gebhart/patrepeval huggingface dataset:
Validity maintenance of semantic feature models (1999)

Article Validity maintenance of semantic feature models Share on Authors: Rafael Bidarra Faculty of Information Technology and Systems, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delhi, The Netherlands Faculty of Information Technology and Systems, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delhi, The NetherlandsView Profile , Willem F. Bronsvoort Faculty of Information Technology and Systems, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delhi, The Netherlands Faculty of Information Technology and Systems, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delhi, The NetherlandsView Profile Authors Info & Claims SMA '99: Proceedings of the fifth ACM symposium on Solid modeling and applicationsJune 1999 Pages 85–96https://doi.org/10.1145/304012.304021Online:01 June 1999Publication History 13citation296DownloadsMetricsTotal Citations13Total Downloads296Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Mechanistic Study on the Replacement Reaction between Silver Nanostructures and Chloroauric Acid in Aqueous Medium (2004)

The replacement reaction between silver nanostructures and an aqueous HAuCl(4) solution has recently been demonstrated as a versatile method for generating metal nanostructures with hollow interiors. Here we describe the results of a systematic study detailing the morphological, structural, compositional, and spectral changes involved in such a heterogeneous reaction on the nanoscale. Two distinctive steps have been resolved through a combination of microscopic and spectroscopic methods. In the first step, silver nanostructure (i.e., the template) is dissolved to generate gold atoms that are deposited epitaxially on the surface of each template. Silver atoms also diffuse into the gold shell (or sheath) to form a seamless, hollow nanostructure with its wall made of Au-Ag alloys. The second step involves dealloying, a process that selectively removes silver atoms from the alloyed wall, induces morphological reconstruction, and finally leads to the formation of pinholes in the walls. Reaction temperature was found to play an important role in the replacement reaction because the solubility constant of AgCl and the diffusion coefficients of Ag and Au atoms were both strongly dependent on this parameter. This work has enabled us to prepare metal nanostructures with controllable geometric shapes and structures, and thus optical properties (for example, the surface plasmon resonance peaks could be readily shifted from 500 to 1200 nm by controlling the ratio between Ag and HAuCl(4)).
Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T‐cells (2007)

We developed a functional chimeric TCR against PSCA for treatment of PCa. The chimeric alpha-PSCA-beta2/CD3zeta-TCR might now be used for arming human cytotoxic T-cells for further studies towards a clinical treatment of PCa.
Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. (1989)

Gene amplification in human tumor cells is frequently mediated by extrachromosomal elements (e.g., double minute chromosomes [DMs]). Recent experiments have shown that DMs can be formed from smaller, submicroscopic circular precursors referred to as episomes (S. M. Carroll, M. L. DeRose, P. Gaudray, C. M. Moore, D. R. Needham-Vandevanter, D. D. Von Hoff and G. M. Wahl, Mol. Biol. 8:1525-1533, 1988). To investigate whether episomes are generally involved as intermediates in gene amplification, we determined whether they mediate the amplification of the mdr1 gene, which when overexpressed engenders cross resistance to multiple lipophilic drugs. A variety of methods including electrophoresis of undigested DNAs in high-voltage gradients, NotI digestion, and production of double-strand breaks by gamma irradiation were used to distinguish between mdr1 sequences amplified on submicroscopic circular molecules and those amplified within DMs or chromosomal DNA. The gamma-irradiation procedure provides a new method for detecting and determining the size of circular molecules from 50 kilobases (kb) to greater than 1,000 kb. These methods revealed that some of the amplified mdr1 genes in vinblastine-resistant KB-V1 cells are contained in supercoiled circular molecules of approximately 600 and approximately 750 kb. Analysis of the replication of these molecules by a Meselson-Stahl density shift experiment demonstrated that they replicate approximately once in a cell cycle. The data lend further support to a model for gene amplification in which DMs are generally formed from smaller, autonomously replicating precursors.
Growth of ordered, single-domain, alumina nanopore arrays with holographically patterned aluminum films (2002)

Highly-ordered, single-domain (∼cm2), alumina nanopore arrays with controlled symmetry were obtained by anodizing prepatterned aluminum films that were deposited on silica substrates. Holographic lithography, in conjunction with a conformal deposition process, was utilized to form nanoscale corrugations on aluminum film surface prior to anodization. Both the order and symmetry of pore arrays were found to be well controlled and guided by the periodic surface corrugations from the initial stage of pore growth. Ordered nanopore arrays grown on foreign substrates are promising as a host or template for forming various nanodevices and their on-chip integration.
Nasal potential difference: a clinical diagnostic test for cystic fibrosis (1990)

Patients with cystic fibrosis (CF) demonstrate a markedly more negative potential difference (PD) across respiratory epithelia than normal or "diseased" controls. A technique is described for the measurement of nasal PD in both children and adults. 145 non-CF subjects showed a mean PD of -19.0 mV (range -2 to -36) in comparison to 60 patients with cystic fibrosis with mean of -46.0 mV (range -32 to -77). Amongst the latter group those with more severe disease had a more negative PD. Measurement of nasal PD is easily learnt and rapidly performed and may provide an additional means of diagnosis for CF.
Bifunctional PEGylated Exenatide-Amylinomimetic Hybrids to Treat Metabolic Disorders: An Example of Long-Acting Dual Hormonal Therapeutics (2013)

Peptide hybrids (phybrids) comprising covalently linked peptide hormones can leverage independent biological pathways for additive or synergistic metabolic benefits. PEGylation of biologics offers enhanced stability, duration, and reduced immunogenicity. These two modalities can be combined to produce long-acting therapeutics with dual pharmacology and enhanced efficacy. Compound 10 is composed of an exenatide (AC2993) analogue, AC3174, and an amylinomimetic, davalintide (AC2307), with an intervening 40 kD PEG moiety. It displayed dose-dependent and prolonged efficacy for glucose control and body weight reduction in rodents with superior in vitro and in vivo activities compared to those of a side-chain PEGylated phybrid 6. In diet-induced obese (DIO) rats, the weight-loss efficacy of 10 was similar to that of a combination of PEG-parents 3 and 4. A single dose of 10 elicited sustained body weight reduction in DIO rats for at least 21 days. Compound 10's terminal half-life of ~27 h should translate favorably to weekly dosing in humans.
Direct classification of all American English phonemes using signals from functional speech motor cortex (2014)

We identified specific spatiotemporal features that aid classification, which could guide future applications. Word identification was equivalent to information transfer rates as high as 3.0 bits s(-1) (33.6 words min(-1)), supporting pursuit of speech articulation for BCI control.
Separation of alcohol-water mixtures using salts (1982)

Use of a salt (KF or Na/sub 2/SO/sub 4/) to induce phase separation of alcohol-water mixtures was investigated in three process flowsheets to compare operating and capital costs with a conventional distillation process. The process feed was the Clostridia fermentation product, composed of 98 wt % water and 2 wt % solvents (70% 1-butanol, 27% 2-propanol, and 3% ethanol). The design basis was 150 x 10/sup 6/ kg/y of solvents. Phase equilibria and tieline data were obtained from literature and experiments. Three separation-process designs were developed and compared by an incremental economic analysis (+-30%) with the conventional separation technique using distillation alone. The cost of salt recovery for recycle was found to be the critical feature. High capital and operating costs make recovery of salt by precipitation uneconomical; however, a separation scheme using multiple-effect evaporation for salt recovery has comparable incremental capital costs ($1.72 x 10/sup 6/ vs $1.76 x 10/sup 6/) and lower incremental operating costs ($2.14 x 10/sup 6//y vs $4.83 x 10/sup 6//y) than the conventional separation process.
Undernutrition in the elderly population living at home in the community: a review of the literature (1997)

Undernourishment in elderly people has been found to have a variety of detrimental effects ranging from the development of pressure sores to the incidence of fractured femurs. Surveys within hospital settings have revealed that elderly patients are often admitted from their homes in a state of malnutrition, which would indicate nutritional deficits in at least some of the population. Reliable nutritional assessment in the community, however, is difficult and time consuming, with findings subject to distortions from other influences. Consequently there is inadequate accurate assessment of the current nutritional status of the general elderly population, and assumptions are often based on research findings from the 1960s and 1970s. In view of the demographic changes which have moved towards an increasingly 'old' elderly population such research may no longer be relevant. This paper provides a review of the available literature on nutrition in elderly people living at home and includes possible assessment screening strategies that could be used by community nurses.
Prevention and Cure of Digestive Disorders Through the Use of Medicinal Plants (2007)

Medicinal plants have proved to be effective for prevention and cure of various disorders. Their use against digestive disorders is very common at household level. The future generations can benefit, in case this knowledge is documented after its validation. Participatory Rural Appraisal (PRA) methods and tools were used for interacting with the rural women who were used as the main source of information. Scientific validation helped to determine the pharmacognosy and pharmacology status of the plants. The sources used for scientific validation were mainly the view of the experts and scientific literature besides adding the social value considering the views of Hakims and Vaidyas. The identification validation and documentation of the plant material from the state of Punjab reveal that twenty eight plants were used for digestive disorders and most of them were herbs. They were used for their preventive and curative properties. Most of these plants were available in the vicinity or their parts were available in form of spices at the household level.
Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways (2003)

AF-promoting atrial structural remodeling in experimental CHF involves angiotensin II-dependent and angiotensin II-independent pathways. Significant apoptosis occurs, but prevention of apoptosis by ACE inhibition only partially prevents atrial structural remodeling.
High-speed rewritable DVD up to 20 m/s with nucleation-free eutectic phase-change material of Ge(Sb 70 Te 30 )+Sb (2000)

High speed overwriting capability of the nucleation-free and growth-dominant eutectic Ge(Sb<SUB>70</SUB>Te<SUB>30</SUB>)+Sb phase- change material, and its application to high speed overwritable DVD and CD, are discussed. The addition of Ge to Sb<SUB>70</SUB>Te<SUB>30</SUB>+Sb binary system could effectively suppress the nucleation in recrystallization process, while high Sb/Te ratio could realize a selective enhancement of crystalline growth-speed initiated from the boundary of an amorphous mark and its crystalline background. This resolved a trade-off in high speed erasure and archival stability of amorphous marks. Highly enhanced crystalline growth also caused serious recrystallization during amorphous mark formation, resulting in shrinkage of amorphous mark size (premature cooling issue). This premature cooling issue as well as premature heating issue, in multiple pulse strategy with such a short writing and cooling pulse as below 10 nsec at high clock frequency of > 100 MHz for over 4X speed rewritable DVD, were resolved with a 2T-period based multiple pulse strategy. Thus, feasibility of 2 - 4.8X CAV operatable rewritable DVD and 16X CD-RW was demonstrated.
21.5 dBm power-handling 5 GHz transmit/receive CMOS switch realized by voltage division effect of stacked transistor configuration with Depletion-layer-Extended Transistors (DETs) (2003)

This paper reports for the first time an over-20 dBm power-handling 5 GHz transmit/receive (T/R) CMOS switch. The Depletion-layer-Extended Transistor (DET), which possesses high effective substrate resistance, enables the voltage division effect of the stacked transistor configuration to work in CMOS, thus realizing this high power-handling capability. Furthermore, despite insertion-loss (I/sub L/) degradation due to double on-resistance with the stacked transistor configuration, a receive-mode I/sub L/ (I/sub L/@RX) of as low as 1.44 dB at 5 GHz is accomplished with the benefit of the I/sub L/ improvement effects in the DET, in addition to a very low transmit-mode I/sub L/ (I/sub L/@TX) of 0.95 dB at 5 GHz.
Coulomb blockade electrometer with a high-T c island (1996)

We report on a successful attempt to fabricate a Coulomb blockade electrometer consisting of an ultrasmall YBa2Cu3O7−δ (YBCO) island coupled to two gold electrodes through a high-resistance native surface tunnel barrier. A third electrode placed near the island was used as an electrostatic gate. Spectra typical for tunneling into the YBCO superconductor were reproducibly measured. At temperatures below 0.5 K the low-bias conductance was suppressed by the Coulomb blockade. The blockade could be periodically varied by the gate potential. An external magnetic field of up to 5 T strongly influenced the transport via the island but without any change in the period of the Coulomb oscillations.
Laboratory Evaluation of Biologically-Based Compounds as Antifeedants for the Pales Weevil, Hylobius pales (Herbst) (Coleoptera: Curculionidae) (1994)

Twenty plant-produced compounds or mixtures and one insect-produced semiochemical were evaluated as potential antifeedants for the pales weevil, Hylobius pales (Herbst). Initially, a choice laboratory feeding bioassay was conducted to screen the compounds and identify antifeedant activity. This was followed by a no-choice dose-response bioassay to further evaluate the most active compounds from the choice test. In the choice test, nine compounds inhibited feeding by H. pales on white pine, Pinus strobus L., twigs after 24 h: borneol, bornyl acetate, cucurbitacin, limonin, myrcene, neem extract, S (+) and R (−) carvone, and verbenone. Five of these compounds remained active after 48 h: borneol, limonin, neem extract, and both carvone isomers. In the no-choice test, 10% concentrations of S (+) carvone and limonin were the most active compounds for both males and females after 24 h. Borneol, verbenone, and R (−) carvone were active for males only. After 48 h, limonin and S (+) carvone remained most active compounds for males, with cucurbitacin and verbenone also showing activity. However, only limonin was active for females. Dose responses (0.1–10% concentrations) were strong for limonin and both carvone isomers. Cucurbitacin, diluted from a 0.3% concentrate, exhibited similar responses at all three doses, indicating that a more concentrated formulation may have potential as an antifeedant for H. pales. Limonin, both carvone isomers, and verbenone also show promise and will be further evaluated in future studies.
Valuing Health-Related Quality of Life in Diabetes (2002)

Major diabetes complications are associated with worse health-related quality of life. The health utility scores provided should facilitate studies of the health burden of diabetes and the cost-utility of alternative strategies for the prevention and treatment of diabetes.
RTP Payload Format for MPEG-4 Audio/Visual Streams (2000)

This document describes Real-Time Transport Protocol (RTP) payload formats for carrying each of MPEG-4 Audio and MPEG-4 Visual bitstreams without using MPEG-4 Systems. For the purpose of directly mapping MPEG-4 Audio/Visual bitstreams onto RTP packets, it provides specifications for the use of RTP header fields and also specifies fragmentation rules. It also provides specifications for Multipurpose Internet Mail Extensions (MIME) type registrations and the use of Session Description Protocol (SDP).
Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells (2000)

It has long been known that N-acylethanolamine phospholipids [N-acylphosphatidylethanolamine (N-acyl PE)] and N-acylethanolamines (NAEs) accumulate in mammalian tissues undergoing degenerative membrane changes associated with necrosis. Here we studied the effects of stress factors (UVB irradiation and serum deprivation) on the endogenous levels of N-acyl PE and NAE in mouse epidermal JB6 P(+) cells. We found that 16:0, 18:0, 18:1,n-9 and 18:1,n-7 are the predominant amide-linked fatty acids in both N-acyl PE and NAE in these cells. UVB irradiation and serum deprivation resulted in significantly increased levels of N-acyl PE and NAE, especially 18:1, n-9 N-acyl PE and NAE. UVB challenge increased the cellular content of anandamide (20:4,n-6 NAE), but this increase was the lowest of all NAEs measured. Serum deprivation resulted in a decreased cellular anandamide level, as well as a decrease in 20:4,n-6 N-acyl PE. Interestingly, the replacement of serum-free medium with medium containing 5% (v/v) fetal calf serum after 36 h of serum deprivation restored N-acyl PE and NAE levels almost completely within 4-8 h. These data suggest the involvement of N-acyl PE and NAE in cellular responses to stress.
The computational processing of intonational prominence: a functional prosody perspective (1997)

Intonational prominence, or accent, is a fundamental prosodic feature that is said to contribute to discourse meaning. This thesis outlines a new, computational theory of the discourse interpretation of prominence, from a FUNCTIONAL PROSODY perspective. Functional prosody makes the following two important assumptions: first, there is an aspect of prominence interpretation that centrally concerns discourse processes, namely the discourse focusing nature of prominence; and second, the role of prominence in language processing in general, and discourse processing in particular, is not essentially separate from the processing of other grammatical, nonprosodic information. This thesis develops a computational theory of prominence interpretation by explaining how prominence serves as an inference cue in discourse processing. Prominence signals changes in the attentional status of entities in a discourse model, while nonprominence signals that the realized entities are already in discourse focus. Evidence for the new theory is provided by distributional analysis of a spontaneous narrative monologue. New discourse processing algorithms that integrate form of expression, grammatical function and intonational prominence information for reference resolution and attentional state modeling show how the principles of the theory may be applied in SPEECH UNDERSTANDING systems. Finally, aspects of the new theory are explored in accent prediction experiments on a corpus of spontaneous and read direction-giving monologues. Machine learning is used to investigate the extent to which the analyzed higher-level linguistic features associated with prominence may combine with lower-level features that are known to influence accent assignment. Original constituent-based accent prediction experiments attempt to bootstrap off of established knowledge about citation-form accenting, and begin to develop an understanding of how the examined features of discourse context may be integrated into accent assignment systems for text-to-speech synthesis.
Oral Treatment with Probiotics Reduces Allergic Symptoms in Ovalbumin-Sensitized Mice: A Bacterial Strain Comparative Study (2009)

B. breve M-16V was identified as the most potent antiallergic strain.
Assembly of TolC, a Structurally Unique and Multifunctional Outer Membrane Protein of Escherichia coli K-12 (2003)

TolC is a multifunctional outer membrane protein of Escherichia coli that folds into a novel alpha-beta-barrel conformation absent in the other model outer membrane proteins used in assembly studies. The data presented in this work show that the unique folded structure of TolC reflects a unique assembly pathway. During its assembly, the newly translocated nascent TolC monomers are released in the periplasm. Maturation of these nascent monomers, and possibly their oligomerization, in the periplasm precedes their insertion in the outer membrane. The completion of the assembly process is signaled by the development of a characteristic proteinase K-resistant fragment generated by cleavage at a single, periplasmically exposed, protease-sensitive site of the membrane-anchored trimer. None of the assembly steps of TolC is affected by known folding factors, such as SurA, Skp, and lipopolysaccharide, which have profound effects on the assembly of other model trimeric outer membrane proteins. Two assembly-defective TolC mutants were isolated and characterized. One of the mutants (TolC(I106N)) was defective in the folding of nascent monomers, while the other (TolC(S350F)) was impaired in steps involving trimerization and membrane insertion of folded monomers.
Cancer Stem Cells (2011)

The concept of cancer stem cells has generated significant interests among cancer researchers. This has led to proliferative number of publications on the subject in the recent years and eventually controversies because of conflicting data in the literature. As we try to find relevance of the stem cell concept to various aspects of cancer biology, we also discover individual differences that drive the cancer stemness. Nevertheless, the concept of cancer stem cell is likely to stay and is already making huge impact as we develop novel diagnostics and therapeutics for cancer.

In this special issue, we selected reviews on the unique stem cell biology in breast cancer, head and neck cancer, lung cancer, and brain malignancy and touched the topic of therapeutic resistance as a consequence of cancer stem cells. Individual research papers were also selected to demonstrate the relevance of cancer stem cells to cancer metastasis and apoptosis.

As we embrace the concept of cancer stem cells, it is important to realize its limitations. We have learnt that antiangiogenic drugs that attack tumor blood vessels, an important aspect of cancer biology, have not been able to cure cancer and may cause unique side effects in patients. By the same token, toxicities are of concern when the stem cells of normal tissues are injured by agents that target stem cell pathways. With this issue, we aim to provoke discussion and awareness of cancer stem cell biology, as some of research findings are being translated and making their way to our oncology practice.


Bo Lu

Shih-Hwa Chiou

Eric Deutsch

Aurelio Lorico