gebhart/patrepeval huggingface dataset:
The role of the resident microflora in the pathogenesis of dandruff (1989)

Current thinking implicates P. ovale as the cause of dandruff; the condition invariably resolves when this yeast is suppressed. However, P. acnes and coagulase-negative cocci are also abundant on the scalp. A contributory role for those members of the resident microflora has not been ruled out. We used a new technique to collect and weigh scales. We have determined the percentage of nucleated cells in scales, a measure of inflammation. The density of P. acnes, P. ovale and cocci were followed during and after treatment with antibacterial solutions and two anti-fungal shampoos, Octopirox © and Magnesium Oma-dine ©. The level of dandruff could not be correlated with changes in the numbers of aerobic and anaerobic bacteria. We concluded that resident bacteria probably play no role in the etiology of dandruff. Octopirox ©shampoo was more efficacious than Magnesium Omadine © in reducing scaling and P. ovale. While P. ovale is necessary, Koch&amp;apos;s postulates have not been fulfilled. The cause(s) of drandruff is (are) still unknown.
Dynamic particle-shape measurements using a near-field optical sensor (2003)

In this paper dynamic particle-shape measurements are presented using a near-field optical sensor. The sensor consists of two elongated photodiodes that are illuminated from the top. When a particles moves over the sensor it will partially block the light, which results in a drop of photocurrent proportional to the width of the particle. We have performed measurements using irregularly shaped PVC test particles having a diameter of 30-80 microns. The measurements prove that accurate size and shape information is obtained under the conditions that are found in a cytometer.
Determination of RNA-protein contacts using thiophosphate substitutions (1989)

The binding of the bacteriophage R17 coat protein to its RNA binding site is an example of a specific RNA-protein interaction. Extensive analysis has revealed that the binding is dependent upon a unique hairpin structure that contains four essential single-stranded nucleotides. Additional specificity is thought to be due to four or five ionic contacts between the protein and phosphates on the RNA. Transcription of synthetic DNA with T7 RNA polymerase, using one of the nucleoside 5'-O-(1-thiotriphosphates) [NTP(alpha S)s], allows the synthesis of RNAs specifically substituted with thiophosphates. Eleven sequence variants of the R17 coat protein binding site were synthesized with different NTP(alpha S)s and tested for coat protein binding to deduce positions of thiophosphates that alter the binding affinity. Of the twenty-one phosphate positions in the molecule, two were found to decrease the Ka 3-fold when substituted with a thiophosphate, one position decreased the Ka 10-fold, and one position increased the Ka 10-fold. Substitution of any of the other 17 positions with thiophosphates does not alter the Ka. The four positions that alter the Ka are located in a uniquely structured region of the RNA, and it is postulated that these thiophosphates affect binding because they contact coat protein directly.
CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2 (2013)

Coordinate overexpression of CXCL9, CXCL10, CXCL11, and CCL5 in pretreatment tumours was associated with responsiveness to treatment. Conversely, CCR5-Δ32 polymorphism and CXCR3/CCR5 underexpression influence downregulation of the corresponding receptors in TILs and were associated with likelihood and degree of response.
Simplification envelopes (1996)

We propose the idea of simplification envelopes for generating a hierarchy of level-of-detail approximations for a given polygonal model. Our approach guarantees that all points of an approximation are within a user-specifiable distance from the original model and that all points of the original model are within a distance from the approximation. Simplification envelopes provide a general framework within which a large collection of existing simplification algorithms can run. We demonstrate this technique in conjunction with two algorithms, one local, the other global.
Human Liver-Alcohol Dehydrogenase. Kinetic and Physicochemical Properties* (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHuman Liver-Alcohol Dehydrogenase. Kinetic and Physicochemical Properties*Jean-Pierre von Wartburg, J. L. Bethune, and Bert L. ValleeCite this: Biochemistry 1964, 3, 11, 1775–1782Publication Date (Print):November 1, 1964Publication History Published online1 May 2002Published inissue 1 November 1964https://pubs.acs.org/doi/10.1021/bi00899a033https://doi.org/10.1021/bi00899a033research-articleACS PublicationsRequest reuse permissionsArticle Views1025Altmetric-Citations154LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Amphiregulin Contributes to the Transformed Phenotype of Human Hepatocellular Carcinoma Cells (2006)

Hepatocellular carcinoma is a major cause of cancer-related deaths. Current treatments are not effective, and the identification of relevant pathways and novel therapeutic targets are much needed. Increasing evidences point to the activation of the epidermal growth factor receptor (EGFR) as an important mechanism in the development of hepatocarcinoma. We previously described that amphiregulin (AR), a ligand of the EGFR, is not expressed in healthy liver but is up-regulated during chronic liver injury, the background on which most liver tumors develop. Now, we have studied the expression and role of AR in human hepatocarcinoma. AR expression and function was studied in human liver tumors and cell lines. AR is expressed in human hepatocellular carcinoma tissues and cell lines and behaves as a mitogenic and antiapoptotic growth factor for hepatocarcinoma cells. We provide several lines of evidence, including AR silencing by small interfering RNAs and inhibition of amphiregulin by neutralizing antibodies, showing the existence of an AR-mediated autocrine loop that contributes to the transformed phenotype. Indeed, interference with endogenous AR production resulted in reduced constitutive EGFR signaling, inhibition of cell proliferation, anchorage-independent growth, and enhanced apoptosis. Moreover, knockdown of AR potentiated transforming growth factor-beta and doxorubicin-induced apoptosis. Conversely, overexpression of AR in SK-Hep1 cells enhanced their proliferation rate, anchorage-independent growth, drug resistance, and in vivo tumorigenic potential. These observations suggest that AR is involved in the acquisition of neoplastic traits in the liver and thus constitutes a novel therapeutic target in human hepatocarcinoma.
A Prospective Clinical Evaluation of Autogenous Vein Grafts Used as a Nerve Conduit for Distal Sensory Nerve Defects of 3 cm or Less (1990)

The purpose of this study was to determine the efficacy of autogenous vein grafts as nerve grafts (AVNC) for bridging of small peripheral sensory nerve gaps as compared with direct repair and with conventional nerve grafting techniques (ANG). Patients with painful neuroma or segmental nerve injury of 3 cm were chosen as the test group. Those amenable to direct repair were classified as controls. Between 1982 to 1988, a total of 22 patients were enrolled in this study. A total of 34 nerves were repaired, 15 with a venous nerve conduit, 4 with a sural nerve graft, and 15 with direct repair. Significant symptom relief and satisfactory sensory function return were uniformly observed. The two-point discrimination measurements indicated superiority of direct repair and probably of conventional nerve grafting. However, the universally favorable patient acceptance and the return of measurable two-point discrimination indicates the effectiveness of autogenous vein grafts as nerve conduits when selectively applied to bridge a small nerve gap (less than or equal to 3 cm) on nonessential peripheral sensory nerves.
Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016)

Recent advancements in single-cell and single-molecule imaging technologies have resolved biological processes in time and space that are fundamental to understanding the regulation of gene expression. Observations of single-molecule events in their cellular context have revealed highly dynamic aspects of transcriptional and post-transcriptional control in eukaryotic cells. This approach can relate transcription with mRNA abundance and lifetimes. Another key aspect of single-cell analysis is the cell-to-cell variability among populations of cells. Definition of heterogeneity has revealed stochastic processes, determined characteristics of under-represented cell types or transitional states, and integrated cellular behaviors in the context of multicellular organisms. In this review, we discuss novel aspects of gene expression of eukaryotic cells and multicellular organisms revealed by the latest advances in single-cell and single-molecule imaging technology.
Pollen allergen homologues in barley and other crop species (1995)

Pollen from 10 agricultural plant species was surveyed for the presence of proteins crossreactive with group I, group IV and group IX allergens. Barley (Hordeum vulgare), maize (Zea mays), rye (Secale cerale), triticale (xTriticosecale cereale), oats (Avena sativa), Canola (Brassica napus) and sunflower (Helianthus annus) pollens contained numerous allergen cognate proteins. Northern blot analysis of barley pollen RNA revealed the presence of group I and group IX allergen transcripts. The barley pollen cDNA hvp9742, and three other cloned allergens: phlenum protense (Phl p) V, Phl p Va and Lolium perenne (Lol p) 1b, were demonstrated to have extensive nucleotide and amino acid sequence similarity to the Poa p IX isoallergens. It was concluded that hvp9742 represents a Poa p IX isoallergen homologue expressed by barley pollen, and was therefore designated Hor v IX. It is further shown that the most highly conserved domains of all seven proteins, including Hor v IX, map to previously defined Poa p IX antibody binding epitopes.
Design and Characterization of a Soft Multi-Axis Force Sensor Using Embedded Microfluidic Channels (2013)

Thin, highly compliant sensing skins could provide valuable information for a host of grasping and locomotion tasks with minimal impact on the host system. We describe the design, fabrication, and characterization of a novel soft multi-axis force sensor made of highly deformable materials. The sensor is capable of measuring normal and in-plane shear forces. This soft sensor is composed of an elastomer (modulus: 69 kPa) with embedded microchannels filled with a conductive liquid. Depending on the magnitude and the direction of an applied force, all or part of the microchannels will be compressed, changing their electrical resistance. The two designs presented in this paper differ in their flexibility and channel configurations. The channel dimensions are approximately 200 × 200 μm and 300 × 700 μm for the two prototypes, respectively. The overall size of each sensor is 50 × 60 × 7 mm. The first prototype demonstrated force sensitivities along the two principal in-plane axes of 37.0 and -28.6 mV/N. The second prototype demonstrated the capability to detecting and differentiating normal and in-plane forces. In addition, this paper presents the results of a parameter study for different design configurations.
TB: a clinical manual for South East Asia. (1997)

This manual is mainly for doctors and other health professionals who work in public or private health centres and hospitals in high tuberculosis prevalence countries where the problem of TB/HIV is also increasing. Health care facilities vary from place to place. In this manual we assume your health care set-up has access to a small laboratory and X-ray service. Even if you do not have these facilities we hope that the manual will still be useful. Health professionals who care for tuberculosis patients now need to know how to diagnose and treat tuberculosis and other HIV-related diseases. This manual will help you in this task. This pocket manual is so designed that you can use it on the ward in the clinic and at home. There is not enough room in a pocket manual for all the possible information you may want to know about TB and TB/HIV. So at the end of each chapter there are suggestions for further reading. These suggestions include relevant books background material reviews and recent articles in journals. (excerpt)
Comparative Aspects of Osteosarcoma (1991)

Canine osteosarcoma bears striking resemblance to osteosarcoma in humans. Similarities include the following: male sex predilection, large patient size, 75% or more affecting the appendicular site, metaphyseal location, generally unknown etiology, less than 10% of patients have documented metastasis at presentation, over 90% of tumors show high-grade histology, 75% of tumors show aneuploidy, the metastatic rate is 80% or more with amputation alone, the lung is the most common site of metastasis, and there is improved survival with adjuvant chemotherapy. The major differences are age of onset, with dogs being affected in middle age; greater frequency in the dog, with over 8000 new cases per year; and time to metastasis being faster in the dog than man. Canine osteosarcoma is a readily available and highly comparable spontaneously occurring cancer that should be useful in a better understanding of the same disease in humans.
Coordinated downlink multi-point communications in heterogeneous cellular networks (2012)

In this paper we assess how coordination among base stations can be exploited to improve downlink capacity in fourth generation (4G) cellular networks. We focus on heterogeneous networks where low-power pico cells are deployed within the coverage area of an existing macro network with the aim of offloading traffic from the (potentially congested) macro cells to low-power cells. Firstly, we describe an enhanced inter-cell interference coordination scheme which is shown to achieve a significant capacity gain in such deployments by leveraging a loose coordination among neighbor base stations. Secondly, we explore how a tighter coordination among base stations can be exploited to further improve the network capacity. Even though the schemes described in this paper apply to long term evolution (LTE) wireless networks, we point out that most of the findings and conclusions we draw apply to any cellular network.
Detecting highly entangled states with a joint qubit readout (2010)

A single-channel joint readout is used to analyze highly entangled two-qubit states in a circuit quantum electrodynamics architecture. The measurement model for the readout is fully characterized, demonstrating a large sensitivity to two-qubit correlations. We quantify the high degree of entanglement by measuring a violation of the Clauser-Horne-Shimony-Holt inequality with a value of $2.61\ifmmode\pm\else\textpm\fi{}0.04$, without optimizing the preparation of the two-qubit state. In its present form, this joint readout can resolve improvements to the fidelity of two-qubit operations and be extended to three or four qubits.
Mab-Zap: A Tool for Evaluating Antibody Efficacy for Use in an Immunotoxin (2000)

Immunotoxins, consisting of antibodies coupled to toxins, are extremely useful tools in the elimination of specific cell populations in vitro and in vivo for research and therapeutic applications. The antibody is used to target the toxin to a specific cell population, which is distinguished by its cell-surface antigen. Not all antibodies are suitable for creating an immunotoxin, and large numbers of antibodies may need to be screened. This is a time-consuming and expensive process if each potential candidate must be conjugated to the toxin and purified. A faster and more economical way to identify potential targeting antibodies is to use a second immunotoxin, an anti-IgG antibody that is coupled to the toxin. The second immunotoxin eliminates the need to couple every candidate antibody to the toxin because it can simply be added to cells in culture with the antibody of interest. Using this method, many antibodies can be screened quickly and efficiently for their ability to internalize.
Clinical implications of coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine leiomyoma (2003)

The expression of Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, and the receptor tyrosine kinases Axl and Sky and their mRNAs in uterine leiomyoma and normal uterine myometrium tissues were investigated by competitive RT-PCR-Southern blot analysis using recombinant RNA and immuno histochemical analysis respectively. There was no significant difference between the histoscores and levels of Sky mRNA in uterine leiomyoma and normal uterine myometrium, although the levels of Gas6 and Axl mRNAs in uterine leiomyoma were significantly higher than in normal uterine myometrium in each case. It is suggested that Gas6 and Axl signal transduction is aberrantly stimulated in uterine leiomyoma, possibly related to its growth.
Activated Carbon Aerogels (1996)

Activated carbon aerogels were obtained from the CO2 activation of carbon aerogels. The adsorption isotherms of nitrogen on activated carbon aerogels at 77 K were measured and analyzed by the high-resolution αS plot to evaluate their porosities. The αS plot showed an upward deviation from linearity below αS = 0.5, suggesting that the presence of micropores becomes more predominant with the extent of the activation. Activation increased noticeably the pore volume and the surface area (the maximum value: 2600 m2·g-1) without change of the basic network structure of primary particles. Activated carbon aerogels had a bimodal pore size distribution of uniform micropores and mesopores.
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens (2002)

The biallelic platelet-specific Gov antigen system-implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura-is carried by the glycosylphosphatidylinositol (GPI)-linked protein CD109. The recent identification of the human CD109 complementary DNA (cDNA) has allowed the molecular nature of the Gov alleles to be elucidated. By using reverse transcriptase-polymerase chain reaction (RT-PCR) to amplify CD109 cDNAs from 6 phenotypically homozygous Gov(aa) and Gov(bb) individuals, we have determined that the Gov alleles differ by an A to C single nucleotide polymorphism (SNP) at position 2108 of the coding region, resulting in a Tyr/Ser substitution at CD109 amino acid 703. Allele-specific PCR sequence-specific primers (SSP), PCR-restriction fragment length polymorphism, and real-time PCR studies of 15 additional donors (5 Gov(aa), 5 Gov(bb), and 5 Gov(ab)) confirmed that this SNP correlates with the Gov phenotype. In addition, Chinese hamster ovary cells transiently expressing nucleotide 2108 A>C CD109 cDNA variants were recognized specifically by allele-specific Gov antisera, indicating that this polymorphism defines the Gov alloantigenic determinants. Real-time PCR was then used to genotype 85 additional Gov phenotyped donors. In all but 3 cases, genomic testing concurred with the Gov phenotype. Repeat testing corrected 2 of these discrepancies in favor of the genotyping result. The third discrepancy could not be resolved, likely reflecting low-level CD109 expression below the sensitivity of the phenotyping assay. We conclude that the Gov alleles are defined by a 2108 A>C SNP that results in a Tyr703Ser substitution of CD109 and that genotyping studies are more accurate for Gov alloantigen determination than are conventional serologic methods.
Analgesic effect of somatostatin analogue (octreotide) in headache associated with pituitary tumours. (1987)

The COVID19 pandemic, caused by SARS-CoV-2, has infected more than 100 million people worldwide. Due to the rapid spreading of SARS-CoV-2 and its impact, it is paramount to find effective treatments against it. Human neutralizing antibodies are an effective method to fight viral infection. However, the recent discovery of new strains that substantially change the S-protein sequence has raised concern about vaccines and antibodies’ effectiveness. Here, we investigated the binding mechanisms between the S-protein and several antibodies. Multiple mutations were included to understand the strategies for antibody escape in new variants. We found that the combination of mutations K417N and E484K produced higher binding energy to ACE2 than the wild type, suggesting higher efficiency to enter host cells. The mutations’ effect depends on the antibody class. While Class I enhances the binding avidity in the presence of N501Y mutation, class II antibodies showed a sharp decline in the binding affinity. Our simulations suggest that Class I antibodies will remain effective against the new strains. In contrast, Class II antibodies will have less affinity to the S-protein, potentially affecting these antibodies’ efficiency.
Photophysical Properties and OLED Applications of Phosphorescent Platinum(II) Schiff Base Complexes (2009)

The syntheses, crystal structures, and detailed investigations of the photophysical properties of phosphorescent platinum(II) Schiff base complexes are presented. All of these complexes exhibit intense absorption bands with lambda(max) in the range 417-546 nm, which are assigned to states of metal-to-ligand charge-transfer ((1)MLCT) (1)[Pt(5d)-->pi*(Schiff base)] character mixed with (1)[lone pair(phenoxide)-->pi*(imine)] charge-transfer character. The platinum(II) Schiff base complexes are thermally stable, with decomposition temperatures up to 495 degrees C, and show emission lambda(max) at 541-649 nm in acetonitrile, with emission quantum yields up to 0.27. Measurements of the emission decay times in the temperature range from 130 to 1.5 K give total zero-field splitting parameters of the emitting triplet state of 14-28 cm(-1). High-performance yellow to red organic light-emitting devices (OLEDs) using these platinum(II) Schiff base complexes have been fabricated with the best efficiency up to 31 cd A(-1) and a device lifetime up to 77 000 h at 500 cd m(-2).
Cossack: coordinated suppression of simultaneous attacks (2004)

DDoS attacks are highly distributed, well coordinated, offensive assaults on services, hosts, and infrastructure of the Internet. Effective defensive countermeasures to DDoS attacks will require equally sophisticated, well coordinated, monitoring, analysis, and response. The Cossack project is developing an architecture to explore such coordination using multicast, annotated topology information, and novel blind detection techniques.