gebhart/patrepeval huggingface dataset:
Four Flavonoids and Three Other Constituents from Achillea biebersteinii (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFour Flavonoids and Three Other Constituents from Achillea biebersteiniiEnis Oskay and Akgül YesiladaCite this: J. Nat. Prod. 1984, 47, 4, 742Publication Date (Print):July 1, 1984Publication History Published online1 July 2004Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/np50034a041https://doi.org/10.1021/np50034a041research-articleACS PublicationsRequest reuse permissionsArticle Views185Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A kinetic study of antibody producing cells in the spleen of mice immunized intravenously with sheep erythrocytes. (1968)

The number of antibody producing cells, i.e. rosette forming cells (RFC) has been studied in the spleen of mice injected intravenously with a full immunizing dose of sheep RBC. The spleen of a non-immunized mouse contains a background of about 70,000 RFC (normal RFC), which do not appear to be the `target cells' for antigens of sheep RBC. Our findings suggest that the spleen of a mouse contains about 4000 `target cells' which initiate the immune response to sheep RBC. In the primary response, the rise of RFC is exponential for about 96 hours with a doubling time of 13 hours involving seven to eight consecutive doubling periods. The peak value of RFC is 1·6 × 10(6) per spleen. In the secondary response, the doubling time of RFC is 6–7 hours. The exponential rise lasts 72 hours and includes nine to eleven doubling periods leading to a peak of 3·5 × 10(6) RFC/spleen. Adjuvant in the primary response leaves the doubling time of RFC unaltered but prolongs the exponential rise until the 120th hour leading to a peak of 6·3 × 10(6) RFC/spleen after ten doubling periods. The effects of priming and adjuvant are not fully additive.
Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22 (2011)

CD22 is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family expressed on B cells that recognizes glycans of glycoproteins as ligands. Because siglecs exhibit restricted expression on one or a few leukocyte cell types, they have gained attention as attractive targets for cell-directed therapies. Several antibody-based therapies targeting CD22 (Siglec-2) are currently in clinical trials for the treatment of hairy cell leukemia and other B cell lymphomas. As an alternative to antibodies we have developed liposomal nanoparticles decorated with glycan ligands of CD22 that selectively target B cells. Because CD22 is an endocytic receptor, ligand-decorated liposomes are bound by CD22 and rapidly internalized by the cell. When loaded with a toxic cargo such as doxorubicin, they are efficacious in prolonging life in a Daudi B cell lymphoma model. These B cell targeted nanoparticles have been demonstrated to bind and kill malignant B cells from patients with hairy cell leukemia, marginal zone lymphoma and chronic lymphocytic leukemia. The results demonstrate the potential of using CD22 ligand-targeted liposomal nanoparticles as an alternative approach for the treatment of B cell malignancies.
Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: Evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion (1997)

The role of N-linked glycosylation and glycan trimming in the function of glycoproteins remains a central question in biology. Hepatitis B virus specifies three glycoproteins (L, M, and S) that are derived from alternate translation of the same ORF. All three glycoproteins contain a common N-glycosylation site in the S domain while M possesses an additional N-glycosylation site at its amino terminus. In the presence of N-butyl-deoxnojirimycin (an inhibitor of alpha-glucosidase) virions and the M protein are surprisingly retained. Preliminary evidence suggests that the retained M protein is hyperglucosylated and localized to lysosomal vesicles. In contrast, the S and L proteins are secreted, and their glycosylation state is unaffected by the presence of the inhibitor. Site-directed mutagenesis provides evidence that virion secretion requires the glycosylation sequon in the pre-S2 domain of M. This highlights the potential role of the M protein oligosaccharide as a therapeutic target.
Synthesis of N,N-Diethylbenzamides via a Nonclassical Mitsunobu Reaction (2013)

The use of the Mitsunobu reaction for the synthesis of N,N-diethylbenzamides affords ortho-, meta-, and para-substituted benzamides, containing both electron-donating and electron-withdrawing groups. While the preparation of numerous functional groups has been efficiently demonstrated employing the Mitsunobu reaction, our methodology represents the first application of the Mitsunobu reaction for the construction of benzamides using benzoic acid and amine starting materials. Moreover, this synthetic transformation is believed to proceed via a non-classical mechanism involving the existence of an acyloxyphosphonium ion.
The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge (2014)

The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against Salmonella was unclear. Here, we demonstrate that neutrophils, typically viewed as cellular targets of IL-1β, themselves activate the NLRC4 inflammasome during acute Salmonella infection and are a major cell compartment for IL-1β production during acute peritoneal challenge in vivo. Importantly, unlike macrophages, neutrophils do not undergo pyroptosis upon NLRC4 inflammasome activation. The resistance of neutrophils to pyroptotic death is unique among inflammasome-signaling cells so far described and allows neutrophils to sustain IL-1β production at a site of infection without compromising the crucial inflammasome-independent antimicrobial effector functions that would be lost if neutrophils rapidly lysed upon caspase-1 activation. Inflammasome pathway modification in neutrophils thus maximizes host proinflammatory and antimicrobial responses during pathogen challenge.
A Comparison of the Effectiveness of Oseltamivir for the Treatment of Influenza A and Influenza B: A Japanese Multicenter Study of the 2003-2004 and 2004-2005 Influenza Seasons (2006)

Oseltamivir is less effective for influenza B than for influenza A with regard to duration of fever and virus persistence, irrespective of patient age or the timing of administration of the first dose.
Role of Mono- and Biarticular Muscles in Explosive Movements (1984)

From 24 vertical jumps (eight subjects, three jumps each), calculations of forces, torques, and power per joint were combined with EMG data of eight leg muscles and with estimations of their contraction velocities. In the second part of the push-off, a high power output of 3000-4000 W was delivered in the ankle joints during plantar flexion. This is attributed to a sequential energy flow from hip to knee and ankle joints. Through coordinated actions of both the m. gluteus maximus and the m. rectus femoris as well as the m. vastus med., intermedius and lat. (mm. vasti) and the m. gastrocnemius, power delivered by the monoarticular extensors of the hip and knee joints was transported distally via the biarticular muscles to the ankle joints. During the high plantar flexion velocity at the end of the push-off, hip and knee joints showed high extension velocities resulting in relatively low contraction velocities for the biarticular muscles. As a consequence they could deliver high forces, which allowed them to transport energy in a proximodistal direction and allowed them to decelerate the angular velocities of the hip and knee joints without losses due to eccentric contractions. It is concluded that this power transport is essential in the execution of explosive movements.
Obsessive–compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG) (2013)

Two experiments examined probiotic pretreatment (Lactobacillus rhamnosus GG) on obsessive-compulsive disorder (OCD)-like behavior induction by RU 24969 in BALB/cJ house mice. In the first experiment, two groups were defined by their daily pretreatment by oral gavage of either (a) L. rhamnosus (1×10⁹ CFU/day) or (b) the saline vehicle. Both a 2- and 4-week probiotic pretreatment attenuated OCD-like behavior induction (increased perseverative open-field locomotion, stereotypic turning, and marble burying) relative to saline pretreatment. Experiment 2 re-examined the 2-week probiotic pretreatment while also comparing it to a 4-week fluoxetine pretreatment. Again, groups were defined by daily pretreatment of either (a) L. rhamnosus for 2 weeks, (b) the saline vehicle for 2 weeks, or (c) fluoxetine (10 mg/kg) for 4 weeks. Pretreatment by either L. rhamnosus or fluoxetine blocked the induction of OCD-like behavior compared with saline pretreatment. Thus the 2-week probiotic pretreatment was again effective. Although side effects of fluoxetine or L. rhamnosus on androgen-dependent behaviors could not be demonstrated, L. rhamnosus treatment appeared comparable to fluoxetine treatment in attenuating mouse OCD-like behaviors.
A DNA-activated protein kinase from HeLa cell nuclei. (1990)

A DNA-activated protein kinase (DNA-PK) was purified from nuclei of HeLa cells. Activity was associated with a single high-molecular-mass (approximately-300,000 Da) polypeptide when analyzed by gel filtration, denaturing polyacrylamide gel electrophoresis, and Western immunoblotting using a monoclonal antibody that also inhibits enzyme activity. Nuclear localization was indicated by subcellular fractionation and confirmed by immunofluorescence on whole cells. Double-stranded DNA stimulated phosphorylation of the 300-kDa polypeptide in purified preparations as well as phosphorylation of the exogenous substrates alpha-casein, simian virus 40 large T antigen, and the human heat shock protein hsp90. Autophosphorylation led to inactivation of the enzyme. The phosphorylation of casein was stimulated over 30-fold by DNA and was specific for serine and threonine residues. Bovine serum albumin and histone H1 were poor substrates for DNA-PK, and no phosphorylation of immunoglobulin G or histones other than H1 was observed. Supercoiled or heat-denatured DNA and synthetic double-stranded RNA or RNA-DNA copolymers did not stimulate casein phosphorylation by DNA-PK. Interaction of the enzyme with DNA in the absence of exogenous substrates was demonstrated by thermal inactivation and gel mobility shifts. These characteristics identify DNA-PK as distinct from other protein kinases described in the literature and suggest that activation by DNA is an important feature of the enzyme's in vivo function.
Raf Inhibitors as Therapeutic Agents Against Neurodegenerative Diseases (2010)

The active form of the serine/threonine kinase cRaf-1 is upregulated postmortem in the brains of Alzheimer's disease (AD) patients and in transgenic mouse models of AD pathology. The persistent activation of cRaf-1 can activate the proinflammatory factor NFkappaB and consequently, upregulate the expression of several of its downstream factors such as the amyloid precursor protein (APP), Cox-2 and iNOS. These factors have been found upregulated in numerous neurodegenerative conditions including AD, epilepsy, brain trauma, and psychological stress. The Raf kinase inhibitors, GW5074 and ZM336372, are neuroprotective against many different neurotoxic insults in vitro, including the Abeta peptide, glutamate and glutathione depletion. Recently, we have reported that the multi-kinase and potent Raf inhibitor sorafenib reversed memory impairment and reduced the expression of APP, Cox-2, and iNOS in the brain of the transgenic mouse model of AD, APPswe. Similar improvement of behavioral outcome was attained after acute treatment with GW5074 in a mouse model of Huntington's disease. Several Raf inhibitors have been developed to treat aggressive forms of cancer showing an upregulation of Raf kinases. These Raf inhibitors offer a great promise as therapeutic tools against neurological disorders. The negative and positive aspects of these inhibitors as anti-neurodegenerative agents are discussed.
Occurrence and levels of the phytoalexin phaseollin in relation to delimitation at sites of infection of Phaseolus vulgaris by Colletotrichum lindemuthianum (1973)

Sequential quantitative analyses of phaseollin associated with individual sites of infection by Colletotrichum lindemuthianum on etiolated hypocotyls of Phaseolus vulgaris provide further insight concerning the possible function of phaseollin in compatible and incompatible host response. When detected, phaseollin was localized in and (or) around individual infection sites; it was not detected in adjacent healthy tissue. Its occurrence was correlated with the time of appearance of visible, necrotic flecks at sites of incompatible response. It was not detected at visibly necrotic sites of compatible response until these became delimited in appearance, after which it occurred in large amounts. Delimitation at these sites occurred well after visible necrosis was first apparent. At high levels of infection, individual sites of compatible infection coalesced before delimitation, and in such instances phaseollin was virtually absent for the duration of the experiments. The levels of phaseollin occurring at individual infection sites indicate that it does not function as the primary determinant of interaction type, but is associated with delimitation at sites of both compatible and incompatible interaction. With respect to phaseollin production, the difference between these interactions was clearly one of time of occurrence, rather than amount produced.
A neurophysiological theory for the pain mechanism of tic douloureux (1977)

In attempting to understand the mechanism of pain production in tic douloureux, one must account for the myelination pathology seen in the primary afferent fibers, the cases where trigger is in a different division than the pain, the frequent lack of a fixed neurologic deficit, the effective trigger stimuli corresponding to large caliber axons which would not seem to involve the small axons usually associated with pain production, and similar puzzling features of the disease. We present a theory which satisfactorily predicts, or is consistent with, most known features of tic; it is based upon two mechanistic assumptions, both of which have strong experimental foundations in the literature. The first is the trigeminal dorsal root reflex, and the second is the creation of extra action potentials at sites of altered myelination.
Potassium Uptake Supporting Plant Growth in the Absence of AKT1 Channel Activity (1999)

A transferred-DNA insertion mutant of Arabidopsis that lacks AKT1 inward-rectifying K+ channel activity in root cells was obtained previously by a reverse-genetic strategy, enabling a dissection of the K+-uptake apparatus of the root into AKT1 and non-AKT1 components. Membrane potential measurements in root cells demonstrated that the AKT1 component of the wild-type K+ permeability was between 55 and 63% when external [K+] was between 10 and 1,000 microM, and NH4+ was absent. NH4+ specifically inhibited the non-AKT1 component, apparently by competing for K+ binding sites on the transporter(s). This inhibition by NH4+ had significant consequences for akt1 plants: K+ permeability, 86Rb+ fluxes into roots, seed germination, and seedling growth rate of the mutant were each similarly inhibited by NH4+. Wild-type plants were much more resistant to NH4+. Thus, AKT1 channels conduct the K+ influx necessary for the growth of Arabidopsis embryos and seedlings in conditions that block the non-AKT1 mechanism. In contrast to the effects of NH4+, Na+ and H+ significantly stimulated the non-AKT1 portion of the K+ permeability. Stimulation of akt1 growth rate by Na+, a predicted consequence of the previous result, was observed when external [K+] was 10 microM. Collectively, these results indicate that the AKT1 channel is an important component of the K+ uptake apparatus supporting growth, even in the "high-affinity" range of K+ concentrations. In the absence of AKT1 channel activity, an NH4+-sensitive, Na+/H+-stimulated mechanism can suffice.
Rapid Thrombelastography Delivers Real-Time Results That Predict Transfusion Within 1 Hour of Admission (2011)

Graphical r-TEG results are available within minutes, correlate with conventional coagulation test that are not as rapidly available, and are predictive of early transfusions of packed red blood cells, plasma, and platelets.
Oxygen consumption by human oocytes and blastocysts grown in vitro (1986)

Oxygen consumption by human oocytes and blastocysts was analysed using a sensitive micro-spectrophotometric technique. Oocytes were obtained from women undergoing laparotomy for sterilization or hysterectomy, and blastocysts were obtained as spare embryos from the local in-vitro fertilization programme. There was no significant difference between oocyte oxygen consumption on the day of isolation and after 1 day of culture, 0.53 +/- 0.08 (n = 9) and 0.35 +/- 0.06 (n = 5) nl/h oocyte, respectively. Blastocyst oxygen consumption was measured after a culture period of 5-8 days after in-vitro fertilization. Mean oxygen consumption by healthy looking blastocysts was 0.34 +/- 0.03 (n = 15) nl/h blastocyst, and there was no change in oxygen consumption with culture time. This level of respiration was lower than expected, both when compared with the oocytes and when compared with levels reported for blastocysts of other species.
Uplink frame structure of short TTI system (2017)

The study item on latency reduction techniques was considered with shorter TTI length along with reduced processing times. When TTI length is shortened, the allowed processing times should be reduced linearly to achieve optimal gains. This needs to rely on new channel design. Latency reduction techniques is important KPI. 5G requirement LTE-evo needs low latency to fulfil 5G requirements, User pane latency <;0.5ms end to end, reliability 99.999% in <; 1ms. There are many shorted TTI length, now days, it is discussed on symbol 2, 4, 7 length. In this paper, the frame structure supports the Legacy LTE system and low latency. UEs, NodeBs which is support the low latency system, it can support the legacy LTE system. Low latency system can support one way end to end latency 1ms.
Multimetal-MOF-derived transition metal alloy NPs embedded in an N-doped carbon matrix: highly active catalysts for hydrogenation reactions (2016)

We report a MOF-templated route to synthesize transition metal alloy NPs embedded in an N-doped carbon matrix. The alloy-based catalysts exhibited excellent catalytic performance and widespread substrate applicability for the transfer hydrogenation of nitriles.
The metabolism of acetate in the colourless alga, Prototheca zopfii (1964)

Research Article| March 01 1964 The metabolism of acetate in the colourless alga, Prototheca zopfii AG Callely; AG Callely Search for other works by this author on: This Site PubMed Google Scholar D Lloyd D Lloyd Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1964) 90 (3): 483–489. https://doi.org/10.1042/bj0900483 Connected Content A correction has been published: The metabolism of acetate in the colourless alga, Prototheca zopfii Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation AG Callely, D Lloyd; The metabolism of acetate in the colourless alga, Prototheca zopfii. Biochem J 1 March 1964; 90 (3): 483–489. doi: https://doi.org/10.1042/bj0900483 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1964 The Biochemical Society1964 Article PDF first page preview Close Modal You do not currently have access to this content.
Computer control of bakers' yeast production (1979)

Abstract The Biotechnology and Bioengineering study presented here was undertaken to demonstrate the usefulness of computer control for the production of yeast from molasses. A flexible control system was developed by using an on‐line computer for the monitoring of cell mass and employing anticipatory control to maintain the maximum productivity. Process disturbances were minimized by employing a multivariable feedback control system to prevent ethanol formation. The control strategy acted to keep overall conversion yield at its maximum level, about 0.5 g cell/ g sugar, while maintaining high volumetric productivity between 3 and 5 g/liter‐hr. Results are presented to show the effectiveness of simultaneous anticipatory and feedback contol in overcoming problems of oxygen starvation, molasses quality, and variable inoculum size.
Immunity of children to diphtheria, tetanus, and poliomyelitis. (1979)

A survey of titres of diphtheria and tetanus antitoxins and of antibodies to polioviruses in the sera of 291 schoolchildren aged 15, 11, and 7 years showed that high immunisation rates can evoke protective concentrations of tetanus antitoxin in 98% of children and protective levels of the antibodies to diphtheria and all three types of poliomyelitis in 85% of children. Reinforcing immunisation at school entry appeared to be necessary to maintain adequate titres of diphtheria antitoxin in children up to 15 years of age, not essential to maintain adequate titres of tetanus antitoxin, and to have little effect on the titres of antibodies to poliomyelitis.
NBS1 Is a Prostate Cancer Susceptibility Gene (2004)

To evaluate whether an inactivating mutation in the gene for the Nijmegen breakage syndrome (NBS1) plays a role in the etiology of prostate cancer, we compared the prevalence of the 657del5 NBS1 founder allele in 56 patients with familial prostate cancer, 305 patients with nonfamilial prostate cancer, and 1500 control subjects from Poland. Loss of heterozygosity analysis also was performed on DNA samples isolated from 17 microdissected prostate cancers, including 8 from carriers of the 657del5 mutation. The NBS1 founder mutation was present in 5 of 56 (9%) patients with familial prostate cancer (odds ratio, 16; P < 0.0001), 7 of 305 (2.2%) patients with nonfamilial prostate cancer (odds ratio, 3.9; P = 0.01), and 9 of 1500 control subjects (0.6%). The wild-type NBS1 allele was lost in seven of eight prostate tumors from carriers of the 657del5 allele, but loss of heterozygosity was seen in only one of nine tumors from noncarriers (P = 0.003). These findings suggest that heterozygous carriers of the NBS1 founder mutation exhibit increased susceptibility to prostate cancer and that the cancers that develop in the prostates of carriers are functionally homozygous for the mutation.