gebhart/patrepeval huggingface dataset:
Laser irradiation inhibition of open gingival embrasure space after orthodontic treatment (2002)

The purpose of this study was to investigate the inhibitory effect of low-energy laser irradiation on an incidence of open gingival embrasure space after orthodontic treatment. The patient was a 20-year, 7-month-old Japanese female with an Angle Class I malocclusion and crowding in the mandible. Treatment consisted of extraction of maxillary and mandibular first premolars and use of the Edgewise technique. A Ga-Al-As diode laser was used to irradiate an area of 0.5 cm2 at the labial and lingual gingival papilla between the canines. The time of exposure was 6 minutes for 3 days, carried out between the relevelling and en masse stages of movement. The total energy corresponding to 6 minutes of exposure varied from 1.90 J/cm2. There was no further evidence of open gingival embrasure space, except at the mandibular central incisor. Further: an improvement in the gingival inflammation caused by a periodontal disease was observed, and periodontal pocket depth was maintained. These results suggest that low-energy laser irradiation may inhibit the incidence of open gingival embrasure space after orthodontic treatment.
Novel Triamcinolone Acetonide-Loaded Liposomal Topical Formulation Improves Contrast Sensitivity Outcome After Femtosecond Laser-Assisted Cataract Surgery (2019)

<b><i>Purpose:</i></b> To assess visual results, macular modifications, and the incidence of clinically significant macular edema (CSME) in patients using a topical triamcinolone acetonide-loaded liposomal formulation (TA-LF) after femtosecond laser-assisted cataract surgery (FLACS). <b><i>Methods:</i></b> Fifty-six eyes after FLACS were selected. Twenty-eight eyes in the combined therapy group (P + N) were treated with prednisolone 1% and nepafenac 0.1% for 21 days postoperatively, whereas 28 eyes in the TA-LF group received a liposomal formulation containing 2 mg/mL of TA (0.2%) for the same period of time. Follow-up visits at 1 day, 6 weeks, and 12 weeks after surgery consisted of visual acuity, contrast sensitivity (CS), central foveal thickness (CFT), total macular volume (TMV) measurements, and the detection of CSME. <b><i>Results:</i></b> CS improved in the TA-LF group (basal value: 1.087 ± 0.339 vs. 1.276 ± 0.147 at week 12, <i>P</i> = 0.0346), whereas in the P + N group, CS was not different from the baseline (basal value: 1.130 ± 0.331 vs. 1.274 ± 0.133 at week 12, <i>P</i> = 0.1276). There were similar increases in postoperative CFT and TMV in both groups. CFT and TMV significantly correlate with CS only in the TA-LF group. The <i>r<sup>2</sup></i> for CFT and CS was 0.1963 (<i>P</i> = 0.0206), whereas the <i>r<sup>2</sup></i> for TMV and CS was 0.3615 (<i>P</i> = 0.0007) at 12 weeks. No difference was observed in the incidence of CSME between the groups. <b><i>Conclusion:</i></b> TA-LF is associated with better CS outcomes compared to combined therapy after FLACS.
Flexible Polymer‐Embedded Si Wire Arrays (2008)

Arrays of Si rods are embedded in PDMS and removed from the rigid growth substrate, resulting in a composite material that merges the benefits of single-crystalline silicon with the flexibility of a polymer. With this technique, solar cell absorber materials with the potential to achieve high efficiency can be prepared by high-temperature processing and transformed into a flexible, processable form.
Correction: Comparison of O-Antigen Gene Clusters of All O-Serogroups of Escherichia coli and Proposal for Adopting a New Nomenclature for O-Typing (2016)

[This corrects the article DOI: 10.1371/journal.pone.0147434.].
The contribution of constant region domains to the binding of murine IgM to Fc mu receptors on T cells. (1988)

IgM hybridoma constant region domain deletional mutants were used to investigate the domain requirements for binding of murine IgM to Fc mu receptors (Fc mu R) on normal murine T lymphocytes. Parental Sp 6:18 (mu, kappa; anti-trinitrophenyl) and its mutant proteins or their trinitrophenyl-antigen immune complexes were tested for their ability to inhibit the binding of pentameric IgM to Fc mu R on T lymphocytes. Inhibition was observed with ligands containing multiple copies of the third constant region domain. Inhibition did not occur with ligands missing the third constant region domain. In addition, a battery of rat monoclonal antibodies specific for individual murine IgM constant region domains was tested for the ability to inhibit the binding of pentameric murine IgM to Fc mu R on normal murine T lymphocytes. Total inhibition was observed with the antibodies directed to different epitopes located in C mu 3, but significant inhibition was not observed with antibodies directed to C mu 1, C mu 2, or C mu 4. Studies with domain deletional mutants and anti-domain antibodies have independently provided strong evidence that the C mu 3 domain plays a major role in the binding of IgM to Fc mu R on T lymphocytes and that C mu 1, C mu 2, and C mu 4 are not essential for binding. These studies have also provided evidence that valency and avidity influence the binding of IgM to T lymphocytes that express Fc mu R.
Learning to be a depth camera for close-range human capture and interaction (2014)

We present a machine learning technique for estimating absolute, per-pixel depth using any conventional monocular 2D camera, with minor hardware modifications. Our approach targets close-range human capture and interaction where dense 3D estimation of hands and faces is desired. We use hybrid classification-regression forests to learn how to map from near infrared intensity images to absolute , metric depth in real-time. We demonstrate a variety of human-computer interaction and capture scenarios. Experiments show an accuracy that outperforms a conventional light fall-off baseline, and is comparable to high-quality consumer depth cameras, but with a dramatically reduced cost, power consumption, and form-factor.
Isoprostanes: Free Radical–Generated Prostaglandins With Constrictor Effects on Cerebral Arterioles (1997)

Isoprostanes are potent constrictors of cerebral arterioles and appear to act at a receptor that is similar to the thromboxane A2/prostaglandin H2 receptor. Isoprostanes may play a role in the reduction of cerebral blood flow that occurs after brain injury and subsequent oxygen radical production.
Multi-scale recognition with DAG-CNNs (2015)

We explore multi-scale convolutional neural nets (CNNs) for image classification. Contemporary approaches extract features from a single output layer. By extracting features from multiple layers, one can simultaneously reason about high, mid, and low-level features during classification. The resulting multi-scale architecture can itself be seen as a feed-forward model that is structured as a directed acyclic graph (DAG-CNNs). We use DAG-CNNs to learn a set of multiscale features that can be effectively shared between coarse and fine-grained classification tasks. While fine-tuning such models helps performance, we show that even "off-the-self" multiscale features perform quite well. We present extensive analysis and demonstrate state-of-the-art classification performance on three standard scene benchmarks (SUN397, MIT67, and Scene15). In terms of the heavily benchmarked MIT67 and Scene15 datasets, our results reduce the lowest previously-reported error by 23.9% and 9.5%, respectively.
634. Hydroxy-quinoxalines and -phenazines, and experiments on the preparation of hydroxyquinoxaline di-N-oxides (1949)

F. E. King, N. G. Clark and P. M. H. Davis, J. Chem. Soc., 1949, 3012 DOI: 10.1039/JR9490003012
Perivascular Multipotent Progenitor Cells in Human Organs (2009)

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-Rbeta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.
A New Integration Method for an Electric Vehicle Wireless Charging System Using LCC Compensation Topology: Analysis and Design (2016)

There is a need for charging electric vehicles (EVs) wirelessly since it provides a more convenient, reliable, and safer charging option for EV customers. A wireless charging system using a double-sided <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LCC</i> compensation topology is proven to be highly efficient; however, the large volume induced by the compensation coils is a drawback. In order to make the system more compact, this paper proposes a new method to integrate the compensated coil into the main coil structure. With the proposed method, not only is the system more compact, but also the extra coupling effects resulting from the integration are either eliminated or minimized to a negligible level. Three-dimensional finite-element analysis tool ANSYS MAXWELL is employed to optimize the integrated coils, and detailed design procedures on improving system efficiency are also given in this paper. The wireless charging system with the proposed integration method is able to transfer 3.0 kW with 95.5% efficiency (overall dc to dc) at an air gap of 150 mm.
Linear pattern matching algorithms (1973)

In 1970, Knuth, Pratt, and Morris [1] showed how to do basic pattern matching in linear time. Related problems, such as those discussed in [4], have previously been solved by efficient but sub-optimal algorithms. In this paper, we introduce an interesting data structure called a bi-tree. A linear time algorithm for obtaining a compacted version of a bi-tree associated with a given string is presented. With this construction as the basic tool, we indicate how to solve several pattern matching problems, including some from [4] in linear time.
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors (2005)

The Raf family includes three members, of which B-Raf is frequently mutated in melanoma and other tumors. We show that Raf-1 and A-Raf require Hsp90 for stability, whereas B-Raf does not. In contrast, mutated, activated B-Raf binds to an Hsp90-cdc37 complex, which is required for its stability and function. Exposure of melanoma cells and tumors to the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in the degradation of mutant B-Raf, inhibition of mitogen-activated protein kinase activation and cell proliferation, induction of apoptosis, and antitumor activity. These data suggest that activated mutated B-Raf proteins are incompetent for folding in the absence of Hsp90, thus suggesting that the chaperone is required for the clonal evolution of melanomas and other tumors that depend on this mutation. Hsp90 inhibition represents a therapeutic strategy for the treatment of melanoma.
Natural Language Dialogue for Building and Learning Models and Structures (2017)

We demonstrate an integrated system for building and learning models and structures in both a real and virtual environment. The system combines natural language understanding, planning, and methods for composition of basic concepts into more complicated concepts. The user and the system interact via natural language to jointly plan and execute tasks involving building structures, with clarifications and demonstrations to teach the system along the way. We use the same architecture for building and simulating models of biology, demonstrating the general-purpose nature of the system where domain-specific knowledge is concentrated in sub-modules with the basic interaction remaining domain-independent. These capabilities are supported by our work on semantic parsing, which generates knowledge structures to be grounded in a physical representation, and composed with existing knowledge to create a dynamic plan for completing goals. Prior work on learning from natural language demonstrations enables learning of models from very few demonstrations, and features are extracted from definitions in natural language. We believe this architecture for interaction opens up a wide possibility of human-computer interaction and knowledge transfer through natural language.
Effectiveness of Heptavalent Pneumococcal Conjugate Vaccine in Children Younger Than 5 Years of Age for Prevention of Pneumonia (2006)

Using WHO criteria for reading of radiographs increased point estimates of vaccine efficacy presumably as a result of improved specificity.
Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle. (2007)

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a lipocalin that is well known for its functions as a shuttle for iron and siderophores, which comprises a critical component of innate immunity to exogenous bacterial infections. However, several lines of recent evidence have added new dimensions of functionality that have attracted the interest of cancer biologists and oncologists. This review will highlight the exciting new paths and roles that are emerging for NGAL in human cancers, in the tissue response to anticancer therapy, and in the acute kidney injuries that commonly complicate the care of patients with cancer. The evidence for NGAL induction and its role in various human cancers will be explored. The current status of NGAL as a predictive non-invasive biomarker of acute kidney injuries will also be examined.
Histologic findings at augmented bone areas supplied with two different bone substitute materials combined with sinus floor lifting (2004)

This case report is focused on the histologic findings of bone tissue supplied with two different hydroxyapatites (HAs) used for maxillary sinus floor grafting in the same patient after various healing intervals. An insufficient unilateral sinus floor grafting with Bio-Oss biomaterial was followed by an additional grafting procedure with Algipore biomaterial performed 4 years later. Bone samples obtained during second-stage dental implantation contained the interesting combination of Bio-Oss, a bovine anorganic bone substitute, and Algipore, a porous algae-derived HA, in close vicinity, yet after different healing periods. Light microscopy exhibited satisfactory osseointegration of both grafting materials. However, Bio-Oss biomaterial showed no evidence of substantial remodeling after a healing period of 4.5 years. On the other hand, Algipore particles demonstrated signs of remodeling by being locally resorbed and partially replaced with newly formed bone already within 6 months.
Hydrogen atom abstraction from resveratrol and two lipophilic derivatives by tert-butoxyl radicals. A laser flash photolysis study. (2004)

The reactions of tert-butoxyl radicals with resveratrol (1) and two acetylated derivatives (2 and 3) have been investigated by laser flash photolysis techniques in 1∶2 (v/v) benzene–di-tert-butyl peroxide at room temperature. The transient absorption spectra of the phenoxyl radicals generated upon H atom abstraction by tert-butoxyl radicals from the phenols have been detected and assigned. The absolute rate constants for these reactions have been evaluated to be 45 × 107, 25 × 107 and 4 × 107 M−1 s−1 for 1, 2 and 3, respectively. The order of reactivity 1 ≥ 2 ≫ 3 has been rationalized in terms of the position and effect of the acetyl groups on the aromatic rings. Of the three OH groups present in resveratrol, the one in position 4′ appears to be the most reactive due to the large stability of the corresponding phenoxyl radical by conjugation with the rings. However, in our system, the H-atom-donating ability of resveratrol turns out to be inferior to that of α-tocopherol by ca. one order of magnitude.
Reconstruction of the Central Carbohydrate Metabolism of Thermoproteus tenax by Use of Genomic and Biochemical Data (2004)

The hyperthermophilic, facultatively heterotrophic crenarchaeum Thermoproteus tenax was analyzed using a low-coverage shotgun-sequencing approach. A total of 1.81 Mbp (representing 98.5% of the total genome), with an average gap size of 100 bp and 5.3-fold coverage, are reported, giving insights into the genome of T. tenax. Genome analysis and biochemical studies enabled us to reconstruct its central carbohydrate metabolism. T. tenax uses a variant of the reversible Embden-Meyerhof-Parnas (EMP) pathway and two different variants of the Entner-Doudoroff (ED) pathway (a nonphosphorylative variant and a semiphosphorylative variant) for carbohydrate catabolism. For the EMP pathway some new, unexpected enzymes were identified. The semiphosphorylative ED pathway, hitherto supposed to be active only in halophiles, is found in T. tenax. No evidence for a functional pentose phosphate pathway, which is essential for the generation of pentoses and NADPH for anabolic purposes in bacteria and eucarya, is found in T. tenax. Most genes involved in the reversible citric acid cycle were identified, suggesting the presence of a functional oxidative cycle under heterotrophic growth conditions and a reductive cycle for CO2 fixation under autotrophic growth conditions. Almost all genes necessary for glycogen and trehalose metabolism were identified in the T. tenax genome.
Assessment of Peanut Pod Maturity (2017)

This paper concerns the assessment of peanut pod maturity through automated visual analysis of the middle layer of the shell, known as the mesocarp. Moisture in the mesocarp decreases with age, resulting in significant changes in color and rigidity. As peanuts mature, the color of the mesocarp gradually changes from white to yellow to dark brown, with progressively darker intensity levels. A technique is presented here in which pod maturity is estimated based on a combination of mesocarp color (visible-light wavelengths) and pod size. For each peanut pod, a voting procedure and nearest-neighbor classification are used to assign 1 of 10 color classes. The color class of each pod, together with the pod's size, are then used to assign 1 of 7 different maturity classes. In the experimental results reported here, precision and recall values for maturity classification were both 66.5%, as compared to classification by a human expert. The proportion of pods in the combined brown-black class, relative to the total sample size, can be used to estimate overall crop maturity. For this task, the automated system identified the number of brown-black peanuts per sample with an accuracy of 92.5%. This approach has strong potential for automatically determining suitable harvest dates for peanut crops.
Extendibility of laser scanning tools for advanced wafer inspection (1995)

This paper describes a broad range of design issues that influence the performance of optical equipment for in-line inspection of random (logic) and repetitive (memory) patterns. In particular, we describe the angular distribution of signals from defects on a patterned wafer illuminated by a focused optical beam. We analyze the configuration of both illumination and collection optics to maximize the signal to background ratio for the detection of submicron defects on pattern. In addition, we analyze the distribution of the scattered light as a function of pattern periodicity and orientation with respect to the illuminating beam. The advantages of polarization selection and spatial filtering techniques are explored to enhance the detection sensitivity on repetitive and random pattern wafers. From these results we have developed a new patterned wafer inspection system that offers increased sensitivity and improved defect capture.
High-Affinity Aptamers to Subtype 3a Hepatitis C Virus Polymerase Display Genotypic Specificity (2006)

Research into antiviral agents directed at hepatitis C virus (HCV) proteins is commonly based and tested on a single genotype, namely, genotype 1. This is despite the high level of variability of the RNA virus and the frequency of infection with genotypes other than genotype 1. The systematic evolution of ligands by exponential enrichment (SELEX) is a novel in vitro approach used in this study that allows rapid screening of vast nucleic acid libraries to isolate sequences (termed aptamers) that bind to target proteins with high affinity. The SELEX approach was used in the present study to isolate DNA aptamers to the RNA-dependent RNA polymerase (RdRp) (nonstructural protein 5B [NS5B]) of HCV subtype 3a, with the aim of inhibiting polymerase activity. Ten rounds of selection were performed using a Biacore 2000 as the partitioning system. Two aptamers, r10/43 and r10/47, were chosen for further studies on the basis of their abilities to bind the HCV RdRp and inhibit polymerase activity. The affinities (equilibrium dissociation constants) of these aptamers for the HCV subtype 3a polymerase were estimated to be 1.3 +/- 0.3 nM (r10/43) and 23.5 +/- 6.7 nM (r10/47). The inhibition constants of r10/43 and r10/47 were estimated to be 1.4 +/- 2.4 nM and 6.0 +/- 2.3 nM, respectively. Inhibition of HCV 3a polymerase was specific for r10/47, while r10/43 also demonstrated some inhibitory effect on norovirus and phi6 polymerase activity. Neither r10/43 nor r10/47 was able to inhibit the RdRp activity of HCV genotype 1a and 1b polymerases. This study is the first description of an inhibitor specific to the HCV subtype 3a polymerase.
Transfer of foreign DNA into the cells of developing mouse embryos by microprojectile bombardment (1993)

Mouse cells of developing embryos at the 2-4 cell, morula and blastocyst stages, were bombarded by high velocity tungsten microprojectiles. About 70% of developing embryos survived the bombardment. The general embryo structure did not change as a result of the bombardment. Penetration of the tungsten microparticles into the embryo cell nuclei was found at all stages being investigated, and tungsten particle localization on mitotic chromosomes was demonstrated. The total DNA of the mice born from the bombarded embryos was analyzed by dot-blot hybridization and PCR with post-hybridization. The most important results were obtained in experiments with blastocysts. In three cases of blastocyst bombardment, the presence of transferred plasmid DNA (pSV3-neo) was revealed. Transfected cells were shown to be located in the fetal membrane as well as in the embryo. The bombardment of mouse culture cells resulted in their transfection and the production of G418-resistant clones.
Thermodynamics of Block Copolymers with and without Salt (2013)

Ion-containing block copolymers are of interest for applications such as electrolytes in rechargeable lithium batteries. The addition of salt to these materials is necessary to make them conductive; however, even small amounts of salt can have significant effects on the phase behavior of these materials and consequently on their ion-transport and mechanical properties. As a result, the effect of salt addition on block copolymer thermodynamics has been the subject of significant interest over the past decade. This feature article describes a comprehensive study of the thermodynamics of block copolymer/salt mixtures over a wide range of molecular weights, compositions, salt concentrations, and temperatures. The Flory-Huggins interaction parameter was determined by fitting small-angle X-ray scattering data of disordered systems to predictions based on the random phase approximation. Experiments on neat block copolymers revealed that the Flory-Huggins parameter is a strong function of chain length. Experiments on block copolymer/salt mixtures revealed a highly nonlinear dependence of the Flory-Huggins parameter on salt concentration. These findings are a significant departure from previous results and indicate the need for improved theories for describing thermodynamic interactions in neat and salt-containing block copolymers.