gebhart/patrepeval huggingface dataset:
Design of a 4-Bit Microprocessor (1991)

A four bit microprocessor’s layout was drawn on an Apollo workstation using MOSIS two lambda design rules. The layout’s operation was verified by breadboarding with 74’00 HCMOS logic parts during Spring Quarter 1990 by Theodore D’Antonoli. Based on his findings, the layout was revised and several design changes were added. At the same time, a software simulation program (uPROSIM) for the processor was written in FORTRAN on the RIT VMS Computer System.
Digital Rights Management (2001)

It was only three years ago that I was told that publishing valuable digital content on the Internet would not take off for 10 years. Today it is happening all around us with MP3 music files being swapped by our children and market research reports openly passed between business colleagues. The problem is that the intellectual property owners lose control of distribution through publishing content on the Internet – in its raw essence, an unregulated global arena – and then, more often than not, do not get paid for use of a large percentage of their content, This is perhaps the greatest reason why publishers have been unwilling to place valuable content online. Historically low-value content has taken up the vast majority of what we have been able to access online with companies hoping to recoup costs through advertising revenue. The reason is simple; conventional Internet technologies do not have any facilities for enforcing copyright, but the problem is that advertising revenues are dwindling so publishers need to find other ways of generating revenue. We can now look back with a sense of irony at straplines from major technology companies saying “Information at your finger tips”, “Information where and how you need it” as this is exactly what they are now trying to prevent so that they can keep an element of control.
Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes (2012)

The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wild-type influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.
Pulmonary Hypertension (2009)

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Tracking non-rigid objects in complex scenes (2002)

The authors describe a model-based method for tracking nonrigid objects moving in a complex scene. The method operates by extracting two-dimensional models of an object from a sequence of images. The basic idea underlying the technique is to decompose the image of a solid object moving in space into two components: a two-dimensional motion and a two-dimensional shape change. The motion component is factored out and the shape change is represented explicitly by a sequence of two-dimensional models, one corresponding to each image frame. The major assumption underlying the method is that the two-dimensional shape of an object will change slowly from one frame to the next. There is no assumption, however, that the two-dimensional image motion between successive frames will be small.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Formulation approaches to pediatric oral drug delivery: benefits and limitations of current platforms (2015)

Despite the incentives provided by recent regulatory modifications and the efforts of formulation scientists, there is still a need for implementation of pharmaceutical technologies that enable the manufacture of licensed age-appropriate formulations. Harmonization of endeavors from regulators, industry and academia by sharing learning associated with data obtained from pediatric investigation plans, product development pathways and scientific projects would be the way forward to speed up bench-to-market age appropriate formulation development. A collaborative approach will benefit not only pediatrics, but other patient populations such as geriatrics would also benefit from an accelerated patient-centric approach to drug delivery.
HIGH-DOSE PORCINE HEMATOPOIETIC CELL TRANSPLANTATION COMBINED WITH CD40 LIGAND BLOCKADE IN BABOONS PREVENTS AN INDUCED ANTI-PIG HUMORAL RESPONSE (2000)

We believe these studies are the first to consistently demonstrate prevention of a secondary humoral response after cell or organ transplantation in a pig-to-primate model. The development of sensitization to the murine elements of the anti-CD40L monoclonal antibodies suggests that nonresponsiveness to cell membrane-bound antigen (e.g., alphaGal) is a specific phenomenon and not a general manifestation of immunological unresponsiveness. T cell costimulatory blockade may facilitate induction of mixed hematopoietic chimerism and, consequently, of tolerance to pig organs and tissues.
La barrière hémato-encéphalique (2011)

The blood-brain barrier (BBB), which isolates the brain from the whole body, restricts exchanges between the brain and the peripheral compartments. Several studies highlight the importance of this barrier in neurodegenerative diseases such as Alzheimer's disease (AD). This pathology is characterized by an abnormal accumulation and aggregation of Aβ peptides which contribute to the neurodegenerative processes and the BBB seems to play a key role for the brain Aβ peptides metabolism. This review focuses on recent data demonstrating the important role of the BBB in AD, suggesting that this barrier is a possible new therapeutic target in this disease.
Enhanced effect of liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection in beige mice (1988)

We examined the therapeutic effects of free and liposome-encapsulated amikacin on Mycobacterium avium-M. intracellulare complex infection by using the beige-mouse model of the disease. In the first series of studies, intravenous administration of four weekly doses of 5 mg of amikacin per kg encapsulated in large (approximately 0.4-micron diameter), unilamellar liposomes arrested the growth of M. avium-M. intracellulare complex organisms in the liver, as measured by CFU counts. M. avium-M. intracellulare complex levels in untreated animals and in those treated with the same dose of free amikacin increased by several orders of magnitude over 8 weeks. Liposome-encapsulated amikacin was also effective against M. avium-M. intracellulare complex organisms in the spleen and kidneys, reducing the CFU counts by about 1,000-fold compared with those of both untreated controls and free-drug-treated mice. In the lungs, a slight reduction in CFU was observed in the liposome-encapsulated-amikacin-treated group, but only at the 8-week point. Neither free nor liposome-encapsulated amikacin reduced the colony counts in the lymph nodes compared with those of control animals. Reductions in CFU in all organs greater than those caused by the liposome preparation could be achieved by intramuscular administration of free amikacin, but only at a 10-fold-higher dose given 6 days a week for 8 weeks. In the second series of studies, we investigated the effects of (i) doubling the dose of liposome-encapsulated amikacin and (ii) increasing the size of the liposomes and prolonging the treatment to five injections. Administration of 10 mg of amikacin per kg in liposomes 2 to 3 micrometer in diameter was more effective in the liver than 5 or 10 mg of amikacin per kg in liposomes 0.2 micrometer in diameter. A slight reduction in the CFU levels in the lungs was observed with the higher dose, irrespective of liposome size. Our results indicate that liposome-based delivery of amikacin enhances its anti-M. intracellulare complex activity, particularly in the liver, spleen, and kidney, and may therefore improve the therapy of this disease.
Competitive Bidding: Department of Defense and Private Sector Practices (1988)

Government is ever vigilant to promote competition in the federal acquisition process (especially in the Department of Defense [DOD]), hoping to reduce the prices it pays for supplies and services, to enhance the industrial base, to provide opportunities for every responsible offeror to compete, and to some extent to align its buying procedures with the private sector. In its quest for fairness, equity, and competition, the government has created a myriad of rules, regulations, and procedures. The underlying assumption seems to be that private industry is more competitive and efficient, and that government can duplicate this behavior by legislative process. However, a comparison of DOD and commercial competitive buying reveals a significant difference in their behavior due to different goals, philosophies, accountability, and procedural guidance.
A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐catenin (1999)

The Axin-dependent phosphorylation of beta-catenin catalysed by glycogen synthase kinase-3 (GSK3) is inhibited during embryogenesis. This protects beta-catenin against ubiquitin-dependent proteolysis, leading to its accumulation in the nucleus, where it controls the expression of genes important for development. Frequently rearranged in advanced T-cell lymphomas 1 (FRAT1) is a mammalian homologue of a GSK3-binding protein (GBP), which appears to play a key role in the correct establishment of the dorsal-ventral axis in Xenopus laevis. Here, we demonstrate that FRATtide (a peptide corresponding to residues 188-226 of FRAT1) binds to GSK3 and prevents GSK3 from interacting with Axin. FRATtide also blocks the GSK3-catalysed phosphorylation of Axin and beta-catenin, suggesting a potential mechanism by which GBP could trigger axis formation. In contrast, FRATtide does not suppress GSK3 activity towards other substrates, such as glycogen synthase and eIF2B, whose phosphorylation is independent of Axin but dependent on a 'priming' phosphorylation. This may explain how the essential cellular functions of GSK3 can continue, despite the suppression of beta-catenin phosphorylation.
Electrical Properties of the Epoxy Nano-composites according to Additive (2009)

The use of a filler material in epoxy composite materials is an essential condition for reducing the unit cost of production and reinforcing mechanical strength. However, the dielectric strength of insulators decreases rapidly due to interactions between the epoxy resin and filler particles. In contrast to existing composite materials, nano-composite materials have superior dielectric strength, mechanical strength, and enduring chemical properties due to an increase in the bond strength of the polymer and nano material, It is reported that nano-fillers provide new characteristics different from the properties of the polymer material. This study is to improve the insulation capability of epoxy resins used in the insulation of a power transformer apparatus and many electronic devices mold. To accomplish this, the additional amount of nano-<TEX>$SiO_2$</TEX> to epoxy resin was changed and the epoxy/<TEX>$SiO_2$</TEX> nano composite materials were made, and the fundamental electrical properties were investigated using a physical properties and an analysis breakdown test. Using allowable breakdown probability, the optimum breakdown strength for designing an electrical apparatus was determined. The results found that the electrical characteristics of the nano-<TEX>$SiO_2$</TEX> content specimens were superior to the virgin specimens. The 0.4 wt% specimens showed the highest electrical properties among the specimens examined with an allowable breakdown probability of 20 %, which indicates stable breakdown strength in insulating machinery design.
Selection of Bone Grafts for Revision Total Hip Arthroplasty (2000)

The selection of bone grafts to reconstruct deficient bone for revision hip replacement requires an understanding of specific bone graft functions and the critical steps of the biologic incorporation of the graft into the host. Bone grafts provide functions of osteogenesis, either graft derived or by osteoinduction, osteoconduction, or both, and mechanical support. Autologous cancellous bone provides excellent osteogenesis and osteoconduction without structural support. Nonvascularized cortical autografts provide mechanical support and are somewhat osteogenic. Allogeneic cancellous bone is osteoconductive and minimally osteoinductive, whereas cortical allografts provide structural support, if not freeze-dried, and are somewhat osteoconductive. Allogeneic demineralization bone matrix is highly osteoinductive. The selection of the appropriate bone graft depends on the classification of the bone deficiency. Cavitary (contained) defects can be reconstructed with cancellous morselized autograft, frozen or freeze-dried allograft, or allogeneic demineralized bone matrix. Segmental defects require bulk corticocancellous and/or cortical autografts or allografts. The ultimate incorporation of the bone graft depends on the interaction of the graft and the host's mechanical and biologic environment, and host-bone graft contact and stability. Optimum bone graft selection will enhance the clinical outcomes in revision total hip arthroplasty.
Iterative modulo scheduling (1994)

Modulo scheduling is a framework within which a wide variety of algorithms and heuristics may be defined for software pipelining innermost loops. This paper presents a practical algorithm, iterative modulo scheduling, that is capable of dealing with realistic machine models. This paper also characterizes the algorithm in terms of the quality of the generated schedules as well the computational expense incurred.
Programming DNA Tube Circumferences (2008)

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.
Smectic Phase in a Colloidal Suspension of Semiflexible Virus Particles (1997)

Aqueous suspensions of micron-length, charged, semiflexible fd virus particles are studied experimentally in order to explore properties of the cholesteric-smectic phase transition in a system approximating flexible, hard rods. Through comparison of this system with (1) computer simulations of hard, rigid rods, (2) experiments on tobacco mosaic virus, a rigid, charged virus, and on pf1, a flexible, charged virus, and (3) with recent theories of the nematic-smectic transition in flexible rods, we argue that flexibility raises the volume fraction at the phase transition, lowers the ratio of the smectic periodicity to the contour length, and drives the transition first order.
Sudden Cardiac Death Prediction and Prevention (2010)

D espite the significant decline in coronary artery disease (CAD) mortality in the second half of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 US lives annually. 4] However, even in the presence of advanced first responder systems for resuscitation of out-of-hospital cardiac arrest, the overall survival rate in a recent North American analysis was 4.6%. 8 SCD can manifest as ventricular tachycardia (VT), ventricular fibrillation (VF), pulseless electric activity (PEA), or asystole. In a significant proportion of patients, SCD can present without warning or a recognized triggering mechanism. The mean age of those affected is in the mid 60s, and at least 40% of patients will suffer SCD before the age of 65.
Apoptosis of rat's ovarian follicle cells induced by triptolide in vivo. (2010)

This present study aimed to investigate ovarian follicular apoptosis and development in rats administrated with different dosages of triptolide (TR).Thirty healthy female Sprague Dawley rats were randomly divided into 3 groups (n = 10), including placebo group (water and 0.06% Dimethyl Sulfoxide); high dose(HD) group (120 μg/kg.d TR) and low dose (LD) group (60 μg/kg.d TR). Vaginal smear was daily performed to estimate each rat’s estrous cycle, while body weight was measured every 4 days to evaluate rat’s growth pattern and adjust the dosage. Left ovary of each rat was resected and then serial section was performed for follicular classification and counts. Apoptosis was detected with TUNEL assay and then positively-stained follicles were classified and calculated. Compared with the placebo and LD groups, the average estrous cycle was significantly longer in the HD group (p < 0.01). The secondary follicle in both HD and LD groups was significantly more than the control groups (p < 0.05), while there were no significant changes of primordial follicle and antral follicle among three groups. Furthermore, higher proportion of apoptotic follicle in the stage of secondary follicle was found in both HD and LD groups. TR presented dose-dependent inhibition on estrous cycle and apoptosis induction in secondary follicle, which might account for female gonad depression activities.

	 

	Key words: Triptolide; ovarian follicle; apoptosis; rat.
Direct tunneling gate leakage current in transistors with ultrathin silicon nitride gate dielectric (2000)

We present a study on the characterization and modeling of direct tunneling gate leakage current in both N- and P-type MOSFETs with ultrathin silicon nitride (Si/sub 3/N/sub 4/) gate dielectric formed by the jet-vapor deposition (JVD) technique. The tunneling mechanisms in the N- and PMOSFETs were clarified. The electron and hole tunneling masses and barrier potentials for the different tunneling mechanisms mere extracted from measured data using a new semi-empirical model. This model was used to project the scaling limits of the JVD Si/sub 3/N/sub 4/ gate dielectric based on the supply voltages for the various technology nodes and the maximum tolerable direct tunneling gate current for high-performance and low-power applications.
CD7 Is a Differentiation Marker That Identifies Multiple CD8 T Cell Effector Subsets (2003)

The adaptive immune response of human CD8 T cells to invading pathogens involves the differentiation of naive cells into memory and effector cells. However, the lineage relationship between memory and effector cells and the differentiation of CD8 T cells into distinct subsets of effector cell subpopulations are subjects of considerable debate. CD7 identifies three populations of CD8 T cells: CD7 high (CD7(high)), low (CD7(low)), and negative (CD7(neg)) that translate into subsets with distinct functional properties. The CD7(high) subset contains naive and memory cells and the CD7(low) and CD7(neg) subsets contain effector cells. The effector cells can functionally be divided into cytokine-secreting effector CD8 T cells and lytic effector CD8 T cells. These data provide a model of human CD8 T cell differentiation in which specialized distinct subpopulations can be identified by expression of CD7.
Frequent Aberrant Methylation of p16INK4a in Primary Rat Lung Tumors (1997)

The p16INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous deletion or methylation of the 5' CpG island in cell lines derived from human non-small-cell lung cancers. However, the frequency of dysfunction in primary tumors appears to be significantly lower than that in cell lines. This discordance could result from the occurrence or selection of p16 dysfunction during cell culture. Alternatively, techniques commonly used to examine tumors for genetic and epigenetic alterations may not be sensitive enough to detect all dysfunctions within the heterogeneous cell population present in primary tumors. If p16 inactivation plays a central role in development of non-small-cell lung cancer, then the frequency of gene inactivation in primary tumors should parallel that observed in cell lines. The present investigation addressed this issue in primary rat lung tumors and corresponding derived cell lines. A further goal was to determine whether the aberrant p16 gene methylation seen in human tumors is a conserved event in this animal model. The rat p16 gene was cloned and sequenced, and the predicted amino acid sequence of its product found to be 62% homologous to the amino acid sequence of the human analog. Homozygous deletion accounted for loss of p16 expression in 8 of 20 cell lines, while methylation of the CpG island extending throughout exon 1 was observed in 9 of 20 cell lines. 2-Deoxy-5-azacytidine treatment of cell lines with aberrant methylation restored gene expression. The methylated phenotype seen in cell lines showed an absolute correlation with detection of methylation in primary tumors. Aberrant methylation was also detected in four of eight primary tumors in which the derived cell line contained a deletion in p16. These results substantiate the primary tumor as the origin for dysfunction of the p16 gene and implicate CpG island methylation as the major mechanism for inactivating this gene in the rat lung tumors examined. Furthermore, rat lung cancer appears to be an excellent model in which to investigate the mechanisms of de novo gene methylation and the role of p16 dysfunction in the progression of neoplasia.
Accommodation and presbyopia in the human eye. Changes in the anterior segment and crystalline lens with focus. (1997)

Because changes along the sagittal axis of the anterior segment with accommodation are independent of age, any explanation of presbyopia that relies on simple changes in the rates of lens thickening and anterior chamber shallowing with age does not hold. In light of other age-related changes in the anterior segment and lens (e.g., increased sharpness of lens curvature, increased lens sagittal thickness, decreased anterior chamber depth), it appears that compensatory mechanisms to preserve far vision with age also preserve the rate of change per diopter of sagittal spacings.
A Single Cis-acting Element in a Short Promoter Segment of the Gene Encoding the Interphotoreceptor Retinoid-binding Protein Confers Tissue-specific Expression (1995)

Interphotoreceptor retinoid-binding protein (IRBP) is the major protein component of the interphotoreceptor matrix. IRBP has a highly restricted tissue-specific expression in retinal photoreceptor cells and in a subgroup of pinealocytes. With the purpose of understanding how transcriptional regulation contributes to the expression of human IRBP, we have studied a short promoter fragment (from -123 to +18, relative to the transcription start site). We demonstrate, by analysis of the expression of the lacZ reporter gene fused to this short promoter fragment in transgenic mice, that it is sufficient to confer tissue-specific expression in retinal photoreceptors and in pinealocytes. DNA/protein binding assays, performed to identify binding sites for tissue-specific trans-acting factors, have shown that an element between -45 and -58 binds a factor present only in nuclear extracts of retinoblastoma-derived cell lines, which express IRBP. An element further upstream, between -86 and -106, binds apparently ubiquitous factors. Site-directed mutagenesis was performed to disrupt a GATTAA motif included in the -45 to -58 binding site and a second inverted GATTAA motif present shortly upstream. In transgenic mice bearing the mutated version of the promoter fragment, the expression of the reporter gene was completely abolished, thus suggesting that this element is essential for tissue-specific expression. A GATTAA motif appears in the 5'-flanking regions of several photoreceptor-specific genes, suggesting that this could be the recognition site for a photoreceptor-specific factor.