gebhart/patrepeval huggingface dataset:
RAPID LETHAL EFFECT IN RATS OF A THIRD COMPONENT FOUND UPON FRACTIONATING THE TOXIN OF BACILLUS ANTHRACIS (1962)

Beall, Francis A. (U.S. Army Chemical Corps, Frederick, Md.), Martha J. Taylor, and Curtis B. Thorne. Rapid lethal effect in rats of a third component found upon fractionating the toxin of Bacillus anthracis. J. Bacteriol. 83:1274-1280. 1962.-Rats were found to be more susceptible to the lethal effect of toxin produced by Bacillus anthracis in vitro than were several species considered less resistant to anthrax. Rats were killed much faster by less toxin per gram of body weight than were mice. Guinea pigs survived doses of toxin that killed rats. Intravenous injection of Fischer 344 rats is a rapid test for lethal activity, which facilitates the demonstration of two components, different from protective antigen, in toxin. One of these, a lethal factor, was separated from the other component, which causes cutaneous edema in the guinea pig. The latter component was not necessary for lethal effect. Neither of these factors was active unless combined with protective antigen. Although the guinea pig skin reaction has been used routinely to assay the toxicity of samples, the present results show that this test does not assay the lethal component.
Mini‐review: The role of peptidoglycan recognition in innate immunity (2004)

The importance of peptidoglycan detection in the host innate immune response has long been underestimated. However, the recent identification of proteins involved in the sensing of peptidoglycan in both mammals and Drosophila has revealed that the detection of this microbial motif is key to the defense response. In Drosophila, the peptidoglycan-recognition proteins (PGRP) are the initial sensors of infecting bacteria that then trigger a cascade ultimately leading to the expression of antimicrobial peptides. In mammals, PGRP also exist and although they bind peptidoglycan, the role of these proteins in innate immune responses remains to be clearly defined. In contrast, the Nod proteins (Nod1 and Nod2), which are also involved in peptidoglycan sensing, appear to play a key role in innate immunity against bacteria by triggering host defense responses through the activation of the transcription factor, NF-kappaB. Interestingly, mutations in Nod2 are related to increased susceptibility to Crohn's disease, thereby implicating defective bacterial sensing in the development at this chronic disease. In this review, we will focus on the recent findings concerning mammalian and Drosophila proteins involved in peptidoglycan recognition and the putative role of these proteins in the innate immune defense response.
Telomeres, Telomerase, and Immortality (1995)

A current hypothesis gaining prominence proposes that activation of the enzyme telomerase is necessary for cells to become immortal, or capable of proliferating indefinitely. The theory suggests that almost all cancer cells must attain immortality for progression to malignant states and, hence, require activation of telomerase. This article reviews the function and formation of telomeres as background to evaluating the "telomere hypothesis." Experiments in support of and experiments that challenge the hypothesis are examined. Possible approaches to telomerase inhibition are discussed.
Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast (2007)

Proteomic analyses in yeast have identified a large number of proteins that are associated with preribosomal particles. However, the product of the yeast ORF YJL010C, herein designated as Nop9, failed to be identified in any previous physical or genetic analysis of preribosomes. Here we report that Nop9 is a nucleolar protein, which is associated with 90S and 40S preribosomes. In cells depleted of Nop9p, early cleavages of the 35S pre-rRNA are inhibited, resulting in the nucleolar retention of accumulated precursors and a failure to synthesize 18S rRNA. Nop9 contains multiple pumilio-like putative RNA binding repeats and displays robust in vitro RNA binding activity. The identification of Nop9p as a novel, essential factor in the nuclear maturation of 90S and pre-40S ribosomal subunits shows that the complement of ribosome synthesis factors remains incomplete.
Coulomb Blockade and Hopping Conduction in PbSe Quantum Dots (2005)

We report for the first time on rich and tunable transport phenomena in closed-packed arrays of PbSe colloidal nanocrystals (NCs) in the form of thin films. As the interdot coupling is increased, the system evolves from an insulating regime dominated by Coulomb blockade to a semiconducting regime, where hopping conduction is the dominant transport mechanism. The observed phenomena can be interpreted using the framework established mainly in the context of transport measurements in metallic quantum dots and disordered semiconductors.
MT-103 Micromet/MedImmune. (2006)

Micromet AG and Medlmmune Inc are developing MT-103, a single-chain bispecific recombinant antibody from Micromet's BiTE (bispecific T-cell engager) product platform that binds both the CD19 antigen and the T-cell receptor (CD3), for the potential treatment of B-cell lymphoma. The company is also investigating the compound for the potential treatment of chronic lymphocytic leukemia and acute lymphoblastic leukemia.
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord (2015)

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-tDNA. We analyzed 35 primary CNS malignancies and found at least one mutation in each tumor using targeted or genome-wide sequencing. Using these patient-specific mutations as biomarkers, we identified detectable levels of CSF-tDNA in 74% [95% confidence interval (95% CI) = 57-88%] of cases. All medulloblastomas, ependymomas, and high-grade gliomas that abutted a CSF space were detectable (100% of 21 cases; 95% CI = 88-100%), whereas no CSF-tDNA was detected in patients whose tumors were not directly adjacent to a CSF reservoir (P < 0.0001, Fisher's exact test). These results suggest that CSF-tDNA could be useful for the management of patients with primary tumors of the brain or spinal cord.
Petri Net-Based Scheduling of Single-Arm Cluster Tools With Reentrant Atomic Layer Deposition Processes (2010)

For some wafer fabrication processes in cluster tools, e.g., atomic layer deposition (ALD), wafer revisiting is required. Typically, in such processes, wafers need to visit two consecutive processing steps several times. Such a revisiting process can be denoted as (mi, mi + 1) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">h</sup> , where i means the ith-step and m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> and m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i + 1</sub> mean the corresponding quantity of the processing modules in i and (i+1)th steps, and h the number of visiting times. This paper conducts a study for scheduling single-arm cluster tools with such a wafer revisiting process. The system is modeled by Petri nets (PNs) to guarantee the feasibility of robot activities. Based on the model, a deadlock avoidance policy is presented. With the control policy, cycle time analysis for the revisiting process is made. With the fact that wafer processing times are much longer than robot movement times in cluster tools, it is shown that, when m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> = m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i + 1</sub> = 1, i.e., each step has only one processing module, the optimal one-wafer cyclic schedule is deterministic and unique, and the minimal cycle time can be calculated by an analytical expression. It is also shown that, when m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> = 1 and m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> + 1 = 2 or m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> = 2 and m <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> + 1 = 1, the optimal one-wafer cyclic schedule can be obtained by finding h deterministic schedules and the one with the least cycle time. A novel analytical method is finally presented to schedule the overall system containing such reentrant wafer flow. This represents a significant advance in single-arm cluster equipment automation.
Efficiency of Lignin Biosynthesis: a Quantitative Analysis (2003)

Lignin is derived mainly from three alcohol monomers: p-coumaryl alcohol, coniferyl alcohol and sinapyl alcohol. Biochemical reactions probably responsible for synthesizing these three monomers from sucrose, and then polymerizing the monomers into lignin, were analysed to estimate the amount of sucrose required to produce a unit of lignin. Included in the calculations were amounts of respiration required to provide NADPH (from NADP(+)) and ATP (from ADP) for lignin biosynthesis. Two pathways in the middle stage of monomer biosynthesis were considered: one via tyrosine (found in monocots) and the other via phenylalanine (found in all plants). If lignin biosynthesis proceeds with high efficiency via tyrosine, 76.9, 70.4 and 64.3 % of the carbon in sucrose can be retained in the fraction of lignin derived from p-coumaryl alcohol, coniferyl alcohol and sinapyl alcohol, respectively. The corresponding carbon retention values for lignin biosynthesis via phenylalanine are less, at 73.2, 65.7 and 60.7 %, respectively. Energy (i.e. heat of combustion) retention during lignin biosynthesis via tyrosine could be as high as 81.6, 74.5 and 67.8 % for lignin derived from p-coumaryl alcohol, coniferyl alcohol and sinapyl alcohol, respectively, with the corresponding potential energy retention values for lignin biosynthesis via phenylalanine being less, at 77.7, 69.5 and 63.9 %, respectively. Whether maximum efficiency occurs in situ is unclear, but these values are targets that can be considered in: (1) plant breeding programmes aimed at maximizing carbon or energy retention from photosynthate; (2) analyses of (minimum) metabolic costs of responding to environmental change or pest attack involving increased lignin biosynthesis; (3) understanding costs of lignification in older tissues; and (4) interpreting carbon balance measurements of organs and plants with large lignin concentrations.
Essential role of the HMG domain in the function of yeast mitochondrial histone HM: functional complementation of HM by the nuclear nonhistone protein NHP6A. (1993)

The yeast mitochondrial histone protein HM is required for maintenance of the mitochondrial genome, and disruption of the gene encoding HM (HIM1/ABF2) results in formation of a respiration-deficient petite mutant phenotype. HM contains two homologous regions, which share sequence similarity with the eukaryotic nuclear nonhistone protein, HMG-1. Experiments with various deletion mutants of HM show that a single HMG domain of HM is functional and can restore respiration competency to cells that lack HM protein (him1 mutant cells). The gene encoding the putative yeast nuclear HMG-1 homolog, the NHP6A protein, can functionally complement the him1 mutation. These results suggest that the HMG domain is the basic unit for the function of HM in mitochondria and that the function of HMG-1 proteins in the nucleus and HM in the mitochondrion may be equivalent.
A DNA Sequence Required for Geminivirus Replication Also Mediates Transcriptional Regulation (1994)

Patricia A. Eagle, Beverly M. Orozco, Linda Hanley-Bowdoin, A DNA Sequence Required for Geminivirus Replication Also Mediates Transcriptional Regulation, The Plant Cell, Vol. 6, No. 8 (Aug., 1994), pp. 1157-1170
“Burns” Occurring During Lengthy Surgical Procedures (1980)

Accidental burns or burn-like injuries continue to occur during lengthy surgical procedures. Many remain unexplained as to the cause. The threat of litigation suppresses discussion of the incidence of injuries of this type -- which are not uncommon. The same threat appears to have suppressed wider discussion of potential solutions. Many of these burn-like injuries are not burns but pressure sores, and as such are preventable. Strategies for reducing the numbers of injuries of this type are discussed.
Axial capacity of reactive powder concrete filled steel tube columns with two load conditions (2019)

Reactive powder concrete (RPC) is a type of ultra-high strength concrete that has a relatively high brittleness. However, its ductility can be improved by confinement, and the use of RPC in composite RPC filled steel tube columns has become an important subject of research in recent years. This paper aims to present an experimental study of axial capacity calculation of RPC filled circular steel tube columns. Twenty short columns under axial compression were tested and information on their failure patterns, deformation performance, confinement mechanism and load capacity were presented. The effects of load conditions, diameter-thickness ratio and compressive strength of RPC on the axial behavior were further discussed. The experimental results show that: (1) specimens display drum-shaped failure or shear failure respectively with different confinement coefficients, and the load capacity of most specimens increases after the peak load; (2) the steel tube only provides lateral confinement in the elastic-plastic stage for fully loaded specimens, while the confinement effect from steel tube initials at the set of loading for partially loaded specimens; (3) confinement increases the load capacity of specimens by 3% to 38%, and this increase is more pronounced as the confinement coefficient becomes larger; (4) the residual capacity-to-ultimate capacity ratio is larger than 0.75 for test specimens, thus identifying the composite columns have good ductility. The working mechanism and force model of the composite columns were analyzed, and based on the twin-shear unified strength theory, calculation methods of axial capacity for columns with two load conditions were established.
Handbook of Pharmaceutical Additives (2002)

Handbook of pharmaceutical additives , Handbook of pharmaceutical additives , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Use of Lamotrigine in Lennox-Gastaut and Related Epilepsy Syndromes (1997)

Lennox-Gastaut syndrome a combination of various generalized seizures including atypical absences and tonic seizures with generalized slow spike waves and mental deterioration, is often difficult to distinguish from a subgroup of myoclonic-astatic epilepsy, other generalized epilepsy syndromes, and various symptomatic generalized epilepsies. Conventional antiepileptic medication is poorly effective in this condition, particularly because various types of seizures respond differently to each given drug. Lamotrigine is effective in the various types of generalized seizures and efficacy has been demonstrated in Lennox-Gastaut syndrome. Given the potential of major mental deterioration within a matter of months in this condition, and the need of slow dose escalation in order to prevent skin rash, lamotrigine should be administered as soon as the diagnosis of Lennox-Gastaut syndrome is suspected. In addition, there is growing evidence that lamotrigine is also most useful in the subgroup of myoclonic-astatic epilepsy beginning in childhood, and that these patients should benefit from the drug like those affected by Lennox-Gastaut syndrome, as soon as the diagnosis is suspected. However, this drug may worsen other cases of myoclonic-astatic epilepsy beginning in infancy. These clinical observations add to the evidence for the need of clear diagnostic work-up before appropriate drug therapy is decided in pediatric epilepsy.
Hierarchical structural approach to improving the browsability of Web search engine results (2002)

Web users have been mainly relying on Web search engines to find information of interest on the Web. However, two key issues remain with traditional Web search engines: the browsability of searching results and the capacity of Web coverage. The long ranked list presentation of search results, which is widely adopted by the industry adds a layer of confusion to users, especially when the number of matches returned from search engines can easily exceed ten thousand level. We designed an agent system based on hierarchically structural approach for organizing Web search results coupled with a metasearch approach for Web searching. The metasearch approach would help us extract the best of the Web from a larger Web coverage; and our ontological approach is aimed at providing a mechanism to categorize search results in a semantic hierarchical organization, and allow users to find target information in a progressive and interactive manner.
The effect of transcutaneous electrical nerve stimulation on blood pressure (2012)

Dear Editor,We read with great interest the article by Silverdal et al. (1), in which they compared the blood pressure (BP) lowering effect of 2.5 mg felodipin once daily with 30 min of bidaily low...
[Type II multiple endocrine neoplasms (MEN IIB): an unusual cause of constipation. A plea for early thyroidectomy]. (1993)

We present a 5 year old girl who was diagnosed to have multiple endocrine neoplasia syndrome type IIB (MEN IIB). She presented with serious constipation and had the distinct features of MEN IIB. 100% of the patients with MEN IIB develop medullary thyreoïd carcinoma (MTC). MTC in MEN IIB is known to behave in a very aggressive way. Microscopically MTC was already present in this patient despite of normal calcitonin stimulation tests. Accordingly we plead for a more radical management relating to thyreoïdectomy in MEN IIB.
Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport (2015)

Ginger is a popular spice used to treat a variety of maladies, including pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used by athletes to manage and prevent pain; unfortunately, NSAIDs contribute to substantial adverse effects, including gastrointestinal (GI) dysfunction, exercise-induced bronchoconstriction, hyponatremia, impairment of connective tissue remodeling, endurance competition withdrawal, and cardiovascular disease. Ginger, however, may act as a promoter of GI integrity and as a bronchodilator. Given these potentially positive effects of ginger, a systematic review of randomized trials was performed to assess the evidence for ginger as an analgesic and ergogenic aid for exercise training and sport. Among 7 studies examining ginger as an analgesic, the evidence indicates that roughly 2 g·d(-1) of ginger may modestly reduce muscle pain stemming from eccentric resistance exercise and prolonged running, particularly if taken for a minimum of 5 days. Among 9 studies examining ginger as an ergogenic aid, no discernable effects on body composition, metabolic rate, oxygen consumption, isometric force generation, or perceived exertion were observed. Limited data suggest that ginger may accelerate recovery of maximal strength after eccentric resistance exercise and reduce the inflammatory response to cardiorespiratory exercise. Major limitations to the research include the use of untrained individuals, insufficient reporting on adverse events, and no direct comparisons with NSAID ingestion. While ginger taken over 1-2 weeks may reduce pain from eccentric resistance exercise and prolonged running, more research is needed to evaluate its safety and efficacy as an analgesic for a wide range of athletic endeavors.
An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells (2010)

The described entirely cell-based technology is a fast and efficient approach for obtaining antibodies reactive with endogenous cell-surface proteins in their native conformation.
MAGNETIC RESONANCE IMAGING (1983)

Runge, V. M.; Johnson, G.; Smith, F. W.; Price, R. R.; Patton, J. A.; James, A. E. Jr. Author Information
Cloning and sequencing of the gene for a Pseudomonas paucimobilis enzyme that cleaves beta-aryl ether (1991)

We isolated Pseudomonas paucimobilis SYK-6, which was able to degrade various dimeric lignin compounds (Y. Katayama, S. Nishikawa, M. Nakamura, K. Yano, M. Yamasaki, N. Morohoshi, and T. Haraguchi, Mokuzai Gakkaishi 33:77-79, 1987). This metabolic process is a distinct characteristic of this bacterium, which is equipped with an enzymatic modification system for various dimeric lignin compounds involved in the tricarboxylic acid cycle. Cleavage of the beta-aryl ether linkage is essential in this process, because this linkage is the most abundant (approximately 50%) in lignin. Here, we report the isolation and characterization of the beta-etherase gene, which contains an open reading frame of 843 bp and which we call ligE. This gene was expressed in Escherichia coli, and the enzyme had the same kinetic properties as the P. paucimobilis SYK-6 enzyme.
Update on the endocannabinoid system as an anticancer target (2011)

One direction that should be pursued in antitumor therapy is to select compounds with reduced psychoactivity. This is known to be connected to the CB1 receptor; thus, targeting the CB2 receptor is a popular objective. CB1 receptors could be maintained as a target to design new compounds, and mixed CB1-CB2 ligands could be effective if they are able to not cross the BBB. Furthermore, targeting the ECS with agents that activate cannabinoid receptors or inhibitors of endogenous degrading systems such as fatty acid amide hydrolase inhibitors may have relevant therapeutic impact on tumor growth. Additional studies into the downstream consequences of endocannabinoid treatment are required and may illuminate other potential therapeutic targets.
Metathesis of unsaturated fatty acids: Synthesis of long‐chain unsaturated‐α,ω‐dicarboxylic acids (2006)

Abstract The self‐metathesis of readily available monounsaturated FA has the potential of being an important pathway for the synthesis of symmetrical long‐chain unsaturated‐α,ω‐dicarboxylic acids (C 18 −C 26 ). Previous studies on the self‐metathesis of monounsaturated FA esters using ruthenium catalysts in solution, however, suffered from low conversions as a result of the thermodynamic control of the reaction. We have found that the second‐generation Grubbs catalyst can effectively catalyze the solvent‐free self‐metathesis of monounsaturated FA of varying purity (from 90 to 99%) to afford two important products—monounsaturated dicarboxylic acids and hydrocarbons—in very high molar conversions (&gt;80%). This solvent‐free self‐metathesis reaction also works for monounsaturated FA containing additional functional groups. Reactions were conducted at catalyst loadings as low as 0.005 mol%, and turnover numbers as high as 10,800 could be obtained. This discovery represents an attractive approach to the large‐scale production of useful monounsaturated‐α,ω‐dicarboxylic acids and long‐chain unsaturated hydrocarbons by means of this solvent‐free ruthenium‐catalyzed self‐metathesis of readily available monounsaturated FA.