gebhart/patrepeval huggingface dataset:
Serial assessment of left ventricular diastolic function after Fontan procedure (2000)

OBJECTIVE To assess longitudinal changes in systemic ventricular diastolic function late after the Fontan procedure. DESIGN AND PATIENTS Prospective study of 13 patients at 2.8 (2.0) years (early) and again at 11.4 (2.0) years (late) after the Fontan procedure by Doppler echocardiography with simultaneous ECG, phonocardiogram, and respirometer. SETTING Tertiary paediatric cardiac centre. RESULTS The isovolumic relaxation time (IVRT) was significantly longer, and E wave deceleration time, E and A wave velocities, and E:A velocity ratio were reduced compared to normal both early and late after the procedure. The mean (SD) z score of IVRT decreased significantly from +2.50 (1.00) to +1.24 (0.80) (p = 0.002), and the z score of the E wave deceleration time decreased from −1.69 (1.31) to −2.40 (1.47) (p = 0.03) during follow up. The A wave deceleration time also tended to decrease (early 80 (12) ms v late 73 (11) ms, p = 0.13) with increased follow up. There were no changes of the E and A wave velocities and E:A velocity ratio. The E wave velocity was inversely related to IVRT both early ( r = −0.82, p = 0.001) and late ( r = −0.59, p = 0.034) after the operation. The prevalence of diastolic flow during isovolumic relaxation decreased from 85% (11/13) to 38% (5/13) (p = 0.04), while that of mid diastolic flow increased from 23% (3/13) to 77% (10/13) (p = 0.02) between the two assessments. CONCLUSIONS Left ventricular diastolic function remains highly abnormal late after the Fontan procedure. The longitudinal changes demonstrated on follow up are compatible with reduction of left ventricular compliance in addition to persisting abnormalities of relaxation.
Cleaning of Silicon Surfaces by NF3 Added Hydrogen and Water Vapor Plasma Downstream Treatment (1995)

Native oxide was removed from silicon surfaces by NF3-added hydrogen and water-vapor plasma downstream treatment. It took 45 s to remove native oxide from a 6-inch silicon wafer. Fourier transform infrared attenuated total reflection (FT-IR ATR) measurement revealed that the surface roughness after the downstream treatment was the same as that after wet cleaning with 2% HF solution. A silicon epitaxial layer was grown on the surface cleaned by the downstream treatment. Although process temperature was as low as 100°C, the present downstream treatment induced the same effect as in situ hydrogen annealing.
Coherent emission from ultrathin-walled spiral InGaAs/GaAs quantum dot microtubes (2009)

We report on the achievement of strong coherent emission from GaAs-based single-walled spiral microtubes, wherein photons are localized in an ultrathin (approximately lambda/25) region embedded with self-organized InGaAs quantum dots. The emission spectra measured at 300 K are characterized by a regular sequence of sharp optical modes with a maximum Q factor of approximately 2500 and separation of approximately 7 meV. The three-dimensional confinement of photons is made possible by the epitaxially smooth tube surface as well as an engineered surface geometry, achieved using a single photolithography step. The experimental results are analyzed using an equivalent planar dielectric waveguide model.
Halo sugar nucleosides. IV. Synthesis of some 4',5'-unsaturated pyrimidine nucleosides (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHalo sugar nucleosides. IV. Synthesis of some 4',5'-unsaturated pyrimidine nucleosidesJulien P. H. Verheyden and John G. MoffattCite this: J. Org. Chem. 1974, 39, 24, 3573–3579Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://doi.org/10.1021/jo00938a027RIGHTS & PERMISSIONSArticle Views355Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Stereoselective Preparationof Functionalized Unsaturated Lactones and Esters via FunctionalizedMagnesium Carbenoids (2003)

The reaction of β,β-dibromo or diiodo unsaturatedesters with i-PrMgCl (1 equivalent) indiethyl ether allows the generation of functionalized alkenylmagnesiumcarbenoids which react with retention of configuration with variouselectrophiles providing polyfunctionalized unsaturated esters andlactones. By using two equivalents of i-PrMgCl,a 1,2-migration with retention of configuration occurs in diethylether allowing a new synthesis of tetrasubstituted esters and lactones.
Enforced Expression of MCAM/MUC18 Increases In vitro Motility and Invasiveness and In vivo Metastasis of Two Mouse Melanoma K1735 Sublines in a Syngeneic Mouse Model (2008)

Human MCAM/MUC18 has been shown to increase metastasis of human melanoma cells in xenograft mouse systems. To be more relevant to understanding the progression of clinical melanoma and for designing better preclinical therapeutic trials, it is highly desirable to establish a syngeneic mouse model for studying the mechanisms of MCAM/MUC18-mediated tumorigenesis and metastasis of melanoma cells. To reach this goal, we transfected the mouse MCAM/MUC18 (moMCAM/MUC18) cDNA into two MCAM/MUC18-minus, low-metastatic mouse melanoma K1735 sublines, K1735-10 (tumor(-)/met(low)) and K1735-3 (tumor(+)/met(low)), and selected for G418-resistant clones, which expressed different levels of moMCAM/MUC18, and used for testing the effect of MCAM/MUC18 overexpression on their in vitro growth rate, motility, and invasiveness and in vivo subcutaneous tumor growth and pulmonary metastasis in syngeneic mice. Enforced expression of moMCAM/MUC18 did not significantly affect in vitro growth rate, but it increased the in vitro motility and invasiveness of clones derived from both sublines. Ectopic expression of moMCAM/MUC18 did not alter the nontumorigenicity of the K1735-10 clones per cells nor significantly affect the subcutaneous tumor growth of the K1735-3 clones per cells. The moMCAM/MUC18-expressing K1735-10 clones were able to establish only microscopic lung modules in 86% of the mice. In contrast, the moMCAM/MUC18-expressing K1735-3 clones could induce numerous large lung nodules (3-4 mm in diameter) in all the mice. We concluded that increased moMCAM/MUC18 expression in the two K1735 sublines minimally affected their tumorigenicity, but it augmented their in vitro motility and invasiveness and increased their pulmonary metastasis in the syngeneic C3H mice.
Photo-realistic 3D model reconstruction (2006)

Photo-realistic 3D modeling is a challenging problem and has been a research topic for many years. Quick generation of photo-realistic three-dimensional calibrated models using a hand-held device is highly desirable for applications ranging from forensic investigation, mining, to mobile robotics. In this paper, we present the instant Scene Modeler (iSM), a 3D imaging system that automatically creates 3D models using an off-the-shelf hand-held stereo camera. The user points the camera at a scene of interest and the system will create a photo-realistic 3D calibrated model automatically within minutes. Field tests in various environments have been carried out with promising results
Picosecond optical sampling of GaAs integrated circuits (1988)

Direct electrooptic sampling is a noncontact optical-probing technique for measuring with picosecond time resolution the voltage waveforms at internal nodes within GaAs integrated circuits. The factors contributing to system bandwidth, sensitivity, spatial resolution, and circuit perturbation are discussed, as are the circuit requirements for realistic testing of analog and digital devices. Measurements of high-speed GaAs integrated circuits are presented, including time-domain waveform and timing measurements of digital and analog circuits and frequency-domain transfer function measurements of microwave circuits and transmission structures.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mobile interactive region-of-interest video streaming with crowd-driven prefetching (2011)

Small screen sizes, limited bandwidth, and low computational power often prohibit streaming of high-resolution videos to mobile devices over a wireless network. Recent advances in interactive region-of-interest (IRoI) video streaming technology allow users to interactively control pan/tilt/zoom, while providing bit-rate and complexity savings. In this paper, we present a mobile IRoI video streaming system that delivers high-quality interactive video to smartphones and tablets with multi-touch screens. One of the challenges in IRoI video streaming is to enable low-latency interaction when a user switches between different RoIs. We propose a crowd-driven RoI prediction scheme to prefetch future selected regions. Different from previous approaches that extrapolate past user inputs or perform video semantic analysis, our proposed scheme exploits user viewing statistics collected at the server to make RoI predictions. Our experiments show that a crowd-driven prefetching scheme can substantially reduce average RoI switching delays compared to a system without prefetching.
Enhanced transmission due to nonplasmon resonances in one- and two-dimensional gratings (2004)

Enhanced transmission through subwavelength slit gratings and hole arrays is studied in view of its application in the far-infrared and microwave domains. Because for perfectly conducting gratings, plasmon resonances are not expected to produce an enhanced transmission, other kinds of resonance, such as Fabry-Perot, waveguide-mode, and cavity-mode resonances, are studied. The possibility of reaching 100% transmittivity for some particular wavelengths is established when two superimposed identical gratings are used while each of them transmits approximately 1% off resonance. A similar transmission is obtained with hole arrays. The study of the field map inside the groove region allows our establishing the nature of the resonance, that is involved. Comparison of the bandwidth with respect to the wavelength or incidence given by various kinds of resonance is presented.
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. (1993)

A central question in the endocytic process concerns the mechanism for sorting of recycling components (such as transferrin or low density lipoprotein receptors) from lysosomally directed components; membrane-associated molecules including receptors are generally directed towards the recycling pathway while the luminal content of sorting endosomes, consisting of the acid-released ligands, are lysosomally targeted. However, it is not known whether recycling membrane receptors follow bulk membrane flow or if these proteins are actively sorted from lysosomally directed material because of specific protein sequences and/or structural features. Using quantitative fluorescence microscopy we have determined the endocytic route and kinetics of traffic of the bulk carrier, membrane lipids, to address this issue directly. We show that N-[N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl]- sphingosylphosphorylcholine (C6-NBD-SM) in endocytosed as bulk membrane, and it transits the endocytic system kinetically and morphologically identically to fluorescently labeled transferrin in a CHO cell line. With indistinguishable kinetics, the two labeled markers sort from lysosomally destined molecules in peripherally located sorting endosomes, accumulate in a peri-centriolar recycling compartment, and finally exit the cell. Other fluorescently labeled lipids, C6-NBD-phosphatidylcholine and galactosylceramide also traverse the same pathway. The constitutive nature of sorting of bulk membrane towards the recycling pathway and the lysosomal direction of fluid phase implies a geometric basis of sorting.
Multi-physics design and performance of a surface- micromachined Ka-band cavity backed patch antenna (2007)

A rectangular coaxial line fed cavity backed patch antenna element for a Ka-band phased array at 36 GHz is presented in this paper. The antenna is fabricated by a sequential microfabrication surface micromachining process with ten structural layers. The patch is 2.8 mm long and 3.2 mm wide and has two slits for impedance matching and six holes for releasing the sacrificial photoresist. It is supported with the feeding probe and two metallic posts located in the plane with zero E-field. The electromagnetic-thermal-stress analysis and design are conducted with the finite element and finite integration codes. Individual antenna elements have impedance bandwidth of about 5.1% around 36 GHz, with simulated gain and radiation efficiency of about 6.8 dBi and 95%, respectively.
The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization (2016)

Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual consumption has become common among the mestizo populations of South America. Ayahuasca use amongst the indigenous people of the Amazon is a form of traditional medicine and cultural psychiatry. During the last two decades, the substance has become increasingly known among both scientists and laymen, and currently its use is spreading all over in the Western world. In the present paper we describe the chief characteristics of ayahuasca, discuss important questions raised about its use, and provide an overview of the scientific research supporting its potential therapeutic benefits. A growing number of studies indicate that the psychotherapeutic potential of ayahuasca is based mostly on the strong serotonergic effects, whereas the sigma-1 receptor (Sig-1R) agonist effect of its active ingredient dimethyltryptamine raises the possibility that the ethnomedical observations on the diversity of treated conditions can be scientifically verified. Moreover, in the right therapeutic or ritual setting with proper preparation and mindset of the user, followed by subsequent integration of the experience, ayahuasca has proven effective in the treatment of substance dependence. This article has two important take-home messages: (1) the therapeutic effects of ayahuasca are best understood from a bio-psycho-socio-spiritual model, and (2) on the biological level ayahuasca may act against chronic low grade inflammation and oxidative stress via the Sig-1R which can explain its widespread therapeutic indications.
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide (1994)

Incubation of rat skeletal muscle mitochondria with the nitric oxide generator, S-nitrosoglutathione (GSNO) reversibly inhibited oxygen utilisation with all substrates tested. The visible absorption spectra of the inhibited mitochondria showed that cytochromes c+c1, b and a+a3 were reduced, indicating a block at the distal end of the respiratory chain. Analysis of the respiratory chain enzyme activities in the presence of GSNO localised the site of inhibition of cytochrome c oxidase alone. These results indicate that nitric oxide is capable of rapidly and reversibly inhibiting the mitochondrial respiratory chain and may be implicated in the cytotoxic effects of nitric oxide in the CNS and other tissues.
Propranolol and Depression: Evidence from the Antihypertensive Trials (1990)

The relationship between propranolol and depression is a subject of controversy. Numerous case reports suggest that propranolol can cause depression, but two small prospective trials have failed to confirm this. The contemporary psychiatric literature is divided as to whether propranolol can cause depression. This study addresses this issue by re-analyzing side effect data from clinical trials of propranolol as an antihypertensive agent. A literature review was carried out and the data were analyzed using meta-analytic statistical techniques. Propranolol was found to cause depression as a side effect with a statistically greater frequency than the control medications used in these trials. As other side effects of propranolol include fatigue, diminished energy, decreased libido, anorexia and poor concentration, it is suggested that propranolol is a cause of organic mood disorder, depressed type.
Combined Blind Equalization and Automatic Modulation Classification for Cognitive Radios (2009)

Blind equalization and automatic modulation classification (AMC) have been of significant importance for cognitive radios when the receiver has no information about the channel or modulation type. Choosing an appropriate equalizer is difficult in the absence of channel information. In this paper, an AMC based on cyclostationary feature detection and a predictor-based recursive blind equalizer is used in conjunction. The probability of classification of the AMC is used as a metric and fed back to update the blind equalizer order. The equalizer and the AMC enhance the performance of each other. Computer simulations are given to illustrate the concept and yield promising results.
Bayesian Density Estimation and Inference Using Mixtures (1995)

Abstract We describe and illustrate Bayesian inference in models for density estimation using mixtures of Dirichlet processes. These models provide natural settings for density estimation and are exemplified by special cases where data are modeled as a sample from mixtures of normal distributions. Efficient simulation methods are used to approximate various prior, posterior, and predictive distributions. This allows for direct inference on a variety of practical issues, including problems of local versus global smoothing, uncertainty about density estimates, assessment of modality, and the inference on the numbers of components. Also, convergence results are established for a general class of normal mixture models.
The Potential Role of Plasma Gelsolin in Dialysis-Related Protein-Energy Wasting (2010)

Protein-energy wasting (PEW) is increasingly recognized to be a prevalent and significant contributor to the clinical deterioration of patients with chronic kidney disease (CKD). While factors reflecting various aspects of PEW correlate with outcomes in CKD, the mechanism linking PEW and CKD outcomes is not completely understood. Plasma gelsolin (pGSN) is a highly abundant circulating protein that is depleted by inflammatory mediators and mainly produced by muscles. Recent data documenting the prognostic ability of low pGSN levels in hemodialysis patients suggests that circulating pGSN levels incorporate the degree of systemic inflammation and muscle wasting. Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in CKD patients.
Tissue plasminogen activator induced by dengue virus infection of human endothelial cells (2003)

Dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS) are severe complications of dengue virus (DV) infection. However, the pathogenesis of hemorrhage induced by dengue virus infection is poorly understood. Since endothelial cells play a pivotal role in the regulation of hemostasis, we studied the effect of DV infection on the production of tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI-1) in vitro using both primary isolated endothelial cells, human umbilical cord veins cells, and a human microvascular endothelial cell line. DV infection significantly induced the secretion of tPA but not PAI-1 of human endothelial cells. In addition, tPA mRNA of endothelial cells was induced by DV as demonstrated by RT-PCR. Antibody against IL-6 but not control antibody inhibited DV-induced tPA production of endothelial cells. Furthermore, a good correlation between sera levels of IL-6 and tPA was found in DHF but not DF patients. These results suggest that IL-6 can regulate DV-induced tPA production of endothelial cells, which may play important roles in the pathogenic development of DHF/DSS.
How Common Is Resistance to Treatment in Recurrent, Nonpsychotic Geriatric Depression? (1998)

The study suggests a relatively low rate of resistance to treatment among depressed geriatric patients referred to a university tertiary care setting.
Ground Penetrating Radar Measurements in a Controlled Vadose Zone: Influence of the Water Content (2004)

Ground penetrating radar (GPR) is a nondestructive method, which, as with other geophysical methods, has been successfully used to estimate the water content or hydraulic properties of soils. We performed GPR measurements to calibrate and compare water content estimates with actual water contents in a sand box. A vadose zone was simulated by injecting water in a sand box. We obtained four GPR data sets: for dry sand, for sand with water tables at 72- and 48-cm depths, and for sand after drainage. Using the reflections (or diffractions) from the bottom of the sand box (or objects buried in the sand), mean relative dielectric permittivities were determined at several depths in the sand box. These relative dielectric permittivities were used to calculate “real” mean relative dielectric permittivities of a sand box made up of three layers (dry sand, unsaturated sand, and fully saturated sand), knowing that a layer can be subdivided into more layers depending on the depth of the reflections (or diffractions) recorded. We used three relationships between relative dielectric permittivity and the water content to estimate the mean water content for each layer. From these water contents and the known volume of sand considered, we estimated the amount of water in the sand box for each water table. Subtracting the volume obtained for dry sand from the volume obtained for the different water tables gave estimates of the variations in water quantities in the sand box; these were compared with the quantities injected in the sand box. Despite uncertainties in the determination of the mean relative dielectric permittivities, the calculated variations in water quantities were very similar to those injected in the sand box.
Chronology and evolution of the Middle Proterozoic Albany‐Fraser Orogen, Western Australia (1995)

Geochemical and Sm‐Nd isotopic data, and 19 ion‐microprobe U‐Pb zircon dates are reported for gneiss and granite from the eastern part of the Albany‐Fraser Orogen. The orogen is dominated by granitic rocks derived from sources containing both Late Archaean and mantle‐derived components. Four major plutonic episodes have been identified at ca 2630 Ma, 1700–1600 Ma, ca 1300 Ma and ca 1160 Ma. Orthogneiss, largely derived from ca 2630 Ma and 1700–1600 Ma granitic precursors, forms a belt along the southeastern margin of the Yilgarn Craton. These rocks, together with gabbro of the Fraser Complex, were intruded by granitic magmas and metamorphosed in the granulite facies at ca 1300 Ma. They were then rapidly uplifted and transported westward along low‐angle thrust faults over the southeastern margin of the Yilgarn Craton. Between ca 1190 and 1130 Ma, granitic magmas were intruded throughout the eastern part of the orogen. These new data are integrated into a review of the geological evolution of the Albany‐Fraser Orogen and adjacent margin of eastern Antarctica, and possibly related rocks in the Musgrave Complex and Gawler Craton.