gebhart/patrepeval huggingface dataset:
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome (1999)

Obstructive sleep apnea syndrome (OSAS) may be one of the most important risk factors of cardiovascular disorders, although the exact mechanism remains to be elucidated. In the present study, we hypothesized that OSAS-induced hypoxic stress might be involved in the etiology of cardiovascular disorders by activating adhesion molecules, including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and L-selectin. To examine this hypothesis, we measured circulating ICAM-1, VCAM-1, and L-selectin levels before and after sleep in OSAS patients and age-matched controls. The circulating ICAM-1, VCAM-1, and L-selectin levels increased in the OSAS patients before sleep compared with the normal subjects (ICAM-1: 392.9 +/- 48.5 vs. 201.2 +/- 55.0 ng/ml, P < 0.05; VCAM-1: 811.0 +/- 87.8 vs. 574.2 +/- 42.7 ng/ml, P < 0.05; L-selectin: 1,386.6 +/- 77.9 vs. 1,038.8 +/- 78.6 ng/ml, P < 0.01, respectively). After sleep, significantly greater levels of ICAM-1 and L-selectin, but not VCAM-1, were observed in the OSAS group. These observations suggest that OSAS-induced hypoxia activates adhesion molecules, resulting in the important risk factor of cardiovascular disorders. Treatment of OSAS can be, therefore, a potential approach to prevention of cardiovascular events.
High topoisomerase IIα expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas (2000)

The role of molecular markers predicting the prognosis and the selection of patients for further adjuvant therapies is not well established in oligodendroglioma patients. A potential prognostic as well as a therapeutically predictive factor, topoisomerase IIalpha (topoIIalpha), is a molecular target for certain cytotoxic drugs. Its expression has been shown to correlate with the prognosis in a number of different cancers and with the chemosensitivity of cancer cells in vitro. The expression of topoIIalpha was evaluated immunohistochemically in 59 oligodendrogliomas and in 29 mixed gliomas with a predominating oligodendroglioma component by the use of a tissue microarray technique. In the gliomas, the percentage of topoIIalpha immunopositive cells protein expression varied from 0.0 to 49.1% (5.2 +/- 8.3%, mean+/- SD). In oligoastrocytomas, the mean topoIIalpha score was significantly higher in the oligodendroglioma than in the astrocytoma component of the tumour (5.37 +/- 5.58% vs. 1.89 +/- 2.49%, P = 0.018). A significant association was found between the high proportion of topoIIalpha positive cells and high grade of the tumour (P < 0.0001), high tumour proliferation rate (P < 0.0001), p53 overexpression (P = 0.01) and high expression of tumour suppressing retinoblastoma protein (P = 0.023). TopoIIalpha expression was not associated with the age or sex of patient, and the rate of apoptosis. TopoIIalpha expression associated highly significantly with patient prognosis; a significantly higher proportion of patients with low rather than with high topoIIalpha score was alive at the end of the 5-year follow-up (P = 0.03). Cox analysis was used to demonstrate that topoIIalpha had an independent prognostic value for survival (P = 0.034). In conclusion, high topoIIalpha expression characterizes oligodendrogliomas and oligoastrocytomas which are poorly differentiated, have high proliferation rate, and has prognostic value for overall survival of these patients. Therefore, topoIIalpha may be a useful marker for better targeted selection of poor prognosis oligodendroglioma patients for adjuvant therapy.
Quality in metadata: a schema for e‐commerce (2006)

Purpose An issue of increased interest in metadata research concerns finding ways to store, in the metadata of an information resource, data regarding the resource's quality. The purpose of this paper is to present a metadata schema that facilitates representation and storage of data related to the quality of an e‐commerce resource, the e‐commerce evaluation metadata (ECEM) schema. Design/methodology/approach A study of quality approaches that can be applied for the evaluation of e‐commerce resources is provided. The ECEM schema structure and elements are described. To demonstrate how ECEM can be used, two indicative examples are given: describing an e‐commerce quality approach, and storing quality evaluation results. A discussion about the validation and implementation of ECEM is also provided. Findings It has been demonstrated that ECEM can be effectively used to describe e‐commerce quality approaches. ECEM also facilitates the structured representation and storage of quality evaluation results. It is recommended that ECEM metadata be encoded using the eXtensible markup language (XML); thus, a corresponding XML schema has been produced. Originality/value Metadata about resources' quality has been developed ad hoc , according to the needs of each particular application domain, and cannot be applied in other contexts. E‐commerce is one application domain where no such contributions currently exist. ECEM is a step towards the reusable and interoperable storage of quality information in metadata. It is expected to facilitate a large number of potential applications, such as quality‐oriented search of e‐commerce resources and reusable storage of evaluation results.
Metal-free aerobic oxidative coupling of amines to imines (2011)

Oxidative coupling of primary amines to imines is achieved with high to moderate yields by refluxing suspensions of amines and water under one atmosphere dioxygen without any additives. Tandem acid-free aza Diels-Alder reactions for synthesis of N-alkyl-4-pyridones are also accomplished.
Efficacy, Biodistribution, and Pharmacokinetics of CD22-Targeted Pegylated Liposomal Doxorubicin in a B-cell Non–Hodgkin's Lymphoma Xenograft Mouse Model (2010)

IL-PLD has increased efficacy without increased toxicity compared with PLD. This suggests that IL-PLD may be an improved form of DXR-based therapy of NHL.
Photosynthetic unit size, carotenoids, and chlorophyll—protein composition of Prochloron sp., a prokaryotic green alga (1978)

Six samples of the prokaryotic, unicellular algae Prochloron sp., which occur in association with didemnid ascidians, were collected from various localities in the tropical Pacific Ocean, and their pigments and chlorophyll-protein complexes were identified and characterized. No phycobilin pigments were detected in any of the species. Chlorophylls a and b were present in ratios of a/b = 4.4-6.9. The major carotenoids were beta-carotene (70%) and zeaxanthin (20%). Minor carotenoids of one isolate were identified as echinenone, cryptoxanthin, isocryptoxanthin, mutachrome, and trihydroxy-beta-carotene; no epsilon-ring carotenoids were found in any sample. Except for the absence of glycosidic carotenoids, the overall pigment composition is typical of cyanobacteria. A chlorophyll a/b-protein complex was present in Prochloron; it was electrophoretically and spectrally indistinguishable from the light-harvesting chlorophyll a/b-protein of higher plants and green algae. It accounted for 26% (compared to approximately 50% in green plants) of the total chlorophyll; 17% was associated with a P700-chlorophyll a-protein. The photosynthetic unit size of 240 +/- 10 chlorophylls per P700 in Prochloron was about half that of eukaryotic green plants. A model is proposed for the in vivo organization of chlorophyll in Prochloron.
Magnetic Resonance Imaging of Nude Mice With Heterotransplanted High-Grade Squamous Cell Carcinomas (2002)

Gd-albumin is efficiently accumulated in SCC transplants. MRI with low loaded Gd-albumin may offer relevant opportunities for recognizing tumors sensitive to a therapy with cyostic drug-labeled albumins.
Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels (1987)

Abstract A new modification of silver staining is presented which utilizes two chemical properties of thiosulfate: image enhancement by pretreatment of fixed gels, and formation of soluble silver complexes which prevents unspecific background staining during image development. This procedure provides high sensitivity for proteins, RNA and DNA in the nanogram range on a colorless, transparent background. The performance of this method is documented by staining one‐and two‐dimensional patterns of plant leaf proteins. Moreover, we achieved, for the first time, the detection of the non‐structural, tobacco mosaic virus‐specific 126 kDa protein directly in the one‐dimensional protein pattern of infected protoplasts by a staining procedure.
Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity. (1986)

A cDNA clone representing the mRNA coding sequence of the fusion glycoprotein (F) gene of human respiratory syncytial virus (RSV) was constructed and inserted into the thymidine kinase gene of vaccinia virus (WR strain) under the control of a vaccinia virus promoter. The resulting recombinant vaccinia virus, vaccinia F, expressed the F1 and F2 cleavage products (48 and 20 kDa, respectively) of the F glycoprotein in cell culture. F1 and F2 were indistinguishable from their authentic RSV counterparts with respect to glycosylation, disulfide linkage, electrophoretic mobility, cell-surface expression, and antigenic specificity. Cotton rats infected intradermally with vaccinia F developed a high titer of serum F-specific antibodies, which neutralized infectivity of RSV. This neutralizing antibody response exceeded that induced by infection of the respiratory tract with RSV and was 6-fold higher than that induced by vaccinia G, a recombinant vaccinia virus that expressed the RSV G glycoprotein gene. Immunization with vaccinia F stimulated almost complete resistance to replication of RSV in the lower respiratory tract as well as significant resistance in the upper respiratory tract. The degree of resistance conferred by vaccinia F exceeded that induced by vaccinia G.
Synthesis of Saponins Using Partially Protected Glycosyl Donors (2003)

[reaction: see text] A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.
Characterization and assay of tartrate-resistant acid phosphatase activity in serum: potential use to assess bone resorption. (1987)

We improved the spectrophotometric assay of tartrate-resistant acid phosphatase (TrACP; EC 3.1.3.2) activity in serum. During development of the assay we found that human serum contains a dialyzable, mixed-type noncompetitive inhibitor(s) of TrACP activity, the effects of which on the assay were substantially lessened by diluting the serum sample with water before assay and increasing the substrate concentration. Hemolysis releases into serum a significant amount of TrACP activity from erythrocytes, which can be inactivated by incubating the serum at 37 degrees C for 1 h before assay. Our improved assay was reproducible (CV = 5%), and measured within 10% of the amount of added bovine skeletal TrACP activity. Preliminary application of the assay revealed that the amount of serum TrACP activity in patients with skeletal diseases differed from normal values and changed in the same direction as the expected change in bone turnover, suggesting that TrACP activity in serum could be useful clinically as a marker of bone metabolism, possibly of bone resorption.
Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes. (1993)

Ribonucleoparticle-independent transport of precursor proteins into mammalian microsomes is stimulated by 70-kDa heat shock proteins (Hsc70) and an additional cytosolic protein. Here we addressed the question of whether other molecular chaperones can replace Hsc70 in facilitating protein transport into the endoplasmic reticulum. Specifically, we asked if members of the same family of stress proteins, i.e. the microsomal protein immunoglobulin heavy chain binding protein or the bacterial protein DnaK, can substitute for Hsc70. Furthermore, we investigated whether molecular chaperones with a proven role in protein folding and belonging to the other two major families of stress proteins, i.e. Hsp60 or Hsp90, can substitute for Hsc70. We show that none of these stress proteins was able to substitute for Hsc70 in facilitating protein transport into mammalian microsomes. GroEL (the bacterial member of the Hsp60 family) and Hsp90, however, competed with Hsc70 for binding of the non-native precursor protein. Therefore, we conclude that there are both substrate and functional specificity in the action of molecular chaperones.
Characterization of (PEO)LiClO4‐Li1.3Al0.3Ti1.7(PO4)3 composite polymer electrolytes with different molecular weights of PEO (2006)

Abstract A group of polyethylene oxide (PEO)LiClO 4 ‐Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 composite polymer electrolyte (CPE) films was prepared by the solution‐cast method. In each film, EO/Li = 8 and the Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 content of 15 wt % were fixed, but the number averaged molecular weight of PEO ( M n ) was altered from 5 to 7 × 10 4 to 10 6 , 2.2–2.7 × 10 6 , 3–4 × 10 6 , 4–5 × 10 6 , and 5.5–6 × 10 6 , respectively. Several techniques including X‐ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and electrical impedance spectroscopy (EIS) were used to characterize the CPE films. LiClO 4 was found to have a strong tendency to complex with PEO, but Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 was rather dispersed in PEO matrix. DSC analysis revealed that the amorphous phase was dominant in the CPE films although the PEOs before‐use was considerably crystalline. SEM study showed smooth and homogeneous morphologies of the films with low molecular weight PEO and a dual phase characteristic for those with high molecular weight PEO. EIS results indicated that the CPE films are all ionic conductor and the conducting behavior obeys Vogel‐Tamman‐Fulcher (VTF) equation. The parameters in VTF equation were obtained and discussed by taking into considerations PEO molecular weights and crystallinities of the CPE films. Of all the films, the one with PEO with the smallest M n = 5–7 × 10 4 had the maximum conductivity, i.e., 1.590 × 10 −5 S cm −1 at room temperature and 1.886 × 10 −3 S cm −1 at 373 K. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 4269–4275, 2006
Compiler-assisted dynamic scheduling for effective parallelization of loop nests on multicore processors (2009)

Recent advances in polyhedral compilation technology have made it feasible to automatically transform affine sequential loop nests for tiled parallel execution on multi-core processors. However, for multi-statement input programs with statements of different dimensionalities, such as Cholesky or LU decomposition, the parallel tiled code generated by existing automatic parallelization approaches may suffer from significant load imbalance, resulting in poor scalability on multi-core systems. In this paper, we develop a completely automatic parallelization approach for transforming input affine sequential codes into efficient parallel codes that can be executed on a multi-core system in a load-balanced manner. In our approach, we employ a compile-time technique that enables dynamic extraction of inter-tile dependences at run-time, and dynamic scheduling of the parallel tiles on the processor cores for improved scalable execution. Our approach obviates the need for programmer intervention and re-writing of existing algorithms for efficient parallel execution on multi-cores. We demonstrate the usefulness of our approach through comparisons using linear algebra computations: LU and Cholesky decomposition.
MARS: Femtosecond laser mask advanced repair system in manufacturing (1999)

Presently available nanosecond laser based tools for removing Cr defects from photomasks have proven inadequate to the task due to the thermal nature of the ablation process which produces metal splatter, haze, reduced transmission, and pitting of the quartz substrate. These problems are virtually nonexistent when employing femtosecond pulses of light to ablate Cr defects in a nonthermal process. Photomasks repaired with ultrashort light pulses exhibit transmission approaching 100%, no observable glass damage, and exceptional spatial resolution. We have built a femtosecond pulsed laser mask repair system which is presently operating successfully in a manufacturing environment.
Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study (2012)

These results suggest that health outcomes of moderate/late preterm and early term babies are worse than those of full term babies. Additional research should quantify how much of the effect is due to maternal/fetal complications rather than prematurity itself. Irrespective of the reason for preterm birth, large numbers of these babies present a greater burden on public health services than very preterm babies.
A New Product Growth for Model Consumer Durables (1969)

A growth model for the timing of initial purchase of new products is developed and tested empirically against data for eleven consumer durables. The basic assumption of the model is that the timing of a consumer's initial purchase is related to the number of previous buyers. A behavioral rationale for the model is offered in terms of innovative and imitative behavior. The model yields good predictions of the sales peak and the timing of the peak when applied to historical data. A long-range forecast is developed for the sales of color television sets.
The Arabidopsis LOS5/ABA3 Locus Encodes a Molybdenum Cofactor Sulfurase and Modulates Cold Stress- and Osmotic Stress-Responsive Gene Expression (2001)

Liming Xiong, Manabu Ishitani, Hojoung Lee, Jian-Kang Zhu, The Arabidopsis LOS5/ABA3 Locus Encodes a Molybdenum Cofactor Sulfurase and Modulates Cold Stress- and Osmotic Stress-Responsive Gene Expression, The Plant Cell, Vol. 13, No. 9 (Sep., 2001), pp. 2063-2083
The Potential of Angiogenesis Soluble Markers in Chronic Hepatitis C * (2005)

Angiogenesis, the formation of new vessels, has been reported to play a significant pathogenic role in liver damage-associated hepatitis C virus infection. Most of our current knowledge derives from immunohistochemical studies of hepatic biopsy samples obtained from chronic hepatitis C (CHC) patients. We evaluated whether CHC is associated with elevated serum levels of angiogenesis markers and whether these are modulated by therapy. Vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2), and soluble Tie-2 (sTie-2) were determined in the serum of 36 CHC patients, before and after receiving antiviral combination therapy with pegylated interferon alpha-2b plus ribavirin, and in 15 healthy controls. CHC patients showed elevated baseline VEGF and Ang-2 levels. After treatment, both factors were decreased, whereas antiangiogenic sTie-2 was increased, indicating a shift toward an "anti-angiogenic" profile of serum markers in CHC patients. In conclusion, this suggests that serum VEGF, Ang-2, and sTie-2 levels could be useful as noninvasive, mechanistically based markers of response to therapy and disease progression in CHC.
Pathogenesis-related proteins are developmentally regulated in tobacco flowers. (1989)

The accumulation of pathogenesis-related proteins (PR) in tobacco leaves has been casually related to pathogen and specific physiological stresses. The known enzymatic function of some of these proteins is potentially antimicrobial. By using antibodies specific to three classes of pathogenesis-related proteins, we examined tobacco plants during their normal growth. The pathogenesis-related proteins accumulated during the normal development of the tobacco flower. The PR-1 class of proteins (biological function unknown) is located in sepal tissue. PR-P, Q polypeptides are endochitinases and are present in pedicels, sepals, anthers, and ovaries. A glycoprotein serologically related to the PR-2,N,O class is a (1,3)-beta-glucanase and is present in pistils. Differential appearance during flower development, in situ localization, and post-translational processing of floral pathogenesis-related proteins point to a hitherto unsuspected function these classes of pathogenesis-related proteins play in the normal process of flowering and reproductive physiology.
CD44 is required for two consecutive steps in HGF/c-Met signaling (2002)

The tyrosine kinase receptor c-Met and its ligand HGF/SF, ezrin, and splice variants of CD44 have independently been identified as tumor metastasis-associated proteins. We now show that these proteins cooperate. A CD44 isoform containing variant exon v6 sequences is strictly required for c-Met activation by HGF/SF in rat and human carcinoma cells, in established cell lines as well as in primary keratinocytes. CD44v6-deficient tumor cells were unable to activate c-Met unless they were transfected with a CD44v6-bearing isoform. Antibodies to two v6-encoded epitopes inhibited autophosphorylation of c-Met by interfering with the formation of a complex formed by c-Met, CD44v6, and HGF/SF. In addition, signal transduction from activated c-Met to MEK and Erk required the presence of the cytoplasmic tail of CD44 including a binding motif for ERM proteins. This suggests a role for ERM proteins and possibly their link to the cortical actin cytoskeleton in signal transfer.
Dextran; an antigen in man. (1953)

Summary 1.Native and clinical dextrans derived from strains of microorganisms synthesizing products with different ratios of 1:6 to non 1:6 linkages have been found to be antigenic in man. Three weeks after injection of 1 mg of dextran, precipitins and cutaneous sensitivities of the wheal and erythema type develop. 2.The antigenicity of dextran in man, its occurrence in commercial sugar and its elaboration by microorganisms in the gastrointestinal tract appear to provide an explanation for the occurrence of systemic allergic reactions in man on infusion of dextran and for the occurrence of small quantities of antidextran and of cutaneous sensitivity in individuals not previously injected with dextran. 3.The precipitin reaction between dextran and antidextran is of the usual type. Differences in the behavior of various antisera with native and clinical dextran have been interpreted in terms of the structural similarities and differences among the preparations.
Oxidation-induced defect generation in advanced DRAM structures (1990)

Structures containing deep-trenched storage capacitors and shallow-trench isolation were examined in patterns suitable for future generation dynamic RAMs (DRAMs). These same effects were also examined in similar structures which included only the shallow isolation trenches. Observed was a strong interaction between the deep and shallow trenches, which makes structures which incorporate both types much more susceptible to oxidation-induced defect generation than those without deep trenches. It was observed that at higher oxidation temperatures, more oxide can be grown before defects are generated. This is interpreted as a combination of more-efficient visco-elastic relaxation in the oxide and a lower differential oxidation rate between the