gebhart/patrepeval huggingface dataset:
Customizing mobile applications (1993)

The dynamics of mobile systems require applications to intelligently adapt to changes in system configurations and to their environment. We describe a workplace in which users interact with a number of stationary and mobile systems through the course of a day. The relationship between systems and devices is constantly changing due to user mobility. We present a facility for mobile application customization called &amp;quot;dynamic environment variables.&amp;quot; The facility allows flexible sharing of customization contexts, supports short interactions with long term services, and provides efficient notification of environment changes to applications. A sample application built in PARC&amp;apos;s mobile computing environment and initial performance evaluations are described. 1 Introduction Mobile computing differs from desktop computing because of the dynamic nature of system state. In our research lab mobile users interact with mobile computers as well as a world of stationary and embedded systems [8]. As use...
Infliximab induces potent anti‐inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn’s disease (2001)

The clinical efficacy of infliximab is based on local anti-inflammatory and immunomodulatory effects in the bowel mucosa, without generalized suppression of systemic immune functions in Crohn's disease patients.
On the M-CubITS pedestrian navigation system (2006)

This paper describes construction of the M-CubITS pedestrian WYSIWYAS navigation system both in outdoor and indoor areas, toward realization of the M-CubITS pedestrian WYSIWYAS navigation environment. In outdoor navigation, we construct the experimental Saitama University campus outdoor navigation system "CamNavi" using ordinary mobile phone terminals as users' terminals and the i-application platform provided by Japanese NTT DoCoMo. Here, our studies on the outdoor system are mainly based on image processing for outdoor M-CubITS elements and a user interface for the mobile phone terminals. On the other hand, in indoor navigation, we also introduce the route guidance using the Dijkstra method and study databases. Then, we construct an experimental system at the seven-storied buildings in the faculty of engineering, Saitama University, and check the system operation
<title>Development of the spatial heterodyne spectrometer for VUV remote sensing of the interstellar medium</title> (2001)

This paper discusses the scientific motivation for, design of and buildup of the Spatial heterodyne Spectrometer (SHS) for a sounding rocket mission to study the Cygnus Loop, a prototypical middle-ages supernova remnant. The results of that mission are also presented. The goal of the flight was to obtain a radial velocity-resolved spectrum of the C IV (lambda) 1550 emission line from the Cygnus Loop, as a test for doing the same from the diffuse hot interstellar medium (ISM). The reasons for wanting to look at the ISM this way are discussed, along with the properties of SHS. Important points about alignment (zero-path and zero-spatial-frequency setting), as well as shake testing and data analysis techniques (fringe correction, thermal drift tracking) are described. The SHS payload did not obtain a spectrum for th Cygnus Loop C IV emission line, because of reduced efficiency of the optical components. Results of post- flight efficiency tests to locate the source(s) of this loss are presented, showing contamination as the most likely problem. Ways to eliminate this contamination for future SHS sounding rocket and satellite missions conclude the presentation.
Immunogenicity of lipid-conjugated antigens. I. The influence of chain length and degree of conjugation on induction of antibody in mice. (1980)

An experiments in mice with a range of human serum albumin (HSA) molecules acylated to various degrees with side-chains of 6--20 carbon atoms, the greatest antibody responses against HSA were induced by highly acylated HSA with side-chains of intermediate length (C10--14). Similar results were obtained in rats but in this species the highest acylations with a particular chain length more often induced a less than optimal response. Mouse sera produced in response to acylated antigens and absorbed with HSA itself did not detectably react with acylated HSA when tested by an ammonium sulphate precipitation method. Acylation of antigen may sometimes reduce immunogenicity as shown in experiments with diphtheria toxoid.
In vivo animal studies with sugammadex (2009)

A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on other organs. These results offer support for the further development of sugammadex for clinical use in humans.
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target. (2001)

We report that the photosensitizer verteporfin kills lymphoma cells by an apoptotic process involving a dissipation of the mitochondrial inner transmembrane potential (deltapsim). Light-activated verteporfin-induced apoptosis was abolished by transfection with Bcl-2, a procedure reported to inhibit the mitochondrial permeability transition pore complex (PTPC). Verteporfin triggered the deltapsim loss in isolated mitochondria in vitro, and this effect was suppressed by bongrekic acid and cyclosporin A. Verteporfin plus light also permeabilized proteoliposomes containing the semipurified PTPC or the purified PTPC component adenine nucleotide translocator (ANT), yet had no effect on protein-free control liposomes. Verteporfin phototoxicity on ANT proteoliposomes was mediated by reactive oxygen species and was prevented by recombinant Bcl-2 or the adenine nucleotides ATP and ADP. In conclusion, verteporfin belongs to a class of clinically used chemotherapeutic agents acting on PTPC and ANT.
A study of porosity and permeability using a lattice Boltzmann simulation (1998)

We explicitly calculate the absolute (single‐phase) permeability of simulated granular rocks as the pore space is evolved by various diagenetic schemes. Our goal is to match our computed curves to laboratory measurements of porosity‐permeability relationships in real rocks. To achieve this goal we model rock as a dense random pack of identical spherical grains with diagenetic cement deposited in the pore space. The positions of the sphere centers in our numerical model are taken from experimental measurements (the Finney pack). The diagenesis is simulated in various ways: uniform cement deposition on the surface of each grain (uniform growth of the grains); cement deposition at grain contacts; cement deposition away from grain contacts; random filling of the pore spaces; and various combinations of these. Permeability is computed by explicitly modeling Stokes flow in the simulated pore space using a lattice Boltzmann method. Our simulations produce distinctively different porosity‐permeability relationships which are characteristic of the cement deposition pattern. The distinctive porosity‐permeability relationships found in laboratory measurements of real rocks are matched by certain simulation schemes.
Universal fiber-optic point sensor system for quasi-static absolute measurements of multiparameters exploiting low coherence interrogation (1996)

A universal fiber-optic high-resolution point sensor system, based upon signal recovery by dual-wavelength low coherence interferometry, has been developed and demonstrated for quasistatic absolute measurements of multiparameters. This system is capable of multiplexing up to 32 fiber-optic point sensors which can be fiber optic interferometers or fiber Bragg gratings or any combination of the two. The topology of this system is based on a spatially multiplexed scheme with low coherence signal recovery that we have reported previously. A range of multiparameter point sensors, including a medium pressure sensor, a high pressure sensor, a miniature temperature sensor, a displacement sensor, and a fiber Bragg grating strain sensor with drift-compensation, have been developed and incorporated into this network and demonstrated A range to resolution of better than 10/sup 4/:1 and 2/spl times/10/sup 3/:1 has been achieved for the interferometric sensors and the Bragg grating strain sensor, respectively. The interchangeability of the sensors has also been demonstrated, allowing the sensors to be replaced in the event of damage. Due to the universality of the signal interrogation, the instrument can be compatible with any interferometric point sensor which has a similar optical path difference with the transmitting interferometer or any fiber grating sensor whose normal wavelength is within the spectral range of the light source. In addition, as the total sensor number which can be multiplexed is quite large, the average cost for each sensor is reduced considerably. Therefore, this system allows optical fiber sensors to compete with conventional sensors with the additional benefits of fiber-optic sensors.
Adenovirus helper function for growth of adeno-associated virus: effect of temperature-sensitive mutations in adenovirus early gene region 2 (1980)

Adeno-associated virus (AAV) grows efficiently only in cells that are also infected with an adenovirus (Ad). We employed Ad mutants to determine which genes may be required for the AAV helper function. Two mutants of Ad type 5 (Ad5), Ad5ts125 and Ad5ts107, with temperature-sensitive lesions in the E72 DNA-binding protein coded by the Ad early region 2, were deficient for AAV helper functions at the nonpermissive temperature (40 degrees C). In contrast, Ad5ts149, with a temperature-sensitive lesion in the Ad early region 5, was an efficient helper of AAV at the nonpermissive temperature. In KB cells, with the Ad5ts125 or Ad5ts107 mutant as the helper, the accumulation of AAV capsid proteins and AAV particles was decreased by about two logs, whereas AAV DNA synthesis was decreased only severalfold. Cytoplasmic, polyadenylic acid-containing AAV RNA is composed of a set of overlapping, spliced RNAs having different 5' start points. With the ts125 helper at 40 degrees C there was a decreased accumulation of some but not all of these AAV RNAs. The Ad5 E72 protein may have an effect on transcription or more likely posttranscriptional processing of AAV RNA. These observations suggest additional pleiotropic effects of the multifunctional E72 protein and suggest further similarities in the actions of E72 and the simian virus 40 T-antigen.
The Decline of Professionalism (2018)

t is my hope that the subject of my remarks today, the decline of professionalism, meets the stern criteria defined by the Founder of the Society, Benjamin Franklin. In fixing the standard of promoting luseful knowledge:' Walter Massey wrote that Franklin's purpose was to stimulate ideas worthwhile to society. A serious decline in professionalism in any of the learned professions is inevitably injurious to the society in which it functions, and in order to evaluate the seriousness of such a decline, one must examine the setting in which that decline occurs. We must ask whether it is isolated and peculiar to one profession or whether there is also a decline in other professions and other human activities. I see disturbing evidence that there has been a broad decline in professionalism over the past twenty or twenty-five years, not only in the three learned professions in the clergy, in medicine, and in the law-but in many other important activities. For example, those who serve in the money markets including Wall Street, in banks, and in savings and loan institutions -have inflicted severe damage on the public. Some have called this period a Greed Era. The decline of professionalism, especially in the law, has taken on epidemic dimensions. I do not make such a statement lightly. John J. Yanas, President of the New York State Bar Association, recently stated: Greed and avarice seem to permeate every facet of life in this country and the practice of law has not proven to be immune. . He then goes on to state:
Keratinocyte-derived chemokine is an early biomarker of ischemic acute kidney injury (2005)

Renal ischemia-reperfusion injury (IRI) is the leading cause of acute kidney injury [AKI; acute renal failure (ARF)] in native kidneys and delayed graft function in deceased donor kidney transplants. Serum creatinine rises late after renal IRI, which results in delayed diagnosis. There is an important need to identify novel biomarkers for early diagnosis and prognosis in renal IRI. Given the inflammatory pathophysiology of renal IRI, we used a protein array to measure 18 cytokines and chemokines in a mouse model of renal IRI at 3, 24, and 72 h postischemia. A rise in renal keratinocyte-derived chemokine (KC) was the earliest and most consistent compared with other molecules, with 3-h postischemia values being 9- and 13-fold greater than sham and normal animals, respectively. Histological changes were evident within 1 h of IRI but serum creatinine only increased 24 h after IRI. With the use of an ELISA, KC levels in serum and urine were highest 3 h postischemia, well before a significant rise in serum creatinine. The human analog of KC, Gro-alpha, was markedly elevated in urine from humans who received deceased donor kidney transplants that required dialysis, compared with deceased donor kidney recipients with good graft function and live donor recipients with minimal ischemia. Measurement of KC and its human analog, Gro-alpha, could serve as a useful new biomarker for ischemic ARF.
Chemotherapy-Induced Nausea and Vomiting: Challenges and Opportunities for Improved Patient Outcomes (2009)

Oncology nurses play a pivotal role in the care of patients receiving chemotherapy and are in a prime position to facilitate better care of patients experiencing chemotherapy-induced nausea and vomiting (CINV). However, to do so, they must be kept well apprised of the most recent guidelines, the latest developments in CINV therapy, and the expanding knowledge of CINV pathophysiology. In April 2008, a roundtable meeting of experts in the field of CINV was convened after a detailed needs assessment revealed a knowledge gap in CINV management on the part of oncology nurses. The review found that many practitioners significantly underestimated the occurrence of CINV (particularly of delayed symptoms), and others failed to implement evidence-based guidelines. Presentations included CINV pathophysiology, the significance of CINV prophylaxis, evidence-based guidelines, current treatment options and future therapies, practical nursing considerations in CINV, and CINV learning gaps among oncology nurses, with the topics then discussed by the panel at large.
Targeting and Readout Strategies for Fast Optical Neural ControlIn VitroandIn Vivo (2007)

### Introduction Major obstacles faced by neuroscientists in attempting to unravel the complexity of brain function include both the heterogeneity of brain tissue (with a multitude of cell types present in vivo ) and the high speed of brain information processing (with behaviorally relevant
Tryprostatin A, a specific and novel inhibitor of microtubule assembly (1998)

We have investigated the cell cycle inhibition mechanism and primary target of tryprostatin A (TPS-A) purified from Aspergillus fumigatus. TPS-A inhibited cell cycle progression of asynchronously cultured 3Y1 cells in the M phase in a dose- and time-dependent manner. In contrast, TPS-B (the demethoxy analogue of TPS-A) showed cell-cycle non-specific inhibition on cell growth even though it inhibited cell growth at lower concentrations than TPS-A. TPS-A treatment induced the reversible disruption of the cytoplasmic microtubules of 3Y1 cells as observed by indirect immunofluorescence microscopy in the range of concentrations that specifically inhibited M-phase progression. TPS-A inhibited the assembly in vitro of microtubules purified from bovine brains (40% inhibition at 250 microM); however, there was little or no effect on the self-assembly of purified tubulin when polymerization was induced by glutamate even at 250 microM TPS-A. TPS-A did not inhibit assembly promoted by taxol or by digestion of the C-terminal domain of tubulin. However, TPS-A blocked the tubulin assembly induced by inducers interacting with the C-terminal domain, microtubule-associated protein 2 (MAP2), tau and poly-(l-lysine). These results indicate that TPS-A is a novel inhibitor of MAP-dependent microtubule assembly and, through the disruption of the microtubule spindle, specifically inhibits cell cycle progression at the M phase.
Letter (2000)

A new century dawns, but some things will never change. Cheshire and Manchester trusts are dogmatically specifying the colour of tights staff may wear. Do you think this is a gender issue? Inane traditions look set to continue - how nice to be part of a mature profession.
DOE Hydrogen and Fuel Cells Program Budget (2012)

Budget information for hydrogen and fuel cell research, development, and other activities at the U.S. Department of Energy (DOE) is provided here. Included are budgets for DOE's Offices of Energy Efficiency and Renewable Energy, Fossil Energy, Nuclear Energy, and Science.
Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice (2008)

Current anticancer therapy is a delicate balance between elimination of malignant cells and harmful side effects for the host. In this study, we used a tumor-homing peptide to engineer anti-CD40 agonist antibodies and recombinant IL-2 such that they were selectively delivered into spontaneously arising tumors in a transgenic mouse model of islet cell carcinogenesis. Intravenous injection of these agents, either separately or together, led to accumulation in the vicinity of tumor neovessels without toxic side effects. Although both molecules are critical for adaptive immunity, the most profound effects were seen in endothelial cells. Combined, local anti-CD40 and IL-2 therapy reduced tumor vascularity and significantly delayed tumor growth in mice. Remarkably, tumor-bearing mice remained disease-free long-term when targeted anti-CD40 and IL-2 were combined with transfers of preactivated antitumor immune cells. In this therapeutic setting, triggering of CD40 on endothelial cells induced an inflammatory response of the vessel wall and facilitated effector cell accumulation in the tumor parenchyma while IL-2 promoted antigen-specific immune cell persistence. We believe this is a novel and highly effective anticancer approach, whereby tumor stroma is "conditioned" for enhanced immune cell entry and survival, facilitating immune-mediated tumor destruction and leading to a sustained antitumor response.
Lasing wavelength changes due to degradation in buried heterostructure distributed Bragg reflector lasers (1999)

Changes in the wavelength and lamp characteristics due to the degradation of distributed Bragg reflector (DBR) lasers are investigated and the lasers are confirmed to be reliable enough for application as the light sources in WDM systems. The change in wavelength characteristics is due to degradation of the DBR or phase control region and the change in lamp characteristics is due to the degradation of active region. These changes in the characteristics are caused by diminished recombination carrier lifetime. The wavelength stability is strongly correlated with the injected current density. The lamp characteristics is confirmed to be almost as stable as in conventional Fabry-Perot lasers. The applicability of DBR lasers as the light source for wavelength division multiplexing (WDM) systems is demonstrated for actual-use conditions.
Self-focusing and self-defocusing by cascaded second-order effects in KTP (1992)

We monitor the induced phase change produced by a cascaded chi((2)):chi((2)) process in KTP near the phase-matching angle on a picosecond 1.06-microm-wavelength beam using the Z-scan technique. This nonlinear refraction is observed to change sign as the crystal is rotated through the phase-match angle in accordance with theory. This theory predicts the maximum small-signal effective nonlinear refractive index of n(eff)(2) congruent with +/-2 x 10(-14) cm(2)/W (+/-1 x 10(-11) esu) for an angle detuning of +/-5 degrees from phase match for this 1-mm-thick crystal with a measured d(eff) of 3.1 pm/V. For a fixed phase mismatch, this n(eff)(2) scales linearly with length and as d(eff)(2) however, for the maximum n(eff)(2) the nonlinear phase distortion becomes sublinear with irradiance for phase shifts near pi/4.
Indocyanine green increases light‐induced oxidative stress, senescence, and matrix metalloproteinases 1 and 3 in human RPE cells (2010)

In this study, pretreatment with ICG significantly increased light-induced oxidative stress and senescence. This might indicate a potential, supplementary mechanism that could explain RPE alterations and reduced functional results after ICG-assisted internal limiting membrane peeling.
Querying text databases for efficient information extraction (2004)

A wealth of information is hidden within unstructured text. This information is often best exploited in structured or relational form, which is suited for sophisticated query processing, for integration with relational databases, and for data mining. Current information extraction techniques extract relations from a text database by examining every document in the database, or use filters to select promising documents for extraction. The exhaustive scanning approach is not practical or even feasible for large databases, and the current filtering techniques require human involvement to maintain and to adapt to new databases and domains. We develop an automatic query-based technique to retrieve documents useful for the extraction of user-defined relations from large text databases, which can be adapted to new domains, databases, or target relations with minimal human effort. We report a thorough experimental evaluation over a large newspaper archive that shows that we significantly improve the efficiency of the extraction process by focusing only on promising documents.
Light field acquisition using wedge-shaped waveguide (2013)

We proposed the light field acquisition system using the wedge-shaped waveguide. To obtain the light field reflected from the object, the lens array is mounted on the wedge-shaped waveguide. The light field information is forwarded through the waveguide and captured. In the experiment, we obtained the light field image variant with the object distance.
Endothelin stimulates hypertrophy and contractility of neonatal rat cardiac myocytes in a serum‐free medium (1990)

The effect of endothelin (ET) on rat cardiac myocytes cultured in a serum-free, defined medium was determined. ET simulated cardiac myocyte hypertrophy in a dose-dependent manner as determined by the protein synthesis and cell surface area. Since the myocyte hypertrophy was abolished by H-7, a protein kinase C inhibitor, ET-receptor mediated protein kinase C activation may be involved in cardiac myocyte hypertrophy. At the same time, ET also stimulated myocyte contractility in this medium, and this stimulatory effect was inhibited by nicardipine. This result indicates that the influx of extracellular calcium ion is necessary for the stimulation of contractility induced by ET.