all institutions. Modern e-mail employs a server-centric design, in which the user is critically dependent on her mail server. We present a peer-to-peer (P2P) email architecture that eliminates the need to rely on a single server and boosts the resilience of email against any kinds of attacks. Our architecture also provides confidential communications for all users. We present how the basic mechanisms of sending and reading email are implemented in our architecture. We also consider additional schemes to improve anonymity in our architecture. We present our prototype implementation and discuss the future of P2P communication architectures.
Performance of planar-waveguide external cavity laser for precision measurements (2010)

A 1542-nm planar-waveguide external cavity laser (PW-ECL) is shown to have a sufficiently low level of noise to be suitable for precision measurement applications. Its frequency noise and intensity noise was comparable or better than the non-planar ring oscillator (NPRO) and fiber laser between 0.1 mHz to 100 kHz. Controllability of the PW-ECL was demonstrated by stabilizing its frequency to acetylene ((13)C(2)H(2)) at 10(-13) level of Allan deviation. The PW-ECL also has the advantage of the compactness of a standard butterfly package, low cost, and a simple design consisting of a semiconductor gain media coupled to a planar-waveguide Bragg reflector.
Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas (2012)

We describe the use of novel bispecific hexavalent Abs (HexAbs) to enhance anticancer immunotherapy. Two bispecific HexAbs [IgG-(Fab)(4) constructed from veltuzumab (anti-CD20 IgG) and milatuzumab (anti-CD74 IgG)] show enhanced cytotoxicity in mantle cell lymphoma (MCL) and other lymphoma/leukemia cell lines, as well as patient tumor samples, without a crosslinking Ab, compared with their parental mAb counterparts, alone or in combination. The bispecific HexAbs have different properties from and are more potent than their parental mAbs in vitro. The juxtaposition of CD20 and CD74 on MCL cells by the HexAbs resulted in homotypic adhesion and triggered intracellular changes that include loss of mitochondrial transmembrane potential, production of reactive oxygen species, rapid and sustained phosphorylation of ERKs and JNK, down-regulation of pAkt and Bcl-xL, actin reorganization, and lysosomal membrane permeabilization, culminating in cell death. They also displayed different potencies in depleting lymphoma cells and normal B cells from whole blood ex vivo and significantly extended the survival of nude mice bearing MCL xenografts in a dose-dependent manner, thus indicating stability and antitumor activity in vivo. Such bispecific HexAbs may constitute a new class of therapeutic agents for improved cancer immunotherapy, as shown here for MCL and other CD20(+)/CD74(+) malignancies.
Role of natriuretic peptide signaling in modulating asthma and inflammationThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research. (2007)

Atrial natriuretic peptide (ANP), the C-terminal peptide comprising residues 99-126 of the pro-ANP hormone, has been studied for 3 decades for its cardiovascular effects. Recent reports suggest that it plays a significant role in modulation of the immune system. Immune cells, including macrophages, dendritic cells, and T lymphocytes, express receptors for ANP. ANP plays a significant role in shaping the early immune response to environmental antigens and may play a critical role in the interaction between cells of the innate and adaptive immune systems; it also appears to be involved in polarizing the immune response to allergens. Thus, ability to alter the magnitude of natriuretic peptide receptor A (NPRA) signaling could be exploited to develop therapeutics for several allergic diseases, including asthma. This report will review and critically evaluate the role of the ANP pathway in asthma and inflammation.
Percutaneous Nucleotomy (1991)

Fifteen cadaveric dissections have been performed to determine the anatomic relationships of nucleotomy guide wires. All the 44 guide wires inserted were found to be in contact with at least one nerve root (eight transfixed a root). Guide wires passing anterior to the nerve roots always passed anterior to the center of the disc. Lateral displacement of the skin entry point made safe entry to the center of the disc impossible. Nerve root transfixion is likely to be a significant complication in percutaneous nucleotomy. Entry to the center of the disc avoiding the nerve roots is simplest if the skin entry is as near to the midline as possible.
Acceleration and Trapping of Particles by Radiation Pressure (1970)

Micron-sized particles have been accelerated and trapped in stable optical potential wells using only the force of radiation pressure from a continuous laser. It is hypothesized that similar accelerations and trapping are possible with atoms and molecules using laser light tuned to specific optical transitions. The implications for isotope separation and other applications of physical interest are discussed.
Glypican-3 Expression in Wilms Tumor and Hepatoblastoma (2001)

Increased expression of GPC3 in Wilms tumor and hepatoblastoma suggests a growth-promoting or neutral activity for this gene product rather than a growth-suppressive effect.
Secure quantum key distribution (2014)

An overview is given of the state-of-the-art research into secure communication based on quantum cryptography. The present security model together with its assumptions, strengths and weaknesses is discussed. Recent experimental progress and remaining challenges are surveyed as are the latest developments in quantum hacking and countermeasures. Secure communication is crucial in the Internet Age, and quantum mechanics stands poised to revolutionize cryptography as we know it today. In this Review, we introduce the motivation and the current state of the art of research in quantum cryptography. In particular, we discuss the present security model together with its assumptions, strengths and weaknesses. After briefly introducing recent experimental progress and challenges, we survey the latest developments in quantum hacking and countermeasures against it.
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium (2001)

The CC chemokine receptor 8 (CCR8) is expressed on monocytes and type 2 T lymphocytes. CCR8 is the sole receptor for the human CC chemokine I-309, as well as for viral monocyte inflammatory protein-I (vMIP-I), a human chemokine homologue induced in human cells by the Kaposi sarcoma-related human herpesvirus-8. Recently it was found that I-309 messenger RNA and protein are expressed by human umbilical vein endothelial cells (HUVECs) and that the secretion of endothelial I-309 is stimulated by apolipoprotein(a). I-309, vMIP-I, and the conditioned medium from apolipoprotein(a)-stimulated HUVECs induce endothelial chemotaxis. A polyclonal anti-CCR8 antibody and a newly developed murine monoclonal antibody against CCR8 inhibited this activity. The G-protein inhibitor pertussis toxin also inhibited endothelial chemotaxis, providing further evidence for a chemokine receptor-mediated effect. Endothelial cells contain CCR8 mRNA as shown by RNA blot analysis as well by direct sequence analysis. Immunohistochemical studies identified CCR8 and I-309 on the endothelium of human atherosclerotic plaques and in endothelial-derived spindle cells of Kaposi sarcoma. These results indicate that CCR8 is an endothelial receptor that may modulate endothelial function.