gebhart/patrepeval huggingface dataset:
Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis (1999)

The co-ordinate role of the Th1 cytokine IL-12 and the proinflammatory cytokine TNF in arthritis was explored using the DBA/1 mouse model, collagen-induced arthritis (CIA). In this study, mice with established arthritis were treated with anti-IL-12 and/or anti-TNF antibodies for 10 days from the onset of disease. Clinical assessment showed that the combined antibody treatment ameliorated disease severity to a greater extent than anti-TNF alone. Supporting these observations, histological analysis revealed that there was a reduced joint damage in the mice that received combined anti-IL-12 and anti-TNF treatment, compared to the other treatment groups. Anti-IL-12 had no statistically significant effect on the clinical outcome of disease. The combination of anti-IL-12 and anti-TNF treatment was found to reduce collagen type II (CII)-specific lymph node cell IFN-gamma production and proliferation, as well as decrease the anti-CII IgG2a:IgG1 ratio more effectively than either treatment alone. When the antibodies were added to synovial cells from arthritic mice and bone marrow macrophages in vitro, anti-TNF diminished IL-12 production, but anti-IL-12 had no effect on TNF production. These data suggest that, through the partial regulation of IL-12, TNF modulates the immune response in arthritis, as well as the inflammatory response. The synergistic action of anti-TNF and anti-IL-12 on CIA may provide a new therapeutic approach for treating rheumatoid arthritis.
Biomaterials with permanent hydrophilic surfaces and low protein adsorption properties (1995)

Low protein adsorbing polymer films have been prepared with which to fabricate intravenous containers, designed for compatibility with low concentrations of protein drugs. The material is economically manufactured utilizing physical melt blending of water-soluble surface-modifying polymers (PEO, PEOX, PVA, and PNVP) with a base polymer (EVA, PP, PETG, PMMA, SB, and nylon). Permanency of the hydrophilic surfaces so generated was confirmed by surface contact angle experiments and total organic carbon leachables analysis of the aqueous contacting solutions. Binding of IgG, albumin and insulin was studied. A sixfold reduction of protein adsorption was obtained by adding 5% PVA13K to EVA, for IgG at a bulk concentration of 2.5 ppm. Surface bound protein measured by micro-BCA colorimetry, agreed with the solution protein lost, as determined by the Fluoraldehyde procedure. Imaging of the protein exposed plastic surfaces by silver enhanced protein conjugated gold staining agreed with the quantitative assay determinations.
Glycerol‐insensitive Arabidopsis mutants: gli1 seedlings lack glycerol kinase, accumulate glycerol and are more resistant to abiotic stress (2004)

The aim of this study was to investigate the process of glycerol catabolism in germinating Arabidopsis seed. A genetic screen was performed to isolate glycerol-insensitive (gli) mutant seedlings. Three separate mutant loci were identified (gli1, gli2 and gli3). Of these, only gli1 is unable to utilise glycerol. Following germination, gli1 seedlings transiently accumulate glycerol derived from the breakdown of storage oil and are more resistant to hyperosmotic stress, salt stress, oxidative stress, freezing and desiccation. Enzyme assays revealed that gli1 lacks glycerol kinase activity. GLI1 mapped to chromosome 1 near the putative glycerol kinase gene NHO1. Mutations in this gene were identified in three independent gli1 alleles. A cDNA encoding GLI1 was cloned and its function was proven by complementation of an Escherichia coli glycerol kinase (glpK) deletion strain. Quantitative RT-PCR analysis showed that GLI1 is expressed in all tissues, but is transiently upregulated during early post-germinative growth and leaf senescence. These data show that glycerol kinase is required for glycerol catabolism in Arabidopsis and that the accumulation of glycerol can enhance resistance to a variety of abiotic stresses associated with dehydration.
Neuromodulation of bladder activity by stimulation of feline pudendal nerve using a transdermal amplitude modulated signal (TAMS) (2011)

Both inhibitory and excitatory effects on bladder activity can be obtained in cats using the non-invasive neural stimulation approach. This pre-clinical study warrants a further clinical trial to investigate the possibility of using this non-invasive stimulation method to treat incontinence or urinary retention.
DNA synthesis, blood flow, and glucose utilization in experimental rat brain tumors (1989)

The relationships between distribution of deoxyribonucleic acid (DNA)-synthesizing cells (S-phase cells) and blood flow and glucose utilization were investigated in rat brain tumors using an autoradiographic technique and immunoperoxidase staining for bromodeoxyuridine (BUdR). Two strains of rat brain tumor were used: strain A and B, both induced by the Rous sarcoma virus. Strain A was biologically more malignant than strain B. The blood flow was unevenly distributed in the tumor, compared with the contralateral cortex, the average blood flow in the tumor was about 50% in strain A and 60% in strain B. The distribution of blood flow did not correlate with the distribution of S-phase cells or with the distribution of vessels in the tumor in either strain A or B. The average glucose utilization in strain A was about 250% and in strain B about 170% of that of the contralateral cortex. The high glucose utilization area correlated well with the distribution of BUdR-positive nuclei in strain B. These findings suggest that the biological malignancy of a tumor correlates with glucose utilization rather than with blood flow, and that malignant brain tumors show a marked increase in glucose utilization for nucleic acid synthesis.
Textile Strain Sensors Characterization- Sensitivity, Linearity, Stability and Hysteresis (2010)

ABSTRACT In this paper 4 different textile based strain sensors for measuring different level of strains were presented. Sensor consist a conductive part formed by coating or weaving technique. Both elastic and inelastic textile substrates were selected to achieve the required stains in applications. Sensor configuration was characterized using a tensile tester and measuring the resistance parallel by microprocessor. A linear working range with transfer function of each sensor was found. Coated sensor gives a good stability, while woven sensor was relative less stable. Inelastic textile substrate reduces the hysteresis error caused by refraction and construction of materials. The sensitivities were between 2.5 to 9 vary with different sensors. This paper finished by a discussion of how to choose sensors with different applications, among which sensor function and processability are most important aspects to be considering.
The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults (2010)

Vaccination with AERAS-402 is safe and immunogenic in healthy adults. The immunity induced by the vaccine appears promising: polyfunctional T cells are thought to be important for protection against intracellular pathogens such as Mycobacterium tuberculosis, and evidence is accumulating that CD8(+) T cells are also important. AERAS-402 induced a robust and durable CD8(+) T-cell response, which appears extremely promising. Clinical trial registered with www.sanctr.gov.za (NHREC no. 1381).
Design and Evaluation of an "Around the SmartPhone" Technique for 3D Manipulations on Distant Display (2015)

In this paper, we present the "Around the SmartPhone" interaction technique for manipulating 3D elements displayed on a distant screen. The design of the technique is based on the selection of the most appropriate value for characteristics useful to discriminate existing tactile and tangible techniques for 3D manipulations. We perform two user studies to compare this around-device technique for translating and rotating 3D objects, with two existing tangible and tactile solutions, in terms of performance and user's preference. The literature establishes that the tactile technique evaluated is the best tactile technique among the existing tactile techniques for 3D manipulation. Despite this result, our user study reveals that the two others perform significantly better. In addition, when feedback visibility is preserved, the around-device technique offers similar performance results than the tangible one. Finally, the around-device technique is significantly preferred over the two others in every condition.
Extension of the Therapeutic Window for Recombinant Tissue Plasminogen Activator With Argatroban in a Rat Model of Embolic Stroke (2001)

This study demonstrates that the combination of argatroban and rtPA extends the window of opportunity for treatment of stroke to 4 hours without increasing hemorrhagic transformation.
Sequential resonant tunneling through a multiquantum well superlattice (1986)

We report the observation of two negative conductance regions in the low-temperature photocurrent-voltage characteristic of tight-binding multiquantum well (35 periods) 1-μm-thick Al0.48 In0.52As/ Ga0.47 In0.53As superlattices grown by molecular beam epitaxy. The two peaks occur at voltages corresponding to a potential energy drop across the superlattice period equal to the energy differences between the first two excited states and the ground state of the quantum wells. This provides direct evidence of sequential resonant tunneling between the ground and excited states of adjacent wells alternated with intrawell energy relaxation.
A Fourteenth-century 'Bestiaire d'amour' (1991)

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The distribution of cartilage thickness within the joints of the lower limb of elderly individuals (1998)

The objective of this study was to investigate the normal distribution of cartilage thickness in the major joints of the lower limb in elderly individuals. A 12.5 MHz ultrasound transducer was used to measure the cartilage thickness in the right and left hip, knee and ankle joint of 10 individuals aged between 62 and 99 y. Distribution patterns of cartilage thickness were derived by b-spline interpolation and the average distribution computed in each surface. The maximum cartilage thickness in the hip joint was 2.6 (+/-0.36) mm and the mean thickness 1.3 (+/-0.17) mm. The CV% (a measure of thickness inhomogeneity within the joint surface) was 32%. In the knee, the maximal and mean values were 3.8 (+/-0.46) mm and 1.9 mm (+/-0.24) mm, respectively (CV% = 34%), and in the ankle 1.7 (+/-0.25) mm and 1.0 (+/-0.16) mm (CV% = 32%). Systematic differences existed between both sides in the knee, the distal femur showing a significantly greater thickness on the right. While the mean and maximal thicknesses were systematically higher in the knee than in the hip, and in the hip higher than in the ankle (P < 0.05), there were no systematic differences in the thickness inhomogeneity of the 3 joints. Only the malleolus showed a somewhat more uniform thickness than the other joint surfaces. The variability between individuals was similar for all joints for mean thickness, but the interindividual variability of the maximal thickness values was highest in the knee and lowest in the ankle. Whereas the cartilage thickness distributions in the joints of the lower limb have been suggested to reflect the pressure distribution within the articular surface, the absolute thickness is proposed to be a function of dynamic loading (range of motion) during gait, rather than being a reflection of the static articular pressure.
Image manipulation detection (2006)

Techniques and methodologies for validating the authenticity of digital images and testing for the presence of doctoring and manipulation operations on them has recently attracted attention. We review three categories of forensic features and discuss the design of classifiers between doctored and original images. The performance of classifiers with respect to selected controlled manipulations as well as to uncontrolled manipulations is analyzed. The tools for image manipulation detection are treated under feature fusion and decision fusion scenarios.
DiarrheagenicEscherichia coli (1998)

Escherichia coli is the predominant nonpathogenic facultative flora of the human intestine. Some E. coli strains, however, have developed the ability to cause disease of the gastrointestinal, urinary, or central nervous system in even the most robust human hosts. Diarrheagenic strains of E. coli can be divided into at least six different categories with corresponding distinct pathogenic schemes. Taken together, these organisms probably represent the most common cause of pediatric diarrhea worldwide. Several distinct clinical syndromes accompany infection with diarrheagenic E. coli categories, including traveler's diarrhea (enterotoxigenic E. coli), hemorrhagic colitis and hemolytic-uremic syndrome (enterohemorrhagic E. coli), persistent diarrhea (enteroaggregative E. coli), and watery diarrhea of infants (entero-pathogenic E. coli). This review discusses the current level of understanding of the pathogenesis of the diarrheagenic E. coli strains and describes how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens.
Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease (2004)

Crohn's disease patients with FCGR3A-158 V/V genotype have a better biological and, possibly, clinical response to infliximab.
Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames (1999)

The HPr-1 cells expressed prostatic acid phosphatase and cytokeratins K8 and K18, proving that they were prostate epithelial cells. They were benign in nude mice tumor formation and soft agar colony formation assay. The HPr-1 cell line is an in vitro representation of early prostate neoplastic progression.
Intestinal permeability is increased in bronchial asthma (2004)

Intestinal permeability is increased in children with asthma, suggesting that the whole mucosal system may be affected.
Insights into alternative prion protein topologies induced under high hydrostatic pressure (2004)

The critical step in the pathogenesis of transmissible spongiform encephalopathies (TSEs) appears to be a conformational transition of a normal prion protein (PrPC) into a misfolded isoform (PrPSc). To gain insight into the structural conversion of the prion protein we have exploited the use of high hydrostatic pressure combined with various spectroscopic techniques. In vitro transitions of the recombinant PrP to a scrapie-like form have never resulted in an infectious structure. It is our hypothesis that the acquisition of the disease-causing conformation depends on folding pathways which are difficult to attain. We attempt to favour, via specific reaction conditions at high pressure, alternative routes of misfolding leading to a stable infectious amyloidogenic conformer. Our results have demonstrated the potential of high pressure to reveal various prion structural changes, which are inaccessible by conventional methods. Especially, we have characterized a pressure-induced conformer in which the normal α-helical structure is changed into a highly aggregated β-sheet conformation showing markedly increased resistance to proteolysis (key markers of potential infectious agents). Our work may have important implications, not only for ultimately proving the protein-only hypothesis and for understanding the basic mechanism of the disease, but also for developing preventative and therapeutic measures.
Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway (2018)

MSC exosome enhanced Treg production in vitro and in vivo through an APC-mediated pathway.
Gene Transfer to the Intestinal Tract: A New Approach Using Selective Injection of the Superior Mesenteric Artery (1997)

Gene transfer to the intestinal tract has many potential applications, including complementation of single gene disorders, genetic immunization, and ectopic production of therapeutic molecules. Because the intralumenal approach to vector administration has not been highly successful, we tested whether the circulation can be used as a route to transfer genes to intestinal cells. The superior mesenteric artery (SMA) and vein (SMV) of adult Lewis rats were isolated and an adenoviral vector expressing the Escherichia coli LacZ gene was injected into the SMA. In one set of experiments, both vessels remained patent throughout the entire procedure. In a second group of animals, both vessels were occluded by clamping the SMA 1 cm distal to the injection site and the SMV proximal to the portal vein. In the absence of vascular clamps, gene transfer was evident throughout the small bowel, localized near the serosal surface within the muscularis propria. Occlusion of the SMA and SMV limited gene delivery to a short segment of bowel and shifted beta-galactosidase activity toward the mucosal surface. At the level of microscopy, most of the transduction events were in the lamina propria; transduced mucosal epithelial cells were occasionally observed. These data demonstrate that intestinal gene transfer can be accomplished through the circulation, and that targeting specific regions is feasible.
236. Experiments on the preparation of indolocarbazoles. Part VIII. The preparation of 1-methylindolo(2′ : 3′-2 : 3)carbazole (1956)

M. L. Swindells and M. L. Tomlinson, J. Chem. Soc., 1956, 1135 DOI: 10.1039/JR9560001135
Diabetes and Decline in Heart Disease Mortality in US Adults (1999)

The decline in heart disease mortality in the general US population has been attributed to reduction in cardiovascular risk factors and improvement in treatment of heart disease. The smaller declines in mortality for diabetic subjects in the present study indicate that these changes may have been less effective for people with diabetes, particularly women.
Development of an interleukin-2 slow delivery system. (1989)

The authors developed a slow delivery system for interleukin-2 (IL-2) using highly purified bovine collagen to overcome the rapid clearance and side effects of IL-2; 1 X 10(6) microns of recombinant human IL-2 was successfully infused into needle-shaped "IL-2 mini-pellets". Pharmacokinetic study in C57BL/6 mice revealed that a single subcutaneous injection of an IL-2 mini-pellet could prolong IL-2 retention and decrease maximal concentration in the serum. Elimination half-life was 360 min for subcutaneously injected IL-2 mini-pellets, while it was 8 and 15 min, respectively, for intravenous and subcutaneous injections of aqueous IL-2. No side effects were observed throughout the experiment. This slow delivery system using collagen as a carrier proved to be effective and may be applicable to other kinds of drugs.
Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation (2005)

Exposure to dextran sulfate sodium (DSS) induces acute colitis, which is normally resolved after DSS removal. To study chronicity, mice are typically subjected to three to five cycles of weekly DSS exposures, each followed by a 1- to 2-wk rest period. Here, we describe a novel and convenient way of inducing chronic, progressive colitis by a single exposure to DSS. C57BL/6 mice exposed to DSS for 5 days developed acute colitis that progressed to severe chronic inflammation. The plasma haptoglobin levels remained high during the chronic phase, showing that the inflammation was active. Surprisingly, the mice regained their original weight along with the progression of colitis, and the only apparent symptom was loose feces. Histopathological changes 4 wk after DSS removal were dense infiltrates of mononuclear cells, irregular epithelial structure, and persistent deposits of collagen. A progressive production of the cytokines IL-1beta, IL-12 p70, and IL-17 correlated with the extensive cellular infiltration, whereas high IFN-gamma production was mainly found late in the chronic phase. Similar to C57BL/6 mice, BALB/c mice exposed to 5 days of DSS developed acute colitis as previously described. The acute colitis was accompanied by elevated plasma levels of haptoglobin and increased colonic levels of IL-1alpha/beta, IL-6, IL-18, and granulocyte colony-stimulating factor. However, soon after DSS removal, BALB/c mice recovered and were symptom free within 2 wk and completely recovered 4 wk after DSS removal in terms of histopathology, haptoglobin levels, and local cytokine production. In summary, these data stress the effect of genetic background on the outcome of DSS provocation. We believe that the present protocol to induce chronic colitis in C57BL/6 mice offers a robust model for validating future therapies for treatment of inflammatory bowel disease.
Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma (2000)

Hereditary paraganglioma (PGL) is characterized by the development of benign, vascularized tumors in the head and neck. The most common tumor site is the carotid body (CB), a chemoreceptive organ that senses oxygen levels in the blood. Analysis of families carrying the PGL1 gene, described here, revealed germ line mutations in the SDHD gene on chromosome 11q23. SDHD encodes a mitochondrial respiratory chain protein-the small subunit of cytochrome b in succinate-ubiquinone oxidoreductase (cybS). In contrast to expectations based on the inheritance pattern of PGL, the SDHD gene showed no evidence of imprinting. These findings indicate that mitochondria play an important role in the pathogenesis of certain tumors and that cybS plays a role in normal CB physiology.
Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. (1997)

We suggest that IL-4, IL-10, and IL-13 may be some of the cytokines that contribute to the disease process, and that IL-13 may be a serologic indicator of systemic inflammation in patients with SSc.
Molecular physiology of reverse cholesterol transport. (1995)

Reverse cholesterol transport (RCT) is the pathway by which peripheral cell cholesterol can be returned to the liver for catabolism. Evidence of specific functions for molecular structures within individual plasma lipoprotein species has rapidly accumulated from recent studies using molecular and cellular physiology techniques. The removal of cholesterol from cells, like its delivery, appears to be specific and well regulated. Although further research will be needed, RCT can now be understood in molecular terms.