Rhabdomyolysis and Acute Renal Failure Induced by Combination Lovastatin and Gemfibrozil Therapy (1990)

Brief Reports1 February 1990Rhabdomyolysis and Acute Renal Failure Induced by Combination Lovastatin and Gemfibrozil TherapyGary E. Marais, MB, ChB, Kerry K. Larson, MDGary E. Marais, MB, ChB, Kerry K. Larson, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-3-228 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLovastatin is a new lipid-lowering drug that has shown great promise in the treatment of patients with hypercholesterolemia (1, 2). It is the first available agent in a new class of drugs that inhibit the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the rate-limiting step in cholesterol synthesis (3). Lovastatin is well tolerated and few severe adverse effects have been reported (4). Myopathy, defined as muscle pain or weakness associated with markedly elevated creatine kinase levels, has a reported incidence of 0.5% (4). Rhabdomyolysis has been reported in 30% of patients when the drug is used concomitantly with immunosuppressive drugs...References1. HavelHunninghakeIllingworth RDD. Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia. A multicenter study. Ann Intern Med. 1987;107:609-15. LinkGoogle Scholar2. . Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. JAMA. 1986;256:2829-34. CrossrefMedlineGoogle Scholar3. Grundy S. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl J Med. 1988;319:24-33. CrossrefMedlineGoogle Scholar4. Tobert J. Efficacy and long-term adverse effect pattern of lovastatin. Am J Cardiol. 1988;62:28J-34J. CrossrefMedlineGoogle Scholar5. NormanIllingworthMunsonHosenpud DDJJ. Myolysis and acute renal failure in a heart-transplant patient receiving lovastatin [Letter]. N Engl J Med. 1988;318:46-7. CrossrefMedlineGoogle Scholar6. EastAlivizatosGrundyJonesFarmer CPSPJ. Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation [Letter]. N Engl J Med. 1988;318:47-8. CrossrefMedlineGoogle Scholar7. Tobert J. Reply. N Engl J Med. 1988;318:48. MedlineGoogle Scholar8. ReavenWitztum PJ. Lovastatin, nicotinic acid, and rhabdomyolysis. Ann Intern Med. 1988;109:597-8. LinkGoogle Scholar9. AyanianFuchsStone JCR. Lovastatin and rhabdomyolysis [Letter]. Ann Intern Med. 1988;109:682-3. LinkGoogle Scholar10. CorpierJonesSuki CPW. Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. JAMA. 1988;260:239-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Jerry L. Pettis Memorial Veterans Hospital, Loma Linda, California. For current author addresses, see end of text. 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