gebhart/patrepeval huggingface dataset:
Dammarenediol‐II synthase, the first dedicated enzyme for ginsenoside biosynthesis, in Panax ginseng (2006)

Panax ginseng produces triterpene saponins called ginsenosides, which are classified into two groups by the skeleton of aglycones, namely dammarane type and oleanane type. Dammarane-type ginsenosides dominate over oleanane type not only in amount but also in structural varieties. However, their sapogenin structure is restricted to two aglycones, protopanaxadiol and protopanaxatriol. So far, the genes encoding oxidosqualene cyclase (OSC) responsible for formation of dammarane skeleton have not been cloned, although OSC yielding oleanane skeleton (beta-amyrin synthase) has been successfully cloned from this plant. In this study, cDNA cloning of OSC producing dammmarane triterpene was attempted from hairy root cultures of P. ginseng by homology based PCR method. A new OSC gene (named as PNA) obtained was expressed in a lanosterol synthase deficient (erg7) Saccharomyces cerevisiae strain GIL77. LC-MS and NMR analyses identified the accumulated product in the yeast transformant to be dammarenediol-II, demonstrating PNA to encode dammarenediol-II synthase.
Basic fibroblast growth factor enhances myocardial collateral flow in a canine model (1994)

Basic fibroblast growth factor (FGF) is a multifunctional peptide that may play an integral role in angiogenesis associated with coronary collateral formation and myocardial infarct healing. We sought to determine the effects of exogenously administered basic FGF on collateral blood flow to ischemic myocardium. Ameroid constrictors were used to cause gradual occlusion of the left circumflex coronary artery in dogs. Basic FGF (110 micrograms, n = 9) or saline (n = 12) was given as a daily bolus injection directly into the collateral-dependent zone, beginning 10 days after placement of the Ameroid and continuing for 28 days. Collateral flow was assessed weekly as the ratio of collateral to normal zone (CZ/NZ) blood flow during maximal pharmacologically induced coronary vasodilation. The CZ/NZ increased in both treated and control dogs as a function of time; however, transmural collateral flow in basic FGF-treated dogs significantly exceeded that of control dogs by the second week of treatment. Final CZ/NZ blood flow ratios were 0.49 +/- 0.05 and 0.35 +/- 0.02 in the treated and control groups, respectively (means +/- SE, P = 0.0002). Treatment with basic FGF was also associated with significant increases in the numerical density of distribution vessels and endothelial cell DNA synthesis within the CZ. We also found that basic FGF had acute effects as a coronary vasodilator. Thus exogenous administration of basic FGF enhances maximal collateral blood flow in dogs with myocardial ischemia secondary to single-vessel coronary occlusion, an effect that is likely mediated through the direct angiogenic effects of the peptide, although its acute vasodilatory effects may also play a role.
c-Myb a stem-progenitor cell regulator in multiple tissue compartments (2005)

KeywordsAdult neurogenesiscolonic cryptshematopoiesismouse knock-outshypomorphic mutantsradiation response
Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis (2012)

Chronic-progressive MS disease courses show a pronounced reduction of the cerebral shear elasticity compared to early relapsing-remitting disease. The powerlaw exponent α decreased only in the chronic-progressive stage of MS, suggesting an alteration in the geometry of the cerebral mechanical network due to chronic neuroinflammation.
"Beringuella,...ella"": le plaisir des formes dans l´écriture dramatique de Lucas Fernández (2008)

A través del estudio de las estrofas 1 y 6 del monólogo con el cual se abre la Comedia hecha por Lucas Fernández en lenguaje e estilo pastoril, se intenta mostrar que los procedimientos estilísticos acumulados por el dramaturgo, aunque aparentemente propios de la retórica poética, están clara y específicamente puestos al servicio de la técnica dramática y de las situaciones escénicas.
Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD (2013)

The amygdala-dependent molecular mechanisms driving the onset and persistence of posttraumatic stress disorder (PTSD) are poorly understood. Recent observational studies have suggested that opioid analgesia in the aftermath of trauma may decrease the development of PTSD. Using a mouse model of dysregulated fear, we found altered expression within the amygdala of the Oprl1 gene (opioid receptor-like 1), which encodes the amygdala nociceptin (NOP)/orphanin FQ receptor (NOP-R). Systemic and central amygdala infusion of SR-8993, a new highly selective NOP-R agonist, impaired fear memory consolidation. In humans, a single-nucleotide polymorphism (SNP) within OPRL1 is associated with a self-reported history of childhood trauma and PTSD symptoms (n = 1847) after a traumatic event. This SNP is also associated with physiological startle measures of fear discrimination and magnetic resonance imaging analysis of amygdala-insula functional connectivity. Together, these data suggest that Oprl1 is associated with amygdala function, fear processing, and PTSD symptoms. Further, our data suggest that activation of the Oprl1/NOP receptor may interfere with fear memory consolidation, with implications for prevention of PTSD after a traumatic event.
Human Prostate Carcinogenesis (1997)

Prostate cancer is a major medical problem that is expected to affect over 300,000 American men and cause over 40,000 deaths in 1997. Despite its widespread prevalence and because of the difficulties in clinical diagnosis and treatment of the disease, the etiological mechanism underlying prostate carcinogenesis remains poorly understood. Elucidation of the mechanism of prostate tumorigenesis has been slowed by a lack of tumor tissues and the limited number of human cell lines available for study. In vitro human cell models to study the molecular biology of prostate cancer progression are urgently needed. Normal human prostate cells require immortalization to provide a practical system for transformation studies. Neoplastic transformation of human prostate epithelial cells in culture has been achieved recently in a stepwise fashion--immortalization of primary cells in culture and conversion of the immortalized cells to a tumorigenic state. Reviewed here are the steps involved in the neoplastic transformation of human prostate cells. To provide an insight into the molecular and genetic mechanisms involved in the conversion of normal cells to a neoplastic state of growth, the authors have attempted to put into perspective the history of human prostate epithelial cell transformation by a combination of carcinogenic agents, and to discuss the current state-of-the-art in transformation of human prostate epithelial cells in culture.
Mitosis Through the Microscope: Advances in Seeing Inside Live Dividing Cells (2003)

The most visually spectacular events in the life of a cell occur when it divides. This is especially true in higher eukaryotes, where the size and geometry of cells allow the division process to be followed through a microscope with considerable clarity. In these organisms, the membrane surrounding the nucleus breaks down after the replicated DNA has condensed to form discrete chromosomes. Several new structures are then assembled to separate the chromosomes and partition the cytoplasm into two separate cells.
Effects of oral administration of positively charged insulin liposomes on alloxan diabetic rats: Preliminary study. (1979)

Insulin encapsulated in liposomes of various lipid compositions were prepared. The amount of insulin trapped in these liposomes increased in the order, negatively charged liposomes less than neutral liposomes less than positively charged liposomes. In positively charged liposomes, the amount of insulin trapped increased with increase in the amount of amphiphile stearylamine. Under the conditions tested, the highest insulin content (about 50%) was obtained with liposomes composed of phosphatidyl choline/cholesterol/stearylamine in a molar ratio of 7/2/2.25. These liposomes were stable on incubation for 3 hr at 37 degrees C in solutions of pepsin, trypsin, and pancreatin, and after these incubations, a considerable amount of insulin was still associated with the liposomes. However, the liposomes released almost all the insulin into the medium on treatment with bile. When the liposomes were administered orally to rats in the 3rd phase of acute alloxan diabetes, reduction of the blood glucose level was observed in 7 of 11 animals, the reduction persisted for several hours and was ranging from 30 to 75%. In alloxan diabetic rats showing hyperglycemia for 3 to 6 months, the liposomes also increased the glucose tolerance in half the animals tested.
Reaction of Gae-Phase Atomic Hydrogen with Chemisorbed Hydrogen Atoms on an Iron Surface (1997)

The reaction of gas-phase atomic hydrogen with hydrogen atoms chemisorbed on Fe(110) surface is studied by use of classical trajectory procedures. Flow of energy between the reaction zone and bulk solid phase has been treated in the generalized Langevin equation approach. A London-Eyring-Polanyi-Sato energy surface is used for the reaction zone interaction. Most reactive events are found to occur in strong single-impact collisions on a subpicosecond scale via the Eley-Rideal mechanism. The extent of reaction is large and a major fraction of the available energy goes into the vibrational excitation of H2, exhibiting a vibrational population inversion. Dissipation of reaction energy to the heat bath can be adequately described using a seven-atom chain with the chain end bound to the rest of solid. The extent of reaction is not sensitive to the variation of surface temperature in the range of Ts=0-300 K in the fixed gas temperature, but it shows a minimum near 1000 K over the Tg=300-2500 K.
Nonlinear Resonant Generator for Harvesting Energy from Human Wrist Vertical Shaking (2011)

Based on the structure of permanent magnet (PM) spring, composed of one fixed end magnet and one moving magnet, a nonlinear resonant electromagnetic micro-generator is designed, which is suitable for human wrist vertical shaking and can be used as an emergency power source for portable electronic products, such as cell phone. Generator model is built under the condition of resistive load, which has been solved numerically through simulation. The model is validated by the measured results and can be used for further study of generator optimization and power processing circuits. The experimental results show that the prototype could generate power as high as 50 mW under the condition of simple harmonic driving acceleration with the amplitude of 0.8 g (7.84 m/s 2 ) and the frequency of 3.33 Hz.
Multimedia description framework (MDF) for content description of audio/video documents (1999)

MPEG is undertaking a new initiative to standardize content description of audio and video data/documents. When it is finalized in 2001, MPEG-7 is expected to provide standardized description language and schemes for concise and unambiguous content description of data/documents of complex media types. Meanwhile, other meta-data or description schemes, such as Dublin Core, XML, RDF, etc., are becoming popular in different application domains. In this paper, we propose Multimedia Description Framework (MDF), which is designated to accommodate multiple description (meta-data) schemes, MPEG-7 and non-MPEG-7, into integrated architecture. We will u`se examples to show how MDF description makes use of combined strength of different description schemes to enhance its expression power and flexibility. We conclude the paper with discussion of using MDF description of MPEG-7 Content Set to search/retrieve required audio and video documents from the set utilizing an MDF prototype system we have implemented.
Fourth-factor authentication (2006)

User authentication in computing systems traditionally depends on three factors: something you have (e.g., a hardware token), something you are (e.g., a fingerprint), and something you know (e.g., a password). In this paper, we explore a fourth factor, the social network of the user, that is, somebody you know.Human authentication through mutual acquaintance is an age-old practice. In the arena of computer security, it plays roles in privilege delegation, peer-level certification, help-desk assistance, and reputation networks. As a direct means of logical authentication, though, the reliance of human being on another has little supporting scientific literature or practice.In this paper, we explore the notion of vouching, that is, peer-level, human-intermediated authentication for access control. We explore its use in emergency authentication, when primary authenticators like passwords or hardware tokens become unavailable. We describe a practical, prototype vouching system based on SecurID, a popular hardware authentication token. We address traditional, cryptographic security requirements, but also consider questions of social engineering and user behavior.
Neurotoxicity of Taxol. (1993)

Neurotoxicity, manifested primarily by a motor and sensory polyneuropathy, is the principal nonhematological side effect of Taxol. Available evidence suggests that Taxol produces a toxic effect involving either axons or ganglion cell bodies, or both, rather than a myelinopathy. As with other toxic polyneuropathies, patients with preexisting peripheral neuropathies, such as those caused by diabetes mellitus or ethanol, appear to be particularly predisposed to developing neurological toxicity. The incidence and severity of the neuropathic manifestations also appear to be related to the Taxol dose level, the cumulative dose of Taxol, and possibly to the use of Taxol in combination with cisplatin. Rarely, manifestations of autonomic and central nervous system dysfunction occur. Taxol also induces myalgias in the peri-treatment period, especially when used in high doses, and a myopathy has been noted in patients treated with high doses of Taxol administered alone and in combination with cisplatin. Although dose-response relationships for Taxol have not been clearly established, these neuromuscular effects are likely to become a significant clinical problem if higher doses of Taxol are used with hematopoietic colony-stimulating factors. The neuromuscular effects of Taxol, including symptoms, physical and electrophysiological manifestations, and predisposing factors, as well as agents that may be used for neuroprotection, are discussed in this report.
Thermal stability of the strained-Si/Si0.7Ge0.3 heterostructure (2001)

Thermal stability of the strained-Si/Si0.7Ge0.3 heterostructure was investigated by secondary-ion mass spectroscopy, Raman spectroscopy, and atomic force microscopy. Ge atoms diffused out through the strained-Si layer during heat treatment of 1000 °C for 1 h. The activation energy of Ge diffusion in strained Si was 3.3 eV, which was lower than the value in unstrained Si (4.7–5.3 eV). Strain in the strained-Si layer did not change after thermal treatment at 950 °C or less for 1 h. Slip lines due to strain relaxation formed at the surface of the strained-Si layer for the samples treated at 950–1000 °C for 1 h. For practical application of the strained-Si/Si0.7Ge0.3 heterostructure to electron devices, the maximum thermal budget should be made less than that equivalent to 900 °C annealing for 1 h.
Sub-10-nm high aspect ratio patterning of ZnO in a 500μm main field (2006)

We demonstrate the fabrication of sub-10-nm high aspect ratio electron beam patterning of ZnO at the center as well as corners of the 500μm square main deflection field using a negative tone zinc naphthenate resist. After electron beam exposure, the resist was developed in toluene, resulting in high-resolution patterns as small as 7nm with an aspect ratio of ∼10 in the center as well as at the corners of the main field. The line edge roughness (3σ) of these lines shows roughness with fluctuations of about 2.8nm; thus making it the smallest value of the line edge roughness measured so far for any electron beam resist. Heating the structures at 500°C resulted in reduction of feature sizes to ∼5nm and in the formation of crystalline ZnO. Such sub-10-nm high aspect ratio patterning within the main deflection field is an important step to enable full-wafer-level nanofabrication.
Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ( TMS) on the Negative Symptoms of Schizophrenia (2005)

Previous research in clinical electroencephalography (EEG) has demonstrated that reduction of alpha frequency (8-13 Hz) EEG activity may have particular relevance to the negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) was utilized to investigate this relationship by assessing the therapeutic effects of stimulation set individually at each subject's peak alpha frequency (alphaTMS). Twenty-seven subjects, with predominantly negative symptom schizophrenia, received 2 weeks of daily treatment with either alphaTMS, 3 Hz, 20 Hz, or sham stimulation bilaterally over the dorsolateral prefrontal cortex. Individualized alphaTMS demonstrated a significantly larger (F (3,33) = 4.7, p = .007) therapeutic effect (29.6% reduction in negative symptoms) than the other 3 conditions (< 9%). Furthermore, these clinical improvements were found to be highly correlated (r = 0.86, p = .001) with increases (34%) in frontal alpha amplitude following alphaTMS. These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia and merit further investigation as a particularly efficacious frequency for rTMS treatments.
Polarization mode converter with polyimide half waveplate in silica-based planar lightwave circuits (1994)

A TE/TM polarization mode converter, with an excess loss of 0.26 dB, is constructed by inserting a polyimide half waveplate into a groove formed in a silica-based single mode waveguide. The polarization dependence of an arrayed-waveguide grating multiplexer is completely eliminated with this mode converter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4 (2008)

The generation of reactive oxygen species is a central feature of inflammation that results in the oxidation of host phospholipids. Oxidized phospholipids, such as 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC), have been shown to inhibit signaling induced by bacterial lipopeptide or lipopolysaccharide (LPS), yet the mechanisms responsible for the inhibition of Toll-like receptor (TLR) signaling by OxPAPC remain incompletely understood. Here, we examined the mechanisms by which OxPAPC inhibits TLR signaling induced by diverse ligands in macrophages, smooth muscle cells, and epithelial cells. OxPAPC inhibited tumor necrosis factor-alpha production, IkappaBalpha degradation, p38 MAPK phosphorylation, and NF-kappaB-dependent reporter activation induced by stimulants of TLR2 and TLR4 (Pam3CSK4 and LPS) but not by stimulants of other TLRs (poly(I.C), flagellin, loxoribine, single-stranded RNA, or CpG DNA) in macrophages and HEK-293 cells transfected with respective TLRs and significantly reduced inflammatory responses in mice injected subcutaneously or intraperitoneally with Pam3CSK4. Serum proteins, including CD14 and LPS-binding protein, were identified as key targets for the specificity of TLR inhibition as supplementation with excess serum or recombinant CD14 or LBP reversed TLR2 inhibition by OxPAPC, whereas serum accessory proteins or expression of membrane CD14 potentiated signaling via TLR2 and TLR4 but not other TLRs. Binding experiments and functional assays identified MD2 as a novel additional target of OxPAPC inhibition of LPS signaling. Synthetic phospholipid oxidation products 1-palmitoyl-2-(5-oxovaleryl)-sn-glycero-3-phosphocholine and 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibited TLR2 signaling from approximately 30 microm. Taken together, these results suggest that oxidized phospholipid-mediated inhibition of TLR signaling occurs mainly by competitive interaction with accessory proteins that interact directly with bacterial lipids to promote signaling via TLR2 or TLR4.
Spasmodic Dysphonia: Emotional Status and Botulinum Toxin Treatment (1994)

The objectives of this study were to determine the effects of botulinum toxin injection on measures of depression, anxiety, and somatic complaints in patients diagnosed as having spasmodic dysphonia. Patients were asked to complete preinjection questionnaires with self-ratings of depression, state and trait anxiety, and somatic complaints. Approximately 1 week and 2 months following injection, patients were again asked to complete the questionnaires. The spasmodic dysphonic subjects exhibited significantly elevated mean levels of depression and anxiety. These levels were significantly reduced approximately 1 week after injection. Two months later, depression and anxiety measures did not change significantly from their 1-week postinjection values. The results suggest that patients with spasmodic dysphonia who demonstrate significantly elevated measures of depression and anxiety show a reduction in those measures following treatment with botulinum toxin.
World's first monolithic 3D-FPGA with TFT SRAM over 90nm 9 layer Cu CMOS (2010)

World's first monolithically integrated Thin-Film-Transistor (TFT) SRAM configuration circuits over 90nm 9 layers of Cu interconnect CMOS is successfully fabricated at 300mm LSI mass production line for 3-dimensional Field Programmable Gate Arrays (3D-FPGA). This novel technology built over the 9 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> layer of Cu metal features aggressively scaled amorphous Si TFT having 180nm transistor gate length, 20nm gate oxide, fully silicided gate, S/D, all below 400C processing essential to not impact underlying Cu interconnects. Low temperature TFT devices show excellent NTFT/PTFT transistor I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">on</sub> /I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> ratios over 2000/100 respectively, operate at 3.3V, E-field scalable, and are stable for SRAM configuration circuits. We believe this 3D-TFT technology is a major breakthrough innovation to overcome the conventional CMOS device shrinking limitation.
Stoichiometric and Catalytic H/D Incorporation by Cationic Iridium Complexes:  A Common Monohydrido-Iridium Intermediate (2004)

A mechanistic study of the stoichiometric and catalytic H/D exchange reactions involving cationic iridium complexes is presented. Strong evidence suggests that both stoichiometric and catalytic reactions proceed via a monohydrido-iridium species. Stoichiometric deuterium incorporation reactions introduce multiple deuterium atoms into the organic products when aryliridium compounds CpPMe(3)Ir(C(6)H(4)X)(OTf) (X = H, o-CH(3), m-CH(3), p-CH(3)) react with D(2). Multiple deuteration occurs at the unhindered positions (para and meta) of toluene, when X = CH(3). The multiple-deuteration pathway is suppressed in the presence of an excess of the coordinating ligand, CH(3)CN. The compound CpPMe(3)IrH(OTf) (1-OTf) is observed in low-temperature, stoichiometric experiments to support a monohydrido-iridium intermediate that is responsible for catalyzing multiple deuteration in the stoichiometric system. When paired with acetone-d(6)(), [CpPMe(3)IrH(3)][OTf] (4) catalytically deuterates a wide range of substrates with a variety of functional groups. Catalyst 4 decomposes to [CpPMe(3)Ir(eta(3)-CH(2)C(OH)CH(2))][OTf] (19) in acetone and to [CpPMe(3)IrH(CO)][OTf] (1-CO) in CH(3)OH. The catalytic H/D exchange reaction is not catalyzed by simple H(+) transfer, but instead proceeds by a reversible C-H bond activation mechanism.