gebhart/patrepeval huggingface dataset:
Effect of hypothermia on the coagulation cascade (1992)

The series of enzymatic reactions of the coagulation cascade are strongly inhibited by hypothermia, as demonstrated by the dramatic prolongation of prothrombin time and partial thromboplastin time tests at hypothermic deviations from normal temperature in a situation where factor levels were all known to be normal. Clinicians who deal with critically ill massively transfused hypothermic patients all recognize the inevitable appearance of a coagulopathy that has a multifactorial origin. Unless specifically considered, the contribution of hypothermia to the hemorrhagic diathesis may be overlooked since coagulation testing is performed at 37 degrees C, rather than at the patient's actual in vivo temperature.
Effects of host plant environment and Ustilago maydis infection on the fungal endophyte community of maize (Zea mays) (2008)

The focus of many fungal endophyte studies has been how plants benefit from endophyte infection. Few studies have investigated the role of the host plant as an environment in shaping endophyte community diversity and composition. The effects that different attributes of the host plant, that is, host genetic variation, host variation in resistance to the fungal pathogen Ustilago maydis and U. maydis infection, have on the fungal endophyte communities in maize (Zea mays) was examined. The internal transcribed spacer (ITS) region of the rDNA was sequenced to identify fungi and the endophyte communities were compared in six maize lines that varied in their resistance to U. maydis. It was found that host genetic variation, as determined by maize line, had significant effects on species richness, while the interactions between line and U. maydis infection and line and field plot had significant effects on endophyte community composition. However, the effects of maize line were not dependent on whether lines were resistant or susceptible to U. maydis. Almost 3000 clones obtained from 58 plants were sequenced to characterize the maize endophyte community. These results suggest that the endophyte community is shaped by complex interactions and factors, such as inoculum pool and microclimate, may be important.
Warfarin Necrosis of the Skin and Subcutaneous Tissue of the Male External Genitalia (1983)

Gangrene of the male external genitalia is an uncommon urologic problem with a limited differential diagnosis. To the etiologic spectrum we add warfarin-induced penile gangrene. Pathophysiology, diagnosis and treatment are discussed.
A 333 MHz, 20 mW, 18 ps resolution digital DLL using current-controlled delay with parallel variable resistor DAC (PVR-DAC) (2002)

A new Delay Locked Loop (DLL) using a Digital-to-Analog Converter with the Parallel Variable Resister (PVR-DAC) has been developed. The PVR-DAC successfully manages the current controlled-delay element (CCDE) and achieves a fine time-based resolution. The DLL adopting PVR-DAC has been simulated. It realizes a time-based resolution of 18 ps, an operation frequency range of 143 MHz through 333 MHz, with the maximum power consumption of 20 mW at 1.5 V, and also achieves the small circuit area of 0.5 mm/sup 2/.
A Low-Power Integrated Circuit for a Wireless 100-Electrode Neural Recording System (2007)

Recent work in field of neuroprosthetics has demonstrated that by observing the simultaneous activity of many neurons in specific regions of the brain, it is possible to produce control signals that allow animals or humans to drive cursors or prosthetic limbs directly through thoughts. As neuroprosthetic devices transition from experimental to clinical use, there is a need for fully-implantable amplification and telemetry electronics in close proximity to the recording sites. To address these needs, we developed a prototype integrated circuit for wireless neural recording from a 100-channel microelectrode array. The design of both the system-level architecture and the individual circuits were driven by severe power constraints for small implantable devices; chronically heating tissue by only a few degrees Celsius leads to cell death. Due to the high data rate produced by 100 neural signals, the system must perform data reduction as well. We use a combination of a low-power ADC and an array of "spike detectors" to reduce the transmitted data rate while preserving critical information. The complete system receives power and commands (at 6.5 kb/s) wirelessly over a 2.64-MHz inductive link and transmits neural data back at a data rate of 330 kb/s using a fully-integrated 433-MHz FSK transmitter. The 4.7times5.9 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> chip was fabricated in a 0.5-mum 3M2P CMOS process and consumes 13.5 mW of power. While cross-chip interference limits performance in single-chip operation, a two-chip system was used to record neural signals from a Utah Electrode Array in cat cortex and transmit the digitized signals wirelessly to a receiver
Local Therapy and Survival in Breast Cancer (2007)

Some investigators have viewed breast cancer as a local disease that then spreads; others have seen it as a systemic disease from the start. This review argues for another view, since the failure to achieve initial local control allows some tumors to disseminate later, reducing a patient's chance of long-term survival. Recent evidence supports a larger role for aggressive, local therapy for breast cancer.
A matching method for improving covariate balance in cost‐effectiveness analyses (2011)

In cost-effectiveness analyses (CEA) that use randomized controlled trials (RCTs), covariates of prognostic importance may be imbalanced and warrant adjustment. In CEA that use non-randomized studies (NRS), the selection on observables assumption must hold for regression and matching methods to be unbiased. Even in restricted circumstances when this assumption is plausible, a key concern is how to adjust for imbalances in observed confounders. If the propensity score is misspecified, the covariates in the matched sample will be imbalanced, which can lead to conditional bias. To address covariate imbalance in CEA based on RCTs and NRS, this paper considers Genetic Matching. This matching method uses a search algorithm to directly maximize covariate balance. We compare Genetic and propensity score matching in Monte Carlo simulations and two case studies, CEA of pulmonary artery catheterization, based on an RCT and an NRS. The simulations show that Genetic Matching reduces the conditional bias and root mean squared error compared with propensity score matching. Genetic Matching achieves better covariate balance than the unadjusted analyses of the RCT data. In the NRS, Genetic Matching improves on the balance obtained from propensity score matching and gives substantively different estimates of incremental cost-effectiveness. We conclude that Genetic Matching can improve balance on measured covariates in CEA that use RCTs and NRS, but with NRS, this will be insufficient to reduce bias; the selection on observables assumption must also hold.
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770 (2009)

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved in salt and fluid transport in multiple organs, including the lung. Most CF mutations either reduce the number of CFTR channels at the cell surface (e.g., synthesis or processing mutations) or impair channel function (e.g., gating or conductance mutations) or both. There are currently no approved therapies that target CFTR. Here we describe the in vitro pharmacology of VX-770, an orally bioavailable CFTR potentiator in clinical development for the treatment of CF. In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. Furthermore, VX-770 reduced excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures. These results support the hypothesis that pharmacological agents that restore or increase CFTR function can rescue epithelial cell function in human CF airway.
Distributed packet rewriting and its application to scalable server architectures (2002)

To construct high performance Web servers, system builders are increasingly turning to distributed designs. An important challenge that arises in such designs is the need to direct incoming connections to individual hosts. Previous methods for connection routing (layer 4 switching) have employed a centralized node to handle all incoming requests. In contrast, we propose a distributed approach, called distributed packet rewriting (DPR), in which all hosts of the distributed system participate in connection routing. DPR promises better scalability and fault-tolerance than the current practice of using centralized special-purpose connection routers. We describe the implementation of four variants of DPR and compare their performance. We show that DPR provides performance comparable to centralized alternatives, measured in terms of throughput and delay. Also, we show that DPR enhances the scalability of Web server clusters by eliminating the performance bottleneck exhibited when centralized connection routing techniques are utilized.
Determination of citrate in urine by simple direct photometry. (1987)

Journal Article Determination of citrate in urine by simple direct photometry. Get access A Millán, A Millán Search for other works by this author on: Oxford Academic Google Scholar A Conte, A Conte Search for other works by this author on: Oxford Academic Google Scholar A García-Raso, A García-Raso Search for other works by this author on: Oxford Academic Google Scholar F Grases F Grases Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 33, Issue 7, 1 July 1987, Pages 1259–1260, https://doi.org/10.1093/clinchem/33.7.1259a Published: 01 July 1987
Analysis of Notch Lacking the Carboxyl Terminus Identified in Drosophila Embryos (2000)

The cell surface receptor Notch is required during development of Drosophila melanogaster for differentiation of numerous tissues. Notch is often required for specification of precursor cells by lateral inhibition and subsequently for differentiation of tissues from these precursor cells. We report here that certain embryonic cells and tissues that develop after lateral inhibition, like the connectives and commissures of the central nervous system, are enriched for a form of Notch not recognized by antibodies made against the intracellular region carboxy-terminal of the CDC10/Ankyrin repeats. Western blotting and immunoprecipitation analyses show that Notch molecules lacking this region are produced during embryogenesis and form protein complexes with the ligand Delta. Experiments with cultured cells indicate that Delta promotes accumulation of a Notch intracellular fragment lacking the carboxyl terminus. Furthermore, Notch lacking the carboxyl terminus functions as a receptor for Delta. These results suggest that Notch activities during development include generation and activity of a truncated receptor we designate NDeltaCterm.
Supplementation of Intracellular XylR Leads to Coutilization of Hemicellulose Sugars (2012)

Escherichia coli has the potential to be a powerful biocatalyst for the conversion of lignocellulosic biomass into useful materials such as biofuels and polymers. One important challenge in using E. coli for the transformation of biomass sugars is diauxie, or sequential utilization of different types of sugars. We demonstrate that, by increasing the intracellular levels of the transcription factor XylR, the preferential consumption of arabinose before xylose can be eliminated. In addition, XylR augmentation must be finely tuned for robust coutilization of these two hemicellulosic sugars. Using a novel technique for scarless gene insertion, an additional copy of xylR was inserted into the araBAD operon. The resulting strain was superior at cometabolizing mixtures of arabinose and xylose and was able to produce at least 36% more ethanol than wild-type strains. This strain is a useful starting point for the development of an E. coli biocatalyst that can simultaneously convert all biomass sugars.
The Tortuous Road to an Ideal CGRP Function Blocker for the Treatment of Migraine (2008)

The critical role of Calcitonin Gene-Related Peptide (CGRP) in migraine has been validated, with two small molecule CGRP antagonists BIBN4096BS and MK-0974 demonstrating efficacy in the reversal of acute migraine attack. Multiple approaches have been taken to find the ideal agent that most effectively inhibits CGRP's function. Here, we have summarized the progress made in recent years, including the identification and optimization of an orally bioavailable small molecule CGRP receptor antagonist. We also describe other interventions such as scavenging of CGRP itself. The advantages and disadvantages of these distinct approaches are discussed.
Recent Advances in Nano Patterning and Nano Imprint Lithography for Biological Applications (2014)

Nano patterning and Nanoimprint lithography [NIL] has advanced to great heights in recent years. Customizing the surface at micro and nano scale is of great demand. It facilitates the handling and working at micro and nano scale level. Its applications towards medical field are growing day by day. Precise surface patterning with nanometer resolution has great potential in many medical and biological applications. It also provides a platform for fundamental studies of molecular and cell biology. This review article comprises of current trends and future scope of nano patterning and NIL. In this article we particularly focus on biological applications.
Lifting-Based Directional DCT-Like Transform for Image Coding (2007)

Traditional 2D DCT implemented by separable 1D transform in horizontal and vertical directions does not take image orientation features in a local window into account. To improve it, we propose to introduce directional primary operations to the lifting-based DCT and thereby derive a new directional DCT-like transform. A JPEG-wise image coding scheme is also proposed to evaluate the performance of the proposed directional DCT-like transform. In this scheme, each 8times8 block can be transformed along different direction in order to better adapt to local orientation properties of image. The experimental results show that the performance of the proposed directional DCT can dramatically outperform the conventional DCT up to 2 dB even without modifying entropy coding.
Phosphoinositide-dependent Kinase PDK1 in the Regulation of Ca<sup>2+</sup> Entry into Mast Cells (2010)

The function of mast cells is modified by the phosphoinositol-3 (PI3)-kinase pathway. The kinase signals partially through the phosphoinositide-dependent kinase PDK1, which on the one hand activates the serum- and glucocorticoid- inducible kinase SGK1 and on the other hand activates protein kinase PKCδ. SGK1 participates in the stimulation of Ca(2+) entry and degranulation, PKCδ inhibits degranulation. The present experiments explored the role of PDK1 in mast cell function. As mice completely lacking PDK1 are not viable, experiments have been performed in mast cells isolated from bone marrow (BMMCs) of PDK1 hypomorphic mice (pdk1(hm)) and their wild-type littermates (pdk1(wt)). Antigen stimulation via the FceRI receptor was followed by Ca(2+) entry leading to increase of cytosolic Ca(2+) activity in pdk1(wt) BMMCs, an effect significantly blunted in pdk1(hm) BMMCs. In contrast, Ca(2+) release from intracellular stores was not different between BMMCs of the two genotypes. The currents through Ca(2+)-activated K(+) channels following antigen exposure were again significantly larger in pdk1(wt) than in pdk1(hm) cells. The Ca(2+) ionophore ionomycin (1 μM) increased the K(+) channel conductance to similar values in both genotypes. β-hexosaminidase and histamine release were similar in pdk1(wt) BMMCs and pdk1(hm) BMMCs. PKCδ inhibitor rottlerin increased β-hexosaminidase release in pdk1(wt) BMMCs but not in pdk1(hm) BMMCs. Phosphorylation of PKCδ and of the SGK1 target NDRG1, was stimulated by the antigen in pdk1(wt) but not in pdk1(hm) cells. The observations reveal a role for PDK1 in the regulation of Ca(2+) entry into and degranulation of murine mast cells.
A Comparative Study of Polar Code Constructions for the AWGN Channel (2015)

We present a comparative study of the performance of various polar code constructions in an additive white Gaussian noise (AWGN) channel. A polar code construction is any algorithm that selects $K$ best among $N$ possible polar bit-channels at the design signal-to-noise-ratio (design-SNR) in terms of bit error rate (BER). Optimal polar code construction is hard and therefore many suboptimal polar code constructions have been proposed at different computational complexities. Polar codes are also non-universal meaning the code changes significantly with the design-SNR. However, it is not known which construction algorithm at what design-SNR constructs the best polar codes. We first present a comprehensive survey of all the well-known polar code constructions along with their full implementations. We then propose a heuristic algorithm to find the best design-SNR for constructing best possible polar codes from a given construction algorithm. The proposed algorithm involves a search among several possible design-SNRs. We finally use our algorithm to perform a comparison of different construction algorithms using extensive simulations. We find that all polar code construction algorithms generate equally good polar codes in an AWGN channel, if the design-SNR is optimized.
Structure and use of a library for physical systems models (1995)

The availability of reusable and sharable models of phys-ical systems will be a major advance in Computer Aided Engineering. Therefore, a generic framework for storing and retrieving public and private model data is needed. Our thesis is that such a framework must be based on a differenti-ation between three different levels of abstraction, which we define as engineering components, conceptual descriptions in terms of physical processes, and mathematical relations. Our approach is centered around the bond graph language, which provides the conceptual link between components and mathematical relations, a.o., in the field of mechatronics. When constructing a model, a system is decomposed down to an appropriate level of granularity. Each com-ponent is associated with one of a number of alternative conceptual descriptions (bond graphs), one of which is to be selected. Concepts (i.e. bond graph elements) in turn are further specified by selection from a number of alternative mathematical relationships. Moreover, previously assem-bled models based on the generic building blocks can also be stored in the library. In this way, models with differ-ent levels of detail and validation status can be assembled. In this paper we describe how this framework supports the modeling process. An example session shows the route a modeler might follow to assemble the model of his/her needs.
Towards Effective Trust-Based Packet Filtering in Collaborative Network Environments (2017)

Overhead network packets are a big challenge for intrusion detection systems (IDSs), which may increase system burden, degrade system performance, and even cause the whole system collapse, when the number of incoming packets exceeds the maximum handling capability. To address this issue, packet filtration is considered as a promising solution, and our previous research efforts have proven that designing a trust-based packet filter was able to refine unwanted network packets and reduce the workload of a local IDS. With the development of Internet cooperation, collaborative intrusion detection environments (e.g., CIDNs) have been developed, which allow IDS nodes to collect information and learn experience from others. However, it would not be effective for the previously built trust-based packet filter to work in such a collaborative environment, since the process of trust computation can be easily compromised by insider attacks. In this paper, we adopt the existing CIDN framework and aim to apply a collaborative trust-based approach to reduce unwanted packets. More specifically, we develop a collaborative trust-based packet filter, which can be deployed in collaborative networks and be robust against typical insider attacks (e.g., betrayal attacks). Experimental results in various simulated and practical environments demonstrate that our filter can perform effectively in reducing unwanted traffic and can defend against insider attacks through identifying malicious nodes in a quick manner, as compared to similar approaches.
Syncytium-Inhibiting Monoclonal Antibodies Produced against Human T-Cell Lymphotropic Virus Type 1-Infected Cells Recognize Class II Major Histocompatibility Complex Molecules and Block by Protein Crowding (1998)

Four new monoclonal antibodies (MAbs) that inhibit human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation were produced by immunizing BALB/c mice with HTLV-1-infected MT2 cells. Immunoprecipitation studies and binding assays of transfected mouse cells showed that these MAbs recognize class II major histocompatibility complex (MHC) molecules. Previously produced anti-class II MHC antibodies also blocked HTLV-1-induced cell fusion. Coimmunoprecipitation and competitive MAb binding studies indicated that class II MHC molecules and HTLV-1 envelope glycoproteins are not associated in infected cells. Anti-MHC antibodies had no effect on human immunodeficiency virus type 1 (HIV-1) syncytium formation by cells coinfected with HIV-1 and HTLV-1, ruling out a generalized disruption of cell membrane function by the antibodies. High expression of MHC molecules suggested that steric effects of bound anti-MHC antibodies might explain their inhibition of HTLV-1 fusion. An anti-class I MHC antibody and a polyclonal antibody consisting of several nonblocking MAbs against other molecules bound to MT2 cells at levels similar to those of class II MHC antibodies, and they also blocked HTLV-1 syncytium formation. Dose-response experiments showed that inhibition of HTLV-1 syncytium formation correlated with levels of antibody bound to the surface of infected cells. The results show that HTLV-1 syncytium formation can be blocked by protein crowding or steric effects caused by large numbers of immunoglobulin molecules bound to the surface of infected cells and have implications for the structure of the cellular HTLV-1 receptor(s).