gebhart/patrepeval huggingface dataset:
Remote-plasma chemical vapor deposition of conformal ZrB2 films at low temperature: A promising diffusion barrier for ultralarge scale integrated electronics (2002)

High-quality ZrB2 thin films have been deposited at substrate temperatures as low as 300 °C by a new method: remote hydrogen-plasma chemical vapor deposition from the single-source precursor Zr(BH4)4. Carrying out the deposition in the presence of atomic hydrogen generates films with properties that are far superior to those deposited by purely thermal methods; the latter are boron-rich, oxidize readily in air, and adhere poorly to the substrates. In contrast, the films generated at a substrate temperature of 300 °C in the presence of atomic H have a B/Zr ratio of 2, a resistivity of 40 μΩ cm, an oxygen content of ⩽4 at. %, and are fully conformal in deep vias. A 20 nm thick amorphous film of ZrB2 on c-Si(001) prevents Cu indiffusion after 30 min at 750 °C. We propose that the beneficial effects of atomic hydrogen can be attributed to promoting the desorption of diborane from the growth surface.
Early pregnancy factor is an immunosuppressive contaminant of commercial preparations of human chorionic gonadotrophin. (1983)

Early pregnancy factor (EPF) is a pregnancy associated substance detected in human serum and urine throughout the first and second trimesters of pregnancy. It has also been detected in several commercial preparations of human chorionic gonadotrophin (hCG). The various molecular weight forms of EPF which occur in human pregnancy serum, urine and commercial hCG preparations have been partially characterized and found to be similar to each other but distinct from hCG. Further evidence is presented which suggests that it is EPF rather than hCG which is responsible for the immunosuppressive activity of some crude hCG preparations.
Observation of an electromagnetically induced change of absorption in multilevel rubidium atoms (1995)

A 64.4% reduction in absorption at the rubidium D2 line is observed when a pumping field at 775.8 nm is tuned on resonance to the transition between the excited states 5${\mathit{P}}_{3/2}$ and 5${\mathit{D}}_{5/2}$. As the pumping field is tuned off resonance, an absorption peak appears at the side of the Doppler-broadened D2 line. This modification in absorption is related to pumping-induced atomic coherence in this three-level ladder-type system. This experiment is done in a Rb vapor cell at room temperature and with cw diode lasers for both pumping and probe beams in a Doppler-free configuration.
Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies. (2001)

In summary, our data show high expression of IL-3 receptor a chain in hematologic malignancies. Given the high frequency of CD123 reactivity in blast cells in contrast to in normal precursors, this antigen could be applied to the study of minimal residual disease in acute leukemia. CD123 is expressed with a characteristic pattern in cases of hairy cell leukemia.
TheatzABCGenes Encoding Atrazine Catabolism Are Located on a Self-Transmissible Plasmid inPseudomonassp. Strain ADP (1998)

Pseudomonas sp. strain ADP initiates atrazine catabolism via three enzymatic steps, encoded by atzA, -B, and -C, which yield cyanuric acid, a nitrogen source for many bacteria. In-well lysis, Southern hybridization, and plasmid transfer studies indicated that the atzA, -B, and -C genes are localized on a 96-kb self-transmissible plasmid, pADP-1, in Pseudomonas sp. strain ADP. High-performance liquid chromatography analyses showed that cyanuric acid degradation was not encoded by pADP-1. pADP-1 was transferred to Escherichia coli strains at a frequency of 4.7 x 10(-2). This suggests a potential molecular mechanism for the dispersion of the atzABC genes to other soil bacteria.
Molecular dielectrophoresis of biopolymers (1994)

Dielectrophoresis (DEP) has found wide applications in manipulations of micrometer-sized particles such as biological cells. However, it has been considered less effective for nanometer-sized particles such as biological macromolecules where DEP effects may be overwhelmed by Brownian motion. Here, the authors use the fluid integrated circuit (FIC) concept to fabricate micrometer-sized electrodes, with which a very high-intensity, steady-state, high-frequency field, over 1/spl times/10/sup 6/ V/m at 1 kHz to 10 MHz, is created. The observation of molecular DEP using avidin (68 kD) and other biopolymers is made, and it is found that DEP occurs at the field strength of 0.4-1.0/spl times/10/sup 6/ V/m, which is substantially lower than DEP theory predicts. As applications of molecular DEP, a novel molecular patterning method and "dielectrophoretic chromatography" are proposed. In the latter, biopolymer solution is moved through a high-intensity field region created in a FIC, and the polymer is analyzed and/or separated by the difference in the DEP attraction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 3. Discovery of a Novel Series of N-Alkyl-N-[(fluorophenoxy)benzyl]-N‘-arylureas with Weak Toxicological Effects on Adrenal Glands (1998)

A series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas were prepared and evaluated for their ability to inhibit intestinal acyl-CoA:cholesterol O-acyltransferase and to inhibit accumulation of cholesteryl esters in macrophages in vitro. In vivo hypocholesterolemic activity was assessed in cholesterol-fed rats by oral administration as a dietary admixture and/or by gavage in a PEG400 vehicle. Modification of the alkyl substituent on the N'-aryl moiety and on the urea nitrogen significantly influenced macrophage assay in vitro. Toxicological study revealed a distinct relationship between macrophage assay and the toxicity observed in adrenal glands of rabbits treated with representatives of this series of compounds. Investigations utilizing the macrophage assay as an indicator for adrenal toxicity led to the identification of compounds 1g (FR190809) and 1k (FR186485, or FR195249 as its hydrochloride salt) as potent, nonadrenotoxic, orally efficacious ACAT inhibitors irrespective of the administration method.
Software Synthesis for Single-Processor DSP Systems Using Ptolemy (1993)

Ptolemy is an environment for simulation, prototyping and software synthesis for heterogenous systems. It uses modern object-oriented software technology (in C++) to model each subsystem in a natural and efficient manner, and to integrate these subsystems into a whole. The objectives of Ptolemy encompass practically all aspects of designing signal processing and communications systems, ranging from algorithms and communication strategies, through simulation, hardware and software design, parallel computing, to generation of real-time prototypes. In this paper I will describe the software synthesis aspects of the Ptolemy system for single-processor architectures. The environment presented here is both modular and extensible
Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures (2008)

A hydroxyl group at the C-10 position on the CBZ tricyclic structure in MHD reduces GABA(A) receptor potentiation and seizure aggravation. Reports of the aggravation of absence seizures in patients taking OXC may result from circulating unmetabolized OXC rather than MHD.
Practical Aspects of Horizontal Well Technology: A Perspective (1990)

ABSTRACT Horizontal well completions to enhance hydrocarbon recovery have increased considerably in the past several years. The success of horizontal wells appears to be related to the development and application of special technology. Documentation of new technology exists in the literature; application to date has been limited and has not always met with measurable success. A critical evaluation of the technology and its associated applications allows one to choose the most practical options and methods. This paper discusses seven specific categories of horizontal well technology: reservoir and well location selection, well planning, drilling, formation evaluation, completion and testing, stimulation and production and reservoir monitoring. In each category the practical options and techniques are presented in conjunction with specific applications. The associated discussions will allow the reader to use the information as a reference. Generic tool and technique names have been used; however, when discussing specific applications of the technology, references to Schlumberger services have been made.
Actinium: A RESTful runtime container for scriptable Internet of Things applications (2012)

Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that provides Web-like scripting for low-end devices through Cloud-based application servers and a consistent, RESTful programming model. Our novel runtime container Actinium (Ac) exposes scripts, their configuration, and their lifecycle management through a fully RESTful programming interface using the Constrained Application Protocol (CoAP). We endow the JavaScript language with an API for direct interaction with mote-class IoT devices, the CoapRequest object, and means to export script data as Web resources. With Actinium, applications can be created by simply mashing up resources provided by CoAP servers on devices, other scripts, and classic Web services. We also discuss security considerations and show the suitability of this architecture in terms of performance with our publicly available implementation.
Rexinoids for Prevention and Treatment of Cancer: Opportunities and Challenges (2016)

Rexinoids are selective ligands for the nuclear receptors known as RXRs. They do not bind to the receptors for all-trans-retinoic acid (RARs). Many new rexinoids have been synthesized and then assayed for their ability to suppress proliferation of cancer cells, to inhibit activation of inflammatory cells of the tumor microenvironment, and to prevent carcinogenesis in animal models relevant to human disease. Here we review the literature on the effects of 4 such rexinoids: bexarotene, LG100268, LG101506, and NRX194204. These rexinoids also have potent synergistic effects when used in combination with other active pharmacological agents, and practical clinical applications would benefit from these actions.
Neuregulin-1 promotes cardiomyocyte differentiation of genetically engineered embryonic stem cell clones (2008)

Embryonic stem (ES) cell-derived cardiomyocytes (ESCMs) must be specifically purified in order to prevent teratoma formation, and this confusing issue has hampered their clinical application. We therefore investigated a technique to generate pure labeled ESCMs for possible use in cardiac repair. We generated transgenic ES cell lines expressing enhanced green fluorescent protein (EGFP) under the transcriptional control of the alpha-cardiac myosin heavy chain (alpha-MHC) promoter. Differentiated EGFP-positive ES cells displayed characteristics of CMs. Furthermore, neuregulin-1 (NRG-1) upregulated the expression of the cardiac-restricted transcription factors Nkx2.5 and GATA-4, as well as differentiated CM factors (alpha-MHC, beta-MHC). Immunohistochemistry demonstrated that NRG-1 increased expression of cardiac-specific troponin T in the beating foci of the embryoid bodies. This work revealed a potential method for specifically labeling and enriching ESCMs by combining genetically-engineered ES cell clones and exogenous growth factor treatment.
Electric Field measurements in air (2010)

A recent breakthrough in non‐contacting electric field measurement at RMIT University may realistically achieve the prospect of low‐frequency Electric field measurements in the air. Prototype RMIT Electric, non‐contacting charge‐coupled (En3c) sensors, while directly‐coupled, have a bandwidth limited by audio electronic components to the 20 Hz to 20 kHz range. In testing to date, the compact sensors have lower noise than 50 m grounded electrodes and have been used in motion to collect for Audiofrequency Magnetotelluric data.
Uptake of Manganese and Cadmium from the Nasal Mucosa into the Central Nervous System via Olfactory Pathways in Rats * (1996)

In the olfactory epithelium the primary olfactory neurones are in contact with the environment and via the axonal projections they are also connected to the olfactory bulbs of the brain. Therefore, the primary olfactory neurones provide a pathway by which foreign materials may gain access to the brain. In the present study we used autoradiography and gamma spectrometry to show that intranasal instillation of manganese (54Mn2+) in rats results in initial uptake of the metal in the olfactory bulbs. The metal was then seen to migrate via secondary and tertiary olfactory pathways and via further connections into most parts of the brain and also to the spinal cord. Intranasal instillation of cadmium (109Cd2+) resulted in uptake of the metal in the anterior parts of the olfactory bulbs but not in other areas of the brain. This indicates that this metal is unable to pass the synapses between the primary and secondary olfactory neurones in the bulbs. Intraperitoneal administration of 54Mn2+ or 109Cd2+ showed low uptake of the metals in the olfactory bulbs, an uptake not different from the rest of the brain. Manganese is a neurotoxic metal which in man can induce an extrapyramidal motor system dysfunction associated with occupational inhalation of manganese-containing dusts or fumes. We propose that the neurotoxicity of inhaled manganese is related to an uptake of the metal into the brain via the olfactory pathways. In this way manganese can circumvent the blood-brain barrier and gain direct access to the central nervous system.
Oxygen in the Cultivation of Stem Cells (2005)

Cultivation of stem cells, like all cells in culture, is performed under conditions that cannot and do not replicate normal physiologic conditions. For example, direct exposure of cultured monolayer cells to serum contents is normally prevented in vivo by the vasculature. The heterogeneity of cells and signals between different cell types in an organ is certainly not captured when a single cell type is grown and studied in vitro. Gases, in particular, are not accounted for in routine tissue culture. Oxygen is fundamental for life and its concentration is an important signal for virtually all cellular processes. Nonetheless, oxygen is rarely taken into account in culturing stem and other cells. This review will summarize work that highlights the importance of considering oxygen conditions for culturing and manipulating stem cells. Emphasis is placed on major phenotypic changes in response to oxygen, recognizing that oxygen-mediated transcriptional and post-translational effects are enormously complex, and beyond the scope of this review. The review emphasizes that oxygen is an important signal in all major aspects of stem cell biology including proliferation and tumorigenesis, cell death and differentiation, self-renewal, and migration.
Biocompatibility of Poly-DL-lactic acid (PDLLA) for Lung Tissue Engineering (2006)

This study explores the possibility of growing lung cells on poly-DL-lactic acid (PDLLA) scaffolds, with a view to in future engineer pulmonary tissue for human implantation. As a first step in this process, the ability of PDLLA to maintain the growth of lung epithelium is tested using a robust cell line. Poly-DL-lactic acid has been investigated in two forms, as planar discs and as 3-D foams, and it has been demonstrated that PDLLA is not only nontoxic to pneumocytes but it also actively supports their growth. The initial findings suggest that the material is an appropriate matrix for engineering of distal lung tissue.
Specification-driven directed test generation for validation of pipelined processors (2008)

Functional validation is a major bottleneck in pipelined processor design due to the combined effects of increasing design complexity and lack of efficient techniques for directed test generation. Directed test vectors can reduce overall validation effort, since shorter tests can obtain the same coverage goal compared to the random tests. This article presents a specification-driven directed test generation methodology. The proposed methodology makes three important contributions. First, a general graph model is developed that can capture the structure and behavior (instruction set) of a wide variety of pipelined processors. The graph model is generated from the processor specification. Next, we propose a functional fault model that is used to define the functional coverage for pipelined architectures. Finally, we propose two complementary test generation techniques: test generation using model checking, and test generation using template-based procedures. These test generation techniques accept the graph model of the architecture as input and generate test programs to detect all the faults in the functional fault model. Our experimental results on two pipelined processor models demonstrate several orders-of-magnitude reduction in overall validation effort by drastically reducing both test-generation time and number of test programs required to achieve a coverage goal.
An NAD(P)H-Nicotine Blue Oxidoreductase Is Part of the Nicotine Regulon and May Protect Arthrobacter nicotinovorans from Oxidative Stress during Nicotine Catabolism (2007)

An NAD(P)H-nicotine blue (quinone) oxidoreductase was discovered as a member of the nicotine catabolic pathway of Arthrobacter nicotinovorans. Transcriptional analysis and electromobility shift assays showed that the enzyme gene was expressed in a nicotine-dependent manner under the control of the transcriptional activator PmfR and thus was part of the nicotine regulon of A. nicotinovorans. The flavin mononucleotide-containing enzyme uses NADH and, with lower efficiency, NADPH to reduce, by a two-electron transfer, nicotine blue to the nicotine blue leuco form (hydroquinone). Besides nicotine blue, several other quinones were reduced by the enzyme. The NAD(P)H-nicotine blue oxidoreductase may prevent intracellular one-electron reductions of nicotine blue which may lead to semiquinone radicals and potentially toxic reactive oxygen species.
Drinking from the Fire Hose — Statistical Issues in Genomewide Association Studies (2007)

The past 3 months have seen the publication of a series of studies examining the inherited genetic underpinnings of common diseases such as prostate cancer, breast cancer, diabetes, and in this issue of the Journal, coronary artery disease (reported by Samani et al., pages 443–453). These genomewide association studies have been able to examine interpatient differences in inherited genetic variability at an unprecedented level of resolution, thanks to the development of microarrays, or chips, capable of assessing more than 500,000 single-nucleotide polymorphisms (SNPs) in a single sample. This "SNP-chip" technology capitalizes on a catalogue of common human genetic variations that . . .
Increased prebeta-HDL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprotein A-I (apoA-I) transgenes. (1996)

The effects of cholesteryl ester transfer protein (CETP) on the distribution of apolipoprotein (apo) A-I between high density lipoprotein (HDL) subspecies and its impact on efflux and esterification of cell-derived cholesterol was studied in transgenic mice expressing either the human apoA-I (HuAITg) or both the human apoA-I and CETP (HuAICETPTg) transgenes. The simultaneous expression of the human CETP and apoA-I transgenes induced a 2-fold increase in the proportion of human apoA-I in the prebeta-HDL fraction and 1.4- and 2.2-fold increases in the HDL3a and HDL3c fractions, respectively, at the expense of the larger HDL2b population. HuAICETPTg mouse plasma has a greater ability to cause efflux of cholesterol from 3H-labeled fibroblasts than plasma from HuAITg mice. Furthermore, the LCAT-mediated esterification of cell-derived cholesterol is increased 1.7-fold in mice expressing the human apoA-I and CETP transgenes compared to HuAITg mouse plasma. LCAT activity (measured with an exogenous substrate) was increased 1.4-fold and LCAT mRNA levels were increased 1.3-fold as a result of CETP expression. Taken together, these data indicate that in vivo, the expression of CETP resulted in an increase in the proportion of apoA-I in the prebeta-HDL fraction and a stimulation of the efflux and esterification of cell-derived cholesterol.
A proposed nomenclature and classification for plant pathogenic bacteria (1978)

Abstract Many names of plant pathogenic bacteria will not be included in the Approved Lists, 1980, if the lists contain only the names of valid species. It is proposed that pathogens which do not have a claim to species rank be classified as pathovars. All validly published names of plant pathogens for which there are authentic cultures are listed here as species or as pathovars. A guide for using the term pathovar at the infrasubspecific level is suggested. Designated type and reference strains are listed, and neotype and new reference strains are suggested where none has been reported elsewhere.
Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogsB. W. Metcalf, P. Bey, C. Danzin, M. J. Jung, P. Casara, and J. P. VevertCite this: J. Am. Chem. Soc. 1978, 100, 8, 2551–2553Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ja00476a050https://doi.org/10.1021/ja00476a050research-articleACS PublicationsRequest reuse permissionsArticle Views1325Altmetric-Citations840LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Information Dissemination and Aggregation in Asset Markets with Simple Intelligent Traders (1998)

Various studies of asset markets haveshown that traders are capable of learning and transmitting information through prices in many situations. In this paper we replace human traders with intelligentsoftware agents in a series of simulated markets. Using these simple learning agents, we are able to replicate several features of the experiments with human subjects, regarding (1) dissemination of information from informed to uninformed traders, and (2) aggregation of information spread over different traders.