gebhart/patrepeval huggingface dataset:
Formation of Di-Isodityrosine and Loss of Isodityrosine in the Cell Walls of Tomato Cell-Suspension Cultures Treated with Fungal Elicitors or H2O2 (1997)

About 84% of the hydroxyproline residues in a cell culture of tomato (Lycopersicon esculentum x Lycopersicon peruvianum) were present in phenol-inextractable (i.e. covalently wall-bound) material. Treatment of the cells with any of three fungal elicitors (wall fragments from Phytophthora megasperma and Pythium aphanidermatum and xylanase from Aureobasidium pullulans) or with 1 mM H2O2 had little effect on the quantity of phenolinextractable hydroxyproline per milligram of freeze-dried cells. However, each treatment induced a decrease in the content of phenol-inextractable isodityrosine (Idt) residues. Each treatment, except with the P. megasperma fragments, also induced an increase in phenol-inextractable di- (Di-Idt). The increase in Di-Idt partly accounted for the loss of Idt. We conclude that the elicitors and H2O2 acted to reinforce the existing cross-linking of cell wall (glyco)proteins by evoking oxidative coupling reactions to convert Idt to Di-Idt plus unidentified products. The promotion of cross-linking by elicitor treatment is proposed to be a defensive response that restricts the penetration of pathogens.
Local drug delivery catheters (1993)

The microporous catheter design offers improved functional characteristics when compared with the porous balloon for local intra-arterial drug delivery.
Electrocardiogram‐Based Predictors of Sudden Cardiac Death in Patients With Coronary Artery Disease (2011)

Current recommendations on which patients with coronary artery disease (CAD) should be offered an implantable cardioverter defibrillator for the primary prevention of sudden cardiac death (SCD) rely heavily on the presence of depressed left ventricular ejection fraction. Because the majority of SCD victims with CAD have preserved left ventricular function, additional cardiac investigations are likely to play an increasing role in the risk stratification of CAD patients. A number of studies have demonstrated that certain parameters on the traditional 12-lead electrocardiogram (ECG) and other ECG-based investigations (such as signal-averaged ECG, heart rate turbulence, T-wave alternans) can provide important information on the underlying cardiac substrate abnormality that may predispose to ventricular arrhythmias and SCD. This article reviews some of the evidence for these ECG-based tests as predictors of SCD in patients with CAD and addresses their advantages and limitations.
Alternative dosing schedules for irinotecan. (1998)

Most of the clinical experience with irinotecan (CPT-11 [Camptosar]) has been with either a weekly or an every-3-week schedule. Recent phase I trials have explored new routes and schedules of administration. One approach attempts to maximize dose frequency and intensity by giving irinotecan every 2 weeks. A phase I trial of this approach is now complete and has led to a phase II trial in patients with recurrent colorectal cancer. Data suggest that smaller doses of a topoisomerase I inhibitor administered repeatedly may result in greater antitumor activity than large doses administered intermittently. A phase I trial has been performed in adults in which irinotecan was administered daily for 5 consecutive days, followed by 2 days off, for 2 weeks out of 3. Similar trials are under way in children. Oral administration, another strategy that has undergone phase I testing, has several theoretical advantages:(1) The acidic pH of the stomach favors maintenance of irinotecan in the active lactone ring form. (2) Irinotecan is more rapidly and extensively converted to SN-38 by tissue carboxylesterases found in high concentrations in the gut and liver. (3) Low doses can be delivered over a protracted period. (4) The oral route enhances patient convenience. These alternative dosing schedules may facilitate integration of irinotecan into combination chemotherapy and combined-modality treatment regimens.
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats (2004)

Ablation or inhibition of phospholamban (PLN) has favorable effects in several genetic murine dilated cardiomyopathies, and we showed previously that a pseudophosphorylated form of PLN mutant (S16EPLN) successfully prevented progressive heart failure in cardiomyopathic hamsters. In this study, the effects of PLN inhibition were examined in rats with heart failure after myocardial infarction (MI), a model of acquired disease. S16EPLN was delivered into failing hearts 5 weeks after MI by transcoronary gene transfer using a recombinant adeno-associated virus (rAAV) vector. In treated (MI-S16EPLN, n = 16) and control (MI-saline, n = 18) groups, infarct sizes were closely matched and the left ventricle was similarly depressed and dilated before gene transfer. At 2 and 6 months after gene transfer, MI-S16EPLN rats showed an increase in left ventricular (LV) ejection fraction and a much smaller rise in LV end-diastolic volume, compared with progressive deterioration of LV size and function in MI-saline rats. Hemodynamic measurements at 6 months showed lower LV end-diastolic pressures, with enhanced LV function (contractility and relaxation), lowered LV mass and myocyte size, and less fibrosis in MI-S16EPLN rats. Thus, PLN inhibition by in vivo rAAV gene transfer is an effective strategy for the chronic treatment of an acquired form of established heart failure.
A 1.2 GHz programmable DLL-based frequency multiplier for wireless applications (2004)

A CMOS local oscillator using a programmable delayed-lock loop based frequency multiplier is present in this paper. The maximum measured output frequency is 1.2 GHz. The frequency of the output clock is 8/spl times/ to 10/spl times/ of an input reference clock between 100 to 150 MHz at simulation. No LC-tank is used in the proposed design such that the power dissipation as well as the active area is drastically reduced. The design is carried out by TSMC 1P5M 0.25 /spl mu/m CMOS process at 2.5 V power supply. The average lock time is optimally shortened by initializing the start-up voltage of the voltage-controlled delay tap line at the midway of the working range. Meanwhile, the power dissipation is 52.5 mW at 1.2 GHz output.
Evolving tRNASec for Efficient Canonical Incorporation of Selenocysteine (2014)

Bacterial selenocysteine incorporation occurs in response to opal stop codons and is dependent on the presence of a selenocysteine insertion sequence (SECIS) element, which recruits the selenocysteine specific elongation factor and tRNA(Sec) needed to reassign the UGA codon. The SECIS element is a stem-loop RNA structure immediately following the UGA codon and forms part of the coding sequence in bacterial selenoproteins. Although the site specific incorporation of selenocysteine is of great interest for protein engineering, the sequence constraints imposed by the adjoining SECIS element severely limit its use. We have evolved an E. coli tRNA(Sec) that is compatible with the canonical translation machinery and can suppress amber stop codons to incorporate selenocysteine with high efficiency. This evolved tRNA(Sec) allows the production of new recombinant selenoproteins containing structural motifs such as selenyl-sulfhydryl and diselenide bonds.
A 1.9 GHz wide-band IF double conversion CMOS integrated receiver for cordless telephone applications (2002)

A number of recent efforts have concentrated on highly-integrated radio receivers using a low-cost silicon process such as CMOS. This prototype monolithic CMOS receiver combines RF and baseband functionality by taking the carrier signal at the LNA input and producing a 10 b digital baseband waveform. A wide-band intermediate frequency double conversion (WBIFDC) architecture eliminates the need for external narrow-band IF filters.
Application of Monoclonal Antibodies in Functional and Comparative Investigations of Heavy-Chain Immunoglobulins in New World Camelids (2005)

ABSTRACT Of the three immunoglobulin G (IgG) isotypes described to occur in camelids, IgG2 and IgG3 are distinct in that they do not incorporate light chains. These heavy-chain antibodies (HCAbs) constitute approximately 50% of the IgG in llama serum and as much as 75% of the IgG in camel serum. We have produced isotype-specific mouse monoclonal antibodies (MAbs) in order to investigate the roles of HCAbs in camelid immunity. Seventeen stable hybridomas were cloned, and three MAbs that were specific for epitopes on the γ chains of llama IgG1, IgG2, or IgG3 were characterized in detail. Affinity chromatography revealed that each MAb bound its isotype in solution in llama serum. The antibodies bound to the corresponding alpaca IgGs, to guanaco IgG1 and IgG2, and to camel IgG1. Interestingly, anti-IgG2 MAbs bound three heavy-chain species in llama serum, confirming the presence of three IgG2 subisotypes. Two IgG2 subisotypes were detected in alpaca and guanaco sera. The MAbs detected llama serum IgGs when they were bound to antigen in enzyme-linked immunosorbent assays and were used to discern among isotypes induced during infection with a parasitic nematode. Diseased animals, infected with Parelaphostrongylus tenuis , did not produce antigen-specific HCAbs; rather, they produced the conventional isotype, IgG1, exclusively. Our data document the utility of these MAbs in functional and physiologic investigations of the immune systems of New World camelids.
The Tumor Suppressor Protein TSLC1 Is Involved in Cell-Cell Adhesion (2002)

TSLC1 is a tumor suppressor gene encoding a member of the immunoglobulin (Ig) superfamily. The significant homology of its extracellular domain with those of other Ig superfamily cell adhesion molecules (IgCAMs) has raised the possibility that TSLC1 participates in cell-cell interactions. In this study, the physiological properties of TSLC1 were investigated in Madin-Darby canine kidney (MDCK) cells expressing TSLC1 tagged with green fluorescent protein (GFP) as well as in the cells that express endogenous TSLC1. Biochemical analysis has revealed that TSLC1 is an N-linked glycoprotein with a molecular mass of 75 kDa and that it forms homodimers through cis interaction within the plane of the cell membranes. Confocal laser scanning microcopy of the cells expressing TSLC1 showed the localization patterns characteristic to adhesion molecules. At the beginning of cell attachment, TSLC1 accumulated in interdigitated structures at cell-cell boundaries, but, when cells reached a confluence, TSLC1 was distributed all along the cell membranes. In polarized cells, TSLC1 was recruited to the lateral membrane, implying trans interaction of TSLC1 between neighboring cells. In support of this notion, MDCK cells expressing TSLC1-GFP showed a significant level of cell aggregation in the absence or presence of Ca(2+) and Mg(2+). Taken together, these results indicate that TSLC1 mediates intracellular adhesion through homophilic interactions in a Ca(2+)/Mg(2+)-independent manner.
Adaptive filterbank multicarrier wireless systems for indoor environments (2003)

We investigate the use of modulated filterbanks in adaptive wireless multicarrier systems operating in indoor environments. The motivation for using filterbanks, as opposed to OFDM, is that these spectrally selective modulation filters can decrease the amount of interchannel interference without using lengthy cyclic prefixes which are necessary in OFDM. The design of the synthesis and analysis filterbanks, based on a single lowpass prototype filter, is presented. Furthermore, optimal subcarrier MMSE equalization, adaptive bit and power loading, as well as null subcarrier placement techniques are employed to enhance system throughput and bit error rate performance when operating in frequency selective channels. The performance of this system is studied and compared with an IEEE 802.11a compliant system, which is based upon OFDM modulation.
AII amacrine cells limit scotopic acuity in central macaque retina: A confocal analysis of calretinin labeling (1999)

We have used calretinin antibodies to label selectively the mosaic of AII amacrine cells in the macaque retina. Confocal analysis of double-labeled material indicated that AII dendrites spiral down around descending rod bipolar axons before enveloping the synaptic terminals. Processes from a previously observed dopaminergic plexus in the inner nuclear layer were observed to contact the somata of calretinin-positive AII somata. Intracellular neurobiotin injection revealed that AII amacrine cells are tracer coupled to other AII amacrine cells and to some unidentified cone bipolar cells. An analysis of the retinal distribution of macaque AII amacrine cells, including an area in and around the fovea, showed a peak density of approximately 5,000 cells/mm(2) at an eccentricity of 1.5 mm. Staining of AII amacrine cells in central retina with antibodies to calretinin was confirmed by confocal microscopy. These results indicate that calretinin antibodies can be used to label the AII amacrine cell population selectively and that primate AII amacrine cells share many of the features of previously described mammalian AII amacrine cells. The peak AII cell density closely matched the peak sampling rate of scotopic visual acuity. Calculations suggest that, in central macaque retina, where midget ganglion cells are more numerous, AII amacrine cells form the limit of scotopic visual acuity (Wässle et al. [1995] J. Comp. Neurol. 361:537-551). As the ganglion cell density falls rapidly away from the fovea, there is a cross-over point at around 15 degrees eccentricity that matches the inflection point in a psychophysically derived plot of scotopic visual acuity versus eccentricity (Lennie and Fairchild [1994] Vision Res. 34:477-482). The correspondence between the anatomic and psychophysical data supports our interpretation that the anatomic sampling rate of AII amacrine cells limits central scotopic acuity.
Abstract 19088: The Plasminogen Receptor, Plg-RKT, Regulates Metabolic Homeostasis and Promotes Healthy Adipose Function (2016)

Introduction: Inhibition of the plasminogen activation system is linked to adipose fibrosis and insulin resistance in response to a high fat diet. However, the role of molecules that promote plasmi...
Design and Synthesis of Glycomimetic Prototypes - A Model Sialyl LewisxLigand for E-Selectin (1994)

A prototypical model compound intended as a potential glycomimetic for sialyl Lewisx has been synthesized using the α-sialyl and α-fucosyl units anchored on a pentaerythritol template.
Studies of molybdenum compounds. 1. Synthesis and structure of dioxo(dimethyl)2,2'-bipyridylmolybdenum(VI), prototype of a new class of organomolybdenum(VI) compounds (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies of molybdenum compounds. 1. Synthesis and structure of dioxo(dimethyl)2,2'-bipyridylmolybdenum(VI), prototype of a new class of organomolybdenum(VI) compoundsGerhard N. Schrauzer, Laura A. Hughes, Norman Strampach, Paul R. Robinson, and Elmer O. SchlemperCite this: Organometallics 1982, 1, 1, 44–47Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/om00061a008https://doi.org/10.1021/om00061a008research-articleACS PublicationsRequest reuse permissionsArticle Views273Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Scalable Web server architectures (2002)

A scalable web server architecture is key to enabling WWW sites to handle the ever increasing traffic loads. There is empirical evidence that, for the current generation of web server applications, multiprocessor platforms do not provide the needed scalability to handle large traffic volumes. This is primarily due to the fact that current TCP/IP implementations are single-threaded which severely limits the multiprocessor speedup for HTTP server applications. Therefore a distributed architecture consisting of independent servers sharing the load is more appropriate for implementing a scalable web server. Most current distributed server platforms typically use some form of Round-Robin or weighted Round-Robin implemented using the DNS server. This approach for distributing the load requires each HTTP server to handle requests for all the data stored at the site which implies that either each server must store its own copy of all the data available at the site or it must access the data from other HTTP servers or some dedicated back-end file or database servers thus generating significant back-end traffic. Neither of these options scale effectively because they lead to bottlenecks in the LAN or back-end servers or require significant additional resources. The "redirection-based" hierarchical server architecture eliminates bottlenecks in the server complex and allows for hardware to be added seamlessly to handle increases in load. In this approach, two levels of servers are used: redirection servers and normal HTTP servers. Data are partitioned according to their content and stored on different HTTP servers. Redirection servers are used to distribute the users' requests to the corresponding HTTP servers using the redirection mechanism supported by the HTTP protocol. This approach is completely transparent to the user, allows for intelligent distribution of load among servers, and achieves better caching efficiency compared with other load balancing schemes.
Rationalizing the Strength of Hydrogen-Bonded Complexes. Ab Initio HF and DFT Studies (2002)

A comparative study of the relative stabilities of 17 multiply hydrogen-bonded complexes has been carried out using ab initio Hartree−Fock and density functional methods at the HF/6-311(d,p) and B3LYP/6-311(d,p) levels, respectively. Predicted hydrogen-bond geometries, relative stabilities, solvent and structural effects, and electrostatic potential contours are discussed in conjunction with experimental data. The B3LYP method, which secures a better agreement of the optimized geometries with the available X-ray data, has also been applied to calculate the gas-phase free energies and enthalpies. The computations reveal that the frequently used incremental approach, which takes into consideration the primary and secondary electrostatic interactions, can often be deceptive in interpreting the stabilities of the multiply hydrogen-bonded dimers. The explanation that reduced entropy enhances the stability of dimers involving intramolecular hydrogen bonds in their monomeric parts compared to similar structures lacking such bonds has also been found to be misleading. A comparison of the calculated results with available experimental stabilities measured in CHCl3 solutions shows that water present in the solvent may cause dramatic changes in relative stabilities. Electrostatic potential contours calculated at the B3LYP/6-311(d,p) level provide a useful qualitative explanation of the stability differences in the investigated complexes.
Photothermal and photoacoustic Raman cytometry in vitro and in vivo (2010)

An integrated Raman-based cytometry was developed with photothermal (PT) and photoacoustic (PA) detection of Raman-induced thermal and acoustic signals in biological samples with Raman-active vibrational modes. The two-frequency, spatially and temporally overlapping pump-Stokes excitation in counterpropagating geometry was provided by a nanosecond tunable (420-2300 nm) optical parametric oscillator and a Raman shifter (639 nm) pumped by a double-pulsed Q-switched Nd:YAG laser using microscopic and fiberoptic delivery of laser radiation. The PA and PT Raman detection and imaging technique was tested in vitro with benzene, acetone, olive oil, carbon nanotubes, chylomicron phantom, and cancer cells, and in vivo in single adipocytes in mouse mesentery model. The integration of linear and nonlinear PA and PT Raman scanning and flow cytometry has the potential to enhance its chemical specificity and sensitivity including nanobubble-based amplification (up to 10- fold) for detection of absorbing and nonabsorbing targets that are important for both basic and clinically relevant studies of lymph and blood biochemistry, cancer, and fat distribution at the single-cell level.
Developing grey-box model to diagnose asphaltene stability in crude oils: Application of refractive index (2016)

Asphaltene precipitation can cause serious problems in petroleum industry while diagnosing the asphaltene stability conditions in crude oil system is still a challenge and has been subject of many investigations. To monitor and diagnose asphaltene stability, high performance intelligent approaches based bio-inspired science like artificial neural network which have been optimized by various optimization techniques have been carried out. The main purpose of the implemented optimization algorithms is to decide high accurate interconnected weights of proposed neural network model. The proposed intelligent approaches are examined by using extensive experimental data reported in open literature. Moreover, to highlight robustness and precision of the addressed approaches, two different regression models have been developed and results obtained from the aforementioned intelligent models and regression approaches are compared with the corresponding refractive index data measured in laboratory. Based on the results, hybrid of genetic algorithm and particle swarm optimization have high performance and average relative absolute deviation between the model outputs and the relevant experimental data was found to be less than 0.2%. Routs from this work indicate that implication of HGAPSO-ANN in monitoring refractive index can lead to more reliable estimation of addressed issue which can lead to design of more reliable phase behavior simulation and further plans of oil production.