gebhart/patrepeval huggingface dataset:
Conocimientos y prácticas asociadas al derecho de autor en profesionales de la información de la red de bibliotecas médicas. (2011)

Con el objetivo de diagnosticar los conocimientos y practicas asociadas al derecho de autor de los profesionales de la informacion de los Institutos y Centros de Investigacion de la red de salud de Ciudad de La Habana se realizo un estudio descriptivo d urante el periodo marzo-junio del 2010. Se aplico un cuestionario a profesionales de la informacion de 12 Institutos y 12 Centros de Investigacion, se realizo un grupo focal y una entrevista. Se identificaron los conocimientos sobre terminos, relaciones e implicaciones del derecho de autor, asi como la correspondencia entre sus conocimientos y practicas profesionales en los procesos de Desarrollo de Colecciones, Diseno de Productos, Prestacion de Servicios y la Alfabetizacion informacional. Se destacan como principales resultados del estudio e l bajo nivel de conocimiento de los profesionales sobre los terminos, contenidos y legislaciones del derecho de autor, la aplicacion de algunas nociones con mayor frecuencia durante la Alfabetizacion Informacional y el Desarrollo de Colecciones, asi como el reconocimiento por parte de los involucrados en el estudio de sus debilidades y la necesidad de superarlas.
AAP targets health reform improvements (1994)

Aiming to enhance pediatric-specific provisions in President Clinton9s health care reform bill, the AAP Board of Directors targeted 10 areas for improvements and outlined strategies for addressing them during a January AAP standing board committee meeting. AAP officials say the 10 areas encompass issues not adequately addressed by the president9s bill, called Health Security Act (HSA), which was introduced last November. The Academy, noting improvements were needed, issued qualified support for the bill in December.
Electrostatic potential for a hyperbolic probe tip near a semiconductor (2003)

The electrostatic potential resulting from a metallic probe tip near a semiconductor is examined. A solution is formulated assuming circular symmetry and using prolate spheroidal coordinates in the vacuum and Cartesian coordinates in the semiconductor. The result is most directly applied to the case of a hyperbolic probe tip, but other shapes (for example, a small hemispherical protrusion on the tip apex) can also be handled. Numerical results are given for representative cases that might be encountered in scanning probe microscopy.
Investigations into the feasibility of multiple input multiple output techniques within the HF band: Preliminary results (2009)

The concept of multiple input multiple output (MIMO) has become a productive area of research in the field of wireless communications with the aim of delivering increased data throughput. However, to date, MIMO research has focused primarily on short‐range communications within the VHF, UHF, and SHF bands, and very little research has been conducted toward exploiting MIMO techniques for long‐range communications within the HF band. Between September 2007 and September 2008, several experimental campaigns were conducted to investigate the feasibility of applying MIMO techniques within the HF band. The results of measurements over a 255 km path from Durham to Leicester within the United Kingdom are presented in this paper with particular emphasis on the use of heterogeneous antenna arrays at the transmitter and receiver.
Experimental and Numerical Investigation of Curve Section Stringer/skin Runout Under Tensile Load (2019)

Experiment and numerical model were conducted to understand mechanical property and failure mechanism of T800/HT-280 composite stringer/skin runout structure under tensile load. The debonding initiation load is 31. 68kN and interlayer failed at the load of 51.18kN. The debonding starts at the center of runout tip and is dominated by mode II fracture. Besides, mechanical properties of stringer with curve and slash section are analyzed with numerical models. The curve section stringer/skin structure can postpone damage initiation but accelerate damage spread compared to the slash, which can be explained by severely change of stiffness.
Activation of Meningeal Nociceptors by Cortical Spreading Depression: Implications for Migraine with Aura (2010)

Attacks of migraine with aura represent a phenomenon in which abnormal neuronal activity in the cortex produces sensory disturbances (aura) some 20-40 min before the onset of headache. The purpose of this study was to determine whether cortical spreading depression (CSD)--an event believed to underlie visual aura--can give rise to activation of nociceptors that innervate the meninges--an event believed to set off migraine headache. CSD was induced in anesthetized male rats by stimulation of the visual cortex with electrical pulses, pin prick, or KCl; single-unit activity of meningeal nociceptors was monitored in vivo in the rat before and after CSD. Regardless of the method of cortical stimulation, induction of CSD was recorded in 64 trials. In 31 of those trials, CSD induced a twofold increase in meningeal nociceptor firing rate that persisted for 37.0 +/- 4.6 min in trials in which activity returned to baseline, or >68 min in trials in which activity remained heightened at the time recording was interrupted. In two-thirds of the trials, onset of long-lasting neuronal activation began approximately 14 min after the wave of CSD. The findings demonstrates for the first time that induction of CSD by focal stimulation of the rat visual cortex can lead to long-lasting activation of nociceptors that innervate the meninges. We suggest that migraine with aura is initiated by waves of CSD that lead up to delayed activation of the trigeminovascular pathway.
Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′-Dichlorofluorescin (1990)

Hydroethidine (HE) and 2',7'-dichlorofluorescin (DCFH) were used for the flow cytometric measurement of reactive oxygen metabolites in leukocytes. Hydroethidine and DCFH were both rapidly oxidized in a cell-free cuvette assay to ethidium bromide (EB) and 2',7'-dichlorofluorescein (DCF) by H2O2 and peroxidase, but not by H2O2 alone, while only HE was oxidized by KO2, a source of O2-. Quiescent lymphocytes, monocytes, and neutrophils spontaneously oxidized HE to EB, while DCFH was only oxidized to a low degree. Neutrophils increased 6.9-fold in EB red fluorescence and 12.5-fold in DCF green fluorescence during the respiratory burst induced by phorbol 12-myristate 13-acetate or 6.1-fold and 4.7-fold, respectively, during the respiratory burst induced by Escherichia coli bacteria. The HE or DCFH oxidation during the respiratory burst, unlike the spontaneous HE oxidation, was not inhibitable by 10 mM NaNe indicating a non-mitochondrial source of cellular oxidants during the respiratory burst such as NADPH oxidase, which produces O2-. The oxidation of DCFH, but not of HE, was decreased in stimulated neutrophils, which were simultaneously loaded with HE and DCFH. Intracellular DCFH oxidation induced by incubation of resting neutrophils with extracellular H2O2 was not influenced by the presence of HE. This indicates that HE is oxidized at an earlier step in the reactive oxygen metabolism of neutrophils than DCFH, i.e., by early oxygen metabolites like O2-, while DCFH is oxidized in part by H2O2 and phagosomal peroxidases. The differential oxidation of HE and DCFH during simultaneous cellular staining permits the analysis of up to three functionally different neutrophil populations in septic patients. This is of interest for the determination of disease-related alterations of oxygen metabolism in quiescent and stimulated leukocytes.
Short-term, high-efficiency expression of transfected DNA. (1984)

We have achieved high-efficiency uptake and expression of foreign DNA in mouse Ltk- cells by modifying the DEAE-dextran-mediated transfection method of McCutchan and Pagano (J. Natl. Cancer Inst. 42:351-357, 1968) to include an initial incubation at elevated pH followed by a shock treatment with dimethyl sulfoxide. Up to 80% of mouse Ltk- cells transfected with the herpes simplex virus thymidine kinase gene expressed thymidine kinase as measured by autoradiography.
Measurement of the Dielectric Properties of Biological Substances Using an Improved Open-Ended Coaxial Line Resonator Method (1987)

An improved open-ended coaxial line resonator method for measuring the complex permittivity of biological substances is presented. By considering the end radiation losses and higher order mode effects, the upper frequency limit is extended from 4 GHz to 11 GHz. A novel lambda/4 open-ended coaxial line resonator, which uses a thin copper diaphragm for a coupling structure, was developed. Experiments show that the structure is very flexible, convenient, and reliable. Experimental results for several canine organs as well as human skin are given. The method has useful applications to microwave medicine and bioelectromagnetic studies.
Light directed massively parallel on‐chip synthesis of peptide arrays with t‐Boc chemistry (2003)

Peptide and peptidomimetic molecule arrays are emerging powerful tools for parallel screening of binding in proteomics and pharmaceutical discovery research. Up to now the common method of preparing peptide arrays was based on spotting on glass using a library of presynthesized peptides. However, due to the large number of monomers (amino acids) it is not possible to have combinatorial libraries which include all combinations of natural and synthetic amino acids. We describe a very flexible on-chip oligopeptide synthesis method which uses the well developed t-Boc based solid state synthesis chemistry. A very high degree of flexibility is achieved by using light photo generated acids and maskless projection lithography for spatially directed deprotection. Use of microfluidic chips enables moderately high densities, short reaction times and off-the-shelf chemicals. Examples are given from synthesis of metal ion binding peptides and epitope binding assays.
Lipidic Implants for Pharmaceutical Proteins (2007)

Winter for the possibility to join his research group.Especially, I
Engineering Antibodies for Therapy (2002)

With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, optimally biodistributed antibody fragments, especially for solid tumors. The latest developments in engineering antibodies for removal or enhancement of effector functions (antibody-dependent cellular cytotoxicity (ADCC), phagosytosis, complement fixation (CDC) and half-life) through protein alteration or carbohydrate optimization may now enable generation of superior antibody therapeutics. Antibody conjugates, including immunotoxins and immunocytokines, as well as multivalent and multispecific antibodies confer expanded utility of therapeutic antibodies. Finally, research into the IgA/FcalphaRI system has now provided an additional route to therapeutic antibodies.
Single-beam three-axis atomic magnetometer (2016)

A single-beam atomic magnetometer being operated near zero-field and measuring three-axis fields simultaneously is demonstrated. We produce a rotating field on the x-0-y plane with the frequency of 90 Hz and a modulation field in the z axis at 130 Hz. The rotating field enables a nonzero z axis output when the transverse fields are zeroed using feedback systems. Based on the phase difference of π/2, x and y axes fields can be measured using one lock-in amplifier. Magnetic field sensitivities of 300 fT/Hz1∕2 in x and y axes and 3 pT/Hz1∕2 in the z axis are achieved.
Phase II trial of 177Lutetium radiolabeled anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 (177Lu- J591) in patients (pts) with metastatic androgen-independent prostate cancer (AIPC) (2007)

15523 Background: A phase 1 trial of 177Lu-J591 in pts with metastatic AIPC demonstrated acceptable toxicity, excellent targeting of metastatic sites and biologic activity. Methods: Pts with progressive, metastatic AIPC receive one dose of 177Lu-J591 in two- cohorts: cohort 1 (65 mCi/m 2 ), 15 pts; cohort 2: (70 mCi/m 2 ), 17 pts. The primary endpoint is PSA and/or measurable disease response; secondary endpoint is toxicity. A 177Lu-J591 imaging study is done to confirm tumor targeting. Results: 21 pts (8 chemo-naive), median age 73, have been treated to date, 15 in cohort 1, 6 in cohort 2. Two pts with bone-only metastases achieved PSA declines of &gt;50%. One had an 87% PSA decline lasting 126 days with resolution of bone pain. A 2nd pt has a PSA decline of 58% that continues without progression at 6 mo post-rx. PSA stabilization (&lt;25% PSA rise above baseline) occurred in an additional 9 pts (43%), 7 through wk 8 (1 of whom is still under follow-up) and 2 pts through wk 12. Of 7 pts with measurable disease, 6 have had post-rx CT scans completed, 3 were stable, 3 progressed. In these pts with measurable disease, PSA was more likely to diagnose progression, with only 1 stable and 5 progressed by PSA criteria. Platelet nadir &lt;20 x 10e9/L occurred in 6 pts, 3 of whom required platelet transfusions (mean = 2). 17/19 evaluable pts recovered normal platelet counts; the remaining 2 pts had rapidly progressive disease, 1 of whom had biopsy confirmed marrow replacement by tumor. Neutropenia &lt;/= 0.5 x 10e9/L occurred in 4 pts, 2 of whom received brief rx with growth factors. All 19 evaluable pts had normal neutrophil recovery. No significant drug-related non-hematologic toxicity has occurred. Targeting of known sites of PC metastases has been observed in all pts. Conclusions: Single dose 177Lu-J591 demonstrates anti-tumor activity in pts with progressive, metastatic AIPC with reversible myelosuppression. Accrual is continuing. [Table: see text]
Photocleavable aminotag phosphoramidites for 5'-termini DNA/RNA labeling (1998)

We report the design and evaluation of two non-nucleosidic photocleavable aminotag phosphor-amidites. These reagents introduce a photocleavable amino group on the 5'-terminal phosphate of synthetic oligonucleotides. The 5' photocleavable amino group enables introduction of a variety of amine-reactive markers onto synthetic oligonucleotides as well as immobilization on activated solid supports. The photocleavable bond on the 5'-phosphate can then be selectively cleaved by near-UV illumination, thereby enabling release of the marker or detachment of the oligonucleotide from a solid support. The preparation of photocleavable conjugates with biotin, digoxigenin and tetramethylrhodamine are described. In the case of biotin, a conjugate was used in a high sensitivity hybridization assay as a photocleavable probe for a complementary sequence immobilized on beads. It is also demonstrated that the 5'-PC-amino group can be used as an affinity tag for photocleavage-mediated affinity purification and phosphorylation of synthetic oligonucleotides in conjunction with activated supports. Such 5'-PC-amino labeled oligonucleotides should be useful in a variety of applications in molecular biology including multiple non-radioactive probing of DNA/RNA blots, affinity isolation and purification of nucleic acids binding proteins, diagnostic assays requiring release of the probe-target complex or specific marker, cassette mutagenesis and PCR. They will also enable the spatially-addressable photorelease of the probe-target complexes or marker molecules for diagnostic purposes.
Applications of Nonlinear Dynamics to Clinical Cardiologya (1987)

(1) Nonlinear mechanisms may apply both to the understanding of SA-AV node interactions and to bifurcations leading to certain types of AV block. (2) The fractal His-Purkinje system serves as the structural substrate for the generation of the broadband, inverse power-law spectrum of the stable ventricular depolarization (QRS) waveform. (3) Fractal anatomy is also seen in multiple other systems: pulmonary, hepatobiliary, renal, etc. Fractal morphogenesis may reflect a type of critical phenomenon that results in the generation of these irregular, but self-similar structures. (4) Self-similar (fractal) scaling may underlie the 1/f-like spectra seen in multiple systems (e.g., interbeat interval variability, daily neutrophil fluctuations). This fractal scaling may provide a mechanism for the "constrained randomness" that appears to underlie physiological variability and adaptability. (5) Behavior consistent with subharmonic bifurcations is seen in cardiac electrophysiology (e.g., sick sinus syndrome) and hemodynamic perturbations (e.g., swinging heart phenomenon in pericardial tamponade). (6) Ventricular tachyarrhythmias associated with sudden cardiac death (e.g., torsades de pointes, ventricular fibrillation) appear to reflect relatively periodic, not chaotic (turbulent) processes resulting from disruption of the physiologic fractal depolarization sequence. (7) Spectral analysis of Holter monitor data may help in the detection of patients at high risk for sudden death.
Stencil computation optimization and auto-tuning on state-of-the-art multicore architectures (2008)

Understanding the most efficient design and utilization of emerging multicore systems is one of the most challenging questions faced by the mainstream and scientific computing industries in several decades. Our work explores multicore stencil (nearest-neighbor) computations - a class of algorithms at the heart of many structured grid codes, including PDE solvers. We develop a number of effective optimization strategies, and build an auto-tuning environment that searches over our optimizations and their parameters to minimize runtime, while maximizing performance portability. To evaluate the effectiveness of these strategies we explore the broadest set of multicore architectures in the current HPC literature, including the Intel Clovertown, AMD Barcelona, Sun Victoria Falls, IBM QS22 PowerXCell 8i, and NVIDIA GTX280. Overall, our auto-tuning optimization methodology results in the fastest multicore stencil performance to date. Finally, we present several key insights into the architectural tradeoffs of emerging multicore designs and their implications on scientific algorithm development.
IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ (2000)

IL-18 shares with IL-1 the same family of receptors and several identical signal transduction pathways. Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammatory property of IL-1. IL-18 was highly active in PBMC by inducing the synthesis of the chemokine IL-8; however, no induction of PGE(2) synthesis nor cyclooxygenase type-2 gene expression was observed in PBMC stimulated with IL-18. In the same cultures, IL-1beta induced a 12-fold increase in PGE(2). Although IL-1beta-induced IL-8 synthesis was augmented 3-fold by IL-18, IL-18 suppressed IL-1beta-induced PGE(2) production by 40%. The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2). Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta-induced IFN-gamma but suppressed IL-1beta-induced PGE(2) by 75%. IL-18 binding protein (IL-18BP) is a naturally occurring and specific inhibitor of IL-18. When recombinant IL-18BP was added to PBMC cultures, unexpectedly, spontaneous PGE(2) production increased. PGE(2) production was also increased by the addition of IL-18BP to PBMC stimulated with either IL-1beta or IL-12 and also in whole blood cultures stimulated with Staphylococcus epidermidis. These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses.
Biochemical Demonstration of the Involvement of Fatty Acyl-CoA Synthetase in Fatty Acid Translocation across the Plasma Membrane (2004)

Fatty acyl-CoA synthetase, the first enzyme of the beta-oxidation pathway, has been proposed to be involved in long chain fatty acid translocation across the plasma membrane of prokaryotic and eukaryotic cells. To test this proposal, we used an in vitro system consisting of Escherichia coli inner (plasma) membrane vesicles containing differing amounts of trapped fatty acyl-CoA synthetase and its substrates CoA and ATP. This system allowed us to investigate the involvement of fatty acyl-CoA synthetase independently of other proteins that are involved in fatty acid translocation across the outer membrane and in downstream steps in beta-oxidation, because these proteins are not retained in the inner membrane vesicles. Fatty acid uptake in vesicles containing fatty acyl-CoA synthetase was dependent on the amount of exogenous ATP and CoASH trapped by freeze-thawing. The uptake of fatty acid in the presence of non-limiting amounts of ATP and CoASH was dependent on the amount of endogenous fatty acyl-CoA synthetase either retained within vesicles during isolation or trapped within vesicles after isolation by freeze-thawing. Moreover, the fatty acid taken up by the vesicles was converted to fatty acyl-CoA. These data are consistent with the proposal that fatty acyl-CoA synthetase facilitates long chain fatty acid permeation of the inner membrane by a vectorial thioesterification mechanism.
Dual-band antenna for hand held portable telephones (1996)

A novel planar dual-band inverted F-antenna for hand held portable telephones has been realised to operate at 0.9 and 1.8 GHz bands. The dual-band antenna is almost the same size as a conventional inverted F-antenna operating at 0.9 GHz, and has an isolation between bands of better than 17 dB.
Striking the Balance (2006)

January 01 2006 Striking the Balance Robert J. Art Robert J. Art Waltham, Massachusetts Search for other works by this author on: This Site Google Scholar Author and Article Information Robert J. Art Waltham, Massachusetts Online Issn: 1531-4804 Print Issn: 0162-2889 © 2006 by the President and Fellows of Harvard College and the Massachusetts Institute of Technology.2006 International Security (2006) 30 (3): 177–185. https://doi.org/10.1162/isec.2005.30.3.177 Cite Icon Cite Permissions Share Icon Share Twitter LinkedIn Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Search Site Citation Robert J. Art; Striking the Balance. International Security 2006; 30 (3): 177–185. doi: https://doi.org/10.1162/isec.2005.30.3.177 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsInternational Security Search Advanced Search This content is only available as a PDF. © 2006 by the President and Fellows of Harvard College and the Massachusetts Institute of Technology.2006 Article PDF first page preview Close Modal You do not currently have access to this content.
A fast route for application of rate-distortion optimal quantization in an MPEG video encoder (2002)

The freedom which is offered by the adaptable MPEG video encoders is meaningfully exploited by means of a "rate-distortion optimal" framework using a Lagrange formalism, as is well known from the literature. One such feature of interest is "optimal quantization". We propose some practical short-cut solutions, which reduce the computational complexity typically associated with "rate-distortion optimal" coding. The Lagrange multiplier, which is the most important parameter controlling the encoding of a single picture, is successfully predicted on the basis of a set of histograms for the amplitude distribution of each DCT-coefficient. In combination with a block-based bit-rate control the selection of the optimal quantizer step-size is further simplified.