gebhart/patrepeval huggingface dataset:
Impaired Neurogenic Vascular Response in Patients with Diabetes and Neuropathic Foot Lesions (1988)

Peripheral neuropathy plays an important part in the development of foot complications in patients with diabetes. We studied the contribution of impairment of the dual sensory and inflammatory function of unmyelinated nociceptive C fibers in the foot complications of diabetes. The integrity of these fibers was assessed objectively by measuring axon reflex vasodilation in response to stimulation with 10 percent acetylcholine introduced by electrophoresis. This was related to the non-neurogenic capacity of the vessels to dilate in response to a mechanical stroke. These measurements were made on the soles of the subjects' feet. The function of the nociceptive C fibers was abnormal in 1 of 14 patients with longstanding diabetes who had no foot complications, 3 of 9 patients with diabetes and skin sepsis, 8 of 11 patients with typical neuropathic plantar ulcers, and all of 8 patients with neuroarthropathy. In patients with longstanding diabetes but no foot complications, the mean ratio of neurogenic to non-neurogenic vasodilation was not significantly different from that in controls; however, it was significantly lower in the other three groups (P less than 0.01 for those with sepsis; P less than 0.001 for those with ulcer or arthropathy). Impairment of the neurogenic vasodilator response, or flare, correlated with the clinical diminution of pain sensation. This study suggests that the loss of both components of nociceptive C-fiber function--neurogenic inflammation and pain sensation--is an important factor in the development of foot complications in diabetes.
Assessment of urinary β-core fragment of human chorionic gonadotropin as a new tumor marker of lung cancer (1994)

Ectopic production of IR-beta by lung cancer is not rare, and urinary beta-CF might be a potential tumor marker of lung cancer.
A new anti-mesothelin antibody targets selectively the membrane-associated form (2017)

Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that shows promise as a target for antibody-directed cancer therapy. High levels of soluble forms of the antigen represent a barrier to directing therapy to cellular targets. The ability to develop antibodies that can selectively discriminate between membrane-bound and soluble conformations of a specific protein, and thus target only the membrane-associated antigen, is a substantive issue. We show that use of a tolerance protocol provides a route to such discrimination. Mice were tolerized with soluble mesothelin and a second round of immunizations was performed using mesothelin transfected P815 cells. RNA extracted from splenocytes was used in phage display to obtain mesothelin-specific antigen-binding fragments (Fabs) that were subsequently screened by flow cytometry and ELISA. This approach generated 147 different Fabs in 34 VH-CDR3 families. Utilizing competition assays with soluble protein and mesothelin-containing serum obtained from metastatic cancer patients, 10 of these 34 VH-CDR3 families were found to bind exclusively to the membrane-associated form of mesothelin. Epitope mapping performed for the 1H7 clone showed that it does not recognize GPI anchor. VH-CDR3 sequence analysis of all Fabs showed significant differences between Fabs selective for the membrane-associated form of the antigen and those that recognize both membrane bound and soluble forms. This work demonstrates the potential to generate an antibody specific to the membrane-bound form of mesothelin. 1H7 offers potential for therapeutic application against mesothelin-bearing tumors, which would be largely unaffected by the presence of the soluble antigen.
Computer methods for mathematical computations (1977)

https://works.swarthmore.edu/alum-books/2954/thumbnail.jpg
Self-assembled phospholipid/alkanethiol biomimetic bilayers on gold (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembled phospholipid/alkanethiol biomimetic bilayers on goldAnne L. PlantCite this: Langmuir 1993, 9, 11, 2764–2767Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://doi.org/10.1021/la00035a004RIGHTS & PERMISSIONSArticle Views1738Altmetric-Citations288LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (545 KB) Get e-Alerts Get e-Alerts
DLBC: A Deep Learning-Based Consensus in Blockchains for Deep Learning Services (2019)

With the increasing artificial intelligence application, deep neural network (DNN) has become an emerging task. However, to train a good deep learning model will suffer from enormous computation cost and energy consumption. Recently, blockchain has been widely used, and during its operation, a huge amount of computation resources are wasted for the Proof of Work (PoW) consensus. In this paper, we propose DLBC to exploit the computation power of miners for deep learning training as proof of useful work instead of calculating hash values. it distinguishes itself from recent proof of useful work mechanisms by addressing various limitations of them. Specifically, DLBC handles multiple tasks, larger model and training datasets, and introduces a comprehensive ranking mechanism that considers tasks difficulty(e.g., model complexity, network burden, data size, queue length). We also applied DNN-watermark [1] to improve the robustness. In Section V, the average overhead of digital signature is 1.25, 0.001, 0.002 and 0.98 seconds, respectively, and the average overhead of network is 3.77, 3.01, 0.37 and 0.41 seconds, respectively. Embedding a watermark takes 3 epochs and removing a watermark takes 30 epochs. This penalty of removing watermark will prevent attackers from stealing, improving, and resubmitting DL models from honest miners.
Turbo codes for PCS applications (2002)

Turbo codes are the most exciting and potentially important development in coding theory in many years. They were introduced in 1993 by Berrou, Glavieux and Thitimajshima, and claimed to achieve near Shannon-limit error correction performance with relatively simple component codes and large interleavers. A required E/sub b//N/sub o/ of 0.7 dB was reported for BER of 10/sup -5/ and code rate of 1/2. However, some important details that are necessary to reproduce these results were omitted. This paper confirms the accuracy of these claims, and presents a complete description of an encoder/decoder pair that could be suitable for PCS applications. We describe a new simple method for trellis termination, we analyze the effect of interleaver choice on the weight distribution of the code, and we introduce the use of unequal rate component codes which yields better performance. Turbo codes are extended to encoders with multiple codes and a suitable decoder structure is developed, which is substantially different from the decoder for two-code based encoders.
Change of Oxygen Uptake, Heart Rate, Blood Pressure with Body Fat Rate in AM and PM (2005)

Abstract : The purpose of this study was to investigate the effect of body fat on energy metabolic response and subjective sensations under the hot environment. Fifteen female university students volunteered as subjects. We organized subjects into three groups: low body fat group(group L : less than 20% of body fat), medium body fat group(group M : 20% ~ 30% of body fat) and high body fat group(group H: more than 30% of body fat). The experiment was conducted with 32 o C, 60%RH. The subjects repeated ‘Exercise’ and ‘Rest’ period. The results of this study are as follows ; The oxygen uptake value of AM is higher than PM. The value of group H is the highest in three fat groups. But it showed group L is the highest in oxygen uptake per weight. %body fat is the lower, oxygen uptake is the higher. In Calorie, group L has higher value in AM in than in PM. In M group and group H, a value of PM is higher than AM. In group H, difference of AM and PM is the highest. From a view point of three groups, a value of group H is the highest. This support that calorie increases as oxygen uptake increase. The heart rate values of group L and group H are the higher in AM than in PM. This support that heart rate was relation to oxygen uptake. In all three groups, the value of blood pressure is higher in AM than in PM. Subjective sensations of temperature sensation, thermal comfort, and wetness sensation are higher in Am than in Pm. This explains that subject sensations are similar to experimental data, such as oxygen uptake, heart rate, blood pressure. In oxygen uptake, heart rate and blood pressure, general tend to showed higher AM than PM. This showed that heart rate, oxygen uptake increase in AM, as blood pressure increase, too. From a view point of %body fat, group H is higher than the others in oxygen uptake, heart rate and blood pressure.Key words : body fat, oxygen uptake, heart rate, blood pressure, subject sensation, AM, PM
RADIOIMMUNODETECTION OF CANCER USING ANTIBODIES TO α‐FETOPROTEIN AND CARCINOEMBRYONIC ANTIGEN (1983)

This study reports the use of radiolabeled antibody to AFP and CEA for the detection and localization of AFP- or CEA-producing tumors. Thirty-one patients received 131I-labeled anti-AFP or anti-CEA antibodies. Photoscans were taken at 24 and 48 hours after injection of radioantibodies. In three of six patients with CEA-producing tumors, radioimmunodetection with anti-CEA antibody showed positive scans. In AFP-producing tumors, 7 of 15 patients had positive findings on immunoscintigraphy using polyclonal anti-AFP antibody, and two of nine patients had positive findings when monoclonal antibodies were used. Analysis of radioantibody in the blood after injection showed both complex and free antibody with immunoreactivity in the circulation, and smaller complexes were seen to form after administration of monoclonal antibodies.
Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles (2007)

The pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orally delivered nanoparticles lowered basal serum glucose levels in diabetic rats around 35% with 50 and 100 IU/kg doses sustaining hypoglycemia over 24 h. Pharmacological availability was 5.6 and 3.4% for the 50 and 100 IU/kg doses, respectively, a significant increase over 1.6%, determined for oral insulin alone in solution. Confocal microscopic examinations of FITC-labeled insulin nanoparticles showed adhesion to rat intestinal epithelium, and internalization of insulin within the intestinal mucosa. Encapsulation of insulin into dextran sulfate/chitosan nanoparticles was a key factor in the improvement of the bioavailability of its oral delivery over insulin solution.
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70 (2000)

Heat shock proteins 70 (hsp70) derived from tissues and cells can elicit cytotoxic T lymphocyte (CTL) responses against peptides bound to hsp70. However, peptides can markedly differ in their affinity for hsp, and this potentially limits the repertoire of peptides available to induce CTL by the hsp immunization. Hybrid peptides consisting of a high-affinity ligand for the peptide-binding site of hsp70 joined to T cell epitopes by a glycine-serine-glycine linker were constructed. Immunization with hybrid peptides complexed to mouse hsp70 effectively primed specific CTL responses in mice and were more potent than T cell peptide epitopes alone with hsp70. In vivo immunization with hsp70 and hybrid peptides led to rejection of tumors expressing antigen with greater efficacy than immunization with peptide epitope plus hsp70. Induction of CTL responses occurred independently of CD4(+) T cells, suggesting that immunization directly primed antigen-presenting cells to elicit CD8(+) cytotoxic T cell responses without T cell help. Both peptide/hsp70 complexes and mouse hsp70 alone were able to induce cultures of mouse bone marrow-derived dendritic cells (DC) to release cytokines, including DC from endotoxin-resistant C57BL/10Sc mice. Thus, hsp70/hybrid peptide complexes can activate DC for cytokine release, providing a potential adjuvant effect that could bypass T cell help.
Force fields for silicas and aluminophosphates based onab initiocalculations (1990)

We address the problem of finding interatomic force fields for silicas from ab initio calculations on small clusters. It is shown that the force field cannot be determined from cluster data alone; incorporation of bulk-system information into the force field remains essential. Bearing this in mind, we derive a force field based on both microscopic (ab initio) and macroscopic (experimental) data. This force field combines accuracy with transferability to other polymorphs. The possibility of parametrizing other elements is also demonstrated.
A Wireless Monitoring System for Pulse-Oximetry Sensors (2005)

This paper presents a wireless medical monitoring system. The system permits to receive and process in a single concentrator node (e.g. a laptop or a simple handheld device) the pulse-oximetry signals from one ore several monitored patients without using any wired infrastructure. The system, which is based on a piconet of Bluetooth sensors, can retransmit the medical signals by WLAN and GPRS. The paper describes the practical application scenarios in which this type of systems could be of great utility.
A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit. (1994)

Escherichia coli enterotoxin (LT) and the homologous cholera toxin (CT) are A-B toxins that cause travelers' diarrhea and cholera, respectively. So far, experimental live and killed vaccines against these diseases have been developed using only the nontoxic B portion of these toxins. The enzymatically active A subunit has not been used because it is responsible for the toxicity and it is reported to induce a negligible titer of toxin neutralizing antibodies. We used site-directed mutagenesis to inactivate the ADP-ribosyltransferase activity of the A subunit and obtained nontoxic derivatives of LT that elicited a good titer of neutralizing antibodies recognizing the A subunit. These LT mutants and equivalent mutants of CT may be used to improve live and killed vaccines against cholera and enterotoxinogenic E. coli.
Driver Gaze Region Estimation without Use of Eye Movement (2016)

Automated estimation of the allocation of a driver's visual attention could be a critical component of future advanced driver assistance systems. In theory, vision-based tracking of the eye can provide a good estimate of gaze location. But in practice, eye tracking from video is challenging because of sunglasses, eyeglass reflections, lighting conditions, occlusions, motion blur, and other factors. Estimation of head pose, on the other hand, is robust to many of these effects but can't provide as fine-grained of a resolution in localizing the gaze. For the purpose of keeping the driver safe, it's sufficient to partition gaze into regions. In this effort, a proposed system extracts facial features and classifies their spatial configuration into six regions in real time. The proposed method achieves an average accuracy of 91.4 percent at an average decision rate of 11 Hz on a dataset of 50 drivers from an on-road study.
Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype (2011)

These proteins may have an important role in sustaining high productivity of recombinant protein over the duration of a fed-batch bioprocess culture. It is possible that many of these proteins could be useful for future approaches to successfully manipulate or engineer CHO cells in order to sustain productivity of recombinant protein.
Underlying coronary artery disease and successful bone marrow transplantation: a case report. (1994)

The cardiovascular risk of concurrent coronary artery disease in patients undergoing bone marrow transplantation (BMT) is not well known. We present a case of a 32-year-old male Hodgkin's disease patient with prior chemotherapy and radiotherapy, who underwent autologous BMT. His underlying single vessel coronary artery disease was well documented and he suffered no post-autologous BMT cardiotoxicity.
Covalent structure of biodegradative threonine dehydratase of Escherichia coli: homology with other dehydratases. (1987)

The 987-base-pair coding region of the tdc gene of Escherichia coli K-12 encoding biodegradative threonine dehydratase [Tdc; L-threonine hydro-lyase (deaminating), EC 4.2.1.16], previously cloned in this laboratory, was sequenced. The deduced polypeptide consists of 329 amino acid residues with a calculated Mr of 35,238. Although the purified enzyme was shown to contain tryptophan, no tryptophan codon was found in the tdc reading frame. Incubation of purified Tdc with [14C]tryptophan revealed apparent "covalent" binding of tryptophan, indicating posttranslational modification of the enzyme. A heptapeptide, 54Thr-55Gly-56Ser-57Phe-58Lys-59Ile- 60Arg, was found to contain Lys-58, which binds pyridoxal phosphate coenzyme. A comparison of amino acid sequences between the Tdc polypeptide and the biosynthetic threonine dehydratases of yeast (encoded by ILV1) and E. coli (encoded by ilvA) and the E. coli D-serine dehydratase (DsdA, encoded by dsdA) revealed various extents of homology: five domains of the Tdc polypeptide were 63-93% homologous with the yeast enzyme, and three of these same regions were 80% homologous with the biosynthetic E. coli dehydratase; two different domains showed 67% and 83% homology with DsdA. In addition, two other sequences were highly conserved in all four proteins, one of which was shown to contain the conserved lysine residue that binds pyridoxal phosphate in the Tdc and DsdA polypeptides. These observations suggest that, despite their diverse origin and metabolic significance, these enzymes may have evolved from a common ancestral protein.
Novel human light chain V kappa segment: serologic and structural analyses of the kappa III-like Bence Jones protein and IgG kappa light chain REE. (1986)

Immunochemical and sequence analyses of kappa light chain REE (Bence Jones protein REE and the light chain isolated from IgG kappa myeloma protein REE) revealed antigenic and structural features not previously described for human kappa-chains. Although closely related to proteins of the V kappa III subgroup, light chain REE is readily distinguished from light chains classified serologically as members of the kappa IIIa or kappa IIIb sub-subgroups. Light chains REE (Bence Jones protein REE and light chain REE) are identical in sequence and differ from kappa III proteins by at least 10 uncommon amino acid substitutions in the first three framework regions. Further, kappa-chain REE is unique by virtue of a four-residue deletion in the third complementarity-determining region. The deletion encompasses the three carboxyl-terminal residues in the V kappa-encoded segment and the first residue at the site of V-J recombination. Urine specimens from patient REE also contained a light chain fragment that lacked the first (amino-terminal) 85 residues of the native light chain but otherwise was identical in sequence to the light chain REE. The extensive amino acid differences and unique length of the V kappa segment in light chain REE indicate that this kappa-chain is the product of an unusual V kappa III gene or, alternatively, represents a rarely expressed and novel human V kappa gene.
D-Limonene: safety and clinical applications. (2007)

D-limonene is one of the most common terpenes in nature. It is a major constituent in several citrus oils (orange, lemon, mandarin, lime, and grapefruit). D-limonene is listed in the Code of Federal Regulations as generally recognized as safe (GRAS) for a flavoring agent and can be found in common food items such as fruit juices, soft drinks, baked goods, ice cream, and pudding. D-limonene is considered to have fairly low toxicity. It has been tested for carcinogenicity in mice and rats. Although initial results showed d-limonene increased the incidence of renal tubular tumors in male rats, female rats and mice in both genders showed no evidence of any tumor. Subsequent studies have determined how these tumors occur and established that d-limonene does not pose a mutagenic, carcinogenic, or nephrotoxic risk to humans. In humans, d-limonene has demonstrated low toxicity after single and repeated dosing for up to one year. Being a solvent of cholesterol, d-limonene has been used clinically to dissolve cholesterol-containing gallstones. Because of its gastric acid neutralizing effect and its support of normal peristalsis, it has also been used for relief of heartburn and gastroesophageal reflux (GERD). D-limonene has well-established chemopreventive activity against many types of cancer. Evidence from a phase I clinical trial demonstrated a partial response in a patient with breast cancer and stable disease for more than six months in three patients with colorectal cancer.
Subnanomolar detection limit for sodium dodecyl sulfate — capillary gel electrophoresis using a fluorogenic, noncovalent dye (1998)

Picomolar limits of detection are obtained using the noncovalent, fluorogenic dye, Sypro Red. The size separation of four commonly used sodium dodecyl sulfate-capillary gel electrophoresis (SDS-CGE) molecular weight markers with 8% linear polyacrylamide (PAA) as the sieving matrix is used to construct a calibration curve for molecular weight determinations. SDS-CGE purity and molecular weight determination of purified chorismate mutase-prephenate dehydrogenase (CMPD) from Escherichia coli is shown to be comparable in accuracy with slab gel SDS-polyacrylamide gel electrophoresis (SDS-PAGE). A migration time precision study indicates excellent reproducibility. Sypro red labeling of SDS-bovine serum albumin (SDS-BSA) complexes at nanomolar protein concentrations suggests assay detection limits surpassing those of silver staining. This detectability exceeds that achieved in previous SDS-CGE laser-induced fluorescence studies. This approach is expected to be easily adapted for use with commercial polymer formulations and automated instrumentation.