gebhart/patrepeval huggingface dataset:
Phase Transitions in Collagen and Gelatin Systems1 (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase Transitions in Collagen and Gelatin Systems1Paul J. Flory and Robert R. GarrettCite this: J. Am. Chem. Soc. 1958, 80, 18, 4836–4845Publication Date (Print):September 1, 1958Publication History Published online1 May 2002Published inissue 1 September 1958https://pubs.acs.org/doi/10.1021/ja01551a020https://doi.org/10.1021/ja01551a020research-articleACS PublicationsRequest reuse permissionsArticle Views1386Altmetric-Citations300LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines (2004)

In weakly and poorly immunogenic tumor models, we examined the effects of stimulating CD137 (4-1BB) in vivo by administering anti-CD137 monoclonal antibody after tumor lysate-pulsed dendritic cell (TP-DC) vaccination. TP-DC subcutaneous vaccination induced a transient up-regulation of CD137 on T cells and natural killer (NK) cells within vaccine-primed lymph nodes (VPLNs). In established pulmonary and subcutaneous tumor models, anti-CD137 synergistically enhanced tumor regression after TP-DC vaccination. In the subcutaneous tumor model, the combined therapy resulted in improved survival. Combined therapy also resulted in improved local control of subcutaneous tumor after surgical resection. Anti-CD137 polarized the cytokine release of VPLNs and spleen cells in response to tumor antigen toward a type 1 (interferon-gamma) versus a type 2 (interleukin-4) profile. Cell depletion and the use of knockout animals identified that CD8(+), CD4(+), and NK cells were involved in the tumor rejection response and that CD8(+) cells had the major effector role. Anti-CD137 administration resulted in increased proliferation of adoptively transferred OT-1 CD8(+) T cells in the VPLNs of mice inoculated with B16-OVA TP-DCs. Polarization toward type 1 (interferon-gamma) versus type 2 (interleukin-4) was also observed with the OT-1 cells from VPLNs and spleen cells after anti-CD137 injections. This polarization effect was abrogated by the in vivo depletion of NK cells. These findings indicate that the adjuvant effect of anti-CD137 given in conjunction with TP-DC vaccination is associated with the polarization of T effector cells toward a type 1 response to tumor antigen and is mediated via NK cells.
Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae (1999)

Natural competence in Streptococcus pneumoniae is regulated by a quorum-sensing mechanism consisting of a competence-stimulating peptide (CSP), its dedicated secretion apparatus (ComAB), its histidine kinase receptor (ComD) and a response regulator (ComE). In this report, we show that ComE is a DNA-binding protein that acts autocatalytically by binding to a region in its own promoter. Two additional ComE binding sites were identified in the pneumococcal genome, one in the promoter region of comAB and the other upstream of an ABC transporter of unknown function. A comparison of the ComE-binding sequences with the sequence motif previously found to be involved in the co-ordinated expression of the late genes revealed that they are unrelated. These findings indicate that ComE activates transcription of the late genes indirectly, i.e. via one or more intermediate factors.
Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme (2013)

Cyclooxygenase (COX) enzyme is responsible for the formation of important biological mediators including prostaglandins, prostacyclin and thromboxane to trigger many physiological and patho-physiological responses. COXs exist in two distinct isoforms, a constitutively expressed form (COX-1) and an inducible form (COX-2). COX-2 is involved in the body's response to inflammation and pain. Moreover, it has also been shown that COX-2 is overexpressed in many human cancers, and that COX-2 is involved in various neurodegenerative diseases such as Parkinson's and Alzheimer's disease. COX-2 inhibitors are among the most widely used therapeutics for the treatment of chronic and acute pain and inflammation. Non-invasive monitoring of COX-2 functional expression by means of nuclear molecular imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) might provide unique opportunities to obtain data on COX-2 expression levels during disease manifestation and progression to study potential roles of COX-2 under various pathological conditions. The present review summarizes recent research efforts directed to the design and synthesis of radiotracers as molecular probes with special emphasis on COX-2 imaging.
Endothelial Nitric Oxide Synthase as a Potential Susceptibility Gene in the Pathogenesis of Emphysema in α 1-Antitrypsin Deficiency (1999)

A role for endothelial nitric oxide synthase (NOS3) in the susceptibility of individuals with alpha1-antitrypsin (alpha1AT) deficiency to destructive lung disease was evaluated. Six polymorphic sites were identified within the NOS3 gene (i.e., -924A/G, -788C/T, -691C/T, 774C/T, 894G/T, and 1998C/G). The genotype distribution was determined in 339 patients and 94 control individuals. Frequency of the 774T allele in severely affected individuals was 0.417 versus 0.269 in control subjects (P = 0.018), whereas the 894T allele frequency was 0.427 versus 0.280 in control subjects (P = 0.024). Patients with less severe lung disease had the 774T and 894T allele frequencies of 0.289 and 0.344, respectively, similar to frequencies in a control group (P > 0.3). No direct correlation between pulmonary function and five other NOS3 polymorphisms was observed. Thus, functional allelic variants that are in linkage disequilibrium with the 774C/T and 894G/T may be present in the specified genomic area. These data are consistent with a modulatory role for NOS3 in destructive lung disease associated with alpha1AT deficiency.
Consequences of fluid loss in patients treated with ACE inhibitors (1987)

Three patients are described in whom haemodynamic collapse and acute renal failure occurred following intercurrent gastrointestinal fluid loss during treatment with an angiotensin converting-enzyme inhibitor. The possible consequences of blockade of the formation of angiotensin II during fluid loss are discussed.
Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes. (1978)

Peripheral blood monocytes incubated in a serum-free medium degraded serum amyloid A (SAA) protein along three pathways. Of 20 normal subjects, 8 degraded SAA completely with no detectable intermediates. Eight subjects transiently produced an amyloid A (AA)-like intermediate which comigrated on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (PAGE) with tissue AA protein and reacted with antisera to AA, whereas four subjects yielded a persistent AA-like intermediate on PAGE. This group also failed to degrade tissue AA protein. Cells from 10 patients with amyloidosis fell into the second group. The responsible enzymes appear to be serine proteases because they are inhibited by disopropyl fluorophosphate. They were not affected by epsilon-amino caproic acid, L-1-tosylamide-2-phenylethyl chloromethyl ketone, or N-alpha-p-tosyl-L-lysine chlormethyl ketone. It appears possible that the enzymes are associated with the outer membrane of the cell because only a small fraction of the activity is secreted into the medium and because enzyme activity remains after fixation of the cells with glutaraldehyde which completely stops phagocytosis. Perhaps differences in patterns of proteolysis may play a role in the predisposition to amyloidosis.
Churn prediction for high-value players in casual social games (2014)

Predicting when players will leave a game creates a unique opportunity to increase players' lifetime and revenue contribution. Players can be incentivized to stay, strategically cross-linked to other games in the company's portfolio or, as a last resort, be passed on to other companies through in-game advertisement. This paper focuses on predicting churn for highvalue players of casual social games and attempts to assess the business impact that can be derived from a predictive churn model. We compare the prediction performance of four common classification algorithms over two casual social games, each with millions of players. Furthermore, we implement a hidden Markov model to explicitly address temporal dynamics. We find that a neural network achieves the best prediction performance in terms of area under curve (AUC). In addition, to assess the business value of churn prediction, we design and implement an A/B test on one of the games, using free in-game currency as an incentive to retain players. Test results indicate that contacting players shortly before the predicted churn event substantially improves the effectiveness of communication with players. They further show that giving out free in-game currency does not significantly impact the churn rate or monetization of players. This suggests that players can only be retained by remarkably changing their gameplay experience ahead of the churn event and that cross-linking may be the more effective measure to deal with churning players.
Tissue identification using inverse Finite Element analysis of rolling indentation (2009)

The authors have recently proposed the method of rolling indentation over soft tissue to rapidly identify soft tissue properties for localization and detection of tissue abnormalities, with the aim of compensating for the loss of haptics information experienced during robotic-assisted minimally invasive surgery (RMIS). This paper investigates the concept of rolling indentation using finite element modeling. To obtain ground truth data, rolling indentation experiments are conducted on a silicone phantom which contains three simulated tumours. The tissue phantom is modeled as hyperelastic material using ABAQUStrade. The identification of tumours includes two parts: firstly, when the spatial location of tumour is known, identify the tumour's mechanical properties (initial shear modulus); secondly if the mechanical properties of tumour are known, identify the tumour's spatial location. The results show that the proposed method can identify information of tumours accurately and robustly. The identified tumour mechanical properties and tumour locations are in good agreement with experimental measurements.
Effect of Heparin on the Inhibition of Factor Xa by Tissue Factor Pathway Inhibitor: A Segment, Gly212-Phe243, of the Third Kunitz Domain Is a Heparin-Binding Site (1995)

Tissue factor pathway inhibitor (TFPI) inhibits the tissue factor--factor VIIa complex and factor Xa with its first and second Kunitz domains (K1 and K2), respectively. The inhibitory activity is enhanced by heparin, and the C-terminal basic part has been shown to be a heparin-binding site (HBS-1). To characterize and localize a second heparin-binding site (HBS-2), we studied the effect of heparin on the inhibitory activity of two forms of recombinant human TFPI, the full-length TFPI (rTFPI), and TFPI lacking the C-terminal basic part (rTFPI-C), by assaying the inhibition of human factor Xa. rTFPI-C inhibited factor Xa with an initial Ki of 6.79 nM in the absence of Ca2+ and 22.3 nM in the presence of 5 mM CaCl2. Heparin decreased the initial Ki to 1.79 nM in the absence of Ca2+ and 2.68 nM in the presence of 5 mM CaCl2, indicating the presence of HBS-2 in rTFPI-C. The dissociation constant for the binding of HBS-2 with heparin was determined to be 830 nM using fluorescein-labeled heparin and rTFPI-C. Heparin enhanced the inhibitory activity of a fragment consisting of the K2 and K3 domains, but it did not stimulate the inhibitory activity of the K2 domain. A synthetic peptide mimicking from Gly212 to Phe243 in the K3 domain reduced the effect of heparin on the inhibition by rTFPI-C and rTFPI. These results defined the location of HBS-2 in the basic region of the K3 domain between Gly212 and Phe243.
Plasma marinobufagenin-like and ouabain-like immunoreactivity during saline volume expansion in anesthetized dogs (1996)

These results show the presence of marinobufagenin-like immunoreactive substance in dog plasma and suggest that mammalian EDLF may have a bufodienolide nature. Endogenous marinobufagenin-like immunoreactive substance, which is likely to cross-react with antidigoxin antibody, is involved in the natriuretic and positive inotropic responses to plasma volume expansion.
For want of a bit the user was lost: Cheap user modeling (1996)

The more a computer knows about a user, the better it can serve that user. But there are different styles, and even philosophies, of how to teach our computers about us-about our habits, interests, patterns, and preferences. "Cheap" user modeling, the subject of this essay, simply means ascertaining a few bits of information about each user, processing that information quickly, and providing the results to applications, all without intruding upon the user's consciousness. In short, there are techniques for personalization that can-and should-be built into today's systems. Like most journal papers, this is a description of an existing system: DOPPELGÄNGER. But it is also an exhortation for readers to incorporate the described techniques and philosophy into their own systems.
Exploring Identity and Assimilation: Research and Interpretive Poems (2008)

Through the presentation of traditional qualitative and poetic data, this article explores the experience of a Native American woman coming to terms with her bi-racial identity and issues related to assimilation. Data is presented in three different ways, each with varied implications for qualitative and expressive arts researchers. First, data is presented as an in-depth qualitative interview with interpretive comments. Next, the authors present a research poem that utilizes the subject's exact words in compressed form. This is followed by two interpretative, creative poems that reflect the authors' attempts at capturing the essence of the subject's experience. The strengths and limitations of each of these methods are assessed. The article further discusses the implications of using poems and other expressive arts as data. URN: urn:nbn:de:0114-fqs040254
Field reversed configurations (1988)

The review is devoted to field reversed configurations and to the related field reversed mirrors; both are compact toroids with little or no toroidal magnetic field. Experimental and theoretical results on the formation, equilibrium, stability and confinement properties of these plasmas are presented. Although they have been known for about three decades, field reversed configurations have been studied intensively only in recent years. This renewed interest is due to the unusual fusion reactor potential of these high beta plasmas and also to their surprising macroscopic stability. At the present time, field reversed configurations appear to be completely free of gross instabilities and show relatively good confinement. The primary research goal for the near future is to retain these favourable properties in a less kinetic regime. Other important issues include the development of techniques for slow formation and stability, and a clearer assessment of the confinement scaling laws.
Conformations of End-Tethered DNA Molecules on Gold Surfaces: Influences of Applied Electric Potential, Electrolyte Screening, and Temperature (2010)

We describe the behavior of 72mer oligonucleotides that are end-tethered to gold surfaces under the influence of applied electric fields. The DNA extension is measured by fluorescence energy transfer as a function of the DNA hybridization state (single- and double-stranded), the concentration of monovalent salt in solution (100 microM to 1 M NaCl), the applied electrode potential (-0.6 to +0.1 V vs Pt), and the temperature (1 to 50 degrees C). At high ionic strength, the DNA conformations are very robust and independent of the applied electrode potential and temperature variations. In solutions of medium ionic strength, the DNA conformation can be manipulated efficiently by applying bias potentials to the Au electrodes. The molecules are repelled at negative potentials and attracted to the surface at positive potentials. The conformation transition occurs abruptly when the electrode bias is swept by merely 0.1 V across the transition potential, which shifts negatively when the salinity is decreased. The behavior can be understood by electrostatic screening arguments and, in the case of single-stranded DNA, when secondary structures are taken into account. At low ionic strength, the experiments reveal an intriguing temperature-dependent stiffening of single-stranded DNA, which can be rationalized by combining counterion condensation theory with the Odjik-Skolnick-Fixman description of the electrostatic persistence length and the unstacking of bases at elevated temperatures.
Ferric carboxymaltose improved symptoms and quality of life in patients with chronic heart failure and iron deficiency (2010)

ACP Journal Club20 April 2010Ferric carboxymaltose improved symptoms and quality of life in patients with chronic heart failure and iron deficiencyRobb D. Kociol, MD, L. Kristin Newby, MD, MHSRobb D. Kociol, MDDuke Clinical Research Institute, Durham, North Carolina, USA (R.D.K., L.K.N.)Search for more papers by this author, L. Kristin Newby, MD, MHSDuke Clinical Research Institute, Durham, North Carolina, USA (R.D.K., L.K.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-8-201004200-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAnker SD, Comin Colet J, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361:2436-48. https://pubmed.ncbi.nlm.nih.gov/19920054Clinical Impact RatingsCardiology: Author, Article, and Disclosure InformationAffiliations: Duke Clinical Research Institute, Durham, North Carolina, USA (R.D.K., L.K.N.)This article was published at Annals.org on 6 April 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron Status and Analysis of Efficacy and Safety of Ferric Carboxymaltose Treatment in Patients with Inflammatory Bowel DiseaseHeart failure in 2010 20 April 2010Volume 152, Issue 8Page: JC4-5KeywordsAnemiaHeart failureHemoglobinHospitalizationsIntent to treat analysisIron deficiencyIron deficiency anemiaLeft ventricular ejection fractionQuality of lifeSafety ePublished: 20 April 2010 Issue Published: 20 April 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cellular interactions in marrow-grafted patients. I. Impairment of cell-mediated lympholysis associated with graft-vs-host disease and the effect of interleukin 2. (1983)

Forty patients with hematologic malignancy or aplastic anemia were given allogeneic marrow after conditioning with high-dose cyclophosphamide alone or in combination with total body irradiation. Between 28 and 3857 days after transplantation, their peripheral blood mononuclear leukocytes were tested for reactivity in indirect cell-mediated lympholysis against normal leukocytes from unrelated individuals, and the results were compared to those with cells from their healthy marrow donors. An impairment of cell-mediated lympholysis was found with cells from most patients with acute and chronic graft-vs-host disease (GVHD) whereas cells from most short-term and long-term patients without GVHD had cell-mediated lympholysis reactivity comparable to that of cells from the marrow donors. When interleukin 2 was added to the mixed leukocyte cultures during the sensitization phase, the impaired cell-mediated immunity of cells from most short-term patients with acute GVHD, but not that of cells from most patients with chronic GHVD, could be restored to normal levels. These results suggest the impairment of cell-mediated immunity seen in cells of short-term patients with acute GVHD is attributable to helper cell defects or to ineffective communication between antigen-presenting cells and helper T cells. The impairment in cell-mediated immunity seen in patients with chronic GVHD, however, may reside on the effector cells (or their precursors) or may be due to the presence of suppressor cell activity.
The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder (2005)

Ileo-colonic LNH is a characteristic pathological finding in children with ASD and gastrointestinal symptoms, and is associated with mucosal inflammation. Differences in age at colonoscopy and diet do not account for these changes. The data support the hypothesis that LNH is a significant pathological finding in ASD children.
Influence of ionic surfactants on the viscoelastic properties of zwitterionic surfactant solutions (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfluence of ionic surfactants on the viscoelastic properties of zwitterionic surfactant solutionsH. Hoffmann, A. Rauscher, M. Gradzielski, and S. F. SchulzCite this: Langmuir 1992, 8, 9, 2140–2146Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/la00045a013https://doi.org/10.1021/la00045a013research-articleACS PublicationsRequest reuse permissionsArticle Views657Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts