gebhart/patrepeval huggingface dataset:
Surface Evolution of n-Type CdTe in Acidic Medium in the Presence of Ce4+ Ions (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface Evolution of n-Type CdTe in Acidic Medium in the Presence of Ce4+ IonsF. Iranzo Marin, J. Vigneron, D. Lincot, A. Etcheberry, and C. Debiemme-ChouvyCite this: J. Phys. Chem. 1995, 99, 41, 15198–15207Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://doi.org/10.1021/j100041a040RIGHTS & PERMISSIONSArticle Views90Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts
Fluid interaction with high-resolution wall-size displays (2001)

This paper describes new interaction techniques for direct pen-based interaction on the Interactive Mural, a large (6′x3.5′) high resolution (64 dpi) display. They have been tested in a digital brainstorming tool that has been used by groups of professional product designers. Our "interactive wall" metaphor for interaction has been guided by several goals: to support both free-hand sketching and high-resolution materials, such as images, 3D models and GUI application windows; to present a visual appearance that does not clutter the content with control devices; and to support fluid interaction, which minimizes the amount of attention demanded and interruption due to the mechanics of the interface. We have adapted and extended techniques that were developed for electronic whiteboards and generalized the use of the FlowMenu to execute a wide variety of actions in a single pen stroke, While these techniques were designed for a brainstorming tool, they are very general and can be used in a wide variety of application domains using interactive surfaces.
Differences in turnover between thymic medullary dendritic cells and a subset of cortical macrophages. (1990)

To investigate the turnover of thymic accessory cells, we performed vascular thymus transplantation in RT7 congenic rats. mAb specific for one of the two allelic variants of the RT7 molecule, as well as mAb specific for either medullary interdigitating cells or a subset of cortical macrophages (M phi), were used on cryostat sections and cell suspensions prepared from grafted thymuses to monitor the turnover of these two cell types. In contrast to the complete turnover of interdigitating cells within 3 wk after transplantation, ED2-labeled cortical M phi showed a very slow turnover. Seventy-six days after transplantation, more than 30% of these M phi were found to be still of donor origin. The different turnover rates of these thymic accessory cells could reflect their function in T cell development.
Copper(II)‐Catalyzed Highly Enantioselective Addition of Enamides to Imines: The Use of Enamides as Nucleophiles in Asymmetric Catalysis (2004)

High-yielding efficient routes to optically active amino acid and 1,3-diamine derivatives have been achieved by the catalytic enantioselective addition of enamides to imines using a chiral copper catalyst (see scheme). This reaction demonstrates the utility of enamides as nucleophiles. The reaction mechanism and the structure of the chiral catalyst are also discussed.
Adaptive filtered-back-projection for computed tomography (2008)

We propose an extension of the Filtered Back-Projection (FBP) algorithm for reconstruction of attenuation images in Computed Tomography (CT). In our scheme, the standard filtering of projections with windowed ramp kernel is replaced by an adaptive, spatially-variant linear filter, based on a structured bank of 2D convolution kernels. In addition, the proposed scheme includes a post-processing step of image filtering by convolution with a 2D adaptive filter. Both filters are trained for specified reconstruction task via an optimization of corresponding objective function. The reconstruction task is defined through (i) a representative set of specific family of images; (ii) data acquisition conditions (partial set of projections, noise level); and (iii) a Region-Of-Interest (ROI) to be recovered. The resulting adaptive scheme absorbs various imperfections of reconstruction algorithm and specializes to given task, effectively improving the reconstruction quality.
NCAM stimulates the ras-MAPK pathway and CREB phosphorylation in neuronal cells (1999)

The neural cell adhesion molecule NCAM plays an important role in axonal growth, learning, and memory. A signaling pathway has been elucidated in which clustering of the NCAM140 isoform in the neural plasma membrane stimulated the activating phosphorylation of mitogen-activated protein kinases (MAPKs) and the transcription factor cyclic AMP response-element binding protein (CREB). NCAM clustering transiently induced dual phosphorylation (activation) of the MAPKs ERK1 and ERK2 (extracellular signal-regulated kinases) by a pathway regulated by the focal adhesion kinase p125fak, p59fyn, Ras, and MAPK kinase. CREB phosphorylation at serine 133 induced by NCAM was dependent in part on an intact MAPK pathway. c-Jun N-terminal kinase, which is associated with apoptosis and cellular stress, was not activated by NCAM. Inhibition of the MAPK pathway in rat cerebellar neuron cultures selectively reduced NCAM-stimulated neurite outgrowth. These results define an NCAM signal transduction mechanism with the potential for modulating the expression of genes needed for axonal growth, survival, and synaptic plasticity.
The genetics and molecular biology of unc.-86, a C. elegans cell lineage gene (1987)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1987.
T Cell Development in CD3-ζ Mutant Mice (1995)

Increasing evidence points to multiple pathways of T lymphocyte development. The well characterized thymus-dependent pathway gives rise to T cells bearing TCR alpha beta heterodimers and either CD4 or CD8 alpha beta co-receptors. T cells of this lineage populate peripheral lymphoid compartments including lymph nodes, spleen, skin, and Peyer's patches. By comparison, factors which govern extrathymic T cell development are poorly understood. A variety of experiments have shown that intestinal intraepithelial lymphocytes (IELs) develop outside of the thymic environment, e.g., in the gut of nude, SCID, and beta 2m-/- mutant mice, and after transplanting bone marrow or fetal liver cells into irradiated thymectomized adult mice. This review focuses on the role of the CD3-zeta subunit in the development of both thymically and extrathymically derived T cells as determined by gene-targeting experiments in mice. Data from these and other T cell-related mutations continue to define crucial stages in thymocyte differentiation. Most interestingly, CD3-zeta mutant mice contain a unique population of intestinal IELs that develops independently of thymic selective processes and expresses a novel TCR/CD3 complex.
Large steps in cloth simulation (1998)

The bottle-neck in most cloth simulation systems is that time steps must be small to avoid numerical instability. This paper describes a cloth simulation system that can stably take large time steps. The simulation system couples a new technique for enforcing constraints on individual cloth particles with an implicit integration method. The simulator models cloth as a triangular mesh, with internal cloth forces derived using a simple continuum formulation that supports modeling operations such as local anisotropic stretch or compression; a unified treatment of damping forces is included as well. The implicit integration method generates a large, unbanded sparse linear system at each time step which is solved using a modified conjugate gradient method that simultaneously enforces particles' constraints. The constraints are always maintained exactly, independent of the number of conjugate gradient iterations, which is typically small. The resulting simulation system is significantly faster than previous accounts of cloth simulation systems in the literature.
New approaches to hepatitis A and B vaccines (1995)

Plasma-derived vaccines and yeast-derived recombinant vaccines against hepatitis B virus (HBV) infection have gained an acceptable record of efficacy. However, non- or hyporesponsiveness to immunization does not only occur in cases of obesity, renal failure or immune suppression, but also in healthy individuals. There is therefore a rationale for developing more immunogenic vaccines against HBV, especially for those populations who are potential non- or hyporesponders. Currently used recombinant hepatitis B vaccines consist of antigen particles assembled with the product of 226 amino acids encoded in the S gene. Since proteins encoded in the pre-S gene are also incorporated in the HBV envelope, pre-S gene products should, at least in theory, be useful in improving protection with hepatitis B vaccines. Inactivated hepatitis A vaccines are more potent than currently used hepatitis B vaccines. Two injections of a standard dose of HAVRIX (SB) by the intramuscular route, or even a single injection using a higher dose (HAVRIX 1440), will achieve protective levels of antibodies. Therefore, increased potency is not essential with inactivated hepatitis A vaccines. New hepatitis A vaccines are likely to be recombinant or attenuated live types. Another aspect of the improvement of existing hepatitis A and B vaccines is unification into a combined form.
Phenylalanine 664 of dipeptidyl peptidase (DPP) 7 and Phenylalanine 671 of DPP11 mediate preference for P2‐position hydrophobic residues of a substrate (2013)

Dipeptidyl peptidases (DPPs) are crucial for the energy metabolism in Porphyromonas gingivalis, a Gram-negative proteolytic and asaccharolytic anaerobic rod causing chronic periodontitis. Three DPPs, DPPIV specific for Pro, DPP7 for hydrophobic residues and DPP11 for Asp/Glu at the P1 position, are expressed in the bacterium. Like DPP7, DPP11 belongs to the S46 protease family, and they share 38.7% sequence identity. Although DPP11 is preferential for hydrophobic residues at the P2 position, it has been reported that DPP7 has no preference at the P2 position. In the present study, we defined the detailed P2 substrate preference of DPP7 and the amino acid residue responsible for the specificity. DPP7 most efficiently hydrolyzed Met-Leu-dipeptidyl-4-methylcoumaryl-7-amide (MCA) carrying hydrophobic residues at the P1 position with k cat/Km of 10.62 ± 2.51 μM(-1) s(-1), while it unexpectedly cleaved substrates with hydrophilic (Gln, Asn) or charged (Asp, Arg) residues. Examination with 21 dipeptidyl MCA demonstrated that DPP7-peptidase activity was dependent on hydrophobicity of the P2- as well as P1-position residue, thus it correlated best with the sum of the hydrophobicity index of P1- and P2-amino acid residues. Hydrophobicity of the P1 and P2 positions ensured efficient enzyme catalysis by increasing k cat and lowering Km values, respectively. Substitution of hydrophobic residues conserved in the S46 DPP7/DPP11 family to Ala revealed that Phe664 of DPP7 and Phe671 of DPP11 primarily afforded hydrophobic P2 preference. A modeling study suggested that Phe664 and Gly666 of DPP7 and Phe671 and Arg673 of DPP11 being associated with the P2- and P1-position residues, respectively, are located adjacent to the catalytic Ser648/Ser655. The present results expand the substrate repertoire of DPP7, which ensures efficient degradation of oligopeptides in asaccharolytic bacteria.
Nucleic Acid Enzymes as a Novel Generation of Anti-gene Agents (2001)

Recent molecular and cellular studies have highlighted the important role of some gene products in the cause and/or perpetuation of human pathological conditions including cancer and autoimmune diseases. The identification of such gene products has led to the development of new candidate therapies. The discovery of catalytic nucleic acid enzymes has provided researchers with a potentially important tool to block the expression of abnormal genes, provided that their sequences are known. The cleavage specificity of these compounds is determined by their hybridizing antisense arms, which anneal with the target mRNA in a complementary fashion. Nucleic acid enzymes can be delivered to cells either endogenously as gene encoding RNA enzymes (ribozymes) or exogenously as in vitro made agents. Given the progress reported during the last years, a wide range of molecular designs and chemical modifications can be introduced into these compounds, in particular the hammerhead type ribozyme. Here, we review the design, stability and the therapeutic application of these agents with the goals of illustrating relevant gene targets and signal pathways for molecular medicine. Relevant in vivo problems of the technology, mRNA repair by group I intron ribozymes and gene regulation by endogenous RNA will also be discussed. Keywords: Ribozyme, DNA enzyme, endogenous RNA, RNA splicing, ribonuclease III, signal transduction
Surface-enhanced resonance Raman spectroscopy of Rhodamine 6G adsorbed on colloidal silver (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-enhanced resonance Raman spectroscopy of Rhodamine 6G adsorbed on colloidal silverPeter Hildebrandt and Manfred StockburgerCite this: J. Phys. Chem. 1984, 88, 24, 5935–5944Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/j150668a038https://doi.org/10.1021/j150668a038research-articleACS PublicationsRequest reuse permissionsArticle Views8122Altmetric-Citations1301LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis in Very Low Birth Weight Infants (2005)

Infloran as probiotics fed enterally with breast milk reduces the incidence and severity of NEC in VLBW infants.
Rte‐1, a retrotransposon‐like element in Caenorhabditis elegans (1996)

We have characterized a retrotransposon-like element (Rte-1) in C. elegans. It was identified while we were sequencing the pim related kinase-1 (prk-1) gene. The element is 3,298 bp long and flanked by a 200 bp direct repeat. 95 bp of the direct repeat are present in the coding region of prk-1. Rte-1 contains an open reading frame, in the opposite orientation of prk-1, potentially encoding 625 amino acids, with similarity to reverse transcriptases. The element is most similar to members of the non-LTR group of retrotransposable elements. There is weak homology of the predicted amino acid sequence of Rte-1 to several reverse transcriptase-like genes identified by the C. elegans genome sequencing consortium, suggesting that there may be a large family of these elements. Southern blots indicate that there are approximately 10-15 additional Rte-1 elements in the C. elegans Bristol N2 genome and a similar number is found in the genomes of two other geographically distinct strains. The insertion pattern of Rte-1 is polymorphic between these strains.
Simulation and Investigation of Factors Affecting High Aspect Ratio UV Embossing (2005)

UV embossing is a replication method whereby an UV-curable polymer is pressed against a patterned mold and cured with UV irradiation, resulting in a patterned polymeric substrate. High aspect ratio UV embossing will find diverse applications in tissue engineering, micro-optics, display technologies, and sensors. Demolding of an UV-embossed polymer pattern with aspect ratio of 5 from the mold has previously been demonstrated experimentally. In this paper, parameters that affect the demolding process have been identified and investigated. They include cross-linking shrinkage during curing by UV irradiation, modulus of cured polymer, interfacial fracture strength and toughness, and loading method during demolding. Shrinkage is an important parameter, and an optimum level of shrinkage to avoid breakage of the embossing during demolding was found to exist. This optimum level is that at which the maximum stress (sigma(1)max) experienced by the polymer during demolding is minimized. The micromechanics of demolding was found to be different for shrinkage values lower or larger than the optimum value.
Transparent-cathode for top-emission organic light-emitting diodes (2003)

A transparent-charge-injection layer consisting of LiF/Al/Al-doped SiO has been developed as (i) a cathode for top-emitting organic light-emitting diodes and as (ii) a buffer layer against damages induced by energetic ions generated during deposition of other functional thin films by sputtering, or plasma-enhanced chemical vapor deposition. A luminance of 1900 cd/m2 and a current efficiency of 4 cd/A have been achieved in a simple testing device structure of indium tin oxide (ITO) N,N′-diphenyl-N,N′-bis(3-methylphenyl)-1,1′-biphenyl-4,4′-diamine (60 nm)/Alq3 (40 nm)/LiF (0.5 nm)/Al (3 nm)/Al-doped SiO (30 nm). A minimum thickness of 30 nm of Al-doped SiO is also found to protect organic layers from ITO sputtering damage.
Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines (2000)

The effects of supernatant from the bacterial strain Serratia marcescens 2170 (CS-2170) on the viability of different haematopoietic cancer cell lines (Jurkat, NSO, HL-60 and Ramos) and nonmalignant cells (NIH-3T3 and MDCK) was studied. We examined whether this cytotoxic effect was due to apoptosis, and we purified the molecule responsible for this effect and determined its chemical structure. Using an MTT assay we showed a rapid (4 h) decrease in the number of viable cells. This cytotoxic effect was due to apoptosis, according to the fragmentation pattern of DNA, Hoechst 33342 staining and FACS analysis of the phosphatidylserine externalization. This apoptosis was blocked by using the caspase inhibitor Z-VAD.fmk, indicating the involvement of caspases. Prodigiosin is a red pigment produced by various bacteria including S. marcescens. Using mutants of S. marcescens (OF, WF and 933) that do not synthesize prodigiosin, we further showed that prodigiosin is involved in this apoptosis. This evidence was corroborated by spectroscopic analysis of prodigiosin isolated from S. marcescens. These results indicate that prodigiosin, an immunosuppressor, induces apoptosis in haematopoietic cancer cells with no marked toxicity in nonmalignant cells, raising the possibility of its therapeutic use as an antineoplastic drug.
Secondary Impairment of Pancreatic Function as a Cause of Severe Malabsorption in Intestinal Giardiasis: A Case Report (1997)

We report the case of a 54-year-old male patient hospitalized for diarrhea and weight loss (8 kg over the previous three months). At admission, we observed pale oral and conjunctival mucosa and peripheral edema of the lower limbs. Stool frequency was 8-10 per day. Laboratory data were as follows: hemoglobin, 11 g/dL; total proteins, 4.3 g/dL; albumin, 2 g/dL; pseudocholinesterase, 1248 U/L; triglycerides, 54 mg/dL; serum cholesterol, 102 mg/dL; calcium, 7.9 mg/dL. Fecal fat was 8.2 g/24 hr. Fecal chymotrypsin (FCT) was 2.3 U/g. A duodenal probe was performed after administration of intravenous secretin and cerulein stimulation, and a contemporaneous mucosal biopsy was taken at the ligament of Treitz. Microscopic examination showed numerous Giardia lamblia in the fluid collected. Pancreatic enzyme activity in the duodenal fluid showed a severe reduction in lipase: 120 U/ml/min (normal value = 600 U/ml/min). Small bowel bacterial overgrowth was excluded by microbiologic examination of intestinal fluid. The patient was treated with metronidazole, leading to a complete remission of symptoms. Immediately after stopping treatment, the FCT was 15.2 U/g. Four months after hospitalization, the patient's weight had increased by 11 kg and he was asymptomatic; total proteins were 6.7 g/dL; albumin, 3.8 g/dL; triglycerides, 104 mg/dL; cholesterol, 152 mg/dL; pseudocholinesterase, 3,567 mg/dL; calcium, 10 mg/dL; steatorrhea was 3.6 g/24 hr and fecal chymotrypsin was 88 U/g. This case describes a severe, reversible impairment in pancreatic function leading to clinical malabsorption in the presence of Giardia infection.
Few-shot Adaptive Faster R-CNN (2019)

To mitigate the detection performance drop caused by domain shift, we aim to develop a novel few-shot adaptation approach that requires only a few target domain images with limited bounding box annotations. To this end, we first observe several significant challenges. First, the target domain data is highly insufficient, making most existing domain adaptation methods ineffective. Second, object detection involves simultaneous localization and classification, further complicating the model adaptation process. Third, the model suffers from over-adaptation (similar to overfitting when training with a few data example) and instability risk that may lead to degraded detection performance in the target domain. To address these challenges, we first introduce a pairing mechanism over source and target features to alleviate the issue of insufficient target domain samples. We then propose a bi-level module to adapt the source trained detector to the target domain: 1) the split pooling based image level adaptation module uniformly extracts and aligns paired local patch features over locations, with different scale and aspect ratio; 2) the instance level adaptation module semantically aligns paired object features while avoids inter-class confusion. Meanwhile, a source model feature regularization (SMFR) is applied to stabilize the adaptation process of the two modules. Combining these contributions gives a novel few-shot adaptive Faster-RCNN framework, termed FAFRCNN, which effectively adapts to target domain with a few labeled samples. Experiments with multiple datasets show that our model achieves new state-of-the-art performance under both the interested few-shot domain adaptation(FDA) and unsupervised domain adaptation(UDA) setting.
Pharmacokinetics of different routes of administration of misoprostol (2002)

The new sublingual route of administration of misoprostol demonstrated a great potential to be developed into a method of medical abortion.