gebhart/patrepeval huggingface dataset:
A Chlorin-Based Nanoscale Metal–Organic Framework for Photodynamic Therapy of Colon Cancers (2015)

We report here the rational design of the first chlorin-based nanoscale metal-organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient (1)O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.
Excitation of a Magnetic Multilayer by an Electric Current (1998)

We describe variations in the resistance of $\mathrm{Co}/\mathrm{Cu}$ multilayers, induced by means of a high current density $\ensuremath{\approx}{10}^{8}\mathrm{A}/{\mathrm{cm}}^{2}$ injected into the multilayer through a point contact. We propose that the observed resistance changes are due to excitations of zero-wave-number spin waves in the magnetic layers. As predicted, such current-driven excitation of a magnetic multilayer occurs for only one direction of current flow and has a current threshold which increases linearly with the applied magnetic field.
Suspension Culture of Mammalian Cells Using Thermosensitive Microcarrier that Allows Cell Detachment without Proteolytic Enzyme Treatment (2010)

Microcarriers are used to expand anchorage-dependent cells in large-scale suspension bioreactors. Proteolytic enzyme treatment is necessary to detach cells cultured on microcarriers for cell harvest or scale-up, but the enzyme treatment damages the cells and extracellular matrices and complicates the culture process. Here, we fabricated thermosensitive microcarriers from which cells can be detached by temperature change without proteolytic enzyme treatment. A thermosensitive polymer, poly-N-isopropylacrylamide (pNIPAAm), was incorporated on the surface of Cytodex-3® microcarriers. pNIPAAm-grafted microcarriers allowed human bone marrow-derived mesenchymal stem cells (hBMMSCs) to adhere, spread, and grow successfully on the microcarriers as nongrafted microcarriers did. By dropping temperature below 32°C, more than 82.5% of hBMMSCs were detached from pNIPAAm-grafted microcarriers. The trypsin treatment for cell detachment induced apoptosis and death of some of the detached cells, but cell detachment from pNIPAAm-grafted microcarriers by temperature change significantly reduced the apoptosis and cell death. pNIPAAm-grafted microcarriers can significantly reduce cell extracellular matrix damage in the cell detachment process and simplify the cell detachment process by avoiding proteolytic enzyme treatment. pNIPAAm-grafted microcarriers would be valuable to a variety of potential fields demanding a large amount of cells without cell damage, such as cell therapy, tissue engineering, and other biological and clinical applications.
Role of NFkappaB in the mortality of sepsis. (1997)

Binding activity for nuclear factor kappa B (NFkappaB) consensus probes was studied in nuclear extracts from peripheral blood mononuclear cells of 15 septic patients (10 surviving and 5 not surviving). Nonsurvivors could be distinguished from survivors by an increase in NFkappaB binding activity during the observation period (P < 0.001). The increase in NFkappaB binding activity was comparable to the APACHE-II score as a predictor of outcome. Intravenous somatic gene transfer with an expression plasmid coding for IkappaBalpha was used to investigate the role of members of the NFkappaB family in a mouse model of endotoxemia. In this model, increased NFkappaB binding activity was present after injection of LPS. Intravenous somatic gene transfer with IkappaBalpha given before LPS attenuated renal NFkappaB binding activity and increased survival. Endothelial cells and monocytes/macrophages were the major target cells for somatic gene transfer, transfected with an average transfection efficiency of 20-35%. Tissue factor, a gene under regulatory control of NFkappaB, was induced by LPS. Somatic gene transfer with a reporter plasmid containing the functional tissue factor promoter demonstrated NFkappaB-dependent stimulation by LPS. Intravenous somatic gene transfer with IkappaBalpha reduced LPS-induced renal tissue factor expression, activation of the plasmatic coagulation system (decrease of thrombin-antithrombin III complexes) and renal fibrin/fibrinogen deposition. Somatic gene transfer with an expression plasmid with tissue factor cDNA in the antisense direction (in contrast to sense or vector alone) also increased survival. Furthermore, antisense tissue factor decreased renal tissue factor expression and the activation of the plasmatic coagulation system.
GraphTrail (2012)

Exploring large network datasets, such as scientific collaboration networks, is challenging because they often contain a large number of nodes and edges in several types and with multiple attributes. Analyses of such networks are often long and complex, and may require several sessions by multiple users. Therefore, it is often difficult for users to recall their own exploration history or share it with others. We introduce GraphTrail, an interactive visualization for analyzing networks through exploration of node and edge aggregates that captures users' interactions and integrates this history directly in the exploration workspace. To facilitate large network analysis, GraphTrail integrates aggregation with familiar charts, drag-and-drop interaction on a canvas, and a novel pivoting mechanism for transitioning between aggregates. Through a three-month field study with a team of archeologists and a qualitative lab study with ten users, we demonstrate the effectiveness of our design and the benefits of integrated exploration history, including analysis comprehension, insight discovery, and exploration recall.
Activity‐dependent gene regulation in conditionally‐immortalized muscle precursor cell lines (2004)

Skeletal muscle contractile activity has been implicated in many aspects of muscle cell differentiation and maturation. Much of the research in this area has depended upon costly and labor-intensive cultures of isolated primary muscle cells because widely available immortalized muscle cell lines often do not display a high level of either spontaneous or stimulated contractile activity. We sought to develop conditionally-immortalized skeletal muscle cell lines that would provide a source of myofibers that exhibit robust spontaneous contractile activity similar to primary muscle cultures. Using a tetracycline-regulated retroviral vector expressing a temperature-sensitive T-antigen to infect primary myoblasts, we isolated individual clonal muscle precursor cell lines that have characteristics of activated satellite cells during growth and rapidly differentiate into mature myotubes with spontaneous contractile activity after culture in non-transformation-permissive conditions. Comparison of these cell lines (known as rat myoblast-like tetracycline (RMT) cell lines) to primary cell cultures revealed that they share a wide variety of morphological, physiological, and biochemical characteristics. Most importantly, the time-course and extent of activity-dependent gene regulation observed in primary cell culture for all genes tested, including subunits of the nicotinic acetylcholine receptor (nAChR), muscle specific kinase (MuSK), and myogenin, is reproduced in RMT lines. These immortalized cell lines are a useful alternative to primary cultures for studying muscle differentiation and molecular and physiological aspects of electrical activity in muscle fibers.
Mitigating Risk of Data Loss in Preservation Environments (2005)

Preservation environments manage digital records for time periods that are much longer than that of a single vendor product. A primary requirement is the preservation of the authenticity and integrity of the digital records while simultaneously minimizing the cost of long-term storage, as the data is migrated onto successive generations of technology. The emergence of low-cost storage hardware has made it possible to implement innovative software systems that minimize risk of data loss and preserve authenticity and integrity. This paper describes software mechanisms in use in current persistent archives and presents an example based upon the NARA research prototype persistent archive.
27.7 A 30.5mm3 fully packaged implantable device with duplex ultrasonic data and power links achieving 95kb/s with <10−4 BER at 8.5cm depth (2017)

The next generation of implantable medical devices focuses on minimally invasive miniaturized solutions that operate reliably at large depths, provide duplex communication for closed-loop therapies, and enable multi-access for a network of implants to gather information or provide systemic interventions. Using ultrasound (US), power and data can be efficiently transferred through the body as its wavelength at MHz is comparable to a mm-sized receiver, resulting in improved focusing, coupling, and acoustic-to-electrical conversion efficiency. Furthermore, thanks to the low propagation loss (∼1dB/cm/MHz) and 7.2mW/mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> safety limit, several mW of power is obtainable at the receiver, enabling high-power, complicated functionalities.
A mesoionic bis(Py-tzNHC) palladium(ii) complex catalyses “green” Sonogashira reaction through an unprecedented mechanism (2015)

A novel bis(pyridyl-functionalized 1,2,3-triazol-5-ylidene)-palladium(II) complex [Pd(Py-tzNHC)2](2+) catalyses the copper-, amine-, phosphine-, and additive-free aerobic Sonogashira alkynylation of (hetero)aryl bromides in water as the only reaction solvent. The catalysis proceeds along two connected Pd-cycles with homogeneous bis-carbene Pd(0) and Pd(II) species, as demonstrated by electrospray ionization mass spectrometry.
Neuroretinitis: Review of the Literature and New Observations (2011)

Neuroretinitis (NR) is an inflammatory disorder characterized by optic disc edema and subsequent formation of a macular star figure. The underlying pathophysiology involves increased permeability of disc vasculature, but the etiology is not fully defined. In some cases, NR is probably due to an infectious process involving the disc; in others, a postviral or autoimmune mechanism is more likely. Cases can be divided into those in which a specific infectious agent has been identified, those considered idiopathic, and those with recurrent attacks. Some reports have not distinguished among these subgroups, and it is unclear if their clinical features vary. We reviewed the literature and our own patients looking particularly at features that might better distinguish these subtypes. Features common to all 3 groups included age, absence of pain, and fundus appearance. Preceding systemic symptoms were more common in patients with cat scratch disease (CSD) and uncommon in those with recurrence. The pattern and magnitude of visual field loss differed, more commonly confined to the central field in CSD cases and more severe in recurrent cases. Recovery of visual acuity and field was less substantial in recurrent cases even after the initial episode. MRI was usually normal in all 3 groups. Enhancement confined to the optic disc was found in all 3 groups, but enhancement of the retrobulbar optic nerve was seen only in recurrent cases. Findings that are strongly suggestive of CSD include very young age, preceding systemic symptoms, and poor visual acuity but with a small or absent relative afferent pupil defect (RAPD). In contrast, the following are suggestive of idiopathic NR with a high risk of recurrence: absence of systemic symptoms, visual field defect outside the central field, preserved visual acuity with a large RAPD, and poor recovery of vision. Decisions regarding evaluation and treatment should be made with these features in mind.
Speed-up of Aho-Corasick pattern matching machines by rearranging states (2001)

This article describes speed-up of string pattern matching by rearranging states in Aho-Corasick pattern matching machine, which is a kind of afinite automaton. We realized speed-up of string pattern matching using data compression. Although we obtain higher compression ratio using a finite state model, it doesn't lead speed-up of string pattern matching. Because the pattern matching machine becomes very large, when compression codes are complex. Random Access Memory (RAM) are scattered with states used frequently Such states are close to the initial state of pattern matching machine. We rearrange states so as to collecting states used frequently for CPU cache eficiency. We renumber states in breadth-first order. In experiments, the elapsed time is reduced to about 55% in case of a compressed English text.
Advanced Batteries for Electric Vehicles: An Assessment of Performance, Cost, and Availability (2000)

This report documents the findings of a study undertaken to investigate batteries for use in electric vehicles. Batteries studied include lead-acid batteries, nickel-metal hydride batteries, lithium-ion electric vehicle batteries, and lithium-metal polymer electric vehicle batteries. Battery cost, performance, operating life, charging efficiency and availability were evaluated for each battery type.
Resistance to tamoxifen‐induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer (2001)

Overexpression of Her2/neu is implicated in the development of resistance to the antiestrogen tamoxifen (TAM) that exerts its inhibitory effect through interaction with estrogen receptor (ER). Whereas Her2/neu and ER are believed to be important cell survival/death factors in human breast cancer cells, if and how they interact to confer resistance to hormone therapy is not known. This prompted us to investigate whether modulation of the effect of TAM occurs via the Her2/neu pathway and whether targeting the interaction between the Her2/neu pathway and the ER pathway is beneficial. There are 2 forms of ER that are localized to the cell membrane and to the nucleus. For the first time, we found that Her2/neu directly interacts with ER at the cell membrane. We then investigated the role of Her2/neu overexpression in the regulation of the cell membrane ER pathway in TAM-resistant breast cancer cells and the nature of this interaction in apoptotic signaling. Relief of TAM resistance was associated with Her2/neu downregulation and ER upregulation. TAM-induced apoptosis occurred immediately after dissociation of Her2/neu from cell membrane ER. These results demonstrate a novel mechanism by which Her2/neu regulates the cell membrane ER-coupled apoptosis and the possible involvement of the Her2/neu in TAM resistance of breast cancer cells. Moreover, the antiproliferative activity of TAM should rely on the integration between the signal transduction from the cell membrane ER and the gene regulation by the nuclear ER. Coordinated modulation on the cell membrane ER/Her2/neu pathway and the nuclear ER/RAR pathway may provide a new approach for treatment of ER-positive, Her2/neu overexpressing breast cancer.
Distributed Blinding for ElGamal Re-encryption (2004)

A protocol is given that allows a set of n servers to cooperate and produce an ElGamal ciphertext encrypted under one key from an ElGamal ciphertext encrypted under another, but without plaintext ever becoming available. The protocol is resilient to 1)/3# of the servers being compromised and requires no assumptions about execution speeds or message delivery delays. Two new building blocks employed---a distributed blinding protocol and verifiable dual encryption proofs---could have uses beyond re-encryption protocols.
Color Centers in KI:T1 X-Rayed at Low Temperatures (1959)

The optical properties of the phosphor KI:Tl have been studied after x-raying at 5 or 78°K. The interactions among the several simultaneously produced centers have been studied by following and correlating changes in luminescent intensity and optical absorption spectra as the crystal is warmed, and an explanation of these effects is offered in terms of retrapping and recombination. Perturbation bands due to the modification of the energy levels of the luminescent center as a result of the interaction with a color center are observed. The major centers produced in the more heavily doped crystals by brief irradiation at low temperatures do not involve vacancies and are identified as an electron center associated with Tl, I2—, and V centers near Tl+. The optical absorption spectrum of I2— consists of bands at 404 and 800 mμ. (The absorption of Br2— in KBr:Tl incidentally has also been identified.) On the basis of certain similarities in luminescence properties, essentially similar effects are proposed for ultraviolet as for x-ray excitation.
Toward an Evidence-Based, Operational Definition of Treatment-Resistant Depression (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. (1989)

Endothelium is an important target of tumor necrosis factor/cachectin (TNF), a central mediator of the host response in endotoxemia and Gram-negative sepsis. In this report, TNF is shown to increase the permeability of endothelial cell monolayers to macromolecules and lower molecular weight solutes by a mechanism involving a pertussis toxin-sensitive regulatory G protein. Within 1-3 h of exposure to TNF (5 nM), changes in cell shape/cytoskeleton occurred that led to disruption of monolayer continuity with the formation of intercellular gaps. Correlated with these structural changes was an increase in endothelial permeability to macromolecular and lower molecular weight tracers; time-dependent, reversible increases in passage of these tracers, evident by 1-3 h, were observed after addition of TNF to cultures. Perturbation of barrier function by TNF also depended on the dose of TNF added being half-maximal by approximately 0.4 nM. Only a brief exposure (15 min) of TNF to endothelium was required to induce an increase in permeability, and this was not prevented by the presence of cycloheximide or actinomycin D. Preincubation of monolayers with pertussis toxin blocked in parallel TNF-induced increased passage of solutes and cell shape/cytoskeletal perturbation, indicating the close correlation between these changes in endothelial cell function. In contrast, pertussis toxin did not alter TNF-induced modulation of two endothelial cell coagulant properties. These data provide evidence for two intracellular pathways of TNF action that are distinguishable by pertussis toxin and provide insight into a mechanism underlying loss of solute from the intravascular space mediated by TNF: alteration in endothelial cell barrier function.
TRIPHENYLMETHYL. XXXIII. QUINOIDATION IN THE TRIARYLMETHYLS1 (1923)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTRIPHENYLMETHYL. XXXIII. QUINOIDATION IN THE TRIARYLMETHYLS1M. Gomberg and F. F. BlickeCite this: J. Am. Chem. Soc. 1923, 45, 7, 1765–1779Publication Date (Print):July 1, 1923Publication History Published online1 May 2002Published inissue 1 July 1923https://pubs.acs.org/doi/10.1021/ja01660a029https://doi.org/10.1021/ja01660a029research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients. (1990)

Serum ultrafiltrates (SUF) from human patients with different types of cancer contain a blocking factor (BF) that inhibits the cytolytic activity of human tumor necrosis factor alpha (TNF-alpha) in vitro. BF is a protein with a molecular mass of 28 kDa on reducing sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS/PAGE). The active material was purified to homogeneity by a combination of affinity chromatography, PAGE, and high-pressure liquid chromatography. Amino acid sequence analysis revealed that BF is derived from the membrane TNF receptor. Purified BF blocks the lytic activity of recombinant human and mouse TNF-alpha and recombinant human lymphotoxin on murine L929 cells in vitro. However, BF inhibits the lytic activity of TNF-alpha more effectively than it does that of lymphotoxin. The BF also inhibits the necrotizing activity of recombinant human TNF-alpha when coinjected into established cutaneous Meth A tumors in BALB/c mice. The BF may have an important role in (i) the regulation and control of TNF-alpha and lymphotoxin activity in cancer patients, (ii) interaction between the tumor and the host antitumor mechanisms, and (iii) use of systemically administered TNF-alpha in clinical trials with human cancer patients.