gebhart/patrepeval huggingface dataset:
Isolation and Partial Characterization of Neurofibrillary Tangles and Amyloid Plaque Core in Alzheimerʼs Disease (1986)

Fractions enriched in neurofibrillary tangles (NFT) and amyloid fibrils were isolated from the cerebral cortex of three cases of senile dementia of the Alzheimer type. Distilled water suspensions of these fractions were excluded from all pore size gels and resisted digestion with various proteolytic enzymes. Formic acid/chloroform treatment of each fraction resulted in the appearance of 4,000-6,000, 15,000-17,000 and 24,000 molecular weight proteins, with concomitant diminution in the amount of excluded material at the top of each gel. The 4,000-6,000 dalton band was best seen in fractions containing randomly arranged amyloid fibrils, and its amino acid composition resembled that of the recently reported "beta" protein. A polyclonal antiserum to purified NFT reacted with tangles in neurons and in dystrophic neurites around plaques by immunoperoxidase staining. No reaction was obtained with cerebrovascular or plaque core amyloid immunohistologically, or with the 4-6 kD protein on immunoblots. Cross-reactivity with the neurofibrillary lesions occurring in Pick's disease, progressive supranuclear palsy, postencephalitic Parkinsonism and dementia pugilistica was also seen. Specific binding of this antiserum to the double filamentous structure was confirmed by immunoelectron microscopy. Although the presence of "beta" protein in both NFT and amyloid-containing fractions suggests that it may be an important constituent of both, cross-contamination cannot be excluded.
Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery (2000)

Accelerated telomere loss has been proposed to be a factor leading to end-stage organ failure in chronic diseases of high cellular turnover such as liver cirrhosis. To test this hypothesis directly, telomerase-deficient mice, null for the essential telomerase RNA (mTR) gene, were subjected to genetic, surgical, and chemical ablation of the liver. Telomere dysfunction was associated with defects in liver regeneration and accelerated the development of liver cirrhosis in response to chronic liver injury. Adenoviral delivery of mTR into the livers of mTR(-/-) mice with short dysfunctional telomeres restored telomerase activity and telomere function, alleviated cirrhotic pathology, and improved liver function. These studies indicate that telomere dysfunction contributes to chronic diseases of continual cellular loss-replacement and encourage the evaluation of "telomerase therapy" for such diseases.
SVM-based Relevance Feedback in Image Retrieval using Invariant Feature Histograms. (2005)

Abstract — Relevance Feedback is an interesting procedure to improve the performance of Content-Based Image Retrieval systems even when using low-level features alone. In this work we compare the efficiency of one class and two class Support Vector Machines in content-based image retrieval using Invariant Feature Histograms. We describe our methodology of performing Relevance Feedback in both cases and report encouraging results on a subset of MPEG-7 content dataset. I.
Estimating the Cost of Cancer: Results on the Basis of Claims Data Analyses for Cancer Patients Diagnosed With Seven Types of Cancer During 1999 to 2000 (2004)

The economic burden of cancer is substantial. It is feasible to derive tumor-specific estimates of direct and indirect costs for large numbers of cancer patients using administrative databases. Policy makers charged with providing annual cost-of-cancer estimates should incorporate data obtained from a broad range of sources.
DNA Determinants and Substrate Specificities of Escherichia coli MutY (1995)

Potential DNA contacts involved in the specific interaction between the Escherichia coli MutY protein and a 40-mer oligonucleotide containing an A/G mismatch have been examined by alkylation interference techniques. Ethylation interference patterns suggest that more than five phosphates are involved in electrostatic interactions between MutY and DNA. Interestingly, MutY has more contacts on the G-strand than on the A-strand. Methylation at both the N-7 position of the mismatched G and the N-3 position of the mispaired A interfere with MutY binding. In addition to these mismatched bases, MutY also contacts purines on both sides of the mismatch. Binding and endonuclease activities of MutY were assayed with 20-mer oligonucleotides containing A/G, A/C, A/7,8-dihydro-8-oxo-guanine (A/GO), A/inosine (A/I), A/2-aminopurine (A/2AP), nebularine/G (N/G), inosine/G (I/G), 2AP/G, and 7-deaza-adenosine/G (Z/G) mispairs. The C-8 keto group of GO in A/GO contributes to a much tighter binding but weaker endonuclease activity than is seen with A/G. Because A/I is not specifically well recognized by MutY, the 2-amino group of G in A/G is essential for recognition. The C-6 keto group present in A/G but absent in A/2AP is also important for recognition. The 6-amino group of adenine appears not to be required for either binding or endonuclease activity because N/G is as good a substrate as A/G. The 2AP/G mispair is bound and cleaved weaker than is the A/G mispair. Binding and endonuclease activities are abolished when the N-7 group of A is replaced by C-7 as in the Z/G mispair. When a C-6 keto group is present as in the I/G pair, its binding by MutY is as good as for A/G, but no endonuclease activity is observed. Taken together, our data suggest that DNA sequences proximal to and specific functional groups of mismatched bases are necessary for recognition and catalysis by MutY protein.
14‐3‐3 protein η chain gene (YWHAH) polymorphism and its genetic association with schizophrenia (1999)

Recent genetic analyses have suggested a linkage between schizophrenia and the chromosomal region 22q12–q13. 14-3-3 protein, abundant in the brain, mediates interactions between diverse molecules of biological activities; its gene was recently mapped to chromosome 22q12.1–q13.1. We therefore investigated allele frequencies of a variable number of tandem repeat (VNTR) in the 5′-noncoding region of the 14-3-3 η chain gene in controls and schizophrenics. The frequencies of the two-repeat allele were significantly higher (P < 0.05) in the schizophrenics, and particularly in those with onset before age 22 (early-onset schizophrenics, P < 0.02), than in the controls. The odds ratio was significantly increased in the early-onset schizophrenics homozygous for the two-repeat allele (OR = 3.3, 95% CI = 1.1—9.7). The 14-3-3 η chain gene is a potential susceptibility gene for schizophrenia, and particularly for early-onset schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:164–167, 1999. © 1999 Wiley-Liss, Inc.
Aberrant growth of granulocyte-macrophage progenitors in juvenile chronic myelogenous leukemia in serum-free culture. (1996)

We investigated the properties of granulocyte-macrophage (GM) progenitors obtained from patients with juvenile chronic myelogenous leukemia (JCML). CD34+ bone marrow cells from a patient with JCML, unlike normal bone marrow cells, generated a large number of cells in serum-containing liquid culture without additional hematopoietic factors. In serum-deprived culture, only granulocyte colony-stimulating factor (G-CSF) had a modest stimulatory effect on GM colony growth in normal controls. In contrast, stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-3 (IL-3), as well as G-CSF, when tested individually, generated significant numbers of GM colonies in some JCML patients. All two-factor combinations generated significantly more GM colonies in JCML compared with normal controls. In particular, GM-CSF plus SCF exerted an interaction equivalent to the all-factor combination in most patients. Significant differences in the size and constituent cells of GM colonies stimulated by GM-CSF plus SCF were also observed. These results suggest that one possible mechanism for the excessive cell production in JCML is the strong proliferation of GM progenitors induced by hematopoietic factors, especially SCF. According to immunofluorescent analysis, however, it is unlikely that this multiplication is due to an increase in the cell surface expression of c-kit receptors on JCML progenitors.
Synthese potentieller Metaboliten des 2‐Amino‐N‐(β‐hydroxy‐2,5‐dimethoxyphenäthyl)‐acetamids (Midodrin) (1975)

Abstract 2,5‐Dimethoxymandelsäure, 2,5‐Dimethoxyphenylglykol sowie deren Desmethylderivate werden–ausgehend von entsprechenden Benzaldehyden–synthetisiert, wobei die freien phenolischen Hydroxylgruppen während der Synthese durch Benzylierung geschützt werden müssen.
D6.2 - An Ultra-Low Power Wake-Up Receiver for Real-time constrained Wireless Sensor Networks (2015)

Most Wireless Sensor Networks (WSNs) are considered out of reach when deployed in harsh environment.Energy consumption is a critical feature as these networks incorporate battery-powered devices known as wireless sensor nodes (WSn).Typically, the majority of applications don't need from nodes to remain active all the time.However, what is called idle listening waste most of the energy since the radio transceiver is constantly active.In case of real-time application, the energy-hungry chip remains in idle state, consuming power when communication traffic is considerably low.On the other hand, putting it into sleep state disconnects the node from the network.To cope with such challenge, an ultra-low power radio receiver referred as Wake-Up Receiver (WuRx) handles the idle listening while keeping the main radio completely off.The WuRx consumes much less power than the main transceiver.Embedding such device enables more event-triggered applications where real-time behavior is critical and longer lifetime is mandatory.The WuRx suffers from mediocre sensitivity and signal selectivity as it includes the minimum number of active components in order to remain within the power budget.In this paper, we introduce an ultra-low power WuRx that drains less than 3 µA with a sensitivity -60 dBm.The device can decode a 16-bit wake-up packet (WuPt) with minimally 1% of PER in nearly 10 ms.
High Levels of Urinary Vascular Endothelial Growth Factor in Women with Severe Preeclampsia (2004)

Elevated plasma VEGF concentrations in preeclampsia are associated with local placental ischemia and endothelial dysfunction. We investigated the urinary VEGF excretion in women with severe preeclampsia (n=37) and its relation with proteinuria compared to that in healthy pregnant (n=32) and non-pregnant women (n=30). In women with severe preeclampsia VEGF levels were 54.0 (19.9–192.4) ng/mmol creatinine, significantly (p&lt;0.0001) higher than levels in pregnant controls (28.2 (6.7–63.0) ng/mmol creatinine) and non-pregnant controls (29.5 (10.1–59.1) ng/mmol creatinine). Proteinuria was not significantly correlated with urinary VEGF levels. In conclusion, high urinary VEGF concentrations in severe preeclampsia might reflect increased renal production of VEGF rather than elevated VEGF levels in the systemic circulation.
Molecular Organization of Sarcoglycan Complex in Mouse Myotubes in Culture (1998)

The sarcoglycans are a complex of four transmembrane proteins (alpha, beta, gamma, and delta) which are primarily expressed in skeletal muscle and are closely associated with dystrophin and the dystroglycans in the muscle membrane. Mutations in the sarcoglycans are responsible for four autosomal recessive forms of muscular dystrophy. The function and the organization of the sarcoglycan complex are unknown. We have used coimmunoprecipitation and in vivo cross-linking techniques to analyze the sarcoglycan complex in cultured mouse myotubes. We demonstrate that the interaction between beta- and delta-sarcoglycan is resistant to high concentrations of SDS and alpha-sarcoglycan is less tightly associated with other members of the complex. Cross-linking experiments show that beta-, gamma-, and delta-sarcoglycan are in close proximity to one another and that delta-sarcoglycan can be cross-linked to the dystroglycan complex. In addition, three of the sarcoglycans (beta, gamma, and delta) are shown to form intramolecular disulfide bonds. These studies further our knowledge of the structure of the sarcoglycan complex. Our proposed model of their interactions helps to explain some of the emerging data on the consequences of mutations in the individual sarcoglycans, their effect on the complex, and potentially the clinical course of muscular dystrophies.
Temperature-controlled surface plasmon resonance in VO_2 nanorods (2002)

The optical properties of VO(2) nanoparticles formed in an amorphous SiO(2) host by stoichiometric ion implantation of vanadium and oxygen and thermal annealing have been determined and correlated with the particle size and morphology. The results show that that the temperature-controlled semiconductor-to-metal phase transition of the VO(2) nanophase precipitates turns on the classical surface plasmon resonance, with specific features that depend on the size and aspect ratio of the VO(2) particles. This effect improves the optical contrast between the metallic and semiconducting states in the near-IR region of the spectrum as a result of dielectric confinement that is due to the SiO(2) host. A fiber-optic application is demonstrated, as is the ability to control the characteristics of the phase transition by using ion implantation to dope the VO(2) nanoparticles with tungsten or titanium ions.
A correction method of deep laterolog responses under under-balanced logging conditions (2008)

Under-balanced drilling and under-balanced logging are very important techniques for directly identifying and protecting hydrocarbon reservoirs and enhancing productivity. The wellhead assembly under under-balanced logging is greatly different from that under conventional logging. Therefore, the length of cable electrode for dual laterolog should be reduced to adapt to the wellhead assembly, which causes the deep laterolog responses to drop and cannot truly reflect the reservoir property. The rule of electrode coefficient varying with the cable electrode length under under-balanced conditions has been computed using finite element method, that is, the longer the cable electrode, the smaller the electrode coefficient. The deep laterolog resistivity correction method under under-balanced condition is introduced. Field data examples are used to test the new method and shows that this method is reliable. This method can be used to any length of cable electrode and can be applied to field pretreatment directly. The corrected deep laterolog resistivity can be used in logging interpretation and quantitative hydrocarbon evaluation.
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis (2012)

Regulator of telomere length 1 (RTEL1) is a DNA helicase protein that has been demonstrated to be required for the maintenance of telomere length and genomic stability. It has also been found to be essential for DNA homologous recombination during DNA repairing. Human RTEL1 genomic locus (20q13.3) is frequently amplified in multiple types of human cancers, including hepatocellular carcinoma and gastrointestinal tract tumors, indicating that upregulated RTEL1 activity could be important for tumorigenesis. In this study, we have developed a conditional transgenic mouse model that overexpress mouse Rtel1 in a Cre-excision manner. By crossing with a ubiquitous Cre mouse line, we further demonstrated that these established Rtel1 conditional transgenic mice allow to efficiently and highly express a functional Rtel1 that is able to rescue the embryonic defects of Rtel1 null mouse allele. Furthermore, we demonstrated that more than 70% transgenic mice that widely overexpress Rtel1 developed liver tumors that recapitulate many malignant features of human hepatocellular carcinoma (HCC). Our work not only generated a valuable mouse model for determining the role of RTEL1 in the development of cancers, but also provided the first genetic evidence to support that amplification of RTEL1, as observed in several types of human cancers, is tumorigenic.
Anonymous attribute authentication scheme using self-blindable certificates (2008)

In this paper, we propose a perfectly anonymous attribute authentication scheme that is both unidentifiable and untraceable. The proposed scheme employs a self-blindable certificate that a user is able to change randomly; thus the certificate is modified for each authentication, and the authentication scheme is unidentifiable and untraceable. Furthermore, our scheme can revoke issued self-blindable certificates without leaks of confidential private information and check the revocation status without online access.
2维美景、3维人物一起来《征服》 (2003)

《征服》游戏属于ARPG Online类型,以中国古代的武侠世界为背景,在这世界里,各种各样的奇人怪事发生在你的身边,吸引着你去探险,游历。深厚的文化底蕴拓展出一个极尽动作游戏精华的游戏空间。游戏场景跨度广阔,以2维技术渲染出的场景气势恢宏,极具特色。黄沙大漠的荒凉,芦花荡中的水天之地,枫溪林的红枫靓景……处处给人以新颖感觉。以精湛的3D技术构造出的人物、怪兽,配合上先进的动作捕捉系统,展现出角色惟妙惟肖的模拟体系。五大职业体系设定,骁勇擅战的战士、强悍勇猛的勇士、法术精湛的道士还有行侠仗义的侠客与百步穿杨的弓箭手,各职业下属繁杂的分支细职,创建出令人惊讶的武侠社会网,千种组合,万般变化,远程系、近战系、辅助系、魔法系……上百种的技能配合职业,为游戏带来更多的乐趣。十八般兵器皆登场,名兵利甲、战盔道袍,首次引入的格斗游戏XP技能的独特创意设计为网游世界最完善的PK系统增添了极致的游戏体验。
Effects of HIV disease on lipid, glucose and insulin levels: results from a large antiretroviral‐naïve cohort (2005)

Both HIV disease and demographic characteristics were found to influence lipid values and glucose homeostasis in the absence of antiretroviral treatment. More advanced HIV disease was associated with less favourable lipid and glucose homeostatic profiles. The independent association between HIV RNA levels and various lipid parameters suggests that viral replication had a direct effect on lipid levels. Interpretation of the effects of various HIV treatment regimen and drugs on metabolic parameters must take into account the stage of HIV disease and the demographic characteristics of the population studied.
Deinking with enzymes : a review (1998)

Biotechnological processes are receiving greater attention as industry seeks to reduced its impact on the environment. In the pulping arena, enzyme-based deinking shows promise as a means of reducing chemical use and wastewater treatment. Brightness response to enzyme treatment varies considerably, but it often rivals or surpasses brightnesses obtained with conventional deinking processes. Residual dirt count for enzymatically deinked pulps is also generally lower. Additional benefits include higher freeness and greater paper strength. Results for pulp yield are inconclusive. While the potential of enzyme-based deinking appears to be quite good, further research in a few areas is needed to fully exploit the same. Application : an overview of recent developments in the use of enzymes for deinking.
Generalized fractal transforms: complexity issues (2002)

The Bath Fractal Transform (BFT) defines a strategy for obtaining least squares fractal approximations and can be implemented using functions of varying complexity. The approximation method used in ITT-coding is itself the zero-order instance of the BFT. Some of the complexity options available are explored by combining various orders of BFT approximation with various degrees and types of searching. This may be regarded either as the inclusion of searching with the BFT or as a generalization of the matching criterion of ITT-coding. This is considered from the point of view of the cost-fidelity trade-offs incurred, and the implications for practical application to multimedia information retrieval systems and real-time video are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Comp2Watch (2011)

The mobile devices have been widely spread and become frequently used equipment in daily life. Besides, watching videos on these devices has become a more and more popular activity. However, there are several challenges (e.g., small mobile screen size, low bandwidth, fragmented watching time) hindering mobile video watching: they either interrupt the watching process or limit users to browse many contents at the same time. Traditional video summarization techniques are suffering the small screen issue. Therefore, we propose a system, Comp2Watch which is pronounced like "come to watch". It implies the meaning of "composing the frames into a collage" and "compressing the watching time". It puts ROI factors into consideration in order to help users take a quick glance at videos. Also, we modify the cost function to incorporate the templates with variable aspect ratios. We also address the monotone layout problem caused by the limited space. The experimental results show that users can obtain clearer subject without losing many contexts.
Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei) (2008)

The potential induction of a programmed cell death (PCD) in Trypanosoma b. brucei by 55 alkaloids of the quinoline, quinolizidine, isoquinoline, indole, terpene, tropane, steroid, and piperidine type was studied by measuring DNA fragmentation and changes in mitochondrial membrane potential. For comparison, the induction of apoptosis by the same alkaloids in human leukemia cells (Jurkat APO-S) was tested. Several alkaloids of the isoquinoline, quinoline, indole and steroidal type (berberine, chelerythrine, emetine, sanguinarine, quinine, ajmalicine, ergotamine, harmine, vinblastine, vincristine, colchicine, chaconine, demissidine and veratridine) induced programmed cell death, whereas quinolizidine, tropane, terpene and piperidine alkaloids were mostly inactive. Effective PCD induction (EC(50) below 10 microM) was caused in T. brucei by chelerythrine, emetine, sanguinarine, and chaconine. The active alkaloids can be characterized by their general property to inhibit protein biosynthesis, to intercalate DNA, to disturb membrane fluidity or to inhibit microtubule formation.
A dose range finding study of novel oral insulin (IN‐105) under fed conditions in type 2 diabetes mellitus subjects (2010)

IN-105 absorption is proportional to the dose administered. The 2-h postprandial glucose excursion was reduced in a dose proportional manner. Circulating C-peptide levels were found to be suppressed in proportion to the IN-105 exposure. IN-105 reduces glucose excursion despite lower endogenous insulin secretion. IN-105 seems to have a wide therapeutic window as no clinical hypoglycaemia was observed at any of the doses studied.