gebhart/patrepeval huggingface dataset:
Algorithms for Bayesian belief-network precomputation. (1991)

Bayesian belief networks provide an intuitive and concise means of representing probabilistic relationships among the variables in expert systems. A major drawback to this methodology is its computational complexity. We present an introduction to belief networks, and describe methods for precomputing, or caching, part of a belief network based on metrics of probability and expected utility. These algorithms are examples of a general method for decreasing expected running time for probabilistic inference. We first present the necessary background, and then present algorithms for producing caches based on metrics of expected probability and expected utility. We show how these algorithms can be applied to a moderately complex belief network, and present directions for future research.
Achieving and Maintaining Insulin Independence in Human Islet Transplant Recipients (2005)

For islet transplants to complete the transition from clinical research to clinical care restoration of insulin independence must be achieved--as with pancreas transplants--with a single donor. To achieve this critical milestone more consistently it will be imperative to pursue the following complementary strategies simultaneously: 1) enhancing the metabolic potency, inflammatory resilience, and immune stealth of isolated islets; 2) inhibiting the thrombotic and inflammatory responses to transplanted islets; and 3) achieving immune protection with strategies lacking diabetogenic side effects. Maintaining insulin independence will be a different challenge requiring us to clarify whether failure of initially successful islet allografts in type 1 diabetes is related: to 1) failure of immunosuppressive regimens to control alloimmunity and autoimmunity; 2) failure of islet regeneration in the presence of currently applied immunosuppressive regimens; and/or 3) failure of islet neogenesis in the absence of an adequate mass and viability of co-transplanted/engrafted islet precursor cells.
Closed Loop Control of a Gravity-assisted Underactuated Snake Robot with Application to Aircraft Wing-Box Assembly (2008)

Stable, nonlinear closed-loop control of a gravityassisted underactuated robot arm with 2nd order non-holonomic constraints is presented in this paper. The joints of the hyper articulated arm have no dedicated actuators, but are activated with gravity. By tilting the base link appropriately, the gravitational torque drives the unactuated links to a desired angular position. With simple locking mechanisms, the hyper articulated arm can change its configuration using only one actuator at the base. This underactuated arm design was motivated by the need for a compact snake-like robot that can go into aircraft wings and perform assembly operations using heavy end-effecters. The dynamics of the unactuated links are essentially 2nd order nonholonomic constraints, for which there are no general methods for designing closed loop control. We propose an algorithm for positioning the links of an n-link robot arm inside an aircraft wing-box. This is accomplished by sequentially applying a closed loop point-to-point control scheme to the unactuated links. We synthesize a Lyapunov function to prove the convergence of this control scheme. The Lyapunov function also provides us with lower bounds on the domain of convergence of the control law. The control algorithm is implemented on a prototype 3-link system. Finally, we provide some experimental results to demonstrate the efficacy of the control scheme.
Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1 (1992)

Follicular lymphomas recapitulate the architecture of germinal centers (GCs) of normal secondary lymphoid follicles. Using an in vitro binding assay, it has recently been demonstrated that the normal B lymphocytes bind to GCs. This interaction is mediated by a receptor-ligand pair consisting of the beta 1 integrin very late antigen 4 (VLA-4) on the B cell, and the vascular cell adhesion molecule-1 (VCAM-1) expressed on follicular dendritic cells (FDC). Considering the similarities between follicular lymphomas and normal GCs, the adhesive interaction of follicular non-Hodgkin's lymphoma (NHL) cells and GCs was examined. Cells isolated from 16 of 24 cases of follicular NHL bound to normal GCs. Neoplastic follicles could similarly support the binding of follicular NHL cells. This adhesion was inhibited by monoclonal antibodies (MoAbs) directed against VLA-4 and VCAM-1. This supports the hypothesis that the neoplastic follicles used the identical adhesive interactions responsible, at least in part, for the localization of normal B cells to GCs. Adhesion receptors have an important role in the regulation of normal lymphoid cell proliferation, differentiation, and localization. Therefore, an understanding of the adhesive interaction of follicular NHL cells with GCs may provide insight into the clinical and biologic behavior of these diseases.
Discovery and Design of Retinoic Acid Receptor and Retinoid X Receptor Class- and Subtype-Selective Synthetic Analogs of All-trans-retinoic Acid and 9-cis-Retinoic Acid (2002)

This review presents a historical overview of the discoveries of retinoic acid receptor (RAR) and retinoid X receptor (RXR) class- and subtype-selective synthetic retinoids. These synthetic retinoids are conformationally restricted by having aromatic rings in place of the tetraene bond systems of all-trans- and 9-cis-retinoic acids. Events leading to the design and synthesis of such retinoid transcriptional agonists as RAR subtype beta,gamma-selective 6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-2-naph-thalenecarboxylic acid (TTNN), the RARgamma-selective Z-oxime of 6-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylcarbonyl)-2-naphthalenecarboxylic acid (SR11254), RAR-selective 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl) benzoic acid (TTAB), RXR-selective 4-[1-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-cyclopropyl] benzoic acid (SR11246), RXR-selective 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-2-methylpropenyl]benzoic acid (SR11345), and RARgamma-selective retinoid transcriptional antagonist 2-(6-carboxy-2-naphthalenyl)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolane (SR11253) are described.
Transcriptional Map of the Measles Virus Genome (1986)

We have constructed a recombinant DNA library of the measles virus genome and identified gene-specific clones containing sequences coding for portions of each of the six viral structural proteins, as well as clones coding for intercistronic sequences. By Northern blotting, we could order the clones according to the pattern of individual gene-specific and readthrough mRNAs. Clones corresponding to the N, P/C and M genes were identified by correlation of the mRNAs with their in vitro translation products; clones corresponding to the H, F and L genes were identified by indirect evidence. The results indicated that the gene order in measles virus is that of a typical paramyxovirus (3'-N,P/C,M,F,H,L-5'), but that the M and F transcripts each contain 1.5 times the coding capacity needed for synthesis of these proteins in vivo.
Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I (1995)

Photoreactive analogues of prenyl diphosphates have been useful in studying prenyltransferases. The effectiveness of analogues with different chain lengths as probes of recombinant human protein prenyltransferases is established here. A putative geranylgeranyl diphosphate analogue, 2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate (DATFP-FPP), was the best inhibitor of both protein farnesyltransferase (PFT) and protein geranylgeranyltransferase-I (PFFT-I). Shorter photoreactive isprenyl diphosphate analogues with geranyl and dimethylallyl moieties and the DATFP-derivative of farnesyl monophosphate were much poorer inhibitors. DATFP-FPP was a competitive inhibitor of both PFT and PGGT-I with Ki values of 100 and 18 nM, respectively. [32P]DATFP-FPP specifically photoradiolabelled the beta-subunits of both PFT and PGGT-I. Photoradiolabelling of PGGT-I was inhibited more effectively by geranylgeranyl diphosphate than farnesyl diphosphate, whereas photoradiolabelling of PFT was inhibited better by farnesyl diphosphate than geranylgeranyl diphosphate. These results lead to the conclusions that DATFP-FPP is an effective probe of the prenyl diphosphate binding domains of PFT and PGGT-I. Furthermore, the beta-subunits of protein prenyltransferases must contribute significantly to the recognition and binding of the isoprenoid substrate.
Comparative Study of Cochlear Damage With Three Perimodiolar Electrode Designs (2003)

Insertion trauma caused by periomodiolar electrodes occurs to an acceptable degree. Refinement of electrodes based on mechanisms of trauma may be able to further reduce damage.
Rational Design of Sequestering Agents for Plutonium and Other Actinides (2003)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRational Design of Sequestering Agents for Plutonium and Other ActinidesAnne E. V. Gorden, Jide Xu, Kenneth N. Raymond, and Patricia DurbinView Author Information Department of Chemistry, University of California, Berkeley, California 94720 Chemical Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 Cite this: Chem. Rev. 2003, 103, 11, 4207–4282Publication Date (Web):October 28, 2003Publication History Received23 December 2002Published online28 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/cr990114xhttps://doi.org/10.1021/cr990114xresearch-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views4394Altmetric-Citations487LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Actinides,Anatomy,Ligands,Organic polymers,Rodent models Get e-Alerts
A class of min-cut placement algorithms (1977)

In this paper we present a class of min-cut placement algorithms for solving some assignment problems related to the physical implementation of electrical circuits. We discuss the need for abandoning classical objective functions based upon distance, and introduce new objective functions based upon cut. The number of signals cut by a line c is a lower bound on the number of routing tracks which must cross c in routing the circuit. Three specific objective functions are introduced and the relationship between one of these and a classical distance measure based upon half-perimeter is presented. Two min-cut placement algorithms are presented. They are referred to as Ouadrature and Slice/Bisection. The concepts of a block and cut line are introduced. These two entities are the major constructs in developing any new min-cut placement algorithm.Most of the concepts presented have been implemented, and some experimental results are given.
Recombinant interferon-alpha 2a and vinblastine in advanced renal cell cancer: a clinical phase I-II study. (1990)

Twenty patients with metastatic renal cell cancer were treated with a combination of recombinant interferon-alpha 2a (Roferon-A), 18 MU intramuscularly three times weekly and vinblastine 0.1 mg/kg intravenously once every 3 weeks. Three patients experienced a complete response (CR) (15%) and three a partial response (PR) (15%). The response duration was 3, 13, and 15 months in the CR group, and PRs lasted 11, 13, and 14 months. Constitutional symptoms like fever, anorexia, and fatigue were the most common side effects. One patient had reversible hepatitis, which was probably unrelated to antineoplastic therapy. Dose modifications had to be made in seven patients due to leukopenia or thrombocytopenia. No very serious side effects were noticed. In view of what has been reported previously, the overall response rate (30%) of this regimen is good and tolerance of the treatment is acceptable.
Guanylyl Cyclase C as a Biomarker for Targeted Imaging and Therapy of Metastatic Colorectal Cancer (2009)

The guanylyl cyclase C (GCC) receptor posseses several well-established properties ideal for use as a biomarker in gastrointestinal malignancies. The GCC receptor is constitutively expressed in the apical membranes of the intestine and its expression is universally preserved in primary colorectal tumors and their metastases. Moreover, receptor binding is retained by GCC's cognate ligand, the bacterial enterotoxin ST, even after conjugation to functional moieties. Selective tumor, but not gastrointestinal, uptake of ST in mice bearing GCC-expressing colon cancer xenografts demonstrates the potential of exploiting ST-GCC interaction for diagnostic imaging and targeted therapy of metastatic colorectal cancer. We expect this specific targeting provided by ST-GCC interaction to improve diagnosis, staging and management of colorectal cancer metastases, and ultimately prolong patient survival in this disease.
Hypertension with or without hemodilution after cardiac arrest in dogs. (1990)

We studied blood flow-promoting therapies after cardiac arrest in 18 dogs. Our model consisted of ventricular fibrillation (no blood flow) lasting 12.5 minutes, controlled reperfusion with cardiopulmonary bypass and defibrillation within 5 minutes, controlled intermittent positive-pressure ventilation to 20 hours, and intensive care to 96 hours. Group I (control, n = 6) dogs were reperfused under conditions of normotension (mean arterial blood pressure 100 mm Hg) and normal hematocrit (greater than or equal to 35%). Group II (n = 6) and III (n = 6) dogs were treated with norepinephrine at the beginning of reperfusion to induce hypertension for 4 hours. In addition, group III dogs received hypervolemic hemodilution to a hematocrit of 20% using dextran 40. There were no differences in the time to recovery of electroencephalographic activity among groups. All six group I dogs remained severely disabled; in groups II and III combined, six of the 12 dogs achieved good outcome (p less than 0.01). Some regional histopathologic damage scores at 96 hours were better in groups II and/or III than in group I (neocortex: p less than 0.05 group II different from group I; hippocampus: p less than 0.01 both groups II and III different from group I). Total histopathologic damage scores were similar among the groups. A hypertensive bout with a peak mean arterial blood pressure of greater than or equal to 200 mm Hg beginning 1-5 minutes after the start of reperfusion was correlated with good outcome (p less than 0.01). Our results support the use of an initial bout of severe hypertension, but not the use of delayed hemodilution.
Design of Planar Rectangular Microelectronic Inductors (1974)

Negative mutual inductance results from coupling between two conductors having current vectors in opposite directions. As a quantity in electronic circuits, negative mutual inductance is usually so much smaller in magnitude than overall inductance that it can be neglected with little effect. In the microelectronic world, however, its neglect can result in inductance values as much as 30 percent too high. This paper derives inductance equations for planar thin- or thick-film coils, comparing equations that include negative mutual inductance with those that do not. It describes a computer program developed for calculating inductances for both square and rectangular geometries, the variables considered being track width, space between tracks, and number of turns. Graphic results are presented for up to 16 turns over an inductance range of 3 nanohenries to 10 microhenries. Although details of fabrication are not included, the effects of film thickness and frequency on the mutual-inductance parameter are discussed.
A Missense Cystic Fibrosis Transmembrane Conductance Regulator Mutation With Variable Phenotype (1997)

The G85E mutation shows variable clinical presentation in all clinical parameters. This variability could be seen among patients carrying on the other chromosome the same CFTR mutation, and also among siblings. This variability is not associated with the level of exon 9 skipping. Thus, the G85E mutation cannot be classified either as a severe or as a mild mutation.
Structured Porous Materials via Colloidal Crystal Templating: From Inorganic Oxides to Metals (2000)

The formation of nanostructured materials by using colloidal crystals as templates is a relatively new but rapidly growing area of materials science. Colloid crystalline templates are three-dimensional close-packed crystals of submicrometer spheres, whose long-ranged ordered structure is replicated in a solid matrix, to yield materials with ordered pores. These materials hold promise for use as photonic crystals, advanced catalysts, and in a variety of other applications. Here we review the wide range of materials that have been made following the original synthesis of structured porous silica. This method has been recently modified to produce porous metals.
<title>FaceIt: face recognition from static and live video for law enforcement</title> (1997)

Recent advances in image and pattern recognition technology- -especially face recognition--are leading to the development of a new generation of information systems of great value to the law enforcement community. With these systems it is now possible to pool and manage vast amounts of biometric intelligence such as face and finger print records and conduct computerized searches on them. We review one of the enabling technologies underlying these systems: the FaceIt face recognition engine; and discuss three applications that illustrate its benefits as a problem-solving technology and an efficient and cost effective investigative tool.
Two cases of severe neonatal hypertrophic cardiomyopathy caused by compound heterozygous mutations in the MYBPC3 gene (2006)

The findings indicate the need for mutation analysis of genes encoding sarcomeric proteins in childhood HCM and the possibility of compound heterozygosity.
EpCAM: A New Therapeutic Target for an Old Cancer Antigen (2003)

The use of monoclonal antibodies as adjuvants to cancer chemotherapy has drawn considerable interest in recent years, due to the success of several novel agents against a broad range of targets. One such target is EpCAM (aka GA733-2, KSA, 17-1A antigen), a human cell surface glycoprotein expressed on some normal and most neoplastic epithelial cells. It is now widely recognized as having an important role in tumor biology, especially in colorectal cancer, and since its original discovery in the early 1980s, the known mechanism by which it functions has steadily evolved. Initial studies of monoclonal antibodies directed against EpCAM demonstrated the presence of anti-idiotype networks involving both B and T cells, antibody-dependent cell cytotoxicity, and complement mediated cell death as mechanisms of tumor growth inhibition. Recently, a novel receptor for EpCAM has been described that is a member of the inhibitory group of immunoglobulin-like receptors and is present on lymphocytes, monocytes, dendritic cells, and NK cells. Neoplastic cells that interact with this receptor, named LAIR-1, may enact an immunologic escape, and thus confer a selective advantage for their growth and spread. This novel mechanism of action may add to our current understanding of how monoclonal antibodies targeted against EpCAM inhibit tumor growth. Passive vaccination with this antibody may induce a tertiary anti-idiotypic network which correlates with clinical outcome, but the mechanism behind this outcome in select patients with minimal residual disease may additionally involve a novel blockade of tumor specific immunosuppression. This review will focus on the initial discoveries of EpCAM's cellular adhesion properties, its role in normal and neoplastic cell function, its distribution and presumed mechanism of action, and clinical studies of EpCAM as a therapeutic target. Clinical trials of edrecolomab, one such monoclonal antibody, in patients with colon cancer will be reviewed and updated. While phase III trials of edrecolomab have not demonstrated improved efficacy as adjuvant therapy for stage III colon cancer, newer agents with improved affinity, less chimerism, and improved delivery may still demonstrate benefit.
IN VIVO ANTIGENIC STUDIES OF PARAINFLUENZA VIRUSES1 (1963)

Journal Article IN VIVO ANTIGENIC STUDIES OF PARAINFLUENZA VIRUSES Get access M. KATHERINE COOK, M. KATHERINE COOK Department of Health, Education, and Welfare, Public Health Service, National Institutes of Allergy and Infectious Diseases, Laboratory of Infectious DiseasesBethesda, Maryland. Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT M. CHANOCK ROBERT M. CHANOCK Department of Health, Education, and Welfare, Public Health Service, National Institutes of Allergy and Infectious Diseases, Laboratory of Infectious DiseasesBethesda, Maryland. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 77, Issue 2, March 1963, Pages 150–159, https://doi.org/10.1093/oxfordjournals.aje.a120304 Published: 01 March 1963 Article history Received: 17 October 1962 Published: 01 March 1963
Posterior Tibial Nerve Stimulation vs Parasacral Transcutaneous Neuromodulation for Overactive Bladder in Children (2013)

We found that parasacral transcutaneous electrical nerve stimulation is more effective in resolving overactive bladder symptoms, which matches parental perception. However, there were no statistically significant differences in the evaluation by dysfunctional voiding symptom score, or in complete resolution of urgency or diurnal incontinence.