gebhart/patrepeval huggingface dataset:
Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences andtrans-activate the human growth hormone gene (1990)

Transcription of the human growth hormone (hGH) gene and its regulation are controlled by trans-acting factors that bind to hGH gene promoter sequences. Several DNase I footprints have been described within 500 bp of this promoter, one of which (-289 to -267) has not yet been ascribed to a defined factor. By DNase I footprinting, gel mobility shift, and methylation interference assays with extracts from HeLa cells and GH-producing pituitary tumor (GC) cells, we show that this factor belongs to the NF-I family. When NF-I was competed out of the cell extracts, the trans-acting factor AP-2 bound to the same site as NF-I. AP-2 was present not only in HeLa cells, but also in GC cells albeit at a much lower concentration. Consistent with the mutually exclusive binding of NF-I and AP-2, their methylation interference patterns included four guanine residues that were crucial for binding of both NF-I and AP-2. Cell-free transcription from the hGH gene promoter showed that these two factors can transactivate this gene.
Intractable mycobacterial infections associated with genetic defects in the receptor for interferon gamma: what does this tell us about immunity to mycobacteria? (1997)

The attenuated strain of Mycobacterium bovis bacille Calmette-Gue rin (BCG) is the most widely used vaccine in the world. In most children, inoculation of live BCG vaccine is harmless although it occasionally leads to a benign regional adenitis. In rare cases, however, vaccination causes disseminated BCG infection, which may be lethal. Impaired immunity of the host is generally thought to be the pathogenic mechanism. Disseminated BCG infection has been reported in children with inherited immune disorders. Most of these children had severe combined immunodeficiency, which is characterized by an absence of T cells, and some had chronic granulomatous disease, which is marked by an impairment of the phagocyte respiratory burst. Rare cases of BCG infection have also been reported in association with the acquired immunodeficiency syndrome. We examined the five genes coding for interferon-, interferon-R1, IRF1, TNF-, and TNF-R1 in a child with fatal idiopathic disseminated BCG infection. We found a mutation of the gene for interferon-R1. There was no detectable interferon-R1 on the cells from the affected child. These findings provide further evidence of the importance of interferonin the response to mycobacterial infection.
Plant hemoglobins: Important players at the crossroads between oxygen and nitric oxide (2011)

Plant hemoglobins constitute a diverse group of hemeproteins and evolutionarily belong to three different classes. Class 1 hemoglobins possess an extremely high affinity to oxygen and their main function consists in scavenging of nitric oxide (NO) at very low oxygen levels. Class 2 hemoglobins have a lower oxygen affinity and they facilitate oxygen supply to developing tissues. Symbiotic hemoglobins in nodules have mostly evolved from class 2 hemoglobins. Class 3 hemoglobins are truncated and represent a clade with a very low similarity to class 1 and 2 hemoglobins. They may regulate oxygen delivery at high O(2) concentrations. Depending on their physical properties, hemoglobins belong either to hexacoordinate non-symbiotic or pentacoordinate symbiotic groups. Plant hemoglobins are plausible targets for improving resistance to multiple stresses.
The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD) (2017)

COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its' progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this.
[Single nucleotide polymorphisms of the DGKK gene and hypospadias in Chinese children]. (2014)

The polymorphisms of the DGKK gene may be associated with hypospadias, particularly distal and middle hypospadias, in Chinese children.
Manipulation of the helper T cell response to influence antigenic competition occurring with a multivalent vaccine (1996)

The reduction in antibody observed following inoculation with multiple heterologous Dichelobacter nodosus pili antigens is thought to be due to competition between antigen-specific B cells for a limited amount of T cell help. We demonstrate here that this competition is not further influenced by the expansion of cross-reactive antibody secreting cells at the expense of serogroup specific antibody secreting cells. The T cell determinants of pili recognized by sheep and BALB/c mice have been defined using 15 residue peptides. These T cell determinants include cross-reactive determinants in the conserved amino terminal region of the antigen. Here we investigate the effect of expanding the pili-specific T cell population by priming with pili derived T cell determinants. It was not possible to increase the antibody elicited in response to the multivalent vaccine by priming mice with either a synthetic peptide spanning a T cell determinant or with reduced and alkylated or heterologous serogroups of pili 4 weeks before inoculation with the multivalent vaccine. A strategy designed to increase the T cell population by inoculating animals with pili covalently coupled to an extrinsic T cell determinant was pursued.
Is the Price of Victory Just: Attorney's Fees, Punitive Damages, and the Future of Title IX in Mercer v. Duke University (2006)

Title IX of the Education Amendments of 1972 ("Title IX") has been one of the most controversial topics in America since its inception.'Both lauded and despised, Title IX's enactment introduced major ramifications for athletic programs falling within its jurisdiction, including colleges and universities receiving funds from the federal government. 2Throughout the United States, many colleges and universities faced the need to make institutional changes in their athletic programs after realizing they were not in compliance with the statute's regulations. 3Litigation under Title IX' forced the judiciary to clarify the contours of Title IX's ambiguous provisions, a process that continues to this day. 41.
c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays (2007)

Inflammatory breast carcinoma (IBC) is a rare but aggressive tumour associated with poor outcome owing to early metastases. Increased expression of c-Met protein correlates with reduced survival and high metastatic risk in human cancers including breast carcinomas and is targetable by specific drugs, that could potentially improve the prognosis. In the present study, we compared c-Met expression in IBC (n=41) and non-IBC (n=480) immunohistochemically (Ventana Benchmark autostainer) in two tissue microarrays (TMA) along with PI3K and E-cadherin. The results were quantified through an automated image analysis device (SAMBA Technologies). We observed that (i) c-Met was significantly overexpressed in IBC as compared with non-IBC (P<0.001), (ii) PI3K was overexpressed (P<0.001) in IBC, suggesting that the overexpressed c-Met is functionally active at least through the PI3K signal transduction pathway; and (iii) E-cadherin was paradoxically also overexpressed in IBC. We concluded that overexpressed c-Met in IBC constitutes a potential target for specific therapy for the management of patients with poor-outcome tumours such as IBC. Automated image analysis of TMA proved to be a valuable tool for high-throughput immunohistochemical quantification of the expression of intratumorous protein markers.
Laser scanning cytometry for the detection of neoplasia in urologic cytology specimens (2004)

The authors determined that DNA ploidy analysis of atypical urologic cytology specimens using LSC is a useful adjunct tool for identifying malignant specimens that lack sufficient cytologic criteria for diagnosis by light microscopy alone. However, LSC is time consuming and requires expensive equipment.
Comparative genomics study of inverted repeats in bacteria (2002)

http://lagash.dft.unipa.it/IR.html
Calibration of Pan-Tilt-Zoom (PTZ) Cameras and Omni-Directional Cameras (2005)

In the first part we discuss the problem of recovering the calibration of a network of pan-tilt-zoom cameras. The intrinsic parameters of each camera over its full range of zoom settings are estimated through a two step procedure. We first determine the intrinsic parameters at the camera's lowest zoom setting very accurately by capturing an extended panorama. The camera intrinsics are then determined at discrete steps in a monotonically increasing zoom sequence that spans the full zoom range of the cameras. Both steps are fully automatic and do not assume any knowledge of the scene structure. We validate our approach by calibrating two different types of pan tilt zoom cameras placed in an outdoor environment. We also show the high-resolution panoramic mosaics built from the images captured during this process. The second section deals with the calibration of omnidirectional cameras. A broad class of both central and non-central cameras, such as fish-eye and catadioptric cameras, can be reduced to 1D radial cameras under the assumption of known center of radial distortion. We study the multi-view geometry of 1D radial cameras. For cameras in general configuration, we introduce a quadrifocal tensor. From this tensor a metric reconstruction of the 1D cameras as well as the observed features can be obtained. In a second phase this reconstruction can then be used as a calibration object to estimate a non-parametric non-central model for the cameras. We study some degenerate cases, including pure rotation. In the case of a purely rotating camera we obtain a trifocal tensor. This allows us to obtain a metric reconstruction of the plane at infinity. Next, we use the plane at infinity as a calibration device to non-parametrically estimate the radial distortion.
The Enzymatic Hydroxylation of n-Octane by Corynebacterium sp. Strain 7E1C (1970)

Abstract Cell-free extracts from sonically disrupted Corynebacterium sp. (7E1C) oxidized n-octane to 1-octanol and octanoic acid in the presence of NADH and O2. The hydroxylating activity, assayed by direct estimation of the reaction products, was found to be concentrated in the clarified S3 suprenatant fraction after centrifugation at 144,000 x g for 2 hours. By use of mass spectrometry it was shown that molecular oxygen is incorporated into the substrate during hydroxylation. The hydroxylating enzyme system was separated into two protein fractions, both of which were required for activity. One fraction, the S3(25–40)D, which precipitated between 25 and 40% ammonium sulfate saturation, appeared particulate and contained cytochrome P-450. The participation of this hemoprotein in n-octane hydroxylation was established by inhibition, induction, and spectral studies. The S3(60–100)D fraction, which precipitated between 60 and 100% ammonium sulfate saturation, was soluble, contained flavoprotein, and was functional in reducing cytochrome P-450 or cytochrome c in the presence of NADH. A tentative scheme for n-octane hydroxylation in the Corynebacterium 7E1C system is proposed.
Evidence for a novel function of the CD40 ligand as a signalling molecule in T‐lymphocytes (1997)

The interaction of the CD40 receptor with its ligand has been shown to be crucial for the activation of B-lymphocytes. Here, we provide evidence that the pg39 molecule/CD40 ligand (gp39/CD40L) also functions as a stimulatory molecule for T-lymphocytes. Activation of T-lymphocytes via gp39/CD40L induced a strong activation of Jun-N-terminal kinase (JNK) and p38-K. Activation of these kinases correlates with a stimulation of Rac1 and inhibition of Rac1 prevents gp39/CD40L triggered JNK/p38-K activation. Further, cellular stimulation via the CD40 ligand results in tyrosine phosphorylation of cellular proteins and the activation of p56(lck). Inhibition of src-like kinases inhibits Rac1 as well as JNK/p38-K stimulation suggesting a signalling cascade from the gp39/CD40L via p56(lck) and Rac1 to JNK/p38-K.
Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3 (2000)

Older men with vertex balding have lower circulating levels of IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors (2007)

In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] subunits, linking them to downstream neurotoxic signaling molecules. Perturbing NMDAR/PSD-95 interactions with a Tat peptide comprising the nine C-terminal residues of the NR2B subunit (Tat-NR2B9c) reduces neurons' vulnerability to excitotoxicity and ischemia. However, NR subunit C termini may bind many of >240 cellular PDZs, any of which could mediate neurotoxic signaling independently of PSD-95. Here, we performed a proteomic and biochemical analysis of the interactions of all known human PDZs with synaptic signaling proteins including NR1, NR2A-NR2D, and neuronal nitric oxide synthase (nNOS). Tat-NR2B9c, whose interactions define PDZs involved in neurotoxic signaling, was also used. NR2A-NR2D subunits and Tat-NR2B9c had similar, highly specific, PDZ protein interactions, of which the strongest were with the PSD-95 family members (PSD-95, PSD-93, SAP97, and SAP102) and Tax interaction protein 1 (TIP1). The PSD-95 PDZ2 domain bound NR2A-NR2C subunits most strongly (EC50, approximately 1 microM), and fusing the NR2B C terminus to Tat enhanced its affinity for PSD-95 PDZ2 by >100-fold (EC50, approximately 7 nM). IC50 values for Tat-NR2B9c inhibiting NR2A-NR2C/PSD-95 interactions (approximately 1-10 microM) and nNOS/PSD-95 interactions (200 nM) confirmed the feasibility of such inhibition. To determine which of the PDZ interactions of Tat-NR2B9c mediate neuroprotection, one of PSD-95, PSD-93, SAP97, SAP102, TIP1, or nNOS expression was inhibited in cortical neurons exposed to NMDA toxicity. Only neurons lacking PSD-95 or nNOS but not PSD-93, SAP97, SAP102, or TIP1 exhibited reduced excitotoxic vulnerability. Thus, despite the ubiquitousness of PDZ domain-containing proteins, PSD-95 and nNOS above any other PDZ proteins are keys in effecting NMDAR-dependent excitotoxicity. Consequently, PSD-95 inhibition may constitute a highly specific strategy for treating excitotoxic disorders.
Pancreatic cancer among workers processing synthetic resins (1995)

A nested case-control study was conducted to investigate whether an excess of pancreatic cancer, identified in a cohort mortality study with follow-up from 1946 through 1988, was associated with potential workplace exposures at a New Jersey plastics manufacturing and research and development facility. The study population included 28 male pancreatic cancer cases and 140 randomly selected controls, matched on year of birth and at risk (alive) at the time of the case death. Using plant work history records, department assignments for the two groups were compared according to duration and time since first assignment. Workers assigned to a work area that processed vinyl resins and polyethylene (PE) were shown to be at increased risk. Men assigned more than 16 years to this department had a significantly increased risk ratio of 7.15 (95% confidence intervals [CI]: 1.28-40.1). No excess was seen with shorter duration assignments. Seven of the nine cases began working in this area in the 1940s. Average latency was 32 years, and all but three cases worked 20 years or more in this unit. Over the study period, significant exposure-related process changes occurred, in addition to the use of numerous chemical additives. Although vinyl and PE processing operations could not be analyzed separately, the pancreatic cancer excess is more likely to be related to vinyl processing. Identification of a causative agent or combination of agents would require investigations with more detailed exposure information.
On-line Algorithms in Machine Learning. (1996)

. The areas of On-Line Algorithms and Machine Learning are both concerned with problems of making decisions about the present based only on knowledge of the past. Although these areas differ in terms of their emphasis and the problems typically studied, there are a collection of results in Computational Learning Theory that fit nicely into the &amp;quot;on-line algorithms&amp;quot; framework. This survey article discusses some of the results, models, and open problems from Computational Learning Theory that seem particularly interesting from the point of view of on-line algorithms. The emphasis in this article is on describing some of the simpler, more intuitive results, whose proofs can be given in their entirity. Pointers to the literature are given for more sophisticated versions of these algorithms. 1 Introduction The areas of On-Line Algorithms and Machine Learning are both concerned with problems of making decisions from limited information. Although they differ in terms of their emphasis and the...
Design of the CCD Color Selector (2009)

The color selector is the quick food selection equipment integrating many high technologies such as optics, machine and electrics, and it is mainly used to separate heterochromous grains such as yellowing grains, mildew grains and impurities from rice, peanuts, melon seeds and sesames, and it is the important equipment to ensure the safety and quality of grains. In this article, the design principle and the composing parts of the CCD color selector are simply introduced. The color selector includes the main control system, the checking separation system, the vibration feed-in system and the optical system. The main control system mainly controls and manages various subsystems, and harmonizes exterior functional modules. The checking separation system mainly selects and eliminates the heterochromous grains checked by the optimal system. The vibration feed-in system is used to control the flux of materials. The optical system is mainly composed by the optical illumination system and the optical imaging system, and it is the core part of the color selector.
The transcription factor ATF5: role in cellular differentiation, stress responses, and cancer (2017)

Activating transcription factor 5 (ATF5) is a cellular prosurvival transcription factor within the basic leucine zipper (bZip) family that is involved in cellular differentiation and promotes cellular adaptation to stress. Recent studies have characterized the oncogenic role of ATF5 in the development of several different types of cancer, notably glioblastoma. Preclinical assessment of a systemically deliverable dominant-negative ATF5 (dnATF5) biologic has found that targeting ATF5 results in tumor regression and tumor growth inhibition of glioblastoma xenografts in mouse models. In this review, we comprehensively and critically detail the current scientific literature on ATF5 in the context of cellular differentiation, survival, and response to stressors in normal tissues. Furthermore, we will discuss how the prosurvival role of ATF5 aides in cancer development, followed by current advances in targeting ATF5 using dominant-negative biologics, and perspectives on future research.
Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes (1997)

Recently, a murine scavenger receptor type B class I (SR-BI) was identified that binds high density lipoprotein (HDL) and mediates the selective uptake of cholesterol esters. The human CD36 and LIMPII analogous-1 (CLA-1) receptor shows high sequence homology with SR-BI, but their functional relationship has not been determined. Transfected cells expressing CLA-1 bound HDL with a Kd of about 35 microg/ml, similar to the Kd for HDL binding to rodent SR-BI. This binding resulted in an intracellular accumulation of HDL-derived [3H]cholesterol esters without internalization or degradation of 125I-apolipoprotein. CLA-1 was strongly expressed in the adrenal gland and was also abundant in liver and testis, suggesting that CLA-1, like SR-BI, could play a role in the metabolism of HDL. However, CLA-1 was also expressed in monocytes and, like SR-BI, recognized modified forms of low density lipoproteins as well as native LDL and anionic phospholipids. These findings suggest that CLA-1 might have additional physiological functions. We found that CLA-1 recognizes apoptotic thymocytes. Our results demonstrate that CLA-1, a close structural homologue of SR-BI, is also functionally related to SR-BI and may play an important role as a "docking receptor" for HDL in connection with selective uptake of cholesterol esters. An additional role in recognition of damaged cells is suggested by these studies.
Marked inhibition of glioblastoma target cell tumorigenicity in vitro by retrovirus-mediated transfer of a hairpin ribozyme against deletion-mutant epidermal growth factor messenger RNA (2000)

These findings indicate that the anti-deltaEGFR-sCYMV1 hairpin ribozyme is capable of specifically inhibiting the expression of deltaEGFR and reversing the deltaEGFR-associated malignant phenotype of GBM cells. This strategy may constitute a promising gene therapy approach for a molecularly defined subgroup of GBMs.
Solar Energy Supply and Storage for the Legacy and Nonlegacy Worlds (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSolar Energy Supply and Storage for the Legacy and Nonlegacy WorldsTimothy R. Cook, Dilek K. Dogutan, Steven Y. Reece, Yogesh Surendranath, Thomas S. Teets, and Daniel G. Nocera*View Author Information Department of Chemistry, 6-335, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307, United States* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Chem. Rev. 2010, 110, 11, 6474–6502Publication Date (Web):November 10, 2010Publication History Received2 August 2010Published online10 November 2010Published inissue 10 November 2010https://pubs.acs.org/doi/10.1021/cr100246chttps://doi.org/10.1021/cr100246creview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views32426Altmetric-Citations2664LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Batteries,Catalysts,Electrodes,Energy storage,Solar energy Get e-Alerts