gebhart/patrepeval huggingface dataset:
Renal hemodynamics, function, and oxygenation during cardiac surgery performed on cardiopulmonary bypass: a modeling study (2015)

Acute kidney injury, a prevalent complication of cardiac surgery performed on cardiopulmonary bypass (CPB), is thought to be driven partly by hypoxic damage in the renal medulla. To determine the causes of medullary hypoxia during CPB, we modeled its impact on renal hemodynamics and function, and thus oxygen delivery and consumption in the renal medulla. The model incorporates autoregulation of renal blood flow and glomerular filtration rate and the utilization of oxygen for tubular transport. The model predicts that renal medullary oxygen delivery and consumption are reduced by a similar magnitude during the hypothermic (down to 28°C) phase of CPB. Thus, the fractional extraction of oxygen in the medulla, an index of hypoxia, is increased only by 58% from baseline. However, during the rewarming phase (up to 37°C), oxygen consumption by the medullary thick ascending limb increases 2.3-fold but medullary oxygen delivery increases only by 33%. Consequently, the fractional extraction of oxygen in the medulla is increased 2.7-fold from baseline. Thus, the renal medulla is particularly susceptible to hypoxia during the rewarming phase of CPB. Furthermore, autoregulation of both renal blood flow and glomerular filtration rate is blunted during CPB by the combined effects of hemodilution and nonpulsatile blood flow. Thus, renal hypoxia can be markedly exacerbated if arterial pressure falls below its target level of 50 mmHg. Our findings suggest that tight control of arterial pressure, and thus renal oxygen delivery, may be critical in the prevention of acute kidney injury associated with cardiac surgery performed on CPB.
胖嘟嘟的风雨兰——Lily Pies (2016)

有一天，偶然被网上一种植物的开花美图深深吸引。它美得有点不真实，像假花一样娇嫩可爱。它就是一款风雨兰，拉丁名为Zephyranthes’LilyPies’。’LilyPies’株高15～30厘米，叶子像韭菜，夏季开花，白中带粉的花瓣柔美羞涩，又胖嘟嘟地清润丰腴，所以花友们喜欢称它“胖丽丽”或“丽丽派”。
Influence of different signal peptides and prosequences on expression and secretion of human tissue plasminogen activator in the baculovirus system (1993)

Foreign secretory pathway proteins are often produced in surprisingly low amounts in the baculovirus/insect cell expression system. One possible reason for this is that heterologous signal peptides might be inefficiently recognized by the insect cell protein translocation machinery. This idea was supported by a recent study showing that secretion of a plant protein in the baculovirus system was enhanced when its signal peptide was replaced with an insect-derived signal peptide (Tessier, D. C., Thomas, D. Y., Khouri, H. E., Laliberte, F., and Vernet, T. (1991) Gene (Amst.) 98, 177-183). We have extended these observations by measuring the effects of different signal peptide and signal peptide-prosequence combinations on baculovirus-mediated expression and secretion of human tissue plasminogen activator (t-PA). Replacement of the native prepropeptide with signal peptides from a lepidopteran insect secretory protein (cecropin B), a major baculovirus structural glycoprotein (64K), or an abundant, highly conserved lumenal protein of the rough endoplasmic reticulum (GRP78/BiP, a 78-kDa glucose-regulated protein/immunoglobulin heavy chain-binding protein), had no significant effect on t-PA expression or secretion. The same results were obtained with the signal peptide from honeybee prepromellitin, which was able to enhance secretion of plant propapain (Tessier et al., 1991 (above)). Similar results were obtained when heterologous signal peptides were combined with the native prosequence or when the intact cecropin B preprosequence was used. Translational initiation at an upstream, in-frame ATT, which could functionally inactivate any signal peptide, did not explain the low efficiency of t-PA secretion. Finally, deletion of the native signal peptide, prosequence, or both, failed to increase t-PA production. These results showed that insect-derived signal peptides and/or prosequences cannot always enhance the expression and/or secretion of foreign secretory pathway proteins in the baculovirus system. They also suggested that the inability of insect cells to recognize the processing signals in human t-PA efficiently is probably not the major factor preventing its high level production in this system.
Intravenous versus intrastriatal cord blood administration in a rodent model of stroke (2003)

Human umbilical cord blood (hUCB) is a rich source of hematopoietic stem cells that have been used to reconstitute immune cells and blood lineages. Cells from another hematopoietic source, bone marrow, have been found to differentiate into neural cells and are effective in the treatment of stroke. In this study, we administered hUCB cells intravenously into the femoral vein or directly into the striatum and assessed which route of cell administration produced the greatest behavioral recovery in rats with permanent middle cerebral artery occlusion (MCAO). All animals were immunosuppressed with cyclosporine (CSA). When spontaneous activity was measured using the Digiscan automated system, it was found to be significantly less when hUCB was transplanted 24 hr after stroke compared with nontransplanted, stroked animals (P < 0.01). Furthermore, behavioral recovery was similar with both striatal and femoral hUCB delivery. This is in contrast to the step test, in which significant improvements were found only after femoral delivery of the hUCB cells. In the passive avoidance test, transplanted animals learned the task faster than nontransplanted animals (P < 0.05). Together, these results suggest that hUCB transplantation may be an effective treatment for brain injuries, such as stroke, or neurodegenerative disorders. In addition, intravenous delivery may be more effective than striatal delivery in producing long-term functional benefits to the stroked animal.
Convolutional Network for Attribute-driven and Identity-preserving Human Face Generation (2016)

This paper focuses on the problem of generating human face pictures from specific attributes. The existing CNN-based face generation models, however, either ignore the identity of the generated face or fail to preserve the identity of the reference face image. Here we address this problem from the view of optimization, and suggest an optimization model to generate human face with the given attributes while keeping the identity of the reference image. The attributes can be obtained from the attribute-guided image or by tuning the attribute features of the reference image. With the deep convolutional network "VGG-Face", the loss is defined on the convolutional feature maps. We then apply the gradient decent algorithm to solve this optimization problem. The results validate the effectiveness of our method for attribute driven and identity-preserving face generation.
Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry (2010)

Glucose is the main source of energy for the body, requiring constant regulation of its blood concentration. Insulin release by the pancreas induces glucose uptake by insulin-sensitive tissues, most notably the brain, skeletal muscle, and adipocytes. Patients suffering from type-2 diabetes and/or obesity often develop insulin resistance and are unable to control their glucose homeostasis. New insights into the mechanisms of insulin resistance may provide new treatment strategies for type-2 diabetes. The GLUT family of glucose transporters consists of thirteen members distributed on different tissues throughout the body. Glucose transporter type 4 (GLUT4) is the major transporter that mediates glucose uptake by insulin sensitive tissues, such as the skeletal muscle. Upon binding of insulin to its receptor, vesicles containing GLUT4 translocate from the cytoplasm to the plasma membrane, inducing glucose uptake. Reduced GLUT4 translocation is one of the causes of insulin resistance in type-2 diabetes. The translocation of GLUT4 from the cytoplasm to the plasma membrane can be visualized by immunocytochemistry, using fluorophore-conjugated GLUT4-specific antibodies. Here, we describe a technique to quantify total amounts of GLUT4 translocation to the plasma membrane of cells during a chosen duration, using flow cytometry. This protocol is rapid (less than 4 hours, including incubation with insulin) and allows the analysis of as few as 3,000 cells or as many as 1 million cells per condition in a single experiment. It relies on anti-GLUT4 antibodies directed to an external epitope of the transporter that bind to it as soon as it is exposed to the extracellular medium after translocation to the plasma membrane.
Ribosomal Ribonucleic Acid Cistron Similarities and Deoxyribonucleic Acid Homologies of Neisseria, Kingella, Eikenella, Simonsiella, Alysiella, and Centers for Disease Control Groups EF-4 and M-5 in the Emended Family Neisseriaceae (1989)

We detected distinct taxonomic relationships among the true Neisseria species, Kingella kingae, Kingella denitrificans, Eikenella corrodens, all Simonsiella species, the type strain of Alysiella filiformis, and members of Centers for Disease Control groups EF-4 and M-5. All these taxa constitute one large separate cluster having high levels of ribosomal ribonucleic acid cistron similarity (thermal dénaturation temperature range, 74 to 81°C) in ribosomal ribonucleic acid superfamily III. There are at least four subbranches. We found high deoxyribonucleic acid (DNA)-DNA homology values between Neisseria gonorrhoeae and some other true Neisseria species and within the following species: Simonsiella muelleri, Simonsiella crassa, Simonsiella steedae, Kingella denitrificans, and Eikenella corrodens. All of the members of this large cluster have genome base compositions in the range from 42.8 to 57.7 mol% guanine plus cytosine. The molecular complexities of the genomic DNAs are 2.2 x I09 to 2.7 × 109 for Simonsiella and Alysiella species and 1.4 × 109 to 1.8 × 109 for the other members of this large cluster. We formally propose that this large cluster represents the emended family Neisseriaceae containing the following genera and groups: Neisseria, Kingella (not the generically misnamed Kingella indologenes), Eikenella, Simonsiella, Alysiella (not some misnamed strains), and Centers for Disease Control groups EF-4 and M-5. The genera and subgenera Acinetobacter, Moraxella, Branhamella, Psychrobacter, the false neisseriae, and Kingella indologenes should be removed from the Neisseriaceae, as they belong to superfamilies I and II.
Processing of type I collagen gels using nonenzymatic glycation (2009)

This study focuses on the development of a novel method of nonenzymatic glycation of fibrillar collagen gels. In contrast to previous studies in which type I collagen gels were glycated in the solid state, this study presents a method for glycation in solution. The type I collagen in solution or gels was exposed to a range of ribose concentrations from 0 to 250 mM. The binding of ribose to collagen was documented using Fourier transform infrared (FTIR) spectroscopy. formation of advanced glycation end products (AGEs) was quantified by fluorescence measurement. The bulk compressive modulus and viscoelastic time constant of processed gels were determined in stress relaxation studies. Both methods of glycation enhanced ribose addition and AGE formation in a dose-dependent manner, with glycation in the gel state being more efficient. Both methods enhanced mechanical properties similarly, with 250 mM ribose treatment resulting in a 10-fold increase in bulk modulus.
Recovery of immune functions in dogs after total body irradiation and transplantation of autologous blood or bone marrow cells. (1985)

The restoration of immune functions was followed in dogs for 101 days after fractionated total body irradiation and autologous transfusion of peripheral blood leukocytes (PBL) or bone marrow (BM) cells. Median numbers of 0.9 X 10(5) granulocyte-macrophage progenitor cells per kilogram of body weight were transferred in either group of recipients. The following parameters recovered more rapidly in PBL recipients as opposed to BM recipients: total blood lymphocyte, T- and B-cell counts, serum levels of immunoglobulins IgM and IgA, in vitro blastogenic responses after stimulation with concanavalin A and pokeweed mitogen, and in vitro plasma cell formation after polyclonal B-cell activation with pokeweed mitogen with or without lipopolysaccharide. No major differences were noted for the restoration of serum IgG levels. Circulating lymphocyte and T-cell numbers remained subnormal for more than three months in both groups, whereas B-cell numbers and serum levels of IgA continued to be depressed in BM recipients only. Thus, autologous PBL restored immune functions more rapidly than did BM. Transplantation of PBL, alone or in addition to autologous BM, might also shorten the period of immunodeficiency after cytoreduction in a variety of malignancies in man.
Work sampling of product development activities (2016)

For effective management of development projects, it is necessary to take into consideration its socio-technical perspective – working processes, teamwork and features of the working environment. Data gathering about socio-technical aspects of the product development activities is often hampered by constraints of the actual working environment in R&amp;D organizations. For that reason, to support practical data collection, the work sampling application for mobile phones has been introduced. The work sampling application consists of sequence of input screens with predefined input menus enabling data gathering about different aspects of the product development activity (such as work type, activity type, context, participants, execution manner, information transaction and motivation). For validation of the proposed application, the empirical study was carried out in the company whose research and development activities are focused on the systems for the generation, distribution and transformation of electrical energy.
Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α (2014)

Trop-2 has limited presence on normal tissues but is highly expressed in diverse epithelial cancers. (E1)-3s is a T-cell-redirecting trivalent bispecific antibody (bsAb), comprising an anti-CD3 scFv covalently linked to a stabilized dimer of a Trop-2-targeting Fab using Dock-and-Lock. We show for the first time that bsAb-mediated bidirectional trogocytosis occurs between target and T cells and involves immunologic synapses. We studied the effects of interferon-α (INFα) on (E1)-3s-mediated T-cell killing of human gastric and pancreatic cancer cell lines. T-cell activation, cytokine induction, and cytotoxicity were evaluated ex vivo using peripheral blood mononuclear cells (PBMC) or T cells with NCI-N87 gastric cancer as target cells. In vivo activity was assayed with NCI-N87 and Capan-1 (pancreatic) xenografts. In the presence of target cells and PBMCs, (E1)-3s did not cause excess cytokine production. When combined with (E1)-3s, peginterferonalfa-2a--which alone did not increase T-cell activation or raise cytokine levels over baseline--increased CD69 expression but did not significantly increase cytokine induction. (E1) 3s mediated a highly potent T-cell lysis of NCI-N87 target cells in vitro. Inclusion of peginterferonalfa-2a or a more potent form of INFα, 20*-2b, significantly potentiated the activity of (E1)-3s by more than 2.5- or 7-fold, respectively. In vivo, combining peginterferonalfa-2a with (E1)-3s delayed Capan-1 growth longer than each single agent. Similarly, combination therapy delayed tumor proliferation of NCI-N87 compared with (E1)-3s or peginterferonalfa-2a single-treatment groups. (E1)-3s effectively induced T-cell-mediated killing of Trop-2-expressing pancreatic and gastric cancers, which was enhanced with INFα.
A Fixed-Complexity MIMO Detector Based on the Complex Sphere Decoder (2006)

A new detection algorithm for uncoded multiple input-multiple output (MIMO) systems based on the complex version of the sphere decoder (SD) is presented in this paper. The algorithm performs a fixed number of operations to detect the symbols, independent of the noise level. The algorithm achieves this by combining a novel channel matrix preprocessing with a search through a small subset of the complete receive constellation. Simulation results show it has only a very small bit error ratio (BER) degradation compared to the original SD while being suited for a fully-pipelined hardware implementation due to its fixed complexity
Phage Display in Molecular Imaging and Diagnosis of Cancer (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPhage Display in Molecular Imaging and Diagnosis of CancerSusan L. Deutscher*View Author Information Biochemistry Department, 117 Schweitzer Hall, University of Missouri, Columbia, Missouri 65211, and Harry S Truman Medical Veterans Hospital, Columbia, Missouri 65201* Tel: 573-882-2454. Fax: 573-882-5635. E-mail: [email protected]Cite this: Chem. Rev. 2010, 110, 5, 3196–3211Publication Date (Web):February 19, 2010Publication History Received16 September 2009Published online19 February 2010Published inissue 12 May 2010https://pubs.acs.org/doi/10.1021/cr900317fhttps://doi.org/10.1021/cr900317freview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views5398Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biological imaging,Cancer,Peptides and proteins,Tumors,Viruses Get e-Alerts
Instant dehazing of images using polarization (2005)

We present an approach to easily remove the effects of haze from images. It is based on the fact that usually airlight scattered by atmospheric particles is partially polarized. Polarization filtering alone cannot remove the haze effects, except in restricted situations. Our method, however, works under a wide range of atmospheric and viewing conditions. We analyze the image formation process, taking into account polarization effects of atmospheric scattering. We then invert the process to enable the removal of haze from images. The method can be used with as few as two images taken through a polarizer at different orientations. This method works instantly, without relying on changes of weather conditions. We present experimental results of complete dehazing in far from ideal conditions for polarization filtering. We obtain a great improvement of scene contrast and correction of color. As a by product, the method also yields a range (depth) map of the scene, and information about properties of the atmospheric particles.
Effect of Antimicrobial Therapy for Experimental Infections Due to Group B Streptococcus On Mortality and Clearance of Bacteria (1987)

In an effort to develop more effective antimicrobial therapy, we evaluated three alternative regimens currently available to clinicians for their efficacy against experimental bacteremia and meningitis due to group B Streptococcus (GBS) in newborn rats: various doses of penicillin G (100, 200, 400, or 800 mg/kg per day), combined penicillin G-gentamicin vs. penicillin G, and ceftriaxone vs. penicillin G. Higher doses of penicillin G and ceftriaxone exhibited significantly greater bactericidal activity in blood and cerebrospinal fluid (CSF), whereas the bactericidal activity of penicillin G plus gentamicin was not significantly different from that of penicillin G. Clearance of GBS from blood was significantly more rapid in animals receiving ceftriaxone. However, differences in death rates were not apparent with any single regimen. These findings suggest that clearance of GBS from blood and CSF can be improved by more potent antimicrobial agents, but further reduction in the death rate may be difficult to achieve by antimicrobial therapy alone.
The 1:1 adduct of 4-aminobenzoic acid with 4-aminobenzonitrile (2000)

The 1:1 adduct of 4-aminobenzoic acid (PABA) with 4-am-inobenzonitrile (PABN), C(7)H(7)NO(2).C(7)H(6)N(2), consists of a primary centrosymmetric cyclic hydrogen-bonded PABA dimer interaction [O.O 2.640 (3) A] peripherally linked into chains by weaker hydrogen bonds via a head-to-tail PABN interaction [N.N 3.179 (4) and N.O 3.062 (4) A], and is linked between the chains by amine-N (PABN) to amine-N (PABA) interactions [N.N 3.233 (5) A]. No proton transfer occurs.
Complications of Total Hip Arthroplasty Associated with the Use of an Acetabular Component with a Hylamer Liner* (1997)

We observed early failure and radiographic signs of accelerated wear as early as one to three years after insertion, without cement, of a metal-backed acetabular component with a liner made of Hylamer (DePuy). This finding prompted us to review a larger cohort of patients in whom that liner had been used. Two hundred and thirty-three components with a Hylamer liner, evaluated at a minimum of two years, had a mean rate of wear of 0.27 millimeter per year compared with 0.12 millimeter per year for a contemporaneous group of fifty acetabular cups with a conventional ultra-high molecular weight polyethylene liner made by another manufacturer. At a mean of 3.2 years, we found a significant difference (p < 0.000000006) between the mean rate of wear (0.20 millimeter per year) when the Hylamer liner articulated with a DePuy modular cobalt-chromium femoral head and the mean rate (0.29 millimeter per year) when the liner articulated with an Osteonics modular cobalt-chromium femoral head. Radiographic evaluation revealed a significant correlation between the total linear wear and the prevalence of osteolytic lesions (r2 = 0.76, linear regression analysis). We found that wear of 1.5 millimeters or more could be detected by the unaided eye. Because of the positive correlation between osteolysis and wear of 1.5 millimeters or more, we defined a hip with a liner that had that amount of wear as a hip at risk. We concluded that the wear characteristics of a Hylamer liner in vivo are inferior to those of a conventional ultra-high molecular weight polyethylene liner. Also, the rate of wear of the liner is greater when the femoral head is from a manufacturer other than DePuy. A patient who has a total hip replacement that includes a Hylamer liner should be monitored frequently for signs of wear and osteolytic changes. Additional investigations, with longer durations of follow-up and larger populations, are needed to understand fully the importance of our findings.
The Role of HLA A2 and Cw2 in the Pathogenesis of Human Demodicosis (2005)

The HLA A2 and Cw2 phenotypes have an important diagnostic, prognostic and pathogenetic significance and could play a role in resistance or susceptibility to demodicosis by regulating the end phase of the immune response.
Spatial light modulator technologies for WDM (1998)

This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk.