gebhart/patrepeval huggingface dataset:
Suppression of Take-All of Wheat by Seed Treatments with Fluorescent Pseudomonads (2008)

Strains of fluorescent <i>Pseudomonas</i> spp. applied to wheat seeds suppressed take-all in both greenhouse- and field-grown winter and spring wheat. The effective strains were originally isolated from roots of wheat grown in soil naturally suppressive to take-all and were selected on the basis of in vitro antibiosis to <i>Gaeumannomyces graminis</i> var. <i>tritici</i>. Isolate 2-79, alone or combined with isolate 13-79, suppressed take-all in five of six field tests conducted in nonfumigated soil infested with inoculum of <i>G. graminis</i> var. <i>tritici</i>. The combination treatment was more suppressive than 13-79 alone in all field tests, and was slightly more suppressive than 2-79 alone in three of six field tests. Suppression of take-all by the bacteria was expressed in the field as fewer plants with foliage symptoms of take-all and taller plants, more heads, greater yield, and less root disease than those grown from nontreated seed. Tests in field plots fumigated with methyl bromide, with and without the reintroduction of <i>G. graminis</i> var. <i>tritici</i>, established that the bacteria do not promote plant growth other than by controlling of take-all. The seed treatment resulted in increased yields of up to 147% in fumigated soil and up to 27% in natural soil. An antibiotic-resistant strain of 2-79 was isolated from the roots of wheat in the field following germination of bacteria-treated seed. The population of the introduced bacterium exceeded 10<sup>6</sup> colony-forming units per 0.1 g of root tissue 3 wk after planting. The populations of strains 2-79 and 13-79 applied on wheat seeds with methylcellulose were stable for 21 days at 5 or 15 C, but declined rapidly at 25 C.
Aminopeptidase A Expression in Cervical Neoplasia and Its Relationship to Neoplastic Transformation and Progression (2000)

Aminopeptidase A (AP-A) is a cell surface metallopeptidase which specifically cleaves the amino-terminal acidic residue from peptide substrates such as angiotensin II. AP-A is identical to the differentiation-related antigen, murine BP-1 or human kidney gp160, and is involved in regulating cell differentiation and/or neoplastic transformation of certain normal and transformed cells. We examined expression of AP-A in premalignant and malignant lesions of the uterine cervix, and investigated whether its expression was related to disease progression and neoplastic transformation. Formalin-fixed, paraffin-embedded tissue sections including 14 cervical intraepithelial neoplasms (CIN) and 23 invasive squamous cell carcinomas (SCC) were immunohistochemically evaluated. AP-A was localized in the basal cell layer in normal squamous epithelium. In CIN, AP-A expression was found on dysplastic cells, and increased with the severity of the precancerous lesions. In invasive cancer, 18 of 19 non-keratinizing-type SCCs and none of 4 keratinizing-type SCCs expressed AP-A. In addition, AP-A immunoreactivity was significantly correlated with proliferating cell nuclear antigen expression in both CIN and SCC cases. Furthermore, angiotensin II type 1 receptor was present in all AP-A-positive SCCs. These results indicate that AP-A is upregulated as the lesion progresses toward carcinoma in the cervical epithelium, and suggest that AP-A may play a regulatory role in neoplastic transformation and disease progression in cervical neoplasms and may serve as a potential tumor marker during cervical neoplasia development.
Complete nucleotide sequence of a French bean storage protein gene: Phaseolin (1983)

The complete nucleotide sequences of the gene and the mRNA coding for a specific phaseolin type French bean major storage protein have been determined. Comparison of these sequences reveals a phaseolin gene structure consisting of 80 base pairs (bp) of 5' untranslated DNA, 1,263 bp of protein-encoding DNA which is interrupted by five intervening sequences (IVS1, 72 bp; IVS2, 88 bp; IVS3, 124 bp; IVS4, 128 bp; and IVS5, 103 bp), and 135 bp of 3' untranslated DNA. Sequences characteristic of eukaryotic promoters "CCAAT" and "TATA" are present in the 5' flanking DNA, and the eukaryotic poly(A) addition signal A-A-T-A-A-A occurs 16 bp before the first nucleotide of poly(A). The derived amino acid sequence yields an amino acid composition and a molecular weight compatible with those found for the beta-type phaseolin protein. Two regions that probably serve as carbohydrate-peptide linkage recognition sites have been identified. A region of highly hydrophobic amino acids at the NH(2) terminus of the protein suggests the presence of a signal peptide in the newly synthesized phaseolin protein.
Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy (2004)

Ovarian cancer is the most frequent cause of cancer death among all gynecologic cancers. We demonstrate here that lysophosphatidic acid (LPA)-induced ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF) is a critical to tumor formation in ovarian cancer. We found that among the epidermal growth factor receptor (EGFR) family of growth factors, HB-EGF gene expression in cancerous tissues and HB-EGF protein levels in patients' ascites fluid were significantly elevated. The human ovarian cancer cell lines SKOV3 and RMG-1 form tumors in nude mice. Tumor formation of these cells was enhanced by exogenous expression of pro-HB-EGF and completely blocked by pro-HB-EGF gene RNA interference or by CRM197, a specific HB-EGF inhibitor. Transfection with mutant forms of HB-EGF indicated that the release of soluble HB-EGF is essential for tumor formation. LPA, which is constitutively produced by ovarian cancer cells, induced HB-EGF ectodomain shedding in SKOV3 and RMG-1 cells, resulting in the transactivation of EGFR and the downstream kinase extracellular signal-regulated kinase/mitogen-activated protein kinase. LPA-induced transactivation was abrogated by HB-EGF gene RNA interference or by CRM197. Introduction of lipid phosphate phosphohydrolase, which hydrolyzes LPA, decreased the constitutive shedding of HB-EGF, EGFR transactivation, and the tumorigenic potential of SKOV3 and RMG-1 cells. These results indicate that HB-EGF is the primary member of the EGFR family of growth factors expressed in ovarian cancer and that LPA-induced ectodomain shedding of this growth factor is a critical step in tumor formation, making HB-EGF a novel therapeutic target for ovarian cancer.
Proposition for the innovation of the rehabilitation medicine (2006)

The priority of Proprioceptive Neuromuscular Facilitation (PNF) to hemiplegic patients on the affected side must be reconsidered due to a lack of effect in its procedure. By the improvement of the theory and techniques of PNF, the improvement of therapeutic effects on hemiplegia patients could be expected in connection with their progress, however the outcome of medical examination has hardly been changed on hemiplegia patients at the clinical aspect over the last 40 years. Although PNF is thought to be more suitable for the normalization of a movement pattern to perform synthetic coordinated movements by affected side priority, it takes too long to lead to the active contraction of the peripheral muscles. Sometimes, even the atrophy of an unaffected side and the trunk can be seen. In considering the PNF of unaffected side priority the effect of facilitation is larger than that of affected side priority. Therefore, if the unaffected priority is used a smaller number of patients will be bedridden by atrophy and contracture. From the recent research on new born power of a neural stem cell (NSC), the elucidation of the mechanism for the effectiveness of the kinetic rehabilitation by the unaffected side priority enables us to expect the functional recovery of a damaged area. The NSC would also affect to the rehabilitation in the realm of the nervous system. It's recommended to try to use and get the evidence of PNF by unaffected side priority.
Block-iterative generalized decision feedback equalizers for large MIMO systems: algorithm design and asymptotic performance analysis (2006)

This paper studies the problem of signal detection for multiple-input multiple-output (MIMO) channels with large signal dimensions. We propose a block-iterative generalized decision feedback equalization (BI-GDFE) receiver to recover the transmitted symbols in a block-iterative manner. By exploiting the input-decision correlation, a measure for the reliability of the earlier-made decisions, we design the feed-forward equalizers (FFEs) and feedback equalizers (FBEs) in such a way that maximized signal-to-interference-plus-noise ratio (SINR) is achieved for each of the iterations. Novel implementations are also introduced to simplify the complexity of the receiver, which requires only one-tap filters for FFE and FBE. The proposed receiver also works when the signal dimension is greater than the observation dimension. The asymptotic performance of the proposed receiver is analyzed and its convergence has been confirmed through numerical evaluations for various parameters. Computer simulations are presented to illustrate the capability of the proposed receiver to achieve single user matched-filter bound (MFB) for large random MIMO channels when the received SNR is high enough.
A new Australian kindred with the syndrome of hypertension and hyperkalaemia has dysregulation of atrial natriuretic factor (1988)

A family with the syndrome of hypertension and hyperkalaemia affecting six members in two generations is reported from Australia, where the first two sporadic cases were described. All family members had hyperkalaemia, hyperchloraemia and normal creatinine clearance. Only one affected adult and no affected children were hypertensive, possibly because of habitual low-salt diets. Plasma potassium fell significantly during fludrocortisone acetate administration, and urine potassium increased during saline infusion, consistent with renal tubular responsiveness to mineralocorticoid. Low plasma renin activity and pressor hyper-responsiveness to angiotensin II suggested sodium volume overload, but atrial natriuretic factor (ANF) was normal or only slightly elevated when compared with clearly elevated levels in primary aldosteronism. Plasma ANF was unresponsive to the usually reliable stimulus of angiotensin infusion in the two brothers affected and to saline infusion in one of them. These findings are consistent with a renal tubular avidity for sodium, leading to volume expansion, suppression of renin, and, depending on dietary sodium intake, hypertension. A role for dysregulation of ANF in the pathophysiology is possible.
Kinetic, Affinity, and Diversity Limits of Human Polyclonal Antibody Responses against Tetanus Toxoid (2007)

Due to technical limitations, little knowledge exists on the composition of Ag-specific polyclonal Ab responses. Hence, we here present a molecular analysis of two representative human Ab repertoires isolated by using a novel single-cell cloning approach. The observed genetic diversity among tetanus toxoid-specific plasma cells indicate that human polyclonal repertoires are limited to the order of 100 B cell clones and hypermutated variants thereof. Affinity and kinetic binding constants are log-normally distributed, and median values are close to the proposed affinity ceilings for positive selection. Abs varied a million-fold in affinity but were restricted in their off-rates with an upper limit of 2 x 10(-3) s(-1). Identification of Abs of high affinity without hypermutations in combination with a modest effect of hypermutations on observed affinity increases indicate that Abs selected from the naive repertoire are not only of low affinity but cover a relatively large span in affinity, reaching into the subnanomolar range.
An evaluation of intrathecal ziconotide for the treatment of chronic pain (2000)

Ziconotide, the synthetic form of cone snail peptide pi-conotoxin MVIIA, is a neurone-specific N-type calcium channel blocker with an analgesic and neuroprotective effect. Intrathecal ziconotide has been recommended for approval by the FDA for the management of chronic pain. Spinally administered ziconotide produces analgesia by blocking neurotransmitter release from primary nociceptive afferents and prevents the propagation of pain signals to the brain. It has an advantage over intrathecal morphine in that there is no development of tolerance after prolonged use. Systemic toxicity is considerably reduced by administration of smaller doses intrathecally and selective delivery to the site of action in the nervous system. Nevertheless, there are neurological adverse effects due to delay in clearance of ziconotide from the neural tissues. Overall, ziconotide has a favourable risk/benefit ratio with advantages over several currently available intrathecal therapies for pain.
Viricidal action of ethylene oxide gas (1954)

Investigation of the viricidal effect of a mixture of ethylene oxide and carbon dioxide on two viruses, Columbia SK and vaccinia, yielded favourable results. Since ethylene oxide also exerts a germicidal effect, it offers simple and inexpensive disinfection of certain materials, especially those of low thermostability.
CD38/CD31, the CCL3 and CCL4 Chemokines, and CD49d/Vascular Cell Adhesion Molecule-1 Are Interchained by Sequential Events Sustaining Chronic Lymphocytic Leukemia Cell Survival (2009)

CD38 and CD49d are associated negative prognosticators in chronic lymphocytic leukemia (CLL). Despite evidence that both molecules are involved in interactions occurring between CLL and normal cells in the context of CLL-involved tissues, a functional link is still missing. Using gene expression profiles comparing CD38(+)CD49d(+) versus CD38(-)CD49d(-) CLL cells, we showed overexpression of the CCL3 and CCL4 chemokines in cells from the former group. These chemokines were also up-regulated by CD38 signals in CLL; moreover, CCL3 was expressed by CLL cells from bone marrow biopsies (BMB) of CD38(+)CD49d(+) but not CD38(-)CD49d(-) cases. High levels of CCR1 and, to a lesser extent, CCR5, the receptors for CCL3 and CCL4, were found in CLL-derived monocyte-macrophages. Consistently, CCL3 increased monocyte migration, and CD68(+) macrophage infiltration was particularly high in BMB from CD38(+)CD49d(+) CLL. Conditioned media from CCL3-stimulated macrophages induced endothelial cells to express vascular cell adhesion molecule-1 (VCAM-1), the CD49d ligand, likely through tumor necrosis factor alpha overproduction. These effects were apparent in BMB from CD38(+)CD49d(+) CLL, where lymphoid infiltrates were characterized by a prominent meshwork of VCAM-1(+) stromal/endothelial cells. Lastly, CD49d engagement by VCAM-1 transfectants increased viability of CD38(+)CD49d(+) CLL cells. Altogether, CD38 and CD49d can be thought of as parts of a consecutive chain of events ultimately leading to improved survival of CLL cells.
Total synthesis of the antitumor antibiotic streptonigrin (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the antitumor antibiotic streptonigrinSteven M. Weinreb, Fatima Z. Basha, Satoshi Hibino, Nazir A. Khatri, Deukjoon Kim, Walter E. Pye, and Tai Teh WuCite this: J. Am. Chem. Soc. 1982, 104, 2, 536–544Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ja00366a028https://doi.org/10.1021/ja00366a028research-articleACS PublicationsRequest reuse permissionsArticle Views880Altmetric-Citations77LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Patterned Functionalization of Gold and Single Crystal Silicon via Photochemical Reaction of Surface-Confined Derivatives of (Eta5-C5H5)MN(CO)3 (1990)

Abstract : Treatment of a single crystal Si wafer (n- or p-type, 100 face) having a thin surface SiO(x) layer with Cl3Si-(eta5-C5H4)Mn(CO)3, I, yields the Si-confined complex (Si)-O-Si-eta5-C5H4)Mn(CO)3. Coverage of about a monolayer is typically achieved. Near-UV irradiation of the Si-confined tricarbonyl in L = PPh2(n-octyl) gives the surface-confined substitution product (Si)-O-Si-eta5- C5H4)Mn(CO)2L. The identities of the Si-confined complexes were determined by comparison of their IR CO stretching frequencies with those of (CH3)3Si-(eta5- C5H4)Mn(CO)2L, and of the corresponding high surface area SiO2-confined species, (SiO2)-O-Si (CH3)2-eta5-C5H4)Mn(CO)2L (L = CO, PPh(n-octyl)). Treatment of a Au- coated Si wafer with HS(CH2)11-eta5-C5H4)Mn(CO)3, II, yields about a monolayer of the Au-confined complex (Au)S(CH2)11-eta5-C5H4)Mn(CO)3. Near-UV irradiation of the Au-confined tricarbonyl in the presence of L = PPh2(n-octyl) yields the surface-confined substitution product (Au)-S(CH2)11-(eta5-C5H4)MN(CO)2L. The photochemistries of surface-confined I and II differ from the photochemistries of the corresponding solution species. Patterning of the surface of a Si wafer modified with I or of Au modified with II is readily accomplished, since photosubstitution occurs only on irradiated portions of the surface.
The Predicament of Culture (1988)

News| December 01 1988 The Predicament of Culture Laura U. Marks Laura U. Marks Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1988) 16 (5): 2. https://doi.org/10.1525/aft.1988.16.5.2 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Laura U. Marks; The Predicament of Culture. Afterimage 1 December 1988; 16 (5): 2. doi: https://doi.org/10.1525/aft.1988.16.5.2 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1988 by The Regents of the University of California1988 Article PDF first page preview Close Modal You do not currently have access to this content.
Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody (1999)

Recombinant humanized antivascular endothelial growth factor (rhuMAbVEGF) is a monoclonal IgG1 antibody that is being developed as an antiangiogenic agent for use in treating a variety of solid tumors. Preclinical safety studies included an immunohistochemical tissue cross-reactivity study, in vitro hemolytic potential and blood compatibility studies, and multiple dose toxicity studies. Toxicity studies were conducted in cynomolgus monkey because rhuMAbVEGF is pharmacologically active in this species and does not bind rat or mouse vascular endothelial growth factor (VEGF). Following twice weekly administration of rhuMAbVEGF for 4 or 13 wk, young adult cynomolgus monkeys exhibited physeal dysplasia characterized by a dose-related increase in hypertrophied chondrocytes, subchondral bony plate formation, and inhibition of vascular invasion of the growth plate. In addition, decreased ovarian and uterine weights and an absence of corpora lutea were observed in females receiving 10 and 50 mg/kg/dose in the 13-wk study. Both the physeal and ovarian changes were reversible with cessation of treatment. No other treatment-related effects were observed following rhuMAbVEGF administration at doses up to 50 mg/kg. These findings indicate that VEGF is required for longitudinal bone growth and corpora lutea formation and that rhuMAbVEGF can reversibly inhibit physiologic neovascularization at these sites.
Effect of professional flossing with NaF or SnF2gel on approximal caries in 13-16-year-old schoolchildren (1999)

The aim of this study was to evaluate the effect of professional flossing with NaF and SnF2 gels on caries development on approximal tooth surfaces. Two-hundred-and-eighty 13-year-old schoolchildren were divided into 3 groups: (1) NaF (n = 97), (2) SnF2 (n = 85), and (3) placebo gel group (n = 98). The investigation was carried out double-blind. The children were treated 4 times a year for 3 years with 1% NaF gel, 1% SnF2 gel, or placebo gel. The treatment was carried out by dental nurses and the time required per visit was approximately 10 min. After 3 years, the mean approximal caries increment, including initial caries lesions, was 2.8 in the NaF, 2.4 in the SnF2, and 4.0 in the placebo gel group (P< 0.05 for SnF2 vs placebo); a reduction compared to the placebo of 30% and 39% in the NaF and SnF2 groups, respectively. Thus, professional flossing with NaF or SnF2 gel carried out 4 times a year may be considered as an interesting caries-preventing method for large-scale application in schoolchildren.
Biological Markers Predictive of Invasive Recurrence in DCIS (2008)

DCIS is a heterogeneous group of non-invasive cancers of the breast characterized by various degrees of differentiation and unpredictable propensity for transformation into invasive carcinoma. We examined the expression and prognostic value of 9 biological markers with a potential role in tumor progression in 133 patients with pure DCIS treated with breast conserving surgery alone, between 1982–2000. Histology was reviewed and immunohistochemical staining was performed. Pearson correlation coefficient was used to determine the associations between markers and histopathological features. Univariate and multivariate analysis examined associations between time to recurrence and clinico-pathologic features and biological markers. Median age at diagnosis was 55 years (25–85). With a median follow up of 8.91 years, 41/133 patients recurred (21 as invasive recurrence). In this cohort 13.5% had low, 43% intermediate and 42% high nuclear grade. Comedo necrosis was found in 65% of cases. Expression of ER (62.4%), PR (55.6%), HER2/neu (31.6%), MIB1 (39.8%), p53 (22.6%), p21 (39.8%), Cyclin D1 (95.5%) calgranulin (20.5%), psoriasin (12%), was found in DCIS. HER2/neu was overexpressed in 45% that recurred as DCIS and 42.9% that recurred as invasive cancer, and only in 26.1% in cases that never recurred. On univariate analysis, HER2/neu overexpression was the only marker associated with an increased risk for any recurrence (p = 0.044). The hazard ratio for recurrence for HER2/neu positive DCIS was 1.927 (confidence interval 1.016–3.653) compared to HER2 negative DCIS. On multivariate analysis, HER2/neu overexpression remained the only independent variable significantly associated with any recurrence (p = 0.014) and with invasive recurrence (p = 0.044). This data suggest that HER2/neu testing may become an important parameter in the management of DCIS and the treatment of cases with positive HER2/neu status could be modified accordingly, similar to the current approach for HER2/neu positive invasive disease.