gebhart/patrepeval huggingface dataset:
Isolation and partial characterization of a polypeptide belonging to apolipoprotein B from low-density lipoproteins of human plasma (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and partial characterization of a polypeptide belonging to apolipoprotein B from low-density lipoproteins of human plasmaSven Olof Olofsson, Kristina Bostroem, Ulf Svanberg, and Goeran BondjersCite this: Biochemistry 1980, 19, 6, 1059–1064Publication Date (Print):March 18, 1980Publication History Published online1 May 2002Published inissue 18 March 1980https://pubs.acs.org/doi/10.1021/bi00547a002https://doi.org/10.1021/bi00547a002research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Treating human cancers with heat shock protein-peptide complexes: the road ahead (2009)

Immunization of human subjects with HSP-peptide complexes derived from autologous tumors mediates substantial clinical benefit in subjects with relatively early stage disease, consistent with results seen in animal models of cancer, and with an immunological mechanism of action. Additional clinical studies are essential for further development of this personalized medicine.
Breaking the I/O Bottleneck at the National Radio Astronomy Observatory (NRAO) (1994)

Respiratory tract microbial communities in lung transplant recipients differ in structure and composition from healthy subjects. Outlier analysis can identify specific bacteria replicating in lung. These findings provide novel approaches to address the relationship between microbial communities and transplant outcome and aid in assessing lung infections.
Identification and characterization of an active soluble form of human CD38 in normal and pathological fluids (1996)

Human CD38 is a transmembrane glycoprotein involved in lymphocyte activation and adhesion to endothelium. The ectocellular domain of the molecule possesses properties of a bifunctional enzyme catalyzing both the synthesis from NAD+ and the hydrolysis of the calcium-releasing metabolite cyclic ADP-ribose (cADPR). Surface expression of CD38 (mCD38) is rapidly and almost completely down-modulated upon ligation by specific mAb in cells from different lineages. The data presented here also show that, in addition to the existence of a mCD38, a soluble form of CD38 (sCD38) is detectable in the cell culture supernatant of allo-activated T lymphocytes and of several tumor cell lines. sCD38 is also present in vivo and is assayable in normal (fetal serum and amniotic fluid) and pathological (serum and ascites from patients with multiple myeloma, and serum from patients with AIDS) biological fluids. Immunoaffinity chromatography, SDS-PAGE and Western blot analyses with mAb and polyclonal antibodies, along with metabolic labeling, yield a body of data concerning the structure of sCD38, which displays a M(r) of 39 kDa. Native sCD38 maintains the ability to inhibit the binding activity of different anti-CD38 mAb and still catalyzes the synthesis and the hydrolysis of cADPR at the same ratio observed with mCD38. Furthermore, cross-linking experiments indicate that the purified soluble molecule binds a 120 kDa molecule expressed by monocytoid cells and identified as a candidate ligand for human mCD38.
A Silkworm Larvae Plasma Test for Detecting Peptidoglycan in Cerebrospinal Fluid Is Useful for the Diagnosis of Bacterial Meningitis (2003)

The silkworm larvae plasma (SLP) test has been established based on a cascade reaction triggered by either peptidoglycan or (1, 3)-beta-D-glucan to produce melanin. We applied this test to the diagnosis of bacterial meningitis. Cerebrospinal fluid (CSF) obtained from patients with bacterial meningitis due to gram-positive bacteria, gram-negative bacteria, or fungi, showed positive reactions to the test. In contrast, CSF from patients with viral meningitis or noninfectious illnesses gave negative reactions. Therefore, this test seems to be useful for diagnosis of bacterial and fungal meningitis. When this test was used together with two types of limulus tests, an endotoxin-specific test, and a conventional test, meningitis was further characterized as gram-positive, gram-negative or fungal meningitis. The SLP test requires a computerized instrument for quantitative colorimetric measurement. A qualitative alternative of this test also can be accomplished by visually observing the darkening color. Thus, this method can be applied for simple and rapid diagnosis of meningitis.
Query clustering using user logs (2002)

Query clustering is a process used to discover frequently asked questions or most popular topics on a search engine. This process is crucial for search engines based on question-answering. Because of the short lengths of queries, approaches based on keywords are not suitable for query clustering. This paper describes a new query clustering method that makes use of user logs which allow us to identify the documents the users have selected for a query. The similarity between two queries may be deduced from the common documents the users selected for them. Our experiments show that a combination of both keywords and user logs is better than using either method alone.
A neuromodulation strategy for rational therapy of complex brain injury states (2000)

We review initial efforts at neuromodulation in the vegetative state and organize several aspects of recent studies of the underlying neurobiology of catastrophic brain injuries. An innovative strategy for patient and target selection for neuromodulation of impaired cognitive function is outlined. Scientific and ethical issues that will attend future efforts to appropriately risk-stratify patients and initiate interventions with therapeutic intent are considered.
Impact of CYP2D6 genotype on postoperative tramadol analgesia (2003)

Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM) in about 10% of the Caucasian population. This study investigates whether the PM genotype has an impact on the response to tramadol analgesia in postoperative patients. A prospective study design was used and 300 patients recovering from abdominal surgery were enrolled. After titration of an individual loading dose, patients could self-administer 1 ml bolus doses of the drug combination tramadol 20 mg/ml, dipyrone 200 mg/ml and metoclopramide 0.4 mg/ml via patient-controlled analgesia (PCA). Patients' genotype was analyzed considering the most prevalent PM associated CYP2D6 mutations using a real-time PCR and hybridization based genotyping method. Demographic data, surgery related variables, pain scores, analgesic consumption and need for rescue medication were compared between extensive metabolizers (EM) and PM. The primary outcome criterion 'response' was defined as responder or non-responder status by the need for rescue medication and patients' satisfaction at the final interview. Demographic and surgery related data were comparable between EM (n=241) and PM (n=30). The percentage of non-responders was significantly higher in the PM group (46.7%) compared with the EM group (21.6%; p=0.005). Tramadol loading dose amounted to 108.2+/-56.9 and 144.7+/-22.6 mg (p<0.001) in EM and PM, respectively. More patients displaying the PM genotype needed rescue medication in the recovery room and during PCA period than patients with at least one wild type allele (21.6 versus 43.3%, p=0.02). PM for CYP2D6 showed a lower response rate to postoperative tramadol analgesia than EM. Therefore, CYP2D6 genotype has an impact on analgesia with tramadol. Pharmacogenetics may explain some of the varying response to pain medication in postoperative patients.
The role of enzymes in modern detergency (1998)

Abstract Enzymes have effectively assisted the development and improvement of modern household and industrial detergents. The major classes of detergent enzymes—proteases, lipases, amylases, and cellulases—each provide specific benefits for application in laundry and automatic dishwashing. Historically, proteases were first to be used extensively in laundry detergents. In addition to raising the level of cleaning, they have also provided environmental benefits by reducing energy consumption through shorter washing times, lower washing temperatures, and reduced water consumption. Today proteases are joined by lipases and amylases in improving detergent efficacy especially for household laundering at lower temperatures and, in industrial cleaning operations, at lower pH levels. Cellulases contribute to overall fabric care by rejuvenating or maintaining the new appearance of washed garments. Enzymes are produced by fermentation technologies that utilize renewable resources.
Deep Learning Interference Cancellation in Wireless Networks (2020)

With the crowding of the electromagnetic spectrum and the shrinking cell size in wireless networks, crosstalk between base stations and users is a major problem. Although hand-crafted functional blocks and coding schemes are proven effective to guarantee reliable data transfer, currently deep learning-based approaches have drawn increasing attention in the communication system modeling. In this paper, we propose a Neural Network (NN) based signal processing technique that works with traditional DSP algorithms to overcome the interference problem in realtime. This technique doesn't require any feedback protocol between the receiver and transmitter which makes it very suitable for low-latency and high data-rate applications such as autonomy and augmented reality. While there has been recent work on the use of Reinforcement Learning (RL) in the control layer to manage and control the interference, our approach is novel in the sense that it introduces a neural network for signal processing at baseband data rate and in the physical layer. We demonstrate this "Deep Interference Cancellation" technique using a convolutional LSTM autoencoder. When applied to QAM-OFDM modulated data, the network produces significant improvement in the symbol error rate (SER). We further discuss the hardware implementation including latency, power consumption, memory requirements, and chip area.
An approach for secure time synchronization in wireless sensor network (2010)

Wireless sensor networks (WSN) have received a lot of attention recently due to their wide applications such as target tracking, environment monitoring, and scientific exploration in dangerous environments. Secure time synchronization is a key service for wireless sensor networks (WSN). Time synchronization protocol synchronizes local clocks of group nodes to a common clock. In group, some of the sensor nodes may be malicious, which may disrupt the normal operation of a sensor network. In this paper a novel secure pair-wise and group-wise approaches for synchronizing the nodes in non-malicious environment are proposed.
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. (1991)

The cytochrome b heavy chain (gp91-phox) is expressed exclusively in terminally differentiating myelomonocytic cells. The human gp91-phox gene spans approximately 30 kilobases, and is divided into 13 exons. A ubiquitous factor that is indistinguishable from the CCAAT-binding factor CP1 interacts in vitro with the distal gp91-phox promoter CCAAT box motif. CP1 binding is prevented, however, by a CCAAT displacement protein (CDP) that binds to the region surrounding the CCAAT box. CDP DNA-binding activity is found in nuclear extracts prepared from cells in which the endogenous gp91-phox gene is transcriptionally inactive, but is absent or reduced in expressing cells, consistent with CDP functioning as a repressor of gp91-phox transcription. Introduction of gp91-phox promoter/reporter constructs into nonexpressing cells yields significantly less expression than that produced by the parental reporter vector alone. The reduction in expression is relieved when the CDP/CP1-binding site is removed from the gp91-phox promoter, confirming that it is a target for repression. No derepression is observed if the CP1-binding site is selectively mutated. Derepression of expression exhibited upon deletion of the CDP/CP1-binding site suggests that, in addition to blocking the interaction of the CCAAT-binding factor with the gp91-phox promoter, CDP may also repress transcription mediated through a distinct cis-element(s). We propose that down-regulation of CDP DNA-binding activity is a necessary step in the induction of myelomonocytic-specific expression of the gp91-phox gene.
Ultrafast dynamics of inter- and intraband transitions in semiconductor nanocrystals: Implications for quantum-dot lasers (1999)

Application of femtosecond transient absorption in the visible and near-IR spectral ranges and time-resolved photoluminescence allows us to separate electron and hole relaxation paths and to map the structure of interband and intraband optical transitions in CdSe and CdS nanocrystals (NC's) with a wide range of surface properties. In contrast to electron relaxation, which is controlled by NC surface passivation, depopulation of hole quantized states is extremely fast (sub-ps-to-ps time scales) in all types samples, independent of NC surface treatment (including NC's overcoated with a ZnS layer). Our results suggest that ultrafast hole dynamics are not due to trapping at localized surface defects such as a vacancy, but rather arise from relaxation into intrinsic NC states or intrinsically unpassivated interface states.
Image-Based Localization Using LSTMs for Structured Feature Correlation (2017)

In this work we propose a new CNN+LSTM architecture for camera pose regression for indoor and outdoor scenes. CNNs allow us to learn suitable feature representations for localization that are robust against motion blur and illumination changes. We make use of LSTM units on the CNN output, which play the role of a structured dimensionality reduction on the feature vector, leading to drastic improvements in localization performance. We provide extensive quantitative comparison of CNN-based and SIFT-based localization methods, showing the weaknesses and strengths of each. Furthermore, we present a new large-scale indoor dataset with accurate ground truth from a laser scanner. Experimental results on both indoor and outdoor public datasets show our method outperforms existing deep architectures, and can localize images in hard conditions, e.g., in the presence of mostly textureless surfaces, where classic SIFT-based methods fail.
Vitamin A Derivatives as Treatment Options for Retinal Degenerative Diseases (2013)

The visual cycle is a sequential enzymatic reaction for vitamin A, all-trans-retinol, occurring in the outer layer of the human retina and is essential for the maintenance of vision. The central source of retinol is derived from dietary intake of both retinol and pro-vitamin A carotenoids. A series of enzymatic reactions, located in both the photoreceptor outer segment and the retinal pigment epithelium, transform retinol into the visual chromophore 11-cis-retinal, regenerating visual pigments. Retina specific proteins carry out the majority of the visual cycle, and any significant interruption in this sequence of reactions is capable of causing varying degrees of blindness. Among these important proteins are Lecithin:retinol acyltransferase (LRAT) and retinal pigment epithelium-specific 65-kDa protein (RPE65) known to be responsible for esterification of retinol to all-trans-retinyl esters and isomerization of these esters to 11-cis-retinal, respectively. Deleterious mutations in these genes are identified in human retinal diseases that cause blindness, such as Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). Herein, we discuss the pathology of 11-cis-retinal deficiency caused by these mutations in both animal disease models and human patients. We also review novel therapeutic strategies employing artificial visual chromophore 9-cis-retinoids which have been employed in clinical trials involving LCA patients.
Steroid Hormones, Receptors, and Antagonists (1996)

In the thirty-odd years since the first demonstration of estrogen-binding components in reproductive tissues, much has been learned about the molecular details of steroid hormone action. Facts still to be elucidated include the precise mechanism by which interaction with the steroid disrupts the native receptor complex to generate an active transcription factor, just how this activated receptor enhances expression of target genes, and the role of phosphorylation in these events. The concept of receptor-medicated steroid hormone action has provided useful methods for predicting the risk of metastatic recurrence of breast cancers and the response of disseminated disease to endocrine therapy. Application of immunochemical techniques for receptor assay and elucidation of the role of mutant receptors in hormone resistance promise to increase the utility of these diagnostic procedures. A better understanding of the molecular details of steroid hormone antagonism should be helpful in the search for new and more effective agents for the endocrine control of breast cancers.
Fluoroolefins. VI.1 The Synthesis of Some α-Trifluoromethylstyrenes (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluoroolefins. VI.1 The Synthesis of Some α-TrifluoromethylstyrenesPAUL TARRANT and ROBERT EDWARD TAYLORCite this: J. Org. Chem. 1959, 24, 2, 238–239Publication Date (Print):February 1, 1959Publication History Published online1 May 2002Published inissue 1 February 1959https://pubs.acs.org/doi/10.1021/jo01084a022https://doi.org/10.1021/jo01084a022research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparative Study of Some Fiber-Optic Remote Raman Probe Designs. Part II: Tests of Single-Fiber, Lensed, and Flat- and Bevel-Tip Multi-Fiber Probes (1996)

We compare relative performances of flat-tipped, beveled (two-fiber and six-around-one), and single-lensed focused fiber-optic Raman probes and, where feasible, evaluate the utility of optical filters for reducing fiber background. The sensitivity profile of each probe is determined by measuring the relative intensity of light backscattered off a flat surface as a function of distance from the probe tip. The experimental results are compared with a simple light-cone-overlap model incorporating fiber numerical aperture, fiber and immersion medium refractive indices, separation between excitation and collection fibers, number of fibers, and fiber bevel angle and/or lens focal length. The model and sensitivity profiles are used to interpret the sampling regions for Raman spectra obtained by using each of the probes with a clear, transparent sample (single-crystal sparry calcite), a white, partially transparent sample (acetaminophen tablet), and a set of organic liquids of varying refractive index. The sensitivity of the tested commercial lensed probe drops off symmetrically about the focal point. For both solid samples, the intensity of fiber background follows a profile determined primarily by laser backscattering off the surface, whereas the sample Raman signal follows a profile dependent upon sampling depth.
Tritiated peptides. Part 15. Synthesis of tritium labelled biologically active analogues of somatostatin (1986)

The syntheses are described of cyclo-{[D-Trp8,Gaba12]somatostatin-(5–12)-peptide}(77), and (79)–(82) labelled singly at positions 6, 7, 8, and 11 and doubly at residues 6 and 11 to specific radioactivities of between 4.8 and 22.4 Ci mmol–1. The linear sequence (5–12) and the related cyclo-{[D-Trp8,Nag12]somatostatin-(5–12)-peptide}(78) and (83) were also prepared to specific radioactivities of 19.2 and 19.6 Ci mmol–1 respectively. The syntheses of the labelled hexapeptide cyclo-{[4-3H-Phe7,D-Trp8,Pro12] somatostatin-(7–12)-peptide}(84) and the full sequences [4-3H-Phe6,D- Trp8,D-Cys14]somatostatin (94) and [D-Trp8,4-3H-Phe11,D-Cys14]somatostatin (95) labelled at ca. 13.0 Ci mmol–1 are described. Labelling was effected by reductive dehalogenation in the presence of tritium of the fully protected precursors and the purity of the final products was assessed by amino acid analysis after acidic hydrolysis following purification by ion-exchange and h.p.l.c. as appropriate.
??-hydroxy-??-methylbutyrate ingestion, Part I: effects on strength and fat free mass (2000)

Although the IRM strength gains were not significantly different, HMB supplementation appears to increase peak isometric and various isokinetic torque values, and increase FFM and decrease plasma CPK activity. Lastly, it appears that higher doses of HMB (i.e., > 38 mg x kg(-1) x d(-1)) do not promote strength or FFM gains.
Stereoselective α-Sialylation with Sialyl Xanthate and Phenylsulfenyl Triflate as a Promotor (1996)

Reaction alpha- and beta-xanthates 2 and 3 of sialic acid with glycosyl acceptors 5-8 in the presence phenylsulfenyl triflate (PST) as a promotor in a 2:1 mixture of CH(3)CN/CH(2)Cl(2) at low temperature affords alpha-sialosides in good yield and stereoselectivity. PST is prepared in situ by reacting benzenesulfenyl chloride with silver triflate. Less reactive acceptors 5 and 6 give a higher alpha/beta ratio than more reactive allylic alcohol 7 and primary alcohol 8; alpha-stereoselectivity is increased in a dilute solution. A possible mechanism of the reaction that involves intermediate alpha- and beta-nitrilium cations 16 and 17 is discussed.