gebhart/patrepeval huggingface dataset:
Mining specifications of malicious behavior (2008)

Malware detectors require a specification of maliciousbehavior. Typically, these specifications are manually constructedby investigating known malware. We present an automatic technique to overcome this laborious manual process. Our technique derives such a specification by comparing the execution behavior of a known malware against the execution behaviors of a set of benign programs. In other words, we mine the malicious behavior present in a known malware that is not present in a set of benign programs. The output of our algorithm can be used by malware detectors to detect malware variants. Since our algorithm provides a succinct description of malicious behavior present in a malware, it can also be used by security analysts for understanding the malware. We have implemented a prototype based on our algorithm and tested it on several malware programs. Experimental results obtained from our prototype indicate that our algorithm is effective in extracting malicious behaviors that can be used to detect malware variants
Indoor pedestrian navigation using miniaturized low-cost MEMS inertial measurement units (2014)

The paper presents an indoor pedestrian navigation system using miniaturized low-cost MEMS inertial measurement units (IMU). The low-cost MEMS IMU comprises of a tri-axial accelerometer, a tri-axial gyroscope, a tri-axial magnetometer, which are widely available in most smartphones, tablets, and other handheld devices. Through comparison tests of the IMU fixed on chest and foot, we found that the foot-mounted location is the proximate position, reflecting human's waking kinetic. The tri-axial accelerometer is used to measure step events and to estimate step stride. Due to magnetic disturbance indoor and gyroscope drift error, we propose a quaternion-based extended Kalman filter (EKF) for heading estimation by combining the magnetometer data and gyroscope data. Because of their complementary characteristics, a better accuracy in the heading solution is got.
Analysis of a Drosophila cyclin E Hypomorphic Mutation Suggests a Novel Role for Cyclin E in Cell Proliferation Control During Eye Imaginal Disc Development (1998)

We have generated and characterized a Drosophila cyclin E hypomorphic mutation, DmcycEJP, that is homozygous viable and fertile, but results in adults with rough eyes. The mutation arose from an internal deletion of an existing P[w+lacZ] element inserted 14 kb upstream of the transcription start site of the DmcycE zygotic mRNA. The presence of this deleted P element, but not the P[w+lacZ] element from which it was derived, leads to a decreased level of DmcycE expression during eye imaginal disc development. Eye imaginal discs from DmcycEJP larvae contain fewer S phase cells, both anterior and posterior to the morphogenetic furrow. This results in adults with small rough eyes, largely due to insufficient numbers of pigment cells. Altering the dosage of the Drosophila cdk2 homolog, cdc2c, retinoblastoma, or p21(CIP1) homolog dacapo, which encode proteins known to physically interact with Cyclin E, modified the DmcycEJP rough eye phenotype as expected. Decreasing the dosage of the S phase transcription factor gene, dE2F, enhanced the DmcycEJP rough eye phenotype. Surprisingly, mutations in G2/M phase regulators cyclin A and string (cdc25), but not cyclin B1, B3, or cdc2, enhanced the DmcycEJP phenotype without affecting the number of cells entering S phase, but by decreasing the number of cells entering mitosis. Our analysis establishes the DmcycEJP allele as an excellent resource for searching for novel cyclin E genetic interactors. In addition, this analysis has identified cyclin A and string as DmcycEJP interactors, suggesting a novel role for cyclin E in the regulation of Cyclin A and String function during eye development.
Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis (1993)

We performed yearly MRI analyses on 327 of the total 372 patients in a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-1b (IFNB). Clinical results are presented in the preceding companion paper. Baseline MRI characteristics were the same in all treatment groups. Fifty-two patients at one center formed a cohort for frequent MRIs (one every 6 weeks) for analysis of disease activity. The MRI results support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans (median 80% reduction, p = 0.0082) and appearance of new lesions. In addition, there was an equally significant reduction in MRI-detected burden of disease in the treatment as compared with placebo groups (mean group difference of 23%, p = 0.001). These results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients.
Cytotoxic activity of rheumatoid and normal lymphocytes against allogeneic and autologous synovial cells in vitro. (1976)

The possibility that lymphocytes from patients with rheumatoid arthritis (RA) might be sensitized to RA synovial cell antigens was investigated with a 51Cr release cytotoxicity assay. Peripheral blood lymphocytes from rheumatoid and normal donors were tested for cytotoxic activity against their own synovial cells and against allogeneic rheumatoid and nonrhemuatoid synovial cells. In the allogeneic studies, the degree of cytotoxicity was significantly influenced by the age in culture (passage number) of the synovial target cells (P less than 0.001). When the passage number of the target cells was considered in the analysis, rheumatoid lymphocytes were found to have greater cytotoxic activity than normal lymphocytes against young cultures (low passage number) of both RA and non-RA synovial cells (P = 0.0042). Differences in susceptibility to lysis between RA and non-RA synovial cells were more susceptible to both RA and normal lymphocyte-induced lysis than were non-RA synovial cells (P = 0.0048). No evidence of cytotoxicity was detected when lymphocytes from nine RA patients and two osteoarthritis patients were reacted against their own synovial cells. Although the data demonstrated an increased cytotoxic activity of peripheral blood lymphocytes from some RA patients against allogeneic synovial cells, the fact that this reactivity was seen against both non-RA and RA synovial cells and was not demonstrated against autologous synovial cells argues against the presence of an immunospecific response of RA lymphocytes to RA synovial cell antigens.
Conservation of Function and Regulation within the Cdc28 /cdc2 Protein Kinase Family: Characterization of the Human Cdc2Hs Protein Kinase in Saccharomyces cerevisiae (1989)

Whereas the Cdc28 protein kinase of the budding yeast Saccharomyces cerevisiae plays an essential role in cell cycle progression during the G1 interval, a function in the progression from the G2 interval into M phase has been inferred for its homologs, including the Cdc2Hs protein kinase of humans. To better understand these apparently disparate roles, we constructed a yeast strain in which the resident CDC28 gene was replaced by its human homolog, CDC2Hs. This transgenic yeast strain was able to perform the G1 functions attributed to the Cdc28 protein kinase, including the ability to grow and divide normally, to respond to environmental signals that induce G1 arrest, and to regulate the Cdc2Hs protein kinase appropriately in response to these signals.
Predictors of school readiness in five‐ to six‐year‐old children from an Australian longitudinal community sample (2010)

This paper reports on school readiness (SR) and its predictors in five‐ to six‐year‐old children from a prospective, longitudinal study of children from eight months to seven years (the Early Language in Victoria Study – ELVS). The ELVS children came from a representative sample of children recruited though the State Government Infant and Child Health Centres at the age of eight months who were studied at yearly intervals with a combination of parent surveys and face‐to‐face assessments. The study had a focus on language, pre‐literacy and behavioural development. In pre‐school and preparatory grade, teachers of the children completed a brief questionnaire rating SR characteristics, including cognitive, language and personal/social competencies. The data bank on these children provided a set of hypothesised child and family predictors of the SR score which were tested via factor analysis and regression analyses. Significant predictors of SR in the equation were evident from two years of age, and were all related to language and pre‐literacy factors from two to six years. Twelve per cent of the children showed language impairment (LI) at five years according to their scores on the Clinical Evaluation of Language Fundamentals, 4th edition (CELF‐4). In an additional analysis we found that these children were significantly lower on SR; they were also of lower social class compared with the remainder of the sample. The most influential factors in readiness for school were child language competencies and pre‐literacy capacities, including phonemic awareness and letter knowledge. Preparation for school involving systematic emphasis on language and pre‐literacy enrichment is recommended for all children before school entry and particularly for children at risk, including those coming from socio‐economic disadvantage and those with delayed and impaired early language development. This addition to pre‐school programmes can have lasting positive effects into pre‐school and beyond, and prevent early school failure.
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation (1999)

The inhibitor of apoptosis (IAP) proteins form a highly conserved gene family that prevents cell death in response to a variety of stimuli. Herein we describe a newly defined murine IAP, designated Tiap, that proved to be a murine homologue of human survivin based on sequence comparison. TIAP has one baculovirus IAP repeat and lacks a C-terminal RING finger motif. TIAP interacted with the processed form of caspase 3 and inhibited caspase-induced cell death. Histological examinations revealed that TIAP is expressed in growing tissues such as thymus, testis, and intestine of adult mice and many tissues of embryos. In in vitro studies, TIAP was induced in splenic T cells activated with anti-CD3 antibody or Con A, and the expression of TIAP was up-regulated in synchronized NIH 3T3 cells at S to G2/M phase of the cell cycle. We propose that during cell proliferation, cellular protective activity may be augmented with inducible IAPs such as TIAP.
LINEARIZED INVERSION OF SEISMIC REFLECTION DATA* (1984)

A bstract This is the first of a series of papers giving the solution of the inverse problem in seismic exploration. The acoustic approximation is used together with the assumption that the velocity field has the form image . The forward problem is then linearized (thus neglecting multiple reflected waves) and the inverse problem of estimating δ is set up. Its rigorous solution can be obtained using an iterative algorithm, each step consisting of a classical Kirchhoff migration (hyperbola summation) plus a classical forward modeling step (circle summation).
LIVE ATTENUATED VARICELLA VACCINE (1996)

Varicella-zoster virus (VZV) is a ubiquitous human pathogen that causes varicella, commonly called chicken pox; establishes latency; and reactivates as herpes zoster, referred to as shingles. A live attenuated varicella vaccine, derived from the Oka strain of VZV has clinical efficacy for the prevention of varicella. The vaccine induces persistent immunity to VZV in healthy children and adults. Immunization against VZV also has the potential to lower the risk of reactivation of latent virus. The varicella vaccine may eventually reduce or eliminate herpes zoster, which is a serious problem for elderly and immunocompromised individuals.
Involvement of Rho‐kinase in hypertensive vascular disease —a novel therapeutic target in hypertension (2001)

ABSTRACT Intracellular signaling pathway mediated by Rho/Rho‐kinase plays an important role in the regulation of vascular smooth muscle contraction and other cellular functions, including adhesion, migration, proliferation, and hypertrophy. A Rho‐kinase inhibitor has been shown to lower blood pressure in hypertensive rats in vivo , however, direct evidence for the involvement of Rho‐kinase in hypertensive vascular disease is still lacking. In this study, we tested our hypothesis that Rho‐kinase is involved substantially in functional and structural alterations of hypertensive blood vessels in spontaneously hypertensive rats (SHR). Force measurement with isolated blood vessels demonstrated that Rho‐kinase was involved significantly in the vascular hyperreactivity in SHR. Biochemical analysis showed that both the expression and the activity of Rho‐kinase were augmented in blood vessels of SHR. It is important to note that the involvement of Rho‐kinase in the vascular hyperreactivity preceded the development of hypertension. Finally, long‐term blockade of Rho‐kinase suppressed vascular lesion formation such as medial hepertrophy and perivascular fibrosis in SHR. Our results provide the first evidence that augmented expression and function of Rho‐kinase plays a key role in the pathogenesis of hypertensive vascular disease, which suggests that this molecule could be regarded as a novel therapeutic target in hypertension.
CR2 ligands modulate human B cell activation. (1988)

A considerable body of evidence from this and other laboratories indicates that complement receptor type 2 (CR2) modulates B cell activation and growth. In the present studies we have examined the effects of three different types of CR2 ligands, i.e., monomeric, aggregated, and latex-bound C3dg; mAb to different CR2 epitopes; and UV-inactivated, non-transforming EBV (EBVUV) for their actions on highly purified, high density resting tonsil B cells. Although none of these ligands induced B cells to enter the cell cycle or synergized with either anti-mu or low m.w. B cell growth factor in triggering B cell mitogenesis, aggregated C3dg, latex-bound C3dg, the OKB7 anti-CR2 mAb, and EBVUV-enhanced thymidine incorporation by phorbol ester-activated tonsil B cells. Such enhancement was not T cell or monocyte dependent. The major action of the CR2 ligands thus seems to be to enhance the transition of B cells activated by certain stimuli from the G1 to the S phase of the cell cycle. In contrast to the action of aggregated and latex-bound C3dg, monomeric C3dg was inhibitory for phorbol ester and aggregated C3dg-induced B cell activation. The HB-5 anti-CR2 mAb, which reacts with a different epitope on CR2 from that of OKB7, did not synergize with PMA in B cell activation. These data provide additional evidence for a role for the CR2 in the control of B cell growth and provide a useful model for studying the CR2-mediated signals that affect the growth of B cells.
Expression cloning of a rat brain somatostatin receptor cDNA. (1992)

We have used an expression-cloning strategy to isolate a cDNA encoding a somatostatin (somatotropin release-inhibiting factor, SRIF) receptor from rat cortex and hippocampus. A positive clone was identified by autoradiography after binding of radiolabeled SRIF to COS-1 cells previously transfected with pools of cDNA clones. The deduced amino acid sequence of the receptor displays sequence and structural homology to the family of G-protein-coupled receptors. The affinity of various SRIF analogs to the expressed receptor resembles their effects on growth hormone release from pituitary cells. In addition, the distribution of the mRNA in various tissues corresponds to that described for native SRIF receptors. Therefore, we conclude that we have isolated a rat brain SRIF receptor cDNA.
Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating αvβ5 vitronectin receptor cell surface expression (2002)

We have previously shown that urokinase receptor physically and functionally interacts with alpha(v)beta5 vitronectin receptor, leading to tumor breast cell migration and invasion. Here, the link between these 2 receptors was further investigated by analyzing the expression levels of urokinase receptor and alpha(v)beta5 integrin in 35 human breast carcinomas and 5 benign breast lesions. The occurrence of a positive correlation between urokinase receptor and alpha(v)beta5 protein levels in benign and malignant tumor specimens prompted us to investigate whether engaged urokinase receptors might modulate alpha(v)beta5 expression. Here, we report the receptor-dependent ability of catalytically inactive urokinase to upregulate the alpha(v) and beta5 chains in MDA-MB-231 and MCF-7 breast carcinoma cell lines in a time- and concentration-dependent manner. This effect is dependent on protein kinase C activity and requires new protein synthesis. Accordingly, the availability of assembled alpha(v)beta5 receptors on the cell surface increases upon urokinase treatment, as shown by immunoprecipitation and immunocytochemical analyses. Exposure to urokinase leads to enhanced tumor cell migration and invasion, which is prevented by the "phosphorylation-like" urokinase receptor antagonist His-uPA(138E/303E), the DNA-binding drug mithramycin, the protein kinase C inhibitor calphostin C and anti-alpha(v)beta5 antibodies. Finally, urokinase enables benign breast MCF-10A cells to cross Matrigel in a alpha(v)beta5- and urokinase receptor-dependent manner, indicating that urokinase controls a regulatory circuitry crucial to breast tumor progression.
Theoretical and practical ruggedness of UK teletext transmission (1979)

The parameters defining the UK teletext transmission standard were set in 1974 after some two years of intensive theoretical and practical investigations. There were available a multitude of possible combinations of binary signalling schemes, screen formats, character coding and control-coding methods. Many possibilities were assessed before a final choice was made in favour of the 40character × 24row fixed-format synchronous transmission system of the UK teletext specification. The paper discusses the reasons behind the selection of the many parameters defining the UK teletext standard, and why in particular a free-format composite character coding scheme is rejected as quite unsuitable for a broadcast data service. Teletext has been available as a public service in the UK for several years. The soundness of the UK teletext standard is being affirmed by the increasing thousands of viewers who, with a teletext receiver bought at low additional teletext cost, are now enjoying a reliable, error-free, efficient and effective domestic information service.
High frequency of fibroblast growth factor (FGF) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8. (1998)

Fibroblast growth factor (FGF) 8, also known as androgen-induced growth factor, was originally isolated from an androgen-dependent mouse mammary Shionogi carcinoma SC-3 cell line, in which it was shown to have androgen-regulated properties. We previously demonstrated that Fgf 8 transcripts were detected in several human prostate and breast cancer cell lines and that recombinant FGF 8 was mitogenic to an androgen-sensitive prostate cancer LNCaP cell line. In this study, to characterize the roles of FGF 8 in clinical hormone-responsive cancers, we established a monoclonal antibody against FGF 8. In Western blots, this antibody specifically interacted with a FGF 8b isoform that was identical between mouse and human but was not identical to other murine 8a and 8c isoforms. In a cell growth assay using SC-3 cells, the newly established anti-FGF 8 antibody blocked androgen- and FGF 8-stimulated growth but not basic FGF-stimulated growth. Immunohistochemical analyses by use of the established anti-FGF 8 antibody demonstrated that FGF 8 was frequently expressed in human prostate cancers, appearing in 40 of 43 cases (93%), whereas both prostatic hyperplasia specimens and normal prostate tissues included in biopsy specimens were negative for FGF 8 expression. On the other hand, FGF 8 was detected in normal ductal and lobular epithelial cells in breast tissues. FGF 8 was also frequently expressed in various breast diseases, including fibroadenomas (5 of 5 cases, 100%), intraductal papillomas (3 of 3 cases, 100%), ductal hyperplasias (3 of 6 cases, 50%), and breast cancers (8 of 12 cases, 67%). Androgen receptors were also immunohistochemically detected in FGF 8-positive prostate cancers (40 of 40 cases, 100%) and FGF 8-positive breast diseases (17 of 19 cases, 89%). These findings strongly suggest that FGF 8 is involved in hormone-related tumorigenesis of the prostate and breast.
Metabolic control of recombinant protein N‐glycan processing in NS0 and CHO cells (2001)

Chinese hamster ovary and murine myeloma NS0 cells are currently favored host cell types for the production of therapeutic recombinant proteins. In this study, we compared N-glycan processing in GS-NS0 and GS-CHO cells producing the same model recombinant glycoprotein, tissue inhibitor of metalloproteinases 1. By manipulation of intracellular nucleotide-sugar content, we examined the feasibility of implementing metabolic control strategies aimed at reducing the occurrence of murine-specific glycan motifs on NS0-derived recombinant proteins, such as Galalpha1,3Galbeta1,4GlcNAc. Although both CHO and NS0-derived oligosaccharides were predominantly of the standard complex type with variable sialylation, 30% of N-glycan antennae associated with NS0-derived TIMP-1 terminated in alpha1,3-linked galactose residues. Furthermore, NS0 cells conferred a greater proportion of terminal N-glycolylneuraminic (sialic) acid residues as compared with the N-acetylneuraminic acid variant. Inclusion of the nucleotide-sugar precursors, glucosamine (10 mM, plus 2 mM uridine) and N-acetylmannosamine (20 mM), in culture media were shown to significantly increase the intracellular pools of UDP-N-acetylhexosamine and CMP-sialic acid, respectively, in both NS0 and CHO cells. The elevated UDP-N-acetylhexosamine content induced by the glucosamine/uridine treatment was associated with an increase in the antennarity of N-glycans associated with TIMP-1 produced in CHO cells but not N-glycans associated with TIMP-1 from NS0 cells. In addition, elevated UDP-N-acetylhexosamine content was associated with a slight decrease in sialylation in both cell lines. The elevated CMP-sialic acid content induced by N-acetylmannosamine had no effect on the overall level of sialylation of TIMP-1 produced by both CHO and NS0 cells, although the ratio of N-glycolylneuraminic acid:N-acetylneuraminic acid associated with NS0-derived TIMP-1 changed from 1:1 to 1:2. These data suggest that manipulation of nucleotide-sugar metabolism can promote changes in N-glycan processing that are either conserved between NS0 and CHO cells or specific to either NS0 cells or CHO cells.
Norepinephrine in Depressive Reactions (1965)

<h3>Introduction</h3> LITTLE IS known about the possible etiological biochemical factors relating to depressive reactions. Clinical evidence suggests that many depressions respond to the following somatic treatment: electric convulsive therapy (ECT), the imipramine type of drugs, and the monoamine oxidase inhibitor group of drugs.<sup>2,3</sup>Do these two classes of drugs have common factors in their mechanism of action and can this be related to the fact that one antihypertensive agent, namely, reserpine, produces severe depression in a small but consistent number of hypertensive patients?<sup>4-8</sup> Rosenblatt et al,<sup>9</sup>in 1959, were among the first to specifically suggest that changes in brain norepinephrine (NEP) may be involved in depression. Based in part on the knowledge of the effect of reserpine and monoamine oxidase inhibitors on depressed mood and norepinephrine (NEP), they hypothesized that the depressive state might be associated with a relative decrease of norepinephrine