gebhart/patrepeval huggingface dataset:
An Electronic Design Methodology For Adaptive Control Systems (2008)

i-manager's Journal on Future Engineering and Technology, i-manager's Journal on Software Engineering, i-manager's Journal on Electrical Engineering, i-manager's Journal on Electronics Engineering, i-manager's Journal of Educational Technology, i-manager's Journal on Educational Psychology, i-manager's Journal on School Educational Technology, i-manager's Journal on English Language Teaching, i-manager's Journal on Mechanical Engineering, i-manager's Journal on Civil Engineering, i-manager's Journal on Embedded Systems, i-manager's Journal on Information Technology, i-manager's Journal on Structural Engineering, i-manager's Journal on Communication Engineering and Systems, i-manager's Journal on Wireless Communication Networks, i-manager's Journal on Instrumentation and Control Engineering, i-manager's Journal on Circuits and Systems, i-manager's Journal on Digital Signal Processing, i-manager's Journal on Power Systems Engineering, i-manager's Journal on Computer Science, i-manager's Journal on Material Science, i-manager's Journal on Cloud Computing, i-manager's Journal on Image Processing, i-manager's Journal on Mobile Applications and Technologies, i-manager's Journal on Pattern Recognition, i-manager's Journal on Mathematics, i-manager's Journal on Management, i-manager's Journal on Nursing, i-manager's Journal on Physical Sciences, i-manager's Journal on Chemical Sciences, i-manager's Journal on Economics & Commerce , i-manager's Journal on Humanities & Social Sciences, i-manager's Journal on Life Sciences , i-manager's Journal on Construction Management, i-manager's Oyla , ,India best Journal Publication Website,World Best Plication SIte,Free atrticle published website,Journal Publised,Published Journal,Research Paper Published,indian research paper publications,how to published your article/research paper in india for free,journal’s instructions for authors
The LDAP URL Format (1997)

This document specifies an Internet standards track protocol for the Internet community, and requests discussion and suggestions for improvements. Please refer to the current edition of the &amp;quot;Internet Official Protocol Standards &amp;quot; (STD 1) for the standardization state and status of this protocol. Distribution of this memo is unlimited. LDAP is the Lightweight Directory Access Protocol, defined in [1] and [2]. This document describes a format for an LDAP Uniform Resource Locator which will allow Internet clients to have direct access to the LDAP protocol. While LDAP currently is used only as a front end to the X.500 directory, the URL format described here is general enough to handle the case of stand-alone LDAP servers (i.e., LDAP servers not back-ended by X.500). 2. URL Definition An LDAP URL begins with the protocol prefix &amp;quot;ldap &amp;quot; and is defined by the following grammar. &amp;lt;ldapurl&amp;gt;:: = &amp;quot;ldap:// &amp;quot; [ &amp;lt;hostport&amp;gt;] &amp;quot;/ &amp;quot; &amp;lt;dn&amp;gt; [ &amp;quot;? &amp;quot; &amp;lt;attributes&amp;gt; [ &amp;quot;? &amp;quot; &amp;lt;scope&amp;gt; &amp;quot;? &amp;quot; &amp;lt;filter&amp;gt;]] &amp;lt;hostport&amp;gt;:: = &amp;lt;hostname&amp;gt; [ &amp;quot;: &amp;quot; &amp;lt;portnumber&amp;gt;] &amp;lt;dn&amp;gt;:: = a string as defined in RFC 1485
Recent advances of exosomes in immune modulation and autoimmune diseases (2016)

Exosomes are small membrane-bound vesicles (30-100 nm) that are secreted by different types of cells and they have been well documented to resemble saucers or flattened spheres under the electron microscope. Recently, evidence indicates that exosomes play important roles in the immune modulation and are associated with the immune pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA), Sjogren's syndrome (SS) and systemic lupus erythematosus (SLE). In this review, we will summarize current research advances of exosomes in immunoregulation, pathogenesis, diagnosis and therapeutics of autoimmune diseases.
Favorable Metabolism and Pharmacokinetics of Formulations of XP23829, a Novel Fumaric Acid Ester, in Healthy Subjects (P05.189) (2013)

OBJECTIVE: To assess the pharmacokinetics (PK), safety and tolerability of four XP23829 formulations.
International industry migration and firm characteristics: some evidence from the analysis of firm data (2010)

This article examines firm characteristics associated with the probability of relocating part of the activity in a foreign country. Using manufacturing firms’ micro data for the 1999-2005 period, we find evidence that cost-cutting objectives are the main determinants for offshoring production, that firms with lower profits are more likely to undertake in-house offshoring, and that imports from low-wage countries increase the likelihood that part of the activity will be relocated. We also find that most offshoring firms are foreign – nearly 76% of the total.
[LDL-receptor-related protein]. (1994)

The LDL-receptor-related protein is a multifunctional endocytotic receptor that clear apo E- and/or lipoprotein lipase-enriched lipoproteins, proteases such as alpha 2-macroglobulin plasminogen and activator inhibitor-1 (PAI-1), Pseudomonas exotoxin A and probably vitellogenin from blood circulation. Its role in plasma chylomicron remnant clearance has been postulated, and recently has been demonstrated by using its inhibitor; receptor-associated protein (RAP) in LDL receptor knockout mice.
Development of novel peptide ligands modulating the enzyme activity of prostate-specific antigen (2000)

Prostate-specific antigen (PSA) is a serine proteinase produced mainly by epithelial cells of the prostate. Measurement of PSA in serum is widely used for diagnosis and monitoring of prostate cancer. The major problem of the PSA determination in early diagnosis is the high false positive rate due to benign prostatic hyperplasia, but the clinical accuracy can be improved by determining the proportions of various molecular forms of PSA. The main biological function of PSA is liquefaction of the seminal gel formed after ejaculation, but PSA has also been suggested to regulate invasiveness and metastatic potential of prostatic tumors. Thus, agents binding to and affecting the function of PSA have the potential to be used for diagnosis and therapy of prostate cancer. We have developed peptides specific for PSA by using cyclic phage display peptide libraries. After deducing the amino acid sequence of the peptides by sequencing the relevant part of phage genome, the peptides were expressed as glutathione-S-transferase (GST) fusion proteins or produced by chemical synthesis. The peptides were shown to bind to PSA specifically as indicated by lack of binding to other related serine proteinases. The binding of the peptides with PSA was strongly inhibited by monoclonal antibodies specific for free PSA and they did not bind to PSA-inhibitor complexes indicating that they bind close to the active site of the enzyme. Most of the peptides enhanced the enzyme activity of PSA against a chromogenic substrate. The affinity of the peptides could be increased by including Zn2+ in the reaction mixture. These results show that peptides that bind to PSA and modulate its enzyme activity can be developed by phage display techniques. These peptides have the potential to be used for targeting of prostatic tumors and diagnostics of prostate cancer.
Injectable bone cements for use in vertebroplasty and kyphoplasty: State‐of‐the‐art review (2005)

Vertebroplasty (VP) and kyphoplasty (KP) are minimally invasive surgical procedures that have recently been introduced for the medical management of osteoporosis-induced vertebral compression fractures. The aim of VP is to stabilize the fractured vertebral body, while the goals of KP are to stabilize the fractured vertebral body and to restore its height to as near its prefracture level as possible. Both procedures involve injection of the setting dough of an injectable bone cement (IBC) into the fractured vertebral body, thereby highlighting the indispensable role that the IBC plays. Although there is a very large literature on IBCs, no detailed critical review of it has been published. Such a review is the subject of the present work, which is in seven parts. The review opens with a succinct introduction to VP and KP. The topics covered in the parts that follow are: (1) a listing of the 18 most desirable properties of an IBC (e.g., easy injectability, high radiopacity, and a resorption rate that is neither too high nor too low); (2) descriptions of the four classes of IBCs (calcium phosphates, acrylic bone cements, calcium sulfates, and composites); (3) concerns that have been raised with regard to the use of IBCs (such as the potential for thermal necrosis of tissue at the peri-augmentation site, when an acrylic bone cement is used); (4) explicative summaries of the main findings of literature studies on the influence of nine factors (such as powder particle size, powder-to-liquid ratio, and the method used to mix the powder and the liquid) on the values of various properties of IBCs; (5) explicative summaries of the main findings of literature studies on five fundamental matters, such as the aging mechanism of the powder, the thermokinetics of a setting dough, and the influence of the type of IBC used on various ex vivo biomechanical performance measures of VP- and KP-augmented vertebral bodies; and (6) descriptions of topics in six areas for future research, such as the determination of an overall index of the fatigue performance of an IBC and the development of internationally recognized standardized testing protocols to employ when a synthetic cancellous bone void model is used in the rapid in vitro screening of IBCs. The review ends with a summary of the most salient points and observations made.
ChemInform Abstract: Synthesis of 2′‐α‐C‐Allenyl‐2′‐deoxyuridine: An Analogue of 2′‐Azido‐2′‐deoxyuridine, Known Inhibitor of Ribonucleotide Diphosphate Reductase (RDPR). (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Survival of patients surgically treated for stage I lung cancer. (1981)

When the TNM staging system of the American Joint Committee (AJC) for Cancer Staging and End-Results Reporting was applied to 3,912 patients seen during a 6 year period at the Mayo Clinic, 624 (16%) fulfilled the criteria for postsurgical pathological Stage I non-small cell bronchogenic carcinoma. Of these 624 patients, 129 were excluded from further survival analysis for various reasons. The remaining 495 consisted of two groups: 350 patients who were enrolled within 30 days into a prospective postoperative 4 monthly follow-up program and 145 patients who were enrolled later or were followed less frequently. Because no significant difference was noted in survival rates between these groups, data were pooled. Of the combined group of 495 patients, 84% survived lung cancer for 2 years and 69% of 5 years (actuarial estimation). The survival of patients classified T1 N0 M0 (91% alive at 2 years and 80% at 5 years) is so good that it seems unlikely that adjuvant therapy in this group could demonstrate improved survival. In addition to TNM classification, age at operation, sex, and extent of operation were important determinants of survival.
Characterization and low temperature test of the flexibly crosslinked polyurethane copolymer by poly(dimethylsiloxane) (2012)

Shape memory polyurethane (SMPU) flexibly crosslinked by a hydrophobic poly(dimethylsiloxane) (PDMS) spacer at its side through allophanate bonding was tested for shape recovery at −30 °C and compared to a linear SMPU. The SMPU was composed of 4,4′-methylenebis(phenylisocyanate) (MDI), poly(tetramethyleneglycol) (PTMG), 1,4-butanediol (BD), and PDMS that was connected to SMPU chains by a second MDI. The mechanical and shape memory properties of two types of SMPU, differing in PTMG and PDMS content, were compared. In the best case, a 283% increase in maximum stress compared to the linear polymer was attained without any sacrifice of strain. Shape recovery at 45 °C increased to 91% and remained at more than 80% after four cyclic tests. Shape recovery at 0 °C could be improved by increasing PDMS content, and the critical shape recovery temperature decreased with increasing PDMS content. The PDMS-crosslinked SMPU demonstrated instant shape recovery at −30 °C in comparison with the linear SMPU that must be warmed to room temperature for complete shape recovery. The extraordinary shape memory results were analyzed and are discussed together with differential scanning calorimetry and infrared data.
Desorption Electrospray Ionization (DESI) Analysis of Intact Proteins/Oligopeptides (2008)

INTRODUCTIONDesorption electrospray ionization (DESI) is amenable to the study of intact proteins in complex mixtures, including blood or other biological media. Intact proteins can be desorbed and ionized from the surface under gentle (soft) conditions to produce compact conformations of the protein. A procedure for DESI analysis of intact proteins and oligopeptides using mass spectrometry (MS) is described here. DESI-MS is an emerging technique with great promise, but its application range is still being investigated. Therefore, the protocol presented here provides general procedures used for the applications that have been investigated so far. Optimal ion source parameters and surface types may vary depending on the application.
Are Insights Gained from NOD Mice Sufficient to Guide Clinical Translation? (2007)

Despite decades of research using various animal models for type 1 diabetes, we are still struggling to define the initiating autoantigens, the precise mechanisms of beta cell destruction, and suitable immune-based interventions to prevent or treat human diabetes. Animal models, such as the non-obese diabetic (NOD) mouse and the biobreeding (BB) rat, develop immune-mediated diseases with features resembling type 1 diabetes in humans. Although these animal models of autoimmune diabetes have proved to be valuable tools to study certain aspects of the disease process, they have also led to misconceptions and erroneous extrapolations, as well as false expectations with regard to the efficacy of immunotherapy. It is therefore time to ask ourselves whether we are making major strategic mistakes when employing rodent models for the study of type 1 diabetes. This review will describe where rodent models have provided us with proper guidance and where they have misled us, concluding that each model only offers partial information with undefined clinical value. Therefore, a more critical attitude and repetition of crucial observations in different model settings will be necessary in the future. I will argue that animal models have limited but evident value when it comes to teaching us about type 1 diabetes in humans, and we can take advantage of this value more efficiently.
Multiple isoforms of CD46 (membrane cofactor protein) serve as receptors for measles virus. (1994)

Measles virus (MV) causes a productive infection in humans and certain simian hosts. Rodent cells such as Chinese hamster ovary (CHO) and murine cell lines normally resist MV infection. Human CD46, or membrane cofactor protein, a complement regulatory protein, recently has been reported as the cellular receptor for MV. Multiple isoforms of the CD46 protein exist; four of these isoforms are commonly expressed on human cells. Expression of each of the four isoforms in CHO cells followed by exposure to MV led to the appearance of viral proteins within the cells and on the cell surface as detected by immunofluorescence. Syncytium formation also was observed in the cultures. CHO cells expressing any of the four isoforms and exposed to MV formed infectious centers when plated on Vero cell monolayers, indicating that the cells can transmit virus to uninfected cells. The murine cell line MC57 expressing the BC1 isoform of CD46 also stained positively for MV antigens and was positive in the infectious center assay after exposure to MV. Treatment of CD46-expressing cells with antibody to human CD46 inhibited MV binding in a dose-dependent manner. These observations indicate that any of the four primary isoforms of CD46 are able to serve as a receptor for MV.
Hardware-rooted trust for secure key management and transient trust (2007)

We propose minimalist new hardware additions to a microprocessor chip that protect cryptographic keys in portable computing devices which are used in the field but owned by a central authority. Our authority-mode architecture has trust rooted in two critical secrets: a Device Root Key and a Storage Root Hash, initialized in the device by the trusted authority. Our architecture protects trusted software, bound to the device, which can use the root secrets to protect other sensitive information for many different usage scenarios. We describe a detailed usage scenario for crisis response, where first responders are given transient access to third-party sensitive information which can be securely accessed during a crisis and reliably revoked after the crisis is over.
Formality of Language: definition, measurement and behavioral determinants (1999)

. A new concept of formality of linguistic expressions is introduced and argued to be the most important dimension of variation between styles or registers. Formality is subdivided into &amp;quot;deep&amp;quot; formality and &amp;quot;surface&amp;quot; formality. Deep formality is defined as avoidance of ambiguity by minimizing the context-dependence and fuzziness of expressions. This is achieved by explicit and precise description of the elements of the context needed to disambiguate the expression. A formal style is characterized by detachment, accuracy, rigidity and heaviness; an informal style is more flexible, direct, implicit, and involved, but less informative. An empirical measure of formality, the F-score, is proposed, based on the frequencies of different word classes in the corpus. Nouns, adjectives, articles and prepositions are more frequent in formal styles; pronouns, adverbs, verbs and interjections are more frequent in informal styles. It is shown that this measure, though coarse-grained, adequately disti...
Family influences on adolescent sexual and contraceptive behavior (2002)

Studies of adolescent pregnancy risk are relevant to understanding responsible adolescent sexual behavior because most investigators have focused on the key proximal determinants of pregnancy--sexual intercourse and contraceptive use--rather than analyzing pregnancy status per se. Lesser pregnancy risk is associated with teens remaining sexually abstinent, postponing onset of intercourse, and having intercourse less often or with fewer partners, as well as by using contraception at first or most recent intercourse and by using contraception consistently over time. Living with a single parent, in a lower SES family, having older sexually active siblings or pregnant/parenting teenage sisters, being a victim of sexual abuse, and residing in disorganized/dangerous neighborhoods all place teens at elevated risk of adolescent pregnancy. Parent-child closeness or connectedness, and parental supervision or regulation of children, in combination with parents values against teen intercourse (or unprotected intercourse), decrease the risk of adolescent pregnancy. Studies about parent-child sexual communication and adolescent pregnancy risk are less conclusive, largely because of methodological complexities.
[Late results of cholelitholytic therapy of patients with cholelithiasis using chenodeoxycholic and ursodeoxycholic acids]. (1991)

Specially selected 78 patients with cholelithiasis received drugs of chenodeoxycholic and ursodeoxycholic acids. Concomitant cardiovascular disorders were in 38 of them. Upon the end of the treatment course (12 months, on the average) the patients were examined and it was found that the stones disappeared in 22 of them. Follow-up evidence is available for 18 of these. Choleliths redeveloped in 9 patients (in 11 months, on the average). Of those who got free of choleliths nobody had relapses for 4.5 years. Various methods used in them to prevent lithogeny (diet, drugs) provided no evidence in favour of one of them. 9 patients with recurrent cholelithiasis after cholelitholytic therapy had no gallstone colic for 4.5 years of the follow-up. Considering the fact that preparations from cheno- and ursodeoxycholic acids are effective in only part of the patients, they seem preferable in patients with concomitant disorders (cardiovascular, etc.) to avoid a high operative risk.
Randomized Comparison of Coronary Stenting With Balloon Angioplasty in Selected Patients With Acute Myocardial Infarction (1998)

In selected patients with acute myocardial infarction, primary stenting can be applied safely and effectively, resulting in a lower incidence of recurrent infarction and a significant reduction in the need for subsequent target-vessel revascularization compared with balloon angioplasty.
The Role of Yeasts in Grape Flavor Development during Fermentation: The Example of Sauvignon blanc (2006)

The development of the aromas of certain grapes varieties during fermentation has not been greatly investigated in enology until now. Recent works on sulfur compounds that participate in the aroma of Sauvignon blanc wines offer an example of grape flavor enhancement by yeasts. Several very odorous volatile thiols have been identified as constituents of the particular aroma of Sauvignon blanc wines: 4-mercapto-4-methylpentan-2-one (4MMP), 4-mercapto-4-methylpentan-2-ol, 3-mercaptohexanol, 3-mercaptohexyl acetate. These different thiols are practically absent in grapes or musts. They appear in wines during the alcoholic fermentation. This increase in varietal flavor due to yeast metabolism can be explained by the degradation of <i>S</i>-cysteine conjugates in the grape, leading to the formation of corresponding volatile thiols. The ability of <i>Saccharomyces cerevisiae</i> strains to augment Sauvignon blanc aromas related to these sulfur-containing aroma compounds is variable. The same Sauvignon must fermented by pure cultures of different yeast strains results in wines with different levels of volatile sulfur aromas. Certain yeast strains (EG8, VL3c) which winemakers have empirically noted produce Sauvignon wines with pronounced varietal character, release the largest quantities of 4MMP. The differences in behavior between <i>S. cerevisiae</i> strains also appears during the fermentation of model mediums added with <i>S</i>-4-(4-methylpentan-2-one)-l-cysteine. Comparing the <i>S. cerevisiae</i> strains commonly used in winemaking, certain wild varieties of <i>Saccharomyces bayanus</i> have been proved particularly suited to freeing the Sauvignon sulfur aromas. Such strains have been isolated in spontaneous fermentation in Sancerre. Natural hybrids between <i>S. cerevisiae</i> and <i>S. bayanus</i> var. <i>uvarum</i> have also been found. They may also be obtained in the laboratory by breeding. The interest in the interspecific hybrids for the vinification of certain grape varieties must be examined.
Efficacy and safety of Shengmai injection as an adjunctive therapy on sepsis (2022)

CRD42021245247.