gebhart/patrepeval huggingface dataset:
Low-Dose Interferon-α in Chronic Myeloid Leukemia (1995)

Letters1 May 1995Low-Dose Interferon-α in Chronic Myeloid LeukemiaJill R. Schofield and William A. RobinsonJill R. SchofieldUniversity of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this author and William A. RobinsonUniversity of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-9-199505010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Talpaz and Kantarjian for their comments and questions about our recent article on low-dose interferon-α therapy for chronic myeloid leukemia [1]. The unpublished results they cite are better than their previously published data [2, 3] and those of other groups that used similar interferon-α dosing schedules [1]. This includes the most recently published reports of randomized trials by the Italian Cooperative Study Group on Chronic Myeloid Leukemia [4] and by the German Chronic Myeloid Leukemia Group [5]. We are uncertain whether the data cited in their letter are from their original report or from an ...References1. Schofield JR, Robinson WA, Murphy JR, Rovira DK. Low doses of interferon-α are as effective as higher doses in inducing remissions and prolonging survival in chronic myeloid leukemia. Ann Intern Med. 1994; 121:736-44. Google Scholar2. Talpaz M, Kantarjian HM, McCredie K, Keating MJ, Trujillo J, Gutterman J. Clinical investigation of human α interferon in chronic myelogenous leukemia. Blood. 1987; 69:1280-8. Google Scholar3. Talpaz M, Kantarjian HM, Kurzrock R, Trujillo JM, Gutterman JU. Interferon α produces sustained cytogenetic responses in chronic myelogenous leukemia. Ann Intern Med. 1991; 114:532-8. Google Scholar4. The Italian Cooperative Study Group on Chronic Myeloid Leukemia. Interferon α-2A as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N Engl J Med. 1994; 330:820-5. Google Scholar5. Hehlmann R, Heimpel H, Hasford J, Kolb HJ, Pralle H, Hossfeld DK, et al. Randomized comparison of interferon α with busulfan and hydroxyurea in chronic myeloid leukemia. Blood. 1994; 84:4064-77. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas M.D. Anderson Cancer Center, Houston, TX 77030. University of Colorado Health Sciences Center, Denver, CO 80262. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1995Volume 122, Issue 9Page: 728-729KeywordsChronic myeloid leukemiaCytogeneticsPopulation statisticsRandomized trialsToxicity Issue Published: 1 May 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Low Oxygen Storage of Special Precooled ‘Kees Nelis’ and ‘Prominence’ Tulip Bulbs1 (1981)

Abstract Flowering of ‘Kees Nelis’ ( Tulipa gesneriana L.) tulip bulbs was not impaired after 4 weeks of storage at 17°C in either 3 or 5% oxygen. ‘Kees Nelis’ bulbs stored in air or 1% O 2 for 4 or 6 weeks and ‘Prominence’ bulbs stored at any reduced O 2 level for 4 or 6 weeks flowered unsatisfactorily. Bulbs specially precooled later in the forcing season yielded unsatisfactory flowering after storage at 17°C regardless of cultivar. Low O 2 levels (1 to 5%) reduced the respiration rate of bulbs stored at 17°C for 6 weeks compared to bulbs stored in air. Storage of ‘Kees Nelis’ bulbs for 3 weeks in air with 5 ppm ethylene caused flower abortion upon forcing. Three or 5% O 2 reduced ethylene-induced flower abortion during storage.
HNC's MatchPlus system (1992)

HNC is developing a neural network related approach to document retrieval called MatchPlus . Goals of this approach include high precision/recall performance, ease of use, incorporation of machine learning algorithms, and sensitivity to similarity of use .
Tec Family Kinases in Inflammation and Disease (2012)

Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.
Optical properties of astaxanthin solutions and aggregates (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical properties of astaxanthin solutions and aggregatesManuel. Buchwald and William P. JencksCite this: Biochemistry 1968, 7, 2, 834–843Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/bi00842a042https://doi.org/10.1021/bi00842a042research-articleACS PublicationsRequest reuse permissionsArticle Views1127Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The chronological life span of Saccharomyces cerevisiae (2003)

Simple model systems have played an important role in the discovery of fundamental mechanisms of aging. Studies in yeast, worms and fruit flies have resulted in the identification of proteins and signalling pathways that regulate stress resistance and longevity. New findings indicate that these pathways may have evolved to prevent damage and postpone aging during periods of starvation and may be conserved from yeast to mammals. We will review the yeast S. cerevisiae model system with emphasis on the chronological life span as a model system to study aging and the regulation of stress resistance in eukaryotes.
Infections Associated with the Genus Edwardsiella: the Role of Edwardsiella tarda in Human Disease (1993)

The role of the genus Edwardsiella in human illness is reviewed. Of the three recognized species, only Edwardsiella tarda has been demonstrated to be pathogenic for humans. Chief infections associated with this species include bacterial gastroenteritis, wound infections such as cellulitis or gas gangrene associated with trauma to mucosal surfaces, and systemic disease such as septicemia, meningitis, cholecystitis, and osteomyelitis. Risk factors that are associated with E. tarda infections include exposure to aquatic environments or exotic animals (e.g., reptiles or amphibia), preexisting liver disease, conditions leading to iron overload, and dietary habits (e.g., raw fish ingestion). Although studies indicate that this bacterium is susceptible to most commonly prescribed antibiotics, fatal gastrointestinal and extraintestinal infections have been described.
Oral Administration of β‐Lactamase Preserves Colonization Resistance of Piperacillin‐Treated Mice (2003)

We hypothesized that orally administered, recombinant class A beta-lactamase would inactivate the portion of parenteral piperacillin excreted into the intestinal tract, preserving colonization resistance of mice against nosocomial pathogens. Subcutaneous piperacillin or piperacillin plus oral beta-lactamase were administered 24 and 12 h before orogastric inoculation of piperacillin-resistant pathogens. Oral administration of beta-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens.
Buspirone in the Treatment of Tardive Dyskinesia (1993)

Eight patients with mild to severe tardive dyskinesia (TD) were treated for 12 weeks with buspirone in dosages of up to 180 mg/day in an open-label study. Changes in TD severity were assessed by the Abnormal Involuntary Movement Scale. The rater was blind to buspirone dosage. Buspirone was well tolerated by most subjects. A within-subjects comparison of pretreatment and post-treatment Abnormal Involuntary Movement Scale scores revealed a mean improvement of 4.4 (p < 0.01). Improvement was also observed in neuroleptic-induced extrapyramidal side effects such as parkinsonism and akathisia. Scores on the Hamilton Rating Scale for Anxiety and the Brief Psychiatric Rating Scale did not change during the 12-week study. The results of this open-label pilot study suggest that relatively high doses of buspirone may be efficacious in the treatment of TD.
Conformal, Amine-Functionalized Thin Films by Initiated Chemical Vapor Deposition (iCVD) for Hydrolytically Stable Microfluidic Devices (2010)

Poly(4-aminostyrene) (PAS) thin films were synthesized via initiated chemical vapor deposition (iCVD) with tert-butyl peroxide as the initiator, representing the first time that a library of iCVD functional groups has been extended to amine moieties. The retention of the pendent amine chemical functionality was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). Scanning electron microscope (SEM) reveals that the iCVD PAS coatings are conformal over nonplanar structures. Fluorescence microscopy and photoluminescence of quantum dot functionalized surfaces confirm that the reactive amine functional group density at the surface of iCVD PAS is ∼1 order of magnitude greater than for films grown by plasma-enhanced chemical vapor deposition (PECVD). The higher amine density of the iCVD films enables the formation of a robust nanoadhesive with complementary epoxy functional groups. Prototype microfluidic structures were fabricated using the low-temperature (50 °C) and zero-outgassing reaction between the amine groups in iCVD PAS and the epoxy groups in iCVD poly(glycidyl methacrylate) (PGMA). Bonded devices able to withstand >150 psi were achieved by combining polydimethylsiloxane (PDMS) and a variety of other materials including Si wafers, polycarbonate (PC), glass, polyethylene terephthalate (PET), polyethylene (PE), polyacrylate (PA), and cyclic olefin copolymer (COC). Additionally, the all-iCVD nanoadhesive bonding process displays high resistance against hydrolytic degradation (>2 weeks). Within the channels of the bonded devices, the epoxy and amine groups remain available for subsequent functionalization.
Buildup of Polymer/Au Nanoparticle Multilayer Thin Films Based on Hydrogen Bonding (2000)

We report two new hydrogen-bonding-based routes for layer-by-layer fabrication of polymer/Au nanoparticle multilayer thin films. Two types of Au nanoparticles surface-modified with carboxyl groups or pyridine groups were prepared in nonaqueous solvents. In the first assembly route, we consecutively adsorbed poly(4-vinylpyridine) (PVP) and Au nanoparticles with carboxyl group tailored surfaces. In the second route, we alternatively deposited poly(acrylic acid) (PAA) and Au nanoparticles with pyridine group tailored surfaces. The multilayer buildup was monitored by UV−vis spectroscopy, which showed a linear increase of the film absorbance with the number of adsorbed Au layers. FTIR spectroscopy was used to verify hydrogen bonding between the pyridine and carboxyl groups, which is believed to be the driving force for the formation of polymer/Au multilayer thin films.
Superconducting metamaterials (2005)

Evanescent wave amplification has been predicted under the ideal condition that the index of refraction, n=−1+i0 precisely, but is difficult to observe in practice because current metamaterials suffer from high losses. We present experimental results on a metamaterial that employs superconducting Nb metals and low-loss dielectric materials. Results include transmission data on a wire, split-ring resonator, and a combination medium at temperatures between 4.2 and 297K. Evidence of negative effective permittivity, permeability, and a negative effective index passband are seen in the superconducting state between 50MHz and 18GHz. We find a dielectric loss of εeff,2=2.6×10−3 in a superconducting wire array at 10.75GHz.
Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion (2001)

The srtA gene product, SrtA, has been shown to be required for cell wall anchoring of protein A as well as virulence in the pathogenic bacterium Staphylococcus aureus. There are five major mechanisms for displaying proteins at the surface of gram-positive bacteria (P. Cossart and R. Jonquieres, Proc. Natl. Acad. Sci. USA 97:5013-5015, 2000). However, since many of the known surface proteins of gram-positive bacteria are believed to be exported and anchored via the sortase pathway, it was of interest to determine if srtA plays a similar role in other gram-positive bacteria. To that end, the srtA gene in the human oral commensal organism Streptococcus gordonii was insertionally inactivated. The srtA mutant S. gordonii exhibited a marked reduction in quantity of a specific anchored surface protein. Furthermore, the srtA mutant had reduced binding to immobilized human fibronectin and had a decreased ability to colonize the oral mucosa of mice. Taken together, these results suggest that the activity of SrtA plays an important role in the biology of nonpathogenic as well as pathogenic gram-positive cocci.
A kindred exhibiting cosegregation of an overlap connective tissue disorder and the chromosome 16 linked form of autosomal dominant polycystic kidney disease. (1993)

Autosomal dominant polycystic kidney disease (ADPKD) is a disorder of adult onset manifested by bilaterally enlarged cystic kidneys frequently associated with progressive renal failure. The mutated gene (PKD1) responsible for 85 to 95% of cases has been localized to a small segment on the distal tip of the short arm of chromosome 16. A clinical spectrum of heritable connective tissue disorders that remain unclassifiable under the present nosology but that contain elements of the Marfan's syndrome have previously been described. The genetic localization and molecular basis of such overlap connective tissue disorders (OCTD) have not been elucidated. In this report, a kindred in which ADPKD and OCTD appear to cosegregate is described. The connective tissue phenotype in this family includes aortic root dilation, aortic and vertebral artery aneurysms with dissection, and aortic valve incompetence, as well as pectus abnormalities, pes planus, joint laxity, arachnodactyly, scoliosis, dolichostenomelia, and high arched palate. ADPKD was manifest primarily as bilateral renal cysts with or without renal failure. The DNA of all living family members was studied with markers recognizing polymorphic loci flanking the PKD1 region (3'HVR and O90a), as well as markers from the loci of chromosomes 15 and 5, associated with fibrillin genes FBN1 and FBN2, respectively. In this kindred of 20 family members traced through five generations, cosegregation of ADPKD and the OCTD phenotype was observed in 12 of 12 meioses and 3 of 3 phase known. Both markers for PKD1 were tightly linked to both ADPKD and OCTD, whereas there was no evidence for linkage with either fibrillin locus. In this family, the ADPKD and OCTD mutations are genetically linked. The presence of OCTD with ADPKD identifies a group of patients at significantly greater risk for sudden death from aortic root and other vascular aneurysmal dissection and rupture.
Methotrexate in nonrenal lupus and undifferentiated connective tissue disease--a review of 36 patients. (1996)

MTX is useful in the treatment of some patients with mild manifestations of SLE, with an acceptable toxicity profile, but only modest steroid sparing potential. Patients with dermatitis and arthritis appear to have the best chance of responding to MTX therapy.
Biosynthetic relationships of the chondroitin sulfate proteoglycan with Ia and invariant chain glycoproteins. (1985)

As a first step to elucidating the role of the Ia-associated chondroitin sulfate proteoglycan (CSPG) in the biology of the Ia antigens, we have studied several aspects of the interactions of the CSPG with the Ia/invariant chain glycoproteins. These studies revealed that at any time point, only 2 to 5% of Ia molecules were associated with the CSPG, and that this fraction included Ia molecules that were expressed at the cell surface. Pulse-chase studies indicated that the association of Ia molecules and the CSPG was rapid and short lived. Newly synthesized [35S]sulfate-labeled CSPG molecules were detected in association with Ia molecules immediately after a 15-min pulse, but were barely detectable after a 30-min chase, and were completely undetectable after a 60-min chase. Similarly, newly synthesized [3H]leucine-labeled Ia molecules associated with the CSPG were detectable immediately after a 20-min pulse, and after a 75-min chase, but could not be detected in association with the CSPG after a 300-min chase. Virtually no CSPG that was similar in size to that associated with Ia molecules was found free in the cells or was secreted into the media. The results in this report are compatible with the hypothesis that some or all of the Ia molecules associate transiently with the CSPG, or that a small fraction of Ia molecules associate permanently with the CSPG in a short-lived complex. These studies tend to favor a role for the CSPG in the biosynthesis of Ia rather than in intracellular trafficking or in intercellular communication.
Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis (2010)

Aspergillus species are a major worldwide cause of corneal ulcers, resulting in visual impairment and blindness in immunocompetent individuals. To enhance our understanding of the pathogenesis of Aspergillus keratitis, we developed a murine model in which red fluorescent protein (RFP)-expressing A. fumigatus (Af293.1RFP) conidia are injected into the corneal stroma, and disease progression and fungal survival are tracked over time. Using Mafia mice in which c-fms expressing macrophages and dendritic cells can be induced to undergo apoptosis, we demonstrated that the presence of resident corneal macrophages is essential for production of IL-1beta and CXCL1/KC, and for recruitment of neutrophils and mononuclear cells into the corneal stroma. We found that beta-glucan was highly expressed on germinating conidia and hyphae in the cornea stroma, and that both Dectin-1 and phospho-Syk were up-regulated in infected corneas. Additionally, we show that infected Dectin-1(-/-) corneas have impaired IL-1beta and CXCL1/KC production, resulting in diminished cellular infiltration and fungal clearance compared with control mice, especially during infection with clinical isolates expressing high beta-glucan. In contrast to Dectin 1(-/-) mice, cellular infiltration into infected TLR2(-/-), TLR4(-/-), and MD-2(-/-) mice corneas was unimpaired, indicating no role for these receptors in cell recruitment; however, fungal killing was significantly reduced in TLR4(-/-) mice, but not TLR2(-/-) or MD-2(-/-) mice. We also found that TRIF(-/-) and TIRAP(-/-) mice exhibited no fungal-killing defects, but that MyD88(-/-) and IL-1R1(-/-) mice were unable to regulate fungal growth. In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.
Silenced suppressor of cytokine signaling 1 (SOCS1) enhances the maturation and antifungal immunity of dendritic cells in response to Candida albicans in vitro (2014)

Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility to enhance the potency of DC-based immunotherapy is to silence the negative immunoregulatory pathways through the ablation suppressor of cytokine signaling suppressor 1 (SOCS1). Here, we deliver small interfering RNA (siRNA) against SOCS1 into murine bone marrow DCs, and as a consequence, we investigate the maturation/action of DCs and the subsequent T cell response after exposure to C. albicans. Our results show that the maturation of DCs (i.e., expressions of CD80, CD40, CD86, and MHC II) are significantly increased in the silenced SOCS1 treatment group after exposure to C. albicans. As a result, suppression of the SOCS1 promotes the greatest expression of IFN-γ and IL-12, and reduces IL-4 secretions, which induce CD4+ cell Th1 differentiation but inactivate Th2 cell development. The responses of IL-6 and TNF-β consist of up-regulation in the presence of C. albicans, but this is not specific to SOCS1 silencing, suggesting that these cytokines are not regulated by the SOCS1 gene in fungal infections. We find Th17 differentiation is unchanged regardless of SOCS1 inhibition. The increase in phagocytosis and killing of C. albicans in SOCS1 gene-treated DCs indicate a role for this cytokine suppressor in innate immunity as well. In conclusion, our findings support the view that SOCS1 protein is a critical inhibitory molecule for controlling cytokine response and antigen presentation by DCs, thereby regulating the magnitude of innate and adaptive immunities by generating IFN-γ-production T cells (Th1)—but not Th17—from naïve CD4+ T cells. Our study demonstrates that SOCS1 siRNA can serve as a useful vehicle to modulate the function of DCs against C. albicans infection.
Elimination of drift in a single-mode optical fiber interferometer using a piezoelectrically stretched coiled fiber (1980)

The feasibility of maintaining a single-mode optical fiber interferometer in quadrature is demonstrated using a servo driven piezoelectrically stretched coiled fiber. The controller has a range of ~10(-5)-1000 rad with a stress voltage coefficient of ~27pi rad/V.