gebhart/patrepeval huggingface dataset:
Coping with Variable Latency and Disorder in Distributed Event Streams (2006)

Distributed event processing systems often require input streams that are ordered in some predetermined way or that events arrive within a fixed time interval. This order may simply be arrival order or given explicitly on a specific event attribute, such as a timestamp or sequence number. Standing event queries, such as a temporal correlation of events across multiple streams, can block if an input stream incurs latency or may produce an incorrect answer if events fail to arrive within the fixed time interval. In this paper, we describe a stream conditioning mechanism developed for Event Correlation Services (ECS), which is a high performance event processing service for monitoring distributed applications. We show how punctuation messages that carry timestamps can be generated by event sources and then forwarded through the network, to align events from multiple distributed streams and unblock event pattern queries.
Efficacy of the ‘tennis ball technique’ versus nCPAP in the management of position‐dependent obstructive sleep apnoea syndrome (2008)

Control of body position during sleep using an anti-supine device mimicking the so-called 'tennis ball technique' provides benefit in the management of position-dependent OSAHS in subjects who meet strict inclusion criteria. The overall improvement is, however, less than for nCPAP.
Synthesis and Biological Activity of Human Neuropeptide S Analogues Modified in Position 2 (2008)

Neuropeptide S (NPS) has been identified as the endogenous ligand of a previously orphan receptor now named NPSR. Previous studies demonstrated that the N-terminal sequence Phe (2)-Arg(3)-Asn(4) of the peptide is crucial for biological activity. Here we report on a focused structure-activity study of Phe(2) which has been replaced with a series of coded and noncoded amino acids. Thirty-one human NPS analogues were synthesized and pharmacologically tested for intracellular calcium mobilization by using HEK293 cells stably expressing the mouse NPSR. The results of this study demonstrated the following NPS position 2 structure-activity features: (i) lipophilicity but not aromaticity is crucial, (ii) both the size of the chemical moiety and its distance from the peptide backbone are important for biological activity, and (iii) this position plays a role in both receptor binding and activation, since [4,4'-biphenyl-Ala(2)]hNPS behaved as a partial agonist.
Hot-electron immunity of SiO/sub 2/ dielectrics with fluorine incorporation (1989)

The effect of fluorine incorporation in the gate oxide on the NMOSFET hot-electron immunity is examined. Fluorine is implanted in the polysilicon gate and diffused into the gate oxide. The hot-electron immunity of NMOSFETs is shown to increase with increasing fluorine doses. Measurement of device lifetime against substrate current shows that higher doses of fluorine lead to a change in the immunity to interface trap generation. Based on the results of Auger measurements, this has been correlated with a fluorine deficient layer near the interface. >
Proteomic Analysis of Human Serum by Two-Dimensional Differential Gel Electrophoresis after Depletion of High-Abundant Proteins (2004)

Two-dimensional differential gel electrophoresis (2-D DIGE) was used to analyze human serum following the removal of albumin and five other high-abundant serum proteins. After protein removal, serum was analyzed by SDS-PAGE as a preliminary screen, and significant differences between four high-abundant protein removal methods were observed. Antibody-based albumin removal and high-abundant protein removal methods were found to be efficient and specific. To further characterize serum after protein removal, 2-D DIGE was employed, enabling multiplexed analysis of serum through the use of three fluorescent protein dyes. Comparison between crude serum and serum after removal of high-abundant proteins clearly illustrates an increase in the number of lower abundant protein spots observed. Approximately 850 protein spots were detected in crude serum whereas over 1500 protein spots were exposed following removal of six high-abundant proteins, representing a 76% increase in protein spot detection. Several proteins that showed a 2-fold increase in intensity after depletion of high-abundant proteins, as well as proteins that were depleted during abundant protein removal methods, were further characterized by mass spectrometry. This series of experiments demonstrates that high-abundant protein removal, combined with 2-D DIGE, is a practical approach for enriching and characterizing lower abundant proteins in human serum. Consequently, this methodology offers advances in proteomic characterization, and therefore, in the identification of biomarkers from human serum.
A complete fault diagnostic system for automated vehicles operating in a platoon (2001)

A "complete" fault diagnostic system is developed for automated vehicles operating as a platoon on an automated highway system. The diagnostic system is designed to monitor the complete set of sensors and actuators used by the lateral and longitudinal controllers of the vehicle, including radar sensors, magnetometers and inter-vehicle communication systems. A fault in any of the twelve sensors and three actuators is identified without requiring any additional hardware redundancy. The diagnostic system uses parity equations and several reduced-order nonlinear observers constructed from a simplified dynamic model of the vehicle. Nonlinear observer design techniques are used to guarantee asymptotically stable convergence of estimates for the nonlinear dynamic system. Different combinations of the observer estimates and the available sensor measurements are then processed to construct a bank of residues. The paper analytically shows that a fault in any one of the sensors or actuators creates a unique subset of these residues to grow so as to enable exact identification of the faulty component. Both simulation and experimental results are presented to demonstrate the effectiveness of the fault diagnostic system in the presence of various faults.
Identification of an atypical lipoprotein‐binding protein from human aortic smooth muscle as T‐cadherin (1998)

We have previously described an atypical lipoprotein-binding protein of about 105 kDa (p105) in membranes of vascular smooth muscle cells (VSMCs) that is distinct from currently known lipoprotein receptors. In the present work we have developed a procedure for purification of p105 from human aortic media. Partial sequencing of purified protein has revealed identity of p105 with human T-cadherin. Anti-peptide antisera raised against human T-cadherin recognized a protein spot corresponding to the purified p105 on two-dimensional Western blots. The antisera also inhibited LDL binding to p105 on ligand blots. We conclude that the 105 kDa lipoprotein-binding protein present in human VSMCs is T-cadherin, an unusual glycosylphosphatidylinositol-anchored member of the cadherin family of cell-cell adhesion proteins.
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo (2001)

We present evidence that some low-grade oligodendrogliomas may be comprised of proliferating glial progenitor cells that are blocked in their ability to differentiate, whereas malignant gliomas have additionally acquired other mutations such as disruption of cell cycle arrest pathways by loss of Ink4a-Arf. We have modeled these effects in cell culture and in mice by generating autocrine stimulation of glia through the platelet-derived growth factor receptor (PDGFR). In cell culture, PDGF signaling induces proliferation of glial precursors and blocks their differentiation into oligodendrocytes and astrocytes. In addition, coexpression of PDGF and PDGF receptors has been demonstrated in human gliomas, implying that autocrine stimulation may be involved in glioma formation. In this study, using somatic cell type-specific gene transfer we investigated the functions of PDGF autocrine signaling in gliomagenesis by transferring the overexpression of PDGF-B into either nestin-expressing neural progenitors or glial fibrillary acidic protein (GFAP)-expressing astrocytes both in cell culture and in vivo. In cultured astrocytes, overexpression of PDGF-B caused significant increase in proliferation rate of both astrocytes and neural progenitors. Furthermore, PDGF gene transfer converted cultured astrocytes into cells with morphologic and gene expression characteristics of glial precursors. In vivo, gene transfer of PDGF to neural progenitors induced the formation of oligodendrogliomas in about 60% of mice by 12 wk of age; PDGF transfer to astrocytes induced the formation of either oligodendrogliomas or mixed oligoastrocytomas in about 40% of mice in the same time period. Loss of Ink4a-Arf, a mutation frequently found in high-grade human gliomas, resulted in shortened latency and enhanced malignancy of gliomas. The highest percentage of PDGF-induced malignant gliomas arose from of Ink4a-Arf null progenitor cells. These data suggest that chronic autocrine PDGF signaling can promote a proliferating population of glial precursors and is potentially sufficient to induce gliomagenesis. Loss of Ink4a-Arf is not required for PDGF-induced glioma formation but promotes tumor progression toward a more malignant phenotype.
TNF-α Sensitizes HT-29 Colonic Epithelial Cells to Intestinal Lactobacilli1 (2002)

The ability of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) to influence epithelial interleukin (IL)-8 responses to the intestinal bacterium Lactobacillus plantarum 299v was analyzed in the human HT-29 colonic epithelial cell line. In the absence of TNF-alpha, IL-8 mRNA expression was not detectable by Northern blot analysis in HT-29 cells alone or in HT-29 cells co-cultured with L. plantarum 299v. However, TNF-alpha induced IL-8 mRNA expression, and co-culture of TNF-alpha-treated HT-29 cells with L. plantarum 299v significantly increased IL-8 mRNA expression above levels induced by TNF-alpha alone in an adhesion-dependent manner. The increase in IL-8 mRNA expression was not observed in TNF-alpha-treated HT-29/L. plantarum 299v co-cultures using heat-killed lactobacilli or when L. plantarum adhesion was prevented using mannoside or a trans-well membrane. Paradoxically, IL-8 secretion was decreased in TNF-alpha-treated HT-29 cells with L. plantarum 299v relative to cells treated with TNF-alpha alone. TNF-alpha-mediated responsiveness to L. plantarum 299v was further investigated by analyzing expression of a coreceptor for bacterial cell wall products CD14. HT-29 cells expressed CD14 mRNA and cell-surface CD14; however, TNF-alpha did not alter CD14 mRNA or cell-surface expression, and blockade of CD14 with monoclonal antibody MY4 did not alter the IL-8 response to L. plantarum 299v in TNF-alpha-treated HT-29 cells. These results indicate that although TNF-alpha sensitizes HT-29 epithelial cells to intestinal lactobacilli, the bacteria exert a protective effect by downregulating IL-8 secretion.
Spread of porcine circovirus associated disease (PCVAD) in Ontario (Canada) swine herds: Part I. Exploratory spatial analysis (2010)

In Ontario, PCVAD has shown a general trend, spreading from east-to-west. We interpret the existence of spatio-temporal clustering as evidence of spatio-temporal aggregation of PCVAD-positive cases above expectations and, together with the existence of spatio-temporal and spatial clusters, as suggestive of apparent local spread of PCVAD. Clustering was detected at small spatial and temporal scales. Other patterns of spread could not be detected; however, survival rates in discrete Ontario zones, as well as a lack of a clear spatial pattern in the most likely spatio-temporal clusters, suggest other between-herd transmission mechanisms.
Lysinonorleucine cross‐link formation in alpha amino heptenoic acid‐substituted peptide derivatives (1978)

Abstract Studies on the cross‐linking of a tripeptide ( t ‐butyloxycarbonyl‐ L ‐alanyl‐ D , L ‐2‐amino‐6‐heptenoyl‐ L ‐alanine methyl ester) have shown that it is possible to form specific cross‐links in good yields through Schiff base formation of the ε amino group of lysine. The heptenoic acid residue has been ozonized to an aldehyde and condensed with the ε amino of lysine in the compounds alpha‐ t ‐butyloxycarbonyl‐ L ‐alanyl‐ L ‐lysine methyl ester and alpha‐ t ‐butyloxycarbonyl‐ L ‐lysine methyl ester to form the cross‐link, lysinonorleucine. This compound has been stabilized by reduction with sodium borohydride and quantitated on the amino acid analyzer. This technique converts from 60 to 98% of the available aldehyde to lysinonorleucine.
CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma (2010)

This study shows that a rapid and simplified method can be used to reliably generate CD8+ enriched young TIL for administration as an individualized therapy for advanced melanoma, and may allow this potentially effective treatment to be applied at other institutions and to reach additional patients.
Underpotentially Deposited Metal Layers of Silver Provide Enhanced Stability to Self-Assembled Alkanethiol Monolayers on Gold (1996)

This letter details a straightforward electrochemical method for increasing the thermal stability of alkanethiol-based self-assembled monolayers (SAMs) on polycrystalline gold surfaces. Ex situ ellipsometry and X-ray photoelectron spectroscopy were used to follow the desorption of SAMs into a heated hydrocarbon solvent over the temperature range 70−105 °C. Alkanethiol-based SAMs on gold surfaces modified by underpotential deposition to contain a one-atom-thick interlayer of silver exhibited greater stabilities toward desorption than did SAMs on native gold surfaces. The underpotentially deposited silver layer in this system acts to increase the level of interaction at the gold/sulfur interface. The described method should be compatible with the wide range of alkanethiols that have been adsorbed onto gold surfaces and should provide related levels of improved stability.
Hepatosplenic Yeast Infection in Patients with Acute Leukemia: A Diagnostic Problem (1994)

The occurrence of hepatosplenic candidiasis following prolonged neutropenic periods has emerged as a major problem for patients with leukemia. In order to evaluate the diagnostic value of various available procedures, we analyzed our findings regarding 26 leukemic patients with hepatosplenic candidiasis. A significantly increased level (> 50 mg/L) of serum C-reactive protein (S-CRP) was significantly more common than a daily fever (for which the mean temperature peak was > 37.5 degrees C) or raised levels of liver enzymes (serum alanine transferase, aspartate transferase, or alkaline phosphatase). Focal changes in the liver, spleen, or kidneys were detected in > 90% of the patients examined by computed tomography (CT) but in < 50% of those examined by ultrasonography. Seventeen diagnoses were based on the findings from microscopy of samples obtained invasively, whereas a positive fungal culture was the basis of the diagnosis for only five patients. In conclusion, monitoring the S-CRP level after a patient's recovery from neutropenia is useful in that its elevation is cause for early suspicion of hepatosplenic candidiasis. In detection of the hepatosplenic foci, CT is superior to ultrasonography. For establishing the specific diagnosis, aggressive collection of samples for microscopy is essential.
Antimicrobial Activities of Ceragenins against Clinical Isolates of Resistant Staphylococcus aureus (2007)

The rise in the rates of glycopeptide resistance among Staphylococcus aureus isolates is concerning and underscores the need for the development of novel potent compounds. Ceragenins CSA-8 and CSA-13, cationic steroid molecules that mimic endogenous antimicrobial peptides, have previously been demonstrated to possess broad-spectrum activities against multidrug-resistant bacteria. We examined the activities of CSA-8 and CSA-13 against clinical isolates of vancomycin-intermediate S. aureus (VISA), heterogeneous vancomycin-intermediate S. aureus (hVISA), as well as vancomycin-resistant S. aureus (VRSA) and compared them to those of daptomycin, linezolid, and vancomycin by susceptibility testing and killing curve analysis. We also examined CSA-13 for its concentration-dependent activity, inoculum effect, postantibiotic effect (PAE), and synergy in combination with various antimicrobials. Overall, the MICs and minimal bactericidal concentrations of CSA-13 were fourfold lower than those of CSA-8. Time-kill curve analysis of the VRSA, VISA, and hVISA clinical isolates demonstrated concentration-dependent bactericidal killing. An inoculum effect was also observed when a higher starting bacterial density was used, with the time required to achieve 99.9% killing reaching 1 h with a 6-log10-CFU/ml starting inoculum, whereas it was>or=24 h with a 8- to 9-log10-CFU/ml starting inoculum with 10x the MIC (P<or=0.001). A concentration-dependent PAE was demonstrated with CSA-13, nearly doubling from 2x to 4x the MIC (P=0.03). With respect to the CSA-13 antimicrobial combinations, time-kill curve analysis showed no difference in the log10 CFU/ml at 24 h for the majority of the organisms tested. However, early synergy at 4 to 8 h was detected against the VRSA Pennsylvania strain (2002) when CSA-13 was tested in combination with gentamicin, while early additivity was demonstrated against all of the other organisms.
AN ANTIMALARIAL ALKALOID FROM HYDRANGEA. VIII. ATTEMPTED SYNTHESIS OF 3-[β-KETO-γ-(4-HYDROXY-2-PIPERIDYL)PROPYL]-4-QUINAZOLONE BY THE DIKETONE APPROACH (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAN ANTIMALARIAL ALKALOID FROM HYDRANGEA. VIII. ATTEMPTED SYNTHESIS OF 3-[β-KETO-γ-(4-HYDROXY-2-PIPERIDYL)PROPYL]-4-QUINAZOLONE BY THE DIKETONE APPROACHB. R. BAKER, ROBERT E. SCHAUB, MERLE V. QUERRY, and JAMES H. WILLIAMSCite this: J. Org. Chem. 1952, 17, 1, 77–96Publication Date (Print):January 1, 1952Publication History Published online1 May 2002Published inissue 1 January 1952https://pubs.acs.org/doi/10.1021/jo01135a009https://doi.org/10.1021/jo01135a009research-articleACS PublicationsRequest reuse permissionsArticle Views647Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An RGD–Oligolysine Peptide: A Prototype Construct for Integrin-Mediated Gene Delivery (1998)

We have synthesized a linear, bifunctional peptide that comprises an integrin-targeting domain containing an arginine-glycine-aspartic acid tripeptide motif and a DNA-binding moiety consisting of a short stretch of 16 lysine residues. This peptide can form distinctive, condensed complexes with DNA and is capable of mediating its delivery and expression in a variety of mammalian cells in culture. Internalization is mediated by cell surface integrin receptors via a mechanism that is known to be phagocytic. We have analyzed the relationship between DNA and peptide and have investigated the conditions suitable for optimal gene delivery. The formation of condensed peptide DNA complexes leads to resistance to nuclease degradation. The level of reporter gene expression obtained is dependent on the peptide-to-DNA ratio and is enhanced in the presence of the endosomal buffer chloroquine, polyethyleneimine, and deactivated adenovirus during gene delivery. Under optimal conditions the levels of reporter gene expression obtained approach or even exceed those obtained with DNA delivered with the commercial liposome Lipofectamine. The ability to produce an efficient gene delivery system using small, easily modified, and well-defined constructs that have no constraint of particle size demonstrates the advantages of integrin-targeting peptides for gene transfer.
Performance impact of partial reconfigurability in lightwave networks (2002)

Rearrangeable multihop lightwave networks can be dynamically reconfigured to adapt the connectivity among network stations to prevailing traffic conditions. Most of the literature has analyzed the performance of such networks assuming no limitations on the range of tunability of the transmitters and/or receivers allocated to each network station. Therefore, all connection diagrams could be realized among network stations, within the constraints of the number of transmitters and receivers at each station. Since the number of wavelengths in use may be very large, a practical implementation would restrict the tunability range of each transmitter and receiver to some limited set of contiguous wavelengths, or waveband. However, there is a penalty associated with such restrictions in that all connection diagrams might not be achievable and the network performances could degrade. The author derives lower bounds on the performance degradation experienced by the network when there are tunability limitations. He then proposes and analyzes a waveband assignment and grouping scheme, illustrating that one can design networks with good performance even though there are tunability constraints on the transceivers. He also describes other architectures (multi-fiber physical topology, subcarrier division multiplexing) for which the model and analysis readily apply.