gebhart/patrepeval huggingface dataset:
Flexible and scalable digital signatures in TPM 2.0 (2013)

Trusted Platform Modules (TPM) are multipurpose hardware chips, which provide support for various cryptographic functions. Flexibility, scalability and high performance are critical features for a TPM. In this paper, we present the new method for implementing digital signatures that has been included in TPM version 2.0. The core part of this method is a single TPM signature primitive, which can be called by different software programmes, in order to implement signature schemes and cryptographic protocols with different security and privacy features. We prove security of the TPM signature primitive under the static Diffie-Hellman assumption and the random oracle model. We demonstrate how to call this TPM signature primitive to implement anonymous signatures (Direct Anonymous Attestation), pseudonym systems (U-Prove), and conventional signatures (the Schnorr signature). To the best of our knowledge, this is the first signature primitive implemented in a limited hardware environment capable of supporting various signature schemes without adding additional hardware complexity compared to a hardware implementation of a conventional signature scheme.
Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension (2013)

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00902174 (core study); NCT01392495 (extension).
The effect of insulin-like growth factor I on postburn hypermetabolism. (1990)

These studies were undertaken to examine the effects of insulin-like growth factor I (IGF-I) on the hypermetabolic state that follows major thermal injury. Male Sprague-Dawley rats weighing 275 to 325 gm were subjected to a 50% total body surface area, full-thickness scald burn. At the time of injury, osmotic pumps were surgically implanted and used to deliver IGF-I, 1000 micrograms/day, or an equivalent volume of placebo solution by constant infusion of 5 microliters/hr for 14 days. Metabolic rates were studied with oxygen-consumption measurements performed on days 3, 7, 10, and 14 after injury. Animal weight measurements were also performed at the above intervals, with serum total IFG-I levels measured at death. Total serum IGF-I levels were decreased significantly 14 days after injury compared with uninjured animals (p less than 0.05). Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p less than 0.05). These data suggest that IGF-I causes a significant change in the metabolic response that follows severe thermal injury and point to a possible role for IGF-I in the treatment of patients after severe thermal injury.
Data reduction and data mining framework for digital forensic evidence: Storage, intelligence, review and archive (2014)

With the volume of digital forensic evidence rapidly increasing, this paper proposes a data reduction and data mining framework that incorporates a process of reducing data volume by focusing on a subset of information. Foreword The volume of digital forensic evidence is rapidly increasing, leading to large backlogs. In this paper, a Digital Forensic Data Reduction and Data Mining Framework is proposed. Initial research with sample data from South Australia Police Electronic Crime Section and Digital Corpora Forensic Images using the proposed framework resulted in significant reduction in the storage requirements—the reduced subset is only 0.196 percent and 0.75 percent respectively of the original data volume. The framework outlined is not suggested to replace full analysis, but serves to provide a rapid triage, collection, intelligence analysis, review and storage methodology to support the various stages of digital forensic examinations. Agencies that can undertake rapid assessment of seized data can more effectively target specific criminal matters. The framework may also provide a greater potential intelligence gain from analysis of current and historical data in a timely manner, and the ability to undertake research of trends over time.
Schottky Barriers in Carbon Nanotube Heterojunctions (2000)

Electronic properties of heterojunctions between metallic and semiconducting single-wall carbon nanotubes are investigated. Ineffective screening of the long-range Coulomb interaction in one-dimensional nanotube systems drastically modifies the charge transfer phenomena compared to conventional semiconductor heterostructures. The length of depletion region varies over a wide range sensitively depending on the doping strength. The Schottky barrier gives rise to an asymmetry of the I-V characteristics of heterojunctions, in agreement with recent experimental results by Yao et al. and Fuhrer et al. Dynamic charge buildup near the junction results in a steplike growth of the current at reverse bias.
Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. II. Isolation and characterization of phosphatidylserine auxotrophs. (1986)

Chinese hamster ovary (CHO) cell mutants that required exogenously added phosphatidylserine for cell growth were isolated by using the replica technique with polyester cloth, and three such mutants were characterized. Labeling experiments on intact cells with 32Pi and L-[U-14C]serine revealed that a phosphatidylserine auxotroph, designated as PSA-3, was strikingly defective in phosphatidylserine biosynthesis. When cells were grown for 2 days without phosphatidylserine, the phosphatidylserine content of PSA-3 was about one-third of that of the parent. In extracts of the mutant, the enzymatic activity of the base-exchange reaction of phospholipids with serine producing phosphatidylserine was reduced to 33% of that in the parent; in addition, the activities of base-exchange reactions of phospholipids with choline and ethanolamine in the mutant were also reduced to 1 and 45% of those in the parent, respectively. Furthermore, it was demonstrated that the serine-exchange activity in the parent was inhibited approximately 60% when choline was added to the reaction mixture whereas that in the mutant was not significantly affected. From the results presented here, we conclude the following. There are at least two kinds of serine-exchange enzymes in CHO cells; one (serine-exchange enzyme I) can catalyze the base-exchange reactions of phospholipids with serine, choline, and ethanolamine while the other (serine-exchange enzyme II) does not use the choline as a substrate. Serine-exchange enzyme I, in which mutant PSA-3 is defective, plays a major role in phosphatidylserine biosynthesis in CHO cells. Serine-exchange enzyme I is essential for the growth of CHO cells.
Highly spectrally efficient Ngara Rural Wireless Broadband Access Demonstrator (2012)

The cost of building high data rate (≈100 Mb/s per user) wireless internet access networks in rural areas can be significantly reduced by minimizing the number of access points to be deployed, each covering a larger area with a larger user capacity. Given that the available spectrum is limited even in rural areas especially at a lower frequency (VHF and UHF), which typically has an advantage of efficiently covering a larger area, the spectral efficiency of the access system needs to be improved many times over that currently feasible by commercially available technologies. We have developed a new technology suitable for wireless internet access in rural areas that achieved a spectral efficiency of 67 bits/s/Hz, which is believed to be the highest reported in the literature, on a practical low-cost hardware. This paper describes the highly spectrally efficient Ngara Rural Wireless Broadband Access Demonstrator.
Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects. (1994)

Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.
Sirtuin 2, a Mammalian Homolog of Yeast Silent Information Regulator-2 Longevity Regulator, Is an Oligodendroglial Protein That Decelerates Cell Differentiation through Deacetylating α-Tubulin (2007)

Silent information regulator-2 (SIR2) proteins regulate lifespan of diverse organisms, but their distribution and roles in the CNS remain unclear. Here, we show that sirtuin 2 (SIRT2), a mammalian SIR2 homolog, is an oligodendroglial cytoplasmic protein and localized to the outer and juxtanodal loops in the myelin sheath. Among cytoplasmic proteins of OLN-93 oligodendrocytes, alpha-tubulin was the main substrate of SIRT2 deacetylase. In cultured primary oligodendrocyte precursors (OLPs), SIRT2 emergence accompanied elevated alpha-tubulin acetylation and OLP differentiation into the prematurity stage. Small interfering RNA knockdown of SIRT2 increased the alpha-tubulin acetylation, myelin basic protein expression, and cell arbor complexity of OLPs. SIRT2 overexpression had the opposite effects, and counteracted the cell arborization-promoting effect of overexpressed juxtanodin. SIRT2 mutation concomitantly reduced its deacetylase activity and its impeding effect on OLP arborization. These results demonstrated a counterbalancing role of SIRT2 against a facilitatory effect of tubulin acetylation on oligodendroglial differentiation. Selective SIRT2 availability to oligodendroglia may have important implications for myelinogenesis, myelin-axon interaction, and brain aging.
Cytosolic Activation of Cathepsins Mediates Parvovirus H-1-Induced Killing of Cisplatin and TRAIL-Resistant Glioma Cells (2007)

Gliomas are often resistant to the induction of apoptotic cell death as a result of the development of survival mechanisms during astrocyte malignant transformation. In particular, the overexpression of Bcl-2-family members interferes with apoptosis initiation by DNA-damaging agents (e.g., cisplatin) or soluble death ligands (e.g., TRAIL). Using low-passage-number cultures of glioma cells, we have shown that parvovirus H-1 is able to induce death in cells resistant to TRAIL, cisplatin, or both, even when Bcl-2 is overexpressed. Parvovirus H-1 triggers cell death through both the accumulation of lysosomal cathepsins B and L in the cytosol of infected cells and the reduction of the levels of cystatin B and C, two cathepsin inhibitors. The impairment of either of these effects protects glioma cells from the viral lytic effect. In normal human astrocytes, parvovirus H-1 fails to induce a killing mechanism. In vivo, parvovirus H-1 infection of rat glioma cells intracranially implanted into recipient animals triggers cathepsin B activation as well. This report identifies for the first time cellular effectors of the killing activity of parvovirus H-1 against malignant brain cells and opens up a therapeutic approach which circumvents their frequent resistance to other death inducers.
Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations (2009)

Large-scale sequencing of cancer genomes has uncovered thousands of DNA alterations, but the functional relevance of the majority of these mutations to tumorigenesis is unknown. We have developed a computational method, called Cancer-specific High-throughput Annotation of Somatic Mutations (CHASM), to identify and prioritize those missense mutations most likely to generate functional changes that enhance tumor cell proliferation. The method has high sensitivity and specificity when discriminating between known driver missense mutations and randomly generated missense mutations (area under receiver operating characteristic curve, >0.91; area under Precision-Recall curve, >0.79). CHASM substantially outperformed previously described missense mutation function prediction methods at discriminating known oncogenic mutations in P53 and the tyrosine kinase epidermal growth factor receptor. We applied the method to 607 missense mutations found in a recent glioblastoma multiforme sequencing study. Based on a model that assumed the glioblastoma multiforme mutations are a mixture of drivers and passengers, we estimate that 8% of these mutations are drivers, causally contributing to tumorigenesis.
Isolation and Characterization of the Cytochrome P450 Gene CYP82E5v2 that Mediates Nicotine to Nornicotine Conversion in the Green Leaves of Tobacco (2007)

In the species of genus Nicotiana, nicotine to nornicotine conversion is mediated by closely related nicotine N-demethylase (NND) proteins that are encoded by the CYP82E subfamily of cytochrome P450 genes. The diverse number and transcriptional regulation of the NND genes have created large variations in the time and rate of nornicotine production in various Nicotiana species. In tobacco, previous studies have identified the senescence-inducible CYP82E4 gene as an important factor controlling nicotine conversion. Nornicotine is an undesirable alkaloid in tobacco, because it serves as a precursor for N'-nitrosonornicotine, a potent carcinogen in laboratory animals. The objective of this study was to investigate the possible catalytic roles of additional NND genes in shaping the alkaloid profile of tobacco. A PCR-based strategy using primers complementary to conserved regions of CYP82E genes yielded a cDNA, designated CYP82E5v2, which conferred NND activity in heterologous expression studies using yeast as a host. PCR amplification of CYP82E5v2 orthologs revealed that of the two progenitor species of tobacco, CYP82E5v2 was donated by the N. tomentosiformis parent. A comparison of CYP82E4 and CYP82E5v2 expression using qualitative real-time PCR analysis demonstrated that the transcription of CYP82E5v2 was higher in the green leaves of all tobacco genotypes tested, while the expression of CYP82E4 dominated in the senescing leaves of converter tobacco. These results suggest that differentially regulated NND genes regulate nornicotine production in the green and senescing leaves of tobacco and provide tools to reduce nornicotine levels in tobacco leaves.
Oxygen and the control of gene expression (1994)

The respiration of oxygen, while essential to aerobic organisms for the generation of energy, leads to the formation of reactive oxygen intermediates (ROIs) as harmful byproducts. ROIs damage nucleic acids, lipids and proteins. Therefore, protective mechanisms against elevated intracellular ROI levels, referred to as oxidative stress, have evolved. These include the activation of transcription factors which elevate the expression of protective enzymes. Eukaryotic cells have also evolved the ability to specifically generate ROIs following stimulation with various agents. In these cases, ROIs are used as second messengers to activate gene expression. Here we will discuss both prokaryotic and eukaryotic transcription factors that respond to ROIs. In addition, transcription factors will be described that are activated by either exposure to antioxidants, which reduce the intracellular ROI concentration, or by hypoxia, the absence of oxygen.
The ultimate CMOS device and beyond (2012)

For the past 40 years, relentless focus on Moore's Law transistor scaling has delivered ever-improving CMOS transistor density. This paper discusses architectural and materials options which will contribute to the ultimate CMOS device. In addition, the paper reviews device options beyond the ultimate CMOS device.
Jules-César Scaliger, La Poétique V, Le Critique, Présentation, traduction et notes de Jacques Chomarat (1994)

Weber Henri. Jules-César Scaliger, La Poétique V, Le Critique, Présentation, traduction et notes de Jacques Chomarat. In: Bulletin de l'Association d'étude sur l'humanisme, la réforme et la renaissance, n°39, 1994. pp. 128-129.
Gastrointestinal and Cardiovascular Risk of NonsteroidalAnti-inflammatory Drugs (2011)

Nonsteroidal anti-inflammatory drugs (NSAIDs) confer a gastrointestinal (GI) side effect profile and concerns regarding adverse cardiovascular effects have emerged associated with considerable morbidity and mortality. NSAIDs are highly effective in treating pain and inflammation, but it is well recognized that these agents are associated with substantial gastrointestinal toxicity. Cyclo-oxygenase-2 inhibitors may also reduce the risk for gastrointestinal events, although they may increase cardiovascular adverse events. The selection of an appropriate analgesic or anti-inflammatory agent with or without gastroprotective therapy should be individualized.
Quin 2: the dissociation constants of its Ca2+ and Mg2+ complexes and its use in a fluorimetric method for determining the dissociation of Ca2+-protein complexes (1985)

Fluorimetric or spectrophotometric titrations with the appropriate cations gave Kd values of 2.9 +/- 0.2 nM and 89 +/- 5 microM respectively for the Ca2+ and Mg2+ complexes of quin 2 at pH 7.5. Mixtures of quin 2 and vitamin D-dependent Ca2+-binding protein from pig duodenum were titrated fluorimetrically with Ca2+ in the absence or presence of Mg2+. These measurements were used with the Kd values of the Ca2+ and Mg2+ complexes of quin 2 to obtain Kd or apparent Kd values for Ca2+-protein complexes ranging from 5 nM to 5 microM with good accuracy.
Effects of α-lipoic acid on cell proliferation and apoptosis in MDA-MB-231 human breast cells (2009)

The role that antioxidants play in the process of carcinogenesis has recently gained considerable attention. alpha-Lipoic acid, a naturally occurring disulfide molecule, is a powerful antioxidant that reportedly exerts beneficial effects in patients with advanced cancer by reducing the level of reactive oxygen species and increasing glutathione peroxidase activity. In this study, we examined changes in the protein and mRNA expression associated with cell proliferation and apoptosis in MDA-MB-231 breast cancer cultured in the presence of various concentrations (0, 250, 500, and 1000 micromol/L) of alpha-lipoic acid. The results revealed that alpha-lipoic acid inhibited the growth of breast cancer cells in a dose-independent manner (P < 0.05). Additionally, ErbB(2) and ErbB(3) protein and mRNA expressions were significantly decreased in a dose-dependent manner in response to alpha-lipoic acid (P < 0.05). Furthermore, the protein expression of phosphorylated Akt (p-Akt) levels and total Akt, and the mRNA expression of Akt were decreased dose-dependently in cells that were treated with alpha-lipoic acid (P < 0.05). Bcl-2 protein and mRNA expressions were also decreased in cells that were treated with alpha-lipoic acid (P < 0.05). However, Bax protein and mRNA expressions were increased in cells treated with alpha-lipoic acid (P < 0.05). Finally, caspase-3 activity was significantly increased in a dose-dependent manner in cells treated with alpha-lipoic acid (P < 0.05). In conclusion, we demonstrated that alpha-lipoic acid inhibits cell proliferation and induces apoptosis in MDA-MB-231 breast cancer cell lines.
A Simple Framework for Contrastive Learning of Visual Representations (2020)

This paper presents SimCLR: a simple framework for contrastive learning of visual representations. We simplify recently proposed contrastive self-supervised learning algorithms without requiring specialized architectures or a memory bank. In order to understand what enables the contrastive prediction tasks to learn useful representations, we systematically study the major components of our framework. We show that (1) composition of data augmentations plays a critical role in defining effective predictive tasks, (2) introducing a learnable nonlinear transformation between the representation and the contrastive loss substantially improves the quality of the learned representations, and (3) contrastive learning benefits from larger batch sizes and more training steps compared to supervised learning. By combining these findings, we are able to considerably outperform previous methods for self-supervised and semi-supervised learning on ImageNet. A linear classifier trained on self-supervised representations learned by SimCLR achieves 76.5% top-1 accuracy, which is a 7% relative improvement over previous state-of-the-art, matching the performance of a supervised ResNet-50. When fine-tuned on only 1% of the labels, we achieve 85.8% top-5 accuracy, outperforming AlexNet with 100X fewer labels.
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24 (1996)

DNA sequence analysis of a region of the Streptomyces sp. strain C5 daunomycin biosynthesis gene cluster, located between the daunomycin polyketide biosynthesis gene cluster and a dnrI (transcriptional activator) homolog, revealed the presence of a gene encoding a P-450-like enzyme with a deduced Mr of 46,096. Expression of this gene, named herein doxA, in Streptomyces lividans TY24 resulted in in vivo bioconversion of daunomycin to doxorubicin. DoxA showed specificity for only daunomycin and 13-dihydrodaunomycin, both of which were converted to doxorubicin. Daunomycinone (daunomycin aglycone), carminomycin, 13-dihydrocarminomycin, idarubicin, and aklavin were not apparent substrates for DoxA. In vector controls or in vectors in which doxA was poorly expressed, S. lividans catalyzed the reduction of daunomycin and other 13-oxo-anthracyclines and -anthracyclinones to their 13-dihydro homologs.
TCP westwood (2001)

TCP Westwood (TCPW) is a sender-side modification of the TCP congestion window algorithm that improves upon the performance of TCP Reno in wired as well as wireless networks. The improvement is most significant in wireless networks with lossy links, since TCP Westwood relies on end-to-end bandwidth estimation to discriminate the cause of packet loss (congestion or wireless channel effect) which is a major problem in TCP Reno. An important distinguishing feature of TCP Westwood with respect to previous wireless TCP “extensions” is that it does not require inspection and/or interception of TCP packets at intermediate (proxy) nodes. Rather, it fully complies with the end-to-end TCP design principle. The key innovative idea is to continuously measure at the TCP source the rate of the connection by monitoring the rate of returning ACKs. The estimate is then used to compute congestion window and slow start threshold after a congestion episode, that is, after three duplicate acknowledgments or after a timeout. The rationale of this strategy is simple: in contrast with TCP Reno, which “blindly” halves the congestion window after three duplicate ACKs, TCP Westwood attempts to select a slow start threshold and a congestion window which are consistent with the effective bandwidth used at the time congestion is experienced. We call this mechanism faster recovery. The proposed mechanism is particularly effective over wireless links where sporadic losses due to radio channel problems are often misinterpreted as a symptom of congestion by current TCP schemes and thus lead to an unnecessary window reduction. Experimental studies reveal improvements in throughput performance, as well as in fairness. In addition, friendliness with TCP Reno was observed in a set of experiments showing that TCP Reno connections are not starved by TCPW connections. Most importantly, TCPW is extremely effective in mixed wired and wireless networks where throughput improvements of up to 550% are observed. Finally, TCPW performs almost as well as localized link layer approaches such as the popular Snoop scheme, without incurring the O/H of a specialized link layer protocol.