gebhart/patrepeval huggingface dataset:
Selective Laser Sintering of Bio-Metal Scaffold (2013)

This study presents a fabrication process of bone scaffold model with titanium biomedical materials by rapid prototyping (RP) technique. A RP machine with Nd:YAG laser (120W) was developed to produce bone scaffolds using a selective laser sintering (SLS) technology. The slurry state of biomedical material consists of titanium powder and silica sol mixed at 2 g: 1 g weight ratio was used in the proposed process. This biomedical titanium slurry was solidified after scanning by a laser beam. The process parameters of laser were tuned at a laser power of 15W, a frequency of 16KHz and a scanning speed of 100 mm/s to build the titanium biomedical bone model within 3 hrs. Experimental results show that the compressive strength was 142 MPa after post treatment at 900. The mechanical strength of these titanium biomedical material specimens by post sintering process is enhanced. Using this RP machine of layer additive processing, a bone scaffold with complex shape structure can be constructed. Therefore, this process has a greater potential for fabrication bio-metal bone scaffold in tissue engineering.
Cuda Programming: A Developer's Guide to Parallel Computing with Gpus (2012)

If you need to learn CUDA but don't have experience with parallel computing, CUDA Programming: A Developer's Introduction offers a detailed guide to CUDA with a grounding in parallel fundamentals. It starts by introducing CUDA and bringing you up to speed on GPU parallelism and hardware, then delving into CUDA installation. Chapters on core concepts including threads, blocks, grids, and memory focus on both parallel and CUDA-specific issues. Later, the book demonstrates CUDA in practice for optimizing applications, adjusting to new hardware, and solving common problems.



Comprehensive introduction to parallel programming with CUDA, for readers new to both
Detailed instructions help readers optimize the CUDA software development kit
Practical techniques illustrate working with memory, threads, algorithms, resources, and more
Covers CUDA on multiple hardware platforms: Mac, Linux and Windows with several NVIDIA chipsets
Each chapter includes exercises to test reader knowledge

Table of Contents


A Short History of Supercomputing
Understanding Parallelism with GPUs
CUDA Hardware Overview
Setting Up Cuda
Grids, Blocks, and Threads
Memory Handling with CUDA
Using CUDA in Practice
Multi-CPU and Multi-GPU Solutions
Optimizing Your Application
Libraries and SDK
Designing GPU-Based Systems
Common Problems, Causes, and Solutions
Alpha Power Increase After Transcranial Alternating Current Stimulation at Alpha Frequency (α-tACS) Reflects Plastic Changes Rather Than Entrainment (2014)

Our results indicate that plasticity mechanisms are sufficient to explain α-aftereffects in response to α-tACS, and inform models of tACS-induced plasticity in oscillatory circuits. Modifying brain oscillations with tACS holds promise for clinical applications in disorders involving abnormal neural synchrony.
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia (2004)

We report for the first time the use of a selective small-molecule inhibitor of DNA repair to potentiate topoisomerase II (topo II) poisons, identifying DNA-dependent protein kinase (DNA-PK) as a potential target for leukemia therapy. Topo II poisons form cleavable complexes that are processed to DNA double-strand breaks (DSBs). DNA-PK mediates nonhomologous end joining (NHEJ). Inhibition of this DSB repair pathway may sensitize cells to topo II poisons. We investigated the effects of a novel DNA-PK inhibitor, NU7026 (2-(morpholin-4-yl)-benzo[h]chomen-4-one), on the response to topo II poisons using K562 leukemia cells. NU7026 (10 microM) potentiated the growth inhibition of idarubicin, daunorubicin, doxorubicin, etoposide, amsacrine (mAMSA), and mitroxantrone with potentiation factors at 50% growth inhibition ranging from approximately 19 for mAMSA to approximately 2 for idarubicin (potentiation of etoposide was confirmed by clonogenic assay). In contrast, NU7026 did not potentiate camptothecin or cytosine arabinoside (araC). NU7026 did not affect the levels of etoposide-induced topo IIalpha or beta cleavable complexes. NU7026 alone had no effect on cell cycle distribution, but etoposide-induced accumulation in G2/M was increased by NU7026. A concentration-dependent increase in etoposide-induced DSB levels was increased by NU7026. The mechanism of NU7026 potentiation of topo II poisons involves inhibition of NHEJ and a G2/M checkpoint arrest.
Multiplex PCR assay for simultaneous detection and differentiation ofMycobacterium tuberculosis,Mycobacterium aviumcomplexes and other Mycobacterial species directly from clinical specimens (2009)

The triplex PCR developed by us could be used to detect and differentiate M. tuberculosis, M. avium and other mycobacteria in a single reaction tube.
Stepwise synthesis of oligopeptides with N-carboxy-.alpha.-amino acid anhydrides. IV. N-Carboxyglycine anhydride (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStepwise synthesis of oligopeptides with N-carboxy-.alpha.-amino acid anhydrides. IV. N-Carboxyglycine anhydrideRyoichi Katakai, Masanao Oya, Keikichi Uno, and Yoshio IwakuraCite this: J. Org. Chem. 1972, 37, 2, 327–329Publication Date (Print):January 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972https://pubs.acs.org/doi/10.1021/jo00967a036https://doi.org/10.1021/jo00967a036research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T4 Endonuclease Involved in Repair of DNA (1970)

An enzyme activity, named T4 endonuclease V, was purified from T4-infected Escherichia coli. The enzyme induces single-stranded breaks in ultraviolet-irradiated DNA but does not act on native or heat-denatured DNA. The enzyme activity is dependent on the dose of ultraviolet irradiation, and the number of the breaks formed is approximately equal to the number of pyrimidine dimers present in the DNA. Denatured DNA, which has been exposed to ultraviolet light, is also attacked by the enzyme although the extent of the reaction is greater with irradiated native DNA. The enzyme shows optimal activity at pH 7.5 and does not require added divalent ions. When the enzyme-treated, irradiated DNA is subjected to stepwise degradation by spleen phosphodiesterase, dimers are released more rapidly than thymine into the acid-soluble fraction, suggesting that the enzyme induces a break at the 5'-side of a pyrimidine dimer. The enzyme, whose formation is controlled by the v(+) gene of T4, appears to be responsible for the first step of excision repair.
Consensus Conference: Colorectal Cancer Screening and Surveillance in Inflammatory Bowel Disease (2005)

The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn's colitis, are associated with an increased risk for developing colorectal cancer. To reduce colorectal cancer mortality in inflammatory bowel disease, most patients and their physicians choose to follow a program of surveillance colonoscopy in an attempt to detect early neoplastic lesions at a curable stage. Colectomy is typically reserved for patients whose biopsy findings are indicative of heightened cancer risk based on interpretation by pathologists. Despite the absence of prospective controlled clinical trials to formally evaluate the benefits, risks, and costs of this approach, enough circumstantial evidence has accrued to warrant its widespread adoption in practice. Nevertheless, no standardized guidelines have yet been set forth to guide the gastroenterologist in performing surveillance. A panel of international experts was assembled to develop consensus recommendations for the performance of surveillance. The findings are presented herein.
3D Object Recognition with Deep Belief Nets (2009)

We introduce a new type of top-level model for Deep Belief Nets and evaluate it on a 3D object recognition task. The top-level model is a third-order Boltzmann machine, trained using a hybrid algorithm that combines both generative and discriminative gradients. Performance is evaluated on the NORB database (normalized-uniform version), which contains stereo-pair images of objects under different lighting conditions and viewpoints. Our model achieves 6.5 % error on the test set, which is close to the best published result for NORB (5.9%) using a convolutional neural net that has built-in knowledge of translation invariance. It substantially outperforms shallow models such as SVMs (11.6%). DBNs are especially suited for semi-supervised learning, and to demonstrate this we consider a modified version of the NORB recognition task in which additional unlabeled images are created by applying small translations to the images in the database. With the extra unlabeled data (and the same amount of labeled data as before), our model achieves 5.2 % error. 1
RNA helicase A interacts with nuclear factor κB p65 and functions as a transcriptional coactivator (2004)

RNA helicase A (RHA), a member of DNA and RNA helicase family containing ATPase activity, is involved in many steps of gene expression such as transcription and mRNA export. RHA has been reported to bind directly to the transcriptional coactivator, CREB-binding protein, and the tumor suppressor protein, BRCA1, and links them to RNA Polymerase II holoenzyme complex. Using yeast two-hybrid screening, we have identified RHA as an interacting molecule of the p65 subunit of nuclear factor kappaB (NF-kappaB). The interaction between p65 and RHA was confirmed by glutathione-S transferase pull-down assay in vitro, and by co-immunoprecipitation assay in vivo. In transient transfection assays, RHA enhanced NF-kappaB dependent reporter gene expression induced by p65, tumor necrosis factor-alpha, or NF-kappaB inducing kinase. The mutant form of RHA lacking ATP-binding activity inhibited NF-kappaB dependent reporter gene expression induced by these activators. Moreover, depletion of RHA using short interfering RNA reduced the NF-kappaB dependent transactivation. These data suggest that RHA is an essential component of the transactivation complex by mediating the transcriptional activity of NF-kappaB.
Synthesis and Accumulation of Calmodulin in Suspension Cultures of Carrot (Daucus carota L.) (1992)

The expression of calmodulin mRNA and protein were measured during a growth cycle of carrot (Daucus carota L.) cells grown in suspension culture. A full-length carrot calmodulin cDNA clone isolated from a lambdagt10 library was used to measure steady-state calmodulin mRNA levels. During the exponential phase of culture growth when mitotic activity and oxidative respiration rates were maximal, calmodulin mRNA levels were 4- to 5-fold higher than they were during the later stages of culture growth, when respiration rates were lower and growth was primarily by cell expansion. Net calmodulin polypeptide synthesis, as measured by pulse-labeling in vivo with [(35)S]methionine, paralleled the changes in calmodulin steady-state mRNA level during culture growth. As a consequence, net calmodulin polypeptide synthesis declined 5- to 10-fold during the later stages of culture growth. The qualitative spectrum of polypeptides synthesized and accumulated by the carrot cells during the course of a culture cycle, however, remained largely unchanged. Calmodulin polypeptide levels, in contrast to its net synthesis, remained relatively constant during the exponential phases of the culture growth cycle and increased during the later stages of culture growth. Our data are consistent with increased calmodulin polypeptide turnover associated with periods of rapid cell proliferation and high levels of respiration.
The effects of cardiovascular drugs on exercise performance (1988)

1Associate Professor, Department of Medicine; Director, Hypertension Unit, University of Connecticut School of Medicine, Farmington, Connecticut 2Omnicare Marmora, Plaza 9, South Shore Road, Marmora, New Jersey (Formerly) Instructor of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut
Concurrent evaluation of novel cardiac biomarkers in acute coronary syndrome: myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic events in TACTICS-TIMI 18 (2008)

MPO adds to BNP and cTnI for short-term risk assessment for recurrent ischaemic events in non-ST elevation ACS. sCD40L was not associated with risk in this population treated with a platelet GPIIb/IIIa receptor antagonist.
Biochemical interactions between HIV‐1 integrase and reverse transcriptase (2012)

Human immunodeficiency virus (HIV) infection yields a high level of non-integrated viral DNA in the infected cells and up to 99% of total viral DNA can be capable of transcription. This capability of non-integrated viral DNA is reducing the efficacy of anti-HIV drug development approaches that solely focus on the integration reactions of viral replication. Using kinetic modeling, we show the transient coordinated regulation of viral DNA production by retrovirus-encoded interacting enzymes reverse transcriptase (RT) and integrase (IN), and thus we identify a possible mechanism for reducing overall efficiency of viral replication. The results indicate that both IN·RT and IN·DNA complexes and their formation rates affect RT processivity and thereby the viral DNA expression level within the pre-integration complex.
RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase (1998)

Through specific interactions with members of the tumor necrosis receptor (TNFR) family, adapter molecules such as the serine/threonine (Ser/Thr) kinase RIP mediate divergent signaling pathways including NF-kappaB activation and cell death. In this study, we have identified and characterized a novel 61-kDa protein kinase related to RIP that is a component of both the TNFR-1 and the CD40 signaling complexes. Receptor interacting protein-2 (RIP2) contains an N-terminal domain with homology to Ser/Thr kinases and a C-terminal caspase activation and recruitment domain (CARD), a homophilic interaction motif that mediates the recruitment of caspase death proteases. Overexpression of RIP2 signaled both NF-kappaB activation and cell death. Mutational analysis revealed the pro-apoptotic function of RIP2 to be restricted to its C-terminal CARD domain, whereas the intact molecule was necessary for NF-kappaB activation. RIP2 interacted with other members of the TNFR-1 signaling complex, including inhibitor of apoptosis protein cIAP1 and with members of the TNFR-associated factor (TRAF) family, specifically TRAF1, TRAF5, and TRAF6, but not with TRAF2, TRAF3, or TRAF4. These TRAF interactions mediate the recruitment of RIP2 to receptor signaling complexes.
Switchable Transparency and Wetting of Elastomeric Smart Windows (2010)

Elastomeric smart windows with switchable optical transparency and wetting properties (see Fig.) are fabricated through the combination of replica molding and surface wrinkling. The resulting smart windows, with a surface topography that is tunable via mechanical strain, exhibit not only significant changes in optical transmittance and wetting properties, but also the additional functions of self-cleaning and antireflection. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Photochemistry of triarylsulfonium salts (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of triarylsulfonium saltsJohn L. Dektar and Nigel P. HackerCite this: J. Am. Chem. Soc. 1990, 112, 16, 6004–6015Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/ja00172a015https://doi.org/10.1021/ja00172a015research-articleACS PublicationsRequest reuse permissionsArticle Views3369Altmetric-Citations223LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S‐adenosyl‐L‐methionine: Mg protoporphyrin IX methyltransferase (1994)

The bchM gene of Rhodobacter sphaeroides has been sequenced and then overexpressed in E. coli producing a protein of M(r) approximately. 27,500. Cell-free extracts of the transformed E. coli strain are able to methylate added Mg protoporphyrin, resulting in the formation of Mg protoporphyrin monomethyl ester. The identity of this product was verified by HPLC. The bchM gene product is therefore assigned to the methyltransferase step in bacteriochlorophyll biosynthesis.
Role of oestrogen receptors α and β in immune organ development and in oestrogen‐mediated effects on thymus (2001)

Oestrogens affect the development and regulation of the immune system. To determine the role of oestrogen receptors alpha (ER-alpha) and beta (ER-beta) on the development of the immune system, male ER-alpha (ERKO) and ER-beta (BERKO) mice, as well as alphabeta-double knockout (DERKO) mice, were studied. Deletion of ER-alpha led to hypoplasia of both thymus and spleen. Interestingly, a higher frequency of immature double CD4+ CD8+ thymocytes was found in ER-alpha(-) mice compared with ER-alpha(+) mice. Female oophorectomized BERKO mice given oestradiol (E2) displayed a similar degree of thymic atrophy compared with the wild-type strain but showed only limited involution of thymus cortex and no alteration of thymic CD4/CD8 phenotype expression. Our data demonstrate that expression of ER-alpha, but not ER-beta, is mandatory in males for development of full-size thymus and spleen, whereas expression of ER-beta is required for E2-mediated thymic cortex atrophy and thymocyte phenotype shift in females. A potential background for the above findings may be down-regulated activity in the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in males lacking ER-alpha and suppressed sensitivity of females lacking ER-beta to E2-mediated suppression of IGF-1.
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. (1995)

Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22;q12) translocation. These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI1 or ERG genes, both members of the ETS family of transcription factors. Simple variant chromosomal translocations have been occasionally described in these tumors. We have identified a third Ewing's sarcoma translocation, the t(7;22)(p22;q12), that fuses EWS to the human homologue of the murine ETS gene ER81. This gene, designated ETV1 (for ETS Translocation Variant), is located on chromosome band 7p22. Identical EWS nucleotide sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS domain with sequence specific DNA-binding activity. These findings confirm that the fusion of EWS to different ETS family members can result in a similar tumor phenotype.
Performance analysis of multihop lightwave networks with hot potato routing and distance-age-priorities (1991)

A network is studied in which contention for an outbound link is resolved by assigning to each packet a priority based on its distance to destination and its age (number of misroutes previously suffered). Queueing delay, lost packet performance and network aggregate capacity (saturation throughput) are compared for distance-age prioritization, age-distance prioritization and no prioritization. Results suggest that the lower delay, lower lost packet performance, and high saturation throughputs are offered by distance prioritization. The tails of the probability distribution for the number of hops taken by a representative packet are, however, shorter for age-distance routing. Typical results show that, for a multihop shuffle network with 10240 nodes, the saturation throughput is about 40% higher for distance-age prioritization. For a smaller network with 384 nodes, the improvement falls to 25%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of the tissue-specific promoter of the MUC1 gene (1993)

The 5'-sequences flanking the human MUC1 gene have been analyzed for their ability to direct expression of a reporter gene (the chloramphenicol acetyltransferase gene (CAT)) in cell lines that normally express or do not express the MUC1 gene. A construct containing 2.9 kilobase pairs of MUC1 5'-flanking sequence sequence showed expression of CAT in breast and pancreatic cell lines but not in the non-epithelial cell lines HT-1080, SK23, and HTB96. Deletion analysis showed that maximum expression was obtained in ZR-75 (breast cancer line) and HPAF (pancreatic cancer line) with only 743 base pairs of 5'-flanking sequence. Sequences within 1.6 kilobase pairs of the transcriptional start site showed enhancing activity in a vector carrying an enhancerless SV40 promoter. Analysis of proximal 5'-sequences in a promoterless CAT vector carrying the SV40 enhancer showed that sequences between -60 and -150 were crucial for tissue-specific expression. An Sp1 site at -99/-90 and an E box (E-MUC1) at -84/-64 in this region were shown by mutational analysis to play a role in the regulation of transcription. Gel shift analysis with oligonucleotides and nuclear extracts of ZR-75 showed protein binding to both of these sites. Sp1 binding activity was similar in ZR-75 and HT1080 cells, whereas binding of factors to the E-MUC1 oligonucleotide revealed quantitative and qualitative differences between epithelial and non-epithelial cells.