gebhart/patrepeval huggingface dataset:
Speech, Language, and Hearing in Israel (1993)

No AccessAmerican Journal of Speech-Language PathologyWorld View1 Sep 1993Speech, Language, and Hearing in Israel Richard G. Schwartz, PhD Katherine S. Harris and Tova M. Most Richard G. Schwartz City University of New York, New York City Program in Speech and Hearing Sciences, Graduate School, City University of New York, 33 West 42nd Street, New York, NY 10036. Google Scholar More articles by this author , Katherine S. Harris City University of New York, New York City Google Scholar More articles by this author and Tova M. Most Tel Aviv University, Israel Google Scholar More articles by this author https://doi.org/10.1044/1058-0360.0203.05 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In References Bergman, M., & Reichstein, J. (1971). Speech pathology and audiology in Israel.Asha, 22, 9–12. Google Scholar Additional Resources FiguresReferencesRelatedDetailsCited ByAmerican Journal of Speech-Language Pathology5:3 (4-6)1 Aug 1996Speech-Language Pathology in the Dominican RepublicTimothy Meline, Sonia Peñaló and Adelaida Oréste Volume 2Issue 3September 1993Pages: 5-7 Get Permissions Add to your Mendeley library History Published in issue: Sep 1, 1993 Metrics Downloaded 23 times Topicsasha-topicsasha-article-typesKeywordsinternationalIsraeltrainingaudiologyspeech-language pathologyCopyright & PermissionsCopyright © 1993 American Speech-Language-Hearing AssociationLoading ...
Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 (2009)

Aberrant signaling through G-protein coupled receptors promotes metastasis, the major cause of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a novel suppressor of breast cancer migration and invasion, important steps of metastatic cascades. By blocking signals initiated through G(i)-coupled receptors, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4 disrupted Rac1-dependent lamellipodia formation, a key step involved in cancer migration and invasion. RGS4 has GTPase-activating protein (GAP) activity, which inhibits G-protein coupled receptor signaling by deactivating G-proteins. An RGS4 GAP-deficient mutant failed to inhibit migration and invasion of breast cancer cells in both in vitro assays and a mouse xenograft model. Interestingly, both established breast cancer cell lines and human breast cancer specimens showed that the highest levels of RGS4 protein were expressed in normal breast epithelia and that RGS4 down-regulation by proteasome degradation is an index of breast cancer invasiveness. Proteasome blockade increased endogenous RGS4 protein to levels that markedly inhibit breast cancer cell migration and invasion, which was reversed by an RGS4-targeted short hairpin RNA. Our findings point to the existence of a mechanism for posttranslational regulation of RGS4 function, which may have important implications for the acquisition of a metastatic phenotype by breast cancer cells. Preventing degradation of RGS4 protein should attenuate aberrant signal inputs from multiple G(i)-coupled receptors, thereby retarding the spread of breast cancer cells and making them targets for surgery, radiation, and immune treatment.
Faster laziness using dynamic pointer tagging (2007)

In the light of evidence that Haskell programs compiled by GHC exhibit large numbers of mispredicted branches on modern processors, we re-examine the "tagless" aspect of the STG-machine that GHC uses as its evaluation model. We propose two tagging strategies: a simple strategy called semi-tagging that seeks to avoid one common source of unpredictable indirect jumps, and a more complex strategy called dynamic pointer-tagging that uses the spare low bits in a pointer to encode information about the pointed-to object. Both of these strategies have been implemented and exhaustively measured in the context of a production compiler, GHC, and the paper contains detailed descriptions of the implementations. Our measurements demonstrate significant performance improvements (14% for dynamic pointer-tagging with only a 2% increase in code size), and we further demonstrate that much of the improvement can be attributed to the elimination of mispredicted branch instructions. As part of our investigations we also discovered that one optimisation in the STG-machine, vectored-returns, is no longer worthwhile and we explain why.
Synthesis and Binding to Tubulin of an Allocolchicine Spin Probe. (1981)

A spin probe for the colchicine binding site on tubulin has been synthesized from allocolchicine. The probe is competitive to colchicine with an apparent inhibition constant of 11 microM while allocolchicine has an inhibition constant of 2 microM. Microtubule assembly is inhibited to 50% by 7 microM of the spin probe. As a mitotic poison the spin probe is less potent than colchicine. These data suggest that the probe binds to the same site on tubulin as colchicine and in spite of the somewhat lower efficiency, it seems to be a valuable tool for the study of the microtubule system.
Efficient Multigram Synthesis of the Bifunctional Chelating Agent (S)-1-p-Isothiocyanatobenzyl-diethylenetetraminepentaacetic Acid (2000)

We have developed and optimized the synthesis of the title compound, eliminating all HPLC purifications prior to the final product. The yield (and scale) of the synthesis was increased from 19% (200 mg) to 75% (26 g).
Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats (1991)

We assessed the effect of a 35-day delayed intracerebroventricular (ICV) infusion of epidermal growth factor (EGF) on the survival and function of the substantia nigra (SN) dopaminergic neurons after a unilateral mechanical transection of rat nigrostriatal pathway. EGF infusion for 28 days resulted in a twofold increase in the number of surviving tyrosine-hydroxylase (TH)-positive SN neurons and a significant increase in ipsilateral striatal TH-positive fiber staining compared to controls at 200 days following the injury. In addition, there was a persistent enhancement of behavioral recovery, as indicated by a reduction in amphetamine-induced rotations. We conclude that EGF exerts a neurotrophic effect on the dopaminergic neurons in this experimental model of parkinsonism.
Induction of cytomegalovirus (CMV)–specific T-cell responses using dendritic cells pulsed with CMV antigen: a novel culture system free of live CMV virions (2001)

Recipients of allogeneic transplants are at risk of cytomegalovirus (CMV) infection and disease during the period of immune compromise after transplantation. The limitations of current antiviral pharmacotherapy have led to attempts to develop alternative strategies for preventing or treating CMV infection, such as adoptive transfer of donor-derived virus-specific T cells. Methods for generating CMV-specific T cells either use live CMV to infect autologous antigen-presenting cells (APCs) or require some knowledge of the immunodominant peptides involved in the immune response. A novel culture system was developed that does not use live virions and in which the APCs are monocyte-derived dendritic cells (DCs). APCs were pulsed with CMV antigen and cocultured with autologous peripheral blood lymphocytes from donors seropositive for CMV. The culture-output cells consisted of both CD4- and CD8-expressing T cells. Proliferation, as determined by a tritium-thymidine-incorporation assay, showed significant CMV-antigen specificity in cultures from 15 of 15 donors seropositive for CMV. In cytotoxicity assays, cytotoxic T lymphocytes from 10 of 12 cocultures specifically lysed autologous CMV-infected fibroblasts or DCs but not HLA-mismatched or uninfected target cells, and this activity was shown to be blocked by HLA class 1 blocking antibodies. T-cell-receptor spectratyping of cells from the cultures typically showed complex size-distribution patterns, with all size classes of a normal preculture distribution present. However, a few size-class peaks were expanded compared with the preculture patterns and these may have represented expansions of CMV-specific T-cell clones. Advantages of this culture system are that it requires no live virions and no detailed knowledge of the antigenic peptides involved and it is applicable to CMV-seropositive donors of any HLA type.
Severe Hypercholesterolemia in Four British Families With the D374Y Mutation in the PCSK9 Gene (2005)

These British PCSK9 patients with the D374Y mutation have an unpredictably severe clinical phenotype, which may be a unique feature for this cohort, and requires early and aggressive lipid-lowering management to prevent cardiovascular complications.
Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function (2003)

Cell-to-cell communication during development and plasticity is controlled to a large extent by signaling events downstream of receptor tyrosine kinases (RTKs). Most RTKs bind soluble ligands, which are often produced at a distance from the RTK-expressing cells, and therefore these interactions typically mediate long-range communication. Eph receptors (or Ephs), instead, bind membrane-bound ephrin ligands expressed by neighboring cells and mediate short-range cell-to-cell communication. The influence of ephrin–Eph interaction on cell behavior depends on the cell type, but can in most cases be interpreted as repulsion of neighboring cells or of cellular processes, such as the neuronal growth cone. However, in some cases ephrin–Eph activation can have the opposite effect, that is, increased adhesion/attraction. One subclass of ephrins, the ephrinB ligands, are transmembrane proteins with intrinsic (so-called reverse) signaling properties (for review, see Kullander and Klein 2002). This complicates the interpretation of functional assays and genetic phenotypes, because manipulations intended to eliminate forward receptor function often have consequences for reverse signaling as well. This review summarizes the diverse biological roles of ephrins and Ephs in embryonic development, including patterning and morphogenetic processes of the nervous and vascular systems, and in the adult, such as synaptic plasticity. We further touch upon more recent observations on ephrin functions in neurogenesis, nervous system regeneration, and tumorigenesis. Our focus is on, but is not restricted to, recent findings using genetically amenable systems.
CDC Update on Pertussis Surveillance and Tdap Vaccine Recommendations (2012)

Pertussis is the most poorly controlled bacterial vaccine-preventable disease. Since the early 1980s there has been an increase in reported cases of pertussis. Multiple factors have likely contributed to the increase, including waning immunity, increased recognition, and changes in diagnostic testing and reporting. Of the four combination vaccines used to prevent diphtheria, tetanus, and pertussis, one dose of Tdap should be used to vaccinate preteens as well as teens and adults who have not yet received this booster dose. It is the position of NASN that immunizations, including the Tdap vaccine, are key to primary prevention of diseasefrom infancy through adulthood. The school nurse is in a critical position to create awareness and influence action-related national and state recommendations for the Tdap vaccine.
Cultivar Responses to Sudden Death Syndrome of Soybean (1991)

Forty-two soybean (Glycine max) cultivars representing maturity groups IV-VIII were evaluated for their response to sudden death syndrome (SDS), caused by Fusarium solani, over 3 yr in a field with a history of the disease. Disease severity was assessed weekly from the middle of July through September using a rating scale of 0-5 where 0=0%, 1=1-10%, 2=11-30%, 3=31-70%, 4=71-90%, and 5=>90% of the leaf area exhibiting foliar symptoms of SDS. Area under the disease progress curve was calculated for each cultivar(.)
Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects (2006)

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
A non-hydrolytic route to organically-modified silica (1999)

A versatile route to organic–inorganic hybrid nanocomposite materials is described, where organically modified silicon halides and alkoxides are reacted together in a solvent-free non-hydrolytic sol–gel process.
Sparse Learning via Iterative Minimization With Application to MIMO Radar Imaging (2010)

Through waveform diversity, multiple-input multiple-output (MIMO) radar can provide higher resolution, improved sensitivity, and increased parameter identifiability compared to more traditional phased-array radar schemes. Existing methods for target estimation, however, often fail to provide accurate MIMO angle-range-Doppler images when there are only a few data snapshots available. Sparse signal recovery algorithms, including many <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$l_{1}$</tex></formula> -norm based approaches, can offer improved estimation in that case. In this paper, we present a regularized minimization approach to sparse signal recovery. Sparse learning via iterative minimization (SLIM) follows an <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$l_{q}$</tex></formula> -norm constraint (for <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$0&lt;q\leq 1$</tex></formula> ), and can thus be used to provide more accurate estimates compared to the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$l_{1}$</tex></formula> -norm based approaches. We herein compare SLIM, through imaging examples and examination of computational complexity, to several well-known sparse methods, including the widely used CoSaMP approach. We show that SLIM provides superior performance for sparse MIMO radar imaging applications at a low computational cost. Furthermore, we will show that the user parameter <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$q$</tex></formula> can be automatically determined by incorporating the Bayesian information criterion.
Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein. (1989)

In H-2d mice, the immunodominant determinant of the HIV-1-IIIB gp160 envelope glycoprotein recognized by CD8+ CTL is represented by a 15-residue synthetic peptide (315-329: RIQRGPGRAFVTIGK). This peptide is seen in association with the Dd class I MHC molecule expressed on H-2k L cell fibroblast targets. We explored the structural requirements for CTL recognition of this peptide at the levels of both the peptide molecule and the class I MHC molecule. Using several transfectants expressing recombinant Dd/Ld molecules, we found that presentation of this epitope required both the alpha 1 and alpha 2 domains of the Dd molecule, in contrast to certain instances of allorecognition for which alpha 1 of Dd was sufficient in association with alpha 2 of Ld. Because this peptide derives from a hypervariable segment of the HIV envelope, substituted peptides could be used to define not only the structures affecting interaction of peptide with class I MHC molecule and with the TCR, but also the structural basis for the effect of naturally occurring viral variation on CTL recognition. The CTL-LINE specific for this HIV-1-IIIB-derived sequence could not recognize the HIV-1-RF variant-derived sequence from exactly the same site (315-329:--HIGPGRVIYATGQ). Peptides with single amino acid substitutions from the HIV-1-IIIB sequence toward the HIV-1-RF sequence were made to test the effect of each residue significantly affected recognition, and only one, 324(F), was obligatory. Moreover, both 322(R) and 324(F) substituted peptides failed to inhibit the binding of the wild type peptide to the MHC molecule. Therefore, the amino-acids 322(R) and 324(F) seem to be involved in regulating peptide interaction with the Dd class I MHC molecule. In contrast, 325(V) appeared to affect interaction with the TCR. We suggest that sequence variations among known HIV-1 isolates that affect peptide binding to MHC such as those described here, if occurring during the course of infection of an individual, could result in failure of the MHC molecules of that individual to present the peptide. If the number of dominant HIV CTL epitopes is indeed very limited, such a blind spot could allow the virus to escape immune control, proliferate rapidly, and cause AIDS.
Ultra fast write speed, long refresh time, low power F-N operated volatile memory cell with stacked nanocrystalline Si film (2002)

A new volatile memory structure with nanocrystalline Si layer and auxiliary floating polysilicon gate is reported. The charges are injected through tunnel oxide and nanocrystalline Si layer by FN tunneling and then stored in this stacked structure. The nanocrystalline Si layer with extended floating gate structure improves the limited charge storage volume, leads to a memory device with distinct threshold voltage window, and improves programming speed during FN operation. Based on the merit of low power F-N operation, high write speed, long refresh time and compatible CMOS process, this device is feasible for DRAM application.
Deletion of fucose residues in plant N ‐glycans by repression of the GDP‐mannose 4,6‐dehydratase gene using virus‐induced gene silencing and RNA interference (2010)

Production of pharmaceutical glycoproteins in plants has many advantages in terms of safety and reduced costs. However, plant-produced glycoproteins have N-glycans with plant-specific sugar residues (core β-1,2-xylose and α-1,3-fucose) and a Lewis a (Le(a) ) epitope, i.e., Galβ(1-3)[Fucα(1-4)]GlcNAc. Because these sugar residues and glycan structures seemed to be immunogenic, several attempts have been made to delete them by repressing their respective glycosyltransferase genes. However, until date, such deletions have not been successful in completely eliminating the fucose residues. In this study, we simultaneously reduced the plant-specific core α-1,3-fucose and α-1,4-fucose residues in the Le(a) epitopes by repressing the Guanosine 5'-diphosphate (GDP)-D-mannose 4,6-dehydratase (GMD) gene, which is associated with GDP-L-fucose biosynthesis, in Nicotiana benthamiana plants. Repression of GMD was achieved using virus-induced gene silencing (VIGS) and RNA interference (RNAi). The proportion of fucose-free N-glycans found in total soluble protein from GMD gene-repressed plants increased by 80% and 95% following VIGS and RNAi, respectively, compared to wild-type plants. A small amount of putative galactose substitution in N-glycans from the NbGMD gene-repressed plants was observed, similar to what has been previously reported GMD-knockout Arabidopsis mutant. On the other hand, the recombinant mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) with fucose-deleted N-glycans was successfully produced in NbGMD-RNAi transgenic N. benthamiana plants. Thus, repression of the GMD gene is thus very useful for deleting immunogenic total fucose residues and facilitating the production of pharmaceutical glycoproteins in plants.
Determination of Gangliosides in Six Human Primary Medulloblastomas (1990)

The ganglioside composition of six human medulloblastomas was analyzed. The characterization was performed by thin-layer chromatography, sialidase hydrolysis, and immunological staining with a panel of characterized antiganglioside monoclonal antibodies. The total ganglioside content ranged from 60 to 1,130 nmol of ganglioside sialic acid/g wet weight. Neuronal gangliosides (gangliotetraose series) were found in varying amounts in all medulloblastomas. Gangliosides of the neolactotetraose series (3'-LM1 and LD1) were present in all specimens, and the lactotetraose series ganglioside 3'-isoLM1 was found in all cases showing astrocytic differentiation. This supports our previous findings that 3'-isoLM1 is a marker for proliferating astroglial cells.
Molecular biology and genetics of Alzheimer's disease (2005)

Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have identified four genes associated with inherited risk for AD (presenilin 1, presenilin 2, amyloid precursor protein, and apolipoprotein E). These genes account for about half of the total genetic risk for Alzheimer's disease. It is suspected that several other Alzheimer's disease-susceptibility genes exist, and their identification is the subject of ongoing research. Nevertheless, biological studies on the effects of mutations in the four known genes has led to the conclusion that all of these genes cause dysregulation of amyloid precursor protein processing and in particular dysregulation of the handling of a proteolytic derivative termed Abeta. The accumulation of Abeta appears to be an early and initiating event that triggers a series of downstream processes including misprocessing of the tau protein. This cascade ultimately causes neuronal dysfunction and death, and leads to the clinical and pathological features of Alzheimer's disease. Knowledge of this biochemical cascade now provides several potential targets for the development of diagnostics and therapeutics.
Aux/IAA proteins repress expression of reporter genes containing natural and highly active synthetic auxin response elements. (1997)

A highly active synthetic auxin response element (AuxRE), referred to as DR5, was created by performing site-directed mutations in a natural composite AuxRE found in the soybean GH3 promoter. DR5 consisted of tandem direct repeats of 11 bp that included the auxin-responsive TGTCTC element. The DR5 AuxRE showed greater auxin responsiveness than a natural composite AuxRE and the GH3 promoter when assayed by transient expression in carrot protoplasts or in stably transformed Arabidopsis seedlings, and it provides a useful reporter gene for studying auxin-responsive transcription in wild-type plants and mutants. An auxin response transcription factor, ARF1, bound with specificity to the DR5 AuxRE in vitro and interacted with Aux/IAA proteins in a yeast two-hybrid system. Cotransfection experiments with natural and synthetic AuxRE reporter genes and effector genes encoding Aux/IAA proteins showed that overexpression of Aux/IAA proteins in carrot protoplasts resulted in specific repression of TGTCTC AuxRE reporter gene expression.