gebhart/patrepeval huggingface dataset:
FLAVOR ASSOCIATED WITH FISH MEAL IN DIETS FED TO BROILER CHICKENS (1969)

Diets containing varying levels of fish meal (3–19%) were fed to broiler chickens representing male and female birds of four different genotypes. After slaughter and processing, sample birds were roasted without seasoning, and portions of skin, breast meat and thigh meat were submitted to a taste panel of nine judges. Each portion was tested by asking one of the judges to identify it when it was presented along with two comparable portions taken from a control bird. There were 720 such triangle tests, comprised of six replicate tests within each of the 120 subclasses denned by genotype, sex, nutritional treatment and type of tissue.Flavor differences between birds fed 3% and 9% fish meal were detected with a frequency which was highly significant in skin and breast meat, but in thigh meat there was no significant effect on flavor until the level of fish meal reached 14%. Neither sex nor genotype had any influence on the detection of flavor differences. The practical significance of these findings is discussed.
Ullmann Diaryl Ether Synthesis: Rate Acceleration by 2,2,6,6-Tetramethylheptane-3,5-dione (2002)

[reaction: see text]. In the copper salt catalyzed ether formation from aryl bromides or iodides and phenols, 2,2,6,6-tetramethylheptane-3,5-dione (TMHD) was found to greatly accelerate the ordinarily difficult reaction, making it occur under more moderate temperatures and reaction times. A series of aryl halides and phenols were shown to form ethers in NMP as the solvent, cesium carbonate as the base, and CuCl and TMHD as the catalysts. The reaction was shown to tolerate electron-rich aryl bromides and electron-neutral phenols.
Granulocyte Inflammatory Markers and Airway Infection during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (2001)

There is increasing evidence that chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation in the airways and lung parenchyma; however, little is known about the inflammatory response during acute COPD exacerbation. The objectives of this study were (1) to determine if inflammatory markers associated with neutrophilic inflammation and activation increase at times of acute COPD exacerbation relative to the clinically stable state, and (2) to determine whether the presence of acute bacterial or viral infection at the time of COPD exacerbation could be correlated with increases in sputum markers of inflammation. Induced sputum was collected from patients with COPD when they were clinically stable, during the time of an acute exacerbation, and 1 mo later. Sputum was analyzed at each time point for soluble markers associated with neutrophilic inflammation; myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-8 (IL-8). Serologic assays on acute and convalescent sera were performed for respiratory viruses, and induced sputum was also subject to quantitative bacterial cultures, viral cultures, and polymerase chain reaction (PCR) for detection of respiratory viruses. Fourteen of the 50 patients enrolled in the study met predetermined criteria for an acute COPD exacerbation over the 15-mo study period. TNF-alpha and IL-8 were significantly elevated in the sputum of patients during acute COPD exacerbation compared with when they were clinically stable (p = 0.01 and p = 0.05, respectively). Concentrations of these cytokines declined significantly 1 mo after the exacerbation. Three of 14 patients (21%) had confirmed bacterial or viral respiratory tract infections. Patients with documented infection did not demonstrate greater increases in sputum levels of inflammatory cytokines during exacerbations compared with patients without demonstrable infection. We conclude that markers of airway neutrophilic inflammation increase at the time of acute COPD exacerbation and then decline 1 mo later, and that this acute inflammatory response appears to occur independently of a demonstrable viral or bacterial airway infection.
The cell biology of aging (2015)

One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal--a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts. We now have evidence that aging is instead at least in part genetically regulated. Many mutations have been discovered to extend lifespan in organisms of all complexities, from yeast to mammals. The study of metazoan model organisms, such as Caenorhabditis elegans, has been instrumental in understanding the role of genetics in the cell biology of aging. Longevity mutants across the spectrum of model organisms demonstrate that rates of aging are regulated through genetic control of cellular processes. The regulation and subsequent breakdown of cellular processes represent a programmatic decision by the cell to either continue or abandon maintenance procedures with age. Our understanding of cell biological processes involved in regulating aging have been particularly informed by longevity mutants and treatments, such as reduced insulin/IGF-1 signaling and dietary restriction, which are critical in determining the distinction between causes of and responses to aging and have revealed a set of downstream targets that participate in a range of cell biological activities. Here we briefly review some of these important cellular processes.
Dramatic Tuning of Carbon Dioxide Uptake via Metal Substitution in a Coordination Polymer with Cylindrical Pores (2008)

A series of four isostructural microporous coordination polymers (MCPs) differing in metal composition is demonstrated to exhibit exceptional uptake of CO2 at low pressures and ambient temperature. These conditions are particularly relevant for capture of flue gas from coal-fired power plants. A magnesium-based material is presented that is the highest surface area magnesium MCP yet reported and displays ultrahigh affinity based on heat of adsorption for CO2. This study demonstrates that physisorptive materials can achieve affinities and capacities competitive with amine sorbents while greatly reducing the energy cost associated with regeneration.
Reversal of the Pickwickian Syndrome by Long-Term Use of Nocturnal Nasal-Airway Pressure (1982)

Chronic hypercapnia and daytime hypersomnolence in the obese patient without intrinsic lung disease — the so-called Pickwickian syndrome — has long been associated with periodic breathing.1 The recognition that obstructive sleep apnea with functional upper-airway obstruction is the mechanism of such periodic breathing2 has led to its implication in the development of chronic hypercapnia. The current definitive treatment for severe obstructive sleep apnea is tracheostomy.3 However, medical and psychosocial problems frequently interfere with the acceptance of tracheostomy by both patient and physician, especially when symptoms have been long-standing.3 , 4 Recently, a noninvasive therapeutic method — continuous positive airway pressure applied through . . .
The Comparative Solvatochromism of Arylazo and Heteroarylazo Compounds Based On N,N‐Diethyl‐m‐acetylaminoaniline and N,N‐Diethyl‐m‐toluidine (1997)

Abstract Azobenzene dyes derived from various anilines and aminothiaheterocycles azo‐coupled with commercially important N,N ‐diethyl‐ m ‐toluidine ( T series) and N,N ‐diethyl‐ m ‐acetylaminoani‐line ( A series) are positively solva‐tochromic. The visible spectra of 16 pairs of derivatives have been measured in up to 22 solvents, and the transition energies related to Kamlet‐Taft solvent polarity parameters. In general, A ‐series dyes are more bathochromic than their T ‐series counterparts in nonpolar solvents, consistent with colour chemistry tradition. However, in more dipolar solvents the more bathochromic T ‐series representatives unexpectedly become more bathochromic than their A ‐series partners. The relative solvatochromic shifts of the A and T series are related to their respective dipole moments. These in turn are distinguished by the effect of the anilide carbonyl group dipole moment, which is antiparallel to, and thus reduces, the dipole moment of the chromogen.
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma (2004)

A high serum level of VEGF is a predictor of poor outcome after resection of HCC. Serum VEGF, but not endostatin, may be a useful prognostic marker in patients with HCC.
Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or CD44, a Hyaluronan Receptor (2008)

The complex system involved in the synthesis, degradation and binding of the high molecular weight glycosaminoglycan hyaluronic acid (hyaluronan or HA) provides a variety of structures that can be exploited for targeted cancer therapy. In many cancers of epithelial origin there is an upregulation of CD44, a receptor that binds HA. In other cancers, HA in the tumor matrix is overexpressed. Both CD44 on cancer cells and HA in the matrix have been targets for anticancer therapy. Even though CD44 is expressed in normal epithelial cells and HA is part of the matrix of normal tissues, selective targeting to cancer is possible. This is because macromolecular carriers predominantly extravasate into the tumor and not normal tissue; thus CD44-HA targeted carriers administered intravenously localize preferentially into tumors. Anti-CD44 antibodies have been used in patients to deliver radioisotopes or mertansine for treatment of CD44 expressing tumors. In early phase clinical trials, patients with breast or head and neck tumors treated with anti-CD44 conjugates experienced stabilized disease. A dose-limiting toxicity was associated with distribution of the antibody-drug conjugate to the skin, a site in the body with a high level of CD44. HA has been used as a drug carrier and a ligand on liposomes or nanoparticles to target drugs to CD44 overexpressing cells. Drugs can be attached to HA via the carboxylate on the glucuronic acid residue, the hydroxyl on the N-acetylglucosamine or the reducing end which are located on a repeating disaccharide. Drugs delivered in HA-modified liposomes exhibited excellent antitumor activity both in vitro and in murine tumor models. The HA matrix is also a potential target for anticancer therapies. By manipulating the interaction of HA with cell surface receptors, either by degrading it with hyaluronidase or by interfering with CD44-HA interactions using soluble CD44 proteins, tumor progression was blocked. Finally, cytotoxic drugs or prodrug converting enzymes can be attached to the HA matrix to generate a cytotoxic fence around the tumor. This review describes how the complex interplay among cancer biology, the CD44-HA interaction, drug carriers and drug targeting has been used to improve anticancer therapies. As these approaches evolve, they hold forth the prospect of significantly improved targeted anticancer treatments.
Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy (2015)

Colorectal cancers with microsatellite instability (MSI) represent 15% of all colorectal cancers, including Lynch syndrome as the most frequent hereditary form of this disease. Notably, MSI colorectal cancers have a higher density of tumor-infiltrating lymphocytes (TIL) than other colorectal cancers. This feature is thought to reflect the accumulation of frameshift mutations in sequences that are repeated within gene coding regions, thereby leading to the synthesis of neoantigens recognized by CD8(+) T cells. However, there has yet to be a clear link established between CD8(+) TIL density and frameshift mutations in colorectal cancer. In this study, we examined this link in 103 MSI colorectal cancers from two independent cohorts where frameshift mutations in 19 genes were analyzed and CD3(+), CD8(+), and FOXP3(+) TIL densities were quantitated. We found that CD8(+) TIL density correlated positively with the total number of frameshift mutations. TIL densities increased when frameshift mutations were present within the ASTE1, HNF1A, or TCF7L2 genes, increasing even further when at least one of these frameshift mutations was present in all tumor cells. Through in vitro assays using engineered antigen-presenting cells, we were able to stimulate peripheral cytotoxic T cells obtained from colorectal cancer patients with peptides derived from frameshift mutations found in their tumors. Taken together, our results highlight the importance of a CD8(+) T cell immune response against MSI colorectal cancer-specific neoantigens, establishing a preclinical rationale to target them as a personalized cellular immunotherapy strategy, an especially appealing goal for patients with Lynch syndrome.
A Robust Method for TV Logo Tracking in Video Streams (2006)

Most broadcast stations rely on TV logos to claim video content ownership or visually distinguish the broadcast from the interrupting commercial block. Detecting and tracking a TV logo is of interest to TV commercial skipping applications and logo-based broadcasting surveillance (abnormal signal is accompanied by logo absence). Pixel-wise difference computing within predetermined logo regions cannot address semi-transparent TV logos well for the blending effects of a logo itself and inconstant background images. Edge-based template matching is weak for semi-transparent ones when incomplete edges appear. In this paper we present a more robust approach to detect and track TV logos in video streams on the basis of multispectral images gradient. Instead of single frame based detection, our approach makes use of the temporal correlation of multiple consecutive frames. Since it is difficult to manually delineate logos of irregular shape, an adaptive threshold is applied to the gradient image in subpixel space to extract the logo mask. TV logo tracking is finally carried out by matching the masked region with a known template. An extensive comparison experiment has shown our proposed algorithm outperforms traditional methods such as frame difference, single frame-based edge matching. Our experimental dataset comes from part of TRECVID2005 news corpus and several Chinese TV channels with challenging TV logos
Mechanical behavior of ultralong multiwalled carbon nanotube mats (2007)

Carbon nanotubes (CNTs) have been a subject of great interest partially due to their potential for exceptional material properties. Improvements in synthesis methods have facilitated the production of ultralong CNT mats, with lengths in the millimeter range. The increased length of these ultralong mats has, in return, opened the way to greater flexibility to probe their mechanical response. In this work, mats of dense, well-aligned, multiwalled carbon nanotubes were grown with a vapor-phase chemical vapor deposition technique using ferrocene and benzene as reactants, and subsequently tested in both tension and compression using two methods, in a thermomechanical analyzer and in situ inside a scanning electron microscope. In compression, measured stiffness was very low, due to buckling of the nanotubes. In tension, the nanotube mats behaved considerably stiffer; however, they were still more compliant than expected for nanotubes (∼1TPa). Analysis of both the growth method used and the nanotube mat fracture surface suggests that the mats grown in this method are not composed of continuous nanotubes and their strengths actually closely match those of woven nanotube yarns and ropes.
Standard CMOS active pixel image sensors for multimedia applications (2002)

The task of image acquisition is completely dominated by CCD-based sensors fabricated on specialized process lines. These devices provide an essentially passive means of detecting photons and moving image data across chip. We argue that line widths in standard CMOS have been reduced to the point where it is practical to locate transistors-and hence provide gain-within each detector of an imager fabricated in CMOS. In this paper we describe the image sensors we have been building in this technology. They use far less power, permit random access and can be integrated with arbitrary digital CMOS logic to create low cost single chip video cameras with advanced functionality. Ongoing work includes the development of a color filter array process and the fabrication of a 1024/spl times/1024 pixel sensor for multimedia video and document capture applications.
Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function (2009)

Many important cellular processes are regulated by small endogenous noncoding RNAs known as microRNAs (miRNAs). The precise molecular function of many miRNAs is unknown; different loss-of-function methods are required to gain insight into the biology of these small RNA molecules. Nucleic acid enzymes termed antagomirzymes are now shown to be valuable tools for the specific knockdown of miRNA in vitro and in vivo (see scheme).
Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure (2001)

We demonstrated an IVIG-induced change in the balance between inflammatory and anti-inflammatory cytokines that favored an anti-inflammatory net effect in CHF. This effect was significantly correlated with an improvement in LVEF, suggesting a potential for immunomodulating therapy in addition to optimal conventional cardiovascular treatment regimens in CHF patients.
DNA Variation in a Conifer, Cryptomeria japonica (Cupressaceae sensu lato) (2003)

We investigated the nucleotide variation of a conifer, Cryptomeria japonica, and the divergence between this species and its closest relative, Taxodium distichum, at seven nuclear loci (Acl5, Chi1, Ferr, GapC, HemA, Lcyb, and Pat). Samples of C. japonica were collected from three areas, Kantou-Toukai, Hokuriku, and Iwate. No apparent geographic differentiation was found among these samples. However, the frequency spectrum of the nucleotide polymorphism revealed excesses of intermediate-frequency variants, which suggests that the population was not panmictic and a constant size in the past. The average nucleotide diversity, pi, for silent sites was 0.00383. However, values of pi for silent sites vary among loci. Comparisons of polymorphism to divergence among loci (the HKA test) showed that the polymorphism at the Acl5 locus was significantly lower. We also observed a nearly significant excess of replacement polymorphisms at the Lcyb locus. These results suggested possibilities of natural selection acting at some of the loci. Intragenic recombination was detected only once at the Chi1 locus and was not detected at the other loci. The low level of population recombination rate, 4Nr, seemed to be due to both low level of recombination, r, and small population size, N.
Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1. (1983)

Monoclonal antibody BBM.1 (Brodsky, F.M., Bodmer, W. F., and Parham, P. (1979) Eur. J. Immunol. 9, 536-545) identifies an antigenic determinant of human beta 2-microglobulin (beta 2-M). The antibody binds free and HLA-A,B-associated beta 2-M with similar affinity, showing that the BBM.1 antigenic determinant does not involve residues of beta 2-M that interact with HLA-A,B heavy chains. Peptides (SWH.1-5) synthesized from residues 35-50 of the beta 2-M sequence specifically inhibit the binding of BBM.1 to cell surfaces. Their inhibitory activity is destroyed by trypsin treatment. The observations (i) that BBM.1 does not bind to beta 2-M of species other than man, gorilla, and chimpanzee and (ii) that arginine 45 is the only human-specific residue between positions 35 and 50 suggested that this residue might be part of the BBM.1 antigenic determinant. This hypothesis was confirmed by reversible modification of arginine residues with cyclohexanedione. Modification of arginines in native beta 2-M and of the single arginine, corresponding to position 45, in the peptide SWH.5 resulted in up to 95% loss of BBM.1 inhibitory activity. Reversal of the modification by treatment with hydroxylamine resulted in complete recovery of activity. Rabbit antibodies elicited by immunization of SWH.5 conjugated to bovine serum albumin showed no detectable reaction with native beta 2-M but did specifically react with human beta 2-M after sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electrophoresis onto nitrocellulose. These results thus identify a region around residue 45 of the beta 2-M polypeptide which is exposed to the environment and not involved in binding HLA-A,B heavy chain. Analysis of the beta 2-M sequence by calculating local hydrophilicity indices (Hopp, T. P., and Woods, K. R. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 3824-3828) agree with this region being a major antigenic determinant. Models of beta 2-M structure as an immunoglobulin domain show this region of polypeptide to be part of a loop between the two layers of beta-pleated sheet, also consistent with it being a major antigenic determinant. The position of the loop favors a model in which beta 2-M interacts with HLA across the four-stranded beta-pleated sheet like an immunoglobulin constant region domain.