gebhart/patrepeval huggingface dataset:
Virtual reality on a WIM (1995)

Article Free Access Share on Virtual reality on a WIM: interactive worlds in miniature Authors: Richard Stoakley The University of Virginia, Department of Computer Science, Charlottesville, VA The University of Virginia, Department of Computer Science, Charlottesville, VAView Profile , Matthew J. Conway The University of Virginia, Department of Computer Science, Charlottesville, VA The University of Virginia, Department of Computer Science, Charlottesville, VAView Profile , Randy Pausch The University of Virginia, Department of Computer Science, Charlottesville, VA The University of Virginia, Department of Computer Science, Charlottesville, VAView Profile Authors Info & Claims CHI '95: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsMay 1995 Pages 265–272https://doi.org/10.1145/223904.223938Published:01 May 1995Publication History 516citation5,098DownloadsMetricsTotal Citations516Total Downloads5,098Last 12 Months669Last 6 weeks88 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling (2005)

The vasculature of the embryo requires vascular endothelial growth factor (VEGF) during development, but most adult blood vessels lose VEGF dependence. However, some capillaries in the respiratory tract and selected other organs of adult mice regress after VEGF inhibition. The present study sought to identify the sequence of events and the fate of endothelial cells, pericytes, and vascular basement membrane during capillary regression in mouse tracheas after VEGF signaling was blocked with a VEGF-receptor tyrosine kinase inhibitor AG-013736 or soluble receptor construct (VEGF Trap or soluble adenoviral VEGFR-1). Within 1 day, patency was lost and fibrin accumulated in some tracheal capillaries. Apoptotic endothelial cells marked by activated caspase-3 were present in capillaries without blood flow. VEGF inhibition was accompanied by a 19% decrease in tracheal capillaries over 7 days and 30% over 21 days. During this period, desmin/NG2-immunoreactive pericytes moved away from regressing capillaries onto surviving vessels. Empty sleeves of basement membrane, left behind by regressing endothelial cells, persisted for about 2 wk and served as a scaffold for vascular regrowth after treatment ended. The amount of regrowth was limited by the number of surviving basement membrane sleeves. These findings demonstrate that, after inhibition of VEGF signaling, some normal capillaries regress in a systematic sequence of events initiated by a cessation of blood flow and followed by apoptosis of endothelial cells, migration of pericytes away from regressing vessels, and formation of empty basement membrane sleeves that can facilitate capillary regrowth.
Learning Correspondence from the Cycle-Consistency of Time (2019)

We introduce a self-supervised method for learning visual correspondence from unlabeled video. The main idea is to use cycle-consistency in time as free supervisory signal for learning visual representations from scratch. At training time, our model learns a feature map representation to be useful for performing cycle-consistent tracking. At test time, we use the acquired representation to find nearest neighbors across space and time. We demonstrate the generalizability of the representation -- without finetuning -- across a range of visual correspondence tasks, including video object segmentation, keypoint tracking, and optical flow. Our approach outperforms previous self-supervised methods and performs competitively with strongly supervised methods.
The relationship between worry, sexual aversion, and low sexual desire (1999)

The psychological trait of worry is associated with many psychiatric conditions and maladaptive ways of coping, but is relationship to sexual dysfunctions, and desire disorders in particular, is unclear. In this study, we assessed the relationship between worry, sexual aversion, and low sexual desire using the Sexual Aversion Scale, the Hurlbert Index of Low Sexual Desire, and the Penn State Worry Questionnaire. Data were collected from 138 college undergraduates. As expected, results showed a modest but significant relationship between sexual aversion and low sexual desire, which is consistent with the taxonomy of the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; American Psychiatric Association, 1994), which lists sexual aversion disorder and hypoactive sexual desire disorder as separate but related conditions. Contrary to our prediction, however, the tendency to worry was no more related to sexual aversion than it was to low sexual desire. The relationship between these variables was significant, but it was also relatively weak. We conclude that chronic and intense worry may predispose one to certain anxiety disorders, but it does not appear to be a risk factor for sexual desire problems in nonclinical populations.
Factors influencing myofibroblast differentiation during wound healing and fibrosis. (1995)

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilaments bundles and the expression of alpha-SM actin, the actin isoform typical of contractile vascular SM cells. Myofibroblasts have been suggested to play a role in wound contraction and in retractile phenomena observed during fibrotic diseases. When granulation tissue evolves into a scar, myofibroblasts containing alpha-SM actin disappear, probably as a result of apoptosis. In contrast myofibroblasts expressing alpha-Sm actin persist in excessive scarring and in fibrotic conditions. The mechanisms leading to the development of myofibroblastic features remain to be investigated. Studies on the factors regulating the phenotype of myofibroblasts will be necessary for understanding their behavior in vivo, and possibly modifying this behavior during the different clinical settings.
Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3 (2008)

The selectivity, potency for VEGFRs, and robust nonclinical activity may afford broad opportunities for axitinib to improve cancer therapy.
Expression of wild-type and mutant p53 proteins by recombinant vaccinia viruses (1992)

To facilitate the purification of wild type p53 protein, we established a recombinant p53 vaccinia viral expression system. Using this efficient eukaryotic expression vector, we found that the expressed p53 proteins retained their specific structural characteristics. A comparison between wild type and mutant p53 proteins showed the conservation of the typical subcellular localization and the expression of specific antigenic determinants. Furthermore, wild type p53 exhibited a typical binding with large T antigen, whereas no binding was detected with mutant p53. Both wild type and mutant p53 proteins were highly stable and constituted 5-7% of total protein expressed in the infected cells. These expression recombinant viruses offer a simple, valuable system for the purification of wild type and mutant p53 proteins that are expressed abundantly in eukaryotic cells.
Posterior parietal association cortex of the monkey: command functions for operations within extrapersonal space (1975)

Experiments were made on the posterior parietal association cortical areas 5 and in 17 hemispheres of 11 monkeys, 6 M. mulatta and 5 M. arctoides. The electrical signs of the activity of single cortical cells were recorded with microelectrodes in waking animals as they carried out certain behavioral acts in response to a series of sensory cues. The behavioral paradigms were one for detection alone, and a second for detection plus projection of the arm to contact a stationary or moving target placed at arm's length. Of the 125 microelectrode penetrations made, 1,451 neurons were identified in terms of the correlation of their activity with the behavioral acts and their sensitivity or lack of it to sensory stimuli delivered passively; 180 were studied quantitatively. The locations of cortical neurons were identified in serial sections; 94 penetrations and 1,058 neurons were located with certainty. About two-thirds of the neurons of area 5 were activated by passive rotation of the limbs at their joints; of these, 82% were related to single, contralateral joints, 10% to two or more contralateral joints, 6% to ipsilateral, and 2% to joints on both sides of the body. A few of the latter were active during complex bodily postures. A large proportion of area 5 neurons were relatively insensitive to passive joint rotations, as compared with similar neurons of the postcentral gyrus, but were driven to high rates of discharge when the same joint was rotated during an active movement of the animal...
High-speed, low-crosstalk chip holder for Josephson integrated circuits (1982)

Describes the construction and performance of a compact chip mount for making multiple, high-speed, low-crosstalk contacts to a Josephson integrated circuit. The mount has a rise time of about 32 ps and worst case crosstalk between lines of -33 dB.
Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors. (1993)

Recent evidence indicates that many more genes than the currently known oncogenes may undergo amplification in tumors. We have developed a new technique, Comparative Genomic Hybridization (CGH), which allows rapid detection of DNA amplification anywhere in the tumor genome and maps the amplified sequences on normal chromosomes. CGH is based on a competitive in situ hybridization of differentially labeled tumor DNA and normal DNA to a normal human metaphase spread. Regions of gain of DNA sequences are seen as an increased color ratio of two fluorochromes used to detect the labeled DNAs. Over 20 different regions of amplification have been identified using CGH.
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. (1982)

On the basis of preceding studies showing that tumor-induced, T cell-mediated immunosuppression serves as an obstacle to adoptive immunotherapy of the Meth A fibrosarcoma, it was predicted that cyclophosphamide treatment of tumor bearers would remove this obstacle and allow passively transferred immune T cells to cause tumor regression. It was found that infusion of immune spleen cells alone had no effect on tumor growth, and cyclophosphamide alone caused a temporary halt in tumor progression. In contrast, combination therapy consisting of intravenous injection of 100 mg/kg of cyclophosphamide followed 1 h later by intravenous infusion of tumor-immune spleen cells caused small, as well as large tumors, to completely and permanently regress. Tumor regression caused by combination therapy was completely inhibited by intravenous infusion of splenic T cells from donors with established tumors, but not by spleen cells from normal donors. These suppressor T cells were eliminated from the spleen by treating the tumor-bearing donors with 100 mg/kg of cyclophosphamide. Immune T cells, in contrast, were resistant to this dose of cyclophosphamide. These results show that failure of intravenously-infused, tumor-sensitized T cells to cause regression of the Meth A fibrosarcoma growing in its syngeneic or semi-syngeneic host is caused by the presence of a tumor-induced population of cyclophosphamide-sensitive suppressor T cells.
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. (1994)

Fibroblast cell lines, designated R- and W cells, were generated, respectively, from mouse embryos homozygous for a targeted disruption of the Igf1r gene, encoding the type 1 insulin-like growth factor receptor, and from their wild-type littermates. W cells grow normally in serum-free medium supplemented with various combinations of purified growth factors, while pre- and postcrisis R- cells cannot grow, as they are arrested before entering the S phase. R- cells are able to grow in 10% serum, albeit more slowly than W cells, and with all phases of the cell cycle being elongated. An activated Ha-ras expressed from a stably transfected plasmid is unable to overcome the inability of R- cells to grow in serum-free medium supplemented with purified clones. Nevertheless, even in the presence of serum, R- cells stably transfected with Ha-ras, alone or in combination with simian virus 40 large T antigen, fail to form colonies in soft agar. Reintroduction into R- cells (or their derivatives) of a plasmid expressing the human insulin-like growth factor I receptor RNA and protein restores their ability to grow with purified growth factors or in soft agar. The signaling pathways participating in cell growth and transformation are discussed on the basis of these results.
Interference Alignment and Spatial Degrees of Freedom for the K User Interference Channel (2008)

We show that the sum capacity of the K user frequency selective (or time-varying) interference channel is C(SNR) = (K/2) log(SNR) +o(log(SNR)) meaning that the channel has a total of K/2 degrees of freedom per orthogonal time and frequency dimension. Linear schemes of interference alignment and zero forcing suffice to achieve all the degrees of freedom and multi-user detection is not required.
Integrins and other adhesion molecules involved in melanocytic tumor progression (1995)

Recent investigations have reported changes in the expression of cell surface adhesion molecules associated with melanoma progression from in situ to invasive to metastatic tumors, including the upregulation of the integrins alpha v beta 3, alpha 3 beta 1, alpha 4 beta 1, and alpha 5 beta 1, downregulation of alpha 6 beta 1, and enhanced expression of intercellular adhesion molecule-1, MUC18, and CD44. Current research is now focused on the function of these adhesion molecules in facilitating melanoma invasion, metastasis and evasion of lysis by effector cells, and the mechanisms involved in controlling the adhesion molecule activation state and signal transduction.
Behavior of surface peroxo species in the photoreactions at titanium dioxide (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBehavior of surface peroxo species in the photoreactions at titanium dioxideMartine Ulmann, Norma R. De Tacconi, and Jan AugustynskiCite this: J. Phys. Chem. 1986, 90, 24, 6523–6530Publication Date (Print):November 1, 1986Publication History Published online1 May 2002Published inissue 1 November 1986https://doi.org/10.1021/j100282a022RIGHTS & PERMISSIONSArticle Views407Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts
Mixture analysis by triple-quadrupole mass spectrometry: metabolic profiling of urinary carboxylic acids. (1982)

In this new method for profiling urinary carboxylic acids, lyophilized urine samples are analyzed directly with a triple-quadrupole mass spectrometer. Extraction, derivatization, and lengthy gas-chromatographic separation procedures are obviated by this approach. Total sample-preparation, instrument, and data-analysis time per sample is about 15 min. More than 100 different organic acids can be detected in a typical urine sample. All components of the solid urine residue are volatilized into the ion source of the mass spectrometer and converted to (M-1)- ions by reaction with OH- under chemical ionization conditions. Quadrupole 1 is set to transmit ions of a particular m/z ratio, which in turn collide with molecular nitrogen in quadrupole 2 and dissociate to smaller charged fragments. Carboxylic acid (M-1)- ions uniquely lose either CO2 (44 atomic mass units) or both H2O and CO2 (62 atomic mass units). Quadrupole 3 is set to pass only ions that have lost either 44 or 62 atomic mass units. Accordingly, the instrument specifically detects carboxylic acids in the urine matrix and no other components. Direct analysis of polyethylene glycols and their acidic metabolites in urine and serum of a burn patient treated with an antimicrobial cream having a polyethylene glycol base is also discribed.
Photooxidation of Diglycine in Confined Media. Application of the Microreactor Model for Spin-Correlated Radical Pairs in Reverse Micelles and Water-in-Oil Microemulsions (2005)

Time-resolved electron paramagnetic resonance spectra (X-band) of correlated radical pairs created in AOT reverse micelles and microemulsions are presented, simulated, and discussed using the microreactor model. The radicals are formed inside the water pool using photooxidation of diglycine by the excited triplet states of two different anthraquinone sulfonate salts. Water pool size and temperature effects on the spectra are reported, and the simulations allow for extraction of the diffusion coefficient in the interior, which monotonically increases with water pool size. The data directly correlate with the diffusional properties of correlated radical pairs in regular aqueous micelle solutions studied previously by similar methods. Competition between H-atom abstraction and electron transfer is observed with anthraquinone sulfonate, but electron transfer is the only reaction pathway observed when anthraquinone disulfonate triplet state is the sensitizing species.
Engineering of a superhelicase through conformational control (2015)

Conformational control of biomolecular activities can reveal functional insights and enable the engineering of novel activities. Here we show that conformational control through intramolecular cross-linking of a helicase monomer with undetectable unwinding activity converts it into a superhelicase that can unwind thousands of base pairs processively, even against a large opposing force. A natural partner that enhances the helicase activity is shown to achieve its stimulating role also by selectively stabilizing the active conformation. Our work provides insight into the regulation of nucleic acid unwinding activity and introduces a monomeric superhelicase without nuclease activities, which may be useful for biotechnological applications.
Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training (2008)

We describe a new ab initio algorithm, GeneMark-ES version 2, that identifies protein-coding genes in fungal genomes. The algorithm does not require a predetermined training set to estimate parameters of the underlying hidden Markov model (HMM). Instead, the anonymous genomic sequence in question is used as an input for iterative unsupervised training. The algorithm extends our previously developed method tested on genomes of Arabidopsis thaliana, Caenorhabditis elegans, and Drosophila melanogaster. To better reflect features of fungal gene organization, we enhanced the intron submodel to accommodate sequences with and without branch point sites. This design enables the algorithm to work equally well for species with the kinds of variations in splicing mechanisms seen in the fungal phyla Ascomycota, Basidiomycota, and Zygomycota. Upon self-training, the intron submodel switches on in several steps to reach its full complexity. We demonstrate that the algorithm accuracy, both at the exon and the whole gene level, is favorably compared to the accuracy of gene finders that employ supervised training. Application of the new method to known fungal genomes indicates substantial improvement over existing annotations. By eliminating the effort necessary to build comprehensive training sets, the new algorithm can streamline and accelerate the process of annotation in a large number of fungal genome sequencing projects.
Purity assessment of multiwalled carbon nanotubes by Raman spectroscopy (2007)

Carbonaceous purity assessment for chemical vapor deposition multiwalled carbon nanotubes (MWNTs) using Raman spectroscopy was investigated. Raman spectroscopy was performed on a reference sample set containing predetermined ratios of MWNTs and representative synthesis by-products. Changes in the characteristic Raman peak ratios (i.e., ID∕IG, IG′∕IG, and IG′∕ID) as a function of MWNT content were measured. Calibration curves were generated from the reference samples and used to evaluate MWNTs synthesized under different conditions with varying purity. The efficacy of using Raman spectroscopy in conjunction with thermogravimetric analysis for quantitative MWNT purity assessment is discussed.
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations (2010)

The PheWAS software and code translation table are freely available at http://knowledgemap.mc.vanderbilt.edu/research.
Pendant arm Schiff base complexes of aluminium as ethylene polymerisation catalysts (1999)

The potentially tridentate Schiff base ligands [3,5-But2-2-(HO)C6H2CHNL] 1, on reaction with Me3Al at room temperature, afford the complexes [(3,5-But2-2-(O)C6H2CHNL)AlMe2] [L = CH2CH2NMe2 2a, (2-PhO)C6H4 2b, 2-CH2C5H4N 2c and 8-C9H6N (quinoline) 2d], 2a and 2c have been characterised crystallographically; further reaction of the dimethyl compounds with B(C6F5)3 affords the cationic systems [(3,5-But2-2-(O)C6H2CHNL)AlMe]+ 3a–d of which 3a and 3b are ethylene polymerisation catalysts.
Real-time spectral interferometry probes the internal dynamics of femtosecond soliton molecules (2017)

Solitons, particle-like excitations ubiquitous in many fields of physics, have been shown to exhibit bound states akin to molecules. The formation of such temporal soliton bound states and their internal dynamics have escaped direct experimental observation. By means of an emerging time-stretch technique, we resolve the evolution of femtosecond soliton molecules in the cavity of a few-cycle mode-locked laser. We track two- and three-soliton bound states over hundreds of thousands of consecutive cavity roundtrips, identifying fixed points and periodic and aperiodic molecular orbits. A class of trajectories acquires a path-dependent geometrical phase, implying that its dynamics may be topologically protected. These findings highlight the importance of real-time detection in resolving interactions in complex nonlinear systems, including the dynamics of soliton bound states, breathers, and rogue waves.