gebhart/patrepeval huggingface dataset:
Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients (2007)

Adults with primary malignant glioma have an unacceptably poor outcome. Most of these tumors recur at or adjacent to the site of origin, which indicates that failure to eradicate local tumor growth is a major factor contributing to poor outcome. Therefore, locoregional therapies may improve local control and overall outcome for malignant glioma patients. Malignant gliomas selectively express several factors that are not present on normal CNS tissue. Regional administration of radiolabeled monoclonal antibodies targeting tumor-specific antigens expressed by malignant gliomas offers an innovative therapeutic strategy that has recently demonstrated encouraging antitumor activity and acceptable toxicity in clinical trials at a number of centers. Most studies have utilized monoclonal antibodies against tenascin-C, an extracellular matrix glycoprotein ubiquitously expressed by malignant gliomas. This review summarizes clinical trials performed using radiolabeled antitenascin-C monoclonal antibodies for malignant glioma patients to date and highlights future plans to further develop this therapeutic strategy.
Initial Experiments on the End-Point Control of a Flexible One-Link Robot (1984)

It has been known for some time ( Gevarter 1970) that if a flexible structure is controlled by locating every sensor exactly at the actuator it will control, then stable operation is easy to achieve. Nearly all commercial robots are controlled in this way, for this reason. So are most flexible spacecraft. Conversely, when one attempts to control a flexible struc ture by applying control torques at one end that are based on a sensor at the other end, the problem of achieving stability is severe. Solving it is an essential step for better control in space: the space-shuttle arm is a cogent example. The next generation of industrial robots will also need such control capability, for they will need to be much lighter in weight ( to achieve quick response with modest energy), and they will need to achieve greater precision by employing end-point sensing. A set of experiments has been constructed to demonstrate control strategies for a single-link, very flexible manipulator, where the position of one end is to be sensed and precisely positioned by torquing at the other end. The objective of this first set of experiments is to uncover and solve problems related to the control of very flexible manipulators where sen sors are not colocated with the actuator. The experimental arrangement described here is also a test bed for new designs for flexible-structure controllers, designs that use insensitive, reduced-order control and adaptive control methods, for example. This paper describes the experimental arrangement, model identification, control design, and first experimental results. Some interesting results are the following. First, good stability can be achieved for such noncolocated systems, and reponse can be achieved that is effectively three times faster than the first natural cantilever period of the system: but a good model of the system dynamics and rather sophisticated control algorithms are essential to doing so. Even then, the system will always be conditionally stable. In addition to the tip sensor, a colocated rate sensor and nearly colocated strain gauges have been found to be very useful for achieving good closed-loop performance, that is, high gain and high band width. Second, there is an ultimate physical limit to achiev able response time, namely, the time required for a wave to travel the length of the member. Well-designed controllers can approach this limit. Third, the use of end-point sensing makes less critical the elaborate dynamic conditioning of position-command signals— "model-following " differentia tors, feed-forward, and the like—such as are typically needed in present-generation robots that use "dead reckoning" in lieu of end-point sensing. With end-point sensing, feedback alone ( suitably conditioned) is sufficient to whip the tip to the commanded position and hold it there precisely. Even more important, a shift in, for example, workpiece with respect to robot base, no longer produces an error.
Nicotinamide Adenine Dinucleotide Phosphate Fluorescence and Absorption Monitoring of Enzymic Activity in Silicate Sol-Gels for Chemical Sensing Applications (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNicotinamide Adenine Dinucleotide Phosphate Fluorescence and Absorption Monitoring of Enzymic Activity in Silicate Sol-Gels for Chemical Sensing ApplicationsStacey A. Yamanaka, Bruce Dunn, Joan S. Valentine, and Jeffrey I. ZinkCite this: J. Am. Chem. Soc. 1995, 117, 35, 9095–9096Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ja00140a038https://doi.org/10.1021/ja00140a038research-articleACS PublicationsRequest reuse permissionsArticle Views222Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chromosomal stabilisation by a subtelomeric rearrangement involving two closely related Alu elements (1996)

We have characterised a subtelomeric rearrangement involving the short arm of chromosome 16 that gives rise to alpha-thalassaemia by deleting the major, remote regulatory element controlling alpha-globin expression. The chromosomal breakpoint lies in an Alu family repeat located only approximately 105 kb from the 16p subtelomeric region. The broken chromosome has been stabilised with a newly positioned telomere acquired by recombination between this 16p Alu element and a closely related subtelomeric Alu element of the Sx subfamily. It seems most likely that this abnormal chromosome has been rescued by the mechanism of telomere capture which may reflect a more general process by which subtelomeric sequences are normally dispersed between chromosomal ends.
6,7-disubstituted 2,4-diaminopteridines: novel inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase (1996)

Four novel, disubstituted diaminopteridines have been identified which antagonize the uptake of a folate precursor (para-aminobenzoic acid) by rat-derived Pneumocystis carinii maintained in short-term axenic culture at concentrations ranging from 4.5 to 26 microM. The compounds were at least 10 to 100 times more active than trimethoprim in this assay. None of these entities exhibited toxicity to mammalian cell lines at < 100 microM. The same structures also caused significant inhibition of Toxoplasma gondii tachyzoite replication within Madin-Darby bovine kidney cells at concentrations ranging from 0.1 to 10 microM. Three of the structures (GR92754, AH10639, and AH2504) were at least an order of magnitude more potent than the standard anti-T. gondii agent, pyrimethamine. All three entities were also significantly more potent and selective than pyrimethamine as inhibitors of T. gondii dihydrofolate reductase (DHFR), with 50% inhibitory concentrations within the range of 0.018 to 0.033 microM. One of these compounds, 6,7-dibutyl-2,4-diaminopteridine (GR92754), was also a potent and selective inhibitor of P. carinii DHFR (50% inhibitory concentration, 0.082 microM). GR92754 is the first DHFR inhibitor described that exhibits greater potency, selectivity, and intracellular activity against both organisms than any of the DHFR agents used clinically, namely, trimethoprim, pyrimethamine, and trimetrexate. This information could provide the starting point for examination of the pharmacokinetic and therapeutic potential of GR92754 and related chemical entities with animal models.
Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound. (1997)

Heparan sulfate (HS) proteoglycans play a key role in cell proliferation induced by basic fibroblast growth factor (FGF-2) and other heparin-binding growth factors. To modulate the involvement of HS, we have used a synthetic, nonsulfated polyanionic aromatic compound (RG-13577) that mimics functional features of heparin/HS. FGF-2-stimulated proliferation of vascular endothelial cells was markedly inhibited in the presence of 5-10 microg/ml compound RG-13577 (poly-4-hydroxyphenoxy acetic acid; Mr approximately 5 kD). Direct interaction between RG-13577 and FGF-2 was demonstrated by the ability of the former to compete with heparin on binding to FGF-2. RG-13577 inhibited FGF-2 binding to soluble- and cell surface-FGF receptor 1 (FGFR1). Unlike heparin, RG-13577 alone failed to mediate dimerization of FGF-2. Moreover, it abrogated heparin-mediated dimerization of FGF-2 and FGFR1, as well as FGF-2 mitogenic activity in HS-deficient F32 lymphoid cells. The antiproliferative effect of compound RG-13577 was associated with abrogation of FGF-2-induced tyrosine phosphorylation of FGFR1 and of cytoplasmic proteins involved in FGF-2 signal transduction, such as p90 and mitogen-activated protein kinase. A more effective inhibition of tyrosine phosphorylation was obtained after removal of the cell surface HS by heparinase. In contrast, tyrosine phosphorylation of an approximately 200-kD protein was stimulated by RG-13577, but not by heparin or FGF-2. RG-13577 prevented microvessel outgrowth from rat aortic rings embedded in a collagen gel. Development of nontoxic polyanionic compounds may provide an effective strategy to inhibit FGF-2-induced cell proliferation associated with angiogenesis, arteriosclerosis, and restenosis.
A locally quadratic model of the motion estimation error criterion function and its application to subpixel interpolations (1996)

Accurate motion estimation is essential to effective motion compensated video signal processing, and subpixel resolutions are required for high quality applications. It is observed that around the optimum point of the motion estimation process the error criterion function is well modeled as a quadratic function with respect to the motion vector offsets. This locally quadratic functional model decomposes the motion estimation optimization at subpixel resolutions into a two-stage pipelinable processes: full-search at full-pixel resolution and interpolation at any subpixel resolution. Practical approximation formulas lead to the explicit computations of both motion vectors and error criterion functional values at subpixel resolutions.
Pharmacokinetics, Pharmacodynamics, and Safety of ASP015K (Peficitinib), a New Janus Kinase Inhibitor, in Healthy Subjects (2016)

Two randomized, double-blind, placebo-controlled studies are reported that had the objective to evaluate the pharmacokinetics, pharmacodynamics, and safety of ASP015K (peficitinib), a Janus kinase (JAK) inhibitor, in healthy subjects. The single-dose study included 7 male groups (3-300 mg) and 2 female groups (30 or 200 mg), n = 8/group (6 on ASP015K and 2 on placebo in each group). The multiple-dose study included 1 female and 3 male groups, n = 12/group (9 on ASP015K and 3 on placebo in each group), who received ASP015K (30 mg) or placebo every 12 hours (twice a day) for 14 days. In the single-dose study, plasma ASP015K concentration increased dose-proportionally. Food increased ASP015K exposure (AUC<sub>inf</sub> ) by 27%. Mean peak JAK inhibition increased with dose, from 6% at 4 hours (median) following ASP015K 3 mg to 93% (range, 89%-98%) at 2 hours (median) after ASP015K 300 mg. In the multiple-dose study, ASP015K plasma exposure reached steady state by day 3. On day 14, mean ASP015K peak concentration was 38%-65% higher than after the first dose; peak JAK inhibition following 100 or 200 mg twice daily was >85%. The most common adverse events (AEs) were neutropenia, headache, and abdominal pain; no serious AEs occurred. The safety findings at pharmacologically effective doses of ASP015K support further clinical development.
Carboxylase Overexpression Effects Full Carboxylation but Poor Release and Secretion of Factor IX:  Implications for the Release of Vitamin K-Dependent Proteins (2002)

Vitamin K-dependent (VKD) proteins are modified by the VKD carboxylase as they transit through the endoplasmic reticulum. In a reaction required for their activity, clusters of Glu's are converted to Gla's, and fully carboxylated VKD proteins are normally secreted. In mammalian cell lines expressing high levels of r-VKD proteins, however, under- and uncarboxylated VKD forms are observed. Overexpression of r-carboxylase does not improve carboxylation, but the lack of effect is not understood, and the intracellular events that occur during VKD protein carboxylation have not been investigated. We analyzed carboxylation in 293- and BHK cell lines expressing r-factor IX (fIX) and endogenous carboxylase or overexpressed r-carboxylase. The fIX secreted from the four cell lines was highly carboxylated, indicating fIX-carboxylase engagement during intracellular trafficking. The r-carboxylase was functional for carboxylation: overexpression resulted in a proportional increase in fIX-carboxylase complexes that yielded full fIX carboxylation. Interestingly, the carboxylated fIX product was not efficiently released from the carboxylase in r-fIX/r-carboxylase cells, resulting in decreased fIX secretion. r-Carboxylase overexpression changed the ratios of intracellular fIX to carboxylase, and we therefore developed an in vitro assay to test whether fIX levels affect release. FIX-carboxylase complexes were in vitro carboxylated with or without excess VKD substrate or propeptide. These analyses are the first to dissect the rates of release versus carboxylation and showed that release was much slower than carboxylation. In the absence of excess VKD substrate/propeptide, fIX in the fIX-carboxylase complex was fully carboxylated by 10 min, but 95% was still complexed with carboxylase after 30 min. The presence of excess VKD substrate/propeptide, however, led to a significant increase in VKD product release, possibly through a second propeptide binding site in the carboxylase. The intracellular analyses also showed that the fIX carboxylation rate was slow in vivo and was similar in r-fIX versus r-fIX/r-carboxylase cells, despite the large differences in carboxylase levels. The results suggest that the vitamin K cofactor may be limiting for carboxylation in the cell lines.
Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. (1990)

Uricase (UC) was conjugated with dextran and polyethylene glycol and their biochemical and biopharmaceutical properties were studied. UC-dextran conjugates (UC-D) synthesized by four methods, periodate oxidation, cyanogen bromide, carbodiimide and cyanuric chloride largely retained the UC enzymatic activity depending on the extent to which they modified amino groups. The periodate oxidation method seemed best because it gave a conjugate with high yield and satisfactory activity retention. The conjugate of UC with activated polyethylene glycol (UC-PEG2) was also obtained with high yield but the remaining activity was somewhat lower than those of dextran conjugates at the same modification extent. UC-D and UC-PEG2 showed sustained enzymatic activity in plasma after intravenous injection to rats. The advantage of chemical modification of proteins, especially with dextran, by the periodate oxidation method for preparation of a protein-delivery system was thus suggested.
Effect of Bond-Length Alternation in Molecular Wires (2002)

Current-voltage (I-V) characteristics for metal-molecule-metal junctions formed from three classes of molecules measured with a simple crossed-wire molecular electronics test-bed are reported. Junction conductance as a function of molecular structure is consistent with I-V characteristics calculated from extended Hückel theory coupled with a Green's function approach, and can be understood on the basis of bond-length alternation.
Regulating Information Security in the Government Contracting Industry: Will the Rising Tide Lift All the Boats? (2013)

The government is strengthening cyber and information security regulations to address increasing cybersecurity risks.These regulations will affect government contractors in many ways; for instance, contractors must apply new technologies to monitor cybersecurity threats and develop stronger information security protections.This "rising tide" of regulation should lift "all boats," namely members of the government contracts sector.Some small business contractors or larger contractors without experience working with the government, however, may not be equipped to fully comply with these strengthened regulations.The government may as a result lose a number of would-be competitors for contracts requiring cyber and information security protections.Alternatively, some contractors lacking resources and experience may compete for the contracts anyway, which could serve to weaken the security of government information and information systems.This Article gives an overview of existing and new regulatory requirements and analyzes
Sorting and hardware assisted rendering for volume visualization (1994)

We present some techniques for volume rendering unstructured data. Colors and opacities are interpolated between vertices using hardware assisted texture mapping.
Optimal minimal neural interpretation of spectra (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimal minimal neural interpretation of spectraClaus. Borggaard and Hans Henrik. ThodbergCite this: Anal. Chem. 1992, 64, 5, 545–551Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ac00029a018https://doi.org/10.1021/ac00029a018research-articleACS PublicationsRequest reuse permissionsArticle Views551Altmetric-Citations225LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5 (1994)

Neither monoclonal antibody was as effective as bactericidal/permeability-increasing protein at binding or neutralizing endotoxin in vitro or in vivo. The potent endotoxin-binding and -neutralizing properties of bactericidal/permeability-increasing protein indicate that it might be useful in the treatment of endotoxin-related disorders in humans.
Conversion of cysteine to formylglycine: A protein modification in the endoplasmic reticulum (1997)

In sulfatases a Calpha-formylglycine residue is found at a position where their cDNA sequences predict a cysteine residue. In multiple sulfatase deficiency, an inherited lysosomal storage disorder, catalytically inactive sulfatases are synthesized which retain the cysteine residue, indicating that the Calpha-formylglycine residue is required for sulfatase activity. Using in vitro translation in the absence or presence of transport competent microsomes we found that newly synthesized sulfatase polypeptides carry a cysteine residue and that the oxidation of its thiol group to an aldehyde is catalyzed in the endoplasmic reticulum. A linear sequence of 16 residues surrounding the Cys-69 in arylsulfatase A is sufficient to direct the oxidation. This novel protein modification occurs after or at a late stage of cotranslational protein translocation into the endoplasmic reticulum when the polypeptide is not yet folded to its native structure.
Clinical trial of a novel surface cooling system for fever control in neurocritical care patients* (2004)

The Arctic Sun Temperature Management System is superior to conventional cooling-blanket therapy for controlling fever in critically ill neurologic patients.
Women Empowerment and Sustainable Development Goals- Planet 50-50 by 2030; are we on the right track? (2017)

Women and girls are almost half the world’s population and they are on the fronts that’s why often more intensely impacted than other genders by poverty, weather change, food uncertainty, lack of healthcare, and worldwide economic crises. Their contributions are central to outcomes. With the new global 2030 roadmap and Sustainable Development Goals (SDGs) advised by UN Member States on 25 September 2015, included aspects on how women are affected by each of the 17 proposed SDGs, as well as how women and girls can be key to achieving each of these goals.
BayesCall: A model-based base-calling algorithm for high-throughput short-read sequencing (2009)

Extracting sequence information from raw images of fluorescence is the foundation underlying several high-throughput sequencing platforms. Some of the main challenges associated with this technology include reducing the error rate, assigning accurate base-specific quality scores, and reducing the cost of sequencing by increasing the throughput per run. To demonstrate how computational advancement can help to meet these challenges, a novel model-based base-calling algorithm, BayesCall, is introduced for the Illumina sequencing platform. Being founded on the tools of statistical learning, BayesCall is flexible enough to incorporate various features of the sequencing process. In particular, it can easily incorporate time-dependent parameters and model residual effects. This new approach significantly improves the accuracy over Illumina's base-caller Bustard, particularly in the later cycles of a sequencing run. For 76-cycle data on a standard viral sample, phiX174, BayesCall improves Bustard's average per-base error rate by ∼51%. The probability of observing each base can be readily computed in BayesCall, and this probability can be transformed into a useful base-specific quality score with a high discrimination ability. A detailed study of BayesCall's performance is presented here.