gebhart/patrepeval huggingface dataset:
Transformation of Silver Nanospheres into Nanobelts and Triangular Nanoplates through a Thermal Process (2003)

Silver has been prepared as triangular nanoplates with sharp corners and thin nanobelts by refluxing an aqueous dispersion of spherical colloids of silver with an average diameter of 3.5 nm. The spherical colloids of silver were, in turn, generated by reducing silver nitrate with sodium borohydride in the presence of poly(vinyl pyrrolidone) (PVP) and sodium citrate. Our studies indicate that the light present in an ordinary chemical laboratory was sufficiently strong to transform some spherical nanoparticles into small triangular nanoplates. Refluxing provided the driving force to facilitate the Ostwald ripening process−growth of these plate-like seeds at the expense of spherical nanoparticles. In addition, refluxing might also selectively disrupt the organic layers on the surfaces of the small triangular nanoplates, driving these plates to assemble into thin nanobelts due to the strong dipole−dipole interaction between adjacent plates. These nanostructures of silver with unique planar shapes might find use in areas that include photonics, optoelectronics, and optical sensing.
Catecholamine Dysfunction in Attention-Deficit/Hyperactivity Disorder (2008)

Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disease that affects children, adolescents, and adults. Genetic research has confirmed that there is a large hereditary component to this condition and has helped identify some of the genes associated with it. Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine. Attention-deficit/hyperactivity disorder is believed to be a result of abnormalities in the frontal regions of the brain, particularly the prefrontal cortex and associated subcortical structures and circuits. Underpinning these abnormalities are disturbances of catecholamine neurotransmission. Studies have demonstrated that patients with ADHD have depleted levels of dopamine and norepinephrine thought to be largely the result of dysfunction of their respective transporter systems. The efficacy of stimulant agents confirms that the neurotransmitter abnormalities seen in ADHD are primarily catecholaminergic in origin. This article focuses on the catecholaminergic networks of higher cognitive functions such as attention and focus and of motor functions that may be associated with such networks, reviewing both the physiology of such functions and the pathophysiology of ADHD. Researchers are currently investigating whether other neurotransmitter systems may be partially involved and are investigating whether agents that affect these other systems will prove complementary to currently used treatments.
A survey on data compression in wireless sensor networks (2005)

Wireless sensor networks (WSNs) are resource constraint: limited power supply, bandwidth for communication, processing speed, and memory space. One possible way of achieve maximum utilization of those resource is applying data compression on sensor data. Usually, processing data consumes much less power than transmitting data in wireless medium, so it is effective to apply data compression before transmitting data for reducing total power consumption by a sensor node. However, existing compression algorithms are not applicable for sensor nodes because of their limited resource. Therefore, some of compression algorithms, which have been specifically designed for WSNs, are presented in this paper: coding by ordering, pipelined in-network compression, low-complexity video compression, and distributed compression.
Re-usable thermally reversible crosslinked adhesives from robust polyester and poly(ester urethane) Diels–Alder networks (2020)

Monomer-free and solvent-free thermally reversible crosslinked adhesives from Diels–Alder networks with high performance and capable of multiple re-use.
695. 2-Phenylpurines, their chemical and enzymological reactivity (1963)

F. Bergmann, A. Kalmus, H. Ungar-Waron and H. Kwietny-Govrin, J. Chem. Soc., 1963, 3729 DOI: 10.1039/JR9630003729
ESM-1 Is a Novel Human Endothelial Cell-specific Molecule Expressed in Lung and Regulated by Cytokines (1996)

We here report the identification of a novel human endothelial cell-specific molecule (called ESM-1) cloned from a human umbilical vein endothelial cell (HUVEC) cDNA library. Constitutive ESM-1 gene expression (as demonstrated by Northern blot and reverse transcription-polymerase chain reaction analysis) was found in HUVECs but not in the other human cell lines tested. The cDNA sequence contains an open reading frame of 552 nucleotides and a 1398-nucleotide 3'-untranslated region including several domains involved in mRNA instability and five putative polyadenylation consensus sequences. The deduced 184-amino acid sequence defines a cysteine-rich protein with a functional NH2-terminal hydrophobic signal sequence. Searches in several data bases confirmed the unique identity of this sequence. A rabbit immune serum raised against the 14-kDa COOH-terminal peptide of ESM-1 immunoprecipitated a 20-kDa protein only in ESM-1-transfected COS cells. Immunoblotting and immunoprecipitation of HUVEC lysates revealed a specific 20-kDa band corresponding to ESM-1. In addition, constitutive ESM-1 gene expression was shown to be tissue-restricted to the human lung. Southern blot analysis suggests that a single gene encodes ESM-1. A time-dependent up-regulation of ESM-1 mRNA was seen after addition of tumor necrosis factor alpha (TNFalpha) or interleukin (IL)-1beta but not with IL-4 or interferon gamma (IFNgamma) alone. In addition, when IFNgamma was combined with TNFalpha, IFNgamma inhibited the TNFalpha-induced increase of ESM-1 mRNA level. These data suggest that ESM-1 may have potent implications in the areas of vascular cell biology and human lung physiology.
Bone Marrow Stromal Cells as Targets for Gene Therapy (2002)

The bone marrow (BM) is composed of the non-adherent hematopoietic and adherent stromal cell compartment. This adherent BM stromal cell fraction contains pluripotent mesenchymal stem cells (MSCs) and differentiated mesenchymal BM stromal cells. The MSCs self-renew by proliferation while maintaining their stem-cell phenotype and give rise to the differentiated stromal cells which belong to the osteogenic, chondrogenic, adipogenic, myogenic and fibroblastic lineages. A more primitive adherent stem cell was recently identified, the multipotent adult progenitor cell (MAPC) or mesodermal progenitor cell, which co-purifies with MSCs. These MAPCs differentiate into MSCs, endothelial, epithelial and even hematopoietic cells. BM stroma cells, including the primitive pluripotent MSCs and MAPCs, are attractive targets for cell and gene therapy. The BM stromal cell population and its multipotent stem cells can be engineered to secrete a series of different proteins in vitro and in vivo that could potentially treat a variety of serum protein deficiencies and other genetic or acquired diseases, including bone, cartilage and BM stromal disorders or even cancer.
‘DNA Strider’: a ‘C’ program for the fast analysis of DNA and protein sequences on the Apple Macintosh family of computers (1988)

DNA Strider is a new integrated DNA and Protein sequence analysis program written with the C language for the Macintosh Plus, SE and II computers. It has been designed as an easy to learn and use program as well as a fast and efficient tool for the day-to-day sequence analysis work. The program consists of a multi-window sequence editor and of various DNA and Protein analysis functions. The editor may use 4 different types of sequences (DNA, degenerate DNA, RNA and one-letter coded protein) and can handle simultaneously 6 sequences of any type up to 32.5 kB each. Negative numbering of the bases is allowed for DNA sequences. All classical restriction and translation analysis functions are present and can be performed in any order on any open sequence or part of a sequence. The main feature of the program is that the same analysis function can be repeated several times on different sequences, thus generating multiple windows on the screen. Many graphic capabilities have been incorporated such as graphic restriction map, hydrophobicity profile and the CAI plot- codon adaptation index according to Sharp and Li. The restriction sites search uses a newly designed fast hexamer look-ahead algorithm. Typical runtime for the search of all sites with a library of 130 restriction endonucleases is 1 second per 10,000 bases. The circular graphic restriction map of the pBR322 plasmid can be therefore computed from its sequence and displayed on the Macintosh Plus screen within 2 seconds and its multiline restriction map obtained in a scrolling window within 5 seconds.
Scalable Coordinate Descent Approaches to Parallel Matrix Factorization for Recommender Systems (2012)

Matrix factorization, when the matrix has missing values, has become one of the leading techniques for recommender systems. To handle web-scale datasets with millions of users and billions of ratings, scalability becomes an important issue. Alternating Least Squares (ALS) and Stochastic Gradient Descent (SGD) are two popular approaches to compute matrix factorization. There has been a recent flurry of activity to parallelize these algorithms. However, due to the cubic time complexity in the target rank, ALS is not scalable to large-scale datasets. On the other hand, SGD conducts efficient updates but usually suffers from slow convergence that is sensitive to the parameters. Coordinate descent, a classical optimization approach, has been used for many other large-scale problems, but its application to matrix factorization for recommender systems has not been explored thoroughly. In this paper, we show that coordinate descent based methods have a more efficient update rule compared to ALS, and are faster and have more stable convergence than SGD. We study different update sequences and propose the CCD++ algorithm, which updatesrank-one factors one by one. In addition, CCD++ can be easily parallelized on both multi-core and distributed systems. We empirically show that CCD++ is much faster than ALS and SGD in both settings. As an example, on a synthetic dataset with 2 billion ratings, CCD++ is 4 times faster than both SGD and ALS using a distributed system with 20 machines.
Degenerate Optical Cavities (1969)

An optical cavity is degenerate when an arbitrary ray retraces its own path after a single round trip. The condition for degeneracy is given for ring type cavities incorporating internal lenses, using geometrical optics methods. The simplest linear configurations require a spherical mirror or a corner cube, a thin lens, and a plane mirror. Planar rings with four plane mirrors require at least three thin focusing elements. A nonplanar ring is discussed which requires only two thin lenses. The alignment of degenerate cavities is, in general, as critical as the alignment of plane Fabry-Perot.
Vanilla flavour: production by conventional and biotechnological routes (2000)

This review deals with the Vanilla plant: history; botanical description; chemistry of vanilla beans; curing of vanilla beans; commercial extraction of vanilla flavour; standard specifications and uses of vanilla flavour. The production of vanillin by both chemical and biotechnological methods is described. The biotechnological production of vanilla flavour metabolites by plant tissue/cell culture, microbial biotransformation and molecular approaches is also presented, together with a discussion on economic and safety considerations. © 2000 Society of Chemical Industry
Identification of proteolytically resistant domains of human erythrocyte spectrin. (1980)

Digestion of purified human erthrocyte spectrin with proteolytic enzymes at 0 degrees C results in the production of intermediate-size peptides that resist further cleavage at 0 degrees C. By two-dimensional peptide analysis of these intermediate peptides it has been determined that five unique peptides are produced by tryptic cleavage of the alpha subunit of spectrin (band 1); these have apparent molecular weights of 80,000, 46,000, 46,000, 41,000, and 30,000 and account for 97% of the alpha subunit. Similarly, four unique peptides having apparent molecular weights of 74,000, 65,000, 33,000, and 38,000 account for 90% of the beta subunit (band 2). By examining larger peptide fragments, the linear alignment of the unique peptides along each of the spectrin subunits has been established. These results indicate that spectrin is composed of two nonidentical subunits, each containing multiple proteolytically resistant domains. These domains, which may be largely alpha-helical, seem to be connected by small protease-sensitive segments. The proteolytic resistance of these domains is not influenced by the multimeric state of the spectrin molecule.
ChemInform Abstract: Syntheses and Characterization of (N → B)phenyl(N‐ arylaminodiacetate‐O,O′,N)boranes and N‐Arylaminodiacetic Acids. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cellulite (2000)

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling.
Morphogenesis of the Drosophila fusome and its implications for oocyte specification (1998)

The Drosophila oocyte develops within a cyst of 16 germline cells interconnected by ring canals. Polarized, microtubule-based transport of unknown determinants is required for oocyte formation, but whether polarity is established during or after cyst formation is not clear. We have analyzed how polarity develops in stem cells and dividing cysts by following the growth of the fusome, a vesiculated cytoplasmic organelle. Our studies show that the fusome grows by a regular, polarized process throughout the stem cell and cyst cell cycles. Each polarization cycle begins in mitosis, when the fusome segregates to a single daughter cell of each pair. Following mitosis, a 'plug' of fusomal material forms in each nascent ring canal and gradually fuses with the pre-existing fusome. In stem cells, the ring canal is transient and closes down after the fusome is partitioned through it. In dividing cysts, as the fusome plugs move toward the pre-existing fusome, their associated ring canals also move, changing the geometry of the cyst. At the end of each cycle of cyst growth, the fusome remains asymmetrically distributed within the cyst; one of the two cells with four ring canals retains a bigger piece of fusome than any other cell, including the other cell with four ring canals. Based on these observations, we argue that the oocyte is specified at the first cyst division.
Design and SAR Study of a Novel Class of Nucleotide Analogues as Potent Anti-HCMV Agents (1999)

We have developed a novel class of 2-phosphonate 1,3-dioxolane nucleotide analogues, from which the guanine derivative displayed weak anti-HCMV activity. Further SAR studies led to the identification of both cis and trans guanine derivatives of tetrahydrofuran analogues as potent anti-HCMV agents, both in vitro and in vivo, compared to ganciclovir and HPMPC.
T‐cell markers in tumor‐infiltrating lymphocytes of head and neck cancer (1989)

Fresh suspensions of tumor-infiltrating lymphocytes (TIL) from 16 patients with squamous cell carcinoma of the head and neck (SCCHN) were examined for T-cell markers including CD4 (helper-inducer), CD8 (cytotoxic-suppressor), natural killer (NK) cell, and activation surface markers using monoclonal antibodies and two-color flow cytometry. Two of 8 (25%) patients with a CD4/CD8 ratio of less than 1 developed cervical lymph node metastases; none had extracapsular spread. Six of 8 (75%) patients with a CD4/CD8 ratio of greater than 1 developed cervical metastases; 5 of 6 (83%) exhibited extracapsular spread. An increased CD4/CD8 ratio was attributable to a decrease in CD8+ cells. A CD4/CD8 ratio of greater than 1 may be a useful prognostic indicator of the development of cervical metastases.
Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae (1996)

Pneumococcus has been shown to bind to epithelial cells of the nasopharynx and lung, and to endothelial cells of the peripheral vasculature. To characterize bacterial elements required for attachment to these cell types, a library of genetically altered pneumococci with defects in exported proteins was screened for the loss of attachment to glycoconjugates representative of the nasopharyngeal cell receptor, type II lung cells (LC) and human endothelial cells (EC). A mutant was identified which showed a greater than 70% loss in the ability to attach to all cell types. This mutant also showed decreased adherence to the glycoconjugates containing the terminal sugar residues GalNAcbeta1-3Gal, GalNAcbeta1-4Gal and the carbohydrate GlcNAc, which are proposed components of the pneumococcal receptors specific to the surfaces of LC and EC. Analysis of the locus altered in this mutant revealed a gene, spxB, that encodes a member of the family of bacterial pyruvate oxidases which decarboxylates pyruvate to acetyl phosphate plus H2O2 and CO2. This mutant produced decreased concentrations of H2O2 and failed to grow aerobically in a chemically defined medium, unless supplemented with acetate which presumably restores acetyl phosphate levels by the action of acetate kinase, further suggesting that spxB encodes a pyruvate oxidase. The addition of acetate to the growth medium restored the adherence properties of the mutant indicating a link between the enzyme and the expression of bacterial adhesins. A defect in spxB corresponded to impaired virulence of the mutant in vivo. Compared to the parent strain, an spxB mutant showed reduced virulence in animal models for nasopharyngeal colonization, pneumonia, and sepsis. We propose that a mutation in spxB leads to down-regulation of the multiple adhesive properties of pneumococcus which, in turn, may correlate to diminished virulence in vivo.
Human olfactory receptor responses to odorants (2015)

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.
Links between metabolism and cancer (2012)

Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic glycolysis. Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer cells, which persist in hypoxia that in turn rewires metabolic pathways for cell growth and survival. Excessive caloric intake is associated with an increased risk for cancers, while caloric restriction is protective, perhaps through clearance of mitochondria or mitophagy, thereby reducing oxidative stress. Hence, the links between metabolism and cancer are multifaceted, spanning from the low incidence of cancer in large mammals with low specific metabolic rates to altered cancer cell metabolism resulting from mutated enzymes or cancer genes.
Textbook of AIDS Medicine (1994)

Part 1 Introduction: history. Part 2 Basic science: the virus and its target cells viral genes and their products natural history of HIV-1 disease immunopathogenesis an immunologist's view of HIV infection. Part 3 Epidemiology: epidemiology of HIV infection in industrialized countries epidemiology of AIDS in developing countries public health issues. Part 4 Clinical: clinical spectrum of AIDS special considerations in women special considerations in children HIV and injecting drug users pneumocystis carinii pneumonia toxoplasmosis in the setting of AIDS typical mycobacteria syphillis bacillary angiomatosis tropical diseases in the HIV-infected traveller cryptosporidium and cryptosporidiosis fungi cytomegalovirus infection in patients with HIV infection herpes simplex and varicella zoster virus infections in HIV-infected individuals progressive multifocal leukoence-phalopathy Kaposi's sarcoma and cloacogenic carcinoma associated with AIDS overview of AIDS-related lymphomas - a paradigm of AIDS malignancies AIDS-associated malignant lymphomas AIDS-related lymphomas - clinical aspects ocular sequelae neurologic complications of HIV infection and AIDS cutaneous signs of HIV infection oral manifestations gastro-intestinal manifestations of HIV disease the pancreas in AIDS the peritoneum and mesentery in AIDS liver disease and AIDS renal disease and AIDS cardiac involvement in the patient with AIDS hematologic consequences of HIV infection endocrine abnormalities associated with immunodeficiency virus infection and AIDS the wasting syndrome in AIDS assays for the diagnosis of HIV infections. Part 5 Control and prevention: preventive vaccines therapeutic HIV vaccines immune-based therapies for HIV-1 infection drug discovery biostatistics and clinical study design biochemical pharmacology of nucleoside analogues active against HIV strategies for antiretroviral therapy in adult HIV disease viral resistance to antiretroviral therapy unproven and unconventional therapies psychotherapy and counselling for HIV-positive individuals hospice care and pain management AIDS in health care workers managing occupational exposures to HIV AIDS and ethics diseases associated with other retroviruses human immunodeficience virus type-2 HTLV-1 and HTLV-2.