gebhart/patrepeval huggingface dataset:
Real-time three-dimensional pickup and display system based on integral photography (1998)

A real-time three-dimensional (3-D) pickup and display setup called a Real-time IP system is proposed. In this system, erected real images of an object are formed by a GRIN lens array as element images, and are directly shot by a television camera. The video signal of a group of element images is transmitted to display device that combines a liquid crystal panel display and a convex micro-lens array, producing a color 3-D image in real-time. Full-color and autostereoscopic 3-D images with full-parallax can be observed. We confirmed the possibility of the 3-D television system.
Interferometric Synthetic Aperture Microscopy: Inverse Scattering for Optical Coherence Tomography (2006)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Tyler S. Ralston, Daniel L. Marks, P. Scott Carney, and Stephen A. Boppart, "Interferometric Synthetic Aperture Microscopy: Inverse Scattering for Optical Coherence Tomography," Optics & Photonics News 17(12), 25-25 (2006) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
<title>Microbiological estimate of parodontitis laser therapy efficiency</title> (1995)

In this work was carried out microbiological estimate the efficiency of ultraviolet and He-Ne laser radiation at the treatment of parodontitis. 90 persons was investigated with parodontitis of middle serious diagnosis. The optimal regimes of ultraviolet radiation influence on various micro-organisms discharged from pathologic tooth pocket (PTP) were determined. On the base of specils microflora composition study and data of microbic PTP dissemination owe may conclude that the complex He- Ne and ultraviolet laser radiation show the most pronounced antimicrobic effect.
Synthesis of Cellulose Adipate Derivatives (2011)

Cellulose esters containing adipates and other ester groups are synthesized by the reaction of commercially available cellulose esters in solution with the benzyl monoester of adipoyl chloride. The products, cellulose adipate esters in which the distal end of the adipate moiety is a benzyl ester, were easily converted to cellulose adipate derivatives by Pd-catalyzed hydrogenation. These cellulose adipate derivatives are promising biopolymers for drug delivery and other applications in which water-dispersion or swelling are desired.
DNA Hypermethylation of Cell Cycle (p15 and p16) and Apoptotic (p14, p53, DAPK and TMS1) Genes in Peripheral Blood of Leukemia Patients (2014)

Aberrant DNA methylation of tumor suppressor genes has been reported in all major types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. However, most of the previous reports did not show the extent of concurrent methylation of multiple genes in the four leukemia types. Here, we analyzed six key genes (p14, p15, p16, p53, DAPK and TMS1) for DNA methylation using methylation specific PCR to analyze peripheral blood of 78 leukemia patients (24 CML, 25 CLL, 12 AML, and 17 ALL) and 24 healthy volunteers. In CML, methylation was detected for p15 (11%), p16 (9%), p53 (23%) and DAPK (23%), in CLL, p14 (25%), p15 (19%), p16 (12%), p53 (17%) and DAPK (36%), in AML, p14 (8%), p15 (45%), p53 (9%) and DAPK (17%) and in ALL, p15 (14%), p16 (8%), and p53 (8%). This study highlighted an essential role of DAPK methylation in chronic leukemia in contrast to p15 methylation in the acute cases, whereas TMS1 hypermethylation was absent in all cases. Furthermore, hypermethylation of multiple genes per patient was observed, with obvious selectiveness in the 9p21 chromosomal region genes (p14, p15 and p16). Interestingly, methylation of p15 increased the risk of methylation in p53, and vice versa, by five folds (p=0.03) indicating possible synergistic epigenetic disruption of different phases of the cell cycle or between the cell cycle and apoptosis. The investigation of multiple relationships between methylated genes might shed light on tumor specific inactivation of the cell cycle and apoptotic pathways.
IL-23 and IL-12 Have Overlapping, but Distinct, Effects on Murine Dendritic Cells (2002)

IL-23 is a recently discovered heterodimeric cytokine that shares biological properties with proinflammatory cytokines. The biologically active heterodimer consists of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12. We have constructed single-chain IL-23 and IL-12 fusion proteins (IL-23-Ig and IL-12-Ig) and have compared the two recombinant proteins for effects on murine dendritic cells (DC). Here we show that the IL-23-Ig can bind a significant proportion of splenic DC of both the CD8alpha(-) and CD8alpha(+) subtypes. Furthermore, IL-23and IL-12-Ig exert biological activities on DC that are only in part overlapping. While both proteins induce IL-12 production from DC, only IL-23-Ig can act directly on CD8alpha(+) DC to promote immunogenic presentation of an otherwise tolerogenic tumor peptide. In addition, the in vitro effects of IL-23-Ig did not appear to require IL-12Rbeta2 or to be mediated by the production of IL-12. These data may establish IL-23 as a novel cytokine with major effects on APC.
Nucleolar organizer regions in cirrhosis and hepatocellular carcinoma. (1998)

The argyrophilic technique for staining proteins associated with nucleolar organizer regions (AgNOR's) was applied to 32 liver biopsy specimens. These included 10 normal livers, 10 cirrhosis, 10 hepatocellular carcinomas (HCC) and 2 cholangiocarcinomas. The range of the mean number of NORs per nucleus was 1.3-1.7 (95% CI: 1.4-1.6) for normal liver, 2.4-3.5 (2.8-3.2) for cirrhosis, 3.0-7.9 (3.7-5.6) for HCC and 4.0-4.2 (3.9-4.3) for cholangiocarcinoma. The difference observed was statistically significant. The AgNORs were small and discrete in normal and cirrhotic liver and relatively larger and scattered in distribution in HCC. These results indicate that both quantitative and qualitative analysis of AgNORs may be useful as an adjunct to routine haematoxylin and eosin stain to distinguish cirrhosis from HCC especially when the latter is well differentiated.
Linearity and Reflexivity in the Growth of Mathematical Knowledge (1989)

The Argument Recent studies in the philosophy of mathematics have increasingly stressed the social and historical dimensions of mathematical practice. Although this new emphasis has fathered interesting new perspectives, it has also blurred the distinction between mathematics and other scientific fields. This distinction can be clarified by examining the special interaction of the body and images of mathematics. Mathematics has an objective, ever-expanding hard core, the growth of which is conditioned by socially and historically determined images of mathematics. Mathematics also has reflexive capacities unlike those of any other exact science. In no other exact science can the standard methodological framework used within the discipline also be used to study the nature of the discipline itself. Although it has always been present in mathematical research, reflexive thinking has become increasingly central to mathematics over the past century. Many of the images of the discipline have been dictated by the increase in reflexive thinking which has also determined a great portion of the contemporary philosophy and historiography of mathematics.
DNase II and the Chk2 DNA Damage Pathway Form a Genetic Barrier Blocking Replication of Horizontally Transferred DNA (2006)

We have previously shown that DNA from dying tumor cells may be transferred to living cells via the uptake of apoptotic bodies and may contribute to tumor progression. DNA encoding H-ras(V12) and c-myc oncogenes may be transferred to the nucleus of the phagocyte but will only integrate and propagate in p53- and p21-deficient mouse embryonic fibroblasts, whereas normal cells are resistant to transformation. Here, we show that this protective mechanism (activation of p53 and p21 after uptake of apoptotic bodies) is dependent on DNA fragmentation, where inhibition of the caspase-activated DNase in the apoptotic cells, in conjunction with genetic ablation of lysosomal DNase II in the phagocytes, completely blocks p53 activation and consequently allows DNA replication of transferred DNA. We, therefore, suggest that there is a causal relationship between DNA degradation during apoptosis and p53 activation. In addition, we could further show that Chk2-/- cells were capable of replicating the hyg(R) gene taken up from engulfed apoptotic cells, suggesting involvement of the DNA damage response. These data show that the phagocytosing cell is sensing the degraded DNA within the apoptotic cell, hence preventing these genes from being replicated, probably through activation of the DNA damage response. We, therefore, hypothesize that DNase II together with the Chk2, p53, and p21 pathway form a genetic barrier blocking the replication of potentially harmful DNA introduced via apoptotic bodies, thereby preventing transformation and malignant development.
Evaluation of Several Organic Materials as Planarizing Layers for Lithographic and Etchback Processing (1989)

Several materials were surveyed as topographic substrate planarizing layers for use in optical lithography or in etchback processes that are used in the fabrication of multilevel metal-insulator structures. Two types of materials were examined: resins that were applied by spin coating and baked to enhance planarization, and liquid monomers that were applied by spin coating and hardened photochemically after an appropriate leveling period. The planarizing properties of the materials were compared by measuring their abilities to level 20-500 μm wide isolated square holes on Si substrates. Other relevant properties, such as etching resistance, uv absorbance and glass transition temperature, are reported and discussed.
The basic building blocks and evolution of CRISPR–Cas systems (2013)

CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) is an adaptive immunity system in bacteria and archaea that functions via a distinct self/non-self recognition mechanism that involves unique spacers homologous with viral or plasmid DNA and integrated into the CRISPR loci. Most of the Cas proteins evolve under relaxed purifying selection and some underwent dramatic structural rearrangements during evolution. In many cases, CRISPR-Cas system components are replaced either by homologous or by analogous proteins or domains in some bacterial and archaeal lineages. However, recent advances in comparative sequence analysis, structural studies and experimental data suggest that, despite this remarkable evolutionary plasticity, all CRISPR-Cas systems employ the same architectural and functional principles, and given the conservation of the principal building blocks, share a common ancestry. We review recent advances in the understanding of the evolution and organization of CRISPR-Cas systems. Among other developments, we describe for the first time a group of archaeal cas1 gene homologues that are not associated with CRISPR-Cas loci and are predicted to be involved in functions other than adaptive immunity.
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia (2007)

Mutations in the kinase domain (KD) of BCR-ABL are the most prevalent mechanism of acquired imatinib resistance in patients with chronic myeloid leukemia (CML). Here we examine predisposing factors underlying acquisition of KD mutations, evidence for acquisition of mutations before and during therapy, and whether the detection of a KD mutation universally implies resistance. We also provide a perspective on how the second-line Abl inhibitors dasatinib and nilotinib are faring in the treatment of imatinib-resistant CML, especially in relation to specific KD mutations. We discuss the growing importance of the multi-inhibitor-resistant 315T>I mutant and the therapeutic potential that a 315T>I inhibitor would have. Last, we assess the potential of Abl kinase inhibitor combinations to induce stable responses even in advanced CML and interpret the emerging data in the context of CML pathogenesis.
The ISSCR Guidelines for Human Embryonic Stem Cell Research (2007)

10.1126/science.1139337
Image Guided Depth Upsampling Using Anisotropic Total Generalized Variation (2013)

In this work we present a novel method for the challenging problem of depth image up sampling. Modern depth cameras such as Kinect or Time-of-Flight cameras deliver dense, high quality depth measurements but are limited in their lateral resolution. To overcome this limitation we formulate a convex optimization problem using higher order regularization for depth image up sampling. In this optimization an an isotropic diffusion tensor, calculated from a high resolution intensity image, is used to guide the up sampling. We derive a numerical algorithm based on a primal-dual formulation that is efficiently parallelized and runs at multiple frames per second. We show that this novel up sampling clearly outperforms state of the art approaches in terms of speed and accuracy on the widely used Middlebury 2007 datasets. Furthermore, we introduce novel datasets with highly accurate ground truth, which, for the first time, enable to benchmark depth up sampling methods using real sensor data.
Sentiment strength detection in short informal text (2010)

Abstract A huge number of informal messages are posted every day in social network sites, blogs, and discussion forums. Emotions seem to be frequently important in these texts for expressing friendship, showing social support or as part of online arguments. Algorithms to identify sentiment and sentiment strength are needed to help understand the role of emotion in this informal communication and also to identify inappropriate or anomalous affective utterances, potentially associated with threatening behavior to the self or others. Nevertheless, existing sentiment detection algorithms tend to be commercially oriented, designed to identify opinions about products rather than user behaviors. This article partly fills this gap with a new algorithm, SentiStrength, to extract sentiment strength from informal English text, using new methods to exploit the de facto grammars and spelling styles of cyberspace. Applied to MySpace comments and with a lookup table of term sentiment strengths optimized by machine learning, SentiStrength is able to predict positive emotion with 60.6% accuracy and negative emotion with 72.8% accuracy, both based upon strength scales of 1–5. The former, but not the latter, is better than baseline and a wide range of general machine learning approaches.
Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma (1985)

The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related to v-erbB but amplified in a manner that appeared to distinguish it from the gene for the EGF receptor. Molecular cloning of this DNA segment and nucleotide sequence analysis revealed the presence of two putative exons in a DNA segment whose predicted amino acid sequence was closely related to, but different from, the corresponding sequence of the erbB/EGF receptor. Moreover, this DNA segment identified a 5-kilobase transcript distinct from the transcripts of the EGF receptor gene. Thus, a new member of the tyrosine kinase proto-oncogene family has been identified on the basis of its amplification in a human mammary carcinoma.
Synthesis and structure of the chloride and nitrate inclusion complexes of [16-pyrimidinium crown-4]4+ (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of the chloride and nitrate inclusion complexes of [16-pyrimidinium crown-4]4+Roger E. Cramer, Vilma Fermin, Estelle Kuwabara, Ruby Kirkup, Mary Selman, Katsuyuki Aoki, Adegboye Adeyemo, and Hiroshi YamazakiCite this: J. Am. Chem. Soc. 1991, 113, 18, 7033–7034Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/ja00018a050https://doi.org/10.1021/ja00018a050research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Staphylococcal toxin induced preferential and prolongedin vivodeletion of innate-like B lymphocytes (2004)

Contributing to host defenses from the adaptive immune system, splenic marginal zone (MZ) B cells, with their preactivated state and special topographical location, serve essential roles as primary defenders from blood-borne microbes. From studies designed to define the immunologic impact of protein A of Staphylococcus aureus (SpA), a virulence factor with targeted B cell antigen receptor-binding properties, we found that within minutes of in vivo exposure, SpA became surface associated with B lymphocytes and induced trafficking. Within several hours, MZ were completely effaced of affected B cells. This was rapidly followed by massive B cell apoptosis, with accelerated preferential deletion of targeted MZ B cells and impaired responsiveness to T independent immunogens. Subsequently, the temporal recovery of MZ B cells was significantly delayed compared to peripheral follicular B cells (B-2 cells). These studies elucidate the cellular program induced by a natural toxin that is shown to be highly efficient at depleting innate-like B cells important for defense from systemic infection.
Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis (2009)

Cell-type specific regulation of a small number of growth factor signal transduction pathways generates diverse developmental outcomes. The zinc finger protein Churchill (ChCh) is a key effector of fibroblast growth factor (FGF) signaling during gastrulation. ChCh is largely thought to act by inducing expression of the multifunctional Sip1 (Smad Interacting Protein 1). We investigated the function of ChCh and Sip1a during zebrafish somitogenesis. Knockdown of ChCh or Sip1a results in misshapen somites that are short and narrow. As in wild-type embryos, cycling gene expression occurs in the developing somites in ChCh and Sip1a compromised embryos, but expression of her1 and her7 is maintained in formed somites. In addition, tail bud fgf8 expression is expanded anteriorly in these embryos. Finally, we found that blocking FGF8 restores somite morphology in ChCh and Sip1a compromised embryos. These results demonstrate a novel role for ChCh and Sip1a in repression of FGF activity.
Feasibility Study of a Human Papillomavirus E6 Oncoprotein Test for Diagnosis of Cervical Precancer and Cancer (2010)

In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.
Object-Based Video Representation for Remote Patient Monitoring (2006)

Object-based video representation plays an important role in remote patient monitoring built on video coding and Internet transmission. This paper introduces an object-based video representation method using two novel change detection techniques, and presents a demo system built upon ConferenceXP, where three types of video objects are constructed by exploiting the features in patient monitoring video. Our experimental results based on real-world data have shown that these techniques provide better foreground and background separation, higher coding efficiency, and improved performance in remote patient monitoring
Influence of intraocular lens haptic design on refractive error (2014)

Dr. Hoffer receives royalties for his book IOL Power, Slack, Inc., and formula royalties from all manufacturers using the Hoffer Q formula. No other author has a financial or proprietary interest in any material or method mentioned.
General Synthesis of Asymmetric Multi-Element Coupled-Transmission-Line Directional Couplers (1963)

An exact synthesis procedure is derived for a class of asymmetric multielement coupled-transmission-line directional couplers with any number of elements. It is based on the equivalence between the theory of the directional coupler and that of a stepped quarter-wavelength filter. This can be treated using Richards' theorem for the synthesis of transmission-line distributed networks, as described previously by Riblet. The method is extended to give a general expression for the input reflection coefficient of the stepped filter, which corresponds to the voltage coupling of the directional coupler. Explicit formulas for the parameters of two, three, four and five couplers are derived and the extension to larger number of elements is straightforward. Two and three element couplers have been designed on this theoretical basis, and show excellent agreement with theory, for example a three element coupler of 20 db /spl plusmn/ 0.5 db over a 6:1 bandwidth, and a two element coupler of 3.2 db /spl plusmn/ 0.85 db over a 6.7:1 bandwidth. It is possible to design a 3-db /spl plusmn/ 0.43 db-coupler for decade bandwidths using only four elements. The 3 db-couplers may be used as 90/spl deg/ hybrids by careful choice of reference planes in the output parts.