gebhart/patrepeval huggingface dataset:
Autogenous osteochondral morselised grafts for full thickness osteochondral defects in the knee joints of pigs. (2001)

The aim of this study is to firstly ascertain the survival of autogenously grafted morselised cartilage for full thickness osteochondral defects in knee joints of pigs. Secondly, it is to determine the quality of the grafted cartilage that survives and to score to it based on a recognised and tested system of indices and thirdly, to recognise, if any, the potential for reconstitution of the osteochondral junction. Two groups of five pigs were followed up for six and 12 weeks. Similar osteochondral defects were created in the medial condyles of both knees with the right medial femoral condyle defect filled with graft and the left used as control and filled with gel foam. At the end of the study period, an independent pathologist assessed the defects macroscopically and microscopically with an accepted and comparable histological scoring system. Macroscopically, there was better filling of the defect and restoration of bony contour in the grafted group compared to the control. Microscopically, at six weeks, filling of the defect, nature of predominant tissue, matrix staining and nature of cells all showed significantly better histological score than the control using the Mann-Whitney U test at the level of significance of p<0.05. At 12 weeks, in addition to the above, the reconstitution of osteochondral junction also showed a significantly better score. Comparing the test groups at six and 12 weeks, the reconstitution of the osteochondral junction was significantly better at 12 weeks. In conclusion, the autogenous osteochondral morselised graft persisted as mature hyaline cartilage with good histological score at six weeks with significantly better reconstitution of osteochondral junction occurring at 12 weeks. The use of morselised graft allows for the inclusion of bone graft which possibly allows for larger amounts of donor tissue and thus the possibility of treating larger defects. In the human model the donor site would be the non-weight bearing surfaces of the knee such as the intercondylar notch as described by Walgenbach A and Stone KR at the 1997 Annual Meeting of the American Academy of Orthopaedic Surgeons in San Francisco.
Palladium-Catalyzed Head-to-Head Telomerization of Isoprene with Amines (2000)

The palladium complex of tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP) catalyzes the telomerization of isoprene with several secondary amines with unprecedented levels of selectivity for the head-to-head isomer. A mechanism based on stereoelectronic control by a Pd−monophosphine adduct is proposed.
Discrimination of bacterial lipoproteins by Toll-like receptor 6 (2001)

Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of a lipoylated N-terminus. Most BLP are triacylated at the N-terminus cysteine residue, but mycoplasmal macrophage-activating lipopeptide-2 kD (MALP-2) is only diacylated. Here we show that TLR6-deficient (TLR6(-/-)) cells are unresponsive to MALP-2 but retain their normal responses to lipopeptides of other bacterial origins. Reconstitution experiments in TLR2(-/-) TLR6(-/-) embryonic fibroblasts reveal that co-expression of TLR2 and TLR6 is absolutely required for MALP-2 responsiveness. Taken together, these results show that TLR6 recognizes MALP-2 cooperatively with TLR2, and appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria.
Increasing Incidence of Type 1 Diabetes in Youth (2013)

The incidence of type 1 diabetes is rising among children in Philadelphia. The incidence rate has increased by 29% since the 1985-1989 cohort. The most marked increases were among white children ages 10-14 years and black children ages 0-4 years. The incidence of type 1 diabetes is 18 times higher than that of type 2 in white children but only 1.6 times higher in black children.
Evaluating PACS Success: A Multidimensional Model (2005)

A picture archiving and communications system (PACS) is an integrated workflow system for managing images and related data which is designed to streamline operations throughout the whole patient care delivery process. PACS has become a mature technology over the past few years and has been widely implemented in several developed countries. Evaluation of PACS success is a major challenge to healthcare organizations. A review of previous PACS research suggests a fragmented and focused evaluation approach, thus offering limited discussion of comprehensive views of PACS success or systematic and practical guidance to its evaluations. Based on two prevalent information systems success models, this paper proposes and describes an integrated framework for evaluating PACS success in hospital settings. It details the validation process of the proposed model and its related measurement instrument at a large tertiary-care teaching hospital in Canada. Future research directions that extend the proposed research model are highlighted.
Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. (2003)

HSPPC-96 vaccination after resection of colorectal liver metastases is safe and elicits a significant increase in CD8+ T-cell response against colon cancer. In this limited number of patients, two-year OS and DFS were significantly improved in subjects with postvaccination antitumor immune response, independently from other clinical prognostic factors.
Efficiently Detecting All Dangling Pointer Uses in Production Servers (2006)

In this paper, we propose a novel technique to detect all dangling pointer uses at run-time that is efficient enough for production use in server codes. One idea (previously used by Electric Fence, PageHeap) is to use a new virtual page for each allocation of the program and rely on page protection mechanisms to check dangling pointer accesses. This naive approach has two limitations that makes it impractical to use in production software: increased physical memory usage and increased address space usage. We propose two key improvements that alleviate both these problems. First, we use a new virtual page for each allocation of the program but map it to the same physical page as the original allocator. This allows using nearly identical physical memory as the original program while still retaining the dangling pointer detection capability. We also show how to implement this idea without requiring any changes to the underlying memory allocator. Our second idea alleviates the problem of virtual address space exhaustion by using a previously developed compiler transformation called Automatic Pool Allocation to reuse many virtual pages. The transformation partitions the memory of the program based on their lifetimes and allows us to reuse virtual pages when portions of memory become inaccessible. Experimentally we find that the run-time overhead for five unix servers is less than 4%, for other unix utilities less than 15%. However, in case of allocation intensive benchmarks, we find our overheads are much worse (up to 11x slowdown).
The Inhalation of Drugs: Advantages and Problems (2005)

Inhalation is a very old method of drug delivery, and in the 20th century it became a mainstay of respiratory care, known as aerosol therapy. Use of inhaled epinephrine for relief of asthma was reported as early as 1929, in England. An early version of a dry powder inhaler (DPI) was the Aerohalor, used to administer penicillin dust to treat respiratory infections. In the 1950s, the Wright nebulizer was the precursor of the modern hand-held jet-venturi nebulizer. In 1956, the first metered-dose inhaler (MDI) was approved for clinical use, followed by the SpinHaler DPI for cromolyn sodium in 1971. The scientific basis for aerosol therapy developed relatively late, following the 1974 Sugarloaf Conference on the scientific basis of respiratory therapy. Early data on the drug-delivery efficiency of the common aerosol delivery devices (MDI, DPI, and nebulizer) showed lung deposition of approximately 10-15% of the total, nominal dose. Despite problems with low lung deposition with all of the early devices, evidence accumulated that supported the advantages of the inhalation route over other drug-administration routes. Inhaled drugs are localized to the target organ, which generally allows for a lower dose than is necessary with systemic delivery (oral or injection), and thus fewer and less severe adverse effects. The 3 types of aerosol device (MDI, DPI, and nebulizer) can be clinically equivalent. It may be necessary to increase the number of MDI puffs to achieve results equivalent to the larger nominal dose from a nebulizer. Design and lung-deposition improvement of MDIs, DPIs, and nebulizers are exemplified by the new hydrofluoroalkane-propelled MDI formulation of beclomethasone, the metered-dose liquid-spray Respimat, and the DPI system of the Spiros. Differences among aerosol delivery devices create challenges to patient use and caregiver instruction. Potential improvements in aerosol delivery include better standardization of function and patient use, greater reliability, and reduction of drug loss.
Effects of Sibutramine Plus Orlistat in Obese Women Following 1 Year of Treatment by Sibutramine Alone: A Placebo‐Controlled Trial (2000)

These results must be interpreted with caution because of the study's small sample size. The findings, however, suggest that the combination of sibutramine and orlistat is unlikely to have additive effects that will yield mean losses > or =15% of initial weight, as desired by many obese individuals.
Observing Majorana bound states of Josephson vortices in topological superconductors (2011)

In recent years there has been an intensive search for Majorana fermion states in condensed matter systems. Predicted to be localized on cores of vortices in certain nonconventional superconductors, their presence is known to render the exchange statistics of bulk vortices non-abelian. Here we study the equations governing the dynamics of phase solitons (fluxons) in a Josephson junction in a topological superconductor. We show that the fluxon will bind a localized zero energy Majorana mode and will consequently behave as a non-abelian anyon. The low mass of the fluxon, as well as its experimentally observed quantum mechanical wave-like nature, will make it a suitable candidate for vortex interferometry experiments demonstrating non-abelian statistics. We suggest two experiments that may reveal the presence of the zero mode carried by the fluxon. Specific experimental realizations will be discussed as well.
RNAi: A New Technology in the Post-Genomic Sequencing Era (2001)

The complete genome sequences and huge numbers of predicted gene sequences from many complex organisms are available. Reverse-genetic analyses of these organisms will now be necessary to understand what all these genes are doing and how their functions interact. RNAi technology is very useful in this regard for studying gene function, not only in these model organisms, but also in the organisms previously considered not to be amenable to genetic analysis. This treatment reviews the discovery of RNAi, advances in the study of the mechanisms by which this material impinges on gene-product expressions, and technical improvements that will allow RNAi to be applied to a wide variety of organisms.
A fast approach for integrating ORB descriptors in the bag of words model (2013)

In this paper we propose to integrate the recently introduces ORB descriptors in the currently favored approach for image classification, that is the Bag of Words model. In particular the problem to be solved is to provide a clustering method able to deal with the binary string nature of the ORB descriptors. We suggest to use a k-means like approach, called k-majority, substituting Euclidean distance with Hamming distance and majority selected vector as the new cluster center. Results combining this new approach with other features are provided over the ImageCLEF 2011 dataset.
Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects. (1994)

Although both spontaneous and stimulated GH secretion undergo an age-related decline, the secretory capacity of somatotrope cells is preserved in human aging. In the present study we compared the GH responses to hexarelin, GHRH, and the combined administration of hexarelin and GHRH or arginine in young and elderly subjects. Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups. The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg). The second group (6 young and 8 elderly subjects) was administered single iv injections of hexarelin (2 micrograms/kg) or hexarelin (2 micrograms/kg) plus arginine (0.5 g/kg) during 2 different treatment sessions. In both groups basal IGF-I levels in the elderly were lower than those in young subjects (114.5 +/- 18.7 vs. 211.5 +/- 19.1 micrograms/L; P < 0.001). In the first group the GH response to hexarelin was greater in young compared to elderly subjects (area under the curve from 0-120 = 4849 +/- 601 vs. 2112 +/- 683 micrograms.min/L; P < 0.001). GHRH elicited a lower GH response than that induced by hexarelin in both young (1455 +/- 102 micrograms/h.L; P < 0.02) and elderly subjects (563 +/- 87 micrograms/min.L; P < 0.02). GHRH potentiated the somatotrope response to hexarelin in both young (7725 +/- 503 micrograms/min.L; P < 0.02) and elderly subjects (3895 +/- 612 micrograms/min.L; P < 0.02), but to a lesser extent in the latter (P < 0.001). In the second group, the GH response induced by hexarelin was also higher in young subjects than in elderly subjects (4819 +/- 668 vs. 1649 +/- 459 micrograms/min.L; P < 0.001). The GH response to hexarelin was potentiated by arginine in elderly (4139 +/- 1057 micrograms/min. L; P < 0.001), but not in young subjects (4743 +/- 774 micrograms/min.L). This study shows that the maximal effective dose of hexarelin releases more GH than the maximal effective dose of GHRH in both normal young and elderly subjects. The effect of hexarelin on GH secretion is age dependent, and the GH response to the combined administration of hexarelin and GHRH was significantly higher in young subjects compared to elderly subjects. Arginine does not potentiate the GH response to hexarelin in young subjects, whereas it significantly enhances it in elderly subjects.(ABSTRACT TRUNCATED AT 400 WORDS)
Chemically bonded phosphate ceramics : cementing the gap between ceramics and cements. (2003)

of Energy. The U.S. Government retains for itself, and others acting on its behalf, a paid-up, nonexclusive, irrevocable worldwide license in said article to reproduce, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government. Invited paper for publication in Materials Technology.
A novel prokaryotic trans‐2‐enoyl‐CoA reductase from the spirochete Treponema denticola (2007)

An NADH-dependent trans-2-enoyl-CoA reductase (EC1.1.1.36) from the Gram negative spirochete Treponema denticola was identified, expressed and biochemically characterized. The recombinant protein is a monomeric enzyme with a molecular mass of 44 kDa with a specific activity of 43+/-4.8 U/mg (micromol mg(-1)min(-1)) and K(m) value of 2.7 microM for crotonoyl-CoA. This NADH-dependent trans-2-enoyl-CoA reductase represents the first enzymatically characterized member of a prokaryotic protein family involved in a fatty acid synthesis pathway that is distinct from the familiar fatty acid synthase system.
Motor dysfunction in mildly demented AD individuals without extrapyramidal signs (1999)

These results indicate that AD alone, in the absence of clinically confirmed extrapyramidal dysfunction, is associated with motor slowing in a stage-dependent manner. It remains to be determined whether this motor slowing represents a general characteristic of mild AD or indicates other neuropathology such as PD or the Lewy body variant of AD.
Optimal x‐ray spectra for screen‐film mammography (1981)

Theoretical and experimental techniques have been used to study optimal x-ray for screen-film mammography. A simple model of mammographic imaging predicts optimum x-ray energies which are significantly higher than the K-characteristic energies of Mo. A subjective comparison of x-ray spectra from Mo-anode and W-anode tubes indicates that spectra produced by a W-anode tube filtered with materials of atomic number just above that of Mo are more suitable for screen-film mammography than spectra produced by the Mo-anode/Mo-filter system. The imaging performance of K-edge filtered, W-anode tube spectra was compared to the performance of Mo-anode spectra using phantom measurements and mastectomy specimen radiography. It was shown that optimal W-anode spectra can produce equal contrast with an exposure reduction of a factor of two to three, a dose reduction of a factor of two, and equal or reducing tube loading, compared to Mo-anode spectra. A computer simulation was carried out to extend the initial, monoenergetic theory to the case of real, polychromatic sources. The effects of varying filter material and thickness, tube operating potential, and breast thickness were all studied. Since W-anode x-ray tubes are considered to be better for Xerox mammography than Mo-anode tubes, this study has shown that both Xerox and screen-film techniques can be performed optimally with a single, properly designed, W-anode x-ray tube.
New Oxidative Degradation Method for Producing Fatty Acids in High Yields and High Selectivity from Low-Rank Coals (1996)

Oxidation of low-rank coals using hydrogen peroxide at low temperature under ambient pressure is a promising method of producing small molecule fatty acids in high yield and in high selectivity. Five low-rank coals (C% = 65.1−74.7 on daf basis) served to test the validity of the method. When Argonne Premium Beulah Zap lignite was oxidized with 20 volumes of 30% H2O2 aqueous solution for 24 h at 60 °C, the carbon conversion to water-soluble organics reached 0.71. About a half of the water-soluble organics were small molecules: methanol, formic acid, acetic acid, glycolic acid, and malonic acid. The high yields of these compounds are closely related to the structure of low-rank coals. Obtaining these products in such high yield and high selectivity under mild reaction conditions may give us a new route for utilizing low-rank coals.
Recent Advances in Embryonic Wound Healing (2000)

The observation that mammalian embryos can heal wounds perfectly, without apparent scar formation was first made more than 20 years ago (1,2). This exciting finding has subsequently fueled much experimental work to determine the mechanisms whereby this phenomenon might occur, as well as to try and elucidate the differences between the processes occurring in the healing of adult and embryonic wounds.
A Versatile Tandem Catalysis Procedure for the Preparation of Novel Amino Acids and Peptides (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Versatile Tandem Catalysis Procedure for the Preparation of Novel Amino Acids and PeptidesMark J. Burk, Jeffrey R. Lee, and Jose P. MartinezCite this: J. Am. Chem. Soc. 1994, 116, 23, 10847–10848Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00102a085https://doi.org/10.1021/ja00102a085research-articleACS PublicationsRequest reuse permissionsArticle Views822Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Transgenic Expression of Single-Chain Anti-CTLA-4 Fv on β Cells Protects Nonobese Diabetic Mice from Autoimmune Diabetes (2009)

T cell-mediated immunodestruction of pancreatic beta cells is the key process responsible for both the development of autoimmune diabetes and the induction of rejection during islet transplantation. In this study, we investigate the hypothesis that transgenic expression of an agonistic, membrane-bound single-chain anti-CTLA-4 Fv (anti-CTLA-4 scFv) on pancreatic beta cells can inhibit autoimmune processes by selectively targeting CTLA-4 on pathogenic T cells. Strikingly, transgenic expression of anti-CTLA-4 scFv on pancreatic beta cells significantly protected NOD mice from spontaneous autoimmune diabetes. Interestingly, local expression of this CTLA-4 agonist did not alter the diabetogenic properties of systemic lymphocytes, because splenocytes from transgenic mice or their nontransgenic littermates equally transferred diabetes in NOD/SCID recipients. By analyzing the T cell development in anti-CTLA-4 scFv/Th1/Th2 triple transgenic mice, we found that beta cell-specific expression of CTLA-4 agonist did not affect the development of Th1/Th2 or CD4(+)CD25(+) regulatory T cells. Most strikingly, islets from transgenic mice inhibited T cell response to immobilized anti-CD3 in a T cell-islet coculture system, suggesting a trans-mediated inhibition provided by transgenic islets. Finally, transgenic islets implanted in diabetic recipients survived much longer than did wild-type islets, indicating a therapeutic potential of this genetically modified islet graft in autoimmune diabetes.