gebhart/patrepeval huggingface dataset:
Rate of change and other metrics: a live study of the world wide web (1997)

Caching in the World Wide Web is based on two critical assumptions: that a significant fraction of requests reaccess resources that have already been retrieved; and that those resources do not change between accesses. We tested the validity of these assumptions, and their dependence on characteristics of Web resources, including access rate, age at time of reference, content type, resource size, and Internet top-level domain. We also measured the rate at which resources change, and the prevalence of duplicate copies in the Web. We quantified the potential benefit of a shared proxycaching server in a large environment by using traces that were collected at the Internet connection points for two large corporations, representing significant numbers of references. Only 22% of the resources referenced in the traces we analyzed were accessed more than once, but about half of the references were to those multiplyreferenced resources. Of this half, 13% were to a resource that had been modifi...
Symbolic substitution applied to image processing (1987)

Optical hardware for symbolic substitution is under serious consideration for optical computing applications. We show that symbolic substitution systems can be applied to image processing. Of particular importance are (1) nonlinear filtering operations applied to shapes (morphological transformations) and to level-sliced imagery and (2) linear filtering operations applied to bit-sliced images.
Expression of Protein Tyrosine Kinases in Head and Neck Squamous Cell Carcinomas (2005)

Protein tyrosine kinases (TKs) are overexpressed in many carcinomas and sarcomas. We studied the expression of the following TKs in head and neck squamous cell carcinoma (HNSCC): platelet-derived growth factor receptor (PDGFR), c-kit, epidermal growth factor receptor (EGFR), and a serine-threonine kinase, Akt. Formalin-fixed, paraffin-embedded tumor blocks from 44 consecutive patients with primary HNSCC and 5 specimens of benign pharyngeal and laryngeal mucosa were retrieved for immunohistochemical analysis. Of the specimens, 38 enough material to stain for all 4 antibodies. The study included 21 pharyngeal (base of tongue, 14; tonsil, 6; soft palate, 1), 16 laryngeal, and 1 floor of the mouth carcinoma. All 4 kinases in the tumor samples were expressed highly (PDGFR, 95%-100%; EGFR, 38%-43%; c-kit, 50%-86%; p-Akt, 57%-81%), with EGFR, c-kit, and p-Akt significantly higher than in benign samples. None of the kinase expressions correlated with disease-free survival. The expression of kinases raises the possibility of treatment of HNSCC tyrosine and serine-threonine kinase inhibitors.
Monolithic silicon-photonic platforms in state-of-the-art CMOS SOI processes [Invited] (2018)

Integrating photonics with advanced electronics leverages transistor performance, process fidelity and package integration, to enable a new class of systems-on-a-chip for a variety of applications ranging from computing and communications to sensing and imaging. Monolithic silicon photonics is a promising solution to meet the energy efficiency, sensitivity, and cost requirements of these applications. In this review paper, we take a comprehensive view of the performance of the silicon-photonic technologies developed to date for photonic interconnect applications. We also present the latest performance and results of our "zero-change" silicon photonics platforms in 45 nm and 32 nm SOI CMOS. The results indicate that the 45 nm and 32 nm processes provide a "sweet-spot" for adding photonic capability and enhancing integrated system applications beyond the Moore-scaling, while being able to offload major communication tasks from more deeply-scaled compute and memory chips without complicated 3D integration approaches.
A Simian Replication-Defective Adenoviral Recombinant Vaccine to HIV-1 Gag (2003)

In animal models, E1-deleted human adenoviral recombinants of the serotype 5 (AdHu5) have shown high efficacy as vaccine carriers for different Ags including those of HIV-1. Humans are infected by common serotypes of human adenovirus such as AdHu5 early in life and a significant percentage has high levels of neutralizing Abs to these serotypes, which will very likely impair the efficacy of recombinant vaccines based on the homologous virus. To circumvent this problem, a novel replication-defective adenoviral vaccine carrier based on an E1-deleted recombinant of the chimpanzee adenovirus 68 (AdC68) was developed. An AdC68 construct expressing a codon-optimized, truncated form of gag of HIV-1 induces CD8(+) T cells to gag in mice which at the height of the immune response encompass nearly 20% of the entire splenic CD8(+) T cell population. The vaccine-induced immune response provides protection to challenge with a vaccinia gag recombinant virus. Induction of transgene-specific CD8(+) T cells and protection against viral challenge elicited by the AdC68 vaccines is not strongly inhibited in animals preimmune to AdHu5 virus. However, the response elicited by the AdHu5 vaccine is greatly attenuated in AdHu5 preimmune animals.
Computer Classification of Reservoir Sandstones (1973)

A procedure is developed to extract numerical features which characterize the pore structure of reservoir rocks. The procedure is based on a set of descriptors which give a statistical description of porous media. These features are evaluated from digitized photomicrographs of reservoir rocks and they characterize the rock grain structure in term of (1) the linear dependency of grey tones in the photomicrograph image, (2) the degree of "homogeneity" of the image and (3) the angular variations of the image grey tone dependencies. On the basis of these textural features, a simple identification rule using piecewise linear discriminant functions is developed for categorizing the photomicrograph images. The procedure was applied to a set of 243 distinct images comprising 6 distinct rock categories. The coefficients of the discriminant functions were obtained using 143 training samples. The remaining (100) samples were then processed, each sample being assigned to one of 6 possible sandstone categories. Eighty-nine per cent of the test samples were correctly identified.
The Physical Implementation of Quantum Computation (2000)

After a brief introduction to the principles and promise of quantum information processing, the requirements for the physical implementation of quantum computation are discussed. These five requirements, plus two relating to the communication of quantum information, are extensively explored and related to the many schemes in atomic physics, quantum optics, nuclear and electron magnetic resonance spectroscopy, superconducting electronics, and quantum-dot physics, for achieving quantum computing.
Immunoassay demonstration using a local evanescent array coupled biosensor (2010)

A Label-free optical waveguide immunosensor is investigated both theoretically and experimentally. The local evanescent array coupled (LEAC) biosensor is based on a local evanescent field shift mechanism, which differs from those of other evanescent waveguide sensors. Antigens specifically bound by immobilized antibodies on the waveguide surface increase the refractive index of the upper cladding of the waveguide, and hence shift the evanescent field distribution up. This local detection mechanism grants the LEAC sensor multi-analyte ability in a single optical path. Compared to traditional biosensors, including surface plasmon resonance and ring resonance biosensors, the nonresonant and temperature/wavelength insensitive properties of the LEAC biosensor relax its requirement on the optical source. It requires no accessory off-chip instruments such as spectrometers, making it a chip-scale biosensing platform. The on-chip detection is accomplished by integrating buried polysilicon detector arrays into silicon nitride waveguide in a commercial complementary metal oxide semiconductor (CMOS) process. Protein antigens and IgG producing biologically relevant antibody-antigen interactions were used to test the clinical utility of the LEAC biosensor platform. Advanced analysis beam propagation method (BPM) simulations and chips with different geometric parameters were used to study the relationship between the sensitivity and structure of LEAC biosensor.
Evaluation of intrathymic islet transplantation in the prediabetic period. (1992)

Prophylactic intrathymic MHC-incompatible islet allografts effectively prevent hyperglycemia and native beta-cell destruction in an animal model of autoimmune diabetes. Rejection and autoimmune destruction of intrathymic MHC-incompatible islet allografts were not seen after transplantation in the prediabetic (prehyperglycemic) period. Intrathymic islet allografts at an early age (before puberty) preserve native beta-cell function and may prevent or retard thymic atrophy.
The Effects of Vagus Nerve Stimulation on Pro- and Anti-Inflammatory Cytokines in Humans: A Preliminary Report (2005)

VNS is associated with marked peripheral increases in pro- and anti-inflammatory circulating cytokines. Such changes are unlikely to be non-specific inflammatory reactions, reflected by CRP levels. In view of gathering evidence supporting a role for the immune system in modulating affect, as well as seizure activity, these effects of VNS may be therapeutically relevant.
Azlactone-functionalized polymers as reactive platforms for the design of advanced materials: Progress in the last ten years (2011)

Polymers functionalized with azlactone (or oxazolone) functionality have become increasingly useful for the rapid and modular design of functional materials. Because azlactones can react via ring-opening reactions with a variety of different nucleophilic species (e.g., primary amines, hydroxyl groups, and thiol functionality), azlactone-functionalized materials can serve as convenient 'reactive' platforms for the post-synthesis or post-fabrication introduction of a broad range of chemical functionality to soluble polymers, insoluble supports, and surfaces/interfaces. The last decade has seen an increase in both the number and the variety of reports that exploit the properties and the reactivities of azlactone-functionalized polymers. Here, we highlight recent work from several different laboratories, including our own, toward the design and characterization of azlactone-functionalized polymers, with a particular emphasis on: (i) new synthetic approaches for the preparation of well-defined azlactone-functionalized polymers using living/controlled methods of polymerization, (ii) the design and modular synthesis of side-chain functionalized polymers and block copolymers via post-polymerization modification of azlactone-functionalized polymers, (iii) the development of reactive polymeric supports useful in the contexts of separations and catalysis, and (iv) methods for the fabrication of reactive thin films and other approaches to the immobilization of azlactone functionality on surfaces and interfaces. Examples discussed herein reveal a growing awareness of azlactone functionality as a useful tool for polymer chemists, and highlight several ways that the unique reactivity of these materials can both complement and provide useful alternatives to other reactive polymers currently used to design functional materials.
Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction (2005)

Minocycline, a tetracycline with anti-inflammatory properties, has been reported to down-regulate the activity of microglia, whose activation occurs in inflammatory and degenerative diseases of the central nervous system, such as multiple sclerosis and Alzheimer's disease. In these disorders, a T cell component is also evident, and we have demonstrated previously that the interaction of activated T cells with microglia led to the substantial increase in tumor necrosis factor alpha (TNF-alpha) levels. Here, we report that minocycline decreases TNF-alpha levels produced in human T cell-microglia interaction. This effect is mediated by a direct action of minocycline on the activated T cells and on microglia, which resulted in the decreased ability of T cells to contact microglia. In correspondence, minocycline decreased the expression on T cells of the CD40 ligand (CD40L), a key molecule regulating the contact-mediated interaction of T cells with microglia. These results demonstrate that the mechanism of action of minocycline involves not only microglia but also T cells and their subsequent activation of microglia. The capacity of minocycline to down-regulate CD40L on T cells may provide a new means to target the CD40-CD40L pathway, which regulates several inflammatory processes.
D2 dopamine receptors enable Δ9‐tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration (2000)

The systemic administration of Δ 9 ‐tetrahydrocannabinol (2.5–7.5 mg kg −1 ) reduced hippocampal extracellular acetylcholine concentration and impaired working memory in rats. Both effects were antagonized not only by the CB 1 cannabinoid receptor antagonist SR141716A (0.5 mg kg −1 , i.p.) but also unexpectedly by the D 2 dopamine receptor antagonist S(−)‐sulpiride (5, 10 and 25 mg kg −1 , i.p.). Conversely, Δ 9 ‐tetrahydrocannabinol‐induced memory impairment and inhibition of hippocampal extracellular acetylcholine concentration were potentiated by the subcutaneous administration of the D 2 dopamine receptor agonist (−)‐quinpirole (25 and 500 μg kg −1 ). The inhibition of hippocampal extracellular acetylcholine concentration and working memory produced by the combination of (−)‐quinpirole and Δ 9 ‐tetrahydrocannabinol was suppressed by either SR141716A or S(−)‐sulpiride. Our findings suggest that impairment of working memory and inhibition of hippocampal extracellular acetylcholine concentration are mediated by the concomitant activation of D 2 dopamine and CB 1 cannabinoid receptors, and that D 2 dopamine receptor antagonists may be useful in the treatment of the cognitive deficits induced by marijuana. British Journal of Pharmacology (2000) 130 , 1201–1210; doi: 10.1038/sj.bjp.0703413
A voltage‐gated potassium channel in human T lymphocytes. (1985)

Human peripheral T lymphocytes were studied at 20-24 degrees C using the gigaohm seal recording technique in whole-cell or outside-out patch conformations. The predominant ion channel present under the conditions employed was a voltage-gated K+ channel closely resembling delayed rectifier K+ channels of nerve and muscle. The maximum K+ conductance in ninety T lymphocytes ranged from 0.7 to 8.9 nS, with a mean of 4.2 nS. The estimated number of K+ channels per cell is 400, corresponding to a density of about three channels/micron2 apparent membrane area. The activation of K+ currents could be fitted by Hodgkin-Huxley type n4 kinetics. The K+ conductance in Ringer solution was half-maximal at -40 mV. The time constant of K+ current inactivation was practically independent of voltage except near the threshold for activating the K+ conductance. Recovery from inactivation was slow and followed complex kinetics. Steady-state inactivation was half-maximal at -70 mV, and was complete at positive potentials. Permeability ratios, relative to K+, determined from reversal potential measurements were: K+(1.0) greater than Rb+(0.77) greater than NH4+(0.10) greater than Cs+ (0.02) greater than Na+(less than 0.01). Currents through K+ channels display deviations from the independence principle. The limiting outward current increases when external K+ is increased, and Rb+ carries less inward current than expected from its relative permeability. Tail current kinetics were slowed about 2-fold by raising the external K+ concentration from 4.5 to 160 mM, and were 5 times slower in Rb+ Ringer solution than in K+ Ringer solution. Single K+ channel currents had two amplitudes corresponding to about 9 and 16 pS in Ringer solution. Replacing Ringer solution with isotonic K+ Ringer solution increased the unitary conductance and resulted in inward rectification of the unitary current-voltage relation. Comparable effects of external K+ were seen in the whole-cell conductance and instantaneous current-voltage relation. Several changes in the K+ conductance occurred during the first few minutes after achievement of the whole-cell conformation. Most are explainable by dissipation of a 10-20 mV junction potential between pipette solution and the cytoplasm, and by the use of a holding potential more negative than the resting potential. However, inactivation of K+ currents became faster and more complete, changes not accounted for by these mechanisms. K+ efflux through open K+ channels in intact lymphocytes, calculated from measured properties of K+ channels, can account for efflux values reported in resting lymphocytes, and for the increase in K+ efflux upon mitogenic stimulation.(ABSTRACT TRUNCATED AT 400 WORDS)
Commensal Gut Flora Drives the Expansion of Proinflammatory CD4 T Cells in the Colonic Lamina Propria under Normal and Inflammatory Conditions (2008)

We tested in B6 mice whether the local expansion of CD4 T cells producing proinflammatory cytokines including IL-17 (Th17 cells) in the colonic lamina propria (cLP) depends on the commensal microflora. High numbers of CD4 Th17 cells were found in the lamina propria of the ileum and colon but not the duodenum, jejunum, mesenteric lymph nodes, spleen, or liver of specific pathogen-free (SPF) mice. The microflora is required for the accumulation of cytokine (IL-17, IFN-gamma, TNF-alpha, IL-10)-producing CD4 T cells in the cLP because only low numbers of cytokine-producing cLP CD4 T cells were found in syngeneic (age- and sex-matched) germfree mice. The fraction of cLP Th17 cells was higher in (type I and type II) IFN- but not IL-4- or IL-12p40-deficient SPF congenics. cLP CD4 Th17 cells produce IL-17 but not IFN-gamma, TNF-alpha, IL-4, or IL-10. cLP CD4 Th17 cells accumulate locally in colitis induced by adoptive transfer of IFN-gamma+/+ or IFN-gamma-/- CD4 T cells into congenic SPF (but not germfree) RAG-/- hosts. In this colitis model, cLP CD4 T cells that "spontaneously" produce IL-17 progressively increase in number in the inflamed cLP, and increasing serum IL-17 levels appear as the disease progresses. Commensal bacteria-driven, local expansion of cLP CD4 Th17 cells may contribute to the pathogenesis of this inflammatory bowel disease.
A 0.24 μm SiGe BiCMOS mixed-signal RF production technology featuring a 47 GHz f/sub t/ HBT and 0.18 μm L/sub ett/ CMOS (2003)

A new base-after-gate integration scheme has been developed to integrate a 47 GHz f/sub t/, 65 GHz F/sub max/SiGe HBT process with a 0.24 /spl mu/m CMOS technology having 0.18 /spl mu/m L/sub eff/ and 5 nm gate oxide. We discuss the benefits and challenges of this integration scheme which decouples the HBT from the CMOS thermal cycles. We also describe the resulting 0.24 /spl mu/m SiGe BiCMOS technology, BiCMOS 6HP, which includes a 7 nm dual gate oxide option and full suite of passive components. The technology provides a high level of integration for mixed-signal RF applications.
New sequence motifs in flavoproteins: Evidence for common ancestry and tools to predict structure (2000)

We describe two new sequence motifs, present in several families of flavoproteins. The "GG motif" (RxGGRxxS/T) is found shortly after the betaalphabetadinucleotide-binding motif (DBM) in L-amino acid oxidases, achacin and aplysianin-A, monoamine oxidases, corticosteroid-binding proteins, and tryptophan 2-monooxygenases. Other disperse sequence similarities between these families suggest a common origin. A GG motif is also found in protoporphyrinogen oxidase and carotenoid desaturases and, reduced to the central GG doublet, in the THI4 protein, dTDP-4-dehydrorhamnose reductase, soluble fumarate reductase, steroid dehydrogenases, Rab GDP-dissociation inhibitor, and in most flavoproteins with two dinucleotide-binding domains (glutathione reductase, glutamate synthase, flavin-containing monooxygenase, trimethylamine dehydrogenase...). In the latter families, an "ATG motif" (oxhhhATG) is found in both the FAD- and NAD(P)H-binding domains, forming the fourth beta-strand of the Rossman fold and the connecting loop. On the basis of these and previously described motifs, we present a classification of dinucleotide-binding proteins that could also serve as an evolutionary scheme. Like the DBM, the ATG motif appears to predate the divergence of NAD(P)H- and FAD-binding proteins. We propose that flavoproteins have evolved from a well-differentiated NAD(P)H-binding protein. The bulk of the substrate-binding domain was formed by an insertion after the fourth beta-strand, either of a closely related NAD(P)H-binding domain or of a domain of completely different origin.
MPEG-4 Enhanced Low Delay AAC - A New Standard for High Quality Communication (2008)

The MPEG Audio standardization group has recently concluded the standardization process for the MPEG-4 ER Enhanced Low Delay AAC (AAC-ELD) codec. This codec is a new member of the MPEG Advanced Audio Coding family. It represents the efficient combination of the AAC Low Delay codec and the Spectral Band Replication (SBR) technique known from HE-AAC. This paper provides a complete overview of the underlying technology, presents points of operation as well as applications, and discusses MPEG verification test results.
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins (1997)

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid p7 protein contains two retrovirus-type zinc finger domains that are required for multiple phases of viral replication. Chelating residues (three Cys residues and one His residue) of the domains are absolutely conserved among all strains of HIV-1 and other retroviruses, and mutations in these residues in noninfectious virions. These properties establish the zinc finger domains as logical targets for antiviral chemotherapy. Selected dithiobis benzamide (R-SS-R) compounds were previously found to inhibit HIV-1 replication by mediating an electrophilic attack on the zinc fingers. Unfortunately, reaction of these disulfide-based benzamides with reducing agents yields two monomeric structures (two R-SH structures) that can dissociated and no longer react with the zinc fingers, suggesting that in vivo reduction would inactivate the compounds. Through an extensive drug discovery program of the National Cancer Institute, a nondissociable tethered dithiane compound (1,2-dithiane-4,5-diol, 1,1-dioxide, cis; NSC 624151) has been identified. This compound specifically attacks the retroviral zinc fingers, but not other antiviral targets. The lead compound demonstrated broad antiretroviral activity, ranging from field isolates and drug-resistant strains of HIV-1 to HIV-2 and simian immunodeficiency virus. The compound directly inactivated HIV-1 virions and blocked production of infectious virus from cells harboring integrated proviral DNA. NSC 624151 provides a scaffold from which medicinal chemists can develop novel compounds for the therapeutic treatment of HIV infection.