gebhart/patrepeval huggingface dataset:
Ascending Auctions with Package Bidding (2002)

Abstract A family of ascending package auction models is introduced in which bidders may determine their own packages on which to bid. In the proxy auction (revelation game) versions, the outcome is a point in the core of the exchange economy for the reported preferences. When payoffs are linear in money and goods are substitutes, sincere reporting constitutes a Nash equilibrium and the outcome coincides with the Vickrey auction outcome. Even when goods are not substitutes, ascending proxy auction equilibria lie in the core with respect to the true preferences. Compared to the Vickrey auction, the proxy auctions generate higher equilibrium revenues, are less vulnerable to shill bidding and collusion, can handle budget constraints much more robustly, and may provide better ex ante investment incentives.
Osteoblast-derived PTHrP is a physiological regulator of bone formation (2005)

Parathyroid hormone-related protein (PTHrP) acts as a paracrine regulator in several tissues, and its physiological roles also extend to bone. In this issue of the JCI, Miao et al. demonstrate that osteoblast-specific ablation of Pthrp in mice results in osteoporosis and impaired bone formation both in vivo and ex vivo. These mice recapitulate the phenotype of mice with haploinsufficiency of Pthrp. The findings demonstrate that PTHrP plays a central role in the physiological regulation of bone formation, by promoting recruitment and survival of osteoblasts, and probably plays a role in the physiological regulation of bone resorption, by enhancing osteoclast formation. This has implications for both our understanding of the pathogenesis of osteoporosis and its treatment.
Isolation and characterization of hepatic cancer cells with stem-like properties from hepatocellular carcinoma. (2010)

The unique characteristics identified in cancer stem cells explain self-renewal and could drive metastasis in patients that have received treatment for cancer. The identification and cloning of such cells can aid in developing of better therapeutic approaches for patients with HCC, as chemosensitive pretherapeutic assays or targeted therapies.
Effects of complement activation in the isolated heart. Role of the terminal complement components. (1992)

The mechanisms of the complement-mediated myocardial injury associated with ischemia and reperfusion have not been elucidated fully. Complement activation may directly mediate injury through actions of the anaphylatoxins C3a and C5a or generation of the membrane attack complex C5b-9. A model was developed to examine the direct effects of complement activation on heart function, assess myocardial tissue damage, and determine which complement components mediate tissue injury. Isolated rabbit hearts were perfused with Krebs-Henseleit buffer by using a modified Langendorff apparatus. Human plasma was added to the perfusate as a source of complement. Rabbit tissue activates human complement. Treatment with 6% normal plasma resulted in complement activation as assessed by the generation of Bb, C3a, C5a, and SC5b-9. Functional changes in cardiac performance became apparent 7-15 minutes after plasma addition and developed fully over the next 20-30 minutes. The effects were dependent on the complement titer and included 1) an increase in the end-diastolic pressure, 2) a decrease in the developed pressure, 3) an increase in the coronary perfusion pressure, and 4) an increase in lymphatic fluid formation. These effects were not elicited when an inhibitor of complement activation (FUT-175) was present or when heat-inactivated plasma was used. The effects of complement activation on myocardial function could not be reproduced by treatment with recombinant human C5a, zymosan-activated plasma, or plasma selectively depleted of C8. Myocardial tissue accumulated sodium and calcium and lost potassium as a result of complement activation. Activation caused the release of creatine kinase from myocytes and an increase in the radiolabeled albumin space of the hearts. The data demonstrate that complement activation caused decrements in myocardial function and increased the coronary perfusion pressure and lymphatic fluid flow rate. The effects were not mediated by the anaphylatoxins but were dependent on the distal complement component C8, suggesting that C5b-9 was responsible for the physiological changes. Complement activation directly mediated tissue injury in a manner consistent with plasmalemmal disruption as a result of C5b-9 formation. The data suggest that the C5b-9 complex, which is known to form under conditions of ischemia, may contribute directly to myocardial cell injury.
Structure-function relationships of antimicrobial peptides (1998)

Antimicrobial peptides are ubiquitously produced throughout nature. Many of these relatively short peptides (6-50 residues) are lethal towards bacteria and fungi, yet they display minimal toxicity towards mammalian cells. All of the peptides are highly cationic and hydrophobic. It is widely believed that they act through nonspecific binding to biological membranes, even though the exact nature of these interactions is presently unclear. High-resolution nuclear magnetic resonance (NMR) has contributed greatly to knowledge in this field, providing insight about peptide structure in aqueous solution, in organic cosolvents, and in micellar systems. Solid-state NMR can provide additional information about peptide-membrane binding. Here we review our current knowledge about the structure of antimicrobial peptides. We also discuss studies pertaining to the mechanism of action. Despite the different three-dimensional structural motifs of the various classes, they all have similar amphiphilic surfaces that are well-suited for membrane binding. Many antimicrobial peptides bind in a membrane-parallel orientation, interacting only with one face of the bilayer. This may be sufficient for antimicrobial action. At higher concentrations, peptides and phospholipids translocate to form multimeric transmembrane channels that seem to contribute to the peptide's hemolytic activity. An understanding of the key features of the secondary and tertiary structures of the antimicrobial peptides and their effects on bactericidal and hemolytic activity can aid the rational design of improved analogs for clinical use.
Pulmonary tuberculosis due to Mycobacterium microti: a study of six recent cases in France (2010)

Human tuberculosis caused by Mycobacterium microti is rare, but its prevalence and clinical significance may have been underestimated. To the best of our knowledge, 21 cases have been reported in the literature in the last decade. We report six recent pulmonary cases caused by M. microti over a period of 5 years detected in French clinical mycobacteriology laboratories of the hospital network. Our data confirm the potential of M. microti to cause clinical illness in immunocompetent patients. M. microti grew slowly from specimens, delaying the final microbiological diagnosis. Therefore, patients with tuberculosis caused by M. microti could benefit from the use of rapid diagnostic molecular techniques directly on clinical samples. From a review of the literature and this study, a classical antituberculous therapy seems effective in treating patients with M. microti disease.
Polystyrene-Dendrimer Amphiphilic Block Copolymers with a Generation-Dependent Aggregation (1995)

A class of amphiphilic macromolecules has been synthesized by combining well-defined polystyrene (PS) with poly(propylene imine) dendrimers. Five different generations, from PS-dendr-NH(2) up to PS-dendr-(NH(2))(32), were prepared in yields of 70 to 90 percent. Dynamic light scattering, conductivity measurements, and transmission electron microscopy show that in aqueous phases, PS-dendr-(NH(2))(32) forms spherical micelles, PS-dendr-(NH(2))(16) forms micellar rods, and PS-dendr-(NH(2))(8) forms vesicular structures. The lower generations of this class of macromolecules show inverted micellar behavior. The observed effect of amphiphile geometry on aggregation behavior is in qualitative agreement with the theory of Israelachvili et al. The amphiphiles presented here are similar in shape but different in size as compared with traditional surfactants, whereas they are similar in size but different in shape as compared with traditional block copolymers.
Platelets stimulate proliferation of bone cells: involvement of platelet‐derived growth factor, microparticles and membranes (2002)

Platelets have been implicated in accelerated bone regeneration in grafting applications. The beneficial effects of platelets may involve their ability to stimulate the proliferation of osteoblasts. We therefore determined the mitogenic response of human trabecular bone-derived cells to human platelets and supernatants of thrombin-activated platelets. We can show a approximately 50-fold increase in DNA-synthesis of bone cells (BC) cultured in the presence of platelets as determined by [3H]-thymidine incorporation. Preventing cell-to-cell contact by a membrane filter did not abrogate the stimulatory effect, indicating the release of soluble factor(s) that are mitogenic for BC. The lipid fraction of the platelets had no effect on [3H]-thymidine uptake into the DNA of BC. Platelet-released supernatant (PRS) increased the rate of [3H]-thymidine incorporation to approximately 20-fold and retained 56% of their activity after incubation at 56 degrees C, and 27% at 100 degrees C, respectively. Neutralizing antibodies raised against platelet-derived growth factor (PDGF) partially suppressed the mitogenic potential of PRS. Gel exclusion chromatography analysis showed that molecules ranging from 25 kDa to more than 70 kDa within the PRS can stimulate BC proliferation. The highest amount of PDGF was detected in fractions corresponding to a molecular weight of 28-37 kDa as determined by immunoassay. The mitogenic activity was not restricted to soluble growth factors because microparticles in the PRS and platelet membranes also increased BC proliferation. Our data indicate that native platelets, the respective PRS, microparticles, and platelet membranes can stimulate the mitogenic activity of BC, thereby contributing to the regeneration of mineralized tissue.
Novel Washpipe-Free ICD Completion With Dissolvable Material (2018)

Abstract Completions using inflow control devices (ICDs) help provide balanced production inflow, delay water and gas breakthrough, and extend the productive life of the well. For fluid circulation, displacement, and wash down, an ICD completion typically utilizes a washpipe or inner string to provide flow to the bottom of the screens. However, the use of a washpipe increases operational time, operational risks, and costs. Through the use of dissolvable materials, a washpipe-free ICD completion has been developed for fluid circulation and wellbore displacement. The dissolution properties of multiple dissolvable materials were experimentally measured with field fluid samples used during running in hole (RIH) and displacement. The degradation rate was characterized at downhole temperatures in terms of both mass loss and volume loss versus time. The dissolvable material was incorporated into a nozzle ICD to help prevent flow between the inner and outer annulus of the tubing. The pressure-holding performance of the ICD with the dissolvable material was measured by means of small-scale testing for pressure integrity, followed by full-scale testing, simulating particular fluid circulation and displacement sequence characteristic of both a Middle East and West Africa application. Laboratory testing was used to determine dissolution rates of multiple materials at representative temperatures and in various fluids. Small-scale testing demonstrated that the dissolvable material provided pressure sealing integrity within the ICD. The dissolution rate of the dissolvable material within the plugged ICD behaved as predicted in the laboratory tests when subjected to circulation and displacement with the fluids representative of the field application. The washpipe-free ICD completion performance tests indicated that the dissolvable material provides a means for circulation and displacement while maintaining pressure integrity necessary for the successful deployment of the lower completion. The capability to run washpipe-free ICD completions helps reduce operational time and costs, and upon dissolution of the dissolvable plugs, delay gas and water breakthrough through the use of ICDs.
PERCUTANEOUS AUTOLOGOUS BONE-MARROW GRAFTING FOR NONUNIONS (2005)

Background: Bone marrow aspirated from the iliac crest contains progenitor cells that can be used to obtain bone-healing of nonunions. However, there is little available information regarding the number and concentration of these cells that are necessary to obtain bone repair. The purpose of this study was to evaluate the number and concentration of progenitor cells that were transplanted for the treatment of nonunion, the callus volume obtained after the transplantation, and the clinical healing rate. Methods: Marrow was aspirated from both anterior iliac crests, concentrated on a cell separator, and then injected into sixty noninfected atrophic nonunions of the tibia. Each nonunion received a relatively constant volume of 20 cm3 of concentrated bone marrow. The number of progenitor cells that was transplanted was estimated by counting the fibroblast colony-forming units. The volume of mineralized bone formation was determined by comparing preoperative computerized tomography scans with scans performed four months following the injection. Results: The aspirates contained an average (and standard deviation) of 612 ± 134 progenitors/cm3 (range, 12 to 1224 progenitors/cm3) before concentration and an average of 2579 ± 1121 progenitors/cm3 (range, 60 to 6120 progenitors/cm3) after concentration. An average total of 51 × 103 fibroblast colony-forming units was injected into each nonunion. Bone union was obtained in fifty-three patients, and the bone marrow that had been injected into the nonunions of those patients contained >1500 progenitors/cm3 and an average total of 54,962 ± 17,431 progenitors. The concentration (634 ± 187 progenitors/cm3) and the total number (19,324 ± 6843) of progenitors injected into the nonunion sites of the seven patients in whom bone union was not obtained were both significantly lower (p = 0.001 and p < 0.01, respectively) than those in the patients who obtained bone union. The volume of the mineralized callus measured at four months on the computerized tomography scans of the patients who had union ranged from 0.8 to 5.3 cm3 (mean, 3.1 cm3). There was a positive correlation between the volume of mineralized callus at four months and the number (p = 0.04) and concentration (p = 0.01) of fibroblast colony-forming units in the graft. There was a negative correlation between the time needed to obtain union and the concentration of fibroblast colony-forming units in the graft (p = 0.04). Conclusions: Percutaneous autologous bone-marrow grafting is an effective and safe method for the treatment of an atrophic tibial diaphyseal nonunion. However, its efficacy appears to be related to the number of progenitors in the graft, and the number of progenitors available in bone marrow aspirated from the iliac crest appears to be less than optimal in the absence of concentration. Level of Evidence: Therapeutic Level III. See Instructions to Authors for a complete description of levels of evidence.
Performance evaluation of a new coding scheme for the peak detecting magnetic recording channel (1991)

A code designed for the magnetic recording channel with peak detection is compared with the industry standard
The Genetics of Alzheimer Disease (1998)

Four genes involved in the development of Alzheimer disease have been identified. Three fully penetrant (deterministic) genes lead to the development of Alzheimer disease in patients younger than 60 years: the amyloid beta-protein precursor on chromosome 21, presenilin 1 on chromosome 14, and presenilin 2 on chromosome 1. Together, they account for about half of this early-onset form of the disease. One genetic risk factor--apolipoprotein E-4--is associated with late-onset Alzheimer disease. It accounts for a substantial fraction of disease burden but seems to act primarily to lower the age of disease onset. In general, none of these genes can be easily adapted for use as a diagnostic or predictive test for Alzheimer disease. Research activity includes searching for additional genes, especially for late-onset disease, and elucidating the mechanism of action of all identified genes as part of a long-term effort to develop more effective therapeutic and preventive strategies.
Non-peptide Antagonists and Agonists of the Bradykinin B2 Receptor (2002)

Stimulation of the bradykinin (BK) B(2) receptor by kinins is associated with pathophysiological as well as pronounced beneficial effects. Consequently, interference with BK B(2) receptors by either antagonism or agonism offers promising therapeutic approaches for the development of drugs for the treatment of various human diseases. BK B(2) receptor antagonists may prove useful for the treatment of pathological situations caused by excessively increased local kinin concentrations, such as inflammation, tissue injury and pain. Beneficial effects of peptide BK B(2) receptor antagonists in perennial rhinitis, asthma and brain edema have already been demonstrated in clinical trials. On the other hand, kinins have also been identified as potent vasodilatory and organ-protective peptides. Therefore, BK B(2) receptor agonists may have the potential to become valuable therapeutics in the treatment of cardiovascular diseases such as hypertension, myocardial hypertrophy, myocardial infarction and arrhythmias as well as diabetic disorders. For both approaches, potent, selective and even orally active non-peptide compounds have been discovered recently. Prototypes of these novel third generation classes of compounds are the alkylphosphonium salt WIN-64338, the pseudopeptide NPC-18884, the thiosemicarbazide bradyzide and especially the imidazo[1,2-a]pyridine FR-167344 and the quinolines FR-173657 and LF-16.0687 as non-peptide BK B(2) receptor antagonists, whereas the 4-(2-pyridylmethoxy)-substituted quinoline FR-190997 and the 3-(2-pyridylmethyl)-substituted benzimidazole FR-191413 emerged as non-peptide BK B(2) receptor agonists. These antagonists and agonists of the BK B(2) receptor have already demonstrated efficacy a various animal models of human diseases, which offers promising therapeutic approaches for the development of drugs for the treatment or even prevention of a variety of severe human diseases either via stimulation or via blockade of BK B(2) receptors.
Grignard reactions to chiral oxazolidine aldehydes (1996)

Modest to high levels of asymmetric induction are observed with Grignard additions to Garner type aldehydes. The resultant secondary alcohols are important precursors of chiral building blocks for asymmetric synthesis and we have demonstrated that they can be readily converted into their respective γ-hydroxy-β-amino alcohols and β-hydroxyamino acids. Additionally, aryloxy ethers, important components of many natural products, can be obtained from these precursors.
Compression of Single-Wall Corrugated Shipping Containers Using Fixed and Floating Test Platens (1992)

Abstract The compression strengths of five different RSC style corrugated fiberboard containers were obtained using both fised and floating compression test platens in order to determine the effect of the platen on the results. The difference between the compression strength using fixed and floating platen methods was found to be small compared to the normal variation in compression strength between identical boxes. It is concluded that either test method is suitable.
Samplernn-Based Neural Vocoder for Statistical Parametric Speech Synthesis (2018)

This paper presents a SampleRNN-based neural vocoder for statistical parametric speech synthesis. This method utilizes a conditional SampleRNN model composed of a hierarchical structure of GRU layers and feed-forward layers to capture long-span dependencies between acoustic features and waveform sequences. Compared with conventional vocoders based on the source-filter model, our proposed vocoder is trained without assumptions derived from the prior knowledge of speech production and is able to provide a better modeling and recovery of phase information. Objective and subjective evaluations are conducted on two corpora. Experimental results suggested that our proposed vocoder can achieve higher quality of synthetic speech than the STRAIGHT vocoder and a WaveNet-based neural vocoder with similar run-time efficiency, no matter natural or predicted acoustic features are used as inputs.
Container-based operating system virtualization (2007)

Hypervisors, popularized by Xen and VMware, are quickly becoming commodity. They are appropriate for many usage scenarios, but there are scenarios that require system virtualization with high degrees of both isolation and efficiency. Examples include HPC clusters, the Grid, hosting centers, and PlanetLab. We present an alternative to hypervisors that is better suited to such scenarios. The approach is a synthesis of prior work on resource containers and security containers applied to general-purpose, time-shared operating systems. Examples of such container-based systems include Solaris 10, Virtuozzo for Linux, and Linux-VServer. As a representative instance of container-based systems, this paper describes the design and implementation of Linux-VServer. In addition, it contrasts the architecture of Linux-VServer with current generations of Xen, and shows how Linux-VServer provides comparable support for isolation and superior system efficiency.
Genetic variability between isolates of human immunodeficiency virus (HIV) type 2 is comparable to the variability among HIV type 1. (1988)

The isolation from macaques of retroviruses related to human immunodeficiency virus (HIV) led to the identification of a second group of human retroviruses (termed HIV-2), which are prevalent in West Africa and closely related to the simian immunodeficiency virus (SIV). We have cloned and determined the complete nucleotide sequence of the human West African retrovirus HIV-2NIH-Z and compared it to that of a previously described strain of HIV-2 (HIV-2ROD) as well as to SIV and HIV-1. We have reached the following conclusions: (i) The HIV-2 isolates are (slightly) more closely related to each other than to SIV, compatible with their isolation from different species. (ii) The variability between HIV-2 isolates is similar in degree and kind to that found among HIV-1 isolates. The equivalent degrees of intragroup divergence suggest that HIV-1 and HIV-2 have existed in their present ranges in Africa for approximately equal lengths of time. The fact that acquired immunodeficiency syndrome is widespread in regions where HIV-1 is prevalent but not in regions where HIV-2 is prevalent suggests a substantial difference in the morbidity rates associated with HIV-1 vs. HIV-2 infection. (iii) HIV-2 and SIV are related to each other more closely than they are to HIV-1.