gebhart/patrepeval huggingface dataset:
Influence of Tołpa Peat Preparation on the IgE-induced anaphylactic reactions in mice. (1993)

The ability of Tołpa Peat Preparation (TPP) to affect anaphylactic sensitization and mast cell secretory function was tested in BALB/c mice treated with TPP orally for 12 days. TPP in the doses of 20 and 50 mg/kg/day reduced histamine release from mouse peritoneal mast cells challenged with anti-IgE or concanavalin A in vitro. The treatment of mice with TPP from day 1 to day 12 of immunization with Ovalbumin (OA) absorbed on aluminium hydroxide gel resulted in a decrease of antigen-induced histamine release from mast cells of these mice in vitro and in decreased IgE antibody level in their sera. TPP introduced into OA-immunized mice showing developed IgE antibody response was less effective in decreasing anaphylactic histamine release from mast cells of these mice. In all experiments low doses of TPP used for oral treatment were more effective than high doses in inhibiting anaphylactic events in the mice.
Metal Binding in Tetracyclines. Cobalt(II) and Nickel(II) Complexes1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal Binding in Tetracyclines. Cobalt(II) and Nickel(II) Complexes1W. A. Baker Jr. and Patrick M. BrownCite this: J. Am. Chem. Soc. 1966, 88, 6, 1314–1317Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/ja00958a041https://doi.org/10.1021/ja00958a041research-articleACS PublicationsRequest reuse permissionsArticle Views274Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Notch Signaling, γ-Secretase Inhibitors, and Cancer Therapy (2007)

The Notch signaling pathway represents a critical component in the molecular circuits that control cell fate during development. Aberrant activation of this pathway contributes to tumorigenesis. The role of Notch in human cancer has been highlighted recently by the presence of activating mutations and amplification of Notch genes in human cancer and by the demonstration that genes in the Notch signaling pathway could be potential therapeutic targets. It has become clear that one of the major therapeutic targets in the Notch pathway are the Notch receptors, in which gamma-secretase inhibitors prevent the generation of the oncogenic (intracellular) domain of Notch molecules and suppress the Notch activity. This review article summarizes the biological roles of Notch molecules in cancer development with special emphasis on the promise and challenges in applying gamma-secretase inhibitors as a new line of targeted therapeutic agents.
Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. (1975)

The differentiation in vitro of clonal pluripotent teratocarcinoma cells is reported. The first stage of this process is the formation of simple embryoid bodies which are identical to those found in animals bearing intraperitoneal teratocarcinomas. They consist of an inner core of embryonal carcinoma cells surrounded by a layer of endodermal cells which produce Reichert's membrane. The endodermal cells become apparent shortly after the embryonal carcinoma cells have formed aggregates which are loosely attached to the substratum. One clonal teratocarcinoma line was found to produce complex cystic embryoid bodies in vitro. Following formation of the endodermal cells, extensive differentiation to a wide variety of cell types occurs. There are similarities between the process of embryoid body formation and the early events of differentiation of the mouse embryo.
Quantum Memory Hierarchies: Efficient Designs to Match Available Parallelism in Quantum Computing (2006)

The assumption of maximum parallelism support for the successful realization of scalable quantum computers has led to homogeneous, ``sea-of-qubits'' architectures. The resulting architectures overcome the primary challenges of reliability and scalability at the cost of physically unacceptable system area. We find that by exploiting the natural serialization at both the application and the physical microarchitecture level of a quantum computer, we can reduce the area requirement while improving performance. In particular we present a scalable quantum architecture design that employs specialization of the system into memory and computational regions, each individually optimized to match hardware support to the available parallelism. Through careful application and system analysis, we find that our new architecture can yield up to a factor of thirteen savings in area due to specialization. In addition, by providing a memory hierarchy design for quantum computers, we can increase time performance by a factor of eight. This result brings us closer to the realization of a quantum processor that can solve meaningful problems.
Sleep and Wakefulness Out of Phase with Internal Biological Time Impairs Learning in Humans (2006)

Sleep-wake homeostatic and internal circadian timedependent brain processes interact to regulate human brain function so that alert wakefulness is promoted during the daytime and consolidated sleep is promoted at nighttime. The consequence of chronically altering the normal relationship between these processes for human brain function is largely unknown. We tested cognitive and vigilance performance while subjects lived in the laboratory for over a month. The subjects lived on either 24.0- or 24.6-hr day lengths. Half of the subjects tested maintained a normal relationship between sleep-wakefulness and internal circadian time (synchronized group), whereas the other half did not (nonsynchronized group). Levels of the sleep-promoting hormone melatonin were high during scheduled sleep in the synchronized group, whereas melatonin levels were high during scheduled wakefulness in the nonsynchronized group. Failure to adapt to the scheduled day length was dependent upon individual differences in intrinsic circadian period. Total sleep time was reduced, sleep latency and Rapid Eye Movement (REM) latency were shortened, and wakefulness after sleep onset was increased in the nonsynchronized group. Cognitive performance improved (i.e., learning) in the synchronized group, whereas learning was significantly impaired in the nonsynchronized group. Attention progressively declined in both groups, suggesting that 8 hr of scheduled sleep per night is insufficient to maintain brain vigilance even when sleep occurs at an appropriate biological time. Our results establish that proper alignment between sleep-wakefulness and internal circadian time is crucial for enhancement of cognitive performance. In addition, our results demonstrate that exposure to dim light (approximately 25 lx) is sufficient to expand the range of entrainment in humans.
Refractory Plasmonics with Titanium Nitride: Broadband Metamaterial Absorber (2014)

A high-temperature stable broadband plasmonic absorber is designed, fabricated, and optically characterized. A broadband absorber with an average high absorption of 95% and a total thickness of 240 nm is fabricated, using a refractory plasmonic material, titanium nitride. This absorber integrates both the plasmonic resonances and the dielectric-like loss. It opens a path for the interesting applications such as solar thermophotovoltaics and optical circuits.
A tele-instruction system for ultrasound probe operation based on shared AR technology (2005)

This paper proposes a tele-instruction system for ultrasound probe operation, based on shared Augmented Reality (AR) technology. Telemedicine, a strategy to diminish geographic gaps in the quality of medical service, is fashionable. However, existing medical-data transmission systems cannot convey the skills of physicians, so they cannot eliminate the problem of geographic gaps. This research developed a telemedicine system that transports physicians' skills over a shared AR space. The shared AR technology provides an environment where users can exchange spatial information, and facilitates smooth communication. This research concentrates on interfaces for physicians and technicians at the patient site. The proposed system provides intuitive and unrestricted interfaces for the physician and technician, using a data projector and an LCD tablet. At the patient site, instructions for the technician are projected directly onto the patient's body, using a data projector. The physician site allows the physician to send instructions on probe operation using an LCD tablet. This information is displayed as a "web-mark", which provides spatial information for ultrasound probe operation. Furthermore, the system sends environmental information about the patient to the physician, such as the technician's behavior and patient's posture, via an immersive display. The proposed system was tested with a physician using real tele-diagnosis. The results demonstrated the effectiveness of the proposed method in providing smooth communication in telemedicine.
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers (2017)

Chimeric antigen receptor T (CAR-T) cells have shown promising efficacy in treatment of hematological malignancies, but its applications in solid tumors need further exploration. In this study, we investigated CAR-T therapy targeting carcino-embryonic antigen (CEA)-positive colorectal cancer (CRC) patients with metastases to evaluate its safety and efficacy. Five escalating dose levels (DLs) (1 × 10<sup>5</sup> to 1 × 10<sup>8</sup>/CAR<sup>+</sup>/kg cells) of CAR-T were applied in 10 CRC patients. Our data showed that severe adverse events related to CAR-T therapy were not observed. Of the 10 patients, 7 patients who experienced progressive disease (PD) in previous treatments had stable disease after CAR-T therapy. Two patients remained with stable disease for more than 30 weeks, and two patients showed tumor shrinkage by positron emission tomography (PET)/computed tomography (CT) and MRI analysis, respectively. Decline of serum CEA level was apparent in most patients even in long-term observation. Furthermore, we observed persistence of CAR-T cells in peripheral blood of patients receiving high doses of CAR-T therapy. Importantly, we observed CAR-T cell proliferation especially in patients after a second CAR-T therapy. Taken together, we demonstrated that CEA CAR-T cell therapy was well tolerated in CEA<sup>+</sup> CRC patients even in high doses, and some efficacy was observed in most of the treated patients.
Immunotherapy of human tumors with T-cell-activating bispecific antibodies: stimulation of cytotoxic pathways in vivo. (1999)

Bispecific monoclonal antibodies (Bi-mAbs) specific for a tumor-associated antigen and the CD3 or CD28 antigen on T lymphocytes represent one of the most successful experimental strategies for the immunotherapy of cancer. We report that the in vivo administration of both alpha-CD3/CD30 and alpha-CD28/CD30 Bi-mAbs results in the specific activation of xenotransplanted, resting human T cells infiltrating the CD30-positive Hodgkin's tumor. Bi-mAb treatment resulted in enhanced expression of cytokines such as interleukin 1beta, interleukin 2, tumor necrosis factor type alpha, and activation markers including Ki-67, CD25, and CD45RO in tumor-infiltrating lymphocytes. This antigen-dependent, local T-cell stimulation led to the activation of the cytolytic machinery in T lymphocytes, determined by the up-regulation of mRNA-encoding perforin and the cytotoxic serine-esterases granzymes A and B. The Bi-mAb-induced generation of CTLs depended on the presence of the CD30 antigen and the combined application of both Bi-mAbs. Our findings suggest that the combined application of T-cell-activating Bi-mAbs is able to achieve a tumor site-specific activation of the T-cell cytolytic machinery in vivo. The fact that these cytotoxic cells do not home in tumor-associated antigen-negative tissue and do not enter circulation might explain our previous observations (C. Renner et al., Blood, 87: 2930-2937, 1996) of a high cure rate in preclinical models even at an advanced stage of disease.
Manhattan-world stereo (2009)

Multi-view stereo (MVS) algorithms now produce reconstructions that rival laser range scanner accuracy. However, stereo algorithms require textured surfaces, and therefore work poorly for many architectural scenes (e.g., building interiors with textureless, painted walls). This paper presents a novel MVS approach to overcome these limitations for Manhattan World scenes, i.e., scenes that consists of piece-wise planar surfaces with dominant directions. Given a set of calibrated photographs, we first reconstruct textured regions using an existing MVS algorithm, then extract dominant plane directions, generate plane hypotheses, and recover per-view depth maps using Markov random fields. We have tested our algorithm on several datasets ranging from office interiors to outdoor buildings, and demonstrate results that outperform the current state of the art for such texture-poor scenes.
Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma. (1990)

TNF-alpha and lymphotoxin (LT or TNF-beta) are structurally related cytokines that share several proinflammatory and immunomodulatory activities. The shared biologic activities of TNF and LT have been attributed to their binding to a common cell surface receptor(s). We observed that rTNF enhanced the expression of MHC class I proteins on the human T cell hybridoma, II-23.D7, however LT was largely unable to regulate MHC expression. To determine the molecular basis of this disparity between LT and TNF the receptor binding characteristics of rTNF and rLT were investigated by direct and competitive radioligand assays on the II-23.D7 T hybridoma, and for comparison, anti-CD3 activated human T lymphocytes. Specific 125I-rTNF binding to the II-23.D7 line revealed a single class of sites with a Kd = 175 pM and 3000 sites/cell; anti-CD3 activated T cells exhibited specific TNF binding with similar properties. The relationship of receptor occupancy to the induction of MHC class I Ag yielded a hyperbolic curve indicating a complex relationship between rTNF binding and biologic response. LT appeared to function like a partial agonist in that rLT was 10- to 20-fold less effective than rTNF in competitively inhibiting 125I-rTNF binding on the II-23.D7 line. Scatchard type analysis revealed a single class of low affinity binding sites for 125I-rLT. No differences in the competitive binding activity of rTNF and rLT were observed on the anti-CD3-activated T cells. Receptors for rTNF and rLT were immunoprecipitated from the II-23.D7 and activated T cells with anticytokine antibodies after cross-linking of radioiodinated rTNF or rLT to intact cells by using chemical cross-linking reagents. Analysis of the cross-linked adducts by SDS-PAGE and autoradiography indicated a major adduct of 92 kDa for rTNF and 104 kDa for rLT. Enzymatic digestion with neuraminidase or V8 protease revealed a unique structure to these adducts consistent with the cross-linking of a single chain of cytokine to a cell surface glycoprotein. rTNF inhibited the formation of the 104-kDa adduct formed with 125I-rLT on the II-23.D7 line, indicating these two cytokines bind to the same receptor of approximately 80 kDa. These results suggest that the disparate activities of LT and TNF to induce MHC class I proteins on the II-23.D7 cells are, in part, associated with a modified state of a common receptor.
A facile synthesis of N-phenyl-6-hydroxy-3-bromo-4-arylazo quinolin-2-ones under phase transfer catalytic conditions and studies on their antimicrobial activities (2006)

The synthesis and characterization of N-phcnyl-6-hydroxy-3-bromo-4-arylazoquinolin-2-oncs has been reported under phase transfer catalytic conditions in 70% yields. Interaction of N-phenyl-2,5-dihydroxy-3-alylazo indoles with dibromocarbene under phase transfer catalysis conditions at 50-60°C and 600 r.p.m. results in a cycloaddition of the in situ generated carbene to the C=C bond followed by skeletal rearrangement in the indole frame work to yield quinoline nuclei. The structure of the compounds are established on the basis of their elemental, IR and 1 H NMR and 13 C NMR data. All the synthesized compounds have been evaluated for their in vitro growth inhibitory activity against Eschcrichia coli, Pseudomonas diminuta, Bascillus subtilis, Bacillus megaterium and Staphylococcus aureus. All the compounds show significant antibacterial activity. A perusal of data reveals that molecular refractive index (M R ) is correlated linearly to the drug activity. The synthesized compounds have been subjected to acute toxicity studies to find out LD 50 values. The compounds do not show any toxicity up to dose of 7.5 mg/kg body weights in rats.
Removing electroencephalographic artifacts by blind source separation (2000)

Eye movements, eye blinks, cardiac signals, muscle noise, and line noise present serious problems for electroencephalographic (EEG) interpretation and analysis when rejecting contaminated EEG segments results in an unacceptable data loss. Many methods have been proposed to remove artifacts from EEG recordings, especially those arising from eye movements and blinks. Often regression in the time or frequency domain is performed on parallel EEG and electrooculographic (EOG) recordings to derive parameters characterizing the appearance and spread of EOG artifacts in the EEG channels. Because EEG and ocular activity mix bidirectionally, regressing out eye artifacts inevitably involves subtracting relevant EEG signals from each record as well. Regression methods become even more problematic when a good regressing channel is not available for each artifact source, as in the case of muscle artifacts. Use of principal component analysis (PCA) has been proposed to remove eye artifacts from multichannel EEG. However, PCA cannot completely separate eye artifacts from brain signals, especially when they have comparable amplitudes. Here, we propose a new and generally applicable method for removing a wide variety of artifacts from EEG records based on blind source separation by independent component analysis (ICA). Our results on EEG data collected from normal and autistic subjects show that ICA can effectively detect, separate, and remove contamination from a wide variety of artifactual sources in EEG records with results comparing favorably with those obtained using regression and PCA methods. ICA can also be used to analyze blink-related brain activity.
Estrogen receptor expression of benign breast epithelium and its association with breast cancer. (1994)

We conducted a case-control study of estrogen receptor (ER) and progesterone receptor (PgR) expression in benign breast epithelium from 120 women (51 breast cancer cases and 69 benign disease controls) who underwent breast operations at University Hospital, Syracuse, New York. Benign samples were obtained and processed immunohistochemically for ER and PgR (Abbott, Chicago, IL). Receptor positivity was defined as any nuclear immunostaining. Proportionately more cases than controls were ER positive (84% versus 57%); PgR positivity was similar in cases and controls (86%). Logistic regression yielded an adjusted odds ratio of 6.5 for breast cancer among ER-positive women (95% confidence interval of 1.5 and 27.4); odds ratio of PgR positivity was 0.3 (95% confidence interval of 0.1 and 1.9). Adjustment for known risk factors for breast cancer did not change the odds ratio. ER-positive breast epithelium needs evaluation as a possible risk marker for breast cancer.
Advances in Quantitative Electroencephalogram Analysis Methods (2004)

Quantitative electroencephalogram (qEEG) plays a significant role in EEG-based clinical diagnosis and studies of brain function. In past decades, various qEEG methods have been extensively studied. This article provides a detailed review of the advances in this field. qEEG methods are generally classified into linear and nonlinear approaches. The traditional qEEG approach is based on spectrum analysis, which hypothesizes that the EEG is a stationary process. EEG signals are nonstationary and nonlinear, especially in some pathological conditions. Various time-frequency representations and time-dependent measures have been proposed to address those transient and irregular events in EEG. With regard to the nonlinearity of EEG, higher order statistics and chaotic measures have been put forward. In characterizing the interactions across the cerebral cortex, an information theory-based measure such as mutual information is applied. To improve the spatial resolution, qEEG analysis has also been combined with medical imaging technology (e.g., CT, MR, and PET). With these advances, qEEG plays a very important role in basic research and clinical studies of brain injury, neurological disorders, epilepsy, sleep studies and consciousness, and brain function.
Reassessment of Blood Gene Expression Markers for the Prognosis of Relapsing-Remitting Multiple Sclerosis (2011)

Despite considerable advances in the treatment of multiple sclerosis, current drugs are only partially effective. Most patients show reduced disease activity with therapy, but still experience relapses, increasing disability, and new brain lesions. Since there are no reliable clinical or biological markers of disease progression, long-term prognosis is difficult to predict for individual patients. We identified 18 studies that suggested genes expressed in blood as predictive biomarkers. We validated the prognostic value of those genes with three different microarray data sets comprising 148 patients in total. Using these data, we tested whether the genes were significantly differentially expressed between patients with good and poor courses of the disease. Poor progression was defined by relapses and/or increase of disability during a two-year follow-up, independent of the administered therapy. Of 110 genes that have been proposed as predictive biomarkers, most could not be confirmed in our analysis. However, the G protein-coupled membrane receptor GPR3 was expressed at significantly lower levels in patients with poor disease progression in all data sets. GPR3 has therefore a high potential to be a biomarker for predicting future disease activity. In addition, we examined the IL17 cytokines and receptors in more detail and propose IL17RC as a new, promising, transcript-based biomarker candidate. Further studies are needed to better understand the roles of these receptors in multiple sclerosis and its treatment and to clarify the utility of GPR3 and IL17RC expression levels in the blood as markers of long-term prognosis.