gebhart/patrepeval huggingface dataset:
Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis (2003)

Indian hedgehog (IHH) and its receptors patched (PTC) and smoothened (SMO) belong to the hedgehog family of signaling molecules, which are essential for a variety of patterning events during mammalian tIssue development. IHH plays a role in pancreas organogenesis and differentiation, as well as in the regulation of insulin production. In the present study, the expression of IHH and its receptors was analyzed in normal human pancreatic and chronic pancreatitis (CP) tIssues using Northern blotting, immunohistochemistry and Western blotting, and was correlated with clinicopathological parameters. In addition, the effects of inhibition and stimulation of the hedgehog signaling pathway on cell growth were determined in TAKA-1 normal pancreatic ductal cells. IHH mRNA was expressed in the normal human pancreas and CP tIssues, with slightly higher expression levels in CP. Using immunohistochemistry, IHH and its receptors were localized mainly in the islet cells of the normal pancreas. In CP, IHH and its receptors were present in the cells forming tubular complexes and in the islets with a different signal pattern compared with the islets in the normal pancreas. Correlation between diabetic and non-diabetic CP patients revealed no significant difference in IHH, SMO, or PTC immunoreactivity. Inhibition of hedgehog signaling in TAKA-1 pancreatic ductal cells using cyclopamine significantly reduced their growth through cell cycle arrest, while stimulation of the IHH pathway enhanced the growth of these cells. In conclusion, IHH and its receptors are expressed in the normal human pancreas and in CP, yet with a different distribution and cellular localization. IHH signaling may be involved in the pathogenesis of CP, i.e. in the formation and proliferation of tubular complexes and in islet cell dysfunction.
Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma (2016)

High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
Study on the Structure‐Activity Relationship of New Anti‐HIV Nucleoside Derivatives Based on the Support Vector Machine Method (2006)

Abstract Support Vector Machine (SVM) was used for the classification of the activity of the new anti‐HIV nucleosides derivatives for a large and diverse data set using the twelve descriptors that were calculated from the molecular structure alone. The molecular descriptors were selected by the stepwise Linear Discriminant Analysis (LDA) method implemented in SPSS. The correlation between all the descriptors was lower than 0.85. At the same time, in order to build a nonlinear model to classify the new anti‐HIV drugs according to their activities, the data set was divided into two subgroups: the training set and the testing set. The nonlinear model gives satisfactory results, which can classify correctly 91.5% of the compounds in the training set and 91.4% of the compounds in the testing set. In addition, this paper provides a new and effective method for classifying the new anti‐HIV nucleoside derivatives from their structures according to their activities and gives some insight into structural features related to the activity of the drugs.
Repeat Surgery After Disc Excision (1978)

Sixty patients requiring repeat surgery after lumbar disc excision are reviewed. Thirty-one had had their initial surgery performed by the authors and represent a 5.9% frequency of repeat surgery after initial laminectomy for sciatica. Of the 60 patients, 49 suffered recurrent radicular pain, 20 suffered from back pain, and 8 had other problems (infection, extradural cysts, etc.). In patients with recurrent sciatica, perineural fibrosis and recurrent herniation were the most common problems; those patients with the latter pathologic condition responded most favorably to repeat surgery. Of 520 patients who had undergone disc excision, only 9 required secondary fusion.
Luminescent greenhouse collector for solar radiation (1976)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text W. H. Weber and John Lambe, "Luminescent greenhouse collector for solar radiation," Appl. Opt. 15, 2299-2300 (1976) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma (2003)

Immunotherapy (IT) has become an accepted therapeutic modality. We previously reported that intracellular hyperthermia (IH) using magnetic nanoparticles induces antitumor immunity. We undertook these studies in order to study the combined effects of IT and IH on melanoma. Magnetite cationic liposomes (MCLs) have a positive surface charge and generate heat in an alternating magnetic field (AMF) due to hysteresis loss. MCLs were injected into a B16 melanoma nodule in C57BL/6 mice, which were subjected to AMF for 30 min. The temperature at the tumor reached 43 degrees C and was maintained by controlling the magnetic field intensity. At 24 h after IH, interleukin-2 (IL-2) or granulocyte macrophage-colony stimulating factor (GM-CSF) was injected directly into the melanoma. Mice were divided into six groups: group I (control), group II (IH), group III (IL-2), group IV (GM-CSF), group V (IH + IL-2), and group VI (IH + GM-CSF). Complete regression of tumors was observed in mice of groups V and VI (75% (6/8) and 40% (4/10) of the mice, respectively), while no tumor regression was observed in mice of the other groups. This study supports the combined use of IT and IH using MCLs in patients with advanced malignancies.
The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity. (1988)

The gene for copper, zinc-superoxide dismutase (Cu,Zn-SOD; EC 1.15.1.1) from the yeast Saccharomyces cerevisiae has been cloned, sequenced, and shown to have physiological activity. The gene was isolated from a lambda gt11 library by using a long, unique deoxyoligonucleotide probe. The probe sequence was deduced from the known amino acid sequence by using a computer-generated yeast codon preference table. The sequence of the coding and flanking regions is reported. The cloned gene was expressed and shown to be active in vivo. A 3.2-kilobase fragment containing the coding region and 160 upstream bases, subcloned in a yeast/Escherichia coli shuttle vector, was used to transform a yeast strain lacking Cu,Zn-SOD activity. The presence of the Cu,Zn-SOD gene-containing plasmid corrected the characteristic dioxygen sensitivity of this strain. Electrophoretic transfer blots with antibody to yeast Cu,Zn-SOD showed the presence of the protein in transformants and wild-type yeast but not in the mutant. The role of Cu,Zn-SOD in defense against dioxygen toxicity is discussed in the light of these findings.
Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation. (1996)

We have related experimentally induced post-cardiac transplant coronary arteriopathy to increased elastolytic activity, IL-1beta, fibronectin-mediated inflammatory and smooth muscle cell (SMC) migration, and SMC proliferation. Since our in vitro studies show that a serine elastase releases SMC mitogens and facilitates IL-lbeta induction of fibronectin, we hypothesized that administration in vivo of the specific serine elastase inhibitor, elafin, would decrease the post-cardiac transplant coronary arteriopathy. Cholesterol-fed rabbits underwent a heterotopic cardiac transplant without immunosuppression and received elafin (1.79 mg/kg per d continuous infusion after a 9 mg bolus, n = 6) or vehicle (n = 6). 1 wk later, hearts were harvested for morphometric, immunohistochemical, and biochemical analyses. A > 70% decrease in the total number of coronary arteries with intimal thickening in elafin-treated compared to control donor hearts (P < 0.002) was associated with reduced vascular elastolytic activity judged by fewer breaks in the internal elastic lamina (P < 0.03), less accumulation of immunoreactive fibronectin (P < 0.02), and reduced cell proliferation quantified by proliferating cell nuclear antigen (P < 0.0001). Despite myocardial lymphocytic infiltration, wet weight of elafin-treated donor hearts was reduced by 50% compared to untreated controls (P < 0.002) and associated with relative preservation of myocyte integrity, instead of extensive myocardial necrosis (P < 0.004). This protective effect correlated with decreased myocardial elastolytic activity (P < 0.0001) and inflammatory cell proliferation (P < 0.0001) and with an elafin-inhibitable elastase in lymphocytes. Serine elastase activity thus appears an important therapeutic target for post-cardiac transplant coronary arteriopathy and myocardial necrosis induced by rejection.
DNA polymerases, deoxyribonucleases, and recombination during meiosis in Saccharomyces cerevisiae. (1984)

We utilized strains of Saccharomyces cerevisiae that exhibit high efficiency of synchrony of meiosis to examine several aspects of meiosis including sporulation, recombination, DNA synthesis, DNA polymerase I and II, and Mg2+-dependent alkaline DNases. The kinetics of commitment to intragenic recombination and sporulation are similar. The synthesis of DNA, as measured directly with diphenylamine, appears to precede the commitment to recombination. Both DNA polymerase I and II activities and total DNA-synthesizing activity in crude extracts increase two- to threefold before the beginning of meiotic DNA synthesis. Increases of 10- to 20-fold over mitotic levels are found for Mg2+-dependent alkaline DNase activity in crude extracts before and during the commitment to meiotic intragenic recombination. Of particular interest is the comparable increase in a nuclease under the control of the RAD52 gene; this enzyme has been identified by the use of antibody raised against a similar enzyme from Neurospora crassa. Since the RAD52 gene is essential for meiotic recombination, the nuclease is implicated in the high levels of recombination observed during meiosis. The effects observed in this report are meiosis specific since they are not observed in an alpha alpha strain.
First Dual Aromatase-Steroid Sulfatase Inhibitors (2003)

Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is an important additional source of tumor estrogen, and blockade of both enzymes should provide a more effective endocrine therapy. Sulfamoylated derivatives of the aromatase inhibitor YM511 inhibited sulfatase and aromatase in JEG-3 cells with respective IC(50) values of 20-227 and 0.82-100 nM (cf. letrozole, 0.89 nM). One dual inhibitor was potent against both enzymes in vivo, validating the concept.
Antitumor Agents, 82. Cytotoxic Sapogenols from Aesculus hippocastanum (1986)

Two cytotoxic sapogenols, the new hippocaesculin (1) and the known barringtogenol-C 21-angelate (2), were isolated from the acid hydrolysis product of a crude saponin fraction that was obtained from the fruits of Aesculus hippocastanum. The structures of 1 and 2 were determined from their chemical transformations and spectral data. Compound 1 is either 21-O-angeloyl, 22-O-tigloyl R1-barrigenol, or 21-O-tigloyl, 22-O-angeloyl R1-barrigenol.
LLR-based symbol selective transmission with a near-optimal threshold to minimize BEP for demodulation-forward relay systems (2010)

Error propagation in the source-relay link limits the performance of demodulation-forward (MF) relay systems. In order to solve this problem and efficiently exploit the relay, we propose log likelihood ratio (LLR)-based symbol selective transmission with a near-optimum threshold to minimize the bit error probability (BEP). In the proposed scheme, the source information is forwarded by the relay only if it is likely to be detected correctly, as determined by a comparison of the LLR with the near-optimum threshold. To derive the near-optimum threshold, the BEP of the proposed scheme is analyzed in the case of binary phase shift keying (BPSK) signals. Simulation results confirm the accuracy of the analysis and prove that the proposed scheme efficiently mitigates error propagation.
Electron-transfer between iron, ruthenium, and osmium complexes containing 2,2'-bipyridyl, 1,10-phenanthroline, or their derivatives. Effects of electrolytes on rates (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron-transfer between iron, ruthenium, and osmium complexes containing 2,2'-bipyridyl, 1,10-phenanthroline, or their derivatives. Effects of electrolytes on ratesNelson D. Stalnaker, John C. Solenberger, and Arthur C. WahlCite this: J. Phys. Chem. 1977, 81, 7, 601–604Publication Date (Print):April 1, 1977Publication History Published online1 May 2002Published inissue 1 April 1977https://pubs.acs.org/doi/10.1021/j100522a003https://doi.org/10.1021/j100522a003research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy (2007)

Breast calcifications can be found in both benign and malignant lesions, and the composition of these calcifications can indicate the possible disease state. As current practices such as mammography and histopathology examine the morphology of the specimen, they cannot reliably distinguish between the two types of calcification, which frequently are the only mammographic features that indicate the presence of a cancerous lesion. Raman spectroscopy is an optical technique capable of obtaining biochemical information of a sample in situ. We demonstrate for the first time the noninvasive recovery of Raman spectra of calcified materials buried within a chicken breast tissue slab 16 mm thick, achieved using transmission Raman spectroscopy. The spectra of both calcium hydroxyapatite (HAP) and calcium oxalate monohydrate (COM) are obtained and chemically identified. The experimental geometry and gross insensitivity of the Raman signal to the depth of the calcified lesion makes the concept potentially well suited for probing human female breasts, in conjunction with existing mammography or ultrasound, to provide complementary data in the early diagnosis of breast cancer.
Cooperative upconversion in erbium-implanted soda-lime silicate glass optical waveguides (1995)

Soda-lime silicate glass has been locally doped with 0.2-at. % erbium by 3.0- and 5.0-MeV ion implantation. Single-mode fiber-compatible optical waveguides were then fabricated by use of Na+ ↔ K+ ion exchange. Characteristic photoluminescence (PL) of Er3+ centered at 1.54 μm is observed on excitation at 1.48 μm. For low pump intensity the PL decay is nearly single exponential with a lifetime of 7.2 ms. At high intensity it becomes nonexponential as a result of cooperative upconversion, an interaction between excited Er ions. Self-consistent modeling of the PL intensity and decay data yields an upconversion coefficient of 3.2 ± 0.8 × 10−24 m3/s. The effect of upconversion on optical gain is shown and discussed. An extrapolation of measured optical gain shows that 1 dB/cm of net gain is possible in the present Er-implanted soda-lime glass.
Intelligence, Surveillance, and Reconnaissance fusion for coalition operations (2008)

W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the US Government, the UK Ministry of Defence or the UK Government. The US and UK Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. This paper includes British Crown copyright material. Abstract – Coalition operations rely on the fusion, sharing and dissemination of information for a network of disparate Intelligence, Surveillance and Reconnaissance (ISR) assets such as sensors, sensing platforms, human intelligence, data fusion and networking elements. One prominent aspect of this research is the design of policy-aware fusion, that is, fusion that takes policy related to security, resource control, command-and-control, etc. into account. Processes are described for development of fusion algorithms and policy protocols that will enable rapid assembly/dynamic control of ISR assets and associated policy agreements that govern the sharing and dissemination of information to support multiple concurrent coalition missions.
Hybrid electronic fiber optic wavelength-multiplexed system for true time delay steering of phased array antennas (1992)

A hybrid electronic fiber optic true time-delay steering architecture is presented which retains the highly hardware compressive property of an earlier all-optical approach and introduces the economical advantages of electronics at every level possible without compromising overall performance. The architecture is particularly suited to large arrays where maximum advantage can be taken of the hardware compression. A detailed design based on this architecture is described for steering a linear, 16-element, <i>L</i>-band (0.7- to 1.4-GHz) array in transmit mode over a scan angle of ±20 deg with a delay resolution of 6 bits (0.63 deg). An analysis of the expected performance of the design is given together with progress toward the fabrication of the prototype system, which includes the first iteration electronic binary delay line subsystem and a single-segment, high-fidelity, directly modulated DFB laser diode fiber optic link. The experimental data from these modules is in agreement with the performance predicted from the analysis.
EFFECT OF ANISOTROPY IN PERMEABILITY AND EFFECTIVE THERMAL CONDUCTIVITY ON THERMAL PERFORMANCE OF AN ALUMINUM FOAM HEAT SINK (2001)

(2001). EFFECT OF ANISOTROPY IN PERMEABILITY AND EFFECTIVE THERMAL CONDUCTIVITY ON THERMAL PERFORMANCE OF AN ALUMINUM FOAM HEAT SINK. Numerical Heat Transfer, Part A: Applications: Vol. 40, No. 1, pp. 21-36.
A New Voltammetric Stripping Method Applied to the Determination of the Brightener Concentration in Copper Pyrophosphate Plating Baths (1978)

A new voltammetric stripping method for determining the concentration of brightening or leveling additives in plating baths is described. The method is based on the effect that such additives exert on the rate of metal electrodeposition. To determine the latter, the potential of an inert rotating electrode is cycled in the bath, so that a small amount of metal is alternately deposited on the surface and then stripped off, i.e., anodically dissolved. The charge required to strip the copper is related to the deposition rate and, thus, to the concentration of additive in the plating bath. Errors caused by changes in the electrode surface or bath composition are mitigated by using the internal standard provided by the static electrode. Results are reported for the determination of both 2,5‐dimercapto‐1,3,4‐thiadiazole and proprietary brightener PY61‐H in copper pyrophosphate baths, for which a precision of about 0.1 ppm (0.1 ml/liter of PY61‐H) was attained in the concentration range from 0.0 to 2.5 ppm (0.0–2.0 ml/liter). The effect of bath contamination is also considered and a model is proposed to explain the effectiveness of dimercaptothiadiazoles as leveling agents.
Activated Prothrombin Concentrate for Patients with Factor VIII Inhibitors (1974)

Abstract Activated prothrombin concentrate, a complex containing prothrombin, factors VII, IX, X, and XI, was used successfully for the treatment of hemorrhagic episodes in eight patients with factor VIII inhibitors. Six had hemophilia A, and two were women with acquired inhibitors. Partial thromboplastin times decreased immediately after infusion of the complex, and remained low for as long as 24 hours. Prothrombin times decreased also, whereas factor X rose 200 to 300 per cent, and factor VII levels increased by as much as 2000 per cent. Although thrombotic complications can occur after infusions of regular prothrombin complex preparations, none developed with the activated concentrate. Fibrin split products were found in two patients in titers of 1:5 and 1:40. This complex appears to offer effective control of severe hemorrhage in patients with factor VIII inhibitors. (N Engl J Med 291:164–167, 1974)
Review of the Effectiveness of Capsaicin for Painful Cutaneous Disorders and Neural Dysfunction (1998)

Capsaicin is effective for psoriasis, pruritus, and cluster headache; it is often helpful for the itching and pain of postmastectomy pain syndrome, oral mucositis, cutaneous allergy, loin pain/hematuria syndrome, neck pain, amputation stump pain, and skin tumor; and it may be beneficial for neural dysfunction (detrusor hyperreflexia, reflex sympathetic dystrophy, and rhinopathy). A universal problem for many of the studies analyzed was the absence of a "burning placebo" such as camphor.
Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na + Channel Blockade and to Increases in Heart Rate (1995)

This is the first study to demonstrate differential responses of LQTS patients to interventions targeted to their specific genetic defect. These findings also suggest that LQT3 patients may be more likely to benefit from Na+ channel blockers and from cardiac pacing because they would be at higher risk of arrhythmia at slow heart rates. Conversely, LQT2 patients may be at higher risk to develop syncope under stressful conditions because of the combined arrhythmogenic effect of catecholamines with the insufficient adaptation of their QT interval when heart rate increases.
EFFECT OF CLIMATIC CONDITIONS ON DIFFUSIBLE HYDROGEN CONTENT IN WELD METAL (1991)

A method for predicting atmospheric influence on diffusible hydrogen for climates worldwide is presented.