gebhart/patrepeval huggingface dataset:
Acetyl-L-carnitine prevents substance P loss in the sciatic nerve and lumbar spinal cord of diabetic animals. (1992)

Diabetic neuropathy is a disease of peripheral nerves, characterized by axonal atrophy and degeneration that might be preceded by a marked impairment of axonal transport and by a reduced conduction velocity. Sensory nerves are particularly susceptible to diabetes. In the present report it is shown that experimental diabetes in rats causes a significant reduction of the content of the pain-related neuropeptide substance P in sciatic nerve and lumbar spinal cord. Such a loss of substance P is fully prevented by acetyl-L-carnitine treatment. The neuroprotective pharmacological effect is selective and takes place without significant changes of hyperglycaemia and without modifications of the reduced rate of body growth typical of diabetic animals.
COMPARATIVE POLYCLONAL ANTITHYMOCYTE GLOBULIN AND ANTILYMPHOCYTE/ANTILYMPHOBLAST GLOBULIN ANTI-CD ANTIGEN ANALYSIS BY FLOW CYTOMETRY (1995)

Polyclonal antithymocyte globulin (ATGVantilym-phocyte and antilymphoblast globulins (ALG) antibodies have been used successfully in transplantation, aplastic anemia and graft-versus-host disease. Flow cytometry has been used to analyze peripheral blood lymphocyte populations in transplant patients receiving polyclonal ATG/ALG preparations for immunosuppression. Recent reports have indicated clinical dose adjustment based on levels of patient's cells expressing various CD antigens. In vitro analysis of individual polyclonal ATG/ALG CD antigen specificity could identify appropriate antigens for clinical monitoring as well as provide useful in vitro activity data. Therefore, a flow cytometry based assay to characterize and compare activities to specific CD antigens found on the surface of peripheral blood lymphocytes has been developed. Activities found in four lots each of horse ATG (ATGAM, Upjohn), rabbit and horse ATG (thymoglobulin and lymphoglobulin, Merieux), horse ALG (Minnesota), and rabbit ATG (Fresenius) have been compared for CD2, CD3, CD4, CD5, CD7, CD8, CD11a, CD18, CD28, CD44, CD45, and TCR-α/β antigens. Quantitation is achieved by measuring the concentration of ATG/ALG required to give 50% inhibition of antigen specific fluorescent-labeled monoclonal antibody relative to buffer controls. The three horse products tested have similar activity to most antigens tested. However, Fresenius rabbit ATG has the lowest activity for almost all antigens tested whereas the Merieux rabbit ATG has activities closer to the horse products. This technique allows for rapid in vitro comparison of reactivities to individual lymphocyte antigens as well as in vitro analysis of consistency.
Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe. (1991)

Loss of function of the Schizosaccharomyces pombe gap1 gene results in the same phenotypes as those caused by an activated ras1 mutation, i.e., hypersensitivity to the mating factor and inability to perform efficient mating. Sequence analysis of gap1 indicates that it encodes a homolog of the mammalian Ras GTPase-activating protein (GAP). The predicted gap1 gene product has 766 amino acids with relatively short N- and C-terminal regions flanking the conserved core sequence of GAP. Genetic analysis suggests that S. pombe Gap1 functions primarily as a negative regulator of Ras1, like S. cerevisiae GAP homologs encoded by IRA1 and IRA2, but is unlikely to be a downstream effector of the Ras protein, a role proposed for mammalian GAP. Thus, Gap1 and Ste6, a putative GDP-GTP-exchanging protein for Ras1 previously identified, appear to play antagonistic roles in the Ras-GTPase cycle in S. pombe. Furthermore, we suggest that this Ras-GTPase cycle involves the ra12 gene product, another positive regulator of Ras1 whose homologs have not been identified in other organisms, which could function either as a second GDP-GTP-exchanging protein or as a factor that negatively regulates Gap1 activity.
Developing a Functional Wayfinding System from the Existing Signage System at Madigan Army Medical Center. (1994)

Abstract : Madigan Army Medical Center, the newest Department of Defense tertiary care teaching center, was identified as having a problematic wayfinding system be several sources. Wayfinding, a relatively new term used to describe the act of processing spatial orientation cues inside an architectural facility (finding one's way), has amassed a considerable amount of literature in a short time span. A Post Occupancy Evaluation of the facility suggested further study on the issue. Two survey instruments were designed to assess the current status and magnitude of the problem and were administered throughout the entire facility. Responses from the patient and visitor survey (N1--875) and from the staff survey (N2--147) provided useful information on trends, problem areas, customer insights and preferences, and suggestions for improvement. A self assessment checklist on wayfinding found in the literature was also used to identify problem areas, validate trends in the surveys, and suggest improvements. Six courses of action were developed to address the identified problems. These alternatives were evaluated via a weighted, multicriteria decision matrix. Nineteen criteria were developed from the literature and staff input. The 'best' alternative, as identified by the decision matrix, was developed, with additional recommendations to the Executive Committee.
Adaptive network support for mobile multimedia (1995)

Owing to widespread user mobility, limited radio resources, and changing network characteristics. supporting multimedia communications in a mobile intemetworking environment is a challenging problem. In this paper; we present an "adaptive reserved service" framework for use in integrated services networks to support mobile connections carrying multimedia traffic. Reserved bandwidth in the fixed network is dynamically adjusted based on resource availability in the wireless network. Integrated in the framework are an anticipatory handoff control mechanism which enables .fast hand08 and an adaptive link partitioning scheme which enhances hand08 success. An accompanying reservation protocol not only facilitates distributed control of mobile connections but also provides network feedback to mobile hosts,
Genetic and Biochemical Basis for Viability of Yeast Lacking Mitochondrial Genomes (2002)

Yme1p, an ATP-dependent protease localized in the mitochondrial inner membrane, is required for the growth of yeast lacking an intact mitochondrial genome. Specific dominant mutations in the genes encoding the alpha- and gamma-subunits of the mitochondrial F(1)F(0)-ATPase suppress the slow-growth phenotype of yeast that simultaneously lack Yme1p and mitochondrial DNA. F(1)F(0)-ATPase activity is reduced in yeast lacking Yme1p and is restored in yme1 strains bearing suppressing mutations in F(1)-ATPase structural genes. Mitochondria isolated from yme1 yeast generated a membrane potential upon the addition of succinate, but unlike mitochondria isolated either from wild-type yeast or from yeast bearing yme1 and a suppressing mutation, were unable to generate a membrane potential upon the addition of ATP. Nuclear-encoded F(0) subunits accumulate in yme1 yeast lacking mitochondrial DNA; however, deletion of genes encoding those subunits did not suppress the requirement of yme1 yeast for intact mitochondrial DNA. In contrast, deletion of INH1, which encodes an inhibitor of the F(1)F(0)-ATPase, partially suppressed the growth defect of yme1 yeast lacking mitochondrial DNA. We conclude that Yme1p is in part responsible for assuring sufficient F(1)F(0)-ATPase activity to generate a membrane potential in mitochondria lacking mitochondrial DNA and propose that Yme1p accomplishes this by catalyzing the turnover of protein inhibitors of the F(1)F(0)-ATPase.
Untreated asymptomatic bacteriuria in girls: II--Effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections. (1989)

In girls with untreated asymptomatic bacteriuria the use of phenoxymethylpenicillin for intercurrent infections may lead to a change of urinary bacteria and leave them at substantial risk of acute pyelonephritis. With erythromycin this risk is small (2/20 courses in this series).
Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3β (2000)

Human tau-protein kinase I (TPK-I; also known as glycogen synthase kinase-3beta, GSK-3beta) is a serine/threonine protein kinase. Full-length TPK-I/GSK-3beta was expressed in Escherichia coli as a fusion protein with a 6xHis tag at the C-terminus and was crystallized using the hanging-drop vapour-diffusion method. Prismatic crystals of dimensions 0.4 x 0.2 x 0.1 mm were obtained using 12-15%(w/v) polyethylene glycol 6000 as a precipitant at 278 K. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 82.9, b = 86.1, c = 178.1 A measured at 100 K, diffract to 2.3 A resolution and seem to contain two enzyme molecules per asymmetric unit.
Randomized phase II study of PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) vs AG in patients (Pts) with untreated, metastatic pancreatic ductal adenocarcinoma (mPDA). (2017)

4008 Background: Hyaluronan (HA) accumulation in the tumor microenvironment produces elevated tumor pressure, vascular compression, and reduced drug delivery. PEGPH20 degrades HA, increasing the access and therapeutic index of anticancer agents. Methods: In Stage 1 of this phase II study, pts with untreated mPDA were randomized 1:1 to PAG (P; 3 µg/kg IV 2x/wk x 3 wks in C1, then 1x/wk x 3 wks in C2+, plus AG) vs AG every 28 days. An imbalance in thromboembolic (TE) events in the PAG arm led to a clinical hold (~40% of pts discontinued PEGPH20), exclusion of pts at high risk for TE events and enoxaparin prophylaxis in both study arms. In Stage 2, randomization was 2:1 to PAG vs AG. Tumor HA was tested using a novel assay (VENTANA HA RxDx). Primary endpoints were PFS (evaluable pts) and TE event rate (Stage 2). Secondary endpoints were PFS by HA level and ORR. Results: 279 pts were randomized; 231 are evaluable for efficacy. Of 246 pts with HA data, 84 (34%) were HA-High. As of December 16, 2016, the primary PFS endpoint was statistically significant for PAG vs AG (HR 0.73, 95% CI 0.53-1.00; p = 0.048) (Table). PFS in HA-High pts was also statistically significant in the PAG vs AG arm (HR 0.51; 95% CI 0.26-1.00; p = 0.048). ORR in HA-High pts was 46% (PAG) vs 34% (AG). Overall survival in HA-High pts (exploratory) was 11.5 months (mo) (PAG) and 8.5 mo (AG) (HR 0.96, 95% CI 0.57-1.61). TE events were similar (PAG 14% vs AG 10%) following enoxaparin initiation. All grade treatment-related AE included peripheral edema (PAG 63% vs AG 26%), muscle spasms (56% vs 3%), neutropenia (34% vs 19%), and myalgia (26% vs 7%). Conclusions: Randomized Phase II study met both primary endpoints (PFS and TE event rate), with the largest improvement in the secondary endpoint of PFS in HA-High pts. These data support HA as a potential predictive biomarker for patient selection of PEGPH20, currently investigated in the ongoing global Phase III HALO 301 study with PFS and OS as co-primary endpoints. Clinical trial information: NCT01839487. [Table: see text]
Geometric Interpretation of the Derivatives of Parallel Robots’ Jacobian Matrix With Application to Stiffness Control (2003)

This paper presents a closed-form formulation and geometrical interpretation of the derivatives of the Jacobian matrix of fully parallel robots with respect to the moving platforms’ position/orientation variables. Similar to the Jacobian matrix, these derivatives are proven to be also groups of lines that together with the lines of the instantaneous direct kinematics matrix govern the singularities of the active stiffness control. This geometric interpretation is utilized in an example of a planar 3 degrees-of-freedom redundant robot to determine its active stiffness control singularity.
Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers (2010)

Many patients elect to have repeat treatments with hyaluronic acid dermal fillers to maintain wrinkle correction, but the clinical performance of these products after repeat treatments has not been formally assessed. The primary objective of this study was to evaluate the effectiveness of Juvéderm injectable gel (Juvéderm Ultra, Juvéderm Ultra Plus, and Juvéderm 30) through 1 year after repeat treatment of nasolabial folds (NLFs) that were previously treated with Juvéderm or Zyplast 6-9 months prior to the repeat treatment. Upon completion of the pivotal IDE clinical trial for Juvéderm, five of the original 11 study sites were selected to participate in an extended follow-up evaluation, and a total of 80 subjects were enrolled. For the Juvéderm-treated NLFs in each treatment group, the median injection volume was 1.5-1.6 mL for initial treatment but only 0.5-0.6 mL for the repeat treatment (p < 0.0001). Mean Investigator-assigned NLF severity scores on a scale of 0-4 for the Juvéderm-treated NLFs improved from 2.5-2.7 (moderate to severe) at baseline to 1.2-1.5 (mild) just prior to repeat treatment (>24 weeks) and 0.7-0.9 (mild) at 4 weeks after repeat treatment. At 48 weeks post-repeat treatment, the mean NLF scores were 1.1-1.3 (mild), and 78-90% of subjects were considered responders (≥1 point improvement). Thus, subjects sustained a total of 18-21 months of wrinkle correction with a repeat treatment at 6-9 months and needed substantially less filler (60% less) for repeat treatment than for initial treatment, indicating that retreatment at this timepoint may be beneficial to patients.
Exu - A System for Secure Delegation of Authority on an Insecure Network (1995)

Administration of a large and complex system poses several problems: Usually, some tasks must be delegated due to lack of qualified or trusted staff, and some tasks must be automated. In many cases, some parts of the task might need special credentials, such as Kerberos tickets or AFS tokens, that may not necessarily be easily available to the person executing the task. The problem is that most systems divide users into two groups: haves and have nots, and provide no mechanism for finer-grained access control. In addition, the tasks executed must be carefully recorded for possible later auditing. Earlier solutions, such as the setuid bit, Moira, ADM, and sysctl, can be used to accomplish this, either in a limited or dangerous (in the case of setuid) fashion. Exu proposes to solve the problem via secure, authenticated connection to a server with full authentication that can cause things to happen in real time.
Development of Functionally innovative 3D-Integrated Circuit (Dream Chip) technology / High-Density 3D-Integration Technology for Multifunctional Devices (2009)

In the NEDO ldquoDream Chip Projectrdquo, ASET has been entrusted a project for developing, ldquoHigh-Density 3D-Integration Technology for Multifunctional Devicesrdquo. In the five year project from 2008 to 2012, development on technologies for design environment, interposer, chip test, cooling and stacking/bonding, thin wafer, and development on demonstration device and process are being performed.
Topology aggregation for hierarchical routing in ATM networks (1995)

This paper provides a tutorial for topology arregation in large hierarchical communication networks. Specifically, it examines some issues of topology aggregation for hierarchical PNNI Routing in ATM networks, presents a complex node representation, and provides some guidelines for topology aggregation. There are two main reasons for topology aggregation. First, topology information must be compressed to avoid excessive complexity in topology adevertisement. Second, the internal topology of a network may have to be hidden for security reasons. A desirable topology aggregation method must adequately represent the topology of a given network for efficient routing and netowrk resource allocation, using a compact advertised topology.
Crystallographic and mutational analyses of an extremely acidophilic and acid-stable xylanase: biased distribution of acidic residues and importance of Asp37 for catalysis at low pH (1998)

Xylanase C from Aspergillus kawachii has an optimum pH of 2.0 and is stable at pH 1.0. The crystal structure of xylanase C was determined at 2.0 A resolution (R-factor = 19.4%). The overall structure was similar to those of other family 11 xylanases. Asp37 and an acid-base catalyst, Glu170, are located at a hydrogen-bonding distance (2.8 A), as in other xylanases with low pH optima. Asp37 of xylanase C was replaced with asparagine and other residues by site-directed mutagenesis. Analyses of the wild-type and mutant enzymes showed that Asp37 is important for high enzyme activity at low pH. In the case of the asparagine mutant, the optimum pH shifted to 5.0 and the maximum specific activity decreased to about 15% of that of the wild-type enzyme. On structural comparison with xylanases with higher pH optima, another striking feature of the xylanase C structure was found; the enzyme has numerous acidic residues concentrated on the surface (so-called 'Ser/Thr surface' in most family 11 xylanases). The relationship of the stability against extreme pH conditions and high salt concentrations with the spatially biased distribution of charged residues on the proteins is discussed.
Determining WWW user's next access and its application to pre-fetching (2002)

World-Wide Web (WWW) services have grown to levels where significant delays are expected to happen. Prefetching techniques are likely to help reduce waiting times. However pre-fetching is only effective if the right documents are identified and if user's move is correctly predicted. Therefore, it is productive to determine whether a revisit will occur or not, before starting pre-fetching. In this paper we develop two user models that help determine user's next move. One model uses random walk approximation and the other is based on digital signal processing techniques. We also give hints on how to use such models with a simple pre-fetching technique that we are developing.
<title>A new compressive imaging camera architecture using optical-domain compression</title> (2006)

<i>Compressive Sensing</i> is an emerging field based on the revelation that a small number of linear projections of a compressible signal contain enough information for reconstruction and processing. It has many promising implications and enables the design of new kinds of <i>Compressive Imaging</i> systems and cameras. In this paper, we develop a new camera architecture that employs a digital micromirror array to perform optical calculations of linear projections of an image onto pseudorandom binary patterns. Its hallmarks include the ability to obtain an image with a single detection element while sampling the image fewer times than the number of pixels. Other attractive properties include its universality, robustness, scalability, progressivity, and computational asymmetry. The most intriguing feature of the system is that, since it relies on a single photon detector, it can be adapted to image at wavelengths that are currently impossible with conventional CCD and CMOS imagers.
"Pray before you step out" (2013)

Personal navigation tools have greatly impacted the lives of people with vision impairments. As people with vision impairments often have different requirements for technology, it is important to understand users' ever-changing needs. We conducted a formative study exploring how people with vision impairments used technology to support navigation. Our findings from interviews with 30 adults with vision impairments included insights about experiences in Orientation & Mobility (O&M) training, everyday navigation challenges, helpful and unhelpful technologies, and the role of social interactions while navigating. We produced a set of categorical data that future technologists can use to identify user requirements and usage scenarios. These categories consist of Personality and Scenario attributes describing navigation behaviors of people with vision impairments. We demonstrate the usefulness of these attributes by introducing navigation-style personas backed by our data. This work demonstrates the complex choices individuals with vision impairments undergo when leaving their home, and the many factors that affect their navigation behavior.
Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons (1991)

Receptor channels activated by glutamate, an excitatory neurotransmitter in the mammalian brain, are involved in processes such as long-term potentiation and excitotoxicity. Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade. The whole-cell current response to glutamate and kainate [a non-NMDA (N-methyl-D-aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase. Single-channel analysis revealed that an adenosine 3',5'-monophosphate-dependent protein kinase (PKA) increases the opening frequency and the mean open time of the non-NMDA-type glutamate receptor channels. Analysis of synaptic events indicated that forskolin, acting through PKA, increased the amplitude and decay time of spontaneous excitatory postsynaptic currents.
BACTERIAL DNA AND IMMUNO-STIMULATING OLIGODEOXYNUCLEOTIDES AS MODULATING AND THERAPEUTIC AGENTS IN EXPERIMENTAL SHOCK. (1999)

Institute of Medical Microbiology, Hygiene, Philipps-University of Marburg, Pilgrimstein 2, D-35037 Marburg, Germany
Measurements of the dielectric properties of explosives and inert materials at millimeter wave frequencies (V-band and above) using free space reflection methods (2017)

We present a free space material measurement system operating in the E band (60-90 GHz) frequency range that uses calibration standards placed at the sample location to define the measurement reference plane directly at the sample surface. Measurement signal to noise is improved by using an aperture in radar absorbing material (RAM) to simplify the RF measurement environment. Measurements are provided that extend earlier work done in the 18-40 GHz frequency range. Data is extracted using numerical fitting of reflection-only data to a theoretical model based on geometric optics. System calibration, and results are presented.
Double-hit lymphomas: current paradigms and novel treatment approaches (2014)

Double-hit lymphomas (DHLs) are a heterogeneous group of mature B-cell lymphomas that harbor concurrent rearrangements of MYC and BCL2 or, occasionally, BCL6. Several studies have now shown that they are associated with a very aggressive clinical course and poor outcome after standard R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy, with few patients surviving beyond 2 years. Due to their rarity, there is a paucity of data evaluating patient outcomes with alternative strategies to R-CHOP and no consensus on how they should be optimally managed. Recent studies have demonstrated that a significant proportion of diffuse large B-cell lymphoma (DLBCL) cases have high protein expression of MYC and BCL2 as detected by IHC. These so-called "double-expressor" DLBCLs are also associated with a poor outcome after R-CHOP, even when MYC and BCL2 rearrangements are absent. There is much interest in developing new strategies for DHL and better characterizing the underlying biology that drives their poor prognosis. Alternative chemotherapy platforms to R-CHOP, such as DA-EPOCH-R (dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab), are under investigation for MYC-rearranged DLBCL, including DHL, and several novel small-molecule inhibitors of MYC and BCL2 are in development.