gebhart/patrepeval huggingface dataset:
Some Derivatives of 7-Methoxy- and 10-Methoxybenzo (f) quinoline (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Derivatives of 7-Methoxy- and 10-Methoxybenzo (f) quinolineAlbert C. Mueller and Cliff S. HamiltonCite this: J. Am. Chem. Soc. 1944, 66, 6, 860–862Publication Date (Print):June 1, 1944Publication History Published online1 May 2002Published inissue 1 June 1944https://pubs.acs.org/doi/10.1021/ja01234a003https://doi.org/10.1021/ja01234a003research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Soft output demodulation on frequency-selective Rayleigh fading channels using AR channel models (2002)

This paper presents a systematic study of high performance soft output demodulation for frequency-selective Rayleigh fading using an AR channel model. For channel taps modeled as AR processes, the optimum symbol-by-symbol demodulator is derived. Additionally a demodulator with an extended Kalman filter (KF) is proposed that jointly identifies and tracks the channel and the unknown parameters in AR channel models. A simulation study shows the proposed algorithms offer significant advantages in performance or complexity compared to previously proposed algorithms.
Acylation of indoles by Duff reaction and Vilsmeier-Haack formylation and conformation of N-formylindoles (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcylation of indoles by Duff reaction and Vilsmeier-Haack formylation and conformation of N-formylindolesA. Chatterjee and K. M. BiswasCite this: J. Org. Chem. 1973, 38, 23, 4002–4004Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/jo00987a009https://doi.org/10.1021/jo00987a009research-articleACS PublicationsRequest reuse permissionsArticle Views2217Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bosch - An alternate CO2 reduction technology (1979)

The Bosch process is the most promising CO2 reduction concept for future prolonged space missions. The paper presents the design of a three-person-capacity preprototype B-CRS (Bosch-based CO2 Reduction Subsystem). It is sized to reduce 3.0 kg/d CO2 generated by the crew and to supply the product water to an O2 generation subsystem to obtain O2. The design supports future development of the B-CRS as an alternative CO2 reduction subsystem to the Sabatier-based process presently under test at NASA. The discussion covers the Bosch CO2 reduction concept, process and hardware description, performance parameters, design specifications, subsystem schematic and operation, mechanical subsystem summary, control/monitor instrumentation, and subsystem packaging. A B-CRS with a proven technological base is an attractive CO2 reduction subsystem that eliminates overboard venting.
Maturation of Nitrogenase: a Biochemical Puzzle (2005)

The nitrogenase enzyme catalyzes the reductive breakage of the very strong triple bond of N2 to generate NH3 in a process known as biological nitrogen fixation. Biological nitrogen fixation is an essential step in the nitrogen cycle in the biosphere, and it is a major contributor to the nitrogen
Discriminative Reranking for Spoken Language Understanding (2011)

Spoken language understanding (SLU) is concerned with the extraction of meaning structures from spoken utterances. Recent computational approaches to SLU, e.g., conditional random fields (CRFs), optimize local models by encoding several features, mainly based on simple n-grams. In contrast, recent works have shown that the accuracy of CRF can be significantly improved by modeling long-distance dependency features. In this paper, we propose novel approaches to encode all possible dependencies between features and most importantly among parts of the meaning structure, e.g., concepts and their combination. We rerank hypotheses generated by local models, e.g., stochastic finite state transducers (SFSTs) or CRF, with a global model. The latter encodes a very large number of dependencies (in the form of trees or sequences) by applying kernel methods to the space of all meaning (sub) structures. We performed comparative experiments between SFST, CRF, support vector machines (SVMs), and our proposed discriminative reranking models (DRMs) on representative conversational speech corpora in three different languages: the ATIS (English), the MEDIA (French), and the LUNA (Italian) corpora. These corpora have been collected within three different domain applications of increasing complexity: informational, transactional, and problem-solving tasks, respectively. The results show that our DRMs consistently outperform the state-of-the-art models based on CRF.
Neurotrophin and neurotrophin receptor expression by cells of the human lamina cribrosa. (2001)

Cells from the human LC express mRNA and protein of neurotrophins and trk receptors. In addition, cells from the LC secrete neurotrophins, which suggests that there is paracrine and/or autocrine signaling within the LC. Neurotrophin signaling within this region of the ONH may play important roles in the maintenance of the normal LC and in such diseases as glaucoma.
Label-Free Imaging of Melanoma with Confocal Photothermal Microscopy: Differentiation between Malignant and Benign Tissue (2018)

Label-free confocal photothermal (CPT) microscopy was utilized for the first time to investigate malignancy in mouse skin cells. Laser diodes (LDs) with 405 nm or 488 nm wavelengths were used as pumps, and a 638 nm LD was used as a probe for the CPT microscope. A Grey Level Cooccurrence Matrix (GLCM) for texture analysis was applied to the CPT images. Nine GLCM parameters were calculated with definite definitions for the intracellular super-resolved CPT images, and the parameters Entropy, Contrast, and Variance were found to be most suited among the nine parameters to discriminate clearly between healthy cells and malignant cells when a 405 nm pump was used. Prominence, Variance, and Shade were most suited when a pump wavelength of 488 nm was used.
Recent developments in the field of iron‐sulfur proteins (1990)

This review considers recent information, in the following order, on complex proteins containing Fe-S clusters together with other prosthetic groups, on hydrogenases, unexpected functions of Fe-S clusters, novel cluster types, protein structures furnishing the cluster ligands, evolutionary aspects, and spectroscopic methods and theoretical approaches used or developed in the study of Fe-S proteins.
Fate of Midbrain Dopaminergic Neurons Controlled by the Engrailed Genes (2001)

Deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including Parkinson's disease, which is caused by the loss of dopaminergic neurons of the substantia nigra. We have investigated in mice the role of the engrailed homeodomain transcription factors, En-1 and En-2, in controlling the developmental fate of midbrain dopaminergic neurons. En-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral tegmentum, whereas En-2 is highly expressed by a subset of them. These neurons are generated and differentiate their dopaminergic phenotype in En-1/En-2 double null mutants, but disappear soon thereafter. Use of an En-1/tau-LacZ knock-in mouse as an autonomous marker for these neurons indicates that they are lost, rather than that they change their neurotransmitter phenotype. A single allele of En-1 on an En-2 null background is sufficient to produce a wild type-like substantia nigra and ventral tegmentum, whereas in contrast a single allele of En-2 on an En-1 null background results in the survival of only a small proportion of these dopaminergic neurons, a finding that relates to the differential expression of En-1 and En-2. Additional findings indicate that En-1 and En-2 regulate expression of alpha-synuclein, a gene that is genetically linked to Parkinson's disease. These findings show that the engrailed genes are expressed by midbrain dopaminergic neurons from their generation to adulthood but are not required for their specification. However, the engrailed genes control the survival of midbrain dopaminergic neurons in a gene dose-dependent manner. Our findings also suggest a link between engrailed and Parkinson's disease.
Safety and Immunogenicity of an Oral, Killed EnterotoxigenicEscherichia coli‐Cholera Toxin B Subunit Vaccine in Egyptian Adults (1998)

Enterotoxigenic Escherichia coli (ETEC) is the leading cause of bacterial diarrhea in young children in developing countries. The safety and immunogenicity of a killed, oral ETEC vaccine consisting of whole cells plus recombinantly produced cholera toxin B subunit (rCTB) was evaluated in Egypt, which is endemic for ETEC diarrhea. Seventy-four healthy Egyptian adults (21-45 years old) were randomized and received two doses of the ETEC/rCTB vaccine (E003) or placebo 2 weeks apart. The frequency of adverse events after either dose did not differ by treatment group, and no severe adverse events were reported. After vaccination, peripheral blood IgA B cell responses to CTB (100%) and to vaccine colonization factor antigens CFA/I (94%), CS4 (100%), CS2 (81%), and CS1 (69%) were significantly higher than response rates for the placebo group. These favorable results in Egyptian adults indicate that the ETEC/rCTB vaccine is a promising candidate for evaluation in younger age groups in this setting.
Teletext — enhancing the basic system (1979)

The UK teletext system specification includes provision for future developments. This paper indicates how the addressing structure may be used to allow selection from a very large number of pages either individually or by classification. Up to 64 totally independent data channels can also be provided. Various techniques for extending the character repertoire are described, depending on whether the extra characters are predefined, postdefined or dynamically redefined. Methods of increasing the security against errors are presented. It is suggested that within the framework of the existing teletext standard it is possible to work towards a system capable of giving a short sequence of colour pictures, whose quality is limited only by the television display itself. Any other requirements for the broadcasting of information for display on the television screen can then be treated as suboptions of such a system.
Automatic detection of left ventricular ejection time from a finger photoplethysmographic pulse oximetry waveform: comparison with Doppler aortic measurement (2007)

Left ventricular ejection time (LVET) is a useful measure of ventricular performance and preload. The present study explores a novel method of continuous LVET monitoring using a noninvasive finger photoplethysmographic pulse oximetry waveform (PPG-POW). A method for the automatic beat-to-beat detection of LVET from the finger PPG-POW is presented based on a combination of derivative analysis, waveform averaging and rule-based logic. The performance of the detection method was evaluated on 13 healthy subjects during graded head-up tilt. Overall, the correlation between the PPG-POW derived LVET and the aortic flow derived LVET was high and significant (r = 0.897, p < 0.05). The bias was -14 +/- 14 ms (mean +/- SD), and the percentage error was 9.7%. Although these results would not be sufficient to satisfy the requirement for clinical evaluation of LVET when absolute accuracy was demanded, the strong correlation between the PPG-POW LVET and the aortic LVET on an intra-subject basis (r = 0.945 +/- 0.043, mean +/- SD) would support the application of PPG-POW to detect the directional change in LVET of an individual. This could be very useful for the early identification of progressive hypovolaemia or blood loss. The present study has demonstrated a promising approach to extract potentially useful information from a noninvasive, easy-to-obtain signal that could be readily acquired either from existing patient monitoring equipment or from inexpensive instrumentation. More extensive investigation is necessary to evaluate the applicability of the present approach in clinical care monitoring.
Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns (1984)

Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosensitivity of the primary sensory neurons at different anatomic levels. Ectopic multiunit nerve activity correlating in intensity and time course to the positive sensory symptoms was recorded: when Tinel's sign was elicited in a patient with entrapment of the ulnar nerve at the elbow, when paresthesiae were provoked by elevation of the arm in a patient with symptoms consistent with a thoracic outlet syndrome, when paresthesiae were evoked by straining during chin-chest maneuver in a patient with an S1 syndrome due to a herniated lumbar disc, when a painful Lasegue's sign occurred during the straight-leg raising test in a patient with an S1 syndrome due to root fibrosis, and when Lhermitte's sign was elicited by neck flexion in a patient with multiple sclerosis. The sites for the ectopic impulse generation in these cases are suggested to be peripheral nerve, brachial plexus, dorsal root or dorsal root ganglion and dorsal columns. The paresthesiae were non-painful except in the patient with Lasegue's sign and the ectopic impulses were probably recorded from large myelinated afferent fibers.
Whey Fermentation by Anaerobiospirillum succiniciproducens for Production of a Succinate-Based Animal Feed Additive (1999)

Anaerobic fermentation processes for the production of a succinate-rich animal feed supplement from raw whey were investigated with batch, continuous, and variable-volume fed-batch cultures with Anaerobiospirillum succiniciproducens. The highest succinate yield, 90%, was obtained in a variable-volume fed-batch process in comparison to 80% yield in a batch cultivation mode. In continuous culture, succinate productivity was 3 g/liter/h, and the yield was 60%. Under conditions of excess CO2, more than 90% of the whey-lactose was consumed, with an end product ratio of 4 succinate to 1 acetate. Under conditions of limited CO2, lactose was only partially consumed and lactate was the major end product, with lower levels of ethanol, succinate, and acetate. When the succinic acid in this fermentation product was added to rumen fluid, it was completely consumed by a mixed rumen population and was 90% decarboxylated to propionate on a molar basis. The whey fermentation product formed under excess CO2, which contained mainly organic acids and cells, could potentially be used as an animal feed supplement.
Identification of a novel population of muscle stem cells in mice (2002)

Three populations of myogenic cells were isolated from normal mouse skeletal muscle based on their adhesion characteristics and proliferation behaviors. Although two of these populations displayed satellite cell characteristics, a third population of long-time proliferating cells expressing hematopoietic stem cell markers was also identified. This third population comprises cells that retain their phenotype for more than 30 passages with normal karyotype and can differentiate into muscle, neural, and endothelial lineages both in vitro and in vivo. In contrast to the other two populations of myogenic cells, the transplantation of the long-time proliferating cells improved the efficiency of muscle regeneration and dystrophin delivery to dystrophic muscle. The long-time proliferating cells' ability to proliferate in vivo for an extended period of time, combined with their strong capacity for self-renewal, their multipotent differentiation, and their immune-privileged behavior, reveals, at least in part, the basis for the improvement of cell transplantation. Our results suggest that this novel population of muscle-derived stem cells will significantly improve muscle cell-mediated therapies.
Molecular diversity of SIVsmm/PBj and a cognate variant, SIVsmm/PGg. (1991)

The molecular diversity of SIVsmm/PBj proviral genomes in tissues of an infected macaque was analyzed. Molecular clones derived directly from intestinal tissue DNA were heterogenous, and contained LTRs with one or two NF-kB binding sites. LTRs with one NF-kB site predominated (approximately 75%). Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection. These results suggest that either the duplicated NF-kB site acts in concert with other important viral determinants, or plays no role in producing the PBj syndrome.
In Vivo Self‐Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters (2017)

Additional surgeries for implantable biomedical devices are inevitable to replace discharged batteries, but repeated surgeries can be a risk to patients, causing bleeding, inflammation, and infection. Therefore, developing self‐powered implantable devices is essential to reduce the patient's physical/psychological pain and financial burden. Although wireless communication plays a critical role in implantable biomedical devices that contain the function of data transmitting, it has never been integrated with in vivo piezoelectric self‐powered system due to its high‐level power consumption (microwatt‐scale). Here, wireless communication, which is essential for a ubiquitous healthcare system, is successfully driven with in vivo energy harvesting enabled by high‐performance single‐crystalline (1 − x )Pb(Mg 1/3 Nb 2/3 )O 3 −( x )Pb(Zr,Ti)O 3 (PMN‐PZT). The PMN‐PZT energy harvester generates an open‐circuit voltage of 17.8 V and a short‐circuit current of 1.74 µA from porcine heartbeats, which are greater by a factor of 4.45 and 17.5 than those of previously reported in vivo piezoelectric energy harvesting. The energy harvester exhibits excellent biocompatibility, which implies the possibility for applying the device to biomedical applications.
An IC manufacturing yield model considering intra-die variations (2006)

In deep submicron feature sizes continue to shrink aggressively beyond the natural capabilities of the 193 nm lithography used to produce those features thanks to all the innovations in the field of resolution enhancement techniques (RET). With reduced feature sizes and tighter pitches die level variations become an increasingly dominant factor in determining manufacturing yield. Thus a prediction of design-specific features that impact intra-die variability and correspondingly its yield is extremely valuable as it allows for altering such features in a manner that reduces intra-die variability and improves yield. In this paper, a manufacturing yield model which takes into account both physical layout features and manufacturing fluctuations is proposed. The intra-die systematic variations are evaluated using a physics-based model as a function of a design's physical layout. The random variations and their across-die spatial correlations are obtained from data harvested from manufactured test structures. An efficient algorithm is proposed to reduce the order of the numerical integration in the yield model. The model can be used to (i) predict manufacturing yields at the design stage and (ii) enhance the layout of a design for higher manufacturing yield.
Interactions of Hairpin Oligo-2′-O-Methylribonucleotides Containing Methylphosphonate Linkages with HIV TAR RNA (2003)

Methylphosphonate-modified oligo-2'-O-methylribonucleotides 15-20 nucleotides (nt) in length were prepared whose sequences are complementary to the 5' and 3' sides of the upper hairpin of HIV trans-acting response element (TAR) RNA. These anti-TAR oligonucleotides (ODNs) form stable hairpins whose melting temperatures (Tm) range from 55 degrees C to 80 degrees C. Despite their rather high thermal stabilities, the hairpin oligo-2'-O-methylribonucleotides formed very stable complexes with TAR RNA, with dissociation constants in the nanomolar concentration range at 37 degrees C. The affinities of the hairpin oligomers for TAR RNA were influenced by the positions of the methylphosphonate linkages. The binding affinity was reduced approximately 17-fold by the presence of two methylphosphonate linkages in the TAR loop complementary region (TLCR) of the oligomer, whereas methylphosphonate linkages outside this region increased binding affinity approximately 3-fold. The configurations of the methylphosphonate linkages in the TLCR also affected binding affinity, with the RpRp isomer showing significantly higher binding than the SpSp isomer. In addition to serving as probes of the interactions between the oligomer and TAR RNA, the presence of the methylphosphonate linkages in combination with the hairpin structure increases the resistance of these oligomers to degradation by exonucleases found in mammalian serum. The combination of high binding affinity and nuclease resistance of the hairpin ODNs containing methylphosphonate linkages suggests their potential utility as antisense compounds.