gebhart/patrepeval huggingface dataset:
Status of the Nevis Synchrocyclotron Modification (1972)

The Columbia Univ. Nevis Synchrocyclotron Modification should give ∼ 20 μA (time average) of 560 to 570 MeV protons in an external beam of ≥ 50% duty factor at a 300 Hz rep. rate. A 3‐fold symmetry azimuthally varying field is used. The final 360° and sector iron shimming touchup is now completed. Orbit studies show proton orbit stability for acceleration and extraction. About 80% extraction efficiency is indicated. Dee and ground skin installation is nearly complete. Rf operation, internal beam and extraction studies are expected to be followed by operation for experiments by late 1972 or early 1973. No fundamental problems with the systems have developed. External Be targets are used for π and μ beam production, with three secondary charged particle beam lines. Pulsed neutron t.o.f. spectroscopy is also permitted.
Construction of Full-Length-Enriched cDNA Libraries: The Oligo-Capping Method (2003)

The full-length cDNA, which contains the entire sequence of the mRNA, is the ultimate goal for cDNA cloning. Unfortunately, cDNA libraries constructed by many types of conventional methods have a high content of nonfull-length cDNA clones. One of the reasons for this is that reverse transcriptase (RT) tends to stop during the first strand synthesis and falls off, leaving nonfull-length cDNA. Thus, nonfull-length cDNA is an inevitable result of the use of RT for the synthesis of cDNA.
[Role of Foxp3/Treg and RORγt/Th17 cell imbalance in rat model of chronic obstructive pulmonary disease]. (2014)

There is a relationship among decreased pulmonary function, inflammation and imbalance of Foxp3/Treg and RORγt/Th17 in COPD.
Perovskite-type oxide membranes for the oxidative coupling of methane (1997)

A series of ion-conducting perovskites of the form [La1-xAx] [Co0.2Fe0.8] O3-δ (x = 0.4, 0.6 for A = Sr; × = 0.8 for A = Ba) were investigated for their use as a catalytic membrane for the oxidative coupling of methane (OCM). A-site cations consisting of La0.4Sr0.6 and La0.2Ba0.8 produce materials with the highest oxygen fluxes and result in C2+ selectivities of 50% at 1,098 K, which are significantly higher than those achieved with a powdered catalyst in a packed-bed reactor configuration. Selectivities in these materials appear to be limited by high oxygen ion recombination rates that compete for oxygen with the desired coupling reaction(s). The results also indicate that oxygen fluxes are not limited by diffusion, but by surface exchange rates at the oxygen-lean side of the membrane. The study on stability of these materials showed that all three perovskites could be reduced in a pure methane or ethane stream at 1,023 K, but they were totally stable under reaction conditions where oxygen is present.
Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients (2008)

Acute myeloid leukemia (AML) is considered an oncologic emergency. Delaying induction chemotherapy until molecular testing results return, may benefit some patients but harm others. We examined the effect of time from AML diagnosis to treatment (TDT) on complete remission (CR) and overall survival (OS), using patient characteristics available at diagnosis. Regression models were applied to older (> or = 60 years) and younger (< 60 years) adults, controlling for age, baseline white blood cell count, secondary AML (sAML), and performance status. Median patient age was 60 years (range, 17-87 years), TDT 4 days (range, 1-78 days), and 45% had sAML. Cytogenetic risk distribution was: favorable, 8%; intermediate, 66%; unfavorable, 26%. CR rate was 67% and median OS was 68 weeks in patients younger than 60 years; 55% and 33 weeks in older patients, respectively. In univariate and multivariate analyses, longer TDT was associated with worse CR and OS in younger (univariate: P < .001 in both; multivariate: P < .001 and P = .001, respectively), but not older patients (univariate: P = .45, P = .19; multivariate: P = .63, P = .30, respectively). Results did not change with inclusion of cytogenetic data or in risk group subsets. AML therapy should be initiated immediately in younger patients. Delaying treatment does not seem harmful in older patients, allowing individualized approaches.
Conceptual system design of a 5 MWh/100 MW superconducting flywheel energy storage plant for power utility applications (1997)

The authors have designed a 5 MWh/100 MW superconducting flywheel energy storage plant. The plant consists of 10 flywheel modules rated at 0.5 MWh/10 MW each. Module weight is 30 t, size is /spl phi/ 3.5 m/spl times/6.5 m high. A synchronous type motor-generator is used for power input/output. Each flywheel system consists of four disk modules made from a carbon fibre composite material, rated at 125 kWh and weighing 3 t. Passive superconducting bearings, integrated into the disk modules, are used for frictionless levitation. The operating speed will be in the 2250...4500 RPM range. Maximum rim velocity is 600 m/s with a maximum tensile stress of 810 MPa. Details of the system layout are discussed, addressing thermal design and subsystems such as power conditioning system and cooling facilities. A preliminary cost analysis has been worked out. In the Western European UCPTE (Union for the Coordination of Production and Transport of Electricity) high power system, the plant could be used to provide spinning reserve for about 30 s while conventional thermal generating units ramp up to meet the increased load during peak power periods. Other applications in the electric utility field include power conditioning and stabilization in portions of a high-voltage power system.
The Role of Complement in the Aetiopathogenesis of Systemic Lupus Erythematosus (1991)

The role of classical pathway complement components in systemic lupus erythematosus (SLE) is reviewed. Their importance in maintaining immune complexes (IC) in soluble form and in enhancing clearance of IC through binding to red cell CR1 is such that deficiency, complete or partial, of these components or some of their controlling enzymes can lead to IC mediated disease like SLE. C2 and C4 are encoded within the class III region of the major histocompatibility complex (MHC). There are certain well described associations between class II MHC genes and the occurrence of SLE and the relative importance of the two sets of gene products and their potential interactions are discussed. Complement C4 plays a role in drug induced lupus as many of the lupus associated drugs bind to C4 and interfere with its protective functions. Classical genetic studies provide clear evidence that non MHC genes are important in the aetiopathogenesis of SLE. Non MHC encoded complement deficiencies and functional deficits may well represent some of these other genetic factors and is clearly a fertile area for future research.
Dream Lens (2018)

This paper presents Dream Lens, an interactive visual analysis tool for exploring and visualizing large-scale generative design datasets. Unlike traditional computer aided design, where users create a single model, with generative design, users specify high-level goals and constraints, and the system automatically generates hundreds or thousands of candidates all meeting the design criteria. Once a large collection of design variations is created, the designer is left with the task of finding the design, or set of designs, which best meets their requirements. This is a complicated task which could require analyzing the structural characteristics and visual aesthetics of the designs. Two studies are conducted which demonstrate the usability and usefulness of the Dream Lens system, and a generatively designed dataset of 16,800 designs for a sample design problem is described and publicly released to encourage advancement in this area.
A Refined Basket of Goods Approach for Comparing Construction Costs between Countries (2012)

Most comparisons of construction industry performance requirethat construction costs be converted to a common base. Existingmechanisms for such conversions produce unreliable results.A proposed method for producing industry-specifi c conversionfactors was tested using a single building type. A basket ofmaterials and labour was identifi ed and weighted to refl ect the costshare of each item in a completed project. Prices for the basketwere gathered in three cities and simple construction specifi cconversion indices were calculated based on the constructionpurchasing power of each currency. The construction purchasingpower parities (CPPPs) showed marked differences from otheravailable conversion mechanisms such as exchange rates andgeneral purchasing power parities (PPPs) that have been used inprevious international comparison studies. While the study waslimited in scope, and is only the fi rst stage of a longer process, thesubstantial differences in comparative costs based on purchasingpower illustrate the problems inherent in international costcomparisons. For example, comparing Singapore and Sydney,Singapore costs appear to be only 40% of those in Sydney (basedon exchange rates) about two-thirds the cost of Sydney (usinggeneral PPPs) or almost the same (using the preliminary CPPPs).These results illustrate the problems of converting costs fromlocal currencies to a single base currency and suggest that furtherdevelopment is needed to improve the reliability of outcomes.
The Type III Secretion System of Xanthomonas fuscans subsp. fuscans Is Involved in the Phyllosphere Colonization Process and in Transmission to Seeds of Susceptible Beans (2008)

Understanding the survival, multiplication, and transmission to seeds of plant pathogenic bacteria is central to study their pathogenesis. We hypothesized that the type III secretion system (T3SS), encoded by hrp genes, could have a role in host colonization by plant pathogenic bacteria. The seed-borne pathogen Xanthomonas fuscans subsp. fuscans causes common bacterial blight of bean (Phaseolus vulgaris). Directed mutagenesis in strain CFBP4834-R of X. fuscans subsp. fuscans and bacterial population density monitoring on bean leaves showed that strains with mutations in the hrp regulatory genes, hrpG and hrpX, were impaired in their phyllospheric growth, as in the null interaction with Escherichia coli C600 and bean. In the compatible interaction, CFBP4834-R reached high phyllospheric population densities and was transmitted to seeds at high frequencies with high densities. Strains with mutations in structural hrp genes maintained the same constant epiphytic population densities (1 x 10(5) CFU g(-1) of fresh weight) as in the incompatible interaction with Xanthomonas campestris pv. campestris ATCC 33913 and the bean. Low frequencies of transmission to seeds and low bacterial concentrations were recorded for CFBP4834-R hrp mutants and for ATCC 33913, whereas E. coli C600 was not transmitted. Moreover, unlike the wild-type strain, strains with mutations in hrp genes were not transmitted to seeds by vascular pathway. Transmission to seeds by floral structures remained possible for both. This study revealed the involvement of the X. fuscans subsp. fuscans T3SS in phyllospheric multiplication and systemic colonization of bean, leading to transmission to seeds. Our findings suggest a major contribution of hrp regulatory genes in host colonization processes.
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. (1994)

The beta gamma subunits (G beta gamma) of heterotrimeric G proteins modulate the activity of several signal-transducing effector molecules including G protein-coupled receptor kinases. G beta gamma binds to the carboxyl terminus of the beta-adrenergic receptor kinase (beta ARK) and regulates its activity. To investigate the effect of such a G beta gamma-binding domain on heterologous G beta gamma interactions, various receptors that can stimulate phospholipase C and/or type II adenylate cyclase were coexpressed in COS-7 cells with the carboxyl terminus of beta ARK1. Phosphoinositol hydrolysis in response to activation of receptors that stimulate phospholipase C via Gi beta gamma (alpha 2-adrenergic and M2-muscarinic cholinergic receptors) was markedly inhibited by the coexpressed beta ARK1 polypeptide, whereas that mediated by Gq alpha subunits (alpha 1-adrenergic and M1-muscarinic cholinergic receptors) was unaffected. Increased cellular cAMP levels due to stimulation of receptors and coexpressed adenylate cyclase II displayed marked inhibition in the presence of the beta ARK1 polypeptide. Moreover, inhibition of adenylate cyclase produced by alpha 2-adrenergic receptor stimulation (a Gi alpha-mediated process) was unaffected, indicating that the beta ARK1 polypeptide provides a useful tool for distinguishing between G alpha and G beta gamma pathways.
Standardization of Automated Analyses of Oculomotor Fixation and Saccadic Behaviors (2010)

In an effort towards standardization, this paper evaluates the performance of five eye movement classification algorithms in terms of their assessment of oculomotor fixation and saccadic behavior. The results indicate that performance of these five commonly used algorithms vary dramatically even in the case of a simple stimulus evoked task using a single, common threshold value. The important contributions of this paper are: 1) evaluation and comparison of performance of five algorithms to classify specific oculomotor behavior 2) introduction and comparison of new standardized scores to provide more reliable classification performance 3) logic for a reasonable threshold value selection for any eye movement classification algorithm based on the standardized scores and 4) logic for establishing a criterion-based baseline for performance comparison between any eye movement classification algorithms. Proposed techniques enable efficient and objective clinical applications providing means to assure meaningful automated eye movement classification.
Perspective on BiCMOS VLSIs (1988)

A high-performance BiCMOS technology (Hi-BiCMOS) and its applications to VLSIs are described. By combining bipolar and CMOS devices in unit circuits of VLSIs, Hi-BiCMOS provides both speed performance competitive with bipolar LSIs and integration density close to that of CMOS LSIs. Hi-BiCMOS technology has been successfully used for static RAMs, dynamic RAMs, and gate arrays. The effectiveness of its applications to some types of processors has also been examined by evaluating test chips.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ESH Position Paper (2012)

Experts from the European Society of Hypertension prepared this position paper in order to summarize current evidence, unmet needs and practical recommendations on the application of percutaneous transluminal ablation of renal nerves [renal denervation (RDN)] as a novel therapeutic strategy for the treatment of resistant hypertension. The sympathetic nervous activation to the kidney and the sensory afferent signals to the central nervous system represent the targets of RND. Clinical studies have documented that catheter-based RDN decreases both efferent sympathetic and afferent sensory nerve traffic leading to clinically meaningful systolic and diastolic blood pressure (BP) reductions in patients with resistant hypertension. This position statement intends to facilitate a better understanding of the effectiveness, safety, limitations and issues still to be addressed with RDN.
MICA: a holistic approach to fast in-memory key-value storage (2014)

MICA is a scalable in-memory key-value store that handles 65.6 to 76.9 million key-value operations per second using a single general-purpose multi-core system. MICA is over 4-13.5x faster than current state-of-the-art systems, while providing consistently high throughput over a variety of mixed read and write workloads.MICA takes a holistic approach that encompasses all aspects of request handling, including parallel data access, network request handling, and data structure design, but makes unconventional choices in each of the three domains. First, MICA optimizes for multi-core architectures by enabling parallel access to partitioned data. Second, for efficient parallel data access, MICA maps client requests directly to specific CPU cores at the server NIC level by using client-supplied information and adopts a light-weight networking stack that bypasses the kernel. Finally, MICA's new data structures--circular logs, lossy concurrent hash indexes, and bulk chaining--handle both read-and write-intensive workloads at low overhead.
All-fiber bidirectional passively mode-locked ring laser (2007)

We report the design and operation of a novel all-fiber bidirectional passively mode-locked ring laser. An erbium-doped fiber was chosen as the active element in a ring cavity arrangement. A short segment of a fiber taper embedded in carbon nanotubes/polymer composite, acting as a saturable absorber, was used to enable bidirectional mode locking. The laser generates two stable femtosecond pulse trains in opposite directions. A beat note of about 2 MHz, having a bandwidth of less than 2 kHz, is measured when the pulses propagating in opposite directions are (temporally) overlapped at a photodetector. We believe this device will find important applications in precision rotation sensing.
Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants (2009)

Identifying the specific genetic characteristics of successfully transmitted variants may prove central to the development of effective vaccine and microbicide interventions. Although human immunodeficiency virus transmission is associated with a population bottleneck, the extent to which different factors influence the diversity of transmitted viruses is unclear. We estimate here the number of transmitted variants in 69 heterosexual men and women with primary subtype C infections. From 1,505 env sequences obtained using a single genome amplification approach we show that 78% of infections involved single variant transmission and 22% involved multiple variant transmissions (median of 3). We found evidence for mutations selected for cytotoxic-T-lymphocyte or antibody escape and a high prevalence of recombination in individuals infected with multiple variants representing another potential escape pathway in these individuals. In a combined analysis of 171 subtype B and C transmission events, we found that infection with more than one variant does not follow a Poisson distribution, indicating that transmission of individual virions cannot be seen as independent events, each occurring with low probability. While most transmissions resulted from a single infectious unit, multiple variant transmissions represent a significant fraction of transmission events, suggesting that there may be important mechanistic differences between these groups that are not yet understood.
Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness. (1993)

To elucidate the biological significance of the p53 gene expression in human hepatocellular carcinoma (HCC), the p53 protein was studied in 184 resected unifocal primary HCCs, including 102 small (< or = 5 cm) and 82 large HCCs (> 5 cm), using immunocytochemistry. The p53 mRNA expression was analyzed in 69 cases using Northern hybridization. The p53 protein, which was detected in 58 HCCs (31.5%), was overexpressed more frequently in HCC with elevated serum alpha-fetoprotein level (37.9 versus 25%, P < 0.04), in large HCC (39.0 versus 25.5%, P < 0.03), and in invasive HCC (35.1 versus 13.3%, P < 0.01). The overexpression of p53 protein closely correlated with p53 mRNA overexpression (75 versus 44.4%, P < 0.003), and p53 gene mutation (76.9 versus 19.2%, P < 1 x 10(-9)). HCCs with p53 protein expression (group A) and those negative for both p53 protein and mRNA expression (group B) had an unfavorable outcome, while HCC with no p53 protein but with p53 mRNA overexpression (group C) had the best outcome; the 4-year survival was 26.1, 26.3, and 62.5%, respectively. The p53 gene mutation was significantly higher in group A HCC (76.9%) than in groups B (27.3%) and C (23.5%), P < 0.0001. The results suggest that the p53 protein and mRNA expression patterns in HCC correlate with p53 gene mutation and tumor behavior and may serve as a molecular prognostic factor.
Allergen-Specific Human T Cell Clones Produce lnterleukin-5 upon Stimulation with the Th1 Cytokine lnterleukin-2 (1995)

CD4+ T cell clones specific for Der fII (a major allergen of the house dust mite) were established from peripheral blood mononuclear cells of atopic patients. All of the T cell clones were classified as having the Th0 phenotype, since they produced both interleukin (IL)-2 and IL-4 upon stimulation. Some of the clones produced IL-5 upon antigenic stimulation. Human recombinant IL-2 induced these T cell clones to express IL-5 mRNA and produce IL-5 protein in a dose-dependent manner. IL-2 did not induce IL-4 production, indicating a discrete signal requirement for IL-4 versus IL-5 production by T cells. Moreover, IL-5 production induced by immobilized anti-CD3 monoclonal antibody was completely suppressed by the addition of anti-IL-2 monoclonal antibody, suggesting that IL-5 production, designated as a Th2-type immune response, is dependent on IL-2, a Thl cytokine. IL-2 produced at the site of allergic inflammation may contribute to IL-5 production by T cells in vivo.
Two New Triterpenes from the Husks ofXanthoceras sorbifolia (2005)

Two new triterpenes, 22-angeloyl-21-epoxyangeloylbarringtogenol C (1) and 21,22-diangeloyl-24-hydroxy-R(1)-barrigenol (2), and the known 21,22-diangeloyl-R(1)-barrigenol (3) were isolated from the husks of Xanthoceras sorbifolia Bunge. Their structures were elucidated based on detailed NMR analysis. Compounds 1 and 2 inhibited significantly the growth of cancer cell lines (A375-S2, HeLa) with IC(50) values ranging from 2.9 to 76.3 micromol/L.
Procalcitonin-Guided Antibiotic Use vs a Standard Approach for Acute Respiratory Tract Infections in Primary Care (2008)

As an adjunct to guidelines, procalcitonin-guided therapy markedly reduces antibiotic use for acute respiratory tract infections in primary care without compromising patient outcome. In practice, this could be achieved with 1 to 2 procalcitonin measurements in patients for whom the physician intends to prescribe antibiotics.
Mishaps during transport from the intensive care unit (1990)

We undertook a prospective study of 125 intrahospital patient transports from the ICU in an attempt to identify any factors that could influence the occurrence of mishaps. One third of the transports sustained at least one mishap. Therapeutic intervention scoring system class IV transports had the highest rate of mishaps (35%). We found no relationship of occurrence of mishaps to severity of illness (Acute Physiology and Chronic Health Evaluation, APACHE II), number of lines, monitoring and support modalities, and time out of the ICU. Transports for elective procedures had more mishaps (60%) than occurred for emergencies (40%). Most mishaps occurred either during the procedure, on transports to CT scan, or while waiting at the destination. The numbers and types of escorts as defined by our ICU policy and physician attendance on transport did not clearly reduce mishap risk. Morbidity and mortality were not affected by mishaps. Although certain trends did emerge, no clearly defined predictive factor could be identified. Further study into transport mishaps is warranted.