gebhart/patrepeval huggingface dataset:
Theratope® vaccine (STn-KLH) (2001)

Active specific immunotherapy (ASI) is a promising approach to treating cancer. Numerous studies in the laboratory have demonstrated that various cancer vaccines can stimulate antibody and cell mediated immune responses against tumour-associated antigens [1-9]. Yet few studies have demonstrated convincing clinical responses. Sialyl-Tn (STn) is a carbohydrate associated with the MUC1 mucin on a number of human cancer cells and is associated with more aggressive disease. Consequently, STn is an ideal candidate for ASI therapy. Theratope vaccine is a cancer vaccine that was designed by Biomira, Inc. (Edmonton, Alberta, Canada) by incorporating a synthetic STn antigen that emulates the carbohydrate seen on human tumours. The clinical trials conducted to date with Theratope vaccine are outlined in this report. Overall, Theratope vaccine has been well-tolerated with minimal toxicity. The most common side effects have been in duration and erythema at the site of injections. Both in a non-transplant setting following low dose iv. cyclophosphamide and high dose autologous transplant setting, there has been a trend toward Theratope vaccine decreasing the risk for relapse, prolonging the time to relapse and thus impacting on overall survival. The definitive Phase III trial comparing the outcome of patients with metastatic breast cancer receiving vaccinations with Theratope vaccine versus vaccination with the nonspecific immune stimulants Keyhole Limpet Hemocyanin (KLH) and Detox -B stable emulsion (Detox-B) (now called Enhanzyn Immunostimulant) was closed to enrolment on March 30, 2001. Over 1000 women with distant metastatic breast cancer were enrolled into the program.
Nanotube Formation by Hydrophobic Dipeptides (2001)

A wide range of applications has been suggested for peptide-based nanotubes, which first attracted considerable interest as model systems for membrane channels and pores. The intriguing and unprecedented observation of nanotube formation by supramolecular self-assembly of the four dipeptides L-Leu-L-Leu, L-Leu-L-Phe, L-Phe-L-Leu and L-Phe-L-Phe is described here. These simple compounds crystallize with hydrogen-bonded head-to-tail chains in the shape of helices with four to six peptide molecules per turn. The resulting structures have chiral hydrophilic channels with a van der Waals' diameter up to 10 A.
The Multiplex Function of Nitric Oxide in (Auto)immunity (1998)

Study of the role of nitric oxide (NO) in mammalian organisms has a history of complexities. When eukaryotic cells were demonstrated to generate NO from the aminoacid l-arginine, we were first stunned and then fascinated by the idea that a molecule with such a simple structure exerts messenger
Load shedding for aggregation queries over data streams (2004)

Systems for processing continuous monitoring queries over data streams must be adaptive because data streams are often bursty and data characteristics may vary over time. We focus on one particular type of adaptivity: the ability to gracefully degrade performance via "load shedding" (dropping unprocessed tuples to reduce system load) when the demands placed on the system cannot be met in full given available resources. Focusing on aggregation queries, we present algorithms that determine at what points in a query plan should load shedding be performed and what amount of load should be shed at each point in order to minimize the degree of inaccuracy introduced into query answers. We report the results of experiments that validate our analytical conclusions.
Interaction between Soluble Type I Receptor for Bone Morphogenetic Protein and Bone Morphogenetic Protein-4 (1997)

Bone morphogenetic proteins (BMPs) are multifunctional proteins that comprise the largest subfamily of the transforming growth factor-beta. These proteins bind to types I and II serine/threonine kinase receptors. Ligand-induced heteromeric dimerization of these receptors is the key event in initiation of biological responses. We report here large-scale expression and purification of extracellular domain of the type I receptor for BMP-2/4, using a silkworm expression system. This soluble form of BMP receptor (sBMPR) was in monomer form in solution and bound to BMP-4 but not to activin or transforming growth factor-beta1. Surface plasmon resonance studies showed that kinetic parameters of sBMPR for BMP-4 consisted of a relatively rapid association rate constant (ka = 3.81 +/- 0.19 x 10(4) s-1 M-1) and an extremely slow dissociation rate constant (kd = 3.69 +/- 0.26 x 10(-4) s-1). From these two kinetic parameters, affinity was determined to be similar to that of the intact membrane-associated receptor expressed on COS cells. sBMPR inhibited the alkaline phosphatase activity in BMP responsive cell lines such as mouse osteoblastic cell MC3T3-E1 and bone marrow stromal cell ST2. These data indicate that the extracellular domain of type I receptor for BMP-2 and BMP-4 is sufficient for high-affinity binding to its ligands and should prove useful in understanding the role of BMP-2/4 in vivo, because a suitable high-affinity anti-BMP antibody has yet to be developed.
5% lidocaine-medicated plaster vs other relevant interventions and placebo for post-herpetic neuralgia (PHN): a systematic review (2010)

Several pharmacological treatments are used to manage post-herpetic neuralgia (PHN). The use of topical analgesics, such as 5% lidocaine-medicated plaster (5% LMP), may be preferable to systemic treatments in that they are formulated to produce a local pain relieving effect with minimal systemic absorption. However, direct head-to-head comparisons are relatively few, and a rigorous assessment of the relative efficacy and safety of the various treatment options is lacking. The objective of this study was to compare 5% LMP for the relief of PHN with other relevant interventions and placebo. Six databases were searched up to May 2010. Quantitative methods for data synthesis were used, and a network meta-analysis was conducted. Twenty unique studies (32 publications) were included. Placebo-controlled studies showed 5% LMP to be effective in providing pain relief and reducing allodynia while adverse event rates were generally low. A comparison between 5% LMP and pregabalin indicated the non-inferiority of 5% LMP for pain reduction and showed greater improvement of quality of life for 5% LMP. Adverse events (AE) were significantly fewer with 5% LMP. In the network meta-analysis, only 5% LMP and gabapentin were associated with a greater change in pain from baseline than placebo [-15.50 (95% CI -18.85 to -12.16) and -7.56 (95% CI -12.52 to -2.59) respectively]. 5% LMP was shown to be more effective than capsaicin [-16.45 (95% CI -20.04 to -12.86)], gabapentin [-7.95 (95% CI -13.29 to -2.61)] and pregabalin [-13.45 (95% CI -19.19 to -7.71)]. For pain relief, two comparators were more effective than placebo [mean pain relief, gabapentin: 32.77 (95% CI 15.57-49.97); 5% LMP: 26.77 (95% CI 9.11-44.43)]. 5% LMP was shown to be comparable to gabapentin [-6.00 (95% CI -25.32-13.32)]. The results suggest that 5% LMP and gabapentin have similar effects on pain relief and that 5% LMP is more effective than capsaicin and pregabalin (change in pain from baseline). Topical agents, such as 5% LMP, are associated with fewer and less clinically significant AE than is the case for systemic agents. However, small numbers, and limited size and quality of included studies should be taken into account. Further studies are needed.
P0-3 Focused Ultrasound-Induced Molecular Delivery through the Blood-Brain Barrier (2007)

The delivery of gadolinium through the ultrasound- induced blood-brain barrier (BBB) openings of mice was investigated. The left hippocampus of mice (n=13) was sonicated (frequency: 1.525 MHz, pressure amplitude: 0.64 MPa, duty cycle: 20%, duration: 1 minute) in vivo through the intact skin and skull after the injection of pre-formed microbubbles (SonoVuereg; 25-30 mul). The BBB opening in mice was studied using MRI (p=3) and fluorescent microscopy (q=10). High- resolution MRI (9.4 Tesla, in-plane resolution: 75 times 84 mum, scan time: 110 min) were acquired 60-90 min post-sonication before and after intraperitoneally injection of gadolinium (Omniscantrade; 0.75 ml, molecular weight: 573.7 Da). Four to ten minutes post- sonication, fluorescent dextran of various molecular weights (3,000, 70,000, and 2,000,000 Da) were delivered intravenously. MRI revealed contrast-enhancement and dextran revealed fluorescence following BBB opening. The gadolinium and dextran were nonuniformly distributed within the sonicated region. More specifically, contrast enhancement and fluorescence was more pronounced at different regions. The MRI procedure was repeated one day after opening and revealed BBB closure in the hippocampal region. In conclusion, gadolinium was deposited through the transiently opened BBB in the left hippocampus of mice using a single-element FUS transducer. The BBB opening and closing behaviors, and the size of BBB opening were dependent on the region sonicated. Molecules of smaller molecular weight were more uniformly deposited throughout the hippocampus than larger molecules.
Open-Cell Metallic Porous Materials Obtained Through Space Holders—Part I: Production Methods. A Review (2016)

This article presents a review of current methods for production of metallic open-cell porous materials through space holders. The methods are divided into two major groups: on the basis of sintering and using liquid phase processing. Details about technologies are given, and their relations to structure parameters of obtained materials are discussed. Methods with 11 different space holders are described. The space holders could be metallic or nonmetallic (organic and inorganic) materials which could be leached or burned depending on removal technique. It is concluded that the flexible application of different space holders offers opportunities for obtaining large variety of metallic porous structures. A new line of development should be elaboration of complex techniques for production of porous structure with graded pore size and/or porosity which will meet various engineering requirements and will open new possibilities for applications as functional and structural elements. The next part of this work is devoted to the structure, the properties, and application of the open-cells porous materials obtained through space holders.
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides (1984)

The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides (III) is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
Intrinsic Material Properties Dictating Oxygen Vacancy Formation Energetics in Metal Oxides (2015)

Oxygen vacancies (V(O)) in oxides are extensively used to manipulate vital material properties. Although methods to predict defect formation energies have advanced significantly, an understanding of the intrinsic material properties that govern defect energetics lags. We use first-principles calculations to study the connection between intrinsic (bulk) material properties and the energy to form a single, charge neutral oxygen vacancy (E(V)). We investigate 45 binary and ternary oxides and find that a simple model which combines (i) the oxide enthalpy of formation (ΔH(f)), (ii) the midgap energy relative to the O 2p band center (E(O 2p) + (1/2)E(g)), and (iii) atomic electronegativities reproduces calculated E(V) within ∼0.2 eV. This result provides both valuable insights into the key properties influencing E(V) and a direct method to predict E(V). We then predict the E(V) of ∼1800 oxides and validate the predictive nature of our approach against direct defect calculations for a subset of 18 randomly selected materials.
Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway (2008)

Natural cytotoxicity receptors and NKG2D correspond to major activating receptors involved in triggering of tumor cell lysis by human NK cells. In this report, we investigated the expression of NKG2D ligands (NKG2DLs), MHC class I-related chain (MIC) A, MICB and UL16-binding proteins 1, 2 and 3, on a panel of human non-small-cell lung carcinoma cell lines, and we analyzed their role in tumor cell susceptibility to NK cell lysis. Although adenocarcinoma (ADC) cells expressed heterogeneous levels of NKG2DLs, they were often resistant to NK cell-mediated killing. Resistance of a selected cell line, ADC-Coco, to allogeneic polyclonal NK cells and autologous NK cell clones correlated with shedding of NKG2DLs resulting from a matrix metalloproteinase (MMP) production. Treatment of ADC-Coco cells with a MMP inhibitor (MMPI) combined with IL-15 stimulation of autologous NK cell clones lead to a potentiation of NK cell-mediated cytotoxicity. This lysis is mainly NKG2D mediated, since it is abrogated by anti-NKG2D-neutralizing mAb. These results suggest that MMPIs, in combination with IL-15, may be useful for overcoming tumor cell escape from the innate immune response.
A high-efficiency carrier estimator for OFDM communications (1998)

While multipath induced phase rotations can be dealt with by differential encoding in orthogonal frequency division multiplexing (OFDM) communications, the loss of orthogonality due to the carrier offset must be compensated before discrete Fourier transform (DFT)-based demodulation can be performed. In this letter, we present a high-performance/low-complexity blind carrier offset estimation algorithm by exploiting intrinsic structure information of OFDM signals. The algorithm offers the accuracy of a super resolution subspace method, viz. MUSIC, without involving computationally intensive subspace decompositions.
Integration and detection of biochemical assays in digital microfluidic LOC devices (2009)

The ambition of lab-on-a-chip (LOC) systems to achieve chip-level integration of a complete analytical process capable of performing a complex set of biomedical protocols is hindered by the absence of standard fluidic components able to be assembled. As a result, most microfluidic platforms built to date are highly specialized and designed to fulfill the requirements of a single particular application within a limited set of operations. Electrowetting-on-dielectric (EWOD) digital microfluidic technology has been recently introduced as a new methodology in the quest for LOC systems. Herein, unit volume droplets are manipulated along electrode arrays, allowing a microfluidic function to be reduced to a set of basic operations. The highly reprogrammable architecture of these systems can satisfy the needs of a diverse set of biochemical assays and ensure reconfigurability, flexibility and portability between different categories of applications and requirements. While important progress was made over past years in the fabrication, miniaturization and function programming of the basic EWOD fluidic operations, the success of this technology will in great part depend on the ability of researchers to couple or integrate digital microfluidics to detection approaches that can make the system competitive for LOC applications. The detection techniques should be able to circumvent the limitations of hydrophobic surfaces and exploit the advantages of the array format, high droplet transport speeds and rapid mixing schemes. This review provides an in-depth look at recent developments for the coupling and integration of detection techniques with digital microfluidic platforms for bio-chemical applications.
Reactions of ethyl 2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylate (1980)

Reduction, hydrolysis, N-alkylation and N-acylation of 2-(chlorophenyl)-4 H -furo[3,2- b ]pyrrole-5-carboxylate are described. The HMO method was used to calculate compounds I, II, IV and X as model substances furo[3,2- b ]pyrrole, 2-phenylfuro[3,2- b ]pyrrole and methyl furo[3,2- b ]pyrrole-5-carboxylate. The stability and reactivity of the synthesized compounds are discussed on the basis of indexes of chemical reactivity.
EFFICIENCY OF HIERARCHIC AGGLOMERATIVE CLUSTERING USING THE ICL DISTRIBUTED ARRAY PROCESSOR (1989)

The implementation of hierarchic agglomerative methods of cluster anlaysis for large datasets is very demanding of computational resources when implemented on conventional computers. The ICL Distributed Array Processor (DAP) allows many of the scanning and matching operations required in clustering to be carried out in parallel. Experiments are described using the single linkage and Ward's hierarchical agglomerative clustering methods on both real and simulated datasets. Clustering runs on the DAP are compared with the most efficient algorithms currently available implemented on an IBM 3083 BX. The DAP is found to be 2.9–7.9 times as fast as the IBM, the exact degree of speed‐up depending on the size of the dataset, the clustering method, and the serial clustering algorithm that is used. An analysis of the cycle times of the two machines is presented which suggests that further, very substantial speed‐ups could be obtained from array processors of this type if they were to be based on more powerful processing elements.
Occurrence of Cancer Pain (2004)

Occurrence of cancer pain is highly variable and incompletely understood. Surveys are not population-based, are characterized by small heterogeneous samples, and provide sketchy data on etiology of pain, pain syndromes, and clinical or demographic factors. Moreover, the multiple dimensions of pain have not been thoroughly elucidated. Cancer-related pain is caused by the following: 1) direct tumor involvement, 2) diagnostic/therapeutic procedures, and 3) side effects or toxicities of treatment. Individuals may have more than one type of cancer-related pain simultaneously. Occurrence rates range from 14% to 100%, and between 33 and 50% of patients experience pain at some point in the cancer trajectory. Rates are higher (e.g., 70%-100%) in palliative care or pain management settings. Few researchers have focused solely on specific causes of pain in specific patient populations, and only a few included groups at higher risk for pain, such as the elderly or underserved. In general, researchers have not followed pain over time to determine its course, severity, effects on quality of life and functional status, and other related factors. Future researchers should aim to acquire specific information on occurrence of pain in a variety of cancer diagnoses, settings, and groups of people. Longitudinal designs, in-depth exploration of dimensions of pain, and delineation of specific issues in groups such as the elderly, children, and vulnerable populations are essential. Addressing these critical areas will improve our understanding of the occurrence and effects of pain and enhance our ability to provide appropriate interventions, thereby increasing patients' quality of life.
Polyphenoloxidase Activity and Color of Blanched and High Hydrostatic Pressure Treated Banana Puree (1999)

ABSTRACT The effects of blanching and high hydrostatic pressure (HHP) treatments on natural flora evolution, polyphenoloxidase (PPO) activity and color of banana puree adjusted to pH 3.4 and water activity (a w ) of 0.97 were evaluated during 15 days storage at 25°C. Standard plate as well as yeast and mold counts of HHP treated purees were &lt;10 CFU/g throughout storage. Blanching time was found to affect (P&lt;0.05) puree color. HHP treatments retained the initial color of the banana purees. Longer browning induction times and slower browning rates were observed when a longer blanching time was combined with a 689 MPa pressure treatment. A residual PPO activity &lt; 5% was observed in the puree when a 7 min blanch was followed by HHP treatment at 689 MPa for 10 min.
Primate Cardiac Allo- and Xenotransplantation: Modulation of the Immune Response with Photochemotherapy (1989)

Survival of heterotopic allo- and xenografts was studied in a primate cardiac transplantation model. Initially, animals were presensitized to donor xenoantigens by blood transfusion and treated with strategies designed to elicit pretransplant immunosuppression. These animals underwent rapid rejection whether treated with ciclosporin and conventional immunosuppression, autologous sera, sensitized lymphocytes, or photochemotherapy. In a nonsensitized xenograft study, xenografts were maintained for prolonged periods with a combination of ciclosporin and photochemotherapy. All animals treated with photochemotherapy demonstrated periodic suppression of the mixed leukocyte culture response to their donor. Inhibition of lymphocytotoxic antibody was achieved only in animals treated with both ciclosporin and photochemotherapy. Xenosensitized animals were secondarily exposed to donor alloantigens. These animals were successfully allografted. Ciclosporin therapy was terminated and the animals maintained by photochemotherapy alone. This preliminary trial indicates that a combination of ciclosporin and photochemotherapy may be of value in maintaining concordant xenografts and preventing antibody mediated rejection.
Inactivation of the Lysyl Oxidase Gene Lox Leads to Aortic Aneurysms, Cardiovascular Dysfunction, and Perinatal Death in Mice (2002)

Lox has an essential role in the development and function of the cardiovascular system. Inactivation of the Lox gene causes structural alterations in the arterial walls, leading to abnormalities in the cardiovascular functions. Alterations in LOX activity may also play a critical role in certain human cardiovascular diseases.
Possible induction of systemic lupus erythematosus by interferon‐α treatment in a patient with a malignant carcinoid tumour (1990)

Interferon-alpha (IFN-alpha) is currently used in the treatment of various malignant tumours. Development of different autoimmune disorders has been reported in some patients during IFN-alpha therapy. Systemic lupus erythematosus (SLE) after treatment with IFN-alpha has not been described, although a majority of SLE patients have demonstrable serum levels of IFN-alpha, which correlate with disease activity and have been suggested to be of pathogenetic significance. In this paper we describe a patient with a malignant carcinoid tumour who developed a SLE-like syndrome during treatment with leucocyte IFN-alpha. The patient developed myalgia and low grade arthritis in multiple joints together with a high titre of antinuclear antibodies (ANA) and anti-dsDNA antibodies. After the treatment was stopped, the symptoms subsided although a moderate ANA titre persisted. However, the tumour continued to regress despite cessation of IFN-alpha therapy. During a short course with recombinant IFN-alpha the syndrome relapsed, supporting the concept that the SLE syndrome was precipitated by IFN-alpha. A connection between IFN-alpha treatment, the induced autoimmune disorder and regression of the carcinoid tumour is suggested.