gebhart/patrepeval huggingface dataset:
Synthesis, oxidation, and electronic spectra of four dithienothiophenes (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, oxidation, and electronic spectra of four dithienothiophenesMatthijs J. Janssen and Feike De JongCite this: J. Org. Chem. 1971, 36, 12, 1645–1648Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/jo00811a016https://doi.org/10.1021/jo00811a016research-articleACS PublicationsRequest reuse permissionsArticle Views1171Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems (2014)

Controlling the composition of microbial populations is a critical aspect in medicine, biotechnology, and environmental cycles. While different antimicrobial strategies, such as antibiotics, antimicrobial peptides, and lytic bacteriophages, offer partial solutions, what remains elusive is a generalized and programmable strategy that can distinguish between even closely related microorganisms and that allows for fine control over the composition of a microbial population. This study demonstrates that RNA-directed immune systems in bacteria and archaea called CRISPR-Cas systems can provide such a strategy. These systems can be employed to selectively and quantitatively remove individual bacterial strains based purely on sequence information, creating opportunities in the treatment of multidrug-resistant infections, the control of industrial fermentations, and the study of microbial consortia.
Condor-a hunter of idle workstations (2003)

The design, implementation, and performance of the Condor scheduling system, which operates in a workstation environment, are presented. The system aims to maximize the utilization of workstations with as little interference as possible between the jobs it schedules and the activities of the people who own workstations. It identifies idle workstations and schedules background jobs on them. When the owner of a workstation resumes activity at a station, Condor checkpoints the remote job running on the station and transfers it to another workstation. The system guarantees that the job will eventually complete, and that very little, if any, work will be performed more than once. A performance profile of the system is presented that is based on data accumulated from 23 stations during one month.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer (2015)

miR-144-5p functions as tumour suppressor in BC cells. CCNE1 and CCNE2 were directly regulated by miR-144-5p and might be good prognostic markers for survival of BC patients.
Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreaticβ-Cells (2012)

Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetal β-cell is unknown. We measured the impact of one week of chronic constant hyperglycemia (CHG, n = 6) versus pulsatile hyperglycemia (PHG, n = 5) versus controls (n = 7) on the percentage of the fetal pancreas staining for insulin (β-cell area), mitotic and apoptotic indices and size of fetal β-cells, and fetal insulin secretion in sheep. Baseline insulin concentrations were higher in CHG fetuses (P < 0.05) compared to controls and PHG. GSIS was lower in the CHG group (P < 0.005) compared to controls and PHG. PHG β-cell area was increased 50% (P < 0.05) compared to controls and CHG. CHG β-cell apoptosis was increased over 400% (P < 0.05) compared to controls and PHG. These results indicate that late gestation constant maternal hyperglycemia leads to significant β-cell toxicity (increased apoptosis and decreased GSIS). Furthermore, pulsatile maternal hyperglycemia increases pancreatic β-cell area but did not increase GSIS, indicating decreased β-cell responsiveness. These findings demonstrate differential effects that the pattern of maternal hyperglycemia has on fetal pancreatic β-cell development, which might contribute to later life limitation in insulin secretion.
Synthesis and Optical Properties of Simple Amine-Containing Conjugated Polymers (2005)

Conjugated polymers (CPs) containing amino groups have been synthesized, and their optical properties in both solution and thin film have been studied. New monomers required for the synthesis of these polymers have been readily prepared via efficient synthetic routes. These monomers have been successfully polymerized with a variety of comonomers. The spectral positions of the absorption and emission spectra correlate with the degree of electron density on the polymer chain. Polymers containing N-alkylcarbazole units display similar optical properties in solution to most CPs. Polymers with dialkylamino groups, however, display very different optical properties, including broadened absorbance and emission spectra, larger Stokes shifts, and longer excited state lifetimes. These results are consistent with a significant difference between the molecular geometries of the absorbing and emitting states. The solid state emission of most of the polymers is sufficient to warrant them for consideration as fluorescent sensing materials.
Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk) (2001)

Glycated haemoglobin concentration seems to explain most of the excess mortality risk of diabetes in men and to be a continuous risk factor through the whole population distribution. Preventive efforts need to consider not just those with established diabetes but whether it is possible to reduce the population distribution of HbA(1c) through behavioural means.
CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-γ and phosphatidylinositol 3-kinase (1996)

Ligation of CD38 inhibits proliferation and induces apoptosis of human immature B cells, but the molecular mechanisms underlying this function are unknown. We found that CD38 dimerization with the specific mAbs T16 and IB4 induces rapid and transient tyrosine phosphorylation of several intracellular proteins in the immature B cell lines RS4;11, REH, 380, Nalm6, and OP-1. This effect could be markedly reduced by incubating cells with the tyrosine kinase inhibitors genistein, staurosporine, and herbimycin A. CD38 dimerization induced tyrosine phosphorylation of the protein kinase syk and increased syk kinase activity. CD38 dimerization also induced tyrosine phosphorylation of phospholipase C-gamma and of the p85 subunit of phosphatidylinositol 3-kinase (PI 3-K). The latter was accompanied by a distinct increase in PI 3-kinase activity in the immunoprecipitates obtained with an anti-phosphotyrosine Ab. In contrast to the signaling triggered by surface Ig engagement in B lymphocytes, CD38 ligation did not appear to induce tyrosine phosphorylation of the src-like protein tyrosine kinases lyn, fyn, and btk, or of vav- and ras-GTPase-activating protein, nor did it induce detectable changes in cytosolic CA2+ concentrations. CD38 signaling also differed from cytokine-induced signaling in that it did not cause tyrosine phosphorylation of Jak1 and Jak2. Finally, CD38 ligation did not inhibit IL-3-induced tyrosine phosphorylation of Jak2. These results identify CD38 as a cell surface receptor with signal transduction properties activated by dimerization. Induction of signal transduction by CD38 ligation implies the existence of a yet unidentified natural ligand of CD38.
UI Portals: Sharing Arbitrary Regions of User Interfaces on Traditional and Multi-user Interactive Devices (2012)

This paper introduces UI Portals, a novel approach to help users share their off-the-shelf applications' user interfaces on traditional and multi-user interactive devices among various platforms. Users can choose an application window or select parts of the window to share. In addition to the traditional single-user mouse-and-keyboard interaction, we provide support for simultaneous interactions on large multi-user interactive surfaces, like tabletops and multi-touch vertical surfaces. We describe the concepts and implementation mechanisms of this approach. Furthermore, we implement UI Portals Toolsets (UIPT), a prototype that demonstrates sharing arbitrary regions of user interfaces among multiple platforms without any change to the application source code. In UIPT, we design a windowing tool dedicated to large multi-user interactive surfaces to fully leverage the benefit of simultaneous interaction. Two typical scenarios demonstrate the utility of UIPT and show how UIPT can help users work with their familiar software applications on different displays and platforms.
Mutational Analysis of Xanthomonas Harpin HpaG Identifies a Key Functional Region That Elicits the Hypersensitive Response in Nonhost Plants (2004)

HpaG is a type III-secreted elicitor protein of Xanthomonas axonopodis pv. glycines. We have determined the critical amino acid residues important for hypersensitive response (HR) elicitation by random and site-directed mutagenesis of HpaG and its homolog XopA. A plasmid clone carrying hpaG was mutagenized by site-directed mutagenesis, hydroxylamine mutagenesis, and error-prone PCR. A total of 52 mutants were obtained, including 51 single missense mutants and 1 double missense mutant. The HR elicitation activity was abolished in the two missense mutants [HpaG(L50P) and HpaG(L43P/L50P)]. Seven single missense mutants showed reduced activity, and the HR elicitation activity of the rest of the mutants was similar to that of wild-type HpaG. Mutational and deletion analyses narrowed the region essential for elicitor activity to the 23-amino-acid peptide (H2N-NQGISEKQLDQLLTQLIMALLQQ-COOH). A synthetic peptide of this sequence possessed HR elicitor activity at the same concentration as the HpaG protein. This region has 78 and 74% homology with 23- and 27-amino-acid regions of the HrpW harpin domains, respectively, from Pseudomonas and Erwinia spp. The secondary structure of the peptide is predicted to be an alpha-helix, as is the HrpW region that is homologous to HpaG. The predicted alpha-helix of HpaG is probably critical for the elicitation of the HR in tobacco plants. In addition, mutagenesis of a xopA gene yielded two gain-of-function mutants: XopA(F48L) and XopA(F48L/M52L). These results indicate that the 12 amino acid residues between L39 and L50 of HpaG have critical roles in HR elicitation in tobacco plants.
An alternate radial basis function neural network model (2002)

A new robust RBF neural network model is presented which, when compared with a conventional RBF neural network, has mathematically sound learning properties and better function approximation capabilities. The proposed RBF function uses log-sigmoid functions as the basis function which eliminate any risk of mathematical instabilities, as can be the case during the learning phase of Gaussian basis radial function networks. The performance of the proposed scheme is illustrated by simulation results of a nonlinear system identification problem. The results indicate that the proposed model performs well for nonlinear system identification problems.
Pfam: clans, web tools and services (2005)

Pfam is a database of protein families that currently contains 7973 entries (release 18.0). A recent development in Pfam has enabled the grouping of related families into clans. Pfam clans are described in detail, together with the new associated web pages. Improvements to the range of Pfam web tools and the first set of Pfam web services that allow programmatic access to the database and associated tools are also presented. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://pfam.cgb.ki.se/).
Pyrolytic Decarboxylation and Cracking of Stearic Acid (2008)

The primary objective of this work was to study the pyrolytic conversion of fatty acids to produce deoxygenated, liquid hydrocarbon products for use as renewable chemicals or fuels. Stearic acid (n-octadecanoic acid) was chosen as a model compound for the free fatty acids liberated through the hydrolysis of beef tallow. Batch pyrolysis of stearic acid was conducted over a range of temperatures and times, and the reaction products were extracted and identified through gas chromatography and mass spectrometry. Under mild conditions, n-heptadecane was the main product, with concurrent production of CO2, showing that decarboxylation was likely the first reaction to occur. Distinct series of n-alkanes and 1-alkenes developed and shifted to lower carbon numbers with increased temperature and time, consistent with hydrocarbon cracking reactions. Eventually, the series decomposed to aromatics, insoluble solids, and unidentified low-molecular-weight species. Semiquantitative analysis of the chromatographic data confirmed the predominance of n-heptadecane in the product mixture, the development and decomposition of the aliphatic species, the selectivity for n-alkanes over 1-alkenes, and the shift in product distribution toward lower carbon numbers. This work demonstrates the feasibility of producing liquid hydrocarbons through the pyrolysis of free fatty acids hydrolyzed from lipid feeds.
Molecular Imaging of Inflammation in Atherosclerosis With Targeted Ultrasound Detection of Vascular Cell Adhesion Molecule-1 (2007)

CEU molecular imaging of VCAM-1 is capable of rapidly quantifying vascular inflammatory changes that occur in different stages of atherosclerosis. This method may be potentially useful for early risk stratification according to inflammatory phenotype.
A robust framework for content-based retrieval by spatial similarity in image databases (1999)

A framework for retrieving images by spatial similarity (FRISS) in ima ge databases is presented. In this framework, a robust retrieval by spatial similarity (RSS) algorithm is defined as one that incorporates both directional and topological spatial constraints, retrieves similar images, and recognized images even after they undergo translation, scaling, rotation (both perfect and multiple), or any arbitrary combination of transformatioins. The FRISS framework is discussed and used as a base for comparing various existing RSS algorithms. Analysis shows that none of them satisfies all the FRISS specifications. An algorithm, SIM dtc , is then presented. SIM dtc introduces the concept of a rotation correction angle (RCA) to align objects in one image spatially closer to matching objects in another image for more accurate similarity assessment. Similarity between two images is a function of the number of common objects between them and the closeness of directional and topological spatial relationships between object pairs in both images. The SIM dtc retrieval is invariant under translation, scaling, and perfect rotation, and the algorithm is able to rank multiple rotation variants. The algorithm was tested using synthetic images and the TESSA image database. Analysis shows the robustness of the SIM dtc algorithm over current algorithms.
Morphologic Responses to a Murine Erythroblastosis Virus<xref ref-type="fn" rid="FN1">2</xref> (1967)

A recently described mouse erythroblastosis virus (MEV) was passed to newborn W/Fu rats. The rats developed generalized malignant lymphomas after 6-7 months. Two separate serial cell-free passage series were initiated. Rat lymphomas induced erythroblastosis in less than 20% of the rats that died within 4 weeks after inoculation. The surviving rats remained apparently healthy for months until they died from lymphomas. Inoculation of newborn C3Hf/Gs mice with the same Filtrates caused only lymphomas in 35-50% of the mice after 3-8 months. The lymphomas were morphologically indistinguishable from thymic lymphomas induced in mice and rats by Gross' leukemia virus. A different morphologic response was observed by serial passages of spleen filtrates or plasma from rats with erythroblastosis. All rats died within 4 weeks with erythroblastosis. In addition, multiple sarcomas and polyostotic osteolytic lesions were found in most rats of such erythroblastosis passages. The same rat erythroblastosis filtrates induced erythroblastosis and sarcomas but no osteolytic lesions in C3Hf/Gs mice. Erythroblastosis in rats was similar to the disease previously described in mice, except for a marked normoblastosis and cerebral hemorrhages which did not occur in erythroblastotic mice. The sarcomas arose in multiple sites and were histologically undifferentiated. The osteolytic lesions were likewise multicentric in origin, affecting particularly the vertebrae and long bones. Their exact nature could not be determined.
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation (2015)

Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that GKT137831, a dual NOX1/4 inhibitor, attenuated liver fibrosis in mice as well as pro-fibrotic genes in hepatic stellate cells (HSCs) as well as hepatocyte apoptosis. The effect of NOX1 and NOX4 deficiency in liver fibrosis is unclear, and has never been directly compared. HSCs are the primary myofibroblasts in the pathogenesis of liver fibrosis. Therefore, we aimed to determine the role of NOX1 and NOX4 in liver fibrosis, and investigated whether NOX1 and NOX4 signaling mediates liver fibrosis by regulating HSC activation. Mice were treated with carbon tetrachloride (CCl4) to induce liver fibrosis. Deficiency of either NOX1 or NOX4 attenuates liver injury, inflammation, and fibrosis after CCl4 compared to wild-type mice. NOX1 or NOX4 deficiency reduced lipid peroxidation and ROS production in mice with liver fibrosis. NOX1 and NOX4 deficiency are approximately equally effective in preventing liver injury in the mice. The NOX1/4 dual inhibitor GKT137831 suppressed ROS production as well as inflammatory and proliferative genes induced by lipopolysaccharide (LPS), platelet-derived growth factor (PDGF), or sonic hedgehog (Shh) in primary mouse HSCs. Furthermore, the mRNAs of proliferative and pro-fibrotic genes were downregulated in NOX1 and NOX4 knock-out activated HSCs (cultured on plastic for 5 days). Finally, NOX1 and NOX4 protein levels were increased in human livers with cirrhosis compared with normal controls. Thus, NOX1 and NOX4 signaling mediates the pathogenesis of liver fibrosis, including the direct activation of HSC.
Correction: Estimation of Distribution Overlap of Urn Models (2014)

A classical problem in statistics is estimating the expected coverage of a sample, which has had applications in gene expression, microbial ecology, optimization, and even numismatics. Here we consider a related extension of this problem to random samples of two discrete distributions. Specifically, we estimate what we call the dissimilarity probability of a sample, i.e., the probability of a draw from one distribution not being observed in k draws from another distribution. We show our estimator of dissimilarity to be a U -statistic and a uniformly minimum variance unbiased estimator of dissimilarity over the largest appropriate range of k. Furthermore, despite the non-Markovian nature of our estimator when applied sequentially over k, we show it converges uniformly in probability to the dissimilarity parameter, and we present criteria when it is approximately normally distributed and admits a consistent jackknife estimator of its variance. As proof of concept, we analyze V35 16S rRNA data to discern between various microbial environments. Other potential applications concern any situation where dissimilarity of two discrete distributions may be of interest. For instance, in SELEX experiments, each urn could represent a random RNA pool and each draw a possible solution to a particular binding site problem over that pool. The dissimilarity of these pools is then related to the probability of finding binding site solutions in one pool that are absent in the other.
Atrial natriuretic peptide inhibits growth of hepatoblastoma (HEP G2) cells by means of activation of clearance receptors (1993)

To investigate whether atrial natriuretic factor regulates the growth of hepatocytes and to determine the receptor subtype involved in such modulation, we studied the effect of atrial natriuretic factor 103-126 and clearance receptor binding analogs of atrial natriuretic factor, (des-(Q116, S117, G118, L119, G120) atrial natriuretic factor 102-121 and des-(C105,121) atrial natriuretic factor 104-126) on growth of human hepatoblastoma cells. Atrial natriuretic factor 103-126 and des-(Q116, S117, G118, L119, G120) atrial natriuretic factor 102-121 inhibited thymidine incorporation into human hepatoblastoma cells cultured in the presence of bovine serum albumin and epidermal growth factor but not in cells cultured in bovine serum albumin alone. Moreover, atrial natriuretic factor 103-126, des-(Q116, S117, G118, L119, G120) atrial natriuretic factor 102-121 and des-(C105,121) atrial natriuretic factor 104-126, in a concentration-dependent manner, inhibited thymidine incorporation and cell proliferation. As monitored by the ability of des-(Q116, S117, G118, L119, G120) atrial natriuretic factor 102-121 to displace 125I-labeled atrial natriuretic factor, epidermal growth factor increased the expression of cell surface clearance receptors. Epidermal growth factor also transiently increased the cellular content of atrial natriuretic factor clearance receptor messenger RNA without altering the levels of guanylyl cyclase-linked atrial natriuretic factor receptor messenger RNA levels. Maximal increase in atrial natriuretic factor clearance receptor messenger RNA coincided with the maximal increase in des-(Q116, S117, G118, L119, G120) atrial natriuretic factor 102-121-displaceable 125I-atrial natriuretic factor binding sites.(ABSTRACT TRUNCATED AT 250 WORDS)