gebhart/patrepeval huggingface dataset:
A field investigation of causes of abortion in dairy cattle. (1990)

Cases of abortion on dairy farms on the Lancashire/Cumbria border were investigated by means of a systematic diagnostic procedure, using the facilities of a veterinary practice's laboratory, and the Ministry of Agriculture, Fisheries and Food veterinary investigation centre. Among approximately 3600 animals, 149 abortions were investigated on 54 farms in two years, an annual abortion rate of 2 per cent. A diagnosis was made in 34 per cent of the cases, based on a pathological examination of aborted material and bacteriological and serological findings. The most common pathogens associated with abortion were bovine viral diarrhoea virus (39 cases), bacterial or fungal infections (20 cases), infectious bovine rhinotracheitis virus (19 cases), and Leptospira hardjo (18 cases), either as single or multiple infections.
Production and regulation of monocyte chemoattractant protein-1 in lipopolysaccharide- or monosodium urate crystal-induced arthritis in rabbits: roles of tumor necrosis factor alpha, interleukin-1, and interleukin-8. (1998)

The production of monocyte chemoattractant protein-1 (MCP-1) and its regulation by TNFalpha, IL-1, and IL-8 were investigated in two rabbit models of arthritis induced by intra-articular injection of lipopolysaccharide (LPS) or monosodium urate (MSU) crystals. We first prepared recombinant rabbit MCP-1 and antibodies and then developed an immunoassay. The immunoassay detected 3 pg/ml rabbit MCP-1 and did not cross-react with other rabbit chemokines such as IL-8 or GRO. MCP-1 was first detected in synovial fluid (SF) at 1 hour, and peaked at 4 or 2 hours after the injection of LPS or MSU crystals, respectively. Immunohistochemically, MCP-1 was detected in synovial lining cells and infiltrating neutrophils. The amounts of MCP-1 detected in SF from neutrophil-depleted rabbits were similar to those in normal rabbits, suggesting that synovial lining cells were the main source of MCP-1 detected in SF. The peak level of MCP-1 in SF after LPS-injection was inhibited by 57% with anti-TNFalpha mAb and by 41% with IL-1 receptor antagonist (IL-1Ra). Coadministration of anti-TNFalpha mAb and IL-1Ra inhibited 90% of MCP-1 production. In contrast, the peak level of MCP-1 in SF after MSU crystal-injection was not affected by any cytokine inhibitor, but was reduced by 52% with coadministration of anti-TNFalpha mAb and IL-1Ra. Anti-IL-8 IgG had no effect on the production of MCP-1 in either model. Thus, the production of MCP-1 in LPS-induced arthritis was mostly regulated by TNFalpha and IL-1, whereas half the extent of MCP-1 production in MSU crystal-induced arthritis was independent of TNFalpha or IL-1. IL-8 does not seem to regulate the production of MCP-1 in SF either directly or indirectly. Finally, administration of neutralizing anti-MCP-1 antibody inhibited LPS- and MSU crystal-induced monocyte infiltration by 58.4% and 44.9%, respectively, suggesting that synovial production of MCP-1 plays an important role in the recruitment of monocytes in these arthritis models.
Detection of Philadelphia chromosome-positive cells by the polymerase chain reaction following bone marrow transplant for chronic myelogenous leukemia (1989)

Sixteen patients treated by allogeneic bone marrow transplantation (BMT) for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr/abl-specific RNA transcripts at various time points after BMT. In reconstitution experiments, one CML cell per million normal mononuclear cells could be detected by direct agarose gel visualization of a bcr/abl-specific band following PCR. Bcr/abl message was found in ten out of 16 patients post-BMT. PCR- positive bcr/abl was present only transiently in three patients and correlated with relapse in three. One patient died in clinical remission, while two patients remain in remission despite persistence of bcr/abl-positive abl-positive cells at 180 days. Long-term follow-up of bcr/abl-positive patients in clinical remission may provide insight into the fate or residual Ph+ cells after BMT. This approach may aid in the identification of high-risk patients likely to relapse post-BMT.
Image interpretation and object recognition in manufacturing (1991)

Some of the characteristics and peculiarities of the vision problems in the manufacturing domain are examined. Work in developing and experimenting with a framework for intelligent interpretation of images in manufacturing applications is presented. The framework encompasses the issues surrounding the knowledge representation, reasoning and control, and maintenance of consistency, and incorporates three types of knowledge: knowledge about objects, about relations, and about reasoning and problem solving. Knowledge representation in this system is described, and the issues of reasoning, control, and determining model-to-image transformations are addressed. An example that involves determining the identity, position, and orientation of a part is provided. A brief review of related work in knowledge-based image interpretation and CAD-based vision is included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Antiarrhythmic agents. 2-, 3-, and 4-Substituted benzylamines (1975)

The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.
The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis (2008)

Our results demonstrate that PGE(2) prevents myocardial apoptosis induced by DOX. This protection requires the activation of the prosurvival pathways of Stat3 and ERK1/2.
Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages. (1988)

We have used a serum-free culture system for enriched human hemopoietic progenitors to analyze the developmental stages and lineage specificities of the human hemopoietic colony-stimulating factors. None of the individual factors alone efficiently supported hemopoietic colony formation. Neither interleukin 3 nor granulocyte/macrophage-colony-stimulating factor alone or in combination effectively supported proliferation of progenitor cells. However, when combined with granulocyte-colony-stimulating factor or erythropoietin, these factors yielded neutrophil colonies or erythroid bursts, respectively. Serial observations of interleukin 3-supported cultures revealed sequential emergence and subsequent degeneration of clusters of cells. These observations suggest that the primary targets of interleukin 3 and granulocyte/macrophage-colony-stimulating factor are multipotent progenitors at the early stages of development rather than cells in the terminal process of maturation.
Personalizing Search on Shared Devices (2015)

Search personalization tailors the search experience to individual searchers. To do this, search engines construct interest models comprising signals from observed behavior associated with ma-chines, often via Web browser cookies or other user identifiers. However, shared device usage is common, meaning that the activities of multiple searchers may be interwoven in the interest models generated. Recent research on activity attribution has led to methods to automatically disentangle the histories of multiple searchers and correctly ascribe newly-observed search activity to the correct per-son. Building on this, we introduce attribution-based personalization (ABP), a procedure that extends traditional personalization to target individual searchers on shared devices. Activity attribution may improve personalization, but its benefits are not yet fully understood. We present an oracle study (with perfect knowledge of which searchers perform each action on each machine) to under-stand the effectiveness of ABP in predicting searchers' future interests. We utilize a large Web search log dataset containing both per-son identifiers and machine identifiers to quantify the gain in personalization performance from ABP, identify the circumstances under which ABP is most effective, and develop a classifier to determine when to apply it that yields sizable gains in personalization performance. ABP allows search providers to personalize experiences for individuals rather than targeting all users of a device collectively.
Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit. (1994)

Mimetic peptides capable of selectively disrupting protein-protein interactions represent potential therapeutic agents for inhibition of viral and cellular enzymes. This approach was first suggested by the observation that the peptide YAGAVVNDL, corresponding to the carboxyl-terminal 9 amino acids of the small subunit of ribonucleotide reductase of herpes simplex virus, specifically inhibited the viral enzyme in vitro. Evaluation and use of this peptide as a potential antiviral agent has, however, been thwarted by its failure to inhibit virus replication in vivo, presumably because the peptide is too large to enter eukaryotic cells unaided. Here, we show that the nontoxic B subunit of Escherichia coli heat-labile enterotoxin can be used as a recombinant carrier for the receptor-mediated delivery of YAGAVVNDL into virally infected cells. The resultant fusion protein specifically inhibited herpes simplex virus type 1 replication and ribonucleotide reductase activity in quiescent Vero cells. Preincubation of the fusion protein with soluble GM1 ganglioside abolished this antiviral effect, indicating that receptor-mediated binding to the target cell is necessary for its activity. This provides direct evidence of the usefulness of carrier-mediated delivery to evaluate the intracellular efficacy of a putative antiviral peptide.
Address line-assisted switching of vertical magnetoresistive random access memory cells (2005)

Vertical magnetoresistive random access memory (VMRAM) is a high-density, nonvolatile memory that employs current perpendicular to the plane to switch soft (read) and hard (write) magnetic layers of a giant-magnetoresistive memory element. VMRAM cells consist of closed-flux toroid-shaped elements and intersecting address lines situated above and beneath the elements [J.-G. Zhu, Y. Zheng, and G. A. Prinz, J. Appl. Phys. 87, 6668 (2000)]. Experiments performed on 64-element strings show that the intersecting address lines effectively assist in VMRAM cell switching. With projected density scaling to 400Gbits∕in.2 [J.-G. Zhu, Y. Zheng, and G. A. Prinz, J. Appl. Phys. 87, 6668 (2000)], VMRAM has the potential to compete with both semiconductor memories and mechanical hard disks.
A bronchoscopic brush biopsy study of large airway mucosal pathology in smokers with chronic bronchitis and in healthy nonsmokers (1992)

We investigated the use of bronchial brush biopsies of the bronchial epithelium as a diagnostic tool in common airway diseases. Flexible fibreoptic bronchoscopy was performed on 22 smokers with nonobstructive chronic bronchitis and on 14 healthy nonsmoking individuals. Ten of the smokers had recurrent infectious exacerbations. Cell samples were taken from carinal and subsegmental levels of the bronchial tree with a standard cytological brush, and a differential count was made of the different cell types. Smokers with chronic bronchitis had significantly more goblet cells (mean 20.0, SD 8.6), and less ciliated epithelial cells (mean 74.1, SD 9.4), than the healthy nonsmokers (mean 9.2, SD 3.9 and mean 84.7, SD 6.6, respectively). No such changes were found between the chronic bronchitis groups with or without infectious exacerbations. Thus, bronchial brush biopsies can be used as a complement to standard bronchial biopsies in the investigation of airway diseases other than pulmonary malignancies.
Prevention of Arthritis by Interleukin 10–producing B Cells (2003)

In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-gamma. Transfer of these B cells into DBA/1-TcR-beta-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease. IL-10 is essential for the regulatory function of this subset of B cells, as the B cells population isolated from IL-10 knockout mice failed to mediate this protective function. Furthermore, B cells isolated from arthritogenic splenocytes treated in vitro with anti-IL-10/anti-IL-10R were unable to protect recipient mice from developing arthritis. Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders.
Catalytic Transfer Reduction of Conjugated Alkenes and an Imine Using Polymer‐Supported Formates. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Renewable Alkanes by Aqueous‐Phase Reforming of Biomass‐Derived Oxygenates (2004)

A clean stream of alkanes from renewable biomass resources is obtained through aqueous-phase reforming in a single reactor. Alkanes are produced from biomass-derived sorbitol through a bifunctional pathway (see scheme) that involves the dehydration of sorbitol on acid sites (SiO2/Al2O3) and hydrogenation of intermediates on a metal catalyst under a H2 atmosphere. Hydrogen is produced from sorbitol and water on the metal catalyst in the same reactor. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53050_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
tcaA Inactivation Increases Glycopeptide Resistance in Staphylococcus aureus (2004)

The experimental deletion of the tcaRAB region has been shown to increase teicoplanin resistance in Staphylococcus aureus. By sequential genetic complementation of a tcaRAB mutant, we identified tcaA as the key gene within tcaRAB that is responsible for changes in glycopeptide resistance levels. Northern blot analysis of the tcaRAB region showed that the tcaA gene is expressed only weakly over the growth cycle and is strongly inducible by teicoplanin. Among some clinical isolates tested, glycopeptide-intermediate-resistant (GISA) strains Michigan and SA137/93G were found to have truncated tcaA genes. While the former carries a nucleotide insertion that creates a premature stop codon, the latter was found to harbor an IS256 insertion. Complementation of these two GISA strains with a functional tcaA allele reduced their levels of teicoplanin and vancomycin resistance five- to eightfold and twofold, respectively. The data presented here indicate that inactivation of tcaA contributes to and plays a relevant role in glycopeptide resistance in S. aureus clinical isolates.
Thirty‐six Years in the Clinic without an MMP Inhibitor: What Hath Collagenase Wrought? (1999)

Vertebrate collagenase was discovered in 1962, and within a few short years, several inhibitors had been identified. At one time or another, virtually every major drug company has had an MMP inhibitor program, but in 1999, there is only one such product on the market. With a potential market for lifelong therapy in rheumatoid arthritis, osteoarthritis, periodontal disease, osteoporosis, and cancer, this is certainly puzzling. The problem is that the chemistry appears to have outstripped the biology. In vitro, there are many inhibitors with nanomolar or picomolar efficacy, but in vivo efficacy in animal models does not always follow. There is also a conceptual problem regarding broad-spectrum vs. highly specific inhibitors. Designing human trials to demonstrate MMP inhibition and clinical efficacy is a daunting problem, especially if one seeks to distinguish anti-MMP activity from anti-inflammatory effect. Adult periodontal disease may be the best available human disease model for development of an MMPI.
Polyethylene wear in uncemented acetabular components (1994)

We measured polyethylene wear in 231 porous-coated uncemented acetabular cups. We divided the hips into two groups according to the fixation of the femoral component, by cementing (n = 97) or press-fit (n = 134). Follow-up was from three to five years. The patients in two sub-groups were matched for weight, diagnosis, sex, age and length of follow-up. The linear wear rate of cups articulated with uncemented femoral components (0.22 mm/year) was significantly higher than the wear rate (0.15 mm/year) of cups articulated within cemented femoral components (p < 0.05). These results can be compared with previously reported wear rates of 0.08 mm/year for cemented all-polyethylene cups and 0.11 mm/year for cemented metal-backed cups. The higher wear rates of uncemented arthroplasties could jeopardize the long-term results of this type of hip replacement.
Inhibition of HSV-1 Replication by Laser Diode-Irradiation: Possible Mechanism of Action (2010)

Herpes labialis are the most frequent clinical manifestations of HSV-1 infection. Epithelial cells are able to respond to HSV-1 presence inducing the expression of IL-6, IL-1, TNF-α and IL-8. These proinflammatory cytokines have a function in the acute-phase response mediation, chemotaxis, inflammatory cell activation and antigen-presenting cells. In the human epithelial cell models, it has been demonstrated that, after an early induction of proinflammatory host response, HSV-1 down-modulates the proinflammatory cytokine production through the accumulation of two viral proteins, ICP4 and ICP27, whose transcription is induced by tegument protein VP16. These viral proteins, through the decreasing of stabilizing the mRNAs of proinflammatory genes, delay cytokine production to an extent that allows the virus to replicate. Moreover, viral transactivating proteins, ICP-0 and VP-16 induce IL-10 expression. The conventional treatment of herpes labialis involves the topical and systemic use of antiviral drugs but it is necessary to find new therapies that can act in a selective and non-cytotoxic manner in viral infection. Laser diode therapy has been considered as a non-invasive alternative treatment to the conventional treatment of herpes labialis in pain therapy, in modulation of inflammation and in wound healing. This study aims to report a possible mechanism of action of laser diode irradiation in prevention and reduction of severity of labial manifestations of herpes labialis virus. We investigated, in an in vitro model of epithelial cells HaCat, the laser-effect on HSV-1 replication and we evaluated the modulation of expression of certain proinflammatory cytokines (TNF-α, IL-1β and IL-6), antimicrobial peptide HBD2, chemokine IL-8 and the immunosuppressive cytokine, IL-10. Our results lead us to hypothesize that LD-irradiation acts in the final stage of HSV-1 replication by limiting viral spread from cell to cell and that laser therapy acts also on the host immune response unblocking the suppression of proinflammatory mediators induced by accumulation of progeny virus in infected epithelial cells.
SU‐E‐T‐358: Dosimetric Effects of Beam Angle Arrangements in Lung Proton Therapy (2011)

Purpose: The Inclined Beam Line (IBL) is an innovative partial gantry design which provides two beam angles at 30 and 90 degrees with full flexibility of the patient positioning system of the gantry design. Compared to the full gantry design in proton therapy, the IBL is a simplified design allowing for less equipment maintenance, physics quality assurance, and costs. The purpose of this study was to demonstrate that IBL provides sufficient choice of beam angles and efficient beam delivery to treat most proton lung patients.Methods: Eight lung patients who had proton treatment at our center were selected for this study. We designed three treatment plans for each of the eight patients in supine position, using beam arrangements with (1) full gantry, (2) IBL, and (3) hybrid, i.e., a combination of a gantry plan and an IBL plan with the patients being treated with each plan in alternative days. Xio TPS (CMS, St. Louis, MO) was used to design treatment plans. Results: We have compared the dosimetric differences of the three planning strategies. The PTV D95 was within 1% for all three plans for each patient. On average, the lung V20, V10, and V5 were 3.6%/3.7%, 5.1%/3.7%, and 5.1%/1.6% higher for the IBL plans than that for the gantry/hybrid plans, respectively. Cord max dose, esophagus dose, and heart dose showed similar trends. Among all eight patients, IBL plan was not able to meet cord dose limit for only one patient who was treated for right posterior chest wall. Conclusions: Our results showed that seven out of the eight patients (88%) could be treated with full gantry, IBL, or hybrid plans with sufficient target coverage and reasonable critical structure sparing. Therefore, IBL was a sufficient proton treatment delivery method for most of the lung patients in this study.
Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy (2006)

In myotonic dystrophy (DM), expression of RNA containing expanded CUG or CCUG repeats leads to misregulated alternative splicing of pre-mRNA. The repeat-bearing transcripts accumulate in nuclear foci, together with proteins in the muscleblind family, MBNL1 and MBNL2. In transgenic mice that express expanded CUG repeats, we show that the splicing defect selectively targets a group of exons that share a common temporal pattern of developmental regulation. These exons undergo a synchronized splicing switch between post-natal day 2 and 20 in wild-type mice. During this post-natal interval, MBNL1 protein translocates from a predominantly cytoplasmic to nuclear distribution. In the absence of MBNL1, these physiological splicing transitions do not occur. The splicing defect induced by expanded CUG repeats in mature muscle fibers is closely reproduced by deficiency of MBNL1 but not by deficiency of MBNL2. A parallel situation exists in human DM type 1 and type 2. MBNL1 is depleted from the muscle nucleoplasm because of sequestration in nuclear foci, and the associated splicing defects are remarkably similar to those observed in MBNL1 knockout mice. These results indicate that MBNL1 participates in the post-natal remodeling of skeletal muscle by controlling a key set of developmentally regulated splicing switches. Sequestration of MBNL1, and failure to maintain these splicing transitions, has a pivotal role in the pathogenesis of muscle disease in DM.