gebhart/patrepeval huggingface dataset:
Modern control engineering (1970)

From the Publisher:
This comprehensive treatment of the analysis and design of continuous-time control systems provides a gradual development of control theoryand shows how to solve all computational problems with MATLAB. It avoids highly mathematical arguments, and features an abundance of examples and worked problems throughout the book. Chapter topics include the Laplace transform; mathematical modeling of mechanical systems, electrical systems, fluid systems, and thermal systems; transient and steady-state-response analyses, root-locus analysis and control systems design by the root-locus method; frequency-response analysis and control systems design by the frequency-response; two-degrees-of-freedom control; state space analysis of control systems and design of control systems in state space.
Small scale treatment systems (1993)

Inadequate or improper collection and disposal of liquid waste leads to pollution of surface and groundwater and pose major threats to public health and community well being. The emergence of big cities and industries has typically demanded centralised collection, treatment and disposal systems for liquid wastes. Most cities in developed countries have reticulated sewerage systems which collect and treat the wastes to acceptable standards. In fact a majority of municipal authorities and public health engineers consider the reticulated sewerage system with a modern high technology treatment system and disposal facility as the only suitable approach to liquid waste for a municipal area. Such systems require continuous and plentiful supply of water along with all the capital intensive infrastructure necessary for treatment and these conditions are not always easily fulfilled.&#13;\n&#13;\nDeveloping countries and smaller more isolated communities find the cost of providing such facilities to achieve the necessary public health requirements prohibitively high. In rural and semi-rural and particularly remote areas a centralised system generally costs much more on a per capita basis than a locally based independent system of liquid waste .disposal. In this context there are now a variety of options for wastewater treatment, disposal and reuse. Such systems can produce an effluent quality equal to or better than a conventional treatment plant.&#13;\n&#13;\nThe major concern for municipal authorities and public health engineers is to dispose of the waste with minimum nuisance and health problems and at a price that can be managed within capital and recurrent budgets. From the point of view of a local community there are questions of the affordability of the chosen system for them, but also wider and deeper issues of community development and control over technologies that have the potential to influence the dynamics, form and autonomy of the society into which they are introduced.&#13;\n&#13;\nThere are now growing environmental and social pressures to consider all the possibilities for reusing wastes and to begin introducing systems which are of a sustainable nature. &#13;\n&#13;\nThis paper will discuss the criteria to be considered in general in the process of selection of a particular technology and then explain a few technologies which are approved to be used in Western Australia.
Crystal structure of the collagen triple helix model [(Pro‐Pro‐Gly) 10 ] 3 (2002)

The first report of the full-length structure of the collagen-like polypeptide [(Pro-Pro-Gly)(10)](3) is given. This structure was obtained from crystals grown in a microgravity environment, which diffracted up to 1.3 A, using synchrotron radiation. The final model, which was refined to an R(factor) of 0.18, is the highest-resolution description of a collagen triple helix reported to date. This structure provides clues regarding a series of aspects related to collagen triple helix structure and assembly. The strict dependence of proline puckering on the position inside the Pro-Pro-Gly triplets and the correlation between backbone and side chain dihedral angles support the propensity-based mechanism of triple helix stabilization/destabilization induced by hydroxyproline. Furthermore, the analysis of [(Pro-Pro-Gly)(10)](3) packing, which is governed by electrostatic interactions, suggests that charges may act as locking features in the axial organization of triple helices in the collagen fibrils.
An anti-CD19 antibody inhibits the interaction between P-glycoprotein (P-gp) and CD19, causes P-gp to translocate out of lipid rafts, and chemosensitizes a multidrug-resistant (MDR) lymphoma cell line (2004)

We have previously demonstrated that an anti-CD19 monoclonal antibody (MAb; HD37) inhibits the function of the P-glycoprotein (P-gp) pump in a multidrug-resistant (MDR) B-lymphoma cell line, Namalwa/MDR1, and that this effect is not due to the recognition of a cross-reactive epitope on P-gp. In this study, we have used the same cell line to define the mechanisms responsible for the effect of HD37 on the P-gp pump. Using fluorescence resonance energy transfer (FRET), we show that CD19 and P-gp are constitutively associated in cells. In the absence of treatment with anti-CD19, 40% of P-gp molecules expressed by Namalwa/MDR1 cells reside in the low-density lipid (ie, cholesterol-rich) microdomains (lipid rafts). Following treatment of the cells with HD37 and disruption of the interactions between P-gp and CD19, P-gp translocated out of lipid rafts and CD19 translocated into lipid rafts. The effect of chemosensitization on Namalwa/MDR1 cells was specific for CD19; an anti-CD22 MAb had no such effect, although the cells express CD22. These results suggest that anti-CD19 might chemosensitize P-gp(+) cells by interfering with interactions between CD19 and P-gp, rapidly resulting in the translocation of P-gp into a compartment on the plasma membrane where it is no longer active.
Review of Azithromycin Ophthalmic 1% Solution (AzaSite®) for the Treatment of Ocular Infections (2012)

AzaSite(®) (azithromomycin 1.0%) ophthalmic solution was approved in 2007 by the US Food and Drug Administration (FDA) as the first commercially available formulation of ophthalmic azithromycin for the treatment of bacterial conjunctivitis. AzaSite(®) utilizes a vehicle delivery system called DuraSite(®), which stabilizes and sustains the release of azithromycin to the ocular surface, leading to a longer drug residence time, less frequent dosing, and an increase in patient compliance. AzaSite(®) is a broad spectrum antibiotic, effective against Gram-positive, Gram-negative, and atypical bacteria. AzaSite(®) has been studied for the treatment of ocular conditions beyond its clinical indication. A number of clinical studies have evaluated its efficacy and safety in the management of ocular conditions such as bacterial conjunctivitis and blepharitis on both the pediatric and adult populations. This article aims to evaluate the peer-reviewed published literature on the use of azithromycin 1.0% ophthalmic for current and possible future ophthalmic uses.
Complement, cytokines, and adhesion molecule expression in inflammatory reactions. (1999)

Directional emigration of neutrophils is the hallmark of phlogistic processes. The involved regulatory mechanisms include complement activation products, cytokines, adhesion molecules, and their respective counter receptors. In this article, we discuss the role of these mediators in initiation, development, and containment of acute inflammatory responses in in vitro and in vivo models, showing interactions between a network of proinflammatory and anti-inflammatory effectors. A major focus deals with the effects of complement on activation of the vascular endothelium. In addition, the role of interleukins in the regulation of inflammatory responses is described.
Influence of energy density on metallurgy and properties in metal additive manufacturing (2017)

Fabricating metallic components for highly specialised industries such as automotive and aerospace has become the main focus of additive manufacturing (AM) due to its many advantages over traditional processes. This review initially outlines current AM techniques for processing metallic components, particularly on ‘powder bed fusion’ and ‘directed energy deposition’ categories. Various solidification and metallurgical aspects, microstructure and properties of fabricated parts are described in subsequent sections. In addition, the influence of energy density on metallurgy, microstructure and mechanical properties is addressed. The need to establish processing maps for various materials and techniques, and the challenges currently faced in metal AM are then highlighted. The final section provides an outlook for the future of research in AM of metals.
The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin (2011)

The recent discovery of a new CD4+ T cell subset, Th17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic immune-mediated diseases. Particularly in tissues that interface with the microbial environment-such as the intestinal and respiratory tracts and the skin-where most of the Th17 cells in the body reside, dysregulated immunity to self (or the extended self, the diverse microbiota that normally colonize these tissues) can result in chronic inflammatory disease. In this review, we focus on recent advances in the biology of the Th17 pathway and on genome-wide association studies that implicate this immune pathway in human disease involving these tissues.
First synthesis of 1,2,3-triazolo-linked (1,6)-α-d-oligomannoses (triazolomannoses) by iterative Cu(i)-catalyzed alkyne–azide cycloaddition (2006)

The iterative copper(I)-catalyzed cycloaddition (rt or microwave) between an ethynyl alpha-C-mannoside and alkyl 6-azido-alpha-C-mannoside derivatives was suited to the (1,6)-ligation between alpha-D-mannose units through 1,4-disubstituted triazole bridges, thus resulting in the formation of linear oligomers (80-90% yield) with alternating triazole and mannose fragments up to a triazolo-pentamannose derivative.
Synthesis of Iminoquinones from Anilines Using IBX in DMSO (2007)

An efficient and convenient procedure for the preparation of 2-amino-(1,4)-benzoquinone-4-phenylimides from anilines using a λ5-iodane-1-hydroxy-1,2-benziodoxol-3(1H)-one-1-oxide (IBX) oxidation in dimethyl sulfoxide is described. This protocol offers a general approach to compounds consisting of an iminoquinone moiety with a wide range of functional groups. A single electron transfer (SET) process was postulated to explain the oxidation pathway.
Preparation and Characterization of Reconstituted Lipid–Synthetic Polymer Discoidal Particles (2015)

Discoidal high-density lipoproteins generated by the apolipoprotein-mediated solubilization of membrane lipids in vivo can be reconstituted with phospholipids and apolipoproteins in vitro. Recently, it has been reported that such particles can be prepared using the hydrolyzed acid form of styrene-maleic anhydride copolymer (SMAaf) instead of apolipoproteins, but characterization of its physicochemical properties has remained less elucidated. In the present study, with the aim of applying SMAaf-based lipid nanoparticles as novel delivery vehicles of drugs and/or imaging agents, we investigated the preparation conditions and evaluated the physicochemical properties of lipid-SMAaf complexes. SMAaf induced spontaneous turbidity clearance of dimyristoylphosphatidylcholine (DMPC) vesicles accompanied by the formation of smaller particles not only at the phase transition temperature of DMPC but also above it. Such reductions in the turbidity were not observed with some other amphiphilic synthetic polymers tested under the same experimental conditions. Size exclusion chromatography analyses showed that homogeneously sized particles were prepared at lipid to SMAaf weight ratios of less than 1/1.5. Dynamic light scattering and transmission electron microscopy revealed that gel-filtered DMPC-SMAaf complexes were approximately 8-10 nm in diameter and discoidal in shape. The DMPC-SMAaf complexes were relatively stable even after lyophilization but were sensitive to pH changes. Fluorescence techniques demonstrated that the gel to liquid-crystalline phase transition temperature of DMPC in the discoidal complexes broadened significantly relative to that of liposomes, despite their common bilayer structure, which is a typical feature of discoidal lipid nanoparticles. These results provide fundamental insights into discoidal SMAaf-based lipid nanoparticles for the development of novel delivery vehicles.
cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. (1989)

A 90-kDa surface glycoprotein was previously isolated and shown to be required for infection by the "major" group of human rhinovirus (HRV) serotypes. In the present work, the amino acid sequence of the receptor protein was obtained from CNBr and tryptic peptides. Using degenerate oligonucleotides predicted from the peptide sequences, we identified four cDNA clones that encode a 3-kilobase mRNA. The clones were ligated, subcloned in a simian virus 40 expression vector, and used to transfect receptor-negative Vero (monkey) cells. Results showed that transfected cells expressed receptor molecules capable of binding HRV and a monoclonal antibody which recognizes the major group HRV receptor. The cloned receptor cDNA encoded a protein with a sequence nearly identical to that of the intercellular adhesion molecule 1 (ICAM-1), indicating that the two surface proteins are one and the same. Both proteins have identical mass, carbohydrate composition, and tissue distribution. In addition, major group receptors on HeLa cells could be induced with various cytokines in a manner similar to the ICAM-1 ligand. A similar induction of the HRV "minor" group receptor was not observed.
A Single–Chip 10-Band WCDMA/HSDPA 4-Band GSM/EDGE SAW-less CMOS Receiver With DigRF 3G Interface and ${+}$90 dBm IIP2 (2009)

This paper describes the design and performance of a 90 nm CMOS SAW-less receiver with DigRF interface that supports 10 WCDMA bands (I, II, III, IV, V, VI, VIII, IX, X, XI) and 4 GSM bands (GSM850, EGSM900, DCS1800, PCS1900). The receiver is part of a single-chip SAW-less transceiver reference platform IC for mass-market smartphones, which has been designed to meet Category 10 HSDPA (High Speed Downlink Packet Access) requirements. The novel receiver core consists of a single-stage transconductance amplifier (TCA) with large gain control range, a current commutating passive mixer enhanced for automatic on chip IIP2 calibration with 25% duty-cycle LO injection and threshold adjust, and current-input complex Direct Coupled Filter (DCF). The low noise TCAs are designed without inductive loads to save area. A self-contained on chip automatic IIP2 calibration system with algorithm routine, implemented in firmware, is used to optimize IIP2 performance. This topology eliminates the external LNA, inter-stage SAW filter and transimpedance amplifier (TZA) in conventional WCDMA designs and results in current drain and die area savings as well as improved noise. The 25% duty-cycle LO injection, with threshold adjustment, into a current driven passive double-balanced mixer results in 3 dB additional gain, lower noise figure and lower intermodulation distortion. Large signal blocking and 1/f noise performance are improved significantly by eliminating the 0 and 180deg LO signal crossover at the mixer. The full receiver achieves 2.2 dB/2.39 dB simplex/duplex NF (with - 24.5 dBm TX leakage), > 90 dBm complex two-tone IIP2, 60 dB gain and - 1/+ 5 dBm half/full-duplex image IIP3. The receiver core consumes only 15.1 mA from a 1.5 V supply.
Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008)

Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that IR is associated with a state of chronic low-grade inflammation, and several mediators released from various cell types, including immune cells and adipocytes, have been identified as being involved in the development of IR. Among those are several pro-inflammatory cytokines such as tumor necrosis factor-alpha(TNF-alpha), interleukin (IL)-1, IL-6, and various adipocytokines. Furthermore, several transcription factors and kinases such as c-Jun N-terminal kinase (JNK) and inhibitor of kappa B kinase-beta (IKKbeta), a kinase located proximal of nuclear factor-kappaB (NF-kappaB), participate in this process. Hepatocyte-specific overexpression of NF-kappaB is associated with IR and can mimic all features of fatty liver disease. Whereas the evidence for an important role of many pro-inflammatory pathways in IR in in vitro and animal studies is overwhelming, data from interventional studies in humans to prove this concept are still minor. As a complex network of inflammatory cytokines, adipocytokines, transcription factors, receptor molecules, and acute-phase reactants are involved in the development of IR, new therapeutic approaches in IR-related diseases will be based on a better understanding of their complex interactions.
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase (2001)

The medicinal properties of marijuana have been recognized for centuries, but clinical and societal acceptance of this drug of abuse as a potential therapeutic agent remains fiercely debated. An attractive alternative to marijuana-based therapeutics would be to target the molecular pathways that mediate the effects of this drug. To date, these neural signaling pathways have been shown to comprise a cannabinoid receptor (CB(1)) that binds the active constituent of marijuana, tetrahydrocannabinol (THC), and a postulated endogenous CB(1) ligand anandamide. Although anandamide binds and activates the CB(1) receptor in vitro, this compound induces only weak and transient cannabinoid behavioral effects in vivo, possibly a result of its rapid catabolism. Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH(-/-)) are severely impaired in their ability to degrade anandamide and when treated with this compound, exhibit an array of intense CB(1)-dependent behavioral responses, including hypomotility, analgesia, catalepsy, and hypothermia. FAAH(-/-)-mice possess 15-fold augmented endogenous brain levels of anandamide and display reduced pain sensation that is reversed by the CB(1) antagonist SR141716A. Collectively, these results indicate that FAAH is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception. FAAH may therefore represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders.
SUBCLINICAL INFECTION OF DOGS BY CANINE-ADAPTED MEASLES VIRUS EVIDENCED BY THEIR SUBSEQUENT IMMUNITY TO CANINE DISTEMPER VIRUS (1961)

Moura, Roberto A. (Chas. Pfizer and Company, Inc., Terre Haute, Ind.) and Joel Warren. Subclinical infection of dogs by canine-adapted measles virus evidenced by their subsequent immunity to canine distemper virus. J. Bacteriol. 82:702-705. 1961.-Young dogs were inoculated with virulent measles virus which had been adapted to canine kidney or human amnion cell culture. None of the animals showed any clinical symptoms nor could virus be isolated from the blood, although measles-neutralizing and complement-fixing antibodies developed during convalescence. All dogs failed to develop antibody to canine distemper. However, when these and normal control animals were subsequently inoculated intracerebrally with virulent distemper virus, each of the controls succumbed to typical symptoms, whereas all of the measles-immune dogs survived. These results suggest that the cross-protection conferred by measles against canine distemper virus infection involves factors other than humoral antibody. The immunity persists for a considerable length of time.
Mesoscopic Au “Meatball” Particles (2008)

Sub-micrometer meatball-like Au particles provide a very interesting mesoscopic regime in which their optical responses are determined by both the mesoscopic size and the particle's nanoscale surface roughness. The unique optical properties of these mesoscopic particles and particle arrays hold great potential in chemical sensing and spectroscopic applications.
The Kidney Plays A Major Role in the Hyperammonemia Seen After Simulated or Actual Gi Bleeding in Patients With Cirrhosis (2003)

Upper gastrointestinal (UGI) bleeding in cirrhosis is associated with enhanced ammoniagenesis, the site of which is thought to be the colon. The aims of this study were to evaluate interorgan metabolism of ammonia following an UGI bleed in patients with cirrhosis. Study 1: UGI bleed was simulated in 8 patients with cirrhosis and a transjugular intrahepatic portasystemic stent-shunt (TIPSS) by intragastric infusion of an amino acid solution that mimics the hemoglobin molecule. We sampled blood from the femoral artery and a femoral, renal, portal, and hepatic vein for 4 hours during the simulated bleed and measured plasma flows across these organs. Study 2: In 9 cirrhotic patients with an acute UGI bleed that underwent TIPSS insertion, blood was sampled from an artery and a hepatic, renal, and portal vein, and plasma flows were measured. Study 1: During the simulated bleed, arterial concentrations of ammonia increased significantly (P =.002). There was no change in ammonia production from the portal drained viscera, but renal ammonia production increased 6-fold (P =.008). In contrast to an unchanged ammonia removal by the liver, a significant increase in muscle ammonia removal was observed. Study 2: In patients with an acute UGI bleed, ammonia was only produced by the kidneys (572 [184] nmol/kg bw/min) and not by the splanchnic area (-121 [87] nmol/kg bw/min). In conclusion, enhanced renal ammonia release has an important role in the hyperammonemia that follows an UGI bleed in patients with cirrhosis. During this hyperammonemic state, muscle is the major site of ammonia removal.
Lipopolysaccharides from Periodontopathic BacteriaPorphyromonas gingivalisandCapnocytophaga ochraceaAre Antagonists for Human Toll-Like Receptor 4 (2002)

Toll-like receptors (TLRs) 2 and 4 have recently been identified as possible signal transducers for various bacterial ligands. To investigate the roles of TLRs in the recognition of periodontopathic bacteria by the innate immune system, a Chinese hamster ovary (CHO) nuclear factor-kappaB (NF-kappaB)-dependent reporter cell line, 7.7, which is defective in both TLR2- and TLR4-dependent signaling pathways was transfected with human CD14 and TLRs. When the transfectants were exposed to freeze-dried periodontopathic bacteria, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Capnocytophaga ochracea, and Fusobacterium nucleatum, and a non-oral bacterium, Escherichia coli, all species of the bacteria induced NF-kappaB-dependent CD25 expression in 7.7/huTLR2 cells. Although freeze-dried A. actinomycetemcomitans, F. nucleatum, and E. coli also induced CD25 expression in 7.7/huTLR4 cells, freeze-dried P. gingivalis did not. Similarly, lipopolysaccharides (LPS) extracted from A. actinomycetemcomitans, F. nucleatum, and E. coli induced CD25 expression in 7.7/huTLR4 cells, but LPS from P. gingivalis and C. ochracea did not. Furthermore, LPS from P. gingivalis and C. ochracea attenuated CD25 expression in 7.7/huTLR4 cells induced by repurified LPS from E. coli. LPS from P. gingivalis and C. ochracea also inhibited the secretion of interleukin-6 (IL-6) from U373 cells, the secretion of IL-1beta from human peripheral blood mononuclear cells, and ICAM-1 expression in human gingival fibroblasts induced by repurified LPS from E. coli. These findings indicated that LPS from P. gingivalis and C. ochracea worked as antagonists for human TLR4. The antagonistic activity of LPS from these periodontopathic bacteria may be associated with the etiology of periodontal diseases.