gebhart/patrepeval huggingface dataset:
A Synthetic Lectin for β‐Glucosyl (2009)

Evolving tastes: Addition of alkoxy groups (green; see picture) to macrotricyclic carbohydrate receptors yields improved affinities and new selectivities. Notably, the propoxy-substituted receptor shows a strong preference for β-glucosyl. Glucose is bound both in water and reconstituted blood plasma, which holds promise for applications in blood glucose monitoring. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Growth of Transparent nc-InGaO[sub 3](ZnO)[sub 2] Thin Films with Indium mol Ratios Using Solution Process (2008)

The effect of indium mol ratio on nanocrystalline (nc)- thin films prepared by solution was investigated with structural properties. The size of nanocrystallines tended to increase up to with an optimized indium mol ratio after second postannealing at for with three cycles. The shape of the nanocrystallines and their growth were determined by the indium mol ratio. The main (008) growth direction, which had a columnar structure, could be retarded by a high indium mol ratio, which could generate the (100) direction growth. After postannealing, the films had with less oxygen deficiency and main stoichometric oxygen bound with metal (In, Ga, and Zn). The growth of nanocrystallines during the second postannealing from small grains with random orientation to large grains with well-aligned orientation could be explained by a self-solid phase reaction with decomposition and combination of precursor without any additional epitaxial layer. It implied that the crystallinity of thin films was strongly dependent on process parameters such as temperature and component mol ratio.
Resveratrol Inhibits Cyclooxygenase‐2 Transcription in Human Mammary Epithelial Cells (1999)

A large body of evidence suggests that inhibiting cyclooxygenase-2 (COX-2), the inducible form of COX, will be an important strategy for preventing cancer. In this study, we investigated whether resveratrol, a chemopreventive agent found in grapes, could suppress phorbol ester (PMA)-mediated induction of COX-2 in human mammary and oral epithelial cells. Treatment of cells with PMA induced COX-2 mRNA, COX-2 protein, and prostaglandin synthesis. These effects were inhibited by resveratrol. Nuclear runoffs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by resveratrol. Resveratrol inhibited PMA-mediated activation of protein kinase C and the induction of COX-2 promoter activity by c-Jun. Phorbol ester-mediated induction of AP-1 activity was blocked by resveratrol. These data are likely to be important for understanding the anticancer and anti-inflammatory properties of resveratrol.
Development of a new pyrolyzer for thermal desorption and/or pyrolysis gas chromatography of polymeric materials (1991)

Abstract A new vertical microfurnace‐type pyrolyzer for thermal desorption and/or pyrolysis‐gas chromatography has been developed. The pyrolyzer consists of two independent temperature‐controlled ovens. Initially, in the desorption process, a sample cup containing the polymeric sample of interest is inserted into an oven at 300°C; the sample is then re‐positioned at the upper part of the pyrolyzer where the temperature is maintained at room temperature. The resulting vaporized components such as residual solvents and additives give a desorption chromatogram. The relative peak intensities of desorbed plasticizers in acrylonitrile butadiene‐rubber gave a relative standard deviation ( RSD ) of less than 2%. Subsequently, pyrolysis of the remaining polymer is conducted by dropping the sample cup into the second, pyrolyzing, oven at 55°C; at this stage the pyrogram is recorded. The resulting two chromatograms of desorbed components and pyrolysis products make it easier to characterize the polymer formulation than the complicated pyrogram obtained by an ordinary, single‐step pyrolysis.
Impact of Family Stability on Children's Delinquency: An Implication for Family Preservation (2004)

ABSTRACT Employing for analysis a set of secondary data from the National Longitudinal Survey of Youth, the present study sought signs of theoretical support for this emphasis on family preservation. Specifically, the research examined the effects on childhood delinquency of the following variables: family stability; parenting style; parental supervision; and structural factors. Binomial logistic regression conducted with the data showed that children's likelihood of becoming delinquent drops noticeably in the following circumstances: they are female; they do not live in poverty; the mother is older or is African-American; they receive stringent parental supervision; and/or they spend many years in residence with biological parents and/or step-parents. Some implications for family preservation efforts are suggested by the study results.
Interaction with Groups of Autonomous Characters (2000)

This paper presents a methodology for constructing large groups of autonomous characters which respond in real time to the user&amp;apos;s interaction, as well as to each other and their environment. The characters are based on steering controllers under the direction of a simple mental model which mediates between several conflicting behavioral goals. The characters are represented graphically by 3d models with a library of animated motions which are choreographed by the behavioral controllers.
A PDA-Kalman Approach to Multiuser Detection in (2002)

Abstract— The Probabilistic Data Association (PDA) method formultiuser detection in synchronous code-division multiple-access(CDMA) communication channels is extended to asynchronousCDMA, where a Kalman filter or smoother is employed to trackthe correlated noise arising from the outputs of a decorrelator. Theestimates from the tracker, coupled with an iterative PDA, resultin impressively low bit error rates. Computer simulations showthat the new scheme significantly outperforms the best decisionfeedback detector. The algorithm has ( 3 ) complexity per timeframe, where is the number of users.Index Terms— Code-division multiple access, filtering, multiuserdetection, probabilistic data association. I. I NTRODUCTION T HE exponential computational complexity of the optimalmaximum-likelihood (ML) [1] multiuser detector forasynchronous code-division multiple-access (CDMA) com-munication channels has motivated research into suboptimalalgorithms that yield low bit error rates and that ensure poly-nomial computational costs. Examples of these include thedecorrelator [1] and the decision feedback (DF) detector [2],[4]. While these detectors provide bit error rates that are lowerthan the conventional matched-filter detector, there is still alarge performance gap between these detectors and the optimalML detector.In this letter, a new multiuser detection scheme for asyn-chronous CDMA channels is introduced. The detection schemeuses the Probabilistic Data Association (PDA) method for mul-tiuser detection in synchronous CDMA [3] in conjunction witha Kalman technique for tracking the correlated noise arisingfrom the outputs of a decorrelator. Simulation results show thatthe new detection scheme significantly outperforms the DF de-tector. We also remark that since the PDA and Kalman algo-rithms are both in complexity [3], [5], the new algo-rithm, which is a serial combination of the two (see Fig. 1), alsopossesses complexity per time frame, where is thenumber of users. (In the new asynchronous algorithm, PDA typ-ically converges in three iterations or less; this is similar to syn-chronous PDA in [3].)
A Centrifugal Microfluidic Platform That Separates Whole Blood Samples into Multiple Removable Fractions Due to Several Discrete but Continuous Density Gradient Sections (2016)

We present a miniaturized centrifugal platform that uses density centrifugation for separation and analysis of biological components in small volume samples (~5 μL). We demonstrate the ability to enrich leukocytes for on-disk visualization via microscopy, as well as recovery of viable cells from each of the gradient partitions. In addition, we simplified the traditional Modified Wright-Giemsa staining by decreasing the time, volume, and expertise involved in the procedure. From a whole blood sample, we were able to extract 95.15% of leukocytes while excluding 99.8% of red blood cells. This platform has great potential in both medical diagnostics and research applications as it offers a simpler, automated, and inexpensive method for biological sample separation, analysis, and downstream culturing.
Preservation of humidity and heat of respiratory gases in patients with a minute ventilation greater than 10 L/min (1994)

In patients with a minute ventilation of > 10 L/min (> 10.5 to 16.0 L/min), the Humid-Vent Filter had a temperature and humidification output close to the reference system (the Bennett Cascade 2 Humidifier). The Pall Ultipor Filter had a significantly lower temperature and humidification output in these patients.
Quantification of Tumor-Specific T Lymphocytes With the ELISPOT Assay (2000)

The characterization of tumor-associated antigens and of human leukocyte antigen (HLA) class I molecule-binding peptide epitopes derived from these antigens has prompted the initiation of various vaccination trials aimed at inducing tumor-specific CD8+ T cells in persons with cancer. Sensitive and easy-to-perform T-cell assays that assess the frequency of tumor-reactive T cells are crucial for the evaluation and further development of vaccination approaches. This review focuses on a novel ELISPOT technique that allows quantification of tumor-specific T lymphocytes from peripheral blood by detecting antigen-induced cytokine secretion. Various ELISPOT methods using different antigen-presenting cells and different cytokines as read-out are described. T-cell analyses performed using the standard chromium release assay and the ELISPOT assay are also compared. Results from various clinical trials, including peptide and whole tumor cell vaccination and cytokine treatment, are now available and show the suitability of the ELISPOT assay for monitoring T-cell responses. To establish a basis for standardization and to further improve this technique, the first comparative quality assurance studies analyzing T-cell frequencies in different laboratories with the ELISPOT assay are being performed.
Demonstrator to show the effects of negative stiffness on the natural frequency of a simple oscillator (2008)

This article describes a demonstrator to show the effects of negative stiffness on the free vibration of a simple oscillator. The test rig consists of a horizontal beam that is hinged at one end and is supported by two coil springs to form a single-degree-of-freedom system. Additional correction springs, which provide negative stiffness, can be attached to lower the natural frequency of the system. The effect of the change in natural frequency can be easily seen visually, and it is shown that for one of the configurations of correction springs, the natural frequency can be reduced by a factor of about 4.
Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli (1986)

The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene encoding the pilus structural subunit. Using mixed infections of the parental and mutant strains in an ascending rat cystitis model, we found that type 1-piliated mutants that lacked the receptor-binding function were as ineffective in bladder colonization as were mutants lacking the entire organelle.
Spatial and Temporal Gene Expression Patterns Occur during Corm Development (1992)

Luiz A. B. de Castro, Mauro Carneiro, Damares de C. M. Neshich, Genaro R. de Paiva, Spatial and Temporal Gene Expression Patterns Occur during Corm Development, The Plant Cell, Vol. 4, No. 12 (Dec., 1992), pp. 1549-1559
Inhibition of guinea-pig complement by derivatives of benzamidine. I. Effect of p-nitrophenylureido derivative of m-(m-phenoxypropoxy)benzamidine on guinea-pig complement component haemolytic activity. (1974)

Derivatives of benzamidine have been shown to be potent inhibitors of whole guinea-pig complement. Among these compounds the m-[m-(p-nitrophenylureido) phenoxypropoxy] benzamidine (NPUPPB) was the most potent complement inhibitor synthesized. NPUPPB blocked the addition of C1 to EAC4. It had no effect on the stability of EAC4 or the decay rate of EAC42. It also blocked the addition of C2 to EAC14. No effect of the inhibitor was found when C3 was added to EAC142. A profound inhibition occurred when either C[unk]567 was added to EAC1423 or when C5 was added to EAC1423. A slight though possibly insignificant effect occurred when C6 or C7 were added to EAC4235 and EAC42356. No effect occurred when C8 and C9 were added to the heat-stable intermediate EAC43567. NPUPPB is a potent though poorly soluble competitive inhibitor of complement activity.
Correction in trans for Fabry disease: expression, secretion and uptake of alpha-galactosidase A in patient-derived cells driven by a high-titer recombinant retroviral vector. (1996)

Fabry disease is an X-linked metabolic disorder due to a deficiency of alpha-galactosidase A (alpha-gal A; EC 3.2.1.22). Patients accumulate glycosphingolipids with terminal alpha-galactosyl residues that come from intracellular synthesis, circulating metabolites, or from the biodegradation Of senescent cells. Patients eventually succumb to renal, cardio-, or cerebrovascular disease. No specific therapy exists. One possible approach to ameliorating this disorder is to target corrective gene transfer therapy to circulating hematopoietic cells. Toward this end, an amphotropic virus-producer cell line has been developed that produces a high titer (>10(6) i.p. per ml) recombinant retrovirus constructed to transduce and correct target cells. Virus-producer cells also demonstrate expression of large amounts of both intracellular and secreted alpha-gal A. To examine the utility of this therapeutic vector, skin fibroblasts from Fabry patients were corrected for the metabolic defect by infection with this recombinant virus and secreted enzyme was observed. Furthermore, the secreted enzyme was found to be taken up by uncorrected cells in a mannose-6-phosphate receptor-dependent manner. In related experiments, immortalized B cell lines from Fabry patients, created as a hematologic delivery test system, were transduced. As with the fibroblasts, transduced patient B cell lines demonstrated both endogenous enzyme correction and a small amount of secretion together with uptake by uncorrected cells. These studies demonstrate that endogenous metabolic correction in transduced cells, combined with secretion, may provide a continuous source of corrective material in trans to unmodified patient bystander cells (metabolic cooperativity).
Method for sequential staining of GTL‐banded metaphases with fluorescent‐labeled chromosome‐specific paint probes (1993)

We describe a method for use of fluorescent-labeled whole chromosome-specific paint probes on GTL-banded metaphases to utilize the combined potential of these techniques for defining chromosome abnormalities. The efficacy of this method was tested on 6 cases involving different chromosome abnormalities and various tissues, including blood, amniotic fluid, skin fibroblasts, and bone marrow.
Aspirin, age, and proximity to lymphoid nodules influence cell proliferation parameters in rat colonic crypts (1995)

Recent epidemiological studies have demonstrated a correlation between regular aspirin (acetylsalicylic acid) use and decrease risk for the development of fatal colorectal cancer. An increase in the size of the cell proliferation compartment in colorectal crypts has been correlated with an increased risk for the development of colon cancer in animals and in humans. To determine if acetylsalicylic acid acts to decrease the size of the cell proliferation compartment, young (3 month) and old (22 month) rats were treated intragastrically with: 1 the vehicle for acetylsalicylic acid delivery (0.25% wt/vol carboxymetylcellulose in 0.15 N (HCl), 2 a single dose of acetylsalicylic acid (100 mg/kg), or 3 acetylsalicylic acid (30 mg/kg) given daily for 30 days. One day after the last treatment, colons were resected, fixed, sectioned and mounted on slides for immunohistochemical staining with a monoclonal antibody to proliferating cell nuclear antigen to assess cell proliferation parameters in the colonic crypts. The results were subjected to three way analysis of variance to assess the effects of: 1 rat age, 2 acute or chronic acetylsalicylic acid treatment, and 3 location of crypts over and away from aggregates of lymphoid nodules on the crypt proliferative parameters. Results demonstrated that: 1 acetylsalicylic acid treatment caused on overall decrease in the proliferative zone height, as measured in number of cells in the crypt column, 2 that crypts located over aggregates of lymphoid nodules had significantly higher proliferative activity than crypts located away from aggregates of lymphoid nodules, and 3 after chronic acetylsalicylic acid treatment there was a greater suppression of proliferative zone height in the crypts of old rats than in the crypts of young rats. In conclusion, acute and chronic intragastric delivery of acetylsalicylic acid caused an overall downward shift in the cell proliferation compartment of colonic crypts of young and of old rats. Whether or not acetylsalicylic acid administration will cause the same proliferative zone height response in carcinogen-treated rats is not yet established.
GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules (1997)

The molecular mechanisms underlying the organization of ion channels and signaling molecules at the synaptic junction are largely unknown. Recently, members of the PSD-95/SAP90 family of synaptic MAGUK (membrane-associated guanylate kinase) proteins have been shown to interact, via their NH2-terminal PDZ domains, with certain ion channels (NMDA receptors and K+ channels), thereby promoting the clustering of these proteins. Although the function of the NH2-terminal PDZ domains is relatively well characterized, the function of the Src homology 3 (SH3) domain and the guanylate kinase-like (GK) domain in the COOH-terminal half of PSD-95 has remained obscure. We now report the isolation of a novel synaptic protein, termed GKAP for guanylate kinase-associated protein, that binds directly to the GK domain of the four known members of the mammalian PSD-95 family. GKAP shows a unique domain structure and appears to be a major constituent of the postsynaptic density. GKAP colocalizes and coimmunoprecipitates with PSD-95 in vivo, and coclusters with PSD-95 and K+ channels/NMDA receptors in heterologous cells. Given their apparent lack of guanylate kinase enzymatic activity, the fact that the GK domain can act as a site for protein-protein interaction has implications for the function of diverse GK-containing proteins (such as p55, ZO-1, and LIN-2/CASK).
The effect of shadow quality on the perception of spatial relationships in computer generated imagery (1992)

Article The effect of shadow quality on the perception of spatial relationships in computer generated imagery Share on Author: Leonard Wanger View Profile Authors Info & Claims I3D '92: Proceedings of the 1992 symposium on Interactive 3D graphicsJune 1992 Pages 39–42https://doi.org/10.1145/147156.147161Online:01 June 1992Publication History 50citation1,010DownloadsMetricsTotal Citations50Total Downloads1,010Last 12 Months51Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Plasma Amyloid-β as a Biomarker in Alzheimer's Disease: The AIBL Study of Aging (2010)

Amyloid-beta (Abeta) plays a central role in the pathogenesis of Alzheimer's disease (AD) and has been postulated as a potential biomarker for AD. However, there is a lack of consensus as to its suitability as an AD biomarker. The objective of this study was to determine the significance of plasma Abeta as an AD biomarker and its relationship with Abeta load and to determine the effect of different assay methods on the interpretation of Abeta levels. Plasma Abeta1-40, Abeta1-42, and N-terminal cleaved fragments were measured using both a commercial multiplex assay and a well-documented ELISA in 1032 individuals drawn from the well-characterized Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Further, Abeta levels were compared to Abeta load derived from positron-emission tomography (PET) with the Pittsburgh compound B (PiB). Lower Abeta1-42 and Abeta1-42/1-40 ratio were observed in patients with AD and inversely correlated with PiB-PET derived Abeta load. However, assay methodology significantly impacted the interpretation of data. The cross-sectional analysis of plasma Abeta isoforms suggests that they may not be sufficient per se to diagnose AD. The value of their measurement in prognosis and monitoring of AD interventions needs further study, in addition to future longitudinal comparisons together with other predictors, which will determine whether plasma Abeta has diagnostic value in a panel of biomarkers.
Fitts' Law as a Research and Design Tool in Human-Computer Interaction (1992)

According to Fitts' law, human movement can be modeled by analogy to the transmission of information. Fitts' popular model has been widely adopted in numerous research areas, including kinematics, human factors, and (recently) human-computer interaction (HCI). The present study provides a historical and theoretical context for the model, including an analysis of problems that have emerged through the systematic deviation of observations from predictions. Refinements to the model are described, including a formulation for the index of task difficulty that is claimed to be more theoretically sound than Fitts' original formulation. The model's utility in predicting the time to position a cursor and select a target is explored through a review of six Fitts' law studies employing devices such as the mouse, trackball, joystick, touchpad, helmet-mounted sight, and eye tracker. An analysis of the performance measures reveals tremendous inconsistencies, making across-study comparisons difficult. Sources of experimental variation are identified to reconcile these differences.