gebhart/patrepeval huggingface dataset:
Perception of age in adult Caucasian male faces: computer graphic manipulation of shape and colour information (1995)

This study investigated visual cues to age by using facial composites which blend shape and colour information from multiple faces. Baseline measurements showed that perceived age of adult male faces is on average an accurate index of their chronological age over the age range 20-60 years. Composite images were made from multiple images of different faces by averaging face shape and then blending red, green and blue intensity (RGB colour) across comparable pixels. The perceived age of these composite or blended images depended on the age bracket of the component faces. Blended faces were, however, rated younger than their component faces, a trend that became more marked with increased component age. The techniques used provide an empirical definition of facial changes with age that are biologically consistent across a sample population. The perceived age of a blend of old faces was increased by exaggerating the RGB colour differences of each pixel relative to a blend of young faces. This effect on perceived age was not attributable to enhanced contrast or colour saturation. Age-related visual cues defined from the differences between blends of young and old faces were applied to individual faces. These transformations increased perceived age.
X-Ray crystal structure of C6H3(CO2H)3-1,3,5·1.5(4,4′-bipy): a ‘super trimesic acid’ chicken-wire grid (1996)

Trimesic acid cocrystallizes with 1.5 equivalents of 4,4′-bipyridine to generate a large distorted hexagonal network with ca. 35 × 26 Å internal dimensions: three independent networks interweave to afford a novel threefold two-dimensional corrugated sheet.
Glucosamine modulates IL‐1‐induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF‐κB pathway (2001)

We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in UDP-glucuronosyltransferase I mRNA expression induced by interleukin-1 beta (IL-1 beta) [Arthritis Rheum. 44 (2001) 351-360]. In the present work, we show that glucosamine does not exert the same effects when chondrocytes were stimulated with reactive oxygen species (ROS). In order to better understand its mechanism of action, we determined if glucosamine could prevent the binding of IL-1 beta to its cellular receptors or could interfere with its signaling pathway at a post-receptor level. Addition of glucosamine to rat chondrocytes treated with IL-1 beta or with ROS decreased the activation of the nuclear factor kappa B, but not the activator protein-1. After treatment with IL-1 beta, glucosamine increased the expression of mRNA encoding the type II IL-1 beta receptor. These results emphasize the potential role of two regulating proteins of the IL-1 beta signaling pathway that could account for the beneficial effect of glucosamine in osteoarthritis.
Megakaryocyte biology and related disorders (2005)

Platelets, derived from megakaryocytes, have an essential role in thrombosis and hemostasis. Over the past 10 years, a great deal of new information has been obtained concerning the various aspects of hematopoiesis necessary to maintain a steady-state platelet level to support physiologic hemostasis. Here we discuss the differentiation of HSCs into megakaryocytes, with emphasis on the key cytokine signaling pathways and hematopoietic transcription factors. Recent insight into these processes elucidates the molecular bases of numerous acquired and inherited hematologic disorders. It is anticipated that the growing knowledge in these areas may be exploited for new therapeutic strategies to modulate both platelet numbers and their thrombogenicity.
Shock-induced analgesia on the formalin test: Effects of shock severity, naloxone, hypophysectomy, and associative variables. (1984)

Rats were exposed to three shocks, spaced 20 s apart, at two different levels of severity, low (.75 s, 1 mA) and high (3 s, 4 mA). Both shock levels produced a similar suppression of the recuperative behavior elicited by an injection of formalin into a rat's hind paw. Naloxone fully reversed the analgesia produced by the low-severity shock but only partially reversed the analgesia produced by the high-severity shock (Experiment 1). Hypophysectomy did not alter the level of analgesia (Experiment 2). When the rats were tested in a chamber different from the one they were shocked in, both analgesias were totally reversed (Experiment 3). However, imposing a delay between shock and analgesia testing did not reduce analgesia (Experiment 4). These results suggest that analgesia is not directly elicited by the shock but by apparatus stimuli associated with shock. Further support for this position was obtained when it was found that a Pavlovian extinction procedure could completely eliminate analgesia (Experiment 5). In all of the experiments, the freezing response, one of the rat's species-specific defense reactions, was monitored simultaneously with recuperative behavior. A parallel was found between analgesia and this defensive response, a result suggesting that an animal's endogenous analgesic systems may be activated along with the animal's defensive motivational system. The results point to the critical nature of associative variables in the control of endogenous analgesic systems. They also suggest that shock severity is a determinant of analgesia's sensitivity to naloxone.
Necrosis and apoptosis in acute renal failure. (1998)

Renal tubular cells that are lethally injured after an acute ischemic or nephrotoxic insult to the kidney can die by necrosis or apoptosis. Necrosis is usually the result of overwhelming and severe cellular ATP depletion. In contrast, there are many potential causes of apoptosis in acute renal failure (ARF). These include cytotoxic events not severe enough to induce necrosis, a relative deficiency of renal growth factors, and loss of cell-matrix or cell-cell adhesive interactions. In some situations, receptor-mediated events induced by tumor necrosis factor-alpha (TNF-alpha) or Fas (CD95) may play a role in apoptosis in ARF. Necrosis and apoptosis are distinct morphologically and biochemically. Necrosis results in an early loss of plasma membrane integrity, the release of injurious substances from the cytosol, and an inflammatory reaction in the surrounding tissue that is readily detected morphologically. In contrast, apoptosis is characterized by progressive cell shrinkage with condensation and fragmentation of nuclear chromatin. Apoptotic cells ultimately break up into plasma membrane-bound vesicles called "apoptotic bodies" that are rapidly phagocytosed by macrophages and neighboring epithelial cells. In experimental models of ARF in vivo, apoptosis of renal tubular cells has been shown to occur in two distinct phases. The first phase of apoptosis occurs early on, between 12 and 48 hours after the acute ischemic or nephrotoxic insult. The second phase of apoptosis occurs many days later, during the recovery phase of ARF. Tubular cell apoptosis occurring shortly after the acute insult probably contributes to tubular cell loss and the tubular dysfunction associated with ARF. In contrast, the apoptosis associated with the recovery phase has been postulated to contribute to the remodeling of injured tubules and to facilitate their return to a normal structural and functional state. Therapeutic interventions that inhibit or promote apoptosis of renal tubular cells have the potential for minimizing renal dysfunction and accelerating recovery after ARF.
Fast, Accurate and Inelegant Valuation of American Options (1997)

In this short article, we describe the pricing of an American option (call or put) on a share which may pay continuous dividends, using a method described by Broadie & Detemple (1997) as 'not very elegant'. The method is simply to build a look-up table of option prices, which thus splits the problem of pricing American option prices into three sub-problems:
Mass‐dependent decline of skeletal muscle function in cancer cachexia (2005)

CD2F1 mice were inoculated with C26 adenocarcinoma cells, followed by assessment of ex vivo muscular function. Muscles from tumor-bearing mice had a significantly lower force output during a single maximal contraction and during repeated contractions than control muscles. The relative force output, however, did not differ when corrected for muscle mass. Thus, cachexia significantly reduces absolute skeletal muscle function, but muscle "quality" appears unaltered.
Design and Synthesis of a 3,4-Dehydroproline Amide Discovery Library (2007)

The synthesis of a discovery library of 80 3,4-dehydroproline amides was achieved in a four-step reaction sequence from easily accessible 3-aminoallene-3-carboxylate methyl esters. Diversification of these proline mimics was introduced at five different sites: the substituents at the 3-pyrroline unit (R1, R2, R3), at the nitrogen (R4), and the C-terminus (R5). The 3-pyrroline scaffold was synthesized in excellent yields by a silver-catalyzed intramolecular cyclization of aminoallenes, followed by N-functionalization reactions. Maximum diversity was introduced in the final step of the reaction sequence by taking advantage of the carboxylic acid handle of the 3-pyrroline subunit. Amide coupling reactions using polystyrene-carbodiimide (PS-carbodiimide) and 1-hydroxybenzotriazole (HOBt) under microwave irradiation led to 3,4-dehydroproline amides that were obtained in purities greater than 85% by LC/MS/ESLD after scavenging the excess HOBt on a silica-bound carbonate SPE cartridge.
A SYNTHETIC SINGLE‐STRANDED DNA, POLY(dG, dC), INDUCES TNTERFERON‐α/β AND ‐γ, AUGMENTS NATURAL KILLER ACTIVITY, AND SUPPRESSES TUMOR GROWTH (1988)

When various synthetic double- or single-stranded DNAs were incubated with spleen cells from mice (BALB/c or CDF1) at 37 degrees for 20 hr, it was found that some of the DNAs augmented NK activity and produced factors in the culture supernatants which showed antiviral activity and activity to render mouse macrophages cytotoxic toward tumor cells. Poly(dG,dC) showed the strongest activities, when incubated with spleen cells from lipopolysaccharide-nonresponsive mice, C3H/HeJ. The activity of the culture supernatant to activate macrophages was completely abolished by a small amount of anti-IFN gamma antibody. On the other hand, the virus-inhibitory activity of the supernatant was mostly neutralized by anti-IFN alpha/beta. When IMC tumor cells (5 x 10(5) cells) were mixed with poly(dG,dC) (100 micrograms) and then inoculated intradermally into CDF1 mice, the tumor did not take, while tumors grew progressively and killed the mice in a control group inoculated with tumor cells alone. Direct cytotoxicity of poly(dG,dC) at a concentration of 1,000 micrograms/ml against IMC cells was not observed in vitro.
Poisson matting (2004)

In this paper, we formulate the problem of natural image matting as one of solving Poisson equations with the matte gradient field. Our approach, which we call Poisson matting , has the following advantages. First, the matte is directly reconstructed from a continuous matte gradient field by solving Poisson equations using boundary information from a user-supplied trimap. Second, by interactively manipulating the matte gradient field using a number of filtering tools, the user can further improve Poisson matting results locally until he or she is satisfied. The modified local result is seamlessly integrated into the final result. Experiments on many complex natural images demonstrate that Poisson matting can generate good matting results that are not possible using existing matting techniques.
Ongoing Dll4‐Notch signaling is required for T‐cell homeostasis in the adult thymus (2011)

The essential role of the Delta-like ligand 4 (Dll4)-Notch signaling pathway in T-lymphocyte development is well established. It has been shown that specific inactivation of Dll4 on thymic stromal cells during early post-natal development leads to a deregulation in T-cell differentiation. However, whether ongoing Dll4-Notch signaling is required for T-cell development in the adult thymus is unknown. The use of anti-Dll4 Abs allowed us to confirm and expand previous studies by examining the kinetics and the reversibility of Dll4-Notch signaling blockade in T-cell development in adult mice. We found that anti-Dll4 treatment reduced thymic cellularity after 7 days, as a consequence of a developmental delay in T-cell maturation at the pro-T-cell double negative 1 (CD4(-) CD8(-) c-kit(+) CD44(+) CD25(-) ) stage, leading to decreased numbers of immature double-positive (CD4(+) CD8(+) ) T cells without affecting the frequency of mature single positive CD4(+) and CD8(+) thymocytes, while promoting alternative thymic B-cell expansion. This cellular phenotype was similarly observed in both young adult and aged mice (>1.5 years), extending our understanding of the ongoing role for Dll4-Notch signaling during T-cell development in the adult thymus. Finally, after cessation of Dll4 Ab treatment, thymic cellularity and thymocyte subset ratios returned to normal levels, indicating reversibility of this phenotype in both adult and aged mice, which has important implications for potential clinical use of Dll4-Notch inhibitors.
Comparison of LH-RH Analogue 1-Month Depot and 3-Month Depot by Their Hormone Levels and Pharmacokinetic Profile in Patients with Advanced Prostate Cancer (1998)

In an open, randomized phase II pharmacokinetic study conducted in Germany and Italy, a total of 42 patients with advanced or metastatic prostate cancer (PCa) were treated for 9 months with the luteinizing hormone-releasing hormone analogue (LH-RH-a) leuprorelin acetate depot in two different formulations. Fifteen patients received the 1-month depot and 27 patients received the newly developed 3-month depot, containing 3.75 mg and 11.25 mg, respectively. In both groups, subcutaneous injections of leuprorelin acetate injected monthly or at 3-month intervals produced a complete down-regulation of the pituitary and led to persistent suppression of testosterone and dihydrotestosterone to the castrate range (< or = 50 ng/dl for testosterone) within the first month of treatment, which thereafter could be maintained over the entire observation period of 9 months. In 10 patients, pretreatment with an antiandrogen for the prevention of clinical flare-up resulted in a slightly more profound and earlier drop in serum testosterone. The 3-month depot showed a higher median peak serum concentration (Cmax) of leuprorelin at 20.8 ng/ml than the 1-month depot at 10.7 ng/ml but, conversely, this did not influence the rise in serum testosterone levels. Cmax occurred at 3 h for the 3-month and at 1 h for the 1-month depot formulation. During the steady state, constant release could be detected, starting on day 3 and day 7 for the 1-month and 3-month depot, respectively. A marked decrease in median prostate-specific antigen levels of 97.8% (1-month depot) and 96.6% (3-month depot) compared with baseline was observed, indicating an objective clinical response for more than 80% of all patients in both arms. Based on European Organization for Research and Treatment of Cancer criteria, the best response in terms of complete/partial remissions and stabilization was comparable in the two arms at 86.7% (1-month depot) and 85.2% (3-month depot). 6.7% in the 1-month group and 3% in the 3-month depot group showed progression of the disease. The most common side effects in both treatment groups were related to hormone deprivation. Both formulations of the potent LH-RH-a leuprorelin acetate were highly effective in the treatment of advanced PCa and led to comparable endocrine and clinical effects.
Agrobacterium tumefaciens soxR Is Involved in Superoxide Stress Protection and Also Directly Regulates Superoxide-Inducible Expression of Itself and a Target Gene (2006)

Inactivation of Agrobacterium tumefaciens soxR increases sensitivity to superoxide generators. soxR expression is highly induced by superoxide stress and is autoregulated. SoxR also directly regulates the superoxide-inducible expression of atu5152. Taken together, the physiological role of soxR and the mechanism by which it regulates expression of target genes make the A. tumefaciens SoxR system different from other bacterial systems.
Synthesis and some biological properties of analogue of angiotensin with modified proline structure (1990)

The [1-asparagine]angiotensin analogue was synthesized by fragment condensation employing the azide method. Proline in the position 7 in this analogue and phenylalanine in the position 8 were substituted with 2-[1-(2-oxo-3-aminopyrrolidinyl)]-3-phenylpropanoic acid. The analogue does not exhibit any agonistic nor antagonistic activity in myotropic, histamin releasing and pressoric tests.
[Unification of methods for determining the trace quantities of lead, zinc, sodium and potassium ions in the assessment of drinking water adn transfusion fluid quality]. (2001)

The results of long-term studies made by the Department of General Chemistry, I. M. Sechenov Moscow Medical Academy, that deals with unification of methods for determining some ions of metals (lead, zinc, sodium, and potassium) in the assessment of the quality of drinking water and transfusion fluids are summarized. A procedure was developed to determine the trace impurities of zinc, lead, and silver by atomic absorption spectrometry (AAS) by using sorption concentration. C-80-2-aminothiazole, a new sorbent synthesized at the Research Institute of Polymers, was used to detect these ions in the drinking water. With regards to the chosen optimal conditions, drinking water samples were analyzed via their direct spraying in the air-acetylene flame. The prior sorption concentration determined drinking water zinc and lead ions in the concentrations equal to or less than their permissible dose concentrations. The studies indicated that the used methods to determine the trace quantities of metals in the drinking water and aqueous solutions show a high sensitivity, rapidity, simplicity of sample preparation.
Regulation of smooth muscle cell proliferation and its possible role in preventing restenosis post-angioplasty. (1995)

The introduction of balloon angioplasty in 1978 as an alternative treatment for vascular stenosis has created a new clinical problem: restenosis, the renarrowing that occurs after the procedure in certain patients. Restenosis is an important long-term complication, with an incidence of 30-50% within 6 months post-angioplasty. Three mechanisms contribute to vascular restenosis: recoil, thrombus formation and direct trauma. Growth factors which enhance the expression of other growth-regulating proteins, in particular "second messengers", proto-oncogenes and other cell cycle controlling proteins, are released by local thrombi and the injured arterial segment itself, resulting in an excessive inflammatory and myofibroproliferative response which culminates in restenosis. From investigations in animal models it is known that restenosis takes place in several phases: thrombosis, inflammation, cell proliferation and matrix formation. Various factors seem to interact in each particular phase, either as agonists or antagonists; hence the pathway that results in restenosis is complex. The introduction of directional percutaneous atherectomy has made it possible to examine human arterial tissue obtained in vivo, including restenosis material, from a sufficient number of patients in order to complement animal experiments. Not all of the mechanisms which lead to restenosis are known; nevertheless, after more than 15 years' experience of balloon angioplasty, there is an urgent need to develop therapeutic strategies based on currently available information. Selective elimination or alteration of proliferating cells, enhancement of natural growth inhibitors, blocking of signal transduction or inhibition of the gene expression for distinct growth-stimulating proteins all appear to be potentially promising.
Guidelines for clinical guidelines (1998)

Clinical guidelines are systematically developed statements designed to help practitioners and patients make decisions about appropriate health care for specific circumstances.1 Clinicians are being inundated by a tidal wave of guidelines. In Britain alone, regional programmes for audit have recently developed about 2000 guidelines or protocols.2 In addition to numerous clinical guidelines, a number of “guidelines for guidelines” have been produced, ranging from simple3 to complex.4 These reflect the increasing attention being paid to the methodology of guidelines development and the validity of guideline recommendations. While we support the increasingly rigorous approach taken to guideline development, it is important to re-emphasise the central role of guidelines themselves, which is to help clinicians make better decisions.

Clinicians need simple, patient specific, user friendly guidelines. We highlight three key components for such guidelines. The first is the explicit identification of the major decisions, relevant to patients, which have to be made, and the possible consequences of these decisions. Many encounters with patients involve multiple decisions, so the key to developing usable guidelines is to identify …
Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. (1996)

Gene transduction of pluripotent human hematopoietic stem cells (HSCs) is necessary for successful gene therapy of genetic disorders involving hematolymphoid cells. Evidence for transduction of pluripotent HSCs can be deduced from the demonstration of a retroviral vector integrated into the same cellular chromosomal DNA site in myeloid and lymphoid cells descended from a common HSC precursor. CD34+ progenitors from human bone marrow and mobilized peripheral blood were transduced by retroviral vectors and used for long-term engraftment in immune-deficient (beige/nude/XIS) mice. Human lymphoid and myeloid populations were recovered from the marrow of the mice after 7-11 months, and individual human granulocyte-macrophage and T-cell clones were isolated and expanded ex vivo. Inverse PCR from the retroviral long terminal repeat into the flanking genomic DNA was performed on each sorted cell population. The recovered cellular DNA segments that flanked proviral integrants were sequenced to confirm identity. Three mice were found (of 24 informative mice) to contain human lymphoid and myeloid populations with identical proviral integration sites, confirming that pluripotent human HSCs had been transduced.
Private information retrieval (1998)

Publicly accessible databases are an indispensable resource for retrieving up-to-date information. But they also pose a significant risk to the privacy of the user, since a curious database operator can follow the user's queries and infer what the user is after. Indeed, in cases where the users' intentions are to be kept secret, users are often cautious about accessing the database. It can be shown that when accessing a single database, to completely guarantee the privacy of the user, the whole database should be down-loaded; namely n bits should be communicated (where n is the number of bits in the database). In this work, we investigate whether by replicating the database, more efficient solutions to the private retrieval problem can be obtained. We describe schemes that enable a user to access k replicated copies of a database ( k ≥2) and privately retrieve information stored in the database. This means that each individual server (holding a replicated copy of the database) gets no information on the identity of the item retrieved by the user. Our schemes use the replication to gain substantial saving. In particular, we present a two-server scheme with communication complexity O(n 1/3 ).