gebhart/patrepeval huggingface dataset:
Synergistic lethal effect of cis-dichlorodiammineplatinum and 1-beta-D-arabinofuranosylcytosine. (1981)

cis-Dichlorodiammineplatinum(II) and 1-beta-D-arabinofuranosylcytosine display a dramatic synergistic effect when tested in simultaneous combination on LoVo cells, a human colon carcinoma cell line. 1-beta-D-Arabinofuranosylcytosine alone does not induce any cytotoxicity on LoVo cells even at high concentrations but is able to increase up to 1000 times the lethal effects of cis-dichlorodiammineplatinum(II). DNA elution experiments show that 1-beta-D-arabinofuranosylcytosine increases the amount of cis-dichlorodiammineplatinum(II)-induced DNA cross-links. The possible mechanisms of this effect are discussed, and some explanations are proposed.
Virology division news: Revision of taxonomic criteria for species demarcation in the family Geminiviridae, and an updated list of begomovirus species (2003)

CdTV-[H8] Cotton leaf crumple virus
Evaluation of multiple vascular reconstructive procedures with synthetic graft occlusions. (1994)

The objective of this study was to evaluate the efficiency of multiple vascular reconstructive procedures in the presence of an occluded synthetic graft. Over a four year period seventy-seven occluded synthetic grafts were treated with urokinase and reconstruction. Follow-up ranged from 1 to 1627 days (4 years, 5 1/2 months). Kaplan-Meier and generalized Wilcoxon test were used to determine patency and limb salvage rates. The cases were divided into three groups according to the number of previous reconstructive events. Group I consisted of patients that had undergone one previous vascular reconstructive procedure. Group II consisted of patients that had undergone two previous vascular reconstructive procedures. Group III consisted of patients who had undergone three or more previous reconstructive procedures. In Group I, the one, two, and three year patency rates were 48.6%, 34.7%, and 26.0% and the limb salvage rates were 76.2%, 67.9%, and 67.9% for one, two, and three years respectively. The Group II patency rates were 41.9%, 24.4%, and 16.3% and the limb salvage rates were 73.7%, 66.3%, and 66.3%. The Group III patency rates were 31.8%, 5.5%, and 5.5% and the limb salvage rates were 76.6%, 54.8%, and 54.8%. The patency rate was significantly reduced when Group III was compared to Group I (p < 0.01). There was no statistically significant difference in limb salvage rates between any of the groups. These results indicate that the number of secondary vascular reconstructive procedures combined with thrombolysis had no correlation with the prognosis of limb salvage.(ABSTRACT TRUNCATED AT 250 WORDS)
Photochemistry of tris(2,2'-bipyridine)ruthenium(2+) ion (Ru(bpy)32+). Solvent effects (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of tris(2,2'-bipyridine)ruthenium(2+) ion (Ru(bpy)32+). Solvent effectsJonathan V. Caspar and Thomas J. MeyerCite this: J. Am. Chem. Soc. 1983, 105, 17, 5583–5590Publication Date (Print):August 1, 1983Publication History Published online1 May 2002Published inissue 1 August 1983https://pubs.acs.org/doi/10.1021/ja00355a009https://doi.org/10.1021/ja00355a009research-articleACS PublicationsRequest reuse permissionsArticle Views7435Altmetric-Citations813LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins‐1 and −3 and angiotensin II in a rat sponge model (1996)

1 The angiogenic activity of four vasoactive peptides with a range of vasodilator and vasoconstrictor properties, i.e. vasoactive intestinal peptide (VIP), endothelin-1, endothelin-3 and angiotensin II, were investigated in a rat sponge model. Neovascularization was assessed by the 133Xe clearance technique and confirmed by histological studies. 2 Daily doses of the vasodilator peptide, VIP (1000 pmol), caused intense neovascularization, but a lower dose (10 pmol) produced no apparent effect. However, the lower dose of VIP, when given with a subthreshold dose of interleukin-1 alpha (0.3 pmol), produced an angiogenic response similar to that seen with the higher dose of VIP. The neovascular response induced by co-administration of VIP and interleukin-1 alpha was inhibited by simultaneous administration of 100 pmol VIP (10-28), a specific VIP receptor antagonist. 3 In contrast, daily doses of 10, 100 or 1000 pmol endothelin-3 (a mixed vasoconstrictor and vasodilator with more marked vasodilator activity) or of 100 or 1000 pmol endothelin-1 (also with mixed activity but with much more pronounced vasoconstrictor response) produced no apparent effect on sponge-induced angiogenesis. 4 The vasoconstrictor peptide, angiotensin II, in daily doses of 1000 pmol, caused an intense neovascularization like VIP but lower doses of angiotensin II (10 or 100 pmol) produced no apparent effect. The lowest dose of angiotensin II (10 pmol) when administered with the subthreshold dose of interleukin-1 alpha (0.3 pmol) had no effect on the basal neovascular response in the sponges. The angiotensin II-induced neovascular response was inhibited by co-administration of 100 nmol of the specific AT1 receptor antagonist, losartan, but not by the AT2 receptor antagonist, PD 123319. 5 These data show that VIP and angiotensin II possess angiogenic activity. However, endothelin-1 and endothelin-3 had no activity at the doses used. Thus the angiogenic response is not related to local vasoconstriction or vasodilatation in the sponges. The blockade of VIP- and angiotensin II-induced angiogenesis at the receptor level suggests that receptor modulation could provide a strategy for the management of angiogenic diseases.
Structure of low dielectric constant to extreme low dielectric constant SiCOH films: Fourier transform infrared spectroscopy characterization (2003)

Carbon doped oxide dielectrics comprised of Si, C, O, and H (SiCOH) have been prepared by plasma enhanced chemical vapor deposition (PECVD) from mixtures of tetramethylcyclotetrasiloxane (TMCTS) and an organic precursor. The films have been analyzed by determining their elemental composition and by Fourier transform infrared spectroscopy with deconvolution of the absorption peaks. The analysis has shown that PECVD of TMCTS produces a highly crosslinked networked SiCOH film. Dissociation of TMCTS appears to dominate the deposition chemistry as evidenced by the multitude of bonding environments and formation of linear chains and branches. Extensive crosslinking of TMCTS rings occurs through Si–Si, Si–CH2–Si, Si–O–Si, and Si–CH2–O–Si moieties. The films deposited from mixtures of TMCTS and organic precursor incorporate hydrocarbon fragments into the films. This incorporation occurs most probably through the reaction of the organic precursor and the Si–H bonds of TMCTS. Annealing the SiCOH films deposited from TMCTS and organic precursor results in a large loss of carbon and hydrogen from the films resulting from the fragmentation and loss of the incorporated organic component. The deconvolution of the Si–O–Si asymmetric stretching band of the annealed films shows the existence of a larger fraction of a cage structure and a correspondingly smaller fraction of a networked (highly crosslinked) structure in the SiCOH films deposited from mixtures of TMCTS with organic precursor relative to the films deposited from TMCTS only. The evolution of the volatile hydrocarbon fragments during annealing results in the formation of nanopores and subsequent reduction of the dielectric constants of the films to extreme low-k values.
Switching from differentiation to growth in hepatocytes: Control by extracellular matrix (1992)

Studies were carried out to analyze how different extracellular matrix (ECM) molecules regulate hepatocyte growth and differentiation. Freshly isolated rat hepatocytes were cultured on non-adhesive plastic dishes that were pre-coated with defined densities of either laminin, fibronectin, type I collagen, or type IV collagen. Sparse cell plating densities were used to minimize cell-cell contact formation and all studies were carried out in chemically defined medium that contained a saturating amount of soluble growth factors. Dishes coated with a low ECM density (1 ng/cm2) supported hepatocyte attachment, but did not promote cell spreading or growth. Computerized image analysis confirmed that over 80% of cells remained free of contact with other cells under these conditions. Yet, these round cells maintained high levels of albumin gene expression as well as elevated secretion rates for multiple liver-specific proteins (albumin, transferrin, and fibrinogen), regardless of the type of ECM molecule used for cell attachment. When ECM coating densities were raised from 1 to 1,000 ng/cm2, cell spreading, expression of histone mRNA, DNA synthesis, and cell proliferation all increased in parallel. Activation of growth by high ECM densities was also accompanied by a concomitant down-regulation of differentiated functions and again, dishes coated with all four types of ECM molecules produced similar effects. Thus, the ability to switch hepatocytes from differentiation to growth (i.e., between different genetic programs) is not limited to a single ECM molecule, a distinct three dimensional ECM geometry, or due to alteration of cell-cell interactions. Rather, the regulatory signals conveyed by immobilized ECM molecules depend on the density at which they are presented and thus, on their ability to either prohibit or support cell spreading.
Synovial tissue–infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation (2010)

NK cells are a principal tissue-infiltrating lymphocyte subset in patients with OA and patients with periprosthetic inflammation and display a quiescent phenotype that is consistent with postactivation exhaustion.
3.06 μm InGaAsSb/InPSb diode lasers grown by organometallic vapor-phase epitaxy (1991)

We have observed laser action at λ=3.06 μm in In0.77Ga0.23As0.74Sb0.26/InP0.7Sb0.3 double heterojunction, diode lasers, which were grown by organometallic vapor-phase epitaxy. The maximum operating temperature was T=35 K, and typical threshold current densities were 200–330 A/cm2. At temperatures up to 35 K, the lasing wavelength decreased with increasing temperature owing to a band-filling effect.
Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells. (1990)

Poly(ADP-ribose) polymerase specifically recognizes DNA strand breaks by its DNA-binding domain. DNA binding activates the enzyme to catalyze the formation of poly(ADP-ribose) utilizing NAD as substrate. By a molecular genetic approach we set out to inhibit this enzyme activity in a highly specific manner, thus avoiding the inherent side effects of NAD analogs which have been used extensively as enzyme inhibitors. cDNA sequences coding for the human poly(ADP-ribose) polymerase DNA-binding domain were subcloned into eucaryotic expression plasmids and transiently transfected into monkey cells. Cells were fixed with ethanol followed by incubation with NAD. Indirect double immunofluorescence to detect both overexpressed protein and poly(ADP-ribose) in situ revealed that overexpression of the DNA-binding domain greatly inhibited poly(ADP-ribosyl)ation catalyzed by the resident enzyme during NAD postincubation. The same inhibition was observed when transfected cells were treated with N-methyl-N'-nitro-N-nitrosoguanidine to induce DNA strand breaks in vivo and subjected to trichloroacetic acid/ethanol fixation and subsequent immunofluorescence analysis, a novel method we developed for the in situ detection of polymer synthesis in intact cells. This molecular genetic approach may prove to be a selective and efficient tool to investigate possible functions of poly(ADP-ribosyl)ation in living cells.
Ad hoc teamwork for leading a flock (2013)

Designing agents that can cooperate with other agents as a team, without prior coordination or explicit communication, is becoming more desirable as autonomous agents become more prevalent. In this paper we examine an aspect of the problem of leading teammates in an ad hoc team-work setting, where the designed ad hoc agents lead the other teammates to a desired behavior that maximizes team utility. Specifically, we consider the problem of leading a flock of agents to a desired orientation using a subset of ad hoc agents. We examine the problem theoretically, and set bounds on the extent of influence the ad hoc agents can have on the team when the agents are stationary. We use these results to examine the complicated problem of orienting a stationary team to a desired orientation using a set of non-stationary ad hoc agents. We then provide an empirical evaluation of the suggested solution using our custom-designed simulator FlockSim.
Hiv-1 Control after Transient Antiretroviral Treatment Initiated in Primary Infection: Role of Patient Characteristics and Effect of Therapy (2012)

Background The occurrence of viral control after interruption of an antiretroviral treatment (ART) initiated during primary HIV-1 infection (PHI) is rare and the frequency and predictive factors of such a control are unknown. Methods Within the French ANRS PRIMO Cohort, 164 patients interrupted ART initiated during PHI. We compared patients whose viral load (VL) remained undetectable (&lt;50 copies/ml) or low (50–500 copies/ml) 1 year after ART interruption to those who evidenced a rapid viral rebound. Results After ART interruption, VL remained undetectable for a median time of 4.5 years in 14 patients (‘post-ART controllers') and low in another 14 patients for a median time of 1.5 years. Post-ART controllers also maintained higher CD4 + T-cell counts compared to other patients. Female gender, a high CD4 + T-cell count and low VL during PHI, and a high CD4 + T-cell count and low HIV DNA levels at interruption, were associated with post-ART HIV control. Treatment characteristics did not differ between controllers and non-controllers. Post-ART controllers had lower specific CD8 + T-cell frequencies and CD8 + T-cell activation on ART and after ART interruption than non-controllers. Conclusions Few patients maintain very low VL after interruption of treatment initiated during PHI. Early patient characteristics were the main factors of viral control, although early initiation of ART and the effect of ART on reservoir might contribute to control.
Ricin A-chain structural determinant for binding substrate analogues: A molecular dynamics simulation analysis (1997)

Ricin A-chain is a cytotoxic protein that attacks ribosomes by hydrolyzing a specific adenine base from a highly conserved, single-stranded rRNA hairpin containing the tetraloop sequence GAGA. Molecular-dynamics simulation methods are used to analyze the structural determinant for three substrate analogues bound to the ricin A-chain molecule. Simulations were applied to the binding of the dinucleotide adenyl-3',5'-guanosine employing the x-ray crystal structure of the ricin complex and a modeled CGAGAG hexanucleotide loop taken from the NMR solution structure of a 29-mer oligonucleotide hairpin. A third simulation model is also presented describing a conformational search of the docked 29-mer structure by using a simulated-annealing method. Analysis of the structural interaction energies for each model shows the overall binding dominated by nonspecific interactions, which are mediated by specific arginine contracts from the highly basic region on the protein surface. The tetraloop conformation of the 29-mer was found to make specific interactions with conserved protein residues, in a manner that favored the GAGA sequence. A comparison of the two docked loop conformations with the NMR structure revealed significant positional deviations, suggesting that ricin may use an induced fit mechanism to recognize and bind the rRNA substrate. The conserved Tyr-80 may play an important conformational entropic role in the binding and release of the target adenine in the active site.
Redefining Interleukin 11 as a regeneration-limiting hepatotoxin (2019)

Abstract Acetaminophen (APAP) overdose is a leading cause of untreatable liver failure. In the mouse model of APAP-induced liver injury (AILI), the administration of recombinant human interleukin 11 (rhIL11) is protective. Here we show that the beneficial effect of rhIL11 in the mouse is due to its unexpected and paradoxical inhibition of endogenous mouse IL11 activity. Contrary to the accepted paradigm IL11 is a potent hepatotoxin across species, which is secreted from damaged hepatocytes to drive an autocrine loop of NOX4 and JNK-dependent apoptosis. Mice with hepatocyte-specific Il11 expression spontaneously develop liver failure whereas those with Il11ra1 deletion are remarkably protected from AILI. Neutralizing anti-IL11R antibodies administered to moribund mice 10 hours following a lethal APAP overdose results in 90% survival that is associated with very large liver regeneration. Our data overturn a misconception, identify a new disease mechanism and suggest IL11 as a therapeutic target for liver regeneration.
Paleoshorelines and the Evolution of the Lithosphere of Mars (2006)

The existence of features indicative of shorelines of ancient oceans on Mars has been proposed for several authors. In this chapter we revise the topography of possible Martian paleoshorelines, and their consequences for the amount of water infilling ocean basins when water load is considered. We show that a re-evaluation of paleoshorelines is need. For example, the putative Meridiani shoreline could be the same feature as some portions of the Arabia shoreline. Indeed, elevations in the Meridiani shoreline are roughly similar to that of the Arabia shoreline in northeast Arabia, Utopia (not taken into account the Isidis basin), Elysium, and Amazonis regions. This is still far of an equipotential surface, but a paleoshoreline through these regions and the Meridiani horeline would be better candidate to represent a paleoequipotential surface than the Arabia shoreline sensu strito. Moreover, the elevation of the Arabia shoreline in northern Arabia Terra after is intriguingly close to the mean elevation of the Deuteronilus shoreline, and it cannot be discarded a “mixed” Arabia/Deuteronilus shoreline, which would include the Arabia shoreline in northern Arabia Terra, and the Deuteronilus shoreline elsewhere.
The significance of measurement of several oncofetal antigens in diagnosis and management of epithelial ovarian tumors. (1983)

Association of serum alphafetoprotein (alpha FP), human chorionic gonadotropin beta-subunit (beta-HCG), carcinoembryonic antigen (CEA) and ferritin (FER) was studied in a group of 72 patients with epithelial ovarian cancer 15 days after surgery and at various times during 2 years. Only CEA and ferritin are able to reflect tumor burden in detecting evolutive disease; alpha FP and beta-HCG have a diagnostic significance in few cases, probably related to a particular, not evident, histological component of the tumor. Nevertheless the data indicate that the use of marker association can improve our capacity to detect, overall in the residual and evolutive disease, the real clinical burden of the patients.
Snake-Like Units Using Flexible Backbones and Actuation Redundancy for Enhanced Miniaturization (2006)

This paper reports some recent analysis and modeling results obtained while developing a tele-robotic system for minimally invasive surgery of the throat. One of the main enabling components of this system is a Distal Dexterity Unit that implements a novel design using a flexible multi-backbone snake-like unit with actuation redundancy and push-pull actuation. The design of this snake-like unit is compared to other alternative designs that use a single flexible-backbone and wire-actuation. A unified kinematic and virtual work model is used to perform this comparison between a multi-backbone snake like unit with an equal-diameter snake-like unit using a single flexible backbone and wire actuation. The comparison is presented for several actuation redundancy resolutions that minimize the load on the flexible backbones. The results show that the multi-backbone design is superior to the alternative wire-actuated designs using a single flexible backbone. The advantages manifest in smaller required actuation forces on the backbones and, as a result, a reduced risk of buckling of the backbones and enhanced potential downsize scalability.
Polynaphthalene Networks from Bisphenols (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPolynaphthalene Networks from BisphenolsDennis W. Smith,, David A. Babb, R. Vernon Snelgrove, Paul H. Townsend, and Steven J. MartinView Author Information Central & New Businesses R&D The Dow Chemical Company Freeport, Texas 77541, and Midland, Michigan 48674 Cite this: J. Am. Chem. Soc. 1998, 120, 35, 9078–9079Publication Date (Web):August 19, 1998Publication History Received6 May 1998Published online19 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/ja981572ahttps://doi.org/10.1021/ja981572arapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1025Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Hydrocarbons,Monomers,Polymerization,Polymers Get e-Alerts
High efficiency photoluminescence from silica-coated CdSe quantum dots (2009)

The effects on the luminescent properties of coating CdSe quantum dots with silica are presented. Coating increased the quantum yields from ∼10%–20% to ∼80% at a maximum. The changes in quantum yields and photoluminescence peak at wavelength were discussed in terms of the effects of surface charge. By neutralizing surface charge, the emission from CdSe quantum dots was initially blueshifted followed by redshifting, and the quantum yield increased dramatically.