gebhart/patrepeval huggingface dataset:
Correlation between Low Levels of Maternal IgG Antibodies to R Protein and Neonatal Septicemia with Group B Streptococci Carrying R Protein (1983)

A method was designed for quantitation of serum antibodies to R protein in group B streptococci (GBS). Four sera from mothers of infants with neonatal septicemia caused by type II, R+ GBS showed a binding range from 400 to 740 cpm in contrast to a range of 690-1,220 cpm in 5 parturients carrying type II, R+ strains in the urogenital tract giving birth to healthy infants (p less than 0.05). The range of antibodies in sera from 8 mothers to infants infected with GBS type III,R+ was 370-750 cpm, whereas the range in sera from 10 carriers of type III,R+ giving birth to healthy infants varied between 510 and 1,280 cpm (p less than 0.01). These findings indicate that R protein is an important virulence factor in neonatal GBS septicemia/meningitis.
Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors:  Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, and N-Hydroxysulfonamides Inhibit Both These Zinc Enzymes (2001)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCarbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, and N-Hydroxysulfonamides Inhibit Both These Zinc EnzymesAndrea Scozzafava and Claudiu T. SupuranCite this: J. Med. Chem. 2001, 44, 6, 1016Publication Date (Web):March 8, 2001Publication History Published online8 March 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/jm0004852https://doi.org/10.1021/jm0004852correctionACS PublicationsCopyright © 2001 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views601Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (14 KB) Get e-Alertsclose Get e-Alerts
Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part I. Measurement of Very Small Optical Rotations (1982)

We have described the concept of using the aqueous humor glucose as a measure of the blood glucose concentration, with a view to developing a noninvasive glucose monitor for diabetic individuals. We have conceived of a scleral lens that houses a light source, polarizers, other electro-optic units, and a light detector, and which measures the optical rotation of the aqueous humor continuously. We have built an optical bench mock-up of the glucose sensor and assessed the limits of its capabilities. We have described a physical method, employing the Faraday effect, that modulates the incident light and uses a compensator to introduce a feedback mechanism giving a null-point technique capable of measuring extremely small rotations with an accuracy of 0.4 s of arc. We have used this and have measured the optical rotations of glucose solutions from 0.02 to 0.1%, and have demonstrated linearity in both cases. Miniaturization of the technique is discussed.
Matrix Attachment Regulates FAS-Induced Apoptosis in Endothelial Cells (2001)

Survival of endothelial cells is critical for cellular processes such as angiogenesis. Cell attachment to extracellular matrix inhibits apoptosis in endothelial cells both in vitro and in vivo, but the molecular mechanisms underlying matrix-induced survival signals or detachment-induced apoptotic signals are unknown. We demonstrate here that matrix attachment is an efficient regulator of Fas-mediated apoptosis in endothelial cells. Thus, matrix attachment protects cells from Fas-induced apoptosis, whereas matrix detachment results in susceptibility to Fas-mediated cell death. Matrix attachment modulates Fas-mediated apoptosis at two different levels: by regulating the expression level of Fas, and by regulating the expression level of c-Flip, an endogenous antagonist of caspase-8. The extracellular signal-regulated kinase (Erk) cascade functions as a survival pathway in adherent cells by regulating c-Flip expression. We further show that detachment-induced cell death, or anoikis, itself results from activation of the Fas pathway by its ligand, Fas-L. Fas-L/Fas interaction, Fas-FADD complex formation, and caspase-8 activation precede the bulk of anoikis in endothelial cells, and inhibition of any of these events blocks anoikis. These studies identify matrix attachment as a survival factor against death receptor-mediated apoptosis and provide a molecular mechanism for anoikis and previously observed Fas resistance in endothelial cells.
Activated Monocytes Prime Naïve T Cells Against Autologous Cancer: Vigorous Cancer DestructionIn VitroandIn Vivo (2011)

It has not been considered so far that antigen-presenting cells (APC) may phagocytose immunogenic material from autologous cancer cells. Assuming the presence of cancer-immunogenic material in APC, we developed a novel autologous priming method that does not require tumour cells or identified peptides. Cancer-immunogenic information came from CD14+ monocytes. When stimulated with CD3-activated T cells, monocytes primed CD3+ CD4+ and CD3+ CD8+ resting/naïve T cells to become powerful effector cells within 24 h. During priming, depletion of CD14+ monocytes but not CD1a+ CD83+ dendritic cells prevented T cell priming. During cancer cell destruction, dendritic cells, but not monocytes, enhanced cancer cell lysis. The cascade-primed (CAPRI) immune cell quartet comprising monocytes, dendritic cells, CD4+ T and CD8+ T cells induced a significant decrease in the number of suppressive CD25(high) FoxP3+ CD4+ T cells. CAPRI cells induced a marked upregulation of MHC class I and class II expression in cancer cells, which is crucial for autoimmune-like lysis. We show in vivo evidence of the CAPRI cell concept in nude mice. In humans, we present circumstantial clinical evidence showing the efficacy of CAPRI cells in an adjuvant treatment attempt for breast cancer patients with metastasis (N = 42). Compared to patients at the Munich Tumor Center (no CAPRI treatment N = 428), almost double the expected number of patients survived 5 years (P =1.36 × 10⁻¹⁴). The CAPRI method is a safe procedure without negative side effects. High numbers of cancer-specific CAPRI cells can be obtained within a week against different cancer types for efficient adoptive cell therapy.
The Dual Role of IL-2 in the Generation and Maintenance of CD8+ Memory T Cells (2000)

The mechanisms responsible for the generation and maintenance of T cell memory are unclear. In this study, we tested the role of IL-2 in allospecific CD8+ T cell memory by analyzing the long-term survival, phenotype, and functional characteristics of IL-2-replete (IL-2+/+) and IL-2-deficient (IL-2-/-) CD8+ TCR-transgenic lymphocytes in an adoptive transfer model. We found that IL-2 is not essential for the in vivo generation, maintenance, or recall response of CD8+ memory T cells. However, IL-2 increased the size of the CD8+ memory pool if present at the time of initial T cell activation but reduced the size of the pool if present during memory maintenance by inhibiting the proliferation of CD8+ memory T cells. Thus, IL-2-based vaccine strategies or immunosuppressive regimens that target IL-2 should take into account the divergent roles of IL-2 in CD8+ T cell immunity.
Reduced-Complexity Decoder Architecture for Non-Binary LDPC Codes (2010)

Non-binary low-density parity-check (NB-LDPC) codes can achieve better error-correcting performance than binary LDPC codes when the code length is moderate at the cost of higher decoding complexity. The high complexity is mainly caused by the complicated computations in the check node processing and the large memory requirement. In this paper, a novel check node processing scheme and corresponding VLSI architectures are proposed for the Min-max NB-LDPC decoding algorithm. The proposed scheme first sorts out a limited number of the most reliable variable-to-check (v-to-c) messages, then the check-to-variable (c-to-v) messages to all connected variable nodes are derived independently from the sorted messages without noticeable performance loss. Compared to the previous iterative forward-backward check node processing, the proposed scheme not only significantly reduced the computation complexity, but eliminated the memory required for storing the intermediate messages generated from the forward and backward processes. Inspired by this novel c-to-v message computation method, we propose to store the most reliable v-to-c messages as “compressed” c-to-v messages. The c-to-v messages will be recovered from the compressed format when needed. Accordingly, the memory requirement of the overall decoder can be substantially reduced. Compared to the previous Min-max decoder architecture, the proposed design for a (837, 726) code over <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF</i> (2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> ) can achieve the same throughput with only 46% of the area.
CRIGOS – Development of a compact robot system for image-guided orthopedic surgery (2000)

In this paper, we present a medical robot system dedicated to support the surgeon during challenging tasks within orthopedic interventions. The main goal of this work is to develop a system as technically simple as the surgical requirements allow to keep its cost and complexity to a minimum. Therefore, we primarily focus on calibrated X-ray imaging for image acquisition, an easy registration procedure and robotic execution using a positioning device with simple parallel kinematics. Examples of different orthopedic interventions using the compact robot system for image-guided orthopedic surgery (CRIGOS) are presented, as well as various modes of execution of the device.
D/H ratios and H2O contents of mantle-derived amphibole megacrysts from Dish Hill, California (1994)

D/H ratios are, in principle, useful in characterizing reservoirs of mantle hydrogen and as tracers of volatile transfer processes in Earth's interior. In practice, however, interpretation of isotopic measurements on mantle derived H is complicated by surface processes such as contamination and degassing which may alter the primary D/H ratio. Although there are indications that water associated with subduction zones and certain chemically enriched basalts is enriched in D relative to 'typical' upper mantle water, the extent of isotopic heterogeneity of mantle H remains uncertain. Kaersutitic amphibole megacrysts in alkaline basalts are one of the most widespread sources of mantle water and are therefore potentially useful for large-scale regional studies of D/H variation. However, D/H ratios of these amphiboles vary widely (from plus 8 to minus 113 percent), even in samples from the same locality, so that this potential has yet to be realized. In order to investigate the origin of this variability, and to explore the possibility that primary mantle D/H ratios may be deduced from these amphiboles, we analyzed the D/H ratios and chemical compositions of a suite of 17 kaersutitic amphiboles from Dish Hill, California. This work contrasts with previous studies in which sampling is widespread, but representatives from any given locality are few. Samples were collected from a restricted area on the southern flank of the volcanic center and are associated with the basal volcanic breccia. Fourteen of the samples were large single crystals or crystal fragments (megacrysts, 0.4 to 30 grams), believed to derive from pegmatitic veins crystallized from melts in the mantle. Two were coarse-grained intergrowths of amphibole with olivine and spinel, and one was a thin (2 mm) selvage on a peridotite xenolith.
Chromosomal instability (2003)

The pace of discoveries into the biologic basis of chromosomal instability in cancer cells is quickening and the various causes, previously thought to be unrelated, are being found to be intertwined. Because chromosomal instability is likely to be a main mechanism behind tumor evasion of therapy, understanding the causes and their implications for diagnostic and prognostic evaluation and therapy is of tantamount importance.
Complement Receptors (2001)

Abstract Complement receptors are membrane proteins expressed on the surface of immune cells. They interact specifically with complement factors leading to the removal of antigen from the circulation.
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis (2011)

Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves both fluid secretion and abnormal proliferation of cyst-lining epithelial cells. The chloride channel of the cystic fibrosis transmembrane conductance regulator (CFTR) participates in secretion of cyst fluid, and the mammalian target of rapamycin (mTOR) pathway may drive proliferation of cyst epithelial cells. CFTR and mTOR are both negatively regulated by AMP-activated protein kinase (AMPK). Metformin, a drug in wide clinical use, is a pharmacological activator of AMPK. We find that metformin stimulates AMPK, resulting in inhibition of both CFTR and the mTOR pathways. Metformin induces significant arrest of cystic growth in both in vitro and ex vivo models of renal cystogenesis. In addition, metformin administration produces a significant decrease in the cystic index in two mouse models of ADPKD. Our results suggest a possible role for AMPK activation in slowing renal cystogenesis as well as the potential for therapeutic application of metformin in the context of ADPKD.
Reducing the X-ray radiation exposure frequency in cardio-angiography via deep-learning based video interpolation (2020)

Cardiac coronary angiography is a major technology to assist doctors during cardiac interventional surgeries. Under the exposure of X-ray radiation, doctors inject contrast agents through catheters to determine the position and status of coronary vessels in real time. To get a coronary angiography video with a high frame rate, the doctor needs to increase the exposure frequency and intensity of the X-ray. This will inevitably increase the X-ray harm to both patients and surgeons. In this work, we innovatively utilize a deep-learning based video interpolation algorithm to interpolate coronary angiography videos. Moreover, we establish a new coronary angiography image dataset ,which contains 95,039 triplets images to retrain the video interpolation network model. Using the retrained network we synthesize high frame rate coronary angiography video from the low frame rate coronary angiography video. The average peak signal to noise ratio(PSNR) of those synthesized video frames reaches 34dB. Extensive experiment results demonstrate the feasibility of using the video frame interpolation algorithm to synthesize continuous and clear high frame rate coronary angiography video. With the help of this technology, doctors can significantly reduce exposure frequency and intensity of the X-ray during coronary angiography.
A DESIGN METHODOLOGY FOR SELF-TIME SYSTEMS (1981)

This thesis presents a design methodology for self-timed systems which will be extremely attractive for implementing systems in VLSI. Self-timed systems are characterized by the absence of a timing reference to which all operations are synchronized.
Multicast transport protocols for high speed networks (2002)

This paper presents the design and analysis of three reliable multicast transport protocols for high speed networks. The novelty of these protocols lies in the technique used in combining the acknowledgments of individual destinations along the underlying multicast tree to prevent acknowledgement implosion and in the technique used in preventing unnecessary retransmission by performing local multicasts. These protocols use the periodic exchange of complete state information between the source and the destinations and a block-based Selective Repeat retransmission scheme to improve the overall performance in a high speed networking environment. Performance of each protocol is analyzed in terms of throughput, end-to-end delay, buffer requirement, acknowledgment traffic and retransmission traffic. Based on this analysis and the complexity of implementation, one of the three protocols is recommended for reliable multicasting in high speed networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evaluation of an Enzyme‐Linked Immunosorbent Assay Based on Binding Inhibition for Type‐Specific Quantification of Poliovirus Neutralization‐Relevant Antibodies (1999)

To detect neutralization-relevant antibodies against 3 types of poliovirus (PV) without using tissue cultures and live viruses, an enzyme-linked immunosorbent assay (ELISA) based on monoclonal antibody-binding inhibition was evaluated using sera from 80 vaccinated Japanese children and 60 Pakistani poliomyelitis patients. Compared with the neutralization test, the sensitivity of the inhibition ELISA was 100% (111/111) for detection of anti-PV1 antibody, 98.3% (118/120) for anti-PV2, and 96.5% (82/85) for anti-PV3, and the specificity was 93.1% (27/29), 100% (20/20), and 92.7% (51/55), respectively. Thus, the inhibition ELISA showed excellent potential as a seroepidemiologic tool in both vaccinated and naturally-infected populations.
Cytokine Gene Therapy for Cancer with Naked DNA (2000)

Plasmid DNA vectors (naked DNA) can easily be purified and transferred in vivo by intramuscular or intradermal injection. Naked DNA is stable in vivo, and long-term expression of the encoded protein is seen without chromosomal integration. Gene gun-mediated delivery of an expression plasmid is slightly more complicated but more efficient. These techniques have been applied to DNA vaccination or cytokine gene therapy for various diseases, including infections, autoimmune disorders, and cancer. We review cytokine gene therapy for cancer with naked DNA in animal models and present our preliminary data on gene gun-mediated in vivo transfection with the interleukin-12 gene in a murine renal cancer model. Because of its safety, simplicity, and low cost, cytokine gene therapy with naked DNA may become an important cancer treatment.
Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region (2002)

Several signal transduction pathways have been implicated in the induction of long-term potentiation (LTP), yet the signal transduction mechanisms behind the maintenance-expression phase of LTP are still poorly understood. We investigated the role of phosphatidylinositol 3-kinase (PI3-kinase) in LTP at Schaffer collateral/commissural fiber-CA1 synapses in rat hippocampal slices using biochemical approaches and extracellular electrophysiological recordings. We observed that PI3-kinase activity was induced in the CA1 region during LTP of field EPSPs (fEPSPs) and that two structurally unrelated PI3-kinase inhibitors, LY294002 and wortmannin, abated established LTP, suggesting that PI3-kinase is involved in the maintenance-expression phase of LTP. However, LTP recovered after washout of the reversible PI3-kinase inhibitor LY294002, confirming that LTP maintenance and expression are distinct events and indicating that PI3-kinase activity is required for LTP expression rather than for its maintenance. Interestingly, preincubation with LY294002 did not prevent LTP induction. In fact, if LY294002 was withdrawn 5 min after high-frequency stimulation, an LTP of fEPSP was seen. Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation.
Phase II, Randomized, Double-Blind, Multicenter Study Comparing the Safety and Pharmacokinetics of Tefibazumab to Placebo for Treatment of Staphylococcus aureus Bacteremia (2006)

Tefibazumab (Aurexis), a humanized monoclonal antibody that binds to the surface-expressed adhesion protein clumping factor A, is under development as adjunctive therapy for serious Staphylococcus aureus infections. Sixty patients with documented S. aureus bacteremia (SAB) were randomized and received either tefibazumab at 20 mg/kg of body weight as a single infusion or a placebo in addition to an antibiotic(s). The primary objective of the study was determining safety and pharmacokinetics. An additional objective was to assess activity by a composite clinical end point (CCE). Baseline characteristics were evenly matched between groups. Seventy percent of infections were healthcare associated, and 57% had an SAB-related complication at baseline. There were no differences between the treatment groups in overall adverse clinical events or alterations in laboratory values. Two patients developed serious adverse events that were at least possibly related to tefibazumab; one hypersensitivity reaction was considered definitely related. The tefibazumab plasma half-life was 18 days. Mean plasma levels were <100 microg/ml by day 14. A CCE occurred in six patients (four placebo and two tefibazumab patients) and included five deaths (four placebo and one tefibazumab patient). Progression in the severity of sepsis occurred in four placebo and no tefibazumab patients. Tefibazumab was well tolerated, with a safety profile similar to those of other monoclonal antibodies. Additional trials are warranted to address the dosing range and efficacy of tefibazumab.
Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens. (2003)

Cancer sera contain antibodies which react with a unique group of autologous cellular antigens called tumor-associated antigens (TAAs). This study determines whether a mini-array of multiple TAAs would enhance antibody detection and be a useful approach to cancer detection and diagnosis. The mini-array of TAAs comprised full-length recombinant proteins expressed from cDNAs encoding c-myc, p53, cyclin B1, p62, Koc, IMP1, and survivin. Enzyme immunoassay was used to detect antibodies in 527 sera from six different types of cancer. Antibody frequency to any individual TAA was variable but rarely exceeded 15-20%. With the successive addition of TAAs to a final total of seven antigens, there was a stepwise increase of positive antibody reactions up to a range of 44-68%. Breast, lung, and prostate cancer patients showed separate and distinct profiles of reactivity, suggesting that uniquely constituted antigen mini-arrays might be developed to distinguish between some types of cancer. Distinct antibody profiles were not observed in gastric, colorectal, and hepatocellular carcinomas with this set of seven TAAs. Detection of autoantibodies in cancer can be enhanced by using a mini-array of several TAAs as target antigens. Additional studies in early cancer patients and high-risk individuals and the design of unique antigen panels for different cancers would help to determine whether multiple antigen mini-arrays for the detection of autoantibodies might contribute a clinically useful noninvasive approach to cancer detection and diagnosis.