gebhart/patrepeval huggingface dataset:
A tingling sanshool derivative excites primary sensory neurons and elicits nocifensive behavior in rats (2011)

Szechuan peppers contain hydroxy-α-sanshool that imparts desirable tingling, cooling, and numbing sensations. Hydroxy-α-sanshool activates a subset of sensory dorsal root ganglion (DRG) neurons by inhibiting two-pore potassium channels. We presently investigated if a tingle-evoking sanshool analog, isobutylalkenyl amide (IBA), excites rat DRG neurons and, if so, if these neurons are also activated by agonists of TRPM8, TRPA1, and/or TRPV1. Thirty-four percent of DRG neurons tested responded to IBA, with 29% of them also responding to menthol, 29% to cinnamic aldehyde, 66% to capsaicin, and subsets responding to two or more transient receptor potential (TRP) agonists. IBA-responsive cells had similar size distributions regardless of whether they responded to capsaicin or not; cells only responsive to IBA were larger. Responses to repeated application of IBA at a 5-min interstimulus interval exhibited self-desensitization (tachyphylaxis). Capsaicin did not cross-desensitize responses to IBA to any greater extent than the tachyphylaxis observed with repeated IBA applications. These findings are consistent with psychophysical observations that IBA elicits tingle sensation accompanied by pungency and cooling, with self-desensitization but little cross-desensitization by capsaicin. Intraplantar injection of IBA elicited nocifensive responses (paw licking, shaking-flinching, and guarding) in a dose-related manner similar to the effects of intraplantar capsaicin and serotonin. IBA had no effect on thermal sensitivity but enhanced mechanical sensitivity at the highest dose tested. These observations suggest that IBA elicits an unfamiliar aversive sensation that is expressed behaviorally by the limited response repertoire available to the animal.
Vehicular Trajectory Optimization for Cooperative Collision Avoidance at High Speeds (2013)

Traffic safety is a key aspect in new-generation intelligent transportation systems. Among other areas, an active field of research is cooperative collision avoidance, where vehicles cooperatively calculate trajectories under tight time constraints to avoid colliding under specific road-traffic domains (overtaking, intersections, etc.). In this paper, we particularly analyze the problem of collision avoidance in scenarios in which high-speed vehicles need to generate evasive maneuvers within very short time intervals to avoid or at least mitigate a hypothetical (multiple) collision. We pose this as a multiobjective optimization problem and simplify it by considering only lateral motion for the optimization process, thus having to solve a 1-D trajectory generation problem. The routes of vehicles are optimized according to a weighted aggregation functional that: 1) maximizes the lateral distances between vehicle-vehicle and vehicle-obstacle pairs at the time of overcoming the obstacles; 2) minimizes the lateral speeds at the end of the path; and 3) minimizes the instantaneous lateral acceleration (inertia) along the maneuver. In addition, we compute trajectories by following an optimization strategy that divides the problem into a set of independent subproblems, which are optimized in parallel by using a gradient-descent-based methodology. From this set of solutions, the most suitable option, according to our selected criteria, is chosen. Results show the utility of our approach and its flexibility to compute evasive trajectories adapted to different requirements. Additionally, a simulation of the mechanical response of the vehicles during the evasive maneuvers is conducted.
Calculated elastic constants for stress problems associated with semiconductor devices (1973)

Theoretical estimates or experimental determinations of stress fields associated with semiconductor devices are generally simplified with the aid of two elastic constants, Young's modulus E and Poisson's ratio ν. In this paper, a generalized expression for ν has been derived for arbitrary orientations of cubic semiconductor crystals, and the variation of E, ν, and E/(1-ν) for directions within the important {111}, {100}, and {110} planes is examined. The results show that isotropic elasticity theory is exact for all directions within {111} planes and that the composite elastic constant E/(1-ν) which frequently occurs in problems of practical interest is also invariant for all directions within {100} planes. Numerical values for the various elastic constants are tabulated for GaAs, GaP, Si, and Ge.
The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis (2000)

Cellular stress can trigger a process of self-destruction known as apoptosis. Cells can also respond to stress by adaptive changes that increase their ability to tolerate normally lethal conditions. Expression of the major heat-inducible protein hsp70 protects cells from heat-induced apoptosis. hsp70 has been reported to act in some situations upstream or downstream of caspase activation, and its protective effects have been said to be either dependent on or independent of its ability to inhibit JNK activation. Purified hsp70 has been shown to block procaspase processing in vitro but is unable to inhibit the activity of active caspase 3. Since some aspects of hsp70 function can occur in the absence of its chaperone activity, we examined whether hsp70 lacking its ATPase domain or the C-terminal EEVD sequence that is essential for peptide binding was required for the prevention of apoptosis. We generated stable cell lines with tetracycline-regulated expression of hsp70, hsc70, and chaperone-defective hsp70 mutants lacking the ATPase domain or the C-terminal EEVD sequence or containing AAAA in place of EEVD. Overexpression of hsp70 or hsc70 protected cells from heat shock-induced cell death by preventing the processing of procaspases 9 and 3. This required the chaperone function of hsp70 since hsp70 mutant proteins did not prevent procaspase processing or provide protection from apoptosis. JNK activation was inhibited by both hsp70 and hsc70 and by each of the hsp70 domain mutant proteins. The chaperoning activity of hsp70 is therefore not required for inhibition of JNK activation, and JNK inhibition was not sufficient for the prevention of apoptosis. Release of cytochrome c from mitochondria was inhibited in cells expressing full-length hsp70 but not in cells expressing the protein with ATPase deleted. Together with the recently identified ability of hsp70 to inhibit cytochrome c-mediated procaspase 9 processing in vitro, these data demonstrate that hsp70 can affect the apoptotic pathway at the levels of both cytochrome c release and initiator caspase activation and that the chaperone function of hsp70 is required for these effects.
Compiler-based prefetching for recursive data structures (1996)

Software-controlled data prefetching offers the potential for bridging the ever-increasing speed gap between the memory subsystem and today's high-performance processors. While prefetching has enjoyed considerable success in array-based numeric codes, its potential in pointer-based applications has remained largely unexplored. This paper investigates compiler-based prefetching for pointer-based applications---in particular, those containing recursive data structures. We identify the fundamental problem in prefetching pointer-based data structures and propose a guideline for devising successful prefetching schemes. Based on this guideline, we design three prefetching schemes, we automate the most widely applicable scheme (greedy prefetching) in an optimizing research compiler, and we evaluate the performance of all three schemes on a modern superscalar processor similar to the MIPS R10000. Our results demonstrate that compiler-inserted prefetching can significantly improve the execution speed of pointer-based codes---as much as 45% for the applications we study. In addition, the more sophisticated algorithms (which we currently perform by hand, but which might be implemented in future compilers) can improve performance by as much as twofold. Compared with the only other compiler-based pointer prefetching scheme in the literature, our algorithms offer substantially better performance by avoiding unnecessary overhead and hiding more latency.
RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity (2015)

Semi-synthetic triterpenoids are antioxidant inflammation modulator (AIM) compounds that inhibit tumor cell growth and metastasis. Compounds in the AIM class bind to Keap1 and attenuate Nrf2 degradation. In the nucleus, Nrf2 increases antioxidant gene expression and reduces pro-inflammatory gene expression. By increasing Nrf2 activity, AIMs reduce reactive oxygen species and inflammation in the tumor microenvironment, which reverses tumor-mediated immune evasion and inhibits tumor growth and metastasis. AIMs also directly inhibit tumor cell growth by modulating oncogenic signaling pathways, such as IKKβ/NF-κB. Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. At low concentrations (≤ 25 nM), RTA 408 activated Nrf2 and suppressed nitric oxide and pro-inflammatory cytokine levels in interferon-γ-stimulated RAW 264.7 macrophage cells. At higher concentrations, RTA 408 inhibited tumor cell growth (GI50 = 260 ± 74 nM) and increased caspase activity in tumor cell lines, but not in normal primary human cells. Consistent with the direct effect of AIMs on IKKβ, RTA 408 inhibited NF-κB signaling and decreased cyclin D1 levels at the same concentrations that inhibited cell growth and induced apoptosis. RTA 408 also increased CDKN1A (p21) levels and JNK phosphorylation. The in vitro activity profile of RTA 408 is similar to that of bardoxolone methyl, which was well-tolerated by patients at doses that demonstrated target engagement. Taken together, these data support clinical evaluation of RTA 408 for cancer treatment.
Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man. (1989)

beta 2-IFN/hepatocyte stimulating factor/IL-6 is a cytokine secreted by monocytes, fibroblasts, and endothelial cells in cell culture that possesses diverse biologic activity including the stimulation of acute phase plasma protein synthesis and immunomodulation. The circulating levels of this cytokine in man in response to bacterial LPS (endotoxin) were studied. A single i.v. bolus of endotoxin (20 U/kg) produced a monophasic rise in circulating immunoreactive IFN-beta 2/IL-6 and IFN-beta 2/IL-6 bioactivity (hepatocyte stimulation and B cell differentiation assays) peaking 2 to 4 h after the endotoxin challenge. Peak IFN-beta 2/IL-6 levels ranged from 4.1 to 27.5 ng/ml. Associated with this was a rise in circulating C-reactive protein levels detected 20 h after the endotoxin bolus. Thus, IFN-beta 2/IL-6 is likely one of the endogenous mediators which is triggered in man during bacterial infection and likely participates in the metabolic and immune responses of the infected host.
A new bandwidth scalable wideband speech/audio coder (2002)

In this paper, we present a new bandwidth-scalable coder for wide band speech and audio signals. The proposed coder splits 8 kHz signal bandwidth into two narrow bands, and different coding schemes are applied to each band. The lower-band speech is coded with ITU-T G.729 Annex E, and the higher-band signal is compressed using a new algorithm based on the gammatone filter band with an invertible auditory model. Due to the split-band architecture and completely independent coding schemes for each band, the output speech of the decoder can be selected to be a narrowband or wideband coding according to the channel conditions. Subjective tests showed that, for wideband speech and audio signals, the proposed coder at 18 kbit/s produces superior quality to ITU-T 24 kbit/s G.722.1 with the shorter algorithmic delay.
Live single‐cell video‐mass spectrometry for cellular and subcellular molecular detection and cell classification (2008)

Abstract The molecular content from the cytoplasm of a live, single mammalian cell and its organelle were trapped with a nano‐electrospray ionization (ESI) tip acting as a micropipette under a video microscope, and hundreds of small molecular peaks were detected by direct nano‐ESI mass spectrometry (MS). Granule‐ or cytoplasm‐specific peaks in a mast cell (RBL 2H3) model were extracted by paired t ‐test to demonstrate their specific localization. Some of the typical and specific molecules were successfully identified by MS/MS analysis. This method was also applied to the cell classification of seven types of cell lines at the single‐cellular level by principal component analysis (PCA), revealing seven clusters in the multivariate score plot. Copyright © 2008 John Wiley &amp; Sons, Ltd.
On the Mechanism of Negative Differential Resistance in Ferrocenylundecanethiol Self-Assembled Monolayers (2005)

Negative differential resistance (NDR) peaks in the current-voltage characteristics of ferrocenylundecanethiol self-assembled monolayers are not reversible. The peaks turn to smoothly increasing currents as oxygen is removed from the system, indicating that NDR arises from the reaction of an energetic charged species with ambient oxygen.
Targeting the IAP Family of Caspase Inhibitors as an Emerging Therapeutic Strategy (2005)

The IAPs (inhibitor of apoptosis proteins) are a family of caspase inhibitors that block the execution phase of apoptosis. Overexpression of IAPs confers chemoresistance and, in some groups of patients, is associated with a poor prognosis. Given their role in the development and progression of solid tumors and hematologic malignancies, efforts are underway to develop therapeutic IAP inhibitors, with a focus on X-linked IAP (XIAP) and survivin. Antisense oligonucleotides that target XIAP and survivin have been developed and are currently in phase I clinical trial. Small-molecules that bind and inhibit XIAP have also been identified and are in the process of clinical development. This review focuses on the preclinical data that support the development of IAP-targeted therapies.
Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanisms of action. (1993)

Spinal cord stimulation has an anti-anginal and anti-ischaemic effect in severe coronary artery disease. These effects seem to be secondary to a decrease in myocardial oxygen consumption. Furthermore, myocardial ischemia during treatment gives rise to anginal pain. Thus, spinal cord stimulation does not deprive the patient of a warning signal.
Solvent effect on structural change of poly(vinyl alcohol) physical gels (1998)

In this study, the relationship between the polymer–solvent interaction and the network structure of poly(vinyl alcohol) (PVA) gels prepared with organic solvents such as N-methylpyrrolidone (NMP) and ethylene glycol (EG) are investigated. The values of the intrinsic viscosity [η] and Huggins constant k′ of dilute PVA solutions indicate that the attractive interaction between PVA and NMP is higher than that between PVA and EG. The X-ray result shows that PVA–EG gels have a (101) diffraction peak of PVA crystal that appeared at about 2θ = 19°, while PVA–NMP gels only show a broad amorphous scattering peak. On the other hand, Fourier transform infrared results of PVA/EG gels also clearly show an intense peak at 1141 cm−1 due to the crystalline absorption. The results of H1 pulsed nuclear magnetic resonance show that the spin–spin relaxation time, and respectively, related to the polymer-rich and polymer-poor components decrease, and the fractional amount of the polymer-rich component, fs, increases, while that of the polymer-poor component, fl, decreases with an increase in the concentration of polymer. At a given concentration, the value of fs in the PVA–EG gel is larger than that in the PVA–NMP one. These facts indicate that the crystallinity in the PVA–EG gel is higher than that in the PVA–NMP gel, implying that the aggregation of PVA chains is much easier in the poor solvent, EG, than in the good solvent, NMP. The structural change with aging time in the PVA–EG gel is very remarkable because of the significant syneresis, indicating that the opaque PVA–EG gel with higher crystallinity has a comparatively heterogeneous and unstable network structure than the PVA–NMP gel does. © 1998 John Wiley & Sons, Inc. J Appl Polym Sci 69: 2477–2486, 1998
Call Center Solutions (1991)

A Call Center is a business location that distributes a large volume of inbound or outbound calls to a group of agents or voice response systems. The goal of the Call Center is to provide the best possible service to its customers at the lowest possible cost, i.e., to minimize customer waiting time and maximize agent productivity. The Call Center architecture must be flexible enough to deal efficiently with peaks in offered volume, to provide the necessary data to manage Call Center operations effectively, and to add new customer services without significant changes to the existing architecture. As the range of services becomes more complex, the architecture must also support new elements, such as voice response units (VRUs), host interfaces, Integrated Services Digital Network (ISDN) interfaces, and multi-site Call Center networking. We describe the basic elements of Call Center architecture, focusing primarily on premises-based solutions. We illustrate Call Center configurations using the integrated private branch exchange/ automatic call distribution (PBX/ACD) feature of AT&T's Definity® communications system. We highlight the current and future benefits of ISDN, which promises both to improve customer service and reduce costs.
Gustatory Responses of the Hamster Mesocricetus auratus to Various Compounds Considered Sweet by Humans (1998)

The taste of 30 compounds was studied in the golden hamster with three different methods: single-fiber recordings, two-bottle preference (TBP), and conditioned taste aversion (CTA) tests. On the whole, the results showed that the sense of taste in the hamster differs in many respects from that in humans because, of 26 tested compounds known as sweet to humans, 11 had no taste or tasted differently. The results also supported the notion that activity in S-fibers elicits liking and activity in Q- or H-fibers rejection. Specifically hierarchial cluster analysis of 36 single fibers from the chorda tympani proper nerve separated N-, H-, and S-clusters consisting of 11 sucrose-, 14 NaCl-, and 11 citric-best fibers. Ace-K, cyanosuosan, N-4-cyanophenyl-N'-cyanoguanidineacetate (CCGA), -tryptophan, N-3, 5-dichlorophenyl-N'-(S)-alpha-methylbenzylguanidineacetate (DMGA), saccharin, SC-45647, and suosan stimulated only the S-fibers, were significantly preferred in TBP tests, and generalized to sucrose in the CTA tests. Ethylene glycol stimulated the N-fibers in addition to the S-fibers. This explains its generalization to sucrose in CTA. Its toxicity may contribute to its rejection in TBP tests. Sodium cyclamate stimulated a few N- but no S-fibers, which may explain the nondiscriminatory TBP and CTA results. Glycine elicited its largest response in the S-fibers, although it also stimulated other fibers. The resulting mixed taste sensation may explain why it was not preferred in TBP, although it generalized to sucrose in the CTA. Alitame, aspartame, N-4-cyanophenylcarbamoyl--aspartyl-(R)-alpha-methylbenzylamine (CAM), N-4-cyanophenylcarbamoyl-(R, S)-3-amino-3-(3, 4-methylenedioxyphenyl) propionic acid (CAMPA), N-(S)-2-methylhexanoyl--glutamyl-5-amino-2-pyridinecarbonitrile (MAGAP), N-1-naphthoyl--glutamyl-5-amino-2-pyridinecarbonitrile (NAGAP), NHDHC, superaspartame, and thaumatin were among the compounds considered sweet by humans that gave no response, were not discriminated in the TBP test, and gave no generalization in the CTA tests.
Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers (2000)

The existence of receptor dimers has been proposed for several G protein-coupled receptors. However, the question of whether G protein-coupled receptor dimers are necessary for activating or modulating normal receptor function is unclear. We address this question with somatostatin receptors (SSTRs) of which there are five distinct subtypes. By using transfected mutant and wild type receptors, as well as endogenous receptors, we provide pharmacological, biochemical, and physical evidence, based on fluorescence resonance energy transfer analysis, that activation by ligand induces SSTR dimerization, both homo- and heterodimerization with other members of the SSTR family, and that dimerization alters the functional properties of the receptor such as ligand binding affinity and agonist-induced receptor internalization and up-regulation. Double label confocal fluorescence microscopy showed that when SSTR1 and SSTR5 subtypes were coexpressed in Chinese hamster ovary-K1 cells and treated with agonist they underwent internalization and were colocalized in cytoplasmic vesicles. SSTR5 formed heterodimers with SSTR1 but not with SSTR4 suggesting that heterodimerization is a specific process that is restricted to some but not all receptor subtype combinations. Direct protein interaction between different members of the SSTR subfamily defines a new level of molecular cross-talk between subtypes of the SSTR and possibly related receptor families.
PET in differentiation of recurrent brain tumor from radiation injury. (2000)

The annual incidence of primary intracranial tumors is 7 to 19 cases per 100,000 people. The general approach to the treatment of brain neoplasms is surgical resection of solitary lesions or limited disease, followed by radiation therapy with or without chemotherapy. Multiple metastatic lesions are usually treated with whole-brain radiation. Radiation injury occurs in 5% to 37% of cases and can be difficult to differentiate from residual or recurrent malignancy by MRI. PET has been used to differentiate radiation injury from malignancy on the basis of differences in glucose uptake. Recent studies have reported the sensitivity and specificity of PET to be 81% to 86% and 40% to 94%, respectively. This article reviews the classification of primary brain tumors, the histologic changes associated with radiation injury, and the diagnostic and prognostic information provided by PET.
A 1.1V, 667MHz random cycle, asymmetric 2T gain cell embedded DRAM with a 99.9 percentile retention time of 110&#x00B5;sec (2010)

A logic compatible embedded DRAM test macro fabricated in a 65nm LP CMOS process has a 512 cells-per-BL array architecture and achieves a random access frequency and latency of 667MHz and 1.65nsec, respectively at 1.1V, 85°C. The refresh period for a 99.9% bit yield was 110μsec. Key features include an asymmetric 2T gain cell, a pseudo-PMOS diode based current sensing scheme, a half swing write BL driver, and a stepped write WL technique.