gebhart/patrepeval huggingface dataset:
Two-Step Functionalization of Neutral and Positively Charged Thiols onto Citrate-Stabilized Au Nanoparticles (2004)

We propose a two-step approach to functionalize gold nanoparticles prepared by reducing tetrachloroauric acid by trisodium citrate in water. The chloride and citrate physisorbed on the gold nanoparticles are first displaced by thioctic acid (TA), which is then exchanged by thiols containing the desired functionality during the second step. TA bears a carboxylate group and disulfide; at high pH, the negative charge of the former stabilizes gold nanoparticles and the disulfide develops two S−Au bonds, retarding the desorption kinetics upon further functionalization. The slow kinetics of TA desorption is crucial to establishing sufficient steric stabilization for the gold core while losing electrostatic stabilization. Successful attachment of carboxylate, crown ether, cyclodextrin, pyridine, and amino functionalities is verified by surface sensitive techniques. In most cases, ca. 80% of the TA molecules are displaced. The nanoparticles are stable under solution pH where the surface group is ionized. Although at certain solution acidities, the gold sols have difficulty carrying charges and appear flocculated, the nanoparticles become dispersive after being centrifuged and redissolved in suitable buffer solutions, which indicates the successful protection of the gold cores by steric stabilization.
Enhancement of a chemical reaction rate by proper orientation of reacting molecules in the solid state (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnhancement of a chemical reaction rate by proper orientation of reacting molecules in the solid stateChaim N. Sukenik, Jose A. P. Bonapace, Neil S. Mandel, Robert G. Bergman, Pui-Yan Lau, and Gordon WoodCite this: J. Am. Chem. Soc. 1975, 97, 18, 5290–5291Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://pubs.acs.org/doi/10.1021/ja00851a051https://doi.org/10.1021/ja00851a051research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A 3-$\mu\hbox{W}$ CMOS Glucose Sensor for Wireless Contact-Lens Tear Glucose Monitoring (2011)

This paper presents a noninvasive wireless sensor platform for continuous health monitoring. The sensor system integrates a loop antenna, wireless sensor interface chip, and glucose sensor on a polymer substrate. The IC consists of power management, readout circuitry, wireless communication interface, LED driver, and energy storage capacitors in a 0.36-mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> CMOS chip with no external components. The sensitivity of our glucose sensor is 0.18 μA·mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ·mM <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . The system is wirelessly powered and achieves a measured glucose range of 0.05-1 mM with a sensitivity of 400 Hz/mM while consuming 3 μW from a regulated 1.2-V supply.
An Overlay Architecture for High-Quality VoIP Streams (2006)

The cost savings and novel features associated with voice over IP (VoIP) are driving its adoption by service providers. Unfortunately, the Internet's best effort service model provides no quality of service guarantees. Because low latency and jitter are the key requirements for supporting high-quality interactive conversations, VoIP applications use UDP to transfer data, thereby subjecting themselves to quality degradations caused by packet loss and network failures. In this paper, we describe an architecture to improve the performance of such VoIP applications. Two protocols are used for localized packet loss recovery and rapid rerouting in the event of network failures. The protocols are deployed on the nodes of an application-level overlay network and require no changes to the underlying infrastructure. Experimental results indicate that the architecture and protocols can be combined to yield voice quality on par with the public switched telephone network
Multiple attenuation in complex geology with a pattern-based approach (2005)

Abstract Primaries (signal) and multiples (noise) often exhibit different kinematics and amplitudes (i.e., patterns) in time and space. Multidimensional prediction-error filters (PEFs) approximate these patterns to separate noise and signal in a least-squares sense. These filters are time-space variant to handle the nonstationarity of multioffset seismic data. PEFs for the primaries and multiples are estimated from pattern models. In an ideal case where accurate pattern models of both noise and signal exist, the pattern-based method recovers the primaries while preserving their amplitudes. In the more general case, the pattern model of the multiples is obtained by using the data as prediction operators. The pattern model of the primaries is obtained by convolving the noise PEFs with the input data. In this situation, 3D PEFs are preferred to separate (in prestack data) the multiples properly and to preserve the primaries. Comparisons of the proposed method with adaptive subtraction with an ℓ2 norm demonstrate that for a given multiple model, the pattern-based approach generally attenuates the multiples and recovers the primaries better. In addition, tests on a 2D line from the Gulf of Mexico demonstrate that the proposed technique copes fairly well with modeling inadequacies present in the multiple prediction.
A hybrid computational model for ultrasound phased-array heating in presence of strongly scattering obstacles (1997)

A computationally efficient hybrid ray-physical optics (HRPO) model is presented for the analysis and synthesis of multiple-focus ultrasound heating patterns through the human rib cage. In particular, a ray method is used to propagate the ultrasound fields from the source to the frontal plane of the rib cage. The physical-optics integration method is then employed to obtain the intensity pattern inside the rib cage. The solution of the matrix system is carried out by using the pseudo inverse technique to synthesize the desired heating pattern. The proposed technique guides the fields through the intercostal spacings between the solid ribs and, thus, minimal intensity levels are observed over the solid ribs. This simulation model allows for the design and optimization of large-aperture phased-array applicator systems for noninvasive ablative thermal surgery in the heart and liver through the rib cage.
Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses (2004)

Bruton tyrosine kinase (Btk), a non-receptor-associated tyrosine kinase of the Tec family, appears to participate in many myeloid cell functions. We show that macrophages from X-linked immunodeficient (XID) mice lacking functional Btk cannot generate efficient bursts of reactive oxygen intermediates (ROIs). The induction of apoptotic cell death by inflammatory stimuli is also enhanced in XID macrophages. Phagocytosis of bacterial particles is only marginally affected in them. In vivo, XID mice show reduced severity of inflammatory diseases in models of experimental autoimmune encephalomyelitis (EAE), dextran sulfate sodium (DSS)-induced colitis, and carrageenan-induced acute edema. Also, polymorphonuclear neutrophil granulocytes (PMNs) in XID mice show poor ROI and nitric oxide (NO) induction, along with a reduction in PMN recruitment to peritoneal inflammation. XID mice show reduction in PMN numbers in peripheral blood, and their bone marrow shows a reduction in the numbers of both monocytic and granulocytic lineages, extending to the earliest progenitor populations. Thus, Btk is likely to play a significant role at multiple points during the development and functioning of the myeloid lineages, affecting the outcome of many infectious as well as noninfectious inflammatory events in vivo.
STAT proteins as novel targets for cancer therapy (1999)

Although the signal transducer and activator of transcription (STAT) proteins were originally discovered through the study of interferon-induced responses, a large number of cytokines and growth factors have been found to activate STATs. In addition to the fundamental role of STAT pathways in normal cell signaling, accumulating evidence is defining a critical role for STATs in oncogenesis. STAT family members are constitutively activated by various oncoproteins in transformed cells and are found activated in a wide variety of human tumors, including breast cancer and diverse blood malignancies. This review discusses recent progress in understanding how aberrant activation of STAT signaling pathways participates in malignant progression of human cancers. Current evidence indicates that one mechanism by which STATs contribute to oncogenesis involves prevention of programmed cell death, or apoptosis, thereby conferring a survival advantage and, potentially, resistance to chemotherapy. These advances identify STATs as novel molecular targets for development of promising therapeutics against human cancers that harbor activated STAT proteins.
Peptide Dendrimers as Artificial Enzymes, Receptors, and Drug-Delivery Agents (2006)

The dendritic architecture applied to peptides provides a practical entry into globular macromolecules resembling proteins. A modular design was chosen using a divergent synthesis on solid support alternating proteinogenic alpha-amino acids with branching diamino acids, producing peptide dendrimers with a molecular weight of 3-5 kDa. Initial studies focused on models for hydrolases and produced esterase peptide dendrimers featuring histidine as the key catalytic residue. Variations of amino acid composition and the branching diamino acid led to enantioselective catalysts. Rate accelerations of k(cat)/k(uncat) = 90,000 were obtained when the design was changed to monomeric peptide dendrimers alternating two amino acids with the branching unit. A combinatorial approach was developed allowing for the preparation of large libraries (>60,000 members), which were screened for B12 binding and catalytic activity. The peptide dendrimers were also investigated for drug delivery. Glycopeptide dendrimers conjugated to colchicine selectively inhibited the proliferation of targeted cells, whereas colchicine alone displayed high toxicity.
Micro-nano hybrid structures with manipulated wettability using a two-step silicon etching on a large area (2011)

Nanoscale surface manipulation technique to control the surface roughness and the wettability is a challenging field for performance enhancement in boiling heat transfer. In this study, micro-nano hybrid structures (MNHS) with hierarchical geometries that lead to maximizing of surface area, roughness, and wettability are developed for the boiling applications. MNHS structures consist of micropillars or microcavities along with nanowires having the length to diameter ratio of about 100:1. MNHS is fabricated by a two-step silicon etching process, which are dry etching for micropattern and electroless silicon wet etching for nanowire synthesis. The fabrication process is readily capable of producing MNHS covering a wafer-scale area. By controlling the removal of polymeric passivation layers deposited during silicon dry etching (Bosch process), we can control the geometries for the hierarchical structure with or without the thin hydrophobic barriers that affect surface wettability. MNHS without sidewalls exhibit superhydrophilic behavior with a contact angle under 10°, whereas those with sidewalls preserved by the passivation layer display more hydrophobic characteristics with a contact angle near 60°.
[Pathological changes and apoptosis of brain cells in rat embryo suffering from intrauterine hypoxia-ischemic injury]. (2004)

Uterine hypoxia and ischemia can cause severe damage to neural cells of fetal rat.
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists (2011)

A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavailable analogues that showed efficient NR2B receptor occupancy in rats. Unlike nonselective NMDA antagonists, the NR2B-selective antagonist 22 showed no adverse affects on motor coordination in the rotarod assay at high dose. Compound 22 was efficacious following oral administration in a spinal nerve ligation model of neuropathic pain and in an acute model of Parkinson's disease in a dose dependent manner.
Fractionation of normal and beta-thalassemic human hemopoietic progenitor cells by immunomagnetic beads. (1987)

Depletion of adherent cells, followed by simultaneous immunomagnetic bead depletion of Leu 4+, Leu 7+, Leu 11+, Leu M1+, Leu M3+, B1+, WEM-G11+, and Glycophorin A+ cells from normal bone marrow mononuclear cells, consistently led to recoveries of erythroid and nonerythroid colony-forming cells of greater than 100% and enrichment of 13- to 99-fold. Similarly, the recovery of mixed erythroid colony-forming cells was greater than 100%, with enrichments of 7.5- to 262-fold. This simple procedure, when used on normal bone marrow and beta-thalassemic peripheral blood mononuclear cells, as well as providing significant enrichment, suggests that colony assays on unfractionated human mononuclear cells specifically underestimate the number of BFU-E, Mix-CFC, and nonerythroid-CFC present.
Antibodies to Peptides Detect New Hepatitis B Antigen: Serological Correlation with Hepatocellular Carcinoma (1985)

The expression of a previously unidentified gene product, encoded by the hepatitis B virus (HBV) genome, has been achieved with a recombinant SV40 expression vector. Antibodies against synthetic peptides representing defined regions of this protein were used to screen cells infected with recombinant virus as well as tissues naturally infected with HBV. A 24,000-dalton protein (p24) was detected in cells infected with recombinant virus and a 28,000-dalton protein (p28) was detected in tissues infected with HBV. The peptides or recombinant-derived protein were used as antigens to screen sera from individuals infected with HBV. Specific antibodies were detected predominantly in sera from patients with hepatocellular carcinoma. The presence of p28 in tissues infected with HBV and the appearance of specific antibodies in infectious sera establish the existence of an additional marker for HBV infection.
Chemical Synthesis of Circular RNAs with Phosphoramidate Linkages for Rolling‐Circle Translation (2021)

Recently, many types of circular RNAs have been reported in human cells. One interesting aspect of circular RNAs is their translation into proteins. We previously discovered that circular RNA without a stop codon can be translated into long repeating peptides via rolling-circle translation in both prokaryotic and eukaryotic systems. Because the rate-limiting step of translation-ribosome binding-occurs only once in rolling-circle translation, the translation efficacy is very efficient compared to translation of linear mRNAs. However, preparation of circular RNAs involves costly and time-consuming enzymatic methods, and there was no practical non-enzymatic method. We recently reported a chemical synthesis strategy using short RNA fragments and one or two phosphoramidate linkages. In this article, we describe the chemical synthesis and purification methods for preparation of circular RNAs for rolling-circle translation. © 2021 Wiley Periodicals LLC. Basic Protocol 1: Synthesis of 3'-amino-modified guanosine controlled-pore glass Basic Protocol 2: Solid-phase synthesis of linear RNA fragments Basic Protocol 3: Chemical synthesis of circular RNAs.
The chemistry of 4H‐3,1‐benzoxazin‐4‐ones (1999)

Abstract The present review covers the synthesis and reactions of 4 H ‐3,1‐Benzoxazin‐4‐ones. Only those with carbon substituents at the 2‐position are included. Literature corverage includes publications primarily from the mid 1960's to May 1998.
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity (2006)

The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. Screening of our kinase-preferred collection identified aminoquinazoline 1 as a potent, nonselective inhibitor of Lck and T cell proliferation. In this report, we describe the synthesis and structure-activity relationships of a series of novel aminoquinazolines possessing in vitro mechanism-based potency. Optimized, orally bioavailable compounds 32 and 47 exhibit anti-inflammatory activity (ED(50) of 22 and 11 mg/kg, respectively) in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
Experimental Demonstration of the Role of Anisotropy in Interfacial Pattern Formation (1985)

We impose anisotropy in modified Hele-Shaw experiments by engraving a grid on one of the plates. Without anisotropy, the dynamics is dominated by tip bifurcations leading to a branched ramified structure. With anisotropy, a dendritic pattern forms, in qualitative agreement with the prediction of recent studies of local growth models.
Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors (1998)

Development of analgesic agents for the treatment of severe pain requires the identification of compounds that are devoid of opioid receptor liabilities. A potent (inhibition constant = 37 picomolar) neuronal nicotinic acetylcholine receptor (nAChR) ligand called ABT-594 was developed that has antinociceptive properties equal in efficacy to those of morphine across a series of diverse animal models of acute thermal, persistent chemical, and neuropathic pain states. These effects were blocked by the nAChR antagonist mecamylamine. In contrast to morphine, repeated treatment with ABT-594 did not appear to elicit opioid-like withdrawal or physical dependence. Thus, ABT-594 may be an analgesic that lacks the problems associated with opioid analgesia.
Surface Micromachined Millimeter-Wave Log-Periodic Dipole Array Antennas (2012)

Two wideband millimeter-wave end-fire log-periodic dipole array (LPDA) antennas are designed and fabricated using a sequential surface micromachining. The antennas are excited by monolithically integrating a micro-coaxial line feed in the antenna's lower boom designed to provide band rejection at 60 GHz. Antennas 1 and 2 are designed to operate in 18–110 GHz and 18 GHz–50 GHz bands, and measured up to 40 GHz and 50 GHz, respectively. <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">${\rm VSWR}&lt;2.5$</tex></formula> is obtained for both antennas throughout the measured bandwidth. Measured directivity around 10 dBi and consistent E and H-plane 3 dB beamwidths around 56 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$^{\circ}$</tex></formula> and 72 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$^{\circ}$</tex></formula> , respectively, are obtained for Antenna 2 throughout its bandwidth. Good pattern correlation between measured and simulated results is also achieved. This paper clearly demonstrates that the wideband high-quality millimeter-wave end-fire LPDAs are now possible.
Microwave Bandstop Filters with Narrow Stop Bands (1962)

In most microwave systems the signal frequency has to be transmitted and guided from one place to another with the minimum of attenuation, while guarding against unwanted frequencies by keeping them out with bandpass filters, which pass only the signal frequency. While the common types of bandpass filters do an adequate job for most applications, they suffer from some disadvantages in particular situations. It may, for instance, happen that some one interfering frequency is particularly strong and special measures have to be taken to suppress it; or that a limited number of frequencies are being generated in a frequency generator system, but these frequencies have to be kept apart and pure. In those cases, a bandpass filter, which discriminates against all frequencies outside the passband, will not be as efficient as one or more bands top filters which discriminate especially against the strongest unwanted frequencies,
Expression of Human Endogenous Retrovirus env Genes in the Blood of Breast Cancer Patients (2014)

Human endogenous retroviruses (HERV) env proteins have been recently reported to be significantly up-regulated in certain cancers. Specifically, mRNA and protein levels of HERV-K (HML-2) are up-regulated in the blood plasma or serum of breast cancer patients. Here, we collected blood samples of 49 breast cancer patients and analyzed mRNA expressions of various HERVs env genes including HERV-R, HERV-H, HERV-K, and HERV-P by real-time PCR. The expression of env genes were significantly increased in the blood of primary breast cancer patients but were decreased in patients undergoing chemotherapy to a similar level with benign patients. When we compared the group currently undergoing chemotherapy and those patients undergoing chemotherapy simultaneously with radiotherapy, HERVs env genes were reduced more in the chemotherapy only group, suggesting that chemotherapy is more effective in reducing HERV env gene expression than is radiotherapy. Among chemotherapy groups, HERV env gene expression was the lowest in the taxotere- or taxol-treated group, suggesting that taxotere and taxol can reduce HERVs env expression. These data suggest the potential to use HERVs env genes as a diagnosis marker for primary breast cancer, and further studies are needed to identify the mechanism and physiological significance of the reduction of HERV env gene expression during chemotherapy.