gebhart/patrepeval huggingface dataset:
Spin on dopants for high-performance single-crystal silicon transistors on flexible plastic substrates (2005)

Free-standing micro/nanoelements of single-crystal silicon with integrated doped regions for contacts provide a type of material that can be printed onto low-temperature device substrates, such as plastic, for high-performance mechanically flexible thin-film transistors (TFTs). We present simple approaches for fabricating collections of these elements, which we refer to as microstructured silicon (μs-Si), and for using spin-on dopants to introduce doped regions in them. Electrical and mechanical measurements of TFTs formed on plastic substrates with this doped μs-Si indicate excellent performance. These and other characteristics make the material potentially useful for emerging large area, flexible ‘macroelectronic’ devices.
GA-based approaches for finding the minimum reference set for nearest neighbor classification (2002)

In this paper, we examine the ability of genetic algorithms to find a compact reference set for nearest neighbor classification. The task of genetic algorithms is to select a small number of reference patterns from a large number of given training patterns. Our pattern selection problem has two objectives: to maximize the classification performance of the reference set and to minimize the size of the reference set. In our genetic algorithm, they are combined into a single scalar fitness function using a constant weight for each objective. Thus our pattern selection problem is handled as a single-objective combinatorial optimization problem with 0-1 variables where "1" means the inclusion of the corresponding pattern in the reference set and "0" means the exclusion. In this paper, we first briefly explain our genetic algorithm for the pattern selection problem for nearest neighbor classification. Next we examine the ability of the genetic algorithm to find a compact reference set by computer simulations on commonly used real-world pattern classification problems. Finally, we suggest some extensions of our genetic algorithm.
Spectral Regression based age determination (2010)

In this paper, we introduce an advanced age determination technique that combines a feature set derived from an image of the face using multi-factored Principal Components Analysis (PCA) on the shape of the face and its features and the skin of the face to produce a 30 × 1 linear encoding of the face. The linearly encoded features are combined with Spectral Regression (SR) to improve performance of age determination over the current best techniques. The technique of SR is used to further reduce the dimensionality of the face encoding such that inter-class distances are minimized while maximizing intra-class distances. The SR feature vector is used to classify a face into one-of-two age groups (age recognition). An age-determination function is constructed for each age group in accordance to physiological growth periods for humans - pre-adult (youth) and adult. Compared to published results, this method yields the highest accuracy rates in overall mean-absolute error (MAE), mean-absolute error per decade of life (MAE/D), and cumulative match score.
Global Operations and Logistics Trends in the Household and Personal Care Products Market (2003)

The household and personal care products market is $120 billion worldwide. Unilever and Procter and Gamble have half of the world market for this segment of consumer products industry. Major markets include skin care and cosmetics. Both of the markets are increasing as the baby boomer generation sees the need for adequate skin care to fight wrinkles and sun damaged skin. Technology is playing a large role in this industry in how companies move their products. Changes in marketplace, specifically impact of Wall-Mart, are pushing suppliers to rethink their customer relationships, by way of service differentiation, and extended supply chains. The analysis also describes: performance measurement; logistics trends; key market players; the products that make up this industry; and how these products are moved through the stages in the current and possible future supply chains. A SWOT analysis enables recognition of significant factors influencing the performance of this industry.
Cardiomyogenesis is controlled by the miR-99a/let-7c cluster and epigenetic modifications (2013)

Understanding the molecular basis of cardiomyocyte development is critical for understanding the pathogenesis of pre- and post-natal cardiac disease. MicroRNAs (miRNAs) are post-transcriptional modulators of gene expression that play an important role in many developmental processes. Here, we show that the miR-99a/let-7c cluster, mapping on human chromosome 21, is involved in the control of cardiomyogenesis by altering epigenetic factors. By perturbing miRNA expression in mouse embryonic stem cells, we find that let-7c promotes cardiomyogenesis by upregulating genes involved in mesoderm specification (T/Bra and Nodal) and cardiac differentiation (Mesp1, Nkx2.5 and Tbx5). The action of let-7c is restricted to the early phase of mesoderm formation at the expense of endoderm and its late activation redirects cells toward other mesodermal derivatives. The Polycomb complex group protein Ezh2 is a direct target of let-7c, which promotes cardiac differentiation by modifying the H3K27me3 marks from the promoters of crucial cardiac transcription factors (Nkx2.5, Mef2c, Tbx5). In contrast, miR-99a represses cardiac differentiation via the nucleosome-remodeling factor Smarca5, attenuating the Nodal/Smad2 signaling. We demonstrated that the identified targets are underexpressed in human Down syndrome fetal heart specimens. By perturbing the expression levels of these miRNAs in embryonic stem cells, we were able to demonstrate that these miRNAs control lineage- and stage-specific transcription factors, working in concert with chromatin modifiers to direct cardiomyogenesis.
Antineoplastic Urinary Protein Inhibits Kaposi’s Sarcoma and Angiogenesis In Vitro and In Vivo (1999)

Kaposi’s sarcoma (KS) is the most common tumor in human immunodeficiency virus infection and acquired immune deficiency syndrome. Recent clinical trials with human chorionic gonadotropin (hCG) prepared from early pregnancy urine have shown encouraging results in the resolution of KS lesions. A urinary protein with antitumor activity, ANUP (antineoplastic urinary protein), a dimer of 32 kD, has previously been shown to inhibit the growth of various tumor cell lines in vivo. It was thus studied for its activity in KS cell lines in vitro and in vivo to determine whether it could be a source of the anti-KS activity observed in hCG preparations. ANUP is a strong growth inhibitor for KS cell lines, but has little or no effect on fibroblast, aortic smooth muscle, T- and B-lymphocyte, and monocyte cell lines. ANUP also inhibited the proliferation of endothelial cell lines, suggesting that the in vitro effects were endothelial cell lineage–specific. However, ANUP antibodies did not block the inhibitory effect of certain commercial preparations of hCG, previously shown to be active in KS. Thus, the active protein in these commercial preparations of hCG may be distinct from ANUP. The antitumor activity of ANUP was further confirmed in a chicken allantoic membrane (CAM) assay in which vascular endothelial growth factor (VEGF) and beta fibroblast growth factor (bFGF)-induced angiogenesis was inhibited by ANUP in a dose-dependent manner. In vivo activity of ANUP was demonstrated in the murine model of KS, where ANUP inhibited tumor growth. ANUP is thus a potential candidate for development in the treatment of KS and other diseases in which angiogenesis plays an important role.
Orthotic Considerations and Footwear Modifications Following Ankle Fusions (2002)

This manuscript serves to educate the reader as to pedorthic and orthotic principles and tools available to the surgeon when managing those with ankle fusions. Footwear, footwear modifications, foot orthoses, and ankle foot orthoses with be illustrated as necessary postoperative recommendations after primary ankle arthrodeses or in light of secondary complications. The document also serves to inform the reader of biomechanical objectives, including replacing lost motion, protection of associated articulations, and the accommodation for any leg length discrepancies created from the surgery. Footwear and footwear modifications should be very closely evaluated and discussed when managing patients with ankle fusions to insure higher quality outcomes. Foot orthoses and ankle foot orthoses may be necessary if dealing with a nonunion or a malalignment case. This paper will explore these options when and if faced with secondary complications from this type of surgery.
Expression of Vascular Endothelial Growth Factor Receptor-3 by Lymphatic Endothelial Cells Is Associated with Lymph Node Metastasis in Prostate Cancer (2004)

Together, these results suggest that paracrine activation of lymphatic endothelial cell VEGF receptor-3 by VEGF-C and/or VEGF-D may be involved in lymphatic metastasis. Thus the VEGF-C/VEGF-D/VEGF receptor-3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer.
ChemInform Abstract: Synthesis of 2,5‐Disubstituted 3‐(Phenylsulfonyl)pyrrolidines via 5‐endo‐Trig Cyclization Reactions. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthetic aperture superresolution with multiple off-axis holograms (2006)

An optical setup to achieve superresolution in microscopy using holographic recording is presented. The technique is based on off-axis illumination of the object and a simple optical image processing stage after the imaging system for the interferometric recording process. The superresolution effect can be obtained either in one step by combining a spatial multiplexing process and an incoherent addition of different holograms or it can be implemented sequentially. Each hologram holds the information of each different frequency bandpass of the object spectrum. We have optically implemented the approach for a low-numerical-aperture commercial microscope objective. The system is simple and robust because the holographic interferometric recording setup is done after the imaging lens.
Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong (2010)

The genetic basis of chronic lymphocytic leukemia (CLL) has not been fully elucidated to date. Although it is the most common haematological malignancy in Caucasians, it is uncommon among Asians. A recent genome-wide scan of CLL in Caucasians, which was carried out in the UK, identified six variants showing strong association. We attempted to replicate these findings in 71 patients with CLL and 1273 controls in Hong Kong Chinese. Three of the six variants were significantly associated with CLL. The rs872071 variant (Odds Ratio (95% Confidence Interval) = 1.78 (1.25-2.53), P = 0.0013) in the IRF4 gene region showed the strongest association, similar to that reported in the UK study. Polymorphisms in SP140 and ACOXL were also associated with risk of CLL. Further, the mean allele frequencies of the six variants were moderately (59%) to extremely (0.5%) lower in the Chinese population compared with Caucasians. These results suggest that variants in three loci may contribute to risk of CLL among Chinese.
Motion-Sensorless Control of BLDC-PM Motor With Offline FEM-Information-Assisted Position and Speed Observer (2012)

This paper proposes and investigates an offline finite-element-method (FEM)-assisted position and speed observer for brushless dc permanent-magnet (PM) (BLDC-PM) motor drive sensorless control based on the line-to-line PM flux linkage estimation. The zero crossing of the line-to-line PM flux linkage occurs right in the middle of two commutation points (CPs) and is used as a basis for the position and speed observer. The position between CPs is obtained by comparing the estimated line-to-line PM flux with the FEM-calculated line-to-line PM flux. Even if the proposed observer relies on the fundamental model of the machine, a safe starting strategy under heavy load torque, called <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> control, is used, with seamless transition to the proposed sensorless control. The <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</i> - <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</i> starting method allows low-speed sensorless control, without knowing the initial position and without machine parameter identification. Digital simulations and experimental results are shown, demonstrating the reliability of the FEM-assisted position and speed observer for BLDC-PM motor sensorless control operation.
Bacteriophage lambda vector for transducing a cDNA clone library into mammalian cells. (1985)

We have developed a bacteriophage lambda vector (lambda NMT) that permits efficient transduction of mammalian cells with a cDNA clone library constructed with the pcD expression vector (H. Okayama and P. Berg, Mol. Cell. Biol. 3:280-289, 1983). The phage vector contains a bacterial gene (neo) fused to the simian virus 40 early-region promoter and RNA processing signals, providing a dominant-acting selectable marker for mammalian transformation. The phage DNA can accommodate pcD-cDNA recombinants with cDNA of up to about 9 kilobases without impairing the ability of the phage DNA to be packaged in vitro and propagated in vivo. Transfecting cells with the lambda NMT-pcD-cDNA recombinant phage yielded G418-resistant clones at high frequency (approximately 10(-2]. Cells that also acquired a particular cDNA segment could be detected among the G418-resistant transformants by a second selection or by a variety of screening protocols. Reconstitution experiments indicated that the vector could transduce 1 in 10(6) cells for a particular phenotype if the corresponding cDNA was present as 1 functional cDNA clone per 10(5) clones in the cDNA library. This expectation was confirmed by obtaining two hypoxanthine-guanine phosphoribosyltransferase (HPRT)-positive transductants after transfecting 10(7) HPRT-deficient mouse L cells with a simian virus 40-transformed human fibroblast cDNA library incorporated into the lambda NMT phage vector. These transductants contained the human HPRT cDNA sequences and expressed active human HPRT.
Tumor Growth Control Using Red Blood Cells as the Antigen Delivery System and Poly(I (2012)

The goal of most current vaccines in tumor immunology is to induce an efficient immune response against the tumor cells. The use of red blood cells (RBCs) for the delivery of tumor-associated antigen to antigen-presenting cells is an innovative approach for cancer immunotherapy. The induction of antigen-specific immune responses after administration of antigen-loaded RBCs has been demonstrated previously in mice. In this paper, we show the utility of this delivery system for cancer immunotherapy in 2 tumor mouse models, using the E.G7-OVA and the B16F10 tumor cells. The non-self-antigen, ovalbumin, loaded in RBCs and the self-tumor antigen, tyrosinase-related protein 2, loaded in RBCs were tested in the E.G7-OVA and the B16F10 tumor models, respectively. We showed that not only protein but also peptide could be efficiently entrapped in RBCs by a controlled lysis/resealing process. In both antigen models, the administration of a small quantity of antigen loaded in RBCs combined with polyinosinic-polycytidylic acid induced an antigen-specific T-cell response and the control of tumor growth in mice, whereas the injection of the same quantity of free antigen did not. The intensity of the T-cell response was dependent on the concentrations of antigen entrapped and the treatment performed on the RBC membrane (antibody coating and heat treatment) to improve antigen delivery. In summary, these results support the use of RBCs as an antigen delivery system for a powerful cancer immunotherapy approach.
Metalation and Halogen-Metal Interconversion Reactions of Some Halogenated Phenyl Ethers (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetalation and Halogen-Metal Interconversion Reactions of Some Halogenated Phenyl EthersWright Langham, R. Q. Brewster, and Henry GilmanCite this: J. Am. Chem. Soc. 1941, 63, 2, 545–549Publication Date (Print):February 1, 1941Publication History Published online1 May 2002Published inissue 1 February 1941https://pubs.acs.org/doi/10.1021/ja01847a053https://doi.org/10.1021/ja01847a053research-articleACS PublicationsRequest reuse permissionsArticle Views289Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Macrophage Migration Inhibitory Factor (MIF) (2003)

Macrophage migration inhibitory factor (MIF) functions as a pluripotent cytokine involved in broad-spectrum pathophysiological events in association with inflammation and immune responses. Several reports, including ours, have suggested that MIF is also involved in tumorigenesis; however, its precise role has not been fully investigated. We examined the effectiveness of anti-MIF antibodies on tumor growth and tumor-associated angiogenesis using murine colon cancer cell line, colon 26. We observed a significant inhibition of growth of tumors embedded on the back of BALB/c mice by treatment with anti-MIF antibodies. Next, we implanted a Millipore chamber filled with colon cancer cells in the subcutaneous fascia of the flanks of mice and then treated them with anti-MIF antibodies. We found that angiogenesis was markedly suppressed within the region of the subcutaneous fascia that was in contact with the chamber. To further assess the role of MIF in tumorigenesis, we established MIF transgenic mice, which demonstrated that tumor growth and the associated angiogenesis were significantly enhanced in comparison with control mice.
The principal neutralizing determinant of HIV‐1 located in V3 of gp120 forms a 12‐residue loop by internal hydrophobic interactions (1995)

The interactions of the peptide RP135a (RKSIRIQRGPGRAFVT), corresponding to residues 311–326 of gp120 of HIV‐1 IIIB , with the anti‐gp120 HIV‐1 IIIB neutralizing antibody 0.5β were studied by NMR. The NOESY difference spectra measured using specifically deuterated derivatives of the peptide show exclusively the interactions of the deuterated residues both within the bound peptide and with the Fab fragment of the antibody. These measurements reveal hydrophobic interactions within the bound peptide between Ile‐4, Ile‐6 and Val‐15 that create a 12‐residue loop with these residues at the base and the conserved GPGR sequence at its top.
Sequencing, distribution, and inactivation of the dipeptidase A gene (pepDA) from Lactobacillus helveticus CNRZ32 (1996)

Previously, the gene for a general dipeptidase (pepDA) was isolated from a gene bank of Lactobacillus helveticus CNRZ32. The pepDA gene consists of a 1,422-bp open reading frame which could encode a polypeptide of 53.5 kDa. No significant identity was found between the deduced amino acid sequence of the pepDA product and the sequence for other polypeptides reported in GenBank. Southern hybridization studies with a pepDA probe indicated that the nucleotide sequence for pepDA is not well conserved among a variety of lactic acid bacteria. Growth studies indicated that a pepDA deletion had no detectable effect on growth rate or acid production by L. helveticus CNRZ32 in milk. Furthermore, no difference in total cellular dipeptidase activity was detected between the mutant and wild-type strains during logarithmic growth in MRS medium.
Antithrombotic actions of argatroban in rat models of venous, ‘mixed’ and arterial thrombosis, and its effects on the tail transection bleeding time (1994)

1. The antithrombotic action of argatroban, a synthetic thrombin inhibitor, was studied in three models of thrombosis in the rat, and in the tail transection bleeding time test. Heparin was studied as a reference anticoagulant. 2. In the model of venous thrombosis induced by thromboplastin followed by stasis of the abdominal vena cava, argatroban had an ED50 of 125 micrograms kg-1, when administered as an i.v. bolus 5 min prior to the thromboplastin injection: the ED50 of heparin was 42 micrograms kg-1, where ED50 is the dose which reduces the weight of the thrombus by 50% compared with that of the control animals. When the two compounds were administered by continuous i.v. infusion, argatroban (ED50 = 1.5 micrograms kg-1 min-1) had the same potency as heparin (ED50 = 1.2 micrograms kg-1 min-1). 3. Argatroban was active in the arterio-venous shunt model with an ED50 of 0.6 mg kg-1 when the compound was given as a bolus. The ED50 of heparin was 0.04 mg kg-1 under the same conditions. The two compounds had ED50 values of 6 micrograms kg-1 min-1 (argatroban) and 3 micrograms kg-1 min-1 (heparin), when administered by continuous i.v. infusion. 4. When tested against occlusive arterial thrombus formation by electrical stimulation of the left carotid artery, both compounds given as either an i.v. bolus or a continuous infusion led to dose-dependent increases in the duration of post-lesion vessel patency. Heparin bolus was more active than argatroban on a weight basis, in that 2 mg kg-1 gave a similar increase in the time to occlusion as 8 mg kg-1 argatroban. As in the other models, when given as continuous infusions, argatroban (111% increase in time to occlusion at 20 tg kg-1, min-1) had similar activity to that of heparin (180% increase at 25 jg kg-1 min-1) on a weight basis. Hoever, the antithrombotic effects of argatroban were accompanied by only moderate changes in the coagulation parameters (thrombin time and activated partial thromboplastin time, APTT), whereas, even at a subthreshold dose of heparin (12.5 pg kg-1 min-1), both the thrombin time and the APTT were greater than 150 s.5. Infusions of both compounds caused dose-dependent increases in the tail transection bleeding time,with the dose of argatroban that doubles the bleeding time (11 I g kg-1 min-1) being five times greater than that of heparin (EDI, = 2.2 fig kg-1 min-1).6. These data show that, when administered as an intravenous infusion, argatroban is a potent antithrombotic agent in rat models of venous 'mixed' and arterial thrombosis, this effect can be obtained with a lower degree of systemic anticoagulation than with heparin in the arterial model, and argatroban has a lower haemorrhagic potential than that of heparin.