gebhart/patrepeval huggingface dataset:
Dynamic resonant peak locking scheme for diode laser modulation spectroscopy (1993)

We describe a diode laser frequency control scheme that dynamically locks the laser to an absorption resonance line while simultaneously allowing the quantitative measure of absorption strengths as weak as a few parts in 10<sup>6</sup>. The method exploits a novel modulation scheme, and is capable of locking the laser to both stable and transient species in an electrically noisy environment such as that found in plasma etching reactors. We present an experimental demonstration using a lead salt diode laser operating near an rt plasma etching diode reactor and in an industrial-type triode reactor.
Controlled Radical Polymerization in the Presence of Oxygen (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorControlled Radical Polymerization in the Presence of OxygenKrzysztof Matyjaszewski, Simion Coca, Scott G. Gaynor, Mingli Wei, and Brian E. WoodworthView Author Information Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213 Cite this: Macromolecules 1998, 31, 17, 5967–5969Publication Date (Web):August 6, 1998Publication History Received29 May 1998Revised2 July 1998Published online6 August 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/ma9808528https://doi.org/10.1021/ma9808528rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1671Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Living polymerization,Organic compounds,Oxygen,Polymerization,Radical polymerization Get e-Alerts
PICKLE is a CHD3 chromatin-remodeling factor that regulates the transition from embryonic to vegetative development in Arabidopsis (1999)

The life cycle of angiosperms is punctuated by a dormant phase that separates embryonic and postembryonic development of the sporophyte. In the pickle (pkl) mutant of Arabidopsis, embryonic traits are expressed after germination. The penetrance of the pkl phenotype is strongly enhanced by inhibitors of gibberellin biosynthesis. Map-based cloning of the PKL locus revealed that it encodes a CHD3 protein. CHD3 proteins have been implicated as chromatin-remodeling factors involved in repression of transcription. PKL is necessary for repression of LEC1, a gene implicated as a critical activator of embryo development. We propose that PKL is a component of a gibberellin-modulated developmental switch that functions during germination to prevent reexpression of the embryonic developmental state.
Effects of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor on Thrombocytopenia Induced by a New Myelosuppressive Chemotherapy Regimen in Mice (1996)

Thrombopoietin, the endogenous c-Mpl ligand, is a novel lineage-specific hematopoietic factor that plays a pivotal role in the regulation of megakaryocytopoiesis and thrombopoiesis. In this study, we examined the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a truncated molecule of recombinant human c-Mpl ligand derivatized with polyethylene glycol, on myelosuppressive chemotherapy-induced thrombocytopenia in mice. We developed a new murine model of thrombocytopenia induced by i.v. injections of mitomycin C (MMC) for two consecutive days. In control mice, platelet counts began to decrease on day 6, reached a nadir of less than 5% of basal level on day 14, and could not recover to basal level by day 26. Administration of PEG-rHuMGDF greatly enhanced recovery of the number of megakaryocyte progenitor cells and the megakaryocytes in bone marrow, and markedly reduced the severity of thrombocytopenia; it also accelerated platelet recovery in a dose-dependent manner in myelosuppressed mice. Mice receiving consecutive administration of higher doses of PEG-rHuMGDF showed no thrombocytopenia but rather had platelet counts being increased over basal level. Although absolute neutrophil counts and red cell counts also were decreased following MMC treatment, administration of PEG-rHuMGDF also improved neutropenia and anemia. Administration of PEG-rHuMGDF on alternate days or once a week after chemotherapy was almost as effective as consecutive administration in improving thrombocytopenia. Combined administration of PEG-rHuMGDF and rHuG-CSF had an additive effect on improvement of thrombocytopenia and neutropenia. These results suggest that PEG-rHuMGDF is a therapeutically effective agent in the treatment of thrombocytopenia associated with chemotherapy.
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver. (1999)

Cytochrome P450 (CYP) 2A6 is an important enzyme catalysing the metabolism of many drugs, procarcinogens and promutagens. Its role in human liver metabolism of coumarin, 4-nitroanisole, 4-nitrophenol and 7-ethoxycoumarin was analysed with an inhibitory monoclonal antibody (MAb) to CYP2A6. MAbs were derived from a panel of 16 hybridomas which yielded positive enzyme-linked immunosorbent assay (ELISA) results or immunoblots against CYP2A6. The hybridomas were selected from more than 500 clones generated by the fusion of myeloma cells with spleen cells of mice immunized with purified baculovirus-expressed human CYP2A6. The MAbs obtained from four of the 16 hybridomas exhibited strong inhibitory activity to CYP2A6-catalysed phenanthrene metabolism. MAb 151-45-4 was positive and highly specific to CYP2A6 as determined by ELISA and immunoblot, and showed no cross-reactivity with recombinant human CYP 1A1, 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4 and 3A5, as tested with ELISA and immunoblot analyses. MAb 151-45-4 specifically inhibited CYP2A6-catalysed metabolism of phenanthrene, 4-nitroanisole, 4-nitrophenol, coumarin and 7-ethoxycoumarin each by 94-99% and did not inhibit their metabolism catalysed by 10 other human CYPs. The potent inhibitory effect of MAb 151-45-4 was used to define the contribution of human CYP2A6 to the metabolism of coumarin, 4-nitroanisole and 7-ethoxycoumarin in seven human liver microsome samples. Coumarin metabolism in all of the seven samples was inhibited by greater than 94% by MAb 151-45-4 which indicates that essentially all microsome mediated coumarin metabolism in human liver is catalysed only by CYP2A6. Inhibition of 4-nitroanisole and 7-ethoxycoumarin metabolism by anti 2A6 MAb ranged from 22-65% and 8-24%, respectively. The degree of inhibition defines the contribution of CYP2A6 activity to the 4-nitroanisole and 7-ethoxycoumarin metabolism in human liver and the range reflects the variability among samples. The inhibitory antibody to CYP2E1 was used to determine its role in 4-nitroanisole and 7-ethoxycoumarin metabolism in seven human liver samples. The addition of both MAbs to CYP2A6 and 2E1 to the microsome samples defined combinatorially the relative role of CYP2A6 and 2E1 in the metabolism of 4-nitroanisole and 7-ethoxycoumarin.
Electrophysiological determinants of atrial fibrillation in sinus node dysfunction despite atrial pacing (2000)

Prolonged atrial refractoriness, lesser degrees of conduction disturbance and a lower rate of atrial fibrillation induction seem to be predictive of stable sinus rhythm. In contrast, patients with persistence of atrial fibrillation despite pacing have a more abnormal and inhomogeneous atrial substrate, as well as a higher rate of atrial fibrillation induction. Prolonged P wave, shortened refractoriness, or remarkably abnormal conduction disturbances in the presence of prolonged refractoriness limit the effectiveness of standard atrial pacing in atrial fibrillation prevention. Identification of predictive criteria of failure of single-site atrial pacing may be used to consider dual-site atrial pacing in such patients with sinus node dysfunction.
RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2 (1997)

Steroids, thyroid hormones, vitamin D3, and retinoids are lipophilic small molecules that regulate diverse biological effects such as cell differentiation, development, and homeostasis. The actions of these hormones are mediated by steroid/nuclear receptors which function as ligand-dependent transcriptional regulators. Transcriptional activation by ligand-bound receptors is a complex process requiring dissociation and recruitment of several additional cofactors. We report here the cloning and characterization of receptor-associated coactivator 3 (RAC3), a human transcriptional coactivator for steroid/nuclear receptors. RAC3 interacts with several liganded receptors through a mechanism which requires their respective ligand-dependent activation domains. RAC3 can activate transcription when tethered to a heterologous DNA-binding domain. Overexpression of RAC3 enhances the ligand-dependent transcriptional activation by the receptors in mammalian cells. Sequence analysis reveals that RAC3 is related to steroid receptor coactivator 1 (SRC-1) and transcriptional intermediate factor 2 (TIF2), two of the most potent coactivators for steroid/nuclear receptors. Thus, RAC3 is a member of a growing coactivator network that should be useful as a tool for understanding hormone action and as a target for developing new therapeutic agents that can block hormone-dependent neoplasia.
Foundations of World Wide Web programming with HTML & CGI (1995)

Aimed toward the working programmer, this guide provides readers with everything they need to know to become experts at using the Hypertext Markup Language (HTML) to post on the Web. Liberally illustrated and detailed examples provide complete background and hands-on information to let programmers of any level design, install, and operate customized Web-specific CGI programs. CD contains ready-to-run programs and code fragments.
Slow Gastric Emptying in Type I Diabetes: Relation to Autonomic and Peripheral Neuropathy, Blood Glucose, and Glycemic Control (1997)

Slow gastric emptying in patients with type I diabetes seems related to the degree of autonomic neuropathy but not to peripheral neuropathy, actual blood glucose, and glycemic control.
SVD analysis of Array transmission and reception and its use for bootstrapping calibration (2016)

Data sets from calibration scans are reconstructed robustly and with optimal signal-to-noise ratio. The found array signal gain is furthermore a direct performance measure for array transmitter and receiver combinations. The concomitantly obtained image was shown to have maximum coverage of the subject. Magn Reson Med 76:1730-1740, 2016. © 2016 International Society for Magnetic Resonance in Medicine.
Model-less pose tracking (2007)

Acquiring 3-D motion of a camera from image sequences is one of the key components in a wide range of applications such as human computer interaction. Given the 3-D structure, the problem of camera motion recovery can he solved using the model-based approaches, which are well-known and have good performance under a controlled environment. If prior information on the scene is not available, traditional Structure from Motion (SFM) algorithms, which simultaneously estimate the scene structure and pose information, are required. The research presented in this thesis belongs to a different category: Motion from Motion (MFM), in which the main concern is the camera position and orientation. To be more precise, MFM algorithms have the capability of estimating 3-D camera motion directly from 2-D image motion without the explicit reconstruction of the scene structure, even though the 3-D model structure is not known in prior. As keeping track of the structural information is no longer required, putting these types of algorithms into real applications is relatively easy and convenient. 
The objective of this thesis is to develop a high-speed recursive approach that tackles the MFM problem. On the way to the final goal, a series of methods, each having its own strengths and characteristics, have been studied. (1) The first algorithm computes the camera pose from a monocular image sequence. The trifocal tensor is incorporated into the Extended Kalman Filter (EKF) formulation. The step of computing the 3-D models can thus be eliminated. (2) The proposed approach is then extended to the recovery of motion from a stereo image sequence. By applying the trifocal tensor to a stereo vision framework, the trifocal constraint becomes more robust and is not likely to be degenerate. In addition, the twist motion model is adopted to parameterize the 3-D motion. It does not suffer from singularities as Euler angles, and is minimal as opposed to quaternion and the direct use of rotation matrix. (3) The third method introduces the Interacting Multiple Model Probabilistic Data Association Filter (IMMPDAF) to the MFM problem. The Interacting Multiple Model (IMM) technique allows the existence of more than one dynamic system and in return leads to improved accuracy and stability even under abrupt motion changes. The Probabilistic Data Association (PDA) framework makes the automatic selection of measurement sets possible, resulting in enhanced robustness to occlusions and moving objects. As the PDA associates stereo correspondences probabilistically, the explicit establishment of stereo matches is not necessary except during initialization, and the point features present in the outer region of the stereo images can be utilized. 
It is demonstrated in the experiments that the proposed algorithms are efficient, stable and accurate compared to several existing approaches. Furthermore, they have been put into applications such as mixed reality, virtual reality, robotics and super-resolution to show their performance in real situations.
Manipulation of Lyophilization-Induced Phase Separation: Implications For Pharmaceutical Proteins (1997)

Lyophilization, or freeze-drying, of pharmaceutical proteins is often the only processing method that provides requisite long-term product stability. Freezing and drying, however, can cause acute damage to proteins. To alleviate damage, formulations frequently include protein stabilizers (often polymers and/or sugars), as well as buffering salts and "inert" bulking agents. While great efforts are placed on developing a formulation and suitable lyophilization cycle, incompatibilities among components through freezing and drying have been almost completely ignored. We demonstrate that solutions of poly(ethylene glycol) (PEG) and dextran, initially below critical concentrations for phase separation, do indeed experience a liquid-liquid phase separation induced by freeze concentration during the lyophilization cycle. The separation is shown to evolve with annealing at -7 degrees C and can be effectively inhibited simply by replacing NaCl with KCl in the formulation buffer. In addition, we show that phase separation causes unfolding of a model protein, recombinant hemoglobin, when freeze-dried in the PEG/dextran system. When the phase separation is averted by switching to KCl, the protein structural damage is also avoided. Measurements of pH in the frozen solutions show that the structural damage is not a result of pH changes. We suggest that KCl forms a glass with rapid cooling which kinetically prevents the phase separation and thus the protein structural damage.
A comparison of the lidocaine patch 5% vs naproxen 500 mg twice daily for the relief of pain associated with carpal tunnel syndrome: a 6-week, randomized, parallel-group study. (2006)

This study demonstrates that the lidocaine patch 5% is effective in significantly relieving the pain associated with CTS and is well tolerated. The patch may offer patients an effective, nonsystemic, noninvasive treatment for the management of their symptoms. Further controlled studies are warranted.
WENC: HTTPS Encrypted Traffic Classification Using Weighted Ensemble Learning and Markov Chain (2017)

SSL/TLS protocol is widely used for secure web applications (i.e., HTTPS). Classifying encrypted SSL/TLS based applications is an important but challenging task for network management. Traditional traffic classification methods are incapable of accomplishing this task. Several recently proposed approaches that focused on discriminating defining fingerprints among various SSL/TLS applications have also shown various limitations. In this paper, we design a Weighted ENsemble Classifier (WENC) to tackle these limitations. WENC studies the characteristics of various sub-flows during the HTTPS handshake process and the following data transmission period. To increase the fingerprint recognizability, we propose to establish a second-order Markov chain model with a fingerprint variable jointly considering the packet length and the message type during the process of HTTPS handshake. Furthermore, the series of the packet lengths of application data is modeled as HMM with optimal emission probability. Finally, a weighted ensemble strategy is devised to accommodate the advantages of several approaches as a unified one. Experimental results show that the classification accuracy of the proposed method reaches 90%, with an 11% improvement on average comparing to the state-of-the-art methods.
Monoclonal antibody BW835 defines a site-specific Thomsen-Friedenreich disaccharide linked to threonine within the VTSA motif of MUC1 tandem repeats. (1995)

mAb BW835 (IgG1) has been generated to breast cancer cell lines by alternating injections of MCF-7 or SW-613 cells and has been demonstrated to be of value in the serodiagnosis of mammary carcinoma. BW835 defines a carbohydrate epitope on integrated or secreted MUC1 glycoforms from carcinoma cells and human milk. To identify BW835-reactive glycopeptides on MUC1, proteolytic fragments of the mucin obtained by digestion with the Gly-C-specific endopeptidase IV from papaya corresponding to low molecular mass fragments (< 10 kilodaltons) of the tandem repeat domain were screened. A glycosylated fragment (glycopeptide 17) containing the mAb HMFG-2-defined epitope was highly reactive to BW835 antibody, while nonglycosylated tandem repeat peptide TAP25 or its in vitro-glycosylated N-acetylgalactosamine (GalNAc) derivatives were unreactive. Glycopeptide 17 bound to peanut agglutinin and to a Thomsen-Friedenreich antigen (TF alpha)-specific mAb (A78-G/A7). Binding of BW835 to glycopeptide 17 or to MUC1 was competitively inhibited by peanut agglutinin and by the synthetic glycopeptides TF alpha Ser or TF alpha Thr but not by their beta-anomers. Evidence for site specificity of binding by BW835 to glycopeptide 17 was revealed by demonstrating nonreactivity of the antibody to other TF alpha-expressing glycoproteins with peptide moieties lacking MUC1-specific motifs at putative glycosylation sites. The epitope of BW835 was localized to threonine within the VTSA-peptide motif by site-specific enzymatic beta-galactosylation of the synthetic tandem repeat peptide TAP25-GalNAc1 TAPPAHGVT(-O-alpha GalNAc)SAPDTRPAPGSTAPPA. This is the first report on a TF alpha-specific mAb that shows a strict peptide sequence dependency of binding.
Modeling and estimation of FPN components in CMOS image sensors (1998)

Fixed pattern noise (FPN) for a CCD sensor is modeled as a sample of a spatial white noise process. This model is, however, not adequate for characterizing FPN in CMOS sensors, since the redout circuitry of CMOS sensors and CCDs are very different. The paper presents a model for CMOS FPN as the sum of two components: a column and a pixel component. Each component is modeled by a first order isotropic autoregressive random process, and each component. Each component is modeled by a first order isotropic autoregressive random process, and each component is assumed to be uncorrelated with the other. The parameters of the processes characterize each component of the FPN and the correlations between neighboring pixels and neighboring columns for a batch of sensor. We show how to estimate the model parameters from a set of measurements, and report estimates for 64 X 64 passive pixel sensor (PPS) and active pixel sensor (APS) test structures implemented in a 0.35 micron CMOS process. High spatial correlations between pixel components were measured for the PPS structures, and between the column components in both PPS and APS. The APS pixel components were uncorrelated.
Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs (2017)

Lotilaner at a minimum dose rate of 20 mg/kg began to kill ticks on dogs within 4 h of treatment and efficacy was 100% within 8 h. Lotilaner sustained a rapid kill of newly infesting I. ricinus through 35 days. By quickly killing ticks that infest dogs, lotilaner has potential to help limit the transmission of tick-borne pathogens.
High frequency ultrasound characterization of the blood clotting process: intra- and inter-individual variations (2006)

In a previous work, we showed the potential of an in vitro high frequency ultrasound device to describe the blood clotting process. The parameters were simultaneously estimated in double transmission (DT) and in backscattering (BSC) modes. We showed that BSC-mode and DT-mode parameters were complementary to give a fine description of blood coagulation process in terms of mechanical properties (blood solidification) and spatial distribution of blood components (formation RBC aggregates). In the present paper, our purpose was first to refine our results on the phenomenon of the red blood cell (RBC) aggregation, and to estimate inter-individual and intra-individual variations of these parameters describing the blood clotting process according to several protocols. By comparing intra- and inter-individual variations, discriminating potential of the acoustical parameters was assessed.
Self-assembled π-stacks of functional dyes in solution: structural and thermodynamic features (2008)

This critical review provides an overview on the formation of pi-stacks of functional dyes in solution, aiming to acquaint young researchers with this topical research field and to stimulate further advance in supramolecular dye chemistry. Different mathematical models that have been proposed and applied for the description of aggregation equilibria of pi-systems in solution are discussed. The factors that have significant impact on the structural features of aggregates and the thermodynamics of pi-pi stacking such as electrostatic interactions, size and geometry of the dye molecules are covered in this review. A comparison of the binding strength is made for different classes of functional pi-conjugated systems, from simple benzene to more extended polycyclic hydrocarbon molecules, including triphenylenes and hexabenzocoronenes, heteroaromatic porphyrins and phthalocyanines, quadrupolar naphthalene and perylene bisimides, dipolar or even zwitterionic merocyanines and squaraines, and some macrocyclic dyes. Solvent effects on binding constants are analysed by linear free energy relationships with various solvent polarity scales (98 references with multiple entries).