gebhart/patrepeval huggingface dataset:
A Nuclear Magnetic Resonance Study of Aqueous Pyruvate-Glycinate-Zinc(II) and Related Systems (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Nuclear Magnetic Resonance Study of Aqueous Pyruvate-Glycinate-Zinc(II) and Related SystemsD. Leussing and Carol K. StanfieldCite this: J. Am. Chem. Soc. 1964, 86, 14, 2805–2810Publication Date (Print):July 1, 1964Publication History Published online1 May 2002Published inissue 1 July 1964https://pubs.acs.org/doi/10.1021/ja01068a011https://doi.org/10.1021/ja01068a011research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Performance debugging for distributed systems of black boxes (2003)

Many interesting large-scale systems are distributed systems of multiple communicating components. Such systems can be very hard to debug, especially when they exhibit poor performance. The problem becomes much harder when systems are composed of "black-box" components: software from many different (perhaps competing) vendors, usually without source code available. Typical solutions-provider employees are not always skilled or experienced enough to debug these systems efficiently. Our goal is to design tools that enable modestly-skilled programmers (and experts, too) to isolate performance bottlenecks in distributed systems composed of black-box nodes.We approach this problem by obtaining message-level traces of system activity, as passively as possible and without any knowledge of node internals or message semantics. We have developed two very different algorithms for inferring the dominant causal paths through a distributed system from these traces. One uses timing information from RPC messages to infer inter-call causality; the other uses signal-processing techniques. Our algorithms can ascribe delay to specific nodes on specific causal paths. Unlike previous approaches to similar problems, our approach requires no modifications to applications, middleware, or messages.
A data management model for change control in collaborative design environments (1996)

This thesis presents a data management model to support collaborative design environments. Specifically, the proposed model describes a multidisciplinary project in terms of independently evolving designs from the participating disciplines. The model monitors independent design activities by systematically tracking component descriptions in the individual disciplines. Projects are coordinated through asynchronous communication of design changes. There are two salient features of the given model. First, we specify a three-layered closely coupled framework of versions, assemblies, and configurations. In this framework, configurations integrate designs from each of the participating disciplines to describe an overall project. Assemblies can be either total or partial. The designs in each discipline are represented as total assemblies; partial assemblies represent complex entities that can be further aggregated to describe an overall design in a given discipline. Complex entities are in turn formed by aggregating instances of primitive entities in the database. We maintain an evolving description of a primitive entity as a version hierarchy; each version in a given hierarchy contains specific descriptions of instances of that entity.
The second feature introduces a new concept, equivalent operation, which provides an efficient mechanism for managing changes among versions of a primitive entity. Intuitively, an equivalent operation is a single data operation that summarizes the effect of a sequence of changes on an instance description. By applying this concept, we establish a version of a primitive entity as the summary of all changes that have been made to its contents. A version in the data management model is thus a unit of granularity whose consistency can be evaluated. In addition, we develop operators to store, detect and characterize changes among individual versions. The close coupling of the version, assembly and configuration levels allows these computed version changes to be recursively combined to represent changes at various assembly and configuration levels.
Applying these two concepts, the model efficiently supports project coordination through the asynchronous communication of changes among designers, as well as project monitoring through the systematic tracking of evolving project descriptions. We have implemented and tested the model in both an ORACLE relational database for alpha-numeric design data as well as an AUTOCAD environment for 3-D graphical objects.
Activation of microglia: A neuroinflammatory role for CAP37 (2002)

Recent evidence suggests that inflammation and immune function in the central nervous system (CNS) may play a considerable role in the progression of many neurodegenerative diseases. It is known that microglia, the CNS equivalent of peripheral blood monocytes, may be instrumental in causing neurotoxicity. However, the mediator(s) that activates microglia to produce toxic substances that orchestrate cell death has yet to be elucidated. We have identified a novel inflammatory molecule, cationic antimicrobial protein of molecular weight 37 kDa (CAP37), to the brains of patients dying from Alzheimer's disease. CAP37 is known to be a potent activator and regulator of monocyte function in the systemic circulation. We hypothesize that CAP37, a mediator previously shown to recruit and activate monocytes in the systemic circulation, may also play a role in CNS inflammation by modulating microglial function. Here we demonstrate that CAP37 is a chemoattractant for microglia and that CAP37-treated microglia express class II major histocompatibility antigens and produce proinflammatory cytokines and chemokines. We conclude that CAP37 has the ability to activate microglial cells and suggest that it has the potential to serve as a neuroinflammatory molecule.
Alefacept for the treatment of psoriasis and other dermatologic diseases (2007)

Alefacept is a novel biologic agent for the treatment of plaque psoriasis. Alefacept is a fully human recombinant dimeric fusion protein composed of the terminal portion of Leukocyte Functioning Antigen-3 (LFA-3) and the Fc portion of human IgG(1). The drug likely works in part by inducing the apoptosis of memory effector (activated) T cells that play a central role in the pathophysiology of psoriasis. Alefacept also may interrupt the direct immunologic activation of T cells by antigen presenting cells. Alefacept is administered as a course of 12 intramuscular injections, but other dosing strategies have been explored. After a course of therapy, statistically more patients receiving alefacept achieve a psoriasis area and severity index (PASI) 75 response than those receiving a placebo. Some patients who achieve PASI 75 also experience long-term remissions from psoriasis. The drug is well-tolerated and adverse events are rare. Off-label use of the drug is growing and may be formally explored in the future.
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance† (2008)

JNK1 and JNK2 both mediate insulin resistance in HFD-fed mice, but the JNK isoforms have distinct effects on steatohepatitis, with JNK1 promoting steatosis and hepatitis and JNK2 inhibiting hepatocyte cell death by blocking the mitochondrial death pathway.
GGDEF domain is homologous to adenylyl cyclase (2000)

The GGDEF domain is detected in many prokaryotic proteins, most of which are of unknown function. Several bacteria carry 12-22 different GGDEF homologues in their genomes. Conducting extensive profile-based searches, we detect statistically supported sequence similarity between GGDEF domain and adenylyl cyclase catalytic domain. From this homology, we deduce that the prokaryotic GGDEF domain is a regulatory enzyme involved in nucleotide cyclization, with the fold similar to that of the eukaryotic cyclase catalytic domain. This prediction correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Domain architecture analysis shows that GGDEF is typically present in multidomain proteins containing regulatory domains of signaling pathways or protein-protein interaction modules. Evolutionary tree analysis indicates that GGDEF/cyclase superfamily forms a large diversified cluster of orthologous proteins present in bacteria, archaea, and eukaryotes. Proteins 2001;42:210-216.
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination. (1991)

The chemopreventive action of 40 and 80% maximum tolerated dose (MTD) levels of piroxicam, D,L-alpha-difluoromethylornithine (DMFO), 16 alpha-fluoro-5-androsten-17-one (DHEA analogue 8354), and ellagic acid (EA) administered in diet individually and in combination before and during initiation and postinitiation phases of azoxymethane-induced neoplasia of the intestine was studied in male F344 rats. The MTD levels of piroxicam, DFMO, DHEA analogue, and EA were determined in male F344 rats and found to be 500, 5,000, 500, and 10,000 ppm, respectively, in modified AIN-76A diet. When these agents were fed in combination, the MTD levels were: piroxicam plus DFMO, 250 and 2500 ppm; piroxicam plus DHEA analogue, 250 and 250 ppm; piroxicam plus EA, 250 and 5000 ppm; piroxicam plus DFMO plus DHEA analogue, 250, 2500, and 250 ppm; and piroxicam plus DFMO plus EA, 250, 2500, and 5000 ppm. From these MTD values, 40 and 80% MTD levels were calculated and tested for their efficacy. At 5 weeks of age, animals were fed the modified AIN-76A (control) diet and experimental diets containing 40 and 80% MTD levels of piroxicam, DFMO, DHEA analogue, and EA individually and in combination. At 7 weeks of age, all animals except the vehicle-treated groups were administrated s.c. injections of azoxymethane (15 mg/kg body weight/week for 2 weeks). Animals intended for vehicle treatment received s.c. injections of an equal volume of normal saline. Fifty-two weeks after azoxymethane and saline treatment all the animals were necropsied, and colon and small intestinal tumor incidence (percentage of animals with tumors) and multiplicity (tumors/animal) were compared among various dietary groups. The results indicate that 40 and 80% MTD levels of dietary piroxicam and DFMO significantly (P less than 0.001) inhibited colon and small intestinal tumor incidence and multiplicity. DHEA analogue at 40% MTD level significantly decreased the small intestinal and colon tumor incidences (P less than 0.05), whereas 80% MTD of DHEA analogue inhibited only small intestinal tumor incidence. EA at 40 and 80% MTDs had no significant effect on colon tumor incidence (P greater than 0.05), but 80% MTD of EA showed a significant inhibitory effect on the incidence of small intestinal adenocarcinomas (P less than 0.01). In the combination study, 40 and 80% MTD levels of piroxicam plus DFMO significantly (P less than 0.001) inhibited colon adenocarcinoma incidence (8.3%) and multiplicity (0.08 +/- 0.04) (SE) when compared to colon adenocarcinoma incidence (72.2%) and multiplicity (1.14 +/- 0.18) in control diet-fed animals.(ABSTRACT TRUNCATED AT 400 WORDS)
Longer Leukocyte Telomere Length Is Associated with Smaller Hippocampal Volume among Non-Demented APOE ε3/ε3 Subjects (2012)

Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ε4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ε3/ε3 carriers; 28 ε4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s) = -0.465; p = 0.011), right (r(s) = -0.414; p = 0.025), and total hippocampus volume (r(s) = -0.519; p = 0.004) among APOE ε3/ε3 carriers, but not among ε4 carriers. However, the ε4 carriers fit with the general correlation pattern exhibited by the ε3/ε3 carriers, as ε4 carriers on average had longer telomeres and smaller hippocampi compared with ε3/ε3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.
Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism (2012)

Circular dichroism (CD) spectroscopy is an optical technique that measures the difference in the absorption of left and right circularly polarized light. This technique has been widely employed in the studies of nucleic acids structures and the use of it to monitor conformational polymorphism of DNA has grown tremendously in the past few decades. DNA may undergo conformational changes to B-form, A-form, Z-form, quadruplexes, triplexes and other structures as a result of the binding process to different compounds. Here we review the recent CD spectroscopic studies of the induction of DNA conformational changes by different ligands, which includes metal derivative complex of aureolic family drugs, actinomycin D, neomycin, cisplatin, and polyamine. It is clear that CD spectroscopy is extremely sensitive and relatively inexpensive, as compared with other techniques. These studies show that CD spectroscopy is a powerful technique to monitor DNA conformational changes resulting from drug binding and also shows its potential to be a drug-screening platform in the future.
Transduction of envelope stress in Escherichia coli by the Cpx two-component system (1997)

Disruption of normal protein trafficking in the Escherichia coli cell envelope (inner membrane, periplasm, outer membrane) can activate two parallel, but distinct, signal transduction pathways. This activation stimulates the expression of a number of genes whose products function to fold or degrade the mislocalized proteins. One of these signal transduction pathways is a two-component regulatory system comprised of the histidine kinase CpxA and the response regulator, CpxR. In this study we characterized gain-of-function Cpx* mutants in order to learn more about Cpx signal transduction. Sequencing demonstrated that the cpx* mutations cluster in either the periplasmic, the transmembrane, or the H-box domain of CpxA. Intriguingly, most of the periplasmic cpx* gain-of-function mutations cluster in the central region of this domain, and one encodes a deletion of 32 amino acids. Strains harboring these mutations are rendered insensitive to a normally activating signal. In vivo and in vitro characterization of maltose-binding-protein fusions between the wild-type CpxA and a representative cpx* mutant, CpxA101, showed that the mutant CpxA is altered in phosphotransfer reactions with CpxR. Specifically, while both CpxA and CpxA101 function as autokinases and CpxR kinases, CpxA101 is devoid of a CpxR-P phosphatase activity normally present in the wild-type protein. Taken together, the data support a model for Cpx-mediated signal transduction in which the kinase/phosphatase ratio is elevated by stress. Further, the sequence and phenotypes of periplasmic cpx* mutations suggest that interactions with a periplasmic signaling molecule may normally dictate a decreased kinase/phosphatase ratio under nonstress conditions.
Testing Cylindrical Lenses (1987)

Two new techniques for testing cylindrical lenses are discussed and compared. One makes use of an optical fiber as a cylindrical reference; the other utilizes diffraction through a slit.
Integrating UML diagrams for production control systems (2000)

This paper proposes to use SDL block diagrams, UML class diagrams, and UML behavior diagrams like collaboration diagrams, activity diagrams, and statecharts as a visual programming language. We describe a modeling approach for flexible, autonomous production agents, which are used for the decentralization of production control systems. In order to generate a (Java) implementation of a production control system from its specification, we define a precise semantics for the diagrams and we define how different (kinds of) diagrams are combined to a complete executable specification.
Communication complexity of secure computation (extended abstract) (1992)

A secret-ballot vote for a single proposition is an example of a secure distributed computation. The goal is for m participants to jointly compute the output of some n-ary function (in this case, the sum of the votes), while protecting their individual inputs against some form of misbehavior.
An Analysis of the Accuracy of Bluetooth Low Energy for Indoor Positioning Applications (2014)

This study investigated the impact of Bluetooth Low Energy devices in advertising/beaconing mode on fingerprint-based indoor positioning schemes. Early experimentation demonstrated that the low bandwidth of BLE signals compared to WiFi is the cause of significant measurement error when coupled with the use of three BLE advertising channels. The physics underlying this behaviour is verified in simulation. A multipath mitigation scheme is proposed and tested. It is determined that the optimal positioning performance is provided by 10Hz beaconing and a 1 second multipath mitigation processing window size. It is determined that a steady increase in positioning performance with fingerprint size occurs up to 7 ±1, above this there is no clear benefit to extra beacon coverage.
Stresses and deformation processes in thin films on substrates (1988)

Abstract The stresses that develop in thin films on substrates can be detrimental to the reliability of thin film electronic devices. In order to design these devices for improved mechanical reliability, an understanding of the origin of these stresses and the controlling deformation processes in thin films is needed. This review begins with a discussion of the basic techniques used for measuring stresses in thin films and for studying the mechanical properties of thin films. The proposed models for the origin of stresses in thin films are then reviewed. Finally, the effects of microstructure and substrate constraint on thin film deformation processes are discussed.
An open-label, dose-escalation study to evaluate the safety and pharmacokinetics of CEP-9722 (a PARP-1 and PARP-2 inhibitor) in combination with gemcitabine and cisplatin in patients with advanced solid tumors (2016)

Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors may potentiate chemotherapy by hindering DNA damage repair pathways. CEP-9722 is the prodrug of CEP-8983, a selective inhibitor of PARP-1 and PARP-2. Preclinical studies and a prior phase 1 study suggested that CEP-9722 may cause less myelosuppression than has been observed with other oral PARP inhibitors. The primary objective of this study was to determine the maximum-tolerated dose of CEP-9722 in combination with gemcitabine and cisplatin in patients with advanced solid tumors. All patients received cisplatin 75 mg/m(2) on day 1 and gemcitabine 1250 mg/m(2) on days 1 and 8 of a 21-day cycle. Patients who completed one cycle of chemotherapy alone continued chemotherapy in combination with CEP-9722 150, 200, 300, or 400 mg orally twice daily on days 2-7, with dose-limiting toxicity assessed in cycle 2. Patients experiencing clinical benefit could continue treatment until disease progression or unacceptable toxicity. Thirty-two patients enrolled; 18 patients completed cycle 1 and received chemotherapy plus CEP-9722. The median (range) treatment administration with CEP-9722 was five (1-12) cycles. No patient experienced dose-limiting toxicity with CEP-9722 treatment. Grade 3/4 hematologic adverse events included neutropenia (28%) and leukopenia (11%); adverse events led to discontinuation in 33% of patients. One patient achieved complete response, three had partial responses, and 11 had stable disease; however, the relative contribution of CEP-9722 and/or the chemotherapeutic agents cannot be determined from this single-arm design. This study was discontinued before determination of the maximum-tolerated dose because of highly variable CEP-8983 exposure in all cohorts and toxicity, particularly chemotherapy-induced myelosuppression.
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. (1994)

The proliferative life-span of the stem cells that sustain hematopoiesis throughout life is not known. It has been proposed that the sequential loss of telomeric DNA from the ends of human chromosomes with each somatic cell division eventually reaches a critical point that triggers cellular senescence. We now show that candidate human stem cells with a CD34+CD38lo phenotype that were purified from adult bone marrow have shorter telomeres than cells from fetal liver or umbilical cord blood. We also found that cells produced in cytokine-supplemented cultures of purified precursor cells show a proliferation-associated loss of telomeric DNA. These findings strongly suggest that the proliferative potential of most, if not all, hematopoietic stem cells is limited and decreases with age, a concept that has widespread implications for models of normal and abnormal hematopoiesis as well as gene therapy.
Nursing Countermeasures of Uterine Artery Embolization in Treating Postpartum Hemorrhage (2013)

Objective
To investigate nursing countermeasures of uterine artery embolization (UAE) in treating intractable postpartum hemorrhage(PPH).


Methods
From September 2010 to October 2012, a total of 30 cases with intractable PPH underwent UAE were included into this study. All the cases had ineffective treatment by anti-shock, expansion, bleeding and other conservative therapy. The clinical effects of operation and nursing countermeasures were observed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital. Informed consent was obtained from all participates.


Results
The operation time was (32-87) min, and the operation successful rate was 100.00% (30/30), and all the patients reserved uterus successfully. Among 30 cases, bleeding were successfully controlled in 28 cases (93.33%), no serious complications happened within 7 days after operation.


Conclusions
UAE is a safe and effective therapeutic measure for treating intractable PPH, which is helpful for the rehabilitation.


Key words: 
intractable postpartum hemorrhage; uterine artery embolization; postoperative care