gebhart/patrepeval huggingface dataset:
Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin C Conjugate and the Carboxymethyl-chitin-Mitomycin C Conjugate. (1993)

The conjugate between N-succinyl-chitosan (Suc-chitosan) and mitomycin C (MMC), named Suc-chitosan-MMC, and that between carboxymethyl-chitin (CM-chitin) and MMC, named CM-chitin-MMC, were investigated in vivo. As for the intraperitoneal drug administration using rats, the order of the maximum blood concentration of MMC was unconjugated MMC > CM-chitin-MMC > Suc-chitosan-MMC. The plasma concentration of MMC for Suc-chitosan-MMC was maintained at an almost constant level over 24 h. Pharmacokinetic analysis of each plasma concentration indicated that for each conjugate, the in vitro drug release reported previously was useful for the approximate estimation of the in vivo regeneration of MMC. The chemotherapeutic effect of MMC and the conjugates was investigated using mice bearing L1210 leukemia or B16 melanoma. Concerning antitumor activity against L1210 leukemia, the conjugates exhibited a marked effect at higher doses, and their effect increased even in the dose range where the effect of MMC decreased. MMC and the conjugates exhibited a good growth-inhibitory effect against B16 melanoma. Complete inhibition of growth of B16 melanoma was observed at the dose of 10 mg eq MMC/kg for CM-chitin-MMC.
The Possibility of Common Amino Acid Sequences in High-Sulphur Protein Fractions from Wool (1969)

S-Carboxymethyl derivatives of the high-sulphur components of reduced Merino wool have been subdivided by chromatography into 17 fractions, the amino acid compositions of which are reported. Tryptic, chymotryptic, and thermolysin digests of each fraction have been studied by high-voltage paper electrophoresis at pH 3·5 and 6·5. The results suggest that the high-sulphur proteins consist of families of proteins probably containing common structural features. Evidence is presented that the heterogeneity of high-sulphur proteins is not artefactual.
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility (2002)

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2 that are involved in breast cancer susceptibility. The goal of this review is the discovery of polymorphisms that are either associated with breast cancer or that are in strong linkage disequilibrium with breast cancer causing variants. An association with breast cancer at a 5% significance level was found for 13 polymorphisms in 10 genes described in more than one breast cancer study. Our data will help focus on the further analysis of genetic polymorphisms in populations of appropriate size, and especially on the combinations of such polymorphisms. This will facilitate determination of population attributable risks, understanding of gene-gene interactions, and improving estimates of genetic cancer risks.
Length and Weight Relationships for 31 Species of Fishes Caught by Trawl Off the Arabian Sea Coast of Oman (2008)

Length and weight measurement for 31f ish species encountered in the Arabian Sea , o f f t h e Oma n Coast, were collected by demersal trawling during March 2007 and March 2008. A total of 3,261 specimens were measured for total length, or fork length, where appropriate, and green weight. Several commonly caught commercial species undergo onboard processing (dressing) prior to packaging, and dressed weight to green weight regressions and conversion factors were calculated for 12 of these species. The relationships obtained in this study were compared with those of other studies for the same fish species. These data are fundamental to understanding the biological parameters of fishes, and can be applied to fisheries stock assessment and management models.
Ion Channel-Forming Alamethicin Is a Potent Elicitor of Volatile Biosynthesis and Tendril Coiling. Cross Talk between Jasmonate and Salicylate Signaling in Lima Bean (2001)

Alamethicin (ALA), a voltage-gated, ion channel-forming peptide mixture from Trichoderma viride, is a potent elicitor of the biosynthesis of volatile compounds in lima bean (Phaseolus lunatus). Unlike elicitation with jasmonic acid or herbivore damage, the blend of substances emitted comprises only the two homoterpenes, 4,11-dimethylnona-1,3,7-triene and 4,8,12-trimethyltrideca-1,3,7,11-tetraene, and methyl salicylate. Inhibition of octadecanoid signaling by aristolochic acid and phenidone as well as mass spectrometric analysis of endogenous jasmonate demonstrate that ALA induces the biosynthesis of volatile compounds principally via the octadecanoid-signaling pathway (20-fold increase of jasmonic acid). ALA also up-regulates salicylate biosynthesis, and the time course of the production of endogenous salicylate correlates well with the appearance of the methyl ester in the gas phase. The massive up-regulation of the SA-pathway (90-fold) interferes with steps in the biosynthetic pathway downstream of 12-oxophytodienoic acid and thereby reduces the pattern of emitted volatiles to compounds previously shown to be induced by early octadecanoids. ALA also induces tendril coiling in various species like Pisum, Lathyrus, and Bryonia, but the response appears to be independent from octadecanoid biosynthesis, because inhibitors of lipoxygenase and phospholipase A(2) do not prevent the coiling reaction.
Magnetic Liquid Marbles: Manipulation of Liquid Droplets Using Highly Hydrophobic Fe3O4 Nanoparticles (2009)

Magnetic liquid marbles exhibit a remarkable ability to be opened (see image) and closed reversibly under the action of a magnetic field. Liquid can be either extracted from or added to the opened liquid marble simply with a capillary needle. Two opened liquid marbles can also be coalesced into a larger one. The magnetic liquid marbles can be maneuvered two- and three-dimensionally. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Suppression of Fiber Nonlinearities and PMD in Coded-Modulation Schemes With Coherent Detection by Using Turbo Equalization (2009)

We propose a maximum a posteriori probability (MAP) turbo equalizer based on the sliding-window multilevel Bahl–Cocke–Jelinek–Raviv algorithm. This scheme is suitable for simultaneous nonlinear and linear impairment mitigation in multilevel coded-modulation schemes with coherent detection. The proposed scheme employs large-girth quasi-cyclic LDPC codes as channel codes. We demonstrate the efficiency of this method in dealing with fiber nonlinearities by performing Monte Carlo simulations. In addition, we provide the experimental results that demonstrate the efficiency of this method in dealing with polarization mode dispersion. We also study the ultimate channel capacity limits, assuming an independent identically distributed source.
In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits (1993)

Using a novel in vitro selection/amplification technique, we have recently identified a new class of thrombin inhibitors based on single-stranded DNA oligonucleotides. One oligonucleotide, GGTTGGTGTGGTTGG (thrombin, aptamer), showed potent anticoagulant activity in vitro. We have initiated pharmacologic studies in cynomolgus monkeys to study the thrombin aptamer's in vivo anticoagulant properties. Upon infusion of the thrombin aptamer, anticoagulation was rapidly achieved, with a plateau reached within 10 minutes. There was a linear dose-response relationship between thrombin aptamer infusion rate and prolongation of plasma prothrombin time. Ten minutes after the infusion was stopped, no prolongation of prothrombin time was observed, indicating that the thrombin aptamer has an extremely short in vivo half-life, estimated to be 108 +/- 14 seconds. In addition, inhibition of thrombin-induced platelet aggregation in platelet-rich plasma was observed ex vivo without an effect on collagen-induced aggregation, indicating that the inhibition was specific for thrombin and not due to a nonspecific inhibitory effect on platelets. To exploit the short in vivo half-life of the thrombin aptamer, its ability to achieve regional anticoagulation in an extracorporeal hemofiltration circuit in sheep was tested. Doubling of the prothrombin time in the circuit was observed, whereas the systemic prothrombin time was minimally prolonged. We conclude that the thrombin aptamer is a potent anticoagulant in vivo, and specifically inhibits thrombin-induced platelet aggregation ex vivo. The rapid onset of action and short half-life in vivo suggest that the thrombin aptamer may be useful in anticoagulation with extracorporeal circuits and may have distinct advantages in certain acute clinical settings.
Preface: Guidelines for the Prevention of Infections Associated With Combat-Related Injuries: 2011 Update (2011)

Infection is an all-too-common complication of combat-related injuries. The Prevention of Combat-Related Infections Guidelines Panel was established to review pertinent data that have become available since 2007 on prevention of these infections and to update guidelines by this group previously published in 2008. These updated guidelines, Guidelines for the Prevention of Infections Associated With Combat-related Injuries: 2011 Update, are published in this Journal of Trauma supplement along with evidence-based medicine reviews of the supporting data.
An organic geochemical investigation of the practice of manuring at a Minoan site on Pseira Island, Crete (2001)

Lipid components in a soil profile developed in an agricultural terrace at a Minoan site on Pseira Island, Crete, were analyzed to determine whether the practice of manuring in antiquity, as inferred by distributional and temporal sherd scatter, could be confirmed through the use of biomarker compounds as proxies for manuring. Analysis of total organic carbon and the abundance of n-alkyl lipids (n-alkanols and fatty acids) demonstrated that while the upper part of the soil profile had received more recent inputs of vegetation-derived organic matter, the deeper archaeological strata remained essentially undisturbed. Further analysis of 5β-stanols, sterol components which may be utilized as fecal biomarkers, revealed a signal indicative of manuring, with human or porcine-derived fecal material, in the lower 15 cm of the profile. Additional appraisal of epicoprostanol abundance inferred the possible practice of composting in later periods. This study represents a detection of manuring, in the oldest samples to date, using organic geochemical methods. © 2001 John Wiley & Sons, Inc.
Cerebral Blood Flow Velocity Regulation in Preterm Infants (1991)

Cerebrovascular autoregulation is the mechanism by which changes in cerebral blood flow are prevented during fluctuations in mean arterial blood pressure. Doppler ultrasound measurement of cerebral blood flow velocity provides a reliable indirect technique to estimate cerebral blood flow. In 48 stable preterm infants less than or equal to 32 weeks gestation, we studied the mean flow velocity in the pericallosal artery at 12, or at 12 and 72 h of age with two-dimensional/pulsed Doppler ultrasound and correlated the mean flow velocity with the simultaneously obtained mean arterial blood pressure values. Mean flow velocity was stable at a mean arterial blood pressure ranging from 31 to 40 mm Hg, but changed proportionally with mean arterial blood pressure values outside this narrow range. Multiple regression analysis showed that mean flow velocity was primarily determined by mean arterial blood pressure. These data suggest that in preterm infants regulation of cerebral blood flow velocity occurs only over a narrow range of mean arterial blood pressure values.
In Vivo Recognition of an RNA Aptamer by Its Transcription Factor Target (2001)

In vitro-selected RNA aptamers are potential inhibitors of disease-related macromolecules. Our laboratory previously isolated an RNA aptamer that specifically binds to the human transcription factor NF-kappaB. This RNA aptamer competitively inhibits DNA binding by NF-kappaB in vitro. In the study presented here, this aptamer was tested for binding to the p50 homodimer form of NF-kappaB (p50(2)) in eukaryotic cells using a yeast three-hybrid system. We show that the alpha-p50 RNA aptamer selectively binds recombinant p50(2) expressed in yeast, demonstrating in vivo recognition of an in vitro-selected RNA aptamer by its protein target. This result suggests that RNA decoys might be used to inhibit the function of DNA-binding proteins in vivo.
Two-dimensional arrays for medical ultrasound using multilayer flexible circuit interconnection (1998)

The development of 2-D array transducers has received much recent interest. Unfortunately, fabrication of high density 2-D arrays is difficult due to the large number of electrical interconnections which must be made to the back side of the elements. A typical array operating at 2.2 MHz may have 256 or more connections within a 16.4 mm circular footprint. Interconnection becomes even more challenging as operating frequencies increase. To solve this problem, we have developed a multilayer flexible (MLF) circuit interconnect consisting of a polyimide dielectric with inter-laminar vias routing signals vertically and etched metal traces routing signals horizontally. A transducer is fabricated from an MLF by bonding a PZT chip to its surface and dicing the chip into individual elements, with the saw kerf extending partially into the top polyimide layer to ensure physical and electrical isolation of the elements. The KLM model was used to compare the performance of an MLF 2-D array to a conventional hand wired 2-D array. MLF and wire guide transducers were fabricated, each with 256 active elements, 0.4 mm interelement spacing, and 2.2 MHz center frequency. Vector impedance, pulse length, bandwidth, angular response, and cross-coupling were found to be comparable in both types of arrays. Using the MLF, however, fabrication time was reduced dramatically. More importantly, MLF technology may be used to increase 2-D array connection density beyond the limitations of current of hand wired fabrication techniques. Thus MLF circuits provide a means for the interconnection of current and future high frequency 2-D arrays.
Tastes ofL-Glutamyl Oligopeptides in Relation to Their Chromatographic Properties (1973)

Twelve L-glutamyl dipeptides were prepared and on the basis of their tastes were classified into three groups: I brothy taste group (Glu-Asp, Glu-Thr, Glu-Ser and Glu-Glu); II flat taste group (Glu-Gly, Glu-Ala, Glu-Pro and Glu-Val); and III bitter taste group (Glu-Ile, Glu-Leu, Glu-Tyr and Glu-Phe). Examination with ion-exchange, thin layer and paper partition chromatographies showed that the dipeptides in I were more acidic, polar and hydrophilic than those in II, the bitter dipeptides (III) being rather hydrophobic. Similar tests for a brothy taste tripeptide, Glu-Gly-Ser, indicated that this possessed properties resembling I. O-Acetylation of the serine residue of Glu-Gly-Ser lessened its hydrophilicity and the taste became flat. The O-butyrylation resulted in a marked increase in hydrophobicity and the product showed a bitter taste.
Distributed execution of aggregated multi domain workflows using an agent framework (2007)

In e-Science, meaningful experiment processes and workflow engines emerge as important scientific resources. A complex experiment often involves services and processes developed in different scientific domains. Aggregating different workflows into one meta workflow avoids unnecessary rewriting of experiment processes and thus improves the reuse efficiency. Remote workflow engines explore the computing power of distributed environment. However, the diversity of workflow description and execution models makes the integration between engines difficult. An agent framework uses ontology based communication language and makes the integration to semantic information of resources seamless, it is thus suitable for coupling distributed engines. In this paper, we present our work in the context of Dutch Virtual Laboratory for e-Science (VL-e) project. A semantic registry for describing workflow engines is implemented, and mobile agents are used to manage distributed workflow coordination.
Formation of the eIF4F Translation–Initiation Complex Determines Sensitivity to Anticancer Drugs Targeting the EGFR and HER2 Receptors (2011)

Elucidating how cancer cells respond to antagonists of HER receptor family members is critical to understanding mechanisms of therapeutic resistance that arise in patients. In large part, resistance to such agents appears to arise from deregulation of the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway. mTOR-dependent phosphorylation of the translation repressor 4E-BP1 leads to its dissociation from eIF4E, thereby causing an increase in the formation of the eIF4F complex, which also comprises eIF4G and eIF4A. In this study, we show that trastuzumab, cetuximab, and erlotinib all decrease the formation of the eIF4F complex in breast, colon, and head and neck cancer cells, respectively. Ectopic expression of eIF4E restores the trastuzumab-dependent defect in eIF4F formation, renders cells resistant to the trastuzumab-mediated decrease in cell proliferation, and rescues breast cancer xenografts from inhibition by trastuzumab. In breast tumor specimens, the level of eIF4E expression is associated with the therapeutic response to a trastuzumab-based regimen. Together, our findings suggest that formation of the eIF4F complex may be a critical determinant of the response to anticancer drugs that target HER2 and epidermal growth factor receptor.
Stem cell antigen‐1+ cell‐based bone morphogenetic protein‐4 gene transfer strategy in mice failed to promote endosteal bone formation (2009)

Sca-1+ cell-based BMP4 ex vivo strategy did not promote robust endosteal bone formation, raising the possibility of intrinsic differences between FGF2- and BMP4-based strategies in their ability to promote endosteal bone formation. It emphasizes the importance of choosing an appropriate bone growth factor gene for delivery by this Sca-1+ cell-based ex vivo systemic gene transfer strategy to promote bone formation.
Strategies for covalent attachment of DNA to beads (2004)

Several covalent attachment chemistries were tested for the immobilization of DNA onto glass beads. The comparison was based on the ability of these chemistries to produce derivatized beads that give good hybridization signals. Cyanuric chloride, isothiocyanate, nitrophenyl chloroformate, and hydrazone chemistries gave us the best (yet comparable) hybridization signals. We further characterized the cyanuric chloride method for the number of attachment sites, number of hybridizable sites, hybridization kinetics, effect of linker length on hybridization intensity and stability of the derivatized beads.
Design and Structure of Stapled Peptides Binding to Estrogen Receptors (2011)

Synthetic peptides that specifically bind nuclear hormone receptors offer an alternative approach to small molecules for the modulation of receptor signaling and subsequent gene expression. Here we describe the design of a series of novel stapled peptides that bind the coactivator peptide site of estrogen receptors. Using a number of biophysical techniques, including crystal structure analysis of receptor-stapled peptide complexes, we describe in detail the molecular interactions and demonstrate that all-hydrocarbon staples modulate molecular recognition events. The findings have implications for the design of stapled peptides in general.
Cerium(IV) Ammonium NitrateA Versatile Single-Electron Oxidant (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCerium(IV) Ammonium NitrateA Versatile Single-Electron OxidantVijay Nair and Ani DeepthiView Author Information Organic Chemistry Section, Regional Research Laboratory (CSIR), Trivandrum, India Cite this: Chem. Rev. 2007, 107, 5, 1862–1891Publication Date (Web):April 14, 2007Publication History Received12 July 2006Published online14 April 2007Published inissue 1 May 2007https://pubs.acs.org/doi/10.1021/cr068408nhttps://doi.org/10.1021/cr068408nresearch-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views14115Altmetric-Citations357LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Cations,Ethers,Hydrocarbons,Oxidation Get e-Alerts
Homography-based planar mapping and tracking for mobile phones (2011)

We present a real-time camera pose tracking and mapping system which uses the assumption of a planar scene to implement a highly efficient mapping algorithm. Our light-weight mapping approach is based on keyframes and plane-induced homographies between them. We solve the planar reconstruction problem of estimating the keyframe poses with an efficient image rectification algorithm. Camera pose tracking uses continuously extended and refined planar point maps and delivers robustly estimated 6DOF poses. We compare system and method with bundle adjustment and monocular SLAM on synthetic and indoor image sequences. We demonstrate large savings in computational effort compared to the monocular SLAM system while the reduction in accuracy remains acceptable.
Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones. (1993)

alpha-Crystallin, composed of the subunits alpha A and alpha B, is a major vertebrate eye lens protein, accomplishing a structural role in maintaining lens stability and transparency. Both subunits also occur in low amounts outside the lens, where their precise function is unknown. They are structurally related to the small heat-shock proteins (HSPs), and increasing evidence indicates that they have also functional similarities with the small HSPs. To extend our insight into these structural and functional relationships, the mouse small HSP (HSP25) was compared with bovine alpha-crystallin, with respect to several known properties of the latter. We show that alpha-crystallin and HSP25 resemble each other in secondary structure and have similar stability toward urea dissociation at pH 7.0. Mixed polymers can be formed from any combination of alpha A-crystallin, alpha B-crystallin, and HSP25 subunits. Furthermore, we demonstrate that HSP25, like alpha-crystallin, can function as a molecular chaperone, by suppressing heat-induced aggregation of other proteins, and is an efficient inhibitor of elastase. Finally, HSP25 is found to be a substrate for protein cross-linking by tissue-type transglutaminase, like alpha B-crystallin. Our results thus corroborate that alpha-crystallin and the small HSPs have comparable functions, probably being involved in the protection of other proteins under conditions of stress.