gebhart/patrepeval huggingface dataset:
Effects of Geometry on Slot–Jet Film Cooling Performance (1996)

The physics of the film cooling process for shaped, inclined slot–jets with realistic slot–length–to–width ratios (L/s) is studied for a range of blowing ratio (M) and density ratio (DR) parameters typical of gas turbine operations. The effect of inlet and exit shaping of the slot–jet on both flow and thermal field characteristics is isolated, and the dominant mechanisms responsible for differences in these characteristics are documented. A previously documented computational methodology was applied for the study of four distinct configurations: (1) slot with straight edges and sharp comers (reference case); (2) slot with shaped inlet region; (3) slot with shaped exit region; and (4) slot with both shaped inlet and exit regions. Detailed field results as well as surface phenomena involving adiabatic film effectiveness (η) and heat transfer coefficient (h) are presented. It is demonstrated that both η and h results are vital in the proper assessment of film cooling performance. The key parameters M and DR were varied from 1.0 to 2.0 and 1.5 to 2.0, respectively, to show their influence. Simulations were repeated for slot length–to–width ratio (L/s) of 3.0 and 4.5 in order to explain the effects of this important parameter. The computational simulations showed exceptionally strong internal consistency. Moreover, the ability of using a state–of–the–art computational methodology to sort the relative performance of different slot–jet film cooling configurations was clearly established.
Are we ready for autonomous driving? The KITTI vision benchmark suite (2012)

Today, visual recognition systems are still rarely employed in robotics applications. Perhaps one of the main reasons for this is the lack of demanding benchmarks that mimic such scenarios. In this paper, we take advantage of our autonomous driving platform to develop novel challenging benchmarks for the tasks of stereo, optical flow, visual odometry/SLAM and 3D object detection. Our recording platform is equipped with four high resolution video cameras, a Velodyne laser scanner and a state-of-the-art localization system. Our benchmarks comprise 389 stereo and optical flow image pairs, stereo visual odometry sequences of 39.2 km length, and more than 200k 3D object annotations captured in cluttered scenarios (up to 15 cars and 30 pedestrians are visible per image). Results from state-of-the-art algorithms reveal that methods ranking high on established datasets such as Middlebury perform below average when being moved outside the laboratory to the real world. Our goal is to reduce this bias by providing challenging benchmarks with novel difficulties to the computer vision community. Our benchmarks are available online at: www.cvlibs.net/datasets/kitti.
Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro. (1995)

The requirements for generating CD8+ CTLs against the mastocytoma P815 were first defined by using an allogeneic mixed lymphocyte tumor culture (MLTC). Both the expansion of effector lymphocytes and the acquisition of lytic activity were dependent on the presence of accessory cells, but not CD4+ lymphocytes. Several factors were examined for their ability to replace accessory cell function. Expression of B7-1 by P815 was sufficient to induce IL-2 production by CD8+ cells, but substantial proliferation was achieved only if IL-6 was provided as well. Although IL-12 had little effect on the net proliferation of developing effector cells, it increased specific lytic activity 10-fold, acted synergistically with B7-1 in induction of IFN-gamma production during primary stimulation, and resulted in a shift toward a Th1 cytokine profile following secondary stimulation. These costimulatory factors were then studied in a primary syngeneic MLTC by using splenocytes from nonimmunized DBA/2 mice, an approach that had never before succeeded in generating specific CTLs. The combination of B7-1, IL-6, and IL-12 was sufficient to induce P815-specific CTL activity after a 5-day MLTC, which was expanded optimally following secondary stimulation in the presence of B7-1, IL-2, and IL-7. The irrelevant syngeneic tumor L1210, constructed to express B7-1 and the P815-derived tumor Ag gene P1A, also generated CTLs that lysed the parental P815. The combination of B7-1, IL-6, and IL-12 should be useful in the derivation of other tumor-specific CTLs in vitro, and may constitute the optimal stimuli for rapid proliferation and differentiation of helper-independent, tumor-specific CTLs in vivo.
Physical therapy modalities for wound management. (1996)

As part of a multidisciplinary team approach to the management of chronic wounds, physical therapists can add certain physical modalities to the care plan. Whirlpool, electrical stimulation, ultrasound, low-energy laser and compression therapy are physical therapy modalities that have been used to enhance wound healing. All of these modalities are used as adjunct treatments that, when appropriate, may help shorten the length of treatment and reduce patient suffering. Because the efficacy of some of these modalities remains to be established in controlled clinical trials, conventional wound care continues to be an important part of the team approach.
A Simple One-Pot Preparation of N,N’-Unsymmetrical Ureas from N-Boc Protected Primary Anilines and Amines (1996)

N-Boc protected primary amines and anilines can be converted efficiently into N,N'-unsymmetrically substituted ureas by sequential deprotonation and condensation with amines at 65°C.
New concepts and materials in microvascular grafting: Prosthetic graft endothelial cell seeding and gene therapy (1998)

Microsurgical free tissue transfer is currently associated with very high success rates and few complications. While interposition vein grafting is clearly an important adjunct to the microsurgeon's armamentarium, it has been associated with higher free flap/replantation failures and complication rates. With appropriate flap planning and surgical techniques, the need for interposition vein grafting should be quite infrequent and hopefully avoided if at all possible. Nevertheless, when necessary, the vein graft remains the gold standard, with virtually all alternative interposition grafts demonstrating lower patency rates. One of the more promising areas of research is the concept of genetic manipulation of the endothelial cell via molecular biological techniques. It is likely that in the near future this may become a clinical reality, not only improving the patency of microsurgical anastomoses and interposition vein grafts, but quite possibly altering the target organ functionally as well.
International debt and the developing countries (1985)

The conference papers contained in this book address the problem of international debt. They have been organized into four sections. In the first, microeconomic theories of international borrowing and lending are developed and applied to the current situation. Sovereign risk is an important feature in these analyses. The second section deals in greater depth with bank behavior, the structure of financial markets, and recent suggestions for structural reform of these markets. Section III contains an econometric analysis of the precursors of debt repayment problems and asks whether they can be predicted in advance with the use of available macroeconomic information. Case studies of Argentina, Brazil, Chile, Korea, and Mexico are studied in the final section to determine how and why they experienced debt-servicing problems in 1982-1984. The roles of domestic macroeconomic policies as well as of external shocks are carefully considered.
A Novel Series of Amphiphilic Imidazolinium Compounds for in Vitro and in Vivo Gene Delivery (1995)

We have developed three catioinic amphiphiles based on the structure 1-[2-(acyloxy)ethyl]-2-alkyl(alkenyl)-3-(2-hydroxyethyl)imidazolinium chloride. Although these three compounds differ only in the structure of the hydrophobic acyl chains, they differ greatly in their ability to mediate in vivo and in vitro gene delivery. Moreover, in vitro efficiency is not predictive of in vivo efficiency. The myristoyl form is the most effective compound in vitro, and the oleoyl form is the most effective compound in vivo. The compounds readily form suspensions in aqueous media, both in the pure form and as mixtures with either cholesterol or dioleoylphosphatidylethanolamine. These suspensions can be sonicated to produce smaller particles. Particle size, electron microscopy, and the ability to capture glucose suggest that these lipids form liposomes on suspension in aqueous media. When mixed with plasmid DNA, the lipid particles appear to fuse and form larger particles. Fusion is maximal at the critical DNA:lipid ratio where extensive aggregation and precipitation are observed. Therefore, these compounds behave similarly to other cationic liposome-forming lipids upon interaction with DNA.
The Current Role of Circulating Tumor Cells in the Diagnosis and Management of Bone Metastases in Advanced Prostate Cancer (2012)

Prostate-specific antigen (PSA) has been used for over two decades as a serum marker for adenocarcinoma of the prostate. Although PSA screening remains an important part of disease screening and monitoring in early prostate cancer (PC), its utility in monitoring disease progression in advanced PC is undetermined. Furthermore, the role of PSA monitoring in the management of patients with PC and bone metastases appears limited. The purpose of this review is to evaluate the role of circulating tumor cells (CTCs) as potential novel biomarkers in advanced PC. We present a review of CTC testing and the clinical data supporting the prognostic potential of CTCs in this setting. We propose that combination of CTCs and PSA velocity or doubling-time assessments may offer insights into the prognosis and management of advanced PC.
DRAGON, a Bone Morphogenetic Protein Co-receptor (2005)

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)beta superfamily of ligands that regulate many crucial aspects of embryonic development and organogenesis. Unlike other TGFbeta ligands, co-receptors for BMP ligands have not been described. Here we show that DRAGON, a glycosylphosphatidylinositol-anchored member of the repulsive guidance molecule family, which is expressed early in the developing nervous system, enhances BMP but not TGFbeta signaling. DRAGON binds directly to BMP2 and BMP4 but not to BMP7 or other TGFbeta ligands. The enhancing action of DRAGON on BMP signaling is also reduced by administration of Noggin, a soluble BMP antagonist, indicating that the action of DRAGON is ligand-dependent. DRAGON associates directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, and its signaling is reduced by dominant negative Smad1 and ALK3 or -6 receptors. In the Xenopus embryo, DRAGON both reduces the threshold of the ability of Smad1 to induce mesodermal and endodermal markers and alters neuronal and neural crest patterning. The direct interaction of DRAGON with BMP ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling.
Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C. (1996)

This data suggests that both omeprazole and lansoprazole increase fasting serum gastrin and serum pepsinogen A and C levels, but have no effects on postprandial serum gastrin and pepsinogens levels.
The Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family (1992)

A regulatory gene, cynR, was found to be located next to the cyn operon but transcribed in the opposite direction. cynR encodes a positive regulatory protein that controls the cyn operon as well as its own synthesis. Positive regulation of the cyn operon requires cyanate and the cynR protein, but the negative autoregulation of the cynR gene appears to be independent of cyanate. The predicted amino acid sequence of the cynR protein derived from the DNA sequence was found to have significant homology to the predicted amino acid sequence of the lysR family of regulatory proteins.
Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models (2008)

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β-amyloid precursor protein (APP) after β- and γ-secretase cleavage. The molecular mechanism underlying the pathogenesis of AD is not yet well defined, and there has been no effective treatment for AD. Valproic acid (VPA) is one of the most widely used anticonvulsant and mood-stabilizing agents for treating epilepsy and bipolar disorder. We found that VPA decreased Aβ production by inhibiting GSK-3β–mediated γ-secretase cleavage of APP both in vitro and in vivo. VPA treatment significantly reduced neuritic plaque formation and improved memory deficits in transgenic AD model mice. We also found that early application of VPA was important for alleviating memory deficits of AD model mice. Our study suggests that VPA may be beneficial in the prevention and treatment of AD.
Non-Noble Electrocatalysts for O2 Reduction:  How Does Heat Treatment Affect Their Activity and Structure? Part II. Structural Changes Observed by Electron Microscopy, Raman, and Mass Spectroscopy (2007)

In part I of this paper, a model was proposed to (i) describe the gasification of a spherical carbon black particle by ammonia at high temperature and (ii) explain the activity for the O2 electroreduction of catalysts based on Fe and carbon heat-treated in NH3. In this second part, such catalysts, heat-treated for various times in ammonia, are characterized by electron microscopy, Raman spectroscopy, and time-of-flight secondary ion mass spectrometry (ToF-SIMS). Electron microscopy shows an average particle diameter of 38 nm for the pristine furnace black, decreasing to 28 nm after the carbon powder loses 90% of its mass. This agrees with model prediction. Raman spectroscopy shows that the experimental width at half-maximum of both the graphitic peak (∼1595−1600 cm-1) and the disorder and graphitic-edge peak (∼1345−1355 cm-1) constantly decreases with increasing weight loss. It is found that the width at half-maximum of these peaks correlates with the fraction of disordered carbon phase calculated by the model. Last, changes of the ToF-SIMS total and Fe+ signals upon gasification of the carbon black also support the model.
Activation of the Cardiac Interleukin-6 System in Advanced Heart Failure (2001)

In advanced heart failure, cardiac IL6/IL6R mRNA expression is increased and may play a role in the pathophysiology of advanced heart failure.
Coding of subregions for content-based scalable video (1997)

We propose a scheme for coding subregions in video scenes to provide content-based scalable video. For each region, a special color is used to represent the nonobject area, and the resulting frames are coded using conventional video coding algorithms. At the decoder, the region shape is recovered based on chroma keying, and hence, content-based manipulations are made possible. A number of techniques that eliminate boundary artifacts common to region-based coding are presented. In this scheme, no explicit shape coding is needed, and advantages of existing coding algorithms are retained. This scheme was submitted to ISO MPEG-4 and performed very well in the subjective tests.
Diblock Thin Films with Densely Hexagonally Packed Nanochannels (1998)

Films, 2μm thick, with hexagonally packed and uniformly sized nanochannels with a diameter of ∼17 nm and at a density of ∼5 × 1010 cm–2 were prepared. These channels were partially filled with poly(acrylic acid) (PAA) and the structural change of PAA chains with variations in pH, ionic strength, and ion type caused water permeability to change by several orders of magnitude. These membranes with “chemical valves” should be useful in controlled drug release or chemical sensing. In cyclopentane, the PAA chains probably collapse onto the channel walls and the channel centers should open up. The channels allowed the separation of species according to their difference in size and this property should be useful for future studies of polymer chain reptation through the nanochannels.
A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals (1999)

A HIDAC-PET camera consisting essentially of 5 million 0.5 mm gas avalanching detectors has been constructed for small-animal imaging. The particular HIDAC advantage-a high 3D spatial resolution-has been improved to 0.95 mm fwhm and to 0.7 mm fwhm when reconstructing with 3D-OSEM methods incorporating resolution recovery. A depth-of-interaction resolution of 2.5 mm is implicit, due to the laminar construction. Scatter-corrected sensitivity, at 8.9 cps/kBq (i.e. 0.9%) from a central point source, or 7.2cps/kBq (543cps/kBq/cm/sup 3/) from a distributed (40 mm diameter, 60 mm long) source is now much higher than previous, and other, work. A field-of-view of 100 mm (adjustable to 200 mm) diameter by 210 mm axially permits whole-body imaging of small animals, containing typically 4 MBqs of activity, at 40 kcps of which 16% are random coincidences, with a typical scatter fraction of 44%. Throughout the field-of-view there are no positional distortions and relative quantitation is uniform to /spl plusmn/3.5%, but some variation of spatial resolution is found. The performance demonstrates that HIDAC technology is quite appropriate for small-animal PET cameras.
Purification of the human placental α2‐macroglobulin receptor (1989)

The alpha 2-macroglobulin receptor was solubilized from human placental membranes, purified and characterized. Affinity cross-linking of labelled ligand to intact membranes showed a receptor size compatible with 400-500 kDa. The membranes were solubilized in 3-[(3-cholamidopropyl)dimethylammonio]propane sulfonate (CHAPS) and affinity chromatography was performed using Sepharose-immobilized alpha 2-macroglobulin-methylamine with elution in buffer containing 2 mM EDTA, pH 6.0. SDS-PAGE of the resulting receptor preparation showed a predominant approx. 440 kDa band (reducing conditions) and some minor accompanying proteins of 70-90 kDa and 40 kDa. The yield was 400-800 micrograms receptor preparation per placenta. The receptor preparation immobilized on nitrocellulose bound the alpha 2-macroglobulin-trypsin complex with a dissociation constant of about 400 pM. 125I-iodinated receptor preparation bound almost quantitatively to Sepharose-immobilized alpha 2-macroglobulin-methylamine in the presence of CHAPS alone, and bound 70-80% in the presence of 0.2% SDS. The labelled proteins were separated in the presence of 0.2% SDS by gel filtration or SDS-PAGE (unboiled samples). The 440 kDa protein accounted for the major part of the binding, although some approx. 80 kDa proteins, perhaps proteolytic degradation products, also showed binding activity.
Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways (2004)

Pulmonary epithelial cells are continuously exposed to microbial challenges as a result of breathing. It is recognized that immune myeloid cells express Toll-like receptors (TLRs), which play a major role in detecting microbes and initiating innate immune responses. In contrast, little is known concerning the expression of TLR in pulmonary epithelial cells per se, their distribution within the cell, their function, and the signaling pathways involved. In this work, we demonstrated by reverse transcription-PCR and/or immunoblot that TLR4 and the accessory molecule MD-2 are constitutively expressed in distinct human alveolar and bronchial epithelial cells. We further characterized by flow cytometry, biotinylation/precipitation, and confocal microscopy the intracellular localization of TLR4 in these cells. Despite this intracellular compartmentalization of TLR4, pulmonary epithelial cells were responsive to the TLR4 activator lipopolysaccharide (LPS), a potent Gram-negative bacteria-associated molecular pattern. Using respiratory epithelial cells isolated from TLR4 knock-out and wild type mice, we demonstrated that TLR4 is the actual activating receptor for LPS in these cells. Furthermore we showed that this cell response to LPS involves a signaling complex including the kinases interleukin-1 receptor-associated kinase (IRAK), p38, Jnk, and ERK1/2. Moreover, using vectors expressing dominant-negative forms of MyD88 and TRAF6, we established that LPS-induced activation of respiratory epithelial cells is largely dependent on TLR4 signaling intermediates. Altogether these data demonstrate that TLR4 is a key element in the response of pulmonary epithelial cells to molecules derived from Gram-negative bacteria. The intracellular localization of TLR4 in lung epithelia is expected to play an important role in the prevention of the development of chronic inflammatory disease.
Two Distinct Notch1 Mutant Alleles Are Involved in the Induction of T-Cell Leukemia in c-myc Transgenic Mice (2000)

We have previously characterized a large panel of provirus insertion Notch1 mutant alleles and their products arising in thymomas of MMTV(D)/myc transgenic mice. Here, we show that these Notch1 mutations represent two clearly distinct classes. In the first class (type I), proviral integrations were clustered just upstream of sequences encoding the transmembrane domain. Type I Notch1 alleles produced two types of mutant Notch1 RNA, one of which encoded the entire Notch1 cytoplasmic domain [N(IC)] and the other of which encoded a soluble ectodomain [N(EC)(Mut)] which, in contrast to the processed wild-type ectodomain [N(EC)(WT)], did not reside at the cell surface and became secreted in a temperature-dependent manner. A second, novel class of mutant Notch1 allele (type II) encoded a Notch1 receptor with the C-terminal PEST motif deleted (DeltaCT). The type II Notch1(DeltaCT) protein was expressed as a normally processed receptor [N(EC)(WT) and N(IC)(DeltaCT)] at the cell surface, and its ectodomain was found to be shed into the extracellular medium in a temperature- and calcium-dependent manner. These data suggest that both type I and type II mutations generate two structurally distinct Notch1 N(EC) and N(IC) proteins that may participate in tumor formation, in collaboration with the c-myc oncogene, through distinct mechanisms. Constitutive type I N(IC) and type II N(IC)(DeltaCT) expression may enhance Notch1 intracellular signaling, while secreted or shed type I N(EC)(Mut) and type II N(EC) proteins may differentially interact in an autocrine or paracrine fashion with ligands of Notch1 and affect their signaling.
Bayesian methods for discrete event simulation (2004)

Bayesian methods are now used in a variety of ways in discrete-event simulation. Applications include input modeling, response surface modeling, uncertainty analysis, and experimental designs for field data collection, selection procedures, and response surface estimation. This paper reviews some fundamental concepts of subjective probability and Bayesian statistics that have led to results in simulation applications.