gebhart/patrepeval huggingface dataset:
A federated model for scheduling in wide-area systems (1996)

A model for scheduling in wide area systems is described. The model is federated and utilizes a collection of local site schedulers that control the use of their resources. The wide area scheduler consults the local site schedulers to obtain candidate machine schedules. A set of issues and challenges inherent to wide area scheduling are also described and the proposed model is shown to address many of these problems. A distributed algorithm for wide area scheduling is presented and relies upon information made available about the resource needs of user jobs. The wide area scheduler will be implemented in Legion, a wide area computing system developed at the University of Virginia.
Detection of terahertz waves using low-temperature-grown InGaAs with 1.56μm pulse excitation (2007)

The authors have investigated the dc and terahertz-detection characteristics of the photoconductive antennas made on low-temperature-grown (LTG) InxGa1−xAs (0.4&amp;lt;x&amp;lt;0.53). It was found that the resistivity of the LTG In0.4Ga0.6As can be as high as 700Ωcm, with which the resistance of the antenna becomes higher than 3MΩ. Terahertz waves were detected by the antennas with the pulse excitation at 1.56μm, with a spectral range exceeding 3THz, and a dynamic range of about 55dB. The results also indicate that the photocarrier dynamics depend on the In content.
Selective blockade of membrane attack complex formation during simulated extracorporeal circulation inhibits platelet but not leukocyte activation (1999)

The membrane attack complex, C5b-9, is the major complement determinant of platelet activation during extracorporeal circulation, whereas C5b-9 blockade has little effect on neutrophil activation. These data also suggest a role for platelet activation or C5b-9 (or both) in the loss of monocytes and neutrophils to the extracorporeal circuit.
The Glycogenic Action of Protein Targeting to Glycogen in Hepatocytes Involves Multiple Mechanisms Including Phosphorylase Inactivation and Glycogen Synthase Translocation (2004)

Expression of the glycogen-targeting protein PTG promotes glycogen synthase activation and glycogen storage in various cell types. In this study, we tested the contribution of phosphorylase inactivation to the glycogenic action of PTG in hepatocytes by using a selective inhibitor of phosphorylase (CP-91149) that causes dephosphorylation of phosphorylase a and sequential activation of glycogen synthase. Similar to CP-91194, graded expression of PTG caused a concentration-dependent inactivation of phosphorylase and activation of glycogen synthase. The latter was partially counter-acted by the expression of muscle phosphorylase and was not additive with the activation by CP-91149, indicating that it is in part secondary to the inactivation of phosphorylase. PTG expression caused greater stimulation of glycogen synthesis and translocation of glycogen synthase than CP-91149, and the translocation of synthase could not be explained by accumulation of glycogen, supporting an additional role for glycogen synthase translocation in the glycogenic action of PTG. The effects of PTG expression on glycogen synthase and glycogen synthesis were additive with the effects of glucokinase expression, confirming the complementary roles of depletion of phosphorylase a (a negative modulator) and elevated glucose 6-phosphate (a positive modulator) in potentiating the activation of glycogen synthase. PTG expression mimicked the inactivation of phosphorylase caused by high glucose and counteracted the activation caused by glucagon. The latter suggests a possible additional role for PTG on phosphorylase kinase inactivation.
Aminolysis of 5-Acyl-2,2-dimethyl-1,3-dioxane-4,6-diones (Acyl Meldrum's Acids) as a Versatile Method for the Synthesis of β-Oxo Carboxamides (1992)

5-Acyl-2,2-dimethyl-1,3-dioxane-4,6-diones (acyl Meldrum's acids) underwent aminolysis with various amines to afford the corresponding ß-oxo carboxamides in high yields.
Self-assembled single-crystal silicon circuits on plastic (2006)

We demonstrate the use of self-assembly for the integration of freestanding micrometer-scale components, including single-crystal, silicon field-effect transistors (FETs) and diffusion resistors, onto flexible plastic substrates. Preferential self-assembly of multiple microcomponent types onto a common platform is achieved through complementary shape recognition and aided by capillary, fluidic, and gravitational forces. We outline a microfabrication process that yields single-crystal, silicon FETs in a freestanding, powder-like collection for use with self-assembly. Demonstrations of self-assembled FETs on plastic include logic inverters and measured electron mobility of 592 cm 2 /V-s. Finally, we extend the self-assembly process to substrates each containing 10,000 binding sites and realize 97% self-assembly yield within 25 min for 100-μm-sized elements. High-yield self-assembly of micrometer-scale functional devices as outlined here provides a powerful approach for production of macroelectronic systems.
The role of piezocomposites in ultrasonic transducers (2003)

Combining a piezoelectric ceramic and a passive polymer to form a piezocomposite allows the transducer engineer to design new piezoelectrics that offer substantial advantages over the conventional piezoelectric ceramics and polymers. The rod composite geometry provides materials with enhanced electromechanical coupling and with acoustic impedance close to that of tissue; these factors yield transducers for medical ultrasonic imaging with high sensitivity and compact impulse response. The dice-and-fill technique produces piezocomposites that can be readily formed into complex shapes to facilitate focusing the ultrasonic beam. Proper design of the rod spacing yields materials that exhibit low crosstalk between array elements formed by patterning the electrode alone, without cutting between the elements. In this way, curved annular arrays have been made that provide high-quality clinical images of substantial diagnostic value to physicians. Included is an extensive bibliography of papers documenting the role of piezocomposites in ultrasonic imaging transducers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cystine stones (2007)

Date written: January 2005 Final submission: July 2006
Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease (2006)

In conclusion, these findings point towards a role of inflammation in the form of increased activity of IL-17, IL-6 and IL-8 in patients of unstable angina and acute myocardial infarction and thus suggest that IL-17-driven inflammation may play a role in the promotion of clinical instability in patients with coronary artery disease.
The nesC language (2003)

We present nesC, a programming language for networked embedded systems that represent a new design space for application developers. An example of a networked embedded system is a sensor network, which consists of (potentially) thousands of tiny, low-power "motes," each of which execute concurrent, reactive programs that must operate with severe memory and power constraints.nesC's contribution is to support the special needs of this domain by exposing a programming model that incorporates event-driven execution, a flexible concurrency model, and component-oriented application design. Restrictions on the programming model allow the nesC compiler to perform whole-program analyses, including data-race detection (which improves reliability) and aggressive function inlining (which reduces resource consumption).nesC has been used to implement TinyOS, a small operating system for sensor networks, as well as several significant sensor applications. nesC and TinyOS have been adopted by a large number of sensor network research groups, and our experience and evaluation of the language shows that it is effective at supporting the complex, concurrent programming style demanded by this new class of deeply networked systems.
Introduction of reporter groups at specific sites in DNA containing phosphorothioate diesters (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntroduction of reporter groups at specific sites in DNA containing phosphorothioate diestersJacqueline A. Fidanza and Larry W. McLaughlinCite this: J. Am. Chem. Soc. 1989, 111, 25, 9117–9119Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/ja00207a028https://doi.org/10.1021/ja00207a028research-articleACS PublicationsRequest reuse permissionsArticle Views421Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Resorcylic Acid Lactones. Naturally Occurring Potent and Sclective Inbibitors. (1999)

A resorcylic acid lactone, L-783,277, isolated from a Phoma sp. (ATCC 74403) which came from the fruitbody of Helvella acetabulum, is a potent and specific inhibitor of MEK (Map kinase kinase). L-783,277 inhibits MEK with an IC50 value of 4 nM. It weakly inhibits Lck and is inactive against Raf, PKA and PKC. L-783,277 is an irreversible inhibitor of MEK and is competitive with respect to ATP. L-783,290, the trans-isomer of L-783,277, was isolated from the same culture and evaluated together with several semi-synthetic resorcylic acid lactone analogs. A preliminary structure-activity relationship is presented. Several independent cell-based assays have been carried out to study the biological activities of these resorcylic acid lactone compounds and a brief result summary from these studies is presented.
The Heck Reaction as a Sharpening Stone of Palladium Catalysis (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Heck Reaction as a Sharpening Stone of Palladium CatalysisIrina P. Beletskaya and Andrei V. CheprakovView Author Information Department of Chemistry, Moscow State University, 119899 Moscow, Russia Cite this: Chem. Rev. 2000, 100, 8, 3009–3066Publication Date (Web):July 21, 2000Publication History Received10 January 2000Published online21 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/cr9903048https://doi.org/10.1021/cr9903048research-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views45669Altmetric-Citations3491LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Arylation,Catalysts,Heck reaction,Ligands,Palladium Get e-Alerts
Expression and Secretion of T‐Cell Receptor Vα and Vβ Domains using Escherichia coli as a Host (1991)

An expression system for the production of recombinant T-cell receptor (TCR) variable domains would, inter alia, allow structural studies to be carried out and provide protein for the generation of anti-clonotypic antibodies. In this report the V alpha and V beta domain genes have been isolated from a T-cell hybridoma which is associated with the pathogenesis of experimental allergic encephalomyelitis (EAE) in the H-2u mouse. These have been expressed as secreted domains in Escherichia coli, using secretion vectors previously used for the production of immunoglobulin fragments. Both V alpha and V beta domains are secreted in milligram quantities into the culture supernatant, although the levels of the V alpha domain are about 10-20 fold higher than those of the V beta domain. This expression system offers a rapid route for the production of recombinant TCRs in soluble form.
Determination of the origin of the N‐terminal pyro‐glutamate variation in monoclonal antibodies using model peptides (2006)

The purpose of this work is to determine the cause of the cyclization of the N-terminal glutamine in recombinant proteins and monoclonal antibodies. This cyclization reaction commonly occurs on the N-terminal of light and/or heavy chains of antibodies and leads to heterogeneity of the final product. Two model peptides and an antibody containing an N-terminal glutamine were used to investigate the formation of N-terminal pyro- glutamic acid under various experimental conditions and different stages of the biosynthetic process. LC-MS analysis was used to separate and quantify the N-terminal variants. Experiments prove that the cyclization reaction is spontaneous and highly dependent on temperature and buffer composition and less dependent on pH. The conditions presented in most biopharmaceutical processes accelerate the formation of this variant. The majority of the near complete conversion (>95%) of N-terminal glutamine to pyro-glutamic acid commonly observed for antibodies appears to occur inside the bioreactor with only a small contribution from purification, formulation, and analytical preparation.
New pathogenetic insights into the sarcoid granuloma (2000)

Although the most important enigma of sarcoidosis, ie, its etiology, remains an unsolved problem, the past few years have seen remarkable advances in understanding general immunologic and molecular aspects of the mechanisms leading to granuloma formation in sarcoidosis. It is now clear that during the sarcoid inflammatory process several cytokines are secreted at sites of disease activity; in addition, high affinity receptors for cytokines participating in the granuloma development have been recently identified. This article provides a detailed description of recent data that have clarified cellular interactions governing the dynamics of granuloma formation in sarcoidosis. Together, these new results provide important insights that can refocus efforts at developing immunotherapeutic methods of inhibiting cytokine production at sites of granuloma formation.
Determination of the gene sequence and the molecular structure of the enterococcal peptide antibiotic AS-48 (1994)

The structural gene of the enterococcal peptide antibiotic AS-48 (as-48) has been identified and cloned by using two degenerate 17-mer DNA oligonucleotides on the basis of the amino acid sequences of two peptides obtained by digestion of the antibiotic with Glu-C endoproteinase. That as-48 gene codes for a 105-amino-acid prepeptide, giving rise to a 70-amino-acid mature protein. Comparative analysis demonstrated that the 16-amino-acid sequence of one of the AS-48 Glu-C peptides, designated V8-5, was composed of a 12-amino-acid sequence corresponding to the C-terminal end sequence (from isoleucine +59 to tryptophan +70 [I+59 to W+70]) of the prepeptide and terminated in four residues forming the N terminus (M+1 to E+4) of a putative AS-48 propeptide. These data, combined with the characteristics of the gene sequence, strongly suggested that the antibiotic peptide was a 70-residue cyclic molecule. We propose that the AS-48 translated primary product is very likely submitted to a posttranslational modification during secretion (i) by an atypical or a typical signal peptidase that cleaves off a 35-residue or shorter signal peptide, respectively, from the prepeptide molecule and (ii) by the linkage of the methionine residue (M+1) to the C-terminal tryptophan residue (W+70) to obtain the cyclic peptide (a tail-head linkage).
Practice-Related Improvement in Working Memory is Modulated by Changes in Processing External Interference (2009)

Working memory (WM) performance is impaired by the presence of external interference. Accordingly, more efficient processing of intervening stimuli with practice may lead to enhanced WM performance. To explore the role of practice on the impact that interference has on WM performance, we studied young adults with electroencephalographic (EEG) recordings as they performed three motion-direction, delayed-recognition tasks. One task was presented without interference, whereas two tasks introduced different types of interference during the interval of memory maintenance: distractors and interruptors. Distractors were to be ignored, whereas interruptors demanded attention based on task instructions for a perceptual discrimination. We show that WM performance was disrupted by both types of interference, but interference-induced disruption abated across a single experimental session through rapid learning. WM accuracy and response time improved in a manner that was correlated with changes in early neural measures of interference processing in visual cortex (i.e., P1 suppression and N1 enhancement). These results suggest practice-related changes in processing interference exert a positive influence on WM performance, highlighting the importance of filtering irrelevant information and the dynamic interactions that exist between neural processes of perception, attention, and WM during learning.
Predicting the clinical status of human breast cancer by using gene expression profiles (2001)

Prognostic and predictive factors are indispensable tools in the treatment of patients with neoplastic disease. For the most part, such factors rely on a few specific cell surface, histological, or gross pathologic features. Gene expression assays have the potential to supplement what were previously a few distinct features with many thousands of features. We have developed Bayesian regression models that provide predictive capability based on gene expression data derived from DNA microarray analysis of a series of primary breast cancer samples. These patterns have the capacity to discriminate breast tumors on the basis of estrogen receptor status and also on the categorized lymph node status. Importantly, we assess the utility and validity of such models in predicting the status of tumors in crossvalidation determinations. The practical value of such approaches relies on the ability not only to assess relative probabilities of clinical outcomes for future samples but also to provide an honest assessment of the uncertainties associated with such predictive classifications on the basis of the selection of gene subsets for each validation analysis. This latter point is of critical importance in the ability to apply these methodologies to clinical assessment of tumor phenotype.
Stimulation of Measles Virus Replication by Cyclic Guanosine Monophosphate (1991)

Measles virus (MV) replication in acutely infected human cells was markedly stimulated following exposure to guanosine 3',5'-monophosphate (cyclic GMP). Addition of cyclic GMP to tissue culture fluids immediately following infection with the virus resulted in acceleration of virus-mediated cell fusion, increased synthesis of virus-specified proteins and a 50-fold increase in infectious particle production. No evidence of altered viral protein phosphorylation was found. The results suggest that cyclic GMP stimulates multiple stages of the MV replication cycle.
Apparent Ionization Exponents of 4-Hydroxyquinoline, 4-Methoxyquinoline and N-Methyl-4-quinolone; Evaluation of Lactam—Lactim Tautomerism1 (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApparent Ionization Exponents of 4-Hydroxyquinoline, 4-Methoxyquinoline and N-Methyl-4-quinolone; Evaluation of Lactam—Lactim Tautomerism1Gabriel F. Tucker Jr. and J. Logan IrvinCite this: J. Am. Chem. Soc. 1951, 73, 5, 1923–1929Publication Date (Print):May 1, 1951Publication History Published online1 May 2002Published inissue 1 May 1951https://pubs.acs.org/doi/10.1021/ja01149a006https://doi.org/10.1021/ja01149a006research-articleACS PublicationsRequest reuse permissionsArticle Views246Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural modulations of the envelope gp120 glycoprotein of human immunodeficiency virus type 1 upon oligomerization and differential V3 loop epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor binding (1995)

We investigated the binding of conformation-dependent anti-V2, anti-V3, and anti-CD4-binding site monoclonal antibodies to monomeric and virion-associated gp120 from human immunodeficiency virus type 1 isolates displaying marked differences in cell tropism. For all viruses examined, we found that the half-maximal binding values of the anti-V2 and anti-CD4-binding site antibodies with virion-associated gp120 were higher than those with monomeric gp120, but the maximum amount of antibodies bound was diminished only for one of the anti-V2 antibodies tested. These observations suggest that upon gp120 oligomerization, the V2 loop and CD4-binding site undergo conformational changes and that particular epitopes within these domains are occluded in the oligomeric gp120. In contrast, although the overall binding patterns and half-maximal binding values of the anti-V3 loop antibodies tested were similar with monomeric and oligomeric gp120, all the V3 loop epitopes examined were less accessible to antibody binding on the virion surface. This masking of the V3 loop is more pronounced for the primary-like macrophage-tropic isolates examined. Lastly, we observe that upon soluble receptor-virion binding, specific V3 loop epitopes that differ for viruses displaying different tropisms are exposed.