gebhart/patrepeval huggingface dataset:
Properties of crystalline In–Ga–Zn-oxide semiconductor and its transistor characteristics (2014)

We report, in this paper, that crystalline In–Ga–Zn-oxide (IGZO) can be formed over an amorphous surface or over an uneven surface by a sputtering process at lower than 500 °C through the purification of IGZO. Crystalline IGZO, in which no clear grain boundary is observed, shows c -axis alignment but random a - and b -axis orientations without alignment. This crystal morphology differs from other morphologies that have been known thus far, such as single crystal and polycrystal morphologies. Our model for understanding the formation of this crystal morphology [ c -axis-aligned crystal (CAAC)] is also discussed. Upon thermal annealing of a deposited film at lower than 500 °C, nanocrystal regions remaining in the CAAC can be converted into the CAAC structure. Accordingly, I off can be at the yA/µm (10 −24 A/µm) level at 85 °C. It has been proven that by utilizing normally-off characteristics even with L / W = 40 nm/40 nm (actual size: L / W = 68 nm/34 nm), the fabrication of a three-dimensional (3D) LSI with a 3D oxide semiconductor/Si hybrid structure is feasible.
Local Feedback in Full-Text Retrieval Systems (1977)

article Free AccessLocal Feedback in Full-Text Retrieval Systems Authors: R. Attar Department of Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel Department of Applied Mathematics, The Weizmann Institute of Science, Rehovot, IsraelView Profile , A. S. Fraenkel Department of Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel Department of Applied Mathematics, The Weizmann Institute of Science, Rehovot, IsraelView Profile Authors Info & Claims Journal of the ACMVolume 24Issue 3July 1977 pp 397–417https://doi.org/10.1145/322017.322021Published:01 July 1977Publication History 186citation1,216DownloadsMetricsTotal Citations186Total Downloads1,216Last 12 Months56Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
In vitro and in vivo Performance and Lifetime of Perfluorinated Ionomer-Coated Glucose Sensors after High-Temperature Curing (1994)

In this paper we report that curing at 120 degrees C can be used to improve the in vivo durability of a miniaturized glucose sensor with an outer coating of the Dupont perfluorinated ionomer, Nafion. Sensors based on glucose oxidase trapped in an albumin/glutaraldehyde matrix were able to withstand curing at 120 degrees C without noticeable change in electrode sensitivity (+/- 22% SD). Curing above 120 degrees C caused a gradual decline in sensitivity, with no sensitivity seen at 170 degrees C. Curing Nafion at 120 degrees C eliminated ascorbic acid and urea interferences and improved selectivity for glucose against uric acid and acetaminophen, compared to room temperature-cured Nafion coatings. The Nafion film reduced O2 demand by the sensor, so the signal was O2 independent across a partial pressure range of 8-140 mmHg. Several of the fully assembled, heat-cured, needle-type glucose sensors remained functional for at least 10 days after subcutaneous implantation in dogs, without degradation of their sensitivity (average 3 nA/mM in vivo at 37 degrees C and 6 nA/mM in vitro at 37 degrees C).
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation (2004)

Complement activation with formation of biologically potent mediators like C5a and the terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and tissue damage in a number of autoimmune and inflammatory conditions. A particular role for complement in the ischaemia/reperfusion injury of the heart, skeletal muscle, central nervous system, intestine and kidney has been suggested from animal studies. Previous experiments in C3 and C4 knockout mice suggested an important role of the classical or lectin pathway in initiation of complement activation during intestinal ischaemia/reperfusion injury while later use of factor D knockout mice showed the alternative pathway to be critically involved. We hypothesized that alternative pathway amplification might play a more critical role in classical pathway-induced C5 activation than previously recognized and used pathway-selective inhibitory mAbs to further elucidate the role of the alternative pathway. Here we demonstrate that selective blockade of the alternative pathway by neutralizing factor D in human serum diluted 1 : 2 with mAb 166-32 inhibited more than 80% of C5a and TCC formation induced by solid phase IgM and solid- and fluid-phase human aggregated IgG via the classical pathway. The findings emphasize the influence of alternative pathway amplification on the effect of initial classical pathway activation and the therapeutic potential of inhibiting the alternative pathway in clinical conditions with excessive and uncontrolled complement activation.
Type V Collagen Controls the Initiation of Collagen Fibril Assembly (2004)

Vertebrate collagen fibrils are heterotypically composed of a quantitatively major and minor fibril collagen. In non-cartilaginous tissues, type I collagen accounts for the majority of the collagen mass, and collagen type V, the functions of which are poorly understood, is a minor component. Type V collagen has been implicated in the regulation of fibril diameter, and we reported recently preliminary evidence that type V collagen is required for collagen fibril nucleation (Wenstrup, R. J., Florer, J. B., Cole, W. G., Willing, M. C., and Birk, D. E. (2004) J. Cell. Biochem. 92, 113-124). The purpose of this study was to define the roles of type V collagen in the regulation of collagen fibrillogenesis and matrix assembly. Mouse embryos completely deficient in pro-alpha1(V) chains were created by homologous recombination. The col5a1-/- animals die in early embryogenesis, at approximately embryonic day 10. The type V collagen-deficient mice demonstrate a virtual lack of collagen fibril formation. In contrast, the col5a1+/- animals are viable. The reduced type V collagen content is associated with a 50% reduction in fibril number and dermal collagen content. In addition, relatively normal, cylindrical fibrils are assembled with a second population of large, structurally abnormal collagen fibrils. The structural properties of the abnormal matrix are decreased relative to the wild type control animals. These data indicate a central role for the evolutionary, ancient type V collagen in the regulation of fibrillogenesis. The complete dependence of fibril formation on type V collagen is indicative of the critical role of the latter in early fibril initiation. In addition, this fibril collagen is important in the determination of fibril structure and matrix organization.
A short sequence, within the amino acid tandem repeat of a cancer‐associated mucin, contains immunodominant epitopes (1989)

The polymorphic epithelial mucin (PEM) appears to be the target molecule for many monoclonal antibodies (MAbs) which react with tumour-associated and epithelium-specific antigens. PEM contains a large domain made up of 20 amino-acid tandem repeats which are highly immunodominant as many of the antibodies reactive with this molecule recognize epitopes within this area. Using overlapping peptide octamers, we have precisely mapped the epitopes of 4 MAbs reactive with the tandem repeats including one, SM-3, which shows enhanced tumour specificity. We report that the core of the SM-3 epitope corresponds to the continuous amino acid sequence Pro-Asp-Thr-Arg-Pro. We also show that the epitopes recognized by 3 other antibodies, which show reactivity with normal and malignant tissues, map to within this area of the tandem repeat. However, none of these epitopes contain the proline found at the amino end of the SM-3 determinant. These results are consistent with the idea that, in the cancer-associated mucin, premature termination of the carbohydrate side-chains results in the exposure of the SM-3 epitope.
Laser beam combining for high-power, high-radiance sources (2005)

Beam combining of laser arrays with high efficiency and good beam quality for power and radiance (brightness) scaling is a long-standing problem in laser technology. Recently, significant progress has been made using wavelength (spectral) techniques and coherent (phased array) techniques, which has led to the demonstration of beam combining of a large semiconductor diode laser array (100 array elements) with near-diffraction-limited output (M/sup 2//spl sim/1.3) at significant power (35 W). This paper provides an overview of progress in beam combining and highlights some of the tradeoffs among beam-combining techniques.
Synthesis and Biologically Relevant Properties of Polyphosphazene Polyacids (2004)

Polyphosphazene polyacids show potential as immunostimulating compounds and materials for microencapsulation. Their synthesis requires multistep chemical transition from a hydrolytically unstable macromolecular precursor, poly(dichlorophosphazene), to a water-soluble polyelectrolyte. Insufficient synthetic control in these reactions can lead to molecular weight variations and formation of macromolecules with "structural defects" resulting in significant variations in polymer performance. Simple and reproducible "one pot-one solvent" method is reported for the preparation of polyphosphazene polyacids-poly[di(carboxylatophenoxy)phosphazene] and its copolymers. Molecular weight characteristics and polymer compositions were studied as a function of reaction parameters. Macromolecular byproducts, incompletely substituted polymers containing hydroxyl groups and partially deprotected polymers containing propyl ester functionalities, were synthesized and characterized. It was demonstrated, that the presence of such groups can affect polymer characteristics, such as hydrolytic degradation profiles, immunostimulating activity, and microsphere forming properties. In vivo studies showed that the immunostimulating activity of polyphosphazene polyacids correlates with the content of acid functionalities in the polymer.
Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand. (1987)

Tumor necrosis factor (TNF) is a polypeptide produced by monocytes and macrophages. Although TNF receptors have been identified on a variety of cell types, previous studies have not determined whether these receptors also exist on monocytes. In the present work, highly purified recombinant TNF was labeled with 125I. The 125I-labeled TNF bound specifically to receptors on human monocytes and monocyte membrane preparations. A curvilinear Scatchard plot indicated the presence of TNF-binding sites with two different affinities. The results also indicate that receptor-bound TNF is rapidly internalized by monocytes and then degraded intracellularly. These findings are in concert with recent studies demonstrating that TNF immunomodulates monocyte function by an autocrine mechanism.
Immunoglobulin Free Light Chain Dimers in Human Diseases (2011)

Immunoglobulin free light chain (FLC) kappa (κ) and lambda (λ) isotypes exist mainly in monomeric and dimeric forms. Under pathological conditions, the level of FLCs as well as the structure of monomeric and dimeric FLCs and their dimerization properties might be significantly altered. The abnormally high fractions of dimeric FLCs were demonstrated in the serum of patients with multiple myeloma (MM) and primary systemic amyloidosis (AL), as well as in the serum of anephric patients. The presence of tetra- and trimolecular complexes formed due to dimer-dimer and dimer-monomer interactions was detected in the myeloma serum. Analysis of the amyloidogenic light chains demonstrated mutations within the dimer interface, thus raising the possibility that these mutations are responsible for amyloidogenicity. Increased κ monomer and dimer levels, as well as a high κ/λ monomer ratio, were typically found in the cerebrospinal fluid from patients with multiple sclerosis (MS). In many MS cases, the elevation of κ FLCs was accompanied by an abnormally high proportion of λ dimers. This review focuses on the disease-related changes of the structure and level of dimeric FLCs, and raises the questions regarding their formation, function, and role in the pathogenesis and diagnosis of human diseases.
IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts (1992)

IL-12 is a 75-kDa heterodimeric cytokine composed of disulfide-bonded 35-kDa and 40-kDa subunits. Included among the biologic activities mediated by IL-12 is induction of proliferation of PHA-activated human PBL. The concentration of IL-12 required to stimulate maximum proliferation of PHA-activated lymphoblasts is 50 to 100 pM. In this study, highly purified 125I-labeled IL-12 (7 to 15 microCi/microgram; 50 to 100% bioactive) was used to characterize the receptor for IL-12 on 4-day PHA-activated lymphoblasts. The binding of 125I-labeled IL-12 to PHA-activated lymphoblasts was saturable and specific because the binding of radiolabeled ligand was only inhibited by IL-12 and not by other cytokines. The kinetics of [125I]IL-12 binding to PHA-activated lymphoblasts was rapid at both 4 degrees C and 22 degrees C; reaching equilibrium within 60 min. At 22 degrees C, the rate of dissociation of [125I]IL-12 was slow in the absence of competing IL-12 (t1/2 = 5.9 h) and more rapid in the presence of 25 nM competing IL-12 (t1/2 = 2.5 h). The kinetically derived equilibrium dissociation constant ranged from 10 to 83 pM. Analysis of steady state binding data by the method of Scatchard identified a single binding site with an apparent equilibrium dissociation constant of 100 to 600 pM and 1000 to 9000 sites/lymphoblast. The equilibrium dissociation constant for competing ligands and sites per cell calculated from unlabeled IL-12 competition experiments ranged from 164 to 315 pM and 1067 to 3336, respectively, which is in good agreement with the values determined from steady state binding. The variations in KD and sites per cell were dependent on the individual preparations of lymphoblasts. Although the steady state binding data were consistent with a single class of high affinity binding sites, the kinetic dissociation data indicates a cooperative interaction between receptors on PHA-activated lymphoblasts. Affinity cross-linking of surface bound [125I]IL-12 to PHA-activated lymphoblasts at 4 degrees C identified a major complex of approximately 210 to 280 kDa. Anti-IL-12 antibodies also immunoprecipitated a complex of approximately 210 to 280 kDa that was produced by cross-linking unlabeled IL-12 to 125I-labeled lymphoblast cell-surface proteins. Cleavage of this complex with reducing agent identified one radiolabeled protein of approximately 110 kDa. These data suggest that the IL-12 binding site on PHA-activated lymphoblasts may be composed of a single protein of approximately 110 kDa.(ABSTRACT TRUNCATED AT 400 WORDS)
Formation of single crystal sulfur supersaturated silicon based junctions by pulsed laser melting (2007)

The authors demonstrate the formation of pn and nn+ junctions based on silicon supersaturated with sulfur (up to 0.46at.%) using a combination of ion implantation and pulsed laser melting. Silicon wafers were implanted at 200keV S+32 to doses ranging from 1×1015to1×1016ions∕cm2 and subsequently melted and resolidified by using a homogenized excimer laser pulse. Above a threshold laser fluence of ∼1.4J∕cm2, the process produces a single crystal supersaturated alloy, free of extended defects, with a sharp junction between the laser melted layer and the underlying substrate, located near the maximum penetration of the melt front. Hall effect measurements indicate that the laser melted layers are n doped with a free carrier density up to 8×1018∕cm3 that decreases by one-third upon postirradiation furnace annealing at 550°C. Dark current-voltage measurements performed on these structures show good rectifying behavior. The photovoltaic characteristics of the junctions were enhanced by postirradiation annealing at 550–800°C. These effects are attributed to the evolution of a population of point defects that survive the laser treatment. The influence of ion implantation dose, laser fluence, and annealing temperature on the properties of the junctions is also presented and discussed.
The structure and function of SMC proteins (2001)

The newly discovered proteins, SMC (structural maint enance of chromosome) proteins, are associated with chromosome dynamics change i n the cell cycle. They are involved in chromosome condensation, sisterchromati d cohesion, sexchromosome dosage compensation, genetic recombination and DNA r epair,etc. The current understanding of the biochemical properties and biologica l functions of SMC proteins is summarized in this paper.
Urinary oxidative stress markers in children with autism (2011)

The study reveals that the urinary levels of oxidative stress markers can be considered as the measure of oxidative stress index in autistic children. The significant correlation between the severity of autism with urinary lipid peroxidation products also support the use of oxidative stress markers and antioxidants as biomarkers of autism.
Weathering a Cytokine Storm (2016)

Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening disease caused by excessive immune activation. Acquired HLH is seen in adults and is often caused by infection or malignancy. Diagnosis is difficult and usually missed as clinical and laboratory findings are nonspecific. Moreover, the pathophysiology of the systemic inflammatory response syndrome and/or sepsis is remarkably similar to HLH. Thus, in patients presenting with presumed severe sepsis or septic shock complicated by multiorgan failure without a clear infectious source, HLH should be considered. A disproportionately high ferritin may be one of the earlier laboratory findings to suggest HLH. We discuss a case of a young male who presented with presumed septic shock with multiorgan failure who was eventually found to have Epstein-Barr virus-induced HLH.
Autistic Spectrum Disorders in Children (2004)

History, Definition, and Classification of Pervasive Developmental Disorders Vidya B. Gupta The Epidemiology of Autism and Autism Spectrum Disorders Tanya Karapurkar, Nora Lee, Laura Kresch Curran, Craig Newschaffer, and Marshalyn Yeargin-Allsopp Etiology of Autism Vidya B. Gupta Neurological Basis of Autism (Pathophysiology of Autism) Vidya B. Gupta Early Clinical Characteristics of Children with Autism Chris Plauche Johnson Screening and Diagnosis for Autistic Spectrum Disorders Pasquale Accardo Informing, Educating, and Supporting the Family Alfred L. Scherzer Behavioral and Educational Interventions for Young Children with Autism John M. Suozzi Communication Disorders in Children with Autism: Characteristics, Assessment, Treatment Elaine Dolgin Schneider Sensory Integration and Occupational Therapy Intervention for Autistic Spectrum Disorders Pat Stevens, Sallie Tidman, and Kari Glasgow
Oxygen and Temperature Effect on Formation of Degradation Compounds from MEA (2014)

Liquid phase degradation of MEA and the formation of 8 degradation compounds were studied at 4 different oxygen concentrations and three different temperatures. Liquid phase total nitrogen was determined and compared with quantified remaining MEA and degradation compounds. The first order rate constant for MEA degradation was determined and found to increase with both oxygen concentration and temperature. Temperature and oxygen dependence of the degradation compounds were complex. In particular the behaviour at 6% oxygen level was interesting. The end sample liquid phase nitrogen balance is almost closed at 6% O2. The nitrogen accounted for decreases with increasing temperature.
Granulocyte Colony-stimulating Factor Induces egr-1Up-regulation through Interaction of Serum Response Element-binding Proteins (2000)

Granulocyte colony-stimulating factor (G-CSF) stimulates the proliferation and maturation of myeloid progenitor cells both in vitro and in vivo. We showed that G-CSF rapidly and transiently induces expression of egr-1 in the NFS60 myeloid cell line. Transient transfections of NFS60 cells with recombinant constructs containing various deletions of the human egr-1 promoter identified the serum response element (SRE) between nucleotides (nt) -418 and -391 as a critical G-CSF-responsive sequence. The SRE (SRE-1) contains a CArG box, the binding site for the serum response factor (SRF), which is flanked at either side by an ETS protein binding site. We demonstrated that a single copy of the wild-type SRE-1 in the minimal promoter plasmid, pTE2, is sufficient to induce transcriptional activation in response to G-CSF and that both the ETS protein binding site and the CArG box are required for maximal transcriptional activation of the pTE2-SRE-1 construct. In electromobility shift assays using NFS60 nuclear extracts, we identified SRF and the ETS protein Fli-1 as proteins that bind the SRE-1. We also demonstrated through electrophoretic mobility shift assays, using an SRE-1 probe containing a CArG mutation, that Fli-1 binds the SRE-1 independently of SRF. Our data suggest that SRE-binding proteins potentially play a role in G-CSF-induced egr-1 expression in myeloid cells.
The case for controlled inconsistency in replicated data (2002)

Although replication is widely accepted as a good technique for increasing reliability and availability of data, it is also known as an expensive proposition, especially when the number of replicas increases. Protocols that keep the copies consistent, such as two-phase commit, require one or more rounds of messages and have a high overhead in the overall performance. There are some applications that can run perfectly using copies that may not be consistent, as long as the application knows how much the copy can differ from the most recent version of the data. Many of the applications would rather tolerate some inconsistencies of the information in order to provide a better, faster service. A scenario is considered in which the database consists of several segments, each one controlled by a single node (or group of nodes). All the updates to a particular segment of the data take place at its controlling node, while the rest of the system is allowed to ask for quasi-copies of the data contained in the segment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Automatic image capturing and processing for PetrolWatch (2011)

In our previous work [1], we proposed a Participatory Sensing (PS) architecture called PetrolWatch to collect and share fuel prices from camera images of road-side price board (billboard) of service (or gas) stations. A key part of the PetrolWatch architecture, and the main focus of this paper, is the automatic billboard image capture from a moving car without user intervention. We develop the system design and implementation of the automatic image collection for PetrolWatch. Capturing a clear image by an unassisted mobile phone from a moving car is proved to be a challenge by our street driving experiments. We design the camera control and image pre-selection schemes to address this challenge. In particular, we leverage the advanced capabilities of modern mobile phones to design an acceptable camera triggering range and set the camera focus accordingly. Experiment results show that our design improve fuel price extraction rate by more than 40%. To deal with blurred images caused by vehicle vibrations, we design a set of pre-selection thresholds based on the measures from embedded accelerometer of the mobile phone. Our experiments show that our pre-selection improves the system efficiency by eliminating 78.57% of the blurred images.