gebhart/patrepeval huggingface dataset:
Microstructures and Mechanical Properties of Ultra Low Carbon Interstitial Free Steel Severely Deformed by a Multi-Stack Accumulative Roll Bonding Process (2004)

An ultra low carbon interstitial free (IF) steel was severely deformed by the six-layer stack accumulative roll-bonding (ARB) process for improvement of the mechanical properties. As-received material with 1 mm in thickness showed a recrystallization structure with average grain diameter of 27 μm. The ARB was conducted at ambient temperature after deforming the as-received material to 0.5 mm thick by cold rolling. The ARB was performed for six-layer stacked, i.e. 3 mm thick sheet, up to 3 cycles (an equivalent strain of ∼7.1). In each ARB cycle, the stacked sheets were, first, deformed to 1.5 mm thick by the first pass, and then reduced to 0.5 mm thick, equals to the starting thickness, by multipass rolling without lubrication. The specimen after 3 cycles of ARB was annealed for 1.8 ks at various temperatures ranging from 673 K to 1073 K. The tensile strength of the ARB processed materials increased largely with the number of ARB cycles, after 3 cycles it reached a maximum of 1.12 GPa, which is about 4 times larger than that of the initial material. The elongation dropped largely after the cold rolling prior to the ARB, however it remains almost constant during the subsequent ARB process. Transmission Electron Microscopy revealed that the ARB processed materials exhibited a dislocation cell and/or subgrain structure with relatively high dislocation density. The selected area diffraction (SAD) patterns suggested that the orientation difference between neighboring cells was very small. The annealing up to 873 K resulted in gradual decrease in the strength due to the static recovery. The annealing above 873 K resulted in recrystallization and normal grain growth, and thereby a significant drop in the strength and recovery in ductility.
Definition of endotoxin binding sites in horseshoe crab Factor C recombinant sushi proteins and neutralization of endotoxin by sushi peptides (2000)

Three truncated fragments, harboring different sushi domains, namely, sushi123, sushi1, and sushi3 domains, of Factor C were produced as biologically active secreted recombinant proteins. Sushi1 and 3 each has a high-affinity LPS binding site with K:(d) of 10(-9) to 10(-10) M. Positive cooperativity in sushi123 resulted in a 1000-fold increase in K:(d)2. The core LPS binding region of sushi1 and 3 reside in two 34-mer peptides, S1 and S3. A rigidly held disulfide-bonded structure is not essential but is important for LPS binding, as confirmed by a 100- to 10000-fold decrease in affinity. Both S1 and S3 can inhibit LAL reaction and LPS-induced hTNF-alpha secretion with different potency. LAL assay revealed that at least two molecules of S1 bind cooperatively to one LPS molecule, with Hill's coefficient of 2.42. The LPS binding by S3 is independent and noncooperative. The modified SDelta1 and SDelta3 peptides exhibited increased LPS neutralization potential although its LPS binding affinities indicated only a 10-fold improvement. Hence, the structural difference of the four sushi peptides conferred different efficiencies in LPS neutralization without altering their binding affinity for LPS. Circular dichroism spectrometry revealed that the four peptides underwent conformational change in the presence of lipid A, transitioning from a random coil to either an alpha-helical or beta-sheet structure. Two factors are critical for the sensitivity of Factor C to LPS: 1) the presence of multiple binding sites for LPS on a single Factor C molecule; and 2) high positive cooperativity in LPS binding. The results showed that in the design of an improved LPS binding and neutralizing peptide, charge balance of the peptide is a critical parameter in addition to its structure.
Usefulness of DC power flow for active power flow analysis (2005)

In recent days almost every study concerning the analyses of power systems for market related purposes uses DC power flow. DC power flow is a simplification of a full power flow looking only at active power flows. Aspects as voltage support and reactive power management are not considered. However, such simplifications cannot always be justified and might sometimes be unrealistic. In this paper authors analyze the assumptions of DC power flow, and make an attempt at quantifying these using indexes. Among other, the paper answers the question of how low the X/R ratio of line parameters can be, and what is the maximal deviation from the perfect flat voltage which still allows DC power flow to be acceptably accurate.
From throw-away traffic to bots: detecting the rise of DGA-based malware (2012)

Many botnet detection systems employ a blacklist of known command and control (C&amp;amp;C) domains to detect bots and block their traffic. Similar to signature-based virus detection, such a botnet detection approach is static because the blacklist is updated only after running an external (and often manual) process of domain discovery. As a response, botmasters have begun employing domain generation algorithms (DGAs) to dynamically produce a large number of random domain names and select a small subset for actual C&amp;amp;C use. That is, a C&amp;amp;C domain is randomly generated and used for a very short period of time, thus rendering detection approaches that rely on static domain lists ineffective. Naturally, if we know how a domain generation algorithm works, we can generate the
Predictive value of clinical features for the obstructive sleep apnoea syndrome (1996)

The advantage of being a National Referral Centre for patients with suspected obstructive sleep apnoea (OSA) was used to seek clinical factors predictive of OSA, and thus determine if the number of polysomnography tests required could be reduced. Patients were mainly primary referrals, from an island population of 3.5 million. Two hundred and fifty consecutive patients underwent clinical assessment, full polysomnography, and a detailed self-administered questionnaire. This represents one of the largest European studies, so far, utilizing full polysomnography. Fifty four percent (n = 134) had polysomnographic evidence of OSA (apnoea/hypopnoea index (AHI) > or = 15 events.h-1 sleep). Patients with OSA were more likely to be male, and had a significantly greater prevalence of habitual snoring, sleeping supine, wakening with heartburn, and dozing whilst driving. Alcohol intake, age and body mass index (BMI) were significant independent correlates of AHI. After controlling for BMI and age, waist circumference correlated more closely with AHI than neck circumference among males, while the opposite was true among females. No single factor was usefully predictive of obstructive sleep apnoea. However, combining clinical features and oximetry data, where appropriate, approximately one third of patients could be confidently designated as having obstructive sleep apnoea or not. The remaining two thirds of patients would still require more detailed sleep studies, such as full polysomnography, to reach a confident diagnosis.
Gene Targeting in Human Pluripotent Cells (2010)

Mouse embryonic stem cells (mESCs) have the ability to differentiate into any cell type and can generate chimeric mice when transplanted into a host blastocyst. This remarkable potential, together with the development of robust gene targeting strategies in mESCs, were essential for establishing the mouse as the most widely used model organism in biomedical research. Recent advances have allowed the isolation of human embryonic stem cells and the derivation of induced pluripotent stem cells. Genetic tools similar to those proven routine in the mouse system are needed to realize the full potential of human pluripotent cells as disease models and putative therapeutics. Gene targeting in human cells, however, has proven to be more difficult, more time-consuming, and less robust than in mESCs. In this chapter, we discuss the strategies that have been used to allow specific genetic modifications in human pluripotent cells. We focus on the novel application of custom-engineered zinc-finger nucleases for gene targeting, which has promise to become a robust tool for efficient genetic manipulation of human pluripotent cells.
Cooking Procedure Recognition and Support by Ubiquitous Sensors (2009)

This paper proposes cooking support using ubiquitous sensors. We developed a machine learning algorithm that recognizes cooking procedures by taking into account widely varying sensor information and user behavior. To provide appropriate instructions to users, we developed a Markov-model-based behavior prediction algorithm. Using these algorithms, we developed cooking support automatically displaying cooking instruction videos based on user progress. Experiments and experimental results confirmed the feasibility of our proposed cooking support.
Antithrombotic Effect of Platelet Glycoprotein Ib–Blocking Monoclonal Antibody Fab Fragments in Nonhuman Primates (2000)

Platelet adhesion in arterial blood flow is mainly supported by the platelet receptor glycoprotein (GP) Ib, which interacts with von Willebrand factor (vWF) that is bound to collagen at the site of vessel wall injury. Antibody 6B4 is a monoclonal antibody (MoAb) raised against purified human GPIb. MoAb 6B4 inhibits both ristocetin- and botrocetin-induced, vWF-dependent human platelet agglutination. MoAb 6B4 furthermore blocks shear-induced adhesion of human platelets to collagen I. We studied the antithrombotic effect of this inhibitory murine MoAb 6B4 in a baboon model of arterial thrombosis. When injected into baboons, intact IgG and its F(ab')(2) fragments caused almost immediate thrombocytopenia, whereas injection of the Fab fragments alone did not. Fab fragments were subsequently used to investigate their in vivo effect on platelet deposition onto a thrombogenic device, consisting of collagen-rich, glutaraldehyde-fixed bovine pericardium (0.6 cm(2)), at a wall shear rate ranging from 700 to 1000 s(-1). Baboons were either pretreated with Fabs to study the effect of inhibition on platelet adhesion or treated 6 minutes after placement of the thrombogenic device to investigate the effect on interplatelet cohesion. Pretreatment of the animals with bolus doses ranging from 80 to 640 microgram/kg Fab fragments significantly reduced (111)In-labeled platelet deposition onto the collagen surface by approximately 43% to 65%. Only the highest dose caused a significant prolongation (doubling) of the bleeding time. Ex vivo ristocetin-induced platelet agglutination was equally reduced. Treatment with a bolus of 110 microgram/kg Fab fragments after a thrombus was allowed to form for 6 minutes had no effect on further platelet deposition. We therefore conclude that Fab fragments or derivatives of inhibitory anti-GPIb antibodies may be useful compounds to prevent thrombosis.
A Sub-10 nA DC-Balanced Adaptive Stimulator IC With Multi-Modal Sensor for Compact Electro-Acupuncture Stimulation (2012)

A compact electro-acupuncture (EA) system is proposed for a multi-modal feedback EA treatment. It is composed of a needle, a compact EA patch, and an interconnecting conductive thread. The 3 cm diameter compact EA patch is implemented with an adaptive stimulator IC and a small coin battery on the planar-fashionable circuit board (P-FCB) technology. The adaptive stimulator IC can form a closed current loop for even a single needle, and measure the electromyography (EMG) and the skin temperature to analyze the stimulation status as well as supply programmable stimulation current (40 μA-1 mA) with 5 different modes. The large time constant (LTC) sample and hold (S/H) current matching technique achieves the high-precision charge balancing ( <;10 nA) for the patient's safety. The measured data can be wirelessly transmitted to the external EA analyzer through the body channel communication (BCC) transceiver for the low power consumption. The external EA analyzer can show the patient's status, such as the muscle fatigue and the change of the skin temperature. Based on these analyses, the practitioner can adaptively change the stimulation parameters for the optimal treatment value. A 12.5 mm(2) 0.13 μm RF CMOS stimulator chip consumes 6.8 mW at 1.2 V supporting 32 different current levels. The proposed compact EA system is fully implemented and tested on the human body.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports (2012)

Article An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports was published on March 1, 2012 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 50, issue 3).
Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells (2006)

Regulatory T cells (Tregs) have been implicated as key players in immune tolerance as well as suppression of antitumor responses. The chemotherapeutic alkylating agent cyclophosphamide (CY) is widely used in the treatment of tumors and some autoimmune conditions. Although previous data has demonstrated that Tregs may be preferentially affected by CY, its relevance in promoting autoimmune conditions has not been addressed. The nonobese diabetic mouse spontaneously develops type-1 diabetes (T1D). We demonstrate in this study that CY targets CD4+CD25+Foxp3+ Tregs in vivo. CD4+CD25+ T cells isolated from CY-treated mice display reduced suppressive activity in vitro and increased expression of apoptotic markers. Although Treg numbers rapidly recovered to pretreatment levels in the peripheral lymphoid tissues, Tregs failed to recover proportionally within pancreatic infiltrates. T1D progression was effectively prevented by adoptive transfer of a small number of islet Ag-specific CD4+CD25+ Tregs to CY-treated recipients. Prevention of T1D was associated with reduced T cell activation and higher Treg proportions in the pancreas. We conclude that acceleration of T1D by CY is associated with a reduction in CD4+CD25+Foxp3+ Tregs and can be prevented by transfer of CD4+CD25+ Tregs.
Engineering integrin‐specific surfaces with a triple‐helical collagen‐mimetic peptide (2003)

Integrin-mediated cell adhesion to extracellular matrix proteins anchors cells and triggers signals that direct cell function. The integrin alpha(2)beta(1) recognizes the glycine-phenylalanine-hydroxyproline-glycine-glutamate-arginine (GFOGER) motif in residues 502-507 of the alpha(1)(I) chain of type I collagen. Integrin recognition is entirely dependent on the triple-helical conformation of the ligand similar to that of native collagen. This study focuses on engineering alpha(2)beta(1)-specific bioadhesive surfaces by immobilizing a triple-helical collagen-mimetic peptide incorporating the GFOGER binding sequence onto model nonadhesive substrates. Circular dichroism spectroscopy verified that this peptide adopts a stable triple-helical conformation in solution. Passively adsorbed GFOGER-peptide exhibited dose-dependent HT1080 cell adhesion and spreading comparable to that observed on type I collagen. Subsequent antibody blocking conditions verified the involvement of integrin alpha(2)beta(1) in these adhesion events. Focal adhesion formation was observed by immunofluorescent staining for alpha(2)beta(1) and vinculin on MC3T3-E1 cells. Model functionalized surfaces then were engineered using three complementary peptide-tethering schemes. These peptide-functionalized substrates supported alpha(2)beta(1)-mediated cell adhesion and focal adhesion assembly. Our results suggest that this peptide is active in an immobilized conformation and may be applied as a surface modification agent to promote alpha(2)beta(1)-specific cell adhesion. Engineering surfaces that specifically target certain integrin-ligand interactions and signaling cascades provides a biomolecular strategy for optimizing cellular responses in biomaterials and tissue engineering applications.
NADA: A Unified Congestion Control Scheme for Low-Latency Interactive Video (2013)

Low-latency, interactive media applications (e.g., video conferencing) present a unique set of challenges for congestion control. Unlike TCP, the transport mechanism for interactive media needs to adapt fast to abrupt changes in available bandwidth, accommodate sluggish responses and output rate fluctuations of a live video encoder, and avoid high queuing delay over the network. An ideal scheme should also make effective use of all types of congestion signals from the network, including packet losses, queuing delay, and explicit congestion notification (ECN) markings. This paper presents a unified approach for congestion control of interactive video: network-assisted dynamic adaptation (NADA). In NADA, the sender regulates its sending rate based on a composite congestion signal calculated and reported by the receiver, which combines both implicit (e.g., loss and delay) and explicit (e.g., ECN marking) congestion indications from the network. Via a consistent set of sender adaptation rules, the scheme can reap the full benefits of proactive, explicit congestion notifications supported by advanced queue management schemes. It remains equally responsive in the absence of such notifications. Extensive simulation studies show that NADA interact well with a wide variety of queue management schemes: conventional drop-tail, random early detection (RED), recently proposed CoDel (controlled delay) and PIE (Proportional Integral controller Enhanced), as well as a token-bucket-based random marking scheme based on Pre-Congestion Notification (PCN). Furthermore, NADA reacts fast to changes over the network, allows for weighted bandwidth sharing among multiple competing video streams, and sustains a substantial share of bottleneck bandwidth when coexisting with TCP.
Muscle Biopsy (2001)

<b>INTRODUCTION</b> Good clinical evaluation remains the most effective tool in the assessment of disorders of muscle. Muscle biopsy, like expensive genetic analysis, when used appropriately is a valuable diagnostic aid. When undertaken inappropriately, at best it wastes the time and resources of the surgeon and histopathology department, and at worst has subjected the patient to an unnecessary invasive test. The usefulness of a muscle biopsy depends on consideration of all the following four criteria: appropriateness of the test; choice of muscle; biopsy technique; array of histopathology performed. <b>APPROPRIATENESS OF THE TEST</b> <b>Biopsy is most useful for the diagnosis of:</b> Inflammatory myopathies (diagnosis and to monitor treatment). Certain muscular dystrophies for which the structural abnormality is known but genetic testing is not readily available (where there are many different mutations within the abnormal gene, e.g. the sarcoglycanopathies). Mitochondrial cytopathies, both to look for the
Non-Invasive Wearable Patch Utilizing Seismocardiography for Peri-Operative Use in Surgical Patients (2020)

This work shows promise for the proposed wearable-based methodology to be used as an alternative to TED for continuous patient monitoring and guiding peri-operative fluid management.
Cooperation Through Threats: The Northern Ireland Case (1998)

On February 9, 1996, after a seventeen-month cease-fire, the Irish Republican Army (IRA) set off a bomb in East London. Less than a week later, the London police found and destroyed a bomb that the IRA had left in a telephone booth in the West End. A few days later, another IRA bomb went off on a doubledecker bus. The British government, under the leadership of John Major, asserted that it would have no official contact with Sinn Féin, the political arm of the IRA, until the paramilitary activities stopped. The government also deployed 500 additional troops in Northern Ireland. In October 1996, the IRA detonated two bombs at the British Army's headquarters in Lisburn, bringing the violent conflict back to Northern Ireland for the first time since the cease-fire. On May 1, 1997, Tony Blair was elected Great Britain's prime minister. His election brought a renewed sense of optimism and good will to the conflict in Northern Ireland. Responding to Blair's overtures, including his warning that “the settlement train is leaving, with or without them” (Hoge 1997a, A7), the IRA announced on July 19, 1997, that they had “ordered the unequivocal restoration of the cease-fire” (Clarity 1997c, 1). Soon thereafter, Sinn Féin was invited to participate in the peace talks, which reconvened on September 15, 1997.
Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv) (2010)

Diabodies (Dbs) and tandem single-chain variable fragments (taFv) are the most widely used recombinant formats for constructing small bispecific antibodies. However, only a few studies have compared these formats, and none have discussed their binding kinetics and cross-linking ability. We previously reported the usefulness for cancer immunotherapy of a humanized bispecific Db (hEx3-Db) and its single-chain format (hEx3-scDb) that target epidermal growth factor receptor and CD3. Here, we converted hEx3-Db into a taFv format to investigate how format affects the function of a small bispecific antibody; our investigation included a cytotoxicity assay, surface plasmon resonance spectroscopy, thermodynamic analysis, and flow cytometry. The prepared taFv (hEx3-taFv) showed an enhanced cytotoxicity, which may be attributable to a structural superiority to the diabody format in cross-linking target cells but not to differences in the binding affinities of the formats. Comparable cross-linking ability for soluble antigens was observed among hEx3-Db, hEx3-scDb, and hEx3-taFv with surface plasmon resonance spectroscopy. Furthermore, drastic increases in cytotoxicity were found in the dimeric form of hEx3-taFv, especially when the two hEx3-taFv were covalently linked. Our results show that converting the format of small bispecific antibodies can improve their function. In particular, for small bispecific antibodies that target tumor and immune cells, a functional orientation that avoids steric hindrance in cross-linking two target cells may be important in enhancing the growth inhibition effect.
Treatment of Down's Syndrome With the "U" Series of Drugs (1964)

IN REPORTING RESULTS of his medical research and treatment of mongolism,<sup>1</sup>Turkel of Detroit summarized his results as follows: It was intended to bring the Mongoloid to a physical condition as nearly normal as possible using medication to favorably alter the inborn structural anomalies, something heretofore considered impossible. X-rays and photographs have demonstrated that it is possible when the "U" series of drugs are used. This first breakthrough in the medical treatment of mongoloids should now stimulate physicians to improve the treatment. In reporting the results of treatment of 60 patients with the "U" series of drugs to the Section of Medical Science at the Annual Meeting of the New Jersey Academy of Science on April 7, 1962, Turkel stated: Mongoloids and other types of physically and mentally retarded individuals can be brought to near-normalcy by the "U" series of drugs in a treatment which the physician can manage from his office while the patient remains at home.