gebhart/patrepeval huggingface dataset:
A trust model based routing protocol for secure ad hoe networks (2004)

Security issues have been emphasized when mobile ad hoc networks (MANETs) are employed into military and aerospace fields. We design a novel secure routing protocol for MANETs. This protocol TAODV (Trusted AODV) extends the widely used AODV (ad hoc on-demand distance vector) routing protocol and employs the idea of a trust model to protect routing behaviors in the network layer of MANETs. In the TAODV, trust among nodes is represented by opinion, which is an item derived from subjective logic. The opinions are dynamic and updated frequently as our protocol specification: if one node performs normal communications, its opinion from other nodes' points of view can be increased; otherwise, if one node performs some malicious behaviors, it is ultimately denied by the whole network. A trust recommendation mechanism is also designed to exchange trust information among nodes. The salient feature of TAODV is that, using trust relationships among nodes, there is no need for a node to request and verify certificates all the time. This greatly reduces the computation overheads. Meanwhile, with neighbors' trust recommendations, a node can make objective judgement about another node's trustworthiness to maintain the whole system at a certain security level.
Towards Tunable Sensitivity of Electrical Property to Strain for Conductive Polymer Composites Based on Thermoplastic Elastomer (2013)

The use of conductive polymer composites (CPCs) as strain sensors has been widely investigated and various resistivity-strain sensitivities are desirable for different applications. In this study, the use of mixed carbon fillers and functionalized carbon nanotubes was demonstrated to be vital for preparing thermoplastic polyurethane (TPU)-based strain sensors with tunable sensitivity. To understand the strain sensing behavior, we carried out scanning electron microscopy (SEM), Raman spectroscopy, wide-angle X-ray diffraction (WAXD), mechanical test, and rheology-electrical measurement. Hybrid fillers of multi-walled carbon nanotubes (MWNTs) and carbon black (CB) could reduce the entanglement in conductive network structure, thus increase the resistivity-strain sensitivity. Furthermore, incorporation of additional functionalized MWNTs in the CPCs could enhance the interfacial interaction between nanofillers and TPU, leading to further increase in sensitivity. Through such a simple method, strain sensors could be efficiently fabricated with large strain-sensing capability (strain as large as 200%) and a wide range of strain sensitivity (gauge factor ranging from 5 to 140238). Finally, the exponential revolution of resistive response to strain was fitted with a model based on tunneling theory by Simmons. It was observed that the change in tunneling distance and the number of conductive pathways could be accelerated significantly by adjusting conductive network structure and interfacial interaction. This study provides a guideline for the preparation of high-performance CPC strain sensors with a large range of resistivity-strain sensitivity.
The Relationship Between Self-Talk, Anxiety, and Counselling Skill. (1998)

Ninety-five participants from two graduate counsellor training programs were assessed onanxiety level, self-talk, and counselling skill. High anxiety reflected high negative self-talk, low positive self-talk, and poor video-tape performance.
Liposomes as Protein Carriers in Immunology (2004)

Liposomes are excellent carriers for protein antigens since they can contain large amounts of antigen, potentially in association with adjuvants. Liposomes may be made to mimic the pathogens that stimulated the evolution of the immune system. As such, numerous mechanisms exist to promote their uptake by antigen presenting cells and exposure of encapsulated antigens to the lymphocytes of the immune system for the induction of responses. The review is intended to describe the 30 year history of the use of liposomes are carriers of protein antigens, notably from the perspective of what we have learned about the immune system using liposomes.
Thermal Infrared Imaging-Based Computational Psychophysiology for Psychometrics (2015)

Thermal infrared imaging has been proposed as a potential system for the computational assessment of human autonomic nervous activity and psychophysiological states in a contactless and noninvasive way. Through bioheat modeling of facial thermal imagery, several vital signs can be extracted, including localized blood perfusion, cardiac pulse, breath rate, and sudomotor response, since all these parameters impact the cutaneous temperature. The obtained physiological information could then be used to draw inferences about a variety of psychophysiological or affective states, as proved by the increasing number of psychophysiological studies using thermal infrared imaging. This paper presents therefore a review of the principal achievements of thermal infrared imaging in computational physiology with regard to its capability of monitoring psychophysiological activity.
Stem cell donation – What advice can be given to the donor? (2009)

Haematopoietic stem cell transplantation (HSCT) is widely used to treat patients with a range of haematological and non-haematological disorders. Both bone marrow and peripheral blood stem cell collection are associated with morbidity and, very rarely, mortality. We investigated the information that exists to adequately inform donors about the relative merits of each procedure. We carried out a systematic review analysing data from six prospective randomised controlled trials of related donors and discuss here the merits and drawbacks of this approach. Registry data mostly describes patient outcome but stem cell donor registries collect and report information on unrelated donors which could easily be extended to related donors. Further well-designed, randomised studies are required.
CARDIAC ALLOGRAFT PROLONGATION IN MICE TREATED WITH COMBINED POSTTRANSPLANTATION TOTAL-LYMPHOID IRRADIATION AND ANTI-L3T4 ANTIBODY THERAPY (1989)

Neonatal cardiac allograft survival was examined in mice treated with anti-L3T4 antibody, posttransplantation total lymphoid irradiation (TLI) or a combination of both therapies. Independently, both posttransplantation TLI and short-course antibody treatment allowed minimal prolongation. However, synergistic prolongation in graft survival was observed with the combination (synergistic) therapy. Fluorescence-activated cell sorter analysis of peripheral blood lymphocytes from animals treated with combined anti-L3T4 and posttransplantation TLI additionally revealed "synergy" with respect to the degree of peripheral lymphocyte depletion.
Efficiency of homologous DNA recombination varies along the Bacillus subtilis chromosome (1988)

Structures consisting of a genetic marker (erythromycin or kanamycin resistance, thymidylate synthetase) flanked by 3.4-kilobase direct repeats (pBR322 sequences) were inserted in 12 different locations of the Bacillus subtilis chromosome. Recombination between the repeats was followed by the loss of the genetic marker. Recombination frequencies found in different locations varied from 1.2 X 10(-5) to 40 X 10(-5) per cell generation. Such differences were highly significant (P less than 0.001).
Is the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase a Rate-Limiting Step for Isoprenoid Biosynthesis in Plants? (1995)

3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the irreversible conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate and is considered a key regulatory step controlling isoprenoid metabolism in mammals and fungi. The rate-limiting nature of this enzyme for isoprenoid biosynthesis in plants remains controversial. To investigate whether HMGR activity could be limiting in plants, we introduced a constitutively expressing hamster HMGR gene into tabacco (Nicotiana tabaccum L.) plants to obtain unregulated HMGR activity. The impact of the resulting enzyme activity on the biosynthesis and accumulation of particular isoprenoids was evaluated. Expression of the hamster HMGR gene led to a 3- to 6-fold increase in the total HMGR enzyme activity. Total sterol accumulation was consequently increased 3- to 10-fold, whereas end-product sterols such as sitosterol, campesterol, and stigmasterol were increased only 2-fold. The level of cycloartenol, a sterol biosynthetic intermediate, was increased more than 100-fold. Although the synthesis of total sterols appears to be limited normally by HMGR activity, these results indicate that the activity of one or more later enzyme(s) in the pathway must also be involved in determining the relative accumulation of end-product sterols. The levels of other isoprenoids such as carotenoids, phytol chain of chlorophyll, and sesquiterpene phytoalexins were relatively unaltered in the transgenic plants. It appears from these results that compartmentation, channeling, or other rate-determining enzymes operate to control the accumulation of these other isoprenoid end products.
Chromium picolinate supplementation for diabetes mellitus. (1998)

Chromium picolinate is a widely available nutritional supplement marketed for a plethora of afflictions. There is some evidence, including results from human studies, that it has a role in glucose homeostasis. We report the case of a 28-year-old woman with an 18-year history of type 1 diabetes mellitus whose glycosylated hemoglobin (Hb A1c) declined from 11.3% to 7.9% 3 months after initiation of chromium picolinate, 200 micrograms 3 times daily. Chromium picolinate continues to fall squarely within the scope of "alternative medicine," with both unproven benefits and unknown risks. It deserves closer scrutiny with additional prospective, randomized, double-blind, placebo-controlled trials to evaluate its efficacy in improving outcomes in patients with diabetes. A brief review of the literature was done to assist physicians who are being called upon to counsel and treat patients who are engaging in alternative therapies.
Vague objects and identity (1989)

Journal Article Vague objects and identity Get access D. E. Over D. E. Over Sunderland PolytechnicSunderland SRI 3SD Search for other works by this author on: Oxford Academic Google Scholar Analysis, Volume 49, Issue 3, June 1989, Pages 97–99, https://doi.org/10.1093/analys/49.3.97 Published: 01 June 1989
Intra-Assay Performance Characteristics of Five Assays for Quantification of Human Immunodeficiency Virus Type 1 RNA in Plasma (1998)

Three kits (Roche AMPLICOR human immunodeficiency virus type 1 [HIV-1] Monitor, Chiron enhanced-sensitivity bDNA, and Organon Teknika NASBA HIV-1 QT) and two in-house assays (from National Genetics Institute and Baylor College of Medicine) were compared with a blinded panel. The results were evaluated as to intra-assay sensitivity, precision, and ability to detect differences in a dilution series.
NOKIA CORPORATION v IPCOM GMBH & CO KG (No. 2) (2012)

H1 Patents—Amendment—Added matter—Partial validity—Infringement—Damages and other financial relief—Whether claim for damages and costs to be struck out for failure to comply with order requiring provision of further information—Privilege—Whether specification framed “in good faith and with reasonable skill and knowledge”
Purification and Properties of Acid Stable Xylanases fromAspergillus kawachii (1992)

Five extracellular endo-xylanases were recognized in the culture broth of shochu koji mold (Aspergillus kawachii, IFO 4308), and three major xylanases (XylA, XylB, and XylC) were purified and characterized. The molecular masses of XylA, XylB, and XylC were 35,000, 26,000, and 29,000, and isoelectric points were pH 6.7, 4.4, and 3.5, respectively. Amino acid compositions and other properties were studied and these three xylanases were found to be greatly different in their properties. These three xylanases, XylA, XylB, and XylC, were stable between pH 3-10, 3-10, and 1-9 and the optimum pHs were 5.5, 4.5, and 2.0, respectively. Consequently, these xylanases were acid stable xylanases, especially XylC was an acidophilic xylanase (acid xylanase). These xylanases produced various xylooligosaccharides including xylose from xylan and the main product was xylobiose in all xylanases. The production of acid xylanase (XylC) was enhanced with a low initial pH of the medium.
Primary structure determination of Escherichia coli heat-stable enterotoxin of porcine origin (1983)

The chemical characterization of Escherichia coli heat-stable enterotoxin (ST) is described. The toxin was isolated and purified to homogeneity from the E. coli strain F11 (PI55) of porcine origin. Following quantitative amino acid analysis, the enterotoxin was found to contain 18 amino acids including 6 cysteines, but was devoid of Ser, Val, Met, Ile, Lys, His, and Arg residues. All cysteine residues were found to be involved in disulfide bridges, even though their positions could not be localized. The enterotoxin thus has a molecular weight of 1979 and was shown to be an octadecapeptide with the following sequence: H2N-Asn-Thr-Phe-Tyr-Cys-Cys-Glu-Leu-Cys-Cys-Asn-Pro-Ala-Cys-Ala-Gly-Cys-Tyr- COOH. Its relationship to other known enterotoxins is discussed.
Molecular Mechanisms of Immunosuppression by Cyclosporins (1993)

Despite the successful clinical application of the immunosuppressive drug cyclosporin A (CsA, Sandimmun), its precise mechanism of action in the process of T cell activation remains elusive. CsA binds to the high-affinity cytosolic receptor cyclophilin whose peptidyl-prolyl cis-trans isomerase activity is inhibited upon binding. The linkage of this effect with the inhibition of the T cell receptor-mediated signal transduction pathway, which leads to a suppression of lymphokine gene transcription, is still unclear. We analyzed the relationship between cyclophilin-binding and immunosuppressive activity (e.g., effect on IL-2 transcription) of cyclosporin derivatives in vitro. The results show that binding to cyclophilin is required, but not sufficient for immunosuppression. Cyclosporin analogues which completely lack immunosuppressive activity but fully retained their cyclophilin-binding capacity antagonize the immunosuppressive activity of CsA. These derivatives inhibit the isomerase activity of cyclophilin, which clearly demonstrates that inhibition of the cyclophilin isomerase activity does not lead to immunosuppression. In analogy to the other immunosuppressants of microbial origin, FK-506 and rapamycin, a specific structure of the "effector" domain of CsA, which is unrelated to the cyclophilin-binding domain, determines the biological activity. In the nucleus, CsA interferes with the DNA-binding of inducible transcription factors to their respective DNA motifs within lymphokine promoters by affecting intracellular translocation of transcription factor subunits.
Circulating human papillomavirus DNA as a marker for disease extent and recurrence among patients with oropharyngeal cancer (2015)

Pretreatment serum HPV DNA was associated with higher N category and overall disease stage. However, pretreatment serum HPV DNA does not appear to have clinical usefulness as a marker for disease recurrence among patients with OPC.
Antibody-mediated neutralization in vivo of infectious papillomaviruses (1990)

Specific antibody-mediated neutralization of infectious human papillomavirus type 11 (HPV-11) was achieved in the athymic mouse xenograft system, in which HPV-11 induced morphological transformation of human foreskin. Virus-specific neutralization was demonstrated by the ability of an HPV-11-specific polyclonal antiserum to neutralize HPV-11 infectivity and not bovine papillomavirus type 1 (BPV-1) or cottontail rabbit papillomavirus (CRPV) infectivity. In all three virus infectivity systems, neutralization was detected by the failure of the virus suspension to induce morphological transformation of the appropriate skin xenografts placed under the renal capsule of athymic mice. Rabbit polyclonal antisera were also generated against intact virions of both BPV-1 and CRPV, and neutralizing activity was tested in the xenograft system with BPV-1 and fetal bovine skin and with CRPV and rabbit ear skin. The three polyclonal antisera contained virus-specific neutralizing antibodies, demonstrating that neutralizing epitopes existed on all three papillomaviruses and that these epitopes were antigenically non-cross-reactive. The athymic mouse xenograft system was a useful model for detecting papillomavirus-specific neutralizing antibodies and offers the only opportunity for the analysis of neutralizing antibodies to human papillomaviruses.
Selection of single chain variable fragments (scFv) against the glycoprotein antigen of the rabies virus from a human synthetic scFv phage display library and their fusion with the Fc region of human IgG1 (2001)

We have prepared human recombinant antibody molecules against the glycoprotein antigen of the rabies virus (GPRV) based on the single chain variable fragment (scFv) format. Anti-GPRV scFvs were selected from a human synthetic scFv phage display library with a repertoire of approximately 109 specificities. After three rounds of selection against the PV11 strain of the virus, 40% of the clones tested recognized the rabies antigen. Of the 20 positive clones that were sequenced, five distinct sequences were identified. These distinct scFvs were cloned into a mammalian expression vector carrying the human IgG1 Fc region. The specificity of the resulting scFv-Fc molecules for GPRV was established by ELISA, dot blot and western blot analyses and membrane immunofluorescence. Two of the scFv-Fc fusion proteins neutralized the PV11 strain in a standard in vivo neutralization assay where the virus was incubated with the scFv-Fc molecules before intracranial inoculation in mice. These anti-GPRV scFv-Fc molecules have the potential to be used as an alternative to the presently available HRIG, for use in post-exposure preventive treatment.
Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system (2007)

The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described. Prior to use, the glass apertures were rendered hydrophobic by a silanization process and were then incorporated into a simple microfluidic device. Successful bilayer lipid membrane (BLM) formation and the subsequent acquisition of single-channel recordings are demonstrated. Due to the simplicity and rapidity of the SACE process, these glass apertures could be easily integrated into an all-glass microfluidic system for BLM formation.
Optimal-resilience proactive public-key cryptosystems (2002)

We introduce new efficient techniques for sharing cryptographic functions in a distributed dynamic fashion. These techniques dynamically and securely transform a distributed function (or secret sharing) representation between t-out-of-l (polynomial sharing) and t-out-of-t (additive sharing). We call the techniques poly-to-sum and sum-to-poly, respectively. Employing these techniques, we solve a number of open problems in the area of cryptographic function sharing. We design a threshold function sharing scheme with proactive security for general functions with a "homomorphic property" (a class which includes all RSA variants and Discrete logarithm variants). The sharing has "optimal resilience" (server redundancy) and enables computation of the function by the servers assuring high availability, security and efficiency. Proactive security enables function sharing among servers while tolerating an adversary which is mobile and which dynamically corrupts and abandons servers (and perhaps visits all of them over the lifetime of the system, as long as the number of corruptions (faults) is bounded within a time period). Optimal resilience assures that the adversary can corrupt any minority of servers at any time-period.
First Row Transition Metal Aminopyridinates – the Missing Complexes (2009)

Abstract Lithiated 4‐methyl‐2‐[(trimethylsilyl)amino]pyridine (Ap TMS H) undergoes a salt metathesis reaction with [ScCl 3 (thf) 3 ] and FeCl 3 , at low temperature in thf, to yield the homoleptic complexes [Sc(Ap TMS ) 3 ] ( 1 ) and [Fe(Ap TMS ) 3 ] ( 2 ). An analogous reaction with MnCl 2 , CoCl 2 and FeCl 2 using two equivalents of 4‐ tert ‐butylpyridine ( t BuPy) as additional donor ligand affords the structurally analogous cis complexes [Mn(Ap TMS ) 2 ( t BuPy) 2 ] ( 3 ), [Co(Ap TMS ) 2 ( t BuPy) 2 ] ( 4 ) and [Fe(Ap TMS ) 2 ( t BuPy) 2 ] ( 5 ). If FeCl 2 is used without t BuPy, the highly symmetric trinuclear complex [Fe 3 (Ap TMS ) 6 Li 2 O] ( 6 ) is obtained. Furthermore, the use of ZnCl 2 in a reaction with lithiated Ap TMS H yields the dimeric complex [Zn 2 (Ap TMS ) 4 ] ( 7 ) in which two Ap TMS ligands bridge the two metals. All complexes have been characterised by X‐ray crystal structure analysis. To the best of our knowledge, complexes 1 and 2 and 5 are the first scandium and iron aminopyridinates, respectively, and complex 3 is the first manganese aminopyridinate complex which contains no additional anionic ligand. Complexes 4 and 7 are rare examples of cobalt and zinc aminopyridinates. This study proves that aminopyridinato ligands are highly universal ligands since they are able to stabilize early and late transition metals. Aminopyridinates of every first row transition metal are now available. The magnetic properties of all paramagnetic complexes were investigated. All complexes are high‐spin complexes and the trinuclear iron complex 6 exhibits a weak antiferromagnetic coupling.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
Firing the genie: Two-phase short-blocklength convolutional coding with feedback (2013)

In an effort to account for the latency cost of error detection at short blocklengths, we simulate a two-phase feedback-based incremental redundancy scheme. This scheme consists of communication and confirmation phases, as used in the error exponent literature, and allows messages to be decoded with high reliability. Simulation results of tail-biting convolutional codes on the AWGN channel are shown, which demonstrate that the two-phase scheme can deliver throughput surpassing the random coding lower bound on variable-length feedback (VLF) code achievability. A comparison with simulation of CRC-based error detection is also presented.
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. (1997)

In hypercholesterolemia, impaired nitric oxide activity has been associated with increased nitric oxide degradation by oxygen radicals. Deficiency of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase, causes both impaired nitric oxide activity and increased oxygen radical formation. In this study we tested whether tetrahydrobiopterin deficiency contributes to the decreased nitric oxide activity observed in hypercholesterolemic patients. Therefore, L-mono-methyl-arginine to inhibit basal nitric oxide activity, serotonin to stimulate nitric oxide activity, and nitroprusside as endothelium-independent vasodilator were infused in the brachial artery of 13 patients with familial hypercholesterolemia and 13 matched controls. The infusions were repeated during coinfusion of L-arginine (200 microg/kg/min), tetrahydrobiopterin (500 microg/min), or the combination of both compounds. Forearm vasomotion was assessed using forearm venous occlusion plethysmography and expressed as ratio of blood flow between measurement and control arm (M/C ratio). Tetrahydrobiopterin infusion alone did not alter M/C ratio. Both the attenuated L-mono-methyl-arginine-induced vasoconstriction as well as the impaired serotonin-induced vasodilation were restored in patients during tetrahydrobiopterin infusion. Tetrahydrobiopterin had no effect in controls. In conclusion, this study demonstrates restoration of endothelial dysfunction by tetrahydrobiopterin suppletion in hypercholesterolemic patients.