gebhart/patrepeval huggingface dataset:
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma (2001)

The t(4;14) translocation occurs frequently in multiple myeloma (MM) and results in the simultaneous dysregulated expression of 2 potential oncogenes, FGFR3 (fibroblast growth factor receptor 3) from der(14) and multiple myeloma SET domain protein/Wolf-Hirschhorn syndrome candidate gene 1 from der(4). It is now shown that myeloma cells carrying a t(4;14) translocation express a functional FGFR3 that in some cases is constitutively activated by the same mutations that cause thanatophoric dysplasia. As with activating mutations of K-ras and N-ras, which are reported in approximately 40% of patients with MM, activating mutations of FGFR3 occur during tumor progression. However, the constitutive activation of ras and FGFR3 does not occur in the same myeloma cells. Thus the activated forms of these proteins appear to share an overlapping role in tumor progression, suggesting that they also share the signaling cascade. Consistent with this prediction, it is shown that activated FGFR3-when expressed at levels similar to those seen in t(4;14) myeloma-is an oncogene that acts through the MAP kinase pathway to transform NIH 3T3 cells, which can then generate tumors in nude mice. Thus, FGFR3, when overexpressed in MM, may be not only oncogenic when stimulated by FGF ligands in the bone marrow microenvironment, but is also a target for activating mutations that enable FGFR3 to play a ras-like role in tumor progression.
Serum 25-hydroxyvitamin D levels in early and advanced breast cancer: Table 1 (2006)

Serum levels of 25(OH)D are significantly higher in patients with early-stage breast cancer than in those with locally advanced or metastatic disease.
Behavior-based Confinement of Untrusted Applications (1999)

In my thesis, I propose a class-specific sandboxing mechanism to confine untrusted applications. The key idea is to identify different application classes like editor, browser, mail client, shell, filter, server etc and to confine applications belonging to each class in a sandbox that is tailored to the expected behavior/requirements of the class. For example, the sandbox for a MIME-mail client could be restricted to allow it to spawn only a set of helper applications explicitly listed in the mailcap file; the sandbox for an editor could be restricted to disallow network accesses and process creation. Such a mechanism retains the ease-of-use of sandboxes while significantly increasing their flexibility. End-users do not need to maintain complex access control lists or interact frequently with the security subsystem; nor do they need to depend solely on a digital signature. They can configure their systems by specifying the set of classes they would like to allow. To evaluate the feasi...
Different neuron populations in the feline lateral cervical nucleus: A light and electron microscopic study with the retrograde axonal transport technique (1986)

A comparative light and electron microscopic study was made of the two major neuron populations in the feline lateral cervical nucleus (LCN) that have an ascending projection--namely, the cervicothalamic and cervicomesencephalic neurons. The small population of neurons in the LCN that remained unlabelled after extensive injections into all known areas of LCN termination was also investigated. The intra-axonal retrograde tracing technique was employed and three different tracers were used: native horseradish peroxidase, horseradish peroxidase conjugated to wheat germ agglutinin, and cholera toxin subunit B (CTb). The diaminobenzidine and tetramethylbenzidine methods were used for the peroxidase reaction, and an immunocytochemical staining method with monoclonal antibodies was employed to localize CTb. The light microscopic cell count was performed on plastic-embedded semithin (2 micron) sections, and a section-embedding technique was used for sampling regions of interest for electron microscopy. The total number of neurons in the LCN was calculated to be 8,300, which is higher than numbers reported from other studies on frozen sections. It was concluded from control experiments that many neurons fail to counterstain in frozen sections. The average proportion of labelled cervicothalamic neurons was 94%, which accords with earlier reports. The frequency of labelled neurons projecting to the midbrain was 25-49%, depending on the method used. The highest number of labelled neurons was found with the immunocytochemical method with use of CTb as a tracer. In the electron microscopic study, the cell area, form factor, nuclear area, bouton covering ratio, mean appositional length of boutons, and bouton density were measured. There were no significant differences in these respects between the cervicothalamic and cervicomesencephalic neurons, but the unlabelled neurons differed significantly from the labelled ones, with a smaller somal area, a lower bouton covering ratio, and a larger relative nuclear area. The ascending neurons were scattered over the entire LCN, but the neurons that remained unlabelled after the extensive injections was found in its ventromedial part. It is suggested that these are interneurons. In the light microscopic study of the animals injected with CTb, the ventromedial part of the LCN displayed labelled structures resembling terminals. Electron microscopic examination of the sections revealed boutons synapsing on unlabelled neurons and dendrites. Occasionally labelled neurons and dendrites were also contacted.(ABSTRACT TRUNCATED AT 400 WORDS)
Registering stereovision surface with preoperative magnetic resonance images for brain shift compensation (2012)

Intraoperative brain deformation can significantly degrade the accuracy of image guidance using preoperative MR images (pMR). To compensate for brain deformation, biomechanical models have been used to assimilate intraoperative displacement data, compute whole-brain deformation field, and to produce updated MR images (uMR). Stereovision (SV) is an important technique to capture both geometry and texture information of exposed cortical surface at the craniotomy, from which surface displacement data (known as sparse data) can be extracted by registering with pMR to drive the computational model. Approaches that solely utilize geometrical information (e.g., closest point distance (CPD) and iterative closest point (ICP) method) do not seem to capture surface deformation accurately especially when significant lateral shift occurs. In this study, we have developed a texture intensity-based method to register cortical surface reconstructed from stereovision after dural opening with pMR to extract 3D sparse data. First, a texture map is created from pMR using surface geometry before dural opening. Second, a mutual information (MI)-based registration was performed between the texture map and the corresponding stereo image after dural opening to capture the global lateral shift. A block-matching algorithm was then executed to differentiate local displacements in smaller patches. The global and local displacements were finally combined and transformed in 3D following stereopsis. We demonstrate the application of the proposed method with a clinical patient case, and show that the accuracy of the technique is 1-2 mm in terms of model-data misfit with a computation time &lt;10 min.
The time of appearance and disappearance of fetal DNA from the maternal circulation (1995)

A single copy Y-chromosome DNA sequence was amplified using the polymerase chain reaction (PCR) from the peripheral blood of 30 women who had achieved a pregnancy through an in vitro fertilization (IVF) programme. The time of conception was known precisely and was confirmed by serial ultrasound scans. Conceptions were dated as the number of weeks after fertilization plus 2, to give a time equivalent to the obstetric menstrual dating of the pregnancy (LMP). Y-chromosome-specific DNA was detected in all pregnancies with a male fetus (18/30). The earliest detection was at 4 weeks and 5 days, and the latest at 7 weeks and 1 day. Y-chromosome-specific sequences were no longer detected in any of the male pregnancies 8 weeks after delivery. No Y-chromosome sequences were detected in any of the pregnancies where only female babies were delivered. This demonstrates that fetal DNA appears in the maternal circulation early in the first trimester, that it can be identified in all pregnancies tested by 7 weeks, that it continues to be present throughout pregnancy, and that it has been cleared from the maternal circulation 2 months after parturition. Early non-invasive prenatal diagnosis for aneuploidies and inherited disorders will be possible in all pregnancies if fetal cells can be isolated free from maternal contamination (or identified accurately in the presence of maternal cells) without problems of contamination from previous pregnancies.
Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. (1967)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Isolation and chromosomal localization of a novel nonerythroid ankyrin gene (1991)

Immunoreactive isoforms of erythrocyte ankyrin have been shown to be present in a variety of nonerythroid tissues. Isolation of the genes that encode these isoforms will clarify their relationship to erythrocyte ankyrin. Using an erythrocyte ankyrin cDNA clone as a hybridization probe, we screened a human genomic library and isolated a clone that hybridizes with the probe at low stringency but not at high stringency. Partial nucleotide sequence of the clone revealed the presence of a 99-bp segment that is homologous to an exon of the erythrocyte ankyrin gene. Northern analysis showed that a labeled fragment of the clone hybridized to a 7-kb message in RNA of fetal brain but not of erythroid cells, suggesting that this clone is part of a novel gene that is expressed predominantly in nonerythroid tissue. Comparison of the sequence of the genomic clone with that of a recently isolated cDNA clone for brain ankyrin (Otto et al., 1989) showed identity of 96 of 99 bp between the putative exon and a segment of the cDNA clone (V. Bennett, personal communication, 1991), suggesting that the genomic clone is part of a gene for nonerythroid ankyrin, which we have designated ANK2. By analysis of somatic cell hybrids and fluorescence in situ hybridization, we assigned ANK2 to human chromosome 4 at a position equivalent to bands 4q25-q27.
ORIGINAL ARTICLE: Solubilization of vorinostat by cyclodextrins (2009)

CDs, particularly RM-β-CD and HP-β-CD, increased vorinostat's solubility. Future studies could be focused on the application of HP-β-CD in parenteral delivery of vorinostat or using RM-β-CD as an oral absorption enhancer. Molecular simulation appeared to be a useful tool for the selection of appropriate CD as excipient for drug delivery.
General relations between IP2, IP3, and offsets in differential circuits and the effects of feedback (2003)

In the presence of offsets, all balanced circuits show an apparent second-order distortion. Differential feedback lowers third-order nonlinearity and also these second-order effects. The results are important for the baseband circuits of zero-IF wireless receivers, which often need a very large second-order intercept point. It is shown that a published analysis of distortion in a bipolar double-balanced mixer is a special case of these general relationships.
PSEUDOMONAS AERUGINOSA LASA SPECIFICITY, USING TROPOELASTIN PENTAPEPTIDES AS SUBSTRATES (2000)

Conference Abstract| October 01 2000 PSEUDOMONAS AERUGINOSA LASA SPECIFICITY, USING TROPOELASTIN PENTAPEPTIDES AS SUBSTRATES Sandrine Vessillier; Sandrine Vessillier 1Laboratoire Biochimie Analytique et Synthèse Bioorganique - EA 1659 Université Lyon 1, F-69622 VILLEURBANNE Cedex Search for other works by this author on: This Site PubMed Google Scholar Jacques Bernillon; Jacques Bernillon 1Laboratoire Biochimie Analytique et Synthèse Bioorganique - EA 1659 Université Lyon 1, F-69622 VILLEURBANNE Cedex Search for other works by this author on: This Site PubMed Google Scholar Joëlle Saulnier; Joëlle Saulnier 1Laboratoire Biochimie Analytique et Synthèse Bioorganique - EA 1659 Université Lyon 1, F-69622 VILLEURBANNE Cedex Search for other works by this author on: This Site PubMed Google Scholar Jean Wallach Jean Wallach 1Laboratoire Biochimie Analytique et Synthèse Bioorganique - EA 1659 Université Lyon 1, F-69622 VILLEURBANNE Cedex Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 2000 Biochemical Society2000 Biochem Soc Trans (2000) 28 (5): A323. https://doi.org/10.1042/bst028a323b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Sandrine Vessillier, Jacques Bernillon, Joëlle Saulnier, Jean Wallach; PSEUDOMONAS AERUGINOSA LASA SPECIFICITY, USING TROPOELASTIN PENTAPEPTIDES AS SUBSTRATES. Biochem Soc Trans 1 October 2000; 28 (5): A323. doi: https://doi.org/10.1042/bst028a323b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
New technologies for advanced LCD‐TV performance (2004)

Abstract— Samsung intends to be the world leader in LCD‐TV through a combination of superior product technology, advanced process execution, and aggressive capitalization. This paper explores and updates Samsung's latest developments toward its goal of ultimate LCD‐TV performance and market leadership. Samsung's development of Super PVA (S‐PVA) represents a key performance achievement. S‐PVA is a new technology which enables screen quality advantages over S‐IPS and MVA, including high transmittance, &gt;1000:1 contrast ratio, and wide angle of view with no off‐axis image inversion. This new technology is described in detail. This paper also addresses the other remaining performance issues facing LCD‐TV, including Samsung's plans for addressing these challenges. Until recently, inter‐gray response time and associated motion blur were significant issues for achieving quality LCD‐TV images. Samsung has invented DCC‐II technology to achieve sub‐10‐msec response time, and this achievement is described. Other technology advancements, including next‐generation color performance and ultra‐low black performance, are discussed. Samsung has announced the development of a 57‐in. full‐HD (1920 × 1080) LCD‐TV panel, the world's largest, based on S‐PVA technology. This product represents the culmination of many technical breakthroughs, and is discussed herein. Samsung's LCD manufacturing strategy, which includes the world's first generation 7 LCD fab, is also described.
Quartz Crystal Resonators as Sensors in Liquids Using the Acoustoelectric Effect (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuartz Crystal Resonators as Sensors in Liquids Using the Acoustoelectric EffectZack A. Shana and Fabien. JosseCite this: Anal. Chem. 1994, 66, 13, 1955–1964Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ac00085a006https://doi.org/10.1021/ac00085a006research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DYE EXTRUSION TECHNIQUE (DE-TECH) (2009)

Results suggest that Dye Extrusion Technique may be an effective technique for the identification of occult retinal breaks and may facilitate simple techniques of detachment repair. No evidence of retino-toxicity from the use of trypan blue was found but the study had limited power to detect adverse effects.
Inhibitory and Noninhibitory Monoclonal Antibodies to Human Cytochrome P450 2E1 (1996)

A panel of 17 hybridomas producing (MAbs) against human cytochrome P450 2E1 (h2E1) was generated by immunizing mice with baculovirus-expressed h2E1. All 17 hybridoma clones gave positive ELISA or immunoblots with either baculovirus-or vaccinia virus-expressed h2E1. Two of the latter were further developed due to their desirable characteristics. MAb 1-73-18 was found to be a powerful inhibitor of P450 h2E1; however, it did not yield a positive immunoblot. MAb 2-106-12 was found to be noninhibitory but formed a strong positive immunoblot with P450 h2E1. These MAbs to h2E1 were highly specific and did not recognize six other human P450s as tested with ELISA or immunoblot analyses. The MAbs to baculovirus-expressed h2E1 also reacted with h2E1 expressed from a vaccinia virus vector system as well as with microsomal fractions of human and acetone-treated rat liver. MAb 1-73-18 inhibited h2E1 enzyme activity catalyzing the metabolism of phenanthrene by 85%, p-nitroanisole by 90%, 4-methylanisole by 60-80%, toluene by 90%, and chlorzoxazone by 90%. The inhibitory MAb 1-73-18 is uniquely useful for determining the contribution of h2E1 to the metabolism of h2E1 substrates in human liver containing multiple P450s. The quantitatively determined contribution of h2E1 to the metabolism of the above substrates ranged from 25% to 75%. Thus, h2E1 was responsible for the following percentages of the total metabolism in human liver: p-nitroanisole (35%), phenanthrene (23%), methylanisole to cresol (25%), methylanisole to methoxybenzyl alcohol (12%), toluene (40%), and chlorzoxazone (72%). The MAb 2-106-12 forming a strong immunoblot is useful for determining the amount of h2E1 protein in a tissue. Thus the utility of the inhibitory and immunoblot positive MAbs is complementary and can determine both the contribution of h2E1 to the metabolism of specific substrates and the amount of h2E1 protein in human tissue. The analyses of metabolism with the inhibitory MAb 1-73-18 can be generalized and applicable to all h2E1 substrates.
Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor (1992)

The DNA-binding proteins which recognize the regulatory sequence elements of the hepatitis B virus (HBV) major surface antigen promoter were examined by gel retardation analysis, using nuclear extracts from the human hepatoma cell line Huh7. Using this assay, we identified four regions (B, D, E, and F) of the promoter that interact with the same or similar transcription factor(s). In addition, the recognition sequence for the Sp1 transcription factor bound the same or similar transcription factor(s) present in Huh7 cell nuclear extracts, and this binding was inhibited by the four major surface antigen promoter elements, B, D, E, and F. Purified Sp1 transcription factor was shown to bind to three (B, D, and F) of the major surface antigen promoter regulatory sequence elements by DNase I footprinting. Using transient transfection assays with Drosophila Schneider line 2 cells, we found that transcription from the major surface antigen promoter was transactivated by exogenously expressed Sp1, whereas transcription from the other three HBV promoters was not. Deletion analysis of the major surface antigen promoter demonstrated that the promoter region between -35 and +157 was sufficient to confer Sp1 responsiveness. This promoter region includes one of the regulatory elements footprinted by the purified Sp1 transcription factor. The function of the B, D, E, and F promoter elements was further examined by using these binding sites cloned into a minimal promoter element. Each of these regulatory regions transactivated transcription from the minimal promoter element in response to exogenously expressed Sp1. This finding demonstrates that the HBV major surface antigen promoter contains four functional Sp1 binding sites which probably contribute to the level of expression from this promoter during viral infection.
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase 1/11 trial comparing two schedules (1994)

Paclitaxel can be safely administered in a 1-hour infusion in an outpatient setting, either as a single dose or in divided doses for three days. Severe hypersensitivity reactions did not occur in 162 treatment courses, and neutropenia was mild in most patients. Incorporation of this dose and these schedules of paclitaxel into combination chemotherapy regimens should be feasible. An investigation of higher paclitaxel doses given in a 1-hour infusion is currently in progress.
Understanding Hand-Object Manipulation with Grasp Types and Object Attributes (2016)

Our goal is to automate the understanding of natural hand-object manipulation by developing computer visionbased techniques. Our hypothesis is that it is necessary to model the grasp types of hands and the attributes of manipulated objects in order to accurately recognize manipulation actions. Specifically, we focus on recognizing hand grasp types, object attributes and actions from a single image within an unified model. First, we explore the contextual relationship between grasp types and object attributes, and show how that context can be used to boost the recognition of both grasp types and object attributes. Second, we propose to model actions with grasp types and object attributes based on the hypothesis that grasp types and object attributes contain complementary information for characterizing different actions. Our proposed action model outperforms traditional appearance-based models which are not designed to take into account semantic constraints such as grasp types or object attributes. Experiment results on public egocentric activities datasets strongly support our hypothesis.
Improvement of the GenTHREADER method for genomic fold recognition (2003)

http://www.psipred.net.