gebhart/patrepeval huggingface dataset:
Regularization Paths for Generalized Linear Models via Coordinate Descent (2010)

We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, two-class logistic regression, and multi- nomial regression problems while the penalties include ℓ<sub>1</sub> (the lasso), ℓ<sub>2</sub> (ridge regression) and mixtures of the two (the elastic net). The algorithms use cyclical coordinate descent, computed along a regularization path. The methods can handle large problems and can also deal efficiently with sparse features. In comparative timings we find that the new algorithms are considerably faster than competing methods.
A Novel Electrolyte Solvent for Rechargeable Lithium and Lithium‐Ion Batteries (1996)

We describe a new type of electrolyte solvent which provides remarkable improvement in properties of electrolyte systems containing it. These solvents contain acidic boron atoms, in most cases linked into heterocycles by reaction of boric acid, or oxide, with glycols. Nicknamed BEG solvents (for boric acid esters of glycol), these show great propensity for dissolving salts, stabilizing alkali metals against corrosion, and in some cases, stabilizing other solvents (particularly alkene carbonates), against anodic decomposition. In the most favorable case so far, the 1,3 propylene glycol boric acid ester (BEG‐1) which contains two linked borate groups, the mixed solvent formed by mixing 1 part BEG‐1 with two parts ethylene carbonate provides an electrochemical stability window in excess of 5.8 V (cf. 4.5 V for ethylene carbonate alone with the same salt), an ambient temperature conductivity of with 1 m , and enduring stability against metallic Li, which remains shiny on prolonged (days) immersion at 100°C. We present data on various electrolyte solutions containing these components and then show their utility in devices by rubberizing them with polymers and constructing voltaic cells Li/, which show excellent charge/discharge characteristics and cyclability.
Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10. (1993)

Interleukin 10 (IL-10) is a pleiotropic factor that enhances proliferation of activated human B lymphocytes and induces them to secrete high amounts of immunoglobulins. Here we show that several human B cell lines were able to constitutively secrete human (h)IL-10. Whereas none of the pre-B nor the plasmocytic cell lines tested produced hIL-10, 25 of the 36 tested mature B cell lines (lymphoblastoid and Burkitt lymphoma cell lines) secreted hIL-10. Moreover, 24 of these 25 hIL-10-producing B cell lines contained the Epstein-Barr virus (EBV) genome, suggesting a relationship between hIL-10 production by human B cell lines and EBV expression. Accordingly, whereas polyclonal activation via triggering of surface immunoglobulins or CD40 antigen induced highly purified normal human B lymphocytes to produce only low (0.3-0.4 ng/ml) but significant amounts of hIL-10, EBV infection induced them to secrete high amounts of hIL-10 (4-9 ng/ml). Furthermore, addition of exogenous hIL-10, simultaneously to EBV infection, potentiated cell proliferation, whereas a blocking anti-IL-10 antiserum inhibited it. Thus, hIL-10 produced by infected human B lymphocytes appears to be involved in the mechanisms of EBV-induced B cell proliferation.
Genetic Modification of Homeostatic Regulation in the Mouse (1971)

A single genotype in the mouse, Avy/a, induces a continuum of coat color phenotypes ranging from clear yellow through all degrees of intermixture of yellow, black, and agouti hairs to complete agouti. This range of phenotypes can be divided into two physiologically distinct classes, mottled yellow and agouti. The proportion of the agouti phenotype among Avy/a mice is determined by the background genotype and varies from 12%-58% among the stocks observed. Mottled yellow Avy/a mice exhibit higher serum insulin levels, maintain the same rate of liver weight gain in spite of castration, stimulate growth of allogeneic tumor cells, and gain weight more rapidly than black a/a mice. In contrast, the agouti Avy/a mice resemble their black a/a sibs in these attributes. These and other data suggest that the agouti locus may affect the concentration of a regulatory entity of importance in many metabolic processes. While the basic concentration of this factor is probably determined by the strain genome, mutations at the agouti locus appear to alter it.
Preparation of Fluorescence Tunable Polymer Nanoparticles by One-step Mini-emulsion (2010)

Fluorescence tunable polymer nanoparticles were prepared by incorporating two hydrophobic fluorescent dyes (9, 10-diphenylanthracene: DPA and nitrobenzoxadiazolyl: NBD) into polymethylmethacrylate (PMMA) nanoparticles via one-step mini-emulsion polymerization method. The prepared fluorescent nanoparticles exhibit the spectral properties of both DPA and NBD dye, indicating that the two fluorophores have been incorporated into the nanoparticles. The nanoparticles greatly enhance the fluorescence emission of the two hydrophobic dyes in aqueous media probably by providing good protection of the dye molecules in the polymer nanoparticles matrix. Moreover, by varying the doping ratio of the two hydrophobic dyes, the polymer nanoparticles exhibit tunable and distinguishable emission characteristics under a single wavelength excitation via occuring fluorescence resonance energy transfer (FRET).
Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. (1980)

The in vitro growth characteristics and morphology of human retinal pigment epithelium (RPE) cells from adult donor eyes (15 to 100 years of age) have been studied. Although RPE cells are viable in culture for several months, only a fraction of the cells actually divide. Rapid cell proliferation and confluency of a culture occur from 10 to 30 days after seeding. The time for confluency is both age- and media-dependent; the number of cells that are potential dividers and contribute to confluency decreases with increasing donor age. Since melanolipofuscin granules do not form in vitro and are diluted by cell division, stationary (nondividing) cells can be distinguished from the dividing cells by the presence of dense clusters of melanolipofuscin granules in the stationary cells. Confluent cultures contain a monolayer of relatively clear polygonal cells with densely pigmented stationary cells scattered throughout. Stationary cells can often represent as much as 95% of the original RPE cell population. Ultrastructurally all cells appear epithelioid, with apical-basal polarity, junctional complexes, and cytoplasmic organization characteristic of RPE cells in vivo. Stationary cells are extremely large, with melanolipofuscin granules clustered around the nucleus. Melanolipofuscin is a unique marker for nondividing cells and may facilitate studies of the age-dependent loss of replicability of human RPE.
The Feedback Control Mechanism of Biosynthetic L-Threonine Deaminase by L-Isoleucine (1961)

"Man does not realize how that which varies is a unity. There is a harmony of opposite tensions as there is one of bow and lyre."
Inhibitory Effects of Some Traditional Medicines on Proliferation of HIV-1 and Its Protease (2004)

In attempts to discover anti-HIV agents from natural sources, various traditional medicine extracts were tested for their inhibitory effects on HIV-1 proliferation and its protease. An extract of the seeds of Croton tiglium showed potent inhibitory effects on the proliferation of HIV-1. The active principle was determined to be phorbol esters. Several derivatives of phorbol ester were evaluated for inhibition of proliferation as well as activation of protein kinase C (PKC). Of these compounds, 12-O-acetylphorbol 13-decanoate (6) showed the most potent inhibition of proliferation without activating PKC. Some triterpenes from the stems of Cynomorium songaricum and the woody part of Xanthoceras sorbifolia showed inhibitory activity against HIV-1 protease. Various derivatives of oleanolic acid were synthesized and evaluated for their inhibitory activity against HIV-1 protease. Their inhibitory mechanism was also investigated.
Dynamic graph-based software fingerprinting (2007)

Fingerprinting embeds a secret message into a cover message. In media fingerprinting, the secret is usually a copyright notice and the cover a digital image. Fingerprinting an object discourages intellectual property theft, or when such theft has occurred, allows us to prove ownership. The Software Fingerprinting problem can be described as follows. Embed a structure W into a program P such that: W can be reliably located and extracted from P even after P has been subjected to code transformations such as translation, optimization and obfuscation; W is stealthy; W has a high data rate; embedding W into P does not adversely affect the performance of P ; and W has a mathematical property that allows us to argue that its presence in P is the result of deliberate actions. In this article, we describe a software fingerprinting technique in which a dynamic graph fingerprint is stored in the execution state of a program. Because of the hardness of pointer alias analysis such fingerprints are difficult to attack automatically.
Hsp90 inhibitors deplete key anti‐apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin (2004)

Abstract Drugs that inhibit the function of heat shock protein 90 (Hsp90) are of interest in the treatment of pediatric cancers because these agents deplete the cellular levels of signaling molecules that are important for the growth and survival of many childhood tumors. To generate preclinical data in anticipation of clinical trials of Hsp90 inhibitors in children, we evaluated the effects of the Hsp90 inhibitor geldanamycin (GA) alone and in combination with cis ‐platinum (II)‐diamine dichloride (cisplatin) in pediatric tumor cells. Immunoblotting demonstrated depletion of the Hsp90 client proteins AKT and the type 1 insulin‐like growth factor receptor (IGF1R) in a panel of pediatric tumor cell lines after exposure to GA. Drug exposure also led to a dramatic decrease in cell survival/proliferation in MYCN ‐amplified and non‐amplified neuroblastoma cells. Moderate inhibition of survival/proliferation was observed in RB ‐deficient and wild‐type osteosarcoma cells. Treatment of neuroblastoma and osteosarcoma cell lines with GA in combination with cisplatin resulted in greater than additive inhibition of survival/proliferation based on median dose analysis. Exposure to this drug combination also resulted in a marked increase in nuclear fragmentation as assessed by terminal deoxynucleotide transferase‐mediated UTP nick end labeling (TUNEL) analysis. Combined exposure also abrogated the ability of GA to induce a cytoprotective heat shock response and resulted in Hsp90 adduct formation. Our findings suggest that Hsp90 inhibitors may prove useful either alone or as a component of multi‐drug regimens in the treatment of neuroblastoma and osteosarcoma.
Natural human antibodies to gamma interferon interfere with the immunomodulating activity of the lymphokine. (1992)

Natural antibodies to gamma interferon (IFN-gamma) were found in patients suffering from different viral diseases and, at a lower titer, in healthy individuals. Such antibodies were affinity-purified and studied for their capability to interfere in vitro with the antiviral and immunomodulating activity of IFN-gamma. Data obtained show that these human anti-IFN-gamma antibodies have no inhibitory effect on the antiviral activity of IFN-gamma. On the contrary, they are able to inhibit the expression of Fc receptor sites and HLA-DR antigens induced by IFN-gamma on the U-937 cells, a human monocytoid/macrophage-derived cell line. These antibodies can also interfere in a mixed lymphocyte culture (MLC) with the proliferation of lymphocytes and the generation of cytotoxic lymphocytes. However, they showed only a moderate inhibitory effect on the cytotoxicity generated in MLC to K-562 cells. Human antibodies capable of interfering with the immunomodulating activities of IFN-gamma might open up a new field in clinical therapy for those diseases that carry evidence of activated cell-mediated immunity.
Ultrasensitive Fluorogenic Substrates for Serine Proteases (1997)

Selective, sensitive assays for the quantitation of serine proteases involved in coagulation and fibrinolysis have been developed employing fluorogenic substrates containing a 6-amino-1-naphthalenesulfonamide leaving group (PNS-substrates). Over one hundred substrates were evaluated for hydrolysis by the serine proteases of blood coagulation and fibrinolysis, and substrate structure-efficiency correlations were examined. PNS-substrates which contain Lys in the P1 position are specific for Lys-plasmin and are either not hydrolyzed or hydrolyzed at a relatively low rate by factor Xa, thrombin, or urokinase-type plasminogen activator (uPA). These substrates allow quantitation of Lys-plasmin at concentrations as low as 1 pM. Eighteen of over 90 substrates tested for factor XIa are hydrolyzed by this enzyme at a relatively high rate reaching a k(cat), value of 170 s(-1) and allowing quantitation of factor XIa at 10 fM. Eighteen of almost 90 PNS-substrates tested display high specificity for thrombin, some exceeding that for factor Xa by >10,000-fold and >100-fold for activated protein C (APC). Seven of these substrates have a k(cat) over 100 s(-1) and three of them have a K(M) below 1 microM. They allow the quantitation of thrombin at concentrations as low as 20 fM. For APC, uPA and the factor VIIa/tissue factor complex, quantitation is feasible at 1 pM concentration. For factor Xa and factor VIIa the limits are 0.4 pM and 40 pM respectively. The PNS-substrates presented in this study may be employed for the development of direct and sensitive serine protease assays.
Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. (1995)

We have determined the relationships between busulfan average concentration at steady-state and (1) rejection of graft, and (2) regimen-related toxicity, and have evaluated the dependence of busulfan clearance/F on body size and age. Patients received 16-30 mg/kg of busulfan followed by cyclophosphamide in doses of 120, 150, 174, or 200 mg/kg or 8 g/m2 in preparation for autologous, syngeneic or allogeneic grafts varying in compatibility from HLA-matched siblings to HLA-partially-matched unrelated donors. In a multivariate Cox time-to-rejection analysis, only busulfan concentration remained a significant determinant of rejection, P = 0.0154. An average concentration of busulfan at steady-state of at least 200 ng/ml was needed to avoid rejection of a matched-sibling graft, while 600 ng/ml was needed to avoid rejection of HLA-partially-matched related or HLA-matched unrelated donor grafts. The toxicity of the cytoreductive regimen correlated with busulfan average concentration at steady-state (rs = 0.717). Busulfan clearance/F expressed relative to body weight, ideal body weight or surface area declined with age during the first decade of life. Over the entire span of age, the coefficient of variation in clearance/F for all ages was similar when clearance/F was expressed in absolute terms (ml/min) and when adjusted for body surface area; the coefficient of variation was greater for clearance/F when expressed relative to total or ideal body weight. We conclude that busulfan concentration in plasma is an important determinant of graft survival and regimen-related toxicity, and that the variability of busulfan pharmacokinetics with age precludes the use of a fixed dose for all ages and indications.
CYCLODIALYSIS WITH INSERTION OF A METAL IMPLANT IN THE TREATMENT OF GLAUCOMA (1940)

Since Heine devised cyclodialysis (1905) the operation has been tried extensively by many surgeons. It has been called an internal fistulization in the belief that it creates a direct internal channel between the anterior chamber and the suprachoroidal space. Its action is opposed to external fistulization, in which the anterior chamber is made to communicate with the subconjunctival spaces outside of the eye by a trephine or a Lagrange operation. Cyclodialysis is preferred by some surgeons because it is harmless and free from the dangers of secondary infection. Unfortunately its effects in relieving hypertension are almost always temporary. A permanent result is obtained in only about 20 per cent of the cases. The great number of failures has been ascribed to an earlier and complete cicatrization of the detached scleral insertion of the ciliary body to the scleral spur, which reattaches itself, blocking the aperture between the anterior chamber and
Characterization of Protein Adsorption and Immunosorption Kinetics in Photoablated Polymer Microchannels (2000)

A preliminary characterization of protein adsorption and immunosorption kinetics carried out in polymer microchannels is reported. A photoablated poly(ethylene terephthalate) (PET) surface and a PET/polyethylene sealing laminate were used for the channel microfabrication. The surface state of the PET channel substrate and PET/polyethylene lamination were analyzed by using SEM and ATR-FTIR spectroscopy techniques. Protein adsorption and immunosorption studies were carried out using staphylococcal enterotoxin B (SEB) and polyclonal anti-SEB antibody (Ab) samples. Affinity purified polyclonal rabbit (Rb) anti-SEB Ab was radioiodinated and adsorbed in the microchannel. It was determined that the maximum amount of adsorbed antibody was about 13.0 pmol·cm-2 (about 2 μg·cm-2), which corresponds to 0.81 pmol per microchannel. The distribution of the adsorbed protein on the walls of the microchannel depended on the surface state of the polymer exposed to the solution. The amount of the radiolabeled antibody adsorbed on the photoablated PET was about 19.4 pmol·cm-2, whereas it was only 5.5 pmol·cm-2 on the PET/polyethylene lamination. About 30% of the anti-SEB Ab adsorbed on the microchannel surface was found to be biologically active. A study of the kinetics of the SEB−anti-SEB Ab immunochemical reaction was also carried out. It could be substantiated that the forward reaction is diffusion controlled and that the equilibrium for such a reaction could be achieved within about 1 min in the microchannels. This is in good agreement with the calculation of a diffusion-controlled reaction in such a microchannel, according to Fick's second law.
Synthesis of Triketide δ-Lactones (2001)

An efficient synthetic route was developed to prepare substituted δ-lactones 1 and 2 in enantiopure forms which are potentially useful for biosynthetic studies with genetically engineered modular polyketide synthase (PKS). The key step to prepare the target epimeric lactones involves the samarium(II) iodide-mediated Reformatsky reaction.
Forecasting a Storm: Divining Optimal Configurations using Genetic Algorithms and Supervised Learning (2019)

With the advent of Big Data platforms like Apache Storm, computations once deemed infeasible locally become possible at scale. However, doing so entails orchestrating powerful yet expensive clusters. With its focus on stream processing, Storm optimizes for low-latency and high throughput. However, to realize this goal and thereby maximize the utility of these clusters' resources, operators must execute these tasks under their optimal configurations. Yet, the search space for finding such configurations is so vast and time-consuming to explore so as to be effectively intractable due to issues like the temporal overhead of testing new candidate configurations, the sheer number of permutations of parameters within each configuration and their interdependence among each other. In order to efficiently cover the search space, we automate the process with genetic algorithms. Moreover, we fuse this technique not only with additional cluster information gleaned from JMX profiling and Storm performance data but also with classifiers constructed from training data from past executions of a plethora of Storm topologies. Utilizing a diverse set of Storm benchmark topologies as evaluation data, we show that the fully enhanced genetic algorithms can efficiently find configurations that perform on average 4.67× better than "rules of thumb"-derived manual baselines. Moreover, we demonstrate that our fully refined classifiers enhance the GA throughput on average across the topologies by 22% while reducing search time by a factor of 6.47×.
Treinta años de estudios sobre la historia de empresas en la Argentina (1995)

AIT is accepted to be the only causative treatment option for allergies. New application routes in ILIT and EPIT may become more important and allow for different delivery methods in the future, however further clinical studies are required and in preparation.
Deterministic Replay of Multithread Applications Using Virtual Machine (2012)

The deterministic replay technology usually is used to reproduce non-deterministic failures, especially the concurrency failures which are hard to debug with cyclic-debugging techniques. Previous techniques either incur large overhead or require custom hardware extensions. They have also suffered from the interference with irrelevant processes. This paper introduces WDRVirt, a new software based replay system that provides deterministic replay for concurrent applications. This paper makes three contributions. First, WDRVirt enforces a deterministic replay for the interleaving of lock acquisitions with low performance overhead. Second, different from the previous works, we customize the lightweight virtual machine execution environment as the container for the target program. WDRVirt replays the container to avoid the interference with other irrelevant processes. At last, WDRVirt is deployed into both virtual machine(VM) and virtual machine manager(VMM) to deal with different types of non-deterministic event. We have implemented this system based on the Xen virtualization platform. Our experiments with real-world benchmarks demonstrate the effectiveness of WDRVirt.
Tocilizumab: A humanized anti-IL-6 receptor monoclonal antibody for the treatment of rheumatoid arthritis (2008)

Tocilizumab, an investigational agent for the treatment of moderate-to-severe rheumatoid arthritis, is a humanized anti-IL-6 receptor monoclonal antibody. Because tocilizumab contains a mouse monoclonal antibody grafted onto human immunoglobulin, the grafted antibody is less antigenic and has a longer half-life than the mouse antibody. When administered, tocilizumab inhibits IL-6 activity by competing for both the membrane-bound and soluble types of IL-6 receptors, thus eliminating IL-6 transduction into the cell.