gebhart/patrepeval huggingface dataset:
Single-chip fused hybrids for acousto-electric and acousto-optic applications (1997)

The combination of the electronic and optical properties of a semiconductor hetero-junction and the acoustic properties of a piezoelectric substrate material yields a new class of very promising hybrids for potential acousto-electric and acousto-optic applications. LiNbO3/GaAs hybrids have been fabricated using the epitaxial lift-off technique resulting in unusually large acousto-electric and acousto-optic interaction between the quasi two-dimensional electron system in the semiconductor and surface acoustic waves on the piezoelectric substrate. Field effect tunability of the interaction at room temperature is demonstrated and possible device applications are discussed. Photoluminescence measurements show the influence of the acousto-electric fields on the optical properties of quantum well structures.
Synthesis, reactivity, molecular structure, and catalytic activity of the novel dichlorodihydridoosmium(IV) complexes OsH2Cl2(PR3)2 (PR3 = P-i-Pr3, PMe-t-Bu2) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, reactivity, molecular structure, and catalytic activity of the novel dichlorodihydridoosmium(IV) complexes OsH2Cl2(PR3)2 (PR3 = P-i-Pr3, PMe-t-Bu2)M. Aracama, M. A. Esteruelas, F. J. Lahoz, J. A. Lopez, U. Meyer, L. A. Oro, and H. WernerCite this: Inorg. Chem. 1991, 30, 2, 288–293Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/ic00002a025https://doi.org/10.1021/ic00002a025research-articleACS PublicationsRequest reuse permissionsArticle Views545Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non–Small Cell Lung Cancer (2012)

Ganetespib has greater potency than 17-AAG and potential efficacy against several NSCLC subsets, including those harboring EGFR or ERBB2 mutation.
Conversion of 2-chloroallylamines into heterocyclic compounds. Part I. 2-Methylindoles,1,5,6,7-tetrahdyro-3-methylindol-4-ones, and related heterocycles (1975)

Heating several N-(2-chloroallyl)anilines with polyphosphoric acid at 100 °C or with boron trifluoride–methanol at 150 °C gave 2-methylindoles. 2-Methyloxazolo[3,2-a]quinolin-5-one, imidazo[1,2-a]pyridine, and 2-methyl-pyrrolo[3,2-c]quinolines were similarly obtained from N-(2-chloroallyl)-4-hydroxyquinoline-2-one, 2-(2-chloroallylamino)pyridine and 4-[N-(2-chloroallyl)-ethylamino]- and -anilino]-quinolines, respectively. 1-Ethyl and 1-aryl-1,5,6,7-tetrahydro-3-methyl-6,6-dimethylindol-4-ones were obtained from the corresponding dimedone enamines on treatment with polyphosphoric acid. 3-Acetonyl-,4,6-trimethylaniline was obtained in excellent yield from N-(2-chloroallyl)-2,4,6-trimethylaniline.
Autologous bone marrow transplantation with monoclonal antibody purged marrow for high risk acute lymphoblastic leukemia. (1989)

Fifty-four patients with acute lymphoblastic leukemia (ALL: 1 relapse, 21 high risk first complete remission (CR 1), 29 second CR (CR 2), and 3 third CR (CR 3) were treated by autologous bone marrow transplantation at three centers. Before storage, the marrows were purged ex vivo with appropriate MAbs RFAL3 (CD10), SB4 (CD19), and RFT2 (CD7), with rabbit serum as the source of complement. All patients received total body irradiation either 750 cGy (middose 15 cGy/min) as a single fraction or 6 x 200 cGy over 3 days (midline dose 16 cGy/min) with lung shielding from 1,100 cGy. The patients who received 750 cGy also received cyclophosphamide or the same drug combined with ara-C or prednisone, teniposide, vincristine, ara-C, and dauno-rubicin. Patients receiving 200 cGy x 6 also received either cyclophosphamide, melphalan, or ara-C and cyclophosphamide. Three patients died of post transplantation complications (interstitial pneumonia, hepatitis B liver necrosis, or encephalitis). This gives a procedure related mortality of 5%. Nonfatal complications were 10 cases of septicemia, 4 interstitial pneumonia, 2 interstitial nephritis, 1 veno-occlusive disease (VOD), and 1 case of hemolytic uremic syndrome. The patient autografted in relapse died of relapse within 2 months. In CR 1 6 or 21 patients have had a relapse, and the actuarial leukemia free survival from CR is 65% (median follow-up 16 months). In CR 2-3 18 of 32 patients have relapsed, and the actuarial leukemia free survival is 31% (median follow-up 18.5 months) from CR. Twelve patients have achieved an inversion, (i.e., present CR longer than previous CR), with a further seven with the potential to achieve inversion. We conclude that ABMT in high risk ALL has a low procedure related mortality (5%), and there are few other complications. The in vitro purging with MAbs had no adverse effect on bone marrow reconstitution, but this study was not designed to demonstrate its antileukemic efficacy. The actuarial leukemia free survival time in the present study for patients with high risk CR 1 and the inversions in CF 2-3 are promising and indicate a potential beneficial effect of ABMT.
Mitsunobu and Related Reactions: Advances and Applications (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMitsunobu and Related Reactions: Advances and ApplicationsK. C. Kumara Swamy*, N. N. Bhuvan Kumar, E. Balaraman, and K. V. P. Pavan KumarView Author Information School of Chemistry, University of Hyderabad, Hyderabad − 500046, A. P., India* To whom correspondence should be addressed. E-mail: [email protected] or [email protected]Cite this: Chem. Rev. 2009, 109, 6, 2551–2651Publication Date (Web):April 21, 2009Publication History Received30 July 2008Published online21 April 2009Published inissue 10 June 2009https://pubs.acs.org/doi/10.1021/cr800278zhttps://doi.org/10.1021/cr800278zreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views70610Altmetric-Citations977LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Cyclization,Ethers,Organic compounds,Reaction products Get e-Alerts
[Clinical significance of expression of enhancer of zeste homolog 2 and 53 in cervical squamous cell carcinoma and intraepithelial neoplasia]. (2014)

Both EZH2 and p53 proteins may play important roles in the occurrence and development of cervical squamous cell carcinoma. There is a close relationship between the expression of both EZH2 and p53 proteins and the prognosis of SCC patients.
Development of a Comprehensive Dietary Antioxidant Index and Application to Lung Cancer Risk in a Cohort of Male Smokers (2004)

In many observational studies, a higher intake of individual antioxidants is inversely associated with lung cancer risk. Data from in vitro and animal experiments suggest that there are biochemical interactions among antioxidant nutrients; therefore, consideration of multiple antioxidants simultaneously may be important in terms of risk estimation. The authors constructed a dietary antioxidant index and evaluated its ability to predict lung cancer risk within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. At baseline (1985-1988), 27,111 Finnish male smokers aged 50-69 years completed a dietary questionnaire that assessed usual frequency of consumption and portion sizes for the previous 12 months. A total of 1,787 incident cases of lung cancer were identified during a follow-up period of up to 14.4 years (1985-1999). Principal components analyses were individually applied to the carotenoid, flavonoid, and vitamin E nutrient groups, and summation of retained principal component scores, plus selenium and vitamin C, yielded the composite antioxidant index. In multivariate proportional hazards models, the relative risks for lung cancer according to increasing quintiles of the antioxidant index were 1.00 (referent), 1.00 (95% confidence interval (CI): 0.87, 1.14), 0.91 (95% CI: 0.79, 1.05), 0.79 (95% CI: 0.68, 0.92), and 0.84 (95% CI: 0.72, 0.98) (p for trend = 0.002). These findings support the hypothesis that a combination of dietary antioxidants reduces lung cancer risk in male smokers.
Internal Phase Breaker Technology for Viscoelastic Surfactant Gelled Fluids (2005)

Abstract Past viscoelastic surfactant (VES) gelled fluids used for fracpacking and conventional hydraulic fracturing have primarily relied on external or reservoir conditions to break (reduce) the fluids gel viscosity. This paper describes an internal phase breaker system developed for breaking viscoelastic surfactant gelled fluids. Laboratory rheological data is presented that shows controlled viscosity reduction can be achieved from 80°F to 225°F by the use of two or three aqueous breaker solutions. The mix waters evaluated were KCl, CaCl2, and ASTM synthetic seawater. The results show that break times typical for polymeric fluids can now be achieved for VES gelled fluids.
The integrin αvβ6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin (1998)

The integrin alphavbeta6 is expressed on a variety of epithelial cells during dynamic processes including organogenesis, tissue injury and malignant transformation. However, because of the lack of tools to specifically inhibit the function of this integrin, little is known about its effects on cell behavior. To directly examine the role of this integrin in cell migration, we used keratinocytes derived from wild-type mice or mice expressing a null mutation in the beta6 subunit (beta6-/-) to perform migration assays in vitro. Migration on the known alphavbeta6 ligand, fibronectin was reduced in keratinocytes from beta6-/- mice. Interestingly, keratinocytes from beta6-/- mice also demonstrated markedly reduced migration on vitronectin, a protein not previously known to be a ligand for alphavbeta6. An anti-alphavbeta6 monoclonal antibody 10D5, generated by immunization of beta6-/- mice with murine keratinocytes, inhibited adhesion and migration of wild-type keratinocyte on both vitronectin and fibronectin to levels similar to those seen with keratinocytes from beta6-/- mice. alphavbeta6-mediated migration on both ligands was dramatically augmented by treatment with phorbol myrisate acetate (PMA) or with hepatocyte growth factor, and augmentation of migration by either stimulus could be abolished by the PKC inhibitor GF109203X, suggesting a critical role for PKC in enhancement of alphavbeta6-mediated cell migration.
Extragastroduodenal conditions associated with Helicobacter pylori infection. (1999)

Helicobacter pylori is a Gram-negative bacterium that is considered a causative agent of peptic ulcer disease, gastric lymphoma, and gastric carcinoma. Helicobacter pylori triggers an intense leucocyte infiltration of the gastric submucosa, an action which is mediated by pro-inflammatory cytokines. This pathogenetic mechanism is common to many other diseases and consequently, Helicobacter pylori seroprevalence has also been investigated in other diseases. It is now known that Helicobacter pylori seropositivity is associated with various cardiovascular, respiratory, extragastroduodenal digestive, neurological, dermatological, autoimmune, and growth disorders. Although the precise role of Helicobacter pylori is unknown in these diseases, the organism can be eradicated using simple and reliable drug regimens. The conditions associated with Helicobacter pylori seropositivity are highlighted in this article.
Practical Implementation of Low-Frequency Equalization Using Adaptive Digital Filters (1994)

Adaptive digital filters have been used in an experimental investigation of low frequency equalization of a single channel sound reproduction system in a car. The problems are discussed of adapting the digital filter so that a smooth transition is achieved between the equalized low frequency response (below 400 Hz) and the unequalized high frequency response. Equalization of the response at only one point in the car is found to cause degradation in the response at others. Multiple point equalization, in which the response at four positions is best equalized in a least squares sense, was found to give only modelstt overall improvements in this case. The best strategy for a single filter appears to be weighted multiple point equalization, in which the error at the most important listening position in thecar is more heavily weighted in the adaptation algorithm
Reduction and alkylation of proteins in preparation of two-dimensional map analysis: Why, when, and how? (2001)

The standard procedure adopted up to the present in proteome analysis calls for just reduction prior to the isoelectric focusing/immobilized pH gradient (IEF/IPG) step, followed by a second reduction/alkylation step in between the first and second dimension, in preparation for the sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) step. This protocol is far from being optimal. It is here demonstrated, by matrix assisted laser desorption/ionization-time of flight (MALDI-TOF)-mass spectrometry, that failure to reduce and alkylate proteins prior to any electrophoretic step (including the first dimension) results in a large number of spurious spots in the alkaline pH region, due to "scrambled" disulfide bridges among like and unlike chains. This series of artefactual spots comprises not only dimers, but an impressive series of oligomers (up to nonamers) in the case of simple polypeptides such as the human alpha- and beta-globin chains, which possess only one (alpha-) or two (beta-) -SH groups. As a result, misplaced spots are to be found in the resulting two-dimensional (2-D) map, if performed with the wrong protocol. The number of such artefactual spots can be impressively large. In the case of analysis of complex samples, such as human plasma, it is additionally shown that failure to alkylate proteins results in a substantial loss of spots in the alkaline gel region, possibly due to the fact that these proteins, at their pI, regenerate their disulfide bridges with concomitant formation of macroaggregates which become entangled with and trapped within the polyacrylamide gel fibers. This strongly quenches their transfer in the subsequent SDS-PAGE step.
Pseudomonas aeruginosa mutants affected in anaerobic growth on arginine: evidence for a four-gene cluster encoding the arginine deiminase pathway (1984)

Pseudomonas aeruginosa PAO was able to grow in the absence of exogenous terminal electron acceptors, provided that the medium contained 30 to 40 mM L-arginine and 0.4% yeast extract. Under strictly anaerobic conditions (O2 at less than 1 ppm), growth could be measured as an increase in protein and proceeded in a non-exponential way; arginine was largely converted to ornithine but not entirely consumed at the end of growth. In the GasPak anaerobic jar (Becton Dickinson and Co.), the wild-type strain PAO1 grew on arginine-yeast extract medium in 3 to 5 days; mutants could be isolated that were unable to grow under these conditions. All mutants (except one) were defective in at least one of the three enzymes of the arginine deiminase pathway (arcA, arcB, and arcC mutants) or in a novel function that might be involved in anaerobic arginine uptake (arcD mutants). The mutations arcA (arginine deiminase), arcB (catabolic ornithine carbamoyltransferase), arcC (carbamate kinase), and arcD were highly cotransducible and mapped in the 17-min chromosome region. Some mutations in the arc cluster led to low, noninducible levels of all three arginine deiminase pathway enzymes and thus may affect control elements required for induction of the postulated arc operon. Two fluorescent pseudomonads (P. putida and P. fluorescens) and P. mendocina, as well as one PAO mutant, possessed an inducible arginine deiminase pathway and yet were unable to grow fermentatively on arginine. The ability to use arginine-derived ATP for growth may provide P. aeruginosa with a selective advantage when oxygen and nitrate are scarce.
Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. (1997)

The cell surface adhesion molecule MCAM (MUC18) is strongly expressed by advanced primary and metastatic melanomas but is weaker and less frequent in nevus cells. Previous studies have shown that MCAM expression correlates with tumor thickness and metastatic potential of human melanoma cells in nude mice. To provide direct evidence that MCAM plays a role in tumor growth and metastasis of human melanoma, the nonmetastatic MCAM-negative primary cutaneous melanoma SB-2 cells were transfected with MCAM cDNA and analyzed subsequently for changes in their tumorigenic and metastatic potential. Enforced expression of MCAM in SB-2 cells rendered them highly tumorigenic and increased their metastatic potential in nude mice as compared with parental and control transfected cells. The transfected cells displayed increased homotypic adhesion, increased attachment to human endothelial cells, decreased ability to adhere to laminin, and increased invasiveness through Matrigel-coated filters. Anti-MCAM monoclonal antibody reversed these functions in the transfected cells but not in control cells. The above changes in function attributed to the expression of MCAM may underlie the contribution of MCAM/MUC18 to the malignant phenotype.
The radiation condition at infinity for the high-frequency Helmholtz equation with source term: a wave packet approach (2008)

We consider the high-frequency Helmholtz equation with a given source term, and a small absorption parameter <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>α</mml:mi> <mml:mo>&gt;</mml:mo> <mml:mn>0</mml:mn> </mml:mrow> </mml:math> . The high-frequency (or: semi-classical) parameter is <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>ε</mml:mi> <mml:mo>&gt;</mml:mo> <mml:mn>0</mml:mn> </mml:mrow> </mml:math> . We let <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>ε</mml:mi> </mml:math> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>α</mml:mi> </mml:math> go to zero simultaneously. We assume that the zero energy is non-trapping for the underlying classical flow. We also assume that the classical trajectories starting from the origin satisfy a transversality condition, a generic assumption. Under these assumptions, we prove that the solution <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mi>u</mml:mi> <mml:mi>ε</mml:mi> </mml:msup> </mml:math> radiates in the outgoing direction, uniformly in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>ε</mml:mi> </mml:math> . In particular, the function <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mi>u</mml:mi> <mml:mi>ε</mml:mi> </mml:msup> </mml:math> , when conveniently rescaled at the scale <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>ε</mml:mi> </mml:math> close to the origin, is shown to converge towards the outgoing solution of the Helmholtz equation, with coefficients frozen at the origin. This provides a uniform (in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>ε</mml:mi> </mml:math> ) version of the limiting absorption principle. Writing the resolvent of the Helmholtz equation as the integral in time of the associated semi-classical Schrödinger propagator, our analysis relies on the following tools: (i) For very large times, we prove and use a uniform version of the Egorov Theorem to estimate the time integral; (ii) for moderate times, we prove a uniform dispersive estimate that relies on a wave-packet approach, together with the above mentioned transversality condition; (iii) for small times, we prove that the semi-classical Schrödinger operator with variable coefficients has the same dispersive properties as in the constant coefficients case, uniformly in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>ε</mml:mi> </mml:math> .
Antifreeze protein gene transfer in Atlantic salmon. (1993)

Salmonids freeze to death if they come into contact with ice. Many marine fish species that inhabit icy sea waters synthesize antifreeze proteins (AFP) to protect them from freezing. Production of stable lines of freeze-resistant salmon and other species would greatly facilitate development of sea-pen aquaculture in many regions. We successfully introduced winter flounder AFP genes into Atlantic salmon. Research to date indicates stable genomic integration and low levels of expression of winter flounder AFP genes in a small number (approximately 3%) of salmon developed from microinjected eggs. Inheritance of the AFP gene by offspring (F1) from crosses between transgenic and wild-type salmon revealed that the transgenic flounders (F0) were germ-line mosaics. Low levels of AFP precursors could be detected in the blood of all these transgenic offspring (F1). Approximately 50% of the progeny produced by crosses between transgenic F1 and wild-types contained the AFP genes. These results demonstrate that stable germ-line transformed Atlantic salmon can be produced.
Modern compressible flow, with historical perspective - 2nd Edition (1990)

Keywords: ecoulement : compressible ; chocs ; transsonique Reference Record created on 2005-11-18, modified on 2016-08-08
A Transmembrane Helix Dimer: Structure and Implications (1997)

The three-dimensional structure of the dimeric transmembrane domain of glycophorin A (GpA) was determined by solution nuclear magnetic resonance spectroscopy of a 40-residue peptide solubilized in aqueous detergent micelles. The GpA membrane-spanning alpha helices cross at an angle of -40 degrees and form a small but well-packed interface that lacks intermonomer hydrogen bonds. The structure provides an explanation for the previously characterized sequence dependence of GpA dimerization and demonstrates that van der Waals interactions alone can mediate stable and specific associations between transmembrane helices.