gebhart/patrepeval huggingface dataset:
Sensor Mania! The Internet of Things, Wearable Computing, Objective Metrics, and the Quantified Self 2.0 (2012)

The number of devices on the Internet exceeded the number of people on the Internet in 2008, and is estimated to reach 50 billion in 2020. A wide-ranging Internet of Things (IOT) ecosystem is emerging to support the process of connecting real-world objects like buildings, roads, household appliances, and human bodies to the Internet via sensors and microprocessor chips that record and transmit data such as sound waves, temperature, movement, and other variables. The explosion in Internet-connected sensors means that new classes of technical capability and application are being created. More granular 24/7 quantified monitoring is leading to a deeper understanding of the internal and external worlds encountered by humans. New data literacy behaviors such as correlation assessment, anomaly detection, and high-frequency data processing are developing as humans adapt to the different kinds of data flows enabled by the IOT. The IOT ecosystem has four critical functional steps: data creation, information generation, meaning-making, and action-taking. This paper provides a comprehensive review of the current and rapidly emerging ecosystem of the Internet of Things (IOT).
Synthesis of acryl- and methacryl-type macromonomers and telechelics by utilizing living polymerization of 2-oxazolines (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of acryl- and methacryl-type macromonomers and telechelics by utilizing living polymerization of 2-oxazolinesShiro Kobayashi, Eiji Masuda, Shinichiro Shoda, and Yasuo ShimanoCite this: Macromolecules 1989, 22, 7, 2878–2884Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ma00197a002https://doi.org/10.1021/ma00197a002research-articleACS PublicationsRequest reuse permissionsArticle Views1427Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-term effects of partially hydrogenated herring oil on the rat myocardium. (1982)

Male Sprague-Dawley rats were fed semisynthetic diets containing 25% (w/w) experimental lipid. A partially hydrogenated herring oil (PHHO), containing 25% C22:1 as an isomeric mixture dominated by cetoleic (cis-docos-11-enoic), but partially altered to the trans form and containing other positional isomers, was compared with lard:corn oil 3:1(LCO) (w/w). The feeding period extended up to 111 weeks. Ten animals from both groups each were sacrificed at 2, 8, 16, 24, and 32 weeks. The remaining animals from each group were kept on the diets either until spontaneous death occurred or until Week 111. The LCO rats had higher serum cholesterol levels. The PHHO rats had transient myocardial lipidosis and very severe, progressive myocardial inflammation and scarring.
Proteus syndrome: diagnosis in adulthood (1998)

We describe a 24-year-old woman with many of the classical features of the Proteus syndrome. In childhood she had undergone bilateral forefoot amputations because of massive bilateral cerebriform hypertrophy of the feet. Other features include abnormally large fingers on one hand, a lymphangioma circumscriptum, an epidermal naevus, prominent venous varicosities and scattered lipomas. The disorder occurs sporadically and is thought to be secondary to a postzygotic mutation that survives by mosaicism.
Eye and Brain: The Psychology of Seeing (1967)

Pretext 1 Visions of vision 1 2 Light 14 3 Eye 24 4 Brain 67 5 Seeing brightness 84 6 Seeing movement 98 7 Seeing colours 121 8 Learning how to see 136 9 Realities of art 170 10 Illusions 194 11 Speculations 244 Bibliography and notes 256 Index 269
Radionuclides linked to a CD74 antibody as therapeutic agents for B-cell lymphoma: comparison of Auger electron emitters with beta-particle emitters. (2000)

When delivered by Ab LL1, both Auger electron and beta-particle emitters can produce specific and effective toxicity. The choice of the optimal radionuclide for therapy may depend on the ease and efficiency of labeling, the specific activity obtained, the nature of the tumor being targeted, and other factors, but the high specificity indices of the Auger electron emitters may be an advantage.
Neoplastic transformation in cell cultures: in-vitro/in-vivo correlations. (1985)

The behaviour of the C3H 10T1/2 C18 (10T1/2) cell line is reviewed in the context of its ability to reflect accurately events known to occur during carcinogenesis in vivo. It is concluded that, despite their embryonic fibroblastic origin and their infinite life-span in culture, 10T1/2 cells are capable of a wide range of responses to carcinogens and modulators of carcinogenesis that correspond closely to those observed in vivo, for the most part in epithelial tissues. For this and other reasons the 10T1/2 cell line has been widely employed in cancer research.
Developing evidence based policy in ageing well (2013)

Developing Evidence-based Policy in Ageing WellPopulation ageing has driven an increasing government interest in policies and practices to support ageing well. However, the complexity of interacting factors influencing the quality of the ageing experience means that ensuring that such policy and practice initiatives are evidence based presents a major challenge for policy makers. The purpose of this project was to construct a policy design framework to assist policy makers in this task. The project involved the critical analysis of a broad range of ageing well policy documents. While these initiatives showed a robust use of evidence in understanding the challenges of an ageing population and identifying the factors associated with ageing well, the strategic responses to these issues were notable for their lack of an evidence base. The complex and context specific nature of factors influencing the ageing experience both complicate the process of identifying appropriate evidence and limit the utility and transferability of any identified research evidence and/or models. Also, such evidence remains relatively scarce because, while it can only really be generated within the real world practice context, bureaucratic and political processes and timelines are relatively un- supportive of reflective and evaluative practice. We argue for an acknowledgement that complex policy initiatives, to a large extent, need to learn by doing. We propose utilising a program logic framework to identify relevant mid-level theoretical evidence in the initial design stage but to build on that evidence and refine both policy and practice through rigorous and continuous quality improvement evaluation.
Light Induces Programmed Cell Death by Activating Multiple Independent Proteases in a Cone Photoreceptor Cell Line (2006)

The activation of multiple proteases by light-induced stress is a relevant finding for studies conducted to investigate the use of pharmaceutical agents to retard or cure the loss of cone photoreceptors observed in age-related macular degeneration and other degenerative retinal diseases.
Fluorescent-Labeled Selective Adenosine A2BReceptor Antagonist Enables Competition Binding Assay by Flow Cytometry (2018)

Fluorescent ligands represent powerful tools for biological studies and are considered attractive alternatives to radioligands. In this study, we developed fluorescent antagonists for A<sub>2B</sub> adenosine receptors (A<sub>2B</sub>ARs), which are targeted by antiasthmatic xanthines and were proposed as novel targets in immuno-oncology. Our approach was to merge a small borondipyrromethene (BODIPY) derivative with the pharmacophore of 8-substituted xanthine derivatives. On the basis of the design, synthesis, and evaluation of model compounds, several fluorescent ligands were synthesized. Compound 29 (PSB-12105), which displayed high affinity for human, rat, and mouse A<sub>2B</sub>ARs ( K<sub>i</sub> = 0.2-2 nM) and high selectivity for this AR subtype, was selected for further studies. A homology model of the human A<sub>2B</sub>AR was generated, and docking studies were performed. Moreover, 29 allowed us to establish a homogeneous receptor-ligand binding assay using flow cytometry. These compounds constitute the first potent, selective fluorescent A<sub>2B</sub>AR ligands and are anticipated to be useful for a variety of applications.
Rosuvastatin: A New HMG-CoA Reductase Inhibitor for the Treatment of Hypercholesterolemia (2003)

Because of their excellent tolerability and their positive impact on lipid parameters, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have become the drugs of first choice for many patients with dyslipidemia. Rosuvastatin is an investigational statin in the U.S. with a number of favorable characteristics, which include low lipophilicity, high hepatocyte selectivity, minimal metabolism, and a low propensity for cytochrome P450 drug interactions. Rosuvastatin has been studied at doses ranging from 1 to 80 mg. In comparative clinical trials, rosuvastatin given at 5 to 10 mg/day reduced low-density lipoprotein cholesterol to a significantly greater extent than atorvastatin 10 mg/day, pravastatin 20 mg/day, and simvastatin 20 mg/day. In addition, rosuvastatin exhibited beneficial effects on other lipid parameters such as high-density lipoprotein cholesterol and triglycerides. Rosuvastatin's safety profile was demonstrated to be similar to those of other statins. Given its favorable pharmacokinetic and pharmacodynamic characteristics, rosuvastatin is likely to become a valuable addition to the statin drug class. The author reviews the pharmacologic and pharmacokinetic properties of this new statin.
Genetics of melanoma. (1990)

The goal of genetic analysis of malignant melanoma is to identify genes involved in the transformation of melanocytes and melanoma tumour progression. Three basic approaches have been used to analyze tumour progression in melanoma, and these include: (1) performing genetic linkage analysis on familial melanoma to identify the chromosomal location of genes which predispose individuals to melanoma; (2) examining tumours cytogenetically to identify frequently rearranged regions of the genome which presumably mark the location of genes involved in the evolution of melanoma; and (3) screening melanomas, using molecular techniques, to identify mutated oncogenes or tumour suppressor genes that play crucial roles in melanoma development. These studies provide strong evidence that genes on chromosomes 1, 6, 7 and 9 are involved in the aetiology of human melanoma.
Cloning of a DNA fragment from the left-hand terminus of the adenovirus type 2 genome and its use in site-directed mutagenesis (1981)

The HpaI E fragment (0-4.5 map units) of adenovirus type 2 (Ad2) DNA was cloned in the plasmid vector pBR322. Excision of the viral insert with PstI and XbaI generated a fragment which comigrated with Ad2 XbaI-E (0-3.8 map units), and this fragment was ligated to the 3.8-100 fragment generated by XbaI cleavage of the DNA of the Ad5 mutant, dl309 (N. Jones and T. Shenk, Cell 17:683-689, 1979). Transfection with the ligation products resulted in the production of progeny virus which was able to replicate on both HeLa and line 293 cells, demonstrating the biological activity of the sequences rescued from the plasmid. Small deletions were introduced around the SmaI site (map position 2.8) within the cloned viral insert, and the altered DNA sequences were reintroduced into progeny virus as described above. The mutant viruses grew well on line 293 cells but plaqued with greatly reduced efficiency on HeLa cells, exhibiting a host range phenotype similar to previously described mutants with lesions located within this region of the genome. When plasmid-derived left-end fragments containing pBR322 DNA sequences to the left of map position 0 were ligated to the 3.8-100 fragment of dl309 DNA, the infectivity of the ligation products was not reduced. However, all progeny viruses examined yielded normal-size restriction enzyme fragments from their left-hand ends, indicating that the bulk of the pBR322 DNA sequences are removed either prior to or as a consequence of the replication of the transfecting DNA molecules.
The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules (2017)

Mitochondrial gene expression is a fundamental process that is largely dependent on nuclear-encoded proteins. Several steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modification, appear to be spatially organized into distinct foci, which we have previously termed mitochondrial RNA granules (MRGs). Although an increasing number of proteins have been localized to MRGs, a comprehensive analysis of the proteome of these structures is still lacking. Here, we have applied a microscopy-based approach that has allowed us to identify novel components of the MRG proteome. Among these, we have focused our attention on RPUSD4, an uncharacterized mitochondrial putative pseudouridine synthase. We show that RPUSD4 depletion leads to a severe reduction of the steady-state level of the 16S mitochondrial (mt) rRNA with defects in the biogenesis of the mitoribosome large subunit and consequently in mitochondrial translation. We report that RPUSD4 binds 16S mt-rRNA, mt-tRNA<sup>Met</sup>, and mt-tRNA<sup>Phe</sup>, and we demonstrate that it is responsible for pseudouridylation of the latter. These data provide new insights into the relevance of RNA pseudouridylation in mitochondrial gene expression.
Biological Augmentation of Rotator Cuff Tendon Repair (2008)

A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.
Risk factors for relapse after complete remission with high-dose therapy for multiple myeloma (2006)

Complete remission (CR) is an important surrogate for long-term survival for patients with multiple myeloma. However, most patients achieving CR eventually relapse and die from their disease. To better define the predictors of relapse, we conducted a retrospective review of outcomes for patients who achieved CR after autografting at our institution. From January 1990 to December 2002, among >400 patients transplanted, 81 (54 males and 27 females) achieved CR. With a median follow up of 58 months for all surviving patients, the 5-year progression-free survival (PFS) was 33% [95% confidence interval (CI) = 23 - 44] and 5-year overall survival (OS) was 67% (95% CI = 54 - 77). Median PFS was 37 months and median OS has not yet been reached. On multivariate analysis, high tumor mass at diagnosis emerged as a predictor of poor outcome. We conclude that high tumor mass at diagnosis predicts a significantly shorter remission duration for myeloma patients undergoing autografting.
Assessing cytotoxicity of (iron oxide‐based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes (2009)

Iron oxide nanoparticles are the most widely used T(2)/T(2)* contrast agents and for biomedical research purposes, one of the main applications is the in vitro labeling of stem or therapeutic cells, allowing them to be subsequently tracked in vivo upon transplantation. To allow this, the nanoparticles used should not show any sign of cytotoxicity and not affect cellular physiology as this could impede normal cell functionality in vivo or lead to undesired side-effects. Assessing the biocompatibility of the nanoparticles has proven to be quite a difficult task. In the present work, a small overview of commonly used assays is presented in order to assess several aspects, such as cell viability, induction of reactive oxygen species, nanoparticle uptake, cellular morphology, cellular proliferation, actin cytoskeleton architecture and differentiation of stem cells. The main focus is on comparing the advantages and disadvantages of the different assays, highlighting several common problems and presenting possible solutions to these problems as well as pointing out the high importance of the relationship between intracellular nanoparticle concentration and cytotoxicity.
Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma (2011)

We recently reported deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Functional analyses confirmed that PTPN2 acts as classical tumor suppressor repressing the proliferation of T cells, in part through inhibition of JAK/STAT signaling. We investigated the expression of PTPN2 in leukemia as well as lymphoma cell lines. We identified bi-allelic inactivation of PTPN2 in the Hodgkin's lymphoma cell line SUP-HD1 which was associated with activation of the JAK/STAT pathway. Subsequent sequence analysis of Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma identified bi-allelic inactivation of PTPN2 in 2 out of 39 cases of peripheral T-cell lymphoma not otherwise specified, but not in Hodgkin's lymphoma. These results, together with our own data on T-cell acute lymphoblastic leukemia, demonstrate that PTPN2 is a tumor suppressor gene in T-cell malignancies.
Hemolysis, Renal Failure and Death, Presumed Secondary to Bite of Brown Recluse Spider (1966)

Although the clinical course in this patient's illness was not proven to follow the bite of the brown spider, its characteristics seem identical with the proven cases reported in children. It thus would represent the first fatal case in an adult.
Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon) (1985)

No AccessJournal of Urology1 Feb 1985Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon) A.A. Malizia, H.M. Reiman, R.P. Myers, J.R. Sande, S.S. Barham, R.C. Benson, M.K. Dewanjee, and W.J. Utz A.A. MaliziaA.A. Malizia More articles by this author , H.M. ReimanH.M. Reiman More articles by this author , R.P. MyersR.P. Myers More articles by this author , J.R. SandeJ.R. Sande More articles by this author , S.S. BarhamS.S. Barham More articles by this author , R.C. BensonR.C. Benson More articles by this author , M.K. DewanjeeM.K. Dewanjee More articles by this author , and W.J. UtzW.J. Utz More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)48966-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon)." The Journal of Urology, 133(2), pp. 353–354 © 1985 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 133Issue 2February 1985Page: 353-354 Advertisement Copyright & Permissions© 1985 by The American Urological Association Education and Research, Inc.MetricsAuthor Information A.A. Malizia More articles by this author H.M. Reiman More articles by this author R.P. Myers More articles by this author J.R. Sande More articles by this author S.S. Barham More articles by this author R.C. Benson More articles by this author M.K. Dewanjee More articles by this author W.J. Utz More articles by this author Expand All Advertisement PDF downloadLoading ...
Predicate Migration: Optimizing Queries with (1992)

The traditional focus of relational query optimization schemes has been on the choice of join methods and join orders. Restrictions have typically been handled in query optimizers by predicate pushdown rules, which apply restrictions in some random order before as many joins as possible. These rules work under the assumption that restrictions is essentially a zerO- time operation. However, today''s extensible and object-oriented database systems allow users to define time-consuming functions, which may be used in a query''s restriction and join predicates. furthermore, SQL has long supported subquery predicates, which may be arbitrarily time-consuming to check. Thus restrictions should not be considered zero-time operations, and the model of query optimization must be enhanced. In this paper we develop a theory for moving expensive predicates in a query plan so that the total cost of the plan--including the costs of both joins and restrictions--is minimal. We present an algorithm to implement the theory, as well as results of our implementation in POSTGRES. Our experience with the newly enhanced POSTGRES are orders of magnitude faster than plans generated by a traditional query optimizer. The additional complexity of considering expensive predicates during optimization is found to be manageably small.
天空与云朵 大海和浪花——蓝白剑条衫 (2004)

蓝与白,能让人想到什么如果是阿根廷,就是天空与云朵的交织,当激荡的风在潘帕斯的旷野上奔跑,仿佛风吹着云,云上托起纯粹的天空,在绿菌场上美丽地绽放;如果是波尔图,就是大海和浪花的涌动,那蔚蓝的水在大西洋的广阔里铺展,竟如水升起浪,浪花里飞出澎湃的海洋,在绿茵场上肆意地奔腾。在足球史上,最美丽的蓝白剑条衫当属阿根廷队(题图)的战袍,白得纯粹,蓝得动人,自从1978年世界杯它紧紧地牵住世人的视线,它就成了万千球迷的最爱。从1978年到1990年的12年间,四届世界杯,阿根廷队三度进人决赛,两次捧起大力神杯;肯佩斯、马拉多纳、帕萨雷拉、卡尼吉亚、戈耶切亚……一代阿根廷英雄令人景仰。而在辽阔的潘帕斯草原之上,绿茵场的英雄层出不穷前有斯塔维莱、费雷拉、斯蒂法诺、比安奇……后有巴蒂斯图塔、雷东多、克雷斯波、里克尔梅……