gebhart/patrepeval huggingface dataset:
Hydroxyacetophenone Derivatives from Baccharis glutinosa (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxyacetophenone Derivatives from Baccharis glutinosaX. A. Dominguez, S. El Dahmi, and C. RomboldCite this: J. Nat. Prod. 1986, 49, 1, 143–144Publication Date (Print):January 1, 1986Publication History Published online1 July 2004Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/np50043a019https://doi.org/10.1021/np50043a019research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glucagon‐like peptide‐1 analogue, liraglutide, improves liver fibrosis markers in obese women with polycystic ovary syndrome and nonalcoholic fatty liver disease (2013)

Treatment with liraglutide, and/or associated weight loss, significantly reduced PIIINP levels in obese women with PCOS. This may be an additional beneficial factor when considering the use of liraglutide in women with PCOS, obesity and NAFLD.
Naphthyl-Fused π-Elongated Porphyrins for Dye-Sensitized TiO2 Cells (2008)

Novel unsymmetrically π-elongated porphyrins, in which the naphthyl moiety is fused to the porphyrin core at the naphthyl bridge with a carboxyl group (fused-Zn-1) or at the opposite side of the phenyl bridge with a carboxyl group (fused-Zn-2), have been synthesized to improve the light-harvesting abilities in porphyrin-sensitized solar cells. As the results of π-elongation with low symmetry, Soret and Q bands of fused-Zn-1 and fused-Zn-2 were red-shifted and broadened, and the intensity of Q-band relative to that of Soret band was enhanced. The fused-Zn-1 and fused-Zn-2-sensitized TiO2 solar cells showed the power conversion efficiencies (η) of 4.1% and 1.1%, respectively, under standard AM 1.5 conditions. The η value of the fused-Zn-1 cell was improved by 50% compared to the reference cell using unfused porphyrin (Zn-1). The fused-Zn-1-sensitized cell revealed high IPCE (incident photon-to-current efficiency) values of up to 55%, extending the response of photocurrent generation close to 800 nm. Thus, the improved photocurrent generation of the fused-Zn-1-sensitized cell relative to the Zn-1-sensitized reference cell is responsible for the remarkable difference in the η values. The η value of the fused-Zn-2 cell was much lower than that of the fused-Zn-1 cell. DFT calculations disclosed that there are significant electron densities on the carboxyl group in the LUMO of fused-Zn-1, whereas there are little electron densities on the carboxyl group in the LUMO of fused-Zn-2. Accordingly, the larger electronic coupling between the porphyrin and the TiO2 surface in the fused-Zn-1-sensitized cell may be responsible for the high cell performance, due to the efficient electron injection from the porphyrin excited singlet state to the conduction band of the TiO2 electrodes. To further improve the cell performance, 5-(4-carboxylphenyl)-10,15,20-tetrakis-(2,4,6-trimethylphenyl)porphyrinatozinc(II) (Zn-3), possessing different light-harvesting properties, was coadsorbed with fused-Zn-1 onto an TiO2 electrode. Under the optimized conditions, the cosensitized cell yielded maximal IPCE value of 86%, short circuit photocurrent density of 11.7 mA cm−2, open-circuit voltage of 0.67 V, fill factor of 0.64, and η of 5.0% under standard AM 1.5 conditions.
Using Farmer Storytelling to Build Understanding of Our "New Weather Reality" (2019)

A storytelling session was successful in raising awareness and understanding of the types of changes in weather patterns farmers are experiencing in Maine, what impacts those changes are having on their operations, and the changes farmers are making in response. Using an outreach approach rooted in farmer stories allowed us to bypass the controversy that often surrounds topics related to climate change. Likewise, focusing on the farmers' experiences and avoiding corrective statements during this introductory session resulted in productive dialogue. We recommend replicating this approach within different agricultural sectors to increase understanding of sector-specific risks and strategies for adaptation.
Computational design of a self-assembling symmetrical β-propeller protein (2014)

The modular structure of many protein families, such as β-propeller proteins, strongly implies that duplication played an important role in their evolution, leading to highly symmetrical intermediate forms. Previous attempts to create perfectly symmetrical propeller proteins have failed, however. We have therefore developed a new and rapid computational approach to design such proteins. As a test case, we have created a sixfold symmetrical β-propeller protein and experimentally validated the structure using X-ray crystallography. Each blade consists of 42 residues. Proteins carrying 2-10 identical blades were also expressed and purified. Two or three tandem blades assemble to recreate the highly stable sixfold symmetrical architecture, consistent with the duplication and fusion theory. The other proteins produce different monodisperse complexes, up to 42 blades (180 kDa) in size, which self-assemble according to simple symmetry rules. Our procedure is suitable for creating nano-building blocks from different protein templates of desired symmetry.
The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System (1987)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
Synthesis and sonication-induced assembly of Si-DDR particles for close-packed oriented layers (2013)

Here, we report a seeded growth protocol for synthesizing monodisperse Si-DDR particles of ~1.3-10 μm by varying the seed amount. These Si-DDR particles were deposited onto porous α-Al2O3 discs via sonication-induced assembly, constituting close-packed h0h-oriented layers.
Evidence suggesting a role for hydroxyl radical in passive Heymann nephritis in rats (1988)

We examined the effect of scavengers of reactive oxygen metabolites on proteinuria in the passive Heymann nephritis model of membranous nephropathy. Passive Heymann nephritis was induced by a single intravenous injection of anti-Fx1A IgG in a dose of 10 mg/100 g body weight. Superoxide dismutase, a scavenger of superoxide or catalase which destroys hydrogen peroxide, did not affect the proteinuria. In contrast, dimethylthiourea (DMTU, 500 mg/kg followed by 125 mg/kg ip twice a day), a scavenger of hydroxyl radical, markedly reduced the proteinuria (day 5: anti-Fx1A 53 +/- 13, n = 18; anti-Fx1A + DMTU, 21 +/- 6 mg/24 h, n = 15, P less than 0.001). Experiments with 125I-labeled anti-Fx1A antibody demonstrated that DMTU did not affect the amount of antibody deposited in the kidney. Semiquantitative estimation of IgG and complement deposition in the kidney showed no differences between the DMTU-treated and control rats. A second hydroxyl radical scavenger, sodium benzoate (150 mg/kg ip twice a day), also resulted in marked reduction in proteinuria (day 5: anti-Fx1A 56 +/- 7, n = 9; anti-Fx1A + benzoate, 14 +/- 4 mg/24 h, n = 8, P less than 0.01). Because of the participation of iron in biological systems to generate hydroxyl radical, we also examined the effect of deferoxamine (DFO, 35 mg/day), an iron chelator, on the anti-Fx1A-induced proteinuria. There was a significant reduction in proteinuria in rats treated concurrently with DFO (day 5: anti-Fx1A 67 +/- 13, n = 15; anti-Fx1A + DFO, 29 +/- 4 mg/24 h, n = 15, P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Regulation of osteoblastogenesis and bone mass by Wnt10b (2005)

Wnts comprise a family of secreted signaling proteins that regulate diverse developmental processes. Activation of Wnt signaling by Wnt10b inhibits differentiation of preadipocytes and blocks adipose tissue development; however, the effect of Wnt10b on other mesenchymal lineages has not been defined. To explore the physiological role of Wnt signaling in bone development, we analyzed FABP4-Wnt10b mice, which express the Wnt10b transgene in marrow. Femurs from FABP4-Wnt10b mice have almost four times as much bone in the distal metaphyses and are mechanically stronger. These mice maintain elevated bone mass at least through 23 months of age. In addition, FABP4-Wnt10b mice are protected from the bone loss characteristic of estrogen deficiency. We used pharmacological and genetic approaches to demonstrate that canonical Wnt signaling stimulates osteoblastogenesis and inhibits adipogenesis of bipotential mesenchymal precursors. Wnt10b shifts cell fate toward the osteoblast lineage by induction of the osteoblastogenic transcription factors Runx2, Dlx5, and osterix and suppression of the adipogenic transcription factors C/EBPalpha and PPARgamma. One mechanism whereby Wnt10b promotes osteoblastogenesis is suppression of PPARgamma expression. Finally, Wnt10b-/- mice have decreased trabecular bone and serum osteocalcin, confirming that Wnt10b is an endogenous regulator of bone formation.
The Effect of Dehydroepiandrosterone Combined with a Low‐Fat Diet in Spontaneously Obese Dogs: A Clinical Trial (1998)

Dehydroepiandrosterone (DHEA) has been shown to have antiobesity activity in rodents and spontaneously obese dogs. This study evaluated the effect of DHEA or placebo combined with a low-fat/high-fiber diet in spontaneously obese dogs in a clinical trial. Spontaneously obese, euthyroid dogs, referred to the University of Wisconsin School of Veterinary Medicine for treatment of their obesity, were evaluated for percent overweight, rate of weight loss, serum cholesterol, plasma lipoprotein and serum biochemistry profiles, complete blood count, and endocrine profiles (T4, T3, cortisol, insulin, and DHEA-sulfate). DHEA-treated dogs had a significantly increased rate of actual and percent excess weight loss compared with placebo-treated dogs. Serum cholesterol decreased in both treatment groups; however, DHEA-treated dogs had a significantly greater reduction than placebo-treated dogs. DHEA-treated dogs had a significant 32% reduction in total plasma cholesterol, which was due to a 27% reduction in the lipoprotein fraction containing the high-density lipoprotein (HDL) and a 50% reduction in the lipoprotein fraction containing the low-density lipoprotein (LDL). Placebo-treated dogs did not have a significant reduction in total plasma cholesterol or in the fraction containing LDL; however, they did have a significant 11% reduction in the fraction containing HDL. Significant decreases in serum T4 and T3 observed in dogs receiving DHEA were not noted in dogs receiving placebo. DHEA in combination with caloric restriction results in a faster rate of weight loss than does caloric restriction alone. In addition, DHEA has hypocholesterolemic activity, particularly affecting the lipoprotein fraction containing the LDL cholesterol.
Identification of a new microRNA expression profile as a potential cancer screening tool (2010)

There is potential utility of screening for lung cancer with miRNA expression profiles. Future work will focus on the sensitivity of such miRNA expression profiles in screening sputum for lung cancer, which can be performed in real time.
Versioning in a Software Engineering Database — the Change Oriented Way (1993)

During development and maintenance of software systems, there are a number of basic facilities that have to be available to the &amp;quot;software engineer&amp;quot;. These include some form of persistent storage of data, and support for managing evolution of stored data.
Articular cartilage volume in the knee: semiautomated determination from three-dimensional reformations of MR images. (1996)

Semiautomated quantification of knee articular cartilage from MR images yields highly accurate cartilage volumes.
Uniform Nonspherical Colloidal Particles with Tunable Shapes (2007)

A framework for large-scale synthesis of a variety of uniform nonspherical particle types (see figure) is introduced. The technique involves controlling the directionality of phase separations in the seeded-polymerization technique by manipulating the crosslinking density gradients of the dimer seed particles, thus allowing the obtainment of novel nonspherical particle shapes and the production of sufficient quantities to characterize their bulk properties.
3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors (2014)

The chromatin remodeling amine oxidase lysine-specific demethylase 1 (LSD1) has become an attractive target for the design of specific inhibitors with therapeutic potential. We, and others, have described LSD1 inhibitors that have potential as antitumor agents. Many of the currently known LSD1 inhibitors are poor drug candidates, or are structurally based on the tranylcypromine backbone, thus increasing the potential for off-target effects mediated by other amine oxidases. We now describe a series of potent LSD1 inhibitors based on a novel 1,2,4-triazole scaffold; these inhibitors show a high degree of specificity for LSD1 in vitro, and cause increases in cellular histone 3 dimethyllysine 4 (H3K4me2), a gene transcription activating mark. Importantly, these inhibitors are not toxic to mammalian cells in vitro, and thus they may show utility in the treatment of epigenetically-based diseases where cell death is not a desired endpoint Figure 1. Structures of LSD1 inhibitors <b>1</b>, verlindamycin <b>2</b>, (bis)thioureas <b>3</b>, amidoxime <b>4</b>, cyclic peptide <b>5</b>, N<sup>3</sup>-(2-chloro-6-phenoxybenzyl)-4H-1,2,4-triazole-3,5-diamine <b>6</b> and N<sup>3</sup>,N<sup>5</sup>-bis(2-methoxybenzyl)-1H-1,2,4-triazole-3,5-diamine <b>7</b>.
The placental problem: Linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia (2004)

The placenta is a remarkable organ. In normal pregnancy its specialized cells (termed cytotrophoblasts) differentiate into various specialized subpopulations that play pivotal roles in governing fetal growth and development. One cytotrophoblast subset acquires tumor-like properties that allow the cells to invade the decidua and myometrium, a process that attaches the placenta to the uterus. The same subset also adopts a vascular phenotype that allows these fetal cells to breach and subsequently line uterine blood vessels, a process that channels maternal blood to the rest of the placenta. In the pregnancy complication preeclampsia, which is characterized by the sudden onset of maternal hypertension, proteinuria and edema, cytotrophoblast invasion is shallow and vascular transformation incomplete. These findings, together with very recent evidence from animal models, suggest that preeclampsia is associated with abnormal placental production of vasculogenic/angiogenic substances that reach the maternal circulation with the potential to produce at least a subset of the clinical signs of this syndrome. The current challenge is to build on this knowledge to design clinically useful tests for predicting, diagnosing and treating this dangerous disorder.
Cardiovascular actions of atrial natriuretic factor in sheep with cardiac failure. (1994)

The present study examines in detail the short-term cardiovascular actions of atrial natriuretic factor (ANF) in sheep with experimental low-output cardiac failure. Five conscious sheep, surgically implanted with a ventricular pacing wire, were paced at 220 beats/min for 14 days. Most clinical symptoms of congestive heart failure (CHF) were apparent after the 14 days, characterized by low cardiac output, high venous pressure, increased total peripheral resistance, increased plasma levels of ANF, noradrenaline, arginine vasopressin and renin, and marked fluid retention. On day 14 of pacing, intravenous infusion of ANF at 100 micrograms/h for 60 min restored cardiac output to prepacing values and reduced both total peripheral resistance and right atrial pressure. These effects were sustained throughout the infusion period. No change was seen in blood pressure, plasma renin, or noradrenaline levels. These hemodynamic changes, produced by short-term infusion of ANF, contrasted with those seen in normal sheep, where there was a fall in cardiac output with increased total peripheral resistance. These changes reflect a return toward normal of the left ventricular function curve. This is the first study to report that ANF improves cardiac function in conscious sheep with CHF, primarily by a vasodilator action to reduce cardiac preload, and suggests that ANF may be useful in treating the hemodynamic effects associated with cardiac failure.
The antioxidants α‐lipoic acid and N‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice (2003)

Oxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, alpha-lipoic acid (LA) and N-acetylcysteine (NAC), to reverse the cognitive deficits found in the SAMP8 mouse. By 12 months of age, this strain develops elevated levels of Abeta and severe deficits in learning and memory. We found that 12-month-old SAMP8 mice, in comparison with 4-month-old mice, had increased levels of protein carbonyls (an index of protein oxidation), increased TBARS (an index of lipid peroxidation) and a decrease in the weakly immobilized/strongly immobilized (W/S) ratio of the protein-specific spin label MAL-6 (an index of oxidation-induced conformational changes in synaptosomal membrane proteins). Chronic administration of either LA or NAC improved cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. These effects probably occurred directly within the brain, as NAC crossed the blood-brain barrier and accumulated in the brain. Furthermore, treatment of 12-month-old SAMP8 mice with LA reversed all three indexes of oxidative stress. These results support the hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants.
Theory and characteristics of holographic polymer dispersed liquid crystal transmission grating with scaffolding morphology (2012)

We have performed a detailed characterization of the optical properties of a holographic polymer dispersed liquid crystal (LC) transmission grating with polymer scaffolding morphology, which was fabricated with conventional high-functionality acrylate monomer under low curing intensity. Temporal evolution of the grating formation was investigated, and the amount of phase-separated LC was determined by birefringence investigation. A grating model combined with anisotropic coupled-wave theory yielded good agreement with experimental data without any fitting parameter. The results in this study demonstrate the non droplet scaffolding morphology grating is characterized by a high degree of phase separation (70%), high anisotropy, low scattering loss (<6%), and high diffraction efficiency (95%).
Eukaryotic genome size databases (2006)

Three independent databases of eukaryotic genome size information have been launched or re-released in updated form since 2005: the Plant DNA C-values Database (www.kew.org/genomesize/homepage.html), the Animal Genome Size Database (www.genomesize.com) and the Fungal Genome Size Database (www.zbi.ee/fungal-genomesize/). In total, these databases provide freely accessible genome size data for >10,000 species of eukaryotes assembled from more than 50 years' worth of literature. Such data are of significant importance to the genomics and broader scientific community as fundamental features of genome structure, for genomics-based comparative biodiversity studies, and as direct estimators of the cost of complete sequencing programs.
A Novel Protecting Group for Constructing Combinatorial Peptide Libraries (2001)

Abstract 3,4,5-Tris(octadecyloxy)benzyl alcohol, HO–Bzl(OC18)3, was prepared from gallic acid and stearyl bromide. Using conventional step-wise elongation, N,C-protected peptides, Fmoc–AAn–...–AA1–OBzl(OC18)3, were synthesized. The substituted benzyl esters were selectively cleaved by a treatment with 4 M hydrogen chloride in ethyl acetate to give Fmoc–AAn–...–AA1–OH and HO–Bzl(OC18)3. Thus, the substituted benzyl group is effective for the protection of C-terminal carboxyl groups in liquid-phase peptide synthesis. Because the substituted benzyl group has a moderately high molecular weight, Fmoc–AAn–...–AA1–OBzl(OC18)3 can be easily purified by size-exclusion chromatography; all protected peptides are eluted in the void fraction of a Sephadex LH-20 gel-filtration column. The combination of the carboxyl-protecting group Bzl(OC18)3 with simple purification by the gel-filtration gives a novel route for constructing combinatorial peptide libraries in the solution phase.
Protein‐mediated DNA transfer into liposomes (1998)

The transfer of a foreign genome into a bacterium by means of phage infection is a very efficient but poorly understood process. To analyse the mechanism of phage DNA transfer at a molecular level, we have reconstituted FhuA, the receptor for phage T5 in the outer membrane of Escherichia coli, into unilamellar vesicles made of natural phospholipids. Cryoelectron microscopy studies showed that the binding of the phage to FhuA triggered the transfer of its double-stranded DNA (121000 bp) into the proteoliposomes. DNA was entrapped within vesicles with a diameter ranging from 70 to 150 nm. The DNA appeared to be densely packed, but its presence did not alter the morphology of the liposomes, suggesting no DNA-lipid interactions. These liposomes represent an attractive model system for studying the mechanisms of DNA transport and condensation. They may also serve as alternative vehicles for the transfer of foreign genes into eukaryotic cells.
The low-temperature, high-magnetic-field critical current characteristics of Zr-added (Gd,Y)Ba2Cu3Oxsuperconducting tapes (2012)

Critical current performances of state-of-the-art Zr-added (Gd, Y)BaCuO tapes have been investigated over a temperature range of 20–77 K, in magnetic fields up to 9 T and over a wide angular range of magnetic field orientations. The peak in critical current that is commonly observed in the field orientation perpendicular to the tape in BaZrO3 (BZO) containing superconducting tapes is found to vanish at 30 K in magnetic fields at 1–9 T. While the critical current of 15% Zr-added tapes was about 40% lower than that of 7.5% Zr-added tapes at 77 K, the pinning force values of the former were found to be 18–23% higher than those of the latter in the temperature range of 20–40 K and in magnetic fields of 3–5 T. The results from this study emphasize the importance of optimization of coated conductor fabrication processes for optimum performance not just in low magnetic fields at 77 K but also at the operating conditions of low temperatures and high magnetic fields that are of interest, especially for rotating superconducting machinery applications.