gebhart/patrepeval huggingface dataset:
Limited Plasmin Proteolysis of Vitronectin (1996)

The adhesion protein vitronectin is associated with extracellular matrices and serves as cofactor for plasminogen-activator inhibitor-1. Limited proteolysis by plasmin converts vitronectin into defined fragments which are detectable at sites of inflammation and angiogenesis. The loss and gain of binding functions of vitronectin fragments for macromolecular ligands was characterized in the present study. The initially generated 61--63-kDa vitronectin-(1--348)-fragment serves as typical binding component for plasminogen and binding function was lost upon carboxypeptidase B treatment indicating the importance of a C-terminal lysine. Complementary binding sites reside in isolated plasminogen kringles 1--3 (designated angiostatin) as deduced from direct binding and ligand blotting experiments. A synthetic vitronectin-(331--348)-peptide from the C-terminus of the 61--63-kDa fragment could mimic plasminogen and angiostatin binding. Also, the immobilized peptide bound tissue plasminogen-activator and mediated plasmin formation, comparable to fibrinogen-derived peptides. The 61--63-kDa vitronectin fragment was indistinguishable in its adhesive properties to intact vitronectin and bound active but not latent plasminogen-activator inhibitor-1. Late plasminolysis of vitronectin resulted in the processing of the N-terminal region of the protein with the generation of 42 kDa/35-kDa fragments that had Gly89 as new N-terminus and that were ineffective in promoting cell adhesion. Thus, at sites of cell-matrix interactions which become proteolytically modified by plasmin during inflammatory and angiogenic processes, vitronectin serves as plasminogen/angiostatin-binding factor. Due to this differential change in functions particularly at sites of deposition in the vascular system or at wound sites vitronectin is considered to be an important morpho-regulatory factor.
Finitely Repeated Games (1985)

Etude systematique des equilibres parfaits de sous jeux pour des jeux repetes de facon finie avec information complete
Gene Expression Profiling of Familial and Sporadic Interstitial Pneumonia (2006)

Taken together, our findings indicate that differences in gene expression profiles between familial and sporadic IIPs may provide clues to the etiology and pathogenesis of IIP.
Specific Recognition of Nucleobase-Functionalized Polythiophenes (1998)

The first nucleobase-functionalized polythiophenes, e.g., the uracil-substituted polythiophene shown in the Figure, produced by electrochemical oxidation of bithiophenes covalently linked to the nucleobases uracil and adenine, are reported. Their synthesis, characterization, and polymerization are detailed and the influence of molecular recognition processes on their electronic properties are described.
Transformation ofStaphylococcus epidermidisand other staphylococcal species with plasmid DNA by electroporation (1990)

In this paper, the influence of various parameters on plasmid tranformation by electroporation of Staphylococcus epidermidis Tü3298 was investigated. Cell growth conditions, various concentrations and forms of plasmid DNA, field strength, pulse duration and media for electroporation and regeneration were tested. In order to obtain optimal transformation efficiency, the cells were incubated for 30 min with DNA before pulsing. With the optimized procedure, other staphylococcal species such as S. aureus, S. staphylolyticus and S. carnosus were transformed with an efficiency up to 3× 105 transformants per μg pC194 plasmid DNA.
Lymphokines and bacteria, that induce tumoricidal activity, trigger a different secretory response in macrophages (1990)

The abilities of various macrophage-activating agents to trigger tumoricidal activity and/or the secretion of prostaglandin E2 (PGE2), interleukin 6 (IL 6) and transforming growth factor beta (TGF beta) in bone marrow-derived mononuclear phagocytes (BMM phi) in vitro were comparatively assessed. Induction of tumoricidal activity by lymphokines, that is only short-lived, was not associated with enhanced secretion of these activities by BMM phi; in contrast, incubation with heat-killed facultative intracellular bacteria resulted in persisting tumoricidal activity and in marked enhancement of the secretion of IL 6 and PGE2, but not of TGF beta activity. These findings support the concept that the pattern of the secretory response induced in macrophages by lymphokines differs from that triggered by bacteria and that the rapid decay of lymphokine-induced tumoricidal activity is not due to autocrine macrophage deactivation mediated by one of these agents alone.
Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus (2008)

The 1918 influenza pandemic was exceptionally severe, resulting in the death of up to 50 million people worldwide. Here, we show which virus genes contributed to the replication and virulence of the 1918 influenza virus. Recombinant viruses, in which genes of the 1918 virus were replaced with genes from a contemporary human H1N1 influenza virus, A/Texas/36/91 (Tx/91), were generated. The exchange of most 1918 influenza virus genes with seasonal influenza H1N1 virus genes did not alter the virulence of the 1918 virus; however, substitution of the hemagglutinin (HA), neuraminidase (NA), or polymerase subunit PB1 genes significantly affected the ability of this virus to cause severe disease in mice. The 1918 virus virulence observed in mice correlated with the ability of 1918 recombinant viruses to replicate efficiently in human airway cells. In a second series of experiments, eight 1918 1:7 recombinants were generated, in which each Tx/91 virus gene was individually replaced by a corresponding gene from 1918 virus. Replication capacity of the individual 1:7 reassortant viruses was assessed in mouse lungs and human airway cells. Increased virus titers were observed among 1:7 viruses containing individual 1918 HA, NA, and PB1 genes. In addition, the 1918 PB1:Tx/91 (1:7) virus showed a distinctly larger plaque size phenotype than the small plaque phenotype of the 1918 PA:Tx/91 and 1918 PB2:Tx/91 1:7 reassortants. These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain.
Proposal of Afipia gen. nov., with Afipia felis sp. nov. (formerly the cat scratch disease bacillus), Afipia clevelandensis sp. nov. (formerly the Cleveland Clinic Foundation strain), Afipia broomeae sp. nov., and three unnamed genospecies (1991)

On the basis of phenotypic characterization and DNA relatedness determinations, the genus Afipia gen. nov., which contains six species, is described. The type species is Afipia felis sp. nov. (the cat scratch disease bacillus). Afipia clevelandensis sp. nov., Afipia broomeae sp. nov., and three unnamed not associated with cat-borne disease. All but one strain (Afipia genospecies 3) were isolated from human wound and respiratory sources. All Afipia species are gram-negative, oxidase-positive, nonfermentative rods in the alpha-2 subgroup of the class Proteobacteria. They are motile by means of a single flagellum. They grow on buffered charcoal-yeast extract agar and nutrient broth, but rarely on MacConkey agar, at 25 and 30 degrees C. They are urease positive; but they are negative in reactions for hemolysis, indole production, H2S production (triple sugar iron agar), gelatin hydrolysis, esculin hydrolysis, and peptonization of litmus milk. They do not produce acid oxidatively from D-glucose, lactose, maltose, or sucrose. The major cell wall fatty acids are 11-methyloctadec-12-enoic (CBr19:1), cis-octadec-11-enoic (C18:1omega7c), and generally, 9,10-methylenehexadecanote and 11,12-methyleneoctadecanoate; and there are only trace amounts of hydroxy acids. The guanineplus-cytosine content is 61.5 to 69 mol%. A. felis is positive for nitrate reduction and is delayed positive for acid production from D-xylose, but it is catalase negative. A. clevelandensis is negative in all of these tests. A. broomeae is weakly positive for catalase production and acid production from D-xylose, but it is negative for nitrate reduction.
Treatment of Relapsed or Refractory Chronic Lymphocytic Leukemia (2012)

Despite improvement in initial overall response rates, most patients relapse and require further treatment. CLL remains incurable with standard therapies due to development of disease refractoriness. As such, novel approaches such as those noted above warrant continued research to improve outcomes for patients with CLL.
Sensorless Drives in Industrial Applications (2011)

The changes in the market of motor drives over the last few years, especially the wish to complete the portfolio toward the satisfaction of most of the customer needs, have brought a new thrust in the area of drives and have favored the realization of procedures that were known from academic discussion. Under certain conditions, the injection sensorless control schemes that exploit the anisotropy of the AC machine and inject a test signal are now found in drives with permanent magnet synchronous machine, while the fundamental wave procedures seem to be the most common solution in the case of induction machines. In this paper, different aspects regarding the state of the art of sensorless drives in industrial applications and the reasons that determine the acceptance or refusal of the different solutions on the side of manufacturers of motor drives are explained and discussed.
Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels (2010)

The lung contains large numbers of EPCs that display commitment for both types of vessels, suggesting that lung blood and lymphatic endothelial cells are derived from a single progenitor cell.
CCR2 Expression Determines T1 Versus T2 Polarization During Pulmonary Cryptococcus neoformans Infection (2000)

Pulmonary clearance of the encapsulated yeast Cryptococcus neoformans requires the development of T1-type immunity. The objective of this study was to determine the role of CCR2 in leukocyte recruitment and development of T1-type cell-mediated immunity during pulmonary C. neoformans infection. Intratracheal inoculation of C. neoformans into CCR2 knockout (CCR2-/-) mice produced a prolonged pulmonary infection (5000-fold CFU at 6 wk compared with CCR2+/+ mice) and significant dissemination to the spleen and brain (160- and 800-fold greater). In addition, CCR2 deficiency resulted in significantly reduced recruitment of macrophages (weeks 1-3) and CD8+ T cells (weeks 1-2) into the lungs. The immune response in CCR2-/- mice was characterized by chronic pulmonary eosinophilia, crystal deposition in the lungs, pulmonary leukocyte production of IL-4 and IL-5 but not IFN-gamma, lack of anticryptococcal delayed-type hypersensitivity, and high levels of serum IgE. These results demonstrate that expression of CCR2 is required for the development of a T1-type response to C. neoformans infection and lack of CCR2 results in a switch to a T2-type response. Thus, CCR2 plays a critical role in promoting the development of T1- over T2-type immune responses in the lung following cryptococcus infection.
Interaction techniques for using handhelds and PCs together in a clinical setting (2006)

In the present study we compare interaction techniques for using handheld devices together with stationary displays in a hospital setting. A set of prototype implementations were developed and tested for a pre-surgery scenario with pairs of physicians and patients. The participants were asked to rank the interaction techniques in order of preference. The results show highest ranking for a distributed user interface where the GUI elements reside on the handheld and where the stationary display is used for showing media content. An analysis of the factors affecting the usability shows that in addition to GUI usability, the interaction techniques were ranked based on ergonomic and social factors specific to the use situation. The latter include the physicality of the patient bed and how computing devices potentially interrupt the face-to-face communication between physician and patient. The study illustrates how the usability of interaction techniques for ubiquitous computing is affected by the ergonomic and social factors of each specific use context.
Study of serum C-reactive protein concentration in cardiac failure. (1990)

The serum concentration of C-reactive protein was prospectively assessed in 37 patients with various degrees of heart failure. The serum concentration of C-reactive protein was higher than normal in 26 (70%) patients. The concentration was directly related to the severity of heart failure and the stage of decompensation. Hepatic cell damage is the most likely stimulus to cytokine production and hence release of C-reactive protein in heart failure. Heart failure is an additional cause of raised serum concentration of C-reactive protein but the pathological importance of this feature is not yet known.
Ectopic atrial natriuretic peptide production in small cell lung cancer with the syndrome of inappropriate antidiuretic hormone secretion (1991)

One autopsy case with small cell lung cancer and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is reported. Both plasma atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) levels were high, and the presence of significantly high levels of ANP and AVP in tumor tissue was confirmed by gel chromatography and radioimmunoassay techniques. To the best of the authors' knowledge, this is the first case in which ectopic ANP production and its secretion into blood (leading to SIADH) were proved.
Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats. (1991)

The centromere-associated B' and B DNA sequence repeats of Schizosaccharomyces pombe chromosomes I and II have been found to contain clusters of tRNA genes. The centromere II region (cen2) includes at least 22 tRNA genes distributed among five copies of the B sequence repeat containing genes specifying tRNA(Ile), tRNA(Ala), and tRNA(Val). Individual B repeats are variously associated with other tRNA genes, including those specifying tRNA(Lys), tRNA(Arg), and tRNA(Glu2). The centromere I region (cen1) contains at least six tRNA genes in two copies of the B' repeated element, including genes specifying tRNA(Ile), tRNA(Ala), and tRNA(Glu3). Multiple tandemly arranged clusters of tRNA genes are presumably conserved due to restricted recombination frequencies in the centromere regions.
Classical and Modern Direction-of-Arrival Estimation (2009)

Brings together in one book classical and modern DOA techniques, showing the connections between themContains contributions from the leading people in the fieldGives a concise and easy- to- read introduction to the classical techniquesEvaluates the strengths and weaknesses of key super-resolution techniquesIncludes applications to sensor networksClassical and Modern Direction of Arrival Estimation contains both theory and practice of direction finding by the leading researchers in the field. This unique blend of techniques used in commercial DF systems and state-of-the art super-resolution methods is a valuable source of information for both practicing engineers and researchers. Key topics covered are: Classical methods of direction findingPractical DF methods used in commercial systemsCalibration in antenna arraysArray mapping, fast algorithms and wideband processingSpatial time-frequency distributions for DOA estimationDOA estimation in threshold regionHigher order statistics for DOA estimationLocalization in sensor networks and direct position estimationT. Engin Tuncer is a Professor in Electrical and Electronics Engineering Department of Middle East Technical University, Turkey. His research is focused on sensor array and multichannel signal processing, statistical signal processing and communications.Ben Friedlander is an internationally known expert in the areas of statistical signal processing and its applications to communications and surveillance systems. He has extensive experience spanning over three decades in array processing and direction finding. In recent years his work focused on the use of multiple antennas for wireless communications. Currently he is a professor of electrical engineering at the University of California at Santa Cruz. Brings together in one book classical and modern DOA techniques, showing the connections between themContains contributions from the leading people in the fieldGives a concise and easy- to- read introduction to the classical techniquesEvaluates the strengths and weaknesses of key super-resolution techniquesIncludes applications to sensor networks
A Comparison and Scenario Analysis of Leading Data Mining Software (2008)

Finding the right software is often hindered by different criteria as well as by technology changes. We performed an analytic hierarchy process (AHP) analysis using Expert Choice to determine which data mining package was best suitable for us. Deliberating a dozen alternatives and objectives led us to a series of pair-wise comparisons. When further synthesizing the results, Expert Choice helped us provide a clear rationale for the decision. The issue is that data mining technology is changing very rapidly. Our article focused only on the major suppliers typically available in the market place. The method and the process that we have used can be easily applied to analyze and compare other data mining software or knowledge management initiatives.
Epitope Analysis of the Envelope and Non-structural Glycoproteins of Murray Valley Encephalitis Virus (1990)

Previous studies have shown that antibodies produced against strategic flavivirus epitopes play an important role in recovery and immunity. Definition of the conformation and location of these epitopes and the degree of their conservation among flaviviruses is important to understanding the humoral response to flavivirus infection. In this study we have examined epitopes recognized by 14 monoclonal antibodies (MAbs) produced to the envelope (E) and non-structural (NS1) proteins of Murray Valley encephalitis virus (MVE). These antibodies were analysed for specificity, neutralization, haemagglutination inhibition (HI) and competitive binding. We have identified six distinct epitopes on the E protein which are located in four non-overlapping domains. MAbs to epitopes in one domain neutralized virus, were specific for MVE and Japanese encephalitis virus, and reacted with epitopes resistant to reduction. Two other E domains, one specific to MVE and the other shared by all flaviviruses, also contained neutralization sites and were stabilized by disulphide bonds. The fourth domain on E was conserved among the flaviviruses, sensitive to SDS denaturation and did not induce neutralizing antibody. Studies with MVE NS1 MAbs revealed that they were mostly type-specific, unreactive with conserved epitopes, and unreactive in HI and neutralization tests. The six epitopes identified on NS1 did not overlap and represent antigenic domains either resistant or sensitive to reduction. Immunoblotting of viral proteins in MVE-infected C6/36 cells revealed two distinct forms of NS1 and high Mr proteins of 97K and 108K that represented disulphide-linked heterodimers of E and NS1.
Applying Telemedicine to Outpatient Physical Therapy. (2002)

Few studies have specifically addressed telemedicine applied to physical rehabilitation. This ongoing pilot study examines the role of Internet-based, World Wide Web electronic communication, including textual, audio, and video, over a HIPAA-compliant network configuration, to enhance patient care in an outpatient physical therapy rehabilitation setting. Areas that can benefit from telemedicine are targeted, and include communication between physical therapist and specialty therapist, between physical therapist and treating physician, between physical therapist and case manager and insurance adjustor, and between physical therapist and their patients. Evaluation will examine potential cost savings and improved patient care when telemedicine is applied to rehabilitation.
Effect of salcatonin given intranasally on bone mass and fracture rates in established osteoporosis: a dose-response study. (1992)

The results suggest that, compared with calcium alone, salcatonin given intranasally reduces the rates of fracture by two thirds in elderly women with moderate osteoporosis. Furthermore, it increases spinal bone mass in a dose dependent manner.
Why cells respond differently to DNA damage: A chromatin perspective (2008)

In response to DNA double-stranded breaks (DSBs) cells activate a signaling cascade known as the DNA damage response (DDR) whose main function is to promote the repair of the lesions while it delays cell cycle progression until repair is completed. Whereas most cells respond alike to an equivalent dose of DNA damage, certain degree of heterogeneity exists in the strength of the DDR that is assembled in each individual cell. This variability might be accounted for by erratic changes that aggregate into the inherent noise of biological systems. However, we have recently found that the overall degree of chromatin compaction impinges a direct constrain on the activation of the DDR, providing a simple chromatin-based model to explain the cell-to-cell variability observed in cell populations. We here provide an overview of the available data, including our own, that would be supportive of such a model and discuss how this perspective might be used to explain previous observations.
Crown Ethers:  Sensors for Ions and Molecular Scaffolds for Materials and Biological Models (2004)

ADVERTISEMENT RETURN TO ISSUEPREVarticleNEXTCrown Ethers: Sensors for Ions and Molecular Scaffolds for Materials and Biological ModelsGeorge W. Gokel*George W. GokelDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 To whom correspondence should be addressed. Phone: 314-362-9297. Fax: 314-362-9298. E-mail: [email protected].More by George W. Gokel, W. Matthew LeevyW. Matthew LeevyDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 More by W. Matthew Leevy, and Michelle E. WeberMichelle E. WeberDepartments of Molecular Biology & Pharmacology and Chemistry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110 More by Michelle E. WeberCite this: Chem. Rev. 2004, 104, 5, 2723–2750Publication Date (Web):March 19, 2004Publication History Published online19 March 2004Published inissue 1 May 2004https://pubs.acs.org/doi/10.1021/cr020080khttps://doi.org/10.1021/cr020080kresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views18799Altmetric-Citations1282LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cations,Complexation,Ethers,Ions,Macrocyclic compounds Get e-Alerts
Thiocarbonic Acids and Derivatives (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.