gebhart/patrepeval huggingface dataset:
Salient local visual features for shape-based 3D model retrieval (2008)

In this paper, we describe a shape-based 3D model retrieval method based on multi-scale local visual features. The features are extracted from 2D range images of the model viewed from uniformly sampled locations on a view sphere. The method is appearance-based, and accepts all the models that can be rendered as a range image. For each range image, a set of 2D multi-scale local visual features is computed by using the Scale Invariant Feature Transform [22] algorithm. To reduce cost of distance computation and feature storage, a set of local features describing a 3D model is integrated into a histogram using the Bag-Of-Features approach. Our experiments using two standard benchmarks, one for articulated shapes and the other for rigid shapes, showed that the methods achieved the performance comparable or superior to some of the most powerful 3D shape retrieval methods.
Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK) (1994)

Although the number of patients was too small for a definite benefit-risk assessment, at the dosage tested, hirudin in combination with front-loaded alteplase and aspirin may be associated with an increased rate of intracranial hemorrhage. Our findings are consistent with the observations of the GUSTO-II and TIMI-9 trials, where higher doses of another recombinant hirudin were used. Therefore, the therapeutic range of hirudin as an adjunct to thrombolysis may be smaller than previously thought, and reappraisal of dose finding should be considered.
Clinical Effects of the 5-HT1A Partial Agonists in Depression (1990)

The azapirone class of anxiolytic drugs is being evaluated for clinical use in the treatment of depression. Buspirone, a serotonin (5-hydroxytryptamine, 5-HT) partial agonist active at the 5-HT1A receptor subtype, was evaluated in the treatment of depression in a series of five placebo-controlled, parallel group studies involving 382 patients with DSM-III major depression and significant associated anxiety symptoms (both Hamilton depression [HAM-D] and Hamilton anxiety [HAM-A] scales greater than or equal to 18). Buspirone therapy was initiated at 15 mg/day with individual dose titration to a maximum of 90 mg/day and resulted in marked improvement in both depressive and anxiety symptoms. Analyses of the composite data base from the five studies show significant (p less than 0.05) improvement in mean HAM-D, HAM-A, and Clinical Global Impression-Global Improvement scale ratings for buspirone-treated compared with placebo-treated patients. Of particular interest was significant improvement in cardinal depression symptoms, e.g., depressed mood, guilt, work and interest, anergia, and diurnal variation of mood. Subset analyses revealed that patients with melancholic-type major depression and patients with more severe symptoms (judged by higher initial HAM-D or HAM-A total scores) responded better to buspirone than did patients who were less ill. The buspirone dose most frequently associated with clinically significant improvement was 40 mg/day. Gepirone, an analogue of buspirone with highly selective binding affinity for the 5-HT1A receptor subtype, also shows promise of antidepressant efficacy in preliminary controlled clinical trials. These data suggest that azapirones, which as partial agonists modulate 5-HT1A receptor function, have clinically important antidepressant properties.
Polyacrylamide gel electrophoresis used in a critical study of precipitation reagents for quantifying HDL cholesterol. (1989)

Journal Article Polyacrylamide gel electrophoresis used in a critical study of precipitation reagents for quantifying HDL cholesterol. Get access D Roche, D Roche Lab. Central de Biochimie, Hôpital Laënnec, Paris, France Search for other works by this author on: Oxford Academic Google Scholar V Arneodo, V Arneodo Lab. Central de Biochimie, Hôpital Laënnec, Paris, France Search for other works by this author on: Oxford Academic Google Scholar N T Lequang, N T Lequang Lab. Central de Biochimie, Hôpital Laënnec, Paris, France Search for other works by this author on: Oxford Academic Google Scholar O G Ekindjian O G Ekindjian Lab. Central de Biochimie, Hôpital Laënnec, Paris, France Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 35, Issue 6, 1 June 1989, Pages 1254–1255, https://doi.org/10.1093/clinchem/35.6.1254 Published: 01 June 1989
Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor (1986)

Monoclonal antibodies for the human insulin receptor were produced following immunization of mice with IM-9 lymphocytes and/or purified placental receptor. Four separate fusions yielded 28 antibodies, all of which reacted with receptor from human placenta, liver and IM-9 cells. Some antibodies cross-reacted to varying degrees with receptor from rabbit, cow, pig and sheep, but none reacted with rat receptor. At least 10 distinct epitopes were recognized as indicated by species specificity and binding competition experiments. All of these epitopes appeared to be on extracellular domains of the receptor as shown by binding of antibodies to intact cells. In some cases the epitopes were further localized to alpha or beta subunits by immunoblotting. Several antibodies inhibited binding of 125I-insulin to the receptor, some had no effect on binding, and others enhanced the binding of 125I-insulin. It is concluded that these antibodies will be valuable probes of receptor structure and function.
Complete Inactivation of Target mRNA by Biotinylated Antisense Oligodeoxynucleotide-Avidin Conjugates (1994)

Biotinylation of phosphodiester oligodeoxynucleotides (PO-ODN) allows for conjugation to avidin-based transcellular delivery systems. In addition, biotinylation of PO-ODN at the 3'-terminus provides complete protection against serum 3'-exonuclease degradation. The present study was undertaken to determine if antisense 3'-biotinylated PO-ODN-avidin constructs are able to recognize and inactivate the target mRNA through RNase H-mediated degradation. A 21-mer antisense PO-ODN complementary to the tat gene encompassing nucleotides 5402-5422 of the HIV-1 genome was synthesized with biotin conjugated to the 3'-terminus (bio-tat). Gel mobility assays using [5'-32P]-labeled bio-tat ODN and avidin showed that the bio-tat ODN was fully monobiotinylated. Aliquots of [32P]-labeled sense or antisense tat RNA (337 and 351 nucleotides, respectively) were prepared from transcription plasmids and were preincubated with an excess of bio-tat ODN with or without avidin constructs and digested with RNase H. Products were resolved with sequencing gel and analyzed by autoradiography. Complete conversion to predicted RNA fragments resulting from RNase H digestion of the RNA-ODN duplex (53 and 263 nucleotides) was observed when [32P]-tat sense RNA was incubated with antisense bio-tat ODN or conjugated to avidin or an avidin-cationized human serum albumin (cHSA) complex. Conversely, no degradation of [32P]-tat-antisense RNA was observed after incubation with antisense bio-tat ODN and RNase H. In addition, the avidin-cHSA complex significantly increased (84-fold) the uptake of [32P]-internally labeled bio-tat ODN and its stability against cellular nuclease degradation in peripheral blood lymphocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins (1984)

The need for drugs that lack the obtrusive and limiting side effects of the tricyclic antidepressants has prompted the search for agents with greatly enhanced selectivity for specific mechanisms believed to be essential for antidepressant efficacy. The potential role of derangements of 5-HT pathways in the etiology of depression has long been suspected and has given impetus to the development of newer compounds that accentuate inhibition of serotonin reuptake. This paper presents structure-activity relationships for a series of cis-1-amino-4-(substituted-aryl)tetralins, which are surprisingly potent and selective inhibitors of serotonin uptake in in vitro models. These compounds are pharmacologically distinct from corresponding members of the trans series, which also potently block uptake of dopamine and norepinephrine. The activity in both cis and trans series is stereospecific, being restricted to the cis-(1S,4S) and the trans-(1R,4S) enantiomers.
Exchange of a single amino acid interconverts the specific activity and gel mobility of human and rat ciliary neurotrophic factors. (1993)

Human and rat ciliary neurotrophic factors (CNTF), which share 85% sequence identity, promote the survival of chicken embryo ciliary ganglia neurons in vitro, but display a 4-5-fold difference in specific activity. To explore the origin of this difference and gain insight into the structural organization of CNTF, we created chimeric proteins of these two species. Surprisingly, we found that the differences in two apparently unrelated properties, gel mobility and specific activity, resided in a single amino acid. Substituting arginine residue 63 of rat CNTF into the human sequence created a protein with the properties of rat CNTF. Conversely, substituting the human CNTF glutamine residue 63 into rat CNTF generated a protein with the properties of human CNTF. Binding experiments confirmed that the distinct specific activities of human and rat CNTF and their chimeras reside in structural differences among these ligands rather than species differences in their receptors. Alanine substitution (Q63A) had no effect on the properties of human CNTF, whereas the R63A substitution reduced both the gel mobility and the specific activity of rat CNTF. Finally, a Q95R substitution at a different position of human CNTF had no effect on its properties. These results demonstrate that Arg-63 is both specific and critical in determining the structural differences of human and rat CNTF.
Construction and Characterization of Retroviral Vectors Expressing Biologically Active Human Interleukin-12 (1994)

Interleukin-12 (IL-12) is a heterodimeric cytokine originally defined by its ability to induce the maturation of cytolytic lymphocytes and by its capacity to effectively synergize with IL-2 in the induction of cytolytic activity. Recent studies in mice have demonstrated the ability of IL-12 to cause tumor regression and stimulate long-term antitumor immunity in treated animals. To examine the antitumor effect of direct gene transfer of IL-12 into tumors, we have developed retroviral vectors that coordinately express both subunits of IL-12. An MFG-based retroviral vector was used to generate a recombinant retrovirus in which a long terminal repeat (LTR)-driven polycistronic transcript encodes both subunits of human IL-12: hp35 and hp40 cDNAs are linked and coexpressed using the internal ribosome entry site (IRES) from the encephalomyocarditis virus (DFG-hIL-12). In addition, two IRES sequences were used to express both subunits of IL-12 and a neomycin resistance (neoR) selectable marker gene from the same polycistronic message (TFG-hIL-12). The amphotropic DFG-hIL-12 and TFG-hIL-12 viruses were used to infect both human and murine cell lines as well as primary tumor cultures. The production of human IL-12 by the nonselected, infected cells was measured in both a PHA blast proliferation bioassay and an ELISA and ranged from 15 to 40 ng/10(6) cells per 24 hr. Following G418 selection of TFG-hIL-12-infected cells, the level of expression of IL-12 was significantly higher (up to 120 ng/10(6) cells per 24 hr). The IL-12 protein secreted by the infected cells exhibited all of the biologic activities of recombinant hIL-12: proliferation of activated natural killer (NK) and T cells, stimulation of interferon-gamma (IFN-gamma) induction by NK and T cells, and enhancement of lymphokine-activated killer (LAK) activity. These retroviral vectors expressing human IL-12 should be useful in evaluating the biological properties of IL-12 as well as for use in clinical trials for gene therapy of patients with cancer.
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties (2001)

Four novel macromolecular MRI contrast agents, all of which had the same chemical composition but different molecular weights, were prepared using generation-3, -4, -5, and -6 polyamidoamine (PAMAM) dendrimers conjugated with a bifunctional diethylenetriaminepentaacetic acid derivative to change the blood retention, tissue perfusion, and excretion. Size-dependent changes in the pharmacokinetics were observed in the biodistribution study. (153)Gd-labeled generation-6 PAMAM-conjugates remained in the blood significantly longer than all of the other preparations (P < 0.001). The increase in blood-to-organ ratio of the preparations was found to correlate with increasing molecular size (P < 0.001). Additionally, 3D-micro MR images and angiography of mice of high quality and detail were obtained using PAMAM-(1B4M-Gd)x as a macro-molecular MRI contrast agent with a 1.5-T clinical MRI instrument. Numerous fine vessels of approximately 200 microm diameter were visualized on subtracted 3D-MR angiographms with G6D-(1B4M-Gd)(192). The quality of the images was sufficient to estimate the microvasculature of cancerous tissue for anti-angiogenesis therapy and to investigate knockout mice. Magn Reson Med 45:454-460, 2001.
A CARBON DIOXIDE FLUX GENERATOR FOR TESTING INFRARED GAS ANALYZER-BASED SOIL RESPIRATION SYSTEMS (2004)

An artificial flux generation device was developed to test the accuracy of a closed-dynamic soil respiration system (LICOR 6400). The device consisted of an enclosed reservoir with a porous top; the reservoir contained a volume of CO2 enriched air, which was monitored by an infrared gas analyzer (IRGA). When the internal CO2 concentration within the reservoir was elevated, diffusion rates through the porous medium were measured by recording changes in CO2 concentration within the reservoir. This diffusion-based artificial flux mimics natural soil respiration, and allows an independent verification of the accuracy of soil respiration measurement systems. We tested a LI-COR 6400 portable photosynthesis system fitted with a 6400-09 soil CO2 flux chamber. On average, this system overestimated high flux rates by 2 to 4% and underestimated low flux rates by 4 to 20% over five independent trials. Soil respiration appeared to be sensitive to boundary layer mixing, and ambient CO2 concentrations.
Circular Polarized Ground Radiation Antenna for Mobile Applications (2018)

Here, we propose a ground radiation antenna (GradiAnt) with circular polarization (CP) by applying the ground-mode tuning (GMT) technique to the ground plane. We demonstrate that a GradiAnt at an arbitrary location of the ground plane can simultaneously excite two orthogonal modes of the same magnitude, and the phase difference between the two modes can be adjusted via GMT to achieve CP in mobile antennas. The proposed GradiAnt can be viewed as a combination of an electric coupler (J-type) and magnetic coupler (M-type) to the modes of the ground plane, and both modes can be excited to the same amplitude by tuning the coupling-type. GMT, applied to the ground modes using inductor-connected metal strips, can generate a 90° phase difference between the two modes of the ground plane. The proposed antenna design generates a 6 dB axial ratio bandwidth of 140 MHz from 2.38 to 2.52 GHz in the +z-direction. Right-hand CP and left-hand CP in the +z-direction and -z-direction, respectively, are obtained. The tuning mechanism is presented, and measurements are taken to validate the proposed technique.
Recombinant Listeria monocytogenes cancer vaccines (1996)

Listeria monocytogenes has recently been exploited as a vector for targeting antigens to the immune system. In the past year it has been shown to be particularly effective as a tumor antigen vector. Here we set its potency as a cancer vaccine in the context of the type of immunity induced by this facultative intracellular bacterium.
Color and Constitution. V.1 The Absorption of Unsymmetrical Cyanines. Resonance as a Basis for a Classification of Dyes (1942)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColor and Constitution. V.1 The Absorption of Unsymmetrical Cyanines. Resonance as a Basis for a Classification of DyesL. G. S. Brooker, G. H. Keyes, and W. W. WilliamsCite this: J. Am. Chem. Soc. 1942, 64, 2, 199–210Publication Date (Print):February 1, 1942Publication History Published online1 May 2002Published inissue 1 February 1942https://pubs.acs.org/doi/10.1021/ja01254a002https://doi.org/10.1021/ja01254a002research-articleACS PublicationsRequest reuse permissionsArticle Views1221Altmetric-Citations111LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Towards a non-contact driver-vehicle interface (2002)

A novel, non-contact, pointing interface is being developed for the control of non-safety critical systems inside a vehicle with the aims of improving safety, decreasing manufacturing cost and improving the ease of driver migration between different cars. A driver operates the interface via an on-screen cursor using pointing gestures to be identified by a computer vision system. This paper describes the vision subsystem responsible for detection and tracking of the driver's hands. To be robust, it must detect and track under varying lighting conditions with no prior assumptions concerning the colour of the hands or clothing. Adaptive foreground and background models are used for segmentation and a robust geometrical hand model is employed for tracking. The system is demonstrated working at speeds close to real-time on a standard PC using image sequences captured inside a car.
Molecular-Genetic Characterization of CMS-SRestorer-of-FertilityAlleles Identified in Mexican Maize and Teosinte (2004)

Abstract Restorer-of-fertility (Rf) alleles for S-type cytoplasmic male sterility (CMS-S) are prevalent in Mexican races of maize and teosinte. Forty-five Rf alleles from 26 races of maize and 6 Rf alleles from different accessions of teosinte were found to be homozygous viable, consistent with the hypothesis that they are naturally occurring Rf alleles. Mapping and allelism studies were performed to assess the number of genes represented by these 51 alleles. Forty-two of the Rf alleles mapped to the long arm of chromosome 2 (2L), and 5 of these were further mapped to the whp1-rf3 region. The Rf3 restoring allele, found in some U.S. maize inbred lines, cosegregates with internal processing of CMS-S mitochondrial transcripts. Three of the 5 mapped Rf alleles were associated with a similar RNA processing event. Allelism or tight linkage was confirmed between Rf3 and 2 teosinte alleles (Rf K-69-6 and Rf 9477) and between Rf3 and the Cónico Norteño allele Rf C-N (GTO 22). The rf3 region of 2L potentially encodes a complex of linked rf genes. The prevalence of restoring alleles in this chromosomal region, among normal-cytoplasm accessions of Mexican maize and teosinte, supports the conclusion that these alleles have functions in normal mitochondrial gene expression that by chance allow them to restore male fertility in S cytoplasm.
Role of CD28 in the Generation of Effector and Memory Responses Required for Resistance to Toxoplasma gondii (1999)

CD28 deficient (CD28-/-) mice were used to study the role of costimulation in the T cell-mediated, IFN-gamma-dependent mechanism of resistance to Toxoplasma gondii. These mice were resistant to infection with the ME49 strain of T. gondii. Analysis of the immune response of acutely infected CD28-/- mice revealed that IL-12 was required for T cell production of IFN-gamma and this was independent of the CD40/CD40 ligand interaction. A similar mechanism of IL-12-dependent, CD28/B7 independent production of IFN-gamma by T cells was also observed in wild-type mice. Interestingly, although chronically infected wild-type mice were resistant to rechallenge with the virulent RH strain of T. gondii, chronically infected CD28-/- mice were susceptible to rechallenge with the RH strain. This deficiency in the protective memory response by CD28-/- mice correlated with a lack of IL-2 and IFN-gamma in recall responses and reduced numbers of CD4+ T cells expressing a memory phenotype. Together, our findings demonstrate that CD28 is not required for the development of a protective T cell response to T. gondii, but CD28 is required for an optimal secondary immune response.
THE ISOMERIC OCTACETATES OF LACTOSE. (1915)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE ISOMERIC OCTACETATES OF LACTOSE.C. S. Hudson and J. M. JohnsonCite this: J. Am. Chem. Soc. 1915, 37, 5, 1270–1275Publication Date (Print):May 1, 1915Publication History Published online1 May 2002Published inissue 1 May 1915https://pubs.acs.org/doi/10.1021/ja02170a026https://doi.org/10.1021/ja02170a026research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts