gebhart/patrepeval huggingface dataset:
High resolution aquifer characterization using crosshole GPR full‐waveform tomography: Comparison with direct‐push and tracer test data (2016)

Abstract Limited knowledge about the spatial distribution of aquifer properties typically constrains our ability to predict subsurface flow and transport. Here we investigate the value of using high resolution full‐waveform inversion of cross‐borehole ground penetrating radar (GPR) data for aquifer characterization. By stitching together GPR tomograms from multiple adjacent crosshole planes, we are able to image, with a decimeter scale resolution, the dielectric permittivity and electrical conductivity of an alluvial aquifer along cross sections of 50 m length and 10 m depth. A logistic regression model is employed to predict the spatial distribution of lithological facies on the basis of the GPR results. Vertical profiles of porosity and hydraulic conductivity from direct‐push, flowmeter and grain size data suggest that the GPR predicted facies classification is meaningful with regard to porosity and hydraulic conductivity, even though the distributions of individual facies show some overlap and the absolute hydraulic conductivities from the different methods (direct‐push, flowmeter, grain size) differ up to approximately one order of magnitude. Comparison of the GPR predicted facies architecture with tracer test data suggests that the plume splitting observed in a tracer experiment was caused by a hydraulically low‐conductive sand layer with a thickness of only a few decimeters. Because this sand layer is identified by GPR full‐waveform inversion but not by conventional GPR ray‐based inversion we conclude that the improvement in spatial resolution due to full‐waveform inversion is crucial to detect small‐scale aquifer structures that are highly relevant for solute transport.
Configurational Effects on the Proton Magnetic Resonance Spectra of Six-membered Ring Compounds1 (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConfigurational Effects on the Proton Magnetic Resonance Spectra of Six-membered Ring Compounds1R. U. Lemieux, R. K. Kullnig, H. J. Bernstein, and W. G. SchneiderCite this: J. Am. Chem. Soc. 1958, 80, 22, 6098–6105Publication Date (Print):November 1, 1958Publication History Published online1 May 2002Published inissue 1 November 1958https://pubs.acs.org/doi/10.1021/ja01555a051https://doi.org/10.1021/ja01555a051research-articleACS PublicationsRequest reuse permissionsArticle Views899Altmetric-Citations424LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Infant Feeding on the Risk of Obesity Across the Life Course: A Quantitative Review of Published Evidence (2005)

Initial breastfeeding protects against obesity in later life. However, a further review including large unpublished studies exploring the effect of confounding factors in more detail is needed.
Polysaccharide Produced by the Genus Pullularia (1963)

A dextranlike polysaccharide was found to be produced on substrates of sucrose, maltose, glucose, and fructose by growing cells of various strains of the genus Pullularia. The polysaccharide, obtainable in amounts as large as 2 to 3 g per 100 ml of culture medium using various carbohydrates as the carbon source, was soluble in cold water but not in 50% alcohol. The polysaccharide obtained had a alpha(d) = +197.5 degrees (c = 0.2 in water), and its molecular weight, determined by the light-scattering method, was found to be approximately 250,000.
Complex-valued neural networks with adaptive spline activation function for digital-radio-links nonlinear equalization (1999)

In this paper, a new complex-valued neural network based on adaptive activation functions is proposed. By varying the control points of a pair of Catmull-Rom cubic splines, which are used as an adaptable activation function, this new kind of neural network can be implemented as a very simple structure that is able to improve the generalization capabilities using few training samples. Due to its low architectural complexity (low overhead with respect to a simple FIR filter), this network can be used to cope with several nonlinear DSP problems at a high symbol rate. In particular, this work addresses the problem of nonlinear channel equalization. In fact, although several authors have already recognized the usefulness of a neural network as a channel equalizer, one problem has not yet been addressed: the high complexity and the very long data sequence needed to train the network. Several experimental results using a realistic channel model are reported that prove the effectiveness of the proposed network on equalizing a digital satellite radio link in the presence of noise, nonlinearities, and intersymbol interference (ISI).
Platelet serotonin uptake in men with family histories of alcoholism. (1991)

Platelet serotonin uptake kinetics were examined in a carefully screened group of 28 male subjects, half of whom had an alcoholic father. Paired subjects were matched for a variety of characteristics, including age, race, sex, substance use history, height/weight ratio, season, and time of day for platelet serotonin uptake assays. The family history positive group had a significantly (p = 0.01) higher mean Vmax for platelet serotonin uptake (64.1 +/- 19, SD) compared to the control group without family histories of first-degree relatives with alcoholism (53.8 +/- 19). No significant differences in the affinity constant (Km) or in the Hill constant were found between groups. The results are consistent with the possibility that a higher Vmax of platelet serotonin uptake indicates a biologic factor associated with alcoholism risk.
Notes - Thermal Reactions of Pefluorobutyne-2 and Perfluoropropene (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Thermal Reactions of Pefluorobutyne-2 and PerfluoropropeneHenry BrownCite this: J. Org. Chem. 1957, 22, 10, 1256–1257Publication Date (Print):October 1, 1957Publication History Published online23 April 2003Published inissue 1 October 1957https://pubs.acs.org/doi/10.1021/jo01361a604https://doi.org/10.1021/jo01361a604research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver (1971)

The first in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor
 in separating glucagon, a hormone that can act to increase blood glucose levels, from the cell's receptor, which had important
 implications for the treatment of various disorders and diseases.
<i>L</i>-Tyrosine as an Immunological Adjuvant (1982)

A series of experiments has been carried out to investigate the adjuvant properties of the amino acid L-tyrosine in laboratory animals. Adsorption of various allergenic materials to L-tyrosine was found to enhance the induction of IgG antibodies, but no unusual propensity to stimulate IgE antibody or delayed hypersensitivity was observed. Administration of the amino acid at a site remote from the allergen was found not to augment antibody production. This, together with evidence of reduced bioavailability of the tyrosine-adsorbed allergen, suggested that the adjuvant activity observed resulted from a short-term depot effect.
A Feasibility Study of Parametric Response Map Analysis of Diffusion-Weighted Magnetic Resonance Imaging Scans of Head and Neck Cancer Patients for Providing Early Detection of Therapeutic Efficacy (2009)

The parametric response map (PRM) was evaluated as an early surrogate biomarker for monitoring treatment-induced tissue alterations in patients with head and neck squamous cell carcinoma (HNSCC). Diffusion-weighted magnetic resonance imaging (DW-MRI) was performed on 15 patients with HNSCC at baseline and 3 weeks after treatment initiation of a nonsurgical organ preservation therapy (NSOPT) using concurrent radiation and chemotherapy. PRM was applied on serial apparent diffusion coefficient (ADC) maps that were spatially aligned using a deformable image registration algorithm to measure the tumor volume exhibiting significant changes in ADC (PRM(ADC)). Pretherapy and midtherapy ADC maps, quantified from the DWIs, were analyzed by monitoring the percent change in whole-tumor mean ADC and the PRM metric. The prognostic values of percentage change in tumor volume and mean ADC and PRM(ADC) as a treatment response biomarker were assessed by correlating with tumor control at 6 months. Pixel-wise differences as part of PRM(ADC) analysis revealed regions where water mobility increased. Analysis of the tumor ADC histograms also showed increases in mean ADC as early as 3 weeks into therapy in patients with a favorable outcome. Nevertheless, the percentage change in mean ADC was found to not correlate with tumor control at 6 months. In contrast, significant differences in PRM(ADC) and percentage change in tumor volume were observed between patients with pathologically different outcomes. Observations from this study have found that diffusion MRI, when assessed by PRM(ADC), has the potential to provide both prognostic and spatial information during NSOPT of head and neck cancer.
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: Results of the two‐year multinational knee osteoarthritis structural arthritis study (2006)

Although risedronate (compared with placebo) did not improve signs or symptoms of OA, nor did it alter progression of OA, a reduction in the level of a marker of cartilage degradation was observed. A sustained clinically relevant improvement in signs and symptoms was observed in all treatment and placebo groups.
Inorganic polyphosphate and specific induction of apoptosis in human plasma cells. (2006)

Taken together, our results suggest for the first time the relevance of the use of polyP to the humoral immune response and open prospects for polyP as a novel therapy for myeloma.
Clq acts synergistically with phorbol dibutyrate to activate CR1‐mediated phagocytosis by human mononuclear phagocytes (1988)

The adherence of human monocytes and culture-derived macrophages to surfaces coated with complement subcomponent C1q has been previously shown to enhance Fc receptor (FcR)-mediated phagocytosis by these cells. We examined the effects of C1q on C3b/C4b receptor (CR1)-mediated phagocytosis by mononuclear phagocytes. A small percentage of human monocytes cultured in the presence of serum became competent to ingest sheep erythrocytes bearing IgM and C4b (EAC4b). This phagocytic activity was enhanced when these cultured-derived macrophages were adhered to C1q-coated surfaces. However, when cultured in a defined serum-free medium, these cells did not ingest EAC4b, even in the presence of C1q. To investigate this differential responsiveness, we studied the effects of C1q in conjunction with cell-activating agents on CR1 activation. Treatment of serum-free cultured monocytes with phorbol dibutyrate (PDBu), prior to addition of the targets, induced these cells to ingest EAC4b. In addition, when exposed to C1q, both the percentage of these PDBu mononuclear phagocytes ingesting EAC4b and the number of targets ingested increased threefold over the level achieved by macrophages treated with PDBu alone. The chemoattractant N-formyl-methionyl-leucyl-phenylalanine did not activate CR1-mediated phagocytosis and did not substitute for PDBu in causing synergy with C1q. Freshly isolated monocytes adhered to human serum albumin-coated glass slides in the absence or presence of PDBu did not phagocytose EAC4b. Also C1q did not stimulate monocyte CR1-mediated phagocytosis. However, addition of PDBu to cells adherent to the C1q surface triggered phagocytosis of EAC4b. The concentration of PDBu and the time of addition of PDBu relative to addition of the EAC4b targets were found to be important parameters for the achievement of maximal synergy in both the freshly isolated and cultured cell systems. This enhanced phagocytic activity was also seen with cells adhered to the purified collagen-like, pepsin-resistant, fragment of C1q. Since this region was previously shown to interact with C1q surface receptors, it appears that occupancy of this receptor is triggering events contributing to the enhanced cellular function. These experiments suggest that C1q and PDBu promote ingestion via CR1 by different but synergistic mechanisms. These data also demonstrate that the CR1-mediated enhancement of phagocytosis is not specific for FcR-mediated ingestion, but also applies to phagocytosis via CR1.
Isolation of Latent Herpes Simplex Virus from the Superior Cervical and Vagus Ganglions of Human Beings (1978)

HERPES simplex virus has been found to be present in a latent form in the trigeminal and spinal ganglions of animals1 , 2 and human beings.3 , 4 In our previous study,5 we recovered herpes simplex virus Type I from trigeminal ganglions of 12 out of 20 cadavers, 18 being patients who had died of trauma. The purpose of this study was to determine whether this virus could be isolated from other human ganglions. Since latent herpes simplex virus has been detected in the superior cervical ganglions of mice,6 this ganglion was selected for virus-isolation studies. In addition, the jugular portion of the vagus . . .
Explaining Watson: Polymath Style (2015)

Our paper is actually two contributions in one. First, we argue that IBM's Jeopardy! playing machine needs a formal semantics. We present several arguments as we discuss the system. We also situate the work in the broader context of contemporary AI. Our second point is that the work in this area might well be done as a broad collaborative project. Hence our "Blue Sky'' contribution is a proposal to organize a polymath-style effort aimed at developing formal tools for the study of state of the art question-answer systems, and other large scale NLP efforts whose architectures and algorithms lack a theoretical foundation.
A Within‐Group Design of Nontreatment Seeking 5‐HTTLPR Genotyped Alcohol‐Dependent Subjects Receiving Ondansetron and Sertraline (2008)

This study suggests that ondansetron may reduce alcohol consumption in alcohol-dependent individuals who have the L/L genotype as measured naturalistically and during the ASAE. By contrast there was no support that sertraline reduces alcohol use in individuals who have S/S or S/L genotypes. Evidence in the literature suggests that AD in some individuals may be influenced by a gene by socio-environmental interaction making pharmacological treatment with serotonergic drugs complex. Research must consider that typologies may predict successful treatment of AD in future trials.
Evaluation of Different Image Interpolation Algorithms (2012)

Interpolation is the process of transferring image from one resolution to another without losing image quality. In Image processing field, image interpolation is very important function for doing zooming, enhancement of image, resizing any many more. Here in this paper, we have reviewed different interpolation algorithms. We have implemented all reviewed interpolation algorithms and done comparison of all.
Hepatitis B Virus Polymerase Blocks Pattern Recognition Receptor Signaling via Interaction with DDX3: Implications for Immune Evasion (2010)

Viral infection leads to induction of pattern-recognition receptor signaling, which leads to interferon regulatory factor (IRF) activation and ultimately interferon (IFN) production. To establish infection, many viruses have strategies to evade the innate immunity. For the hepatitis B virus (HBV), which causes chronic infection in the liver, the evasion strategy remains uncertain. We now show that HBV polymerase (Pol) blocks IRF signaling, indicating that HBV Pol is the viral molecule that effectively counteracts host innate immune response. In particular, HBV Pol inhibits TANK-binding kinase 1 (TBK1)/IkappaB kinase-epsilon (IKKepsilon), the effector kinases of IRF signaling. Intriguingly, HBV Pol inhibits TBK1/IKKepsilon activity by disrupting the interaction between IKKepsilon and DDX3 DEAD box RNA helicase, which was recently shown to augment TBK1/IKKepsilon activity. This unexpected role of HBV Pol may explain how HBV evades innate immune response in the early phase of the infection. A therapeutic implication of this work is that a strategy to interfere with the HBV Pol-DDX3 interaction might lead to the resolution of life-long persistent infection.
UTLB (1998)

An important aspect of a high-speed network system is the ability to transfer data directly between the network interface and application buffers. Such a direct data path requires the network interface to "know" the virtual-to-physical address translation of a user buffer, i.e ., the physical memory location of the buffer. This paper presents an efficient address translation architecture, User-managed TLB (UTLB), which eliminates system calls and device interrupts from the common communication path. UTLB also supports application-specific policies to pin and unpin application memory. We report micro-benchmark results for an implementation on Myrinet PC clusters. A trace-driven analysis is used to compare the UTLB approach with the interrupt-based approach. It is also used to study the effects of UTLB cache size, associativity, and prefetching. Our results show that the UTLB approach delivers robust performance with relatively small translation cache sizes.
Comparison of the Expression of a Mutant Dihydrofolate Reductase under Control of Different Internal Promoters in Retroviral Vectors (1992)

To determine the effect of different promoters on the expression of an altered dihydrofolate reductase (DHFR) gene conferring methotrexate (MTX) resistance in different cell types, double-copy retroviral vectors were constructed carrying a murine mutant DHFR under the control of five different promoters, i.e., human adenosine deaminase (ADA), simian virus 40 (SV40), thymidine kinase (TK), human beta-actin, and cytomegalovirus (CMV). Their expression was compared in NIH-3T3 cells, three human leukemia cell lines, and mouse bone marrow. The variant DHFR is readily expressed from these various promoters in retroviral vectors at a selectable level. In 3T3 cells, the DHFR constructs containing the SV40 promoter conferred the highest levels of resistance to MTX. In K562 and Raji cells, the construct with the TK promoter produced the highest level of resistance. However granulocyte-macrophage colony-forming unit (CFU-GM) colonies from mouse marrow were more resistant to MTX when infected with vectors containing the SV40 promoter and ADA promoter as compared to the other promoter constructs. These studies show that mouse fibroblast cell lines such as NIH-3T3 do not predict the effectiveness of retroviral-mediated gene transfer for marrow progenitor cells, and that the activity of retroviral vector-encoded promoters vary in an unpredictable manner from cell type to cell type. Possible implications for basic gene transfer studies and clinical applications are discussed.
Phase I chemoprevention study of difluoromethylornithine in subjects with organ transplants. (2001)

Individuals who receive life-saving organ transplants and the required immunosuppression often develop secondary cancers. One of the most common secondary cancers is nonmelanoma skin cancer in sun-exposed areas. Attempts to prevent these cancers have not been successful. Difluoromethylornithine (DFMO), a suicide inhibitor of ornithine decarboxylase (ODC), is a known experimental cancer prevention agent that is being evaluated in a number of human cancer prevention trials. This report describes a Phase I trial in 18 organ transplant recipients, randomized to 1.0 and 0.5 g of DFMO or a placebo, designed to look at short-term toxicities over 28 days as well as the impact of DFMO on two biological parameters, skin polyamines and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity. Blood levels of DFMO were also measured. The results indicate that DFMO was well tolerated over the 28-day period. The TPA-induced ODC activity in 3-mm skin biopsies was significantly lowered by 80 and 67% at the two dose levels. Polyamine levels were not affected significantly except for putrescine at the 0.5-g level. Blood levels of DFMO were about two times higher than expected, based on our prior pharmacokinetic studies. Our studies indicate that DFMO is a reasonable agent that should be tested further in larger Phase 2b trials in this population as a chemopreventive agent. TPA-induced ODC activity appears to be a relevant intermediate biological assay.