gebhart/patrepeval huggingface dataset:
Portable waveguide display system with a large field of view by integrating freeform elements and volume holograms (2015)

A compact waveguide display system integrating freeform elements and volume holograms is presented here for the first time. The use of freeform elements can broaden the field of view, which limits the applications of a holographic waveguide. An optimized system can achieve a diagonal field of view of 45° when the thickness of the waveguide planar is 3mm. Freeform-elements in-coupler and the volume holograms out-coupler were designed in detail in our study, and the influence of grating configurations on diffraction efficiency was analyzed thoroughly. The off-axis aberrations were well compensated by the in-coupler and the diffraction efficiency of the optimized waveguide display system could reach 87.57%. With integrated design, stability and reliability of this monochromatic display system were achieved and the alignment of the system was easily controlled by the record of the volume holograms, which makes mass production possible.
Cross-Talk Between Iron Metabolism and Diabetes (2002)

Emerging scientific evidence has disclosed unsuspected influences between iron metabolism and type 2 diabetes. The relationship is bi-directional--iron affects glucose metabolism, and glucose metabolism impinges on several iron metabolic pathways. Oxidative stress and inflammatory cytokines influence these relationships, amplifying and potentiating the initiated events. The clinical impact of these interactions depends on both the genetic predisposition and the time frame in which this network of closely related signals acts. In recent years, increased iron stores have been found to predict the development of type 2 diabetes while iron depletion was protective. Iron-induced damage might also modulate the development of chronic diabetes complications. Iron depletion has been demonstrated to be beneficial in coronary artery responses, endothelial dysfunction, insulin secretion, insulin action, and metabolic control in type 2 diabetes. Here, we show that iron modulates insulin action in healthy individuals and in patients with type 2 diabetes. The extent of this influence should be tested in large-scale clinical trials, searching for the usefulness and cost-effectiveness of therapeutic measures that decrease iron toxicity. The study of individual susceptibility and of the mechanisms that influence tissue iron deposition and damage are proposed to be valuable in anticipating and treating diabetes complications.
Anthracycline antibiotics with high liposome entrapment: structural features and biological activity. (1990)

We evaluated the entrapment of 21 different water-insoluble aglycones or anthracycline antibiotics in multilamellar liposomes composed of dimyristoyl phosphatidyl choline and dimyristoyl phosphatidyl glycerol at a 7:3 molar ratio. The drug:lipid weight ratio was 1:15 to 1:50. The different analogues tested were modified at position 4 in the aglycone portion (4-demethoxy) and/or positions 2' (halo), 3' (hydroxy, acetoxy), or 4' (epi, acetoxy) in the sugar portion. The entrapment efficiency was assessed by measuring the amount of free drug remaining in the supernatant after centrifugation of the liposomes and by direct examination of the pellets by fluorescent microscopy. Optimal entrapment (greater than 98%) was observed with only four compounds: 4-demethoxyadriamycinone; 2'-iododaunorubicin; 4-demethoxydaunorubicin; and 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin (Compound 22). All other compounds showed significant drug precipitation outside the multilamellar vesicles when observed by fluorescent microscopy. Compound 22, entrapped in liposomes, was evaluated in vivo against i.p. L-1210 leukemia by the i.p. route, and liver metastases of M5076 reticulosarcoma by the i.v. route. In both models, liposome-entrapped Compound 22 was more active than doxorubicin at the optimal dose [median survival (given in percentage) of treated to control animals was for L-1210, greater than 600 versus 212; for M5076, 200 versus 133]. 4-Demethoxy and 2'-iodo are structural modifications that markedly enhance the affinity of anthracycline antibiotics for lipid bilayers without compromising biological activity. These findings will serve as a guideline to obtain liposome-anthracycline preparations, with optimal formulation characteristics, enhanced tumor-targeting properties, and non-cross-resistance with doxorubicin.
Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans (1994)

Certain members of the indigenous biota of humans produce antimicrobial substances called bacteriocins, which inhibit other bacteria, including members of their own species. One of these substances, mutacin, is made by Streptococcus mutans, a member of the oral biota. Mutacin inhibits other mutans streptococci as well as many gram-positive exogenous pathogens. Here, we report for the first time the purification and partial biochemical characterization of a lanthionine-containing mutacin peptide from S. mutants T8. The biologically active peptide was isolated from the broth cultures by ultrafiltration and differential precipitation. The final mutacin preparation was homogeneous as shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and N-terminal amino acid sequencing. A molecular mass of the peptide was estimated by electrospray ionization mass spectroscopy to be 3,244.64 +/- 1.15 Da. Its amino acid composition indicates the presence of lanthionine and likely beta-methyllanthionine in a total of about 25 amino acids. Because alpha,beta-unsaturated amino acids, the precursors of lanthionine residues, are often found in lantibiotics, we carried out the addition reaction of the mutacin with N-(methyl)mercaptoacetamide. The subsequent electrospray ionization mass spectroscopy analysis indicated the presence of two reaction products with M(r)s of 3,350.45 and 3,456.0. These are interpreted as the mutacin molecule with the addition of one and two molecules of reagent to the unsaturated amino acids, respectively. Sequencing of the peptide revealed an N-terminal amino acid sequence of Asn-Arg-Trp-Trp-Gln-Gly-Val-Val.
Proton T1ρ‐dispersion imaging of rodent brain at 1.9 T (1998)

Detection of H2(17)O with proton T1rho-dispersion imaging holds promise as a means of quantifying metabolism and blood flow with MRI. However, this technique requires a priori knowledge of the intrinsic T1rho dispersion of tissue. To investigate these properties, we implemented a T1rho imaging sequence on a 1.9-T Signa GE scanner. A series of T1rho images for different locking frequencies and locking durations were obtained from rat brain in vivo and compared with 5% (wt/vol) gelatin phantoms containing different concentrations of (17)O ranging from .037% (natural abundance) to 2.0 atom%. Results revealed that, although there is considerable T1rho-dispersion in phantoms doped with H2(17)O, the T1rho of rat brain undergoes minimal dispersion for spin-locking frequencies between .2 and 1.5 kHz. A small degree of T1rho dispersion is present below .2 kHz, which we postulate arises from natural-abundance H2(17)O. Moreover, the signal-to-noise ratios of T1rho-weighted images are significantly better than comparable T2-weighted images, allowing for improved visualization of tissue contrast. We have also demonstrated the feasibility of proton T1rho-dispersion imaging for detecting intravenous H2(17)O on a live mouse brain. The potential application of this technique to study brain perfusion is discussed.
Design and Evaluation of a Low-Cost Force Feedback System for Myoelectric Prosthetic Hands (2006)

In Brief Myoelectrically powered prosthetic hands lack sensory feedback relating to the force exerted by the artificial hand on a grasped object. The degree of control is imprecise, and often much more force than necessary is applied. The aim of this study was to develop and evaluate a force feedback system considering design constraints, providing the user with closed-loop control. Different methods and design criteria for providing myoelectric prosthetic hands with force feedback were analyzed, with stimulation by vibration being preferred. A new feedback system was designed, consisting of a miniature vibration motor, a piezoresistive force sensor, and control electronics. Grasping forces with and without feedback were recorded and compared from five habitual myoelectric hand users when grasping a hand dynamometer with different weights attached to it. All five patients rapidly improved their ability to regulate the grasping force without the help of vision when feedback was applied. An average force reduction of 37% was found when vibration was applied indirectly to the hand, and a decrease of 54% was found when feedback was applied directly to the skin of the residual limb. Constraints for a prosthetic force feedback system such as low power consumption, compactness, and being imperceptible to others are included in the design. General acceptance of vibration as a feedback signal was good, especially when applied indirectly. The results indicate that the new system is of potential value for myoelectric prosthetic hand users. More precise control is possible, and redundant grasping force can be diminished with a feedback system. A new system may offer valuable assistance to myoelectric prosthetic hand users to more accurately gauge the force needed for a particular task. People with such artificial hands suffer from a lack of adequate feedback compared with body-powered prostheses. Different methods for providing myoelectric prosthetic hands with force feedback were analyzed, and a new feedback system was designed, consisting of a sensor capable of changing its resistance under physical pressure, a miniature vibration motor, and control electronics.
The state of the art in electronic payment systems (1997)

The exchange of goods conducted face-to-face between two parties dates back to before the beginning of recorded history. Traditional means of payment have always had security problems, but now electronic payments retain the same drawbacks and add some risks. Unlike paper, digital "documents" can be copied perfectly and arbitrarily often, digital signatures can be produced by anybody who knows the secret cryptographic key, and a buyer's name can be associated with every payment, eliminating the anonymity of cash. Without new security measures, widespread electronic commerce is not viable. On the other hand, properly designed electronic payment systems can actually provide better security than traditional means of payments, in addition to flexibility. This article provides an overview of electronic payment systems, focusing on issues related to security.
Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases. (2005)

The MDHAQ physical function scale of 10 ADL is more easily completed and scored than the 14-ADL MDHAQ or 20-ADL HAQ, while providing similar information.
Ivermectin-Responsive <i>Demodex</i> Infestation during Human Immunodeficiency Virus Infection (2002)

We report the case of a 56-year-old HIV-seropositive man who presented a facial Demodex infection developed 2 months after initiation of highly active antiretroviral therapy. The Demodex infection was confirmed by scrapings and histopathologic examination and by the dramatic response to antiparasitic treatment with oral ivermectin associated with 5% permethrin cream.
Specific Targeting of Antisense Oligonucleotides to Neutrophils (1994)

The ability of three different hydrophobic ligands (cholic acid, cholesterol, and the tetrapeptide fMLFY) to increase the uptake of an antisense (anti-actin) oligomer into neutrophils was analyzed. In agreement with the literature (Boutorin et al., 1989; Letsinger et al., 1989), we found that cholic acid and cholesterol conjugates greatly enhance the uptake of anti-actin oligomer. When fMLFY is the ligand, the cellular uptake is much less than that of anti-actin oligomer alone, but the biological consequences are much more significant. Our results are consistent with the hypothesis that the fMLFY conjugate of the anti-actin oligomer is internalized via a different route, and reaches its target site most efficiently.
Factors Affecting Separations of Suspensions in Nonuniform Electric Fields (1959)

A study of the more quantitative aspects of the behavior of suspended polymer particles in a real dielectric is presented. While it is recognized that nonuniform fields exert an attractive force of appreciable magnitude upon particles of high dielectric constant suspended in a liquid medium of lower dielectric constant, the limits of such behavior are not precisely known. This report presents some quantitative data on the subject. The results show that in real dielectrics there is an appreciable effect due to the very small currents, about 1013 amperes at applied voltages in the kilovolt range [R. Coelho, Progress Report No. 22, pp. 13–17, Laboratory for Insulation Research, Massachusetts Institute of Technology (December, 1957)] which even a good liquid insulator supports. It is shown that the initial attraction to the central electrode due to the nonuniform field and its polarizing induction is gradually overcome by the repulsive effects of charge accumulated on the particles resulting from ionic conduction and related events in the liquid. The experimental observations include the study of the effects of field strength, electrode size, cell size, and particle size. Field strength, electrode size, and particle size show criticality. At certain upper limiting voltages, smaller central electrode diameters and small particle sizes, all precipitation appears to be prohibited. Use of the newly discovered ``sluff-off'' voltage for making particle size separations is discussed.
Unraveling Social Knots. (Artists Pages) (2001)

WAS TEACHING HIGH SCHOOL IN SUBURBAN DENVER TOLD KIM TO GET THE PIECE OF JEWELRY OUT OF THE SULFURIC ACID SOLUTION WITH HER FINGERS MY PARTNER HAD A LESION ON HIS TONGUE THE SIZE OF A QUARTER THAT WAS BLEEDING PROFUSELY THREW AN ERASER AT JAMIE AND CUT HER ON TOP OF HER FOREHEAD STARTED PROZAC AND DIAZEPAM The time with my partner seemed to crawl along. His muscular body wizened up. His medical records indicated the wasting but cited that he had the torso of an athlete...with a shunt. The events that followed were typical for people who were dying as a result of AIDS in 1991: Karposi's Sarcoma (KS), Pneumocystis and general body aches. As the virus accelerated my emotions became flatter. My memory changed from reasonably sharp (I saw 150 students daily) to a muddle in between isolated events. As the decay of John's body advanced told my mother that John had cancer. was concerned about her reaction to AIDS because, as Douglas Crimp states in Mourning and Militancy, Seldom has a society so savaged people during their hour of loss. She told me to never come home again. This became the source of schisms that acted to form new knots and tighten old ones, both consciously and unconsciously. Nonsister banned me from her home because if John had it then had it and if played with her children would sweat and the virus would go into their bodies through their skin, enter their blood streams and they would die. The significant part of her statement had to do with the power that she and other cultural factors had over me. I need to protect my children so you can never see them again is a discursive trope that she used to position her power over her perverse big brother. This statement and my mother's edict are performative acts as described by Judith Butler in Critically Queer. Performative acts are forms of authoritative speech. Implicated in a network of authorization and punishment...[they] confer the binding power on the action performed. To Nonsister and Mother became symbolic of AIDS, death and homosexuality. also became a vehicle for them to position themselves as the authority and punisher of me in order to displace their homophobia and AIDSphobia. For me, my main system of support was lost and family became symbolic of the dominant order fighting to survive by using aberration to help define and legitimize that dominance. …
Input of microenvironmental regulation on colorectal cancer: Role of the CCN family (2014)

Colorectal cancer (CRC) is a major health problem causing significant morbidity and mortality. Previous results from various studies indicate that CRC tumorigenicity encompasses tumor microenvironment, emphasizing the complex interacting network between cancer cells and nearby host cells, which triggers diverse signaling pathways to promote the growth and spread of cancer cells. The CCN family proteins share a uniform modular structure, mediating a variety of physiological functions, including proliferation, apoptosis, migration, adhesion, differentiation, and survival. Furthermore, CCN proteins are also involved in CRC initiation and development. Many studies have shown that CCN members, such as CCN1, CCN2, CCN3, Wnt-induced secreted protein (WISP)-1, WISP-2, and WISP-3, are dysregulated in CRC, which implies potential diagnostic markers or therapeutic targets clinically. In this review, we summarize the research findings on the role of CCN family proteins in CRC initiation, development, and progression, highlighting their potential for diagnosis, prognosis, and therapeutic application.
Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin. (1991)

Regimens using cyclosporin (CSP) and either methylprednisolone (MP) or methotrexate (MTX) have been useful in the prophylaxis of acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT). However, CSP produces a number of side effects, including neurologic toxicity. A retrospective review of recipients of 239 BMTs given CSP-based prophylactic regimens revealed that 10 patients (4.2%, 95% confidence interval 0% to 10.4%) experienced a syndrome characterized by hypertension, severe visual disturbances, seizures and occipital lobe density changes on brain computed tomography (nine patients) or nuclear magnetic resonance imaging (one patient). Neurologic findings were reversible in all cases, usually after temporary discontinuation of CSP. Univariate analysis identified the following risk factors for neurotoxicity: use of unrelated or HLA-mismatched related donors, administration of etoposide (VP-16) or total body irradiation as part of conditioning, use of corticosteroids for prophylaxis or treatment of acute GVHD, or development of either acute GVHD or clinically significant microangiopathic hemolytic anemia (MAHA) post-BMT. In multivariate analysis, the most important predictors were the use of VP-16 (p = 0.008), the use of a continuous infusion CSP plus MP prophylactic regimen for GVHD (p = 0.003) and the development of MAHA after BMT (p less than 0.001). The strong association with MAHA suggests that endothelial damage is related to the development of this complication.
Subtraction scanning acoustic microscopy reveals motility domains in cells in vitro (1994)

Scanning acoustic microscopy (SAM) observes all mechanical properties of living cells. Subtraction of the SAM images (SubSAM) of live cells was developed as a method for investigating minimal changes in cellular topography and elasticity. The image formation in the SubSAM takes into account the motion of cell mass as well as the changes of tension. High spatial and temporal resolution of the SubSAM revealed the structure of motile processes that develops at increasing time intervals, thus allowing the arising complexity of motion to be registered and investigated. Independent spots of activity emerge on a quiescent background as motility domains; they may change position, divide, merge, or disappear after a long time interval. In addition, zones of quiescence were identified over central parts of cytoplasmic lamellae. Nonmalignant (Ep: tadpole epidermal cells, XTH2: endothelial cells from tadpole hearts, 3T3 cells) and neoplastic cells (K2 cells of rat fibrosarcoma, A870N cells selected from K2) were investigated with the SubSAM. Three types of domains of subcellular cytoplasmic motility were identified in time series of two-dimensional SubSAM iamges in normal and neoplastic cells. Of them only the wave-like domain is self-evident, being derived from ruffling and protruding activity at the cell margin. Two other domains wait for detailed analysis. The oscillating domain is a visualization of tension within the cell(s), and the nucleating domain indicates intracellular processes possibly preceding locomotion. Differences in motile domains were found between low K2 and high A870N metastatic cells. The dynamics of motility domains of the A870N cells resembled that of the highly motile Ep cells. Cell morphotype and motile activity of the A870N cells are significantly influenced by the pH of the medium. It became evident that identification of the otherwise invisible motile domains in living cells by SubSAM opens a new approach to a characterization of cell motility in vitro and to an understanding of early cellular reactions to various stimuli.
Loop-type ground antenna using resonated loop feeding, intended for mobile devices (2011)

A loop-type ground antenna, designed as a rectangular ground clearance connected by a capacitor, is proposed for mobile devices. The electromagnetic mechanism underlying the antenna operation is based on a new feeding method; a capacitor is used to cause a current loop to resonate at the operating frequency band. The proposed antenna is 5×3 mm and is easily implemented within mobile devices. The −10 dB bandwidth of the antenna is 400 MHz, from 2.3 to 2.7 GHz. The radiation pattern it produces shows omnidirectional performance on the horizontal plane.
Nitric Oxide Signaling in the Central Nervous System (1995)

Nitric oxide (NO) was first recognized as a messenger molecule in the central nervous system (eNS) in 1988 (52), when it was identified as the unstable intercellular factor that had been hypothesized, a year earlier (53), to mediate the increased cyclic GMP (cGMP) levels that occur on activation of glutamate receptors, particularly those of the NMDA (N-methyl-D-aspartate) subtype. The presence of an NO-forming enzyme (NO synthase, or NOS) in the brain was later confirmed (74), and this enzyme was subsequently purified (14) and its cDNA cloned and sequenced (12). The discovery that NO functions as a signaling molecule in the brain opened a new dimension in our concept of neural communication, one overlaying the classical picture of chemical neurotransmission, where information is passed between neuronal elements at discrete loci (synapses), and in one direction, with a diffusive type of signal that disregards the spatial constraints on neu­ rotransmitter activity normally imposed by membranes, transporters, and in­ activating enzymes. In principle, NO could spread out from its site of produc­ tion to influence many different tissue elements (neuronal, glial, and vascular) that are not necessarily in close anatomical juxtaposition. During the past few years, much information on the enzymology and mo­ lecular characteristics of NO synthesis has accrued, as reviewed in other articles in this volume. Furthermore, data from immunocytochemistry, in situ hybridization, and NADPH diaphorase histochemistry have combined to give
Efficacy and Tolerability of Lodenafil Carbonate for Oral Therapy in Erectile Dysfunction: A Phase II Clinical Trial (2008)

LC showed a satisfactory efficacy-safety profile for oral therapy of ED.