gebhart/patrepeval huggingface dataset:
Absorption of Estrogens from Vaginal Creams (1978)

INTRAVAGINAL application of estrogen-containing creams has been widely used in the treatment of vaginal atrophy and related conditions due to estrogen deficiency. Although its efficacy is well recognized,1 , 2 the assumed "topical" effect and the potential for absorption of estrogenic substances contained in the vaginal cream are virtually unexplored.Recent observations indicate that the efficacy of absorption of micronized 17β-estradiol yields blood estradiol levels 100 times higher when administered intravaginally in salines than when given by mouth.3 , 4 Moreover, the substantial intestinal conversion of estradiol to estrone, observed after oral administration of estradiol,3 is circumvented by intravaginal application. These findings prompted us . . .
关于邢公畹教授对拙作《汉语南岛语同源论》的述评 (1992)

199o年在德克萨斯州举行的第23届汉藏语会上我宣读了一篇题为“Chinese and Aus-tronesian are genetically related”(《汉语南岛语同源论》)的论文,曾寄给邢公畹教授一份,请他指正。没想到邢教授那么重视,写了一篇长的文章,陆续登在《民族语文》1991第3,4,5期(下文称为“邢文Ⅰ,Ⅱ,Ⅲ”,后面的阿拉伯数字为页码),为拙作进行述评、补证。邢教授将拙作介绍给中国读者使我感到非常荣幸,在此特向邢教授表示
SNP frequency, haplotype structure and linkage disequilibrium in elite maize inbred lines (2002)

No decline of linkage disequilibrium within a few hundred base pairs was found in the elite maize germplasm. This finding, as well as the small number of haplotypes, relative to neutral expectation, is consistent with the effects of breeding-induced bottlenecks and selection on the elite germplasm pool. The genetic distance between haplotypes is large, indicative of an ancient gene pool and of possible interspecific hybridization events in maize ancestry.
LARYNGEAL SQUAMOUS CELL CARCINOMA WITH RENAL METASTASIS: A RARE CASE REPORT (2015)

Laryngeal squamous cell carcinoma tends to exhibit local spread with a low incidence of distal metastases. The majority of distant metastases are to the lungs and renal involvement is extremely rare. We present a rare case of metastatic renal tumour originating from Laryngeal squamous cell carcinoma. Fifty year old male diagnosed two years back as Laryngeal squamous cell carcinoma, underwent complete chemo radiation and was clinically free of disease for about two years, now presented with gross haematuria. Physical examination revealed left renal mass which was confirmed on CT scan as heterogeneously enhanced mass in upper part of kidney. Nephrectomy was done. On histopathological examination, well-differentiated squamous cell carcinoma of kidney was reported.
Peacock Hashing: Deterministic and Updatable Hashing for High Performance Networking (2008)

Hash tables are extensively used in networking to implement data-structures that associate a set of keys to a set of values, as they provide O(1), query, insert and delete operations. However, at moderate or high loads collisions are quite frequent which not only increases the access time, but also induces non- determinism in the performance. Due to this non-determinism, the performance of these hash tables degrades sharply in the multi-threaded network processor based environments, where a collection of threads perform the hashing operations in a loosely synchronized manner. In such systems, it is critical to keep the hash operations more deterministic. A recent series of papers have been proposed, which employs a compact on-chip memory to enable deterministic and fast hash queries. While effective, these schemes require substantial on- chip memory, roughly 10-bits for every entry in the hash table. This limits their general usability; specifically in the network processor context, where on-chip resources are scarce. In this paper, we propose a novel hash table construction called <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Peacock</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">hash</i> , which reduces the on-chip memory by more than 10-folds while keeping a high degree of determinism in performance. This significantly reduced on-chip memory not only makes Peacock hashing much more appealing for the general use but also makes it an attractive choice for the implementation of a hash hardware accelerator on a network processor.
Neurotoxic protein oligomers — what you see is not always what you get (2005)

An increasing body of evidence suggests that soluble assemblies of amyloid proteins are the predominant neurotoxic species in many amyloid-related diseases. Consequently, the focus of research on pathologic mechanisms underlying amyloidoses has shifted from amyloid fibrils to oligomers. Biophysical characterization of oligomers is difficult due to their metastable nature. The most popular experimental method for detection of oligomers has been SDS-PAGE. However, we provide experimental evidence that SDS-PAGE is not a reliable method for characterization of amyloid protein oligomers and discuss alternative approaches. In addition, we discuss how inconsistent nomenclature has obfuscated our understanding of the process and products of protein assembly. The goals of this paper are to identify pitfalls associated with the methods and language used to study protein oligomers and to provide alternatives, thereby facilitating successful elucidation of the mechanisms controlling amyloid protein oligomer assembly and toxicity.
Systemic Lupus Erythematosus: Emerging Concepts: Part 1: Renal, Neuropsychiatric, Cardiovascular, Pulmonary, and Hematologic Disease (1995)

Cytotoxic agents are superior to glucocorticoid therapy for the treatment of proliferative lupus nephritis, but the optimal duration and intensity of cytotoxic therapy remain undefined. Definitive studies of the treatment of autoimmune thrombocytopenia and acute pulmonary disease and of the diagnosis and treatment of neuropsychiatric disease are not available.
Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway (1995)

We have previously reported that serum amyloid A (SAA) induces adhesion and chemotaxis of human monocytes and polymorphonuclear neutrophils, in vitro as well as in vivo. Since the mechanism of SAA signaling is unknown, we have investigated the possibility that SAA, like other chemoattractants such as the chemotactic peptide FMLP and chemokines, might induce migration of monocytes by G protein activation. We report here that preincubation of monocytes with pertussis toxin (PTx) inhibited SAA chemotaxis, while incubation with cholera toxin (CTx) did not. Staurosporine and H-7, both inhibitors of protein kinase C (PKC), significantly decreased rSAA-induced chemotaxis of monocytes, suggesting that PKC may be involved in the rSAA signaling pathway. Moreover, rSAA, at concentrations that were effective in chemoattracting monocytes, resulted in transient elevation of cytoplasmic calcium concentration ([Ca2+]i), and incubation of cells with PTx markedly inhibited the mobilization of Ca2+ in response to rSAA. This suggests that both chemotaxis and the rise in [Ca2+]i, are mediated by G proteins of the Gi class. The increase in [Ca2+]i, induced in monocytes by rSAA, was comparable to that elicited by FMLP, and was severalfold greater than that induced by optimal concentrations of chemokine beta-family members such as RANTES, MCAF/MCP-1, and MIP-1 alpha. The chemoattractants FMLP, RANTES, MIP-1 alpha, and MCAF/MCP-1, all failed to desensitize rSAA-induced Ca2+ influx and chemotaxis in monocytes. This suggests that SAA uses a distinct receptor that is coupled to PTx-sensitive G proteins.
Autoprotolysis in aqueous organic solvent mixtures (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutoprotolysis in aqueous organic solvent mixturesMarti. Roses, Clara. Rafols, and Elisabeth. BoschCite this: Anal. Chem. 1993, 65, 17, 2294–2299Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ac00065a021https://doi.org/10.1021/ac00065a021research-articleACS PublicationsRequest reuse permissionsArticle Views605Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pre-mRNA processing factors meet the DNA damage response (2013)

It is well-known that DNA-damaging agents induce genome instability, but only recently have we begun to appreciate that chromosomes are fragile per se and frequently subject to DNA breakage. DNA replication further magnifies such fragility, because it leads to accumulation of single-stranded DNA. Recent findings suggest that chromosome fragility is similarly increased during transcription. Transcripts produced by RNA polymerase II (RNAPII) are subject to multiple processing steps, including maturation of 5' and 3' ends and splicing, followed by transport to the cytoplasm. RNA maturation starts on nascent transcripts and is mediated by a number of diverse proteins and ribonucleoprotein particles some of which are recruited cotranscriptionally through interactions with the carboxy-terminal domain of RNAPII. This coupling is thought to maximize efficiency of pre-mRNA maturation and directly impacts the choice of alternative splice sites. Mounting evidence suggests that lack of coordination among different RNA maturation steps, by perturbing the interaction of nascent transcripts with the DNA template, has deleterious effects on genome stability. Thus, in the absence of proper surveillance mechanisms, transcription could be a major source of DNA damage in cancer. Recent high-throughput screenings in human cells and budding yeast have identified several factors implicated in RNA metabolism that are targets of DNA damage checkpoint kinases: ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3 related) (Tel1 and Mec1 in budding yeast, respectively). Moreover, inactivation of various RNA processing factors induces accumulation of γH2AX foci, an early sign of DNA damage. Thus, a complex network is emerging that links DNA repair and RNA metabolism. In this review we provide a comprehensive overview of the role played by pre-mRNA processing factors in the cell response to DNA damage and in the maintenance of genome stability.
STUDIES ON THE PATHOGENESIS OF FEVER (1970)

Suppression of the pyrogen-producing capacity of exudate granulocytes results from incubation of the cells in plasma, serum, or Ringer's solution. When transferred in this state and incubated in isotonic NaCl, the cells release much less pyrogen than untreated exudate cells. The suppressive effect is reversible and appears to involve the cellular uptake of calcium ions. In contrast, regeneration of pyrogen-producing capacity in depleted exudate cells occurs only when the cells are incubated in serum. The process resembles activation and requires the cellular synthesis of protein.
The Effect of Intravenous Ferric Carboxymaltose on Red Cell Distribution Width: A Subanalysis of the FAIR-HF Study (2013)

Iron deficiency in CHF is associated with high RDW, even after adjustment for the presence of anaemia. Treatment with i.v. FCM in iron-deficient CHF patients decreases RDW.
The association of body mass index with the risk of type 2 diabetes: a case–control study nested in an electronic health records system in the United States (2014)

BMI is strongly and independently associated with the risk of being diagnosed with T2D. The incremental association of BMI category on the risk of T2D is stronger for people with a higher BMI relative to people with a lower BMI.
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. (1998)

In this study we sought to learn about when and how amyloid beta-protein (A beta) accumulates in the cortex of normal individuals and about the difference in the A beta accumulation between normal aged and Alzheimer's disease (AD) brains. From consecutive autopsy cases and AD cases, hippocampus CA1 and occipitotemporal cortex T4 were sampled for A beta quantitation by the well characterized two-site enzyme immunoassays (EIAs). There was a strong tendency toward A beta 42 accumulation between the ages of 50 and 70 years in T4 and a little later in CA1. The A beta 42 levels were consistently higher in T4 than those in CA1 in any given case. The levels of A beta 42 in AD brains were significantly higher than those in control brains, and the extent of A beta 42 amino-terminal modification was also much greater in AD brains than that in control brains. Even in cases in which no senile plaques were immunocytochemically detected, EIAs clearly showed that significant amounts of A beta 42 already had accumulated. In contrast to A beta 42, A beta 40 showed no apparent age-dependent accumulation, and its high levels were found to be associated with AD.
Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors (2000)

Effective gene therapy depends on the efficient transfer of therapeutic genes and their protein products to target cells. Lentiviral vectors appear promising for virus-mediated gene delivery and long-term expression in nondividing cells. The herpes simplex virus type 1 tegument protein VP22 has recently been shown to mediate intercellular transport of proteins, raising the possibility that it may be helpful in a setting where the global delivery of therapeutic proteins is desired. To investigate the effectiveness of lentiviral vectors to deliver genes encoding proteins fused to VP22, and to test whether the system is sufficiently potent to allow protein delivery from transduced cells in vitro and in vivo, fusion constructs of VP22 and the enhanced green fluorescent protein (EGFP) were prepared and delivered into target cells by using HIV-1-based lentiviral vectors. To follow the spread of VP22-EGFP to other cells, transduced COS-7 cells were coplated with a number of different cell types, including brain choroid plexus cells, human endothelial cells, H9 cells, and HeLa cells. We found that VP22-EGFP fusion proteins were transported from transduced cells to recipient cells and that such fusion proteins accumulated in the nucleus and in the cytoplasm of such cells. To determine the ability to deliver fusion proteins in vivo, we injected transduced H9 cells as well as the viral vector directly into the brain of mice. We present evidence that VP22-EGFP fusion proteins were transported effectively from lentivirus transduced cells in vivo. We also show that the VP22-EGFP fusion protein encoded by the lentivirus is transported between cells. Our data indicate that such fusion proteins are present in the nucleus and in the cytoplasm of neighboring cells. Therefore, lentiviral vectors may provide a potent biological system for delivering genes encoding therapeutic proteins fused to VP22.
Preparation of a High-Tc Y-Ba-Cu-O Superconductor Using Colloidal Methods (1987)

New synthetic procedures of a Y-Ba-Cu-O superconductor obtained through homogeneous colloidal precursors are described. These are formed by hydrolysis (olation) and in situ oxidation reaction (oxolation) of a mixture of metal ions in an aqueous solution. The resulting specimens exhibit a high- T c superconducting state after calcination. Resistance drops at around 95 K and completely vanishes at 75 K. These procedures will provide a conventional process for producing superconductive thin films and wires.
Pathogenesis of swine influenza virus (Thai isolates) in weanling pigs: an experimental trial (2009)

The results demonstrated that both SIV subtypes were able to induce flu-like symptoms and lung lesions in weanling pigs. However the severity of the diseases with regards to lung lesions both gross and microscopic lesions was greater in the H1N1-infected pigs. Based on phylogenetic analysis, haemagglutinin gene of subtype H1N1 from Thailand clustered with the classical H1 SIV sequences and neuraminidase gene clustered with virus of avian origin, whereas, both genes of H3N2 subtype clustered with H3N2 human-like SIV from the 1970s.
A New Design Method for the Passive Damped LCL and LLCL Filter-Based Single-Phase Grid-Tied Inverter (2012)

A higher order passive power filter (LLCL filter) for the grid-tied inverter is becoming attractive for industrial applications due to the possibility to reduce the cost of the copper and the magnetic material. However, similar to the conventional LCL filter, the grid-tied inverter is facing control challenges. An active or a passive damping measure can be adopted to suppress the possible resonances between the grid and the inverter. For an application with a stiff grid, a passive damping method is often preferred for its simpleness and low cost. This paper introduces a new passive damping scheme with low power loss for the LLCL filter. Also, a simple engineering design criterion is proposed to find the optimized damping resistor value, which is both effective for the LCL filter and the LLCL filter. The control analysis and the power loss comparison for different filter cases are given. All these are verified through the experiments on a 2-kW single-phase grid-tied inverter prototype using proportional resonant controllers. It is concluded that, compared with the LCL filter, the proposed passive damped LLCL filter can not only save the total filter inductance and reduce the volume of the filter but also reduce the damping power losses for a stiff grid application.
mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer (2011)

Ionizing radiation (IR) is used frequently in the management of multiple tumor types, including both organ-confined and locally advanced prostate cancer (PCa). Enhancing tumor radiosensitivity could both reduce the amount of radiation required for definitive treatment and improve clinical outcome. Androgen suppression therapy improves clinical outcomes when combined with radiation therapy but is associated with significant acute and chronic toxicities; hence, there is a clear need for alternative means to increase the therapeutic window of radiotherapy. Herein, it is demonstrated that the mammalian target of rapamycin (mTOR) inhibitors rapamycin (sirolimus) and temsirolimus limit both hormone therapy (HT)-sensitive and castration-resistant PCa (CRPC) cell proliferation as single agents and have a profound radiosensitization effect when used in combination with IR. Importantly, the observed radiosensitization was influenced by the treatment schedule, in which adjuvant administration of mTOR inhibitors was most effective in limiting PCa cell population doubling. This schedule-dependent influence on in vitro treatment outcome was determined to be the result of relative effects on the cell cycle kinetics. Finally, adjuvant administration of either mTOR inhibitor tested after IR significantly decreased clonogenic cell survival of both HT-sensitive and CRPC cells compared with IR alone. Taken together, these data demonstrate that inhibition of mTOR confers a radiosensitization phenotype that is dependent on relative cell cycle kinetics and provide a foundation for clinical assessment.
Nanoscintillator Conjugates as Photodynamic Therapy-Based Radiosensitizers: Calculation of Required Physical Parameters (2009)

The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the application of photodynamic therapy to deeply seated tumors. In this study, we calculated the physical parameters required for these nanoparticle conjugates to deliver cytotoxic levels of singlet oxygen at therapeutic radiation doses, drawing on the published literature from several disparate fields. Although uncertainties remain, it appears that the light yield of the nanoscintillators, the efficiency of energy transfer to the photosensitizers, and the cellular uptake of the nanoparticles all need to be fairly well optimized to observe a cytotoxic effect. Even so, the efficacy of the combination therapy will likely be restricted to X-ray energies below 300 keV, which limits the application to brachytherapy.
Ethyl N-(2-pyridyl)carbamate (2005)

The title compound, C8H10N2O2, is nearly planar. The crystal packing is stabilized by N—H⋯N hydrogen bonds.
Structure-Guided Peptidomimetic Design Leads to Nanomolar β-Hairpin Inhibitors of the Tat−TAR Interaction of Bovine Immunodeficiency Virus, (2006)

The Tat protein of immunodeficiency viruses is the main activator of viral gene expression. By binding specifically to its cognate site, the transactivator response element (TAR), Tat mediates a strong induction of the production of all viral transcripts. In seeking a new chemical solution to inhibiting viral protein-RNA interactions, we recently identified inhibitors of the viral Tat protein from the bovine immunodeficiency virus (BIV) using conformationally constrained beta-hairpin peptidomimetics. We identified a micromolar ligand, called BIV2, and the structure of its complex with BIV TAR was determined by NMR. In this work, we demonstrate that this chemistry can rapidly yield highly potent and selective ligands. On the basis of the structure, we synthesized and assayed libraries of mutant peptidomimetics. Remarkably, we were able in just a few rounds of design and synthesis to discover nanomolar inhibitors of the Tat-TAR interaction in BIV that selectively bind the BIV TAR RNA compared to RNA structures as closely related as the HIV-1 TAR or RRE elements. The molecular recognition principles developed in this study have been exploited in discovering related peptidomimetic inhibitors of the Tat-TAR interaction in HIV-1.