gebhart/patrepeval huggingface dataset:
A Three-Dimensional Cinematographic Analysis of Upper Limb Movement during Fastball and Curveball Baseball Pitches (1993)

Joint angle kinematics of the throwing limb from the early-cocking phase to ball release were investigated for the fastball (FB) and curveball (CB) baseball pitches through use of a three-dimensional film analysis technique. Small sticks were fixed to the hand and forearm to permit rotations of the radioulnar and wrist joint to be calculated. The actions were very similar for two pitches within one subject. There were no differences in the motions of the shoulder and elbow joints or in the temporal sequences between FB and CB pitches. However, there was a significant difference ( p &lt;0.05) in the motion of supination/pronation of the forearm and dorsiflexion/palmar flexion of the wrist prior to the ball release; the forearm was supinated more in the CB (maximum supination: 39.9 ±6.0° at 0.072 ±0.045 s before ball release, or BRL) compared to the FB (19.4 ±8.5° at 0.076 ±0.046 s before BRL), whereas the wrist was dorsiflexed more in the FB (maximum dorsiflexion: 41.7 ±6.5° at 0.039 ±0.011 s before BRL) compared to the CB (31.2 ±4.7° at 0.036 ±0.013 s before BRL) during late-cocking and acceleration phases leading to the ball release.
One path to acoustic cloaking (2007)

A complete analysis of coordinate transformations in elastic media by Milton et al has shown that, in general, the equations of motion are not form invariant and thus do not admit transformation-type solutions of the type discovered by Pendry et al for electromagnetics. However, in a two-dimensional (2D) geometry, the acoustic equations in a fluid are identical in form to the single polarization Maxwell equations via a variable exchange that also preserves boundary conditions. We confirm the existence of transformation-type solutions for the 2D acoustic equations with anisotropic mass via time harmonic simulations of acoustic cloaking. We discuss the possibilities of experimentally demonstrating acoustic cloaking and analyse why this special equivalence of acoustics and electromagnetics occurs only in 2D.
Development of clinically relevant orthotopic xenograft mouse model of metastatic lung cancer and glioblastoma through surgical tumor tissues injection with trocar (2010)

Orthotopic model established with a trocar system is effective and injection of tumor tissues containing stem cells promise the forming of new tumor mass when grafted.
Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. (1988)

The gene encoding the beta-amyloid precursor protein has been assigned to human chromosome 21, as has a gene responsible for at least some cases of familial Alzheimer disease. Linkage studies strongly suggest that the beta-amyloid precursor protein and the product corresponding to familial Alzheimer disease are from two genes, or at least that several million base pairs of DNA separate the markers. The precise location of the beta-amyloid precursor protein gene on chromosome 21 has not yet been determined. Here we show, by using a somatic-cell/hybrid-cell mapping panel, in situ hybridization, and transverse-alternating-field electrophoresis, that the beta-amyloid precursor protein gene is located on chromosome 21 very near the 21q21/21q22 border and probably within the region of chromosome 21 that, when trisomic, results in Down syndrome.
Synthetic Experiments in the Ferrichrome Series* (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Experiments in the Ferrichrome Series*Samuel Rogers and J. B. NeilandsCite this: Biochemistry 1964, 3, 12, 1850–1855Publication Date (Print):December 1, 1964Publication History Published online1 May 2002Published inissue 1 December 1964https://pubs.acs.org/doi/10.1021/bi00900a010https://doi.org/10.1021/bi00900a010research-articleACS PublicationsRequest reuse permissionsArticle Views51Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the program size of perfect and universal hash functions (1982)

We address the question of program size of of perfect and universal hash functions. We prove matching upper and lower bounds (up to constant factors) on program size. Furthermore, we show that minimum or nearly minimum size programs can be found efficiently. In addition, these (near) minimum size programs have time complexity at most O(log* N) where N is the size of the universe in the case of perfect hashing, and time complexity 0(1) in the case of universal hashing. Thus for universal hashing programs of minimal size and minimal time complexity have been found.
Monte Carlo simultaneous localization of multiple unknown transient radio sources using a mobile robot with a directional antenna (2009)

We report our system and algorithm developments that enable a single mobile robot equipped with a directional antenna to simultaneously localize multiple unknown transient radio sources. Due to signal source anonymity, short transmission durations, and dynamic transmission patterns, the robot cannot treat the radio sources as continuous radio beacons.We model the radio source behaviors using a novel spatiotemporal probability occupancy grid (SPOG) that captures transient characteristics of radio transmissions and tracks the spatiotemporal posterior probability distribution of the radio transmissions. As a Monte Carlo method, we propose a ridge walking motion planning algorithm that enables the robot to efficiently traverse the high probability regions to accelerate the convergence of the posterior probability distribution. We have implemented the algorithms and the experiment results show that our method consistently outperforms methods such as a random walk or a fixed-route patrol mechanism.
Dictionary Design for Matching Pursuit and Application to Motion-Compensated Video Coding (2004)

We present a new algorithm for matching pursuit (MP) dictionary design. This technique uses existing vector-quantization design techniques and an inner product-based distortion measure to learn functions from a set of training patterns. While this scheme can be applied to many MP applications, we focus on motion-compensated video coding. Given a set of training sequences, data are extracted from the high-energy packets of the motion-compensated frames. Dictionaries with different regions of support are trained, pruned, and finally evaluated on MPEG test sequences. We find that for high bit-rate QCIF sequences we can achieve improvements of up to 0.66 dB with respect to conventional MP with separable Gabor functions.
Strengthening Health, Wellbeing and Equity: Embedding Policy-Level HIA in New Zealand (2006)

Policy-level health impact assessment (HIA) is a formal approach for assessing the impact of policies on health, wellbeing and equity. HIA is used by policymakers across government and by those who may be affected by policy. This paper outlines efforts to embed HIA in New Zealand, including development of an HIA guide for New Zealand, training to support its use and the promotion of HIA to key government agencies. It briefly presents three New Zealand HIA case studies. The paper reviews the uptake of HIA in New Zealand and identifies a range of factors (including awareness of the role and potential value of HIA, training in HIA, access to HIA expertise, political and managerial support for HIA, resourcing and statutory recognition) that influence whether agencies undertake HIA. The paper then discusses the future of HIA in New Zealand, identifying the need for legislation to encourage HIA, the value of embedding HIA in policy processes and the importance of a dedicated HIA support unit. The paper concludes that considerable progress has been made at this initial stage of embedding HIA and that the approach has an important contribution to make in strengthening health, wellbeing and equity in policymaking in New Zealand.
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity (2004)

Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 and -R2 serve as receptors for adiponectin and mediate increased fatty acid oxidation and glucose uptake by adiponectin. In the present study, we examined the expression levels and roles of AdipoR1/R2 in several physiological and pathophysiological states such as fasting/refeeding, obesity, and insulin resistance. Here we show that the expression of AdipoR1/R2 in insulin target organs, such as skeletal muscle and liver, is significantly increased in fasted mice and decreased in refed mice. Insulin deficiency induced by streptozotocin increased and insulin replenishment reduced the expression of AdipoR1/R2 in vivo. Thus, the expression of AdipoR1/R2 appears to be inversely correlated with plasma insulin levels in vivo. Interestingly, the incubation of hepatocytes or myocytes with insulin reduced the expression of AdipoR1/R2 via the phosphoinositide 3-kinase/Foxo1-dependent pathway in vitro. Moreover, the expressions of AdipoR1/R2 in ob/ob mice were significantly decreased in skeletal muscle and adipose tissue, which was correlated with decreased adiponectin binding to membrane fractions of skeletal muscle and decreased AMP kinase activation by adiponectin. This adiponectin resistance in turn may play a role in worsening insulin resistance in ob/ob mice. In conclusion, the expression of AdipoR1/R2 appears to be inversely regulated by insulin in physiological and pathophysiological states such as fasting/refeeding, insulin deficiency, and hyper-insulinemia models via the insulin/phosphoinositide 3-kinase/Foxo1 pathway and is correlated with adiponectin sensitivity.
Differing effects of PTH 1–34, PTH 1–84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: An 18-month open-labeled observational study using HR-pQCT (2012)

Whereas the beneficial effects of intermittent treatment with parathyroid hormone (PTH) (intact PTH 1-84 or fragment PTH 1-34, teriparatide) on vertebral strength is well documented, treatment may not be equally effective in the peripheral skeleton. We used high-resolution peripheral quantitative computed tomography (HR-pQCT) to detail effects on compartmental geometry, density, and microarchitecture as well as finite element (FE) estimated integral strength at the distal radius and tibia in postmenopausal osteoporotic women treated with PTH 1-34 (20 µg sc daily, n = 18) or PTH 1-84 (100 µg sc daily, n = 20) for 18 months in an open-label, nonrandomized study. A group of postmenopausal osteoporotic women receiving zoledronic acid (5 mg infusion once yearly, n = 33) was also included. Anabolic therapy increased cortical porosity in radius (PTH 1-34 32 ± 37%, PTH 1-84 39 ± 32%, both p < 0.001) and tibia (PTH 1-34 13 ± 27%, PTH 1-84 15 ± 22%, both p < 0.001) with corresponding declines in cortical density. With PTH 1-34, increases in cortical thickness in radius (2.0 ± 3.8%, p < 0.05) and tibia (3.8 ± 10.4%, p < 0.01) were found. Trabecular number increased in tibia with both PTH 1-34 (4.2 ± 7.1%, p < 0.05) and PTH 1-84 (5.3 ± 8.3%, p < 0.01). Zoledronic acid did not impact cortical porosity at either site but increased cortical thickness (3.0 ± 3.5%, p < 0.01), total (2.7 ± 2.5%, p < 0.001) and cortical density (1.5 ± 2.0%, p < 0.01) in tibia as well as trabecular volume fraction in radius (2.5 ± 5.1%, p < 0.05) and tibia (2.2 ± 2.2%, p < 0.01). FE estimated bone strength was preserved, but not increased, with PTH 1-34 and zoledronic acid at both sites, whereas it decreased with PTH 1-84 in radius (-2.8 ± 5.8%, p < 0.05) and tibia (-3.9 ± 4.8%, p < 0.001). Conclusively, divergent treatment-specific effects in cortical and trabecular bone were observed with anabolic and zoledronic acid therapy. The finding of decreased estimated strength with PTH 1-84 treatment was surprising and warrants confirmation.
Protection against canine distemper virus in dogs after immunization with isolated fusion protein (1986)

Canine distemper virus attachment (hemagglutinin [H] equivalent) and fusion (F) antigens were purified by affinity chromatography with monoclonal antibodies. The purified antigens were used to immunize groups of three dogs. Radioimmune precipitation assays with sera from these animals showed that the F antigen preparation was pure and induced only an F polypeptide-specific antibody response but that the H antigen preparation had a slight contamination by the F antigen. Immunized animals were challenged with virulent canine distemper virus. Two animals in each group developed pronounced humoral and cellular immune responses after challenge. Among these infected animals, only the dogs immunized with H antigen developed symptoms, albeit mild. In contrast, three nonimmunized control animals developed severe disease, with a fatal outcome in two cases. The complete resistance against challenge in two dogs was interpreted to reflect in one case anti-F immunity and in the other case most likely a high level of anti-H immunity. It is suggested that the F antigen may be of particular interest for the development of morbillivirus and possibly other paramyxovirus subunit or synthetic vaccines, because it can induce immunity capable of blocking virus infection and in situations of virus replication prevent the emergence of symptoms.
The gene expression signatures of melanoma progression (2005)

Because of the paucity of available tissue, little information has previously been available regarding the gene expression profiles of primary melanomas. To understand the molecular basis of melanoma progression, we compared the gene expression profiles of a series of nevi, primary melanomas, and melanoma metastases. We found that metastatic melanomas exhibit two dichotomous patterns of gene expression, which unexpectedly reflect gene expression differences already apparent in comparing laser-capture microdissected radial and vertical phases of a large primary melanoma. Unsupervised hierarchical clustering accurately separated nevi and primary melanomas. Multiclass significance analysis of microarrays comparing normal skin, nevi, primary melanomas, and the two types of metastatic melanoma identified 2,602 transcripts that significantly correlated with sample class. These results suggest that melanoma pathogenesis can be understood as a series of distinct molecular events. The gene expression signatures identified here provide the basis for developing new diagnostics and targeting therapies for patients with malignant melanoma.
A quantitative methodology for the de novo design of proteins (1994)

We have developed a general quantitative methodology for designing proteins de novo, which automatically produces sequences for any given plausible protein structure. The method incorporates statistical information, a theoretical description of protein structure, and motifs described in the literature. A model system embodying a portion of the quantitative methodology has been used to design many protein sequences for the phage 434 Cro and fibronectin type III domain folds, as well as several other structures. Residue sequences selected by this prototype share no significant identity with any natural protein. Nonetheless, 3-dimensional models of the designed sequences appear generally plausible. When examined using secondary structure prediction methods and profile analysis, the designed sequences generally score considerably better than the natural ones. The designed sequences are also in reasonable agreement with a sequence template. This quantitative methodology is likely to be capable of successfully designing new proteins and yielding fundamental insights about the determinants of protein structure.
A multi-stage pedestrian detection using monolithic classifiers (2011)

Despite the many efforts in finding effective feature sets or accurate classifiers for people detection, few works have addressed ways for reducing the computational burden introduced by the sliding window paradigm. This paper proposes a multi-stage procedure for refining the search for pedestrians using the HOG features and the monolithic SVM classifier. The multi-stage procedure is based on particle-based estimation of pdfs and exploits the margin provided by the classifier to draw more particles on the areas where the classifier's response is higher. This iterative algorithm achieves the same accuracy than sliding window using less particles (and thus being more efficient) and, conversely, is more accurate when configured to work at the same computational load. Experimental results on publicly available datasets demonstrate that this method, previously proposed for boosted classifiers only, can be successfully applied to monolithic classifiers.
Characterization of immunoglobulin binding by schistosomes (2006)

Although controversial, schistosomes are believed to cloak themselves in antibody through non-specific interactions with the immunoglobulin (Ig) molecule. The acquisition of host Ig by the schistosome may mask its foreign status and/or interfere with Fc-dependent functions. We report experiments aimed at characterizing the interaction between Ig-Fc and paramyosin, a schistosome Fc-receptor previously reported to bind human IgG. We show that certain Ig classes, in particular murine IgG2b and IgG3, are not only able to bind recombinant paramyosin, but also associate with other parasite proteins. The Fc region of IgG contains four hydrophobic patches, two of which are known to interact with distinct molecules: one in the Cgamma2-Cgamma3 interdomain region bound by protein G, mannose binding lectin (MBL), and the neonatal Fc-receptor (FcRn), and one at the top of the Cgamma2 domain bound by phagocytic FcgammaRs and C1q. We provisionally discounted the involvement of these regions, since IgG binding by paramyosin did not inhibit FcgammaR-mediated NADPH respiratory bursts, and protein G was unable to block IgG binding to paramyosin. Given their apparent low affinity, we postulate hydrogen bonding between reactive residues in a hydrophobic patch at the bottom of the Cgamma3 domain and negatively charged Glu or Asp amino acids in paramyosin.
Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism (1990)

In a blinded experiment, we report the first allelic association of the dopamine D2 receptor gene in alcoholism. From 70 brain samples of alcoholics and nonalcoholics, DNA was digested with restriction endonucleases and probed with a clone that contained the entire 3' coding exon, the polyadenylation signal, and approximately 16.4 kilobases of noncoding 3' sequence of the human dopamine D2 receptor gene (lambda hD2G1). In the present samples, the presence of A1 allele of the dopamine D2 receptor gene correctly classified 77% of alcoholics, and its absence classified 72% of nonalcoholics. The polymorphic pattern of this receptor gene suggests that a gene that confers susceptibility to at least one form of alcoholism is located on the q22-q23 region of chromosome 11.
Endoluminal vascular prostheses (1995)

This text provides a survey of current information on the development of endoluminal vascular prostheses. It covers practical issues in a how-to-do-it approach and will help the clinician to reduce patient trauma and operating time.
Highly tunable elastic dielectric metasurface lenses (2016)

Abstract Dielectric metasurfaces are two‐dimensional structures composed of nano‐scatterers that manipulate the phase and polarization of optical waves with subwavelength spatial resolution, thus enabling ultra‐thin components for free‐space optics. While high performance devices with various functionalities, including some that are difficult to achieve using conventional optical setups have been shown, most demonstrated components have fixed parameters. Here, we demonstrate highly tunable dielectric metasurface devices based on subwavelength thick silicon nano‐posts encapsulated in a thin transparent elastic polymer. As proof of concept, we demonstrate a metasurface microlens operating at 915 nm, with focal distance tuning from 600 μm to 1400 μm (over 952 diopters change in optical power) through radial strain, while maintaining a diffraction limited focus and a focusing efficiency above 50%. The demonstrated tunable metasurface concept is highly versatile for developing ultra‐slim, multi‐functional and tunable optical devices with widespread applications ranging from consumer electronics to medical devices and optical communications. image
Cytomegalovirus in the perfused human term placenta in vitro (1995)

Cytomegalovirus (CMV) is one of the most frequent causes of intrauterine-acquired infection in the human species. However, very little is known about the pathophysiology of the transplacental transmission of the virus from the mother to the fetus. In this study, the passage of CMV across the human term placenta, and the susceptibility of the human term trophoblast to infection with CMV was investigated. In vitro dual perfusion of human term placental lobules was performed. In five experiments the perfused tissue was exposed to high titres (10(4)-10(6) 50 per cent tissue culture infective doses) of CMV AD169 for up to 9.5 h. Monitoring included placental functional parameters, and virus titres in the perfused tissue, and in the fetal and maternal circuit. Immunocytochemistry with a monoclonal antibody against CMV immediate early antigen was used to search for placental infection. CMV AD169 did not cross the placenta even during many hours of perfusion, up to 9.5 h, and with exposure to high virus titres. No infected placental cells were detected by immunocytochemistry, although the virus cultures from perfused tissue samples were positive. The perfused human term placenta and the term trophoblast in vitro form an effective barrier to cell-free CMV AD169.