gebhart/patrepeval huggingface dataset:
Angiogenesis in inflammatory joint disease: a target for therapeutic intervention (2000)

SUMMARY The evidence reviewed here clearly supports the concept that pathological angiogenesis is an important component in inflammatory joint erosion. Of the primary angiogenic factors, VEGF-A is clearly a key participant in this mechanism and a range of anti-VEGF strategies is being developed to neutralize its biological function [54,55]. Currently available drugs are also being screened for VEGF antagonistic effects. In a study of the effects of existing disease-modifying anti-rheumatic drugs on cultured synovial cells, bucillamine and dexamethasone showed significant inhibition of VEGF production [56]. In addition, COX-1 and COX-2 non-steroidal anti-inflammatory drugs have been shown to inhibit angiogenesis by blocking VEGF-induced signal transduction [57]. Modulation of the immune network in RA using TNF-α antagonists is producing promising results, but as outlined in this review, this treatment on its own is unlikely to control joint angiogenesis. It is possible that combination therapy, e.g. TNF-α antagonist and a VEGF signal transduction inhibitor, will be more effective by using antagonists that block different but key control points in the disease pathology.
Infinite coordination polymer nano- and microparticle structures (2009)

Infinite coordination polymer particles (ICPs) represent an area of growing interest in chemistry and materials science due to their unique and highly tailorable properties. These structures can be conveniently synthesized in high yields from the appropriate metal salts and bifunctional ligand precursors. Unlike conventional metal-organic framework materials (MOFs), these ICPs exhibit a higher level of structural tailorability, including size- and morphology-dependent properties, and therefore, the promise of a wider scope of utility. A variety of methods now exist for making numerous compositions, with modest control over particle size and shape. These structures can exhibit microporosity, tunable fluorescence, magnetic susceptibility, and unusual catalytic activity and selectivity. Perhaps most importantly, many of these ICP structures can be depolymerized (sometimes reversibly) much faster and under milder conditions than MOFs, which makes them attractive for a variety of biomedical applications. Thus far, several types of ICPs have been explored as contrast agents for magnetic resonance imaging and drug delivery systems. The groundwork for this emerging field of ICPs has been laid only in the past few years, yet significant advances have already been made. Indeed, this tutorial review introduces the reader to the field of ICPs, providing a guide to the work done so far, with an emphasis on synthesis, applications and future prospects.
Aminoacyl Transfer RNA Synthetases: General Scheme Of Structure Function Relationships In The Polypeptides And Recognition Of Transfer-RNAs (1987)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Self-Optimization of Coverage and Capacity in LTE using Adaptive Antenna Systems (2010)

In cellular radio networks, the selection of antenna parameters and techniques for antennas plays a key role for capacity and coverage area. Not only network performance is affected by suboptimal network planning but also it is affected by the dynamic radio environment. Therefore, antenna parameters should be adjusted adaptively. Since reacting to the changed situation manually is very expensive and time consuming, The Third Generation Partnership Project (3GPP) introduced the Coverage and Capacity Optimization (CCO) use case for Long Term Evolution (LTE) under the topic of Self-Organizing Network (SON). This thesis work provides a detailed analysis of the optimization space of antenna parameters and compares different tilt techniques as well as discusses vertical sectorization as a novel capacity optimization approach. The work continues by further focusing on the self optimization of coverage and capacity using Adaptive Antenna Systems (AAS) on the basis of findings in the previous simulations on antenna parameters. Evaluations are performed by mapping link-level simulation results into a system level LTE simulator that models antennas in details and propagation in three dimensions.
Dorsal root ganglion &ndash; a potential new therapeutic target for neuropathic pain (2012)

A regional approach can protect our patients from often unacceptable adverse effects produced by systematically applied drugs. Regional therapeutic approaches, as well as interventions at the level of the peripheral nervous system and particularly the dorsal root ganglion (DRG), represent an alternative to the systemic application of therapeutic agents. This article provides an overview of DRG anatomical peculiarities, explains why the DRG is an important therapeutic target, and how animal models of targeted drug delivery can help us in the translation of basic research into clinical practice.
Linear viscoelastic behavior of subcutaneous adipose tissue (2008)

Subcutaneous adipose tissue contributes to the overall mechanical behavior of the skin. Until today, however, no thorough constitutive model is available for this layer of tissue. As a start to the development of such a model, the objective of this study was to measure and describe the linear viscoelastic behavior of subcutaneous adipose tissue. Although large strains occur in vivo, this work only focuses on the linear behavior to show the applicability of the described methods to adipose tissue. Shear experiments are performed on porcine samples on a rotational rheometer using parallel plate geometry. In the linear viscoelastic regime, up to 0.1% strain, the storage and loss modulus showed a frequency- and temperature-dependent behavior. The ratio between the two moduli, the phase angle, did not show any dependency on temperature and frequency. The shear modulus was found to be 7.5 kPa at 10 rad/s and 37 degrees C. Time-temperature superposition was applicable through shifting the shear modulus horizontally. A power-law function model was introduced to describe both the frequency dependent behavior at constant temperature and the stress relaxation behavior. In addition, the effect of snap freezing as a preservation method was analyzed. Histological examination demonstrated possible tissue damage after freezing, but the mechanical properties did not change. Since results were reproducible, it is concluded that the methods we used are most probably suited to explore the non-linear behavior of subcutaneous adipose tissue.
Context-based and Explainable Decision Making with Argumentation (2018)

Argumentation-based approaches to decision making have gained considerable research interest, due to their ability to select and justify decisions. In order to make better decisions, context is a key piece of information that needs to be considered. However, most existing argumentation-based models and frameworks have not modelled or reasoned with context explicitly. In this paper, we present a new argumentation-based approach for making context-based and explainable decisions. We propose a graphical representation for modelling decision problems involving varying contexts, Decision Graphs with Context (DGC), and a reasoning mechanism for making context-based decisions which relies on the Assumption-based Argumentation formalism. Based on these constructs, we introduce two types of explanations, argument explanation and context explanation , identifying the reasons for the decisions made from an argument-view and a context-view respectively.
Single-stage input-current-shaping technique with voltage-doubler-rectifier front end (2001)

In this paper, a new single-stage input-current-shaping (S/sup 2/ICS) technique that integrates the voltage-doubler-rectifier front end with a DC/DC output stage is introduced. Due to the voltage-doubler-rectifier front end, a reduction of line-current harmonics can be achieved with a higher conversion efficiency compared to the corresponding S/sup 2/ICS circuit with the conventional wide-range full-bridge rectifier. The proposed technique requires energy-storage capacitors with the same total capacitance and with half of the voltage rating as in the conventional S/sup 2/ICS counterpart, which reduces the size and cost of the power supply. The performance of the proposed technique is evaluated on a 450 W (5 V/90 A) experimental prototype circuit.
Smoking, sex of the offspring, and risk of placental abruption, placenta previa, and preeclampsia: a population-based cohort study (2001)

: Female fetuses are more vulnerable than male to the negative effect of maternal smoking on placenta previa.
Effectiveness of rehabilitation for multiple sclerosis (1999)

Unlike other areas of rehabilitation, which typically follow a single incident such as trauma or stroke and are followed by improvement (or at least an expectation of stable impairment), multiple sclerosis (MS) presents the problem of progressive impairment and disability. In addition the nature and course of this progression are variable, so that the population is heterogeneous. Expectations for outcome must be modest, and measurement should be focused on quality on life issues. On a background of pre-existing complex disability, multiple single-case (before and after) study designs often present the best evidence for effectiveness of the team approach and for specific interventions. This evidence is presented and reviewed.
Taste Perception: Cracking the Code (2004)

Our sense of taste begins with taste buds and ends in the brain. Researchers are beginning to unravel the mechanisms and connections that lie in between
THE CHURCH OF ENGLAND (2013)

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Animal models of acute lung injury (2008)

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.
Structure and stereochemistry 4a.beta.,7.alpha.,7a.beta.-nepetalactone from Nepeta mussini and its relationship to the 4a.alpha.,7.alpha.,7a.alpha.- and 4a.alpha.,7.alpha.,7a.beta.-nepetalactones from N. cataria (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and stereochemistry 4a.beta.,7.alpha.,7a.beta.-nepetalactone from Nepeta mussini and its relationship to the 4a.alpha.,7.alpha.,7a.alpha.- and 4a.alpha.,7.alpha.,7a.beta.-nepetalactones from N. catariaEdmund J. Eisenbraun, Clinton E. Browne, Rebecca L. Irvin-Willis, Donald J. McGurk, Ernest L. Eliel, and David L. HarrisCite this: J. Org. Chem. 1980, 45, 19, 3811–3814Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/jo01307a016https://doi.org/10.1021/jo01307a016research-articleACS PublicationsRequest reuse permissionsArticle Views369Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human papillomavirus type 16/18 in uterine cervical adenocarcinomain situ and adenocarcinoma a study byin situ hybridization with biotinylated DNA probes (1990)

The distribution of human papillomavirus (HPV) DNA type 16/18 in the paraffin sections of 11 adenocarcinomas (AC), 4 adenocarcinomas in situ (AIS), and 2 adenosquamous carcinomas (AC/SCC) of the cervix was examined by in situ hybridization (ISH) with biotinylated DNA probes (B-probes). Four AC, four AIS, and one AC/SCC were positive. These results show that B-probes are an acceptable alternative to both ISH with radiolabeled probes and Southern blot hybridization (SBH), which are difficult to apply in routine pathologic laboratories. Cervical tissues infiltrated with endometrial AC were negative for HPV DNA 16/18, and it is suggested that the presence of HPV DNA 16/18 in uterine AC may be helpful in discriminating cervical AC from endometrial AC.
Synergistic Interactions Between In-Hive Miticides in <I>Apis mellifera</I> (2009)

The varroa mite, Varroa destructor Anderson & Trueman, is a devastating pest of honey bees, Apis mellifera L., that has been primarily controlled over the last 15 yr with two in-hive miticides: the organophosphate coumaphos (Checkmite+), and the pyrethroid tau-fluvalinate (Apistan). Both coumaphos and tau-fluvalinate are lipophilic compounds that are absorbed by the wax component of the hive, where they are stable and have the potential to build up over repeated treatments such that bees could be exposed to both compounds simultaneously. Although these compounds were chosen as in-hive miticides due to their low toxicity to honey bees, that low toxicity depends, at least in part, on rapid detoxification mediated by cytochrome P450 monooxygenase enzymes (P450s). In this laboratory study, we observed a large increase in the toxicity of tau-fluvalinate to 3-d-old bees that had been treated previously with coumaphos, and a moderate increase in the toxicity of coumpahos in bees treated previously with tau-fluvalinate. The observed synergism may result from competition between miticides for access to detoxicative P450s. These results suggest that honey bee mortality may occur with the application of otherwise sublethal doses of miticide when tau-fluvalinate and coumaphos are simultaneously present in the hive.
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy (2018)

Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in multiple cancers, yet not all patients respond. We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell-inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. TMB and GEP were independently predictive of response and demonstrated low correlation, suggesting that they capture distinct features of neoantigenicity and T cell activation. Analysis of The Cancer Genome Atlas database showed TMB and GEP to have a low correlation, and analysis by joint stratification revealed biomarker-defined patterns of targetable-resistance biology. These biomarkers may have utility in clinical trial design by guiding rational selection of anti-PD-1 monotherapy and combination immunotherapy regimens.
DELAYED ELEVATION OF SOLUBLE TUMOR NECROSIS FACTOR RECEPTORS P75 AND P55 IN CEREBROSPINAL FLUID AND PLASMA AFTER TRAUMATIC BRAIN INJURY (2006)

Recent studies have reported a significant inflammatory reaction in the brain and the systemic circulation after traumatic brain injury (TBI). Although there is growing knowledge and understanding of the mechanisms and mediators involved in the proinflammatory reaction, little is known about the anti-inflammatory mediators in the brain. As tumor necrosis factor alpha (TNF-alpha) plays a detrimental role in the initiation and promotion of the proinflammatory reactions after TBI, the endogenous scavenger system, represented by the soluble TNF receptors (sTNFRs) p55 and p75, seems to have an important anti-inflammatory capacity by binding to circulating TNF-alpha. To evaluate this potentially anti-inflammatory response to trauma, we analyzed sTNFR p55 and p75 in paired plasma/cerebrospinal fluid (CSF) samples of 29 patients who encountered TBI. Values were compared with reference values obtained from healthy volunteers (n = 91). Patients with TBI showed significantly (P < 0.001) elevated sTNFR p55 and p75 values starting from day 2 and lasting until day 10 if compared with reference values. In contrast to the early increased plasma values p55 and p75 showed slowly increasing CSF values starting on day 4 and 3, respectively. Significantly (P < 0.001) increased CSF values of p 55 were determined on days 4 to 6 and day 9. p75 showed significantly (P < 0.001) elevated values if compared with control values on days 7 and 9. The sTNFR p55 and p75 show a distinct and long-lasting elevation in plasma of patients after TBI. In contrast, CSF values display a delayed and less intense elevation of both receptors in patients with TBI. These findings are suggestive of an imbalance of the proinflammatory and anti-inflammatory reactions of the central nervous system after trauma, with an emphasis on the proinflammatory mechanisms and a slow increase of potentially anti-inflammatory mediators such as the soluble TNFRs after TBI.
Comparative immunogenicity of hepatitis B virus core and E antigens. (1988)

The nucleocapsid (hepatitis B core Ag (HBcAg] of the hepatitis B virus is a particulate Ag composed of a single polypeptide (p21). Although a non-particulate form of HBcAg designated hepatitis B e Ag (HBeAg) shares significant amino acid identity, the immune responses to these Ag appear to be regulated independently. This report describes the use of recombinant HBcAg and HBeAg to examine and compare murine T cell and B cell recognition of these related Ag. The HBcAg preparation was stable at pH 7.2 and 9.6 and expressed HBc antigenicity. However, the antigenicity of the HBeAg preparation was pH dependent. At pH 9.6 the HBeAg preparation was non-particulate and expressed HBe antigenicity exclusively; however, at pH 7.2 it was particulate and expressed both HBc and HBe antigenicities. Although this "hybrid" particle most likely does not exist naturally, it is a unique research reagent to investigate the interrelationship between HBcAg and HBeAg. HBcAg was significantly more immunogenic in terms of in vivo antibody production as compared to either the non-particulate or particulate forms of HBeAg. Nevertheless, in most murine strains HBcAg and HBeAg were equivalently immunogenic and crossreactive at the level of T cell activation. The disparity between anti-HBc and anti-HBe antibody production is best explained by the observation that HBcAg can function as a T cell-independent Ag whereas HBeAg is T cell dependent even when present within the same particulate structure as HBcAg. Furthermore, HBcAg was shown to function efficiently as an immunologic carrier moiety for the DNP hapten in athymic as well as euthymic mice in contrast to conventional carrier proteins. These results have implications relevant to the human immune responses to HBcAg and HBeAg during infection, and to vaccine development.
Modulation of Pain in Osteoarthritis (2008)

(1) The roles of NO in nociception are dual and complex. (2) NO via cNOS, produced transiently in small amounts, can bring dramatic relief to people with painful OA.
Protective effects of anti‐C5a peptide antibodies in experimental sepsis (2001)

We evaluated antibodies to different peptide regions of rat C5a in the sepsis model of cecal ligation and puncture (CLP) for their protective effects in rats. Rabbit polyclonal antibodies were developed to the following peptide regions of rat C5a: amino-terminal region (A), residues 1-16; middle region (M), residues 17-36; and the carboxyl-terminal region (C), residues 58-77. With rat neutrophils, the chemotactic activity of rat C5a was significantly inhibited by antibodies with the following rank order: anti-C > anti-M >> anti-A. In vivo, antibodies to the M and C (but not A) regions of C5a were protective in experimental sepsis, as determined by survival over a 10-day period, in a dose-dependent manner. The relative protective efficacies of anti-C5a preparations (in descending order of efficacy) were anti-C > anti-M >> anti-A. In CLP rats, a delay in infusion of antibodies, which were injected at 6 or 12 h after CLP, still resulted in significant improvement in survival rates. These in vivo and in vitro data suggest that there are optimal targets on C5a for blockade during sepsis and that delayed infusion of anti-C5a antibody until after onset of clinical evidence of sepsis still provides protective effects.
A MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY (1977)

The oestrogenic and antioestrogenic properties of tamoxifen and its monohydroxylated (monohydroxytamoxifen) and dihydroxylated (dihydroxytamoxifen) metabolites have been investigated in the immature rat. Whether administered orally or subcutaneously, monohydroxytamoxifen was more active than tamoxifen as an antioestrogen. Dihydroxytamoxifen was less active than tamoxifen as an antioestrogen, but this derivative alone was unable to induce a uterotrophic response. Both metabolites of tamoxifen were potent inhibitors of the binding of [3H]oestradiol to oestrogen receptors in vitro. It is possible that the metabolites play a supportive role in the antioestrogenic activity of tamoxifen. The potent activity of monohydroxytamoxifen in vivo and in vitro suggests that this compound could be an important new tool for the subcellular investigation of oestrogenic and antioestrogenic events.
Repairing the Damaged Spinal Cord and Brain with Nanomedicine (2008)

Polyethylene glycol (PEG)-coated silica colloids circulating in the bloodstream target only injured tissues, particularly a spinal-cord injury (see picture). The PEG coating both seals and induces repair of damaged cells, leading to a recovery of physiological function. These PEG-coated colloids have been characterized, tested in ex vivo spinal cord and in living adult Guinea pig spinal-cord injury.