gebhart/patrepeval huggingface dataset:
Serious game development for Ankle rehabilitation aiming at user experience (2016)

This article proposes an approach to adapt a game to ankle movement for a rehabilitation mechanism. Thus, a game was developed for ankle rehabilitation, which is inspired in the commercial version, already used with the AnkleBot (by Interactive Motion Technologies - IMT), changing both aesthetics and gameplay characteristics aiming a more intuitive and softer gameplay, improving the game experience. The movement underwent a transformation from elliptical motion, performed by the ankle, to game's rectangular workspace, better exploiting subject's movement features. For the assistance-resistance behavior the robot imposes to the user, a similar change was implemented converting a rectangular constraint to an elliptical one. These changes avoided motion discontinuity sensations to the user and provided a consistent motion for the ankle movement. Initial tests with a healthy subject showed that it is possible to adapt the game drive to the ankle movement through this mathematical transformation, better exploiting the player movement space and a smooth robot cooperation behavior, with movements more intuitive. System calibration is performed runtime, which allows not only the game to adjust itself for each patient, but also to adjust for every new achievement in patient's movement.
A New Cursive Basic Word Database for Bank-Check Processing Systems (2012)

In this paper is presented a new database for handwritten cursive basic words recognition. The database is devoted to research on bank-check processing. In fact, for security reasons, the banks rarely allow the treatment of checks handled by them. On the other hand, the reasons for the English basic words choice lie in the fact that English language is the world most commonly used for bank-check drawing. The database realised includes a considerable number of instances of basic words. Pattern images are stored using a standard image format that will be available to all researchers by Internet. The importance of this work lies in the fact that the database is queried by the network, giving the possibility to grow with the contribution of others researchers. The tagging has been generated by using the XML language that allows recovering also information on the writers. Furthermore, the information handled not only could allow the semantic recognition of the specimen but also the research development on the author identity of the manuscript. The database is an open one to be increased with the contribution of all others researchers in the world.
First demonstration of principal modes in a multimode fibre (2014)

Each principal mode of a few-mode fibre is generated and characterised for the first time, exhibiting more than an order of magnitude less modal dispersion than the idealised LP mode basis.
Transforming growth factor-beta and matrix protein expression in acute and chronic rejection of human renal allografts. (1995)

Because the increased tissue expression of TGF-beta underlies fibrosis in many diseases, it was hypothesized that sustained elevated transforming growth factor (TGF)-beta overexpression might be responsible for fibrosis in chronic rejection of the renal allograft. To test this hypothesis, biopsies were obtained from 5 patients with acute rejection, 5 patients with chronic rejection, 10 normal individuals, and 10 patients with kidney disease. The tissues were examined by immunofluorescence for the three TGF-beta isoforms (1, 2, and 3) and the two matrix proteins induced by TGF-beta that serve as markers of fibrosis: fibronectin extradomain A positive (EDA+) and plasminogen activator inhibitor-1 (PAI-1). The tubulointerstitium from all cases of acute rejection and chronic rejection showed highly significant increases in immunostaining for the three TGF-beta isoforms (P < 0.001), fibronectin EDA+ (P < 0.005), and PAI-1 (P < 0.001). In the glomeruli, only TGF-beta 1 expression achieved statistical significance (P < 0.005) in acute rejection, whereas in chronic rejection, all three TGF-beta isoforms (p < 0.001) in addition to fibronectin EDA+ (p < 0.001) and PAI-1 (p < 0.001) were elevated. There was both cellular and matrix staining of the TGF-beta isoforms. In striking contrast, control kidney tissues were negative or only weakly positive. Because TGF-beta was present both in acute and in chronic rejection but not in control tissues and because acute rejection episodes are a good predictor for chronic rejection, these results suggest that TGF-beta may play a role in the pathogenesis of fibrosis in chronic rejection.
SYNTHESIS TOWARD EPOTHILONE A : COUPLING REACTION BETWEEN THE SULFONE OF C1-C10 AND THE ALLYLIC BROMIDE OF C11-C21 (1999)

Macrolide epothilones 1 and 2, isolated by Höfle et al. from the myxobacterium Sorangium cellulosum, have been drawing considerable attention because of their novel struc-tural features and paclitaxel (Taxol®)-like antitumor activ-ity.1 The biological activity of epothilones came from their binding and stabilization of the microtubule assembly.2 But epothilones differ from paclitaxel in respect of retaining activity against multidrug-resistant cells, solubility in water, and their easy availability by fermentation. The synthetic studies have been recently exploited by many organic chemists.3 Our retrosynthetic analysis of epothilones suggests disconnection at C10-C11 bond and lactonic bond. Thus, our synthetic plans require two building blocks 3 and 4 with appropriate protecting groups (Scheme 1). The coupling reaction between the allylic bromide 3 and
Phased‐Array Intracardiac Echocardiography to Guide Radiofrequency Ablation in the Left Atrium and at the Pulmonary Vein Ostium (2001)

Phased-array ICE allows detailed assessment of LA and PV anatomy when imaged from the right atrium; accurate guidance of RFA to the PV ostium and LAA; and immediate evaluation of PV patency after RFA.
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats (2008)

Hemodynamic overload in the heart can trigger maladaptive hypertrophy of cardiomyocytes. A key signaling event in this process is nuclear acetylation by histone deacetylases and p300, an intrinsic histone acetyltransferase (HAT). It has been previously shown that curcumin, a polyphenol responsible for the yellow color of the spice turmeric, possesses HAT inhibitory activity with specificity for the p300/CREB-binding protein. We found that curcumin inhibited the hypertrophy-induced acetylation and DNA-binding abilities of GATA4, a hypertrophy-responsive transcription factor, in rat cardiomyocytes. Curcumin also disrupted the p300/GATA4 complex and repressed agonist- and p300-induced hypertrophic responses in these cells. Both the acetylated form of GATA4 and the relative levels of the p300/GATA4 complex markedly increased in rat hypertensive hearts in vivo. The effects of curcumin were examined in vivo in 2 different heart failure models: hypertensive heart disease in salt-sensitive Dahl rats and surgically induced myocardial infarction in rats. In both models, curcumin prevented deterioration of systolic function and heart failure-induced increases in both myocardial wall thickness and diameter. From these results, we conclude that inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans.
Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells (2009)

All of these findings suggest that Akt inhibition could induce the MErT through decreased NF-kappaB signaling and downregulation of Snail and Twist in OSCC cells. A strategy involving Akt inhibition might be a useful therapeutic tool in controlling cancer dissemination and metastasis in oral cancer patients.
A Comparative Study of QRD-M Detection and Sphere Decoding for MIMO-OFDM Systems (2006)

We present a comparative study of two tree search based detection algorithms, namely, the M-algorithm combined with QR decomposition (QRD-M) and the sphere decoding (SD) algorithms, for multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems. First, we show that nodes ordering before and during the tree search is important for both algorithms. With appropriate ordering, QRDM can improve detection performance significantly and SD can reduce decoding complexity substantially. Then we compare the implementation complexity of the two algorithms, in terms of the number of nodes required to search or the required number of multiplications to achieve maximum likelihood detection performance. It is interesting to show that the average complexity of SD is lower than that of QRD-M, whereas the worst case complexity of SD is much higher than that of QRD-M.
Iterative network models to predict the performance of Sierpinski fractal antennas and networks (2003)

Two simple, fast numerical models to predict the input parameters of antennas and networks whose topologies are that of the Sierpinski gasket and carpet fractal shape, are introduced. These models are based on the same recursive principle used to generate fractal structures.
Simple model of current-induced spin torque in domain walls (2007)

The effective spin pressure induced by an electric current on a domain wall in a ferromagnet is determined using a simple classical model, which allows us to extend previous theories to arbitrary domain-wall widths. In particular, the role of spatially nonuniform components of the torques are analyzed in detail. We find that in the steady state, the main effect of the current is a distortion of the wall, which should enhance depinning. We also discuss the nonadiabatic part of the torque and find that this term, responsible for the pressure on the wall, depends on the nature of spin-flip scattering events.
The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act (2018)

This review assesses the abuse potential of medically-administered psilocybin, following the structure of the 8 factors of the US Controlled Substances Act (CSA). Research suggests the potential safety and efficacy of psilocybin in treating cancer-related psychiatric distress and substance use disorders, setting the occasion for this review. A more extensive assessment of abuse potential according to an 8-factor analysis would eventually be required to guide appropriate schedule placement. Psilocybin, like other 5-HT2A agonist classic psychedelics, has limited reinforcing effects, supporting marginal, transient non-human self-administration. Nonetheless, mushrooms with variable psilocybin content are used illicitly, with a few lifetime use occasions being normative among users. Potential harms include dangerous behavior in unprepared, unsupervised users, and exacerbation of mental illness in those with or predisposed to psychotic disorders. However, scope of use and associated harms are low compared to prototypical abused drugs, and the medical model addresses these concerns with dose control, patient screening, preparation and follow-up, and session supervision in a medical facility. CONCLUSIONS: (1) psilocybin has an abuse potential appropriate for CSA scheduling if approved as medicine; (2) psilocybin can provide therapeutic benefits that may support the development of an approvable New Drug Application (NDA) but further studies are required which this review describes; (3) adverse effects of medical psilocybin are manageable when administered according to risk management approaches; and (4) although further study is required, this review suggests that placement in Schedule IV may be appropriate if a psilocybin-containing medicine is approved. This article is part of the Special Issue entitled 'Psychedelics: New Doors, Altered Perceptions'.
METHANOL-GASOLINE BLENDS PERFORMANCE IN LABORATORY TESTS AND IN VEHICLES (1975)

&lt;div class="htmlview paragraph"&gt;Blends of up to 20% methanol in gasoline were evaluated in both engine dynamometer and controlled vehicle tests, and in a 50,000 mile road test. Performance comparisons between methanol blends and base gasolines were made in vehicle driveability and vapor lock tendency, engine deposits and wear, fuel economy, exhaust emissions, compatibility with fuel system materials, and phase stability of the blends. Vapor lock tests in six 1974 cars strongly suggested that the vapor lock tendency of methanol blends is greater than would be predicted for gasolines having the same volatility characteristics. Cold start and warm-up driveability of two 1974 cars at 70°F depreciated as methanol concentration increased in base fuels of three volatility levels. These driveability data were found to correlate well, at a given methanol concentration, with fuel volatility characteristics described by means of a new fuel vaporization pressure technique. Engine deposits, rusting, wear and crankcase oil performance were not significantly affected by methanol in gasoline when evaluated in four laboratory engine tests and in the four-car, 50,000 mile road test Fuel consumption was found generally to increase with increasing methanol concentration, while exhaust emissions from both vehicles and stationary engines varied as expected from the stoichiometric air/fuel ratio of the blends. With the possible exception of copper and brass, screening tests with methanol blends indicated no serious potential compatibility problems with the fuel system metals tested or with Buna N or Neoprene rubbers. Methanol solubility in gasoline was shown to be increased by co-solvent alcohols. These also increased the stability of blends to phase separation by added water, but still phase separation occurred with as little as 0.1 or 0.2% of water.&lt;/div&gt;
Ionic Liquid Co-catalyzed Artificial Photosynthesis of CO (2013)

The conversion of CO2 to chemical feedstocks is of great importance, which yet requires the activation of thermodynamically-stable CO2 by metal catalysts or metalloenzymes. Recently, the development of metal-free organocatalysts for use in CO2 activation under ambient conditions has opened new avenues for carbon fixation chemistry. Here, we report the capture and activation of CO2 by ionic liquids and coupling to photoredox catalysis to synthesize CO. The chemical nature of anions and the organic functional groups on the imidazolium cations of ionic liquids, together with reaction medium have been demonstrated to have remarkable effects on the activation and reduction of CO2. Considering almost unlimited structural variations of ionic liquids by a flexible combination of cations and anions, this photochemical pathway provides unique opportunities for carbon fixation by rationally-designed chemical systems via linking ionic liquid based materials with chromorphoric molecules in tackling the great challenges of artificial photosynthesis.
Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds (1995)

1,1'-Dideoxygossypol (DDG), 1,1'-dideoxygossylic acid (DDGA), 8-deoxyhemigossypol (DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested for their ability to inhibit the replication of HIV in vitro. The EC50 for DDGA was < 1 microM, and its threshold cytotoxicity was approximately 20 microM. DDG was less effective than DDGA against HIV and showed considerable toxicity at 5 microM. DHGA was ineffective against HIV and had very low cytotoxicity. DHG showed some anti-HIV activity, but the threshold cytotoxicity was 5 microM. The dissociation constants for the binding of the four compounds to human serum albumin were determined by fluorescence quenching titrations, and all four were found to have much lower affinities for albumin than the parent compound gossypol.
Inherited Primary Peripheral Neuropathies (1993)

CHARCOT-MARIE-TOOTH disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are autosomal dominant, inherited primary demyelinating peripheral neuropathies that appear to result from reciprocal DNA duplication/deletion, respectively, of a 1.5-megabase (Mb) pair region on chromosome 17p. While inherited DNA rearrangements are present in most CMT1A and HNPP patients, new mutation duplication or deletion can be responsible for sporadic cases of CMT1A or HNPP. This critical 1.5-Mb region is likely to contain multiple genes, but a dosage effect of one gene that encodes a myelin protein of the peripheral nerve (<i>PMP22</i>) appears to play a critical role in the disease phenotype. Moreover,<i>PMP22</i>point mutations associated with CMT1A have been identified in patients who do not have the<i>CMT1A</i>duplication. The recent elucidation of the molecular mechanisms for CMT1A and HNPP has important clinical implications for the diagnosis, prognosis, genetic counseling, and rational approaches to therapy for
Mechanism of Complement Activation and Its Role in the Inflammatory Response After Thoracoabdominal Aortic Aneurysm Repair (2003)

The data suggest that complement activation during TAAA repair is MBL mediated, amplified through the alternative pathway, and responsible in part for the inflammatory response.
Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses. (1977)

Antisera to the type-specific internal influenza virus matrix (M) protein of a type A influenza virus were produced in goats. In the presence of complement, anti-M serum was cytotoxic for target cells which were infected with a variety of serologically distinct type A influenza viruses, but did not react with type B influenza virus-infected cells. Absorption experiments indicated that anti-M serum detected a common antigen(s) on the surface of type A-infected cells. This serological cross-reactivity parallels the cross-reactivity observed for the cytotoxic T-cell response to type A viruses.
Effect of sidearm length upon competitive alkali metal solvent extraction into chloroform by lipophilic crown phosphonic acid monoalkyl esters (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of sidearm length upon competitive alkali metal solvent extraction into chloroform by lipophilic crown phosphonic acid monoalkyl estersMichael J. Pugia, Grace. Ndip, Han Koo. Lee, Il Woo. Yang, and Richard A. BartschCite this: Anal. Chem. 1986, 58, 13, 2723–2726Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://pubs.acs.org/doi/10.1021/ac00126a031https://doi.org/10.1021/ac00126a031research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expert Systems in Clinical Microbiology (2011)

This review aims to discuss expert systems in general and how they may be used in medicine as a whole and clinical microbiology in particular (with the aid of interpretive reading). It considers rule-based systems, pattern-based systems, and data mining and introduces neural nets. A variety of noncommercial systems is described, and the central role played by the EUCAST is stressed. The need for expert rules in the environment of reset EUCAST breakpoints is also questioned. Commercial automated systems with on-board expert systems are considered, with emphasis being placed on the "big three": Vitek 2, BD Phoenix, and MicroScan. By necessity and in places, the review becomes a general review of automated system performances for the detection of specific resistance mechanisms rather than focusing solely on expert systems. Published performance evaluations of each system are drawn together and commented on critically.
Pneumocystis carinii pneumonia (1991)

Pneumocystis carinii is the major opportunistic infection in children with HIV infection and can be the initial clinical manifestation of acquired immunodeficiency syndrome. This can be particularly devastating in infants younger than 1 year of age in whom mortality excessive. In this article Walter Hughes not only reviews current insights into the diagnostic of P. carinii pneumonia but also provides the latest deliberations on prophylaxis
A Speaker-Independent Digit-Recognition System (1975)

This paper describes an implementation of a speaker-independent digit-recognition system. The digit classification scheme is based on segmenting the unknown word into three regions and then making categorical judgments as to which of six broad acoustic classes each segment falls into. The measurements made on the speech waveform include energy, zero crossings, two-pole linear predictive coding analysis, and normalized error of the linear predictive coding analysis. A formal evaluation of the systems showed an error rate of 2.7 percent for a carefully controlled recording environment and a 5.6 percent error rate for on-line recordings in a noisy computer room.
Highly accurate frequency counting system for 1.5-μm wavelength semiconductor lasers (1993)

For highly accurate optical frequency measurement in 1.5 micrometers wavelength region, an optical frequency comb (OFC) generator was realized by using a high frequency LiNbO<SUB>3</SUB> electro-optic phase modulator which was installed in a Fabry-Perot cavity. By using the OFC generator, we demonstrated the frequency difference measurement up to 0.5 [THz] with a signal-to-noise ratio higher than 61 [dB], and the heterodyne optical phase locking with a heterodyne frequency of 0.5 [THz] in which the residual phase error variance was less than 0.01 [radian<SUP>2</SUP>]. The maximum measurable frequency difference, which was defined as a sideband frequency with the signal-to-noise ratio of 0 [dB], was estimated to be 4 [THz].
Identification of a Novel Domain of HIV Tat Involved in Monocyte Chemotaxis (1998)

Human immunodeficiency virus (HIV) Tat is chemotactic for monocytes and dendritic cells, an activity that could play a key role in the expansion of HIV infection of accessory cells. To date, domains of Tat previously found to interact with cell surface molecules have shown only partial chemotactic activity toward monocytes. Using overlapping Tat peptides, we identify a novel region of Tat with a potent chemotactic activity for monocytes, reaching levels equal to Tat itself. This peptide also provokes monocyte polarization similar to Tat and is able to compete with Tat for induction of monocyte migration. Specific high affinity (kd = 3 x 10(-9) M) cell surface binding sites on monocyte cell surfaces for this region of Tat are demonstrated. These data indicate that the majority of Tat effects on monocytes are mediated by a novel region in the cysteine-rich and core domains. These domains are highly conserved among different HIV isolates, suggesting an important role in the establishment of HIV infection.