gebhart/patrepeval huggingface dataset:
Meander-line polarizer (1973)

The meander-line polarizer consists of several printed-circuit sheets with etched-copper meander lines. The sheets are spaced about one-quarter wavelength apart. This communication explains the principle of operation of the polarizer, describes the design procedure, and gives dimensions and performance data of a typical polarizer. For example, an axial ratio of better than 1.5 dB has been obtained over <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</tex> band. The polarizer can be used for medium high-power densities. A theoretical analysis of dissipation loss and experimental results of high-power tests are presented.
Acute reaction to protamine. Its importance to surgeons. (1984)

Three open heart surgery patients developed noncardiogenic pulmonary edema after administration of protamine following cardiopulmonary bypass. A catastrophic series of events are characteristic of this reaction: 1) sudden onset; 2) severe bronchoconstriction with early extreme difficulty in ventilation; 3) hyperinflation of the lungs; 4) pulmonary hypertension with normal pulmonary wedge or left atrial pressures; 5) progression to fulminant noncardiogenic pulmonary edema; 6) significant mortality; and 7) ventilatory perfusion abnormalities in survivors. Review of the literature reveals three types of reactions to protamine injection of varying severity: 1) brief hypotension; 2) anaphylactoid generalized reaction; and 3) high protein noncardiogenic pulmonary edema with cardiopulmonary collapse. The severity of the reaction had no relation to the dose of protamine. Previous protamine exposure was documented in 14 of 35 cases. Awareness of this reaction is essential for prompt treatment if fulminant pulmonary edema occurs. Administration of epinephrine, steroids, vasopressors, and potassium replacement may be required. Needless use of protamine sulfate should be discouraged.
Potential cholinergic and anticholinergic compounds: Synthesis of 2,8-substituted 2,8-diazaspiro[4,5]decane-1,3-diones (1990)

Heating the ammonium salt of (4-carboxy-1-methyl-4-piperidinyl)acetic acid ( XII ) gave 8-methyl-2,8-diazaspiro[4,5]decane-1,3-dione ( II ) which was N-alkylated with 2-bromoethanol and 4-bromobutanol to give the alcohols III and V . Compound III was transformed to the chloro compound VI which was reacted with the sodium salt of hexahydrobenzilic acid to give the ester VII . Compound V was transformed to the 4-toluenesulfonic ester VIII which reacted with 1-(2-pyrimidinyl)piperazine and gave IX . 2-(2-Propyl)-2,8-diazaspiro[4,5]decane-1,3-dione ( XVIII ) was similarly transformed via XIX to XX which reacted with the sodium salts of diphenylacetic, benzilic, hexahydrobenzilic, and (2-oxo-1-pyrrolidinyl)acetic acid to give the esters XXI-XXIV . The esters VII and XXI-XXIV were transformed to the methiodides. The compounds prepared were tested in the lines of activity of the analogous "RS-86" ( I ) but proved inactive.
Ribavirin, tiazofurin, and selenazofurin: mononucleotides and nicotinamide adenine dinucleotide analogs. Synthesis, structure, and interactions with IMP dehydrogenase (1985)

A series of dinucleotides, analogous to nicotinamide adenine dinucleotide but containing the five-membered base nucleosides tiazofurin (1a), selenazofurin (1b), ribavirin (2), and AICAR (3) in place of nicotinamide ribonucleoside, were prepared in greater than 50% yield by reacting the corresponding nucleotide imidazolidates (6a-d) with adenosine 5'-monophosphate (AMP). The symmetric dinucleotides of tiazofurin (TTD, 8e) and selenazofurin (SSD, 8f) were also prepared by a similar methodology. These dinucleotides were characterized by 1H NMR and fast atom bombardment MS and were evaluated for their inhibitory potency against a partially purified preparation of tumoral inosine monophosphate dehydrogenase (IMPD) from P388 cells. The order of potency found was SAD (8b) greater than TAD (8a) much greater than SSD (8f) congruent to TTD (8e) congruent to RAD (8c) much much greater than ZAD (8d). On kinetic analysis none of the dinucleotides produced competitive inhibition of IMPD with NAD as a variable substrate. In addition to their superior IMPD inhibitory activity, SAD and TAD appear to be the only dinucleotides, besides NAD, that are formed naturally by the NAD pyrophosphorylase from P388 lymphoblasts.
Vaccination with a Recombinant Vesicular Stomatitis Virus Expressing an Influenza Virus Hemagglutinin Provides Complete Protection from Influenza Virus Challenge (1998)

Since the development of a system for generating vesicular stomatitis virus (VSV) from plasmid DNAs, our laboratory has reported the expression of several different glycoproteins from recombinant VSVs. In one of these studies, high-level expression of an influenza virus hemagglutinin (HA) from a recombinant VSV-HA and efficient incorporation of the HA protein into the virions was reported (E. Kretzschmar, L. Buonocore, M. J. Schnell, and J. K. Rose, J. Virol. 71:5982-5989, 1997). We report here that VSV-HA is an effective intranasal vaccine vector that raises high levels of neutralizing antibody to influenza virus and completely protects mice from bronchial pneumonia caused by challenge with a lethal dose of influenza A virus. Additionally, these recombinant VSVs are less pathogenic than wild-type VSV (serotype Indiana). This vector-associated pathogenicity was subsequently eliminated through introduction of specific attenuating deletions. These live attenuated recombinant VSVs have great potential as vaccine vectors.
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells (1989)

PADGEM protein (PADGEM), also known as GMP140, is a platelet alpha-granule membrane protein that is translocated to the external membrane after platelet activation. Although the biosynthesis of this protein was originally thought to be confined to megakaryocytes, the synthesis of PADGEM in endothelial cells was recently demonstrated (McEver et al: Blood 70:1974a, 1987). We now describe the subcellular localization of this protein in endothelial cells. Immunofluorescence staining of permeabilized human umbilical vein endothelial cells with KC4, a well characterized monoclonal antibody to PADGEM, showed positively stained elongated structures similar in distribution and shape to Weibel-Palade bodies. Their identity as Weibel-Palade bodies was confirmed by double label immunofluorescence using KC4 and a polyclonal antiserum to von Willebrand factor (vWf), a protein known to be specifically stored in these organelles. All Weibel-Palade bodies were found to contain PADGEM. In contrast to strong perinuclear staining produced with anti-vWf antibodies, no significant perinuclear staining was obtained with KC4, indicating that relatively little PADGEM is present in the endoplasmic reticulum and in the Golgi apparatus. In endothelial cells treated with secretagogues that stimulate vWf release the elongated structures positive for PADGEM disappeared, further identifying these structures as Weibel-Palade bodies. This observation extends the parallels between Weibel-Palade bodies and alpha-granules and suggests a possible functional association between vWf and PADGEM.
Pharmacological remodelling of human atrial k+ currents by chronic beta-blockade (2006)

The chronic treatment of patients with a beta-blocker is associated with prolongation of the atrial action potential duration (APD), potentially contributing to its ability to prevent atrial fibrillation (AF). This may involve pharmacological remodelling of atrial K+ currents which affect APD. This project aimed to test the hypothesis that various characteristics of human atrial K+ currents, including voltage, time and rate dependency, differ between patients treated and not treated with a beta-blocker.
Part-of-speech tagging with minimal lexicalization (2004)

We use a Dynamic Bayesian Network to represent compactly a variety of sublexical and contextual features relevant to Part-of-Speech (PoS) tagging. The outcome is a flexible tagger (LegoTag) with state-of-the-art performance (3.6% error on a benchmark corpus). We explore the effect of eliminating redundancy and radically reducing the size of feature vocabularies. We find that a small but linguistically motivated set of suffixes results in improved cross-corpora generalization. We also show that a minimal lexicon limited to function words is sufficient to ensure reasonable performance.
Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand (2000)

4-1BB is a member of the TNF receptor family predominantly expressed on activated T cells, and binds an inducible ligand found on B cells, macrophages and dendritic cells. Whereas ligation of 4-1BB has been shown to enhance response of purified CD8 T cells to mitogens, and to augment NK activity and generation of cytotoxic T lymphocytes in vivo, there are little direct data on 4-1BB action during CD4 responses. Using pigeon cytochrome c-presenting fibroblast antigen-presenting cells transfected with 4-1BB ligand (4-1BBL), we show that engaging 4-1BB on naive CD4 cells promotes proliferation, cell cycle progression and IL-2 secretion, and suppresses cell death, all to a similar extent as B7-1 engagement of CD28. In addition, 4-1BBL synergizes with B7 and ICAM to enhance naive CD4 proliferation when antigen is limiting. 4-1BBL alone, and to a greater extent with B7, also augmented IL-2 secretion resting antigen-experienced CD4 cells, as typified by T helper clones, whereas short-term effector cells showed similar levels of proliferation and cytokine secretion regardless of whether 4-1BB was engaged. A major role in augmenting IFN-gamma, IL-4 or IL-5 was not demonstrated. Blocking studies with activated B cells presenting antigen showed that 4-1BB participates in promoting IL-2 production by resting CD4 cells, confirming that 4-1BBL can play a role in antigen-specific CD4 T cell responses.
Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo (2004)

Notch transmembrane receptors are known to play a critical role in cell-fate decisions, with Notch1 shown to enhance self-renewal of hematopoietic stem cells and cause T-cell leukemia. Four Notch receptors exist, and the extent of redundancy and overlap in their function is unknown. Notch4 is structurally distinct from Notch1 through Notch3 and has not been extensively studied in hematopoiesis. By polymerase chain reaction (PCR) we find Notch4 transcript expression in human marrow cells and in both CD34(+) and CD34(-) populations. When constitutively active Notch1 or Notch4 was overexpressed in normal human marrow or cord cells, we found reduced colony-forming and short-term proliferative ability while the primitive progenitor content of myeloid long-term cultures was significantly increased. Notch4-intracellular domain (Notch4-IC)-transduced cord cells transplanted into beta(2)-microglobulin(-/-) nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice resulted in significantly higher levels of engraftment of both green fluorescent protein-positive (GFP(+)) and GFP(-) populations as compared with controls. GFP(+) cells in bone marrow and spleen of animals that had received transplants gave rise to an immature CD4(+)CD8(+) T-cell population, whereas B-cell development was blocked. These results indicate that activation of Notch4 results in enhanced stem cell activity, reduced differentiation, and altered lymphoid development, suggesting it may influence both stem cells and the fate of the common lymphoid progenitor.
CPP GMR Through Nanowires (2012)

All-metal current perpendicular to the plane (CPP) giant magnetoresistance (GMR) layers have been made within insulating matrices by direct growth to avoid sidewall damage that is caused by lithographical patterning in current vacuum-deposited devices. These insulating matrices can be made to have nanostructures with multiscale order to allow photolithographical alignment of contacts to 10-500 nm devices. This alignment was demonstrated with 100-200 nm diameter structures to prove feasibility. Next, trilayers of [Co(15 nm)/Cu(5 nm)/Co(10 nm)] with 10 nm diameters were made by electrochemical deposition with 30 Ω resistance and 19% magnetoresistance. These parameters are desirable for read head sensors, especially because the nanowires described here have 1:1 aspect ratios, 10× smaller areas, and 100× lower resistances than conventional read sensors based on lithographically-produced magnetic tunnel junctions. Finally, the potential application of closely spaced arrays of CPP GMR sensors for enabling one-pass two dimensional recording as well as a new technique called cross recording will be discussed.
Brain hyperthermia: I. interstitial microwave antenna array techniques—the Dartmouth experience (1994)

Patient data analysis showed that the array of four dipole antennas spaced 2.0 cm apart were capable of heating a volume of 5.9 cm (along the central array axis) x 2.8 cm x 2.8 cm.
Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders:  Structure−Activity Relationship (2004)

Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory effects on disease development in the acute experimental autoimmune encephalomyelitis model and selected compounds in the beagle dog for induction of proinflammatory reaction. Structure-activity relationships are discussed. Compound 8c, laquinimod, showed improved potency and superior toxicological profile compared to the lead compound roquinimex (1b, Linomide) and was selected for clinical studies (currently in phase II).
Automatic History Matching of Geologic Facies (2003)

Abstract The truncated pluri-Gaussian method for modeling geologic facies is appealing not only for the wide variety of textures and shapes that can be generated, but also because of the internal consistency of the stochastic model. This method has not, however, been widely applied in simulating distributions of reservoir properties facies or in automatic history matching. One reason seems to be that it is fairly difficult to estimate the parameters of the stochastic model that could be used to generate geological facies maps with the desired properties. The second is that because "facies type" is a discrete variable, it is not straightforward to apply the efficient gradient-based minimization method to generate reservoir facies models that honor production data. Non-gradient methods, however, are too slow for large field-scale problems. In this paper, the non-differentiable history-matching problem was replaced with a differentiable problem so that an automatic history matching technique could be applied to the problem of conditional simulation of facies boundaries generated from the truncated pluri-Gaussian method. The resulting realizations are consistent both with the geostatistical model of the observed facies and the historic production. Application of the method requires efficient computation of the gradient of the objective function with respect to model variables. We present an example five-spot water injection problem with more than 73,000 model variables conditioned to pressure data at wells. The gradient was computed using the adjoint simulator method, and the minimization routine used a quasi-Newton method. The data mismatch decreased more than 90% in the first two iterations.
ChemInform Abstract: SYNTHESES OF PASHANONE AND ITS ISOMERS AND THEIR DERIVATIVES (1974)

Pashanon (IIa) sowie die Isomeren (IIb), (VI) und (IX) sind durch Behandlung der . Flavanone (Ia), (Ib) (bekannte Verbindungen), (Vb) bzw. (VIIIb) mit methanolischer KOH zugänglich.
Immunocytochemical analysis of AlgP (Hp1), a histonelike element participating in control of mucoidy in Pseudomonas aeruginosa (1992)

AlgP, a protein with an unusual carboxy-terminal domain resembling the tails of eukaryotic H1 histones, was detected in whole-cell extracts and within the cells of Pseudomonas aeruginosa by using immunoblotting and immunoelectron microscopy analyses. One known function of AlgP is its participation in the transcriptional activation of the algD gene. This is a pivotal step in the establishment of mucoidy in P. aeruginosa; mucoidy is a critical virulence factor expressed during respiratory infections in patients with cystic fibrosis. Polyclonal and monoclonal antibodies were raised against a synthetic 50-mer peptide containing two sets of six tandem repeats of the motif Lys-Pro-Ala-Ala (and its single-amino-acid substitution variants), based on the sequence of the algP gene from the standard genetic strain PAO. Western immunoblots with these antibodies and total protein extracts from P. aeruginosa revealed two polypeptides that reacted with the antibodies in all of the P. aeruginosa strains tested. The detected polypeptides displayed strain-dependent variability in their electrophoretic mobility, in accordance with the previously noted variability of the algP repeats at the DNA level. In strain PAO, the recognized polypeptides had apparent masses of 46.4 and 41.6 kDa. Immunoelectron microscopy revealed that AlgP is an intracellular protein with a wide distribution suggestive of its more general role. To indicate that fact, AlgP is given here an alternative name, Hp1. Since AlgP (Hp1) is a eubacterial histonelike element displaying sequence and domanial similarity with eukaryotic H1 histones, these findings may have implications on the understanding of the organization of the prokaryotic nucleoid and its role in the control of gene expression and bacterial virulence.
Synthesis of superconducting YBa2Cu3O7−δ thin films on nickel-based superalloy using in situ pulsed laser deposition (1990)

Good quality superconducting YBa2Cu3O7−δ thin films have been grown on nickel-based superalloy, viz., Hastelloy with yttria-stabilized zirconia buffer layers employing a single chamber in situ pulsed laser deposition process. YBa2Cu3O7−δ films were found to be textured with c axis perpendicular to the substrate. A plot of normalized resistance against temperature exhibited a smooth metallic behavior followed by an onset superconducting transition at 92 K with the zero resistance temperature (Tc0) of 86 K. Critical current density for these films at 77 K was ∼7000 A cm−2 and critical current (Ic) was observed to be proportional to (1 − T/Tc0)1.4.
Cladding mode effect in superstructure fiber Bragg gratings and its applications in simultaneous strain and temperature measurement (2002)

Periodically modulated exposure makes the superstructure fiber Bragg grating functions as a long-period grating and so introduce broad-band loss peaks in the transmission spectrum. This characteristic has applications in simultaneous measurement for temperature and strain.
Imaging Lipid Metabolism in Live Caenorhabditis elegans Using Fingerprint Vibrations (2014)

Quantitation of lipid storage, unsaturation, and oxidation in live C. elegans has been a long-standing obstacle. The combination of hyperspectral stimulated Raman scattering imaging and multivariate analysis in the fingerprint vibration region represents a platform that allows the quantitative mapping of fat distribution, degree of fat unsaturation, lipid oxidation, and cholesterol storage in vivo in the whole worm. Our results reveal for the first time that lysosome-related organelles in intestinal cells are sites for storage of cholesterol in C. elegans.
Spontaneous regression of cancer and the importance of finding its cause. (1976)

A few years ago Everson and I assembled all the examples of spontaneous regression in the world medical literature from 1900 to 1960 and added numerous cases from expriences of our friends. Our figure was 176. We excluded squamous cell carcinoma of the skin, leukemia, Hodgkin's disease, and a large number of cases that did not fulfill the prerequisites of confirmed diagnosis and no significant treatment. The four most common examples of regression were carcinoma of the kidney (31), neuroblastoma (29), malignant melanoma (19), and choriocarcinoma (19); these constituted more than half the group. We did not require that the regression be permanent because it appeared that the explanation of temporary regression would be just as important as the cause of permanent regression. There was no proven specific cause of the regression, but the following mechanisms had a possible relationship: immunologic action, elimination of carcinogens, trauma (altering the antigen-antibody relationship), hormones, irradiation, infection and/or fever, and drugs or chemicals. The most applicable of these is elimination of the carcinogen. Immunologic reactions seem to offer the best explanation, and the potential of humoral immunity is more impressive than that of cellular immunity.
Fundamental studies of biodegradable hydrogels as cartilage replacement materials. (1999)

Through intelligent control of monomer chemistry and gelling techniques, biodegradable hydrogels with a range of mechanical strengths and degradation timescales have been constructed. A diacrylated, copoly(ethylene glycol-b-dl-lactic acid) (PEG-b-PLA) macromer was used to produce synthetic networks with equilibrium water contents (EWC) above 70% and initial compressive moduli values exceeding 1 MPa, demonstrating its viability as a cartilage replacement material. Experiments have shown that the mechanical strengths, EWCs, and useful lifetimes of these water-swellable networks are coupled to their copolymer chemistry as well as their processing conditions. A systematic study utilizing photopolymerized gels has been undertaken to elucidate the controlling factors behind the bulk-degradation process, as well as monitor changes in network structure with degradation. A statistical model will be used in conjunction with the experimental data to explain the exponential modulus decay and complex mass loss behavior observed during degradation for these hydrogels.
Biochemical and Physical Properties of a Solvent-Detergent-TreatedFibrin Glue (1990)

A fibrin glue preparation has been obtained from pooled human plasma using a procedure which includes a solvent-detergent (SD) treatment to inactivate lipid-enveloped viruses. The SD treatment inactivated ≥5.5 log(10) of HIV in less than 45 min, and ≥5 log(10) and ≥6.5 log(10) of VSV and Sindbis virus, respectively, in less than 2 h. The product was found to contain high quantities of fibrinogen (116±2.49 g/l; n = 12), factor XIII (35±2.88 U/ml) and von Willebrand factor (23±1.9 U/ml ristocetin cofactor activity), and relatively low levels of fibronectin (5.9±0.51 g/l). Plasminogen, the precursor of plasmin, which may play a negative role by decreasing the resistance of the fibrin clot, was at only 0.03 g/l. Cellulose acetate electrophoresis showed 95% gamma-proteins and 5% alpha-2-beta proteins. Sodium dodecyl sulfate polyacrylamide gel electrophoresis under reducing conditions detected three main protein bands with apparent molecular weights of 65, 56 and 47 kilodaltons, probably corresponding to the alpha, beta, and gamma fibrinogen subunits. Other characteristics of the product included (1) high clottability of fibrinogen (over 85%); (2) absence of low molecular weight fibrin degradation products; (3) rapid solubilization at room temperature (less than 10 min); (4) high tensile strength (202±27 g/cm^2 after 2 h of application), and (5) high elasticity of the fibrin clot. In addition, scanning electron microscopy revealed a highly organized structure showing tridimensional arrangement of the fibrin fibers. SD treated fibrin glue should efficiently replace autologous fibrinogen or cryoprecipitate preparations for surgical application.