gebhart/patrepeval huggingface dataset:
Blind Subband Beamforming With Time-Delay Constraints for Moving Source Speech Enhancement (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A new robust microphone array method to enhance speech signals generated by a moving person in a noisy environment is presented. This blind approach is based on a two-stage scheme. First, a subband time-delay estimation method is used to localize the dominant speech source. The second stage involves speech enhancement, based on the acquired spatial information, by means of a soft-constrained subband beamformer. The novelty of the proposed method involves considering the spatial spreading of the sound source as equivalent to a time-delay spreading, thus, allowing for the estimated intersensor time-delays to be directly used in the beamforming operations. In comparison to previous approaches, this new method requires no special array geometry, knowledge of the array manifold, or acquisition of calibration data to adapt the array weights. Furthermore, such a scheme allows for the beamformer to efficiently adapt to speaker movement. The robustness of the time-delay estimation of speech signals in high noise levels is improved by making use of the non-Gaussian nature of speech trough a subband Kurtosis-weighted structure. Evaluation in a real environment with a moving speaker shows promising results, with suppression levels of up to 16 dB for background noise and interfering (speech) signals, associated to a relatively small effect of speech distortion. </para>
In vivo study of the GC90/IRIV vaccine for immune response and autoimmunity into a novel humanised transgenic mouse (2003)

Parathyroid hormone-related protein (PTH-rP), a secreted protein produced by prostate carcinoma and other epithelial cancers, is considered a key agent for the development of bone metastases. We investigated the construct GC90/IRIV, composed of immunopotentiating reconstituted influenza virosomes (IRIV) containing PTH-rP gene plasmids (GC90), as a potential tool for human anticancer immunotherapy into humanised mice transgenic for HLA-A(*)02.01, the human-beta2 microglobulin, and the human CD8alpha molecule. Intranasal administration of GC90/IRIV resulted in the induction of a PTH-rP-specific multiepitope cytotoxic T-cell (CTL) response. Cytotoxic T cells derived from vaccinated mice were capable of lysing in vitro syngenic murine PTH-rP transfectants and human HLA-A((*))02.01(+)/PTH-rP(+) prostate carcinoma LNCaP cells as well. The immune response capacity and the absence of any sign of toxicity and/or autoimmunity in vivo suggest the GC90/IRIV vaccine as a valid tool for active specific immunotherapy of human cancers and metastases overexpressing PTH-rP.
Treatment of Shock with Dextrans and Gelatins (1969)

Summary. The effects and side effects of dextran and gelatin plasma substitutes relevant to the treatment of shock are reviewed. The physico‐chemical characteristics give the dextrans a certain lead over the gelatins with respect to molecular weight, intravascular volume effect and retention period. Experimental studies and clinical experience, however, have failed to demonstrate any difference of their therapeutic value, as revealed by survival data and suppression of shock‐induced metabolic alterations. Severe allergic reactions may occur with dextrans, but have not so far been recorded with gelatins. Hemostatic impairment limits the tolerated dose of clinical dextran, the risk of renal damage that of low molecular weight dextran. Similar side effects of the gelatins have not been documented. The risk of overtransfusion is greater with dextrans than with gelatins. The lower potency of the gelatins would appear, therefore, to be at least outweighed by their freedom from side effects, which enlarges the therapeutic margin of safety for shock treatment with artificial colloids.
<title>OS/2 Resource Reservation System</title> (1995)

The OS/2 Resource Reservation System supports bandwidth reservation in the LAN Server Ultimedia multimedia file server. This paper describes how audio/video streams are specified and managed by the resource reservation system. The problem of variable-bit-rate stream utilization is considered: It is shown that the peak-rate of the variable-bit-rate stream can be reduced as the size of the destination buffer is increased beyond a single block. A buffered-peak-rate descriptor is presented that computes peak rate of variable-bit-rate stream based upon a particular client-buffer size. The framework and interfaces of the resource reservation system are described.
Pharmacokinetics and biotransformation studies of terfenadine in man. (1982)

Comparison of plasma level data obtained from a dose-response study to that of a 14C material balance study indicates that 99.48% of the alpha-[4-(1,1-dimethylethyl)phenyl] 4-(hydroxydiphenylmethyl)-1-piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.) related material absorbed undergoes biotransformation. From the balance study it has been determined that fecal excretion accounts for ca. 60% of the dose administered. Thin-layer chromatographic analysis of urine and feces revealed the presence of two major metabolic products. These compounds have been isolated and their structures determined by GC-MS. One of the metabolic products, a carboxylic acid analog of terfenadine has been shown to have antihistaminic activity and may play a role in the activity of the parent drug in vivo.
Binding of Monoiodinated Neuropeptide Y to Hippocampal Membranes and Human Neuroblastoma Cell Lines (1989)

Monoiodinated radioligands of the homologous 36-amino acid peptides, neuropeptide Y (NPY) and peptide YY, were prepared by reverse phase high performance liquid chromatography with isocratic elution. [125I-Tyr1]- and [125I-Tyr36]monoiodoNPY bound equally well to a single class of high affinity binding sites on synaptosomal membranes prepared from porcine hippocampus (Kd = 1.0 X 10(-10) M) whereas iodine substitution in Tyr27, for example, partly interfered with the receptor binding. The receptors on the hippocampal membranes did not distinguish between neuropeptide Y and peptide YY either in their monoiodinated or in their unlabeled forms. Six out of twelve human neuroblastoma cell lines had high affinity binding sites for monoiodinated NPY ranging from 2 to 145 X 10(3) sites per cell. The NPY binding to three of the cell lines, SMS-MSN, SMS-KAN, and CHP-234 was of relatively high affinity (Kd = 1.3 to 6.1 X 10(-10) M), and, as in the hippocampal membranes, the long C-terminal fragment, NPY(13-36)peptide was also a relatively potent ligand for these receptors. Two other neuroblastoma cell lines, MC-IXC and CHP-212, expressed NPY receptors characterized by a lower affinity (Kd = 4.8 and 24.6 X 10(-9) M) and negligible cross-reactivity with the C-terminal fragment. It is concluded that monoiodinated radioligands of the tyrosine-rich neuropeptide Y can be prepared and that receptors for these ligands in two apparently different subtypes are found on a series of human neuroblastoma cell lines.
Procedure for Rapid Fabrication of Non-Assembly Mechanisms With Embedded Components (2002)

In this paper, the application of Rapid Prototyping in fabricating non-assembly robotic systems and mechanisms with inserts is presented. Previous work demonstrated the use of the Rapid Prototype Stereolithography and Selective Laser Sintering techniques to fabricate prototypes of mechanical mobile joints. As examples of their applicability, the joint designs were then used to fabricate complex multi-articulated, multi-link, multi-loop systems in one step, without requiring assembly while maintaining the joint desired mobility. Expanding upon this, current research explores methods of insertion of component parts during the rapid prototype process. A rapidly prototyped mobile vehicle, RP MOVe, was fabricated to show this method and is presented here.
Proximity between nucleotide/dinucleotide and metal ion binding sites in DNA-dependent RNA polymerase from Escherichia coli (1992)

In order to understand translocation in transcription, it is important to develop a continuous functional assay for RNA polymerase (RNAP) activity in vitro. Fluorescent derivatives of ATP, UTP, UpA, and CpA with aminonaphthalene-5-sulfonic acid (AmNS) attached to the nucleotide triphosphates via a gamma-phosphoramidate bond or to the dinucleotide monophosphates via a 5'-secondary amine linkage were synthesized [Tyagi, S.C., & Wu, F.Y.-H. (1987) J. Biol. Chem. 262, 10684-10688]. The fluorescent emission spectra of (5'-AmNS)UpA, (5'-AmNS)CpA, (gamma-AmNS)ATP, and (gamma-AmNS)UTP overlap the absorption spectrum of co-substituted RNA polymerase (Co-RNAP) and ensure fluorescence resonance energy transfer (FRET) between the fluorescent analog and Co(II) in Co-RNAP. The binding constants at a single site for (gamma-AmNS)ATP, (gamma-AmNS)UTP, (5'-AmNS)UpA, and (5'-AmNS)CpA were observed to be 7.11, 5.26, 0.52, and 0.61 microM, respectively, in Co-RNAP and 5.70, 3.42, 0.12, and 0.21 microM, respectively, in Zn-RNAP. (8-AmTEMPO)ATP, with the spin probe AmTEMPO attached to the C-8 position at ATP [Tyagi, S.C. (1991) J. Biol. Chem. 266, 17936-17940], and Mn(3'-OCH3)UTP were synthesized. Mn-(II)-substituted RNA polymerase (Mn-RNAP) is prepared. The single site binding constants for (8-Am-TEMPO)ATP and Mn(3'-OCH3)UTP were 3.58 and 2.35 microM in Zn-RNAP and 5.77 and 3.43 microM in Mn-RNAP, respectively. These results indicate that dinucleotides bind much more tightly than mononucleotides to RNAP and that the binding constants are roughly the same for both Co- and Zn-substituted RNAP.(ABSTRACT TRUNCATED AT 250 WORDS)
Undecylenic Acid Inhibits Morphogenesis of Candida albicans (2000)

Resilient liners are frequently used to treat denture stomatitis, a condition often associated with Candida albicans infections. Of 10 liners tested, 2 were found to inhibit the switch from the yeast form to hyphae and a third was found to stimulate this switch. The inhibitor was determined to be undecylenic acid.
Covalent Attachment of Lipid Vesicles to a Fluid-Supported Bilayer Allows Observation of DNA-Mediated Vesicle Interactions (2010)

Specific membrane interactions such as lipid vesicle docking and fusion can be mediated by synthetic DNA-lipid conjugates as a model for the protein-driven processes that are ubiquitous in biological systems. Here we present a method of tethering vesicles to a supported lipid bilayer that allows the simultaneous deposition of cognate vesicle partners displaying complementary DNA, resulting in well-mixed populations of tethered vesicles that are laterally mobile. Vesicles are covalently attached to a supporting lipid bilayer using a DNA-templated click reaction; then DNA-mediated interactions between tethered vesicles are triggered by spiking the salt concentration. These interactions, such as docking and fusion, can then be observed for individual vesicles as they collide on the surface. The architecture of this new system also permits control over the number of lipid anchors that tether the vesicle to the supporting bilayer. The diffusion coefficient of tethered vesicles anchored by two lipids is approximately 1.6-fold slower than that of vesicles anchored only with a single lipid, consistent with a simple physical model.
Tumor-Associated Overexpression of the Soluble T1-S Receptor in Lymph Node–Negative Breast Cancer (2000)

The oncogene-inducible secreted T1-S glycoprotein is overexpressed in invasive breast carcinomas in mice. As yet, nothing is known about the expression of T1-S in spontaneously occurring human cancers. A report follows on the overexpression of T1-S mRNA in 67% of primary invasive lymph node-negative breast carcinomas (31 of 46 patients) as determined by quantitative reverse transcriptase polymerase chain reaction. Overexpression of T1-S mRNA was independent of the tumor size, the histologic tumor type, and the estrogen-and progesterone-receptor status but was associated with high to moderate differentiation of the tumors (G , G2). T1-S mRNA levels were low to nondetectable in resting normal mammary tissue and benign fibrocystic disease of the breast. Immunohistochemistry confirmed a low to moderate T1 immunoreactivity in epithelial cells of resting mammary tissue and benign fibrocystic disease and highly variable levels of T1 immunoreactivity in breast carcinoma cells. Kaplan-Meier analysis of disease-free survival during a median observation period of 61 months revealed a trend toward a reduced relapse rate and an extended relapse-free survival period for T1-S mRNA--overexpressing breast carcinomas. It is concluded that overexpression of T1-S receptor in lymph node-negative breast cancer may be a potential indicator for tumors with a low metastatic potential.
It's all a matter of good record keeping. (2003)

Here [the author] outlines her role, discusses how nurses occasionally cross her path and stresses the importance of good record keeping. (non-author abstract)
THE IDENTITY AND DISTRIBUTION OF SPECIES OF PSEUDALETIA (LEPIDOPTERA: NOCTUIDAE) IN AUSTRALIA (1965)

Abstract The distribution in Australia of the two armyworms Pseudaletia convecta (Walk.), of which P. australis Franclemont is shown to be a synonym, and P. separata (Walk.) has been determined. The genitalia of both sexes are figured and the characters used for distinguishing the two species are discussed.
Considerations for high data rate recording with thin-film heads (1990)

The significance of head inductance and eddy currents in limiting field rise times is discussed. Poor rise times can cause severe distortion and loss of performance at high data rates. A simple reluctance model is developed to explore the relationship between the geometry of a head and its inductance. The model is extended to include the effects of eddy currents, and to allow the frequency-dependent efficiency (hence the field rise time) to be calculated. Based on this rise time, a geometric model is used to calculate the positions of the recorded transitions and the resulting transition-shift distortion. Experimental results at transition separations down to 6 ns reveal a strong write current dependency which is not seen in the model. This dependence is, however, clearly seen in a simple domain wall model which implicitly includes magnetic saturation. Transition shift distortion can be mitigated by the use of precompensation. It is found that it is possible to successfully recover data at 180 Mbit/s using a conventional thin-film head.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Complete Rations for Dairy Cattle. V. Interaction of Sugarcane Bagasse Quantity and Form with Soybean Meal, Urea, and Starea (1975)

Sugarcane bagasse quantities (30 and 40%), form of bagasse pellet (bagasse pelleted right after processing or after ensiling), and soybean meal, urea, and Starea as sources of protein in complete rations were studied in a factorialized, incomplete block design with 36 lactating cows fed different rations in each of three 4-wk periods. Rations had crude protein of 12.1 to 13.9% (6.71% gross metabolizable protein) and crude fiber of 13.2 or 16%. Feed intake was lower for regular than for fermented bagasse pellets and for urea than for soybean meal and Starea rations. Milk fat percents we~'e higher for 40% than for 30% bagasse rations which resulted in greater solids-corrected milk yields. Soybean meal and Starea rations effected lower milk fat percents than urea rations. Milk protein yield was similar for soybean meal and Starea and higher than urea. Weight gains were greater with rations containing fermented pellets and less for urea. Rumen ammonia was higher for all rations at 1 h after feeding than 2 h. Rumen ammonia was similar for urea and Starea but higher than soybean meal at 1 h and 2 h. Rumen pH, molar proportions of acetate, and acetate:propionate ratios were higher and propionate
Adaptive Dynamic Programming: An Introduction (2009)

In this article, we introduce some recent research trends within the field of adaptive/approximate dynamic programming (ADP), including the variations on the structure of ADP schemes, the development of ADP algorithms and applications of ADP schemes. For ADP algorithms, the point of focus is that iterative algorithms of ADP can be sorted into two classes: one class is the iterative algorithm with initial stable policy; the other is the one without the requirement of initial stable policy. It is generally believed that the latter one has less computation at the cost of missing the guarantee of system stability during iteration process. In addition, many recent papers have provided convergence analysis associated with the algorithms developed. Furthermore, we point out some topics for future studies.
Samarium(II)-Iodide-Mediated Cyclizations in Natural Product Synthesis (2004)

SmI2 is a versatile reagent now widely used in organic chemistry. Despite the wealth of literature on the subject, the mechanisms of some SmI2-mediated reactions are still uncertain and the role of additives and cosolvents is poorly understood. This review covers the use of SmI2-mediated cyclization reactions in natural product synthesis. The use of the full armory of ring-forming reactions conducted by the reagent is outlined. Focus is on the most challenging targets, such as Taxol, gambierol, and diazonamide A.
Down-regulation of acetolactate synthase compromises Ol-1- mediated resistance to powdery mildew in tomato (2014)

ALS is neither involved in basal defense, nor in resistance conferred by NB-LRR type resistance genes. Instead, it is specifically involved in Ol-1-mediated resistance to tomato powdery mildew, suggesting that ALS-induced change in amino acid homeostasis is important for resistance conferred by Ol-1.
Cellular Uptake of Oligodeoxynucleotide Phosphorothioates and Their Analogs (1994)

The uptake and intracellular distribution of oligonucleotide phosphorothioates (S-oligonucleotides) and their analogs by various cells lines were studied using internally 35S-labeled oligonucleotides. Intracellular accumulation starts in the first 2 hr and reaches a maximum at about 16 hr. A decrease of intracellular concentration of the S-oligonucleotide was observed after 16 hr, probably due to a significant efflux transport. Cellular uptake was dependent on the extracellular concentration. The intracellular concentration was significantly higher than that in the medium. The uptake and the intracellular distribution were different in the various cell lines studied. Comparative studies of the uptake of the S-oligonucleotide and various 3' end-modified S-oligonucleotides show that end modified S-oligonucleotides with a hydrophobic group significantly increases the uptake. The introduction of methylphosphonothioate linkages at the 3' end of the S-oligonucleotide also resulted in an increase in uptake.
Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease (2008)

Damage to the gastrointestinal tract during graft-versus-host disease (GVHD) from the conditioning regimen in conjunction with alloreactive donor T cells plays a pivotal role in the pathogenesis of this disease. In this study, we have identified secretion of interleukin-23 (IL-23) by donor antigen-presenting cells (APCs) as a critical event in the induction of GVHD of the colon linking conditioning regimen-induced mucosal injury and lipopolysaccharide (LPS) translocation to subsequent proinflammatory cytokine production and GVHD-associated pathologic damage. In the absence of donor APC-derived IL-23 secretion, there is a selective and profound reduction in pathologic damage as well as a marked reduction in LPS and proinflammatory cytokine production in the colon microenvironment. The downstream proinflammatory effects of IL-23 are dependent upon donor-derived secretion of interferon-gamma (IFN-gamma), but are independent of donor IL-17 production. These findings define a novel organ-specific role for IL-23 in the pathophysiology of GVHD and demonstrate that IL-23 can direct tissue-specific pathology within the context of a systemic inflammatory disorder. Furthermore, these studies also identify IL-23 as a potential therapeutic target for the prevention of this life-threatening disorder.
Healthcom Indonesia. The use of radio spots to improve performance and motivation of kader. (1992)

Ethnographers interviewed village health volunteers (kader) mothers and village headman and observed child survival activities at village health and family planning posts (Posyandu) in the regencies of Jepara and Kendal in Central Java Indonesia to evaluate the potential for the broadcast of 2 radio spots over 3 months (a low cost means to motivate kader) to improve the performance of kader and reduce their dropout rates. In these villages the kaders job was to promote use of oral rehydration therapy and consumption of vitamin A supplements. Most mothers saw Posyandu as extensions of the health center so they did not feel obligated to take part in Posyandu activities. Even though the kader were supposed to represent the community they did their duties as though they were health center assistants. They tended to have a provider-user relationship with mothers rather than a mutually reciprocal relationships. Since mothers did not have a sense of ownership of Posyandu and did not feel close to kader they did not understand that Posyandu could positively influence their childrens health and survival. This misunderstanding discouraged kader. Kader mothers and village headmen listened to the radio spots. After the radio spot campaign most kader were happy with the spots messages went to Posyandu sessions more often and spoke with mothers about health more frequently more mothers valued the kader appreciated the Posyandu and frequented sessions. These findings suggested that similar radio spots should be broadcasted in more areas but more formative planning must be done beforehand to best understand the targeted community.
Discourses of “Forced Sterilization” in Puerto Rico: The Problem with the Speaking Subaltern (1998)

Research Article| July 01 1998 Discourses of "Forced Sterilization" in Puerto Rico: The Problem with the Speaking Subaltern Laura Briggs Laura Briggs laura briggs is Assistant Professor of Women's Studies at the University of Arizona. She is currently working on a book entitled Reproducing Empire: Discourses of Gender, Health, and Reproduction in the U.S. Imperial Project in Puerto Rico. Search for other works by this author on: This Site Google differences (1998) 10 (2): 30–66. https://doi.org/10.1215/10407391-10-2-30 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation Laura Briggs; Discourses of "Forced Sterilization" in Puerto Rico: The Problem with the Speaking Subaltern. differences 1 July 1998; 10 (2): 30–66. doi: https://doi.org/10.1215/10407391-10-2-30 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll Journalsdifferences Search Advanced Search The text of this article is only available as a PDF. Copyright © 1999 by Brown University and differences: A Journal of Feminist Cultural Studies1999 Article PDF first page preview Close Modal You do not currently have access to this content.