gebhart/patrepeval huggingface dataset:
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy (2009)

Sanfilippo syndrome type B (mucopolysaccharidosis III B, MPS III B) is an autosomal recessive, neurodegenerative disease of children, characterized by profound mental retardation and dementia. The primary cause is mutation in the NAGLU gene, resulting in deficiency of alpha-N-acetylglucosaminidase and lysosomal accumulation of heparan sulfate. In the mouse model of MPS III B, neurons and microglia display the characteristic vacuolation of lysosomal storage of undegraded substrate, but neurons in the medial entorhinal cortex (MEC) display accumulation of several additional substances. We used whole genome microarray analysis to examine differential gene expression in MEC neurons isolated by laser capture microdissection from Naglu(-/-) and Naglu(+/-) mice. Neurons from the lateral entorhinal cortex (LEC) were used as tissue controls. The highest increase in gene expression (6- to 7-fold between mutant and control) in MEC and LEC neurons was that of Lyzs, which encodes lysozyme, but accumulation of lysozyme protein was seen in MEC neurons only. Because of a report that lysozyme induced the formation of hyperphosphorylated tau (P-tau) in cultured neurons, we searched for P-tau by immunohistochemistry. P-tau was found in MEC of Naglu(-/-) mice, in the same neurons as lysozyme. In older mutant mice, it was also seen in the dentate gyrus, an area important for memory. Electron microscopy of dentate gyrus neurons showed cytoplasmic inclusions of paired helical filaments, P-tau aggregates characteristic of tauopathies-a group of age-related dementias that include Alzheimer disease. Our findings indicate that the Sanfilippo syndrome type B should also be considered a tauopathy.
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study (2019)

Our first-in-humans open-label pilot supports study feasibility and provides initial evidence that senolytics may alleviate physical dysfunction in IPF, warranting evaluation of DQ in larger randomized controlled trials for senescence-related diseases. ClinicalTrials.gov identifier: NCT02874989 (posted 2016-2018).
Compact, low-loss and low-power 8×8 broadband silicon optical switch (2012)

We demonstrated a 8×8 broadband optical switch on silicon for transverse-electrical polarization using a switch-and-selector architecture. The switch has a footprint of only 8 mm × 8 mm, minimum on-chip loss of about 4 dB, and a port-to-port insertion loss variation of only 0.8 dB near some spectral regions. The port-to-port isolation is above 30 dB over the entire 80-nm-wide spectral range or above 45 dB near the central 30 nm. We also demonstrated a switching power of less than 1.5 mW per element and a speed of 2 kHz, and estimated the upper bound of total power consumption to be less than 70 mW even without optimization of the default state of the individual switch elements.
Memorandum of Understanding sebagai Instrumen Hubungan Internasional (2006)

Treaties, used for international relations are : treaty, convention, agreement, pact, statute, covenantmemorandum of understanding, protocol, charter, declaration, final act, arrangement, exchanged of notes, agreed minutes, summary records, process verbal, modus vivendi, accord, and letter of intent. MOU as an instrument of international relations is unique.\nAt first MOUs supplement treaties. Today MOUs are employed in most areas of international relations. MOUs are basically, not legally binding, confidential, convenient, less formal, speedy, and flexible. After all, MOUs should be simultaneously and precisely drafted.\n\nKant Kunci : memorandum of understanding (MO U), huhungan internasional, unik
Obesity and the Risk of Heart Failure (2002)

In our large, community-based sample, increased body-mass index was associated with an increased risk of heart failure. Given the high prevalence of obesity in the United States, strategies to promote optimal body weight may reduce the population burden of heart failure.
Generalised single-phase p-q theory for active power filtering: simulation and DSP-based experimental investigation (2008)

The single-phase p-q theory for the purpose of active power filtering in the case of single-phase loads is dealt with here. A simple modification is proposed to develop a generalised single-phase p-q theory that can be utilised under the condition of distorted utility voltage. A systematic study is presented by realising both direct and indirect current control techniques. The simulation as well as the digital signal processor (DSP) (DS1104 of dSPACE) based experimental results are discussed. The developed single-phase shunt active power filter (APF) prototype is tested under different operating conditions with different loads to evaluate the full capabilities of the proposed generalised theory for practical uses. The shunt APF reduces the source current total harmonics distortion (THD) from 27.2 to 3.4% under a distorted supply voltage with a THD of 16.2%.
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation (2007)

UVB radiation-induced signaling in mammalian cells involves two major pathways: one that is initiated through the generation of DNA photoproducts in the nucleus and a second one that occurs independently of DNA damage and is characterized by cell surface receptor activation. The chromophore for the latter one has been unknown. Here, we report that the UVB response involves tryptophan as a chromophore. We show that through the intracellular generation of photoproducts, such as the arylhydrocarbon receptor (AhR) ligand 6-formylindolo[3,2-b]carbazole, signaling events are initiated, which are transferred to the nucleus and the cell membrane via activation of the cytoplasmatic AhR. Specifically, AhR activation by UVB leads to (i) transcriptional induction of cytochrome P450 1A1 and (ii) EGF receptor internalization with activation of the EGF receptor downstream target ERK1/2 and subsequent induction of cyclooxygenase-2. The role of the AhR in the UVB stress response was confirmed in vivo by studies employing AhR KO mice.
Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy (2006)

Interleukin-12 and interleukin-23 have distinct roles in mediating host defense and autoimmune inflammation. Although targeting interleukin-12 and interleukin-23 simultaneously against the common p40 subunit is efficacious in clinical trials for human autoimmune diseases, targeting of interleukin-23 alone or the downstream effector cytokine interleukin-17A may be an effective treatment strategy for organ-specific autoimmune diseases. It is likely that targeting interleukin-23 or interleukin-17A alone, as opposed to targeting interleukin-12 and interleukin-23 together, will reduce the patients' risk of developing treatment-related infections.
Computation of scattering from clusters of spheres using the fast multipole method (2005)

A T-matrix based method of solution of the multiple scattering problem was presented by the authors [J. Acoust Soc. Am. 112, 2688-2701 (2002)]. This method can be applied to the computation of relatively small problems, since the number of operations required grows with the number of spheres N as O(N3), and with the sixth power of the wave number. The use of iterative techniques accelerated using the fast multipole method (FMM) can accelerate this solution, as presented by Koc and Chew [J. Acoust. Soc. Am. 103, 721-734 (1998)] originally. In this study we present a method that combines preconditioned Krylov subspace iterative techniques, FMM accelerated matrix vector products, a novel FMM-based preconditioner, and fast translation techniques that enable us to achieve an overall algorithm in which the cost of the matrix-vector multiplication grows with N as O (N logN) and with the third power of the wave number. We discuss the convergence of the iterative techniques, selection of the truncation number, errors in the solution, and other issues. The results of the solution of test problems obtained with the method for N approximately 10(2)-10(4) for different wave numbers are presented.
The Rat Aortic Ring Assay for In Vitro Study of Angiogenesis (2003)

Angiogenesis is necessary for growth and metastasis of cancer. It is comprised of several distinct steps, including degradation of extracellular matrix, cell migration, proliferation, and structural reorganization (1). Inhibition of angiogenesis has been shown in pre-clinical studies to suppress tumor growth (2–4). Currently, the use of anti-angiogenic therapy in cancer is under intensive investigation (5). Several in vitro and in vivo assays are available to study angiogenesis, each with its own advantages and limitations (6). In vivo assays simulate the natural process but are often complicated by inflammatory host responses that may interfere with angiogenesis. Variables are more likely to be controlled using in vitro assays. However, these assays are performed using undefined media supplemented with serum, which in itself is very much angiogenic (7). In addition, most in vitro assays are designed only to look at selective phases (endothelial cell migration and proliferation) of angiogenesis.
Guidelines for program content for fellowship training in critical care medicine (1992)

These guidelines have been developed by the Guidelines Committee of the society of Critical Care Medicine, and thereafter reviewed and revised by the Society's Council. These guidelines reflect the official opinion of the society of Critical Care Medicine and do not necessary reflect, and should not be perceived to reflect, the views of certification bodies, regulatory agencies, or other medical review organizations. *Members of the Guidelines Committee who participated in the review and revision of this document include: Carolyn Bekes, MD;, FCCM, Chairman; Margaret Parker, MD;; Ake Grenvik, MD;, FCCM; Dennis Greenbaum, MD;, FCCM; Marilyn Haupt, MD;, FCCM; Bernard Holzman, MD;, FCCM; and H. Mathilda Horst, MD;, FCCM.
Changes in formalin-evoked spinal Fos expression and nociceptive behaviour after oral administration of Bufferin A (aspirin) and L-5409709 (ibuprofen+caffeine+paracetamol) (1997)

This study compares the effects of two non-steroidal anti-inflammatory drugs, Bufferin A (BA) and L-5409709 (L-54), on nociceptive behaviour and spinal Fos expression induced by subcutaneous formalin in the rat. BA contains aspirin. L-54 contains ibuprofen, caffeine and paracetamol. Doses based on the human posology were administered orally 30 or 40 min before subcutaneous intraplantar injection of formalin (1.5%, 50 microl) in the right hindpaw. Low doses (BA, 24 mg/kg; L-54, 21.5 mg/kg) did not significantly affect the behavioural pain response. High doses (BA, 480 mg/kg; L-54, 430 mg/kg) reduced the late phase of the response by 42% and 62% respectively, but did not affect the early phase of the response. No sedative side-effects were observed. The two drugs had different effects on the number of spinal Fos-like immunoreactive neurones 2 h after the formalin injection. Fos expression was reduced after BA treatment, and this reduction was correlated to and matched the reduction of the pain response. In contrast, Fos expression after L-54 treatment was not reduced and was not correlated to the reduction in the pain response. The Fos results reveal clear differences in the way that BA (aspirin) and L-54 (ibuprofen + caffeine + paracetamol) affected transmission of the noxious signal. They suggest that BA did not act beyond the spinal cord and that L-54 had more central sites of action than BA.
H2‐Antihistaminika, 19. Mitt. Synthese und H2‐antihistaminische Wirkung Nα‐substituierter Histamine (1984)

Abstract Es wurden die N α ‐substituierten Histaminderivate 3 und 8a‐d dargestellt und auf ihre H 2 ‐antihistaminische Wirksamkeit untersucht.
Extracting structured information from user queries with semi-supervised conditional random fields (2009)

When search is against structured documents, it is beneficial to extract information from user queries in a format that is consistent with the backend data structure. As one step toward this goal, we study the problem of query tagging which is to assign each query term to a pre-defined category. Our problem could be approached by learning a conditional random field (CRF) model (or other statistical models) in a supervised fashion, but this would require substantial human-annotation effort. In this work, we focus on a semi-supervised learning method for CRFs that utilizes two data sources: (1) a small amount of manually-labeled queries, and (2) a large amount of queries in which some word tokens have derived labels, i.e., label information automatically obtained from additional resources. We present two principled ways of encoding derived label information in a CRF model. Such information is viewed as hard evidence in one setting and as soft evidence in the other. In addition to the general methodology of how to use derived labels in semi-supervised CRFs, we also present a practical method on how to obtain them by leveraging user click data and an in-domain database that contains structured documents. Evaluation on product search queries shows the effectiveness of our approach in improving tagging accuracies.
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. (2002)

The authors' findings indicate that patients with SS-KCS or NS-KCS have conjunctival inflammation manifested by inflammatory cell infiltrates and upregulation of expression in markers of immune activation. Clinical symptoms of KCS may be more dependent on T-cell activation and resultant inflammation than previously believed. In addition to tear substitutes, anti-inflammatory therapeutics should be investigated for the treatment of KCS.
The impact of the addition of naloxone on the use and abuse of pentazocine. (1987)

An epidemic of abuse with "T's and blues" began in the late 1970's in which pentazocine-Talwin tablets ("T")--and the antihistamine tripelennamine (known as blues) were crushed, dissolved together, filtered, and injected intravenously. The resulting high was reported to be similar to that of heroin. In 1981, the manufacturer and the Food and Drug Administration met to discuss a possible solution. As a result, 0.5 mg of naloxone hydrochloride, a narcotic antagonist that is pharmacologically inactive at that dose orally but active if administered parenterally, was added to the tablet formulation. The reformulated product, Talwin Nx, was approved for marketing in late 1982 and introduced in the second quarter of 1983. Distribution of Talwin tablets in the United States was discontinued. The Drug Abuse Warning Network (DAWN) of the National Institute of Drug Abuse and IMS America's National Prescription Audit were used to review the use and abuse patterns of pentazocine before and after the naloxone intervention. The number of prescriptions dispensed quarterly for pentazocine products remained fairly stable from 1981 through the first quarter of 1983 and increased after the introduction of Talwin Nx. In contrast, DAWN emergency room and medical examiner mentions decreased after the product reformulation. The rates of both emergency room and medical examiner mentions per million prescriptions were substantially lower in the 2 years following the introduction of Talwin Nx (decreases of 70 percent by emergency rooms and 71 percent by medical examiners), indicating that the product reformulation successfully reduced pentazocine abuse.
Receptor Tryosine Kinase Inhibitors as Potent Weapons in War Against Cancers (2009)

Receptor Tyrosine Kinases class I (RTK class I, EGF receptor family) constitute a family of transmembrane proteins involved in various aspects of cell growth and survival and have been implicated in the initiation and progression of several types of human malignancies. Activation of EGFR may be because of overexpression, mutations resulting in constitutive activation, or autocrine expression of ligand. In contrast, activation of HER2 occurs mainly by overexpression, which leads to spontaneous homodimerization and activation of downstream signaling events in a ligand-independent manner. EGFR and HER2 have now been validated as a clinically relevant target, and several different types of agents inhibiting these receptors are currently in development. The EGFR inhibitors Erlotinib, Gefitinib, and Cetuximab have undergone extensive clinical testing and have established clinical activity in non small cell lung cancer (NSCLS) and other types of solid tumors. Several of the other erbB inhibitors are also undergoing advanced clinical testing, either alone or in combination with other agents. This review reports various inhibitors, natural, small molecules and monoclonal antibodies, along with their reported activities for various members of erbB family. It will highlight the potential for the development of novel anti-cancer molecules.
Economic growth and equity in the Western Cape (1977)

Over the last few decades the tenet of economic growth has been central to the policies and priorities of most nations and regions of the world. Increasingly however the concept of growth is being questioned. This questioning is primarily the result of a growing realization that growth is creating many problems, the magnitude of which are enormous that in many cases the benefits of growih are not passed on to the mass of the people and that in the quest for economic development, many significant societal and cultural characteristics are being destroyed (Goulet, 1971).
The Common Variant in the FTO Gene Did Not Modify the Effect of Lifestyle Changes on Body Weight: The Finnish Diabetes Prevention Study (2009)

The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity. However, the knowledge of a potential modifying effect of the FTO gene on changes in body weight achieved by lifestyle intervention is limited. We examined whether the FTO gene variant (rs9939609, T/A) is associated with body weight and BMI and long-term weight changes in the Finnish Diabetes Prevention Study (DPS). Altogether, 522 (aged 40-65 years; BMI >or=25 kg/m(2)) subjects with impaired glucose tolerance (IGT) were randomized to control and lifestyle intervention groups. SNP rs9939609 was genotyped from 502 subjects. At baseline, those with the AA genotype had higher BMI than subjects with other genotypes (P = 0.006). The association was observed in women (P = 0.016) but not in men. During the 4-year follow-up, the subjects with the AA genotype had consistently the highest BMI (P = 0.009) in the entire study population. The magnitude of weight reduction was greater in the intervention group, but the risk allele did not modify weight change in either of the groups. Our results confirm the association between the common FTO variant and BMI in a cross-sectional setting and during the long-term lifestyle intervention. We did not observe association between FTO variant and the magnitude of weight reduction achieved by long-term lifestyle intervention. Based on the results from the DPS, it is unlikely that the common variant of the FTO gene affects the success of lifestyle modification on weight loss.
Liver-Expressed Chemokine/CC Chemokine Ligand 16 Attracts Eosinophils by Interacting with Histamine H4 Receptor (2004)

Liver-expressed chemokine (LEC)/CCL16 is a human CC chemokine that is constitutively expressed by the liver parenchymal cells and present in the normal plasma at high concentrations. Previous studies have shown that CCL16 is a low-affinity ligand for CCR1, CCR2, CCR5, and CCR8 and attracts monocytes and T cells. Recently, a novel histamine receptor termed type 4 (H4) has been identified and shown to be selectively expressed by eosinophils and mast cells. In this study, we demonstrated that CCL16 induced pertussis toxin-sensitive calcium mobilization and chemotaxis in murine L1.2 cells expressing H4 but not those expressing histamine receptor type 1 (H1) or type 2 (H2). CCL16 bound to H4 with a K(d) of 17 nM. By RT-PCR, human and mouse eosinophils express H4 but not H3. Accordingly, CCL16 induced efficient migratory responses in human and mouse eosinophils. Furthermore, the responses of human and mouse eosinophils to CCL16 were effectively suppressed by thioperamide, an antagonist for H3 and H4. Intravenous injection of CCL16 into mice induced a rapid mobilization of eosinophils from bone marrow to peripheral blood, which was also suppressed by thioperamide. Collectively, CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils.
Gas Flow Effects on MgO Thin Films Deposited by E-Beam Evaporation Method (2006)

Abstract not Available.
Physiological Roles of Hydrogen Sulfide: Synaptic Modulation, Neuroprotection, and Smooth Muscle Relaxation (2005)

Nearly 300 years have passed since the first description of the toxicity of hydrogen sulfide (H(2)S) in 1713. Although many studies have been devoted to its toxicity, very little attention has been paid to understanding its normal physiological function. Relatively high concentrations of endogenous H(2)S, however, have recently been discovered in animal tissues, and its possible function as a biological messenger has been proposed. H(2)S enhances the activity of N-methyl-D-aspartate receptors and facilitates the induction of hippocampal longterm potentiation, a synaptic model for memory. H(2)S also increases intracellular concentrations of Ca(2+) in glia and induces Ca(2+) waves, which mediate glial signal transmission. Based on accumulating evidence for the reciprocal interactions between glia and neurons, it has been suggested that glia modulate synaptic transmission. Therefore, H(2)S may regulate synaptic activity by modulating the activity of both neurons and glia. In addition to a role in the signal transduction, H(2)S protects neurons from oxidative stress and in smooth muscle it may function as a relaxant. H(2)S, the toxic gas, may therefore be used as a multifunctional signaling mechanism under normal physiological conditions.
Clinical and microbial evaluation of a histatin‐containing mouthrinse in humans with experimental gingivitis (2001)

These data suggest that P-113 mouthrinse is safe and reduces plaque, gingivitis and gingival bleeding in the human experimental gingivitis model.
Collagen-Induced Arthritis as a Model for Rheumatoid Arthritis (2004)

Collagen-induced arthritis (CIA) is an animal model of rheumatoid arthritis (RA) that is widely used to address questions of disease pathogenesis and to validate therapeutic targets. Arthritis is normally induced in mice or rats by immunization with autologous or heterologous type II collagen in adjuvant. Susceptibility to collagen-induced arthritis is strongly associated with major histocompatibility complex class II genes, and the development of arthritis is accompanied by a robust T- and B-cell response to type II collagen. The chief pathological features of CIA include a proliferative synovitis with infiltration of polymorphonuclear and mononuclear cells, pannus formation, cartilage degradation, erosion of bone, and fibrosis. As in RA, pro-inflammatory cytokines, such as tumor necrosis factor alpha(TNFalpha) and interleukin (IL)-1beta, are abundantly expressed in the arthritic joints of mice with CIA, and blockade of these molecules results in a reduction of disease severity.