gebhart/patrepeval huggingface dataset:
Adhesion receptor profile of thymic B-cell lymphoma. (1992)

Primary thymic B-cell lymphoma is clinically characterized by aleukemic, highly aggressive local growth, infrequent distant metastasis, and infrequent secondary lymph node involvement. VLA-1 to VLA-6 are cell surface molecules binding to matrix molecules such as collagen, fibronectin, epiligrin, and laminin. VLA-4 additionally binds to VCAM-1 and ICAM-2, thus mediating intercellular adhesion. Other molecules involved in cell/cell adhesion are LFA-1 (CD11a/CD18), Mac-1(CD11b/CD18) and their ligand ICAM-1 (CD54), p150,95 (CD11c/CD18), LFA-3 (CD58), CD44, and LECAM-1. Twenty-three tumors, together with normal lymphoid tissue, were immunohistochemically examined to investigate the expression pattern of these molecules in thymic B-cell lymphomas and in their putative normal counterparts, namely thymic medullary B cells. Thymic B-cell lymphomas consistently lacked VLA-1,-2,-3,-5,-6, and CD11b, expressed ICAM-1 in 21 of 23 cases but were heterogenous for VLA-4, LFA-1, CD11c, LFA-3, CD44, and LECAM-1. Presence of LFA-1 correlated with LFA-3 expression (P = 0.029). The receptor profile of thymic B-cell lymphoma was reminiscent of the expressional status of normal thymic medullary B cells in some aspects but deviated in others: Assuming that, in terms of differentiation, thymic B-cell lymphoma is related to the asteroid variant of thymic medullary B cells, a propensity to down-regulate/lose VLA-4, CD11a, CD44, and LECAM-1 would have to be supposed in conjunction with a tendency to overexpress ICAM-1 and LFA-3. Sclerosis as an inconsistent phenomenon in thymic B-cell lymphoma was absent in 8 of 23 tumors. Presence of sclerosis correlated with LECAM-1 expression of the tumor cells (P = 0.038). Recent studies suggest that a locally growing/aleukemic phenotype of a B-cell neoplasia might be determined by the phenotype VLAs-, LFA-1+, ICAM-1+, CD44-, and LECAM-1-. Our data corroborate this view.
30 nm ultra-thin-body SOI MOSFET with selectively deposited Ge raised S/D (2002)

MOSFETs with selectively deposited Ge raised source/drain (S/D) implemented in 8 nm ultra-thin-body (UTB) SOI are demonstrated. The Ge is selectively deposited by LPCVD and annealed at a low temperature using RTA (650/spl deg/C, 20 s). Devices with gate lengths down to 30 nm are obtained with 8 nm UTB and show excellent short-channel behavior.
Critical behavior of hyper-rayleigh scattering in the centrosymmetric phase of hexagonal barium titanate (1994)

Abstract Critical behavior of hyper-Rayleigh (second-harmonic) scattering was investigated for the first time for a new type of second-order displacive phase transition at Ta = 222 K in the hexagonal barium titanate, which is neither ferroelectric nor proper-ferroelastic in nature. It is found that the scattering intensity in a 90° scattering configuration increases strikingly in such a manner as I2ω ∼ (T-Ta)−2, the square of the generalized susceptibility also observed, as Ta is approached in the centrosymmetric phase, only for those polarizations enabling one to observe the relevant nonpolar soft phonon, while that for other polarizations the 90 intensity remains almost constant. These aspects newly found can be well accounted for with a model that residual point defects acting as strongly localizing “field” should induce microclusters in their vicinity such that development of a locally condensed order-parameter, the square of which I2ω is proportinal to, follows the generalized susceptibility.
WDM channel monitoring and signal power control/equalization using integrated tunable active filters (2002)

To manage a WDM network, the signal at each wavelength channel must be constantly monitored, and the power of each channel should be individually controlled to provide a reliable, user friendly system. Although terminal devices (such as detectors) can monitor, an optical in-line device that can perform both the monitoring and controlling function would be optimal. In this paper, we present the experimental results of using an integrated tunable active filter as just such a useful device.
Specificity Profiling of Dual Specificity Phosphatase Vaccinia VH1-related (VHR) Reveals Two Distinct Substrate Binding Modes* (2013)

Vaccinia VH1-related (VHR) is a dual specificity phosphatase that consists of only a single catalytic domain. Although several protein substrates have been identified for VHR, the elements that control the in vivo substrate specificity of this enzyme remain unclear. In this work, the in vitro substrate specificity of VHR was systematically profiled by screening combinatorial peptide libraries. VHR exhibits more stringent substrate specificity than classical protein-tyrosine phosphatases and recognizes two distinct classes of Tyr(P) peptides. The class I substrates are similar to the Tyr(P) motifs derived from the VHR protein substrates, having sequences of (D/E/ϕ)(D/S/N/T/E)(P/I/M/S/A/V)pY(G/A/S/Q) or (D/E/ϕ)(T/S)(D/E)pY(G/A/S/Q) (where ϕ is a hydrophobic amino acid and pY is phosphotyrosine). The class II substrates have the consensus sequence of (V/A)P(I/L/M/V/F)X1-6pY (where X is any amino acid) with V/A preferably at the N terminus of the peptide. Site-directed mutagenesis and molecular modeling studies suggest that the class II peptides bind to VHR in an opposite orientation relative to the canonical binding mode of the class I substrates. In this alternative binding mode, the Tyr(P) side chain binds to the active site pocket, but the N terminus of the peptide interacts with the carboxylate side chain of Asp(164), which normally interacts with the Tyr(P) + 3 residue of a class I substrate. Proteins containing the class II motifs are efficient VHR substrates in vitro, suggesting that VHR may act on a novel class of yet unidentified Tyr(P) proteins in vivo.
Vaccination with Staphylococcus aureus fibrinogen binding proteins (FgBPs) reduces colonisation of S. aureus in a mouse mastitis model (1994)

A mouse mastitis model was used to study the effect of vaccination with fibrinogen binding proteins and collagen binding protein from Staphylococcus aureus against challenge infection with S. aureus. The mice vaccinated with fibrinogen binding proteins showed reduced rates of mastitis compared with controls. Gross examination of challenged mammary glands of mice showed that the glands of mice immunized with fibronogen binding proteins developed mild intramammary infection or had no pathological changes compared with glands from control mice. Histopathological examination of tissue sections from challenged glands showed that most glands from mice vaccinated with fibrinogen binding protein developed disseminated necrosis or had no pathological changes. A significantly reduced number of bacteria could be recovered in the glands from mice immunized with fibrinogen binding proteins as compared with controls. In a similar study, immunization of mice with collagen binding protein did not induce protection against challenge infection with S. aureus.
[Crystallization of calcium phosphate in the presence of magnesium]. (1993)

Formation and evolution of calcium phosphates are investigated, at 37 degrees C, in urine and aqueous solutions whose concentrations in calcium and magnesium are close to those of urine. Although the solutions are supersaturated with respect to all calcium phosphates, only an amorphous phase (ACP) and brushite (B) precipitate at time zero. Later on, ACP transforms either into whitlockite (W) or into apatite (HAP) depending on the solution composition. Phase transformations are discussed in terms of supersaturation, parameter which includes concentrations and pH. It is also shown that magnesium is a powerful inhibitor of the evolution towards HAP.
Design and Fabrication of Micromachined Membrane (1999)

The principle and characteristics of Micromachined membrane and EPW anisotropic etching are introduced. Silicon nitride corrugated diaphragms and flat diaphragms have been theoretically analyzed. The design methods and results for Micromachined membrane are described.
Incremental Zone Transfer in DNS (1996)

This document proposes extensions to the DNS protocols to provide an incremental zone transfer (IXFR) mechanism.
Power amplifier linearization using memory polynomial predistorter with non-uniform delay taps (2004)

In this paper, a new memory polynomial with nonuniform delay taps is proposed for predistorter linearization of wideband power amplifiers. This method focuses on the effect of nonuniform time delays used in the memory polynomial predistorter (MPPD) functions. It is implemented using advanced design system (ADS/spl reg/) software. Simulation results show that the proposed method can effectively reduce in-band distortion for wideband power amplifiers (PA) that exhibit memory effects. Excellent improvement in intermodulation distortion (IMD) suppression by the new predistortion functions is shown to be due to the use of nonuniform delay taps.
A Comparative Study of Letrozole Vs Clomiphene Citrate as First Line for Anovulatory Infertility– An Institutional Experience (2019)

International audience
Animal mitochondrial genomes (1999)

Animal mitochondrial DNA is a small, extrachromosomal genome, typically approximately 16 kb in size. With few exceptions, all animal mitochondrial genomes contain the same 37 genes: two for rRNAs, 13 for proteins and 22 for tRNAs. The products of these genes, along with RNAs and proteins imported from the cytoplasm, endow mitochondria with their own systems for DNA replication, transcription, mRNA processing and translation of proteins. The study of these genomes as they function in mitochondrial systems-'mitochondrial genomics'-serves as a model for genome evolution. Furthermore, the comparison of animal mitochondrial gene arrangements has become a very powerful means for inferring ancient evolutionary relationships, since rearrangements appear to be unique, generally rare events that are unlikely to arise independently in separate evolutionary lineages. Complete mitochondrial gene arrangements have been published for 58 chordate species and 29 non-chordate species, and partial arrangements for hundreds of other taxa. This review compares and summarizes these gene arrangements and points out some of the questions that may be addressed by comparing mitochondrial systems.
The interpretation of spectral vegetation indexes (1995)

Empirical studies report several plausible correlations between transforms of spectral reflectance, called vegetation indexes, and parameters descriptive of vegetation leaf area, biomass and physiological functioning. However, most indexes can be generalized to show a derivative of surface reflectance with respect to wavelength. This derivative is a function of the optical properties of leaves and soil particles. In the case of optically dense vegetation, the spectral derivative, and thus the indexes, can be rigorously shown to be indicative of the abundance and activity of the absorbers in the leaves. Therefore, the widely used broad-band &near-infrared vegetation indexes are a measure of chlorophyll abundance and energy absorption.
Corn Marketing, Processing, and Utilization (1988)

The corn grown by U.S. farmers is transferred to the final users through a sophisticated marketing network. Marketing involves physical facilities for drying and conditioning, handling, storing, transporting, pricing, and processing. The wet milling process, from its modest beginning about 1840, has developed into a highly sophisticated means of separating the components of the corn kernel by chemical and physical methods into a multitude of useful products. Since that date, the wet milling industry has experienced continued improvement in operating efficiency and product quality, continued expansion in variety and utility of products, and growing demand for its products. The combination of continuous flow, precise control, closed stainless steel tanks, and careful sanitation has transformed "corn grinding" into a scientific food-processing operation. Continuous progress has been made over many years by the wet milling industry to minimize water and air pollution.
Enhancing radiosensitivity of melanoma cells through very high dose rate pulses released by a plasma focus device (2018)

Radiation therapy is a useful and standard tumor treatment strategy. Despite recent advances in delivery of ionizing radiation, survival rates for some cancer patients are still low because of recurrence and radioresistance. This is why many novel approaches have been explored to improve radiotherapy outcome. Some strategies are focused on enhancement of accuracy in ionizing radiation delivery and on the generation of greater radiation beams, for example with a higher dose rate. In the present study we proposed an in vitro research of the biological effects of very high dose rate beam on SK-Mel28 and A375, two radioresistant human melanoma cell lines. The beam was delivered by a pulsed plasma device, a "Mather type" Plasma Focus for medical applications. We hypothesized that this pulsed X-rays generator is significantly more effective to impair melanoma cells survival compared to conventional X-ray tube. Very high dose rate treatments were able to reduce clonogenic efficiency of SK-Mel28 and A375 more than the X-ray tube and to induce a greater, less easy-to-repair DNA double-strand breaks. Very little is known about biological consequences of such dose rate. Our characterization is preliminary but is the first step toward future clinical considerations.
Prognosis of stage III colorectal carcinomas with FOLFOX adjuvant chemotherapy can be predicted by molecular subtype (2017)

Individualizing adjuvant chemotherapy is important in patients with advanced colorectal cancers (CRCs), and the ability to identify molecular subtypes predictive of good prognosis for stage III CRCs after adjuvant chemotherapy could be highly beneficial. We performed microarray-based gene expression analysis on 101 fresh-frozen primary samples from patients with stage III CRCs treated with FOLFOX adjuvant chemotherapy and 35 matched non-neoplastic mucosal tissues. CRC samples were classified into four molecular subtypes using nonnegative matrix factorization, and for comparison, we also grouped CRC samples using the proposed consensus molecular subtypes (CMSs). Of the 101 cases, 80 were classified into a CMS group, which shows a 79% correlation between the CMS classification and our four molecular subtypes. We found that two of our subtypes showed significantly higher disease-free survival and overall survival than the others. Group 2, in particular, which showed no disease recurrence or death, was characterized by high microsatellite instability (MSI-H, 6/21), abundant mucin production (12/21), and right-sided location (12/21); this group strongly correlated with CMS1 (microsatellite instability immune type). We further identified the molecular characteristics of each group and selected 10 potential biomarker genes from each. When these were compared to the previously reported molecular classifier genes, we found that 31 out of 40 selected genes were matched with those previously reported. Our findings indicate that molecular classification can reveal specific molecular subtypes correlating with clinicopathologic features of CRCs and can have predictive value for the prognosis for stage III CRCs with FOLFOX adjuvant chemotherapy.
Relationship of glycosylation to de novo thyroid-stimulating hormone biosynthesis and secretion by mouse pituitary tumor cells. (1980)

Ratios unreliable because of sample counting error >10R.
Crystal-Induced Inflammation of the Joints (1970)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
New-Onset Diabetes and Risk of All-Cause and Cardiovascular Mortality (2006)

Our findings indicate that there may be a mortality differential soon after diabetes onset in older adults and suggest that long-term macrovascular damage from atherosclerosis may not be primarily responsible for increased risk.
Hypothesis: Angiogenesis cytokines in high altitude cerebral oedema (1995)

Abstracted from Severinghaus J W. Hypothetic roles of angiogenesis, osmotic swelling and ischemia in high altitude cerebral edema. J Appl Physiol 1995: (in press).
Dihydro-platinum(II) and related complexes (1974)

Stable platinum(II) dihydrides trans-[PtH2L12] and monohydrides [PtH(P–C)L](L = a bulky tertiary phosphine, P–C = a metallated tertiary phosphine) are described; a previous claim to have made such dihydrides is shown to be wrong.
Selective estrogen receptor modulation: a personal perspective. (2001)

Professor Paul Ehrlich is the father of experimental chemotherapy. During the first decade of the 20th Century, he reasoned that compounds could be synthesized to exhibit selective toxicity on a parasite without affecting the host. The synthesis, laboratory evaluation, and clinical development of
Hybrid Optical Fibers – An Innovative Platform for In‐Fiber Photonic Devices (2015)

The field of hybrid optical fibers is one of the most active research areas in current fiber optics and has the vision of integrating sophisticated materials inside fibers, which are not traditionally used in fiber optics. Novel in‐fiber devices with unique properties have been developed, opening up new directions for fiber optics in fields of critical interest in modern research, such as biophotonics, environmental science, optoelectronics, metamaterials, remote sensing, medicine, or quantum optics. Here the recent progress in the field of hybrid optical fibers is reviewed from an application perspective, focusing on fiber‐integrated devices enabled by including novel materials inside polymer and glass fibers. The topics discussed range from nanowire‐based plasmonics and hyperlenses, to integrated semiconductor devices such as optoelectronic detectors, and intense light generation unlocked by highly nonlinear hybrid waveguides.
The differential inhibitory effect of lymphotoxin and immune interferon on normal and malignant lymphoid cells. (1985)

Supernatants containing lymphotoxin (LT) and immune interferon (IFN-gamma) or IFN-gamma alone were produced by antigen-stimulated murine T cell clones. These lymphokine preparations as well as cloned recombinant murine IFN-gamma (Genentech) were tested for antiproliferative activity on a variety of murine T, B, macrophage, and mastocytoma tumors and on T cell clones and LPS-stimulated B cells. The growth of every cell line tested was susceptible to the LT-containing supernatants. Cloned recombinant murine IFN-gamma inhibited the growth of A9 fibroblasts but not L929 cells. Neither the cloned murine IFN-gamma nor that produced by a T cell clone had any appreciable effect on the lymphoid cells except for one B cell lymphoma, A20. The sensitivity of nontransformed T and B cells to LT indicates that this lymphokine may play an immunoregulatory role. Indeed, the T cells that produce LT are sensitive to its cytotoxic activity and, therefore, regulate themselves. The differential inhibitory effects of LT and IFN-gamma on lymphoid target cells allow us to distinguish between preparations that contain IFN-gamma alone and those that contain LT and IFN-gamma. The susceptibility of lymphoid tumors to the antiproliferative activity of the LT-containing preparations indicates that LT either alone or together with IFN-gamma may be useful in tumor therapy.
Secretion of Human Interferon-α Induced by Using Secretion Vectors Containing a Promoter and Signal Sequence of Alkaline Phosphatase Gene of Escherichia coli (1985)

We constructed a new vector containing the promoter and the signal sequence of E. coli phoA gene, the structural gene for the periplasmic alkaline phosphatase. One of the most useful characteristics of this vector is the unique HindIII restriction site located just at the end of the phoA signal sequence. This restriction site was generated by oligonucleotide-directed site-specific mutagenesis without changing the amino acid sequence of the signal peptide. Any kind of foreign structural gene can be easily inserted into the HindIII site by using synthetic oligonucleotides to construct a hybrid gene which has neither an extra sequence nor a deletion between the phoA signal sequence and the foreign structural gene. Human alpha-interferon gene was inserted into this HindIII site. When this hybrid gene was expressed under the control of the phoA promoter region, a low but significant activity was recovered in the cold water wash of the cells after an osmotic shock procedure.
THE ROLE OF NUCLEIC ACID AMPLIFICATION AND DETECTION IN THE CLINICAL MICROBIOLOGY LABORATORY (1996)

Clinical microbiology is in the midst of a new era. Methodology that is based on nucleic acid detection has slowly appeared in the diagnostic laboratory, and is revolutionizing our ability to assist physicians in the diagnosis and management of patients suffering from infectious diseases. Much like the introduction of immunoassays built around hybridoma technology in the 1980s, considerable doubt and promise exist hand in hand in the 1990s. Conventional testing that is technically straight forward, informative, and timely will always be a part of clinical microbiology; however, considerable room for improvement exists with organisms/diseases for which laboratory methods are limited. Nucleic acid methodology will have its greatest and long-awaited impact in this arena.
[Expression and clinicopathological significance of OPN and CD44v6 in lung cancer]. (2007)

The co-expression of OPN and CD44v6 may be involved in progression and metastasis of lung cancer. The interrelationship of OPN and CD44v6 was coordinative with development and metastasis of lung cancer. It might be helpful to predict the metastasis and prognosis of NSCLC.
[Studies on the methods of mating test for Cryptococcus neoformans]. (2001)

Six media (MA:Mating agar, HA:Hay agar, HCA:Hay cube agar, RSA:Rice shell agar, IHA:additional nutrition in HA and SDA:Sabouraudia dextrose agar) were compared for their efficiencies of the mating test for Cryptococcus neoformans. The positive rates in 2-week-cultivation were 95% (HCA and RSA), 86% (HA), 38% (MA and SDA) and 24% (IHA). The streaking inoculation was equally replaced by the dot inoculation for the mating tests. However, the dot method saves much more materials, and is suitable for testing in large number of isolates. Additionally, the precultivation of the tester and tested isolates in broth medium (YMPDB) could enhance the positive mating rates.
HERITABLE CHARACTERS OF MAIZE (1930)

Journal Article HERITABLE CHARACTERS OF MAIZE: XXXV-Male Sterile Get access W.R. SINGLETON, W.R. SINGLETON Connecticut Agricultural Experiment Station,New Haven, Conn. Search for other works by this author on: Oxford Academic PubMed Google Scholar D.F. JONES D.F. JONES Connecticut Agricultural Experiment Station,New Haven, Conn. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 21, Issue 6, June 1930, Pages 266–268, https://doi.org/10.1093/oxfordjournals.jhered.a103340 Published: 01 June 1930
The trusted path between SMITE and the user (2003)

If signaling channels can only be driven by a trusted path, they cannot be exploited by trojan horses in untrusted software. To this end, the SMITE secure computer system provides a general-purpose trusted path, based on a screen editor, which would act as the users' normal interface to the system. The feasibility of the approach relies on the use of a sympathetic computer architecture, which supports a fine grain of protection. The authors describe the trusted path and the user interface of the SMITE system. They discuss the formal specification of the display functions. They examine the use of SMITE for high-assurance applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>