gebhart/patrepeval huggingface dataset:
<title>New anti-spam filter based on data mining and analysis of email security</title> (2003)

One main technical means of anti-Spam is to build filters in email transfer route. However, the design of many junk mail filters hasn't made use of the whole security information in an email, which exists mostly in mail header rather than in the text and accessory. In this paper, data mining based on rough sets is introduced to design a new anti-Spam filter. Firstly, by recording and analyzing the header of every collected email sample, we get all necessary original raw data. Next, by selecting and computing features from the original header data, we obtain our decision table including several condition attributes and one decision attribute. Then, a data mining technique based on rough sets, which mainly includes relative reduction and rule generation, is introduced to mine this decision table. And we obtain some useful anti-Spam knowledge from all the email headers. Finally, we have made tests by using our rules to judge different mails. Tests demonstrate that when mining on selected baleful email corpus with specific Spam rate, our anti-Spam filter has high efficiency and high identification rate. By mining email headers, we can find potential security problems of some email systems and cheating methods of Spam senders.
Court Reconstruction for Camera Calibration in Broadcast Basketball Videos (2015)

We introduce a technique of calibrating camera motions in basketball videos. Our method particularly transforms player positions to standard basketball court coordinates and enables applications such as tactical analysis and semantic basketball video retrieval. To achieve a robust calibration, we reconstruct the panoramic basketball court from a video, followed by warping the panoramic court to a standard one. As opposed to previous approaches, which individually detect the court lines and corners of each video frame, our technique considers all video frames simultaneously to achieve calibration; hence, it is robust to illumination changes and player occlusions. To demonstrate the feasibility of our technique, we present a stroke-based system that allows users to retrieve basketball videos. Our system tracks player trajectories from broadcast basketball videos. It then rectifies the trajectories to a standard basketball court by using our camera calibration method. Consequently, users can apply stroke queries to indicate how the players move in gameplay during retrieval. The main advantage of this interface is an explicit query of basketball videos so that unwanted outcomes can be prevented. We show the results in Figs. 1, 7, 9, 10 and our accompanying video to exhibit the feasibility of our technique.
Skeletal Myogenic Differentiation of Mesenchymal Stem Cells Isolated from Human Umbilical Cord Blood (2004)

Human umbilical cord blood (UCB) has been regarded as an alternative source for cell transplantation and cell therapy because of its hematopoietic and nonhematopoietic (mesenchymal) potential. Although there has been debate about whether mesenchymal stem cells (MSCs) are invariably present in UCB, several reports showed that MSC-like cells could be consistently derived from human UCB and, moreover, could differentiate into various cells of a mesodermal origin. However, it remains unclear whether these UCB-derived MSCs are also capable of differentiating into skeletal muscle cells. In this study, we isolated MSCs from human UCB and induced them to differentiate into skeletal muscle cells. During cell culture expansion, UCB-derived mononuclear cells gave rise to adherent layers of fibroblast-like cells expressing MSC-related antigens such as SH2, SH3, alpha-smooth muscle actin, CD13, CD29, and CD49e. More important, when these UCB-derived MSCs were incubated in promyogenic conditions for up to 6 weeks, they expressed myogenic markers in accordance with myogenic differentiation pattern. Both flow cytometric and reverse transcriptase-polymerase reaction analyses showed that two early myogenic markers, MyoD and myogenin, were expressed after 3 days of incubation but not after 2 weeks. At week 6, more than half of UCB-derived MSCs expressed myosin heavy chain, a late myogenic marker. Our results demonstrate that UCB-derived MSCs possess a potential of skeletal myogenic differentiation and also imply that these cells could be a suitable source for skeletal muscle repair and a useful tool of muscle-related tissue engineering.
The round complexity of secure protocols (1990)

In a network of n players, each player i having private input zi, we show how the players can collaboratively evaluate a function f(zl, ..., zn) in a way that does not compromise the privacy of the players' inputs, and yet requires only a constant number of rounds of interaction.
A Novel Optical Microring Resonator Accelerometer (2007)

A unique optical accelerometer based on a microring resonator fabricated on a flexible substrate is experimentally demonstrated and its performance analyzed. This accelerometer measures the applied acceleration by measuring the shift of the resonant wavelength of the flexible microring resonator. The measured sensitivity of 31 pm/g is in accordance with our calculations. Some schemes of tailoring the sensitivity and the dynamic range are also suggested.
Characterization of HPSE Gene Single Nucleotide Polymorphisms in Jewish Populations of Israel (2006)

Heparanase is a mammalian endoglucuronidase responsible for heparan sulfate (HS) degradation. HS is a major constituent of the extracellular matrix (ECM) and HS-degrading activity plays a decisive role in fundamental biological processes associated with remodeling of the ECM, such as cancer metastasis, angiogenesis and inflammation. There is great interest in the prospect of genome-wide association studies to identify genetic factors underlying complex diseases. It is important to establish a detailed description of the heparanase (HPSE) gene single nucleotide polymorphisms (SNPs). In this study, four Israeli Jewish populations (Ashkenazi, North African, Mediterranean and Near Eastern) were examined for 7 HPSE gene SNPs. Four out of 7 SNPs (rs4693608, db11099592, rs4364254, db6856901) were found to be polymorphic. Population comparisons revealed significant differences in SNPs allele frequency between Near Eastern and each of the other three populations. Genotype and allele frequencies in Jewish populations were different from non-Jewish populations, except for a certain similarity to Caucasians. Although the distance between SNPs is relatively small, the db11099592 SNP was in linkage disequilibrium (LD) only with the proximal SNP rs4693608. LD between distal SNPs rs4364254 and db6856901 was found only in Mediterraneans and North Africans. The current study provides a characterization of the normally occurring HPSE gene SNPs in different populations. This information is obligatory for further studies on the linkage between these SNPs and heparanase expression and function in various pathological processes, primarily cancer progression.
Effect of Maillard reaction products on protein digestion. In vitro studies (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of Maillard reaction products on protein digestion. In vitro studiesRickard E. Oste, Arne Dahlqvist, Hans Sjoestroem, Ove Noren, and Raya MillerCite this: J. Agric. Food Chem. 1986, 34, 2, 355–358Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/jf00068a051https://doi.org/10.1021/jf00068a051research-articleACS PublicationsRequest reuse permissionsArticle Views364Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Crystal Structure of Human Procathepsin K (1998)

Cathepsin K is a cysteine protease present in human osteoclasts that plays an important role in bone resorption. Cathepsin K is synthesized as an inactive proenzyme and activated under conditions of low pH. Autoproteolytic processing of the N-terminal 99 amino acid propeptide produces the active, mature form of cathepsin K. It is presumed that the activation of procathepsin K in vivo occurs in the bone resorption pit, which has a low-pH environment. We have determined the structure of human procathepsin K at 2.8 A resolution. The structure of the mature enzyme domain within procathepsin K is virtually identical to that of mature cathepsin K. The fold of the propeptide of procathepsin K is similar to that observed in procathepsins B and L despite differences in length and sequence. A portion of the propeptide occupies the active site cleft of cathepsin K. Hydrophobic interactions, salt bridges, and hydrogen-bonding interactions are observed in the structure of the propeptide and between the propeptide and the mature enzyme of procathepsin K. These interactions suggest an explanation for the stability of the proenzyme. The structure of procathepsin K contributes to an understanding of the molecular basis of inhibition by the propeptide portion of the molecule and activation of this important member of the cysteine protease family.
Effects of linker chemistry on the pharmacokinetics of radioimmunoconjugates. (1998)

Radiolabeled monoclonal antibodies reactive with tumor-associated antigens can selectively deliver cytotoxic or diagnostic isotopes to malignant cells in vivo. To achieve maximum retention of radiolabel in tumor and a more rapid clearance of radioisotope from normal tissues, six linker immunoconjugates were evaluated in studies using nude mice and beagle dogs. All radioimmunoconjugates contained a mouse monoclonal IgG (QCI) reactive with human ferritin. Different chemical linkages were inserted between immunoglobulins and the radiolabeled chelate (DTPA). Three linkers (ITCB, DSS and BSOCOES) were stable in in vitro and in vivo studies. Three linkers (EGS, DST and DSP) were labile in in vitro and in vivo studies. Indium-111 labeled antiferritin-containing ITCB or DSS linker showed high uptake in human hepatoma xenografts in nude mice. In addition, long blood half-lives and higher normal liver uptakes were noted. Studies of whole body retention of radioimmunoconjugates showed approximately three-fold faster elimination of radioimmunoconjugates containing a labile linker (EGS). EGS linker is the labile linker with the highest therapeutic ratio: higher tumor uptake, but low normal liver uptake and a shortened blood half-life of the radioimmunoconjugate. The differences in normal tissue uptake (liver) between EGS and ITCB were confirmed in beagle dogs. Urine elimination studies and incubation or radioimmunoconjugates in serum or tissue homogenates of tumor, liver or muscle, showed that enzymes in serum and liver homogenates were able to cleave the labile linkers, which led to a more rapid elimination of low molecular weight radioactive metabolites in urine. The metabolism of linker radioimmunoconjugates in tumor was less effective. The labile linker DSP appears less useful because sulphydryl groups that are generated by cleavage of cause higher uptake radioactivity in normal kidney. Biodistribution studies in nude mice were confirmed by serial immunoscintigraphy studies on individual mice. The immunoscintigraphy studies are semi-quantitative only, but enable the use of lower numbers of experimental animals. This is of particular significance in large experimental animals such as beagle dogs. The labile linker approach can reduce normal tissue radiation exposure. The study also provides an example of preclinical optimization of radioimmunoconjugates. Continued use of the appropriate preclinical animal models will accelerate more successful applications of radioimmunoconjugates in cancer patients.
Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. (1994)

The effect of basic fibroblast growth factor (bFGF) administration on regional myocardial function and blood flow in chronically ischemic hearts was studied in 26 pigs instrumented with proximal circumflex coronary artery (LCX) ameroid constrictors. In 13 animals bFGF was administered extraluminally to the proximal left anterior descending (LAD) and LCX arteries with heparin-alginate beads and 13 other animal served as controls. bFGF-treated pigs showed a fourfold reduction in left ventricular infarct size compared to untreated controls (infarct size: 1.2 +/- 0.4% vs. 5.1 +/- 1.3% of LV mass, mean +/- SEM, P < 0.05). Percent fractional shortening (% FS) in the LCX area at rest was reduced compared with the LAD region in both bFGF and control pigs. However, there was better recovery in the LCX area after rapid pacing in bFGF-treated pigs (% FSLCX/% FSLAD, 22.9 +/- 7.3%-->30.5 +/- 8.5%, P < 0.05 vs. prepacing) than in controls (16.0 +/- 7.8%-->14.3 +/- 7.0%, P = NS). Furthermore, LV end-diastolic pressure rise with rapid pacing was less in bFGF-treated than control pigs (pre-pacing; pacing; post-pacing, 10 +/- 1; 17 +/- 3; 11 +/- 1* mmHg vs 10 +/- 1; 24 +/- 4; 15 +/- 1 mmHg, *P < 0.05 vs. control). Coronary blood flow in the LCX territory (normalized for LAD flow) was also better during pacing in bFGF-treated pigs than in controls. Thus, periadventitial administration of bFGF in a gradual coronary occlusion model in pigs results in improvement of coronary flow and reduction in infarct size in the compromised territory as well as in prevention of pacing-induced hemodynamic deterioration.
Feeder-free Derivation of Neural Crest Progenitor Cells from Human Pluripotent Stem Cells (2014)

Human pluripotent stem cells (hPSCs) have great potential for studying human embryonic development, for modeling human diseases in the dish and as a source of transplantable cells for regenerative applications after disease or accidents. Neural crest (NC) cells are the precursors for a large variety of adult somatic cells, such as cells from the peripheral nervous system and glia, melanocytes and mesenchymal cells. They are a valuable source of cells to study aspects of human embryonic development, including cell fate specification and migration. Further differentiation of NC progenitor cells into terminally differentiated cell types offers the possibility to model human diseases in vitro, investigate disease mechanisms and generate cells for regenerative medicine. This article presents the adaptation of a currently available in vitro differentiation protocol for the derivation of NC cells from hPSCs. This new protocol requires 18 days of differentiation, is feeder-free, easily scalable and highly reproducible among human embryonic stem cell (hESC) lines as well as human induced pluripotent stem cell (hiPSC) lines. Both old and new protocols yield NC cells of equal identity.
Optimal Coarsening of 3D Reservoir Models for Flow Simulation (2005)

Abstract We have developed a new constrained optimization approach to the coarsening of 3D reservoir models for flow simulation. The optimization maximally preserves a statistical measure of the heterogeneity of a fine scale model. Constraints arise from the reservoir fluids, well locations, pay/non-pay juxtaposition, and large scale reservoir structure and stratigraphy. The approach has been validated for a number of oil and gas projects, where flow simulation through the coarsened model is shown to provide an excellent approximation to high resolution calculations performed in the original model. The optimal layer coarsening is related to the analyses of Li and Beckner (2000), Li, Cullick and Lake (1995), and Testerman (1962). It differs by utilizing a more accurate measure of reservoir heterogeneity and by being based on recursive sequential coarsening, instead of sequential refinement. Recursive coarsening is shown to be significantly faster than refinement: the cost of the calculation scales as (NX·NY·NZ) instead of (NX·NY·NZ)[2]. The more accurate measure of reservoir heterogeneity is very important; it provides a more conservative estimate of the optimal number of layers than the analysis of Li et.al.. The latter is shown to be too aggressive and does not preserve important aspects of the reservoir heterogeneity. Our approach also differs from the global methods of Stern (1999) and Durlofsky (1994). It does not require the calculation of a global pressure solution and it does not require the imposition of large scale flow fields, which may bias the analysis, Fincham (2004). Instead, global flow calculations are retained only to validate the reservoir coarsening. Our approach can generate highly unstructured, variable resolution, computational grids. The layering scheme for these grids follows from the statistical analysis of the reservoir heterogeneity. Locally variable resolution follows from the constraints (reservoir structure, faults, well locations, fluids, pay/non-pay juxtaposition). Our reservoir simulator has been modified to allow a fine scale model to be initialized and further coarsened at run time. This has many advantages in that it provides both simplified and powerful workflows, which allow engineers and geoscientists to work with identical shared models.
Ultrasonic Nebulized in Comparison With Instilled Surfactant Treatment of Preterm Lambs (1996)

To evaluate the efficiency and distribution of ultrasonic nebulized versus instilled surfactant in the treatment of surfactant deficiency at varying degrees of maturation, twin or triplet lamb fetuses were delivered at 125 to 137 d gestational age and received nebulized natural surfactant (Neb Only), instilled surfactant followed by a second instilled dose (Inst/Inst), instilled surfactant followed by nebulized surfactant (Inst/Neb), or no surfactant (Control). The lambs were ventilated for 6 h. Twenty-eight lambs were categorized into two groups (low compliance versus moderate compliance) based on initial physiologic lung characteristics. Efficiency of deposition of nebulized surfactant directly correlated with the compliances and ventilatory efficiency indices measured at 15 min of age. The low-compliance group (Low Comp) had significantly lower efficiency of surfactant deposition (7.6 +/- 1.6%) than did the moderate-compliance group (Mod Comp) (23.4 +/- 2.5%) (p < 0.01). Overall, instilled surfactant had a reasonably homogeneous distribution, whereas nebulized surfactant had a less homogeneous distribution, except for the Low Comp, Inst/Neb group, which had a distribution pattern similar to that for instilled surfactant. The potential for nebulized surfactant therapy for respiratory distress syndrome (RDS) may be limited by the nonhomogeneous nature of ventilation in the preterm lung.
Gene delivery into malignant cells in vivo by a conjugated adenovirus/DNA complex. (1997)

Current viral delivery systems suffer from disadvantages that may limit the rate at which therapeutic gene expressing constructs can be tested both in vitro and in vivo. In this study, our focus was to develop a simple gene delivery system for the rapid and reproducible testing of therapeutic genes in cancer cells both in vitro and in vivo. We report here that a delivery system based on using a conjugated adenovirus in complex from with a DNA plasmid can be used for not only delivering genes in vitro but also for efficient and reproducible delivery in vivo. Replication defective adenoviral particles were chemically modified by covalent attachment of poly-L-lysine (PLL) to the viral capsid, allowing for direct interaction with DNA. The adenovirus/PLL conjugate (Adv/PLL) was used to deliver the plasmid pCMV/beta-gal to several different cancer cell lines (i.e., lung, cervical) in vitro and resulted in transduction efficiencies as high as 52% as determined by histochemical staining. On direct intralesional injection of the Adv/PLL/DNA complex into subcutaneous tumors, transduction efficiencies greater than 35% could also be achieved. As a result, this system provides a simple method for delivering and testing therapeutic genes in cells both in vitro and in vivo, prior to the further development of gene therapy vectors for both malignant and benign disease.
Epidemic methicillin-resistant Staphylococcus aureus (1988)

We contrast the experiences, in our Health Authority in South-East London, with the particular epidemic methicillin-resistant Staphylococcus aureus (the EMRSA) strain that has recently spread widely around London and South-East England, and with the other MRSA (OMRSA) strains encountered there. Our isolates of the EMRSA were identical by chromosomal restriction enzyme analysis, and the chromosomal and plasmid phenotypes were similar to those described in North London and Eastern Australia. Experimental phage-typing distinguished them from OMRSA encountered in 1984 to 1986. Between 1984 and 1985, the EMRSA caused increased infection and patient colonization compared to the years 1969 to 1983. A change in infection control procedures was usually required to control the EMRSA and in 1986 isolates had returned to their pre-1984 levels. Between 1984 and 1986 OMRSA were still encountered, but did not spread or require changes in infection control procedures. The distribution of other resistant isolates was examined; c 94% of neomycin-resistant isolates were in-patients or clinic patients. Forty-five different phage-type/antibiogram patterns were found in 88 isolates from 66 patients between 1982 and 1985, and patient clusters were uncommon. The ability of the EMRSA to spread is discussed and is probably not purely organism related. Our experience supports the contention that some MRSA are truly epidemic, whilst others do not behave in this manner.