gebhart/patrepeval huggingface dataset:
Designing behaviors for information agents (1997)

Article Free Access Share on Designing behaviors for information agents Authors: Keith Decker Computer and Information Sciences, University of Delaware Computer and Information Sciences, University of DelawareView Profile , Anandeep Pannu The Robotics Institute, Carnegie-Mellon University The Robotics Institute, Carnegie-Mellon UniversityView Profile , Katia Sycara The Robotics Institute, Carnegie-Mellon University The Robotics Institute, Carnegie-Mellon UniversityView Profile , Mike Williamson The Robotics Institute, Carnegie-Mellon University The Robotics Institute, Carnegie-Mellon UniversityView Profile Authors Info & Claims AGENTS '97: Proceedings of the first international conference on Autonomous agentsFebruary 1997 Pages 404–412https://doi.org/10.1145/267658.267748Online:08 February 1997Publication History 64citation278DownloadsMetricsTotal Citations64Total Downloads278Last 12 Months12Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
No association of GSK3β gene (GSK3B) with Japanese schizophrenia (2005)

Several lines of evidence indicate that glycogen synthase kinase-3beta (GSK3beta) is one of the candidates for schizophrenia-susceptibility factor. However, it has not been reported the association analysis between GSK3beta gene (GSK3B) and Japanese schizophrenia based on linkage disequilibrium (LD). We provide an association analysis using relatively large samples (381 schizophrenia, and 352 controls) after determination of "tag single nucleotide polymorphisms (SNPs)." In this LD mapping, we selected and genotyped for eight polymorphisms (seven SNPs and one diallelic (CAA)(n) repeat), which covered the entire region of GSK3B, and determined two "tag SNPs." In the following association analysis using these two "tag SNPs," we could not find association with Japanese schizophrenia. Furthermore, we also include subgroup analysis considering age-at-onset and subtypes, neither could we find associations. Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia.
Unmyristylated Moloney murine leukemia virus Pr65gag is excluded from virus assembly and maturation events (1989)

The gag precursor polyprotein of Moloney murine leukemia virus (MuLV) is normally modified by myristylation of the N-terminal glycine. Previous work showed that the Pr65gag lacking the myristylation site does not associate with cellular membranes or assemble into virus particles. We now report that it also is not cleaved to the mature gag cleavage products within the cell and that it sediments as a free 65-kilodalton monomer in detergent-free cell extracts containing 0.3 M NaCl. Even when the cells containing the mutant are productively infected with wild-type MuLV, the mutant Pr65gag is not processed into cleavage products and is not incorporated into the virions produced by these cells. Thus, the mutant gag molecules seem unable to participate in the normal processes of self-assembly and maturation. We propose that myristate-mediated membrane association is an essential first step in MuLV assembly. This association may also play a role in budding of MuLV.
Platelet storage results in a redistribution of glycoprotein Ib molecules. Evidence for a large intraplatelet pool of glycoprotein Ib. (1988)

Platelet membrane glycoprotein (GP) Ib contains receptor for von Willebrand factor and thrombin. Its proteolytic fragment, glycocalicin, circulates in normal plasma. In this study, storage of platelet concentrates for 5 d resulted in a 221% increase in plasma glycocalicin (1.3 times the total amount of glycocalicin present on the surface of all platelets), an 8% overall increase in platelet surface GPIb, and the appearance of a surface GPIb-negative subpopulation of platelets. Total platelet GPIb content of fresh washed platelets, determined by gel electrophoresis and immunoassay of Triton X-100 lysates, averaged 159,740 molecules per platelet. There were 36,360 surface GPIb molecules per platelet, determined by immunoassay of the supernatant of fresh washed platelets whose surface GPIb had been completely plasmin-cleaved. In summary, these studies provide evidence for (a) a redistribution of GPIb molecules with platelet storage, and (b) a large intraplatelet pool of GPIb (approximately threefold larger than the platelet surface pool of GPIb).
Versatile Chain Transfer Agents for Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization to Synthesize Functional Polymeric Architectures (2004)

We report the syntheses and uses of versatile chain transfer agents (CTAs) that produce well-controlled macromolecular architectures with specific chain-end functionalities, via reversible addition fragmentation chain transfer (RAFT) polymerization). Examples of architectures are given, including amphiphilic copolymers and block copolymers incorporating a biodegradable block. These CTAs are also used for the grafting of poly(styrene), poly(methyl methacrylate) and poly(methyl acrylate) from cotton.
Broadcasting Internet Datagrams (1984)

This RFC proposes simple rules for broadcasting Internet datagrams on
local networks that support broadcast, for addressing broadcasts, and
for how gateways should handle them. This RFC suggests a proposed
protocol for the ARPA-Internet community, and requests discussion and
suggestions for improvements.
Introduction to the Principles of Ceramic Processing (1988)

Introduction to Principles of Ceramic Processing is an undergraduate text book for an introductory course in ceramic engineering. Covering how products are formed from natural and synthetic minerals, techniques of heat treatment, and their inherent characteristics, the book introduces the student and engineer to ceramics such as glass, porcelain, enamels, abrasives and refractories. A systematic development of the scientific principles involved in ceramic processing is presented, together with an explanation of principles such as packing, mixing, separation, granulation, forming, molding, casting, drying etc. The book also explains causes and prevention of product defects, and offers detailed explanations of material characterization and materials specifications, functions and nature of additives.
CD4+ AND B LYMPHOCYTES IN TRANSPLANTATION IMMUNITY (1993)

To test the importance of B lymphocytes in immunity to major histocompatibility complex class I alloantigens, B cell-deficient mice were generated by reconstituting severe combined immunodeficiency mice, which lack functional B and T lymphocytes, with T cells or with both T and B cells. The reconstituted mice were challenged with a cancer that expresses an MHC class I alloantigen at a low level and is susceptible to killing by CD8+ cytotoxic T lymphocytes. Tumors grew more slowly in and were rejected more frequently by the mice lacking B cells. Understanding the mechanism by which B cells suppress tumor allograft rejection may lead to new approaches for suppressing immune attack on transplanted tissues.
Antigen presentation by cisplatin‐activated macrophages: Role of soluble factor(s) and second messengers (1998)

Cisplatin [cis-dichlorodiammine platinum (II)], a potent anti-tumour compound, stimulates immune responses by activating macrophages and other cells of the immune system. The mechanism by which cisplatin activates these cells is poorly characterized. Present investigations were undertaken to study the mechanism of antigen presentation by cisplatin-treated macrophages. Cisplatin-treated macrophages showed a biphasic pattern of antigen presentation to keyhole limpet haemocyanin (KLH)-primed T cells. The second phase of antigen presentation was not due to the continuous presence of cisplatin in the culture medium; rather, it was induced by soluble factors released by cisplatin-treated macrophages. Co-incubation of macrophages with cisplatin and inhibitor of serine/threonine or protein tyrosine phosphatase resulted in an augmentation of cisplatin-induced antigen presentation. In contrast, treatment of macrophages with cisplatin and inhibitor of protein kinase C or protein tyrosine kinase inhibited cisplatin-induced antigen presentation. These observations suggest that antigen presentation by cisplatin-treated macrophages is regulated by reversible action of protein phosphatases and kinases. The antigen-presenting ability of cisplatin-treated macrophages was also inhibited by EGTA, nifedipine, TMB-8, W-7 and calmidazolium, suggesting the probable involvement of Ca2+, calmodulin and calmodulin-dependent kinases in this process.
MEDICAL NUTRITION FOR NON SPECIFIC ULCERATIVE COLITIS AND CROHN'S DISEASE IN CHILDREN (2008)

Disturbances of nutritive status are typical of patients with non specific ulcerative colitis и crohn's disease with such symptoms as body weight deficiency, disturbance of metabolism associated with the lack of proteins, macro and microelements, energy substrata. Nutrition plays a key role not only in the growth and development processes but also is one of the crucial factors determining the adequacy of the inflammatory response, adaptation compensatory processes. The article considers issues of medicated nutrition under this pathology, including the basic diet, usage of specialized mixes and enteral feeding to correct the protein energy disturbances, and as an independent treatment method.Key words: crohn's disease, non-specific ulcerative colitis, children, diet, enteral feeding, bowel disease.
Small-Molecule Switches for Zinc Finger Transcription Factors (2002)

We have developed a general approach to generate selective small-molecule switches for zinc finger transcription factors based on the notion of structural complementation. A small molecule, 2-(4'-quinoline)benzimidazole (7), was identified by screening of a heterocycle library, which functionally rescues a structurally compromised transcription factor C7-F116A/H125G-VP16. Compound 7 induces the activity of the mutant zinc finger in a luciferase-based transactivation assay by about 18-fold at 100 muM concentration. Surface plasmon resonance measurements revealed that compound 7 enhances the affinity between the mutant C7 and its cognate DNA sequence by 16-fold while a structurally analogous compound, 2-(2'-naphthyl)benzimidazole (8), showed no affinity enhancement, indicating there is a specific interaction between compound 7 and the mutant zinc finger. Taken together, these results suggest that the partial affinity recovery of the mutant transcription factor may be the mechanism for the functional rescue of the zinc finger transcription factor by compound 7.
Preparation of (S)-(-)-4-methyl-2-cyclohexen-1-one. A useful chiral building block (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of (S)-(-)-4-methyl-2-cyclohexen-1-one. A useful chiral building blockDuy H. Hua and S. VenkataramanCite this: J. Org. Chem. 1988, 53, 5, 1095–1097Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/jo00240a033https://doi.org/10.1021/jo00240a033research-articleACS PublicationsRequest reuse permissionsArticle Views763Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Signatures and software find high impedance faults (1995)

The detection of high-impedance faults on electrical distribution systems has been one of the most persistent and difficult problems facing the electric utility industry. High-impedance faults result from the unwanted contact of a primary circuit conductor with objects or surfaces that limit the current to levels below the detection thresholds of conventional protection devices. The author describes how recent advances in digital technology have enabled a practical solution for the detection of a high percentage of these previously undetectable faults.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Class of 2,4-Bisanilinopyrimidine Aurora A Inhibitors with Unusually High Selectivity against Aurora B (2009)

The two major Aurora kinases carry out critical functions at distinct mitotic stages. Selective inhibitors of these kinases, as well as pan-Aurora inhibitors, show antitumor efficacy and are now under clinical investigation. However, the ATP-binding sites of Aurora A and Aurora B are virtually identical, and the structural basis for selective inhibition has therefore not been clear. We report here a class of bisanilinopyrimidine Aurora A inhibitors with excellent selectivity for Aurora A over Aurora B, both in enzymatic assays and in cellular phenotypic assays. Crystal structures of two of the inhibitors in complex with Aurora A implicate a single amino acid difference in Aurora B as responsible for poor inhibitory activity against this enzyme. Mutation of this residue in Aurora B (E161T) or Aurora A (T217E) is sufficient to swap the inhibition profile, suggesting that this difference might be exploited more generally to achieve high selectivity for Aurora A.
New Methods for Immediate Revocation (1989)

This paper examines the need for immediate revocation, and then shows two new algorithms for implementing revocation that are much simpler and more efficient than existing algorithms. The two algorithms are appropriate for shared and unshared page tables, respectively, and can be used for both access control list and capability-based systems.
Multimedia clinical simulation based on patient records: authoring, user interface, pedagogy. (1994)

As an alternative to available computer-based clinical simulations that mimic patient encounters, we developed a clinical case simulation that more closely resembles the patient record. Our system, implemented in a Macintosh program called Short Rounds, features rapid and customized case authoring by editing a structured text file, a dynamic user interface that presents a case-specific screen layout, and a pedagogical model that is suitable for teaching third-year medical students. We believe this approach allows faculty members to create multimedia case simulations in shorter periods of time than in available clinical simulations.
Characterisation of wild‐type and mutant forms of human monoamine oxidase A and B expressed in a mammalian cell line (1993)

Monoamine oxidase (MAO)-A and MAO-B are FAD-containing mitochondrial enzymes which catabolize biogenic and xenobiotic amines. The N-terminal regions of both forms of MAO contain an ADP-binding consensus sequence found in several dinucleotide-dependent enzymes, but otherwise show remarkable sequence differences. In order to investigate whether the N-terminal region of MAOs participates in the different catalytic properties and inhibitor specificities exhibited by MAO-A and MAO-B, we constructed chimeric A/B forms and expressed them in a human embryonic kidney cell line (293 cells). The MAO-A chimeric form containing the N-terminus (36 amino acids) of MAO-B and the B chimera having the first 45 amino acid sequence of MAO-A were both catalytically active. Compared to the respective wild-type form, they did not show any significant difference in their catalytic properties (Km, kcat) towards the substrates tested or in their sensitivity towards inhibitors. This indicates that the N-terminal region of the two isoenzymes is not involved in the different specificities of MAO-A and MAO-B. Substitution of Cys-397 of MAO-B, i.e. the residue covalently anchoring FAD, with an Ala or a His residue resulted in the total loss of enzymatic activity, suggesting that the covalent coupling of FAD to MAO occurs specifically at the-SH group of cysteine.
Cytokine transcriptional events during helper T cell subset differentiation. (1996)

The molecular basis for changes in cytokine expression during T helper (Th) cell subset differentiation is not well understood. We have characterized transcriptional events related to cytokine gene expression in populations of naive T cell receptor-transgenic T cells as they are driven in vitro toward Th1 or Th2 phenotypes by interleukin (IL)-12 or IL-4 treatment, respectively. Quantitative reverse transcriptase-polymerase chain reaction analysis of cytokine transcripts indicates that interferon (IFN) gamma, IL-4, and IL-2 mRNA are expressed with distinct kinetics after naive T cells are stimulated with antigen and either IL-4 or IL-12. IFN-gamma mRNA appears as early as 6 h in IL-12-treated cultures, IL-4 appears only after 48 h in IL-4-treated cultures, and IL-2 is equivalently expressed in both types of cultures. Analyses were performed to determine if there were any differences in activation of IL-2 or IL-4 transcription factors that accompanied Th1 versus Th2 differentiation. These studies demonstrated that signal transducer and activator of transcription 6 (STAT6) binds to a sequence in the IL-4 promoter and that this STAT6-binding site can support IL-4-dependent transcription of a linked heterologous promoter. Prolonged activation of STAT6 is characteristic of populations undergoing Th2 differentiation. Furthermore, STAT6 is activated in an autocrine manner when differentiated Th2 populations are stimulated by antigen receptor ligation. Th1 populations derived from IL-12 plus antigen treatment of naive T cells remain responsive to IL-4 as indicated by induction of STAT6 and IL-4 mRNA. These data indicate that Th1 and Th2 differentiation represents the combination of different, apparently independently regulated transcriptional events. Furthermore, among transcription factors that bind to the IL-4 or IL-2 promoters, STAT6 is the one whose activation distinguishes Th2 versus Th1 development.
CDC25 Phosphatases as Potential Human Oncogenes (1995)

Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RASG12V or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.
Human Cell Culture Protocols (1996)

Expert scientific and clinical investigators present proven human cell culture techniques applicable to tissue samples taken from a wide variety of organs, particularly those prone to pathological cha
Bi-color and dual-band HgCdTe infrared focal plane arrays at Defir (2006)

The purpose of this paper is to present the latest developments in Defir (LETI / Sofradir joint laboratory) in the field of bi-color and dual band infrared focal plane arrays (FPA) made with HgCdTe. The npn structure is achieved using the Molecular Beam Epitaxy (MBE) technique, planar ion implantation, and both dry and wet etching steps. This back to back diode architecture that allows a perfect spatial coherence with a high field factor and large quantum efficiencies needs only one indium bump connection per pixel. This makes it possible to achieve small pitches (below 25&#956;m) and opens the way to the fabrication of large FPAs (TV/4 to TV) with reasonable wafer sizes. In this paper we present electro optical characterizations of 256x256 prototypes fabricated in Defir operating in two MWIR bands (3.1 and 5&#956;m) with a pitch of 25&#956;m that exhibit background limited performances together with a very high operability (above 99.9%) and NEDT below 22mK for integration time of only 0.5ms. In parallel an industrial product soon available from Sofradir has been developed with a 320x256 format and with a 30&#956;m pitch operating in the same bands. This product exhibits the same operability and NETD as low as 15mK for an integration time as short as 1 ms. Finally, last results regarding 256x256 prototypes operating in MWIR/LWIR bands are presented, together with preliminary APD operating mode for the MWIR photodiodes of this last dual band detector.
Bacteriostatic Saline Containing Benzyl Alcohol Decreases the Pain Associated with the Injection of Propofol (2005)

Bacteriostatic saline is a physiological saline solution containing the bacteriostatic agent benzyl alcohol as a 0.9% solution. It is used mostly for diluting and dissolving drugs for IV injection and as a flush for intravascular catheters. It also has local anesthetic properties. We studied its efficacy in decreasing the pain associated with IV administration of propofol and compared it with mixing lidocaine with propofol. One-hundred-twenty patients were randomly allocated into three groups. All patients received propofol 50 mg. The benzyl alcohol group received bacteriostatic saline as a preinjection, and the lidocaine group received propofol containing lidocaine. The placebo group did not receive bacteriostatic saline or lidocaine. Fifteen of 39 patients (38%) in the benzyl alcohol group complained of pain on injection compared to 33 of 39 (84%) in the placebo group and 22 of 42 (52%) in the lidocaine group. Differences were significant between the benzyl alcohol and placebo groups (P < 0.01) and the lidocaine and placebo groups (P < 0.01). Preinjection with bacteriostatic saline decreases the incidence of pain associated with IV administration of propofol and is comparable to that of mixing lidocaine with propofol.
Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer. (1995)

Prostatic carcinoma from 65 patients have been examined for the occurrence of point mutations in the p53 tumor suppressor gene locus within the region of exons 5 to 8. Overall, only a small fraction of tumors (12.3%) was found to contain p53 mutations. No significant correlation was detected between the presence of the mutant gene and either tumor volume or histopathological grade. However, metastatic prostatic tumors are found to display a higher percentage (21.4%) of p53 mutations compared with primary adenocarcinomas (9.8%). Analysis of the topographical distribution of the p53 mutant genotype revealed two remarkable findings. First, multifocal tumors within a prostate appear to differ in harboring the mutant gene, and second, evidence is obtained for intratumor heterogeneity in the distribution of the mutant p53 allele. Together these findings appear to explain, at least in part, why there has been a wide discrepancy in the reported detection frequency of p53 mutations in prostate cancer specimens. It appears that the outcome of mutation analysis would depend not only on which tumors but also which regions of the tumors are included in the study. Furthermore, the observed heterogeneous topographical distribution of the mutation, if confirmed to be unique to prostate cancer, may have important implications in the understanding of the biology of prostate carcinogenesis.