gebhart/patrepeval huggingface dataset:
Solid state NMR investigation of cationic polymerized epoxy resins (1992)

Abstract Cationic UV‐polymerized resins, based on cycloaliphatic epoxides with aryl sulfonium salts as photoinitiators and polypropylene glycols of variable length as flexibilizers, have been investigated with respect to the network‐forming reactions and the morphology of the resulting polymers. The combination of UV‐curing and thermal postcure makes the chemical process complex and dependent on many variables, such as photoinitiator, exposure time, reaction temperature, and polyol components. Structure and curing of the epoxide were investigated by 13 C CPMAS NMR. Morphology and domain sizes were studied by spin diffusion experiments using the novel “dipolar filter” technique for selective magnetization of mobile components.
PPARs and the kidney in metabolic syndrome (2008)

The metabolic syndrome (MetS) is defined by a set of metabolic risk factors, including insulin resistance, central obesity, dyslipidemia, hyperglycemia, and hypertension for type 2 diabetes and cardiovascular disease. Although both retrospective and prospective clinical studies have revealed that MetS is associated with chronic renal disease, even with a nondiabetic cause, the cellular and molecular mechanisms in this association remain largely uncharacterized. Recently, increasing evidence suggests that peroxisome proliferator-activated receptors (PPARs), a subgroup of the nuclear hormone receptor superfamily of ligand-activated transcription factors, may play an important role in the pathogenesis of MetS. All three members of the PPAR nuclear receptor subfamily, PPARalpha, -beta/delta, and -gamma, are critical in regulating insulin sensitivity, adipogenesis, lipid metabolism, inflammation, and blood pressure. PPARs have also been implicated in many renal pathophysiological conditions, including diabetic nephropathy and glomerulosclerosis. Ligands for PPARs such as hypolipidemic PPARalpha activators, and antidiabetic thiazolidinedione PPARgamma agonists affect not only diverse aspects of MetS but also renal disease progression. Emerging data suggest that PPARs may be potential therapeutic targets for MetS and its related renal complications. This review focuses on current knowledge of the role of PPARs in MetS and discusses the potential therapeutic utility of PPAR modulators in the treatment of kidney diseases associated with MetS.
Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective (2004)

The critical influence of chemokine biology on the outcome of allergic asthma continues to be highlighted in recent reports describing novel mechanisms by which eosinophils are recruited into the lung and local TH2-cell dominance is maintained. Also of considerable interest is the increasing emphasis currently being realized for structural cell participation, nonreceptor regulatory mechanisms, and the influence of susceptibility genes.
Nonproductive Infection and Induction of Cellular Deoxyribonucleic Acid Synthesis by Bovine Adenovirus Type 3 in a Contact-Inhibited Mouse Cell Line (1972)

Bovine adenovirus type 3 (BAV-3), which has been reported to produce tumors in newborn hamsters, induced cellular deoxyribonucleic acid (DNA) synthesis in a contact-inhibited mouse kidney cell line (C3H2K). In this system, the virus did not multiply, whereas virus-specific tumor antigen (T antigen) was detected in nearly all cells. Replication of viral DNA could not be detected by DNA-DNA hybridization on membrane filters. The cellular DNA synthesis induced by BAV-3 did occur in the absence of added serum. Extent of induction of cellular DNA synthesis was closely correlated with the multiplicity of infection. Cells activated to synthesize DNA in the serum-free medium by the virus infection progressed to cell division without noticeable cell killing.
Global Epidemiology of Influenza: Past and Present (2000)

Pandemics are the most dramatic presentation of influenza. Three have occurred in the twentieth century: the 1918 H1N1 pandemic, the 1957 H2N2 pandemic, and the 1968 H3N2 pandemic. The tools of molecular epidemiology have been applied in an attempt to determine the origin of pandemic viruses and to understand what made them such successful pathogens. An excellent example of this avenue of research is the recent phylogenetic analysis of genes of the virus that caused the devastating 1918 pandemic. This analysis has been used to identify evolutionarily related influenza virus genes as a clue to the source of the pandemic of 1918. Molecular methods have been used to investigate the avian H5N1 and H9N2 influenza viruses that recently infected humans in Hong Kong. Antigenic, genetic, and epidemiologic analyses have also furthered our understanding of interpandemic influenza. Although many questions remain, advances of the past two decades have demonstrated that several widely held concepts concerning the global epidemiology of influenza were false.
The evolution of multiple memory systems. (1987)

The existence of multiple memory systems has been proposed in a number of areas, including cognitive psychology, neuropsychology, and the study of animal learning and memory. We examine whether the existence of such multiple systems seems likely on evolutionary grounds. Multiple systems adapted to serve seemingly similar functions, which differ in important ways, are a common evolutionary outcome. The evolution of multiple memory systems requires memory systems to be specialized to such a degree that the functional problems each system handles cannot be handled by another system. We define this condition as functional incompatibility and show that it occurs for a number of the distinctions that have been proposed between memory systems. The distinction between memory for song and memory for spatial locations in birds, and between incremental habit formation and memory for unique episodes in humans and other primates provide examples. Not all memory systems are highly specialized in function, however, and the conditions under which memory systems could evolve to serve a wide range of functions are also discussed. Memory is a function that permits animals and people to acquire, retain, and retrieve many different kinds of information. It allows them to take advantage of previous experience to help solve the multitude of problems with which their environment confronts them, such as how to recognize the familiar, predict events, return to particular places, and assess the consequences of behavior Recently the question has arisen as to whether the
Acute Promyelocytic Leukemia (1993)

Discoveries in cancer research are rarely so exceptional that they both cause immediate changes in the treatment of patients and dramatically advance our understanding of the mechanisms underlying the disease. However, observations of the striking efficacy of all-trans-retinoic acid (tretinoin) in the treatment of patients with acute promyelocytic leukemia, followed closely by the discovery of a specific molecular genetic abnormality in a retinoid receptor, have greatly expanded scientific insight about leukemogenesis and have radically altered treatment strategies in this illness. The observation of tumor cells undergoing maturation as a patient enters remission has also provided a remarkable demonstration of drug-induced . . .
Use of the Mannan Receptor to Selectively Target Vaccine Antigens for Processing and Antigen Presentation through the MHC Class I and Class II Pathways (2002)

Extensive studies have shown that synthetic and recombinant vaccines developed against hemoparasites have not been as effective as whole parasites or crude membrane fractions in eliciting protective immunity. A possible reason is that synthetic vaccines are not being presented in a form that induces the appropriate immune response. We have developed a bovine model system to evaluate the ability of adjuvant compounds to induce an immune response to peptide antigens dominated by a cytokine profile with a Type 1 (cell-mediated) or Type 2 (humoral) bias. In the initial testing of this system, we found that mRNA expression of certain cytokines (interleukin [IL]-1beta, IL-6, IL-12, IL-15, GM-CSF, iNOS, and tumor necrosis factor [TNF]-alpha) is enhanced when monocyte-derived macrophages are stimulated with peptide antigen conjugated with mannan under oxidizing conditions compared to peptide conjugated with reduced mannan. The data suggest this model will be useful in identifying adjuvant systems that selectively modulate the cytokine profile of antigen presenting cells at the time of antigen presentation and the consequent downstream maturation of naive T cells to effector cells with Type 1 or Type 2 cytokine bias.
Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis (2000)

Many apoptotic molecules relocate subcellularly in cells undergoing apoptosis. The pro-apoptotic protein BID underwent posttranslational (rather than classic cotranslational) N-myristoylation when cleavage by caspase 8 caused exposure of a glycine residue. N-myristoylation enabled the targeting of a complex of p7 and myristoylated p15 fragments of BID to artificial membranes bearing the lipid composition of mitochondria, as well as to intact mitochondria. This post-proteolytic N-myristoylation serves as an activating switch, enhancing BID-induced release of cytochrome c and cell death.
Direct analysis of liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) (2008)

Desorption electrospray ionization-mass spectrometry (DESI-MS) was evaluated for the direct analysis of liquid samples. Several interesting results were found. First, in contrast to the previous DESI analysis of dried solid samples that was limited to proteins with MW < or = 25 kDa (Anal. Chem. 2007, 79, 3514), bovine serum albumin (BSA, 66 kDa) was successfully ionized from solutions by DESI with observation of corresponding multiply charged ions. Second, direct DESI analysis of protein tryptic digest solutions without chromatographic separation, sample clean-up, and the sample drying step was demonstrated, providing reasonably good sequence coverage of 52% to 97%. Third, direct analysis of biofluids such as an undiluted urine sample without sample pretreatment is possible, emphasizing the high tolerance of DESI with salt. These results suggest that a charged droplet pick-up mechanism is responsible for desorption and ionization of liquid samples by DESI. Also, unlike in electrospray ionization (ESI), inhibition of electrochemical reduction in the negative ion mode was observed for liquid sample DESI. In addition, reactive DESI can be performed with ion/ion reactions of Zn(II) complexes for the selective binding of phosphoserine in the presence of serine. DESI experiment can also be carried out directly to liquid samples flowing out of a pumped syringe needle tip, allowing rapid analysis. Furthermore, on-line coupling of electrochemical cell with DESI-MS was demonstrated, in which perylene radical cations generated in the cell were successfully transferred to the gas-phase for MS detection by DESI. This study extended the scope of DESI-MS applications, which could have potentials in bioanalytical and forensic analysis.
The Retinoid X Receptor Agonist Bexarotene Relieves Positive Symptoms of Schizophrenia (2013)

ClinicalTrials.gov identifier: NCT00535574.
Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs (2004)

Loud acoustic stimulation is known to cause inner ear disturbance. We examined immunohistochemically the vestibule of 12 guinea pigs after acoustic stimulation. The animals were divided into two equal groups: a control group and an acoustic stimulation group. The temporal bones were fixed by means of a cardiac infusion of fixative and immunohistochemically stained for inducible nitric oxide synthase (iNOS). The temporal bones in the control group did not show any iNOS. In the acoustic stimulation group, immunoreactivity for iNOS was detected in the supporting cells and sensory cells of the sensory epithelium, in the dark cell areas and in the vestibular ganglion cells. These findings suggest that free radicals are involved in the pathogenesis of noise-induced inner ear damage. Furthermore, free radicals may cause vestibular damage, as is seen in noise-induced inner ear damage.
History Matching of Three-Phase Flow Production Data (2003)

Summary Adjoint equations for 3D, three-phase flow problems are developed and implemented to calculate the sensitivity of production data to permeability fields and well skin factors. Typically, the development of adjoint equations is rather tedious, but the formulation given here makes the development and numerical solution of adjoint equations straightforward. The procedure for calculating sensitivity coefficients is coupled with a fully implicit finite-difference simulator to develop an automatic history-matching procedure. Even if one does not wish to fully automate history matching, sensitivity coefficients are useful for understanding the physics that control 3D multiphase flow and the influence of local reservoir properties on production data. Procedures to estimate the value of particular types of data [pressure, producing gas/oil ratio (GOR), and water/oil ratio (WOR)] for reducing the uncertainty in estimates of reservoir properties are applied and discussed.
Primary afferent nociceptor mechanisms mediating NGF‐induced mechanical hyperalgesia (2005)

The underlying mechanism for nerve growth factor (NGF) evoked pain and long-lasting mechanical hyperalgesia remains poorly understood. Using intrathecal antisense against the NGF receptor, receptor tyrosine kinase (TrkA), we found NGF to act at the primary afferent nociceptor directly in the Sprague-Dawley rat. Inhibitors of the three major pathways for TrkA receptor signalling, extracellular signal-related kinase (ERK)/mitogen-activated protein kinase kinase (MEK) (ERK/MEK), phosphatidylinositol 3-kinase (PI3K), and phospholipase Cgamma (PLCgamma) all attenuate NGF-induced hyperalgesia. Although inhibitors of kinases downstream of PI3K and PLCgamma[glycogen synthetase kinase 3 (GSK3), calmodulin-dependent protein kinase II (CAMII-K) or protein kinase C (PKC)] do not reduce mechanical hyperalgesia, hyperalgesia induced by activation of PI3K was blocked by ERK/MEK inhibitors, suggesting cross-talk from the PI3K to the ERK/MEK signalling pathway. As integrins have been shown to modulate epinephrine and prostaglandin E(2)-induced hyperalgesia, we also evaluated a role for integrins in NGF-induced mechanical hyperalgesia using beta(1)-integrin-specific antisense or antibodies.
Coexpression of the Maize d-Zein and b-Zein Genes Results in Stable Accumulation of d-Zein in Endoplasmic Reticulum-Derived Protein Bodies Formed by b-Zein (1997)

Suman Bagga, Henry P. Adams, Fabian D. Rodriguez, John D. Kemp, Champa Sengupta-Gopalan, Coexpression of the Maize δ-Zein and β-Zein Genes Results in Stable Accumulation of δ-Zein in Endoplasmic Reticulum-Derived Protein Bodies Formed by β-Zein, The Plant Cell, Vol. 9, No. 9 (Sep., 1997), pp. 1683-1696
Rubbery Block Copolymer Electrolytes for Solid‐State Rechargeable Lithium Batteries (1999)

For nearly 20 years, poly(ethylene oxide)‐based materials have been researched for use as electrolytes in solid‐state rechargeable lithium batteries. Technical obstacles to commercialization derive from the inability to satisfy simultaneously the electrical and mechanical performance requirements: high ionic conductivity along with resistance to flow. Herein, the synthesis and characterization of a series of poly(lauryl methacrylate)‐b‐poly[oligo(oxyethylene) methacrylate]‐based block copolymer electrolytes (BCEs) are reported. With both blocks in the rubbery state (i.e., having glass transition temperatures well below room temperature) these materials exhibit improved conductivities over those of glassy‐rubbery block copolymer systems. Dynamic rheological testing verifies that these materials are dimensionally stable, whereas cyclic voltammetry shows them to be electrochemically stable over a wide potential window, i.e., up to 5 V at 55°C. A solid‐state rechargeable lithium battery was constructed by laminating lithium metal, BCE, and a composite cathode composed of particles of (monoclinic), carbon black, and graphite in a BCE binder. Cycle testing showed the battery to have a high reversible capacity and good capacity retention. Li/BCE/Al cells have been cycled at temperatures as low as −20°C. © 1999 The Electrochemical Society. All rights reserved.
In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region (1999)

Recent studies have shown that long-term repopulating hematopoietic stem cells (HSCs) first appear in the aorta-gonad-mesonephros (AGM) region. Our immunohistochemistry study showed that TEK+cells existed in the AGM region. Approximately 5% of AGM cells were TEK+, and most of these were CD34+ and c-Kit+. We then established a coculture system of AGM cells using a stromal cell line, OP9, which is deficient in macrophage colony-stimulating factor (M-CSF). With this system, we showed that AGM cells at 10.5 days postcoitum (dpc) differentiated and proliferated into both hematopoietic and endothelial cells. Proliferating hematopoietic cells contained a significant number of colony-forming cells in culture (CFU-C) and in spleen (CFU-S). Among primary AGM cells at 10.5 dpc, sorted TEK+ AGM cells generated hematopoietic cells and platelet endothelial cell adhesion molecule (PECAM)-1+ endothelial cells on the OP9 stromal layer, while TEK− cells did not. When a ligand for TEK, angiopoietin-1, was added to the single-cell culture of AGM, endothelial cell growth was detected in the wells where hematopoietic colonies grew. Although the incidence was still low (1/135), we showed that single TEK+ cells generated hematopoietic cells and endothelial cells simultaneously, using a single-cell deposition system. This in vitro coculture system shows that the TEK+ fraction of primary AGM cells is a candidate for hemangioblasts, which can differentiate into both hematopoietic cells and endothelial cells.
On the Synthesis of Taurine (1936)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Synthesis of TaurineFrank CorteseCite this: J. Am. Chem. Soc. 1936, 58, 2, 191–192Publication Date (Print):February 1, 1936Publication History Published online1 May 2002Published inissue 1 February 1936https://pubs.acs.org/doi/10.1021/ja01293a002https://doi.org/10.1021/ja01293a002research-articleACS PublicationsRequest reuse permissionsArticle Views369Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Small Molecule Vascular Disrupting Agents: Potential New Drugs for Cancer Treatment (2007)

Vascular disrupting agents (VDAs) are a new class of potential anticancer drugs that selectively destroy tumor vasculature and shutdown blood supply to solid tumors, causing extensive tumor cell necrosis. VDAs target established tumor blood vessels, which are distinct from antiangiogenic agents that prevent the formation of new blood vessels. There are two types of VDAs, small molecules and ligand-directed agents. Most of the small molecule VDAs are tubulin inhibitors, including CA4P, ZD6126, AVE8062, OXi-4503, NPI-2358, MN-029 and EPC2407. The others are synthetic flavonoids including FAA and DMXAA that induce the production of local cytokines such as TNF-alpha. VDAs have shown good antitumor efficacy in animal models, especially in combination with established anticancer agents. Several VDAs, including CA4P and DMXAA, have demonstrated good safety profile as well as some promising efficacy in phase I clinical trials. Currently CA4P and DMXAA are in phase II clinical trials and AVE8062, OXi-4503, NPI-2358 and MN-029 are in phase I clinical trials. This review will focus on recent progress in the discovery and development of small molecule VDAs, including recently published patent applications and issued patents related with small molecule VDAs.
Studies on the biotransformation of ketamine 1—Identification of metabolites producedin vitro from rat liver microsomal preparations (1981)

The in vitro metabolic fate of the anesthetic agent ketamine [(+)2-o-chlorophenyl-2-methylaminocyclohexanone] has been evaluated using microsomal preparations from rat liver. With the aid of a rapid, nonselective metabolite extraction procedure and sample analysis by combined glass capillary gas chromatography low (and high) resolution mass spectrometry, eight metabolites of the drug were identified, six of which have not been reported previously. The novel metabolites were products of alicyclic ring hydroxylation of ketamine and of N-desmethylketamine (norketamine). Semi-quantitative analysis of metabolites produced during microsomal incubation was achieved using glass capillary gas chromatography. The results from this study indicate that 5,6-dehydronorketamine, previously considered to be a major biotransformation product of ketamine in mammalian systems, is almost certainly a methodological artefact.
Differentiation of vaccine and wild mumps viruses by polymerase chain reaction and nucleotide sequencing of the SH gene: Brief report (1995)

The nucleotide sequences of the SH gene and its F gene flanking region were determined over a range of 322 nucleotides for two live vaccines, two vaccine-associated isolates, six wild mumps viruses, and an attenuated mumps virus and compared to other sequences already published. Comparison revealed that the vaccine strains were clearly different from each other and the postvaccination isolates were different from the vaccines used. The viruses were assigned to three known cocirculating viral lineages. The attenuated mumps virus possesses nucleotide sequences identical to those of its progenitor strain.
Costs of hay fever in the United States in 1990. (1994)

Hay fever, or allergic rhinitis, affects a significant proportion of the US population. The current analysis focuses on the question of estimating both the direct and indirect costs of hay fever in the US for 1990. The basic data used for this analysis derive from continuing national probability surveys of 1) the US civilian noninstitutionalized population and 2) patient visits to offices of nonfederal practicing physicians who are not in hospital-based specialties. The analysis is based on current methods of estimating the costs of illness. The two major components of the estimates are the direct costs of physician visits, diagnostic tests, and medications; and the indirect costs associated with work absences or other reduced productivity for those employed both in and outside the home. For the most part where data were unavailable or potentially unreliable, cost estimates were not imputed. As a result, these estimates should be considered to be biased downward. In spite of these relatively conservative assumptions, the estimates of annual illness costs for 1990 totalled $1.8 billion.