gebhart/patrepeval huggingface dataset:
Efficient memory-based learning for robot control (2021)

This dissertation is about the application of machine learning to robot control. A system which has no initial model of the robot/world dynamics should be able to construct such a model using data received through its sensors—an approach which is formalized here as the SAB (State-Action-Behaviour) control cycle. A method of learning is presented in which all the experiences in the lifetime of the robot are explicitly remembered. The experiences are stored in a manner which permits fast recall of the closest previous experience to any new situation, thus permitting very quick predictions of the effects of proposed actions and, given a goal behaviour, permitting fast generation of a candidate action. The learning can take place in high-dimensional non-linear control spaces with real-valued ranges of variables. Furthermore, the method avoids a number of shortcomings of earlier learning methods in which the controller can become trapped in inadequate performance which does not improve. Also considered is how the system is made resistant to noisy inputs and how it adapts to environmental changes. A well founded mechanism for choosing actions is introduced which solves the experiment/perform dilemma for this domain with adequate computational efficiency, and with fast convergence to the goal behaviour. The dissertation explains in detail how the SAB control cycle can be integrated into both low and high complexity tasks. The methods and algorithms are evaluated with numerous experiments using both real and simulated robot domains. The final experiment also illustrates how a compound learning task can be structured into a hierarchy of simple learning tasks.
The Pathophysiology of the Anterior Tibial Compartmental Syndrome (1975)

Based on a clinical review of 45 patients with acute anterior tibial ischemia, four different conditions were identified. Three were related to increased pressure within the compartment and were called anterior compartmental syndromes. They followed exercise, trauma, and ischemia. The fourth entity was anterior tibial ischemia due to anterial occlusion. An experimental investigation demonstrated that increased pressure within the anterior compartment slows blood flow to the enclosed tissues.
A Novel Human β1,3-N-Acetylgalactosaminyltransferase That Synthesizes a Unique Carbohydrate Structure, GalNAcβ1-3GlcNAc (2004)

We found, using a BLAST search, a novel human gene (GenBank trade mark accession number BC029564) that possesses beta3-glycosyltransferase motifs. The full-length open reading frame consists of 500 amino acids and encodes a typical type II membrane protein. This enzyme has a domain containing beta1,3-glycosyltransferase motifs, which are widely conserved in the beta1,3-galactosyltransferase and beta1,3-N-acetylglucosaminyltransferase families. The putative catalytic domain was expressed in human embryonic kidney 293T cells as a soluble protein. Its N-acetylgalactosaminyltransferase activity was observed when N-acetylglucosamine (GlcNAc) beta1-O-benzyl was used as an acceptor substrate. The enzyme product was determined to have a beta1,3-linkage by NMR spectroscopic analysis, and was therefore named beta1,3-N-acetylgalactosaminyltransferase-II (beta3GalNAc-T2). The acceptor substrate specificity of beta3GalNAc-T2 was examined using various oligosaccharide substrates. Galbeta1-3(GlcNAcbeta1-6)GalNAcalpha1-O-para-nitrophenyl (core 2-pNP) was the best acceptor substrate for beta3GalNAc-T2, followed by GlcNAcbeta1-4GlcNAcbeta1-O-benzyl, and GlcNAcbeta1-6GalNAcalpha1-O-para-nitrophenyl (core 6-pNP), among the tested oligosaccharide substrates. Quantitative real time PCR analysis revealed that the beta3Gal-NAc-T2 transcripts was restricted in its distribution mainly to the testis, adipose tissue, skeletal muscle, and ovary. Its putative orthologous gene, mbeta3GalNAc-T2, was also found in a data base of mouse expressed sequence tags. In situ hybridization analysis with mouse testis showed that the transcripts are expressed in germ line cells. beta3GalNAc-T2 efficiently transferred GalNAc to N-glycans of fetal calf fetuin, which was treated with neuraminidase and beta-galactosidase. However, it showed no activity toward any glycolipid examined. Although the GalNAcbeta1-3GlcNAcbeta1-R structure has not been reported in humans or other mammals, we have discovered a novel human glycosyltransferase producing this structure on N- and O-glycans.
VH gene usage by family members affected with chronic lymphocytic leukaemia (1999)

The excess risk of chronic lymphocytic leukaemia (CLL) in the first-degree relatives of affected patients suggests that familial CLL might constitute a useful model to study the pathogenesis of this disease, as has been demonstrated in numerous other neoplastic disorders. Previous studies have shown non-random utilization of immunoglobulin genes in CLL, some germline in sequence and others containing numerous somatic mutations. To investigate whether familial cases of CLL exhibit similarities in the composition of the B-cell receptor repertoire to the pattern expressed by CLL patients as a whole, we have studied 25 CLL patients belonging to 12 different families (four French and eight Italian), each of which contained at least two affected members. Among familial cases, VH gene segment utilization proved non-random and diverged from the frequencies previously reported among unrelated patients with CLL. Specifically, although the 4-34 and 5-51 gene segments were found repeatedly, the 1-69 and 4-39 gene segments were used sparingly and the 3-23 gene segment presented with increased frequency. Following the pattern detected in studies of unrelated patients, the single 1-69 expressing CLL contained an unmutated H chain sequence and included a long HCDR3 interval. In contrast, 3-23 containing H chains all used JH4, retained at most 93% homology with germline sequence, and included only short HCDR3 intervals. The vast majority of the CLL variable domains contained a high degree of somatic mutation and exhibited an excess of replacement mutations in the CDR intervals. These findings suggest that familial CLL cases may preferentially derive from B-cell progenitors that have responded to antigen.
Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and antiinflammatory activity of some nonacidic trisubstituted imidazolesJoseph G. Lombardino and Edward H. WisemanCite this: J. Med. Chem. 1974, 17, 11, 1182–1188Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jm00257a011https://doi.org/10.1021/jm00257a011research-articleACS PublicationsRequest reuse permissionsArticle Views1076Altmetric-Citations262LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficient, automatic web resource harvesting (2006)

There are two problems associated with conventional web crawling techniques: a crawler cannot know if all resources at a non-trivial web site have been discovered and crawled ("the counting problem") and the human-readable format of the resources are not always suitable for machine processing ("the representation problem"). We introduce an approach that solves these two problems by implementing support for both the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH) and MPEG-21 Digital Item Declaration Language (DIDL) into the web server itself. We present the Apache module "mod_oai", which can be used to address the counting problem by listing all valid URIs at a web server and efficiently discovering updates and additions on subsequent crawls. Our experiments indicated comparable performance for initial crawls, and dramatic increases in update speed mod_oaican also be used to address the representation problem by providing "preservation ready" versions of web resources aggregated with their respective forensic metadata in MPEG-21 DIDL format.
Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members (1996)

E2F is a family of transcription factors implicated in the regulation of genes required for progression through G1 and entry into the S phase. The transcriptionally active forms of E2F are heterodimers composed of one polypeptide encoded by the E2F gene family and one polypeptide encoded by the DP gene family. The transcriptional activity of E2F/DP heterodimers is influenced by association with the members of the retinoblastoma tumor suppressor protein family (pRb, p107, and p130). Here the intracellular distribution of E2F and DP proteins was investigated in transiently transfected Chinese hamster and human cells. In transfected cells, DP-1 did not accumulate in the nucleus unless it was coexpressed with the heterodimeric partners E2F-1, E2F-2, or E2F-3. Domain mapping experiments showed that regions of E2F-1 and DP-1 that are required for stable association of the two proteins were also required for nuclear localization of DP-1. Unlike E2F-1, -2, and -3, E2F-4 did not accumulate in the nucleus unless it was coexpressed with DP-2, p107 and p130, but not pRb, stimulated nuclear localization of E2F-4, either alone or in combination with DP-2. These results indicate that DP proteins preferentially associate with specific E2F partners, and suggest that the ability of specific E2F/DP heterodimers to localize in the nucleus contributes to the regulation of E2F activity.
Noncytotoxic IgE-Mediated Release of Histamine and Serotonin from Murine Mastocytoma Cells (1977)

Cultured murine mastocytoma (AB-CBF1-MCT-1) cells were stimulated to release endogenous or incorporated histamine or serotonin by an IgE-mediated mechanisms without loss of viability. Stimulation was achieved by incubation of the cells with rat IgE-anti-IgE, rat IgE-anti-light chain, fluoresceinated rat IgE-anti-fluorescein, IgE-enriched mouse anti-ovalbumin-ovalbumin, or covalently linked dimers of rat IgE, at doses similar to those optimal for normal peritoneal mast cells. Active cell metabolism and Ca++ were required to obtain release. Despite the latter, no dose of the calcium ionophore, A23187, could be found which caused release without concomitant cytotoxicity. Phosphatidylserine did not enhance release.
Effective-medium theory of zeroth-order lamellar gratings in conical mountings (1993)

A formalism is presented for calculating the ordinary and extraordinary refractive indices for a uniaxial film with optical properties equivalent to those of a conically mounted zeroth-order lamellar grating. In the quasi-static limit (grating-period-to-wavelength ratio → 0) this treatment is exact for both dielectric and metallic gratings. For period-to-wavelength ratios approaching unity, the effective anisotropic refractive indices are dependent on the polar and azimuthal incidence angles. The validity of this method as the period-to-wavelength ratio increases is studied by comparison of the method with the predictions of rigorous grating theories. Comparisons are then made with the predictions of other effective-medium theories. Examples of the use of this theory for conically mounted zeroth-order gratings are presented.
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. (1990)

Coordinate loss of one copy of the p53 gene and mutation of the remaining copy occur in colorectal carcinomas and in many other human malignancies. However, the prevalence of p53 gene mutations in carcinomas which maintain both parental copies of p53 has not previously been evaluated. Moreover, it is not known whether p53 gene mutations are limited to malignant tumors or whether they can also occur in benign neoplasms. To answer these questions, a total of 58 colorectal tumors have been examined; in each tumor, allelic losses were assessed using restriction fragment length polymorphisms and p53 gene mutations were assessed by sequencing cloned polymerase chain reaction products. The following conclusions emerged: (a) p53 gene mutations occurred but were relatively rare in adenomas, regardless of size and whether the adenomas were derived from patients with familial adenomatous polyposis; (b) In carcinomas as well as in adenomas, p53 gene mutations were infrequently observed in tumors which contain both copies of chromosome 17p (17% of 30 tumors), while tumors which lost one copy of chromosome 17p usually had a mutation in the remaining p53 allele (86% of 28 tumors); (c) p53 gene mutations were found at similar frequencies in primary tumor samples and in cell lines derived from tumors. These and other data suggest that the rate limiting step in p53 inactivation is point mutation and that once a mutation occurs, loss of the remaining wild-type allele rapidly follows. Both mutations and allelic losses generally occur near the transition from benign to malignant growth, and the p53 gene may play a causal role in this progression.
Trägerkatalysatoren aus C12‐allylnickel(II)‐komplexen [Ni(C12H19)]X (X = SbF6, O3SCF3) und amorphem aluminiumfluorid in toluol als modell‐katalysatoren für das technische katalysatorsystem Ni(octanoat)2/BF3·OEt2/AlEt3 zur 1,4‐cis‐polymerisation des butadiens (1993)

Abstract The η 3 , η 2 , η 2 ‐dodeca‐2( E ), 6( E ), 10( Z )‐trien‐1‐yl‐nickel(II) complexes [Ni(C 12 H 19 )]X (X = SbF 6 , O 3 SCF 3 ) were treated in toluene with amorphous aluminium trifluoride (which was prepared from AlEt 3 and BF 3 · OEt 2 ) in a mole ratio 1 : 10 to 20, forming a highly active catalyst for the 1,4‐ cis polymerization of butadiene. This catalyst is comparable in its activity and selectivity, and in the molar mass distribution of the polybutadiene, with the technical nickel catalyst Ni(O 2 CR) 2 /BF 3 ċOEt 2 /AlE 3 developed by Bridgestone Tire Company thirty years ago. The existence of the C 12 ‐allynickel(II) cation [Ni(C 12 H 19 )] + on the AlF 3 support could be proved by FAB mass spectroscopic measurements. In agreement with our reaction model for the allyl nickel complex catalyzed butadiene polymerization, it is concluded that the technical nickel catalyst in its effective structure can be described as a polybutadienylnickel(II) complex co‐ordinated to a polymeric fluoroaluminate anion via a fluoride bridge.
METABOLISM OF PURINE NUCLEOSIDE ANALOGS. (1965)

Summary A study was made of the cleavage of ribosides and 2′-deoxyribosides of thioguanine, adenine, and 6-mercaptopurine in mouse tissues. Evidence indicated that this was a phosphorylytic cleavage. Changes in the sugar moiety from ribose or 2′-deoxyribose to xylose, arabinose, 3′-deoxyribose, 5′-deoxyallose or 6′-deoxyallose prevented the cleavage. A shift in the ribosidic linkage from position 9 to 7 of the purine prevented cleavage, as did esterification of the ribose moiety with acetyl or propyl groups. The nucleoside phosphorylase was found to be active on both α- and β-anomers of 2′-deoxythioguanosine and 2′-deoxyribosyl-6-mercaptopurine. The relative rates of cleavage of these anomers varied with the tissue source. The adenosine deaminase of mouse tissues was active on β-anomers, but not on α-anomers. Various changes in the sugar moiety of adenosine decreased or abolished the adenosine deaminase activity. The Km9s were determined for ribosyl, arabinosyl and xylosyl adenine. The substrate affinity was of a higher order for ribosyl adenine. As a result, it was demonstrated that ribosyl adenine could be used in combination with xylosyl or arabinosyl adenine to protect the latter two analogs from the adenosine deaminase of mouse blood, so that they were able to reach subcutaneous tumors via the circulation and produce some inhibitory effects not otherwise possible.
On the potential clinical relevance of the length of arousals from sleep in patients with obstructive sleep apnea. (2006)

Individuals with obstructive sleep apnea experience frequent respiratory event associated cortical arousals, many of which are greater than 15 seconds in duration. These longer arousals, which, in this study, constituted 18.4% of all arousals and accounted for 37.5% of the total arousal time, correlate more closely with the ESS than does the frequency or time attributable to the more numerous brief arousals. This suggests that these more-prolonged arousal events may have a greater impact on the restorative aspect of sleep, or on the perception thereof.
Morphological Control of Catalytically Active Platinum Nanocrystals (2006)

Activity revived: Platinum nanoparticles (cuboctahedra, cubes, and porous particles, see picture, from left to right) capped with alkylammonium ions are synthesized by manipulating the reduction kinetics. The catalytic activity of these nanoparticles is superior to that of nanoparticles whose shape was controlled with a polymeric capping agent and foreign metal ions. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603068_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Eine einfache Synthese der Shikimisäure (1967)

Abstract Das synthetisch leicht zugängliche racem. Triacetat des 4‐Epishikimisäure‐methylesters wird durch flüssigen Fluorwasserstoff zu 80% in racem. Shikimisäure umgewandelt. Die Spaltung der racemischen Verbindungen in die optischen Antipoden wird beschrieben. Das Verhalten der optisch aktiven Formen bei der„Fletcher‐Epimerisierung”︁ wird untersucht und erklärt.
Structure and Morphology of Freeze/Thawed PVA Hydrogels (2000)

The structure and morphology of poly(vinyl alcohol) (PVA) gels prepared by repeated cycles of 8 h freezing at −20 °C and 4 h thawing at +25 °C were examined. Long-term morphological changes of such gels were determined upon swelling in water at 37 °C for 6 months. The preparation conditions were examined by varying such parameters as the number of freezing and thawing cycles, the concentration of aqueous solution, and the PVA molecular weight. The overall structure and stability were examined in terms of water content, fractional PVA dissolution, degree of crystallinity, and crystal size distribution. An increase in the number of freezing and thawing cycles served to reinforce existing crystals within the structure. Increased initial concentrations of aqueous PVA solutions resulted in hydrogels that contained initially higher crystallinity and added stability upon swelling. An increase in the PVA molecular weight resulted in crystals of higher lamellar thickness and a broadening of the crystal size distribution due to an increase in PVA chain length. Secondary crystallization was more pronounced for more loosely cross-linked samples. An increase in the free volume and mobility within the network allowed for additional crystallization to proceed during swelling. Overall, freeze/thawed PVA gels of intermediate molecular weight (M̄n = 64 000) and increased number of freezing and thawing cycles showed enhanced stability during swelling at 37 °C for a 6-month period of time demonstrating their appropriateness for long-term biomedical applications.
ODE parameter inference using adaptive gradient matching with Gaussian processes (2013)

Parameter inference in mechanistic models based on systems of coupled differential equations is a topical yet computationally challenging problem, due to the need to follow each parameter adaptation with a numerical integration of the differential equations. Techniques based on gradient matching, which aim to minimize the discrepancy between the slope of a data interpolant and the derivatives predicted from the differential equations, offer a computationally appealing shortcut to the inference problem. The present paper discusses a method based on nonparametric Bayesian statistics with Gaussian processes due to Calderhead et al. (2008), and shows how inference in this model can be substantially improved by consistently sampling from the joint distribution of the ODE parameters and GP hyperparameters. We demonstrate the efficiency of our adaptive gradient matching technique on three benchmark systems, and perform a detailed comparison with the method in Calderhead et al. (2008) and the explicit ODE integration approach, both in terms of parameter inference accuracy and in terms of computational efficiency. 1
Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivo (2007)

The goal of this work is to develop in vivo photoacoustic (PA) flow cytometry (PAFC) for time-resolved detection of circulating absorbing objects, either without labeling or with nanoparticles as PA labels. This study represents the first attempt, to our knowledge, to demonstrate the capability of PAFC with tunable near-infrared (NIR) pulse lasers for real-time monitoring of gold nanorods, Staphylococcus aureus and Escherichia coli labeled with carbon nanotubes (CNTs), and contrast dye Lymphazurin in the microvessels of mouse and rat ears and mesenteries. PAFC shows the unprecedented threshold sensitivity in vivo as one gold nanoparticle in the irradiated volume and as one bacterium in the background of 10(8) of normal blood cells. The CNTs are demonstrated to serve as excellent new NIR high-PA contrast agents. Fast Lymphazurin diffusion in live tissue is observed with rapid blue coloring of a whole animal body. The enhancement of the thermal and acoustic effects is obtained with clustered, multilayer, and exploded nanoparticles. This novel combination of PA microscopy/spectroscopy and flow cytometry may be considered as a new powerful tool in biological research with the potential of quick translation to humans, providing ultrasensitive diagnostics of pathogens (e.g., bacteria, viruses, fungi, protozoa, parasites, helminthes), metastatic, infected, inflamed, stem, and dendritic cells, and pharmacokinetics of drug, liposomes, and nanoparticles in deep vessels (with focused transducers) among other potential applications.