gebhart/patrepeval huggingface dataset:
Wearable, Cuff-less PPG-Based Blood Pressure Monitor with Novel Height Sensor (2006)

A truly wearable non-invasive blood pressure (NIBP) sensor--light-weight, compact, unobstrusive, and essentially unnoticeable to the patient--could revolutionize healthcare delivered beyond the traditional walls of medical facilities, offering new ways to care for patients in their everyday surroundings. This paper presents results from our work towards the development of a self-contained, wearable blood pressure sensor. A PPG-based approach to blood pressure monitoring is presented. The design enables significant miniaturization of traditional oscillometric devices without the need for occlusive circumferential pressures. It will be shown how natural raising and lowering of the arm replaces the need for bulky actuators. Additionally, a dual-accelerometer height sensor that is tetherless is proposed and supported by experimental results.
Single-crystalline Ni(OH)2 and NiO nanoplatelet arrays as supercapacitor electrodes (2011)

Vertically aligned Ni(OH)2 and NiO single-crystalline nanoplatelet arrays were directly grown on the fluorine-doped tin oxide (FTO) substrate by a simple hydrothermal method. The effects of the hydrothermal parameters on the morphology and crystal structure of the nanoarray film were investigated. Controlling the ammonia and persulfate concentrations was the key to controlling the morphology of the nanoarray film. The experimental results showed that the single-crystalline NiO nanoplatelet array was a promising candidate for the supercapacitor electrode. It exhibited a high specific capacitance, prompt charge/discharge rate, and good stability of cycling performance. It is believed that the vertically oriented aligned single-crystalline NiO nanoplatelet array is beneficial to the charge transfer in the electrode and to the ion transport in the solution during redox reaction.
Heme-Protein Active Site Models via Self-Assembly in Water (2003)

[structure: see text] Water-soluble models of heme-protein active sites are obtained via the self-assembly of cationic porphyrins 1 and tetrasulfonato calix[4]arene 2 (K(1.2)() = 10(5) M(-)(1)). Selective binding of ligands either outside or inside the cavity of assemblies 1.2 via coordination to the zinc center has been observed. Small ligands such as 4-methylpyridine and 1-methylimidazole are encapsulated, while the bulkier caffeine is bound outside. Assemblies Co-1.2, in which the Zn porphyrin moiety has been replaced by a Co(II) porphyrin, can act as O(2) carriers.
Release of Reactive Oxygen Intermediates (Superoxide Radicals, Hydrogen Peroxide, and Hydroxyl Radicals) and Peroxidase in Germinating Radish Seeds Controlled by Light, Gibberellin, and Abscisic Acid (2001)

Germination of radish (Raphanus sativus cv Eterna) seeds can be inhibited by far-red light (high-irradiance reaction of phytochrome) or abscisic acid (ABA). Gibberellic acid (GA3) restores full germination under far-red light. This experimental system was used to investigate the release of reactive oxygen intermediates (ROI) by seed coats and embryos during germination, utilizing the apoplastic oxidation of 2',7'-dichlorofluorescin to fluorescent 2',7'-dichlorofluorescein as an in vivo assay. Germination in darkness is accompanied by a steep rise in ROI release originating from the seed coat (living aleurone layer) as well as the embryo. At the same time as the inhibition of germination, far-red light and ABA inhibit ROI release in both seed parts and GA3 reverses this inhibition when initiating germination under far-red light. During the later stage of germination the seed coat also releases peroxidase with a time course affected by far-red light, ABA, and GA3. The participation of superoxide radicals, hydrogen peroxide, and hydroxyl radicals in ROI metabolism was demonstrated with specific in vivo assays. ROI production by germinating seeds represents an active, developmentally controlled physiological function, presumably for protecting the emerging seedling against attack by pathogens.
Foot-and-Mouth Disease Virus: Immunobiology, Advances in Vaccines and Vaccination Strategies Addressing Vaccine Failures—An Indian Perspective (2019)

A mass vaccination campaign in India seeks to control and eventually eradicate foot-and-mouth disease (FMD). Biosanitary measures along with FMD monitoring are being conducted along with vaccination. The implementation of the FMD control program has drastically reduced the incidence of FMD. However, cases are still reported, even in regions where vaccination is carried out regularly. Control of FMD outbreaks is difficult when the virus remains in circulation in the vaccinated population. Various FMD risk factors have been identified that are responsible for FMD in vaccinated areas. The factors are discussed along with strategies to address these challenges. The current chemically inactivated trivalent vaccine formulation containing strains of serotype O, A, and Asia 1 has limitations including thermolability and induction of only short-term immunity. Advantages and disadvantages of several new-generation alternate vaccine formulations are discussed. It is unfeasible to study every incidence of FMD in vaccinated animals/areas in such a big country as India with its huge livestock population. However, at the same time, it is absolutely necessary to identify the precise reason for vaccination failure. Failure to vaccinate is one reason for the occurrence of FMD in vaccinated areas. FMD epidemiology, emerging and re-emerging virus strains, and serological status over the past 10 years are discussed to understand the impact of vaccination and incidences of vaccination failure in India. Other factors that are important in vaccination failure that we discuss include disrupted herd immunity, health status of animals, FMD carrier status, and FMD prevalence in other species. Recommendations to boost the search of alternate vaccine formulation, strengthen the veterinary infrastructure, bolster the real-time monitoring of FMD, as well as a detailed investigation and documentation of every case of vaccination failure are provided with the goal of refining the control program.
Emma Goldman (1983)

American anarchist, 1869–1940, who founded and edited the journal Mother Earth. Skeptical about the suffrage movement, active in the campaign for birth control, a feminist and rebel, she was deported with other anarchists to Russia where she became disenchanted with the Soviet experiment.
Identification of a 13 Amino Acid Peptide Mimetic of Erythropoietin and Description of Amino Acids Critical for the Mimetic Activity of EMP1 (1998)

To obtain information about the functional importance of amino acids required for effective erythropoietin (EPO) mimetic action, the conserved residues of a peptide mimetic of EPO, recently discovered by phage display, were subjected to an alanine replacement strategy. Further, to identify a minimal mimetic peptide sequence, a series of truncation peptides has been generated. One EPO mimetic peptide sequence, EMP1, was targeted and more than 25 derivatives of this sequence were evaluated for their ability to compete with [125I]EPO for receptor binding and for their ability to support the proliferation of two EPO-responsive cell lines. Two hydrophobic amino acids, Tyr4 and Trp13, appear essential for mimetic action, and aromatic residues appear to be important at these sites. These findings are consistent with the previously reported X-ray crystal structure of EMP1 complexed with the extracellular domain of the EPO receptor (EPO binding protein; EBP). In our efforts to define the structural elements required for EPO mimetic action, a 13 amino acid peptide was identified which possesses mimetic properties and contains a minimal agonist epitope. The ability of this peptide to effectively serve as a mimetic capable of the induction of EPO-responsive cell proliferation appears to reside within a single residue, equivalent to position Tyr4 of EMP1, when present in a sequence that includes the cyclic core peptide structure. Although these peptides are less potent than EPO, they should serve as an excellent starting point for the design of compounds with EPO mimetic activity.
Efficient Storage of XML Data (2005)

We introduce NATIX, an efficient, native repository for storing, retrieving and managing tree-structured large objects, preferably XML documents. In contrast to traditionallarge object (LOB) managers, we do not split at arbitrary byte positions but take the semantics of the underlying tree structure of XML documents into account. Our parameterizable split algorithm dynamically maintains physical records of size smaller than a page which contain sets of connected tree nodes. This not only improves efficiency by clustering subtrees but also facilitates their compact representation. Existing approaches to store XML documents either use flat files or map every single tree node onto a separate physical record. The increased flexibility of our approach results in higher efficiency. Performance measurements validate this claim.
The role mining problem (2007)

Devising a complete and correct of roles has been recognized as one of the most important and challenging tasks in implementing role based access control. A key related to this is the notion of goodness/interestingness -- when is a role good/interesting? In this paper, we define the role mining (RMP) as the of discovering an optimal of roles from existing user permissions. The main contribution of this paper is to formally define RMP, and analyze its theoretical bounds. In addition to the above basic RMP, we introduce two different variations of the RMP, called the δ-approx RMP and the Minimal Noise RMP that have pragmatic implications. We reduce the known set basis problem to RMP to show that RMP is an NP-complete problem. An important contribution of this paper is also to show the relation of the role mining to several problems already identified in the data mining and data analysis literature. By showing that the RMP is in essence reducible to these known problems, we can directly borrow the existing implementation solutions and guide further research in this direction.
Single-beam two-photon-recorded monolithic multilayer optical disks (2000)

Monolithic multi-layer optical disks have been recorded with single-beam two-photon absorption using a high-repetition- rate laser. The recorded bit shape and signal readout will be discussed. It will also present some initial experimental results in cross talk and signal quality measurements.
Molecular Architecture and Evolution of a Modular Spider Silk Protein Gene (2000)

Spider flagelliform silk is one of the most elastic natural materials known. Extensive sequencing of spider silk genes has shown that the exons and introns of the flagelliform gene underwent intragenic concerted evolution. The intron sequences are more homogenized within a species than are the exons. This pattern can be explained by extreme mutation and recombination pressures on the internally repetitive exons. The iterated sequences within exons encode protein structures that are critical to the function of silks. Therefore, attributes that make silks exceptional biomaterials may also hinder the fixation of optimally adapted protein sequences.
Fluorescence Polarization in Homogeneous Nucleic Acid Analysis (1999)

A new method for DNA diagnostics based on template-directed primer extension and detection by fluorescence polarization is described. In this method, amplified genomic DNA containing a polymorphic locus is incubated with oligonucleotide primers (designed to hybridize to the DNA template adjacent to the polymorphic site) in the presence of allele-specific dye-labeled dideoxyribonucleoside triphosphates and a commercially available modified Taq DNA polymerase. The primer is extended by the dye-terminator specific for the allele present on the template, increasing approximately 10-fold the molecular weight of the fluorophore. At the end of the reaction, the fluorescence polarization of the two dye-terminators in the reaction mixture are analyzed directly without separation or purification. This homogeneous DNA diagnostic method is shown to be highly sensitive and specific and is suitable for automated genotyping of large number of samples. [The data shown in Figure 3 are available as an online supplement at.]
An ethanologenic yeast exhibiting unusual metabolism in the fermentation of lignocellulosic hexose sugars (2004)

Three lignocellulosic substrate mixtures [liquid fraction of acid-catalyzed steam-exploded softwood, softwood spent sulfite liquor (SSL) and hardwood SSL] were separately fermented by the industrially employed SSL-adapted strain Tembec T1 and a natural galactose-assimilating isolate (Y-1528) of Saccharomyces cerevisiae to compare fermentative efficacy. Both strains were confirmed as S. cerevisiae via molecular genotyping. The performance of strain Y-1528 exceeded that of Tembec T1 on all three substrate mixtures, with complete hexose sugar consumption ranging from 10 to 18 h for Y-1528, vs 24 to 28 h for T1. Furthermore, Y-1528 consumed galactose prior to glucose and mannose, in contrast to Tembec T1, which exhibited catabolite repression of galactose metabolism. Ethanol yields were comparable regardless of the substrate utilized. Strains T1 and Y-1528 were also combined in mixed culture to determine the effects of integrating their distinct metabolic capabilities during defined hexose sugar and SSL fermentations. Sugar consumption in the defined mixture was accelerated, with complete exhaustion of hexose sugars occurring in just over 6 h. Galactose was consumed first, followed by glucose and mannose. Ethanol yields were slightly reduced relative to pure cultures of Y-1528, but normal growth kinetics was not impeded. Sugar consumption in the SSLs was also accelerated, with complete utilization of softwood- and hardwood-derived hexose sugars occurring in 6 and 8 h, respectively. Catabolite repression was absent in both SSL fermentations.
Identification of Putative Gene Based Markers of Renal Toxicity (2004)

Renal toxicity commonly occurs after administration of xenobiotics and a variety of pharmaceutical agents.The process is typically initiated by a toxic injury to tubular epithelial cells in various nephron segments or by injury to specific cell types in the glomerulus.The initial injury is often followed by cellular proliferation and repair that attempts to restore normal renal function (Toback 1992).Changes in the expression of mRNA specifically expressed in the injured kidney cells are some of the earliest events that accompany renal injury.This is accompanied by changes in the expression of other genes that contribute either to cellular repair or recovery of renal function or in those that mediate fibrosis and further pathology of the kidney (Matejka 1998;Norman et al. 1988;Safirstein et al. 1990).For example, elevations in the expression of heme oxygenase I (HO-1), kidney injury molecule-1 (KIM-1), clusterin, thymosin beta 4, osteopontin, and several growth factors have been reported in various models of renal injury (Hammerman 1998a(Hammerman , 1998b;;
Molecular basis of Salmonella‐induced enteritis (2000)

Salmonella pathogenesis is a complex and multifactorial phenomenon. Many genes required for full virulence in mice have been identified, but only a few of these have been shown to be necessary for the induction of enteritis. Likewise, at least some of the Salmonella virulence factors affecting enteritis do not appear to be required for infection of systemic sites in mice. This suggests that subsets of virulence genes influence distinct aspects of Salmonella pathogenesis. Recently, considerable progress has been made in characterizing the virulence mechanisms influencing enteritis caused by non-typhoid Salmonella spp. The Salmonella pathogenicity island-1-encoded type III secretion system mediates the translocation of secreted effector proteins into target epithelial cells. These effector proteins are key virulence factors required for Salmonella intestinal invasion and the induction of fluid secretion and inflammatory responses.
DLA-IDENTICAL MARROW GRAFTS AFTER LOW-DOSE TOTAL-BODY IRRADIATION (1995)

Storb, Rainer; Raff, Robert F.; Deeg, H Joachim; Graham, Theodore C.; Schuening, Friedrich G.; Shulman, Howard; Bryant, Eileen Author Information
Using Extensions to World System Teletext (1985)

World System Teletext is now well established as a reliable and economical information service in the consumer environment. Over seven million teletext decoders are now in use in various parts of the world, using the basic teletext transmissions which have been in service since 1976.
Altered Interaction Between PSD‐95 and the NMDA Receptor Following Transient Global Ischemia (2000)

The postsynaptic density (PSD) is a cytoskeletal specialization involved in the anchoring of neurotransmitter receptors and in regulating the response of postsynaptic neurons to synaptic stimulation. The postsynaptic protein PSD-95 binds to NMDA receptor subunits NR2A and NR2B and to signaling molecules such as neuronal nitric oxide synthase and p135synGAP. We investigated the effects of transient cerebral ischemia on protein interactions involving PSD-95 and the NMDA receptor in the rat hippocampus. Ischemia followed by reperfusion resulted in a decrease in the solubility of the NMDA receptor and PSD-95 in 1% sodium deoxycholate, the decrease being greater in the vulnerable CA1 hippocampal subfield than in the less sensitive CA3/dentate gyrus regions. Solubilization of the kainic acid receptor GluR6/7 and the PSD-95 binding proteins, neuronal nitric oxide synthase and p135synGAP, also decreased following ischemia. The association between PSD-95 and NR2A and NR2B, as indicated by coimmunoprecipitation, was less in postischemic samples than in sham-operated controls. Ischemia also resulted in a decrease in the size of protein complexes containing PSD-95, but had only a small effect on the size distribution of complexes containing the NMDA receptor. The results indicate that molecular interactions involving PSD-95 and the NMDA receptor are modified by an ischemic challenge.
Reconfigurable add-drop multiplexer for spatial modes (2013)

We show how a spatial mode can be extracted from a light beam, leaving the other orthogonal modes undisturbed, and allowing a new signal to be retransmitted on that mode. The method is self-aligning, avoids fundamental splitting losses, and uses only local feedback loops on controllable beam splitters and phase shifters. It could be implemented with Mach-Zehnder interferometers in planar optics. The method can be extended to multiple simultaneous mode extractions. As a spatial reconfigurable optical add-drop multiplexer, it is hitless, allowing reconfiguration without interrupting the transmission of any channel.
Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of P-selectin (1996)

Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. We examined the cardioprotective effects of N,N,N-trimethylsphingosine (TMS) in a murine model of MI (20 min) and R (24 h) injury in vivo, focusing on leukocyte-endothelial interactions. TMS is a synthetic N-methylated sphingosine derivative that has protein kinase C inhibitory activity and has been shown to prevent leukocyte activation. TMS (18 microgram/kg), administered intravenously 1 min prior to reperfusion, significantly attenuated myocardial necrotic injury assessed by myocardial creatine kinase loss compared with MI/R rats receiving only vehicle (P<0.001). Cardiac myeloperoxidase activity, an index of PMN accumulation in the ischemic myocardium, was also significantly attenuated by TMS compared with rats receiving vehicle (P<0.001). We further examined whether TMS can attenuate leukocyte-endothelial interaction by intravital microscopy. TMS significantly attenuated NG-nitro-L-arginine-methyl ester (L-NAME)-stimulated PMN rolling and adherence to the rat microvascular endothelium. This action of TMS appears to be mediated by reduction of P-selectin expression because immunohistochemical analysis demonstrated that TMS significantly attenuated endothelial P-selectin expression in the L-NAME-superfused rat mesenteric microvasculature. Similarly, TMS markedly attenuated rapid P-selectin expression in rat platelets stimulated with either thrombin or L-NAME assessed by flow cytometry. In conclusion, TMS seems to be an effective cardioprotective agent by inhibiting early leukocyte-endothelial interaction, thus preventing leukocyte accumulation in the ischemic reperfused myocardium.
Elastic imaging and time-lapse migration based on adjoint methods (2009)

Abstract We have drawn connections between imaging in exploration seismology, adjoint methods, and emerging finite-frequency tomography. All of these techniques rely on spatial and temporal constructive interference between observed and simulated waveforms to map locations of structural anomalies. Modern numerical methods and computers have facilitated the accurate and efficient simulation of 3D acoustic, (an)elastic, and poroelastic wave propagation. Using a 2D cross section of the SEG/EAGE salt model, we have determined how such waveform simulations might be harnessed to improve onshore and offshore seismic imaging strategies and capabilities. We have found that the density sensitivity kernel in adjoint tomography is related closely to the imaging principle in exploration seismology, and that in elastic modeling the impedance kernel actually is a better diagnostic tool for reflector identification. The shear- and compressional-wave speed sensitivity kernels in adjoint tomography are related closely to finite-frequency banana-doughnut kernels, and these kernels are well suited for mapping larger-scale structure, i.e., for transmission tomography. These ideas have been substantiated by addressing problems in subsalt time-lapse migration.
Superoxide dismutase in psoriasis, squamous cell carcinoma and basal cell epithelioma: an immunohistochemical study (1991)

Monoclonal antibodies against human Cu,Zn-superoxide dismutase (SOD) and Mn-SOD were used to stain frozen sections of normal and abnormal human skin. In normal human epidermis, the Cu,Zn-SOD antibody almost exclusively stained the basal cells. Mn-SOD antibody weakly stained the whole of the epidermis but more predominantly the basal cell layer. In psoriasis, Cu,Zn-SOD antibody mainly stained the basal cells of the lowest parts of the elongated rete ridges. Basal cells corresponding to the tip of the dermal papillae were weakly stained. Mn-SOD staining was considerably decreased in the psoriatic epidermis. In squamous cell carcinoma, staining with both Cu,Zn-SOD and Mn-SOD antibodies was decreased, and single cells positive for Cu,Zn-SOD were scattered throughout the tumour nests. In basal cell epithelioma, Cu,Zn-SOD staining was intense and diffusely distributed throughout the tumour nests, while Mn-SOD staining was absent.