gebhart/patrepeval huggingface dataset:
Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. (1997)

Vascular endothelial growth factor (VEGF) is an angiogenic polypeptide that has been implicated in cancer growth. In the present study, we characterized VEGF expression in cultured human pancreatic cancer cell lines and determined whether the presence VEGF in human pancreatic cancers is associated with enhanced neovascularization or altered clinicopathological characteristics. VEGF mRNA transcripts were present in all six tested cell lines (ASPC-1, CAPAN-1, MIA-PaCa-2, PANC-1, COLO-357, and T3M4). Immunoblotting with a highly specific anti-VEGF antibody revealed the presence of VEGF protein in all of the cell lines. Northern blot analysis of total RNA revealed a 5.2-fold increase in VEGF mRNA transcript in the cancer samples in comparison with the normal pancreas. Immunohistochemical and in situ hybridization analysis confirmed the expression of VEGF in the cancer cells within the tumor mass. Immunohistochemical analysis of 75 pancreatic cancer tissues revealed the presence of strong VEGF immunoreactivity in the cancer cells in 64% of the cancer tissues. The presence of VEGF in these cells was associated with increased blood vessel number, larger tumor size, and enhanced local spread but not with decreased patient survival. These findings indicate that VEGF is commonly overexpressed in human pancreatic cancers and that this factor may contribute to the angiogenic process and tumor growth in this disorder.
Immunological castration using a gonadotrophin‐releasing hormone analogue conjugated to PPD (1995)

Abstract The importance of gonadotrophin‐releasing hormone/luteinizing hormone‐releasing hormone (GnRH/LHRH) to reproductive function is illustrated when animals immunized with GnRH produce a high humoral immune response which can achieve a humane alternative to surgical castration. In this paper, the male rat was used as a model. Rats were immunized with an analogue of GnRH—GnRH‐glycys‐in both its free form and conjugated to the carrier PPD. Pre‐immunization priming with BCG was compared with non‐BCG priming. The results showed that BCG priming, in the absence of adjuvant, allowed a sufficient reduction in testosterone levels to occur without severely affecting gonadal changes. Immunization in conjunction with adjuvant resulted in high antibody titres, a decrease in testosterone levels, gonadal atrophy and a reduction in spermatogenesis. Alteration of the dose levels of the analogue and the long‐term effects of immunization on gondal function were also investigated. Keywords: Active immunizationGnRH analoguePPD conjugateimmunoneutralizationgonadal atrophytestosterone
Modifications of the Burrows and Wheeler data compression algorithm (1999)

We improve upon previous results on the Burrows and Wheeler (BW)-algorithm. Based on the context tree model, we consider the specific statistical properties of the data at the output of the BWT. We describe six important properties, three of which have not been described elsewhere. These considerations lead to modifications of the coding method, which in turn improve the coding efficiency. We briefly describe how to compute the BWT with low complexity in time and space, using suffix trees in two different representations. Finally, we present experimental results about the compression rate and running time of our method, and compare these results to previous achievements.
Injective and bounded distortion mappings in 3D (2013)

We introduce an efficient algorithm for producing provably injective mappings of tetrahedral meshes with strict bounds on their tetrahedra aspect-ratio distortion. The algorithm takes as input a simplicial map (e.g., produced by some common deformation or volumetric parameterization technique) and projects it on the space of injective and bounded-distortion simplicial maps. Namely, finds a similar map that is both bijective and bounded-distortion. As far as we are aware, this is the first algorithm to produce injective or bounded-distortion simplicial maps of tetrahedral meshes. The construction of the algorithm was made possible due to a novel closed-form solution to the problem of finding the closest orientation-preserving bounded-distortion matrix to an arbitrary matrix in three (and higher) dimensions. The algorithm is shown to have quadratic convergence, usually not requiring more than a handful of iterations to converge. Furthermore, it is readily generalized to simplicial maps of any dimension, including mixed dimensions. Finally, it can deal with different distortion spaces, such as bounded isometric distortion. During experiments we found the algorithm useful for producing bijective and bounded-distortion volume parameterizations and deformations of tetrahedral meshes, and improving tetrahedral meshes, increasing the tetrahedra quality produced by state-of-the-art techniques.
Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth (1997)

The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved for iron prior to infection. Similarly, the level of one of the proteins encoded by this operon, the aerobactin outer membrane receptor, Iut, was reduced in the intracellular environment. These studies indicate that the aerobactin system is not highly expressed by bacteria within host cells, suggesting that siderophore-independent iron acquisition systems can provide essential iron during intracellular multiplication.
Transmission of Paratuberculosis (1996)

Infection of the calf soon after birth by oral ingestion of M. paratuberculosis organisms from feces of infected cows is the most important method of transmission of paratuberculosis. The severity and rate of progression of the disease are dependent on the quantity of organisms in the exposure and the age of the animal. Only a small dose of organisms may be required to establish infection in a newborn calf, and overwhelming age-related resistance by introduction of a large dose of organisms to an adult cow is probably possible. Other means of transmission such as transplacental and direct excretion in the milk and colostrum should not be ignored and should be a particular concern primarily in advanced stages of infection when heavy fecal shedding is detected.
Mammalian stanniocalcins and cancer. (2003)

Stanniocalcin (STC) is a glycoprotein hormone that is secreted by the corpuscle of Stannius, an endocrine gland of bony fish, and is involved in calcium and phosphate homeostasis. The related mammalian proteins, STC1 and STC2, are expressed in a wide variety of tissues. The ovaries have the highest level of STC1, and this increases during pregnancy and lactation. STC1 is present in breast ductal epithelium, and its expression is induced by BRCA1, a tumor suppressor gene that has an important role in breast and ovarian cancer. The expression of STC2 is induced by estrogen, and there is a positive correlation between the level of expression of estrogen receptor and expression of both STC1 and STC2 in breast cancer. This article reviews the data currently available regarding the mammalian STCs, and discusses the roles they may play in normal physiology and in breast and other cancers.
An Autonomous Vehicle for Parcel Delivery in Urban Areas (2018)

The flexible and individualized transportation of goods is a central task of today's e-economy. In urban and highly populated areas autonomous electric vehicles are a promising solution for this task while simultaneously addressing ecological issues. While in indoor environments transport robots are well adopted, autonomous transport vehicles are hardly seen outdoors. In this paper, we aim at this gap and adapt and transfer concepts usually used in robotics to autonomous vehicles for an outdoor environment. We present an autonomous vehicle that is able to safely navigate in urban environments while able to deliver parcels efficiently. In particular, we will discuss a scalable and robust mapping and navigation process that forms the basis for the capabilities of the delivery vehicle. Moreover, we show preliminary results of a deployment of the system in two urban scenarios.
Analyses of 24-Hour Growth Hormone Profiles in Children: Relation to Growth* (1988)

The relationship between height and amount of GH measured during a 24-h period was studied in 127 children who were growing at different rates. Of the children, 88 were prepubertal (3-16 yr old) and 39 were pubertal (10-16 yr old). The height of each child was expressed as the SD score, i.e. height in relation to the sex- and age-matched Swedish reference groups, and spontaneous GH secretion was estimated by taking integrated 20-min blood samples for a 24-h period, i.e. 72 samples/child. In a few children, discrete samples were taken in parallel with the integrated 20-min samples with virtually the same results. Plasma GH was estimated in each sample using a polyclonal RIA method. To compare different 24-h GH profiles, the profiles were analyzed using a computer program (Pulsar). One objective of the study was to determine if less frequent sampling and/or shorter sampling periods yielded the same information as that obtained by 20-min sampling for the whole 24-h period. To determine if less frequent sampling provided the same information as that obtained by the 20-min period, we simulated 40- and 60-min periods by pooling two or three consecutive samples. No difference was found between 20- and 40-min sampling, but with 60-min sampling the mean calculated baseline plasma GH concentrations increased, and the GH concentration within peaks [the area under the curve above the baseline (AUCb)] decreased markedly. A 30-min sampling interval thus seems to be a valid practical compromise. To determine if sampling periods shorter than 24 h provided the same information, we divided the profiles, which started at 0900 h, into two 12-h, three 8-h and four 6-h periods. A graded decrease in AUCb and a corresponding increase in the baseline was found with the shorter periods, indicating that the whole 24-h period is necessary for GH sampling. Another objective of the study was to determine whether there was a correlation between 24-h GH secretion and the height, age, and sex of the children. In the prepubertal children, the height (in SD scores) was highly correlated (r = 0.69; P less than 0.001) with GH AUCb during the 24-h period. Height also correlated with AUCb estimated over shorter time periods; the correlation diminished with decreasing time. In the pubertal children, a nonlinear correlation (r = 0.36; P less than 0.05) was found between height and 24-h GH (AUCb).(ABSTRACT TRUNCATED AT 400 WORDS)
Inhibition of NO Production by Highly-Oxygenated Diterpenes of Orthosiphon stamineus and Their Structure-Activity Relationship. (2003)

Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure-activity relationship were established.
Mechanisms of effects of complement inhibition in murine collagen‐induced arthritis (2002)

These results indicate that inhibition of complement in CIA leads to decreased production of IgG2a antibody and suppressed CII-induced spleen cell proliferation. The greater inhibitory effects on CIA of anti-C5 antibody in comparison with Crry-Ig may be attributable primarily to decreased levels of IL-1beta and TNFalpha mRNA in the joints.
Peripheral vision and pattern recognition: A review (2011)

We summarize the various strands of research on peripheral vision and relate them to theories of form perception. After a historical overview, we describe quantifications of the cortical magnification hypothesis, including an extension of Schwartz's cortical mapping function. The merits of this concept are considered across a wide range of psychophysical tasks, followed by a discussion of its limitations and the need for non-spatial scaling. We also review the eccentricity dependence of other low-level functions including reaction time, temporal resolution, and spatial summation, as well as perimetric methods. A central topic is then the recognition of characters in peripheral vision, both at low and high levels of contrast, and the impact of surrounding contours known as crowding. We demonstrate how Bouma's law, specifying the critical distance for the onset of crowding, can be stated in terms of the retinocortical mapping. The recognition of more complex stimuli, like textures, faces, and scenes, reveals a substantial impact of mid-level vision and cognitive factors. We further consider eccentricity-dependent limitations of learning, both at the level of perceptual learning and pattern category learning. Generic limitations of extrafoveal vision are observed for the latter in categorization tasks involving multiple stimulus classes. Finally, models of peripheral form vision are discussed. We report that peripheral vision is limited with regard to pattern categorization by a distinctly lower representational complexity and processing speed. Taken together, the limitations of cognitive processing in peripheral vision appear to be as significant as those imposed on low-level functions and by way of crowding.
The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study (2006)

The Epidemiology of Diabetes Interventions and Complications (EDIC) study, an observational follow-up of the Diabetes Control and Complications Trial (DCCT) type 1 diabetes cohort, measured coronary artery calcification (CAC), an index of atherosclerosis, with computed tomography (CT) in 1,205 EDIC patients at approximately 7-9 years after the end of the DCCT. We examined the influence of the 6.5 years of prior conventional versus intensive diabetes treatment during the DCCT, as well as the effects of cardiovascular disease risk factors, on CAC. The prevalences of CAC >0 and >200 Agatston units were 31.0 and 8.5%, respectively. Compared with the conventional treatment group, the intensive group had significantly lower geometric mean CAC scores and a lower prevalence of CAC >0 in the primary retinopathy prevention cohort, but not in the secondary intervention cohort, and a lower prevalence of CAC >200 in the combined cohorts. Waist-to-hip ratio, smoking, hypertension, and hypercholesterolemia, before or at the time of CT, were significantly associated with CAC in univariate and multivariate analyses. CAC was associated with mean HbA(1c) (A1C) levels before enrollment, during the DCCT, and during the EDIC study. Prior intensive diabetes treatment during the DCCT was associated with less atherosclerosis, largely because of reduced levels of A1C during the DCCT.
West Nile Fever–a Reemerging Mosquito-Borne Viral Disease in Europe (1999)

West Nile virus causes sporadic cases and outbreaks of human and equine disease in Europe (western Mediterranean and southern Russia in 1962-64, Belarus and Ukraine in the 1970s and 1980s, Romania in 1996-97, Czechland in 1997, and Italy in 1998). Environmental factors, including human activities, that enhance population densities of vector mosquitoes (heavy rains followed by floods, irrigation, higher than usual temperature, or formation of ecologic niches that enable mass breeding of mosquitoes) could increase the incidence of West Nile fever.
Requirement of a corepressor for Dr1-mediated repression of transcription. (1996)

A Dr1-associated polypeptide (DRAP1) was isolated from HeLa cells and found to function as a corepressor of transcription. Corepressor function requires an interaction between DRAP1 and Dr1. Heterodimer formation was dependent on a histone fold motif present at the amino terminus of both polypeptides. Association of DRAP1 with Dr1 results in higher stability of the Dr1-TBP-TATA motif complex and precluded the entry of TFIIA and/or TFIIB to preinitiation complexes. DRAP1 was found to be expressed in all tissues analyzed with higher levels in tissues with a low mitotic index. Analysis of DRAP1 in the developing brain of rat demonstrated undetectable levels of DRAP1 in actively dividing cells but high levels of DRAP1 expression in differentiated non dividing cells. Dr1 was immunodetected in all cells analyzed. A model for DRAP1-dependent, Dr1-mediated repression of transcription is proposed.
Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes (2014)

We report the Pd-catalyzed α-arylation of α,α-difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α-difluoroketone constitutes a one-pot, two-step procedure to synthesize difluoromethylarenes from aryl halides. A broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent these two transformations, providing α-aryl-α,α-difluoroketones, difluoromethylarenes, and difluoromethylheteroarenes in high yields.
The Garden of Forking Paths in Visualization: A Design Space for Reliable Exploratory Visual Analytics : Position Paper (2018)

Turkey emphasized decades ago that taking exploratory findings as confirmatory is “destructively foolish”. We reframe recent conversations about the reliability of results from exploratory visual analytics - such as the multiple comparisons problem-in terms of Gelman and Loken's garden of forking paths to lay out a design space for addressing the forking paths problem in visual analytics. This design space encompasses existing approaches to address the forking paths problem (multiple comparison correction) as well as solutions that have not been applied to exploratory visual analytics (regularization). We also discuss how perceptual bias correction techniques may be used to correct biases induced in analysts' understanding of their data due to the forking paths problem, and outline how this problem can be cast as a threat to validity within Munzner's Nested Model of visualization design. Finally, we suggest paper review guidelines to encourage reviewers to consider the forking paths problem when evaluating future designs of visual analytics tools.
A task migration implementation of the Message-Passing Interface (1996)

In order to use networks of workstations in parallel processing applications, several schemes have been devised to allow processes on different, possibly heterogeneous, platforms to communicate with one another. The Message-Passing Interface (MPI) is one such scheme that allows for message-passing across different architectures. The MPI specification does not make provisions for the migration of a process between machines. This paper describes the work required to modify, an MPI implementation to allow for task migration. It also describes "Hector", our heterogeneous computing task allocator that is used to migrate tasks automatically and improve the overall performance of a parallel program.
Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease (2016)

Microvascular lesion in diabetic peripheral arterial disease (PAD) still cannot be resolved by current surgical and interventional technique. Endothelial cells have the therapeutic potential to cure microvascular lesion. To evaluate the efficacy and immune-regulatory impact of intra-arterial infusion of autologous CD133(+) cells, we recruited 53 patients with diabetic PAD (27 of CD133(+) group and 26 of control group). CD133(+) cells enriched from patients' PB-MNCs were reinfused intra-arterially. The ulcer healing followed up till 18 months was 100% (3/3) in CD133(+) group and 60% (3/5) in control group. The amputation rate was 0 (0/27) in CD133(+) group and 11.54% (3/26) in control group. Compared with the control group, TcPO2 and ABI showed obvious improvement at 18 months and significant increasing VEGF and decreasing IL-6 level in the CD133(+) group within 4 weeks. A reducing trend of proangiogenesis and anti-inflammatory regulation function at 4 weeks after the cells infusion was also found. These results indicated that autologous CD133(+) cell treatment can effectively improve the perfusion of morbid limb and exert proangiogenesis and anti-inflammatory immune-regulatory impacts by paracrine on tissue microenvironment. The CD133(+) progenitor cell therapy may be repeated at a fixed interval according to cell life span and immune-regulatory function.
Imaging-Assisted Endoscopic Surgery: Cleveland Clinic Experience (2008)

Imaging assistance beyond the endoscopic surgical view could increase the precision for and confidence of the surgeon, providing preoperative oncological data and understanding of the surrounding vital anatomies. Novel computer-based emerging techniques with 3D imaging technologies potentially indicate the ideal dissection plane to achieve better oncological outcomes as well as to maximize functional preservation.
Vapour Pressure Equations for the Metallic Elements: 298–2500K (1984)

Vapour pressure equations are presented for the metallic elements up to curium. For each element a precise four-term equation and a more practically-based equation have been derived from a new evaluation of thermochemical data for the condensed and gaseous elements. It is intended that the equations should be used for ideal gases in the pressure range 10−15–10−3 atm, which covers the experimentally accessible range. The “precise” equations reproduce the data to better than ±1% and the “practical” equations provide better than ±5% accuracy.
Screening of Metal−Organic Frameworks for Carbon Dioxide Capture from Flue Gas Using a Combined Experimental and Modeling Approach (2009)

A diverse collection of 14 metal-organic frameworks (MOFs) was screened for CO(2) capture from flue gas using a combined experimental and modeling approach. Adsorption measurements are reported for the screened MOFs at room temperature up to 1 bar. These data are used to validate a generalized strategy for molecular modeling of CO(2) and other small molecules in MOFs. MOFs possessing a high density of open metal sites are found to adsorb significant amounts of CO(2) even at low pressure. An excellent correlation is found between the heat of adsorption and the amount of CO(2) adsorbed below 1 bar. Molecular modeling can aid in selection of adsorbents for CO(2) capture from flue gas by screening a large number of MOFs.