gebhart/patrepeval huggingface dataset:
From Wine to Pepper: Rotundone, an Obscure Sesquiterpene, Is a Potent Spicy Aroma Compound (2008)

An obscure sesquiterpene, rotundone, has been identified as a hitherto unrecognized important aroma impact compound with a strong spicy, peppercorn aroma. Excellent correlations were observed between the concentration of rotundone and the mean 'black pepper' aroma intensity rated by sensory panels for both grape and wine samples, indicating that rotundone is a major contributor to peppery characters in Shiraz grapes and wine (and to a lesser extent in wine of other varieties). Approximately 80% of a sensory panel were very sensitive to the aroma of rotundone (aroma detection threshold levels of 16 ng/L in red wine and 8 ng/L in water). Above these concentrations, these panelists described the spiked samples as more 'peppery' and 'spicy'. However, approximately 20% of panelists could not detect this compound at the highest concentration tested (4000 ng/L), even in water. Thus, the sensory experiences of two consumers enjoying the same glass of Shiraz wine might be very different. Rotundone was found in much higher amounts in other common herbs and spices, especially black and white peppercorns, where it was present at approximately 10000 times the level found in very 'peppery' wine. Rotundone is the first compound found in black or white peppercorns that has a distinctive peppery aroma. Rotundone has an odor activity value in pepper on the order of 50000-250000 and is, on this criterion, by far the most powerful aroma compound yet found in that most important spice.
Detecting Malicious Software by Monitoring Anomalous Windows Registry Accesses (2002)

We present a host-based intrusion detection system (IDS) for Microsoft Windows. The core of the system is an algorithm that detects attacks on a host machine by looking for anomalous accesses to the Windows Registry. The key idea is to first train a model of normal registry behavior on a windows host, and use this model to detect abnormal registry accesses at run-time. The normal model is trained using clean (attack-free) data. At run-time the model is used to check each access to the registry in real time to determine whether or not the behavior is abnormal and (possibly) corresponds to an attack. The system is effective in detecting the actions of malicious software while maintaining a low rate of false alarms.
A candidate precursor to serous carcinoma that originates in the distal fallopian tube (2006)

The tubal fimbria is a common site of origin for early (tubal intraepithelial carcinoma or TIC) serous carcinomas in women with familial BRCA1 or 2 mutations (BRCA+). Somatic p53 tumour suppressor gene mutations in these tumours suggest a pathogenesis involving DNA damage, p53 mutation, and progressive loss of cell cycle control. We recently identified foci of strong p53 immunostaining-termed 'p53 signatures'-in benign tubal mucosa from BRCA+ women. To examine the relationship between p53 signatures and TIC, we compared location (fimbria vs ampulla), cell type (ciliated vs secretory), evidence of DNA damage, and p53 mutation status between the two entities. p53 signatures were equally common in non-neoplastic tubes from BRCA+ women and controls, but more frequently present (53%) and multifocal (67%) in fallopian tubes also containing TIC. Like prior studies of TIC, p53 signatures predominated in the fimbriae (80-100%) and targeted secretory cells (HMFG2 + /p73-), with evidence of DNA damage by co-localization of gamma-H2AX. Laser-capture microdissected and polymerase chain reaction-amplified DNA revealed reproducible p53 mutations in eight of 14 fully-analysed p53 signatures and all of the 12 TICs; TICs and their associated ovarian carcinomas shared identical mutations. In one case, a contiguous p53 signature and TIC shared the same mutation. Morphological intermediates between the two, with p53 mutations and moderate proliferative activity, were also seen. This is the first report of an early and distinct alteration in non-neoplastic upper genital tract mucosa that fulfils many requirements for a precursor to pelvic serous cancer. The p53 signature and its malignant counterpart (TIC) underline the significance of the fimbria, both as a candidate site for serous carcinogenesis and as a target for future research on the early detection and prevention of this disease.
Capacitive coupling and quantized feedback applied to conventional CMOS technology (1997)

An on-chip capacitor is formed under the bond pad to block the DC level of input signals. Capacitively coupled signals suffer the "zero wander" effect which causes the local DC level on the second plate of the capacitor to be dependent on the bit activity rate. A quantized feedback technique using a self-triggered decision circuit is used to reestablish local DC voltage levels in the receiver and eliminates the "zero wander" effect. The input signals can be detected over a large common mode range independent of the bit activity rate and over a large frequency range. Silicon area and power dissipation are reduced since encoding and decoding of the bit stream is not required. The circuit has been implemented in silicon using a conventional digital 0.5 /spl mu/m CMOS technology. This receiver can detect a 2/sup 31/-1 pseudorandom pattern at 800 Mb/s with no errors and can operate down to a data rate of 2 kHz.
On future’s doorstep: RNA interference and the pharmacopeia of tomorrow (2007)

Small molecules and antibodies have revolutionized the treatment of malignant diseases and appear promising for the treatment of many others. Nonetheless, there are many candidate therapeutic targets that are not amenable to attack by the current generation of targeted therapies, and in a small but growing number of patients, resistance to initially successful treatments evolves. This Review Series on the medicinal promise of posttranscriptional gene silencing with small interfering RNA and other molecules capable of inducing RNA interference (RNAi) is motivated by the hypothesis that effectors of RNAi can be developed into effective drugs for treating malignancies as well as many other types of disease. As this Review Series points out, there is still much to do, but many in the field now hope that the time has finally arrived when "antisense" therapies will finally come of age and fulfill their promise as the magic bullets of the 21st century.
Characterization of an ERK-binding Domain in Microphthalmia-associated Transcription Factor and Differential Inhibition of ERK2-mediated Substrate Phosphorylation (2005)

Efficient and specific signaling by mitogen-activated protein kinases (MAPKs) is enhanced by docking sites found on many MAPK substrates and regulators. Here we show that the MAPKs ERK1 and ERK2 form a stable complex (Kd approximately 6 microm) with their substrate the microphthalmia-associated transcription factor (MITF). Complex formation requires a domain of MITF of approximately 100 residues that is nearby, but C-terminal to, the MAPK phosphorylation site at Ser73. MITF derivatives lacking this ERK-binding domain do not bind ERK2 and are phosphorylated less efficiently by ERK2. The ERK-binding domain of MITF bears no obvious resemblance to previously characterized MAPK docking motifs; in particular, it does not contain a consensus D-site. Consistent with this, ERK2-MITF binding does not require the integrity of the CD/sevenmaker region of ERK2. Furthermore, D-site peptides, which are able to potently inhibit ERK2-mediated phosphorylation of the Elk-1 transcription factor (IC50= 3 microm), are relatively poor inhibitors of ERK2-mediated phosphorylation of MITF, exhibiting >15-fold selectivity for inhibition of Elk-1 versus MITF. These observations demonstrate substrate-selective kinase inhibition: the possibility that small molecules that target docking interactions may be used to selectively inhibit the phosphorylation of a subset of the substrates of a kinase.
Determinants of Ligand Specificity of Estrogen Receptor-α: Estrogen versus Androgen Discrimination (1998)

We have been interested in understanding how the estrogen receptor (ER) binds estrogens and discriminates between different classes of steroids with closely related structures. Using insights from our prior studies on ER and from sequence comparisons of steroid receptors, we identified three residues in the hormone-binding domain of the human ER, Leu345, Thr347, and Glu353, that we considered were likely to be involved in steroid A-ring recognition and therefore estrogen versus androgen discrimination. We then tested the effect on ER activity of mutating these ER residues to the corresponding androgen receptor residues. Specifically, we examined the ability of the mutant receptors to bind and be activated by 17beta-estradiol and three different androgens. No change in receptor activity was observed with the T347N mutation, while the L345S mutation greatly reduced ER activity in response to all ligands. Interestingly, the E353Q substitution behaved as expected, causing a 9-fold reduction in the transactivation potency of estradiol and a concomitant 10-140-fold increase in the transactivation potency of different androgens. These reciprocal changes in the transcriptional effectiveness of estrogens and androgens correlated with a decreased affinity of the E353Q ER for estradiol binding and an increased affinity for androgen binding. Therefore, amino acid Glu353 appears to be playing a significant role in binding the A-ring phenolic group of estradiol and in receptor discrimination between estrogens and the most closely structurally related steroids, androgens. Based on this data and our earlier observations, we propose a model for the orientation of ligand within the binding pocket of ER in which the A-ring 3-phenol of estradiol is hydrogen bonded to Glu353 in helix-3 and the 17beta-hydroxyl of estradiol is hydrogen bonded to His524 in helix-11. Our findings with estrogen and androgen suggest that this orientation of the steroid in the ligand-binding pocket, with the steroid A-ring in contact with helix-3 and the D-ring in contact with helix-11 residues, is likely to be general for all the steroid hormone receptors.
Saving and using encountered information (2005)

As part of a focus on electronic publications, we undertook an exploratory study of how people saved and used the information they encountered while reading. In particular, we wanted to understand the role of clipping and whether it would be a necessary form of interaction with electronic publications. We interviewed 20 diverse individuals at home and at work, bringing together narrative accounts and physical and digital examples to investigate how people currently collect and use clippings from their everyday reading. All study participants had examples of materials they had deliberately saved from periodicals, ranging from ads torn from newspapers and URLs received in email messages to large stacks of magazines. Participants rarely read periodicals specifically to clip but rather recognized items of interest when they were encountered. The work highlights the importance of encountering information as an activity distinct from task-focused browsing and searching and reveals design implications for online reading and clipping technologies.
Compiling path queries (2016)

Measuring the flow of traffic along network paths is crucial for many management tasks, including traf-fic engineering, diagnosing congestion, and mitigating DDoS attacks. We introduce a declarative query lan-guage for efficient path-based traffic monitoring. Path queries are specified as regular expressions over predi-cates on packet locations and header values, with SQL-like “groupby ” constructs for aggregating results any-where along a path. A run-time system compiles queries into a deterministic finite automaton. The automaton’s transition function is then partitioned, compiled into match-action rules, and distributed over the switches. Switches stamp packets with automaton states to track the progress towards fulfilling a query. Only when pack-ets satisfy a query are they packet counted, sampled, or sent to collectors for further analysis. By processing queries in the data plane, users “pay as they go”, as data-collection overhead is limited to exactly those packets that satisfy the query. We implemented our system on top of the Pyretic SDN controller and evaluated its perfor-mance on a campus topology. Our experiments indicate that the system can enable “interactive debugging”— compiling multiple queries in a few seconds—while fit-ting rules comfortably in modern switch TCAMs and the automaton state into two bytes (e.g., a VLAN header). 1
Self-Organized Growth of Three- Dimensional Quantum-Dot Crystals with fcc-Like Stacking and a Tunable Lattice Constant (1998)

The self-organization of pyramidal PbSe islands that spontaneously form during strained-layer epitaxial growth of PbSe/Pb1-xEuxTe (x = 0.05 to 0.1) superlattices results in the formation of three-dimensional quantum-dot crystals. In these crystals, the dots are arranged in a trigonal lattice with a face-centered cubic (fcc)-like A-B-C-A-B-C vertical stacking sequence. The lattice constant of the dot crystal can be tuned continuously by changing the superlattice period. As shown by theoretical calculations, the elastic anisotropy in these artificial dot crystals acts in a manner similar to that of the directed chemical bonds of crystalline solids. The narrow size distribution and excellent control of the dot arrangement may be advantageous for optoelectronic device applications.
Electronic Properties and Metrology Applications of the DiamondNV−Center under Pressure (2014)

The negatively charged nitrogen-vacancy (NV-) center in diamond has realized new frontiers in quantum technology. Here, the optical and spin resonances of the NV- center are observed under hydrostatic pressures up to 60 GPa. Our results motivate powerful new techniques to measure pressure and image high-pressure magnetic and electric phenomena. Additionally, molecular orbital analysis and semiclassical calculations provide insight into the effects of compression on the electronic orbitals of the NV- center.
Interface Design and Implementation of Digital Image Processing Platform (2010)

The appearance of visual programming language has brought great changes to the design of man-machine interface.In the paper, through the research on current visual programming, a graph control is proposed and used as an interface design of an image processing platform.Algorithm information, which is implemented by DLL of VC, is encapsulated in these graphical controls through the use of packaging technology, and users can develop their own software by using the graphical controls, in order to avoid the compililation of code and improve the speed of image processing.The development methods of graphical controls can enhance the flexibility of configuration and improve development efficiency, and to achieve software reuse.
Dominant-Negative Action of Disease-Causing Gonadotropin-Releasing Hormone Receptor (GnRHR) Mutants: A Trait That Potentially Coevolved with Decreased Plasma Membrane Expression of GnRHR in Humans (2003)

Loss of function by 11 of 13 naturally occurring mutations in the human GnRH receptor (hGnRHR) was thought to result from impaired ligand binding or effector coupling, but actually results from receptor misrouting. Homo- or heterodimerization of mutant receptors with wild-type (WT) receptors occurs for other G protein-coupled receptors and may result in dominant-negative or -positive effects on the WT receptor. We tested the hypothesis that WT hGnRHR function was affected by misfolded hGnRHR mutants. hGnRHR mutants were found to inhibit the function of WT GnRHR (measured by activation of effector and ligand binding). Inhibition varied depending on the particular hGnRHR mutant coexpressed and the ratio of hGnRHR mutant to WT hGnRHR cDNA cotransfected. The hGnRHR mutants did not interfere with the function of genetically modified hGnRHRs bearing either a deletion of primate-specific Lys(191) or the carboxyl-terminal tail of the catfish GnRHR; these show intrinsically enhanced expression. Moreover, a peptidomimetic antagonist of GnRH enhanced the expression of WT hGnRHR, but not of genetically modified hGnRHR species. The dominant-negative effect of the naturally occurring receptor mutants occurred only for the WT hGnRHR, which has intrinsic low maturation efficiency. The data suggest that this dominant negative effect accompanies the diminished plasma membrane expression as a recent evolutionary event.
Cost analysis of pancreatic carcinoma treatment (2000)

The costs of treating patients with pancreatic carcinoma are considerable, even though survival duration typically is short. Disease stage was the most dominating factor determining costs and survival. After controlling for disease stage, chemotherapy, surgery, and dual insurance coverage were also significantly associated with higher cost of care. However, in survival analyses, only chemotherapy and radiation therapy were associated with a significant increase in patient survival.
Targeted non-viral gene delivery for cancer gene therapy (1998)

The ability to mediate targeted and specific delivery of therapeutics to cancer cells remains one of the most important hurdles in effectively treating cancer. This aspect also remains as one of the greatest limitations of gene therapy as well. Targeted vectors based on the use of DNA-binding agents attached to cell specific ligands or "molecular conjugates" were created with the goal of over-coming this hurdle. Since being conceived, many different ligands have been utilized as molecular conjugates, targeting the resulting Protein/DNA polyplex to cells efficiently in vitro while mediating limited delivery in vivo. This limited delivery is due to many reasons such as the need to identify non-viral agents that can aide in escaping endosome entrapment as well as decreasing the complexity that has evolved in the creation of these "synthetic viruses". This review will discuss the current status and the future of molecular conjugates as targeting vectors as well as the positive and negative attributes of this vector in relation to other viral and non-viral vectors that are currently used in many gene therapy strategies.
Study on Reliability Assessment Procedures for Torsion Spring of Vehicle Door Latch (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Retinopathy of prematurity: A study of prevalence and risk factors (2012)

The prevalence of ROP in this study was 19.2%; low gestational age, sepsis, oxygen therapy, and frequent blood transfusions were significant risk factors for ROP. Laser was effective in treatment and decreasing the progression of ROP. As this is a unit-based study, a comprehensive countrywide survey on ROP in Egypt is recommended to determine any regional differences in disease prevalence.
( S )-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity (1978)

(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
Yeast tRNA-splicing endonuclease is a heterotrimeric enzyme. (1990)

tRNA-splicing endonuclease from the yeast Saccharomyces cerevisiae was purified to homogeneity greater than 5000-fold over a crude Triton X-100 extract of yeast total membranes, with 5% overall yield. This nuclear enzyme has the unusual heterotrimeric subunit structure alpha beta gamma (alpha = 31 kDa, beta = 42 kDa, and gamma = 51 kDa), as determined by sodium dodecyl sulfate gel electrophoresis, and has a molecular mass close to the sum of the three subunits, as determined by gel filtration of the native enzyme. From the purification, we estimate that there are approximately 100 molecules of endonuclease/cell.
Immunotherapy with cytokine gene-transduced tumor cells (1992)

Recently, new tumor vaccine approaches were developed in animal systems that modify tumor cells genetically to secrete certain cytokines. Engineering tumor cells to secrete cytokines in a paracrine fashion can induce powerful local cytokine effects without producing significant systemic toxicity. In addition to local inflammation, this approach can alter the presentation of tumor antigens or activation of tumor antigen-specific T lymphocytes, resulting in systemic antitumor immunity. The development of high efficiency gene transfer technologies such as defective retroviral vectors allows for the translation of these preclinical studies to clinical trials. However, before large investments are made in this area of gene therapy, it will be important to demonstrate that the actual gene transfer component of the strategy significantly enhances antitumor immune responses relative to alternative nongenetic approaches.
Formulation concerns of protein drugs (1992)

(1992). Formulation concerns of protein drugs. Drug Development and Industrial Pharmacy: Vol. 18, No. 11-12, pp. 1311-1354.
Performance evaluation of web servers using central load balancing policy over virtual machines on cloud (2010)

Cloud Computing adds more power to the existing Internet technologies. Virtualization harnesses the power of the existing infrastructure and resources. With virtualization we can simultaneously run multiple instances of different commodity operating systems. Since we have limited processors and jobs work in concurrent fashion, overload situations can occur. Things become even more challenging in distributed environment. We propose Central Load Balancing Policy for Virtual Machines (CLBVM) to balance the load evenly in a distributed virtual machine/cloud computing environment. This work tries to compare the performance of web servers based on our CLBVM policy and independent virtual machine(VM) running on a single physical server using Xen Virtualizaion. The paper discusses the efficacy and feasibility of using this kind of policy for overall performance improvement.
Macrophages in human colorectal cancer are pro‐inflammatory and prime T cells towards an anti‐tumour type‐1 inflammatory response (2011)

High macrophage infiltration into tumours often correlates with poor prognoses; in colorectal, stomach and skin cancers, however, the opposite is observed but the mechanisms behind this phenomenon remain unclear. Here, we sought to understand how tumour-associated macrophages (TAMs) in colorectal cancer execute tumour-suppressive roles. We found that TAMs in a colorectal cancer model were pro-inflammatory and inhibited the proliferation of tumour cells. TAMs also produced chemokines that attract T cells, stimulated proliferation of allogeneic T cells and activated type-1 T cells associated with anti-tumour immune responses. Using colorectal tumour tissues, we verified that TAMs in vivo were indeed pro-inflammatory. Furthermore, the number of tumour-infiltrating T cells correlated with the number of TAMs, suggesting that TAMs could attract T cells; and indeed, type-1 T cells were present in the tumour tissues. Patient clinical data suggested that TAMs exerted tumour-suppressive effects with the help of T cells. Hence, the tumour-suppressive mechanisms of TAMs in colorectal cancer involve the inhibition of tumour cell proliferation alongside the production of pro-inflammatory cytokines, chemokines and promoting type-1 T-cell responses. These new findings would contribute to the development of future cancer immunotherapies based on enhancing the tumour-suppressive properties of TAMs to boost anti-tumour immune responses.