gebhart/patrepeval huggingface dataset:
Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain (2000)

We have identified a type I cytokine receptor, which we have termed novel interleukin receptor (NILR), that is most related to the IL-2 receptor beta chain (IL-2Rbeta) and physically adjacent to the IL-4 receptor alpha chain gene on chromosome 16. NILR mRNA is most highly expressed in thymus and spleen, and is induced by phytohemagglutinin in human peripheral blood mononuclear cells. NILR protein was detected on human T cell lymphotropic virus type I-transformed T cell lines, Raji B cells, and YT natural killer-like cells. Artificial homodimerization of the NILR cytoplasmic domain confers proliferation to Ba/F3 murine pro-B cells but not to 32D myeloid progenitor cells or CTLL-2 murine helper T cells. In these latter cells, heterodimerization of IL-2Rbeta and the common cytokine receptor gamma chain (gamma(c)) cytoplasmic domains allows potent proliferation, whereas such heterodimerization of NILR with gamma(c) does not. This finding suggests that NILR has signaling potential but that a full understanding of its signaling partner(s) is not yet clear. Like IL-2Rbeta, NILR associates with Jak1 and mediates Stat5 activation.
Understanding of suspension DC plasma spraying of finely structured coatings for SOFC (2005)

Suspension plasma spraying was used to achieve a dense and thin (/spl sim/30 /spl mu/m) yttria stabilized zirconia (YSZ) coating for the electrolyte of solid oxide fuel cells (SOFCs). A suspension of YSZ powder (d/sub 50//spl sim/1 /spl mu/m) was mechanically injected in direct current (dc) plasma jets. The plasma jet acted as an atomizer and the suspension drops (d/spl sim/200 /spl mu/m) were sheared, long before they started vaporizing, into many droplets (d/spl sim/2 /spl mu/m). The solvent of the latters was then very rapidly (a few microseconds) evaporated and decomposed by the plasma jet. The solid particles enclosed in each droplet were then accelerated and melted before impacting on the substrate where they formed splats. The thermal inertia of particles with sizes below 1 /spl mu/m being low, the standoff distance was much shorter than in conventional plasma spraying (40-60 against 100-120 mm). Thus, the heat flux from the plasma to the coating reached 20 MW/spl middot/m/sup -2/ when spraying YSZ suspensions with Ar-H/sub 2/ or Ar-H/sub 2/-He plasma jets. It allowed keeping the whole pass (about 0.8-/spl mu/m-thick) completely molten resulting after its solidification, for YSZ, in a fully dense coating (20-30-/spl mu/m-thick) with a granular microstructure.
Facing the Music on the Internet: Identifying Divergent Strategies for Different Segments of the Music Industry in Approaching Digital Distribution (1999)

Diamond Multimedia's Rio was the first of the walkman-type portable players of digital downloads. The latest version of the Rio, the Special Edition Rio PMP300 carries 64 megabytes of memory, which is twice the original, which was released less than a year ago. Furthermore, the English technology company Empeg has begun to offer an MP3 car stereo with the capacity to play 476 hours of music.
Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A department of veterans affairs cooperative study (1996)

SSZ at a dosage of 2,000 mg/day is well tolerated and may be more effective than placebo in the treatment of patients with PsA.
Anxiety Dissociates Dorsal and Ventral Medial Prefrontal Cortex Functional Connectivity with the Amygdala at Rest (2010)

Anxiety is linked to compromised interactions between the amygdala and the dorsal and ventral medial prefrontal cortex (mPFC). While numerous task-based neuroimaging studies show that anxiety levels predict amygdala-mPFC connectivity and response magnitude, here we tested the hypothesis that anxiety would predict functional connectivity between these brain regions even during rest. Resting-state functional magnetic resonance imaging scans and self-reported measures of anxiety were acquired from healthy subjects. At rest, individuals with high anxiety were characterized by negatively correlated amygdala-ventral mPFC functional connectivity, while low anxious subjects showed positively correlated activity. Further, high anxious subjects showed amygdala-dorsal mPFC activity that was uncorrelated, while low anxious subjects showed negatively correlated activity. These data show that amygdala-mPFC connectivity at rest indexes normal individual differences in anxiety.
Resistance to Antigen-Induced Airway Hyperresponsiveness Requires Endogenous Production of IL-12 (1998)

We have demonstrated previously that susceptibility of murine strains to the development of allergic airway responses is associated with a type 2 cytokine pattern. In the present study, we examine the in vivo role of IL-12 in the immune response to allergen exposure in susceptible (A/J) and resistant (C3H/HeJ, C3H) strains of mice. OVA sensitization and challenge induced significant increases in airway reactivity in A/J mice as compared with their PBS-challenged controls, while no increases in airway reactivity were observed in OVA-challenged C3H mice. OVA exposure of A/J mice resulted in marked increases in the Th2 cytokines, IL-4 and IL-10, in the bronchoalveolar lavage fluid, whereas increases in IFN-gamma were observed in C3H mice. Strikingly, anti-IL-12 mAb (1 mg/mouse) treatment resulted in threefold increases in airway reactivity in OVA-challenged resistant C3H mice, concomitant with significant increases in bronchoalveolar lavage levels of Th2 cytokines and decreases in IFN-gamma. IL-12 depletion of C3H mice also suppressed OVA-specific serum IgG2a levels and increased both serum OVA-specific IgG1 and IgE levels. Blockade of endogenous IL-12 levels in susceptible A/J mice resulted in further augmentation of type 2 immune responses. These results demonstrate that endogenous production of IL-12 is essential for resistance to Ag-induced airway hyperresponsiveness, and furthermore, that dysregulation of IL-12 production may lead to the development of deleterious type 2 immune responses to inhaled allergens.
Toward a global maximization of the molecular similarity function: Superposition of two molecules (1997)

A quantum similarity measure between two molecules is normally identified with the maximum value of the overlap of the corresponding molecular electron densities. The electron density overlap is a function of the mutual positioning of the compared molecules, requiring the measurement of similarity, a solution of a multiple-maxima problem. Collapsing the molecular electron densities into the nuclei provides the essential information toward a global maximization of the overlap similarity function, the maximization of which, in this limit case, appears to be related to the so-called assignment problem. Three levels of approach are then proposed for a global search scanning of the similarity function. In addition, atom—atom similarity Lorentzian potential functions are defined for a rapid completion of the function scanning. Performance is tested among these three levels of simplification and the Monte Carlo and simplex methods. Results reveal the present algorithms as accurate, rapid, and unbiased techniques for density-based molecular alignments. © 1997 by John Wiley & Sons, Inc. J Comput Chem 18: 826–846, 1997
Managing Network Reservation for Tenants in Oversubscribed Clouds (2013)

As businesses move their critical IT operations to multi-tenant cloud data centers, it is becoming increasingly important to provide network performance guarantees to individual tenants. Due to the impact of network congestion on the performance of many common cloud applications, recent work has focused on enabling network reservation for individual tenants. Current network reservation methods, however, do not gracefully degrade in the presence of network over subscriptions that may frequently occur in a cloud environment. In this context, for a shared data center network, we introduce Network Satisfaction Ratio (NSR) as a measure of the satisfaction derived by a tenant from a given network reservation. NSR is defined as the ratio of the actual reserved bandwidth to the desired bandwidth of the tenant. Based on NSR, we present a novel network reservation mechanism that can admit time-varying tenant requests and can fairly distribute any degradation in the NSR among the tenants in presence of network over subscription. We evaluate the proposed method using both synthetic network traffic trace and representative data center traffic trace generated by running a reduced data center job trace in a small test bed. The evaluation shows that our method adapts to changes in network reservations, and it provides significant and fair improvement in NSR when the data center network is oversubscribed.
Analysis of human papillomavirus type 16 E6-E7 transcription in cervical carcinomas and normal cervical epithelium using the polymerase chain reaction (1990)

Cervical biopsies were collected from Birmingham women having cervical intraepithelial neoplasia or invasive cervical carcinoma and normal controls, and examined for the presence of human papillomavirus type 16 (HPV-16) E6-E7 DNA and mRNA using an adaptation of the polymerase chain reaction. HPV-16 E6-E7 sequences were detected in all abnormal biopsies and in 90% of the normal biopsies examined, confirming previous studies describing the high prevalence of cervical HPV-16 infection. While we were unable to identify any qualitative differences in RNA transcripts from the p97 promoter, substantial quantitative differences in HPV-16-specific early region transcripts between normal and cytologically abnormal cervices were observed. These results suggest that although the level of E6-E7 transcription may contribute to the malignant phenotype, additional factors are likely to be important in the development of cervical neoplasia.
Remote plethysmographic imaging using ambient light (2008)

Plethysmographic signals were measured remotely (> 1m) using ambient light and a simple consumer level digital camera in movie mode. Heart and respiration rates could be quantified up to several harmonics. Although the green channel featuring the strongest plethysmographic signal, corresponding to an absorption peak by (oxy-) hemoglobin, the red and blue channels also contained plethysmographic information. The results show that ambient light photo-plethysmography may be useful for medical purposes such as characterization of vascular skin lesions (e.g., port wine stains) and remote sensing of vital signs (e.g., heart and respiration rates) for triage or sports purposes.
Pegylated interferon α enhances recovery of memory T cells in e antigen positive chronic hepatitis B patients (2012)

Pegylated IFN-α treatment enhanced recovery of memory T cells in CHB patients by down-regulating inhibitory receptors and up-regulating effector molecules. The expressions of CXCR4 and CD127 in CD8 memory T cell may be used as biomarkers for predicting the outcome of treatment.
High-Throughput Screening of Solid-State Li-Ion Conductors Using Lattice-Dynamics Descriptors (2019)

Low lithium-ion migration barriers have recently been associated with low average vibrational frequencies or phonon band centers, further helping identify descriptors for superionic conduction. To further explore this correlation, here we present the computational screening of ∼14,000 Li-containing compounds in the Materials Project database using a descriptor based on lattice dynamics reported recently to identify new promising Li-ion conductors. An efficient computational approach was optimized to compute the average vibrational frequency or phonon band center of ∼1,200 compounds obtained after pre-screening based on structural stability, band gap, and their composition. Combining a low computed Li phonon band center with large computed electrochemical stability window and structural stability, 18 compounds were predicted to be promising Li-ion conductors, one of which, Li<sub>3</sub>ErCl<sub>6</sub>, has been synthesized and exhibits a reasonably high room-temperature conductivity of 0.05-0.3 mS/cm, which shows the promise of Li-ion conductor discovery based on lattice dynamics.
Self-Renewal and Differentiation Capacity of Urine-Derived Stem Cells after Urine Preservation for 24 Hours (2013)

Despite successful approaches to preserve organs, tissues, and isolated cells, the maintenance of stem cell viability and function in body fluids during storage for cell distribution and transportation remains unexplored. The aim of this study was to characterize urine-derived stem cells (USCs) after optimal preservation of urine specimens for up to 24 hours. A total of 415 urine specimens were collected from 12 healthy men (age range 20-54 years old). About 6610 4 cells shed off from the urinary tract system in 24 hours. At least 100 USC clones were obtained from the stored urine specimens after 24 hours and maintained similar biological features to fresh USCs. The stored USCs had a ''rice grain'' shape in primary culture, and expressed mesenchymal stem cell surface markers, high telomerase activity, and normal karyotypes. Importantly, the preserved cells retained bipotent differentiation capacity. Differentiated USCs expressed myogenic specific proteins and contractile function when exposed to myogenic differentiation medium, and they expressed urothelial cell-specific markers and barrier function when exposed to urothelial differentiation medium. These data demonstrated that up to 75% of fresh USCs can be safely persevered in urine for 24 hours and that these cells stored in urine retain their original stem cell properties, indicating that preserved USCs could be available for potential use in cell-based therapy or clinical diagnosis.
Collective entity linking in web text (2011)

Entity Linking (EL) is the task of linking name mentions in Web text with their referent entities in a knowledge base. Traditional EL methods usually link name mentions in a document by assuming them to be independent. However, there is often additional interdependence between different EL decisions, i.e., the entities in the same document should be semantically related to each other. In these cases, Collective Entity Linking, in which the name mentions in the same document are linked jointly by exploiting the interdependence between them, can improve the entity linking accuracy.
The relationship of the compressive modulus of articular cartilage with its deformation response to cyclic loading: does cartilage optimize its modulus so as to minimize the strains arising in it due to the prevalent loading regime? (2001)

The viscous and elastic components of matrix strain, the creep rate and the cartilage compressive modulus were measured. The latter was found to be significantly related to the strain response of cartilage to cyclic loading. Elastic strain varied exponentially with the compressive modulus; specimens with a modulus less than 4 MPa experienced elastic strains in the range 0.18-0.36, whereas stiffer specimens experienced strains between 0.05 and 0.13. Viscous strain varied linearly with cartilage stiffness and was as low as 0.02 at the lower values of the compressive modulus but increased to 0.22 for a compressive modulus of 18 MN/m(2). The rate of creep under cyclic load was inversely linearly related to cartilage stiffness. The strain response of soft specimens approached steady state by 200 cycles but that of stiff specimens did not approach it until 1300 cycles. It was hypothesized that the viscous strain response of cartilage can be explained in terms of differences in permeability between specimens of different compressive modulus, stiffer cartilage having a lower permeability than soft cartilage.
DNA Helicases (1979)

In summary, we postulate that DNA unwinding and ATP dephosphorylation are coupled in different ways, depending on whether the fibrous ATPase or one of the globular ATPases provides the catalytic agent. Unanswered is the question of whether there is stoichiometry of ATP utilization during the unwinding of a duplex, and unsolved is the role of the individual enzyme in the cell.
Electrodeposition of Copper (2010)

This chapter contains sections titled: History and Development Applications Principles Functions of Solution Constituents Addition Agents Operating Conditions Effects of Impurities in Plating Solutions Analytical Methods Properties and Structure Current Modulation Techniques Plating on Steel, Zinc, Plastics, and Aluminum Plating of Printed Wiring Boards Patterned Electrodepqsition for Microelectronics Electroforming High-Speed Electroplating Diamond Turning Miscellaneous History and Development Applications Functions of Major Solution Constituents Comparison of Sodium and Potassium Formulations Addition Agents Solution Types: Strike and Rochelle Solutions Operating Conditions and Solution Characteristics Maintenance and Control High-Efficiency Cyanide Copper Solutions Operating Conditions and Solution Characteristics Maintenance and Control Anodes Materials of Construction Environmental Structure and Properties History and Development Applications Basic Chemistry Constituents Maintenance and Control Structure and Properties Plating of Printed Wiring Boards Alumina Properties Mechanism Continuous Fiber-Reinforced Composites References
Detailed Studies on Substrate Structure Requirements of Glycoamidases A and F (1997)

Glycoamidases (peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase, EC 3.5.1.52; also known as peptide: N-glycanases (PNGases) release N-linked oligosaccharides from glycopeptides and/or glycoproteins by hydrolyzing the glycosylated beta-amide bond of the asparagine side chain. The most widely used glycoamidases are those from Flavobacterium meningosepticum (glycoamidase F or PNGase F) and almond emulsin (glycoamidase A or PNGase A). To study the substrate structure requirement of these enzymes systematically, we synthesized >30 glycopeptides containing cellobiose, lactose, GlcNAc, and di-N,N'-acetylchitobiose (CTB). The length of the peptide was varied from one to five amino acids, and glycosylamines were linked to either Asn or Gln located at different positions in the peptide, including NH2 and COOH termini. Neither enzyme could cleave cellobiose and lactose glycopeptides, indicating that the 2-acetamido group on the Asn-linked GlcNAc is important in the recognition by both glycoamidases A and F. GlcNAc peptides could be cleaved by both enzymes, albeit not as effectively as CTB glycopeptides. Neither enzyme requires the Asn-Xaa-(Ser/Thr) sequence (required for N-glycosylation) for activity. Glycoamidase A could even hydrolyze a Gln-bound CTB glycopeptide, whereas the action of glycoamidase F on this substrate is minimal. While glycoamidase A could act on CTB dipeptides, glycoamidase F preferred a tripeptide or longer. The Km and Vmax values of glycoamidase A for t-butoxycarbonyl-(CTB)-Asn-Ala-Ser-OMe were 2.1 mM and 0.66 micromol/min/mg, respectively. A natural glycodipeptide, Man9-GlcNAc2-Asn-Phe, was also completely hydrolyzed by glycoamidase A.
Measurement and modelling of surface micromachined, electrostatically actuated microswitches (2002)

Electrostatically actuated micromechanical switches have been reported in earlier work by the authors. In the present work, a simple contact resistance model of the microswitch is discussed. Preliminary contact resistance measurements are presented, and compared with the modeled contact resistance characteristics.
Housekeeping gene selection for real-time RT-PCR normalization in potato during biotic and abiotic stress (2005)

Plant stress studies are more and more based on gene expression. The analysis of gene expression requires sensitive, precise, and reproducible measurements for specific mRNA sequences. Real-time RT-PCR is at present the most sensitive method for the detection of low abundance mRNA. To avoid bias, real-time RT-PCR is referred to one or several internal control genes, which should not fluctuate during treatments. Here, the non-regulation of seven housekeeping genes (beta-tubulin, cyclophilin, actin, elongation factor 1-alpha (ef1alpha), 18S rRNA, adenine phosphoribosyl transferase (aprt), and cytoplasmic ribosomal protein L2) during biotic (late blight) and abiotic stresses (cold and salt stress) was tested on potato plants using geNorm software. Results from the three experimental conditions indicated that ef1alpha was the most stable among the seven tested. The expression of the other housekeeping genes tested varied upon stress. In parallel, a study of the variability of expression of hsp20.2, shown to be implicated in late blight stress, was realized. The relative quantification of the hsp20.2 gene varied according to the internal control and the number of internal controls used, thus highlighting the importance of the choice of internal controls in such experiments.
Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells (2003)

Endothelial progenitor cells (EPCs) were shown to be present in systemic circulation and cord blood. We investigated whether EPCs display specific properties compared with mature endothelial cells. Human cord blood CD34+ cells were isolated and adherent cells were amplified under endothelial conditions. Expression of specific markers identified them as endothelial cells, also called endothelial progenitor-derived cells (EPDCs). When compared to mature endothelial cells, human umbilical vein endothelial cells (HUVECs) and human bone marrow endothelial cells (HBMECs), endothelial markers, were expressed to the same extent except for KDR, which is expressed more in EPDCs. They display a higher proliferation potential. Functional studies demonstrated that EPDCs were more sensitive to angiogenic factors, which afford these cells greater protection against cell death compared with HUVECs. Moreover, EPDCs exhibit more hematopoietic supportive activity than HUVECs. Finally, studies in nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice demonstrated that human circulating EPCs are able to colonize a Matrigel plug. EPDCs display the morphology and phenotype of endothelial cells. Their functional features indicate, however, that although these cells have undergone some differentiation steps, they still have the properties of immature cells, suggesting greater tissue repair capabilities. Future use of in vitro amplified peripheral blood EPDCs may constitute a challenging strategy for cell therapy.
Restricted assembly of MHC class II molecules in transgenic mice. (1989)

Studies on cell lines transfected with MHC class II genes have revealed important limitations on the assembly of haplotype-mismatched A alpha:A beta complexes. These findings led to the speculation that pairing restrictions, if applied in a cell type-specific fashion, might be involved in various autoimmune phenomena. We have investigated pairing restrictions in vivo by analyzing transgenic mice that carry an Ak alpha chain, an Ak beta chain, or the Ak alpha:Ak beta complex on an H-2b or H-2s background. Our conclusion is that the assembly of haplotype-mismatched A alpha:A beta complexes is limited in vivo, and that this is equally true for all cell types examined, regardless of their role in the immune response.