gebhart/patrepeval huggingface dataset:
Managing Performance Overhead of Virtual Machines in Cloud Computing: A Survey, State of the Art, and Future Directions (2014)

Infrastructure-as-a-Service (IaaS) cloud computing offers customers (tenants) a scalable and economical way to provision virtual machines (VMs) on demand while charging them only for the leased computing resources by time. However, due to the VM contention on shared computing resources in datacenters, this new computing paradigm inevitably brings noticeable performance overhead (i.e., unpredictable performance) of VMs to tenants, which has become one of the primary issues of the IaaS cloud. Consequently, increasing efforts have recently been devoted to guaranteeing VM performance for tenants. In this survey, we review the state-of-the-art research on managing the performance overhead of VMs, and summarize them under diverse scenarios of the IaaS cloud, ranging from the single-server virtualization, a single mega datacenter, to multiple geodistributed datacenters. Specifically, we unveil the causes of VM performance overhead by illustrating representative scenarios, discuss the performance modeling methods with a particular focus on their accuracy and cost, and compare the overhead mitigation techniques by identifying their effectiveness and implementation complexity. With the obtained insights into the pros and cons of each existing solution, we further bring forth future research challenges pertinent to the modeling methods and mitigation techniques of VM performance overhead in the IaaS cloud.
Adaptive Impedance-Matching Techniques for ControllingLNetworks (2009)

The link quality of mobile phones suffers from antenna mismatch due to fluctuating body effects. Techniques for adaptive control of impedance-matching <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">L</i> networks are presented, which provide automatic compensation of antenna mismatch. To secure reliable convergence, a cascade of two control loops is proposed for independent control of the real and imaginary parts of impedance. A secondary feedback path is used to enforce operation into a stable region when needed. These techniques exploit the basic properties of tunable series and parallel <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LC</i> networks. A generic quadrature detector that offers a power-independent orthogonal reading of the complex impedance value is presented, which is used for direct control of variable capacitors. This approach renders calibration and elaborate software computation superfluous and allows for autonomous operation of adaptive antenna-matching modules.
Sublingual Lorazepam in Childhood Serial Seizures (1988)

Sublingual lorazepam was successful in controlling serial seizures in ten children. There was both intrasubject and intersubject variability in the effective dose, which ranged from about 0.05 mg/kg to 0.15 mg/kg. Side effects were minimal and consisted of drowsiness, unsteadiness, nausea, and hyperactivity. Sublingual lorazepam is an easy and effective way to treat serial seizures at home.
Theory of the ground-state spin of the NV−center in diamond (2012)

The ground-state spin of the negatively charged nitrogen-vacancy center in diamond has been the platform for the recent rapid expansion of new frontiers in quantum metrology and solid-state quantum-information processing. However, in spite of its many outstanding demonstrations, the theory of the spin has not yet been fully developed, and there do not currently exist thorough explanations for many of its properties, such as the anisotropy of the electron $g$ factor and the existence of Stark effects and strain splittings. In this work, the theory of the ground-state spin is fully developed using the molecular orbital theory of the center in order to provide detailed explanations for the spin's fine and hyperfine structures and its interactions with electric, magnetic, and strain fields. Given these explanations, a general solution is obtained for the spin in any given electric-magnetic-strain field configuration, and the effects of the fields on the spin's coherent evolution, relaxation, and inhomogeneous dephasing are examined. Thus, this work provides the essential theoretical tools for the precise control and modeling of this remarkable spin in its current and future applications.
Alterations in the heart lysosomal stability in isoproterenol induced myocardial infarction in rats. (1990)

The alterations in the heart lysosomal stability following isoproterenol induced myocardial infarction were studied in albino rats. The rate of release of beta-glucuronidase at various time intervals at 37 degrees C from lysosome rich fraction was taken as a measure of lysosomal stability. As compared to the control day one, three and five samples exhibited a significant increase in beta-glucuronidase activity at all the time intervals. The subcellular distribution of beta-glucuronidase was also studied and the soluble and total activities exhibited an increase at peak infarction stage and returned to normal during the recovery. The decrease in the lysosomal stability might be attributed to the increased beta-glucuronidase activity observed following myocardial infarction.
Two-Stream Approximations to Radiative Transfer in Planetary Atmospheres: A Unified Description of Existing Methods and a New Improvement (1980)

Existing two-stream approximations to radiative transfer theory for particulate media are shown to be represented by identical forms of coupled differential equations if the intensity is replaced by integrals of the intensity over hemispheres. One set of solutions thus suffices for all methods and provides convenient analytical comparisons. The equations also suggest modifications of the standard techniques so as to duplicate exact solutions for thin atmospheres and thus permit accurate determinations of the effects of typical aerosol layers. Numerical results for the plane albedos of plane-parallel atmospheres (single-scattering albedo = 0.8, 1.0; optical thickness = 0.25, 1, 4. 16; Henyey-Greenstein phase function with asymmetry factor 0.75) are given for conventional and modified Eddington approximations, conventional and modified two-point quadrature schemes, the hemispheric-constant method and the delta-function method, all for comparison with accurate discrete-ordinate solutions. A new two-stream approximation is introduced that reduces to the modified Eddington approximation in the limit of isotropic phase functions and to the exact solution in the limit of extreme anisotropic scattering. Comparisons of plane albedos and transmittances show the new method to be generally superior over a wide range of atmospheric conditions (including cloud and aerosol layers), especially in the case of nonconservative scattering.
Activation of human monocyte tumoricidal activity by C-reactive protein. (1987)

We examined the effect of purified human C-reactive protein (CRP) on induction of human peripheral blood monocyte (Mo)-mediated cytotoxicity (CTX) and oxidative metabolism. Exposure of Mo to acute phase serum levels of CRP in vitro resulted in dose-dependent expression of CTX against human tumor cell lines. Nonneoplastic human fibroblasts and glial cells were not affected by CRP-exposed Mo, and treatment of Mo monolayers with anti-Leu 11b (a natural killer marker) and complement did not abrogate or diminish CTX. Tumoricidal activity was observed after 20-44 h of Mo exposure to CRP, and after 48-72 h of coculture with radiolabeled target tumor cells. Mo exposed to CRP for 48 h also demonstrated elevated superoxide anion production when challenged with phorbol myristate acetate. Unlike CTX induced by lipopolysaccharide, CRP-induced CTX was completely inhibited by preincubation of CRP with phosphorylcholine, a CRP ligand, at a concentration of 5.5 molecules phosphorylcholine per molecule CRP. Further, when Mo medium (which contained 5% human AB serum) was preincubated with immobilized CRP, exposure of Mo to CRP in such medium did not result in CTX. In contrast, LPS-induced CTX was not affected. CRP-induced Mo CTX was observed, however, when Mo were exposed to CRP in medium preincubated with phosphorylcholine-treated immobilized CRP, suggesting that an active serum component which complexed with CRP was not removed. These findings indicate that one of the functions of the acute phase protein, CRP, may be to active Mo and that the process may require a CRP-binding serum component.
Development and Testing of a Bacterial Biosensor for Toluene-Based Environmental Contaminants (1998)

A bacterial biosensor for benzene, toluene, and similar compounds has been constructed, characterized, and field tested on contaminated water and soil. The biosensor is based on a plasmid incorporating the transcriptional activator xylR from the TOL plasmid of Pseudomonas putida mt-2. The XylR protein binds a subset of toluene-like compounds and activates transcription at its promoter, Pu. A reporter plasmid was constructed by placing the luc gene for firefly luciferase under the control of XylR and Pu. When Escherichia coli cells were transformed with this plasmid vector, luminescence from the cells was induced in the presence of benzene, toluene, xylenes, and similar molecules. Accurate concentration dependencies of luminescence were obtained and exhibited K1/2 values ranging from 39.0 +/- 3.8 microM for 3-xylene to 2,690 +/- 160 microM for 3-methylbenzylalcohol (means +/- standard deviations). The luminescence response was specific for only toluene-like molecules that bind to and activate XylR. The biosensor cells were field tested on deep aquifer water, for which contaminant levels were known, and were able to accurately detect toluene derivative contamination in this water. The biosensor cells were also shown to detect BETX (benzene, toluene, and xylene) contamination in soil samples. These results demonstrate the capability of such a bacterial biosensor to accurately measure environmental contaminants and suggest a potential for its inexpensive application in field-ready assays.
Sudden Cardiac Death in Patients with Chronic Kidney Disease: Prevention Is the sine qua non (2011)

Despite developments in the technology of dialysis procedures and improvements in the understanding of systemic derangements related to chronic kidney disease (CKD), cardiovascular disease is the major cause of death. Unfortunately, the leading subset of cardiovascular disease death is sudden cardiac death (SCD). To date much effort has been exerted to figure out the clues pointing to the risk of future development of SCD in patients with CKD. However, none of these factors satisfactorily detects a truly vulnerable dialysis patient. Thus, recently, it has been advocated that a combination of noninvasive risk assessment methods, carefully chosen to reflect the different aspects of the underlying pathology and changes in the myocardial substrate in CKD, could help to identify patients at high risk of SCD within the CKD. In this review, we aimed to summarize what is known about risk stratification of patients with CKD and appropriate prevention strategies with a special emphasis on recent developments and the use of complimentary tests perhaps as a risk prediction rule.
T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF. (1981)

IgG-secretion was induced in a human B blastoid cell line, CESS, by the addition of partially purified T cell-derived helper factor(s) (TRF), which had been obtained from PHA-stimulated human T cells. The number of IgG-producing cells in CESS cells reached its maximal level (10% of total cells) within 48 hr after the addition of TRF. TRF did not affect the proliferation of CESS cells and the block of cell proliferation with hydroxyurea did not inhibit the increase of IgG-producing cells, showing that TRF induced IgG-production in CESS cells without any requirement of cell division. TRF activity was completely removed by CESS cells but TCGF-activity in the same preparation was not absorbed with CESS cells. On the other hand, TCGF-dependent human killer cells absorbed TCGF activity but not TRF activity in the same preparation. The binding of 125I-labeled factor(s) on CESS cells was also demonstrated. These results showed the presence of acceptors for TRF on the surface of CESS cells and this cell line will provide useful means for the chemical characterization of acceptors and for the study of the mechanisms of the signal transmission through acceptors.
Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C (2016)

Trioxacarcins DC-45-A2, DC-45-A1, A, D, C7″-epi-C, and C have been synthesized through stereoselective strategies involving BF3·Et2O-catalyzed ketone-epoxide opening and gold-catalyzed glycosylation reactions, and the full structural assignment of trioxacacin C was deciphered via the syntheses of both of its C7″ epimers. The gathered knowledge sets the foundation for the design, synthesis, and biological evalution of analogues of these natural products as potential payloads for antibody-drug conjugates and other delivery systems for targeted and personalized cancer chemotherapy.
High performance organic light-emitting diodes based on tetra(methoxy)-containing anthracene derivatives as a hole transport and electron-blocking layer (2010)

A series of 2,3;6,7-tetra(methoxy)-9,10-di(aryl)anthracene derivatives have been readily synthesized by acid-catalyzed Friedel-Crafts alkylation of aromatic aldehydes with veratrole. These compounds have good thermal and morphological stability. Their highest occupied molecular orbital (HOMO: −5.23– −5.28 eV)/lowest unoccupied molecular orbital (LUMO: −2.11– −2.28 eV) energy levels are energetically favorable for use as hole-transporting/electron-blocking layers in organic light-emitting devices (OLEDs). Device performance of these non-amine based hole-transporting materials were comparable to or better than that of the traditional arylamine derivative NPB. The optimized green doped three-layer device based on 2,3;6,7-tetra(methoxy)-9,10-di(1-naphthyl)anthracene (TMOADN) exhibited a current efficiency of 25.6 cd A−1 (13.4 lm W−1) at 20 mA cm−2 with an external quantum efficiency of 7.05%.
Alcoholism and the Working-class Man (1991)

Abstract There were also key areas in which medical knowledge had an important impact in undermining the perception of masculine moral agency. This chapter discusses the contemporary debate surrounding alcoholism, a disease concept which, in contrast to hysteria, was almost always associated with the working-class male. An important characterization of a morally depraved and biologically degenerate working man impinged significantly on the outcome of individual cases. It also contributed to the development of criminology as a specialized politique criminelle, which was more concerned to eradicate undesirables than to reform the seemingly irretrievable according to the dictates of social defence philosophy. The analysis of alcoholism and drunken violence concentrates on men. Between 1880 and 1910, approximately 25 per cent of Paris cases of actual or attempted murders were committed by those who either cited alcohol as an excuse, had a drinking habit, or had been drinking before the crime.
The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis (2013)

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by clinical homogeneity among patients, an overwhelming female predominance, production of a multilineage immune response to mitochondrial autoantigens, inflammation of small bile ducts, and in some patients the development of fibrosis and cirrhosis. The targets in this disease are small bile ducts, and the prototypic serologic response includes antimitochondrial antibodies (AMAs). Several key observations have greatly advanced our understanding of PBC. First, the multilineage immune response, including AMAs, is directed at the E2 component of the 2-oxo-dehydrogenase pathway, particularly PDC-E2. Second, such autoantibodies may be identified years before the clinical diagnosis of disease. Third, the autoreactive T cell precursor frequency for both CD4 and CD8 cells is significantly higher in liver and regional lymph node than in blood, so the multilineage antimitochondrial response may be required for the development of this disease. Fourth, the apotope of biliary cells contains intact PDC-E2; this apotope, in a setting that includes granulocyte macrophage colony-stimulating factor-stimulated macrophages and AMAs, produces an intense proinflammatory response. Fifth, several mouse models of PBC highlight the importance of loss of tolerance to PDC-E2 as well as a critical role for the interleukin (IL)-12 signaling pathway. Finally, genome-wide association studies suggest an important role for the IL-12 pathway in disease susceptibility. Taken together, these findings have resulted in a better understanding of the mechanism for selective biliary cell destruction and have also suggested unique pathways for therapeutic intervention.
Modeling by example (2004)

In this paper, we investigate a data-driven synthesis approach to constructing 3D geometric surface models. We provide methods with which a user can search a large database of 3D meshes to find parts of interest, cut the desired parts out of the meshes with intelligent scissoring, and composite them together in different ways to form new objects. The main benefit of this approach is that it is both easy to learn and able to produce highly detailed geometric models -- the conceptual design for new models comes from the user, while the geometric details come from examples in the database. The focus of the paper is on the main research issues motivated by the proposed approach: (1) interactive segmentation of 3D surfaces, (2) shape-based search to find 3D models with parts matching a query, and (3) composition of parts to form new models. We provide new research contributions on all three topics and incorporate them into a prototype modeling system. Experience with our prototype system indicates that it allows untrained users to create interesting and detailed 3D models.
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder (2011)

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10(-9)). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10(-6)). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases (P = 4.38 × 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts.
Constitutive multiple drug resistance in tumor stem cells (2005)

2047 Failure to eradicate cancer may be as fundamental as a misidentification of the target. Current therapies succeed at eliminating bulky disease and proliferating cells, but miss a tumor reservoir that leads to disease recurrence and metastasis. Advances in the understanding of normal tissue development and repair provide a basis for revisiting oncogenesis, tumor heterogeneity, and drug resistance. In order to test the hypothesis that tumor stem cells, small resting cells with the stem cell-like properties of self-renewal, protection, and apoptosis resistance, exist as rare populations in heterogeneous tumors, we used flow cytometry to simultaneously measure tumor and stem cell markers, and constitutive multiple drug resistance transporter expression and activity ( side population ) in cancer specimens (breast, ovarian, lung, colon, renal, prostate). We concentrated on pleural effusions and ascites, where analysis is not confounded by the presence of normal tissue stem cells. In all cases (n=28) we have succeeded in detecting cytokeratin+, ESA+, CD45-, MDR+ tumor cells of small resting morphology. Building on the findings of the Clarke laboratory, we have shown that these cells are contained within the tumorigenic CD44+/CD24 negative or dim population. Small resting tumor cells are cytokeratin dim, exclusively display P-gp (ABCC1) activity (rhodamine 123 transport) and also express the classical stem cell markers c-kit (CD117), Thy-1 (CD90) and the MDR transporter ABCG2 (BCRP1). This population represents the best candidate for the resting tumor stem cell and is present in pleural effusions at a frequency of ∼1/100,000 cells. In ovarian and breast cancer we have isolated this subset and demonstrated long-term in vitro clonogenicity at frequencies
Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML (2013)

CD33 is a valid target for acute myeloid leukemia (AML) but has proven challenging for antibody-drug conjugates. Herein, we investigated the cellular determinants for the activity of the novel CD33/CD3-directed bispecific T-cell engager antibody, AMG 330. In the presence of T cells, AMG 330 was highly active against human AML cell lines and primary AML cells in a dose- and effector to target cell ratio-dependent manner. Using cell lines engineered to express wild-type CD33 at increased levels, we found a quantitative relationship between AMG 330 cytotoxicity and CD33 expression; in contrast, AMG 330 cytotoxicity was neither affected by common CD33 single nucleotide polymorphisms nor expression of the adenosine triphosphate-binding cassette (ABC) transporter proteins, P-glycoprotein or breast cancer resistance protein. Unlike bivalent CD33 antibodies, AMG 330 did not reduce surface CD33 expression. The epigenetic modifier drugs, panobinostat and azacitidine, increased CD33 expression in some cell lines and augmented AMG 330-induced cytotoxicity. These findings demonstrate that AMG 330 has potent CD33-dependent cytolytic activity in vitro, which can be further enhanced with other clinically available therapeutics. As it neither modulates CD33 expression nor is affected by ABC transporter activity, AMG 330 is highly promising for clinical exploration as it may overcome some limitations of previous CD33-targeted agents.
[Role of radiofrequency ablation in atrial fibrillation]. (2002)

Atrial fibrillation is the most frequently encountered arrhythmia in the human species. Its danger is widely appreciated but it remains for certain patients and their practitioners an awkward or even exasperating problem. Only surgery and radiofrequency ablation allow certain patients to be cured. The surgical approach is of course warranted in the case of an otherwise necessary cardiac intervention. In the absence of a surgical indication, endovenous ablation, which is less aggressive, is preferred. The procedure consists of disconnecting the pulmonary veins which "house" 80 to 95% of the foci, together with the ablation of further non-venous foci, which are always difficult to treat. Side effects in experimental centres are rare and 70% of patients are cured, which allows cessation of antiarrhythmic and anticoagulant treatments. The procedure is currently offered to symptomatic patients having had at least one episode every ten days in spite of antiarrhythmics.