gebhart/patrepeval huggingface dataset:
City-Scale Map Creation and Updating using GPS Collections (2016)

Applications such as autonomous driving or real-time route recommendations require up-to-date and accurate digital maps. However, manually creating and updating such maps is too costly to meet the rising demands. As large collections of GPS trajectories become widely available, constructing and updating maps using such trajectory collections can greatly reduce the cost of such maps. Unfortunately, due to GPS noise and varying trajectory sampling rates, inferring maps from GPS trajectories can be very challenging. In this paper, we present a framework to create up-to-date maps with rich knowledge from GPS trajectory collections. Starting from an unstructured GPS point cloud, we discover road segments using novel graph-based clustering techniques with prior knowledge on road design. Based on road segments, we develop a scale- and orientation-invariant traj-SIFT feature to localize and recognize junctions using a supervised learning framework. Maps with rich knowledge are created based on discovered road segments and junctions. Compared to state-of-the-art methods, our approach can efficiently construct high-quality maps at city scales from large collections of GPS trajectories.
A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity (1994)

The cytokines interleukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor bind with high affinity to a receptor complex that contains a ligand-specific alpha-chain and a common beta-chain, h beta c. We report here the isolation of a mutant form of h beta c, from growth factor-independent cells, that arose spontaneously after infection of a murine factor-dependent hematopoietic cell line (FDC-P1) with a retroviral h beta c expression construct. Analysis of this h beta c mutation shows that a small (37 amino acid) duplication of extracellular sequence that includes two conserved sequence motifs is sufficient to confer ligand-independent growth on these cells and lead to tumourigenicity. Because this is a conserved region in the cytokine receptor superfamily, our results suggest that the large family of cytokine receptors has the capacity to become oncogenically active.
Evidence‐based treatment strategies for treatment‐resistant bipolar depression: a systematic review (2012)

The available level I evidence for treatment strategies in resistant bipolar depression is extremely scarce, and although the response rates reported are reassuring, most of the strategies remain experimental. There is an urgent need for further study in homogeneous patient samples using a clear concept of treatment resistance.
Differential effects of flanking residues on presentation of epitopes from chimeric peptides (1994)

Chimeric peptides in which the optimal H-2d mouse hepatitis virus nucleocapsid (pN) and human immunodeficiency virus type 1 (p18) epitopes, separated by 38, 7, or 2 amino acids, were expressed from a single open reading frame by using recombinant vaccinia viruses to analyze antigen processing of proximal class I-restricted epitopes. Recognition of the carboxy-terminal Dd-restricted p18 epitope was independent of the amino-terminal flanking residues. By contrast, proximity of the carboxy-terminal epitope decreased recognition of the amino-terminal Ld-restricted pN epitope. Immunization resulted in the induction of both p18- and pN-specific antiviral cytotoxic T lymphocytes, irrespective of the number of amino acids separating the epitopes.
The role of self-administration in morphine withdrawal in rats (1997)

Rats assigned to a self-administration-of-morphine group (SA-M) could press a lever in an operant chamber to deliver an intravenous infusion of morphine to themselves and to a yoked morphine (Y-M) rat, and an infusion of Ringer’s solution to another yoked rat. Although rats assigned to SA-M and Y-M groups received the same drug doses at the same time, withdrawal symptoms were more pronounced in SA-M rats. Possible mechanisms for the differences in drug withdrawal between animals that self-administer morphine and animals that passively receive the drug are discussed.
Cloning of a Rab3 isotype predominantly expressed in adipocytes. (1992)

We have isolated the cDNA for Rab3D, an additional member of the small molecular weight GTP-binding protein family. Rab3D message is abundant in mouse adipocytes. It is increased during differentiation of 3T3-L1 cells into adipocytes, temporally coincident with the appearance of the insulin-sensitive glucose transporter GLUT4. Rab3D is a close homolog of Rab3A, which is found on the cytoplasmic surface of neurosecretory vesicles and which may be involved in their regulated secretion. Since our previous work showed that in permeabilized adipocytes nonhydrolizable GTP analogs mimic insulin in triggering exocytosis of GLUT4-containing vesicles, Rab3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes.
Atrial fibrillation and heart failure (2015)

The predominant questions that require further attention with respect to atrial fibrillation and heart failure are whether catheter ablation and rhythm control offers benefit in a high-risk heart failure population with respect to mortality or heart failure reduction, and whether cardiac resynchronization therapy implantation truly benefits the subgroup of candidate patients with permanent atrial fibrillation. Large randomized multicentre studies are currently ongoing to address these important questions.
Pyramidal implementation of the Lucas Kanade feature tracker description of the algorithm (1999)

1 Problem Statement Let I and J be two 2D grayscaled images. The two quantities I(x) = I(x, y) and J(x) = J(x, y) are then the grayscale value of the two images are the location x = [x y] , where x and y are the two pixel coordinates of a generic image point x. The image I will sometimes be referenced as the first image, and the image J as the second image. For practical issues, the images I and J are discret function (or arrays), and the upper left corner pixel coordinate vector is [0 0] . Let nx and ny be the width and height of the two images. Then the lower right pixel coordinate vector is [nx − 1 ny − 1] . Consider an image point u = [ux uy] on the first image I. The goal of feature tracking is to find the location v = u + d = [ux+dx uy +dy] on the second image J such as I(u) and J(v) are “similar”. The vector d = [dx dy] is the image velocity at x, also known as the optical flow at x. Because of the aperture problem, it is essential to define the notion of similarity in a 2D neighborhood sense. Let ωx and ωy two integers. We define the image velocity d as being the vector that minimizes the residual function defined as follows:
Two-Component Transcriptional Regulation of N -Acyl-Homoserine Lactone Production in Pseudomonas aureofaciens (1999)

Production of phenazine antibiotics by the biological control bacterium Pseudomonas aureofaciens 30-84 is regulated in part by the PhzI/PhzR N-acyl-homoserine lactone (AHL) response system (L. S. Pierson III, V. D. Keppenne, and D. W. Wood, J. Bacteriol. 176:3966-3974, 1994; D. W. Wood and L. S. Pierson III, Gene 168:49-53, 1996). Two mutants, 30-84W and 30-84.A2, were isolated and were found to be deficient in the production of phenazine, protease, hydrogen cyanide (HCN), and the AHL signal N-hexanoyl-homoserine lactone. These mutants were not complemented by phzI, phzR, or the phenazine biosynthetic genes (phzFABCD) (L. S. Pierson III, T. Gaffney, S. Lam, and F. Gong, FEMS Microbiol. Lett. 134:299-307, 1995). A 2.2-kb region of the 30-84 chromosome which fully restored production of all of these compounds in strain 30-84W was identified. Nucleotide sequence analysis of this region revealed a single open reading frame encoding a predicted 213-amino-acid protein which is very similar to the global response regulator GacA. Strain 30-84.A2 was not complemented by gacA or any cosmid from a genomic library of strain 30-84 but was complemented by gacS (formerly lemA) homologs from Pseudomonas fluorescens Pf-5 (N. Corbel and J. E. Loper, J. Bacteriol. 177:6230-6236, 1995) and Pseudomonas syringae pv. syringae B728a (E. M. Hrabek and D. K. Willis, J. Bacteriol. 174:3011-3020, 1992). Transcription of phzR was not altered in either mutant; however, phzI transcription was eliminated in strains 30-84W and 30-84.A2. These results indicated that the GacS/GacA two-component signal transduction system of P. aureofaciens 30-84 controls the production of AHL required for phenazine production by mediating the transcription of phzI. Addition of exogenous AHL did not complement either mutant for phenazine production, indicating that the GacS/GacA global regulatory system controls phenazine production at multiple levels. Our results reveal for the first time a mechanism by which a two-component regulatory system and an AHL-mediated regulatory system interact.
Structure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) (2008)

Small molecules designed to mimic the binding of Smac protein to X-linked inhibitor of apoptosis protein (XIAP) are being pursued as a promising new class of anticancer drugs. Herein, we report the design, synthesis, and comprehensive structure-activity relationship studies of a series of conformationally constrained bicyclic Smac mimetics. Our studies led to the discovery of a number of highly potent and cell-permeable Smac mimetics and yielded important new insights into their structure-activity relationship for their binding to XIAP and for their activity in inhibition of cancer cell growth. Determination of the crystal structure of one potent Smac mimetic, compound 21, in complex with XIAP BIR3 provides the structural basis for its high-affinity binding to XIAP and for the design of highly potent Smac mimetics.
Direct Manipulation Interfaces (1985)

Direct manipulation has been lauded as a good form of interface design, and some interfaces that have this property have been well received by users. In this article we seek a cognitive account of both the advantages and disadvantages of direct manipulation interfaces. We identify two underlying phenomena that give rise to the feeling of directness. One deals with the information processing distance between the user's intentions and the facilities provided by the machine. Reduction of this distance makes the interface feel direct by reducing the effort required of the user to accomplish goals. The second phenomenon concerns the relation between the input and output vocabularies of the interface language. In particular, direct manipulation requires that the system provide representations of objects that behave as if they are the objects themselves. This provides the feeling of directness of manipulation.
Supercontinuum Generation in Silica Fibers by Amplified Nanosecond Laser Diode Pulses (2007)

Supercontinuum (SC) with a continuous spectrum from ~0.8-3 mum is generated in a standard single-mode fiber followed by high-nonlinearity fiber. The SC is pumped by 2-ns laser diode (LD) pulses amplified in a multistage fiber amplifier, and the two octave spanning continuum is achieved by optimizing a two-stage process that separates pulse breakup and soliton formation from spectral broadening. We also demonstrate scalability of the average power in the continuum from 27 mW to 5.3 W by increasing the pulse repetition rate from 5 kHz to 1 MHz, while maintaining comparable peak power. We attribute the generated SC spectrum to the ensemble average of multiple solitons and the superposition of their corresponding spectra. The hypothesis is confirmed through simulation results obtained by solving the generalized nonlinear Schrodinger equation (NLSE). Similar SC spectra can also be obtained by using both femtosecond and nanosecond pump pulses. Furthermore, by tailoring the input pulse shape, we propose and simulate the generation of the entire SC spectrum in one single soliton under quasi-continuous-wave (CW) pulse pumping scheme.
Simplified Hepatitis C Virus Genotyping by Heteroduplex Mobility Analysis (2000)

Heteroduplex mobility analysis (HMA) was used to genotype hepatitis C viruses (HCV) with PCR fragments derived from the 5' untranslated region (5'-UTR) or the NS5b region. HCV 5'-UTR fragments were amplified from 296 serum samples by use of a combined reverse transcription-PCR assay, and the genotypes of isolates were determined by sequencing. HCV genotype distributions in Australia were 39% for genotype 1a, 15% for 1b, 3% for 1a/b, <1% for 2a/c, 5% for 2b, 34% for 3a, <1% for 3b, and 1% for 4, and 1% of patients were infected with more than one genotype. Pairwise HMA of subtypes 1a, 1b, 2a/c, 2b, 3a, 3b, 4a, and 6a demonstrated that five distinct heteroduplex patterns were formed between the eight subtypes. A reference panel that contained a representative of each pattern (1a, 2b, 3a, 4a, and 6a) was used for genotyping. The pattern of heteroduplexes formed when a test isolate was mixed with the five reference isolates was correlated with the genotype, as determined by sequencing. Genotypes determined by HMA correlated exactly with sequencing results within the groups 1, 2, 3a, 3b/4, and 6. HMA was also used to simplify the identification of mixed infection with two HCV genotypes. In further studies, with amplicons from the NS5b region, HMA classified isolates into their respective subtypes, and the heteroduplex mobility ratio correlated closely with nucleotide sequence variation at the isolate, subtype, and genotype levels. HMA provides an adaptable, inexpensive, and rapid method of genotyping HCV that requires fewer resources than DNA sequencing.
Pharmacokinetics, Metabolism, and Oral Bioavailability of the DNA Methyltransferase Inhibitor 5-Fluoro-2′-Deoxycytidine in Mice (2006)

FdCyd is well absorbed but undergoes substantial first-pass catabolism by CD to potentially toxic metabolites that do not inhibit DNA methyltransferase. THU is sufficiently bioavailable to reduce the first-pass effect of CD on FdCyd. Oral coadministration of THU and FdCyd is a promising approach that warrants clinical testing because it may allow maintaining effective FdCyd concentrations on a chronic basis, which would be an advantage over other DNA methyltransferase inhibitors that are currently approved or in development.
Physicochemical characteristics of liposomes formed with internal wool lipids (1996)

Abstract The bilayer‐forming capability of internal wool lipids and their physicochemical properties were studied in an attempt to enhance our understanding of the lipid structure, present in wool and other keratinized tissues. Internal wool lipids were extracted and analyzed, and the mixture obtained [sterol esters (10%), free fatty acids (24%), sterols (11%), ceramides (46%), and cholesteryl sulfate (9%)] was shown to form stable liposomes. A phase‐transition temperature of 60°C was obtained from nuclear magnetic resonance spectra for this lipid mixture. The spontaneous permeability of these vesicles was lower than that of phosphatidylcholine liposomes but slightly higher than that of the vesicles formed with lipids extracted from other keratinized tissues with higher amounts of cholesterol. The transmission electron micrographs showed large vesicular aggregates of approximately 300 nm, which seem to be made up of smaller structures of approximately 20 nm in size. This particular structure could account for the large diameters and small internal volumes found by dynamic light‐scattering and spectrofluorometric measurements.
Rapid real time PCR to distinguish between high risk human papillomavirus types 16 and 18 (2001)

Real time PCR is a rapid, efficient method for the detection of HPV with the separation of HPV-16 and HPV-18 on the basis of differential Tm. Preliminary results suggest it could prove
Effect of the Repartitioning Agent Cimaterol on Growth, Carcass and Skeletal Muscle Characteristics in Lambs (1987)

Ten crossbred (Suffolk X Rambouillet) whether lambs were randomly assigned to receive 0 or 10 ppm cimaterol (CIM) in a completely mixed high-concentrate diet for 8 wk. Total weight gain and feed efficiency were improved 29% (P less than .05) and 14%, respectively, in the CIM-fed group. CIM also improved (P less than .01) dressing percent by 4.9 percentage points and improved yield grade by one grade. CIM increased longissimus muscle (LD) area 38% (P less than .01) and the yield of four lean cuts 28% (P less than .01). No difference was found in the proportion of type I (slow-contracting, oxidative) and type II (fast-contracting, mixed glycolytic/oxidative) fibers in LD and semitendinosus (ST) muscles between control and CIM groups, indicating no change in fiber type. The cross-sectional area of type II fibers in LD and ST muscles of the CIM group was 2,081 and 1,951 micron 2 as compared with 1,391 and 1,296 micron2 of the control group, respectively. The increase was approximately 50% (P less than .01). No difference was found in cross-sectional area of type I fibers, indicating that the increase of muscle mass was due to hypertrophy of type II fibers only. DNA concentration (micrograms/g wet muscle or microgram/g protein) of CIM muscle was much lower (P less than .01) than that of control muscle, suggesting that the protein accretion in muscle was accomplished without additional incorporation of nuclei from satellite cells.
Lethal infection by Bordetella pertussis mutants in the infant mouse model (1989)

Different aspects of lethal infection of infant mice with Bordetella pertussis were examined. Mutants deficient in vir-regulated genes were tested for the ability to cause a lethal infection in the infant mouse model. Adenylate cyclase toxin-hemolysin and pertussis toxin were required to cause a lethal infection at low doses. Mixed infection caused by challenging the mice with an equal number of pertussis toxin and adenylate cyclase toxin-hemolysin mutants at a dose at which neither alone was lethal was also unable to cause a lethal infection. Production of the filamentous hemagglutinin and the dermonecrotic toxin was not required to cause a lethal infection. Nine other mutants in vir-regulated genes whose phenotypes have yet to be determined were also tested. Only two of these mutants were impaired in the ability to cause a lethal infection. Expression of fimbriae does not appear to affect the dose required to cause a lethal infection; however, fimbrial expression was correlated with the later stages of a nonlethal, persistent infection. Growth of the bacteria in MgSO4, a condition which reversibly suppresses expression of the genes required for virulence, did not alter the ability of the bacteria to cause a lethal infection. Auxotrophic mutants deficient in leucine biosynthesis were as virulent as the parental strain; however, mutants deficient in methionine biosynthesis were less virulent. A B. parapertussis strain was much less effective in promoting a lethal infection than any of the wild-type B. pertussis strains examined. A persistent infection in the lungs was observed for weeks after challenge for mice given a sublethal dose of B. pertussis, and transmission from infected infants to the mother was never observed.
The Basic Helix-Loop-Helix Transcription Factor HESR1 Regulates Endothelial Cell Tube Formation (2001)

Human endothelial cells can be induced to form capillary-like tubular networks in collagen gels. We have used this in vitro model and representational difference analysis to identify genes involved in the formation of new blood vessels. HESR1 (HEY-1/HRT-1/CHF-2/gridlock), a basic helix-loop-helix protein related to the hairy/enhancer of split/HES family, is absent in migrating and proliferating cultures of endothelial cells but is rapidly induced during capillary-like network formation. HESR1 is detectable in all adult tissues and at high levels in well vascularized organs such as heart and brain. Its expression is also enriched in aorta and purified capillaries. Overexpression of HESR1 in endothelial cells down-regulates vascular endothelial cell growth factor receptor-2 (VEGFR2) mRNA levels and blocks proliferation, migration, and network formation. Interestingly, reduction of expression of HESR1 by antisense oligonucleotides also blocks endothelial cell network formation in vitro. Finally, HESR1 expression is altered in several breast, lung, and kidney tumors. These data are consistent with a temporal model for HESR1 action where down-regulation at the initiation of new vessel budding is required to allow VEGFR2-mediated migration and proliferation, but re-expression of HESR1 is necessary for induction of tubular network formation and continued maintenance of the mature, quiescent vessel.
Over-Generative Finite State Transducer N-Gram for Out-of-Vocabulary Word Recognition (2014)

Hybrid statistical grammars both at word and character levels can be used to perform open-vocabulary recognition. This is usually done by allowing the special symbol for unknown-word in the word-level grammar and dynamically replacing it by a (long) n-gramat character-level, as the full transducer does not fit in the memory of most current computers. We present a modification of a finite-state-transducer (fst) n-gram that enables the creation of a static transducer, i.e. when it is not possible to perform on-demand composition. By combining paths in the "LG" transducer (composition of lexicon and n-gram)making it over-generative with respect to the n-grams observed in the corpus, it is possible to reduce the number of actual occurrences of the character-level grammar, the resulting transducer fits the memory of practical machines. We evaluate this model for handwriting recognition using the RIMES and the IAM dabases. We study its effect on the vocabulary size and show that this model is competitive with state-of-the-art solutions.
Role of the tongue base suspension suture with The Repose System bone screw in the multilevel surgical management of obstructive sleep apnea (2002)

The Repose System in conjunction with UPPP has been shown to produce significant reductions in the RDI and apnea index as well as a significant increase in O2 saturation. Despite the improvement in these objective parameters, the overall surgical cure rate was only 20% (3 of 15 patients) in this retrospective series. Further research is warranted to define the role of The Repose System in the management of obstructive sleep apnea patients with multilevel airway obstruction.