gebhart/patrepeval huggingface dataset:
Relationship of Human Papillomavirus Type to Grade of Cervical Intraepithelial Neoplasia (1992)

OBJECTIVE--To determine the relationship of human papillomavirus (HPV) type to grade of cervical intraepithelial neoplasia (CIN) in a large series of cases. DESIGN--A survey of HPV types in CIN lesions detected using a new, highly accurate method for typing HPV that is based on restriction fragment length polymorphism analysis of amplimers produced during polymerase chain amplification of the conserved L1 region of HPV using consensus primers. SETTING--Private gynecologists' offices and inner-city colposcopy clinics. PATIENTS--A convenience sample of 276 HPV DNA-positive cervical biopsy specimens or samples from patients undergoing colposcopy for abnormal Papanicolaou smears. INTERVENTION--None. MAIN OUTCOME MEASURE(S)--Human papillomavirus type(s). RESULTS--Cervical intraepithelial neoplasia 1 lesions were relatively heterogeneous with regard to associated HPV types. Nineteen percent of CIN 1 lesions were associated with HPV types 6 or 11; 29% contained HPV types 16, 18, or 33; and 19% were associated with "novel types" of HPV. It was also found that 22% of CIN 1 lesions were associated with more than one HPV type. In contrast to CIN 1, both CIN 2 and CIN 3 were relatively homogeneous with regard to associated HPV types. Eighty-eight percent of CIN 2 and 3 lesions contained HPV types 16, 18, or 33. Unlike CIN 1 lesions, which often contained multiple types of HPV, only 7% of CIN 2 and 3 lesions were associated with multiple HPV types. CONCLUSIONS--Cervical intraepithelial neoplasia should be classified into two separate categories--low-grade and high-grade CIN. Since only 29% of low-grade lesions are associated with HPV types 16, 18, or 33, HPV type could potentially play a role in determining the most appropriate clinical management of patients with low-grade CIN. However, prospective follow-up studies of lesional behavior based on HPV type are required before clinical recommendations can be made.
The Causes and Consequences of Chromosomal Aberrations (1992)

Chromosome Analyses at the Molecular Level: Molecular Cytogenetics: Applications of Fluorescence Hybridization to Chromosomal Aberrations and Cancer Genetics (Y. Xing and J.B. Lawrence). Gene Mapping by Genetic Linkage and Somatic Cell Hybrid Analysis (O. Wesley McBride). The Occurrence of Chromosomal Aberrations in Normal, Premalignant, and Malignant Cells: Chromosome Aberrations in Simpler Eukaryotes (A. Aguilera and H. Klein). Myc-Associated Chromosomal Translocations and Rearrangements in Plasmacytogenesis in Mice (F. Wiener and M. Potter). Acquired Chromosomal Aberrations in Normal Individuals (A. Aurias). Chromosome Changes in Leukemia and Cancer and Their Molecular Limning (A.A. Sandberg). Clonal T-Cell Proliferation in Ataxia Telangiectasia (M.-H.Stern). Hybrid Antigen Receptor Genes: A Model of Translocation in Lymphoid Cells and a Marker for the Risk of Developing a Lymphoid Malignancy (S. Lipkowitz and I. R. Kirsch). Constitutional Chromosome Aneuploidy and Cancer (N. Sacchi). Deletions of 5q and Myeloid Leukemias (C.A. Westbrook and M.M. Le Beau). The Mechanism(s) of Formation of Chromosomal Aberrations: The Role of Site-Directed Recombinases in Physiologic and Pathologic Chromosomal Rearrangements (M.R. Lieber). The Mechanisms of Formation of Chromosomal Aberrations: Role of Eukaryotic DNA Topoisomerases (Y. Pommier and R. Bertrand). Specific Instructive Examples: Chromosomal Translocations Involving the c-myc Oncogene in Lymphoid Neoplasia (R.Dalla-Favera). Human B-Cell Neoplasms with the t(11 14) (q13 q32) and T(14 18) (q32 q21) Chromosomal Translocations (Y. Tsujimoto). Themes and Variations among the Mature Lymphoid Leukemias (M.J.S. Dyer and D. Catovsky). Ph-Positive Leukemia (N. Heisterkamp, J.-W. Voncken, H. van Schaick, and J. Groffen). The Causes and Consequences of Chromosomal Aberrations: Acute Myeloid Leukemia (M.R. Baer and C.D. Bloomfield). Structural and Functional Consequences of Chromosomal Translocation in Human T-Cell Tumors (T.H. Rabbitts and T. Boehm). Lymphoid Malignancies That Disrupt Homeotic and HLH Genes (P.D. Aplan and I.R. Kirsch). The Misadventures of RB1 (B.L. Gallie). Cytogenetic Characterization of Colorectal and Breast Carcinomas (B. Dutrillaux, M. Gerbault-Seureau, C. Saint-Ruf, V. Bardot, M. Prieur, and M. Muleris). Perspectives on the Development of Molecular Cytogenetics: Cytogenetics of Acquired Chromosomal Abnormalities: From Chromosome to Gene (R. Berger). The Road to the Ig/myc Translocation (G. Klein). From Chromosomes to Oncogenes: A Personal Perspective (P.C. Nowell). Index.
A robust threshold elliptic curve digital signature providing a new verifiable secret sharing scheme (2006)

Robust threshold digital signature schemes are group signature schemes aiming to depart from the classical one person signer schemes. The term 'robust' means that such schemes can tolerate errors attempted by malicious adversary and the term 'threshold' means that given a total of n players, no coalition of players with cardinality less than or equal the threshold value can perform the signature while any coalition of players exceeding the threshold value can perform the signature correctly. The contributions in this paper are two fold. First, we propose a new verifiable secret sharing scheme (VSS) other than Feldman's (1987) and Pedersen's (1992) schemes suitable to protect elliptic curve secret keys. The proposed scheme utilizes a strong one way function provided by the elliptic curve cryptography based on a different type of group mathematics. Next, we employ the elliptic curve VSS to propose a robust threshold elliptic curve digital signature scheme that can withstand an n/2 eavesdropping, n/3 halting and an n/4 malicious adversary. The scheme is able to tolerate n/3 malicious adversary with the cost of higher complexity
The Proline-Catalyzed Direct Asymmetric Three-Component Mannich Reaction:  Scope, Optimization, and Application to the Highly Enantioselective Synthesis of 1,2-Amino Alcohols (2002)

We have developed proline-catalyzed direct asymmetric three-component Mannich reactions of ketones, aldehydes, and amines. Several of the studied reactions provide beta-amino carbonyl compounds (Mannich products) in excellent enantio-, diastereo-, regio-, and chemoselectivities. The scope of each of the three components and the influence of the catalyst structure on the reaction are described. Reaction conditions have been optimized, and the mechanism and source of asymmetric induction are discussed. We further present application of our reaction to the highly enantioselective synthesis of 1,2-amino alcohols.
cDNA and deduced amino acid sequence of murine Cu - Zn superoxide dismutase (1988)

Cu-Zn superoxide dismutase (EC 1.15.1.1) is a eukaryotic cytoplasmic enzyme involved in the antioxidant defense against the toxic effects of superoxide anion-induced cellular damage (1). We have isolated cDNA clones from a murine SWR/J liver cDNA library (2) using the human cDNA clone pS61-10 as a heterologous probe (3). The nucleotide and deduced amino acid sequence of one of these clones containing the entire coding region is shown below. The murine enzyme is coded for by 459 nt after ATG followed by a single stop codon. The deduced amino acid sequence exhibits 83.7% identity to the human enzyme (3) and 96.7% identity to the rat enzyme (4). The 3-non-coding end following TAA is 66 nt in length and contains an uncommon polyadenylation signal, ATTAAA, 16 nt upstream of the poly(A) tail. This clone hybridizes to a single band of RNA isolated from mouse liver with a molecular size between 0.5-0.6 kb.
Mobility-Aware, Correlation-Based Node Grouping and Selection for Cooperative Spectrum Sensing (2014)

Cooperative spectrum sensing has been proposed as a solution to increase the sensing function accuracy in cognitive radio networks, but the research has, so far, mainly focused on static scenarios, all but neglecting the impact of mobility on spectrum sensing. In this work a novel cooperative spectrum sensing scheme for mobile cognitive networks, based on a correlation-based, mobility-aware node selection algorithm is proposed. Correlation among sensing decisions is used to divide nodes into groups, and mobility is taken into account in the group leaders selection by means of a node selection metric that considers both sensing performance and mobility. Performance of the proposed algorithm is evaluated by computer simulations taking into account mobility and a detailed modeling of temporal and spatial correlation of fading and shadowing components in the channel path loss, going way beyond the performance evaluation carried out in previous works on correlation-based cooperative sensing schemes. Simulation results highlight that the proposed metric leads to a significant increase of the update period required to maintain acceptable sensing performance, and correspondingly to a strong reduction in the overhead caused by the grouping and node selection procedure.
Contribution of Vascular Endothelial Growth Factor in the Neovascularization Process during the Pathogenesis of Herpetic Stromal Keratitis (2001)

This report analyzes the role of vascular endothelial growth factor (VEGF)-induced angiogenesis in the immunoinflammatory lesion stromal keratitis induced by ocular infection with herpes simplex virus (HSV). Our results show that infection with replication-competent, but not mutant, viruses results in the expression of VEGF mRNA and protein in the cornea. This a rapid event, with VEGF mRNA detectable by 12 h postinfection (p.i.) and proteins detectable by 24 h p.i. VEGF production occurred both in the virus-infected corneal epithelium and in the underlying stroma, in which viral antigens were undetectable. In the stroma, VEGF was produced by inflammatory cells; these initially were predominantly polymorphonuclear leukocytes (PMN), but at later time points both PMN and macrophage-like cells were VEGF producers. In the epithelium, the major site of VEGF-expressing cells in early infection, the infected cells themselves were usually negative for VEGF. Similarly, in vitro infection studies indicated that the cells which produced VEGF were not those which expressed virus. Attesting to the possible role of VEGF-induced angiogenesis in the pathogenesis of herpetic stromal keratitis were experiments showing that VEGF inhibition with mFlt(1-3)-immunoglobulin G diminished angiogenesis and the severity of lesions after HSV infection. These observations are the first to evaluate VEGF-induced angiogenesis in the pathogenesis of stromal keratitis. Our results indicate that the control of angiogenesis represents a useful adjunct to therapy of herpetic ocular disease, an important cause of human blindness.
Viral induction and targeted inhibition of galectin-1 in EBV+ posttransplant lymphoproliferative disorders (2011)

Posttransplant lymphoproliferative disorders (PTLDs) are potentially fatal, EBV-driven B-cell malignancies that develop in immunocompromised solid organ or hematopoietic stem cell recipients. In PTLD, the expression of EBV proteins, including latent membrane protein 1 (LMP1) and LMP2A, viral immune evasion strategies, and impaired host immune surveillance foster the proliferation of EBV-transformed B cells. Current PTLD treatment strategies include reduction of immunosuppression, which increases the risk of graft rejection, anti-CD20 treatment, combination chemotherapy, and administration of EBV-specific cytotoxic T cells. In the present study, we report that EBV-transformed lymphoblastoid B-cell lines (LCLs) and primary PTLDs overexpress galectin-1 (Gal1), a carbohydrate-binding lectin that induces tolerogenic dendritic cells and triggers the selective apoptosis of CD4(+) Th1 and Th17 cells and cytotoxic T cells. In transcriptional reporter assays, LMP2A and LMP1 each increased Gal1-driven luciferase expression, and the combination of LMP2A and LMP1 was additive. In addition, small interfering RNA (siRNA)-mediated depletion of LMP2A decreased Gal1 protein abundance in EBV-transformed LCLs. Gal1 expression in LCLs was dependent on both activating protein 1 (AP-1) and PI3K. A newly developed neutralizing Gal1 mAb selectively inhibited Gal1-mediated apoptosis of EBV-specific CD8(+) T cells. Given the tolerogenic and immunosuppressive function of Gal1, antibody-mediated Gal1 neutralization may represent a novel immunotherapeutic strategy for PTLD and other Gal1-expressing tumors.
Passive Hip Range of Motion Predicts Femoral Torsion and Acetabular Version (2016)

This study confirmed that passive hip range of motion significantly predicts combined femoral torsion and central acetabular version. Accurate clinical assessment of the COTAV index may inform surgical decision-making in hip preservation surgery.
Plasma Lipoprotein Induction and Suppression of the Generation of Cellular Procoagulant Activity in Vitro (1981)

Isolated human plasma very low density, intermediate density, and high density lipo-proteins at physiologic concentrations have been demonstrated in the preceding report to induce significant increases in the procoagulant activity of human peripheral blood mononuclear cells in vitro, whereas low density lipoprotein did not. The monocyte was identified in this study by cellular fractionation and by direct cytologic assays as the source of this inducible activity, thus identifying the procoagulant activity as a monokine. The generation of these lipoprotein-induced procoagulant monokines was entirely dependent upon the presence of lymphocytes. Isolated lymphocytes that had been exposed to the stimulatory lipoproteins could induce monocytes to produce the procoagulant activity, whereas neither the culture medium from lipoprotein-stimulated lymphocytes, homogenates of lymphocytes, nor other cells such as platelets could substitute for this requirement. The interaction of the stimulatory lipoproteins with lymphocytes was rapid, reaching completion within 30 min, and was equally effective at either 4 degrees or 37 degrees C. Low density lipoprotein did not stimulate lymphocytes to induce monocyte procoagulant activity, but did actively suppress the production of the procoagulant monokines induced by each of the stimulatory lipoproteins, as well as bacterial lipopolysaccharide. The monocyte was identified as the cell sensitive to low density lipoprotein suppression, and no suppression of lymphocyte triggering was observed. These observations on the interaction of plasma lipoproteins with lymphocytes and monocytes in vitro introduce two new regulatory events by which plasma lipoproteins influence the function of cells, and define a regulatory network by which certain lipoprotein classes trigger lymphocytes, which can in turn induce monocytes to express procoagulant activity. Only this latter phase is subject to lipoprotein suppression by physiologic concentrations of low density lipoprotein.
PROCESSES OF DOLOMITIZATION IMPORTANT FACTORS INFLUENCING PORE GEOMETRY AND RESERVOIR QUALITY IN MISSISSIPPIAN INNER SHELF CARBONATES OF SOUTHEASTERN SASKATCHEWAN (1984)

The origin of the dolomites that form hydrocarbon reservoirs in inner shelf lime mudstones and wackestone of the Mississippian Midale and Ratcliffe Beds of southeastern Saskatchewan is not clearly understood. However, studies of the geometry of pore systems using capillary pressure mercury injection analyses supplemented by scanning electron microscopy aid elucidation of the processes that created the dolomitized reservoir rocks. There is fairly good evidence that entry pressures obtained from capillary pressure mercury injection analyses are markedly influenced by the calcareousness of the carbonate res.ervoir rock; the greater the proportion of dolomite present, the lower the entry pressure. In addition, it has been shown that the best dolomite reservoir is one in which 7590 to 9090 of the rock has been dolomitized (inhibition boundary stage of crystal growth). When the degree of dolomitization increases beyond 9090 the dolomite cyrstals enter a compromise boundary stage of growth, resulting in a reduction of pore volume and permeability, Attainment of the inhibition boundary stage is not sufficient to produce a good reservoir; it must be accompanied by dissolution of the remnant host rock, creating porosities ranging from 25Vo to 3890 and permeabilities on the order tens of millidarcies. An additional factor that creates good reservoir rock in the inhibition boundary stage ofcrystal growth is the uniform size of crystals and pore throats, easily recognized on capillary pressure mercury saturation plots. The most likely dolomitizing mechanism by which both inhibition boundary stage and remnant host rock dissolution could be facilitated is the mixing zone process. Fresh meteoric waters capable of dissolving the remnant host rock would enter the dolomitized rock proceeding the passage of the mixing zone through it. In contrast, reflux dolomitization would be more likely to cause either a compromise boundary stage of dolomitization or produce a calcareous dolomite.
Insulin-like growth factor 1 and hair growth (1999)

Insulin-like growth factor 1 (IGF-1) has been identified as an important growth factor in many biological systems.[1] It shares considerable structural homology with insulin and exerts insulin-like effects on food intake and glucose metabolism. Recently it has been suggested to play a role in regulating cellular proliferation and migration during the development of hair follicles. [2,3] To exert its biological effects, the IGF-1 is required to activate cells by binding to specific cell-surface receptors. The type I IGF receptor (IGF-1R) is the only IGF receptor to have IGF-mediated signaling functions.[1] In circulation, this growth factor mediates endocrine action of growth hormone (GH) on somatic growth and is bound to specific binding proteins (BPs). The latter control IGF transport, efflux from vascular compartments and association with cell surface receptors.[4] In tissues, IGF-1 is produced by mesenchymal type cells and acts in a paracrine and autocrine fashion by binding to the IGF-1R. This binding activates the receptor tyrosine kinase (RTK) that triggers the downstream responses and finally stimulates cell division.[5] IGF-1 may therefore be able to stimulate the proliferation of hair follicle cells through cellular signaling pathways of its receptors. Local infusion of IGF-1 into sheep has been reported to be capable of stimulating protein synthesis in the skin.[6] It may also increase the production of wool keratin. Recently, transgenic mice overexpressing IGF-1 in the skin have been shown to have earlier hair follicle development than controls.[7] In addition, this growth factor plays an important role in many cell types as a survival factor to prevent cell death.[8] This anti-apoptotic function of IGF-1 may be important to the development of follicle cells as follicles undergo a growth cycle where the regressive, catagen phase is apoptosis driven. In this review, the effects of IGF-1 on follicle cell proliferation and differentiation are discussed. In particular, the paracrine versus endocrine action of IGF-1 on hair growth and the targeting of expression of the growth factor to the follicles of transgenic animals will be emphasized. The anti-apoptotic role of IGF-1 in hair follicles is also reviewed. Prospects for future studies on hair and fiber growth by IGF-1 are discussed.
[Chronic inflammatory bowel disease--current status]. (1992)

Chronic inflammatory bowel disease (IBD) encompasses the disease entities, ulcerative colitis (UC) and Crohn's disease (CD). An aetiologic agent has not yet been defined and the diagnosis is based, therefore, on the sum of clinical, paraclinical, radiologic, endoscopic and histopathologic features. In recent years pathogenetic studies have focused on immune mechanisms, transmissible infectious agents, the potential role of the normal intestinal flora, dietary factors, enzymatic alterations and genetic features, in addition to vascular, neuromotor, allergic and psychologic factors. The prevalence of IBD is increased in first-degree relatives of patients and there is a high rate of disease concordance among monozygotic twins. Thus abnormal genes may encode for one or several immunoregulatory factors, while bacterial wall products seem to activate colonic inflammatory cells in a non-specific way, leading to increased production of cytokines, complement-derived peptides, eicosanoids, platelet activating factor, biogenic amines, kinins, chemotactic oligopeptides, and neuropeptides. The named soluble inflammatory mediators, in addition to free oxygen radicals, are considered responsible for the secondary amplification of the inflammatory process. The corner stones in medical therapy of IBD are still corticosteroids and sulphasalazine (SAZ). The new oral salicylates, which are analogues of SAZ or "slow release" preparations of 5-aminosalicylic acid (mesalazine), have provided a therapeutic progress, because they are tolerated better than SAZ. Immunosuppressive agents, such as azathioprine and 6-mercaptopurine, reduce the requirement for corticosteroids and are effective in refractory CD, but the effect is delayed up to several months. The therapeutic action of cyclosporine A is not sustained, but often associated with side effects. Metronidazole has a beneficial effect on perineal disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Structure-activity relation of steroid teratogens. 2. N-Substituted jervines (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-activity relation of steroid teratogens. 2. N-Substituted jervinesDennis Brown and Richard F. KeelerCite this: J. Agric. Food Chem. 1978, 26, 3, 564–566Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/jf60217a069https://doi.org/10.1021/jf60217a069research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Apoptosis in squamous cell carcinoma of the lung: correlation with survival and clinicopathological features (2001)

Anti-ASP staining is a reliable, easy, and sensitive method for assessing apoptosis in tumour sections and confirms the validity of the AI obtained by H&E staining. AI is a guide to the behaviour of SCCs of the lung.