gebhart/patrepeval huggingface dataset:
A novel procedure for the cleavage of olefin derivatives to aldehydes using potassium permanganate (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel procedure for the cleavage of olefin derivatives to aldehydes using potassium permanganatePeter Viski, Zoltan Szeverenyi, and Laszlo I. SimandiCite this: J. Org. Chem. 1986, 51, 16, 3213–3214Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00366a029https://doi.org/10.1021/jo00366a029research-articleACS PublicationsRequest reuse permissionsArticle Views1302Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proofs of Retrievability: Theory and Implementation. (2008)

A proof of retrievability (POR) is a compact proof by a file system (prover) to a client (verifier) that a target file F is intact, in the sense that the client can fully recover it. As PORs incur lower communication complexity than transmission of F itself, they are an attractive building block for high-assurance remote storage systems. In this paper, we propose a theoretical framework for the design of PORs. Our framework improves the previously proposed POR constructions of Juels-Kaliski and Shacham-Waters, and also sheds light on the conceptual limitations of previous theoretical models for PORs. It supports a fully Byzantine adversarial model, carrying only the restriction—fundamental to all PORs—that the adversary’s error rate 2 be bounded when the client seeks to extract F . Our techniques support efficient protocols across the full possible range of 2, up to 2 non-negligibly close to 1. We propose a new variant on the Juels-Kaliski protocol and describe a prototype implementation. We demonstrate practical encoding even for files F whose size exceeds that of client main memory.
学生、家长、学校：三点一线 (2006)

没人能够准确说明学生、家长与学校之间的恰当关系。多年来法律一直试图界定谁应对学生的行为承担责任和义务，问题由社会文化变革引起，同时涵盖社会文化的变革。目前最为突出的变化是家长不断干涉并介入孩子的学习和生活，此外也有法律上的变更，而高校在满足家长的期望和管理学生方面也进行了多方面的努力。
Comparison of 7 Methods for Extracting Cell-Free DNA from Serum Samples of Colorectal Cancer Patients (2009)

The presence of cell-free DNA of tumor origin in serum or plasma of cancer patients (1) has triggered numerous studies to explore the diagnostic and prognostic potential of circulating DNA. This DNA, present only in minute concentrations in plasma or serum, is highly fragmented (2), a condition that often leads to substantial loss of DNA of small sizes in the course of DNA isolation. The lack of consensus regarding which extraction method is better for the efficient capture of such DNA might be partially responsible for the large disparities in the literature, which are reflected in reports of total concentrations of plasma or serum DNA alone (3) or DNA integrity measurement as a diagnostic or prognostic tool. The ability to detect mutated v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog ( KRAS ) DNA in serum has been reported to vary with the chosen DNA isolation methods (4).

We evaluated in parallel 7 isolation approaches (Table 1⇓ ) by extracting cell-free DNA from 12 pooled sera obtained from 67 colorectal cancer patients and grouped on the basis of TNM tumor staging [tumor extent (T), spread to lymph nodes (N), and metastasis (M)].1 The approaches we evaluated involved diverse strategies for DNA isolation. The experimental set-up involved DNA isolation from a 2-mL aliquot of serum in duplicate followed by DNA quantification by the fluorescent Quant-iT dsDNA HS assay (Invitrogen) and a Taqman real-time PCR (rPCR) technique on the cadherin 1, type 1, E-cadherin (epithelial) ( CDH1 ) gene. To exclude false results in the CDH1 amplification due to …
Elevated Levels of Chemokines in Esophageal Mucosa of Patients With Reflux Esophagitis (2003)

Chemokines play a key role in the pathogenesis of various inflammatory conditions. However, there is little information on their profile in reflux esophagitis (RE). We sought to study esophageal mucosa levels of chemokines in RE.A total of 32 outpatients with RE and 13 normal controls were studied. Endoscopic severity of RE was classified according to the Los Angeles grading system. Paired biopsy specimens were taken from the esophagus 3 cm above the gastroesophageal junction; one biopsy was snap frozen for measurement of mucosal levels of interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1), regulated on activation normal T-cell expressed and presumably secreted (RANTES), and IL-1 beta by enzyme linked immunosorbent assays, while the other was formalin-fixed for histopathological evaluation.IL-8, MCP-1, and RANTES levels were significantly higher in esophageal mucosa of RE patients than those of the controls. IL-8 levels correlated significantly with the endoscopic severity of RE. Basal zone hyperplasia and papillary elongation, histopathological hallmarks of RE, were both associated with higher levels of IL-8 and MCP-1. The presence of intraepithelial neutrophils and eosinophils, which also indicate RE, was associated with high levels of IL-8 and RANTES, respectively. There were no significant differences in IL-1 beta levels between the RE and control groups, but IL-1 beta levels correlated significantly with the IL-8 production. Again, the IL-8 levels were significantly decreased after lansoprazole treatment.Our results indicate that chemokines produced locally in the esophageal mucosa may be involved in the development and progression of RE.
Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts (2008)

AZD1152-HQPA- and ZM447439 are effective apoptosis-inducing agents in acute myeloid leukemia cell lines and primary acute myeloid leukemia cultures. However, their propensity to induce polyploidy does not inevitably result in apoptosis.
T-Independent Immune Response: New Aspects of B Cell Biology (2000)

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients (2015)

ABCA1 may be a tumor suppressor and is hypermethylated in a subset of ovarian cancer patients. Hypermethylation of ABCA1 is associated with poor prognosis in these patients.
Effective Melanoma Immunotherapy in Mice by the Skin-Depigmenting Agent Monobenzone and the Adjuvants Imiquimod and CpG (2010)

MIC therapy is effective in eradicating melanoma, by vigilantly incorporating NK-, B- and T cells in its therapeutic effect. Based on these results, the MIC regimen presents a high-yield, low-cost and simple therapy, readily applicable in the clinic.
Comparison of the stratum corneum thickness measured in vivo with confocal Raman spectroscopy and confocal reflectance microscopy (2013)

Both methods, CRS and CLSM, were found to be suitable to measure SC thickness correctly. Therefore, when using CRS, for example to obtain detailed information about the molecular composition of the skin, it is additionally possible to accurately measure SC thickness with the same device to have an orientation in which skin layer molecules are found.
Thermal comfort, productivity and energy consumption in the tropical office environment: a critical overview (2009)

Thermal comfort has developed along two distinct models: deterministic and adaptive. We investigate the validity of these models against the increasingly urgent call to reduce building energy consumption. The air-conditioned office, predicated on the deterministic thermal comfort model, expends about 50% of its energy on air-conditioning. In a resource-constrained world, while acknowledging the need for thermal comfort, the parameters of thermal comfort should be re-examined. This paper explores the potential for the adaptive thermal comfort model to provide acceptable levels of thermal comfort while reducing cooling demand in office buildings located in the tropics. It links thermal comfort and productivity with the persistence of air-conditioning in knowledge-based economies located in the tropics.
A Sub-Nyquist Rate Sampling Receiver Exploiting Compressive Sensing (2011)

This paper presents a sub-Nyquist rate sampling receiver architecture that exploits signal sparsity by employing compressive sensing (CS) techniques. The receiver serves as an analog-to-information conversion system that works at sampling rates much lower than the Nyquist rate. A parallel-path structure that employs current mode sampling techniques is used. The receiver performance is quantified analytically. Useful and fundamental design guidelines that are unique to CS are provided based on the analytical tools. Simulations with a 90-nm CMOS process verify the theoretical derivations and the circuit implementations. Based on these results, it is shown that an instantaneous receiver signal bandwidth of 1.5 GHz and a signal-to-noise-plus-distortion ratio of 44 dB are achievable. The receiver power consumption is estimated to be 120.8 mW. A comparison with state-of-the-art high-speed analog-to-digital conversions reveals that the proposed approach improves the figure of merit by a factor of three if the signal exhibits a 4% sparsity.
Lymphocyte Activation Gene-3 Fusion Protein Increases the Potency of a Granulocyte Macrophage Colony-Stimulating Factor–Secreting Tumor Cell Immunotherapy (2008)

LAG-3Ig combined with a GM-CSF-secreting tumor cell immunotherapy stimulated both cellular and humoral antitumor immune responses that correlated with prolonged survival in tumor-bearing animals.
Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study (1982)

The objective of the current study, initiated in 1976, was to improve upon the high relapse rate and subsequent mortality in children and young adults with acute nonlymphocytic leukemia (ANLL). Seventeen patients, ages 6--28, with ANLL in first bone marrow remission, received cyclophosphamide and total body irradiation using a radiation scheme of 750 rad (7.5 Gy) total dose, delivered at a dose rate of 26 rad (26 cGy) per minute. Allogeneic marrow from HLA-matched sibling donors was followed by prophylactic therapy or graft-versus-host disease (GVHD). Median follow-up of the entire group is 20+ mo; survivors have been followed for a minimum of 14+ mo. Interstitial pneumonitis was observed in 6% of patients, and GVHD was observed in 29%. Seventy percent of patients are alive and in complete continuous remission. Two patients have relapsed (at 7 and 24 mo). Actuarial relapse-free survival is 76% at 1 yr and 64% at 5 yr. Quality of life in this disease-free survivors is excellent; all patients are free of active GVHD, receive no maintenance chemotherapy, and have high Karnofsky performances scores. High dose rate total body irradiation plus cyclophosphamide followed by allogeneic BMT may provide an opportunity for long-term complication-free survival in a substantial proportion of children and young adults with ANLL.
Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells (2018)

We have developed a structure-based high-throughput screening (HTS) method, using time-resolved fluorescence resonance energy transfer (TR-FRET) that is sensitive to protein-protein interactions in living cells. The membrane protein complex between the cardiac sarcoplasmic reticulum Ca-ATPase (SERCA2a) and phospholamban (PLB), its Ca-dependent regulator, is a validated therapeutic target for reversing cardiac contractile dysfunction caused by aberrant calcium handling. However, efforts to develop compounds with SERCA2a-PLB specificity have yet to yield an effective drug. We co-expressed GFP-SERCA2a (donor) in the endoplasmic reticulum membrane of HEK293 cells with RFP-PLB (acceptor), and measured FRET using a fluorescence lifetime microplate reader. We screened a small-molecule library and identified 21 compounds (Hits) that changed FRET by >3SD. 10 of these Hits reproducibly alter SERCA2a-PLB structure and function. One compound increases SERCA2a calcium affinity in cardiac membranes but not in skeletal, suggesting that the compound is acting specifically on the SERCA2a-PLB complex, as needed for a drug to mitigate deficient calcium transport in heart failure. The excellent assay quality and correlation between structural and functional assays validate this method for large-scale HTS campaigns. This approach offers a powerful pathway to drug discovery for a wide range of protein-protein interaction targets that were previously considered "undruggable".
Chicken double-stranded RNA adenosine deaminase has apparent specificity for Z-DNA. (1995)

A M(r) 140,000 protein has been purified from chicken lungs to apparent homogeneity. The protein binds with high affinity to a non-BNA conformation, which is most likely to the Z-DNA. The protein also has a binding site for double-stranded RNA (dsRNA). Peptide sequences from this protein show similarity to dsRNA adenosine deaminase, an enzyme that deaminates adenosine in dsRNA to form inosine. Assays for this enzyme confirm that dsRNA adenosine deaminase activity and Z-DNA binding are properties of the same molecule. The coupling of these two activities in a single molecule may indicate a distinctive mechanism of gene regulation that is, in part, dependent on DNA topology. As such, DNA topology, through its effects on the efficiency and extent of RNA editing may be important in the generation of new phenotypes during evolution.
Folate-Liposome-Mediated Antisense Oligodeoxynucleotide Targeting to Cancer Cells:  Evaluation in Vitro and in Vivo (2003)

The objective of this study was to investigate the use of folate-targeted liposomes for the delivery of encapsulated oligonucleotides to folate receptor (FR)-positive tumor cells in vitro and in vivo. This project involved the synthesis and biological evaluation of many folate-PEG-lipid conjugates, where the chemical form of the folate moiety (pteroate) and the length of the PEG linker chain were varied widely. Folate-targeted oligonucleotide-containing liposomes were prepared using conventional methods, and the extent of cell uptake was evaluated using, among others, the FR positive KB cell line. Oligonucleotide-loaded folate-targeted liposomes were found to rapidly associate with the KB cells, and saturation was typically reached within the first hour of incubation at 37 degrees C. Nearly 100,000 liposomes per cell were bound or internalized at saturation. Importantly, cell association was blocked by a large excess folic acid, thus reflecting the FR-specific nature of the cell interaction. Full targeting potential was achieved with PEG linkers as low as 1000 in molecular weight, and pteroates bearing glycine or gamma-aminobutyryl residues juxtaposed to the pteroic acid moiety were also effective for targeting, provided that a terminal cysteine moiety was present at the distal end of the PEG chain for added hydrophilicity. When tested in vivo, folate-targeted liposomes were found to deliver approximately 1.8-fold more oligonucleotide to the livers of nude mice (relative to the nontargeted PEG-containing formulations); however, no improvement in KB tumor uptake was observed. We conclude from these results that folate liposomes can effectively deliver oligonucleotides into folate receptor-bearing cells in vitro, but additional barriers exist in vivo that prevent or decrease effective tumor uptake and retention.
Oral oligofructose‐enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin (2007)

In active ulcerative colitis, dietary supplementation with oligofructose-enriched inulin is well tolerated and is associated with early reduction in faecal calprotectin.
Location-based and preference-aware recommendation using sparse geo-social networking data (2012)

The popularity of location-based social networks provide us with a new platform to understand users' preferences based on their location histories. In this paper, we present a location-based and preference-aware recommender system that offers a particular user a set of venues (such as restaurants) within a geospatial range with the consideration of both: 1) User preferences, which are automatically learned from her location history and 2) Social opinions, which are mined from the location histories of the local experts. This recommender system can facilitate people's travel not only near their living areas but also to a city that is new to them. As a user can only visit a limited number of locations, the user-locations matrix is very sparse, leading to a big challenge to traditional collaborative filtering-based location recommender systems. The problem becomes even more challenging when people travel to a new city. To this end, we propose a novel location recommender system, which consists of two main parts: offline modeling and online recommendation. The offline modeling part models each individual's personal preferences with a weighted category hierarchy (WCH) and infers the expertise of each user in a city with respect to different category of locations according to their location histories using an iterative learning model. The online recommendation part selects candidate local experts in a geospatial range that matches the user's preferences using a preference-aware candidate selection algorithm and then infers a score of the candidate locations based on the opinions of the selected local experts. Finally, the top-k ranked locations are returned as the recommendations for the user. We evaluated our system with a large-scale real dataset collected from Foursquare. The results confirm that our method offers more effective recommendations than baselines, while having a good efficiency of providing location recommendations.
The Sympathomimetic Actions of l-Ephedrine and d-Pseudoephedrine: Direct Receptor Activation or Norepinephrine Release? (2003)

The indirectly sympathomimetic property of l-ephedrine may be one of the mechanisms to explain why ephedrine is preferred over alpha-adrenergic agonists as a vasopressor for treatment of intraspinal anesthesia-induced hypotension in obstetrics.
Hyperdocuments as automata (1993)

Article Hyperdocuments as automata: trace-based browsing property verification Share on Authors: P. David Stotts Computer Science Dept., University of North Carolina, Chapel Hill, NC Computer Science Dept., University of North Carolina, Chapel Hill, NCView Profile , Richard Furuta Computer Science Dept., University of Maryland, College Park, MD Computer Science Dept., University of Maryland, College Park, MDView Profile , J. Cyrano Ruiz Reliability Engineering Dept., University of Maryland, College Park, MD Reliability Engineering Dept., University of Maryland, College Park, MDView Profile Authors Info & Claims ECHT '92: Proceedings of the ACM conference on HypertextNovember 1992 Pages 272–281https://doi.org/10.1145/168466.171515Online:01 December 1993Publication History 15citation247DownloadsMetricsTotal Citations15Total Downloads247Last 12 Months2Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Nitrate-Dependent Regulation of Acetate Biosynthesis and Nitrate Respiration by Clostridium thermoaceticum (1999)

Nitrate has been shown to shunt the electron flow in Clostridium thermoaceticum from CO2 to nitrate, but it did not influence the levels of enzymes involved in the Wood-Ljungdahl pathway (J. M. Fröstl, C. Seifritz, and H. L. Drake, J. Bacteriol. 178:4597-4603, 1996). Here we show that under some growth conditions, nitrate does in fact repress proteins involved in the Wood-Ljungdahl pathway. The CO oxidation activity in crude extracts of nitrate (30 mM)-supplemented cultures was fivefold less than that of nitrate-free cultures, while the H2 oxidation activity was six- to sevenfold lower. The decrease in CO oxidation activity paralleled a decrease in CO dehydrogenase (CODH) protein level, as confirmed by Western blot analysis. Protein levels of CODH in nitrate-supplemented cultures were 50% lower than those in nitrate-free cultures. Western blots analyses showed that nitrate also decreased the levels of the corrinoid iron-sulfur protein (60%) and methyltransferase (70%). Surprisingly, the decrease in activity and protein levels upon nitrate supplementation was observed only when cultures were continuously sparged. Northern blot analysis indicates that the regulation of the proteins involved in the Wood-Ljungdahl pathway by nitrate is at the transcriptional level. At least a 10-fold decrease in levels of cytochrome b was observed with nitrate supplementation whether the cultures were sparged or stoppered. We also detected nitrate-inducible nitrate reductase activity (2 to 39 nmol min-1 mg-1) in crude extracts of C. thermoaceticum. Our results indicate that nitrate coordinately represses genes encoding enzymes and electron transport proteins in the Wood-Ljungdahl pathway and activates transcription of nitrate respiratory proteins. CO2 also appears to induce expression of the Wood-Ljungdahl pathway genes and repress nitrate reductase activity.
Ctree: A Compact Two-level Bidirectional Tree for Indexing XML Data (2004)

Indexing XML data to facilitate query processing has been a popular subject of study in recent years. Most of previous studies can be classified into three categories: path indexing, node indexing and sequence-based indexing. Many of them cannot answer both single-path and branching queries with various value predicates very efficiently. In this paper, we propose a novel compact tree (Ctree) structure, which provides not only concise path summaries but also detailed element relationships, and a configurable index scheme based on data statistics. We develop an efficient Ctree-based method for processing a tree structure query with various value constraints. Efficiency of our method is achieved by: (1) summarizing a large database into a condensed structure view to prune irrelevant search space; (2) evaluating a tree structure query directly without expensive join operations; (3) using Ctree properties such as trivial groups and bi-direction to reduce query processing time; (4) using a new element-referring schema to avoid expensive join operations between the matches for value constraints and those for structure constraints. Our experiments reveal that Ctree is efficient in evaluating XML queries. It is about an order of magnitude faster than most previous methods. 1.