gebhart/patrepeval huggingface dataset:
A Multicomputer System with Dynamic Architecture (1979)

This paper considers the organization of certain multicomputer systems with a particular type of dynamic architecture. The system allows one to reconfigure via software available hardware resources (widths of processors, memories, and I/O units), forming computers with different word sizes. A multicomputer system is formed from identical dynamic computer groups. Each group may assume a variety of architectural states which are distinct from each other by the number and sizes of concurrent computers. To construct one dynamic computer group, one uses a universal building module, an 8-bit microprocessor on an LSI chip, and standard memory units. This paper considers basic principles of dynamic computer group implementation: organization of parallel (for words) and serial (for instructions) exchange between primary memory and processor, automatic variation of the time intervals assigned for operations which are executed in differently sized computers, formation of the processor with variable word size, switching from one architectural state to another, scheduling of the memory, and task synchronization.
Inhibition of Listeria monocytogenes by monoacylglycerols synthesized from coconut oil and milkfat by lipase-catalyzed glycerolysis (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of Listeria monocytogenes by monoacylglycerols synthesized from coconut oil and milkfat by lipase-catalyzed glycerolysisLih Ling. Wang, Bao Kang. Yang, Kirk L. Parkin, and Eric A. JohnsonCite this: J. Agric. Food Chem. 1993, 41, 6, 1000–1005Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jf00030a033https://doi.org/10.1021/jf00030a033research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hyaluronan and Angiogenesis (2007)

Remodelling tissues, in both normal and pathological situations, show a greatly increased synthesis and turnover of hyaluronan. An essential part of these processes is new blood vessel formation. Whereas native hyaluronan has been reported to inhibit angiogenesis in vivo, partial degradation products (4-25 disaccharide units) have been found to stimulate angiogenesis in several in vivo systems. Examination of the effect of hyaluronan and its oligosaccharides on cultured cells suggests that these effects are due to the direct action of hyaluronan on endothelial cells. Native HA inhibits endothelial cell proliferation and disrupts cell-cell/cell-substrate interactions at physiological concentration. Angiogenic oligosaccharides induce both endothelial proliferation and migration, possibly via a receptor-mediated mechanism. Thus the metabolic state of hyaluronan could have profound effects on tissue neovascularization.
CORRECTION BY HYALURONIDASE OF THE INTERSTITIAL TISSUE TRANSPORT DEFECT DURING SHOCK (1975)

We have demonstrated a defect in tissue perfusion during hemorrhagic shock in dogs that is due in part to poor capillary flow, and in part to a defect in interstitial tissue diffusion. Treatment with whole blood alone improves capillary flow but diffusion remains defective. The use of hyaluronidase appears to correct the interstitial diffusion defect observed during shock.
Force Constants of the Metaborate Ion in Alkali Halides (1972)

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An 18-Base-Pair Sequence in the Mouse Proα1(II) Collagen Gene Is Sufficient for Expression in Cartilage and Binds Nuclear Proteins That Are Selectively Expressed in Chondrocytes (1996)

The molecular mechanisms by which mesenchymal cells differentiate into chondrocytes are still poorly understood. We have used the gene for a chondrocyte marker, the proalpha1(II) collagen gene (Col2a1), as a model to delineate a minimal sequence needed for chondrocyte expression and identify chondrocyte-specific proteins binding to this sequence. We previously localized a cartilage-specific enhancer to 156 bp of the mouse Col2a1 intron 1. We show here that four copies of a 48-bp subsegment strongly increased promoter activity in transiently transfected rat chondrosarcoma (RCS) cells and mouse primary chondrocytes but not in 10T1/2 fibroblasts. They also directed cartilage specificity in transgenic mouse embryos. These 48 bp include two 11-bp inverted repeats with only one mismatch. Tandem copies of an 18-bp element containing the 3' repeat strongly enhanced promoter activity in RCS cells and chondrocytes but not in fibroblasts. Transgenic mice harboring 12 copies of this 18-mer expressed luciferase in ribs and vertebrae and in isolated chondrocytes but not in noncartilaginous tissues except skin and brain. In gel retardation assays, an RCS cell-specific protein and another closely related protein expressed only in RCS cells and primary chondrocytes bound to a 10-bp sequence within the 18-mer. Mutations in these 10 bp abolished activity of the multimerized 18-bp enhancer, and deletion of these 10 bp abolished enhancer activity of 465- and 231-bp intron 1 segments. This sequence contains a low-affinity binding site for POU domain proteins, and competition experiments with a high-affinity POU domain binding site strongly suggested that the chondrocyte proteins belong to this family. Together, our results indicate that an 18-bp sequence in Col2a1 intron 1 controls chondrocyte expression and suggest that RCS cells and chondrocytes contain specific POU domain proteins involved in enhancer activity.
Impedances of Bellows Corrugations (1987)

The longitudinal and transverse impedances of the bellows corrugations are analyzed systematically. Formulae are given so that, in the study of instabilities and energy losses, the impedances can be computed without resort to running a time consuming code like TBCI. The effect of many corrugations versus one corrugation is discussed.
Carbohydrate metabolism of the rat c6 glioma. an in vivo13c and in vitro1h magnetic resonance spectroscopy study (1988)

Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C]lactic acid, [1-13C]glycogen, and [4-13C], [3-13C], and [2-13C]glutamate/glutamine. Lactate levels of in vivo gliomas increased and reached steady state levels during [1-13C]glucose infusion, and decreased following termination of infusion. Complementary in vitro studies using supernatant media collected from C6 glioma cells incubated with media containing [1-13C] or [6-13C]glucose and glutamine were examined by 1H NMR spectroscopy. The [3-(13C/12C)]lactate ratios obtained from 1H spectra of supernatant media containing [1-13C]glucose revealed the percentage of glucose metabolized through the hexose monophosphate shunt to be 10.01 +/- 0.85% (n = 3), while similar measurements of media containing [6-13C]glucose and glutamine showed that glutaminolysis contributed 9.0 +/- 1.0% of total lactate production under these conditions. Enzymatic analysis of media determined lactate production to be 139 +/- 9 nmol per 10(6) cells per h (n = 4). These measurements demonstrate the ability of NMR to monitor brain tumor carbohydrate metabolism both in vitro and in vivo.
Multicenter trial of fluticasone propionate aqueous nasal spray in ragweed allergic rhinitis. (1994)

A 4-week multicenter, double-blind, placebo-controlled, parallel-group trial was carried out with 416 adults with ragweed allergic rhinitis to compare 200 micrograms of fluticasone propionate once daily and 100 micrograms of fluticasone propionate twice daily with placebo. Compared with placebo, both groups receiving fluticasone propionate had greater number of symptom free days (P < .01), lower median symptom scores (P < .01), and greater number of days not requiring rescue medications (P < .001). No significant differences for individual symptoms were found between the two fluticasone propionate groups except that those taking the twice daily dosage used less antihistamine (P < .01) and had greater number of days free of rescue medications (P < .05). Adverse events were comparable between the three groups. These results indicate that topical intranasal fluticasone propionate 200 micrograms once daily and 100 micrograms twice daily are both efficacious and well tolerated.
Assessing the Safety of Adjuvanted Vaccines (2011)

Despite the very low risk-to-benefit ratio of vaccines, fear of negative side effects has discouraged many people from getting vaccinated, resulting in reemergence of previously controlled diseases such as measles, pertussis, and diphtheria. Part of this fear stems from the lack of public awareness of the many preclinical and clinical safety evaluations that vaccines must undergo before they are available to the general public, as well as from misperceptions of what adjuvants are or why they are used in vaccines. The resultant "black box" leads to a preoccupation with rare side effects (such as autoimmune diseases) that are speculated, but not proven, to be linked to some vaccinations. The focus of this review article is to open this black box and provide a conceptual framework for how vaccine safety is traditionally assessed. We discuss the strengths and shortcomings of tools that can be and are used preclinically (in animal studies), translationally (in biomarker studies with human sera or cells), statistically (for disease epidemiology), and clinically (in the design of human trials) to help ascertain the risk of the infrequent and delayed adverse events that arise in relation to adjuvanted vaccine administration.
Predicting Vehicle Behaviors Over An Extended Horizon Using Behavior Interaction Network (2019)

Anticipating possible behaviors of traffic participants is an essential capability of autonomous vehicles. Many behavior detection and maneuver recognition methods only have a very limited prediction horizon that leaves inadequate time and space for planning. To avoid unsatisfactory reactive decisions, it is essential to count long-term future rewards in planning, which requires extending the prediction horizon. In this paper, we uncover that clues to vehicle behaviors over an extended horizon can be found in vehicle interaction, which makes it possible to anticipate the likelihood of a certain behavior, even in the absence of any clear maneuver pattern. We adopt a recurrent neural network (RNN) for observation encoding, and based on that, we propose a novel vehicle behavior interaction network (VBIN) to capture the vehicle interaction from the hidden states and connection feature of each interaction pair. The output of our method is a probabilistic likelihood of multiple behavior classes, which matches the multimodal and uncertain nature of the distant future. A systematic comparison of our method against two state-of-the-art methods and another two baseline methods on a publicly available real highway dataset is provided, showing that our method has superior accuracy and advanced capability for interaction modeling.
Full and Modulated Chemical Gating of Individual Carbon Nanotubes by Organic Amine Compounds (2001)

The adsorption of several types of alkylamine molecules on individual semiconducting and metallic single-walled carbon nanotubes is investigated by electrical transport measurements. The electrical conductance of semiconducting nanotubes changes drastically upon adsorption of butylamine and 3‘-(aminopropyl)triethoxysilane in the vapor phase. The amine groups in the molecules are electron donating and responsible for charge transfer to the semiconducting nanotubes, and thus, the observed electrical conductance change. Molecular adsorption on metallic single-walled nanotubes causes no significant change in the electrical conductance of the nanotube samples, consistent with earlier finding that the electrical properties of metallic nanotubes are relatively insensitive to molecular adsorption. Adsorption of the amine compounds on partial lengths of semiconducting nanotubes causes modulated chemical gating and intramolecular wire junctions that exhibits pronounced rectifying diode behavior. The physisorbed amine molecules desorb from nanotubes typically in 12 h, restoring the nonrectifying characteristics of the samples. Cross-linking of the hetero-functional 3‘-(aminopropyl)triethoxysilane molecules on partially exposed nanotubes via siloxane bridges leads to permanent intrananotube rectifiers.
Bronchial Thermoplasty for Asthma (2006)

BT is well tolerated in patients with asthma and results in decreased airway hyperresponsiveness that persists for at least 2 yr.
Effects of Tamoxifen Treatment on Plasma Lipids and Lipoprotein Lipid Composition (1990)

Concern has been raised that long term treatment with the antiestrogen tamoxifen might predispose women to the rapid development of cardiovascular disease. Since estrogen-induced changes in plasma lipids confer protection to females from coronary heart disease, we have examined the impact of tamoxifen on lipoprotein levels and composition on eight posmenopausal women. After 3 months of tamoxifen treatment (10 mg, twice daily), no significant changes were observed in either whole plasma triglyceride (pre-Rx, 137 +/- 59; post-Rx, 157 +/- 110 mg/dL) or cholesterol (pre-Rx, 193 +/- 23; post-Rx, 204 +/- 14 mg/dL); plasma free (unesterified) cholesterol (FC), however, fell significantly (pre-Rx, 66.5 +/- 6.5; post-Rx, 59.6 +/- 4.6 mg/dL; P less than 0.05). Since plasma lecithin (L) was unchanged, the FC/L ratio declined significantly to levels observed in healthy menstruating women (pre-Rx, 95 +/- 0.16; post-Rx, 0.74 +/- 0.12 molar ratio; P less than 0.025). In low density lipoprotein (LDL), the concentrations of cholesterol and FC and the FC/L ratio all fell significantly (P less than 0.025, P less than 0.05, and P less than 0.025, respectively). Despite a tendency for high density lipoprotein2 cholesterol (HDL2-C) to increase (pre-Rx, 9.7 +/- 3.6; post-Rx, and 14.4 +/- 13.3 mg/dL; P less than 0.4) and phosphoinositol to fall, there were few clear-cut alterations in either HDL2 or HDL3 surface or core lipid composition. The combination of reduced HDL3 lysolecithin (P less than 0.025) associated with a posttreatment trend toward increased triglyceride/cholesterol esters ratios in both HDL subfractions are findings consistent with tamoxifen-induced inhibition of hepatic lipase. These changes in lipoprotein composition together with the fall in LDL cholesterol and increase in sex hormone-binding globulin (P less than 0.005) indicate that tamoxifen acts as an estrogen agonist on the liver. Since elevated LDL cholesterol levels and qualitatively altered lipoproteins enriched in FC are both associated with increased coronary risk, the improvement noted in these parameters after tamoxifen should allay to some degree anxiety about its use with regard to cardiovascular risk.
Template-Directed Synthesis of Novel, Nucleic Acid-Like Structures (1985)

In studying the origins of life, it is important to examine reactions of substrate mixtures that could plausibly have accumulated on the primitive earth. Nucleoside diphosphates would probably have been synthesized along with the standard nucleotides under prebiotic conditions. For these reasons, the template-directed reactions of activated derivatives of these diphosphates, alone or mixed with activated nucleotides, were investigated. An activated derivative of deoxyguanosine 3',5'-diphosphate condensed efficiently on a polycytidylate template to give oligonucleotide analogues in which each 3',5'-phosphodiester bond was replaced by a pyrophosphate linkage. Oligomers were formed even in the absence of a template, but much more slowly. Template-directed condensation occurred also with an analogous deoxyadenosine derivative on polyuridylic acid and with an analogous acycloguanosine derivative on polycytidylic acid.
Inhibition of Human Immunodeficiency Virus Type 1 Activity by Purified Human Breast Milk Mucin (MUC1) in an Inhibition Assay (2007)

It has been reported that breast-feeding is responsible for approximately 40% of the HIV transmissions from HIV-positive mothers to children. Human breast milk, however, is known to contain numerous biologically active components which protect breast-fed infants against bacteria, viruses, and toxins. The purpose of this study was to purify and characterize breast milk mucin and to determine its anti-HIV-1 activity in an HIV inhibition assay. Sepharose CL-4B column chromatography and caesium chloride isopycnic density gradient purification were used to isolate and purify the mucin. Following Western blotting and amino acid analysis, an HIV-1 inhibition assay was carried out to determine the anti-HIV-1 activity of crude breast milk and purified milk mucin (MUC1) by incubating them with HIV-1 prior to infection of the human T lymphoblastoid cell line (CEM SS cells). SDS-PAGE analysis of the mucin, together with its amino acid composition and Western blotting, suggested that this purified mucin from human breast milk was MUC1. The HIV inhibition assay revealed that while the purified milk mucin (MUC1) inhibited the HIV-1 activity by approximately 97%, there was no inhibition of the HIV-1 activity by crude breast milk. Although the reason for this is not clear, it is likely that because the MUC1 in crude milk is enclosed by fat globules, there may not be any physical contact between the mucin and the virus in the crude breast milk. Thus, there is a need to free the mucin from the fat globules for it to be effective against the virus.
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles (2015)

Iron oxide nanoparticles (IONPs) have been extensively used during the last two decades, either as effective bio-imaging contrast agents or as carriers of biomolecules such as drugs, nucleic acids and peptides for controlled delivery to specific organs and tissues. Most of these novel applications require elaborate tuning of the physiochemical and surface properties of the IONPs. As new IONPs designs are envisioned, synergistic consideration of the body's innate biological barriers against the administered nanoparticles and the short and long-term side effects of the IONPs become even more essential. There are several important criteria (e.g. size and size-distribution, charge, coating molecules, and plasma protein adsorption) that can be effectively tuned to control the in vivo pharmacokinetics and biodistribution of the IONPs. This paper reviews these crucial parameters, in light of biological barriers in the body, and the latest IONPs design strategies used to overcome them. A careful review of the long-term biodistribution and side effects of the IONPs in relation to nanoparticle design is also given. While the discussions presented in this review are specific to IONPs, some of the information can be readily applied to other nanoparticle systems, such as gold, silver, silica, calcium phosphates and various polymers.
Manipulating the future (1992)

This paper introduces a predictor based visual feedback aid for navigating through virtual environments using velocity control. The predictor indicates to the user where and how fast he or she is travelling and has a direct manipulation feel to it. Experiences using the predictor to navigate over digital terrain maps are discussed, which show it to be an aide in learning to use velocity control and in creating smooth flight paths over thinned wire frame representation of a scene for subsequent single frame animation. Measurements of performance in using the predictor to fly through a tube scene show a benefit for the less experienced users.
Chiral Arylaminophosphonium Barfates as a New Class of Charged Brønsted Acid for the Enantioselective Activation of Nonionic Lewis Bases (2009)

Heterochiral [7.7]-P-spirocyclic arylaminophosphonium barfates have been designed as a novel charged, cationic Brønsted acid catalyst, and their catalytic and stereocontrolling abilities have been clearly demonstrated in the development of the unprecedented, highly enantioselective conjugate addition of arylamines to nitroolefins. This study uncovers a new function of chiral tetraaminophosphonium cations and its potential synthetic utility, thereby providing a new avenue to the molecular design of chiral charged Brønsted acid catalysts and their applications.
Estrogen and progesterone receptors status in the prediction of response of breast cancer to endocrine therapy (preliminary report). (1986)

The authors selected 263 ER cases and 224 ER/PgR cases for receptor status analysis from 1548 breast cancer tissues assayed. 30 Operating-theatres address their breast frozen specimens at our laboratory and thanks to this wide cooperation, we can perform the statistical analysis and relationship with very good reliability. In our experience we observed that the response to hormonal therapy is present in 50% of the cases containing ER concentrations up to 100 fmol/mg of proteins, and in 74% of the cases with ER concentrations more of 100 fmol/mg of proteins. Considering the presence of both receptors (ER+/PgR+) we observed the response rate to hormonal treatment in 76% of the cases while in 9% of the cases the status is ER/PgR negative. The cases classified ER negative and PgR positive demonstrated a response rate of 28%, 7 out of 26 cases ER+/PgR- responded to hormonal therapy. In this last situation, in addition to experienced hypotheses, the authors believe it is important to examine sonographically the ovaries, because the presence of a functional ovarian cyst could influence the saturation of receptorial sites.