gebhart/patrepeval huggingface dataset:
Bacteriophages for Plant Disease Control (2007)

The use of phages for disease control is a fast expanding area of plant protection with great potential to replace the chemical control measures now prevalent. Phages can be used effectively as part of integrated disease management strategies. The relative ease of preparing phage treatments and low cost of production of these agents make them good candidates for widespread use in developing countries as well. However, the efficacy of phages, as is true of many biological control agents, depends greatly on prevailing environmental factors as well as on susceptibility of the target organism. Great care is necessary during development, production and application of phage treatments. In addition, constant monitoring for the emergence of resistant bacterial strains is essential. Phage-based disease control management is a dynamic process with a need for continuous adjustment of the phage preparation in order to effectively fight potentially adapting pathogenic bacteria.
Overview of gene therapy clinical progress including cancer treatment with gene-modified T cells (2009)

It is now twenty years since the first legal gene transfer studies were approved, and there has been considerable disappointment in the slow rate of progress that followed the initial studies. Gradually, however, as the limitations of available vectors are acknowledged and overcome, and with advances in our understanding of the molecular and cell biology of genetic diseases and of cancer, unequivocal successes are now being reported. In this paper we describe the remaining major roadblocks to successful gene therapy and outline approaches to overcome them. We also illustrate how genetically modified immune system cells are already being used for the effective treatment of hematological and other malignancies, and how these approaches are being modified so that they can be effective in treating a broader range of malignancies.
Multilayered Carbon Nanotube/Polymer Composite Based Thermoelectric Fabrics (2012)

Thermoelectrics are materials capable of the solid-state conversion between thermal and electrical energy. Carbon nanotube/polymer composite thin films are known to exhibit thermoelectric effects, however, have a low figure of merit (ZT) of 0.02. In this work, we demonstrate individual composite films of multiwalled carbon nanotubes (MWNT)/polyvinylidene fluoride (PVDF) that are layered into multiple element modules that resemble a felt fabric. The thermoelectric voltage generated by these fabrics is the sum of contributions from each layer, resulting in increased power output. Since these fabrics have the potential to be cheaper, lighter, and more easily processed than the commonly used thermoelectric bismuth telluride, the overall performance of the fabric shows promise as a realistic alternative in a number of applications such as portable lightweight electronics.
Electrically-activated, normally-closed diaphragm valves (2002)

Electrically activated, normally closed diaphragm valves have been fabricated using heated bimetallic diaphragms to provide the operating force. These valves have been designed to provide fully proportional control of flows in the range of 0-150 cm/sup 3//min at input pressures between 1 and 50 PSIG. The valves are batch-fabricated using silicon micromachining techniques. By combining these valves with pressure or flow sensing elements, closed-loop pressure or flow control is easily accomplished.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Introduction to Laser Diode-Pumped Solid State Lasers (2002)

Part I Fundamentals of Laser Diode Pumping: Introduction Basic Concepts. Part II Basic End-pumped Laser Design: Design of a TEM00 Continuous-Wave Diode-pumped Nd YAG Laser Operation of the Continuous-Wave Diode-pumped Laser. Part III Advanced Concepts for Diode Pumping: Power Scaling Considerations Side-pumped Designs Other Output Wavelengths for Nd-doped Lasers Diodes for Pumping Other Gain Elements Examples of Other Diode-pumped Lasers Intracavity Elements: Q-switching, SHG and Single-Longitudinal-Mode Operation.
Satellite cell numbers in young and older men 24 hours after eccentric exercise (2005)

We tested the hypothesis that the expansion of satellite cell numbers, 24 h after maximal eccentric knee extensor exercise, is blunted in older men. Muscle biopsies were obtained from the vastus lateralis of 10 young (23-35 years) and 9 older (60-75 years) men. Satellite cells were identified immunohistochemically using an antibody to neural cell adhesion molecule. After 92 maximal eccentric contractions, the mean number of satellite cells per muscle fiber increased to a greater extent among the young men (141%; P < 0.001) than older men (51%; P = 0.002) from preexercise levels. Similar results were obtained when satellite cells were expressed as a proportion of all sublaminar nuclei. We conclude that a single bout of maximal eccentric exercise increases satellite cell numbers in both age groups, with a significantly greater response among the young men. These data suggest that age-related changes in satellite cell recruitment may contribute to muscle regeneration deficits among the elderly.
Multiprocessors and run‐time compilation (1991)

Abstract Run‐time preprocessing plays a major role in many efficient algorithms in computer science, as well as playing an important role in exploiting multiprocessor architectures. We give examples that elucidate the importance of run‐time preprocessing and show how these optimizations can be integrated into compilers. To support our arguments, we describe transformations implemented in prototype multiprocessor compilers and present benchmarks from the iPSC2/860, the CM‐2 and the Encore Multimax/320.
Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analogue - 9-(S)-(2,3-dihydroxypropyl)adenine (1980)

9-( S )-(2,3-Dihydroxypropyl)adenine, a nucleoside analogue with antiviral activity, inhibits the hydrolysis of S -adenosyl-L-homocysteine catalyzed by rat liver S -adenosyl-L-homocysteine hydrolase ( K i = 3.5 μM; K i / K m = 5.6 . 10 -2 ). The effect upon the synthesis of the substrate is much less pronounced.
Vacuum Assisted Closure for the Treatment of Sternal Wounds: The Bridge between Débridement and Definitive Closure (2003)

A method to refine the treatment of sternal wounds using Vacuum Assisted Closure (V.A.C.) therapy as the bridge between débridement and delayed definitive closure is described. A retrospective review of 35 consecutive patients with sternal wound complications over a 2-year period (March of 1999 to March of 2001) was performed. The treatment of sternal wounds with traditional twice-a-day dressing changes was compared with the treatment with the wound V.A.C. device. An analysis of the number of days between initial débridement and closure, number of dressing changes, number and types of flaps needed for reconstruction, and complications was performed. Eighteen patients were treated with traditional twice-a-day dressing changes and 17 patients were treated with V.A.C. therapy alone. The two groups were similar regarding age, sex, type of cardiac procedure, and type of sternal wound. The V.A.C. therapy group had a trend toward a shorter interval between débridement and closure, with a mean of 6.2 days, whereas the dressing change group had mean of 8.5 days. The V.A.C. therapy group had a significantly lower number of dressing changes, with a mean of three, whereas the twice-a-day dressing change group had a mean of 17 (p < 0.05). Reconstruction required an average of 1.5 soft-tissue flaps per patient treated with traditional dressing changes versus 0.9 soft-tissue flaps per patient for those treated with V.A.C. therapy (p < 0.05). Before closure, there was one death among patients undergoing dressing changes and three in the V.A.C. therapy group, all of which were unrelated to the management of the sternal wound. Patients with sternal wounds who have benefited from V.A.C. therapy alone have a significant decrease in the number of dressing changes and number of soft-tissue flaps needed for closure. Finally, the V.A.C. therapy group had a trend toward a decreased number of days between débridement and closure.
Multimerization of Adenovirus Serotype 3 Fiber Knob Domains Is Required for Efficient Binding of Virus to Desmoglein 2 and Subsequent Opening of Epithelial Junctions (2011)

Recently, we identified desmoglein 2 (DSG2) as the main receptor for a group of species B adenoviruses (Ads), including Ad3, a serotype that is widely distributed in the human population (H. Wang et al., Nat. Med. 17:96-104, 2011). In this study, we have attempted to delineate structural details of the Ad3 interaction with DSG2. For CAR- and CD46-interacting Ad serotypes, attachment to cells can be completely blocked by an excess of recombinant fiber knob protein, while soluble Ad3 fiber knob only inefficiently blocks Ad3 infection. We found that the DSG2-interacting domain(s) within Ad3 is formed by several fiber knob domains that have to be in the spatial constellation that is present in viral particles. Based on this finding, we generated a small recombinant, self-dimerizing protein containing the Ad3 fiber knob (Ad3-K/S/Kn). Ad3-K/S/Kn bound to DSG2 with high affinity and blocked Ad3 infection. We demonstrated by confocal immunofluorescence and transmission electron microscopy analyses that Ad3-K/S/Kn, through its binding to DSG2, triggered the transient opening of intercellular junctions in epithelial cells. The pretreatment of epithelial cells with Ad3-K/S/Kn resulted in increased access to receptors that are localized in or masked by epithelial junctions, e.g., CAR or Her2/neu. Ad3-K/S/Kn treatment released CAR from tight junctions and thus increased the transduction of epithelial cells by a serotype Ad5-based vector. Furthermore, the pretreatment of Her2/neu-positive breast cancer cells with Ad3-K/S/Kn increased the killing of cancer cells by the Her2/neu-targeting monoclonal antibody trastuzumab (Herceptin). This study widens our understanding of how Ads achieve high avidity to their receptors and the infection of epithelial tissue. The small recombinant protein Ad3-K/S/Kn has practical implications for the therapy of epithelial cancer and gene/drug delivery to normal epithelial tissues.
Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs (2016)

Vascular endothelial growth factor (VEGF) inhibition has been demonstrated to be an effective strategy in preserving the integrity of the blood-brain barrier (BBB) in patients with acute ischemic stroke. Loss of the BBB is the key event associated with morbidity and mortality in these patients. However, the underlying mechanisms remain poorly understood. In the present study, the effects of VEGF inhibition and the possible mechanism that underlies acute cerebral ischemia in rats was investigated. Following the induction of transient middle cerebral artery occlusion for a 90‑min period, either an anti‑VEGF neutralizing antibody (RB‑222; 5 or 10 µg), or IgG (control), was administered by intracerebroventricular injection at 1 h following reperfusion. Functional outcomes, BBB leakage, brain edema, microvessel numbers and the relative protein levels of VEGF, matrix metalloproteinase (MMP)-2, MMP-9, occludin and collagen-IV were then determined using neurological assessments, Evans Blue staining, brain water content, CD31 staining and western blotting. Treatment with RB‑222 at a dose of 5 and 10 µg significantly improved neurological functional outcomes and diminished infarct size, BBB leakage and brain edema compared with the MCAO and IgG groups at 24 h following reperfusion; 10 µg RB‑222 was more effective than a 5 µg dose of the antibody. In addition, RB‑222 reduced the number of immature microvessels, which subsequently attenuated BBB permeability. RB‑222 significantly repressed VEGF expression as well as decreased MMP‑2 and MMP‑9 expression. However, it enhanced occludin and collagen‑IV levels in the ischemic rat brain compared with the MCAO and IgG groups. Taken together, the results indicate that early inhibition of VEGF may have significant potential against cerebral ischemia, partly by regulating the expression of MMPs.
Sensor physical unclonable functions (2010)

We propose a novel variety of sensor that extends the functionality of conventional physical unclonable functions to provide authentication, unclonability, and verification of a sensed value. This new class of device addresses the vulnerability in typical sensing systems whereby an attacker can spoof measurements by interfering with the analog signals that pass from the sensor element to the embedded microprocessor. The concept can be applied to any type of analog sensor.
Pitch prediction filters in speech coding (1989)

Prediction error filters which combine short-time prediction (formant prediction) with long-time prediction (pitch prediction) in a cascade connection are examined. A number of different solution methods (autocorrelation, covariance, Burg) and implementations (transversal and lattice) are considered. It is found that the F-P cascade (formant filter before the pitch filter) outperforms the P-F cascade for the both transversal- and lattice-structured predictors. The performances of the transversal and lattice forms are similar. The solution method that yields a transversal structure requires a stability test and, if necessary, a consequent stabilization. The two cascade forms are implemented as part of an APC coder to evaluate their relative subjective performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Enhanced Immunogenicity of the Pre-S Region of Hepatitis B Surface Antigen (1985)

The 55 codons upstream of the gene sequence encoding the hepatitis B surface antigen (HBsAg) are called the pre-S(2) region. It has been proposed that polypeptides of high molecular weight that contain the pre-S(2) region should be included in future hepatitis B virus (HBV) vaccines. The pre-S(2) region and the S gene product [25 kilodalton (kD)] together compose a polypeptide of high molecular weight (33 kD). As an initial attempt to determine the relevance of the 33-kD polypeptide to development of an HBV vaccine, the murine immune response to pre-S(2)-encoded determinants as compared to S-encoded determinants on the same polypeptide was examined. The results indicate (i) the pre-S(2) region is significantly more immunogenic than the S region of HBsAg, (ii) the 26 amino acid residues at the NH2-terminus of the 33-kD polypeptide represent a dominant antibody binding site on the pre-S(2) region, (iii) the immune response to the pre-S(2) region is regulated by H-2-linked genes distinct from those that regulate the response to the S region, and (iv) immunization of an S region nonresponder strain with HBV envelope particles that contain both the pre-S(2) and S regions can circumvent nonresponsiveness to the S region.
Spike-based Learning Rules and Stabilization of Persistent Neural Activity (1999)

We analyze the conditions under which synaptic learning rules based on action potential timing can be approximated by learning rules based on firing rates. In particular, we consider a form of plasticity in which synapses depress when a presynaptic spike is followed by a postsynaptic spike, and potentiate with the opposite temporal ordering. Such differential anti-Hebbian plasticity can be approximated under certain conditions by a learning rule that depends on the time derivative of the postsynaptic firing rate. Such a learning rule acts to stabilize persistent neural activity patterns in recurrent neural networks. 1 INTRODUCTION 0 A 0 0 t post - t pre B C pre post 0 1000 2000 0.5 1 time (ms) weight Figure 1: (A) Pairing function for differential Hebbian learning. The change in synaptic strength is plotted versus the time difference between postsynaptic and presynaptic spikes. (B) Pairing function for differential anti-Hebbian learning. (C) Differential anti...
Polysaccharides from Lichens: Structural Characteristics and Biological Activity (2001)

Lichens have been used for medicinal purposes throughout the ages, and beneficial claims have to some extent been correlated with their polysaccharide content. Of 13,500 lichen species growing worldwide, less than 100 species have been investigated for polysaccharide content. Lichen polysaccharides are mainly of three different structural types: beta-glucans, alpha-glucans, and galactomannans. In addition, a few complex heteroglycans have recently been described, such as thamnolan, a water-soluble, immunologically active heteroglycan with a novel rhamnopyranosylgalactofuranan type of structure. A number of investigations have been carried out on biological effects of lichen polysaccharides, most notably antitumour, immunomodulating, antiviral, and memory-enhancing effects. The current review summarizes present knowledge on the structural characteristics and biological activity of lichen polysaccrides.
Laminated media for high-density recording (1993)

The magnetic recording properties of laminated media structures on hard disks are discussed, including an overview of work on this topic. The primary performance advantage of laminated media is a significant reduction in media noise. The various mechanisms proposed for this noise reduction are considered. Other issues discussed include the optimal properties for the nonmagnetic interlayers, the influence of lamination on bulk magnetic properties, soft error rate measurements, and process challenges. The most important mechanism for the improved performance that has been obtained is decoupling of the noise sources in the various layers. The optimum interlayer thickness is in the range of 20-50 AA and seems to depend on the sputtering system and process conditions used.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Real Economic Activity and Stock Prices in A small Developing Economy:The case of Malysia (2000)

The present paper analyzes the ability of the stock prices to anticipate future variations in real industrial production using a Granger-style output forecasting equation. The analysis carefully considers the trend properties of the data by. a priori, implementing tests for integration, cointegration and trends. The results indicate only a limited role of the stock prices as a leading indicator for real output. Accordingly, the movements in the stock prices should be regarded as providing only a general information and should not be relied upon. excessively to gauge future economic conditions
Perioperative use of eicosapentaenoic acid and patency of infrainguinal vein bypass: A retrospective chart review (2007)

Although graft diameter was the most important factor for long-term patency of infrainguinal vein bypass grafts, the perioperative use of EPA significantly improved primary patency among these subjects.
Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study (2011)

Ofatumumab, the human CD20 monoclonal antibody that binds a distinct epitope from rituximab, has demonstrated clinical benefit as monotherapy for patients with chronic lymphocytic leukemia refractory to fludarabine and alemtuzumab (FA-ref) and patients refractory to fludarabine with bulky (> 5 cm) lymph nodes (BF-ref). To potentially gain insight into outcomes in patients previously treated with or refractory to rituximab, we performed an ad hoc retrospective analysis in the final 96 FA-ref and 111 BF-ref patients. There were 117 patients previously treated with rituximab (98 rituximab-refractory); 89 patients were rituximab-naive. For rituximab-treated, rituximab-refractory, and rituximab-naive patients, overall response rate was 43%, 44%, and 53%; median progression-free survival was 5.3, 5.5, and 5.6 months; and median overall survival was 15.5, 15.5, and 20.2 months. There were no significant differences in ofatumumab-related infusion reactions, or hematologic or infectious adverse events between subgroups. In summary, ofatumumab monotherapy was effective and well tolerated in patients with fludarabine-refractory chronic lymphocytic leukemia, including in patients with previous rituximab exposure. This trial was registered at www.clinicaltrials.gov as #NCT00349349.
Conformational Characteristics of the Trinucleoside Diphosphate dApdApdA and Its Constituents from Nuclear Magnetic Resonance and Circular Dichroism Studies (1980)

Proton NMR studies at 360 MHz were carried out on the trinucleoside diphosphate dApdApdA, the dinucleoside monophosphate dApdA and the methylphosphate esters of the monomers pdA, pdAp and dAp. The compounds were also investigated by means of circular dichroism at varying temperatures. Complete NMR spectral assignments are given. The thermodynamics of stacking derived from the circular dichroic spectra was used to extrapolate the observed coupling constants, measured at a range of temperatures, to values appropriate to the pure stacked states of the dimer and the trimer. The data were interpreted in terms of the N and S deoxyribose pseudorotational ranges [Altona, C. and Sundaralingam, M. (1972) J. Am. Chem. Soc. 94, 8205--8212] and it is shown that the right-handed single helix of the trimer occurs in two distinct forms: the major one corresponds to a B-DNA-like structure, S-S-S; the minor one (30%) has the sugar rings in a hitherto unsuspected S-S-N conformational sequence. The dimer behaves quite similarly, a mixture of 70% S-S and 30% S-N stacks being indicated. The detailed geometry of teh S-type sugar rings is not invariable but appears to undergo a slight shift when another base stacks on top of a given nucleotide unit. The backbone angles of the fully stacked B-DNA-like single helix in solution are (starting the notation at P) beta = 187 degrees, gamma = 50 degrees, delta = 138 degrees, epsilon = 186 degrees.
Multi-agent reinforcement learning for traffic signal control (2014)

Optimal control of traffic lights at junctions or traffic signal control (TSC) is essential for reducing the average delay experienced by the road users amidst the rapid increase in the usage of vehicles. In this paper, we formulate the TSC problem as a discounted cost Markov decision process (MDP) and apply multi-agent reinforcement learning (MARL) algorithms to obtain dynamic TSC policies. We model each traffic signal junction as an independent agent. An agent decides the signal duration of its phases in a round-robin (RR) manner using multi-agent Q-learning with either ε-greedy or UCB [3] based exploration strategies. It updates its Q-factors based on the cost feedback signal received from its neighbouring agents. This feedback signal can be easily constructed and is shown to be effective in minimizing the average delay of the vehicles in the network. We show through simulations over VISSIM that our algorithms perform significantly better than both the standard fixed signal timing (FST) algorithm and the saturation balancing (SAT) algorithm [15] over two real road networks.
Semi‐Automated method of analysis of horizontal histological sections of skin for objective evaluation of fractional devices (2009)

The proposed methodology provides a comprehensive, objective, and efficient approach for the comparison of various fractional devices. Correlation of device settings with the objective dimensions of post-treatment damage profiles serve as a powerful tool for the prediction and modulation of clinical response.