gebhart/patrepeval huggingface dataset:
Robust Radiometric Calibration and Vignetting Correction (2008)

In many computer vision systems, it is assumed that the image brightness of a point directly reflects the scene radiance of the point. However, the assumption does not hold in most cases due to nonlinear camera response function, exposure changes, and vignetting. The effects of these factors are most visible in image mosaics and textures of 3D models where colors look inconsistent and notable boundaries exist. In this paper, we propose a full radiometric calibration algorithm that includes robust estimation of the radiometric response function, exposures, and vignetting. By decoupling the effect of vignetting from the response function estimation, we approach each process in a manner that is robust to noise and outliers. We verify our algorithm with both synthetic and real data which shows significant improvement compared to existing methods. We apply our estimation results to radiometrically align images for seamless mosaics and 3D model textures. We also use our method to create high dynamic range (HDR) mosaics which are more representative of the scene than normal mosaics.
An overview of the PICASSO project research activities in speaker verification for telephone applications (1999)

The problem of labelling speaker turns by automatically segmenting and clustering a continuous audio stream is addressed.A new clustering scheme is presented and evaluated using a clustering efficiency score which treats both agglomerative and divisive clustering strategies equally.Results show an efficiency of 70% can be obtained on both manually and automatically derived segments on the 1996 Hub4 development data.For the task of identifying potentially unknown anchor speakers within broadcast news shows, the frame classification error rate is very important.To reflect this, a frame-based cluster efficiency is defined and the results show a 90% frame-based efficiency can be achieved.Finally a frame-based comparison between the manually and automatically derived segment/cluster sets shows that approximately one third of the errors are introduced during segmentation and two-thirds during clustering.
The mutationally activated Met receptor mediates motility and metastasis (1998)

Mutations in Met have been identified in human papillary renal carcinomas. We have shown previously that these mutations deregulate the enzymatic activity of Met and that NIH 3T3 cells expressing mutationally activated Met are transformed in vitro and are tumorigenic in vivo. In the present investigation, we find that mutant Met induces the motility of Madin-Darby canine kidney cells in vitro and experimental metastasis of NIH 3T3 cells in vivo, and that the Ras-Raf-MEK-ERK signaling pathway, which has been implicated previously in cellular motility and metastasis, is constitutively activated by the Met mutants. We also report that transgenic mice harboring mutationally activated Met develop metastatic mammary carcinoma. These data confirm the tumorigenic activity of mutant Met molecules and demonstrate their ability to induce the metastatic phenotype.
Progress in lithium polymer battery development for telecommunication system (2002)

This paper is the second of a series describing the development of a new battery technology for use as an energy storage system in telecommunications applications. The lithium polymer battery (LPB) promises to be the next generation power source. This paper describes the LPB energy storage system, including battery module thermal management and monitoring and control devices. Lab cells in the range of 7 Ah capacity and prototype battery modules of 24 V and 80 Ah capacity were built and tested. Also discussed is the battery module design flexibility which allows for various battery string configurations.
WIDER FACE: A Face Detection Benchmark (2015)

Face detection is one of the most studied topics in the computer vision community. Much of the progresses have been made by the availability of face detection benchmark datasets. We show that there is a gap between current face detection performance and the real world requirements. To facilitate future face detection research, we introduce the WIDER FACE dataset, which is 10 times larger than existing datasets. The dataset contains rich annotations, including occlusions, poses, event categories, and face bounding boxes. Faces in the proposed dataset are extremely challenging due to large variations in scale, pose and occlusion, as shown in Fig. 1. Furthermore, we show that WIDER FACE dataset is an effective training source for face detection. We benchmark several representative detection systems, providing an overview of state-of-the-art performance and propose a solution to deal with large scale variation. Finally, we discuss common failure cases that worth to be further investigated. Dataset can be downloaded at: mmlab.ie.cuhk.edu.hk/projects/WIDERFace
Conjugated Polymer-Based Organic Solar Cells (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConjugated Polymer-Based Organic Solar CellsSerap Günes, Helmut Neugebauer, and Niyazi Serdar SariciftciView Author Information Linz Institute of Organic Solar Cells (LIOS), Physical Chemistry, Johannes Kepler University of Linz, Austria Cite this: Chem. Rev. 2007, 107, 4, 1324–1338Publication Date (Web):April 11, 2007Publication History Received17 September 2006Published online11 April 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/cr050149zhttps://doi.org/10.1021/cr050149zresearch-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views66227Altmetric-Citations5692LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carrier dynamics,Electrical conductivity,Electrodes,Mobility,Solar cells Get e-Alerts
Cleavable Cross-Linker for Protein Structure Analysis: Reliable Identification of Cross-Linking Products by Tandem MS (2010)

Chemical cross-linking combined with a subsequent enzymatic cleavage of the created cross-linked complex and a mass spectrometric analysis of the resulting cross-linked peptide mixture presents an alternative approach to high-resolution analysis, such as NMR spectroscopy or X-ray crystallography, to obtain low-resolution protein structures and to gain insight into protein interfaces. Here, we describe a novel urea-based cross-linker, which allows distinguishing different cross-linking products by collision-induced dissociation (CID) tandem MS experiments based on characteristic product ions and constant neutral losses. The novel cross-linker is part of our ongoing efforts in developing collision-induced dissociative reagents that allow an efficient analysis of cross-linked proteins and protein complexes. Our innovative analytical concept is exemplified for the Munc13-1 peptide and the recombinantly expressed ligand binding domain of the peroxisome proliferator-activated receptor alpha, for which cross-linking reaction mixtures were analyzed both by offline nano-HPLC/MALDI-TOF/TOF mass spectrometry and by online nano-HPLC/nano-ESI-LTQ-orbitrap mass spectrometry. The characteristic fragment ion patterns of the novel cross-linker greatly simplify the identification of different cross-linked species, namely, modified peptides as well as intrapeptide and interpeptide cross-links, from complex mixtures and drastically reduce the potential of identifying false-positive cross-links. Our novel urea-based CID cleavable cross-linker is expected to be highly advantageous for analyzing protein 3D structures and protein-protein complexes in an automated manner.
Pet imaging of cytotoxic human T cells using an 89Zr-labeled anti-CD8 minibody (2015)

Meeting abstracts Major challenges to advancing the new wave of cancer immunotherapies are to select patients who will respond to single immunotherapies, identify those who need more tailored combination regimens, and then, determine early during treatment whether the therapy is working. “
Effect of sample filtration on the quality of monitoring data reported for organic compounds during wastewater treatment (2009)

Accurate quantification of organic wastewater compounds (OWCs) is essential for assessing their removal efficiency in wastewater treatment plants (WWTPs) and for calculating discharge rates into effluent-receiving surface waters. In this study, we undertook a theoretical evaluation of the effect of sorption and sample filtration on data quality. Filtration of samples, while commonly practiced, may preclude a potentially significant fraction of chemical mass from both chemical measurements and mass flow analyses for WWTPs. Sorption theory dictates that analyte losses from sample filtration are notable for hydrophobic organic compounds (HOCs) featuring a pH-dependent logarithmically transformed organic carbon-water distribution coefficient (log D(OC)) of > or =3.0. Among a total of 33 organic wastewater compounds considered, the extent of sorption to filterable materials ranged from 22% for bisphenol A diglycidyl ether (BADGE) to 99% for di-(2-ethylhexyl)phthalate (DEHP). Sample filtration also was demonstrated to have a profound impact on the outcome of chemical fate and behavior studies. When the chemical mass residing on filterable particulates was considered, the concentration spread (range) doubled between maximum and minimum concentrations reported for raw wastewater. Furthermore, removal efficiencies of WWTPs calculated for HOCs increased by as much as 62% just by changing the method of accounting. We conclude that some of the data spread reported in the literature concerning chemical mass loadings, contaminant concentrations in raw sewage, and removal efficiencies of similarly designed WWTPs is driven not by actual differences in sewage composition, geographic locations and treatment units but by sample processing protocols and the method of mass accounting.
Probiotics in man and animals. (1989)

There is good evidence that the complex microbial flora present in the gastrointestinal tract of all warm-blooded animals is effective in providing resistance to disease. However, the composition of this protective flora can be altered by dietary and environmental influences, making the host animal susceptible to disease and/or reducing its efficiency of food utilization. What we are doing with the probiotic treatments is re-establishing the natural condition which exists in the wild animal but which has been disrupted by modern trends in conditions used for rearing young animals, including human babies, and in modern approaches to nutrition and disease therapy. These are all areas where the gut flora can be altered for the worse and where, by the administration of probiotics, the natural balance of the gut microflora can be restored and the animal returned to its normal nutrition, growth and health status.
Vision based human activity tracking using artificial neural networks (2010)

The tracking and understanding the behavior of human beings is an important problem in a number of industrial applications. At the highest level, the system capable of resolving this problem should be able to recognize the human behavior and understand the intent and motive from the observation alone. This is a difficult task, even for humans to perform, and the mistakes and misinterpretations are very common. In this text, a method for the design of an artificial neural network based intelligent human activity monitoring system is proposed, that can detect and track suspicious activity in a typical surveillance environment. This method makes use of the silhouette pattern of the human blob obtained from segmentation of the scene captured by the camera.
Stoichiometry of O2 metabolism and NADPH oxidation of the cell-free latent oxidase reconstituted from cytosol and solubilized membrane from resting human neutrophils. (1993)

The stoichiometry of NADPH-dependent O2 consumption expressed by reconstituted latent oxidase obtained by combining cytosol and membrane fractions from resting human neutrophils with GTP gamma S and SDS in a cell-free assay was evaluated with regard to NADPH consumed and superoxide and H2O2 production. Oxidase activity monitored simultaneously by O2 uptake analysis using a Clark cell and O2 electrode for O2 consumption, and spectrally at 340 nm for NADPH oxidation, in the presence of excess superoxide dismutase and catalase, yielded an O2 uptake: NADPH consumption ratio of 0.51 +/- 0.04 (+/- 1 S.D., n = 6). In the presence of varying concentrations of ferricytochrome c in excess of 100 microM, and with exclusion of superoxide dismutase, the net rate of O2 consumption plateaued at approximately 6% of the rate seen with exclusion of ferricytochrome c from final assay mixtures. Cytosol and solubilized membrane fractions employed in these assays were devoid of endogenous superoxide trapping, or dismutase-like, activities. These results indicate that of the total O2 consumed, 94% is associated with direct univalent generation of superoxide. The remaining albeit low level of O2 consumption appears to be recovered in the form of H2O2 indicating that the cell-free oxidase reconstituted with SDS is capable of channeling electron equivalents through its redox sites in a highly controlled manner in ensuring that superoxide is its principal O2 reduction product concomitant with oxidation of NADPH.
Encryption System Integrated with ROI and Tracking for High Efficiency Video Coding (2014)

In this paper, we present a novel encryption scheme that integrates Region of Interest (ROI) tracking on the next generation High Efficiency Video Coding (HEVC) standard. With the Tracking Learning Detection (TLD) algorithm, the ROI encryption system can become more intelligent through constrained motion estimation and some constrained mode decision. The encryption system we proposed on the selected bin strings in Context Adaptive Binary Arithmetic Coding (CABAC) of the HEVC can achieve an obvious encryption performance improvement on different situations. With the RSA and key management scheme, the security of our encryption system is fully guaranteed.
New type of antibody-enzyme conjugate which specifically kills Candida albicans (1980)

A new type of antibody-enzyme conjugate was made, and its possible application to Candida infection was studied. Both lactoperoxidase and xanthine oxidase were conjugated to specific antibody against Candida albicans. In vitro microbiocidal activity of the new antibody-enzyme conjugate, when incubated together with xanthine and minute amount of halides, showed a remarkable level of candidacidal ability. When the new antibody-enzyme conjugate was given to Candida-infected mice, followed by injecting xanthine and a minute amount of halides, about 50% of these heavily infected mice survived, whereas all control nontreated mice died. These data suggest that the further eleboration of this new antibody-enzyme conjugate might lead us to improve our therapeutic methods of clinical medicine.
Correlated color temperature? (1977)

Color temperatures of sources that do not match a blackbody at any temperature are determined by use of “isotemperature” lines drawn in some chromaticity diagram. Those lines were derived from conjectures, not from any observational data. The only known observational data of the kind are at least 35 years old, but are published here for the first time. Recent CIE recommendation of two new color-difference formulas implies that the isotemperature lines should be correspondingly changed. The changes indicate that color temperatures of some common light sources should be several hundred degrees different than their present ratings. Observations are advocated, to determine whether those changes are appropriate.
Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease. (1998)

Respiratory syncytial virus (RSV) is a frequent cause of severe lung disease in young children. Primed T cells are required for virus clearance, but are causally implicated in the enhanced pathology seen following RSV infection of some infants and experimental animals vaccinated against the virus. In BALB/c mice, vaccination with recombinant vaccinia virus expressing the viral attachment protein (G) leads to pulmonary eosinophilia during subsequent infection, which indirect evidence suggests may be due to CD4+ Th2 cells. The production of IFN-gamma, IL-2, -4, -5 and -10 cytokine mRNA by RT-PCR and intracellular cytokines by flow cytometry following RSV challenge of vaccinated mice were therefore compared. Lung eosinophilia was associated with enhanced local recruitment of CD4+ cells in G sensitized mice, while CD8+ cells dominated in mice vaccinated with the viral fusion protein (F) or second matrix protein (M2). Lung eosinophilia was also associated with a localized reduction in IFN-gamma and increased IL-4 and IL-5 mRNA transcription as well as elevated RSV specific IgG1 antibody production. Th2 cytokine protein production by T cells showed no apparent change. Although IFN-gamma production diminished in eosinophilic mice, it remained the major cytokine found in lung T cells. It was concluded that lung eosinophilia can develop despite abundant IFN-gamma production by local T cells, but is associated with a shift in the balance between Th2 and Th1 cytokine production.
In Vitro Bactericidal Capacity of Human Polymorphonuclear Leukocytes: Diminished Activity in Chronic Granulomatous Disease of Childhood * (1967)

Diminished bactericidal capacity was found to be characteristic of polymorphonuclear leukocytes (PMN) from five children with the clinical syndrome of granulomatous disease of childhood. The PMN from these children demonstrated nearly normal phagocytic capacity, and the majority of viable bacteria, after 2 hours of incubation in the phagocytosis system, were found associated with leukocytes. The morphology of the unstimulated polymorphonuclear leukocytes from patients with chronic granulomatous disease was similar to those from normal persons of similar ages by light and electron microscopy. In addition, the total lysozyme and phagocytin activity of leukocyte extracts from these patients was similar to those from equal numbers of leukocytes from controls.A striking difference in the cytoplasmic response after phagocytosis characterized the PMN of the patients with granulomatous disease. Whereas degranulation, vacuole formation, and rapid bacterial digestion were the rule in the PMN from controls, little degranulation and persistence of intact bacteria in the cytoplasm characterized disease. The deficiency of bactericidal capacity and the minimal degranulation after active phagocytosis by the PMN of these children with an inherited syndrome suggest that separate metabolic processes are involved in phagocytosis and in intracellular digestion. Continuing study of the metabolic function of leukocytes from these children should provide an opportunity for increased understanding of the metabolic basis for degranulation and intracellular digestion in phagocytic cells.
Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (II) (2013)

Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major problem, causing severe and intractable infections worldwide. MRSA is resistant to all beta-lactam antibiotics, and alternative treatments are limited. A very limited number of new antibiotics have been discovered over the last half-century, novel agents for the treatment of MRSA infections are urgently needed. Marinopyrrole A was reported to show antibiotic activity against MRSA in 2008. After we reported the first total synthesis of (±)-marinopyrrole A, we designed and synthesized a series of marinopyrrole derivatives. Our structure activity relationship (SAR) studies of these novel derivatives against a panel of Gram-positive pathogens in antibacterial assays have revealed that a para-trifluoromethyl analog (33) of marinopyrrole A is ≥ 63-, 8-, and 4-fold more potent than vancomycin against methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA, respectively. The results provide valuable information in the search for new-generation antibiotics.
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints (2016)

Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune microenvironment in the context of anti-PD-1 therapy in two fully immunocompetent mouse models of lung adenocarcinoma. In tumours progressing following response to anti-PD-1 therapy, we observe upregulation of alternative immune checkpoints, notably T-cell immunoglobulin mucin-3 (TIM-3), in PD-1 antibody bound T cells and demonstrate a survival advantage with addition of a TIM-3 blocking antibody following failure of PD-1 blockade. Two patients who developed adaptive resistance to anti-PD-1 treatment also show a similar TIM-3 upregulation in blocking antibody-bound T cells at treatment failure. These data suggest that upregulation of TIM-3 and other immune checkpoints may be targetable biomarkers associated with adaptive resistance to PD-1 blockade.
Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes (2001)

'Nomenclature of the Human Immunoglobulin Heavy (IGH) Genes', the 16th report of the 'IMGT Locus in Focus' section, provides the first complete list of all the human IGH genes. The total number of human IGH genes per haploid genome is 170-176 (206-212 genes, if the orphons and the processed gene are included), of which 77-84 genes are functional. IMGT/Human Genome Organization (HUGO) gene names and definitions of the human IGH genes on chromosome 14q32.33, processed gene on chromosome 9 and IGH orphons on chromosomes 15 and 16 are provided with the gene functionality and the number of alleles, according to the rules of the IMGT Scientific chart, with the accession numbers of the IMGT reference sequences and with the accession ID of the Genome Database GDB and NCBI LocusLink databases, in which all the IMGT human IGH genes have been entered. The tables are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France.