gebhart/patrepeval huggingface dataset:
Handbook of plastic optics (2005)

List of Contributors. 1 Introduction. 2 Optomechanics of Plastic Optical Components. 2.1 Introduction. 2.2 Configuration of Plastic Optical Elements. 2.3 Mounting Plastic Optical Elements. 2.4 Dimensional Stability. 2.5 Tolerancing. 2.6 Optomechanical Simulation of Plastic Optical Elements. 3 Tooling for Injection Molded Optics. 3.1 Introduction. 3.2 Principles. 3.3 Molding Variations. 3.4 Optical Mold Inserts. 3.5 Ultra-precision Machine Tools for Mold-Making. 4 Metrologyof Injection Molded Optics. 4.1 Introduction. 4.2 Dimensional Metrology. 4.3 Optical Metrology. 4.4 Tactile Profiling. 4.5 Centration Measurement. 4.6 Birefringence. 4.7 Custom Setups. 4.8 Concluding Remarks. 5 Optical Plastics. 5.1 Introduction. 5.2 Quality Requirements for Optical Plastics. 5.3 Plastics. 5.4 Summary. 6 Coating on Plastics. 6.1 Introduction. 6.2 Deposition Techniques. 6.3 Plasma Effects on Polymers. 6.4 Stresses and Crack Formation. 6.5 Test and Qualification Methods. 6.6 Antireflective Properties. 6.7 Additional Functional Coatings. 6.8 Coating with Different Thermoplastics. 6.9 Summary and Outlook. Index.
Role of Ethylene Oxide and Propylene Oxide Groups of Pluronics in Binding of Fatty Acid to Pluronics in Microemulsions (2008)

Abstract We investigated the drug and fatty acid binding capacity of Pluronic‐based microemulsions through simple turbidity experiments. Pluronic‐based oil‐in‐water microemulsions of various compositions were synthesized and titrated to turbidity with concentrated amitriptyline, an antidepressant drug. The BASF Pluronic grid was used to select two series of Pluronic surfactants: (1) those having the same number of ethylene oxide (EO) groups, with an increasing number of propylene oxide (PO) groups and (2) those having the same number of propylene oxide groups with an increasing number of ethylene oxide groups. We observed that the binding of sodium caprylate fatty acid and amitriptyline drug increases with increasing hydrophobicity (i.e., increasing number of PO groups). This is attributed to the greater number of binding sites for the sodium caprylate, which results in more charge on the microemulsion, subsequently leading to increased drug binding. We also determined that when the number of PO groups was held fixed and the number of EO groups was increased, there is no direct correlation to the binding behavior of fatty acid and drug. This is due to the fact that the hydrophilic groups (EO) do not play a direct role in the binding of fatty acid molecules. In fact, when there are a significantly large number of EO groups present, they can act to inhibit binding of fatty acid and hence, drug, to the microemulsion.
Mesostructured multifunctional nanoparticles for imaging and drug delivery (2009)

Mesostructured silica particles (∼100 nm diameter with ∼2 nm pores) prepared by surfactant-templated sol–gel techniques are versatile supports that can be easily derivatized with active molecules to create multifunctional materials. By deliberately placing active molecules in different regions of the mesostructure, fluorescent molecules, molecular machines, targeting ligands, and metal nanocrystals can be combined on a single particle. This review highlights the research in which multiple components are incorporated onto mesoporous silica for simultaneous imaging and delivery of molecules in biological applications.
Guanidinium Rich Peptide Transporters and Drug Delivery (2003)

The use of peptide or peptidomimetic transporters to enable or enhance the uptake of drugs or probe molecules into cells and tissues has received increasing research attention and clinical interest over the past 10 years. This review summarizes a class of transporters that have been studied and focuses on the variation and use of guanidinium based transporters to facilitate the uptake of various types of molecules into cells and tissues. Lead conjugates in this area are currently in clinical trials.
Cadmium Increases GLUT1 Substrate Binding Affinity in Vitro While Reducing Its Cytochalasin B Binding Affinity (1996)

Cadmium stimulates glucose transport in fibroblasts, apparently by increasing the intrinsic activity of GLUT1 [Harrison, S.A., Buxton, J.M., Clancy, B.M., & Czech, M.P. (1991) J. Biol. Chem. 266, 19438-19449]. In the present study, we examined whether cadmium affects the binding in vitro of purified GLUT1 to glucose and cytochalasin B. Cadmium inhibited cytochalasin B binding to GLUT1 competitively by reducing its binding affinity with an apparent inhibition constant of approximately 0.2 mM. However, D-glucose displaced cytochalasin B bound to GLUT1 as effectively in the presence of cadmium as in its absence, and detailed analysis of this displacement revealed that cadmium in fact increases the substrate binding affinity significantly. These findings suggest that cadmium induces a specific conformational change in GLUT1 that interferes with cytochalasin B binding but enhances substrate binding. This is the first clear demonstration in which the substrate and cytochalasin B binding activities of GLUT1 are differentially affected, which may offer insight into the workings of the glucose transporter.
DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA (2001)

We show that DNA molecules amplified by PCR from DNA extracted from animal bones and teeth that vary in age between 25 000 and over 50 000 years carry C-->T and G-->A substitutions. These substitutions can reach high proportions among the molecules amplified and are due to the occurrence of modified deoxycytidine residues in the template DNA. If the template DNA is treated with uracil N-glycosylase, these substitutions are dramatically reduced. They are thus likely to result from deamination of deoxycytidine residues. In addition, 'jumping PCR', i.e. the occurrence of template switching during PCR, may contribute to these substitutions. When DNA sequences are amplified from ancient DNA extracts where few template molecules initiate the PCR, precautions such as DNA sequence determination of multiple clones derived from more than one independent amplification are necessary in order to reduce the risk of determination of incorrect DNA sequences. When such precautionary measures are taken, errors induced by damage to the DNA template are unlikely to be more frequent than approximately 0.1% even under the unlikely scenario where each amplification starts from a single template molecule.
Epidermal Growth Factor Receptor Dynamics Influences Response to Epidermal Growth Factor Receptor Targeted Agents (2005)

Analysis of gene expression of cancer cell lines exposed to erlotinib, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), showed a marked increase in EGFR mRNA in resistant cell lines but not in susceptible ones. Because cetuximab induces EGFR down-regulation, we explored the hypothesis that treatment with cetuximab would interfere with erlotinib-induced EGFR up-regulation and result in antitumor effects. Exposure of the resistant biliary tract cancer cell line HuCCT1 but not the susceptible A431 epidermoid cell line to erlotinib induced EGFR mRNA and protein expression. Combined treatment with cetuximab blunted the erlotinib-induced EGFR up-regulation and resulted in inhibition of cell proliferation and apoptosis in the HuCCT1 cells. Blockage of erlotinib-induced EGFR synthesis in HuCCT1 cells by small interfering RNA resulted in identical antitumor effects as cetuximab, providing mechanistic specificity. In mice xenografted with A431, HuCCT1, and the pancreatic cancer cell line Panc430, maximal growth arrest and decrease in Ki67 proliferation index were documented with combined therapy, and EGFR down-regulation was observed in cetuximab-treated tumors. These results may indicate that resistance to EGFR kinase inhibition may be, at least in part, mediated by a highly dynamic feedback loop consisting of up-regulation of the EGFR upon exposure to EGFR kinase inhibitors. Abrogation of this response by small interfering RNA-mediated EGFR mRNA down-regulation and/or by cetuximab-mediated protein clearance induced tumor arrest across several cancer models with different EGFR expression levels, suggesting that resistance and sensitivity are dynamic events where proportional decrease in the target rather than absolute content dictates outcome.
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. (1987)

Cell lines have been established that secrete a matched set of human chimeric IgM, IgG1, IgG2, IgG3, IgG4, IgE, and IgA2 antibodies that are directed against the hapten 4-hydroxy-3-nitrophenacetyl. These chimeric antibodies secreted from mouse plasmacytoma cells behave exactly like their authentic human counterparts in SDS-PAGE analysis, binding to protein A and in a wide range of serological assays. The antibodies have been compared in their ability to bind human C1q as well as in their efficacy in mediating lysis of human erythrocytes in the presence of human complement. A major conclusion to emerge is that whereas IgG3 bound C1q better than did IgG1, the chimeric IgG1 was much more effective than all the other IgG subclasses in complement-dependent hemolysis. The IgG1 antibody was also the most effective in mediating antibody-dependent cell-mediated cytotoxicity using both human effector and human target cells. These results suggest that IgG1 might be the favoured IgG subclass for therapeutic applications.
Electrocatalytic Hydrogenation of 5‐Hydroxymethylfurfural in the Absence and Presence of Glucose (2013)

Electrocatalytic hydrogenation of 5-hydroxymethylfurfural (HMF) to 2,5-dihydroxymethylfuran (DHMF) or other species, such as 2,5-dimethylfuran, on solid metal electrodes in neutral media is addressed, both in the absence and in the presence of glucose. The reaction is studied by combining voltammetry with on-line product analysis by using HPLC, which provides both qualitative and quantitative information about the reaction products as a function of electrode potential. Three groups of catalysts show different selectivity towards: (1) DHMF (Fe, Ni, Ag, Zn, Cd, and In), (2) DHMF and other products (Pd, Al, Bi, and Pb), depending on the applied potential, and (3) other products (Co, Au, Cu, Sn, and Sb) through HMF hydrogenolysis. The rate of electrocatalytic HMF hydrogenation is not strongly catalyst-dependent because all catalysts show similar onset potentials (-0.5 ± 0.2 V) in the presence of HMF. However, the intrinsic properties of the catalysts determine the reaction pathway towards DHMF or other products. Ag showed the highest activity towards DHMF formation (up to 13.1 mM cm(-2) with high selectivity> 85%). HMF hydrogenation is faster than glucose hydrogenation on all metals. For transition metals, the presence of glucose enhances the formation of DHMF and suppresses the hydrogenolysis of HMF. On poor metals such as Zn, Cd, and In, glucose enhances DHMF formation; however, its contribution in the presence of Bi, Pb, Sn, and Sb is limited. Remarkably, in the presence of HMF, glucose hydrogenation itself is largely suppressed or even absent. The first electron-transfer step during HMF reduction is not metal-dependent, suggesting a non-catalytic reaction with proton transfer directly from water in the electrolyte.
Current issues in Sjögren's syndrome (2002)

Sjögren's syndrome is a chronic autoimmune and rheumatic disorder with prominent sicca complaints from the mucous membranes because of lack of proper exocrine secretions. There is no straightforward and simple diagnostic test for Sjögren's syndrome, although several classification criteria have been designed including several oral diagnostic tests. A new set of classification criteria in a joint effort by research groups in Europe and USA has recently been presented. A large number of autoantibodies have been reported in Sjögren's syndrome where, in some cases, the antibodies are correlated with the extent and severity of disease. The finding of serum autoantibodies directed against the muscarinic M3 receptor is an important advance in understanding the pathogenesis of not only the impaired glandular function but also associated features of autonomic dysfunction in some patients. The treatment of primary Sjögren's syndrome is still mainly symptomatic.
Laccase‐catalyzed Synthesis and Antioxidant Property of Poly(catechin) (2003)

Abstract Catechin was oxidatively polymerized by laccase in a mixture of a polar organic solvent and buffer to give a new class of flavonoid polymers. Myceliophthora laccase showed high catalytic activity for the polymerization. Using a mixed solvent of acetone and pH 5 acetate buffer efficiently produced the polymer. Under the selected conditions, DMF‐soluble polymers were obtained in good yields. Effects of reaction parameters on the yield, solubility, and molecular weight of the polymer have been systematically investigated. A radical species was detected in the polymer by ESR spectroscopy. The polymers showed greatly amplified superoxide scavenging activity and xanthine oxidase inhibitory activity compared with monomeric catechin. Superoxide scavenging activity of poly(catechin)s, n = 3. ○: catechin, □: poly(catechin). magnified image Superoxide scavenging activity of poly(catechin)s, n = 3. ○: catechin, □: poly(catechin).
Inhibition of Allergic Reactions with Antibodies to IgE (1995)

Numerous clinical studies show that direct interference with the IgE response leads to a decrease or elimination of allergic symptoms. The aim of these studies was to design a therapy aimed at decreasing IgE levels in order to ameliorate atopic disease. To this end, a murine monoclonal antibody, MAE11, directed against IgE was identified, which had all the properties necessary to interfere with IgE responses, but lacked the harmful side effects of inducing receptor cross-linking. The antibody was selected on the basis of its ability to bind circulating IgE at the same site as the high-affinity receptor, thus blocking the binding of IgE to mast cells and basophils. To allow for possible chronic administration and to avoid the problems of antigenicity, MAE11 was humanized. The best of several humanized variants, version 25 (rhumAb-E25) was selected since it possessed binding affinity and biological activity comparable to MAE11. Clinical studies are underway to determine the safety and efficacy of this treatment for allergic rhinitis and asthma.
Aberrant CpG island hypermethylation of multiple genes in prostate cancer and prostatic intraepithelial neoplasia (2004)

To date, several reports have been published about CpG island methylation of various genes in prostate cancer. However, most of these studies have focused on cancer tissue only or a single gene and data about concurrent methylation of multiple genes in prostate cancer or prostatic intraepithelial neoplasia (PIN) are limited. The aim of the present study was to determine the methylation profile of 11 tumour-related genes in prostate cancer and PIN. Seventy-one samples, including 37 prostate cancers, 14 PINs, and 20 normal prostates, were examined for the methylation status of 11 tumour-related genes using methylation-specific PCR. The mean number of genes methylated was significantly higher in prostate cancer and PIN than in non-neoplastic prostate (4.4, 3, and 0.2, respectively; p < 0.001). In prostate cancer, APC, GSTP1, MGMT, and RASSF1A were frequently methylated at a frequency of 56.8%, 86.5%, 75.7%, and 83.8%, respectively. These genes were methylated in more than 30% of PINs. Prostate cancers with high serum prostate-specific antigen (PSA) (more than 8 ng/ml) or a high Gleason score (GS) (3 + 4 or more) showed higher numbers of methylated genes than those with low serum PSA (8 or less) or low GS (3 + 3 or less) (5.4 versus 2.5 and 5.4 versus 3.1, respectively; p < 0.05). The methylation frequency of APC, RASSF1A, and RUNX3 was higher in prostate cancers with high serum PSA or with high GS than in those with low PSA or with low GS, respectively, the differences reaching statistical significance (p < 0.05). A strong association between MGMT methylation and loss of MGMT expression was demonstrated by immunohistochemistry. CpG island methylation is a frequent event, occurs early, and accumulates during multi-step prostatic carcinogenesis. High levels of CpG island hypermethylation might serve as a potential biological marker for aggressive prostate cancer.
DNA sequence of the araBAD promoter in Escherichia coli B/r. (1978)

The L-arabinose operon in Escherichia coli is a model system for the study of the control of gene expression. Maximal expression of the araBAD operon requires two positive control components: the araC protein-L-arabinose complex and the cyclic AMP receptor protein-cyclic AMP complex. Both araC protein and cyclic AMP receptor protein are required for the initiation of transcription of araBAD mRNA. We have used the plasmid pBR322 as a vector for cloning DNA fragments that contain the araBAD promoter. The cloned ara fragments were identified by both physical and genetic tests. A restriction map was constructed and the DNA sequence of the promoter was determined. The promoter contains a site that is similar to the RNA polymerase recognition sites in the galactose and lactose operons. It also contains a region similar to the known cyclic AMP receptor protein binding sites in the galactose and lactose operons.
Novel Nanostructures of Functional Oxides Synthesized by Thermal Evaporation (2003)

Abstract Functional oxides are the fundamentals of smart devices. This article reviews novel nanostructures of functional oxides, including nanobelts, nanowires, nanosheets, and nanodiskettes, that have been synthesized in the authors’ laboratory. Among the group of ZnO, SnO 2 , In 2 O 3 , Ga 2 O 3 , CdO, and PbO 2 , which belong to different crystallographic systems and structures, a generic nanobelt structure has been synthesized. The nanobelts are single crystalline and dislocation‐free, and their surfaces are atomically flat. The oxides are semiconductors, and have been used for fabrication of nanodevices such as field‐effect transistors and gas sensors. Taking SnO 2 and SnO as examples, other types of novel nanostructures are illustrated. Their growth, phase transformation, and stability are discussed. The nanobelts and related nanostructures are a unique group that is likely to have important applications in electronic, optical, sensor, and optoelectronic nanodevices.
A Tour of Modern Image Filtering: New Insights and Methods, Both Practical and Theoretical (2012)

In this article, the author presents a practical and accessible framework to understand some of the basic underpinnings of these methods, with the intention of leading the reader to a broad understanding of how they interrelate. The author also illustrates connections between these techniques and more classical (empirical) Bayesian approaches. The proposed framework is used to arrive at new insights and methods, both practical and theoretical. In particular, several novel optimality properties of algorithms in wide use such as block-matching and three-dimensional (3-D) filtering (BM3D), and methods for their iterative improvement (or nonexistence thereof) are discussed. A general approach is laid out to enable the performance analysis and subsequent improvement of many existing filtering algorithms. While much of the material discussed is applicable to the wider class of linear degradation models beyond noise (e.g., blur,) to keep matters focused, we consider the problem of denoising here.
Biology and applications of Mesenchymal Stem Cells (2010)

Undifferentiated adult stem cells are responsible for cell replacement in adult organisms. Initially isolated from the bone marrow, they are now known to be distributed throughout the organism as a whole, with a perivascular location. They are defined by properties which include proliferation as adherent cells, a defined immunophenotype, and the capacity to differentiate in vitro into osteoblasts, adipocytes and chondroblasts. Mesenchymal stem cells (MSCs) are considered as one of the most promising cell types for therapeutic applications. Mechanisms responsible for this therapeutic role are not well understood, and may involve diferentiation or, as most evidences point out, paracrine activity. The ability to modulate the immune system opens a wide range of applications, mainly for autoimmune diseases and graft-versus-host disease. Preclinical and clinical studies show promising results, but controversial results are still reported, indicating the need for further basic and preclinical investigation on their therapeutic potential. This review will focus on recent advances in understanding MSC biology and applications in cell therapy.
Wettability Alteration in High-Temperature and High-Salinity Carbonate Reservoirs (2013)

Summary The goal of this work was to change the wettability of a carbonate rock from mixed-wet toward water-wet at high temperature and high salinity. Three types of surfactants in dilute concentrations (&amp;lt;0.2 wt%) were used. Initial surfactant screening was performed on the basis of aqueous stability at these harsh conditions. Contact-angle experiments on aged calcite plates were conducted to narrow the list of surfactants, and spontaneous-imbibition experiments were conducted on field cores for promising surfactants. Secondary waterflooding was carried out in cores with and without the wettability-altering surfactants. It was observed that most but not all surfactants were aqueous-unstable by themselves at these harsh conditions. Dual-surfactant systems, mixtures of a nonionic and a cationic surfactant, increased the aqueous stability. Some of the dual-surfactant systems proved effective for wettability alteration and could recover could recover 70 to 80% OOIP (original oil in place) during spontaneous imbibition. Secondary waterflooding with the wettability-altering surfactant increased the oil recovery over the waterflooding without the surfactants (from 29 to 40% of OOIP).
Changes in nitrate and nitrite content, and search for nitrosamines in storage-abused spinach and beets (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChanges in nitrate and nitrite content, and search for nitrosamines in storage-abused spinach and beetsEdward G. Heisler, James. Siciliano, Samuel. Krulick, Jules. Feinberg, and Joseph H. SchwartzCite this: J. Agric. Food Chem. 1974, 22, 6, 1029–1032Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/jf60196a012https://doi.org/10.1021/jf60196a012research-articleACS PublicationsRequest reuse permissionsArticle Views281Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts