gebhart/patrepeval huggingface dataset:
B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex (2018)

GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown. Although B cells do not express GARP at baseline, we found that the GARP-TGF-β complex is induced on activated human and mouse B cells by ligands for multiple TLRs, including TLR4, TLR7, and TLR9. GARP overexpression on B cells inhibited their proliferation, induced IgA class-switching, and dampened T cell-independent antibody production. In contrast, B cell-specific deletion of GARP-encoding gene Lrrc32 in mice led to development of systemic autoimmune diseases spontaneously as well as worsening of pristane-induced lupus-like disease. Canonical TGF-β signaling more readily upregulates GARP in Peyer patch B cells than in splenic B cells. Furthermore, we demonstrated that B cells are required for the induction of oral tolerance of T cell-dependent antigens via GARP. Our studies reveal for the first time to our knowledge that cell surface GARP-TGF-β is an important checkpoint for regulating B cell peripheral tolerance, highlighting a mechanism of autoimmune disease pathogenesis.
Fiber-Optic Temperature Sensor Using Fluorescence Decay Time (1984)

Many different principles for temperature measurement with fiber-optic sensors have been suggested and brought about experimentally. If we restrict ourselves to the use of sensors employing fluorescence decay time, the first proposal was made by K.A. James et al. (1). They suggest exciting fluorescence by a flash and measuring the intensity of the decaying fluorescent light and determining the point of time at which the intensity has decreased to 1/e of the starting value. Except if laser flashes are used for excitation, measurement according to this principle will surely be very inaccurate as a result of noise. McCormack (2) sinusoidally modulates the exciting light with a fixed frequency and measures the phase shift of the fluorescent light sinusoidally oscillating at the same frequency. The accuracy achievable referred to the intensity of the exciting light is probably better; however, it is difficult to measure any phase shift very exactly.
Induction of protective immunity in swine by recombinant bamboo mosaic virus expressing foot-and-mouth disease virus epitopes (2007)

Chimeric BaMV virions that express partial sequence of FMDV VP1 can effectively induce not only humoral and cell-mediated immune responses but also full protection against FMDV in target animals. This BaMV-based vector technology may be applied to other vaccines that require correct expression of antigens on chimeric viral particles.
Lung carcinoma in former smokers (1996)

These results indicate that smoking cessation or less life-time smoking exposure affects the distribution of specific histologic subtypes of lung cancer, especially for women, and that smoking cessation may postpone the age at which lung cancer occurs.
Isodimorphism in bacterial poly(β-hydroxybutyrate-co-β-hydroxyvalerate) (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsodimorphism in bacterial poly(β-hydroxybutyrate-co-β-hydroxyvalerate)Terry L. Bluhm, Gordon K. Hamer, Robert H. Marchessault, Colin A. Fyfe, and Richard P. VereginCite this: Macromolecules 1986, 19, 11, 2871–2876Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/ma00165a035https://doi.org/10.1021/ma00165a035research-articleACS PublicationsRequest reuse permissionsArticle Views857Altmetric-Citations356LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A (1995)

IL-5 was produced in vitro by peripheral blood mononuclear cells (PBMC) of mite-sensitive atopic patients upon challenge with specific allergen, while PBMC of healthy controls produced essentially no IL-5. Stimuli delivered by the combination of phorbol ester and Ca2+ ionophore induced marked IL-5 production by PBMC obtained from atopic and non-atopic asthmatics, suggesting that both protein kinase C and Ca2+ influx are required for IL-5 production. CD2- or CD4-bearing cell depletion almost completely removed IL-5-producing cells while CD8-bearing cell depletion rather enriched them. These findings indicate that CD4+ T cells are the principal source of IL-5 in PBMC. The capacity of PBMC of atopic asthmatics, non-atopic asthmatics and healthy controls to produce IL-2, IL-4, IL-5 and IFN-gamma was compared, to find that cytokine-producing capacities other than that of IL-5 (IL-2, IL-4 and IFN-gamma) were not significantly different among the three groups. Dexamethasone, FK506 and cyclosporin A suppressed IL-5 production in vitro in a dose-dependent manner. Clear dose-dependent suppression of IL-5 gene expression by FK506 was also observed. Treatment of asthmatic patients with inhaled glucocorticoid (beclomethasone dipropionate) ameliorated clinical symptoms, improved lung function and markedly suppressed IL-5 production by PBMC, suggesting the essential role of IL-5 in the pathogenesis of bronchial asthma and the clinical importance of its regulation.
Ultra-low-power carrier-depletion Mach-Zehnder silicon optical modulator (2012)

We demonstrate a 26 Gbit/s Mach-Zehnder silicon optical modulator. The doping concentration and profile are optimized, and a modulation efficiency with the figure of merit (VπL) of 1.28 V·cm is achieved. We design an 80-nm-wide intrinsic silicon gap between the p-type and n-type doped regions to reduce the capacitance of the diode and prevent the diode from working in a slow diffusion mode. Therefore, the modulator can be driven with a small differential voltage of 0.5 V with no bias. Without the elimination of the dissipated power of the series resistors and the reflected power of the electrical signal, the maximum power consumption is 3.8 mW.
Fields in extended cavity lasers (1988)

The electromagnetic fields for an extended-cavity laser are described precisely and in detail. The extended-cavity laser consists of a semiconductor laser diode with a partially reflecting coating on one facet and an antireflection coating on the other coupled by radiation through a lensed-fiber, single-mode guide to another partially reflecting coating terminating a narrow-wavelength filter. The formulation is based on the Lorentz reciprocity theorem, the fields are described by angular plane-wave spectra, and the equivalent transmission line representation is used to determine the fields reflected and transmitted by partially reflecting and antireflection coatings. The design of antireflection coatings is considered in detail, and a formula which gives the optimum distance from the diode antireflection coating to an inline lensed fiber is derived.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
New Instruments for Catheterization and Anqiocardioqraphy (1965)

Continuous improvements of the instruments used in angiocardiography are of great importance for the extension of possibilities of examination and for the safety of such examination. Catheters for the Injection of Contrast Medium into the Right and Left Ventricles Some of the risks connected with the selective injection of contrast medium into the heart cavities have been discussed in earlier works (1, 3). Under certain conditions quick injections of contrast fluid into the heart cavities may result in a perforation of the heart wall by the jets of contrast material (4). This appears to be the case when a catheter with open terminal hole is used and its tip is resting against the wall of the heart. The axially flowing stream of fluid through the tip of the catheter seems to have considerable penetrative force. Further, the stream through the terminal hole may easily cause an appreciable recoil of the catheter, so that the contrast medium may be deposited at a point in the heart or in a vessel other than that intended. The recoil of the catheter, if it takes place in a ventricle, may also give rise to rhythm disturbances of the heart. Such considerations led to the construction of the so-called recoil-proof catheter (2) with multiple lateral holes near the completely closed tip. In this way it was possible to practically eliminate the recoil of the catheter even with a quick injection of contrast medium. Because the tip of the catheter is closed, however, it is not possible to introduce it with the percutaneous catheterization technic of Seldinger (5). As the percutaneous catheterization technic has offered many advantages, the author has in recent years been using catheters with terminal hole and multiple lateral holes near the tip, while the recoilproof catheter with closed tip has been used only sporadically. A possibility of closing the terminal hole of a catheter introduced percutaneously (Seldinger technic) has been communicated by Tornvall (6). He introduces in the lumen of the catheter a steel wire, terminally provided with a knob or cylinder occluding the terminal hole. The drawbacks of this device are: first, the wire occupies a part of the lumen, with consequent increased resistance to the injection of contrast medium and, second, the catheter will acquire a stiffness or rigidity which may imply a considerable disadvantage when introduced into a heart cavity. It would seem that catheters with too much stiffness cause rhythm disturbances more easily than do soft ones. They are probably also more apt to bring about valvular insufficiency through displacement of a valvular leaflet. In order, if possible, to combine the advantages of the percutaneous catheterization technic with those of the recoilproof catheter with closed tip, a new catheter made of radiodense Teflon has been constructed (Fig. 1, A). This is in the first place intended to be used for the injection of contrast medium into the right ventricle. It has a terminal hole and, about 6 cm proximal to this, a lateral hole.
An information fidelity criterion for image quality assessment using natural scene statistics (2005)

Measurement of visual quality is of fundamental importance to numerous image and video processing applications. The goal of quality assessment (QA) research is to design algorithms that can automatically assess the quality of images or videos in a perceptually consistent manner. Traditionally, image QA algorithms interpret image quality as fidelity or similarity with a "reference" or "perfecft" image in some perceptual space. Such "full-referenc" QA methods attempt to achieve consistency in quality prediction by modeling salient physiological and psychovisual features of the human visual system (HVS), or by arbitrary signal fidelity criteria. In this paper, we approach the problem of image QA by proposing a novel information fidelity criterion that is based on natural scene statistics. QA systems are invariably involved with judging the visual quality of images and videos that are meant for "human consumption." Researchers have developed sophisticated models to capture the statistics of natural signals, that is, pictures and videos of the visual environment. Using these statistical models in an information-theoretic setting, we derive a novel QA algorithm that provides clear advantages over the traditional approaches. In particular, it is parameterless and outperforms current methods in our testing. We validate the performance of our algorithm with an extensive subjective study involving 779 images. We also show that, although our approach distinctly departs from traditional HVS-based methods, it is functionally similar to them under certain conditions, yet it outperforms them due to improved modeling. The code and the data from the subjective study are available at.
The Influence of Interleukin Gene Polymorphism on Expression of Interleukin–1β and Tumor Necrosis Factor–α in Periodontal Tissue and Gingival Crevicular Fluid (1999)

These data suggest that PAG(+) patients may demonstrate phenotypic differences as indicated by elevated levels of IL-1beta in GCF.
Wall-modeled large eddy simulation of shock/turbulent boundary-layer interaction in a duct (2011)

International audience
An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect (1996)

Multimerin is a massive soluble, multimeric protein found in platelets and endothelial cells. Recent studies identified multimerin as a specific coagulation factor V binding protein, complexed with platelet, but not plasma, factor V. These findings led us to investigate individuals with inherited factor V deficiencies for possible multimerin abnormalities. Platelet proteins were evaluated using immunoassays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblotting, immunoprecipitation, and direct binding studies. Patients with factor V Quebec, a disorder with abnormal platelet factor V, had a quantitative deficiency in multimerin (n = 11 tested; mean, 12.5%; range, 5% to 27% of the normal pool; normal range, 45% to 214%) with a normal multimer pattern. Quantitative and qualitative abnormalities were detected in their platelet factor V. An unrelated patient who was deficient in platelet and plasma factor V had normal platelet multimerin. The levels of platelet beta-thromboglobulin, von Willebrand factor, thrombospondin, and fibrinogen antigen were normal in the factor V Quebec patients. However, proteins with abnormal mobility were detected in their platelet lysate and releasate, and their platelet thrombospondin, von Willebrand factor, and fibrinogen showed evidence of proteolytic degradation. Platelet counts of the factor V Quebec patients ranged from mildly thrombocytopenic to low normal (mean, 159 x 10(9)/L; range, 104 to 198 x 10(9)/L). In addition, their platelets failed to aggregate in response to 6 to 10 micromol/L epinephrine despite normal numbers of platelet alpha 2-adrenergic receptors. These data indicate that patients with factor V Quebec have an inherited bleeding disorder distinct from other platelet disorders and associated with multiple abnormalities, including multimerin deficiency, abnormal platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen, and an epinephrine aggregation defect.
Isolation of functional human coagulation factor V by using a hybridoma antibody. (1981)

Spleen cells obtained from mice immunized with partially purified human coagulation Factor V were fused with NS-1 mouse myeloma cells, and hybrids were selected. Culture media were screened for anti-Factor V activity, and an antibody-positive clone was obtained and passaged as an ascites tumor in mice. The ascitic fluid from the hybridoma-bearing mouse could be diluted 1:10(6) before losing reactivity in an anti-Factor V radioimmunoassay. When immobilized on agarose, the monoclonal antibody quantitatively removed Factor V activity from human plasma. Factor V activity could be eluted with 1.2 M NaCl at pH 6.5. Homogeneous Factor V was isolated by chromatography of barium citrate-adsorbed, polyethylene glycol 6000 precipitated plasma on the antibody column followed by chromatography on phenyl-Sepharose. The isolated Factor V exhibited a single band upon gel electrophoresis in sodium dodecyl sulfate with an apparent Mr comparable to that of bovine Factor V (330,000). Upon exposure to thrombin, the activity of Factor V increased 53-fold when measured in Factor V-deficient plasma. This increased activity was associated with discrete proteolytic cleavages of the parent molecule.
Nucleation and Growth of Germanium Nanowires Seeded by Organic Monolayer-Coated Gold Nanocrystals (2002)

Germanium nanowires, ranging from 10 to 150 nm in diameter, were grown several micrometers in length in cyclohexane heated and pressurized above its critical point. Alkanethiol-protected gold nanocrystals, either 2.5 or 6.5 nm in diameter, were used to seed wire formation. Growth proceeded through a solution-liquid-solid mechanism at growth temperatures ranging from 300 to 450 degrees C. At temperatures exceeding 500 degrees C, large Ge particulates formed due to unfavorable growth kinetics. Temperature, the nature of the precursor, precursor concentration, and the Au:Ge ratio were determining factors in nanowire morphology. The Ge nanowires were characterized using a range of techniques, including XPS, XRD, high-resolution TEM and SEM, nanometer-scale EDS mapping, and DTA.
Induction of T4 DNA ligase in a recombinant strain of Escherichia coli (1989)

The kinetics of cell growth and foreign protein production, as well as factors affecting protein stability, were studied and optimized in batch and fed-batch fermentations of a recombinant strain of Escherichia coli. The pL promoter from bacteriophage lambda under the control of a temperature-sensitive cl represser, with the entire construct integrated into the E. coli chromosome through the use of a defective bacteriophage lambda lysogen, was used to direct the synthesis of T4 DNA ligase. The biphasic fermentations consisted of a primary growth phase at 30 degrees C followed by an induction phase which was initiated by shifting the temperature to 42 degrees C. In the fed-batch fermentations, additional nutrients were added at the time of initiating induction. Maintenance of sufficiently high concentrations of the organic substrates (glucose and casamino acids) during the induction phase was required for continued cell growth at 42 degrees C. Such growth was essential for T4 DNA ligase formation and in vivo stability. Hence, fed-batch fermentations produced the highest yield of the foreign protein Commensurate with providing lower total amounts of substrates. In such cases, high cell densities (6 g dry wt/L) with substantial intracellular levels of T4 DNA ligase (4.6% total cellular protein, or 2.7% of the dry biomass) were achieved.
General Strategy for Broadband Coherent Perfect Absorption and Multi-wavelength All-optical Switching Based on Epsilon-Near-Zero Multilayer Films (2016)

We propose a general, easy-to-implement scheme for broadband coherent perfect absorption (CPA) using epsilon-near-zero (ENZ) multilayer films. Specifically, we employ indium tin oxide (ITO) as a tunable ENZ material, and theoretically investigate CPA in the near-infrared region. We first derive general CPA conditions using the scattering matrix and the admittance matching methods. Then, by combining these two methods, we extract analytic expressions for all relevant parameters for CPA. Based on this theoretical framework, we proceed to study ENZ CPA in a single layer ITO film and apply it to all-optical switching. Finally, using an ITO multilayer of different ENZ wavelengths, we implement broadband ENZ CPA structures and investigate multi-wavelength all-optical switching in the technologically important telecommunication window. In our design, the admittance matching diagram was employed to graphically extract not only the structural parameters (the film thicknesses and incident angles), but also the input beam parameters (the irradiance ratio and phase difference between two input beams). We find that the multi-wavelength all-optical switching in our broadband ENZ CPA system can be fully controlled by the phase difference between two input beams. The simple but general design principles and analyses in this work can be widely used in various thin-film devices.
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity (2002)

Intrarenal injection of phenol in rats causes a persistent elevation in blood pressure (BP) and in norepinephrine (NE) secretion from the posterior hypothalamus (PH), and downregulation of neuronal nitric oxide synthase (nNOS) and interleukin-1beta (IL-1beta) in the PH. These studies suggest that afferent impulses from the kidney to the brain may be responsible for hypertension associated with renal injury. Downregulation of nNOS and IL-1beta, two modulators of sympathetic nervous system (SNS) activity may mediate this activation. In this study we measured the effects of intrarenal phenol injection on peripheral SNS activity by direct renal nerve recording, plasma NE, nNOS, and IL-1beta abundance in the brain. We also determined whether renal denervation or administration of clonidine prevented these effects of phenol. Acutely, the phenol injection increased both afferent and efferent renal sympathetic nerve activity, decreased urinary sodium excretion, and increased plasma NE. Three weeks after the phenol injection, BP and plasma NE remained elevated. Renal denervation and pretreatment with clonidine prevented the increase in BP and plasma NE caused by phenol. Chronic renal injury caused by phenol was associated with decreased abundance of IL-1beta and nNOS in the PH. These studies have shown that a renal injury caused by phenol injection increases BP and central as well as peripheral SNS activity, which persist long after the injury. Renal denervation and antiadrenergic drugs abolish the effects of phenol on BP and plasma NE. Because NO and IL-1beta modulate SNS activity, the stimulatory action of phenol on the SNS could be mediated by downregulation of nNOS and IL-1beta in the brain.