gebhart/patrepeval huggingface dataset:
Technology evaluation: adalimumab, Abbott laboratories. (2002)

Adalimumab (D2E7), a human monoclonal antibody that binds to and neutralizes TNFa, is being developed by Abbott (formerly Knoll), under license from Cambridge Antibody Technology (CAT), for the potential treatment of inflammatory disorders such as rheumatoid arthritis (RA) and Crohn's disease. It is also being investigated for the potential treatment of coronary heart disease. Phase II studies for Crohn's disease and phase III for RA were ongoing throughout 2001. Limited data are only available for RA. In January 2002, it was reported that phase III trials of adalimumab for RA had been completed, but details have not been published in the primary literature so far. At this time CAT and Abbott expected to file for US approval in the second quarter of 2002 with a launch date anticipated for 2003. Phase III data are expected to be presented at the European League Against Rheumatism meeting in June 2002. In November 2000, Lehman Brothers predicted a US launch in June 2002 with peak US sales of $600 million in 2007 and a launch in non-US markets in 2003 with peak sales in these markets of $300 million in 2008. In December 2000, Merrill Lynch predicted regulatory clearance in the second half of 2003. The probability of adalimumab reaching the market is estimated to be 70%. In December 2000, Merrill Lynch predicted a 2003 launch, with estimated sales of pounds sterling 3.65 million in that year rising to pounds sterling 30.14 million in 2010. In March 2001, ABN AMRO predicted sales of $73 million in 2003 rising to $392 million in 2007.
The High‐producing Dairy Cow and its Reproductive Performance (2007)

There is evidence that the reproductive performance of dairy cows has declined as milk yields have increased over the last 40 years. Identifying the precise cause(s) of this problem may provide focused solutions. Intensive genetic selection for very high yields has reduced fertility, due mainly to an increase in postpartum clinical problems, poor expression of oestrus, defective oocytes/embryos and uterine infections. It is a challenge to solve the problem by getting enough food into these cows to meet the high demands of peak milk yields in early lactation, as well as providing the considerable veterinary attention required in the early period after calving. Both these aspects also pose welfare issues. A better solution would be to make genetic and management changes to increase the persistency of lactations to reduce the number and intensity of clinical risk periods throughout a cow's life without compromising milk output.
Design of Wireless Communication Systems -- Issues on Synchronization, Channel Estimation and Multi-Carrier Systems (2000)

This thesis deals with certain aspects in the design of wireless communications systems. It is focused on problems related to the mobile or wireless channel: synchronization, channel estimation and design of wireless orthogonal frequency division multiplex (OFDM) systems. There is a short introduction to the field of wireless systems and a deeper review of pervious work and the state of the art in each of the research fields. Throughout the thesis the goal has been to analyze the problems analytically, deriving expressions for the resulting bit error rate (BER) or synchronization performance. The work on channel estimation is focused on the influence of the pilot pattern in OFDM systems and on the possibility of compensating the signal in advance for impairments introduced by the channel. The BER is derived and compared when using different pilot patterns in an OFDM system. For the pre-compensated system the BER, maximum block length, and resulting peak-to-average power ratio are investigated when compensating the power attenuation and/or the phase rotation introduced by the channel. The work on wireless OFDM system design is directed towards preamble-based synchronization and optimization of the sub-channel bandwidth. A new synchronizer structure is introduced for time and frequency synchronization. In this synchronizer the order of correlation and multiplication has been changed compared to conventional synchronizers, which results in significantly improved detection performance. The sub-channel bandwidth is optimized based on the expected Doppler frequency and excess delay of the channel. The use of superimposed pilot sequences is introduced for time and frequency synchronization in OFDM systems, as well as for channel estimation in flat fading channels. As opposed to conventional pilot-based systems, the pilot sequence is linearly added to the data sequence and therefore transmitted simultaneously and in the same band as the data sequence. The performance when using superimposed pilot sequences for synchronization and for joint channel estimation and detection is analyzed. The scheme is also compared to other well known pilot-based and differential detection methods.
Thermosetting Polymers (2002)

Provides comprehensive coverage of the most recent developments in the theory of non-Archimedean pseudo-differential equations and its application to stochastics and mathematical physics--offering current methods of construction for stochastic processes in the field of p-adic numbers and related structures. Develops a new theory for parabolic equat
Tying Word Vectors and Word Classifiers: A Loss Framework for Language Modeling (2016)

Recurrent neural networks have been very successful at predicting sequences of words in tasks such as language modeling. However, all such models are based on the conventional classification framework, where the model is trained against one-hot targets, and each word is represented both as an input and as an output in isolation. This causes inefficiencies in learning both in terms of utilizing all of the information and in terms of the number of parameters needed to train. We introduce a novel theoretical framework that facilitates better learning in language modeling, and show that our framework leads to tying together the input embedding and the output projection matrices, greatly reducing the number of trainable variables. Our framework leads to state of the art performance on the Penn Treebank with a variety of network models.
Nitrogen Adsorption in Carbon Aerogels:  A Molecular Simulation Study (2002)

We present a molecular model for carbon aerogel in which the mesopore space is represented by carbon spheres in a connected network. This matrix was prepared by first generating a random close-packed structure of slightly overlapping spheres, followed by removal of spheres to match the targeted porosity, while maintaining connectivity. The spheres were then replaced by a model microporous carbon generated by applying the Reverse Monte Carlo method to fit the experimental carbon radial distribution function, g(r), obtained by X-ray diffraction. The resulting model aerogel had a surface area, porosity, and pore size distribution that closely matches that of the experimental material. We used a parallelized Grand Canonical Monte Carlo algorithm to study nitrogen adsorption in this model aerogel. The resulting adsorption isotherm shows satisfactory agreement with the experimental results. Adsorption occurred in the micropores at very low pressure, followed by adsorption in the mesopores, with capillary condensation occurring at the higher pressures.
Simultaneous EEG and fMRI of the alpha rhythm (2002)

The alpha rhythm in the EEG is 8–12 Hz activity present when a subject is awake with eyes closed. In this study, we used simultaneous EEG and fMRI to make maps of regions whose MRI signal changed reliably with modulation in posterior alpha activity. We scanned 11 subjects as they rested with eyes closed. We found that increased alpha power was correlated with decreased MRI signal in multiple regions of occipital, superior temporal, inferior frontal, and cingulate cortex, and with increased signal in the thalamus and insula. These results are consistent with animal experiments and point to the alpha rhythm as an index of cortical inactivity that may be generated in part by the thalamus. These results also may have important implications for interpretation of resting baseline in fMRI studies.
A Novel Protein Distinguishes between Quiescent and Activated Forms of the Type I Transforming Growth Factor β Receptor (1998)

Transforming growth factor beta (TGFbeta) signal transduction is mediated by two receptor Ser/Thr kinases acting in series, type II TGFbeta receptor (TbetaR-II) phosphorylating type I TGFbeta receptor (TbetaR-I). Because the failure of interaction cloning, thus far, to identify bona fide TbetaR-I substrates might reasonably have been due to the use of inactive TbetaR-I as bait, we sought to identify molecules that interact specifically with active TbetaR-I, employing the triple mutation L193A,P194A,T204D in a yeast two-hybrid system. The Leu-Pro substitutions prevent interaction with FK506-binding protein 12 (FKBP12), whose putative function in TGFbeta signaling we have previously disproved; the charge substitution at Thr204 constitutively activates TbetaR-I. Unlike previous screens using wild-type TbetaR-I, where FKBP12 predominated, none of the resulting colonies encoded FKBP12. A novel protein was identified, TbetaR-I-associated protein-1 (TRAP-1), that interacts in yeast specifically with mutationally activated TbetaR-I, but not wild-type TbetaR-I, TbetaR-II, or irrelevant proteins. In mammalian cells, TRAP-1 was co-precipitated only by mutationally activated TbetaR-I and ligand-activated TbetaR-I, but not wild-type TbetaR-I in the absence of TGFbeta. The partial TRAP-1 protein that specifically binds these mutationally and ligand-activated forms of TbetaR-I can inhibit signaling by the native receptor after stimulation with TGFbeta or by the constitutively activated receptor mutation, as measured by a TGFbeta-dependent reporter gene. Thus, TRAP-1 can distinguish activated forms of the receptor from wild-type receptor in the absence of TGFbeta and may potentially have a functional role in TGFbeta signaling.
Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors (1992)

A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1-P1' position have been synthesized and studied both in vitro and in vivo. In vitro, the compounds were evaluated as inhibitors of monkey renin and the closely related aspartic proteinase, cathepsin D (bovine), as a measure of enzyme selectivity. Interestingly, the difluoroketone derivatives showed greatly reduced selectivity compared with the corresponding alcohols. However, selectivity could be enhanced by judicious choice of other substituents. Sites influencing selectivity, included not only P2, which is well-known to strongly affect selectivity, but also the P4, P1-P1', and P2' sites. These results make possible the design of inhibitors with a greater selectivity for either renin versus cathepsin D. In vivo several of the compounds in the difluoroketone series have shown good oral activity in the salt depleted normotensive cynomolgus monkey model.
Making faces (2006)

We have created a system for capturing both the three-dimensional geometry and color and shading information for human facial expressions. We use this data to reconstruct photorealistic, 3D animations of the captured expressions. The system uses a large set of sampling points on the face to accurately track the three dimensional deformations of the face. Simultaneously with the tracking of the geometric data, we capture multiple high resolution, registered video images of the face. These images are used to create a texture map sequence for a three dimensional polygonal face model which can then be rendered on standard 3D graphics hardware. The resulting facial animation is surprisingly life-like and looks very much like the original live performance. Separating the capture of the geometry from the texture images eliminates much of the variance in the image data due to motion, which increases compression ratios. Although the primary emphasis of our work is not compression we have investigated the use of a novel method to compress the geometric data based on principal components analysis. The texture sequence is compressed using an MPEG4 video codec. Animations reconstructed from 512x512 pixel textures look good at data rates as low as 240 Kbits per second.
Reliability of tunneling magnetoresistance recording head-lifetime, failure mode, and production screening (2006)

We have studied the behavior of failure in lifetime acceleration test of TMR prototype with performance meeting 100 Gb/in/sup 2/ recording. The failure mode is identified to be same as extrinsic breakdown of the AlOx barrier, while failure due to magnetic change is not observed. The extrinsic breakdown is further found to be the increase in pinhole conduction in the barrier, involving thermal energy from ambient and read current. Results also suggest the existence of a critical voltage below which pinhole is not enlarged. Furthermore, we will discuss our hypothesis in the formation of pinholes and the role of charge traps in the barrier. Finally, we will discuss a method for screening out heads with relatively short lifetime, which is feasible for mass production. The screening allows a guarantee of lifetime well enough for drive application.
Serologic Evidence of an Association between Enteroviruses and the Onset of Type 1 Diabetes Mellitus (1995)

Serum was collected from 128 patients < or = 18 years of age admitted to the Children's Hospital of Pittsburgh with new-onset insulin-dependent diabetes mellitus (IDDM) and from 120 control-patients who were frequency-matched to case-patients for age, sex, and date of bleed. Serum was tested for IgM against 14 enterovirus serotypes: coxsackieviruses B1-B6 and A9, echoviruses 4, 6, 9, 11, 30, and 34, and enterovirus 71. Case-children 13-18 years of age were more likely than control-patients to be IgM-positive for 9 of 14 serotypes (P < or = .05 for each). In contrast, case-children 10-12 years of age and 1-9 years of age were each more likely than age-matched control-children to be IgM positive for 1 serotype (P < or = .05 for each). In addition, the association between IgM positivity and IDDM occurred earlier in girls than in boys. These data support an association between IDDM and enterovirus IgM positivity in older children.
Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. (2012)

With rapid development of sequencing technologies such as deep sequencing and whole genome high-density tiling array, we now know that most of the "junk" genomic sequences are transcribed as non-coding RNAs (ncRNAs). A large number of long ncRNA transcripts (> 200bp) have been identified, and these long ncRNAs (LncRNAs) are found to be crucial regulators for epigenetic modulation, transcription, and translation. In this review, we briefly summarize the regulatory function of LncRNAs with a particular focus on the underlying mechanisms of LncRNAs in oncogenesis, tumor metastasis and suppression.
Transient receptor potential channels as drug targets (2007)

The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney. TRP channels are a relatively new target in therapeutic drug discovery. During the past few years, pharmaceutical companies have focused their discovery efforts on developing TRP channel modulators with potential therapeutic value. This review focuses on the potential therapeutic benefits of drugs targeting TRP ion channels.
Cryptosporidium parvum Infection in Gene-Targeted B Cell–Deficient Mice (2003)

The importance of B cells in host resistance to, and recovery from, Cryptosporidium parvum infection was examined in gene-targeted B cell-deficient (muMT-/-) mice. Neonatal muMT-/- mice infected with C. parvum at 5 days of age completely cleared the infection by day 20 PI. The kinetics of infection and clearance were similar to those seen with age-matched C57BL/6 control mice. Furthermore, B cells were not required to clear existing C. parvum infection in adult mice. Reconstitution of persistently infected Rag-1-/- adult mice with spleen cells from muMT-/- donor mice resulted in significant reduction of infection, as in the results seen with spleen cells from C57BL6 donors. These findings indicate clearly that B cells are not essential for host resistance to, and recovery from, C. parvum infection in mice.
Clinical Practice (1990)

Department Editor Neck Masses Linda Williams, BSN, RN, CPSN, is Nursing Supenisor at the Center for Plastic and Reconstructive Surgery in Orlando, FL. Frank Stieg, JD, MD, is a partner at the Center for Plastic and Reconstructive Surgery, Orlando, FL.
Solidification study of commercial magnesium alloys (2009)

In this thesis, the solidification behaviors of AZ9ID, AM60B and AE44 commercial magnesium alloys have been studied experimentally by differential scanning calorimeter (DSC) and optical microscopy. The effect of different cooling rates on the transition temperatures and microstructures were analyzed. It was found that the effect of cooling rate on the solidus temperature is more significant than on the liquidus. The solidus temperature decreases clearly with increasing cooling rates, but for the liquidus temperature there is slightly increasing trend. The latent heat of solidification was also calculated and found that it increases when the cooling rate increases. Thermodynamic calculations were made using FactSage along with VLGM database and were compared with the experimental findings as well as with the literature data. Thermodynamic calculations were also utilized to understand the microstructures as well as the phase distribution. The microstructural details of as-cast and post-DSC samples have also been investigated using optical microscope. Finally, relationships between cooling rate and transition temperature as well as between cooling rate and latent heat of solidification have been established based on the general power law. Using these relationships it is possible to predict the transition temperatures and latent heat of solidification of these alloys at high cooling rates
Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells (2011)

The production of reactive aldehydes such as 4-hydroxy-2-nonenal (4-HNE) is a key component of the pathogenesis in a spectrum of hepatic diseases involving oxidative stress such as alcoholic liver disease (ALD). One consequence of ALD is increased insulin resistance in hepatocytes. To understand the effects of 4-HNE on insulin signaling in liver cells, we employed a model using hepatocellular carcinoma cell line HepG2. Previously, we have demonstrated an increase in the level of Akt phosphorylation is mediated by 4-HNE inhibition of PTEN, a direct regulator of Akt. In this work, we evaluated the effects of 4-HNE on insulin-dependent stimulation of the Akt2 pathway. We demonstrate that 4-HNE selectively leads to phosphorylation of Akt2. Although Akt2 is phosphorylated following 4-HNE treatment, the level of downstream phosphorylation of Akt substrates such as GSK3β and MDM2 is significantly decreased. Pretreatment with 4-HNE prevented insulin-dependent Akt signaling and decreased intracellular Akt activity by 87%. Using biotin hydrazide capture, it was confirmed that 4-HNE treatment of cells resulted in carbonylation of Akt2, which was not observed in untreated control cells. Using a synthetic GSK3α/β peptide as a substrate, treatment of recombinant human myristoylated Akt2 (rAkt2) with 20 or 40 μM 4-HNE inhibited rAkt2 activity by 30 or 85%, respectively. Matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF) identified Michael addition adducts of 4-HNE with His196, His267, and Cys311 of rAkt2. Computation-based molecular modeling analysis of 4-HNE adducted to His196 and Cys311 of Akt2 suggests inhibition of GSK3β peptide binding by 4-HNE in the Akt2 substrate binding pocket. The inhibition of Akt by 4-HNE provides a novel mechanism for increased insulin resistance in ALD. These data provide a potential mechanism of dysregulation of Akt2 during events associated with sustained hepatocellular oxidative stress.
The interaction of architecture and operating system design (1991)

article Free Access Share on The interaction of architecture and operating system design Authors: Thomas E. Anderson View Profile , Henry M. Levy View Profile , Brian N. Bershad View Profile , Edward D. Lazowska View Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 25Issue Special IssueApr. 1991pp 108–120https://doi.org/10.1145/106974.106985Published:01 April 1991Publication History 194citation2,544DownloadsMetricsTotal Citations194Total Downloads2,544Last 12 Months293Last 6 weeks55 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
ERWIN: an E-region wind interferometer (1996)

A field-widened Michelson interferometer designed to measure upper atmospheric winds at three altitudes near the mesopause by using airglow emissions from O(1)S, OH, and O(2) is described. A very large path difference (11 cm) is used to suppress the fringes from the hot F-region emission of O(1)S and to facilitate accurate measurements. Field widening and thermal compensation are achieved over the large spectral range (557.7-866.0 nm) by the use of three types of glass in the interferometer's arms. The instrument was installed at Resolute Bay, Canada (74.3 N, 94.5 W), in November 1992 and has been operated remotely from Toronto for four winter seasons. Some examples of data are shown to illustrate ERWIN's performance.
Relaxometry of Tissue (2007)

The sections in this article are 1 Introduction 2 Proton 1/ T 1 NMRD Profiles of Tissue and Model Systems 3 Proton and Deuteron NMRD Profiles in Model Systems with Deuterated Solvent 4 Theory 5 Data and Theory 6 Cytoplasmic Ordering and Cytoplasmic Chaos 7 Perspectives 8 Biographical Sketches Related Articles
Hierarchical Multi-Channel Audio Coding Based On Time-Domain Linear Prediction (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Quantification of Fungal DNA by Using Fluorescence Resonance Energy Transfer and the Light Cycler System (2000)

The Light Cycler technique combines rapid in vitro amplification of DNA in glass capillaries with real-time species determination and quantification of DNA load. We have established a quantitative PCR protocol for two clinically important pathogens, Candida albicans and Aspergillus fumigatus. The sensitivity of the assay was comparable to those of previously described PCR protocols (5 CFU/ml). Specific detection of C. albicans and A. fumigatus could be achieved. The assay showed a high reproducibility of 96 to 99%. The assay was linear in a range between 10(1) and 10(4) Aspergillus conidia. As capillaries do not have to be reopened for post-PCR analysis, the risk of carryover contaminations could be minimized. The Light Cycler allowed quantification of the fungal loads in a limited number of clinical specimens from patients with hematological malignancies and histologically proven invasive fungal infections. Five of nine positive samples had fungal loads between 5 and 10 CFU/ml of blood, two of nine positive samples had fungal loads between 10 and 100 CFU/ml of blood, and two of nine samples had fungal loads of more than 100 CFU/ml of blood. All samples were also found to be PCR positive by PCR-enzyme-linked immunosorbent assay analysis.