gebhart/patrepeval huggingface dataset:
Cooling techniques for computers (1991)

Air cooling techniques by natural convection forced and mixed convection cooling in computers forced convection and turbulence in thermal control liquid cooling for electronic equipment boiling and condensation as applied to direct cooling thermal conduction in microelectronic chips thermal design for microelectronic components theory and applications of constriction and spreading resistance concepts for microelectronic thermal management experimental methods for air cooling of electronic components system cooling design considerations for large mainframe computers survey of design approaches in Japanese computers.
Tumor-driven matrix invasion by infiltrating lymphocytes: involvement of the α1 integrin I-domain (1998)

Here we show that tumor cells (TC) from renal cancers regulate the migratory properties of autologous tumor-infiltrating lymphocytes (TIL), enhancing their ability to invade the extracellular matrix. A similar effect is exerted by human recombinant macrophage chemotactic protein 1 (MCP-1) and IL-8, chemokines known to increase T lymphocyte migration both across vascular endothelium and subendothelial matrix. We found that TC freshly derived from renal cell carcinoma surgical specimens constitutively secrete both IL-8 and MCP-1 and that TIL express both specific receptors. TIL matrix invasion elicited by TC is inhibited by the addition of neutralizing antisera specific for IL-8 and MCP-1, demonstrating the direct relationship between chemokine release by TC and TIL invasion. Of note, TIL invasion of the extracellular matrix requires the alpha1 integrin, which acts through its I-domain that is upregulated upon culture with MCP-1 and IL-8. Collectively, these findings suggest that TC may actively recruit TIL via the release of chemotactic factors that enhance an alpha1 integrin-mediated pathway of matrix invasion.
Structure from controlled motion (1996)

This paper deals with the recovery of 3D information using a single mobile camera in the context of active vision. First, we propose a general revisited formulation of the structure-from-known-motion issue. Within the same formalism, we handle various kinds of 3D geometrical primitives such as points, lines, cylinders, spheres, etc. We also aim at minimizing effects of the different measurement errors which are involved in such a process. More precisely, we mathematically determine optimal camera configurations and motions which lead to a robust and accurate estimation of the 3D structure parameters. We apply the visual servoing approach to perform these camera motions using a control law in closed-loop with respect to visual data. Real-time experiments dealing with 3D structure estimation of points and cylinders are reported. They demonstrate that this active vision strategy can very significantly improve the estimation accuracy.
Local Learning in RRAM Neural Networks with Sparse Direct Feedback Alignment (2019)

Neural networks utilizing non-volatile random access memory (NVM) exhibit excellent power reduction over traditional CMOS implementations. RRAM (resistive random access memory) is one such emerging memory technology offering low energy, good endurance, and a large analog conductance window. When implemented in a crossbar architecture, these networks are able to bypass the von-Neumann bottleneck by performing compute in-memory. This architecture works well for inference; however, training the network is far more challenging. Networks built using RRAM can be trained on-chip with gradient descent or off-chip where weights are transferred. Backpropagation, while effective in training von-Neumann architectures, is inefficient when memory and compute are partitioned together. Commonly referred to as the weight transport problem, each neuron's dependence on the weights and errors located deeper in the network requires reading the weights in each layer before computing and applying the error. This presents a key challenge in performing efficient on chip training for non von-Neumann architectures. In this work we demonstrate an alternative to backpropagation called sparse direct feedback alignment which bypasses the weight transport problem. We simulate crossbars of HfOx RRAM based on experimental data to explore the performance, area, and energy trade-offs of using bio-plausible algorithms on the MNIST and EMNIST datasets.
Arthroscopic shoulder stabilization using Mitek anchors (1995)

The purpose of this paper is to report our experience with an arthroscopic stabilization technique using bone anchors in the treatment of chronic unidirectional anterior-inferior shoulder instability. 30 of 32 patients (average age, 26 years) were followed for an average of 24 months (range 12 to 36). There were 28 patients with dislocations and four with subluxations. In the group of the dislocators five patients had more than 10 dislocations and 15 patients between one and seven (average three). In 68% a sport injury was the reason for the first dislocation. Due to the length of the labroligamentous detachment two to four anchors were used for stabilization. According to the criteria of Rowe, in the group of the subluxators (4) two had an excellent and two a good result. In the group of the dislocators (26) two patients dislocated their shoulder again after reconstruction without a new accident, one had a recurrent dislocation from significant trauma. Two of them had an open stabilization afterwards. Overall there were 53.9% excellent, 34.6% good and 11.5% poor results. In 50% there was no restriction of shoulder motion, 21% had a loss of external rotation of 5 degrees and 29% of 10 degrees. Arthroscopic shoulder stabilization with help of Mitek anchors seems to be a good method for treatment of chronic unidirectional anterior-inferior instabilities with less than 10 dislocations preoperatively. All patients, who suffered a spontaneous recurrent dislocation, had more than 10 dislocations before. In these cases this arthroscopic procedure is not suited to restore stability, even if a Bankart-lesion is present.
Isolation from Penicillium gilmanii of a Substance that Causes Leucocytosis in Rabbits. (1966)

A compound, chromatographi-cally homogeneous, was isolated from the metabolic products of P. gilmanii. This compound when injected into rabbits in quantities of from 0.001 μg to 10 μg per kg causes a leucocytosis without a concurrent increase in body temperature. The material is not toxic to mice when injected in milligram quantities. Preliminary analysis suggests a minimum molecular formula of C18H29-31NO9. The compound is apparently an enol, hence the name Leucogenenol is suggested for the compound.
New Wide-Area Algorithms for Detection and Mitigation of Angle Instability using Synchrophasors (2007)

Electric power system is undergoing major technological advances with many new installations of synchrophasors across the North American grid as well in power systems all over the world. Wide-area monitoring system (WAMS) in the Pacific Northwest and the Eastern Interconnection Phasor Project (EIPP) in the eastern grid are examples of such installations. Synchrophasors together with modern communication technology facilitate the monitoring of the current state of the power system including the phase angles of the bus voltages at critical buses in a time-synchronized fashion. The algorithms and the controller proposed in this paper detect the fast separation of phase angles among the critical areas automatically by using the synchrophasors, and proceed to mitigate the emerging angle instability by triggering suitable control action. Briefly, the algorithms initiate tripping of critical generators in the accelerating part of the system when necessary, and also initiate load shedding in the decelerating part of the system whenever necessary. The novelty of the algorithms is in the fact that all the decisions are made in real-time purely based on the wide-area synchrophasor measurements without any knowledge of the details of relay actions that may have resulted in the angle instability phenomenon.
Pilot study of ribavirin and interferon-beta for chronic hepatitis B. (1993)

Ribavirin is a nucleoside analog that inhibits the replication of many DNA and RNA viruses. To evaluate the efficacy of oral ribavirin, we randomly assigned 24 HBeAg-positive patients with chronic active hepatitis to a 12-wk course of treatment with 0.8 to 1.0 gm/ribavirin day, 3 mU interferon-beta three times a week intravenously or a combination of those drugs. Ribavirin, alone and in combination with interferon-beta, decreased hepatitis B virus levels in most patients, and mean serum hepatitis B virus DNA and DNA polymerase levels at the end of treatment were approximately half of baseline levels (p < 0.05). Interferon alone exerted the most inhibitory effect on hepatitis B virus activity (p < 0.01). During ribavirin treatment, changes in serum aminotransferase values varied considerably and the mean values did not change significantly, although interferon alone and the combination of interferon and ribavirin were associated with significant reductions in serum aminotransferase activities. Ribavirin was well tolerated, but we transiently reduced the dosage in two cases because of mild hemolytic anemia, although all patients completed the treatment schedule. The combination of interferon and ribavirin did not appear to result in greater toxicity. During the follow-up period (6 to 9 mo), HBeAg and hepatitis B virus DNA disappeared in one patient treated with ribavirin, in two treated with interferon and in two given the combination. These results indicate that ribavirin suppresses hepatitis B virus replication, although its effect is less than that of interferon, and that it may be useful as adjunctive therapy for chronic hepatitis B.(ABSTRACT TRUNCATED AT 250 WORDS)
Palladium-mediated coupling between organic disulfides and nucleic acid constituents (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-mediated coupling between organic disulfides and nucleic acid constituentsDon Bergstrom, Peter Beal, Adil Husain, Robert Lind, and Jeffrey JensonCite this: J. Am. Chem. Soc. 1989, 111, 1, 374–375Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00183a061https://doi.org/10.1021/ja00183a061research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Iron‐dependent regulation of the divalent metal ion transporter (2001)

The first step in intestinal iron absorption is mediated by the H(+)-coupled Fe(2+) transporter called divalent cation transporter 1/divalent metal ion transporter 1 (DCT1/DMT1) (also known as natural resistance-associated macrophage protein 2). DCT1/DMT1 mRNA levels in the duodenum strongly increase in response to iron depletion. To study the mechanism of iron-dependent DCT1/DMT1 mRNA regulation, we investigated the endogenous expression of DCT1/DMT1 mRNA in various cell types. We found that only the iron responsive element (IRE)-containing form, which corresponds to one of two splice forms of DCT1/DMT1, is responsive to iron treatment and this responsiveness was cell type specific. We also examined the interaction of the putative 3'-UTR IRE with iron responsive binding proteins (IRP1 and IRP2), and found that IRP1 binds to the DCT1/DMT1-IRE with higher affinity compared to IRP2. This differential binding of IRP1 and IRP2 was also reported for the IREs of transferrin receptors, erythroid 5-aminolevulinate synthase and mitochondrial aconitase. We propose that regulation of DCT1/DMT1 mRNA by iron involves post-transcriptional regulation through the binding of IRP1 to the transporter's IRE, as well as other as yet unknown factors.
Performance Evaluation of Task Pools Based on Hardware Synchronization (2005)

A task-based execution provides a universal approach to dynamic load balancing for irregular applications. Tasks are arbitrary units of work that are created dynamically at run-time and that are stored in a parallel data structure, the task pool, until they are scheduled onto a processor for execution. In this paper, we evaluate the performance of different task pool implementations for shared-memory computer systems using several realistic applications. We consider task pools with different data structures, different load balancing strategies and a specialized memory management. In particular, we use synchronization operations based on hardware support that is available on many modern micro-processors. We show that the resulting task pool implementations lead to a much better performance than implementations using Pthreads library calls for synchronization. The applications considered are parallel quicksort, volume rendering, ray tracing, and hierarchical radiosity. The target machines are an IBM p690 server and a SunFire 6800.
Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite (2005)

A proportion of atopic sheep develop typical airway remodelling changes after chronic allergen challenge, which is not directly related to the level of allergic inflammation.
‘Harvester’: a fast meta search engine of human protein resources (2004)

The service is freely available to the academic community at http://harvester.embl.de.
pS2 in Breast Carcinoma: Association with Steroid Hormone Receptor Status (1998)

Our study suggested that PR and pS2 protein may identify distinct subsets of estrogen receptor-positive breast carcinomas.
Bootstrap learning for place recognition (2002)

We present a method whereby a robot can learn to recognize places with high accuracy, in spite of perceptual aliasing (different places appear the same) and image variability (the same place appears differently). The first step in learning place recognition restricts attention to distinctive states identified by the map-learning algorithm, and eliminates image variability by unsupervised learning of clusters of similar sensory images. The clusters define views associated with distinctive states, often increasing perceptual aliasing. The second step eliminates perceptual aliasing by building a causal/topological map and using history information gathered during exploration to disambiguate distinctive states. The third step uses the labeled images for supervised learning of direct associations from sensory images to distinctive states. We evaluate the method using a physical mobile robot in two environments, showing high recognition rates in spite of large amounts of perceptual aliasing.
British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis (2019)

These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by the British Society of Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology groups as well as patient representatives from PSC Support. The guidelines aim to support general physicians, gastroenterologists and surgeons in managing adults with PSC or those presenting with similar cholangiopathies which may mimic PSC, such as IgG4 sclerosing cholangitis. It also acts as a reference for patients with PSC to help them understand their own management. Quality of evidence is presented using the AGREE II format. Guidance is meant to be used as a reference rather than for rigid protocol-based care as we understand that management of patients often requires individual patient-centred considerations.
Causality (2009)

Written by one of the preeminent researchers in the field, this book provides a comprehensive exposition of modern analysis of causation. It shows how causality has grown from a nebulous concept into a mathematical theory with significant applications in the fields of statistics, artificial intelligence, economics, philosophy, cognitive science, and the health and social sciences. Judea Pearl presents and unifies the probabilistic, manipulative, counterfactual, and structural approaches to causation and devises simple mathematical tools for studying the relationships between causal connections and statistical associations. Cited in more than 2,100 scientific publications, it continues to liberate scientists from the traditional molds of statistical thinking. In this revised edition, Judea Pearl elucidates thorny issues, answers readers' questions, and offers a panoramic view of recent advances in this field of research. Causality will be of interest to students and professionals in a wide variety of fields. Dr Judea Pearl has received the 2011 Rumelhart Prize for his leading research in Artificial Intelligence (AI) and systems from The Cognitive Science Society.
A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity (2001)

Many sequences in eukaryotic genomes have the potential to adopt a left-handed Z-DNA conformation. We used a previously described assay based on the binding of a mAb to Z-DNA to inquire whether Z-DNA is formed in the rat nucleolin (Ncl) gene in metabolically active, permeabilized nuclei. Using real-time PCR to measure Z-DNA formation, the potential Z-DNA sequence element Z1 [(CA)(10)(CG)(8)] in the promoter region was found to be enriched 571- to 4,040-fold in different cell lines, whereas Z2 [AC(GC)(5)CCGT(CG)(2)] in the first intron was enriched 12- to 34-fold. Ncl promoter activity was 1.5- to 16-fold stronger than that of the simian virus 40 promoter and enhancer. This activity was further increased 36-54% when Z1 was deleted. The inhibitory effect of Z1 on Ncl promoter activity was independent of location and orientation. The Ncl Z1 element is identical to the genetic marker D9Arb5. Five allelic variants of Z1 were identified by sequence analysis of genomic DNA from various rats. The two most common alleles differed significantly (up to 27%) in their capacity to inhibit Ncl promoter activity. This finding suggests that differences in Z-DNA formation by polymorphic dinucleotide repeats may be one of the factors contributing to genetic variation.
Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity (2000)

A number of tumor studies have indicated a link between CD4 help and the magnitude and persistence of CTL activity; however, the mechanisms underlying this have been largely unclear. To evaluate and determine the mechanisms by which CD4(+) T cells synergize with CD8(+) T cells to prevent tumor growth, we used the novel technique of monitoring in vivo CTL by labeling target cells with CFSE. This approach was supported by the direct visualization of CTL using peptide-MHC tetramers to follow tumor-specific T cells. The data presented demonstrate that while cotransfer of Ag-specific CD4(+) T cells was not required for the generation of CTLs, because adoptive transfer of CD8(+) T cells alone was sufficient, CD4(+) T cells were required for the maintenance of CD8(+) T cell numbers. Our data suggest that there is a correlation among the number of CD8(+) T cells, in vivo CTL function, and IFN-gamma production, with no evidence of a partial or nonresponsive phenotype among tetramer-positive cells. We also show that CD4(+) T cells are required for CD8(+) T cell infiltration of the tumor.
The Reduction of Sulfones to Sulfides (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reduction of Sulfones to SulfidesF. G. Bordwell and W. H. McKellinCite this: J. Am. Chem. Soc. 1951, 73, 5, 2251–2253Publication Date (Print):May 1, 1951Publication History Published online1 May 2002Published inissue 1 May 1951https://pubs.acs.org/doi/10.1021/ja01149a096https://doi.org/10.1021/ja01149a096research-articleACS PublicationsRequest reuse permissionsArticle Views2495Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tannins and related compounds. XL. Revision of the structures of punicalin and punicalagin, and isolation and characterization of 2-O-galloylpunicalin from the bark of Punica granatum L. (1986)

The structures of punicalin and punicalagin, isolated from the bark of Punica granatum L. (pomegranate), have been revised to 4, 6-(S, S)-gallagyl-D-glucose (1) and 2, 3-(S)-hexahydroxy-diphenoyl-4, 6-(S, S)-gallagyl-D-glucose (2), respectively, on the basis of chemical and spectroscopic evidence. In addition, a new hydrolyzable tannin, 2-O-galloyl-4, 6-(S, S)-gallagyl-D-glucose (3) was isolated from the same plant source, and characterized.
Network reconnaissance, attack, and defense laboratories for an introductory cyber-security course (2013)

Cyber-security is an area in which much curriculum development is taking place; it is important that such efforts be evaluated and shared. We describe three laboratories developed at the United States Naval Academy (USNA) for use in its fundamentals of cyber-security course. All three labs are conducted in a sandboxed virtual environment. Detailed instructor notes, student instructions, worksheets, grading guidance and supporting course software were developed for these labs. In this paper we share our experiences with these labs, assessment and evaluation material, and lessons learned so that others might benefit from our work.
Modified-Release Drug Delivery Technology (2007)

Modified-release drug delivery technology , Modified-release drug delivery technology , کتابخانه مرکزی دانشگاه علوم پزشکی تهران