gebhart/patrepeval huggingface dataset:
Survey of the storage evolution (2004)

The storage market is in a state of transition on several fronts. This seems to be a time where noteworthy technologies are evolving that will have long-term impacts on information technology and high performance computing (HPC). Two of the more important evolutions in the storage arena are the serialization of storage access mechanisms, and efforts to access storage via IP networks. While these two efforts are not necessarily related, they are both seen by many storage vendors as defining trends in the industry. We focus on these two IO bus level evolutionary trends in particular, and how we can expect them to affect HPC users.
Stabilization of Battery Electrode/Electrolyte Interfaces Employing Nanocrystals with Passivating Epitaxial Shells (2014)

Chemical degradation at electrode/electrolyte interfaces in high-energy storage devices, such as Li-ion batteries, imposes durability challenges that affect their life and cost. In oxide electrodes, degradation is linked to the presence of redox active transition metals at the surface. Here, we demonstrate a strategy toward the stabilization of interfaces using core–epitaxial shell nanocrystals. The core of the nanocrystal is composed of an electroactive oxide, which is passivated by an ultrathin epitaxial oxide shell enriched in a redox inactive ion. This approach imparts interfacial stability while preserving the high storage capability and fast carrier transport of the material, compared to unmodified versions. The validity of the concept is proved with Li1+xMn2–xO4 nanocrystals with a 1–2 nm Al-rich shell, which showed reduced sensitivity to harsh environments, compared to bare counterparts. The approach is generalizable to any transition-metal-based battery system where electrode–electrolyte interactions must be controlled.
Towards a view invariant gait recognition algorithm (2004)

Human gait is a spatio-temporal phenomenon and typifies the motion characteristics of an individual. The gait of a person is easily recognizable when extracted from a side-view of the person. Accordingly, gait-recognition algorithms work best when presented with images where the person walks parallel to the camera image plane. However, it is not realistic to expect this assumption to be valid in most real-life scenarios. Hence, it is important to develop methods whereby the side-view can be generated from any other arbitrary view in a simple, yet accurate, manner. This is the main theme of the paper. We show that if the person is far enough from the camera, it is possible to synthesize a side view (referred to as canonical view) from any other arbitrary view using a single camera. Two methods are proposed for doing this: (i) using the perspective projection model; (ii) using the optical flow based structure from motion equations. A simple camera calibration scheme for this method is also proposed. Examples of synthesized views are presented. Preliminary testing with gait recognition algorithms gives encouraging results. A by-product of this method is a simple algorithm for synthesizing novel views of a planar scene.
Artificial uniaxial and biaxial dielectrics with use of two-dimensional subwavelength binary gratings (1994)

Two-dimensional symmetric and asymmetric subwavelength binary gratings are investigated. A method for determining the three effective indices of a two-dimensional (2-D) subwavelength grating is presented, as well as a theoretical formalization for the effective index parallel with the normal to the surface. It is shown that a 2-D asymmetric binary grating on the surface of a dielectric substrate is analogous to a biaxial thin film. If the grating is symmetric, then the two effective indices perpendicular to the normal are equal, and the grating is analogous to a uniaxial thin film. Using these effective indices and the quarter-wave Tschebyscheff synthesis technique, we designed two- and three-level binary gratings to suppress reflections over a broad band. It is shown that for a substrate index of ns = 3.0 a three-level 2-D binary grating reduced reflections below 0.1% from 8 μm to 12 μm.
Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma (2010)

Regulatory T cells in the tumor microenvironment may abrogate CD8(+) T cell cytotoxicity in a granzyme B- and perforin-dependent conduit. Decreases in both Th1 cytokines and cytotoxic enzymes are relevant for regulatory T cell-mediated restraint of tumor clearance in vivo. Of clinical significance, the expression of regulatory T cells in TILs may mediate T cell immune repression within cancer milieu and thus greatly correlate with cancer progression.
Development and Performance Analysis of the Phocus C-Module (2008)

The Photovoltaic Concentrator technology is considered a promising alternative option to PV-flat to overcome the present day barriers in terms of material shortage and costs. Relevance was given by ENEA through the PhoCUS project having the aim to develop a new technology able to realize a monolytic low-cost photovoltaic module suitable to work under medium concentration (200X). Several technical problems were faced and overcome about the development of the solar cells, the system housing integrating optics and receivers, the realization of the lenses and heat spreaders and the mechanical-thermal and electrical performance modelling. In order to meet the low cost requirement a large use of conventional materials and components together with manufacturing and assembling techniques addressed to a cheap full automation have been adopted in cooperation with national industrial operators. The effort made has brought to file many patents relating novel solutions used in Phocus C-module. The final product meeting the design specification was obtained.
Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension (2006)

Severe pulmonary hypertension (SPH) is characterized by precapillary arteriolar lumen obliteration, dramatic right ventricular hypertrophy, and pericardial effusion. Our recently published rat model of SPH recapitulates major components of the human disease. We used this model to develop new treatment strategies for SPH. SPH in rats was induced using VEGF receptor blockade in combination with chronic hypoxia. A large variety of drugs used in this study, including anticancer drugs (cyclophosphamide and paclitaxel), the angiotensin-converting enzyme inhibitor lisinopril, the antiangiogenic agent thalidomide, and the peroxisome proliferator-actived receptor-gamma agonist PGJ2, failed to decrease mean pulmonary artery pressure (PAP) or right ventricular hypertrophy. In contrast, treatment of rats with established SPH with simvastatin markedly reduced mean PAP and right ventricular hypertrophy, and this reduction was associated with caspase-3 activation and pulmonary microvascular endothelial cell apoptosis. Simvastatin partially restored caveolin-1, caveolin-2, and phospho-caveolin expression in vessel walls. In rat primary pulmonary microvascular endothelial cells, simvastatin induced caspase 3 activation and Rac 1 expression while suppressing Rho A and attenuated levels of Akt and ERK phosphorylation. We conclude that simvastatin is effective in inducing apoptosis in hyperproliferative pulmonary vascular lesions and could be considered as a potential drug for treatment of human SPH.
Solar Position Algorithm for Solar Radiation Applications (Revised) (2007)

This report is a step-by-step procedure for implementing an algorithm to calculate the solar zenith and azimuth angles in the period from the year -2000 to 6000, with uncertainties of ?0.0003/. It is written in a step-by-step format to simplify otherwise complicated steps, with a focus on the sun instead of the planets and stars in general. The algorithm is written in such a way to accommodate solar radiation applications.
Effects of Mutations in Ribosomal Protein L16 on Susceptibility and Accumulation of Evernimicin (2001)

Chemical mutagenesis of Staphylococcus aureus RN450 generated two strains that displayed a stable reduction (30- to 60-fold) in susceptibility to evernimicin. Cell-free translation reactions demonstrated that the resistance determinant was located in the ribosomal fraction. Compared to ribosomes isolated from a wild-type strain, ribosomes from the mutant strains displayed an 8- to 10-fold reduction in affinity for [(14)C]evernimicin. In contrast, the mutants displayed no alteration in either binding affinity or in vitro susceptibility to erythromycin. Exponential cultures of the mutant strains accumulated significantly less [(14)C]evernimicin than the wild-type strain, suggesting that accumulation is dependent on the high affinity that evernimicin displays for its binding site. Sequencing rplP (encodes ribosomal protein L16) in the mutant strains revealed a single base change in each strain, which resulted in a substitution of either cysteine or histidine for arginine at residue 51. Introduction of a multicopy plasmid carrying wild-type rplP into the mutant strains restored sensitivity to evernimicin, confirming that the alterations in rplP were responsible for the change in susceptibility. Overexpression of the mutant alleles in S. aureus RN450 had no effect on susceptibility to evernimicin, demonstrating that susceptibility is dominant over resistance.
Quinazolines as Apoptosis Inducers and Inhibitors: A Review of Patent Literature (2015)

Quinazoline scaffold has been successfully utilized for development of various inhibitors of tubulin, epidermal growth factor receptor (EGFR), polo like kinases (PLKs), Hedgehog-Gli signaling pathway and protein kinase B (PKB) /Akt pathway. Compounds based on quinazolines have shown efficacies in µM to nM range in various cancer cell lines and thus could be useful scaffolds for development of both apoptosis inducers as well as inhibitors. This compilation is based on various patents published till 2015 and divides the quinazolines in two main categories: Quinazolines as apoptosis inducers and as apoptosis inhibitors. These two main categories are further sub-categorized based on the use/pharmacological indications for these classes of patented compounds. This review will act as a tool for the researchers working on exploring the anticancer potential of quinazoline as a privileged heterocyclic. The promising anticancer profile of some of the quinazoline based compounds clearly highlights the clinical potential of this heterocycle.
High mobility OFDM transmission system by a new channel estimation and ISI cancellation scheme using characteristics of pilot symbol inserted OFDM signal (1999)

The OFDM transmission system can effectively reduce intersymbol interference caused by multipath fading, especially in the case of broadband data transmission. Nevertheless, the delayed waves existing in a symbol degrade the transmission performance at the receiver. Therefore when the OFDM transmission system applies to a mobile radio communication system, we have to remove the influence without intricacy. This paper proposes a new scheme in order to estimate the propagation characteristics using the characteristics of the distinctive OFDM signal which is a periodically inserted pilot signal in the frequency axis before IFFT at the transmitter. Moreover, we introduce a cancellation scheme of delayed waves on the basis of the proposed estimation technique. Using these schemes, it is possible to estimate and cancel the interference of the delayed wave before FFT at the receiver. In this paper, moreover, we evaluate the estimation accuracy of the proposed estimation method and the BER performance of the proposed system under fast multipath fading environment by computer simulation. Especially, in this simulation, we utilize the evaluation format of OFDM discussed in the Multimedia Mobile Access Communication Systems Promotion Council (MMAC).
The assessment of physical activity in individuals and populations: why try to be more precise about how physical activity is assessed? (1998)

Simple epidemiological measures of physical activity have proved sufficient to demonstrate associations with many chronic disease outcomes, but they have infrequently separated physical activity into its different dimensions, nor have they allowed estimation of dose-response effects. Generating greater clarity about the nature of the exposure-disease relationship, is an important step in the development of an appropriate public health intervention. This clarity can only be achieved with reliable and valid measurement instruments, which objectively and quantitatively assess the dimension of physical activity that is of interest for a particular health outcome. Objective techniques, such as heart rate monitoring, which have been directly compared to gold standard assessment methods, may be of use in medium-sized epidemiological studies and as a validation tool for questionnaires to be used in larger studies. The combination of methods with uncorrelated error, would result in an improved estimation of the true exposure and is an important area for research. Improved assessment would be of use in aetiological studies, in tracking trends in physical activity within populations, making objective comparisons between populations and in monitoring the effect of interventions.
The Roles of Phytochromes in Elongation and Gravitropism of Roots (2005)

Gravitropic orientation and the elongation of etiolated hypocotyls are both regulated by red light through the phytochrome family of photoreceptors. The importance of phytochromes A and B (phyA and phyB) in these red light responses has been established through studies using phy mutants. To identify the roles that phytochromes play in gravitropism and elongation of roots, we studied the effects of red light on root elongation and then compared the gravitropic curvature from roots of phytochrome mutants of Arabidopsis (phyA, phyB, phyD and phyAB) with wild type. We found that red light inhibits root elongation approximately 35% in etiolated seedlings and that this response is controlled by phytochromes. Roots from dark- and light-grown double mutants (phyAB) and light-grown phyB seedlings have reduced elongation rates compared with wild type. In addition, roots from these seedlings (dark/light-grown phyAB and light-grown phyB) have reduced rates of gravitropic curvature compared with wild type. These results demonstrate roles for phytochromes in regulating both the elongation and gravitropic curvature of roots.
A simplified paired neck chamber for the demonstration of baroreflex blood pressure regulation. (1999)

In this investigation a simplified variable-pressure paired neck chamber was developed as a practical alternative to traditional neck collar designs used to study the arterial baroreceptor reflex in humans. The purpose of this new design was to extend the use of the noninvasive neck chamber method of baroreceptor investigation to teachers of physiology. Performance tests indicate that these new chambers are capable of delineating the stimulus-response relationship for both the blood pressure baroreflex [sensitivity = 0.425 +/- 0.13 mmHg mean arterial pressure (MAP)/mmHg neck chamber pressure (NCP); range = 24.9 +/- 4.6 mmHg MAP] and the heart rate baroreflex (sensitivity 0.273 +/- 0.12 beats.min-1.mmHg NCP-1; range = 16.7 +/- 6.8 beats/min). This was achieved by applying localized positive and negative air pressures to the carotid sinuses throughout the range from +60 to -60 mmHg in steps of 20 mmHg. This simplified neck chamber method offers distinct methodological advantages over traditional neck collars, making it a valuable tool for demonstrating baroreflex regulation of the circulation.
The entire nucleotide sequences of three hepatitis C virus isolates in genetic groups 7-9 and comparison with those in the other eight genetic groups. (1998)

We have proposed that hepatitis C virus should be classified into eleven genetic groups (types) which further divide into more than 80 genotypes (subtypes). However, only eight genetic groups (1-6, 10 and 11) have been defined on the basis of the full-length sequence. Hence, the entire nucleotide sequences of three HCV isolates in genetic groups 7-9 have now been determined. Phylogenetic analysis over the full-length sequences of these three isolates, along with 30 more in the other eight genetic groups, indicated that genetic groups 6-9 and 11 have bifurcated from a common branch and groups 3 and 10 from another. In the former branch groups 7 and 11, and groups 8 and 9, are closely related. Consequently, HCV can be classified into either eleven (1-11) or six groups (1; 2; 3 and 10; 4; 5; 6-9 and 11), allowing a clear separation of group and genotype similarity within the NS5b region or a subregion of 1093 nt. When pairwise comparison of 1093 nt in the NS5b sequence was performed on 106 HCV isolates of 36 genotypes in eleven genetic groups, they were classified into either eleven (1-11) or six (1; 2; 3 and 10; 4; 5; 6-9 and 11) genetic groups. However, group and genotype similarities were not clearly separable in either classification. The overlapping range was smaller using the classification into eleven genetic groups as compared to six genetic groups (2.7 vs 4-7%). These results indicate that HCV might not have evolved in the two-tiered fashion, at least in a strict sense.
The Genetics of Corn (1988)

Studies in corn have identified genetic variation attributable to unitary factors at perhaps 1000 or more loci, loosely defined; if rigorous criteria were applied with regard to supporting data, tests for allelism, and pleiotropisms, perhaps 575 loci could be documented unequivocally. Because of losses of strains, pending work, and preliminary reports in the MNL that have not been carried further, it has not been possible to include some factors. Aids to systematic description and cataloguing of genetic variation include the nomenclatural conventions, listings of the known factors, and linkage maps. The chapter considers dosage effects and codominance; duplicate factors; cell autonomy and auxotrophy; sporophyte-determined traits, induction and imprinting; and pleiotropisms. Much genetic information is available on unit factors controlling characteristics that are directly visible, especially in the kernel and the plant body: form, color, size and developmental progression.
Epigenetic Silencing Mediated through Activated PI3K/AKT Signaling in Breast Cancer (2011)

Trimethylation of histone 3 lysine 27 (H3K27me3) is a critical epigenetic mark for the maintenance of gene silencing. Additional accumulation of DNA methylation in target loci is thought to cooperatively support this epigenetic silencing during tumorigenesis. However, molecular mechanisms underlying the complex interplay between the two marks remain to be explored. Here we show that activation of PI3K/AKT signaling can be a trigger of this epigenetic processing at many downstream target genes. We also find that DNA methylation can be acquired at the same loci in cancer cells, thereby reinforcing permanent repression in those losing the H3K27me3 mark. Because of a link between PI3K/AKT signaling and epigenetic alterations, we conducted epigenetic therapies in conjunction with the signaling-targeted treatment. These combined treatments synergistically relieve gene silencing and suppress cancer cell growth in vitro and in xenografts. The new finding has important implications for improving targeted cancer therapies in the future.
Investigation of a Miniaturized Capillary Isoelectric Focusing (cIEF) System Using a Full-Field Detection Approach (2000)

Sample handling in miniaturized bioanalytical instruments typically depends on pressure or electrokinetic effects. This is particularly true of post-separation detection processes where a sample is moved past a single point detector. In contrast to such methods, the present study investigates a separation system that takes advantage of a steady-state, stationary separation technique known on the macroscale as capillary isoelectric focusing (cIEF). Due to the stationary nature of the final separation, sample analysis is conducted entirely without mobilization.
Endo-Selective Enyne Ring-Closing Metathesis Promoted by Stereogenic-at-W Mono-Pyrrolide Complexes (2011)

The utility of W-alkylidene complexes for enyne ring-closing metathesis is demonstrated in a direct comparison with Mo-based analogs. Tungsten complexes lead to less alkyne oligomerization and higher levels of endo-selectivity and enantioselectivity.
Singlet Oxygen Generation from Water-Soluble Quantum Dot−Organic Dye Nanocomposites (2006)

Water-soluble quantum dot-organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanethiol as a stabilizer, and meso-tetra(4-sulfonatophenyl)porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum dot is largely suppressed. Instead, indirect excitation of the TSPP moiety leads to production of singlet oxygen with a quantum yield of 0.43. The nanocomposite is sufficiently photostable for biological applications.
Applying Multi-Agent Techniques to Cancer Modeling (2013)

Each year, cancer is responsible for 13 % of all deaths worldwide. In the United States, that percentage increases to 25%, translating to an estimated 569,490 deaths in 2010 [1]. Despite significant advances in the fight against cancer, these statistics make clear the need for additional research into new treatments. As such, there has been growing interest in the use of computer simulations as a tool to aid cancer researchers. We propose an innovative multi-agent approach in which healthy cells and cancerous cells are modeled as opposing teams of agents using a decentralized Markov decision process (DEC-MDP). We then describe changes made to traditional DEC-MDP algorithms in order to better handle the complexity and scale of our domain. We conclude by presenting and analyzing preliminary simulation results. This paper is intended to introduce the cancer modeling domain to the multi-agent community with the hope of fostering a discussion about the opportunities and challenges it presents. Given the complexity of the domain, we do not claim our approach to be a definitive solution but rather a first step toward the larger goal of creating realistic simulations of cancer.
Gene therapy approaches to HIV-infection : immunological strategies : use of T bodies and universal receptors to redirect cytolytic T-cells (1999)

Combined regimens of classical antiviral treatments have not, until now, lead to the eradication of HIV-1. A specific anti-HIV immune response may have to be boosted or transferred to patients after suppression of viral replication, in order to eradicate residual infected cells from their sanctuaries. Cytotoxic T cells engineered to express recombinant chimeric receptors can be redirected against HIV-infected cells and could represent the basis of a new type of immunotherapy. Several HIV epitopes have been targeted successfully in vitro. Two types of binding domains (antibody fragments, CD4) fused with various signal transducing units (zeta chain of the CD3 complex, Fc epsilon RI gamma chain) have been tested for their ability to redirect effector cells to HIV infected lymphocytes. CD4-zeta-expressing myeloid and natural killer cells conferred SCID mice protection against challenge with tumor cells expressing HIV-env. Finally, the safety of the adoptive transfer of syngeneic CD4-zeta -modified T cells in HIV-infected individuals is currently under evaluation.
InP-based comb generator for optical OFDM (2011)

We propose a new InP-based comb generator for optical OFDM transmission. The device integrates a Mach-Zehnder modulator inside an amplified ring. We demonstrate a 6-line frequency comb which is tunable in wavelength and spacing.