gebhart/patrepeval huggingface dataset:
Oracle backup & recovery handbook : 7.3 edition (1997)

Written by back up expert Rama Velpuri, Oracle Backup & Recovery Handbook, 7.3 Edition will give you an overview of the Oracle RDBMS architecture, including a discussion of the basic procedures needed to understand backup and recovery procedures; various backup procedures specific to certain operating system environments; the difference between logical and physical backups; concepts of recovery, involving crucial recovery structures and detailed recovery procedures; and a new case study featuring the Standby Database capabilities of Oracle7 Release 7.3. Packed with real-life case studies, Oracle Backup & Recovery Handbook, 7.3 Edition is required reading for anyone responsible for strategic data management. Case studies based on Oracle's exclusive customer histories have descriptions of system failures and solutions giving the best and fastest way to recover the database, with other recovery options listed. You'll also find actual backup scripts (code) that you can use, and discussions of Oracle7 Release 7.3's new functionality.
Effect of vasopressin on portal venous pressure. (1983)

Portal venous pressure measurements were made through percutaneous transhepatic portal vein catheterization in 29 cirrhotics with portal hypertension and in seven controls before and after intravenous vasopressin infusion in a dosage of 0.24 IU/min. In cirrhotic patients the decrease in portal pressure was 8.5% being not statistically significant, while in the control group the decrease was 12% (p less than 0.05). Five of six cirrhotic patients (85%) whose acute bleedings were previously controlled with i.v. vasopressin infusion had reversed portal vein flow. On the other hand, only three of ten (30%) patients whose bleeding failed to be controlled with vasopressin had reversed flow in the portal vein. The difference between these two groups is statistically significant (p less than 0.05) and may suggest that variceal bleeding is most effectively controlled with i.v. vasopressin in cirrhotics with well developed collaterals and reversed portal vein flow.
Overexpression of Hedgehog Signaling Molecules and Its Involvement in the Proliferation of Endometrial Carcinoma Cells (2007)

The abnormal activation of this pathway is involved in the proliferation of endometrial carcinoma cells possibly in an auto-/paracrine fashion, suggesting the possibility of the hedgehog pathway being a novel candidate for molecular targeting.
Complex hormonal regulation of rat casein gene expression. (1982)

Cloned cDNAs for three rat casein mRNAs (CY, p, and y) and a fourth abundant mammary gland mRNA, designated pX32 mRNA, have been used to isolate pure single-stranded cDNA probes from total cDNA synthesized using poly(A+) mRNA.These probes have been employed in a sensitive cDNA titration hybridization assay to measure the levels of these mRNAs in total RNA extracts both during normal mammary gland development and in organ culture in response to the hormones, prolactin and hydrocortisone.The results of the solution hybridization experiments were compared to those of a dot hybridization assay in which doublestranded cloned cDNA probes were hybridized to RNA immobilized on diazobenzyloxymethyl-ceIlulose filters.A significant level of each of the mRNAs was found in virgin glands.During the first 6 days after conception, the relative proportions of these mRNAs changed considerably.The levels of all four mRNAs then increased coordinately during the remainder of pregnancy and lactation, In organ culture, both prolactin and hydrocortisone were found to be essential for maximum induction of all four mRNAs.By 24 h after prolactin ' J. M. Rosen and J. Rodgers, unpublished observations.
Enhanced transfection efficiency of a systemically delivered tumor-targeting immunolipoplex by inclusion of a pH-sensitive histidylated oligolysine peptide (2004)

Successful cancer gene therapy depends on the development of non-toxic, efficient, tumor cell- specific systemic gene delivery systems. Our laboratory has developed a systemically administered, ligand-liposome complex that can effectively and preferentially deliver its therapeutic payload to both primary and metastatic tumors. To further improve the transfection efficiency of this targeting complex, a synthetic pH-sensitive histidylated oligolysine K[K(H)KKK]5-K(H)KKC (HoKC), designed to aid in endosomal escape and condensation of DNA, was included in the complex. The presence of HoKC increased the in vitro transfection efficiency over that of the original complex. Moreover, no increase in cytotoxicity was observed due to the presence of the HoKC peptide. In a DU145 human prostate cancer xenograft tumor model in athymic nude mice, inclusion of the HoKC peptide did not interfere with the tumor targeting specificity of the i.v. administered ligand/liposome/DNA complex. Most importantly, the level of transgene expression was significantly elevated in the tumors, but not in the normal tissue in those animals receiving the complex incorporating HoKC. The in vivo enhancement of transfection efficiency by this modified gene delivery vehicle could lead to a reduction in the number of administrations required for antitumor efficacy.
Pyrazine composition of wood smoke as influenced by wood source and smoke generation variables (1985)

Abstract A series of 8 pyrazines (pyrazine, 3‐ethyl‐2‐methoxy‐, 2‐ethoxy‐3‐ethyl‐, 3,6‐dimethyl‐2‐propyl‐, 2‐butyl‐3,5‐dimethyl‐, 2‐butyl‐3,6‐dimethyl‐, 2‐acetyl‐3‐methyl‐, 2‐acetyl‐3,5‐dimethylpyrazine) were identified in the smoke generated from 17 different wood sources (white and red oak, walnut, chestnut, apple, redwood, red alder, cherry, aspen, birch, hard maple, eastern cedar, hickory, Lodgepole pine wood and bark, Douglas‐Fir heartwood and sapwood). Hickory produced the largest amount (41.03 mg 100 g wood) of total pyrazines while redwood had the least (10.33 mg). Total and individual pyrazine levels did not appear to correlate with wood nitrogen content nor with the levels of cellulose, hemicellulose or lignin. Smoke generation variables relative to pyrazine formation were evaluated with hickory smoke. Increasing the moisture content from 4 per cent to 20 or 30 per cent resulted in decreased total pyrazine levels. The absence of air decreased total pyrazine concentration while increasing smoke generation temperature from 290 to 450°C increased the total amount of pyrazines formed. Collection of hickory smoke volatiles in an alkaline solution resulted in lower total pyrazine levels than condensate trapped in water.
Antibody Engineering (2000)

Antibodies are unique in their high affinity and specificity for a binding partner, a quality that has made them one of the most useful molecules for biotechnology and biomedical applications. The field of antibody engineering has changed rapidly in the past 10 years, fueled by novel technologies for the in vitro isolation of antibodies from combinatorial libraries and their functional expression in bacteria. This review presents an overview of the methods available for the de novo generation of human antibodies, for engineering antibodies with increased antigen affinity, and for the production of antibody fragments. Select applications of recombinant antibodies are also presented.
Physical Unclonable Function Exploiting Sneak Paths in Resistive Cross-point Array (2016)

The physical unclonable function (PUF) is a promising innovative hardware security primitive that leverages the inherent randomness in the physical systems to produce unique responses upon the inquiry of challenges, thus the PUF could serve as a fingerprint for device authentication. In this paper, we propose a novel PUF implementation exploiting the sneak paths in the resistive cross-point (X-point) array, as a hardware security primitive. The entanglement of the sneak paths in the X-point array greatly enhances the entropy of the physical system, thereby increasing the space of challenge-response pairs to make a strong PUF. The X-point PUF characteristics, such as uniqueness and reliability, are experimentally evaluated on the fabricated 12 × 12 cross-point arrays based on the Pt/HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> /TiN structure. The measurement results show that the average inter-Hamming distance of the response bits is around 46.2% across 28 different arrays, showing sufficient uniqueness. The measurement results also demonstrate that 0% intra-Hamming distance (or 100% reliability) of the response bits can be maintained more than 7.2 h at 100 °C (or equivalently ten years at 40 °C). This paper demonstrates the feasibility of using X-point PUF as a lightweight and reliable PUF for device authentication.
Fully Printed Halide Perovskite Light-Emitting Diodes with Silver Nanowire Electrodes (2015)

Printed organometal halide perovskite light-emitting diodes (LEDs) are reported that have indium tin oxide (ITO) or carbon nanotubes (CNTs) as the transparent anode, a printed composite film consisting of methylammonium lead tribromide (Br-Pero) and poly(ethylene oxide) (PEO) as the emissive layer, and printed silver nanowires as the cathode. The fabrication can be carried out in ambient air without humidity control. The devices on ITO/glass have a low turn-on voltage of 2.6 V, a maximum luminance intensity of 21014 cd m(-2), and a maximum external quantum efficiency (EQE) of 1.1%, surpassing previous reported perovskite LEDs. The devices on CNTs/polymer were able to be strained to 5 mm radius of curvature without affecting device properties.
Double infection with a Resistant and a Multidrug-Resistant Strain of Mycobacterium tuberculosis (2000)

An immunocompetent patient was dually infected with a resistant and a multidrug-resistant strain of Mycobacterium tuberculosis (TB). The multidrug-resistant strain, which belongs to the W- strain/Beijing family, was first isolated after 3 months of therapy. Inappropriate treatment led to further drug resistance and unsuccessful therapy. Thus, additional infections with resistant M. tuberculosis strains should be considered when tuberculosis therapy fails.
Broadband single-polarization photonic crystal fiber (2005)

We demonstrate a single-mode photonic crystal fiber that supports only one polarization state in a 220-nm-broad spectral region centered at 727 nm. The fiber has a mode-field diameter of 15.5 microm and background losses of < 15 dB/km in the single-polarization region. To our knowledge, these are the broadest bandwidth and the largest mode size yet reported for a single-polarization fiber.
Multicopy Crystallographic Refinement of a Relaxed Glutamine Synthetase from Mycobacterium tuberculosis Highlights Flexible Loops in the Enzymatic Mechanism and Its Regulation (2002)

The crystal structure of glutamine synthetase (GS) from Mycobacterium tuberculosis determined at 2.4 Å resolution reveals citrate and AMP bound in the active site. The structure was refined with strict 24-fold noncrystallographic symmetry (NCS) constraints and has an R-factor of 22.7% and an R-free of 25.5%. Multicopy refinement using 10 atomic models and strict 24-fold NCS constraints further reduced the R-factor to 20.4% and the R-free to 23.2%. The multicopy model demonstrates the range of atomic displacements of catalytic and regulatory loops in glutamine synthesis, simulating loop motions. A comparison with loop positions in substrate complexes of GS from Salmonella typhimurium shows that the Asp50 and Glu327 loops close over the active site during catalysis. These loop closures are preceded by a conformational change of the Glu209 β-strand upon metal ion or ATP binding that converts the enzyme from a relaxed to a taut state. We propose a model of the GS regulatory mechanism based on the loop motions in which adenylylation of the Tyr397 loop reverses the effect of metal ion binding, and regulates intermediate formation by preventing closure of the Glu327 loop.
Harpin and hydrogen peroxide both initiate programmed cell death but have differential effects on defence gene expression in Arabidopsis suspension cultures (1998)

Programmed cell death is increasingly viewed as a key component of the hypersensitive disease resistance response of plants. The generation of reactive oxygen species (ROS) such as H2O2 triggers a cell death programme in Arabidopsis suspension cultures following challenge with the bacterial elicitor harpin. Both harpin and exogenous H2O2 initiate a cell death pathway that requires gene expression, and also act as signalling molecules to induce the expression of plant defence genes encoding enzymes such as phenylalanine ammonia-lyase (PAL), glutathione S-transferase (GST) and anthranilate synthase (ASA1), an enzyme of phytoalexin biosynthesis in Arabidopsis. H2O2 induces the expression of PAL1 and GST but not that of ASA1. Harpin initiates two signalling pathways, one leading to increased ROS generation and expression of PAL1 and GST mRNA, and another leading to increased GST and ASA1 expression, independent of H2O2.
The toughest transistor yet [GaN transistors] (2002)

GaN transistors withstand extreme heat and are capable of handling frequencies and power levels well beyond those possible with silicon, gallium arsenide, silicon carbide, or essentially any other semiconductor yet fabricated. Frequency and power-handling capabilities of this caliber could make all the difference in amplifiers, modulators, and other key components of the advanced communications networks. GaN transistors could double or triple the efficiency of base-station amplifiers, so that a given area could be covered by fewer base stations or, more likely, be flooded with more data at much higher rates. These same characteristics of speed, high-power handling, and heat resistance would also suit the transistors for many other uses.
Organization of Rigid Wedge−Flexible Coil Block Copolymers into Liquid Crystalline Assembly (2005)

The synthesis and characterization of wedge−coil block molecules with a poly(ethylene oxide) coil of 77 (1a), 91 (1b), 114 (1c), and 182 (1d) ethylene oxide units are described. The self-assembling behavior of these block polymers in the melt state was investigated by optical polarized microscopy, differential scanning calorimetry (DSC), X-ray scattering measurements, and transmission electron microscopy (TEM). Block polymers self-organize from 1-D lamellar to 2-D hexagonal columnar liquid crystalline phases as the length of the PEO chain increases. This result demonstrates that supramolecular nanostructures can be controlled in a rigid wedge−flexible coil block copolymer system through introduction of a long flexible coil.
Spoken and written news story segmentation using lexical chains (2003)

In this paper we describe a novel approach to lexical chain based segmentation of broadcast news stories. Our segmentation system SeLeCT is evaluated with respect to two other lexical cohesion based segmenters TextTiling and C99. Using the Pk and WindowDiff evaluation metrics we show that SeLeCT outperforms both systems on spoken news transcripts (CNN) while the C99 algorithm performs best on the written newswire collection (Reuters). We also examine the differences between spoken and written news styles and how these differences can affect segmentation accuracy.
Place and response learning in human virtual navigation: Behavioral measures and gender differences. (2007)

Two experiments examined the use of place and response strategies by humans navigating virtual multiple T mazes. In Experiment 1, probe trials revealed that participants commonly used place and response strategies, and place strategies were more frequent early in training, whereas response strategies were more frequent late in training. Compared with women, men learned the correct path through the maze more quickly and developed a more stable route through the maze. In Experiment 2, participants were trained to locate 2 targets. One target required participants to use either a place or response strategy, whereas the other target could be found using either strategy. Accuracy improved faster for place training compared with response training, and women outperformed men in both groups. Probe trials testing transfer of the imposed strategy to the other target found faster transfer for place training than for response training and that women demonstrated faster transfer than men. Accuracy on probe trials was correlated with poor route stability in the place-trained group and with good route stability in the response-trained group, indicating that navigation strategy use may be related to measures of improvement in performance on normal trials.
Cross-linking of MHC class I molecules on human NK cells inhibits NK cell function, segregates MHC I from the NK cell synapse, and induces intracellular phosphotyrosines (2004)

Engagement of major histocompatibility complex (MHC) class I molecules on immune cells, where they are usually highly expressed, induces signal transduction events of unclear significance. We show here that antibody-mediated cross-linking of MHC-I molecules on human natural killer (NK) cells inhibits their cytotoxic activity against tumor target cells. Inhibition by anti-MHC class I monoclonal antibody exhibits molecular specificity and is an isotype and Fc-independent process. Physical hindrance of specific molecular recognition, induction of apoptosis, or reciprocal NK cell killing, which could be induced by cross-linking of MHC I molecules, has also been ruled out as putative mechanisms of inhibition. Confocal microscopy analysis revealed that MHC class I molecules on the surface of NK cells colocalize constitutively with GM1, a marker of lipid rafts. Cross-linking of MHC class I resulted in the asymmetric redistribution of GM1-enriched raft domains, which are concentrated to the immunological synapse, and MHC I molecules, which segregate to the opposite pole. Also, the cross-linking of MHC I on NK cells induced intracellular tyrosine phosphorylations. These results suggest that MHC I molecules on NK cells could transmit inhibitory signals upon engagement with putative ligands expressed on the surface of those cells that need to be protected from natural cytotoxicity.
The Plasticity of Regulatory T Cell Function (2011)

Regulatory T cells (T(regs)) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. Whereas T(regs) possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any interrelationship or cross-regulatory mechanisms exist to orchestrate and control their utilization is unknown. In this study, we assessed the functional capacity of T(regs) lacking the ability to secrete both IL-10 and IL-35, which individually are required for maximal T(reg) activity. Surprisingly, IL-10/IL-35 double-deficient T(regs) were fully functional in vitro and in vivo. Loss of IL-10 and IL-35 was compensated for by a concurrent increase in cathepsin E (Ctse) expression, enhanced TRAIL (Tnfsf10) expression, and soluble TRAIL release, rendering IL-10/IL-35 double-deficient T(regs) functionally dependent on TRAIL in vitro and in vivo. Lastly, whereas C57BL/6 T(regs) are normally IL-10/IL-35 dependent, BALB/c T(regs), which express high levels of cathepsin E and enhanced TRAIL expression, are partially TRAIL dependent by default. These data reveal that cross-regulatory pathways exist that control the utilization of suppressive mechanisms, thereby providing T(reg) functional plasticity.
The Genetic Bases for the Variation in the Lipo-oligosaccharide of the Mucosal Pathogen, Campylobacter jejuni (2002)

We have compared the lipo-oligosaccharide (LOS) biosynthesis loci from 11 Campylobacter jejuni strains expressing a total of 8 different ganglioside mimics in their LOS outer cores. Based on the organization of the genes, the 11 corresponding loci could be classified into three classes, with one of them being clearly an intermediate evolutionary step between the other two. Comparative genomics and expression of specific glycosyltransferases combined with in vitro activity assays allowed us to identify at least five distinct mechanisms that allow C. jejuni to vary the structure of the LOS outer core as follows: 1) different gene complements; 2) phase variation because of homopolymeric tracts; 3) gene inactivation by the deletion or insertion of a single base (without phase variation); 4) single mutation leading to the inactivation of a glycosyltransferase; and 5) single or multiple mutations leading to "allelic" glycosyltransferases with different acceptor specificities. The differences in the LOS outer core structures expressed by the 11 C. jejuni strains examined can be explained by one or more of the five mechanisms described in this work.
Casein Kinase 1 Delta Phosphorylates Tau and Disrupts Its Binding to Microtubules (2004)

Tau hyperphosphorylation precedes neuritic lesion formation in Alzheimer's disease, suggesting it participates in the tau fibrillization reaction pathway. Candidate tau protein kinases include members of the casein kinase 1 (CK1) family of phosphotransferases, which are highly overexpressed in Alzheimer's disease brain and colocalize with neuritic and granulovacuolar lesions. Here we characterized the contribution of one CK1 isoform, Ckidelta, to the phosphorylation of tau at residues Ser202/Thr205 and Ser396/Ser404 in human embryonic kidney 293 cells using immunodetection and fluorescence microscopy. Treatment of cells with membrane permeable CK1 inhibitor 3-[(2,3,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261) lowered occupancy of Ser396/Ser404 phosphorylation sites by >70% at saturation, suggesting that endogenous CK1 was the major source of basal phosphorylation activity at these sites. Overexpression of Ckidelta increased CK1 enzyme activity and further raised tau phosphorylation at residues Ser202/Thr205 and Ser396/Ser404 in situ. Inhibitor IC261 reversed tau hyperphosphorylation induced by Ckidelta overexpression. Co-immunoprecipitation assays showed direct association of tau and Ckidelta in situ, consistent with tau being a Ckidelta substrate. Ckidelta overexpression also produced a decrease in the fraction of bulk tau bound to detergent-insoluble microtubules. These results suggest that Ckidelta phosphorylates tau at sites that modulate tau/microtubule binding, and that the expression pattern of Ckidelta in Alzheimer's disease is consistent with it playing an important role in tau aggregation.