gebhart/patrepeval huggingface dataset:
Thermodynamic theory of the lead zirconate-titanate solid solution system (1989)

Abstract Compositions within the lead zirconate-titanate (PZT) solid solution system have been extensively used in polycrystalline ceramic form in a wide range of piezoelectric transducer application. However, the growth of good quality PZT single crystals for compositions across the entire phase diagram has not been accomplished. Due to the lack of single crystal data, an understanding of the properties of ceramic PZT has been limited. If the single domain (intrinsic) properties of PZT could be determined, then the extrinsic contributions (e.g., domain wall and defect motions) to the ceramic properties could be separated from the intrinsic contributions. The purpose of this research has been to develop a thermodynamic phenomenological theory to model the phase transitions and single domain properties of the PZT system. A two-sublattice theory, where each sublattice has a separate polarization, was used to account for the ferroelectric and antiferroelectric phases. An additional order parameter was also included to account for the tilting of the oxygen octahedra in the low temperature rhombohedral phase. The resulting energy function can be used to calcuate the phase diagram; spontaneous polarization, strain, tilt angle, and entropy change; and dielectric, piezoelectric, and elastic properties of the PZT system. Without single crystal data, the development of this theory was complicated and involved indirect methods of determining the coefficients of the energy function. To provide additional experimental data, a sol-gel method was used to prepare pure homogeneous powders of PZT compositions across the phase diagram. High temperature x-ray diffraction of these powders was used to determine the spontaneous strain which was related to the spontaneous polarization through the electrostrictive coefficients. These data were then used to determine some of the coefficients of the energy function, and to locate a second tricritical point between the cubic and tetragonal phases, where the transition changes from first to second order. The calculations from this theory are in good agreement with the available experimental data, and provide a method of predicting the intrinsic single domain properties of the PZT system. The extrinsic contributions of the properties of ceramic PZT can not be separated from these intrinsic contributions. This theory can also be used to study the effect of mechanical and electrical boundary conditions on the properties and phase stability, which will be useful in understanding ceramic materials. A future direction of this research is to extend the present theory into the lanthanum modified PZT system (PLZT) to further the understanding of relaxor type materials.
Capillary isotachophoresis from the student point of view – images and the reality (2006)

A review of some fundamental aspects of ITP from the student point of view, imaginations of some basic facts and laws, use of ITP, and the recent trends are presented. The results of theoretical computations of ITP separation processes are added for comparison of imaginations with the exact mathematical description.
Intramyocardial Injection of Allogenic Bone Marrow-Derived Mesenchymal Stem Cells Without Immunosuppression Preserves Cardiac Function in a Porcine Model of Myocardial Infarction (2005)

Direct intramyocardial injection of mesenchymal stem cells results in successful intramyocardial engraftment and differentiation into cardiomyocytes and endothelial cells and preserves left ventricular function after myocardial infarction in pigs.
A 10-Gb/s OEIC with Meshed Spatially-Modulated Photo Detector in 0.18-$\mu{\hbox {m}}$ CMOS Technology (2011)

This paper describes the design of a 10-Gb/s fully integrated CMOS optical receiver, which consists of a novel spatially-modulated photo detector (SMPD), a low-noise trans-impedance amplifier (TIA), and a post-limiting amplifier on a single chip. The bandwidth of proposed meshed SMPD can be boosted up to 6.9 GHz under a reverse-biased voltage of 14.2 V. The measured responsivity of the meshed SMPD is 29 mA/W as illuminated by 850-nm light source. To compensate the relatively low responsivity of on-chip CMOS photo detector (PD), a high-gain TIA with nested feedback and shunt peaking is proposed to achieve low-noise operation. The optical receiver is capable of delivering 25-kΩ conversion gain when driving 50-Ω output loads. For a PRBS test pattern of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> - 1, the 10-Gb/s optoelectronic integrated circuit (OEIC) has optical sensitivity of - 6 dBm at a bit-error rate (BER) of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-11</sup> . Implemented in a generic 0.18-μm CMOS technology, the chip area is 0.95 mm by 0.8 mm. The trans-impedance amplifier, post amplifier, and output buffer respectively drain 38 mW, 80 mW, and 27 mW from the 1.8-V supply.
Endothelin in the Control of Renal Sympathetic Nerve Activity (2011)

The kidney is densely innervated by sympathetic nerves. Increases in renal sympathetic nerve activity (RSNA) decrease urinary sodium excretion. The kidney also has abundant afferent sensory innervation, located primarily in the renal pelvic wall. Sympathetic nerve fibers and afferent nerve fibers often run separately but intertwined in the same nerve bundles in the renal pelvic wall, providing anatomic support for a functional interaction between RSNA and afferent renal nerve activity (ARNA). Activation of RSNA increases ARNA, which in turn decreases RSNA by activation of the renorenal reflexes. Thus, RSNA-induced increases in ARNA exert a powerful negative feedback control of RSNA via activation of the renorenal reflexes in the overall goal of maintaining low RSNA to facilitate urinary sodium excretion. A high-sodium diet enhances and a low-sodium diet reduces the RSNA-induced increases in ARNA. The physiologic importance of the dietary-induced changes in the RSNA-mediated increases in ARNA is underlined by salt-sensitive hypertension in rats lacking afferent renal innervation. Endothelin (ET), ET(A) receptors (R), and ET(B)-R are present in the renal pelvic wall. ET plays a modulatory role in the activation of the afferent renal nerves that is dependent on dietary sodium intake. In a high-sodium diet, increased activation of ET(B)-R facilitates the interaction between RSNA and ARNA resulting in suppression of RSNA, via activation of the renorenal reflexes, to limit sodium retention. In a low-sodium diet, increased activation of renal pelvic ET(A)-R suppresses the interaction between RSNA and ARNA which increases RSNA via impairment of the renorenal reflex mechanism, eventually leading to sodium retention. These findings suggest that the increased renal sympathetic nerve activity and salt-sensitive hypertension in ET-1/ET(B)-R-deficient subjects is, at least in part, related to suppressed interaction between RSNA and ARNA.
Zusammenfassung (1969)

Bei statischen Zugversuchen gefundene günstige Werte für Reißkraft und eine hierbei festgestellte gute Gleichförmigkeit gewährleisten nicht unbedingt auch eine geringe Fadenbruchzahl bei der Weiterverarbeitung. Ist hier mit in der Größe wechselnden Zugbeanspruchungen zu rechnen, dann besteht auch bei einer relativ kleinen, mit einfachen Meßgeräten bestimmten mittleren Fadenspannung die Gefahr, daß der Gespinst-(Zwirn-)verband aufgelockert wird und auseinanderschleift.
Efficient spatio-temporal hole filling strategy for Kinect depth maps (2012)

In this paper we present an efficient hole filling strategy that improves the quality of the depth maps obtained with the Microsoft Kinect device. The proposed approach is based on a joint-bilateral filtering framework that includes spatial and temporal information. The missing depth values are obtained applying iteratively a joint-bilateral filter to their neighbor pixels. The filter weights are selected considering three different factors: visual data, depth information and a temporal-consistency map. Video and depth data are combined to improve depth map quality in presence of edges and homogeneous regions. Finally, the temporal-consistency map is generated in order to track the reliability of the depth measurements near the hole regions. The obtained depth values are included iteratively in the filtering process of the successive frames and the accuracy of the hole regions depth values increases while new samples are acquired and filtered.
Measurement of de novo hepatic lipogenesis in humans using stable isotopes. (1991)

Direct measurement of de novo lipogenesis has not previously been possible in humans. We measured de novo hepatic lipogenesis in normal men by means of stable isotopes and by combining the acetylated-xenobiotic probe technique with mass isotopomer analysis of secreted very low density lipoprotein-fatty acids (VLDL-FA). Sulfamethoxazole (SMX) was administered with [13C]acetate during an overnight fast followed by refeeding with intravenous glucose (7-10 mg/kg of weight per min), oral Ensure (7-10 mg of carbohydrate/kg of weight per min), or a high-carbohydrate mixed-meal breakfast (3.5 g of carbohydrate/kg of weight). Respiratory quotients remained less than 1.0. High-performance liquid chromatography/mass spectrometry-determined enrichments in SMX-acetate attained stable plateau values, and hepatic acetyl-coenzyme A (CoA) dilution rate did not increase with refeeding (approximately 0.024 mmol/kg per min). The fraction of VLDL-palmitate derived from de novo lipogenesis was only 0.91 +/- 0.27% (fasted) and 1.64-1.97% (fed). For stearate, this was 0.37 +/- 0.08% and 0.47-0.64%. Precursor enrichments predicted from isotopomer ratios were close to measured SMX-acetate enrichments, indicating that SMX-acetate samples the true lipogenic acetyl-CoA pool. Stearate synthesis was less than palmitate and the two did not move in parallel. Estimated total VLDL-FA synthesis is less than 500 mg/day. Thus, de novo hepatic lipogenesis is a quantitatively minor pathway, consistent with gas exchange estimates; fatty acid futile cycling (oxidation/resynthesis) is not thermogenically significant; and synthesis rates of different nonessential fatty acids by human liver are not identical in nonoverfed normal men. The contribution and regulation of de novo lipogenesis in other settings can be studied using this technique.
Numerical simulation of quantum efficiency and surface recombination in HgCdTe IR photon-trapping structures (2013)

We have investigated the quantum effiency in HgCdTe photovoltaic pixel arrays employing a photon-trapping structure realized with a periodic array of pillars intended to provide broadband operation. We have found that the quantum efficiency depends heavily on the passivation of the pillar surface. Pillars passivated with anodicoxide have a large fixed positive charge on the pillar surface. We use our three-dimensional numerical simulation model to study the effect of surface charge and surface recombination velocity on the exterior of the pillars. We then evaluate the quantum efficiency of this structure subject to different surface conditions. We have found that by themselves, the surface charge and surface recombination are detrimental to the quantum efficiency but the quantum efficiency is recovered when both phenomena are present. We will discuss the effects of these phenomena and the trade offs that exist between the two.
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. (1997)

Here we describe the cloning and characterization of a PAS domain transcription factor termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia inducible factor (HIF-1alpha) and lesser similarity with other members of the basic helix-loop-helix/PAS domain family of transcription factors. Like HIF-1alpha, EPAS1 binds to and activates transcription from a DNA element originally isolated from the erythropoietin gene and containing the sequence 5'-GCCCTACGTGCTGTCTCA-3'. Activation by both HIF-1alpha and EPAS1 is stimulated by hypoxic conditions. EPAS1 forms a heterodimeric complex with the aryl hydrocarbon nuclear transporter prior to transcriptional activation of target genes. EPAS1 expression is limited to the endothelium of mouse embryos and, in agreement with its cell type-specific expression pattern, is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2. These observations raise the possibility that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia.
ASSOCIATION OF INSULIN RESISTANCE WITH BEAT-TO-BEAT CARDIOVASCULAR DYNAMICS IN NONOBESE, NON-DIABETIC INDIVIDUALS FROM LATINAMERICAN ORIGIN (2011)

Ochoa, J. E.; Correa, M. M.; Gallo, J. A.; McEwen, J. G.; Bilo, G.; Aristizabal, D.; Parati, G. Author Information
Insulin Resistance and Substrate Utilization in Human Endotoxemia (2000)

Infection results in a state of insulin resistance, but the pathogenesis is poorly understood. Intravenous administration of bacterial lipopolysaccharide (LPS) has been used to mimic the febrile and systemic inflammatory responses to infection, but it is unclear whether LPS induces insulin resistance in man. To investigate the effects of LPS on insulin sensitivity and substrate utilization, we administered, in paired cross-over studies, either 20 U/kg Escherichia coli endotoxin or saline control to healthy volunteers (n = 6) 120 min after the start of a 10-h euglycemic hyperinsulinemic clamp (insulin infusion rate, 80 mU/m2 x min). LPS induced a fever, tachycardia, and mild arterial hypotension. Glucose utilization increased abruptly 120 min after LPS administration (+64.1+/-12.0%; P < 0.003), but then declined progressively, and insulin resistance was evident by 420 min (+1.9+/-3.5%; P < 0.05). The reduction in glucose utilization, like that observed in sepsis, was related to impaired nonoxidative glucose disposal and not abnormal glucose oxidation. The cortisol and GH responses to LPS were of sufficient duration and magnitude to explain the insulin resistance. LPS administration results in metabolic responses very similar to those observed in sepsis and could provide a useful model for the study of insulin resistance in human critical illness.
Protein kinase activity associated with the avian sarcoma virus src gene product. (1978)

Incorporation of phosphorus from [gamma-32P]ATP into protein was catalyzed by specific immunoprecipitates from avian sarcoma virus (ASV)-transformed avian and mammalian cells. This incorporation was observed only when antiserum from tumor-bearing rabbits able to specifically precipitate the ASV sarcoma gene product, p60src, was used to immunoprecipitate antigens from transformed cell lysates. Immunoprecipitates of extracts from normal cells or cells infected with a transformation-defective ASV mutant showed no activity in this assay, nor did any immune complexes formed with normal rabbit serum and any of the cell extracts tested. The expression of the protein kinase activity (ATP:protein phosphotransferase, EC 2.7.1.37) was growth temperature-dependent in cells infected with an ASV mutant temperature-sensitive for the transformation. These results on an enzymatic activity associated with the ASV transforming protein are discussed in terms of protein phosphorylation as a mechanism for viral transformation.
Tandem Mass Spectrometry with Ultrahigh Mass Accuracy Clarifies Peptide Identification by Database Retrieval (2008)

A platform was developed to analyze MS/MS spectra from large peptides with low part-per-million mass accuracy, including a commercial-grade software suite. Termed Middle Down Proteomics, this platform identified 7454 peptides from 2-20 kDa (1472 unique) from 555 proteins after 23 LC-MS/MS injections of Lys-C digests of HeLa-S3 nuclear proteins. Along with greatly increased confidence for both peptide identification (expectation values from 10(-89) to 10(-4)) and characterization (up to 18% of peptides were modified in some LC-MS/MS runs), fragmentation data with <2 ppm accuracy enabled error tolerant and routine multiplexed database searching-all clearly demonstrated in this study.
Massive Mitochondrial Degeneration in Motor Neurons Triggers the Onset of Amyotrophic Lateral Sclerosis in Mice Expressing a Mutant SOD1 (1998)

Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Mutations in Cu,Zn superoxide dismutase (SOD1) are one cause of the disease. Mice transgenic for mutated SOD1 develop symptoms and pathology similar to those in human ALS. To understand the disease mechanism, we developed a simple behavioral assay for disease progression in mice. Using this assay, we defined four stages of the disease in mice expressing G93A mutant SOD1. By studying mice with defined disease stages, we tied several pathological features into a coherent sequence of events leading to motor neuron death. We show that onset of the disease involves a sharp decline of muscle strength and a transient explosive increase in vacuoles derived from degenerating mitochondria, but little motor neuron death. Most motor neurons do not die until the terminal stage, approximately 9 weeks after disease onset. These results indicate that mutant SOD1 toxicity is mediated by damage to mitochondria in motor neurons, and this damage triggers the functional decline of motor neurons and the clinical onset of ALS. The absence of massive motor neuron death at the early stages of the disease indicates that the majority of motor neurons could be rescued after clinical diagnosis.
Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process. (1987)

The superoxide-generating enzyme of human neutrophils, NADPH oxidase, is converted from an inactive to an active form upon stimulation of the neutrophil. This activation process was examined using a recently developed cell-free system in which dormant oxidase is activated by arachidonic acid in the presence of a soluble factor from the neutrophil (Curnutte, J. T. (1985) J. Clin. Invest. 75, 1740-1743). NADPH oxidase from unstimulated human neutrophils was detected only in the membrane fraction. The soluble activation factor was localized entirely to the cytosolic fraction and exhibited two peaks of activity when partially purified under nondenaturing conditions: a major peak with a molecular mass of approximately 250 kDa and a variable minor peak with a mass of approximately 40 kDa. Both forms activated NADPH oxidase in a similar manner and did not exhibit synergy when combined. The cytosolic factor is not protein kinase C (or another kinase) as both peaks of factor activity could be resolved from the protein kinase C peak and neither required calcium or ATP to activate the oxidase. Activation of NADPH oxidase did require the simultaneous presence of the membrane fraction, the cytosolic factor, arachidonic acid, and magnesium. Following activation, however, only the membrane fraction was then required for O2- production. Cytosolic factor levels were normal in five patients with either X-linked or autosomal recessive cytochrome b-negative chronic granulomatous disease. In contrast, the membrane fractions from each failed to generate O2-, indicating that the defects in these two genetic forms of chronic granulomatous disease reside either in the oxidase itself or in a membrane component required for activation.
A transient-kinetic study of the nitrogenase of Klebsiella pneumoniae by stopped-flow calorimetry. Comparison with the myosin ATPase (1989)

The pre-steady-state kinetics of MgATP hydrolysis by nitrogenase from Klebsiella pneumoniae were studied by stopped-flow calorimetry at 6 degrees C and at pH 7.0. An endothermic reaction (delta Hobs. = +36 kJ.mol of ATP-1; kobs. = 9.4 s-1) in which 0.5 proton.mol of ATP-1 was released, has been assigned to the on-enzyme cleavage of MgATP to yield bound MgADP + Pi. The assignment is based on the similarity of these parameters to those of the corresponding reaction that occurs with rabbit muscle myosin subfragment-1 (delta Hobs. = +32 kJ.mol of ATP-1; kobs. = 7.1 s-1; 0.2 proton released.mol of ATP-1) [Millar, Howarth & Gutfreund (1987) Biochem. J. 248, 683-690]. MgATP-dependent electron transfer from the nitrogenase Fe-protein to the MoFe-protein was monitored by stopped-flow spectrophotometry at 430 nm and occurred with kobs. value of 3.0 s-1 at 6 degrees C. Thus, under these conditions, hydrolysis of MgATP precedes electron transfer within the protein complex. Evidence is presented that suggests that MgATP cleavage and subsequent electron transfer are reversible at 6 degrees C with an overall equilibrium constant close to unity, but that, at 23 degrees C, the reactions are essentially irreversible, with an overall equilibrium constant greater than or equal to 10.
Acoustic Signature of the Normal Swallow: Characterization by Age, Gender, and Bolus Volume (2002)

Despite growing clinical use, cervical auscultation suffers from a lack of research-based data. One of the strongest criticisms of cervical auscultation is that there has been little research to demonstrate how dysphagic swallowing sounds are different from normal swallowing sounds. In order to answer this question, however, one first needs to document the acoustic characteristics of "normal," nondysphagic swallowing sounds. This article provides the first normative database of normal swallowing sounds for the adult population. The current investigation documents the acoustic characteristics of normal swallowing sounds for individuals from 18 to more than 60 years of age over a range of thin liquid volumes. Previous research has shown the normal swallow to be a dynamic event. The normal swallow is sensitive to aging of the oropharyngeal system, and also to the volume of bolus swallowed. The current investigation found that the acoustic signals generated during swallowing were sensitive to an individual's age and to the volume of the bolus swallowed. There were also some gender-specific differences in the acoustic profile of the swallowing sound. It is anticipated that the results will provide a catalyst for further research into cervical auscultation.
Multi-Commodity Network Flow for Tracking Multiple People (2013)

In this paper, we show that tracking multiple people whose paths may intersect can be formulated as a multi-commodity network flow problem. Our proposed framework is designed to exploit image appearance cues to prevent identity switches. Our method is effective even when such cues are only available at distant time intervals. This is unlike many current approaches that depend on appearance being exploitable from frame-to-frame. Furthermore, our algorithm lends itself to a real-time implementation. We validate our approach on three publicly available datasets that contain long and complex sequences, the APIDIS basketball dataset, the ISSIA soccer dataset, and the PETS'09 pedestrian dataset. We also demonstrate its performance on a newer basketball dataset that features complete world championship basketball matches. In all cases, our approach preserves identity better than state-of-the-art tracking algorithms.