gebhart/patrepeval huggingface dataset:
Fields virology. 2nd edition. Vols 1 and 2. (1990)

A combination of dietary guild analysis and nitrogen (δ(15) N) and carbon (δ(13) C) stable-isotope analysis was used to assess the trophic structure of the fish community in Rhode Island and Block Island Sounds, an area off southern New England identified for offshore wind energy development. In the autumn of 2009, 2010 and 2011, stomach and tissue samples were taken from 20 fish and invertebrate species for analysis of diet composition and δ(15) N and δ(13) C signatures. The food chain in Rhode Island and Block Island Sounds comprises approximately four trophic levels within which the fish community is divided into distinct dietary guilds, including planktivores, benthivores, crustacivores and piscivores. Within these guilds, inter-species isotopic and dietary overlap is high, suggesting that resource partitioning or competitive interactions play a major role in structuring the fish community. Carbon isotopes indicate that most fishes are supported by pelagic phytoplankton, although there is evidence that benthic production also plays a role, particularly for obligate benthivores such as skates Leucoraja spp. This type of analysis is useful for developing an ecosystem-based approach to management, as it identifies species that act as direct links to basal resources as well as species groups that share trophic roles.
Transrectal high‐intensity focused ultrasound for the treatment of localized prostate cancer: Eight‐year experience (2009)

High-intensity focused ultrasound therapy appears to be minimally invasive, efficacious and safe for patients with localized prostate cancer, particularly those with low- and intermediate-risk cancer.
Opioid Antagonists for Pharmacological Treatment of Alcohol Dependence – A Critical Review (2008)

Alcohol dependence is a widespread psychiatric disorder. While relapse prevention therapy in alcoholism was exclusively dominated by social and psychological treatments for many years, in the last decades the benefits of pharmacological agents for the rehabilitation treatment in alcoholism have become increasingly evident. Naltrexone, an opiate receptor antagonist, blocks the pleasant and reinforcing effects of alcohol by preventing the stimulation of opioid receptors and the reduction of dopamine release in the ventral tegmental area (VTA). Clinical evidence about the effectiveness of the substance is not always consistent, but meta-analyses confirm naltrexone's effect on the risk of heavy drinking. Evidence about the abstinence-maintaining effects of the substance comes from a relatively small database and needs further investigation. The evaluation of differential effects of naltrexone depending on biological or psychological profiles, which could further enhance the effectiveness of treatments for alcohol dependence, remains a challenge. Nalmefene, another opioid antagonist, as well as naltrexone depot, a sustained release formulation of naltrexone, are further promising strategies for the treatment of alcohol dependence. The review at hand gives on overview of the current evidence on opioid antagonists for the treatment of alcohol dependence regarding the possible mechanism of action, the substances' safety profiles and their effectiveness. The corresponding evidence is critically reviewed taking into consideration the influence of the study design on the magnitude and consistency of effect sizes as well the impact of patient characteristics on the response to the treatment with opioid antagonists. Future studies on the role of different subtypes of alcoholics according to their genetic or psychological profile to explain or even predict the effects of opioid antagonists in the treatment of alcohol dependence are needed.
Synthesis of single-walled carbon nanotubes by induction thermal plasma (2009)

The production of high quality single-walled carbon nanotubes (SWCNTs) on a bulk scale has been an issue of considerable interest. Recently, it has been demonstrated that high quality SWCNTs can be continuously synthesized on large scale by using induction thermal plasma technology. In this process, the high energy density of the thermal plasma is employed to generate dense vapor-phase precursors for the synthesis of SWCNTs. With the current reactor system, a carbon soot product which contains approximately 40 wt% of SWCNTs can be continuously synthesized at the high production rate of ∼100 g/h. In this article, our recent research efforts to achieve major advances in this technology are presented. Firstly, the processing parameters involved are examined systematically in order to evaluate their individual influences on the SWCNT synthesis. Based on these results, the appropriate operating conditions of the induction thermal plasma process for an effective synthesis of SWCNTs are discussed. A characterization study has also been performed on the SWCNTs produced under the optimum processing conditions. Finally, a mathematical model of the process currently under development is described. The model will help us to better understand the synthesis of SWCNTs in the induction plasma process.
High humidity suppresses ssi4‐mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression (2004)

The Arabidopsis ssi4 mutant, which exhibits spontaneous lesion formation, constitutive expression of pathogenesis-related (PR) genes and enhanced resistance to virulent bacterial and oomycete pathogens, contains a gain-of-function mutation in a TIR-NBS-LRR type R gene. Epistatic analyses revealed that both PR gene expression and disease resistance are activated via a salicylic acid (SA)- and EDS1-dependent, but NPR1- and NDR1-independent signaling pathway. In this study, we demonstrate that in moderate relative humidity (RH; 60%), the ssi4 mutant accumulates H(2)O(2) and SA prior to lesion formation and displays constitutive activation of the MAP kinases AtMPK6 and AtMPK3. It also constitutively expresses a variety of defense-associated genes, including those encoding the WRKY transcription factors AtWRKY29 and AtWRKY6, the MAP kinases AtMPK6 and AtMPK3, the powdery mildew R proteins RPW8.1 and RPW8.2, EDS1 and PR proteins. All of these ssi4-induced responses, as well as the chlorotic, stunted morphology and enhanced disease resistance phenotype, are suppressed by high RH (95%) growth conditions. Thus, a humidity sensitive factor (HSF) appears to function at an early point in the ssi4 signaling pathway. All ssi4 phenotypes, except for MAP kinase activation, also were suppressed by the eds1-1 mutation. Thus, ssi4-induced MAP kinase activation occurs downstream of the HSF but either upstream of EDS1 or on a separate branch of the ssi4 signaling pathway. SA is a critical signaling component in ssi4-mediated defense responses. However, exogenously supplied SA failed to restore lesion formation in high RH-grown ssi4 plants, although it induced defense gene expression. Thus, additional signals also are involved.
Transgenic Mouse Methods and Protocols (2010)

The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in
Toward Greener Nanosynthesis (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward Greener NanosynthesisJennifer A. Dahl, Bettye L. S. Maddux, and James E. HutchisonView Author Information Department of Chemistry and Materials Science Institute, University of Oregon, 1253 University of Oregon, Eugene, Oregon 97403 Cite this: Chem. Rev. 2007, 107, 6, 2228–2269Publication Date (Web):June 13, 2007Publication History Received15 February 2007Published online13 June 2007Published inissue 1 June 2007https://pubs.acs.org/doi/10.1021/cr050943khttps://doi.org/10.1021/cr050943kresearch-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views13943Altmetric-Citations1099LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ligands,Metal nanoparticles,Nanomaterials,Nanoparticles,Solvents Get e-Alerts
Efficacy of API 20C and ID 32C Systems for Identification of Common and Rare Clinical Yeast Isolates (1998)

The abilities of the API 20C and ID 32C yeast identification systems to identify 123 common and 120 rare clinical yeast isolates were compared. API 20C facilitated correct identification of 97% common and 88% rare isolates while ID 32C facilitated correct identification of 92% common and 85% rare isolates.
Less is more: zero-shot learning from online textual documents with noise suppression (2016)

Classifying a visual concept merely from its associated online textual source, such as a Wikipedia article, is an attractive research topic in zero-shot learning because it alleviates the burden of manually collecting semantic attributes. Several recent works have pursued this approach by exploring various ways of connecting the visual and text domains. This paper revisits this idea by stepping further to consider one important factor: the textual representation is usually too noisy for the zero-shot learning application. This consideration motivates us to design a simple-but-effective zero-shot learning method capable of suppressing noise in the text. More specifically, we propose an $l_{2,1}$-norm based objective function which can simultaneously suppress the noisy signal in the text and learn a function to match the text document and visual features. We also develop an optimization algorithm to efficiently solve the resulting problem. By conducting experiments on two large datasets, we demonstrate that the proposed method significantly outperforms the competing methods which rely on online information sources but without explicit noise suppression. We further make an in-depth analysis of the proposed method and provide insight as to what kind of information in documents is useful for zero-shot learning.
Catalytic conversion of benzene to phenol (2016)

Phenol is very useful intermediate in the manufacture of petrochemicals, drugs, agrochemicals, and plastics. Commercially, phenol is produced by a three-step, high-energy consumption process known as the cumene process. The conversion of a chemical to a value-added product is always economically desirable. More than 90% of phenol consumption in the world is manufactured by the multistep cumene process, in which acetone is coproduced in 1: 1 molar ratio with respect to phenol. However, the drawbacks of the three-step cumene process have spurred the development of more economical routes to decrease energy consumption, avoid the formation of explosive cumene hydroperoxide, and increase the yield. The objective of this article is to highlight benzene-to-phenol conversion technologies with emphasis on direct conversion methods. Gas phase and liquid phase reactions are the two main routes for direct oxidation of benzene to phenol. Indirect methods, such as the cumene process, and direct methods of benzene-to-phenol conversion are discussed in detail. Also discussed is the single-step reaction of benzene to phenol using oxidants such as O2, N2O, and H2O2. Catalytic conversion of benzene to value-added phenol using a chemically converted graphene-based catalyst, a cost-effective carbon material, is discussed.
The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review (2007)

Non-compliance with cardiovascular and antidiabetic medication is a significant problem, with around 30% of days 'on therapy' not covered by medication and only 59% of patients taking medication for more than 80% of their days 'on therapy' in a year. Good compliance has a positive effect on clinical outcome, suggesting that the management of CVD may be improved by improving patient compliance.
Functional reconstitution of the human interleukin-3 receptor (1992)

The high-affinity receptors for human interleukin-3 (IL-3), GM-CSF, and IL-5 are composed of alpha and beta subunits. The alpha subunits are primary ligand binding proteins specific for each ligand, whereas the three human receptors share a common beta subunit (beta c). In contrast to humans mice have two closely related genes, AIC2A and AIC2B, which are homologous to human beta c. The AIC2A gene encodes a low-affinity murine IL-3 binding protein, and the AIC2B protein is the beta subunit shared between murine GM-CSF receptors (mGMR) and IL-5 receptors (mIL- 5R). To examine the function of these receptor components, we established various stable transfectants of murine IL-2-dependent CTLL- 2 cells. CTLL-2 transfectants expressing both the alpha and beta subunits of the human IL-3 receptor (hIL-3R) proliferated in response to physiologic concentrations of hIL-3. Coexpression of hIL-3R alpha with AIC2B but not with AIC2A in CTLL-2 cells conferred a growth response to hIL-3. Although CTLL-2 transfectants expressing hIL-3R alpha alone did not proliferate in the presence of hIL-3, hIL-3- responsive sublines were repeatedly isolated. These sublines expressed endogenous AIC2B but not AIC2A. These results indicate that human beta c is essential for hIL-3 signaling and that AIC2B is a murine equivalent of human beta c. We also showed that hIL-3 and hGM-CSF induced tyrosine phosphorylation of several proteins in CTLL transfectants, similar to those observed in human factor-dependent TF-1 cells stimulated with hIL-3 and hGM-CSF.
Low-voltage-driven and highly-diffractive holographic polymer dispersed liquid crystals with spherical morphology (2017)

Low-voltage driven and highly diffractive HPDLC gratings were formed by dialing the phase separated microphology through simple LC mixing.
Patterned Polymer Multilayers as Etch Resists (1999)

This paper describes the synthesis and characterization of patterned polymer multilayers on self-assembled monolayers (SAMs) and the use of these structures as etch resists for gold. The procedure used to build polymer multilayers consisted of five steps: (i) A polar thiolHS(CH2)15COOHwas patterned on gold or silver films by microcontact printing (μCP) with a poly(dimethylsiloxane) (PDMS) stamp. (ii) The patterned surface was placed in a solution containing CH3(CH2)15SH to form a nonpolar, methyl-terminated SAM on the remaining bare metal surface. (iii) The regions of the SAM patterned with CO2H groups were activated for further chemical reaction by conversion into interchain anhydride groups. (iv) The activated substrate was allowed to react with poly(ethylene imine) (PEI, branched chain, Mw 750 000). (v) A second polymer layer was attached to the PEI layer by allowing the amine-terminated surface to react with poly(octadecene-alt-maleic anhydride) (POMA, Mw 30 000) or poly(styrene-alt-maleic anhydride) (PSMA, Mw 350 000). This procedure (alternating reaction with PEI and POMA/PSMA) was repeated up to five times to increase the number of layers and the thickness of the patterned structure. The polymer multilayers were characterized using atomic force microscopy (AFM), ellipsometry, and polarized infrared external reflectance spectroscopy (PIERS). The stability of the films was demonstrated by using the patterned polymer multilayers as etch resists and by measuring their breakdown voltages.
Reversible Alterations in Platelet Morphology Produced by Anticoagulants and by Cold (1954)

Abstract The morphology of the blood platelets has been studied under various conditions by fixing the platelets, observing them under the phase microscope, and classifying them according to shape. It has been found that most platelets maintain their native disc form in citrated or oxalated blood kept at 37 C. In EDTA blood they are converted to spheres. The platelets in citrated and oxalated blood are sphered by 10 minutes' exposure to 0 C., but many of them resume the disc form when body temperature is restored. Washed platelets prepared from EDTA blood are spherical even when resuspended in saline or in gelatin solution and incubated at 37 C. for 45 minutes. When resuspended in oxalated plasma or in albumin or gum acacia solutions, however, many of them revert to the disc shape. A smaller proportion of unwashed platelets, separated from EDTA blood by centrifugation and resuspended in oxalated plasma also resume their disc form after incubation.
Mechanochemical Synthesis: A Tool to Tune Cation Site Disorder and Ionic Transport Properties of Li3MCl6(M = Y, Er) Superionic Conductors (2020)

The lithium-conducting, rare-earth halides, Li₃MX₆ (M = Y, Er; X = Cl, Br), have garnered significantly rising interest recently, as they have been reported to have oxidative stability and high ionic conductivities. However, while a multitude of materials exhibit a superionic conductivity close to 1 mS cm⁻¹, the exact design strategies to further improve the ionic transport properties have not been established yet. Here, the influence of the employed synthesis method of mechanochemical milling, compared to subsequent crystallization routines as well as classic solid-state syntheses on the structure and resulting transport behavior of Li₃ErCl₆ and Li₃YCl₆ are explored. Using a combination of X-ray diffraction, pair distribution function analysis, density functional theory, and impedance spectroscopy, insights into the average and local structural features that influence the underlying transport are provided. The existence of a cation defect within the structure in which Er/Y are disordered to a new position strongly benefits the transport properties. A synthetically tuned, increasing degree of this disordering leads to a decreasing activation energy and increasing ionic conductivity. This work sheds light on the possible synthesis strategies and helps to systematically understand and further improve the properties of this class of materials.
Heterojunction bipolar transistors with emitter barrier lowered by /spl delta/-doping (1994)

An npn heterojunction bipolar transistor with a Si-/spl delta/-doped layer at the emitter-base hetero-interface is demonstrated. The Si /spl delta/-doped layer reduces the potential spike at the emitter junction. This design reserves the abruptness of the heterojunction, reduces electron barrier and increases the hole barrier simultaneously. Experimental results show that the HBT's turn-on characteristics are greatly improved while the current gain remains high. The offset voltages as low as 44 mV have been obtained. Very high current gains at very low collector current densities are obtained.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography (2004)

From calibrated, weakly scattering tissue phantoms (2-6 mm-1), we extract the attenuation coefficient with an accuracy of 0.8 mm-1 from OCT data in the clinically relevant 'fixed focus' geometry. The data are analyzed using a single scattering model and a recently developed description of the confocal point spread function (PSF). We verify the validity of the single scattering model by a quantitative comparison with a multiple scattering model, and validate the use of the PSF on the calibrated samples. Implementation of this model for existing OCT systems will be straightforward. Localized quantitative measurement of the attenuation coefficient of different tissues can significantly improve the clinical value of OCT.
Large, deep layer pyramid-pyramid single axon EPSPs in slices of rat motor cortex display paired pulse and frequency-dependent depression, mediated presynaptically and self-facilitation, mediated postsynaptically (1993)

1. In slices of rat sensorimotor cortex, dual intracellular recordings were obtained from 1,952 pairs of deep layer pyramidal neurons. Where action potentials in one neurone elicited excitatory postsynaptic potentials (EPSPs, n = 56) in the other, responses to different presynaptic firing rates and patterns and at different postsynaptic membrane potentials were recorded and on some occasions both neurons were filled with biocytin. 2. Slices were fixed, sectioned again at 60 microns, and incubated with Avidin horseradish peroxidase (HRP), which was then visualized using the 3,3'-diaminobenzidine tetrahydrochloride (DAB) method. All neurones reported here that were identified histologically were pyramidal cells with their somata in the deep layers (V and VI). 3. One in 70 of the tests performed revealed a synaptic connection, 25 of which were studied in detail. Mean EPSP amplitude was 1.67 +/- 1.66 (SD) mV, with some single sweep events as large as 9 mV. For some of the smaller EPSPs the amplitude distributions contained a clear peak around 0 mV, the coefficient of variation (CV) was large, and paired pulse facilitation was apparent. EPSPs with large average amplitudes displayed no apparent failures of transmission, EPSP amplitudes were fairly evenly distributed around the mean, CVs were small, and paired pulse depression was apparent in 2.5 mM extracellular Ca2+. When single sweeps were selected according to the size of the first EPSP, large second EPSPs were found to follow small first EPSPs and small second EPSPs to follow large first EPSPs. Paired pulse effects appeared, in the majority of tests, to be due to a change in presynaptic release probability. 4. Two EPSPs were recorded in three different extracellular Ca2+ concentrations. In 1 mM Ca2+, the first EPSP of a short interval pair was small and paired pulse facilitation was apparent. In 5 mM Ca2+, first EPSPs were between 2.5 and 4 times larger than in 1 mM Ca2+ and paired pulse depression was apparent. In all Ca2+ concentrations however, averaged third and fourth EPSPs of brief bursts were of similar amplitudes and smaller than second EPSPs. If presynaptic inhibition does contribute to paired pulse effects here, it is not overcome by a combination of raised extracellular Ca2+ and repetitive presynaptic firing. 5. These EPSPs displayed a wide range of time courses. The mean 10-90% rise time was 2.49 +/- 1.08 ms, the mean width at half amplitude was 15.39 +/- 5.42 ms (n = 22), and the mean EPSP latency was 1.59 +/- 0.68 ms (n = 18). (ABSTRACT TRUNCATED AT 400 WORDS)