gebhart/patrepeval huggingface dataset:
Microwave-Mediated Synthesis of Anticarcinogenic Isoflavones from Soybeans (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrowave-Mediated Synthesis of Anticarcinogenic Isoflavones from SoybeansYu-Chen Chang, Muraleedharan G. Nair, Ross C. Santell, and William G. HelferichCite this: J. Agric. Food Chem. 1994, 42, 9, 1869–1871Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jf00045a007https://doi.org/10.1021/jf00045a007research-articleACS PublicationsRequest reuse permissionsArticle Views898Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Air-stable, storable, and highly efficient chiral zirconium catalysts for enantioselective Mannich-type, aza Diels–Alder, aldol, and hetero Diels–Alder reactions (2004)

For the synthesis of optically active compounds, chiral catalysts have attracted much attention because large quantities of optically active molecules can be prepared from a small amount of a chiral source. However, many chiral catalysts are often unstable in air (oxygen) and/or in the presence of water. This is especially the case in chiral Lewis acid catalysis, because most Lewis acids are air- and moisture-sensitive. Therefore, many catalysts are prepared in situ in an appropriate solvent just before use, and they cannot be stored for extended periods. We have developed air-stable, storable, and highly efficient chiral zirconium Lewis acids. The catalysts promoted asymmetric Mannich-type, aza Diels-Alder, aldol, and hetero Diels-Alder reactions efficiently with high enantioselectivities. A key to stabilizing the catalysts is an appropriate combination of chiral zirconium Lewis acids with molecular sieves, and the zirconium-molecular sieves-combined catalysts can be stored for extended periods in air at room temperature without loss of activity. Moreover, it has been demonstrated that the catalysts can be recovered and reused.
Evidence for a New Plasma Thromboplastin Factor I. Case Report, Coagulation Studies and Physicochemical Properties (1965)

Abstract Studies of defective plasma thromboplastin formation in four siblings indicated a defect which was different from any of the known coagulation factor deficiency states. Although none of the children had any history of hemorrhagic tendencies, a prolonged whole blood clotting time in an 11-year-old girl led to the findings of a markedly prolonged partial thromboplastin time (PTT), abnormal thromboplastin generation test (TGT), and a normal prothrombin time in the patient and in three of her ten siblings. The abnormal PTT and TGT were corrected by aluminum hydroxide adsorbed fresh plasma and by serum. Using the kaolin-PTT system, equal mixtures of plasma from the patients and normal plasma produced a normal time. In addition, plasmas deficient in plasma thromboplastin antecedent (PTA), Hageman factor (HF), antihemophilic factor (AHF), or plasma thromboplastin component (PTC) corrected the abnormality. Physical and chemical properties of plasma correcting the defect in vitro indicated that the defect is closely related to that found in PTA and HF deficient plasma.
Digital signal processing handbook : CRCnetBASE 1999 (1999)

* Telecommunications * Computer engineering * Acoustics * Seismic data analysis * DSP software and hardware * Image and video processing * Remote sensing * Multimedia applications * Medical technology * Radar and sonar applications
Use of a Long-Lifetime Re(I) Complex in Fluorescence Polarization Immunoassays of High-Molecular-Weight Analytes (1998)

We describe a new class of fluorescence polarization immunoassays based on the luminescence from a Re(I) metal-ligand complex. Re(I) complexes are extremely photostable and possess useful photophysical properties including long lifetimes, high quantum yields, and high emission polarization in the absence of rotational diffusion. In the present study, a conjugatable, highly luminescent Re(I) metal-ligand complex, [Re(bcp)(CO)3(4-COOHPy)](ClO4), where bcp is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline and 4-COOHPy is isonicotinic acid, has been evaluated for use in fluorescence polarization immunoassays (FPIs) with high-molecular-weight antigens. This Re(I) complex (Re) displays highly polarized emission (with a maximum anisotropy near 0.3) in the absence of rotational diffusion and a long average lifetime (2.7 microseconds) when bound to human serum albumin (HSA) in oxygenated aqueous solution. The emission polarization of the Re-HSA conjugate is sensitive to the binding of anti-HSA, resulting in a significant increase in anisotropy. The labeled HSA was also used in a competition immunoassay where unlabeled HSA was also used as an antigen. These experimental results, combined with theoretical predictions, demonstrate the potential of this Re(I) metal-ligand complex as a luminescence probe in FPIs of high-molecular-weight analytes (10(5)-10(8) Da).
Angiotensin-Converting Enzyme 2 — A New Cardiac Regulator (2002)

The renin–angiotensin system is a master regulator of human physiology. It controls blood pressure and fluid and electrolyte balance through coordinated effects on the heart, blood vessels, and kidneys. In the classic pathway of the renin–angiotensin system, renin is secreted from the juxtaglomerular apparatus of the kidney and acts on the circulating precursor angiotensinogen to generate angiotensin I (Figure 1). Angiotensin I has little effect on blood pressure and is converted in the lungs by angiotensin-converting enzyme (ACE) to angiotensin II. A potent vasopressor, angiotensin II acts on the heart and the kidneys by binding to the G protein–coupled receptors . . .
Identification of phosphatidylinositol 4-kinase type II β as HLA class II-restricted target in graft versus leukemia reactivity (2008)

Patients with hematological malignancies can be successfully treated with HLA-matched T cell-depleted allogeneic stem cell transplantation (alloSCT) and subsequent donor lymphocyte infusions (DLIs). The efficacy of DLI is mediated by donor T cells recognizing minor histocompatibility antigens (mHags) on malignant recipient cells. Because HLA class II molecules are predominantly expressed on hematopoietic cells, mHag-specific CD4(+) T cells may selectively mediate graft versus leukemia (GvL) reactivity without graft versus host disease (GvHD). In this study, we used a recombinant bacteria cDNA library for the identification of the first autosomal HLA class II (HLA-DQB1*0603)-restricted mHag LB-PI4K2B-1S encoded by the broadly expressed phosphatidylinositol 4-kinase type II beta gene. A polyclonal CD4(+) T cell response against LB-PI4K2B-1S was demonstrated in a patient with relapsed chronic myeloid leukemia (CML) who responded to DLI after HLA-matched alloSCT. LB-PI4K2B-1S-specific CD4(+) T cells recognized and lysed the CD34(+) CML cells of the patient and other leukemic cells as well as high HLA-DQ-expressing normal hematopoietic cells. HLA-DQ expression on normal cells of nonhematopoietic origin was moderately up-regulated by IFN-gamma and not sufficient for T cell recognition. We hypothesize that LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells.
GH‐secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23–24 (2003)

We reconfirm the important role of activating mutations of GNAS1 in GH-secreting adenomas, and conclude that PRKAR1A does not play a significant role in the tumourigenesis.
Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector. Explanation for variations in paraquat resistance. (1990)

Transfection of a human pSV2 (copper-zinc) superoxide dismutase expression vector into murine fibroblasts resulted in stable clones producing increased amounts of copper-zinc superoxide dismutase. A marked increase in endogenous glutathione peroxidase activity (up to 285%) and a smaller increase in glutathione transferase activity (up to 16%) also occurred. Manganese superoxide dismutase activity was decreased in all clones, whereas catalase and NADPH reductase activities were not affected. Alterations in glutathione peroxidase and manganese superoxide dismutase activities correlated with increases in copper-zinc superoxide dismutase activity. Whereas all clones were resistant to paraquat, a direct correlation between copper-zinc superoxide dismutase activity and resistance to paraquat did not exist. In agreement with previous reports clones expressing the highest copper-zinc superoxide dismutase activity did not display the highest resistance to paraquat. However, there was a direct correlation between the increase in glutathione peroxidase activity and paraquat resistance (p less than 0.002).
Electronic and optoelectronic properties of semiconductor structures (2003)

Jasprit Singh presents the underlying physics behind devices that drive today's technologies, utilizing carefully chosen solved examples to convey important concepts. Real-world applications are highlighted throughout the book, stressing the links between physical principles and actual devices. The volume provides engineering and physics students and professionals with complete coverage of key modern semiconductor concepts. A solutions manual and set of viewgraphs for use in lectures is available for instructors, from solutions@cambridge.org.
The Influence of Vagus Nerve Stimulation on Memory (2006)

The means by which VNS improves retention is probably related to the increased activity in the nucleus of the tractus solitarius and the locus coeruleus-central adrenergic system that activates the amygdala and increases long-term potentiation in the hippocampus.
P4.059 HIV Prevalence and Behavioural Risk Factors Among Male Sex Workers (Money Boys) in an Urban City of Southwest China (2013)

<h3>Background</h3> Male sex workers (MSW) in China, known as “money boys”, have been identified as a bridging population for transmission of HIV/STIs between communities of men who have sex with men (MSM) and the general population. <h3>Method</h3> Based on geographic mapping and enumeration results in Chengdu, a sample of sex work venues (n = 23) was selected and profiled to understand the network operation and forming of the MSW industry in Chengdu. To reduce the social desirability bias of face-to-face interviews, Polling Booth Survey (PBS) was used to document the risks behaviours of MSWs (n = 130). Data from voluntary counselling/testing (VCT) of MSW (N = 531) and general MSMs (N = 1908) were analysed for HIV prevalence. <h3>Results</h3> On average, MSW provided sexual services to 4–6 clients (mean = 2.4 ± 3.5) per day, with as many as 10 clients (mean = 7.1 ± 5.25 std) in a peak day. All respondents reported 100% condom use during face-to-face interviews. PBS results, however, revealed that only 74% of MSW used condoms every time and 76% in last anal sex. Using condoms with permanent sex partners was lower (44% last month anal sex). 14% of MSW had anal sex 3+ times, and 4% had anal sex 7+ times in one day. VCT data showed a relatively lower HIV prevalence (6%) in MSW (N = 531) compared to the HIV prevalence (10%) in MSM in 2012. 29% of MSWs identified as heterosexual, 20% as bisexual, and 51% as gay. <h3>Conclusion</h3> Male sex work in urban China has grown into a thriving industry. Due to high client volumes, unprotected anal sex, multiple concurrent sexual partners, and participation in sexual networks that span various cities throughout China, MSWs are at a higher risk for HIV/STI transmission. PBS is a more reliable method to examine risky sexual behaviours among high risk populations.
Microfluidic bypass for efficient passive regulation of droplet traffic at a junction (2006)

We propose a simple design for microfabricated junctions that allows an equal and regular distribution of droplets between the two outlets of a T junction. It relies on establishing a connection between the two outlets shortly after the junction to provide short-time memory to the device and induce perfect alternation in the choice of the outlet. We experimentally demonstrate the benefits of this simple passive device by a direct comparison to junctions without bypasses.
Increased Flexibility in Marine Seismic Recording Systems (1988)

A new digital fibre optic streamer and recording system continues the trend towards finer spatial sampling, and more comprehensive and sophisticated electronic and quality control systems. However, at the same time it provides greater flexibility by giving a choice of hydrophone array lengths, and the option to use multiple streamers. Streamer noise analysis led to a revised design, with new materials, giving a very low tow noise level. The system can be configured as 1, 2 or 4 streamers, the multiple streamers giving increased efficiency in 3D data collection. For increased coherent noise attenuation, 3 or 5 streamer groups can be mixed before digitisation, in a weighted overlapping manner. The on-board streamer control system performs many in-water electronic tests on the streamer, while the field computer/recording system has a comprehensive range of seismic quality control and display functions. The system gives the ability to improve the signal-to-noise ratio of the recorded data over a wide variety of conditions.
Titration of the recombinant bovine somatotropin dosage that maximizes the anabolic response in feedlot steers (1990)

The objective of this study was to determine the minimum dosage of recombinant bovine somatotropin (bST) required to elicit maximum depression in plasma urea nitrogen (PUN), an indicator of anabolic activity. Twenty-four steers (389 kg) were blocked by weight into six pens. Six steers were placed on each of the following bST doses: 0, 8, 16 and 32 mg bST/d. Treatments were administered once daily via subcutaneous injections for 21 d. Steers were weighed and jugular blood samples were taken on d 0, 1, 4, 7, 10, 13, 16 and 21 at 1400, approximately 4 h after feeding. Delta PUN (DPUN) was calculated as PUN - d 0 PUN. There was no dose x time interaction (P = .94) in DPUN. Maximum reduction in DPUN with bST occurred by d 7 (P less than .05). Linear (P less than .01) and quadratic (P less than .05) orthogonal contrasts indicated that DPUN depression increased with bST administration, with maximal reduction calculated to occur with 23 mg (59 micrograms/kg) bST/d. There was no further decrease in DPUN with 32 than with 16 mg bST, indicating that the minimum daily dose is at least 16 mg but no more than 23 mg. A similar dose response was observed in daily gain. Results from this study indicate that bST reduced PUN in a dose-dependent manner and that 41 to 64 micrograms/kg body weight maximized the anabolic effect of bST in growing steers.
Low-Dose Amino Asid Supplementation: No Effects on Serum Human Growth Hormone and Insulin in Male Weightlifters (1993)

Using a double-blind, crossover protocol, we studied the possible effects of a 4-day combined L-arginine, L-ornithine, and L-lysine supplementation (each 2 g/day, divided into two daily doses) on 24-hr level of serum human growth hormone (hGH) and insulin in 11 competitive weightlifters, ages 19 to 35 yrs. Three similar daily hGH peaks, seemingly preceded by a decrease in serum insulin concentration, were found during both amino acid and placebo supplementation. Supplementation did not affect the physiological variation of serum hGH concentration (treatment and treatment x time interaction: p = 0.43-0.55). Analogously, serum insulin levels were not higher after amino acid supplementation. Therefore the ergogenic value of low-dose oral amino acid supplementation in increasing hGH or insulin secretion seems questionable.
Acute Systemic Inflammation Impairs Endothelium-Dependent Dilatation in Humans (2000)

S typhi vaccine generates a mild inflammatory reaction associated with temporary but profound dysfunction of the arterial endothelium in both resistance and conduit vessels to both physical and pharmacological dilator stimuli. This finding might explain the association between infection and inflammation and the enhanced risk of an acute cardiovascular event.
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes (2009)

Human leukocyte antigen (HLA) class I molecules present a variety of posttranslationally modified epitopes at the cell surface, although the consequences of such presentation remain largely unclear. Phosphorylation plays a critical cellular role, and deregulation in phosphate metabolism is associated with disease, including autoimmunity and tumor immunity. We have solved the high-resolution structures of 3 HLA A2-restricted phosphopeptides associated with tumor immunity and compared them with the structures of their nonphosphorylated counterparts. Phosphorylation of the epitope was observed to affect the structure and mobility of the bound epitope. In addition, the phosphoamino acid stabilized the HLA peptide complex in an epitope-specific manner and was observed to exhibit discrete flexibility within the antigen-binding cleft. Collectively, our data suggest that phosphorylation generates neoepitopes that represent demanding targets for T-cell receptor ligation. These findings provide insights into the mode of phosphopeptide presentation by HLA as well as providing a platform for the rational design of a generation of posttranslationally modified tumor vaccines.
Design and Generation of Gene‐Targeting Vectors (2011)

This unit provides an overview of the major types of mutant alleles that can be generated by gene targeting in ES cells. It presents the growing public resources of premade gene targeting vectors, modified ES cells, and mutant mice. General guidelines for the design of targeting vectors are followed by protocols for the construction of vectors to generate knockout (KO), conditional KO, and subtle mutant alleles. Curr. Protoc. Mouse Biol. 1:199-211. © 2011 by John Wiley & Sons, Inc.
Overview of interleukin-18: more than an interferon-γ inducing factor (1998)

Initially described in 1989 as interferon-gamma (IFN-gamma) inducing factor (IGIF), interleukin-18 (IL-18) is a novel pro-inflammatory cytokine that is clearly more than an inducer of IFN-gamma. The cytokine possesses several biological properties such as activation of nuclear factor-kappaB (NF-kappaB), Fas ligand expression, the induction of both CC and CXC chemokines, and increased production of competent human immunodeficiency virus. Most activities are due to a receptor complex that recruits the IL-1 receptor-activating kinase (IRAK), leading to translocation of NF-kappaB. This property and others support the concept that IL-18 is related to the IL-1 family. Indeed, one of the IL-18 receptor chains is the IL-1 receptor-related protein, a member of the IL-1R family. In addition, IL-18 is structurally similar to IL-1beta and like IL-1beta is first synthesized as a leaderless precursor requiring the IL-1beta converting enzyme for cleavage into an active molecule. The biology of IL-18 is reviewed in the overview and the implication for a role for this cytokine in disease is presented.
New Iron(III) Phosphate Phases:  Crystal Structure and Electrochemical and Magnetic Properties (2002)

Two new iron(III) phosphates, FePO(4), have been synthesized from the dehydration of hydrothermally prepared monoclinic and orthorhombic hydrated phosphates FePO(4).2H(2)O. The structures of both hydrates were redetermined from single crystal data. On dehydration, a topotactic reaction takes place with only those bonds associated with the water molecules being broken, so that both FePO(4) phases have essentially the same Fe-P backbone frameworks as the corresponding hydrates. They are, respectively, monoclinic FePO(4), space group P2(1)/n, a= 5.480(1) A, b = 7.480(1) A, c= 8.054(1) A, beta = 95.71(1) degrees, and Z = 4; and orthorhombic FePO(4), space group Pbca, a = 9.171(1) A, 9.456(1) A, c = 8.675(1) A, and Z = 8. Both of these phases are thermally unstable relative to the trigonal quartz-like FePO(4). The electrochemical studies find that the orthorhombic iron phosphate is more active than the monoclinic phase, while both are more active than trigonal FePO(4). Both phases approach Curie-Weiss behavior at room temperature, with the monoclinic phase exhibiting stronger antiferromagnetic interactions due to Fe-O-Fe interactions. The electrochemical and magnetic data are consistent with the structures of these two compounds. The properties of these new iron phosphate structures are compared with other iron phosphate phases.