gebhart/patrepeval huggingface dataset:
A Scaling Roadmap and Performance Evaluation of In-Plane and Perpendicular MTJ Based STT-MRAMs for High-Density Cache Memory (2012)

This paper explores the scalability of in-plane and perpendicular MTJ based STT-MRAMs from 65 nm to 8 nm while taking into consideration realistic variability effects. We focus on the read and write performances of a STT-MRAM based cache rather than the obvious advantages such as the denser bit-cell and zero static power. An accurate MTJ macromodel capturing key MTJ properties was adopted for efficient Monte Carlo simulations. For the simulation of access devices and peripheral circuitries, ITRS projected transistor parameters were utilized and calibrated using the MASTAR tool that has been widely used in industry. 6T SRAM and STT-MRAM arrays were implemented with aggressive assist schemes to mimic industrial memory designs. A constant J <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">C</i> 0·RA/VDD scaling scenario was used which to the first order gives the optimal balance between read and write margins of STT-MRAMs. The thermal stability factor ensuring a 10 year retention time was obtained by adjusting the free layer thickness as well as assuming improvement in the crystalline anisotropy. Our studies based on the proposed scaling methodology show that in-plane STT-MRAM will outperform SRAM from 15 nm node, while its perpendicular counterpart requires further innovations in MTJ material in order to overcome the poor write performance scaling from 22 nm node onwards.
Resistive Computing: Memristors-Enabled Signal Multiplication (2013)

Memristors-based resistive logic computation units are introduced. By controlling the memristors' conditional set operation adaptively to one of the input polarities, bipolar signal multiplication of an input and a stored reference bit is performed by unipolar memristor devices and control switches. The multiplication result is registered in an output nonvolatile memristor so that the computed output can be accessed anytime later on by reading the output memristor's state. A memristive multiplier circuit demonstrates a fast and highly sensitive pattern recognition for highly complex inputs.
Identification and Characterization of TspA, a Major CD4+T-Cell- and B-Cell-StimulatingNeisseria-Specific Antigen (1999)

In search for novel T-cell immunogens involved in protection against invasive meningococcal disease, we screened fractionated proteins of Neisseria meningitidis (strain SD, B:15:P1.16) by using peripheral blood mononuclear cells (PBMCs) and specific T-cell lines obtained from normal individuals and patients convalescing from N. meningitidis infection. Proteins of iron-depleted meningococci produced higher PBMC proliferation indices than proteins of iron-replete organisms, indicating that iron-regulated proteins are T-cell immunogens. Insoluble proteins of the iron-depleted cells, which produced better T-cell stimulation than soluble ones, were fractionated by using sodium dodecyl sulfate-polyacrylamide gels and recovered as five fractions (F1 to F5) corresponding to decreasing molecular weight ranges. The proteins were purified (by elution and precipitation) or electroblotted onto nitrocellulose membranes (dissolved and precipitated) before use in further T-cell proliferation assays. One of the fractions (F1), containing high-molecular-mass proteins (>130 kDa), consistently showed the strongest T-cell proliferation responses in all of the T-cell lines examined. F1 proteins were subdivided into four smaller fractions (F1A to F1D) which were reexamined in T-cell proliferation assays, and F1C induced the strongest responses in patients' T-cell lines. Rabbit polyclonal antibodies to F1C components were used to screen a genomic expression library of N. meningitidis. Two major clones (C1 and C24) of recombinant meningococcal DNA were identified and fully sequenced. Sequence analysis showed that C24 (1,874 bp) consisted of a single open reading frame (ORF), which was included in clone C1 (2, 778 bp). The strong CD4(+) T-cell-stimulating effect of the polypeptide product of this ORF (named TspA) was confirmed, using a patient T-cell line. Immunogenicity for B cells was confirmed by showing that convalescent patients' serum antibodies recognized TspA on Western blots. Additional genetic sequence downstream of C24 was obtained from the meningococcal genomic sequence database (Sanger Centre), enabling the whole gene of 2,761 bp to be reconstructed. The DNA and deduced amino acid sequence data for tspA failed to show significant homology to any known gene, except for a corresponding (uncharacterized) gene in Neisseria gonorrhoeae genome sequences, suggesting that tspA is unique to the genus Neisseria. The DNA and deduced amino acid sequence of the second ORF of clone C1 showed significant homology to gloA, encoding glyoxalase I enzyme, of Salmonella typhimurium and Escherichia coli. Thus, we have identified a novel neisserial protein (TspA) which proved to be a strong CD4(+) T-cell- and B-cell-stimulating immunogen with potential as a possible vaccine candidate.
Characterization of argon fast atom beam source and its application to the fabrication of resonant tunneling diodes (2005)

In this paper, energy distribution spectra of residual ion of the saddle-field argon (Ar) FAR source, and neutralization coefficients were experimentally evaluated for various process parameters by using an analyzer of our own fabricating. Moreover, GaInP/GaAs triple barrier resonant tunneling diodes (TBRTDs) were processed by using the argon FAB etching under appropriate condition and clear NDRs were estimated with high yield.
TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer (2014)

Previous studies have indicated that Her-2 induction causes a strong decrease in thioredoxin interaction protein (TXNIP) in breast cancer cells. However, little is known regarding the prognostic value of TXNIP in clinical breast cancer patients with anti-Her-2 treatment. Using a tissue microarray, we detected TXNIP and p27 expression in breast cancer tissue, as well as corresponding noncancerous tissues. We found that TXNIP expression was associated with better overall survival (OS) in these 150 breast cancer patients and that TXNIP and Her-2 expression status were significantly inversely correlated (r=-0.334, P<0.001). These results were validated in another 101 breast cancer tissue samples (r=-0.422, P<0.001). Moreover, TXNIP expression increased significantly following treatment of the human breast cancer cell lines BT474 and SK-BR-3 with a Her-1/2 inhibitor. Furthermore, TXNIP transfection induced p27 expression and G1 cell cycle arrest and apoptosis. Taken together, our findings suggest that TXNIP plays a critical role in anti-Her-1/Her-2 treatment and may be a potential prognostic marker in breast cancer.
Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas (1985)

Eighty-nine patients with untreated primary neuroblastomas were studied to determine the relation between the number of copies of the N-myc oncogene and survival without disease progression. Genomic amplification (3 to 300 copies) of N-myc was detected in 2 of 16 tumors in Stage II, 13 of 20 in Stage III, and 19 of 40 in Stage IV; in contrast, 8 Stage I and 5 Stage IV-S tumors all had 1 copy of the gene (P less than 0.01). Analysis of progression-free survival in all patients revealed that amplification of N-myc was associated with the worst prognosis (P less than 0.0001); the estimated progression-free survival at 18 months was 70 per cent, 30 per cent, and 5 per cent for patients whose tumors had 1, 3 to 10, or more than 10 N-myc copies, respectively. Of 16 Stage II tumors, 2 with amplification metastasized, whereas only 1 of 14 without amplification did so (P = 0.03). Stage IV tumors with amplification progressed most rapidly: nine months after diagnosis the estimated progression-free survival was 61 per cent, 47 per cent, and 0 per cent in patients whose tumors had 1, 3 to 10, or more than 10 copies, respectively (P less than 0.0001). These results suggest that genomic amplification of N-myc may have a key role in determining the aggressiveness of neuroblastomas.
Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity (2012)

Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse. Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local regulation has been suggested. However, whether dietary lipids are involved in this regulation, as shown in the gut, is unknown. By using a combination of biochemical, immunohistochemical, and behavioral approaches, the present data i) confirm the role of GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long-chain FAs (LCFAs) reinforce the attraction for sucrose in a GLP-1 receptor-dependent manner, iii) suggest an involvement of the LCFA receptor GPR120 expressed in taste buds in this system, and iv) support the existence of a regulation by GLP-1 of the lipid sensing mediated by lingual CD36. Therefore, oro-sensory detection of LCFAs may affect sweet and fatty taste responsiveness by controlling the secretion of lingual GLP-1. This regulatory loop, probably triggered by the LCFA-GPR120 interaction, might contribute to the high palatability of foods rich both in fat and sugar.
Hydrolysis of Cellulose Using Ternary Mixtures of Purified Cellulases (1998)

The saccharification of microcrystalline cellulose by reconstituted ternary mixtures of purified cellulases (one endoglucanase and two cello-biohydrolases) has been studied over the entire range of mixture compositions. Ternary plots are used to compare the performance of five synthetic mixtures drawn from the cellulase systems of Acidothermus cel-lulolyticus, Trichoderma reesei, Thermomonospora fusca, and Thermotoga nea-politana. Results reveal that at least one synthetic mixture utilizing enzymes from three different organisms delivers performance competitive with that of a “native” (i.e., co-evolved) ternary system drawn exclusively from T. reesei. This heterologous system, consisting of the endoglucanase El from A. cellulolyticus and the exoglucanases CBHI from T. ressei and E3 from T. fusca, is forgiving from the system-design point of view, in that it delivers high saccharification rates over a wide range of mixture compositions.
Motility related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer. (1995)

In our previous studies we showed that motility related protein 1 (MRP-1) is a glycoprotein recognized by mAb M31-15, and that the sequence of MRP-1 is identical to that of CD9, a WBC differentiation antigen. Transfection of MRP-1/CD9 cDNA into cultured nonhematopoietic cells suppresses cell motility. The extent of suppression is directly related to the level of MRP-1/CD9 expression. In addition, the metastatic potential of MRP-1/CD9-transfected melanoma BL6 cells is lower than that of control BL6 cells. To determine whether these experimental results are of relevance with respect to actual human tumors, we investigated MRP-1/CD9 expression in 143 invasive ductal carcinomas of the breast. Of 97 patients with MRP-1/CD9-positive tumors, only 36 (37.1%) had lymph node involvement. In contrast, 21 of 39 (53.8%) patients whose tumors had reduced MRP-1/CD9 immunoreactivity and 5 of 7 patients whose primary carcinomas were not stained by the anti-MRP-1/CD9 MAb had lymph node metastases. The comparison of protein expression by 62 primary tumors and their respective metastatic lymph nodes revealed that in almost 50% of the cases, the latter had lower MRP-1/CD9 levels than the former. Moreover, reverse transcriptase-PCR-based analysis disclosed that MRP-1/CD9 gene expression in the metastatic lymph nodes of 17 of 32 patients was strikingly lower than in the primary invasive ductal carcinomas. Gene overexpression was not observed in any of the samples studied. Our data suggest that low MRP-1/CD9 expression may be associated with the metastatic potential of certain human tumors.
Study on Spheroidization of Tungsten Powders by RF Plasma Processing (2011)

Spherical tungsten powders were synthesized by (RF) argon plasma with irregular tungsten powders in this paper. The microstructure and crystallographic phases of the synthesized powders were characterized using scanning electron microscopy (SEM) and X-ray diffractometry (XRD). The results showed that fine spherical powder composed of pure tungsten phase with favorable dispersity and its surface becomes smooth. The spheroidization efficiency of synthesized powders was almost 100 %, and the particle size distribution became narrower after spheroidization treatment. The spheroidization efficiency of the sample decreases gradually as increasing of the feeding rate. The RF plasma spheroidization of tungsten powder is an ideal route synthesis of well- spherical metallic tungsten powders which is widely used in thermal spraying and metal injection moulding process.
Structure activity studies on the N-terminal region of glucagon (1984)

Using solid-phase methodology and preparative medium- and high-performance reverse-phase liquid chromatography, we have synthesized glucagon and its Arg12 analogue in approximately 5% yields. The synthetic glucagon was fully active relative to natural material, and the Arg12 peptide exhibited 50% activity. Since perhaps the most critical part of the glucagon-family peptides is the N-terminal hexapeptide region, both batches of resin were split during synthesis in order to prepare two series of analogues based on glucagon and [Arg12]glucagon with changes in the His-Ser-Gln-Gly-Thr-Phe sequence. The following new analogues were tested for their effects on blood glucose levels in normal male rats relative to glucagon and gave the following activities: [Ac-His1,Arg12]glucagon, 46%; [3-Me-His1,Arg12]glucagon, 30%; [Phe1,Arg12 )glucagon, 31%; [Des-His1,Arg12]glucagon, 4%; [D-Ala2,Arg12]glucagon, 44%; [D-p-Cl-Phe1,D-Ala4,Arg12]glucagon, 9%; [D-Phe4]glucagon, 655%; [Ala2]glucagon, 9%. These data indicate that the amino or imidazole nitrogens of the histidine residue are not essential for biological activity. However, an aromatic group in position 1 may be important, since the Phe1 analogue is almost as active as glucagon in our bioassay. The superagonist activity with [D-Phe4]glucagon, which was synthesized to test the hypothesis that a beta-bend conformation occurs at this position in glucagon by analogy with luteinizing hormone-releasing hormone and other Gly-containing peptides, indicates that this is indeed the case and has important implications for the receptor-recognition requirements of the glucagon-secretin-vasoactive intestinal peptide family of peptides.
Reflow and burial of channel waveguides formed in sol-gel glass on Si substrates (1993)

A reflow step and an improved burial procedure are demonstrated for channel waveguides formed in sol-gel glass on silicon substrates. Thick sol-gel films are deposited by repetitive spin coating and rapid thermal annealing, and etched to form ridge waveguides. Furnace heating is then used to melt both core and buffer layers simultaneously, providing a smooth surface for burial by further spin-coat deposition. Results are presented for typical core shapes, surface profiles after planarization, and optical insertion losses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Endocardial pacing site affects left ventricular end-diastolic volume and performance in the intact anesthetized dog. (1983)

We investigated how pacing from different endocardial sites affects the left ventricular three-dimensional contraction pattern and performance in intact anesthetized dogs. We used data from the motion of radiopaque markers implanted in the left ventricular endocardium in an analysis based on the polar decomposition theorem to determine the left ventricle's three-dimensional principal directions and magnitudes of deformation, and its axis and angle of rotation during the cardiac cycle. This paper also derives a new procedure that permits statistical comparison of different left ventricular cavity deformation patterns. During normal sinus rhythm and pacing from the right atrium, left ventricular septum, left ventricular apex, and right ventricular apex, the principal directions of left ventricular deformation remained relatively fixed with respect to the left ventricle's anatomy, independent of heart rate and pacing site. These directions were oriented in septum-free wall, anterior-posterior, and apex-base directions. End-systolic pressure and volume did not vary significantly among pacing sites. End-diastolic volume varied significantly among pacing sites, with right ventricular apical pacing producing the smallest end-diastolic and stroke volume. These results reveal that beats produced by right ventricular apical pacing eject less blood compared with beats produced by right atrial, left ventricular septal, or left ventricular apical pacing.
Nanoparticle Formation by Monomer-Starved Semibatch Emulsion Polymerization (2006)

Latexes with very small particle size are usually manufactured by microemulsion polymerization. This article explains the preparation of nanolatexes by monomer-starved nucleation in a conventional semibatch emulsion polymerization with a low surfactant/monomer ratio and with no need for a cosurfactant. The semibatch emulsion polymerization reactions started with an aqueous solution of a surfactant and a water soluble initiator. Monomer was added at a fixed rate. The size of particles decreased with decreasing rate of monomer addition. High solids content nanolatexes with particles as small as 25 nm in diameter were produced. Several monomers with different water solubilities were compared. The order of the number of particles in terms of the rate of monomer addition was found to depend on the type of monomer. Water soluble monomers produced more particles due to associated chain transfer to monomer and radical exit. The monodispersity of particles at the end of nucleation increased as the rate of monomer addition decreased. The technique seems to be preferable to microemulsion polymerization, which uses a high concentration of surfactant/cosurfactant and is limited to low monomer holdup.
Patterning of Self-Assembled Films Using Lithographic Exposure Tools (1993)

This paper presents an approach for fabricating surfaces with precise positional control of chemical functionalities at submicron resolutions using direct patterning of organosilane self-assembled monolayer films (SAFs) with lithographic exposure tools. Although the process is of general applicability, microelectronics applications are emphasized here. The suitability of monolayer SAFs for high resolution patterning is discussed and deep UV photochemical mechanisms for several classes of SAFs are presented. Selective electroless metallization of patterned SAFs provides sufficient plasma etch resistance and compatibility with current microelectronics processing technologies to allow fabrication of functioning Si MOSFET test structures. Unique features of the process, including an ability to utilize a variety of substrates and control metal film adhesion by judicious choice of the SAF, are discussed.
Feedforward Control Using Sampled-Data Polynomial for Track Seeking in Hard Disk Drives (2008)

To decrease the seek time of hard disk drives, a feedforward control method was developed by using a sampled-data polynomial. The sampled-data polynomial satisfies the boundary conditions that include the characteristics of the zero-order hold, and compensates for the discretization error caused by the zero-order hold without the need for complicated calculations. Therefore, the feedforward control using the sampled-data polynomial enables real-time calculation and does not require lookup tables which need a large amount of memory. The parameters of the sampled-data polynomial are designed by using shock-response-spectrum analysis to minimize the settling vibrations caused by the feedforward control inputs. When the proposed method was applied on a hard disk drive, it significantly reduced the amount of tracking error in the seek control and also reduced the seek time.
Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults (2011)

In contrast to conventional homografts and xenografts, decellularized fresh allograft valves showed improved freedom from explantation, provided low gradients in follow-up, and exhibited adaptive growth.
Breast cancer biomarkers and molecular medicine (2003)

The first part of this two-part review of established and emerging breast cancer biomarkers and molecular diagnostics considers breast cancer predisposition, screening tests for diagnosis, diagnosis using small specimens and metastatic lesions, micrometastatic disease and breast cancer prognosis assessment. Prognostic factors covered in this review include: cytogenetic markers, DNA ploidy and S phase determination, cell proliferation markers, cell cycle regulators and growth factor measurements including epithelial growth factor receptor, HER-2/neu and a variety of other relevant molecules controlling proliferation, differentiation and angiogenesis. The first section of part two will continue the consideration of breast cancer prognostic factors including oncogenes, tumor suppressor genes, cell adhesion molecules, invasion-associated proteins and proteases, hormone receptor proteins, drug resistance proteins, apoptosis regulators, transcription factors, telomerase, DNA repair and methylation and transcriptional profiling using high-density genomic microarrays. The second section of part two will consider the prediction of therapy response using the techniques of pharmacogenetics and pharmacogenomics.
A novel melanoma gene (MG50) encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes. (2000)

We identified a novel 8.1-kb human melanoma gene, MG50, derived from subtractive hybridization with a squamous lung carcinoma cell line, LU-1. 6.8 kb containing an open reading frame were sequenced, and the structure of the encoded 1496 amino acid protein was deduced. With HLA-A2.1-transduced Drosophila cells as antigen-presenting cells, we identified six epitopes restricted by HLA-A2.1 that elicited CTLs in vitro. Reactivity of the CTLs to melanoma cells containing MG50 indicated that the epitopes were displayed naturally. Significant cross-reactivity of CTLs immunized against a melanoma cell line that lacked HLA-A2.1 indicated that at least four of the epitopes were also recognized in a different HLA class I context, most likely HLA-A*6802. By quantitative reverse transcription, MG50 message was found in one of two skin melanoma cell lines, an ocular melanoma cell line, two of four metastatic skin melanomas, two of three mammary carcinomas, one of two colon carcinomas, and an ovarian carcinoma. Of six normal tissues, MG50 was found only in a specimen of normal skin and was absent from a congenital nevus. It is likely that MG50 is the gene for the interleukin 1 receptor antagonist because a reported sequence of cDNA from the latter had a sequence of 528 bases in the 3' region, a long contiguous base sequence, and 176 encoded amino acids identical with those of MG50. MG50 is one of the few melanoma-associated antigens that is not a differentiation antigen or a mutated protein. Because of its nature, it may prove to be important in the pathogenesis of the tumors in which it is found, as well as an immunogen and target for immunotherapy.