gebhart/patrepeval huggingface dataset:
On the applications of multimedia processing to communications (1998)

The challenge of multimedia processing is to provide services that seamlessly integrate text, sound, image, and video information and to do it in a way that preserves the ease of use and interactivity of conventional plain old telephone service (POTS) telephony. To achieve this goal, there are a number of technological problems that must be considered, including: compression and coding of multimedia signals, including algorithmic issues, standards issues, and transmission issues; synthesis and recognition of multimedia signals, including speech, images, handwriting, and text; organization, storage, and retrieval of multimedia signals, including the appropriate method and speed of delivery, resolution, and quality of service; access methods to the multimedia signal, including spoken natural language interfaces, agent interfaces, and media conversion tools; searching by text, speech, and image queries; browsing by accessing the text, by voice, or by indexed images. In each of these areas, a great deal of progress has been made in the past few years, driven in part by the relentless growth in multimedia personal computers and in part by the promise of broad-band access from the home and from wireless connections. Standards have also played a key role in driving new multimedia services, both on the POTS network and on the Internet. It is the purpose of this paper to review the status of the technology in each of the areas listed above and to illustrate current capabilities by describing several multimedia applications that have been implemented at AT&T Labs over the past several years.
Patient-to-Patient Transmission of Hepatitis C Virus during Colonoscopy (1997)

Invasive diagnostic or therapeutic procedures may be a route for the transmission of the hepatitis C virus (HCV).1–5 In a study of patients in a gastrointestinal-disease unit, endoscopic biopsies were found to be an independent risk factor for HCV infection.6 We report the transmission of HCV during colonoscopy from a person known to have HCV infection to two other patients. The patient-to-patient transmission was ascertained by sequencing the nucleotides in the various HCV isolates. Case Report A 55-year-old man (Patient 1) and his 54-year-old wife (Patient 2) were referred in October 1995. In June 1995, both had had hepatitis-like . . .
Propagation-invariant wave fields with finite energy (2000)

Propagation invariance is extended in the paraxial regime, leading to a generalized self-imaging effect. These wave fields are characterized by a finite number of transverse self-images that appear, in general, at different orientations and scales. They possess finite energy and thus can be accurately generated. Necessary and sufficient conditions are derived, and they are appropriately represented in the Gauss-Laguerre modal plane. Relations with the following phenomena are investigated: classical self-imaging, rotating beams, eigen-Fourier functions, and the recently introduced generalized propagation-invariant wave fields. In the paraxial regime they are all included within the generalized self-imaging effect that is presented. In this context we show an important relation between paraxial Bessel beams and Gauss-Laguerre beams.
Forecasting the Future of Cardiovascular Disease in the United States (2011)

These findings indicate CVD prevalence and costs are projected to increase substantially. Effective prevention strategies are needed if we are to limit the growing burden of CVD.
Optical coherent imaging of volume scattering media with near infrared tunable laser (2002)

The detection and imaging of highly scattering objects in scattering media can play an important part in assessing melanoma in human skin. The technique that is presented in this paper is based on frequency modulated continuous waves (FMCW) but uses a coherent near infrared tunable semiconductor laser. The performance of our imaging system is demonstrated on 2-D images taken from solid scattering material with known optical properties and several embedded objects. A reflecting and scattering rod can be seen up to 3 mm depth with a spatial resolution of 800 /spl mu/m.
Desensitization of Metabotropic Glutamate Receptors in Neuronal Cultures (1991)

Preexposure of cultured cerebellar neurons to glutamate reduced the stimulation of polyphosphoinositide (PPI) hydrolysis induced by subsequent addition of glutamate without affecting the response to the muscarinic receptor agonist carbamylcholine. Desensitization of glutamate-stimulated PPI hydrolysis developed rapidly and persisted up to 48 h after removal of glutamate from the incubation medium. Stimulation of PPI hydrolysis by quisqualate was abolished in cultures pretreated with quisqualate or glutamate, but not with N-methyl-D-aspartate (NMDA). In contrast, pretreatment with NMDA reduced the stimulation of PPI hydrolysis induced by a subsequent addition of NMDA, leaving the action of quisqualate intact. The lack of cross-desensitization between NMDA and quisqualate supports the existence of two distinct subtypes of glutamate receptors coupled to PPI hydrolysis. Desensitization induced by a 30-min (but not by a 6-h) exposure to glutamate was attenuated or prevented by putative protein kinase C inhibitors, including mono- and trisialogangliosides, sphingosine, and polymyxin B, but not by inhibitors of arachidonic acid metabolism, nor by the nonselective calpain inhibitor leupeptin, nor by the lectin concanavalin A. These results suggest that desensitization of metabotropic glutamate receptors involves, at least in its rapid component, activation of protein kinase C.
Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver. (1987)

A rat liver cDNA library enriched for glucokinase sequences was constructed using the phage expression vector lambda gt11 and screened with an antiserum to glucokinase. A positive phage clone termed lambda-GK223 was isolated by several rounds of plaque purification. When introduced in the high frequency lysogenization strain Y1089, the phage was shown to encode a fusion protein containing epitopes specific to rat liver glucokinase. The 1800-base pair cDNA insert of lambda-GK223 was subcloned in a pUC plasmid, and a resulting recombinant termed pUC-GK1 was used for hybrid selection of mRNA. The selected mRNA directed the synthesis in a cell-free translation system of a protein identified as glucokinase by electrophoresis and immunoprecipitation. The cloned cDNA was then used as a probe to measure the amount of glucokinase mRNA in rat liver during postnatal development. Glucokinase mRNA, 2.4 kilobases in length, was first detectable at day 14 after birth and increased 40-fold in amount from this age to day 31, in parallel with the emergence of glucokinase enzyme activity. In the adult rat, glucokinase mRNA was low during fasting and increased more than 50-fold above the fasting level within 6 h of an oral glucose load. However, maximal accumulation of glucokinase mRNA was short-lived and the mRNA level returned toward basal values by 18 h of refeeding. These data point to rapid and massive effects on the expression of the glucokinase gene at the transcriptional or post-transcriptional levels during ontogenic development and dietary changes in the adult animal.
Temporal Outlier Detection in Vehicle Traffic Data (2009)

Outlier detection in vehicle traffic data is a practical problem that has gained traction lately due to an increasing capability to track moving vehicles in city roads. In contrast to other applications, this particular domain includes a very dynamic dimension: time. Many existing algorithms have studied the problem of outlier detection at a single instant in time. This study proposes a method for detecting temporal outliers with an emphasis on historical similarity trends between data points. Outliers are calculated from drastic changes in the trends. Experiments with real world traffic data show that this approach is effective and efficient.
Synthesis of Large Arrays of Well-Aligned Carbon Nanotubes on Glass (1998)

Free-standing aligned carbon nanotubes have previously been grown above 700 degreesC on mesoporous silica embedded with iron nanoparticles. Here, carbon nanotubes aligned over areas up to several square centimeters were grown on nickel-coated glass below 666 degreesC by plasma-enhanced hot filament chemical vapor deposition. Acetylene gas was used as the carbon source and ammonia gas was used as a catalyst and dilution gas. Nanotubes with controllable diameters from 20 to 400 nanometers and lengths from 0. 1 to 50 micrometers were obtained. Using this method, large panels of aligned carbon nanotubes can be made under conditions that are suitable for device fabrication.
Decrease in Red Blood Cell Deformability Caused by Hypothermia, Hemodilution, and Mechanical Stress (1999)

During extracorporeal circulation in cardiopulmonary bypass (CPB) surgery, blood is exposed to anomalous mechanical and environmental factors, such as high shear stress, turbulence, decreased oncotic pressure caused by dilution of plasma, and moderate and especially deep hypothermia widely applied during CPB in infants. These factors cause damage to the red blood cells (RBCs), which is manifest by immediate and delayed hemolysis and by changes in the mechanical properties of RBCs. These changes include, in particular, decrease in RBC deformability impeding the passage of RBCs through the microvessels and may contribute to the complications associated with CPB surgery. We investigated in vitro the independent and combined effects of hypothermia, plasma dilution, and mechanical stress on deformability of bovine RBCs. Our studies showed each of these factors to cause a significant decrease in the deformability of RBCs, especially acting synergistically. The impairment of RBC deformability caused by hypothermia was found to be more pronounced for RBCs suspended in phosphate buffered saline (PBS) than for RBCs suspended in plasma. The decrease in RBC deformability caused by mechanical stress was significantly exacerbated by dilution of plasma with PBS. In summary, results of our in vitro study strongly point to a possible detrimental consequence of conventional CPB arising from increased RBC rigidity, which may lead to impaired microcirculation and tissue oxygen supply.
Approximate Design and Costing Methods for Heat Exchangers (2006)

Abstract Methodologies for the rapid sizing and costing of heat exchangers have been developed under the aegis of ESDU International plc, London. This paper is a summary of a group of design guides (referred to as “data items”) that cover a wide range of heat exchanger configurations. These data items are aimed at providing rapid selection, sizing, and costing at the process design stage. For two-stream exchangers, the C value method has been adopted in which the costs are expressed per unit (Q/ΔT m ), where [Qdot] is the heat load and ΔT m the mean temperature difference. The development and applications of this method are reviewed, with an emphasis on comparisons between various types of exchanger. The nature of variations from the standard cases considered are also discussed. Though the C value method can be applied to two-stream plate-fin exchangers, such exchangers often operate with multiple streams. Approximate calculations for the design of such multistream exchangers can be made using the concept of the volumetric heat transfer coefficient. This methodology can be combined with standard curves of the cost per unit volume as a function of volume to obtain an approximate costing of such exchangers. ACKNOWLEDGMENTS The authors would like to gratefully acknowledge the assistance of Heat Transfer Steering Group of ESDU in advising on the work described in this present article. They are also extremely grateful for the assistance of various working parties (drawn mainly from industry) who advised on the work on the specific heat exchanger types.
Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma (2017)

features of allergic asthma were regulated in part by Mt-CaMKII-mediated, Mt-ROS-induced activation of NF-B and the NLRP3 inflammasome. Taken together, our findings suggest that airway epithelial cellderived Mt-CaMKII increases Mt-ROS that promotes induction of core features of allergic asthma. These data implicate Mt-CaMKII in multiple processes in the development of asthma. Mitochondrial-localized CaMKII inhibition may provide a new potential candidate target for future asthma therapies.
Geomechanics field characterization of Woodford Shale and Barnett Shale with advanced logging tools and nano-indentation on drill cuttings (2010)

The Woodford Shale and Barnett Shale have emerged as prolific gas plays in the US midcontinent. However, the intrinsically low permeability of these gas shales hinders profitable pro-duction unless horizontal well drilling and multistage hydraulic fracturing are employed. The success of these operations depends on accurate de-terminations of the anisotropic elastic and poroelastic properties of these shale formations.
Experimental Analysis of the Quadriceps Muscle Force and Patello-Femoral Joint Reaction Force for Various Activities (1972)

(1972). Experimental Analysis of the Quadriceps Muscle Force and Patello-Femoral Joint Reaction Force for Various Activities. Acta Orthopaedica Scandinavica: Vol. 43, No. 2, pp. 126-137.
An investigation into the mechanism of protection by local passive immunization with monoclonal antibodies against Streptococcus mutans (1990)

Local oral passive immunization with Streptococcus mutans-specific monoclonal antibody (MAb) (Guy's 13) prevented recolonization by indigenous S. mutans in human volunteers who had first been treated with a conventional antibacterial agent (chlorhexidine). The F(ab')2 fragment of the MAb was as protective as the intact immunoglobulin G, but the Fab fragment of the molecule failed to prevent recolonization of S. mutans. In subjects receiving the MAb Fab fragment, S. mutans levels in dental plaque and saliva reappeared at a similar rate to that found in sham-immunized subjects who received either saline or a nonprotective MAb. In vitro, MAb had no bacteriostatic or bacteriocidal effect on S. mutans. However, S. mutans grown in the presence of either intact immunoglobulin G MAb or the F(ab')2 fragment formed very long chains, which resulted in clumping of the cells. S. mutans grown with either saline or the MAb Fab fragment formed significantly shorter chains, more characteristic of streptococcal growth in liquid media. The results suggest that the two binding sites of the MAb molecule may be an essential feature for preventing streptococcal colonization but that the ability to bind to phagocytes and activate complement which resides in the Fc fragment is not essential. Protection against colonization by S. mutans lasting up to 2 years was observed in immunized subjects, although MAb was applied over a period of only 3 weeks. Furthermore, functional MAb was detected up to 3 days following application of MAb to the teeth. The long-term protection could not be accounted for by a persistence of MAb on the tooth surface, and we have suggested that it may be due to a shift in the balance of the oral flora which discouraged recolonization by S. mutans. However, examination of the proportions of Streptococcus sanguis and veillonella species in the recolonization experiments failed to reveal a significant change in the proportions of either organism, which returned to approximately the preexperimental levels in both the immunized and control groups. These findings confirm the in vivo functional specificity of the MAb to S. mutans but are not consistent with the suggestion that S. sanguis or veillonella take over the niche vacated by S. mutans, unless the shift in the proportion of these organisms cannot be detected by the method used.
Dynamic clustered distribution of hemagglutinin resolved at 40 nm in living cell membranes discriminates between raft theories (2007)

Organization in biological membranes spans many orders of magnitude in length scale, but limited resolution in far-field light microscopy has impeded distinction between numerous biomembrane models. One canonical example of a heterogeneously distributed membrane protein is hemagglutinin (HA) from influenza virus, which is associated with controversial cholesterol-rich lipid rafts. Using fluorescence photoactivation localization microscopy, we are able to image distributions of tens of thousands of HA molecules with subdiffraction resolution ( approximately 40 nm) in live and fixed fibroblasts. HA molecules form irregular clusters on length scales from approximately 40 nm up to many micrometers, consistent with results from electron microscopy. In live cells, the dynamics of HA molecules within clusters is observed and quantified to determine an effective diffusion coefficient. The results are interpreted in terms of several established models of biological membranes.
Development of a slab waveguide spatial heterodyne spectrometer for remote sensing (2010)

We present development of a compact, robust, waveguide Fourier-transform microspectrometer for high-resolution and high-throughput spectroscopy in space-based applications. The prototype device is being developed to monitor water vapor in the atmosphere from a micro-satellite platform. The instrument is based on a unique slab waveguide spatial heterodyne spectrometer (SHS) chip fabricated at the National Research Council Canada in silicon-on-insulator (SOI) technology.
Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases (2017)

Our study demonstrates that linked read sequencing is useful in characterizing oncogenic rearrangements in cancer metastasis.
ChemInform Abstract: A Novel Concept for the Synthesis of an Improved LiFePO4 Lithium Battery Cathode. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations (2005)

Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D cells in suspension cultures. However, in contrast to Flt3-ITD and similar to wild-type Flt3 (Flt3-WT), Flt3-TKD cannot support colony formation in semisolid media. Also, in contrast to Flt3-ITD, neither Flt3-WT nor Flt3-TKD induced activation or induction of STAT5 target genes. Flt3-TKD also failed to repress c/EBPα and Pu.1. No significant differences were observed in receptor autophosphorylation and the phosphorylation of Erk-1 and -2, Akt, and Shc. Importantly, TKD but not ITD mutations were a log power more sensitive toward the tyrosine kinase inhibitor protein kinase C 412 (PKC412) than Flt3-WT. In conclusion, Flt3-ITD and Flt3-TKD mutations display differences in their signaling properties that could have important implications for their transforming capacity and for the design of mutation-specific therapeutic approaches.
Anomalously Large Equilibrium Clusters of Colloids (2001)

We propose a mechanism for mesophase separation in a system of aggregating colloids. Conditions are outlined under which colloids can form equilibrium clusters with very large sizes, i.e., aggregation numbers of a thousand or more. The driving force for clustering is a short range attractive interaction which will be treated within a capillarity approximation. The stabilizing mechanism is a small amount of charge per particle. Under the appropriate conditions these charges will interact with unscreened Coulomb potentials and, consequently, prevent large-scale phase separation.
Study of Gamma-Irradiation Effects on Chitosan Microparticles (2006)

Gamma (gamma)-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation also might affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the characteristics of chitosan microparticles was investigated. The diclofenac sodium was incorporated into chitosan microparticles by spray-drying method. The chitosan microparticles (placebo and drug-loaded) were irradiated at doses of 5, 15, and 25 kGy using a (60)Co source. Later, the microparticles were characterized by Fourier transform infrared (FTIR) spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and atomic force microscopy. In addition, microparticles also were evaluated for their sizes, drug content, swelling, and drug release behavior. Encapsulation efficiency of irradiated and nonirradiated microparticles was essentially the same. Notably, surface roughness (rms) of placebo microparticles decreased significantly after gamma-irradiation when compared with nonirradiated placebo microparticles. FTIR spectroscopy revealed that gamma-irradiation of chitosan microparticles induced neither cross-linking nor formation of new group in the chitosan matrix. EPR spectroscopy results showed that the gamma rays induced only one kind of free radical in the chitosan matrix. Size, crystallinity, and thermal properties of the chitosan microparticles did not change much after gamma-irradiation. gamma-irradiated microparticles, exhibited a slightly higher drug release rate and low swelling capacity than the nonirradiated microparticles.
Results of leucovorin and doxifluridine oral regimen in the treatment of metastatic colorectal cancer (1998)

We conducted a multicentric phase II study on advanced colorectal cancer to determine the efficacy and toxicity of oral treatment with leucovorin (LV) plus doxifluridine (5'DFUR), a novel fluoropyrimidine derivative with proven antitumor activity in different experimental models. Thirty-six outpatients with measurable disease entered the trial and received orally LV 20 mg in the morning and in the afternoon, and 2 h later 5'-DFUR 500 mg/m2 every 2 days for 3 months. Thirty-four evaluable patients underwent a total of 408 weeks of treatment. The response rate was 35%, with two complete remissions and 10 partial responses. The median survival of patients who responded to treatment (responders) was 17.1 months (range 4-32), which was significantly longer (p<0.001) than the 6.5 months (range 2-11) of the patients who did not respond (non-responders). Therefore, after 4-8 weeks of treatment, 14 patients (41%) had an improvement in their performance status and/or stabilization of pain. General toxicity was usually mild, myelo and gastrointestinal toxicity were moderate, and there was no evidence of relevant neurological toxicity. These results show that a home therapy with oral LV-5'DFUR is a safe and effective treatment regimen for metastatic colorectal carcinoma.