gebhart/patrepeval huggingface dataset:
Analysis and design of a zero-voltage switched, three-phase PWM rectifier with power factor correction (2003)

A three-phase, single-stage, isolated PWM rectifier capable of power factor correction and low harmonic current distortion and at the same time realizing zero voltage switching for all power semiconductor devices is proposed. The circuit is thoroughly analyzed. Design equations and tradeoffs are provided. The performance of the circuit is demonstrated through the implementation of a 2 kW, 91 kHz, digital signal processor controlled prototype. The isolated DC output voltage is regulated at 50 V. The conversion efficiency is around 93%.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biomaterial-associated infection of gentamicin-loaded PMMA beads in orthopaedic revision surgery (2001)

In two-stage orthopaedic revision surgery, high local levels of antibiotics are achieved after removal of an infected prosthesis through temporary implantation of gentamicin-loaded beads. However, despite their antibiotic release, these beads act as a biomaterial surface to which bacteria preferentially adhere, grow and potentially develop antibiotic resistance. Gentamicin-loaded beads were retrieved from 20 patients with prosthesis-related infections. Excised tissue samples were taken for routine culture, while beads were analysed in an extensive laboratory procedure. Extensive culture procedures indicated the presence of bacteria on gentamicin-loaded beads in 18 of the 20 patients involved, while 12 of these 18 patients were considered free of infection by routine culture. Nineteen of 28 bacterial strains isolated were gentamicin resistant and cultures from three patients yielded highly gentamicin-resistant sub-populations. It is concluded that routine culture of excised tissues in orthopaedic revision surgery is inadequate to ascertain full eradication of infection, especially as infecting, antibiotic-resistant bacteria preferentially adhere to and grow on gentamicin-loaded beads. Extensive examination of the bead surfaces is proposed as a more reliable indication that infection has been eradicated.
Efficient Document Clustering via Online Nonnegative Matrix Factorizations (2011)

In recent years, Nonnegative Matrix Factorization (NMF) has received considerable interest from the data mining and information retrieval fields. NMF has been successfully applied in document clustering, image representation, and other domains. This study proposes an online NMF (ONMF) algorithm to efficiently handle very large-scale and/or streaming datasets. Unlike conventional NMF solutions which require the entire data matrix to reside in the memory, our ONMF algorithm proceeds with one data point or one chunk of data points at a time. Experiments with one-pass and multi-pass ONMF on real datasets are presented.
Partial characterization of an interleukin-1-like factor in human gingival crevicular fluid from patients with chronic inflammatory periodontal disease (1990)

A significant level of interleukin-1-(IL-1)-like activity was detected in gingival crevicular fluid obtained from sites in patients with chronic inflammatory periodontal disease, confirming a previous report of IL-1-like activity detected in human gingival crevicular fluid from patients with chronic inflammatory periodontitis (J. A. Charon, T. A. Luger, S. E. Mergenhagen, and J. J. Oppenheim, Infect. Immun. 38:1190-1195, 1982). In the present study, we sought to investigate whether this IL-1-like activity belonged to IL-1 alpha or IL-1 beta and to characterize some of the biochemical properties of this factor. Polyclonal antibodies against recombinant human IL-1 alpha or IL-1 beta (rIL-1 alpha or rIL-1 beta) have been used for serological comparison of the IL-1-like factor. IL-1-like activity was completely neutralized by anti-human rIL-1 alpha antiserum, but not by anti-human rIL-1 beta antiserum. On gel filtration with a high-pressure liquid chromatographic Superose 12 column, IL-1-like activity was separated into two peaks, one with a molecular weight of about 43,000 and the other with a molecular weight of less than 17,000. The majority of the IL-1-like factor with a low molecular weight in human gingival crevicular fluid migrated at a molecular weight of about 17,000 under the reducing conditions of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The specificity of the IL-1-like factor was further confirmed by an immunochemical method (Western blotting [immunoblotting]) by using anti-human rIL-1 alpha monoclonal antibodies. On isoelectric chromatography with a high-pressure liquid chromatographic Mono P column, the pI of this IL-1-like factor was between pH 4.9 and 5.2. These results suggest that the IL-1-like factor in human gingival crevicular fluid from diseased sites in patients with chronic inflammatory periodontitis consists predominantly of IL-1 alpha.
Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen (2006)

Infections caused by the obligate intracellular pathogen Chlamydia trachomatis have a marked impact on human health. C. trachomatis serovariants are the leading cause of bacterial sexually transmitted disease and infectious preventable blindness. Despite decades of effort, there is no practical vaccine against C. trachomatis diseases. Here we report that all C. trachomatis reference serotypes responsible for sexually transmitted disease and blinding trachoma synthesize a highly conserved surface-exposed antigen termed polymorphic membrane protein D (PmpD). We show that Ab specific to PmpD are neutralizing in vitro. We also present evidence that Ab against serovariable-neutralizing targets, such as the major outer membrane protein, block PmpD neutralization. This finding suggests that a decoy-like immune evasion strategy may be active in vivo whereby immunodominant type-specific surface antigens block the neutralizing ability of species-common PmpD Ab. Collectively, these results show that PmpD is a previously uncharacterized C. trachomatis species-common pan-neutralizing target. Moreover, a vaccine protocol using recombinant PmpD to elicit neutralizing Ab in the absence of immunodominant type-specific Ab might be highly efficacious and surpass the level of protection achieved through natural immunity.
Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics (2009)

The aim of this study was to determine whether mexiletine, a CYP1A2 inhibitor, altered the pharmacokinetics and pharmacodynamics of tizanidine. The pharmacokinetics of tizanidine were examined in an open-label study in 12 healthy participants after a single dose of tizanidine (2 mg) with and without mexiletine coadministration (50 mg, 3 times as a pretreatment for a day and 2 times on the study day). Compared with tizanidine alone, mexiletine coadministration increased the peak plasma concentration (1.8 +/- 0.8 vs 5.3 +/- 1.8 ng/mL), area under the curve (4.5 +/- 2.2 vs 15.4 +/- 6.5 ng x h/mL), and the half-life (1.3 +/- 0.2 vs 1.8 +/- 0.7 h) of tizanidine, respectively (P < .05). Reduction in systolic blood pressure (-10 +/- 8 vs -24 +/- 7 mm Hg) and diastolic blood pressure (-10 +/- 7 vs -18 +/- 8 mm Hg) after tizanidine administration was also significantly enhanced by coadministration of mexiletine (P < .01). Of the 15 patients treated with tizanidine and mexiletine, 4 suffered tizanidine-induced adverse effects such as drowsiness and dry mouth in the retrospective survey. Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms.
Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development? (1993)

Long-term bone marrow cultures mirror many aspects of in vivo mammalian hematopoiesis. Thus, these cultures have been used widely to analyze the complex interactions that regulate hematopoietic differentiation. Hematopoiesis in vivo and in vitro is dependent on stromal cells, a mixture of support cells. In the past years numerous clonal stromal cell lines derived from murine and human tissues have been isolated and characterized. The stromal cell lines have proved to be invaluable tools for the elucidation of the molecular and cellular signals that govern differentiation and self-renewal of hematopoietic cells. This review describes the salient features of arrow cultures with a focus on the isolation and characterization of stromal cell lines. We summarize how stromal cell lines have been crucial tools for the detection, isolation, and maintenance of rare pluripotent stem cells and B lineage cells. Intriguing questions about the nature of stromal cells, their requirements for growth and differentiation, and their histogenic origin remain areas for further investigation.
The Pharmacodynamic Effects of a Lower-Lipid Emulsion of Propofol: A Comparison with the Standard Propofol Emulsion (2004)

The pharmacodynamic profile of a lower-lipid containing emulsion of propofol (Ampofol) was compared with Diprivan when administered for induction and maintenance of general anesthesia. This preliminary study demonstrated that the two formulations of propofol were equivalent with respect to their induction and maintenance properties. However, Ampofol was associated with a more frequent incidence of pain on injection.
Silicon‐on‐lnsulator Devices for High Voltage and Power IC Applications (1994)

Silicon‐on‐insulator (SOI) technology based on wafer bonding promises to deliver significant performance advantages and cost reduction over the existing bulk silicon technologies used for making power integrated circuits. A review is presented of the fundamental considerations that arise in the study of SOI devices for high‐voltage applications. Significant device design parameters, such as the off‐state breakdown voltage, on‐state specific resistance, thermal dissipation, packing density, and manufacturability are discussed in the context of the applicable device physics and SOI material requirements. Several possible approaches for achieving high breakdown voltages in SOI devices are described. The advantages and limitations of each approach are discussed and illustrated with some recent results on experimental devices.
Molecular Chaperones Stimulate the Functional Expression of the Cocaine-sensitive Serotonin Transporter (1999)

The serotonin transporter (SERT) is an N-glycosylated integral membrane protein that is predicted to contain 12 transmembrane regions. SERT is the major binding site in the brain for antidepressant drugs, and it also binds amphetamines and cocaine. The ability of various molecular chaperones to interact with a tagged version of SERT (Myc-SERT) was investigated using the baculovirus expression system. Overexpression of Myc-SERT using the baculovirus system led to substantial quantities of inactive transporter, together with small amounts of fully active and, therefore, correctly folded molecules. The high levels of inactive Myc-SERT probably arose because folding was rate-limiting due, perhaps, to insufficient molecular chaperones. Therefore, Myc-SERT was co-expressed with the endoplasmic reticulum (ER) molecular chaperones calnexin, calreticulin and immunoglobulin heavy chain binding protein (BiP), and the foldase, ERp57. The expression of functional Myc-SERT, as determined by an inhibitor binding assay, was enhanced nearly 3-fold by co-expressing calnexin, and to a lesser degree on co-expression of calreticulin and BiP. Co-expression of ERp57 did not increase the functional expression of Myc-SERT. A physical interaction between Myc-SERT-calnexin and Myc-SERT-calreticulin was demonstrated by co-immunoprecipitation. These associations were inhibited in vivo by deoxynojirimycin, an inhibitor of N-glycan precusor trimming that is known to prevent the calnexin/calreticulin-N-glycan interaction. Functional expression of the unglycosylated SERT mutant, SERT-QQ, was also increased on co-expression of calnexin, suggesting that the interaction between calnexin and SERT is not entirely dictated by the N-glycan. SERT is the first member of the neurotransmitter transporter family whose folding has been shown to be assisted by the molecular chaperones calnexin, calreticulin, and BiP.
Stress‐Triggered Abortion: Inhibition of Protective Suppression and Promotion of Tumor Necrosis Factor‐α (TNF‐α) Release as a Mechanism Triggering Resorptions in Mice (1995)

These data suggest that stress may inhibit protective suppressor mechanisms and promote secretion of abortogenic cytokines such as TNF-alpha. Possible mechanisms are discussed.
Living Radical Polymerization by the RAFT Process – A Third Update (2012)

This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(=S)SR) by a mechanism of reversible addition-fragmentation chain transfer (RAFT) that was published in June 2005 (Aust. J. Chem.2005, 58, 379). The first update was published in November 2006 (Aust. J. Chem.2006, 59, 669) and the second in December 2009 (Aust. J. Chem.2009, 62, 1402). This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.
Serum Antibodies to Retinal Antigens in Lung Cancer and Sarcoidosis (2004)

Antibodies to RAs occur more frequently and in higher titers in lung cancer (especially SCLC) than in sarcoidosis or control sera. Although antibodies to retinal alpha-enolase, recoverin and other RAs are present mainly or exclusively in lung cancer sera, none of them seems to be a specific marker of a particular disease.
Forecasting Interactive Dynamics of Pedestrians with Fictitious Play (2016)

We develop predictive models of pedestrian dynamics by encoding the coupled nature of multi-pedestrian interaction using game theory, and deep learning-based visual analysis to estimate person-specific behavior parameters. Building predictive models for multi-pedestrian interactions however, is very challenging due to two reasons: (1) the dynamics of interaction are complex interdependent processes, where the predicted behavior of one pedestrian can affect the actions taken by others and (2) dynamics are variable depending on an individuals physical characteristics (e.g., an older person may walk slowly while the younger person may walk faster). To address these challenges, we (1) utilize concepts from game theory to model the interdependent decision making process of multiple pedestrians and (2) use visual classifiers to learn a mapping from pedestrian appearance to behavior parameters. We evaluate our proposed model on several public multiple pedestrian interaction video datasets. Results show that our strategic planning model explains human interactions 25% better when compared to state-of-the-art methods.
ALUMNOS DEL CCH, PRIMEROS EN LA OLIMPIADA DE TECNOLOGIA (1994)

LOS ALUMNOS DEL CCH, PLANTELES AZCAPOTZALCO: ANGELICA ROJAS VALDES, ALEJANDRO ARREGUIN CASTILLO Y LOURDES GONZALEZ MORALES, ACOMPANADOS POR SU ASESOR, PROFESOR GABRIEL GUERRA GOMEZ, Y ORIENTE: MINERVA HERNANDEZ VENEGAS, OFELIA VALDEZ VALDEZ Y MARIA DE JESUS PIEDRAS CABALLERO, OBTUVIERON EL PRIMER LUGAR DE SU ZONA Y PASE PARA COMPETIR A NIVEL NACIONAL, DURANTE LA OLIMPIADA DEL CONOCIMIENTO DE TECNOLOGIA APLICADA, REALIZADA EN ABRIL, ORGANIZADA POR LAS SECRETARIAS DE EDUCACION PUBLICA, Y DESARROLLO SOCIAL, ASI COMO POR LA ACADEMIA MEXICANA DE INGENIERIA Y EDUCACION SUPERIOR, CON EL FIN DE INICIAR A LOS ALUMNOS EN LA PLANEACION DE DISENOS UTILES A LA SOCIEDAD. LOS PROYECTOS GANADORES FUERON ELABORACION DE JAMON DE CONEJO, Y CONTROL Y CRECIMIENTO DE LA TILAPIA EN CONDICIONES DE LABORATORIO.
A coupled in vitro transcription‐translation system for the exclusive synthesis of polypeptides expressed from the T7 promoter (1991)

A coupled transcription-translation in vitro system has been developed in Escherichia coli specifically for the expression of genes under the exclusive control of the T7 promoter. This system consists of an E. coli crude extract (prepared from cells containing endogenous T7 RNA polymerase), rifampicin (an E. coli RNA polymerase inhibitor) and a labelled amino acid. When primed with a plasmid template encoding the target gene under exclusive control of the T7 promoter, this system has the capability to synthesize relatively large amounts of a unique, labelled polypeptide. This paper describes the characteristics and use of such a T7 RNA polymerase/T7-promoter specific in vitro system.
Hematopoietic origin of glomerular mesangial cells (2003)

It was recently reported that crude bone marrow cells have the ability to differentiate into glomerular mesangial cells. However, the exact nature of the engrafting cells in the bone marrow was not known. We tested the hypothesis that hematopoietic stem cells are capable of reconstituting the mesangial cells by transplanting a clonal population of cells derived from a single stem cell. We cultured Lin(-), Sca-1(+), c-kit(+), CD34(-) bone marrow cells from transgenic enhanced green fluorescent protein (EGFP) mice (C57BL/6-Ly-5.2 background) individually for 1 week in the presence of interleukin-11 and steel factor. We then transplanted viable clones individually into lethally irradiated C57BL/6-Ly-5.1 mice. Kidneys from 5 recipient mice showing high levels (60%-90%) of multilineage hematopoietic reconstitution were examined 2 to 6 months later, using differential interference contrast and epifluorescence microscopy. EGFP(+) cells with a morphology characteristic of mesangial cells were evident within the glomeruli. Transplantation of 100 noncultured Lin(-), Sca-1(+), c-kit(+), CD34(-) bone marrow cells also generated mesangial cells. Cultured EGFP(+) glomerular cells from recipient mice contracted in response to angiotensin II. EGFP(+) mesangial cells seen in male-to-male transplants revealed only one Y-chromosome. These data demonstrate that a single hematopoietic stem cell is capable of differentiating into glomerular mesangial cells and that the process does not involve cell fusion.
Thermal-Aware Task Scheduling for 3D Multicore Processors (2009)

A rising horizon in chip fabrication is the 3D integration technology. It stacks two or more dies vertically with a dense, high-speed interface to increase the device density and reduce the delay of interconnects significantly across the dies. However, a major challenge in 3D technology is the increased power density, which gives rise to the concern of heat dissipation within the processor. High temperatures trigger voltage and frequency throttlings in hardware, which degrade the chip performance. Moreover, high temperatures impair the processor's reliability and reduce its lifetime. To alleviate this problem, we propose in this paper an OS-level scheduling algorithm that performs thermal-aware task scheduling on a 3D chip. Our algorithm leverages the inherent thermal variations within and across different tasks, and schedules them to keep the chip temperature low. We observed that vertically adjacent dies have strong thermal correlations and the scheduler should consider them jointly. Compared with other intuitive algorithms such as a Random and a Round-Robin algorithm, our proposed algorithm brings lower peak temperature and average temperature on-chip. Moreover, it can remove, on average, 46 percent of thermal emergency time and result in 5.11 percent (4.78 percent) performance improvement over the base case on thermally homogeneous (heterogeneous) floorplans.
Identification of a Novel RING Finger Protein as a Coregulator in Steroid Receptor-Mediated Gene Transcription (1998)

Using the DNA-binding domain of androgen receptor (AR) as a bait in a yeast two-hybrid screening, we have identified a small nuclear RING finger protein, termed SNURF, that interacts with AR in a hormone-dependent fashion in both yeast and mammalian cells. Physical interaction between AR and SNURF was demonstrated by coimmunoprecipitation from cell extracts and by protein-protein affinity chromatography. Rat SNURF is a highly hydrophilic protein consisting of 194 amino acid residues and comprising a consensus C3HC4 zinc finger (RING) structure in the C-terminal region and a bipartite nuclear localization signal near the N terminus. Immunohistochemical experiments indicated that SNURF is a nuclear protein. SNURF mRNA is expressed in a variety of human and rat tissues. Overexpression of SNURF in cultured mammalian cells enhanced not only androgen, glucocorticoid, and progesterone receptor-dependent transactivation but also basal transcription from steroid-regulated promoters. Mutation of two of the potential Zn2+ coordinating cysteines to serines in the RING finger completely abolished the ability of SNURF to enhance basal transcription, whereas its ability to activate steroid receptor-dependent transcription was maintained, suggesting that there are separate domains in SNURF that mediate interactions with different regulatory factors. SNURF is capable of interacting in vitro with the TATA-binding protein, and the RING finger domain is needed for this interaction. Collectively, we have identified and characterized a ubiquitously expressed RING finger protein, SNURF, that may function as a bridging factor and regulate steroid receptor-dependent transcription by a mechanism different from those of previously identified coactivator or integrator proteins.
Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group. (1993)

This study confirms that plasma norepinephrine is an independent predictor of prognosis in patients with congestive heart failure. Hydralazine-isosorbide dinitrate treatment, unlike enalapril treatment, was associated with increased plasma norepinephrine concentration during the first year of follow-up. The enalapril group had a significantly lower mortality, and this survival benefit of enalapril as compared with hydralazine-isosorbide dinitrate was most evident among patients with the most marked neuroendocrine activation. Neuroendocrine activation is an important prognostic factor for patients with congestive heart failure and is an important determinant of the differential response to vasodilators.
Broadband and gain-flattened amplifier composedof a 1.55 µm-band and a 1.58 µm-band Er 3+ -doped fibre amplifierin a parallel configuration (1997)

The authors construct a broadband and gain-flattened Er3+-doped fibre amplifier (EDFA) with a flat amplification bandwidth of 54 nm for wavelength division multiplexed signals. This was achieved by employing a 1.58 µm-band EDFA and a 1.55 µm-band EDFA in a parallel configuration. Excellent flat amplification characteristics were obtained for 1530–1560 nm and 1576–1600 nm signal wavelength regions, with a gain non-uniformity of &lt;1.7 dB and a signal gain of 30 dB.
Single- and multi-wall carbon nanotube field-effect transistors (1998)

We fabricated field-effect transistors based on individual single- and multi-wall carbon nanotubes and analyzed their performance. Transport through the nanotubes is dominated by holes and, at room temperature, it appears to be diffusive rather than ballistic. By varying the gate voltage, we successfully modulated the conductance of a single-wall device by more than 5 orders of magnitude. Multi-wall nanotubes show typically no gate effect, but structural deformations—in our case a collapsed tube—can make them operate as field-effect transistors.