gebhart/patrepeval huggingface dataset:
Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin A. (1984)

Three-day, concanavalin A-induced T lymphoblasts have been used as a model to study lymphokine release from sensitized T cells. The blasts responded to interleukin 2 (IL-2) but did not constitutively produce this or other lymphokines. After mitogen restimulation, blast cells synthesized IL-2 as well as gamma-interferon, B cell-stimulating factor(s), and cytolytic differentiation factor(s). This production resulted from the induction of biologically active lymphokine mRNA. Cyclosporin A (CSA), a potent immunosuppressive agent, strongly inhibited synthesis of IL-2, gamma-interferon, and B cell- and CTL-stimulating factor(s), from mitogen-restimulated T blasts. In contrast, CSA did not block the cytolytic activity of the T blasts, nor modify bulk protein synthesis induced by Con A. CSA also blocked lymphokine release from a phorbol myristate acetate-stimulated thymoma cell line, EL-4. The effect of CSA was to block the induction of active lymphokine mRNA, as assayed in an oocyte translation system. This selective inhibition of lymphokine mRNA suggests that CSA may be useful in the therapy of inflammatory, lymphokine-mediated disease states.
Simultaneous Electronic and Ionic Conduction in a Block Copolymer: Application in Lithium Battery Electrodes (2011)

Charging ahead: separate values for the simultaneous electronic and ionic conductivity of a conjugated polymer containing poly(3-hexylthiophene) and poly(ethylene oxide) (P3HT-PEO) were determined by using ac impedance and dc techniques. P3HT-PEO was used as binder, and transporter of electronic charge and Li(+) ions in a LiFePO(4) cathode, which was incorporated into solid-state lithium batteries.
Two‐ and three‐dimensional crystallization of polymeric microspheres by micromolding in capillaries (1996)

Micromolding in capillaries (MIMIC) is a novel, simple and convenient procedure for crystallizing microspheres from latex suspensions onto a support, and for delivering microspheres to and assembling them in geometrically confined regions on the surface of substrate (see figure). The principle of the method is outlined, examples are given, and possibilities for applications—e.g., in optical devices and microelectronics—are sketched. magnified image
The Human Transcription Enhancer Factor-1, TEF-1, Can Substitute for Drosophila scalloped during Wingblade Development (1997)

The human transcription enhancer factor-1 (TEF-1) belongs to a family of evolutionarily conserved proteins that have a DNA binding TEA domain. TEF-1 shares a 98% homology with Drosophila scalloped (sd) in the DNA binding domain and a 50% similarity in the activation domain. We have expressed human TEF-1 in Drosophila under the hsp-70 promoter and find that it can substitute for Sd function. The transformants rescue the wingblade defects as well as the lethality of loss-of-function alleles. Observation of reporter activity in the imaginal wing discs of the enhancer-trap alleles suggests that TEF-1 is capable of promoting sd gene regulation. The functional capability of the TEF-1 product was assessed by comparing the extent of rescue by heat shock (hs)-TEF-1 with that of hs-sd. The finding that TEF-1 can function in vivo during wingblade development offers a potent genetic system for the analysis of its function and in the identification of the molecular partners of TEF-1.
Why molecules move along a temperature gradient (2006)

Molecules drift along temperature gradients, an effect called thermophoresis, the Soret effect, or thermodiffusion. In liquids, its theoretical foundation is the subject of a long-standing debate. By using an all-optical microfluidic fluorescence method, we present experimental results for DNA and polystyrene beads over a large range of particle sizes, salt concentrations, and temperatures. The data support a unifying theory based on solvation entropy. Stated in simple terms, the Soret coefficient is given by the negative solvation entropy, divided by kT. The theory predicts the thermodiffusion of polystyrene beads and DNA without any free parameters. We assume a local thermodynamic equilibrium of the solvent molecules around the molecule. This assumption is fulfilled for moderate temperature gradients below a fluctuation criterion. For both DNA and polystyrene beads, thermophoretic motion changes sign at lower temperatures. This thermophilicity toward lower temperatures is attributed to an increasing positive entropy of hydration, whereas the generally dominating thermophobicity is explained by the negative entropy of ionic shielding. The understanding of thermodiffusion sets the stage for detailed probing of solvation properties of colloids and biomolecules. For example, we successfully determine the effective charge of DNA and beads over a size range that is not accessible with electrophoresis.
Enhanced photosensitivity in tin-codoped germanosilicate optical fibers (1995)

Enhanced photosensitivity is found in tin-codoped germanosilicate optical fibers. A photo-induced refractive index change (/spl sim/1.4×10/sup -3/) 3 times larger than that observed in pure germanosilicate fibers has been demonstrated. Unlike the technique of using boron-codoping to enhance the photosensitivity of germanosilicate fibers, tin-doping does not have a significant effect on fiber loss at the important telecommunication window of 1.55 μm. High temperature stability of the gratings in tin-codoped germanosilicate fibers is also much over boron-codoped fibers.
Isolation and characterization of an Escherichia coli mutant lacking the cytochrome o terminal oxidase (1985)

A respiration-deficient mutant of Escherichia coli has been isolated which is unable to grow aerobically on nonfermentable substrates such as succinate and lactate. Spectroscopic and immunological studies showed that this mutant lacks the cytochrome o terminal oxidase of the high aeration branch of the aerobic electron transport chain. This strain carries a mutation in a gene designated cyo which is cotransducible with the acrA locus. Mutations in cyo were obtained by mutagenizing a strain that was cyd and, thus, was lacking the cytochrome d terminal oxidase. Strain RG99, which carries both the cyd- and cyo- alleles, grows normally under anaerobic conditions in the presence of nitrate. Introduction of the cyd+ allele into the strain restores the respiration function of the strain, indicating that the cytochrome o branch of the respiratory chain is dispensable under normal laboratory growth conditions.
DeepFace: Closing the Gap to Human-Level Performance in Face Verification (2014)

In modern face recognition, the conventional pipeline consists of four stages: detect => align => represent => classify. We revisit both the alignment step and the representation step by employing explicit 3D face modeling in order to apply a piecewise affine transformation, and derive a face representation from a nine-layer deep neural network. This deep network involves more than 120 million parameters using several locally connected layers without weight sharing, rather than the standard convolutional layers. Thus we trained it on the largest facial dataset to-date, an identity labeled dataset of four million facial images belonging to more than 4, 000 identities. The learned representations coupling the accurate model-based alignment with the large facial database generalize remarkably well to faces in unconstrained environments, even with a simple classifier. Our method reaches an accuracy of 97.35% on the Labeled Faces in the Wild (LFW) dataset, reducing the error of the current state of the art by more than 27%, closely approaching human-level performance.
Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples (2018)

The high sensitivity and specificity of the circulating miRNAs may enable early diagnosis of PD. The study provides a group of novel miRNA candidates for detecting PD.
UNTERSUCHUNG DER NOX-REDUZIERUNG IM ABGAS VON DIESELMOTOREN DURCH SCR-KATALYSATOREN (1993)

Um den in der Konkretisierung der TA-Luft festgelegten Grenzwert zu erreichen, ist eine deutliche Verminderung der NOx-Emission von stationaeren Dieselmotoren erforderlich. Zur Absenkung der NOx-Emission sind SCR-Katalysatoren geeignet. Bei diesem Verfahren wird ein Reduktionsmittel (meist Ammoniak) vor den Katalysator in das Abgassystem eingespritzt. Durch diese Abgasnachbehandlung ist es moeglich, die Stickoxidemission auf die erforderlichen Grenzwerte abzusenken. Dieselmotoren werden jedoch haeufig instationaer betrieben. Zur Untersuchung des Betriebsverhaltens von SCR-Katalysatoren wird im Abgas eines DI-Saugdieselmotors mit 11,4 l Hubraum die NOx-Reduktion an sechs unterschiedlichen SCR-Katalysatoren im stationaeren sowie im instationaeren Motorbetrieb untersucht. Als Reduktionsmittel wird NH3 verwendet. Neben NOx werden die Emissionen nach Katalysator von NH3, HC, CO, und Sulfaten bestimmt. Bericht aus der Taetigkeit der Forschungsvereinigung Verbrennungskraftmaschinen e.V. Titel in Englisch: Investigation of the NOx reduction in diesel exhaust gas by SCR catalysts.
Protein Kinase C Modulates Inactivation of Kv3.3 Channels (2008)

Modulation of some Kv3 family potassium channels by protein kinase C (PKC) regulates their amplitude and kinetics and adjusts firing patterns of auditory neurons in response to stimulation. Nevertheless, little is known about the modulation of Kv3.3, a channel that is widely expressed throughout the nervous system and is the dominant Kv3 family member in auditory brainstem. We have cloned the cDNA for the Kv3.3 channel from mouse brain and have expressed it in a mammalian cell line and in Xenopus oocytes to characterize its biophysical properties and modulation by PKC. Kv3.3 currents activate at positive voltages and undergo inactivation with time constants of 150-250 ms. Activators of PKC increased current amplitude and removed inactivation of Kv3.3 currents, and a specific PKC pseudosubstrate inhibitor peptide prevented the effects of the activators. Elimination of the first 78 amino acids of the N terminus of Kv3.3 produced noninactivating currents suggesting that PKC modulates N-type inactivation, potentially by phosphorylation of sites in this region. To identify potential phosphorylation sites, we investigated the response of channels in which serines in this N-terminal domain were subjected to mutagenesis. Our results suggest that serines at positions 3 and 9 are potential PKC phosphorylation sites. Computer simulations of model neurons suggest that phosphorylation of Kv3.3 by PKC may allow neurons to maintain action potential height during stimulation at high frequencies, and may therefore contribute to stimulus-induced changes in the intrinsic excitability of neurons such as those of the auditory brainstem.
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine. (1991)

We investigated the major products of proglucagon (PG) processing in plasma in the fasting state, after intravenous arginine and after an oral glucose load in noninsulin-dependent diabetics (NIDDM) and in weight matched controls using specific radioimmunoassays and analytical gel filtration. In the fasting state the glucagonlike peptide-1 (GLP-1) immunoreactivity was significantly elevated in the NIDDM group compared with the control group. Both after intravenous arginine and after an oral glucose load a rise in the plasma concentrations of all immunoreactive moieties measured was seen. All integrated incremental responses after intravenous arginine were identical in the two groups. After oral glucose the insulin concentrations in plasma were lower and the concentrations of all proglucagon products were higher in the NIDDM group compared to the control group. The gel filtration analysis showed that arginine stimulated the secretion of pancreatic glucagon (PG 33-61), major proglucagon fragment (PG 72-158) and probably GLP-1 (PG 72-107 amide) in both groups, whereas oral glucose stimulated the secretion of glicentin (PG 1-69) and intestinal GLP-1 (PG 78-107 amide), an insulinotropic hormone. The elevated levels of immunoreactive GLP-1 in diabetics in the fasting state were mainly due to an increased concentration of major proglucagon fragment.
SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity (2002)

The sensitive telomeric repeat amplification protocol (TRAP) permits telomerase detection in mammalian cell and tissue extracts with very low telomerase activity levels. Unfortunately, conventional TRAP assays require complex post-amplification procedures, such as polyacrylamide gel electrophoresis and densitometry, to measure telomerase products. Therefore, a real-time quantitative TRAP assay (RQ-TRAP) was optimized in the present study and evaluated in comparison with a commercially available quantitative TRAP kit and by monitoring telomerase activity in human hepatocyte cultures, human hepatoma cell lines and telomerase reconstitution experiments. The novel real-time telomerase detection method has many advantages. Other than sample extraction and real-time cycling, no additional time-consuming steps have to be performed for telomerase quantification; reliable and linear telomerase quantification is possible down to single-cell dilutions without the interference of primer-dimer artifacts, and the costs are less. Moreover, the precision is similar to other amplification-based telomerase quantification assays and the results are comparable to data obtained with two commercially available assays. The closed-tube system reduces the risk of carryover contamination and supports high throughput. In conclusion, RQ-TRAP provides a new tool for the rapid and reliable quantification of telomerase activity.
Check Point Firewall-1 Administration Guide (1999)

From the Publisher:
Only complete guide to Check Point FireWall-1,the security software used in 75% of corporate networks worldwide. Clear,step-by-step help for installing,administrating,troubleshooting,and maintaining Check Point firewalls. Officially endorsed and tech edited by Check Point. 
Valuable CD-ROM,created in cooperation with Check Point,contains the most useful set of Firewall-1 tools and utilities available anywhere. 
Your Indispensable Guide to Installing and Maintaining Check Point FireWall-1
Check Point Systems,the leader in security solutions and perimeter protection,has created the #1 firewall used in most corporate networks worldwide. If you are an engineer or network administrator,you know how difficult it is to find the facts you need to implement this new technologyand you don't have the time to search through manuals and documentation. With this unique guide,you can find the most current and comprehensive information on Check Point's FireWall-1all in a single volume. 
The authors clearly explain the underlying concepts of protection that all security professional should know. Using a hands-on approach,the authors guide you through the complex process of designing,building,and maintaining firewalls using Check Point's FireWall-1. 
Check Point FireWall-1 Administration Guide covers three key aspects of this product:

FireWall-1 Overview & Configuration,covering firewall technologies,Check Point's Stateful Inspection and FireWall-1 installation and configuration Fire Wall-1 Administration,discussing all the topics of a security policy,creating objects used in a security policy,some FireWall-1 advanced security features and VirtualPrivate Networking FireWall-1 Advanced Topics,including Check Point's OPSEC standard,fault tolerance,load balancing and advanced general firewall security topics 


Throughout the book,extensive case studies discuss the many security threats to corporate Intranet and Internet sitesand show you how to avoid them using FireWall-1. You'll also find an invaluable CD_ROM that contains an evaluation copy of Check Points's FireWall-1 product,so you can see the benefits of this great product for yourself. 
Check Point FireWall-1 Administration Guide is ideal for administrators and professionals who need to install FireWall-1 for Windows and UNIX. It is the single most up-to-date resource for the latest information on firewall security.
Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer (2003)

Background. YKL-40, a member of family 18 glycosyl hydrolases, is secreted by cancer cells. The function of YKL-40 in cancer diseases is unknown, but it is a growth factor of connective tissue cells and probably has a role in inflammation and remodeling of the extracellular matrix, a process also involved in metastatic malignant diseases. High serum YKL-40 has been associated with poor prognosis for patients with colorectal and recurrent breast cancer. Aim of the study. The purpose of the present study was to examine the prognostic value of plasma YKL-40 in patients presenting with recurring ovarian cancer. Methods. YKL-40 was determined by ELISA in plasma samples from 73 patients with relapse of ovarian cancer shortly before start of second-line chemotherapy. The endpoint used was death because of ovarian cancer. Results. Plasma YKL-40 was increased in ovarian cancer patients (median 94 µg/L, range 20–1970 µg/L) compared with age-matched controls (33 µg/L, range 20–130 µg/L) (p < 0.001). Fifty-five per cent of the patients had a plasma YKL-40 level above the upper normal 95th percentile of controls. Patients with high plasma YKL-40 (i.e. > 130 µg/L or > 160 µg/L) at the time of relapse had significantly shorter survival than patients with normal levels (respectively p = 0.007 and p = 0.004). Plasma YKL-40 proved to be an independent prognostic factor in a multivariate Cox analysis (YKL-40 > 160 µg/L; HR = 2.27) (p = 0.006), including serum CA-125 and clinical/histological parameters. Conclusion. High plasma YKL-40 is related to short survival in patients with recurrent ovarian cancer.
A sthma : Mechanisms of Disease Persistence and Progression (2004)

When asthma is diagnosed, eosinophilic inflammation and airway remodeling are established in the bronchial airways and can no longer be separated as cause and effect because both processes contribute to persistence and progression of disease, despite anti-inflammatory therapy. Th2 cells are continually active in the airways, even when disease is quiescent. IL-13 is the key effector cytokine in asthma and stimulates airway fibrosis through the action of matrix metalloproteinases on TGF-beta and promotes epithelial damage, mucus production, and eosinophilia. The production of IL-13 and other Th2 cytokines by non-T cells augments the inflammatory response. Inflammation is amplified by local responses of the epithelium, smooth muscle, and fibroblasts through the production of chemokines, cytokines, and proteases. Injured cells produce adenosine that enhances IL-13 production. We review human and animal data detailing the cellular and molecular interactions in established allergic asthma that promote persistent disease, amplify inflammation, and, in turn, cause disease progression.
Transchromosomal Mouse Embryonic Stem Cell Lines and Chimeric Mice That Contain Freely Segregating Segments of Human Chromosome 21 (1999)

At least 8% of all human conceptions have major chromosome abnormalities and the frequency of chromosomal syndromes in newborns is >0.5%. Despite these disorders making a large contribution to human morbidity and mortality, we have little understanding of their aetiology and little molecular data on the importance of gene dosage to mammalian cells. Trisomy 21, which results in Down syndrome (DS), is the most frequent aneuploidy in humans (1 in 600 live births, up to 1 in 150 pregnancies world-wide) and is the most common known genetic cause of mental retardation. To investigate the molecular genetics of DS, we report here the creation of mice that carry different human chromosome 21 (Hsa21) fragments as a freely segregating extra chromosome. To produce these 'transchromosomal' animals, we placed a selectable marker into Hsa21 and transferred the chromosome from a human somatic cell line into mouse embryonic stem (ES) cells using irradiation microcell-mediated chromosome transfer (XMMCT). 'Transchromosomal' ES cells containing different Hsa21 regions ranging in size from approximately 50 to approximately 0.2 Mb have been used to create chimeric mice. These mice maintain Hsa21 sequences and express Hsa21 genes in multiple tissues. This novel use of the XMMCT protocol is applicable to investigations requiring the transfer of large chromosomal regions into ES or other cells and, in particular, the modelling of DS and other human aneuploidy syndromes.
An Investigation of the Intrinsic Force Sensing Capabilities of Continuum Robots (2008)

This paper presents the theoretical analysis and the experimental validation of the force sensing capabilities of continuum robots. These robots employ superelastic NiTi backbones and actuation redundancy. The paper uses screw theory to analyze the limitations and provide geometric interpretation to the sensible wrenches. The analysis is based on the singular value decomposition of the Jacobian mapping between the configuration space and the twist space of the end effector. The results show that the sensible wrenches belong to a 2-D screw system and the insensible wrenches belong to a 4-D screw system. The theory presented in this paper is validated through simulations and experiments. It is shown that the force sensing errors have an average of 0.34 g with a standard deviation of 0.83 g. Another experiment of generating the stiffness map of a silicone strip suggests possible medical application of palpation for tumor detection. The presented study allows force sensing in challenging environments where placing force sensors at the distal end of a robot is not possible due to limitations such as size and MRI compatibility.
Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib (2011)

Our findings indicate that the simultaneous use of NVP-BEZ235 and sorafenib has greater antitumor benefit compared to either drug alone and thus provides a treatment strategy in RCC.
Effect of Diet on Obesity of Yellow Mice in Inbred Lines. (1951)

1. The observation has been confirmed that yellow mice on continued inbreeding no longer become obese if maintained under the usual laboratory conditions. 2. Feeding a diet of the “synthetic” type made it possible to induce obesity in the yellow mice but not in their non—yellow litter—mates. 3. The obese yellow mice were observed to have fatty livers. Two of these animals were found to have liver tumors.
Transesterification (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTransesterificationJunzo. OteraCite this: Chem. Rev. 1993, 93, 4, 1449–1470Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/cr00020a004https://doi.org/10.1021/cr00020a004research-articleACS PublicationsRequest reuse permissionsArticle Views18473Altmetric-Citations809LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts