gebhart/patrepeval huggingface dataset:
Poly(hexyl‐substituted lactides): Novel injectable hydrophobic drug delivery systems (2006)

Poly(hexyl-substituted lactides) (PHLA) as new hydrophobic polyesters with controlled molecular weights and narrow distributions were synthesized by ring-opening polymerization (ROP) using tin(II) 2-ethylhexanoate (Sn(Oct)(2)) and benzyl alcohol as catalyst and initiator. Glass transition temperatures (T(g)) and zero shear viscosities (eta(0)) at 25 degrees C could be modulated from T(g)= -42 degrees C to -10 degrees C and 40 to 4850 Pa s, respectively, by varying the polymer molecular weight and the number of hexyl groups along the polymer chain. Degradation studies were performed in terms of both mass and molecular weight loss in the course of time. The degradation mechanism is shown to be of the "bulk erosion" type, and comparable to standard poly(D,L-lactide) (PLA). Despite the increased steric hindrance in the poly(monohexyl-substituted lactide) (PmHLA) due to the hexyl side groups, its degradation rate at pH 7.4 and 37 degrees C was found to be slightly higher than observed for the analogue standard PLA. This could be attributed to the flexible rubbery state of the hexyl-substituted polymer (T(g) approximately -15 degrees C) at the physiological temperature, which is favoring the degradation in comparison to the rigid and glassy standard PLA (T(g) approximately 40 degrees C). In contrast, degradation studies performed at 60 degrees C, where both polymers are above their glass transition temperature, confirmed that the degradation rate is lower for the sterically more hindered PmHLA. The degradation products were analyzed by ESI-MS. Hydrolysis lead first to the corresponding oligo-ester fragments and finally to the nontoxic 2-hydroxyoctanoic acid and lactic acid. Tetracycline was tested as a model drug for release studies. This drug was found to be released faster and in higher amounts in its active form from the PHLA matrix than from standard PLA. The results presented in this work demonstrate the potential of these hydrophobic polylactide-based semisolid materials as an alternative to conventional PLA/PLGA for injectable drug delivery systems.
Inhibition of Matrix Metalloproteinase 9 Activation by a Specific Monoclonal Antibody (1993)

Two members of the matrix metalloproteinase (MMP)1 family of enzymes are expressed at elevated levels in highly aggressive human tumor cells and have been implicated in the catalytic functions of extracellular proteolysis. The zymogen forms of these enzymes are designated proMMP-2 and proMMP-9, also known as 72kDa and 92kDa type IV collagenases/gelatinases, respectively. The MMP family of enzymes can be activated in vitro by a number of compounds including the organomercurial 4-aminophenylmercuric acetate (APMA). The natural or in vivo activators of MMP-2 and MMP-9 are at present unknown. A partially purified preparation of MMP-9 was used to immunize mice for the isolation of monoclonal antibodies (mAbs). Three IgG1 mAbs were identified by immunoreactivity with purified MMP-9 and are designated 6-6B, 7-11C, and 8-3H. These mAbs react specifically with MMP-9 by ELISA and Western blot. Additionally, these mAbs react with N-glycanase treated 92kDa protein. These mAbs were tested for their ability to inhibit enzyme activation in a radio-labeled gelatin assay. The 6-6B mAb inhibited the activation of MMP-9, but had no effect on MMP-2. These mAbs are highly specific to human MMP-9 and the 6-6B mAb will be extremely useful for examining the autolytic and catalytic activity of MMP-9 in normal and abnormal biological processes.
Randomized Clinical Trial of Adenosine 5'-Triphosphate in Patients With Advanced Non-Small-Cell Lung Cancer (2000)

This randomized trial demonstrates that ATP has beneficial effects on weight, muscle strength, and QOL in patients with advanced NSCLC.
Effects on the Periodontium Following Corticotomy‐Facilitated Orthodontics. Case Reports (1990)

This report describes the corticotomy surgical technique used in conjunction with orthodontic therapy and its effect on the periodontal status of the involved teeth. The surgical procedure included intracrevicular incisions and elevation of buccal and lingual mucoperiosteal flaps. Buccal and lingual vertical grooves penetrating the cortical bone were then made between the roots. These grooves were extended from just below the interproximal alveolar bone margin to beyond the apex levels of the teeth. Buccal and lingual horizontal grooves joined the apical extensions of the vertical grooves. The orthodontic appliance was activated immediately upon wound closure. Plaque scores, probing depths, and probing attachment levels were recorded before the surgical procedure and after the completion of the orthodontic treatment in 5 patients. The results showed that the corticotomy procedure caused minimal changes in the periodontal attachment apparatus.
Growth hormone-deficient dwarfism in the rat: a new mutation (1988)

Mutations in animals have provided insight into many aspects of normal and pathological human physiology. This paper reports the discovery and initial characterization of a new mutant dwarf rat. The mutation, inherited as an autosomal recessive, arose spontaneously in a breeding colony of Lewis rats at the Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford, U.K., in 1985 and the strain has now been established both in Oxford and at Mill Hill. Body growth in the mutant is retarded such that at 3 months of age both males and females weigh approximately 40% less than their normal litter-mates, and continue to grow at a slower rate. The mutants show a selective reduction in pituitary GH synthesis and storage (pituitary GH concentrations were approximately 10% of normal in males and 6% in females). The concentration of their anterior pituitary trophic hormones (LH, TSH, prolactin and ACTH) were within the normal range in dwarf animals. Exogenous GH treatment for 5 days resulted in an increase in growth rate from 1.5 +/- 0.3 to 3.9 +/- 0.4 g/day in male mutants, and 0.8 +/- 0.2 to 3.1 +/- 0.1 g/day in females. Longitudinal bone growth rates were more than doubled by this treatment from 49 +/- 5 to 100 +/- 10 micron/day in females and from 52 +/- 11 to 131 +/- 16 micron/day in males. Dot blot and Northern blot analysis of pituitary mRNA extracts revealed that the GH message in mutants was between 20 and 25% of normal, and that the GH transcript was of normal size.(ABSTRACT TRUNCATED AT 250 WORDS)
Jump map-based interactive texture synthesis (2004)

We present techniques for accelerated texture synthesis from example images. The key idea of our approach is to divide the task into two phases: analysis, and synthesis. During the analysis phase, which is performed once per sample texture, we generate a &lt;i&gt;jump map&lt;/i&gt;. Using the jump map, the synthesis phase is capable of synthesizing texture similar to the analyzed example at interactive rates. We describe two such synthesis phase algorithms: one for creating images, and one for directly texturing manifold surfaces. We produce texture images at rates comparable to the fastest alternative algorithms, and produce textured surfaces an order of magnitude faster than current alternative approaches. We further develop a new, faster patch-based algorithm for image synthesis, which improves the quality of our results on ordered textures. We show how controls used for specifying texture synthesis on surfaces may be used on images as well, allowing interesting new image-based effects, and highlight modelling applications enabled by the speed of our approach.
Analysis of localized erythema using clinical indicators and spectroscopy. (2003)

Localized erythema is regularly used as an indicator of post-ischemic events, including reactive hyperemia and Stage I pressure ulcers. The National Pressure Ulcer Advisory Panel definition of a Stage I ulcer includes both visual and nonvisual indicators in part to improve identification in darkly pigmented skin. A prospective, repeated-measures design was used to collect information on pressure-induced erythema that includes reactive hyperemia and Stage I pressure ulcers with an emphasis on distinguishing indicators in light and dark skin The relationships among clinical indicators (skin assessments) and results from tissue reflectance spectroscopy, as well as the clinical utility of spectroscopy for discerning tissue blanching status, were examined in a convenience sample of 76 inpatients and outpatients (95 test/control site pairs). Chi-square analysis and generalized logistic models were used to identify relationships and distinguishing characteristics of erythema. Analysis of variance was used to analyze blanching using spectroscopy. Nonblanching sites were more likely to be persistent erythema (c2=5.3; P = 0.021) but exhibited no relationships to temperature, tissue resilience, or disability. Erythema in subjects with dark skin was more likely to be nonblanching and have poor resilience. Spectrographic analysis of blanching found significant differences across skin pigmentation (P = 0.0001) and blanching status (P = 0.019). These results reinforce the belief that dark skin must be assessed differently than light skin and indicate that clinicians should use persistence of erythema rather than blanching status to judge incipient pressure ulcers. These results validate the use of visual and nonvisual indicators included in the National Pressure Ulcer Advisory Panel Stage I pressure ulcer definition.
Use of gene fusions to study expression of cysB, the regulatory gene of the cysteine regulon (1981)

Strains of escherichia coli were constructed in which the lacZ gene is fused to cysB, the positive regulator gene of the cysteine regulon. The fusion strains were used to study the regulation of the cysB gene by assaying the fused lacZ gene product. The introduction of a cysB allele, either on a plasmid or on an episome to the fusion strains, resulted in the decrease of beta-galactosidase activity. This implies that the cysB gene expression is autoregulated by its own product. The direction of cysB gene transcription was determined to be clockwise.
A force sensing Automated Insertion Tool for cochlear electrode implantation (2010)

Cochlear electrode insertion is a challenging manual procedure. One technique requires the physician to coordinate the motions of an electrode array approximately 1mm in diameter and the smaller stylet within it, using miniature forceps. A new minimally invasive access technique precludes forceps insertion because the electrode must travel through a small-diameter drilled hole to reach the cochlear access point. To address this, we present an automated insertion tool. This second generation device not only enables deployment in the minimally invasive setting, but also makes insertion velocity profiles repeatable and can sense insertion forces. Force sensing is essential because insertion forces can indicate impending damage to cochlear membranes, but are below the thresholds that can be sensed by human hands. The Automated Insertion Tool we present is designed to be compact and lightweight for straightforward integration into the operating room environment. It is able to insert an electrode with a resolution of less than 1μm, achieve velocities of up to 5 mm/sec and resolve forces as small as 0.005 N.
Temperature-Induced Protein Conformational Changes in Barley Root Plasma Membrane-Enriched Microsomes (1987)

The membrane-bound proteins of barley (Hordeum vulgare L. cv Conquest) root plasma membrane-enriched microsomes displayed fluorescence typical of protein-associated trytophan residues. The protein fluorescence intensity was sensitive to variations in sample temperature. The temperature-induced decline in protein fluorescence intensity was nonlinear with slope discontinuities at about 12 and 32 degrees C. Detergents at levels above their critical micelle concentration enhanced protein fluorescence. Glutaraldehyde reduced protein fluorescence. Protein fluorescence polarization increased at temperatures above 30 degrees C. Both the rate of tryptophan photoionization and the fluorescence intensity of the photoionization products suggested alterations in membrane protein conformation between 12 and 32 degrees C. The quenching of the intrinsic protein fluorescence by acrylamide and potassium iodide indicated changes in accessibility of the extrinsic agents to the protein tryptophan residues beginning at about 14 degrees C. The results indicate thermally induced changes in the dynamics of the membrane proteins over the temperature range of 12 to 32 degrees C which could account for the complex temperature dependence of the barley root plasma membrane ATPase.
Survival Analysis, a Self-Learning Text (1998)

Chapter 1. The basic ideas are considered: like event, survival time, censoring, survival function, hazard function. Data layouts and some descriptive measures are discussed. The principles of confounding and interaction are discussed. In a multivariable example the similarities and differences between linear, logistic regression and survival regression and the concept of a hazard ratio are discussed. This chapter was overall clear. In this book the hazard is introduced as the instantaneous potential per unit time for the event to occur. The derivation of the relationship between the hazard function and the survival function is not given (the author finds it not important, since a computer can do the calculations), while the calculations are easy to perform. We also missed a warning that censoring should be independent of the occurrence of an event. Competing risks and left censoring are mentioned but not treated in detail. Chapter 2. This chapter is about Kaplan-Meier curves, the log-rank test and the Peto test. The proof of the Kaplan-Meier formula is difficult to follow, just because the author is so hard trying to make it easy to understand. The log-rank test and Peto test are clearly explained. Chapter 3. Here the Cox Proportional Hazards model is discussed. The chapter starts with the computer output of a rather complex example with a treatment effect, a confounder plus an interaction term. Hereafter the general model is discussed. The partial likelihood is discussed but the formula is not given. The interpretation of the coefficients is discussed using the data example. Somewhere in the midst of several examples, the general rule is given, which is confusing. Chapter 4. Four different ways of checking the assumptions of the Cox model are discussed: log-log plots, comparing observed with model survival curves, Schonfeld's goodness of fit test and time dependent covariate methods. Suggestions are given about how to proceed in practice. Overall this is a good chapter, although the part about log-log plots is too elaborate. Chapter 5 is about stratification in the Cox model. There is a discussion of when to use stratification (if the PH assumption does not hold), and the possibility of interaction between the stratification variables and the other predictors is considered, with statistical tests. In Chapter 6 time dependent covariates are discussed. A distinction is made between two different situations. The first situation is a variable that changes in time (like employment status, smoking status). The second situation is a variable that is constant in time, but its effect on the hazard changes in time, so that the proportional hazards assumption does not hold. By multiplying the variable by some function of time, the model can be improved.
B7x: A widely expressed B7 family member that inhibits T cell activation (2003)

B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. B7x inhibits cell-cycle progression, proliferation, and cytokine production of both CD4+ and CD8+ T cells. B7x binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in downregulation of tissue-specific autoimmunity and antitumor responses.
Sum Capacity of Gaussian Vector Broadcast Channels (2004)

This paper characterizes the sum capacity of a class of potentially nondegraded Gaussian vector broadcast channels where a single transmitter with multiple transmit terminals sends independent information to multiple receivers. Coordination is allowed among the transmit terminals, but not among the receive terminals. The sum capacity is shown to be a saddle-point of a Gaussian mutual information game, where a signal player chooses a transmit covariance matrix to maximize the mutual information and a fictitious noise player chooses a noise correlation to minimize the mutual information. The sum capacity is achieved using a precoding strategy for Gaussian channels with additive side information noncausally known at the transmitter. The optimal precoding structure is shown to correspond to a decision-feedback equalizer that decomposes the broadcast channel into a series of single-user channels with interference pre-subtracted at the transmitter.
Differentiation into Endoderm Lineage: Pancreatic differentiation from Embryonic Stem Cells (2011)

The endoderm gives rise to digestive and respiratory tracts, thyroid, liver, and pancreas. Representative disease of endoderm lineages is type 1 diabetes resulting from destruction of the insulin-producing β cells. Generation of functional β cells from human embryonic stem (ES) cells in vitro can be practical, renewable cell source for replacement cell therapy for type 1 diabetes. It has been achieved by progressive instructive differentiation through each of the developmental stages. In this article, important studies of differentiation into pancreatic β cells from ES cells are reviewed through pancreatic developmental stages as definitive endoderm, primitive gut tube/foregut, and pancreatic cells. The investigation of differentiating ES cells from definitive endoderm to pancreas using signaling, arrays, and proteomics is also introduced.
Abstracting Workflows: Unifying Bioinformatics Task Conceptualization and Specification Through Semantic Web Services (2004)

Bioinformatics tasks often involve large scale data analysis that requires the integration of results from numerous computational tools, punctuated with data format conversions and human interaction. For high-
System-level power evaluation metrics (2002)

High-level power estimation is a key issue for IC designers and system engineers. The goal is to widely explore the architectural design space and to compare alternative solutions, while maintaining an acceptable accuracy and a competitive design time. In this paper, an approach is proposed for evaluating the system-level power consumption of embedded systems implemented by using VLSI circuits. Accurate and efficient early power evaluation metrics have been defined to guide the system-level partitioning phase of a more general HW/SW co-design approach for control dominated embedded systems. The hardware and software contributions to the power consumption at the system-level have been considered as well as the contribution of the HW/SW communication.
Dysregulation of Cellular Calcium Homeostasis in Chemotherapy-Evoked Painful Peripheral Neuropathy (2006)

Paclitaxel and vincristine are chemotherapeutic drugs that often evoke a long-lasting painful peripheral neuropathy. Using drugs that reduce intracellular or extracellular calcium ions (Ca2+), we investigated the hypothesis that impaired Ca2+ regulation contributes to the chemotherapy-evoked neuropathic pain syndrome. For comparison, we also tested rats with painful peripheral neuropathy caused by nerve trauma and to the anti-human immunodeficiency virus nucleoside analog 2',3'-dideoxycytidine (ddC). Normal naïve (without neuropathy), paclitaxel-treated, and vincristine-treated rats received the following intrathecal injections: TMB-8 (46 nmol), Quin-2 (1.8 nmol), EGTA (0.1 micromol), EGTA-am (0.1 micromol), and their vehicle controls. Chronic constriction injury (CCI) rats were examined after TMB-8 and Quin-2 injections, and ddC-treated rats were examined after receiving TMB-8. Mechano-allodynia and mechano-hyperalgesia were evaluated after each injection. Drug effects on heat hyperalgesia were also tested in CCI rats. All four Ca2+-reducing drugs significantly inhibited mechano-allodynia and mechano-hyperalgesia in the rats treated with paclitaxel, vincristine, or ddC, but no effects were seen in the CCI or naïve rats. We conclude that a similar abnormality of cellular Ca2+ homeostasis contributes to the pain caused by paclitaxel, vincristine, and ddC, but not posttraumatic painful peripheral neuropathy.
Synthesis and properties of novel psoralen derivatives (1988)

We have synthesized a set of new trimethylpsoralen derivatives that are characterized by a chain extending from the 4'-position of the furan ring and linked to this ring by an aminomethylene group. The nature of the side chain can be varied widely. In these derivatives, the chains contain either amino or ethylene oxide units for enhanced water solubility and allow the introduction of a thiol or amine group to nucleic acids. These compounds represent the first set of thiolated psoralen derivatives, and their usefulness is demonstrated in several nucleic acid cross-linking experiments. The reagents can be used to create both intraduplex reversible cross-links between the two single-strand partners in a DNA double helix and interduplex reversible cross-links between two DNA double helices.
Properties of Discrete Framelet Transforms (2013)

As one of the major directions in applied and computational harmonic analysis, the classical theory of wavelets and framelets has been extensively investigated in the function setting, in particular, in the function space L2(ℝd). A discrete wavelet transform is often regarded as a byproduct in wavelet analysis by decomposing and reconstructing functions in L2(ℝd) via nested subspaces of L2(ℝd) in a multiresolution analysis. However, since the input/output data and all filters in a discrete wavelet transform are of discrete nature, to understand better the performance of wavelets and framelets in applications, it is more natural and fundamental to directly study a discrete framelet/wavelet transform and its key properties. The main topic of this paper is to study various properties of a discrete framelet transform purely in the discrete/digital setting without involving the function space L2(ℝd). We shall develop a comprehensive theory of discrete framelets and wavelets using an algorithmic approach by directly studying a discrete framelet transform. The connections between our algorithmic approach and the classical theory of wavelets and framelets in the function setting will be addressed. Using tensor product of univariate complex-valued tight framelets, we shall also present an example of directional tight framelets in this paper.
Glucagon inhibits ghrelin secretion in humans (2005)

We show that i.m. glucagon decreases ghrelin significantly. Therefore, the already known stimulatory effects of i.m. glucagon on cortisol and GH are not mediated by a change in ghrelin concentrations. The mechanisms underlying the ghrelin suppression after i.m. glucagon are unlikely to include glucose or insulin variations and need to be further elucidated.