gebhart/patrepeval huggingface dataset:
A Comparison of the Effects of Computer and Manual Reminders on Compliance with a Mental Health Clinical Practice Guideline (2000)

In an outpatient mental health clinic, computer reminders were shown to be superior to manual reminders in improving adherence to a clinical practice guideline for depression.
Isolation and purification of ILS, an interleukin 1 inhibitor produced by human gingival epithelial cells. (1987)

Recent studies have described the presence of an interleukin 1 (IL-1) inhibitor (ILS) in supernatants from human gingival organ cultures. This report describes the isolation and purification of ILS. ILS was produced in serum-free medium and purified to apparent homogeneity by ion exchange chromatography and high pressure liquid chromatography. IL-1 and ILS eluted as discrete proteins using this system, with ILS appearing as a single protein band of 97,400 molecular weight on SDS-PAGE. ILS inhibited the effects of both murine IL-1 and IL-2 on thymocyte proliferation, and was heat resistant, moderately resistant to freeze-thawing and stable for 2 years at 0-4 degrees C or -20 degrees C. Production of ILS by gingival epithelial cell cultures was not affected by depletion of Langerhans cells, implying that ILS is primarily a keratinocyte product.
Instrumenting Java Bytecode to Replay Execution Traces of Multithreaded Programs (2003)

Replay of program executions, that lead to a failure, can help developers to find soft-ware faults. While replay of deterministic executions of sequential programs can be easily achieved with existing debuggers, little support exists for deterministic replay of a multi-threaded program. In Java, scheduling of threads depends on the algorithm implemented in the underlying virtual machine. A multi-threaded program is executed according to one of many possible schedules. In this thesis a conceptual model to replay a specific thread schedule of a multi-threaded Java program is developed. A generic representation of an execution trace that contains all information for a deterministic replay of a given thread schedule was devised. Determinis-tic replay is achieved by modifying the bytecode of the original program such that only one thread at a time may runs according to the specified schedule. This allows deterministic replay on any virtual machine that conforms to the specification by Sun. The model is implemented in jreplay, a software utility to enforce a given thread schedule
Ganglioside mimicry and peripheral nerve disease (2007)

Four criteria must be satisfied to conclude that a given microorganism causes Guillain-Barré (GBS) or Fisher (FS) syndrome associated with anti-ganglioside antibodies: (1) an epidemiological association between the infecting microbe and GBS or FS; (2) isolation in the acute progressive phase of illness of that microorganism from GBS or FS patients with associated anti-ganglioside IgG antibodies; (3) identification of a microbial ganglioside mimic; and (4) a GBS or FS with associated anti-ganglioside antibodies model produced by sensitization with the microbe itself or its component, as well as with ganglioside. Campylobacter jejuni is a definitive causative microorganism of acute motor axonal neuropathy and may cause FS and related conditions. Haemophilus influenzae and Mycoplasma pneumoniae are possible causative microorganisms of acute motor axonal neuropathy or FS. Acute and chronic inflammatory demyelinating polyneuropathies may be produced by mechanisms other than ganglioside mimicry.
Enhancement Patterns of Hepatocellular Carcinoma at Contrast-enhanced US: Comparison with Histologic Differentiation (2007)

Moderately differentiated HCC generally shows classic enhancement features, while well- and poorly differentiated tumors account for most atypical variations. Extended observation in the portal phase is important as late washout occurs with slightly more frequency than washout in the conventionally defined portal venous phase.
STEREOELECTRONIC EFFECTS IN THE HYDROLYSIS OF PHOSPHONIUM IONS FROM ACYCLIC AND BICYCLIC PHOSPHOROTHIONATES (1990)

Abstract The alkaline hydrolysis of the bicyclic phosphonium ion 1-methyl-3,5,8-trioxabicyclo-[2,2,2]octane-4-methylthiophosphonium ion 1 proceeds mainly with P-O bond cleavage as shown by hydrolysis in 18O labeled water to form the cyclic epimers cis- and trans-2-methylmercapto-2-oxo-5-hydroxymethyl- l,3,2-dioxaphosphorinane (2/3) in addition to the bicyclic phosphate, l-methyl-4-phospha-3,5,8-trioxabicyclo-(2,2,2]octane-4-oxide, 4. The trans epimer 3 is formed after pseudorotation of the triagonal bipyramid (tbp) intermediate and is the predominant initial product. This could be explained by deprotonation of the initial neutral tbp intermediate 5 followed by fast pseudorotation to give the more stable anionic tbp 5′ in which the negatively charged oxygen is placed in the equatorial position of the intermediate. In contrast, the acyclic analogue triethoxy(methylthio)phosphonium ion undergoes alkaline hydrolysis with 100% P-S bond cleavage. It is very unusual to observe P-O bond cleavage competitive with P-S bond cleavage as we have demonstrated for the hydrolysis of the bicyclic thiophosphonium ion, 1. These results are supportive of the stereoelectronic effect hypothesis.
Transgenic rescue implicates β2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice (2001)

Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic beta cells. Linkage studies have shown that type 1 diabetes in NOD mice is a polygenic disease involving more than 15 chromosomal susceptibility regions. Despite extensive investigation, the identification of individual susceptibility genes either within or outside the major histocompatibility complex region has proven problematic because of the limitations of linkage analysis. In this paper, we provide evidence implicating a single diabetes susceptibility gene, which lies outside the major histocompatibility complex region. Using allelic reconstitution by transgenic rescue, we show that NOD mice expressing the beta(2) microglobulin (beta(2)M)(a) allele develop diabetes, whereas NOD mice expressing a murine beta(2)M(b) or human allele are protected. The murine beta(2)M(a) allele differs from the beta(2)M(b) allele only at a single amino acid. Mechanistic studies indicate that the absence of the NOD beta(2)M(a) isoform on nonhematopoietic cells inhibits the development or activation of diabetogenic T cells.
Implementing the Viterbi algorithm (1995)

The Viterbi algorithm, an application of dynamic programming, is widely used for estimation and detection problems in digital communications and signal processing. It is used to detect signals in communication channels with memory, and to decode sequential error-control codes that are used to enhance the performance of digital communication systems. The Viterbi algorithm is also used in speech and character recognition tasks where the speech signals or characters are modeled by hidden Markov models. The article explains the basics of the Viterbi algorithm as applied to systems in digital communication systems, and speech and character recognition. It also focuses on the operations and the practical memory requirements to implement the Viterbi algorithm in real-time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Urinary fibronectin: potential as a biomarker in prostatic cancer. (1980)

The levels of fibronectin in urine from patients with prostatic cancer, from patients with benign urologic disease, and from healthy control individuals were determined by the use of a gelatin affinity chromatography procedure. The assay does not seem to give false positive results, inasmuch as evaluation of 16 patients with benign urologic disease showed urinary fibronectin levels in the same range as those found in healthy controls. For a single determination, the levels in 42 per cent of prostatic cancer patients were elevated above control levels; when prostatic cancer patients were evaluated sequentially, the determination of urinary fibronectin levels over three sampling times approached a 100 per cent correlation with presence of disease. Inasmuch as levels of urinary fibronectin episodically elevate in patients with prostatic carcinoma, the differential frequency and magnitude of urinary fibronectin elevations may be useful markers to assess tumor aggressiveness and to monitor the impact of a therapeutic modality.
Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial (2013)

The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B and E) was previously shown to have a 31.2% efficacy rate. Plasma specimens from vaccine and placebo recipients were used in an extensive set of assays to identify correlates of HIV-1 infection risk. Of six primary variables that were studied, only one displayed a significant inverse correlation with risk of infection: the antibody (Ab) response to a fusion protein containing the V1 and V2 regions of gp120 (gp70-V1V2). This finding prompted a thorough examination of the results generated with the complete panel of 13 assays measuring various V2 Abs in the stored plasma used in the initial pilot studies and those used in the subsequent case-control study. The studies revealed that the ALVAC-HIV/AIDSVAX vaccine induced V2-specific Abs that cross-react with multiple HIV-1 subgroups and recognize both conformational and linear epitopes. The conformational epitope was present on gp70-V1V2, while the predominant linear V2 epitope mapped to residues 165-178, immediately N-terminal to the putative α4β7 binding motif in the mid-loop region of V2. Odds ratios (ORs) were calculated to compare the risk of infection with data from 12 V2 assays, and in 11 of these, the ORs were ≤1, reaching statistical significance for two of the variables: Ab responses to gp70-V1V2 and to overlapping V2 linear peptides. It remains to be determined whether anti-V2 Ab responses were directly responsible for the reduced infection rate in RV144 and whether anti-V2 Abs will prove to be important with other candidate HIV vaccines that show efficacy, however, the results support continued dissection of Ab responses to the V2 region which may illuminate mechanisms of protection from HIV-1 infection and may facilitate the development of an effective HIV-1 vaccine.
Positioning protein molecules on surfaces: A nanoengineering approach to supramolecular chemistry (2002)

We discuss a nanoengineering approach for supramolecular chemistry and self assembly. The collective properties and biofunctionalities of molecular ensembles depend not only on individual molecular building blocks but also on organization at the molecular or nanoscopic level. Complementary to "bottom-up" approaches, which construct supramolecular ensembles by the design and synthesis of functionalized small molecular units or large molecular motifs, nanofabrication explores whether individual units, such as small molecular ligands, or large molecules, such as proteins, can be positioned with nanometer precision. The separation and local environment can be engineered to control subsequent intermolecular interactions. Feature sizes as small as 2 x 4 nm(2) (32 alkanethiol molecules) are produced. Proteins may be aligned along a 10-nm-wide line or within two-dimensional islands of desired geometry. These high-resolution engineering and imaging studies provide new and molecular-level insight into supramolecular chemistry and self-assembly processes in bioscience that are otherwise unobtainable, e.g., the influence of size, separation, orientation, and local environment of reaction sites. This nanofabrication methodology also offers a new strategy in construction of two- and three-dimensional supramolecular structures for cell, virus, and bacterial adhesion, as well as biomaterial and biodevice engineering.
MICROPHONE ARRAY POST-PROCESSOR USING INSTANTANEOUS DIRECTION OF ARRIVAL (2006)

In this paper we describe a novel algorithm for postprocessing a microphone array’s beamformer output to achieve better spatial filtering under noise and reverberation. For each audio frame and frequency bin the algorithm estimates the spatial probability for sound source presence and applies a spatio-temporal filter towards the look-up direction. It is implemented as a real-time post-processor after a timeinvariant beamformer and it substantially improves the directivity of the microphone array. The algorithm is CPU efficient and adapts quickly when the listening direction changes. It was evaluated with a linear four element microphone array. The directivity index improvement is up to 8 dB, the suppression of a jammer 40 ° from the sound source is up to 17 dB. 1.
Rolling-circle replication of bacterial plasmids (1997)

Many bacterial plasmids replicate by a rolling-circle (RC) mechanism. Their replication properties have many similarities to as well as significant differences from those of single-stranded DNA (ssDNA) coliphages, which also replicate by an RC mechanism. Studies on a large number of RC plasmids have revealed that they fall into several families based on homology in their initiator proteins and leading-strand origins. The leading-strand origins contain distinct sequences that are required for binding and nicking by the Rep proteins. Leading-strand origins also contain domains that are required for the initiation and termination of replication. RC plasmids generate ssDNA intermediates during replication, since their lagging-strand synthesis does not usually initiate until the leading strand has been almost fully synthesized. The leading- and lagging-strand origins are distinct, and the displaced leading-strand DNA is converted to the double-stranded form by using solely the host proteins. The Rep proteins encoded by RC plasmids contain specific domains that are involved in their origin binding and nicking activities. The replication and copy number of RC plasmids, in general, are regulated at the level of synthesis of their Rep proteins, which are usually rate limiting for replication. Some RC Rep proteins are known to be inactivated after supporting one round of replication. A number of in vitro replication systems have been developed for RC plasmids and have provided insight into the mechanism of plasmid RC replication.
Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy (2009)

The phenanthroindolizidine and phenanthroquinolizidine alkaloids, typified by tylophorine and cryptopleurine, are a family of plant-derived small molecules with significant therapeutic potential. The plant extracts have been used in herbal medicine and the isolated compounds have displayed a range of promising therapeutic activity such as anti-ameobicidal, anti-viral, anti-inflammatory and anti-cancer activity. Despite their therapeutic protential, no compounds in this class have fully passed clinical trials. Drawbacks include low in vivo anti-cancer activity, central nervous system toxicity and low natural availability. A number of biological effects of these compounds, such as protein and nucleic acid synthesis suppression, have been identified, but the specific biomolecular targets have not yet been identified. Significant effort has been expended in the synthesis and structure-activity-relationship (SAR) studies of these compounds with the hope that a new drug will emerge. This review will highlight important contributions to the isolation, synthesis, SAR and mechanism of action of the phenanthroindolizidine and pheanthroquinolizidine alkaloids.
Post-prandial hyperglycemia. post-prandial hyperglycemia and diabetes. (2000)

Post-prandial hyperglycemia (PPHG) is an independent risk factor for the development of macrovascular complications. It is now recognized that normalizing post-prandial blood glucose is more difficult than normalizing fasting glucose. Many factors affect the post-prandial blood glucose excursion. The glycemic index of the meal depends on the nature of the ingested food and starch composition. Gastric emptying is influenced by various factors including gut hormones such as GIP and GLP1, which potentiate insulin secretion, especially in its acute first phase, now referred to as an incretin effect. They also modulate glucagon secretion. Post-prandial hyperglycemia is limited by uptake of glucose by the liver and by inhibition of endogenous glucose production in this organ. In healthy controls, hepatic glucose production is halved after a meal, whereas in glucose-intolerant individuals and type 2 diabetics this inhibition is impaired (20-30% versus 50%). The persistence of endogenous glucose production during the post-prandial phase appears to be the main culprit in the PPHG. This reduced decrease in endogenous glucose in glucose intolerant and type 2 diabetic patients depends not only on the first acute phase of insulin secretion, but above all on the non-suppressed glucagon level during the post-prandial phase. Glucagon levels fall in healthy control subjects during the post-prandial phase. Although peripheral glucose uptake by insulin-dependent tissues is altered in type 2 diabetic patients, it does not appear to be the major cause of the PPHG as there are patients with insulin resistance but without post-prandial hyperglycemia.
Commonsense Preparedness for Uncommon Adversities: Lessons from Facing COVID-19 in Mexico, from a Human Ecology Perspective (2021)

In 2020, while living through unprecedented health outcomes from the COVID-19 epidemic in Mexico, a human ecology perspective provides us with an unconventional way to analyze the role of the mediate effects of Mexican nutritional impacts and their prevalence in COVID-19-related mortality.According to official data, by the end of September 2020, mortality by COVID-19 surpassed 76,000 confirmed deaths across Mexico; by August 2020, COVID-19 mortality was lower in the center of the country where hospital infrastructure and human resources such as specialized health personnel are concentrated.This regional difference corresponds to the serious socioeconomic inequality characteristic of Mexican society, where southeastern states are poorer.A human ecology perspective allows us to identify and discuss similarities and discrepancies between the prevalence of obesity distribution and COVID-19 lethality across Mexico, and ultimately to provide our thoughts on the preparedness of Mexican society, with epidemiological evidence and a preventive, transdisciplinary scope.
Diagnosis of Human Parvovirus B19 Infections by Polymerase Chain Reaction (1992)

The polymerase chain reaction (PCR) was used for detecting parvovirus B19 DNA in clinical specimens. A pair of oligonucleotide primers spanning the PstI-fragment of the B19 virus genome was used for PCR, and a PCR product of 727 bp was amplified. B19 virus DNA was detected in all sera (n = 26) of individuals in the incubation period and acute phase of infection. PCR was useful for detecting viral B19 DNA in amniotic fluid and fetal blood of hydropic fetuses, confirming fetal B19 virus infection.
Las decisiones y la emboscada del tiempo (2018)

Hacemos una propuesta teorica para explicar las decisiones de un agente vivo, con cerebro, ante incertidumbre temporal y en contextos de mercado. Con avances de las neurociencias, la economia y la filosofia de la ciencia, articularemos una perspectiva panoramica sobre las decisiones que orientan la conducta hacia fines, llamadas decisiones con Racionalidad Evaluativa. Incluye las limitaciones disciplinares sin profundizar en sus especializaciones y propone la temporalidad como hilo conductor de las operaciones decisorias y sus modelos mentales. Para las ciencias, la racionalidad es impredecible pues aun no definen con exactitud cuales son los detonadores de la conducta y no encuentran ni en las necesidades corporales, ni en el contexto, ni en los valores socioculturales, una perspectiva de comprension interdisciplinaria sobre el decidir. Propondremos algunas operaciones mentales que orientan al futuro y a la temporalidad para comprender la racionalidad decisoria. Responderemos desde diversas disciplinas, la pregunta sobre cuales operaciones mentales intervienen para alcanzar un proposito en el futuro. Realizaremos una aproximacion teorica con aportaciones de esas disciplinas y propondremos que los principios de temporalidad y simultaneidad que caracterizan a las operaciones mentales y son inherentes a la racionalidad, permiten al agente decidir y resolver su incertidumbre de futuro ante cada contexto.© 2017 Universidad Nacional Autonoma de Mexico, Asociacion Mexicana de Comportamiento y Salud. Este es un articulo Open Access bajo la licencia CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).
대학부설 평생교육원 활성화 사업 성과분석 연구 (2010)

이 연구에서는 대학부설 평생교육원 활성화 사업 중 `학습비 지원사업`을 중심으로 이 사업의 2차년도인 2009년의 성과를 분석하고자 하였다. 이 연구의 목적을 달성하기 위해서, 유현숙 외5인(2006)이 제시한 성과분석 준거인 `효과성`에 근거하여 참여 프로그램 관련 변인들에 대한 학습자들의 반응을 통해 학습비 지원사업의 성과를 분석하고자 하였다. 총...
[The study on skin wound healing promoting action of sodium usnic acid]. (2005)

Sodium usnic acid can accelerate skin wound healing, the effects was not by stimulating proliferation of fibroblasts.
Disadaptive disorders in women: allopregnanolone, a sensitive steroid (2004)

Allopregnanolone, a neurosteroid acting as a potent anxiolytic agonist of the gamma-aminobutyric acid A receptor, has been shown in animal models to modify its concentrations at central and peripheral levels according to the estrous cycle. Moreover, it modulates behavioral and biochemical responses to acute and chronic stress, anxiety, depression, aggressiveness, convulsions, anesthesia, sleep, memory, pain and feeding. These observations suggest that fluctuations of allopregnanolone might be involved in the development, course and prognosis of some mental disorders in humans. This has been hypothesized for depressive disorders, premenstrual dysphoria, anorexia and bulimia nervosa and Alzheimer's disease, where increased, decreased or dysregulated secretion of the main neurosteroids and their metabolites has been observed. Women show a marked gender-related sensitivity to disadaptive disorders. In addition to the well-studied role of sex steroids in modulating mood and behavior, a putative involvement of neurosteroid fluctuations, and in particular of allopregnanolone, has recently been hypothesized. In fact, several paraphysiological events and various disadaptive disorders in women are associated with modifications of circulating levels of this neurosteroid that might associated with a certain vulnerability to an altered adaptation to stressful life events.
SPANBRE: An Efficient Hierarchical Clustering Algorithm for Spatial Data with Neighborhood Relations (2007)

Due to the attributes of the neighbors are always similar or associated to each other, we address the problem of discovering spatial relationships in spatial data through the identification of clusters based on spatial neighborhood relations. We present an efficient clustering algorithm called SPANBRE that generates high quality clusters in O(nlogn) time and in O(n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) message complexity. SPANBRE is kind of agglomerative hierarchical method. By using a sequence data structure, SPANBRE avoids the complex spatial join operation. SPANBRE also execute an optimization strategy for clustering splitting and merging to achieve high clustering quality. The experimental results on traffic flow data sets show that the clustering quality and the algorithm efficiency of SPANBRE are superior to other alternative techniques.