gebhart/patrepeval huggingface dataset:
Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. (1994)

The cultured T-cell line TIL1200, established from the tumor-infiltrating lymphocytes (TILs) of a patient with advanced metastatic melanoma, recognized an antigen on most HLA-A2+ melanomas and on all HLA-A2+ cultured neonatal melanocytes in an HLA-A2 restricted manner but not on other types of tissues or cell lines tested. A cDNA encoding an antigen recognized by TIL1200 was isolated by screening an HLA-A2+ breast cancer cell line transfected with an expression cDNA library prepared from an HLA-A2+ melanoma cell line. The nucleotide and amino acid sequences of this cDNA were almost identical to the genes encoding glycoprotein gp100 or Pmel17 previously registered in the GenBank. Expression of this gene was restricted to melanoma and melanocyte cell lines and retina but was not expressed on other fresh or cultured normal tissues or other types of tumor tested. The cell line transfected with this cDNA also expressed antigen recognized by the melanoma-specific antibody HMB45 that bound to gp100. A synthetic 10-amino acid peptide derived from gp100 was recognized by TIL1200 in the context of HLA-A2.1. Since the administration of TIL1200 plus interleukin 2 resulted in regression of metastatic cancer in the autologous patient, gp100 is a possible tumor rejection antigen and may be useful for the development of immunotherapies for patients with melanoma.
A Scalable Video Coding Extension of HEVC (2013)

The paper describes a scalable video coding extension of the upcoming HEVC video coding standard for spatial and quality scalable coding. Besides coding tools known from scalable profiles of prior video coding standards, it includes new coding tools that further improve the enhancement layer coding efficiency. The effectiveness of the proposed scalable HEVC extension is demonstrated by comparing the coding efficiency to simulcast and single-layer coding for several test sequences and coding conditions.
Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray (2009)

Micro RNAs (miRNAs) are a class of small, non-coding RNA species that play critical roles throughout cellular development and regulation. miRNA expression patterns taken from various tissue types often point to the cellular lineage of an individual tissue type, thereby being a more invariant hallmark of tissue type. Recent work has shown that these miRNA expression patterns can be used to classify tumor cells, and that this classification can be more accurate than the classification achieved by using messenger RNA gene expression patterns. One aspect of miRNA biogenesis that makes them particularly attractive as a biomarker is the fact that they are maintained in a protected state in serum and plasma, thus allowing the detection of miRNA expression patterns directly from serum. This study is focused on the evaluation of miRNA expression patterns in human serum for five types of human cancer, prostate, colon, ovarian, breast and lung, using a pan-human microRNA, high density microarray. This microarray platform enables the simultaneous analysis of all human microRNAs by either fluorescent or electrochemical signals, and can be easily redesigned to include newly identified miRNAs. We show that sufficient miRNAs are present in one milliliter of serum to detect miRNA expression patterns, without the need for amplification techniques. In addition, we are able to use these expression patterns to correctly discriminate between normal and cancer patient samples.
Electric-field driven jetting from dielectric liquids (2004)

Three dielectric (electrical conductivity ∼10−13Sm−1) Newtonian liquids with viscosity in the range 1–100 mPa s were passed through a needle at a controlled flow rate under the influence of an electric field. At an electric field strength of 1.5kV∕mm, the liquid exiting the needle instantaneously transformed from dripping droplets to an elliptically pendent droplet from the apex of which a fine jet evolved. Thus, a jet can be obtained on demand, and in this letter we define this phenomenon and explain a basis for it.
A NEW PARADIGM FOR PARTNERSHIPS. (1994)

8 ASUBTITLE: GOODYEAR USED TO PLAY HARDBALL WHEN IT CAME TO RATE NEGOTIATIONS: TODAY, THE COMPANY DOESN'T PLAY GAMES, IT DOES BUSINESS.
Bubble population measurements with a parametric array (1994)

This paper presents a method that estimates gas bubble density in water versus range. A bubble cloud being insonified with a highly directive acoustic transducer, this method combines backscattering and attenuation measurements. It relies on the linear theory of bubble resonance, and the so-called first-order multiple scattering approximation. Here it is applied to some measurements performed with a parametric array (primary frequency: 210 kHz; secondary: 8 to 40 kHz). The application of this method to the secondary frequencies fails, because the backscattered levels are much higher than the saturation level. This failure is imputed to the nonlinear scattering occurring at the secondary frequencies by the bubbles whose resonance is close to the primary frequency. From this assumption, minimum ranges are deduced under which the measurements of bubbles resonating at the secondary frequencies cannot be stated as reliable.
Prediction-Based Power-Performance Adaptation of Multithreaded Scientific Codes (2008)

Computing has recently reached an inflection point with the introduction of multi-core processors. On-chip thread-level parallelism is doubling approximately every other year. Concurrency lends itself naturally to allowing a program to trade performance for power savings by regulating the number of active cores, however in several domains users are unwilling to sacrifice performance to save power. We present a prediction model for identifying energy-efficient operating points of concurrency in well-tuned multithreaded scientific applications, and a runtime system which uses live program analysis to optimize applications dynamically. We describe a dynamic, phase-aware performance prediction model that combines multivariate regression techniques with runtime analysis of data collected from hardware event counters to locate optimal operating points of concurrency. Using our model, we develop a prediction-driven, phase-aware runtime optimization scheme that throttles concurrency so that power consumption can be reduced and performance can be set at the knee of the scalability curve of each program phase. The use of prediction reduces the overhead of searching the optimization space while achieving near-optimal performance and power savings. A thorough evaluation of our approach shows a reduction in power consumption of 10.8% simultaneous with an improvement in performance of 17.9%, resulting in energy savings of 26.7%.
Tutorial On Advances In Morphological Image Processing And Analysis (1987)

This paper reviews some recent advances in the theory and applications of morphological image analysis. Regarding applications, we show how the morphological filters can be used to provide simple and systematic algorithms for image processing and analysis tasks as diverse as nonlinear image filtering, noise suppression, edge detection, region filling, skeletonization, coding, shape representation, smoothing, and recognition. Regarding theory, we summarize the representation of a large class of translation-invariant nonlinear filters (including morphological, median, order-statistic, and shape recognition filters) as a minimal combination of morphological erosions or dilations; these results provide new realizations of these filters and lead to a unified image algebra.
Hybrid Solar Cells from Regioregular Polythiophene and ZnO Nanoparticles (2006)

Abstract Blends of nanocrystalline zinc oxide nanoparticles (nc‐ZnO) and regioregular poly(3‐hexylthiophene) (P3HT) processed from solution have been used to construct hybrid polymer–metal oxide bulk‐heterojunction solar cells. Thermal annealing of the spin‐cast films significantly improves the solar‐energy conversion efficiency of these hybrid solar cells to ∼ 0.9 %. Photoluminescence and photoinduced absorption spectroscopy demonstrate that charge‐carrier generation is not quantitative, because a fraction of P3HT appears not to be in contact with or in close proximity to ZnO. The coarse morphology of the films, also identified by tapping‐mode atomic force microscopy, likely limits the device performance.
Permanently Linked Monodisperse Paramagnetic Chains (1998)

Here we present a method for synthesizing permanently linked monodisperse paramagnetic chains by both covalently linking surface-functionalized polystyrene particles and physically linking electrostatically stabilized paramagnetic emulsion droplets. We observe the stability, field alignment, and flexibility of this new class of materials. These anisotropic magnetoresponsive materials should be of interest for their unique rheological, optical, electronic, and micromechanical properties.
Characterization of human ovarian carcinoma‐associated antigens defined by novel monoclonal antibodies with tumor‐restricted specificity (1987)

Three new monoclonal antibodies (MAbs) (MOv16, MOv18 and MOv19) were raised against human ovarian carcinoma. To obtain more specific reagents than those produced so far, we adopted the following experimental approach which consisted of: the selection of a poorly differentiated ovarian carcinoma which was unreactive with all the MAb previously selected in our laboratory; and the application of a particular immunization protocol. The reactivity of the selected MAbs was studied by solid-phase RIA on live and fixed cells from tumor cell lines and by immunofluorescence on frozen sections from surgical specimens. The MAb MOv16 reacted with 60% of ovarian carcinomas as well as with a high percentage of other carcinomas and with some normal tissues. In contrast, MOv18 and MOv19 appeared to have restricted specificities for ovarian carcinomas and cystadenomas. Reactivity on other carcinomas was only observed in a few cases and no reactivity was found on non-epithelial tumors or normal tissues. Immunoprecipitation experiments indicated that MOv16 recognizes a 48-50-kDA protein, whereas MOv18 and MOv19 both identify a 38-40 kDA glycoprotein band. Cross-competition experiments, together with a double-determinant immunoradiometric assay which uses MOv18 as catcher and MOv19 as tracer, suggested that they recognize different epitopes carried by the same molecule. The affinity constants of MOv18 and MOv19 were estimated to be in the range of 10(8)-10(9) M-1. Taken together, the properties of these antibodies, their restricted ovarian tumor specificities and relative high affinity constants, suggest that they could represent promising tools for in vivo applications.
Tetrahydrobiopterin biosynthesis, regeneration and functions (2000)

Tetrahydrobiopterin (BH(4)) cofactor is essential for various processes, and is present in probably every cell or tissue of higher organisms. BH(4) is required for various enzyme activities, and for less defined functions at the cellular level. The pathway for the de novo biosynthesis of BH(4) from GTP involves GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase and sepiapterin reductase. Cofactor regeneration requires pterin-4a-carbinolamine dehydratase and dihydropteridine reductase. Based on gene cloning, recombinant expression, mutagenesis studies, structural analysis of crystals and NMR studies, reaction mechanisms for the biosynthetic and recycling enzymes were proposed. With regard to the regulation of cofactor biosynthesis, the major controlling point is GTP cyclohydrolase I, the expression of which may be under the control of cytokine induction. In the liver at least, activity is inhibited by BH(4), but stimulated by phenylalanine through the GTP cyclohydrolase I feedback regulatory protein. The enzymes that depend on BH(4) are the phenylalanine, tyrosine and tryptophan hydroxylases, the latter two being the rate-limiting enzymes for catecholamine and 5-hydroxytryptamine (serotonin) biosynthesis, all NO synthase isoforms and the glyceryl-ether mono-oxygenase. On a cellular level, BH(4) has been found to be a growth or proliferation factor for Crithidia fasciculata, haemopoietic cells and various mammalian cell lines. In the nervous system, BH(4) is a self-protecting factor for NO, or a general neuroprotecting factor via the NO synthase pathway, and has neurotransmitter-releasing function. With regard to human disease, BH(4) deficiency due to autosomal recessive mutations in all enzymes (except sepiapterin reductase) have been described as a cause of hyperphenylalaninaemia. Furthermore, several neurological diseases, including Dopa-responsive dystonia, but also Alzheimer's disease, Parkinson's disease, autism and depression, have been suggested to be a consequence of restricted cofactor availability.
Automated Tape Laying (2001)

Abstract Automated tape laying is a mature process used in both commercial and military aircraft applications. This article provides a brief history of the process and describes the use of commercially available flat and contour tape-laying equipment. It discusses the advantages and disadvantages of the tape laying. The article describes the various components of a ten-axis gantry-type tape laying machine and the tape laying process. It provides a discussion on typical material types and forms for tape laying and provides information on design guidelines for tape laying.
Acoustic echo cancellation using subband technique for teleconferencing applications (2002)

In acoustic echo cancellation, the conventional adaptive FIR filter can have many taps, resulting in a large computational complexity and slow convergence of the algorithm. Multi-rate techniques can be used to overcome these disadvantages by adapting several shorter filters in subbands at a reduced rate. However, the down sampling process introduces aliased version of the original signals, especially when signals are critically down sampled. In this paper, the nonoverlapping filter banks with decimated auxiliary subbands are employed to alleviate distortion due to aliasing and spectral gaps, while a low computational load is maintained.
Technology evaluation: pegaptanib, Eyetech/Pfizer. (2003)

Eyetech Pharmaceuticals and Pfizer are co-developing the anti-vascular endothelial growth factor aptamer, pegaptanib, as an angiogenesis inhibitor for the potential treatment of age-related macular degeneration and diabetic macular edema, in addition to other ocular diseases. Gilead was previously investigating the aptamer for the potential treatment of cancer, however, no data have been published for this indication since 1999.
Survey on the provision and demand of elderly-care unit in a community health service centre of Shanghai (2010)

The provision and demand of elderly-care unit in a community health service center was surveyed by questionnaire and enquiry on focus group. The study items included human resource and service type, condition of caring workers and demander. Results showed that the main service type of elderly-care unit was medical service, which accounted for 82. 6% of the total cost The average activity of daily life score of patients was 25, and nursing was the main needs of patients. The quality and quantity of nursing staff was relatively low, which impedes the provision of the service, so social caring should be encouraged to overcome the obstacles.

Key words: 
Geriatric nursing;  Community health service
Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B and Other Diketopiperazines Produced by Aspergillus fumigatus. II. Physico-chemical Properties and Structures. (1996)

Two novel diketopiperazines named tryprostatins A and B and a new natural product belonging to the diketopiperazine series, designated as demethoxyfumitremorgin C, together with four known diketopiperazines, fumitremorgin C, 12,13-dihydroxyfumitremorgin C, fumitremorgin B and verruculogen, are new M phase inhibitors of the mammalian cell cycle, which were isolated from the secondary metabolites of Aspergillus fumigatus. The structures of tryprostatins A, B and demethoxyfumitremorgin C were determined mainly by the use of spectroscopic methods especially by detailed analyses of their 1H and 13C NMR spectra with the aid of 2D NMR techniques including pulse field gradient heteronuclear multiple-bond correlation (PFG-HMBC) spectroscopy. Their absolute configurations were determined on the basis of the optical rotational values and CD spectra.
Crosslinked acrylic pressure‐sensitive adhesives. I. Effect of the crosslinking reaction on the peel strength (2002)

Abstract For pressure‐sensitive adhesives (PSAs) composed of poly( co ‐ethyl acrylate‐2‐ethylhexyl acrylate‐2‐hydroxyethyl methacrylate) as a base resin and polyisocyanate as a crosslinker, the relationship between the crosslinking reaction and peel strength was investigated. A 90° peel test of cured PSA films under various storage conditions was carried out. At the same time, the isocyanate (NCO) consumption in these PSA films was monitored by attenuated total reflectance/Fourier transform infrared spectroscopy. The peel strength of the PSA compounded with the crosslinker decreased as the NCO groups were consumed. The elevation of the aging temperature promoted the crosslinking reaction and increased the decrement in the peel strength. The peel strength of noncrosslinked and crosslinked PSA films increased with the contact time. A high storage temperature made the increment in the peel strength increase. The addition of the crosslinker to the PSA films reduced the increment in the peel strength. Furthermore, PSA films with residual NCO groups possessed stronger peel strengths than fully cured films. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1493–1499, 2003
Live Lactobacillus reuteri Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression (2004)

The mechanism of the apparent anti-inflammatory action of probiotic organisms is unclear. Lactobacillus reuteri is effective in inhibiting colitis in interleukin-10 (IL-10)-deficient mice. Nerve growth factor (NGF), in addition to its activity on neuronal cell growth, has significant anti-inflammatory effects in several experimental systems in vitro and in vivo, including a model of colitis. Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and NGF synthesis and IL-8 response to tumor necrosis factor alpha (TNF-alpha). Epithelial cells were cultured for various times with live and killed L. reuteri and examined by reverse transcription-PCR for NGF, IL-10, and TNF-alpha-induced IL-8 expression. An enzyme-linked immunosorbent assay was used to quantitate intracellular IL-8 and secreted product. Western blotting and confocal microscopy were used to determine the effects on IkappaB and NF-kappaB, respectively. Live but not heat-killed or gamma-irradiated L. reuteri upregulated NGF and dose dependently inhibited constitutive synthesis by T84 and HT29 cells of IL-8 and that induced by TNF-alpha in terms of mRNA and intracellular and secreted protein. Similarly, L. reuteri inhibited IL-8 synthesis induced by Salmonella enterica serovar Typhimurium. L. reuteri required preincubation and adherence for effect, inhibited translocation of NF-kappaB to the nuclei of HeLa cells, and prevented degradation of IkappaB. Neither cellular lysates nor media supernatants had any effect on TNF-alpha-induced IL-8. The conclusion is that L. reuteri has potent direct anti-inflammatory activity on human epithelial cells, which is likely to be related to the activity of ingested probiotics. L. reuteri also upregulates an unusual anti-inflammatory molecule, NGF, and inhibits NF-kappaB translocation to the nucleus.
Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease (2014)

Nonalcoholic fatty liver disease (NAFLD) is characterized by a massive accumulation of lipid droplets (LDs). The aim of this study was to determine the function of 17β-hydroxysteroid dehydrogenase-13 (17β-HSD13), one of our newly identified LD-associated proteins in human subjects with normal liver histology and simple steatosis, in NAFLD development. LDs were isolated from 21 human liver biopsies, including 9 cases with normal liver histology (group 1) and 12 cases with simple steatosis (group 2). A complete set of LD-associated proteins from three liver samples of group 1 or group 2 were determined by 2D LC-MS/MS. By comparing the LD-associated protein profiles between subjects with or without NAFLD, 54 up-regulated and 35 down-regulated LD-associated proteins were found in NAFLD patients. Among them, 17β-HSD13 represents a previously unidentified LD-associated protein with a significant up-regulation in NAFLD. Because the 17β-HSD family plays an important role in lipid metabolism, 17β-HSD13 was selected for validating the proteomic findings and exploring its role in the pathogenesis of NAFLD. Increased hepatic 17β-HSD13 and its LD surface location were confirmed in db/db (diabetic) and high-fat diet-fed mice. Adenovirus-mediated hepatic overexpression of human 17β-HSD13 induced a fatty liver phenotype in C57BL/6 mice, with a significant increase in mature sterol regulatory element-binding protein 1 and fatty acid synthase levels. The present study reports an extensive set of human liver LD proteins and an array of proteins differentially expressed in human NAFLD. We also identified 17β-HSD13 as a pathogenic protein in the development of NAFLD.
Bar code tracking system enhances record- and film-handling productivity. (1992)

The bar coding system has proven to be highly successful. Use of the bar code label has already been added to the dictation system in medical record and medical imaging services departments for entry of patient identification of each dictated report. Other system enhancements under consideration include tracking ancillary department reports as they are forwarded to the medical record department for storage in the permanent patient record and tracking individual volumes of a patient's medical record.
Cell-specific enhancer activity in a far upstream region of the human alpha-fetoprotein gene. (1987)

We describe experiments showing that the 5'-flanking region of the human alpha-fetoprotein (AFP) gene contains transcription control elements with characteristics of enhancers. The enhancer activity was detected and characterized by the ability to direct the expression of a linked chloramphenicol acetyltransferase (CAT) gene in transfected AFP-producing hepatoma cells in culture. The enhancer activity is cell-specific in that it occurs in hepatoma cells producing AFP, but not in non-AFP-producing hepatoma or nonhepatic cells. The active elements can direct CAT expression in conjunction with the SV40 promoter in an orientation- and position-independent manner. The sequences important for enhancer activity reside in the 400-base pair region between 3.3 and 3.7 kilobase pairs upstream of the AFP gene. This and proximal upstream regions contain multiple enhancer "core"-like sequences and other stretches of potential biological significance.
UltraSPARC-III: designing third-generation 64-bit performance (1999)

The UltraSPARC-III is the third generation of Sun Microsystems' most powerful microprocessors, which are at the heart of Sun's computer systems. These systems, ranging from desktop workstations to large, mission critical servers, require the highest performance that the UltraSPARC line has to offer. The newest design permits vendors the scalability to build systems consisting of 1,000+ UltraSPARC processors. Furthermore, the design ensures compatibility with all existing SPARC applications and the Solaris operating system. The UltraSPARC-III design extends Sun's SPARC Version 9 architecture, a 64-bit extension to the original 32-bit SPARC architecture that traces its roots to the Berkeley RISC-I processor. The UltraSPARC-III design target is a 600-MHz, 70-watt, 13-mm die to be built in 0.25-micron CMOS with six metal layers for signals, clocks, and power.