gebhart/patrepeval huggingface dataset:
A convenient reduction of amino acids and their derivatives (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA convenient reduction of amino acids and their derivativesMarc J. McKennon, A. I. Meyers, Karlheinz Drauz, and Michael SchwarmCite this: J. Org. Chem. 1993, 58, 13, 3568–3571Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00065a020https://doi.org/10.1021/jo00065a020research-articleACS PublicationsRequest reuse permissionsArticle Views18550Altmetric-Citations445LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Novel RNA Motif Mediates the Strict Nuclear Localization of a Long Noncoding RNA (2014)

The ubiquitous presence of long noncoding RNAs (lncRNAs) in eukaryotes points to the importance of understanding how their sequences impact function. As many lncRNAs regulate nuclear events and thus must localize to nuclei, we analyzed the sequence requirements for nuclear localization in an intergenic lncRNA named BORG (BMP2-OP1-responsive gene), which is both spliced and polyadenylated but is strictly localized in nuclei. Subcellular localization of BORG was not dependent on the context or level of its expression or decay but rather depended on the sequence of the mature, spliced transcript. Mutational analyses indicated that nuclear localization of BORG was mediated through a novel RNA motif consisting of the pentamer sequence AGCCC with sequence restrictions at positions -8 (T or A) and -3 (G or C) relative to the first nucleotide of the pentamer. Mutation of the motif to a scrambled sequence resulted in complete loss of nuclear localization, while addition of even a single copy of the motif to a cytoplasmically localized RNA was sufficient to impart nuclear localization. Further, the presence of this motif in other cellular RNAs showed a direct correlation with nuclear localization, suggesting that the motif may act as a general nuclear localization signal for cellular RNAs.
Enhanced Environmental Degradation of Plastics (1981)

Abstract Intensive research in the last two decades on the degradation of commercial plastics has led to the development of new methods of degradation and innumerable experimental techniques to characterize the degraded products. During the period 1970–1980, there have been substantial advances in most of the important aspects of polymer degradation including that induced by heat, light, oxygen, high energy radiation, photooxidation, and biological factors; and accounts have been given at various times of the current position in most of these [1–30].
Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles (2016)

Liquid-liquid phase separation of charge- and/or aromatic-enriched intrinsically disordered proteins (IDPs) is critical in the biological function of membraneless organelles. Much of the physics of this recent discovery remains to be elucidated. Here, we present a theory in the random phase approximation to account for electrostatic effects in polyampholyte phase separations, yielding predictions consistent with recent experiments on the IDP Ddx4. The theory is applicable to any charge pattern and thus provides a general analytical framework for studying sequence dependence of IDP phase separation.
New fast algorithms for the estimation of block motion vectors (1993)

Two algorithms for block motion estimation that produce performance similar to that of exhaustive search but with computation reduced by a factor of 8 or 16 are presented. The algorithms are based on motion-field and pixel subsampling. A subsampled motion field is first determined by estimating the motion vectors for a fraction of the blocks. The motion vectors for these blocks are determined by using only a fraction of the pixels at any searched location and by alternating the pixel subsampling patterns with the searched locations. The subsampled motion field is then interpolated so that a motion vector is determined for each block of pixels. The algorithms are more robust than previously proposed fast algorithms and both can easily be combined with a hierarchical search strategy. One of the algorithms is fully compatible with MPEG-I.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chelation of aluminum by combining deferasirox and deferiprone in rats (2011)

The hypothesis that two known chelators deferasirox and deferiprone (L1) might be more efficient as combined treatment than as single therapies in removing aluminum from the body was tested in a new acute rat model. Seven-week-old male Wistar rats received chelators: deferasirox (orally [p.o.]), L1 (p.o.) or deferasirox + L1 as 100 or 200 mg/kg dose half an hour after a single intraperitoneal administration of 6 mg Al/kg body weight in the form of chloride. Serum aluminum concentration, urinary aluminum and iron excretions were determined by graphite furnace atomic absorption spectrometry. Both chelators were effective only at the higher dose level. While deferasirox was more effective than L1 in enhancing urinary aluminum excretion, L1 was more effective than deferasirox in enhancing urinary iron excretion. In the combined treatment group, deferasirox did not increase the L1 effect on aluminum and L1 did not increase the effect of deferasirox on iron elimination. Our results support the usefulness of this animal model for preliminary in vivo testing of aluminum chelators. Urinary values were more useful due to the high variability of serum results.
Recent advances of pore system construction in zeolite-catalyzed chemical industry processes (2015)

The kaleidoscopic applications of zeolite catalysts (zeo-catalysts) in petrochemical processes has been considered as one of the major accomplishments in recent decades. About twenty types of zeolite have been industrially applied so far, and their versatile porous architectures have contributed their most essential features to affect the catalytic efficiency. This review depicts the evolution of pore models in zeolite catalysts accompanied by the increase in industrial and environmental demands. The indispensable roles of modulating pore models are outlined for zeo-catalysts for the enhancement of their catalytic performances in various industrial processes. The zeolites and related industrial processes discussed range from the uni-modal micropore system of zeolite Y (12-ring micropore, 12-R) in fluid catalytic cracking (FCC), zeolite ZSM-5 (10-R) in xylene isomerization and SAPO-34 (8-R) in olefin production to the multi-modal micropore system of MCM-22 (10-R and 12-R pocket) in aromatic alkylation and the hierarchical pores in FCC and catalytic cracking of C4 olefins. The rational construction of pore models, especially hierarchical features, is highlighted with a careful classification from an industrial perspective accompanied by a detailed analysis of the theoretical mechanisms.
Noninvasive monitoring of infection and rejection after lung transplantation (2015)

The survival rate following lung transplantation is among the lowest of all solid-organ transplants, and current diagnostic tests often fail to distinguish between infection and rejection, the two primary posttransplant clinical complications. We describe a diagnostic assay that simultaneously monitors for rejection and infection in lung transplant recipients by sequencing of cell-free DNA (cfDNA) in plasma. We determined that the levels of donor-derived cfDNA directly correlate with the results of invasive tests of rejection (area under the curve 0.9). We also analyzed the nonhuman cfDNA as a hypothesis-free approach to test for infections. Cytomegalovirus is most frequently assayed clinically, and the levels of CMV-derived sequences in cfDNA are consistent with clinical results. We furthermore show that hypothesis-free monitoring for pathogens using cfDNA reveals undiagnosed cases of infection, and that certain infectious pathogens such as human herpesvirus (HHV) 6, HHV-7, and adenovirus, which are not often tested clinically, occur with high frequency in this cohort.
Adhesion and Cytosolic Dye Transfer between Macrophages and Intestinal Epithelial Cells (1998)

Activated macrophages (M phi) found in the intestinal lesions of patients with inflammatory bowel disease (IBD) secrete many inflammatory mediators which can regulate intestinal epithelial cell (IEC) function. However, little is known about direct M phi-IEC interactions. Two potential mechanisms by which cells may interact are through specific receptor-ligand binding of adhesion molecules, such as integrins or cadherins, and by exchange of cytoplasmic substances through transmembraneous channels called gap junctions. We investigated whether M phi could adhere to epithelial cells in culture and form transmembrane communication channels as defined by dye transfer. Primary cultures of murine M phi and a M phi cell line, P388D1, adhered to Mode-K and IEC6, but not CMT-93 IEC. Antibody blocking studies determined that P388D1-Mode-K binding was partially dependent on beta 2 integrin (CD18) function, Mode-K constitutively expressed CD106 (VCAM-1) and cell associated fibronectin, while P388D1 expressed low levels of CD49d/CD29 (VLA4) but blocking antibodies to these surface molecules did not inhibit P388D1-Mode-K adherence. Transfer of calcein dye from M phi to IEC was quantitated by flow cytometry and was dependent on M phi-IEC adhesion. Dye transfer was concentration dependent in that the fluorescence intensity of Mode-K was proportional to the number of adherent P388D1 cells as well as the dye load of the M phi. These results indicate that M phi interact with IEC by adhesion and possibly through gap junctions and may thus regulate IEC function by direct cell-cell communication.
An efficient small signal frequency analysis method of nonlinear circuits with two frequency excitations (1990)

One of the excitations, 'carrier', is a large signal and an arbitrary T-periodic function of time. The other excitation, 'signal', is considered as a small perturbation to the periodic steady-state response driven by the carrier. To find a small signal frequency response for the 'signal', the method uses variational equations around the periodic steady-state response. These linearized time-varying differential equations are solved in the frequency domain using a time discretization method. The method can be used to compute the small signal frequency responses of nonideal switched capacitor filters, mixers, and other nonlinear circuits, if the circuit has a stable periodic response. The formulation of the problem, computational complexity of the method, error analysis, sensitivity analysis, implementation of the method, and some applications are covered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
(Invited) High Power Phosphor-Free InGaN/GaN/AlGaN Core-Shell Nanowire White Light Emitting Diodes on Si Substrates (2014)

We have identified that the extremely low carrier injection efficiency in nanowire light emitting diodes is mainly due to the severe carrier loss through nonradiative surface recombination. Such a bottleneck can be effectively addressed by utilizing an in situ grown AlGaN shell surrounding the InGaN/GaN dot-in-a-wire LED structures, leading to significantly enhanced carrier injection efficiency and output power. Moreover, the quality of white-light emission from such core-shell nanowire LEDs including the color temperature and color rendering index can also be massively improved by further optimizing the device structure for example the size and the In compositions of the InGaN dots in a single epitaxial growth step.
Effects of feeder design, gender, and dietary concentration of dried distillers grains with solubles on the growth performance and carcass characteristics of growing-finishing pigs (2009)

A 2 Ã— 2 Ã— 2 factorial experiment was conducted to evaluate the interactive effects of feeder design (conventional dry vs. wet-dry feeder), gender (barrow vs. gilt), and dietary concentration of dried distillers grains with solubles (DDGS; 20% vs. 60%) on finishing pig performance. A total of 1,080 pigs (PIC 337 Ã— 1050) were used in the 99-d experiment. Pigs were sorted by gender (barrows and gilts) into groups of 27, weighed (77.4 lb initial BW), allotted to pens containing 1 of the 2 feeder types, and assigned to a corn-soybean meal-DDGS-based feeding program of either 20% or 60% DDGS. A completely randomized design was used to evaluate the 8 treatment combinations, with 5 pens per treatment. This provided 20 pens per treatment for each of the three main effects (feeder type, gender, and DDGS concentration). All pigs were fed their assigned level of DDGS in 3 dietary phases (d 0 to 28, 28 to 56, and 56 to 78). On d 78, 2 pigs per pen were weighed and harvested. Jowl fat samples were collected from these pigs for fatty acid analysis and iodine value (IV). All remaining pigs were fed a common diet from d 78 to 99 that contained 20% DDGS and 4.5 g/ton of ractopamine HCl (Paylean; Elanco Animal Health, Indianapolis, IN). On d 99, all remaining pigs were harvested and carcass data were obtained from 885 pigs. Jowl fat samples were collected from 2 pigs per pen for fatty acid analysis and IV. Overall (d 0 to 99), pigs using the wet-dry feeder had greater (P < 0.001) ADG, ADFI, F/G, final BW, feed cost per pig, HCW, and backfat depth but decreased (P < 0.05) fat-free lean, jowl fat IV, premium per pig, value per cwt live, and net income per pig. Feeding 60% DDGS from d 0 to 78 resulted in decreased (P < 0.02) ADG, final BW, feed cost per pig, HCW, and backfat depth but increased (P < 0.05) F/G, fat-free lean, jowl fat IV, and net income per pig. Barrows had greater (P < 0.01) ADG, ADFI, F/G, final BW, feed cost per pig, HCW, and backfat depth but reduced fat-free lean, jowl fat IV, premium per pig, value per cwt live, and net income per pig. In conclusion, the greatest net income per pig resulted from feeding gilts 60% DDGS from d 0 to 78 and 20% DDGS with
<title>Investigation of the properties of photosensitive polyimide films</title> (1996)

Modem package designs generate a large amount of stress on the die which can be controlled using a thick film of polyimide over the passivation layer. Polyimide film thicknesses in excess of twenty microns at exposure are becoming common for very thin packages. The standard polyimide lithographic process frequently utilizes a trilayer film consisting of an adhesion layer, a polyimide film, and photoresist. A major advance in polyimide technology occurred with the introduction of photosensitive polyimide materials. These materials reduce the total number of process steps in the polyimide process. They also offer the opportunity to combine the passivation and polyimide lithography steps into one process level resulting in significant process simplification and manufacturing cost reduction. Consequently, there is a rapid increase in the use of photosensitive polyimides in the semiconductor industry. There are a number of important issues associated with photosensitive polyimide processing. Because most photosensitive polyimides are negative tone, residual film formation has a major impact on resolution and the usable process window. The high exposure doses required for thicker polyimide films exacerbates the residual film problem. Also, resolving small features such as fuse windows in DRAMs is frequently required in thick photosensitive polyimide layers. These small features result in polyimide height-to-linewidth aspect ratios that are comparable to many photoresist applications. Because of these requirements, photosensitive polyimide applications could benefit from detailed process characterization to enhance resolution and increase process latitude. Unfortunately, there is scant literature pertaining to lithographic performance and lithographic process modeling for photosensitive polyimide films. An extension of basic photoresist characterization techniques for thin films can be applied to thick photosensitive polyimide processes. The develop rate characteristics and lithographic performance for several commercial photosensitive polyimide products were studied at a thickness of 12 microns. Cross sectional SEM analysis, Bossung plots, and film retention plots are used to establish relative lithographic capabilities. These experimental results are used to study the effects of polyimide physical and chemical properties on lithographic performance.
Experimental Criteria for Living Polymerizations (1992)

Abstract Seven experimental criteria for living polymerizations are critically reviewed. The limitations of the use of linear plots of M̄ n (or X̄; n ) versus conversion and linear plots of the number of polymer chains versus conversion are illustrated by an example of alkyllithium‐initiated polymerization of styrene by incremental additions of styrene with deliberate termination (5% per incremental monomer addition). The experimental criteria of using narrow molecular weight distribution and the formation of block copolymers are illustrated with practical examples and size exclusion chromatography data. The use of the terms ‘living polymerization with reversible termination’ and ‘living polymerization with reversible chain transfer’ are proposed.
Ultraviolet Light Emitting Diodes Using Non-Polar a-Plane GaN-AlGaN Multiple Quantum Wells (2003)

We report a pn-junction ultraviolet light-emitting diode (LED) with peak emission at 363 nm using a-plane GaN-AlGaN multiple quantum wells over r-plane sapphire. The peak emission wavelength does not shift with increasing pump currents-therefore establishing the feasibility of high-efficiency non-polar light emitting devices.
Germ-Line Mutation of NKX3.1 Cosegregates with Hereditary Prostate Cancer and Alters the Homeodomain Structure and Function (2006)

NKX3.1, a gene mapped to 8p21, is a member of the NK class of homeodomain proteins and is expressed primarily in the prostate. NKX3.1 exerts a growth-suppressive and differentiating effect on prostate epithelial cells. Because of its known functions and its location within a chromosomal region where evidence for prostate cancer linkage and somatic loss of heterozygosity is found, we hypothesize that sequence variants in the NKX3.1 gene increase prostate cancer risk. To address this, we first resequenced the NKX3.1 gene in 159 probands of hereditary prostate cancer families recruited at Johns Hopkins Hospital; each family has at least three first-degree relatives affected with prostate cancer. Twenty-one germ-line variants were identified in this analysis, including one previously described common nonsynonymous change (R52C), two novel rare nonsynonymous changes (A17T and T164A), and a novel common 18-bp deletion in the promoter. Overall, the germ-line variants were significantly linked to prostate cancer, with a peak heterogeneity logarithm of odds of 2.04 (P = 0.002) at the NKX3.1 gene. The rare nonsynonymous change, T164A, located in the homeobox domain of the gene, segregated with prostate cancer in a family with three affected brothers and one unaffected brother. Importantly, nuclear magnetic resonance solution structure analysis and circular dichroism studies showed this specific mutation to affect the stability of the homeodomain of the NKX3.1 protein and decreased binding to its cognate DNA recognition sequence. These results suggest that germ-line sequence variants in NKX3.1 may play a role in susceptibility to hereditary prostate cancer and underscore a role for NKX3.1 as a prostate cancer gatekeeper.
Efficient Impostor Manipulation for Real‐Time Visualization of Urban Scenery (1997)

Urban environments present unique challenges to interactive visualization systems, because of the huge complexity of the geometrical data and the widely varying visibility conditions. This paper introduces a new framework for real‐time visualisation of such urban scenes. The central concept is that of a dynamic segmentation of the dataset, into a local three‐dimensional model and a set of impostors used to represent distant scenery. A segmentation model is presented, based on inherent urban structure. A new impostor structure is introduced, derived from the level‐of‐detail approach. Impostors combine three‐dimensional geometry to correctly model large depth discontinuities and parallax, and textures to rapidly display visual detail. We present the algorithms necessary for the creation of accurate and efficient three‐dimensional impostors. The implementation of our algorithms allows interactive navigation in complex urban databases, as required by many applications.
Transition metal catalyzed oxidation of Alcell lignin, soda lignin, and lignin model compounds in ionic liquids (2010)

Lignin is a component of lignocellulosic biomass from which important aromatic compounds can potentially be obtained. In the present work, Alcell and soda lignin were dissolved in the ionic liquid 1-ethyl-3-methylimidazolium diethylphosphate (EMIM DEP) and subsequently oxidized using several transition metal catalysts and molecular oxygen under mild conditions. CoCl2·6H2O in EMIM DEP proved particularly effective for the oxidation. The catalyst rapidly oxidized benzyl and other alcohol functionalities in lignin, but left phenolic functionality and 5–5′, β-O-4 and phenylcoumaran linkages intact, as determined by analysis of various lignin model compounds and ATR-IR spectroscopy. The catalyst system oxidized the alcohol functionality contained in cinnamyl alcohol to form cinnamaldehyde or cinnamic acid or disrupted the double bond to form benzoic acid or an epoxide. The benzyl functionality in veratryl alcohol, a simple non-phenolic lignin model compound, was selectively oxidized to form veratraldehyde at a maximum turnover frequency of 1440 h−1, compared to 10–15 h−1 reported for earlier systems. Phenolic functional groups contained in guaiacol, syringol, and vanillyl alcohol remained intact, although the benzyl alcohol group in the latter was oxidized to form vanillin. Incorporation of strongly bound tetradentate ligands to the catalyst yielded reduced activity relative to those derived from simple metal salts in EMIM DEP. The influence of reaction conditions, such as temperature, oxygen pressure and NaOH loading, were also investigated. The system represents a potential method in a biorefinery scheme to increase the oxygen functionality in lignin prior to depolymerization or additional functionalization of already depolymerized lignin.