gebhart/patrepeval huggingface dataset:
Screening for Obstructive Sleep Apnea in Patients Presenting for Snoring Surgery (1996)

Excessive mortality is associated with obstructive sleep apnea (OSA). Therefore it is important to diagnose OSA in patients presenting for snoring surgery. A prospective study was performed to develop screening models to detect OSA compared with universal polysomnography for sensitivity and cost. Multivariate analysis of 150 consecutive patients was based on clinical data, questionnaire data, and polysomnography. Two screening models obtained 100% sensitivity and reduced the need for polysomnograms. Cost savings of screening based on clinical data was projected to be $35 to $80 per patient using reported prevalence rates of OSA among snorers. A screening model for OSA using clinical data alone is more cost-effective than one that combines these data with pulse oximetry data, but savings over universal polysomnography were modest.
Transforming Growth Factor β1 Induces Apoptosis through Cleavage of BAD in a Smad3-Dependent Mechanism in FaO Hepatoma Cells (2002)

Transforming growth factor beta (TGF-beta) induces apoptosis in a variety of cells. We have previously shown that TGF-beta 1 rapidly induces apoptosis in the FaO rat hepatoma cell line. We have now studied the effect of TGF-beta 1 on the expression of different members of the Bcl-2 family in these cells. We observed no detectable changes in the steady-state levels of Bcl-2, Bcl-X(L), and Bax. However, TGF-beta 1 induced caspase-dependent cleavage of BAD at its N terminus to generate a 15-kDa truncated protein. Overexpression of the 15-kDa truncated BAD protein enhanced TGF-beta 1-induced apoptosis, whereas a mutant BAD resistant to caspase 3 cleavage blocked TGF-beta 1-induced apoptosis. Overexpression of Smad3 dramatically enhanced TGF-beta 1-induced cleavage of BAD and apoptosis, whereas antisense Smad3 blocked TGF-beta 1-induced apoptosis and BAD cleavage. These results suggest that TGF-beta 1 induces apoptosis through the cleavage of BAD in a Smad3-dependent mechanism.
Total synthesis of an enzyme with ribonuclease A activity (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of an enzyme with ribonuclease A activityBernd Gutte and Robert B. MerrifieldCite this: J. Am. Chem. Soc. 1969, 91, 2, 501–502Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://doi.org/10.1021/ja01030a050RIGHTS & PERMISSIONSArticle Views1246Altmetric-Citations235LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (291 KB) Get e-Alertsclose Get e-Alerts
Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications (2012)

Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. The inclusion of a second biopolymer strengthens the stability of resultant hydrogels and enriches its functionalities by bringing in new functional groups or optimizing the micro-environmental conditions for certain biological and biochemical processes. This article presents approaches that have been used by our groups to synthesize biopolymer hybrid hydrogels for effective uses for immunotherapy, tissue regeneration, food and functional food applications. The research has achieved some challenging results, such as stabilizing physical structure, increasing mucoadhesiveness, and the creation of an artificial extracellular matrix to aid in guiding tissue differentiation.
Updated national birth prevalence estimates for selected birth defects in the United States, 2004–2006 (2010)

Accurate and timely national estimates of the prevalence of birth defects are needed for monitoring trends, assessing prevention efforts, determining service planning, and understanding the burden of disease due to birth defects in the United States.
Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates (2017)

Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather than neurons. Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic support and demyelination, leading to neurodegeneration. To date, only a murine model using one of three promoters exist to study this disease. We sought to develop novel rat and nonhuman primate (NHP) models of MSA by overexpressing α-syn in oligodendroglia using a novel oligotrophic adeno-associated virus (AAV) vector, Olig001. To establish tropism, rats received intrastriatal injections of Olig001 expressing GFP. Histological analysis showed widespread expression of GFP throughout the striatum and corpus callosum with >95% of GFP+ cells co-localizing with oligodendroglia and little to no expression in neurons or astrocytes. We next tested the efficacy of this vector in rhesus macaques with intrastriatal injections of Olig001 expressing GFP. As in rats, we observed a large number of GFP+ cells in gray matter and white matter tracts of the striatum and the corpus callosum, with 90-94% of GFP+ cells co-localizing with an oligodendroglial marker. To evaluate the potential of our vector to elicit MSA-like pathology in NHPs, we injected rhesus macaques intrastriatally with Olig001 expressing the α-syn transgene. Histological analysis 3-months after injection demonstrated widespread α-syn expression throughout the striatum as determined by LB509 and phosphorylated serine-129 α-syn immunoreactivity, all of which displayed as tropism similar to that seen with GFP. As in MSA, Olig001-α-syn GCIs in our model were resistant to proteinase K digestion and caused microglial activation. Critically, demyelination was observed in the white matter tracts of the corpus callosum and striatum of Olig001-α-syn but not Olig001-GFP injected animals, similar to the human disease. These data support the concept that this vector can provide novel rodent and nonhuman primate models of MSA.
Screened poisson surface reconstruction (2013)

Poisson surface reconstruction creates watertight surfaces from oriented point sets. In this work we extend the technique to explicitly incorporate the points as interpolation constraints. The extension can be interpreted as a generalization of the underlying mathematical framework to a screened Poisson equation. In contrast to other image and geometry processing techniques, the screening term is defined over a sparse set of points rather than over the full domain. We show that these sparse constraints can nonetheless be integrated efficiently. Because the modified linear system retains the same finite-element discretization, the sparsity structure is unchanged, and the system can still be solved using a multigrid approach. Moreover we present several algorithmic improvements that together reduce the time complexity of the solver to linear in the number of points, thereby enabling faster, higher-quality surface reconstructions.
A Prospective Follow-Up Study of Low Back Pain in the Community (2000)

Results showed that low back pain is a mutable problem with acute episodes blending into longer periods resulting in more disability as time progresses. A wide range of demographic, pain, consultation, and treatment factors were not predictive of low back pain recovery.
Promoter of the adenovirus polypeptide IX gene: similarity to E1B and inactivation by substitution of the simian virus 40 TATA element (1991)

The promoter of the adenovirus polypeptide IX (pIX) gene consists of an SP1 binding site and a TATA box and is remarkably similar to the promoter of the E1B gene in which it is nested. Plasmid constructs containing the pIX gene with deletions in the SP1 or TATA sites were defective in pIX mRNA production in transient expression assays. These results were confirmed with analogous virus constructs. An oligonucleotide containing sequences within the pIX promoter region spanning the SP1 and TATA sites but not including the sequences downstream of the TATA box is sufficient to direct mRNA synthesis at +90 nucleotides within the pIX gene. While the simian virus 40 (SV40) early promoter is capable of directing pIX mRNA synthesis from the SV40 cap sites, substitution of the pIX TATA box with the SV40 TATA box results in barely detectable levels of pIX mRNA. These results will be discussed with respect to exchangeability of promoter elements and the possible role of the viral E1B 21-kDa protein in potentiating or stabilizing transcription factor TFIID binding to the pIX TATA element.
Solving the Modeling Problems of Object-Oriented Languages By Composing Multiple Aspects Using Composition Filters (1998)

Building software from reusable components is considered important in reducing development costs. Object-oriented languages such as C++, Smalltalk and Java, however, are not capable of expressing certain aspects of applications in a reusable way. Software engineers may experience difficulties in composing and reusing applications from components, for example if components implement code for multiple views, dynamic inheritance and synchronization [6]. If these aspects have to be programmed, then object -oriented languages may require a considerable amount of redefinition although this may not be intuitively necessary. Several researchers termed these problems as inheritance anomalies, cross-cutting, etc. [12][8][10][11]. Aspectoriented programming aims at addressing these problems by specifying and composing the aspects of a program in a systematic way [10]. Composition-Filters is an aspect-oriented programming technique where different aspects are expressed in Filters as declarative an...
Nitric oxide is an effector molecule in inhibition of tumor cell growth by rIFN-γ-activated rat neutrophils (1997)

This study was designed to determine the effector molecule responsible for the tumor-inhibitory activity of rat neutrophils treated with rat recombinant interferon gamma (rIFN-gamma) in vitro. The results show that nitric oxide (NO) production by neutrophils is dependent on rIFN-gamma concentration, and that neutrophil-mediated tumor cytostasis is in turn dependent on the amount of NO. NO production and tumor cytostasis by rIFN-gamma-activated neutrophils were inhibited completely by N(G) monomethyl-L-arginine (NGMMA), a specific competitive NO production inhibitor. Tumor cytostasis was also inhibited by oxyhemoglobin (HbO(2)), an NO scavenger. An extracellular oxygen radical scavenger, superoxide dismutase (SOD), was found to increase tumor cell inhibition by rIFN-gamma-activated neutrophils by a factor of 4. This SOD-enhanced cytostasis was not even inhibited by catalase. Tumor cytostasis was slightly increased by a hydroxyl radical-(.OH) scavenger, dimethylthiourea (DMTU), which did not affect NO production by rIFN-gamma-activated neutrophils. Our findings suggest that tumor cytostasis of neutrophils activated by rIFN-gamma is mediated by L-arginine-derived nitrogen oxidation products, and that O(2)- produced by these neutrophils reduces NO-mediated tumor cytostasis at low NO concentrations.
Combining case-based reasoning and task-specific architectures (1994)

Case-based reasoning recognizes the power of individual solutions, while task-specific architectures take advantage of commonalities among groups of solutions. The key to combining the two lies in solving the riddle of case-based reasoning: how can uninterpreted cases be indexed for future use?.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors (1996)

We have purified two forms of phosphoinositide 3-kinase (PI3K) that are activated by heterotrimeric G-protein beta gamma-subunits. These novel isoforms of PI3K are structurally distinct to those forms of PI3K which have already been cloned. They are both heterodimers made up of a p120 and a p101 and a p117 and a p101 protein. The p101 species in both heterodimers are identical and show no substantial homology with any other proteins or DNA sequences. The p117 and p120 are highly related. The p101 and p120 species have been cloned from a pig neutrophil mRNA library. The p120 has similarities with other known PI3K catalytic subunits. They may be responsible for conferring cells with the capacity to produce phosphatidylinositol (3,4,5)-trisphosphate in response to activation of G-protein-coupled receptors. Activation of both the monomeric G-protein rac and PI3K(s) have been implicated in receptor-stimulated membrane-ruffling. We have observed that agonist-stimulated guanine nucleotide exchange on rac can be inhibited by a variety of PI3K inhibitors. This suggests PI3K may lie upstream of rac in receptor-driven pathways regulating cell movement.
Management of severe sepsis: advances, challenges,&nbsp;and current status (2015)

The complexity of treating severe sepsis and septic shock has been elucidated in myriad studies, particularly in the past 10 years. The development of clinical guidelines, insight into the effect of bundle elements, and results of clinical trials have brought to light further opportunities and questions in the approach to pharmaceutical interventions for the global challenge to save lives and reduce healthcare costs. Therapeutic interventions including fluid resuscitation, hemodynamic monitoring, glycemic control, corticosteroids, and antimicrobial therapy and stewardship inform outcomes. Research on biomarkers, use of mesenchymal stem cells, blood purification, immunoglobulins, and antioxidative treatments apropos the immune response may soon yield viable therapies.
A Robust Predictive Current Control for Three-Phase Grid-Connected Inverters (2009)

This paper presents a new predictive control algorithm for grid-connected current-controlled inverters. The control combines a two-sample deadbeat control law with a Luenberger observer to estimate the future value of the grid currents. The resulting control offers robustness against the computational delay inherent in the digital implementation and considerably enhances the gain and phase margins of the previous predictive controls while maintaining the high-speed response typical of the deadbeat controllers.
Epidemiology of hip fractures in Göteborg, Sweden, 1940-1983. (1984)

A dramatic progressive increase in the incidence of cervical and trochanteric fractures of the proximal end of the femur was observed in Göteborg from 1940 to 1983. From 1965 through 1983, the fracture rate increased by 109%. Only 20% of the increase can be explained by the age factors in the population. With the present trend, which appeared to be validated by the observed fracture rate from 1981 to 1983, the fracture incidence would double in 16 years in men and in 30 years in women.
Image Inpainting by Patch Propagation Using Patch Sparsity (2010)

This paper introduces a novel examplar-based inpainting algorithm through investigating the sparsity of natural image patches. Two novel concepts of sparsity at the patch level are proposed for modeling the patch priority and patch representation, which are two crucial steps for patch propagation in the examplar-based inpainting approach. First, patch structure sparsity is designed to measure the confidence of a patch located at the image structure (e.g., the edge or corner) by the sparseness of its nonzero similarities to the neighboring patches. The patch with larger structure sparsity will be assigned higher priority for further inpainting. Second, it is assumed that the patch to be filled can be represented by the sparse linear combination of candidate patches under the local patch consistency constraint in a framework of sparse representation. Compared with the traditional examplar-based inpainting approach, structure sparsity enables better discrimination of structure and texture, and the patch sparse representation forces the newly inpainted regions to be sharp and consistent with the surrounding textures. Experiments on synthetic and natural images show the advantages of the proposed approach.
Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. (1986)

Antibodies directed against thyroxine-binding globulin (TBG) have been used to screen a human liver lambda gt11 expression library. A 1.46-kilobase clone was identified which encodes nearly the complete amino acid sequence, beginning at amino acid 17 of the mature protein. To complete the protein sequence, the cDNA clone was used to identify a genomic clone coding for TBG in a human X chromosome library. The overlapping recombinant clones contained an open reading frame coding for 415 amino acids followed by a polyadenylylation signal (AATAAA) located 275 nucleotides from a TAG termination codon. Beginning at residue 21, the deduced amino acid sequence agrees closely with the known NH2-terminal sequence of the mature peptide. The preceding 20 amino acid residues are hydrophobic in character and presumably represent a leader sequence. Four glycosylation sites were identified, corresponding to the number determined for the purified protein. DNA blot hybridization revealed a single-copy gene, which by chromosomal analysis was found to be located on the long arm of the X chromosome. Unexpectedly, the nucleotide sequence of TBG is closely homologous to those encoding the plasma serine antiproteases alpha 1-antichymotrypsin and alpha 1-antitrypsin. However, there is little overall homology between TBG and transthyretin (prealbumin), the other major thyroxine-binding protein of human plasma.
Content of α‐tocopherol in blood serum of humanpapillomavirus‐infectedwomen with cervical dysplasias (1997)

The studies were carried out in a group of 228 female patients with normal cytological smear and 324 patients with cervical intraepithelial neoplasia. The applied method of identification, i.e., the human Papillomavirus (HPV) digene hybrid capture system, made it possible to select a control group consisting of 168 HPV-negative patients with normal Pap smear, as well as a group of 228 HPV-positive patients with cervical intraepithelial neoplasia. The high-performance liquid chromatography method was employed to evaluate the level of alpha-tocopherol in the blood serum of the patients who were examined. A statistically significantly lower level of alpha-tocopherol was observed in the blood serum of HPV-positive patients with cervical intraepithelial neoplasia. The risk of dysplasia was four times higher for an alpha-tocopherol level < 7.95 mumol/l.
Semicontinuous emulsion polymerization of methyl methacrylate, ethyl acrylate, and methacrylic acid (1996)

By a semicontinuous emulsion polymerization method with a variable monomer feed rate, a terpolymeric latex of methyl methacrylate and ethyl acrylate functionalized with methacrylic acid was synthesized. Conversion and reactor temperature vs. time were followed during the reaction. Characterization of the latex system was performed by particle-size measurements, scanning electron microscopy, infrared spectroscopy, viscometric molecular weight, glass transition temperature measurement, and rheological behavior. © 1996 John Wiley & Sons, Inc.
Combinatorial approaches to harmacophoric heterocycles: A solid-phase synthesis of 3,1-benzoxazine-4-ones (1998)

An efficient solid-phase synthesis of 3,1-benzoxazine-4-ones is described. Immobilized amino acid based functionalized urea derivatives 2 undergo a high yielding heterocyclization under mild conditions in presence of coupling reagents (DIC, TsCl/Py, or Ac2O) to afford 3,1-benzoxazine-4-ones 6. The method offers broad scope for structural and chemical diversity, and is amenable for combinatorial synthesis of 3,1-benzoxazine-4-ones libraries with potential for discovery of novel serine protease inhibitors. Copyright 1998 John Wiley & Sons, Inc.
Cell Biology Of Von Willebrand Factor (1990)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
Structural, magnetic, and transport properties of RxBa1-xTiO3-.delta. solid solutions, where R = La, Nd, Gd, Er, and Y: rare-earth-dependent metal-to-semiconductor transitions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural, magnetic, and transport properties of RxBa1-xTiO3-.delta. solid solutions, where R = La, Nd, Gd, Er, and Y: rare-earth-dependent metal-to-semiconductor transitionsCahit Eylem, Gotthard Saghi-Szabo, Bai Hao Chen, Bryan Eichhorn, Jian Liang Peng, Richard Greene, Lourdes Salamanca-Riba, and Sahn NahmCite this: Chem. Mater. 1992, 4, 5, 1038–1046Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/cm00023a022https://doi.org/10.1021/cm00023a022research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts