gebhart/patrepeval huggingface dataset:
Flavin-Catalyzed Baeyer−Villiger Reaction of Ketones:  Oxidation of Cyclobutanones to γ Lactones Using Hydrogen Peroxide (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFlavin-Catalyzed Baeyer−Villiger Reaction of Ketones: Oxidation of Cyclobutanones to γ Lactones Using Hydrogen PeroxideClaudio Mazzini, Jacques Lebreton, and Roland FurstossView Author Information Groupe de Chimie Organique et Bioorganique, URA CNRS 1320, Faculté des Sciences de Luminy, Case 901, 163 Avenue de Luminy, 13288 Marseille Cedex 9, France Cite this: J. Org. Chem. 1996, 61, 1, 8–9Publication Date (Web):January 12, 1996Publication History Received26 October 1995Published online12 January 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo951905bhttps://doi.org/10.1021/jo951905brapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1489Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Ketones,Lactones,Oxidation,Oxides Get e-Alerts
Virus-Based Fabrication of Micro- and Nanofibers Using Electrospinning (2004)

Long rod-shaped M13 viruses were used to fabricate one-dimensional (1D) micro- and nanosized diameter fibers by mimicking the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in a cross-linking solution of glutaraldehyde. Resulting fibers were 10−20 μm in diameter. AFM imaging verified that the molecular long axis of the virus fibers was parallel to the fiber long axis. M13 viruses were suspended in 1,1,1,3,3,3-hexafluoro-2-propanol and were then electrospun into fibers. After blending with a highly water soluble polymer, polyvinyl pyrolidone (PVP), M13 viruses were spun into continuous uniform virus-blended PVP (virus-PVP) nanofibers. Resulting virus-PVP electrospun fibers maintained their ability to infect bacterial hosts after resuspending in buffer solution.
Dynamic spatial-temporal changes of forest resources in Xixia county based on RS and GIS (2005)

This article studied on spatial-temporal changes of forest resources in Xixia county, Henan province. By means of IMAGINE software, TM data of 2 years in Xixia county were used for analyzing. Through band combination, image stretching, supervised classification, matrix analysis and recoding, images were ready for GIS analysis and RS image drawing. The result showed that areas of broad-leaf forest and areas of coniferous forest increased from 1998 to 2002, and the increased parts changed from fields and brass lands. It also showed that variables of forests concentrated in low altitude ,and in high altitude variables centralized near roads and rivers.
Receptor for interleukin 13 on AIDS-associated Kaposi's sarcoma cells serves as a new target for a potent Pseudomonas exotoxin-based chimeric toxin protein. (1997)

AIDS-associated Kaposi's sarcoma (AIDS-KS), the most common malignant complication of human immunodeficiency virus infection, is characterized by neoplastic proliferation of mesenchymal cells. AIDS-KS cells release and respond to an array of cytokines through specific plasma membrane receptors. Specific targeting of potent cytotoxic agents to cell surface receptors/antigens on Kaposi's sarcoma cells may provide effective therapy for this malignancy. We have identified a new target in the form of an interleukin 13 (IL-13) receptor that is overexpressed in the five AIDS-KS cell lines examined. Radiolabeled IL-13 cross-linked to a single protein of about Mr 70,000 in AIDS-KS cells. We utilized a chimeric cytotoxic protein composed of IL-13 and a truncated Pseudomonas exotoxin (IL13-PE38QQR), which was found to be specifically and highly cytotoxic to AIDS-KS cells, as determined by protein synthesis inhibition and clonogenic assays. IL13-PE38QQR demonstrated significant antitumor activity in a human epidermoid carcinoma xenograft model. Normal human umbilical vein-derived endothelial, lymphoid, and bone marrow precursor cells expressed low levels of IL-13 receptors, and IL-13 toxin was not cytotoxic to them. Thus, IL-13 receptor on AIDS-KS cells may represent a novel plasma membrane protein(s) that could be utilized to target therapeutic agents.
Design of New Anti-Cancer Agents Based on Topoisomerase Poisons Targeted to Specific DNA Sequences (2001)

There is considerable interest in the development of sequence-selective DNA drugs. Chemical agents able to interfere with DNA topoisomerases - essential nuclear enzymes- are widespread in nature, and some of them have outstanding therapeutic efficacy in human cancer and infectious diseases. Several classes of antineoplastic drugs, such as amsacrine, daunorubicin, etoposide (acting on type II topoisomerases), camptothecin and indolocarbazole derivatives of the antibiotic rebeccamycin (acting on type IB topoisomerases), have been shown to stimulate DNA cleavage by topoisomerases leading to cell death. However, these molecules exhibit little sequence preference. A convenient strategy to confer sequence specificity consists in the attachment of these topoisomerase poisons to sequence-specific DNA binding elements. Among sequence-specific DNA ligands, oligonucleotides can bind with high specificity of recognition to the major groove of double-helical DNA, resulting in triple helix formation. In this context, derivatives of camptothecin, indolocarbazole, anthracycline and acridine poisons have been covalently tethered to triple helix-forming oligonucleotides. The use of triple-helical DNA structures offers an efficient system to target topoisomerase I and II-mediated DNA cleavage to specific sequences and to increase the drug efficacy at these sites. Chemical optimization of the conjugates is essential to the efficacy of drug targeting. Consequently, the rational design of this new class of anti-cancer agents, conceived from topoisomerase poisons and triplex-forming oligonucleotides, may be exploited to improve the efficacy and selectivity of the DNA damage induced by topoisomerases.
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. (1975)

Clonal isolates of mouse 3T3 cells and primary rat embryo cells, recovered nonselectively after infection by simian virus 40 (SV40), have been tested for tumorigenicity in the immune-deficient nude mice in order to determine the cellular growth properties in vitro specifically correlated with neoplastic growth in vivo. In addition, mouse 3T3 cells transformed by murine sarcoma virus (MuSV, Kirsten strain), and revertants isolated from cells fully transformed by either SV40 or MuSV were also studied. Results suggest that the single cellular property consistently associated with tumorigenicity in nude mice is the acquisition by virus-transformed cells of the ability to proliferate in vitro in the absence of anchorage. Other cellular parameters of virus-induced transformation, such as lack of sensitivity to high cell density and the capacity to grow in low serum concentration, are dissociable from cellular tumorigeneicity. This conclusion is supported further by the demonstration that specific selection in vivo for tumorigenic cells from anchorage-dependent cells results in the isolation of anchorage-independent cells. Conversely, a single-step selection in vitro for anchorage-independent cells from nontumorigenic cells results in a simultaneous selection of highly tumorigenic subclones.
Determination of cerebral glucose transport and metabolic kinetics by dynamic MR spectroscopy (1997)

A new in vivo nuclear magnetic resonance (NMR) spectroscopy method is introduced that dynamically measures cerebral utilization of magnetically labeled [1-13C]glucose from the change in total brain glucose signals on infusion. Kinetic equations are derived using a four-compartment model incorporating glucose transport and phosphorylation. Brain extract data show that the glucose 6-phosphate concentration is negligible relative to glucose, simplifying the kinetics to three compartments and allowing direct determination of the glucose-utilization half-life time [t1/2 = ln2/(k2 + k3)] from the time dependence of the NMR signal. Results on isofluorane (n = 5)- and halothane (n = 7)-anesthetized cats give a hyperglycemic t1/2 = 5.10 +/- 0.11 min-1 (SE). Using Michaelis-Menten kinetics and an assumed half-saturation constant Kt = 5 +/- 1 mM, we determined a maximal transport rate Tmax = 0.83 +/- 0.19 mumol.g-1.min-1, a cerebral metabolic rate of glucose CMRGlc = 0.22 +/- 0.03 mumol.g-1.min-1, and a normoglycemic cerebral influx rate CIRGlc = 0.37 +/- 0.05 mumol.g-1.min-1. Possible extension of this approach to positron emission tomography and proton NMR is discussed.
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. (1980)

The sequence of the transforming region of the Moloney murine sarcoma virus genome has been determined by using molecularly cloned viral DNA. This region, 3.6 to 5.8 kilobase pairs from the left end of the molecule, contains the entire cellular insertion (src) sequence as well as helper viral sequences including the large terminal repeat (LTR). On the viral RNA strand, a long (1224 bases) open reading frame commenced to the left of the src-helper virus junction and terminated at a point 58 nucleotides into helper viral sequences to the right of src. Possible promoter and acceptor splice signals were detected in helper viral sequences upstream from this open reading frame. On the antiviral RNA strand, several promoter-like sequences, including one within the src region itself, were identified. However, no open reading frame downstream from these promoters was detected in the antiviral RNA strand. The LTR was found to contain promoter-like sequences as well as LTR was found to contain promoter-like sequences as well as mRNA capping and polyadenylylation signals. In addition, it possessed an 11-base inverted terminal repeat at each end. Thus, the structure of the Moloney murine sarcoma virus genome with an LTR at each end resembles that of prokaryotic transposable elements.
SwiftFile: An Intelligent Assistant for Organizing E-Mail (2000)

While most e-mail clients allow users to file messages into folders, the process they must go through to file each message is often tedious and slow. For each message, the user must first decide which folder is most appropriate. Then, the user must inform the e-mail reader of that choice by selecting the appropriate icon or menu item from among what is typically a set of several dozen choices. The combined effort of choosing a folder and conveying that choice to the application often discourages users from filing their mail, resulting in unmanageable inboxes that contain hundreds or even thousands of unfiled messages. SwiftFile encourages users to file their mail by simplifying the task. Using an adaptive classifier, it predicts the three folders that are most likely to be appropriate for a given message and provides shortcut buttons that permit the user to effortlessly file it into a predicted folder. For typical users, SwiftFile&amp;apos;s predictions are accurate over 80% to...
Nucleic Acids Electrotransfer In Vivo: Mechanisms and Practical Aspects (2010)

Nucleic acids transfer has been steadily improving over the years and is slowly starting to fulfill its long awaited promises. In the beginning, viral approaches raised strong safety concerns that are now answered by various non-viral techniques. Among the physical approaches developed, nucleic acids electrotransfer is probably the one with the highest momentum. Here we review the present knowledge on the mechanistic and practical aspects of in vivo nucleic acids electrotransfer. For each step of this procedure we present different strategies that are used, with their advantages and drawbacks. As we report here, practical solutions have been found to overcome each limiting step in the procedure and to improve its outcome. Some crucial issues are beyond the application of the electric pulses itself, like the administration (i.e., in almost all of the cases, the injection) of the nucleic acids to the tissue or the body. High efficiency and safety are at reach if all the present knowledge and strategies are put to use. Electrotransfer is now a mature technique as proven by the fact that clinical trials using nucleic acids electrotransfer have already started within the past few years.
The role of autolysis loop in determining the specificity of coagulation proteases (2007)

We recently demonstrated that the substitution of the autolysis loop (residues 143 to 154 in the chymotrypsin numbering system) of activated protein C (APC) with the corresponding loop of factor Xa (fXa) renders the APC mutant (APC/fX143-154) susceptible to inhibition by antithrombin (AT) in the presence of pentasaccharide. Our recent results further indicated, that in addition to an improvement in the reactivity of APC/fX143-154 with AT, both the amidolytic and anti-factor Va activities of the mutant APC have also been significantly increased. Since the autolysis loop of APC is five residues longer than the autolysis loop of fXa, it could not be ascertained whether this loop in the mutant APC specifically interacts with the activated conformation of AT or if a shorter autolysis loop is responsible for a global improvement in the catalytic activity of the mutant protease. To answer this question, we prepared another APC mutant in which the autolysis loop of the protease was replaced with the corresponding loop of trypsin (APC/Tryp143-154). Unlike an approximately 500-fold improvement in the reactivity of APC/fX143-154 with AT in the presence of pentasaccharide, the reactivity of APC/Tryp143-154 with the serpin was improved approximately 10-fold. These results suggest that both the length and structure of residues of the autolysis loop are critical for the specificity of the coagulation protease interaction with AT. Further factor Va inactivation studies with the APC mutants revealed a similar role for the autolysis loop of APC in the interaction with its natural substrate.
Synthesis of a controlled three-faced PAMAM particle (2011)

We report the synthetic proof-of-concept for a three-faced particle based on a PAMAM dendrimer in which each face bears a different labile protecting group. This new strategy yields a controlled, well-defined and monodisperse dendrimer. To achieve this, a tri-orthogonal strategy was employed through Sonogashira coupling and Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition (“click” chemistry). The afforded dendrimer is well suited for further development in a variety of fields as each branch can be addressed individually for functionalization.
The dynamics of viral marketing (2007)

We present an analysis of a person-to-person recommendation network, consisting of 4 million people who made 16 million recommendations on half a million products. We observe the propagation of recommendations and the cascade sizes, which we explain by a simple stochastic model. We analyze how user behavior varies within user communities defined by a recommendation network. Product purchases follow a ‘long tail’ where a significant share of purchases belongs to rarely sold items. We establish how the recommendation network grows over time and how effective it is from the viewpoint of the sender and receiver of the recommendations. While on average recommendations are not very effective at inducing purchases and do not spread very far, we present a model that successfully identifies communities, product, and pricing categories for which viral marketing seems to be very effective.
Glycolytic enzyme inhibitor therapy in human malignant neoplasia. (1949)

In a study of the effect of the glycolytic inhibitors fluoride, iodoacetate, and malonate on a series of more than 100 cases of diverse forms of human cancer, it was found that while objective evidence of tumor inhibition was obtained in cases of acute leukemia, Hodgkin's disease, and lymphosarcoma, this was not the case in patients with carcinoma of the colon, fundus uteri, ovary, pancreas, rectum, or in chronic leukemia, melanoma, chorionepithelioma testis, or with squamous cell cancers of the cheek and pharynx. Some responses of a less definitive nature were elicited in cancers of the breast, adrenal cortex, cervix, lung, stomach, and testes. These observations suggest that while certain cancer types behave as if they were particularly dependent on glycolytic mechanisms for their energy requirements, this is certainly not the case for all or even the majority of them. Further, even in those cases which may exhibit definite regression under glycolytic inhibitor therapy, an insensitivity develops and reactivation of the process occurs. These findings are discussed in relation to in vitro observations of cancer metabolism.
Stereoselective Reduction of Enantiopure β-Enamino Esters by Hydride:  A Convenient Synthesis of Both Enantiopure β-Amino Esters (1996)

The reduction of enantiopure β-enamino esters 1 with sodium triacetoxyborohydride in acetic acid is described. This occurs with good diastereo- and enantioselectivity to yield β-amino esters 2 and 3 (after hydrogenolysis of the N-chiral group). A model is reported for the origin of the stereoselectivity through an enol ester−diacetoxyborohydride 6, which affords the intramolecular reduction. By choosing the appropriate chiral amine, this procedure allows a straightforward preparation of both the enantiopure β-amino esters and derivatives with known biological activity, using readily available starting materials and inexpensive reagents and conditions.
Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules (2005)

Recent studies have shown that surfactant components, in particular the collectins surfactant protein (SP)-A and -D, modulate the phagocytosis of various pathogens by alveolar macrophages. This interaction might be important not only for the elimination of pathogens but also for the elimination of inhaled allergens and might explain anti-inflammatory effects of SP-A and SP-D in allergic airway inflammation. We investigated the effect of surfactant components on the phagocytosis of allergen-containing pollen starch granules (PSG) by alveolar macrophages. PSG were isolated from Dactylis glomerata or Phleum pratense, two common grass pollen allergens, and incubated with either rat or human alveolar macrophages in the presence of recombinant human SP-A, SP-A purified from patients suffering from alveolar proteinosis, a recombinant fragment of human SP-D, dodecameric recombinant rat SP-D, or the commercially available surfactant preparations Curosurf and Alveofact. Dodecameric rat recombinant SP-D enhanced binding and phagocytosis of the PSG by alveolar macrophages, whereas the recombinant fragment of human SP-D, SP-A, or the surfactant lipid preparations had no effect. In addition, recombinant rat SP-D bound to the surface of the PSG and induced aggregation. Binding, aggregation, and enhancement of phagocytosis by recombinant rat SP-D was completely blocked by EDTA and inhibited by d-maltose and to a lesser extent by d-galactose, indicating the involvement of the carbohydrate recognition domain of SP-D in these functions. The modulation of allergen phagocytosis by SP-D might play an important role in allergen clearance from the lung and thereby modulate the allergic inflammation of asthma.
E-Cadherin Inhibits Cell Surface Localization of the Pro-Migratory 5T4 Oncofetal Antigen in Mouse Embryonic Stem Cells (2007)

Epithelial-mesenchymal transition (EMT) events occur during embryonic development and are important for the metastatic spread of epithelial tumors. We show here that spontaneous differentiation of mouse embryonic stem (ES) cells is associated with an E- to N-cadherin switch, up-regulation of E-cadherin repressor molecules (Snail and Slug proteins), gelatinase activity (matrix metalloproteinase [MMP]-2 and -9), and increased cellular motility, all characteristic EMT events. The 5T4 oncofetal antigen, previously shown to be associated with very early ES cell differentiation and altered motility, is also a part of this coordinated process. E- and N-cadherin and 5T4 proteins are independently regulated during ES cell differentiation and are not required for induction of EMT-associated transcripts and proteins, as judged from the study of the respective knockout ES cells. Further, abrogation of E-cadherin-mediated cell-cell contact in undifferentiated ES cells using neutralizing antibody results in a reversible mesenchymal phenotype and actin cytoskeleton rearrangement that is concomitant with translocation of the 5T4 antigen from the cytoplasm to the cell surface in an energy-dependent manner. E-cadherin null ES cells are constitutively cell surface 5T4 positive, and although forced expression of E-cadherin cDNA in these cells is sufficient to restore cell-cell contact, cell surface expression of 5T4 antigen is unchanged. 5T4 and N-cadherin knockout ES cells exhibit significantly decreased motility during EMT, demonstrating a functional role for these proteins in this process. We conclude that E-cadherin protein stabilizes cortical actin cytoskeletal arrangement in ES cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.
Highly porous and stable metal–organic frameworks for uranium extraction (2013)

Three metal–organic frameworks (MOFs) of the UiO-68 network topology were prepared using the amino-TPDC or TPDC bridging ligands containing orthogonal phosphorylurea groups (TPDC is p,p′-terphenyldicarboxylic acid), and investigated for sorption of uranium from water and artificial seawater. The stable and porous phosphorylurea-derived MOFs were shown to be highly efficient in sorbing uranyl ions, with saturation sorption capacities as high as 217 mg U g−1 which is equivalent to binding one uranyl ion for every two sorbent groups. Coordination modes between uranyl groups and simplified phosphorylurea motifs were investigated by DFT calculations, revealing a thermodynamically favorable monodentate binding of two phosphorylurea ligands to one uranyl ion. Convergent orientation of phosphorylurea groups at appropriate distances inside the MOF cavities is believed to facilitate their cooperative binding with uranyl ions. This work represents the first application of MOFs as novel sorbents to extract actinide elements from aqueous media.
Fluorescence of 2, 4, 6, 8-Substituted Pyrimido-[5, 4d]-pyrimidines (1967)

2,4,6,8-テトラクロルピリミド[5,4d]-ピリミジン(I)から2,4,6,8-テトラアニリノピリミド[5,4d]-ピリミジン同族体(II)と2,6-ジアルコキシ-4,8-ジアニリノピリミド[5,4d]-ピリミジン同族体(III)を合成し,そのケイ光をしらべた。IIは微かに緑色を帯びた鮮明な黄色結晶で緑黄色ないし青緑色の強いケイ光を有した。IIのジオキサン溶液に365mμの波長を中心とした紫外線を照射すると, 極大波長が475mμ前後のケイ光を発した。IIIは白色ないし淡黄色結晶で紫青色ないし青緑色の強いケイ光を有した。IIIの石油エーテル溶液に前記の紫外線を照射すると, 極大波長が420mμ前後のケイ光を発した。IIIはナイロンに染着し視覚的にも増白効果を示すが,耐光堅ロウ性は良くなかった。