gebhart/patrepeval huggingface dataset:
Studies of Inkjet Printing Technology with Focus on Electronic Materials (2010)

Printed electronics (PE) is based on printing thin- and thick-film structures on cost-sensitive flexible substrates, such as paper-like, plastic, and on rigid substrates using a novel approach to manufacturing electronics which also enables two- or threedimensional printing. Unlike conventional electronic manufacturing, i.e., subtractive photolithography techniques, PE is an additive processing method, whereby the functional material is deposited in a controlled manner to print the desired pattern without wasting the material. Electronics can be printed using several methods, e.g., screen printing, flexography, gravure printing, offset lithography, nano-imprint, and inkjet printing. There are several advantages to using the above methods. For example, freedom of substrate use facilitates the development of novel products. The low amount of material waste, low investment in production facilities, the versatility of the printing system, and many other benefits make PE ideal for low-cost electronics production. In addition, the data-driven nature of digital printing manufacturing methods allows fast manufacturing runs and a short time cycle from design to manufacturing, which all translate into shorter delivery times in manufacturing. \nInkjet printing technology is currently in a phase of proving its technological viability in the low-cost and high-volume manufacture of electronics. However, in technology development such change is only possible by demonstrating the reliability, durability, and applicability of the existing or novel electronic applications. In this work, inkjet printing technology was studied from the viewpoint of materials science and its potential to integrate electronic applications. The basic research concentrated on defining ink and substrate materials, their interactions, and on processing the materials with R&amp;D/pilot line inkjet printers which all are commercially available in the technology. The applied research focused on electronic component manufacture, on selectively applying existing conventional or novel functional materials, and on defining viable material alternatives. The technology development consisted of evaluating printed structures and their materials in terms of environmental and mechanical reliability.
The compiler as a validation and evaluation tool (2004)

Like a processor executes flawlessly at different frequencies, a compiler should produce correct results at any optimization level. The Intel® Itanium® processor family with its new features, like the register stack engine and control- and data speculation, provides new and unique challenges for ported software and compiler technology. This paper describes validation and evaluation techniques that can be employed in compilation tools and can help to get a cleaner port of an application, a more robust compilation system and even insights into performance tuning opportunities. Using Itanium as a specific example, the paper explains why the register stack engine (RSE), the large register file, or control- and data speculation can potentially expose bugs in poorly written or compiled software. It then demonstrates validation and evaluation techniques to find or expose these bugs. An evaluation team can employ them to find, eliminate and evaluate software bugs. A compiler team can use them to make the compiler more stable and robust. A performance analysis team can use them to uncover performance opportunities in an application. We demonstrate our validation and evaluation techniques on code examples and provide run-time data to indicate the cost of some of our methods.
Stability and Releasability of Adriamycin Ointment (1983)

The stability of adriamycin in macrogol ointment and hydrophilic ointment was studied for 4 weeks at room temperature and 5° by the bioassay and HPLC methods. Both preparations remained sufficiently stable through the 4 weeks after formulation. The releasability of adriamycin from these 2 ointment preparations was confirmed by using the diffusion tests of adriamycin based on chromatography and agar-agar methods. The results suggest that the diffusion of adriamycin may depend on the ointment base.
p H sensor using AlGaN∕GaN high electron mobility transistors with Sc2O3 in the gate region (2007)

Ungated AlGaN∕GaN high electron mobility transistors (HEMTs) exhibit large changes in current upon exposing the gate region to polar liquids. The polar nature of the electrolyte introduced leds to a change of surface charges, producing a change in surface potential at the semiconductor/liquid interface. The use of Sc2O3 gate dielectric produced superior results to either a native oxide or UV ozone-induced oxide in the gate region. The ungated HEMTs with Sc2O3 in the gate region exhibited a linear change in current between pH 3 and 10 of 37μA∕pH. The HEMT pH sensors show stable operation with a resolution of &amp;lt;0.1pH over the entire pH range. The results indicate that the HEMTs may have application in monitoring pH solution changes between 7 and 8, the range of interest for testing human blood.
Noise-dependent Gaussian mixture classifiers for robust rejection decision (2002)

Speech or speaker recognizers need to make a decision on either accepting or rejecting a recognized item, based on some measurement (e.g., likelihood) associated to the item. Distribution-based classification can be used to make the decision. In practical applications, the background noise level may adversely affect the distributions of the likelihoods and cause classification failure. A new decision mechanism is described, which treats the likelihoods as outcome of multidimensional Gaussian distributions with noise-dependent mean and covariance. The dependence on the noise is explicitly modeled as a polynomial function of noise level. The steps of estimating the decision parameters using the EM algorithm are given. Experimental results on in-car speech data show that the procedure, for noise ranging from a parked car (/spl sim/30 dB SNR) to highway (/spl sim/0 dB SNR) driving conditions, maintains a well-balanced decision performance between false rejection and false acceptance.
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability (2018)

Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. Here, we report the discovery of deubiquitinating activity in ZUFSP/C6orf113. High-resolution crystal structures of ZUFSP in complex with ubiquitin reveal several distinctive features of ubiquitin recognition and catalysis. Our analyses reveal that ZUFSP is a novel DUB with no homology to any known DUBs, leading us to classify ZUFSP as the seventh DUB family. Intriguingly, the minimal catalytic domain does not cleave polyubiquitin. We identify two ubiquitin binding domains in ZUFSP: a ZHA (ZUFSP helical arm) that binds to the distal ubiquitin and an atypical UBZ domain in ZUFSP that binds to polyubiquitin. Importantly, both domains are essential for ZUFSP to selectively cleave K63-linked polyubiquitin. We show that ZUFSP localizes to DNA lesions, where it plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage.
Hyperstructure model for chemical structure handling: Techniques for substructure searching (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHyperstructure model for chemical structure handling: Techniques for substructure searchingRobert D. Brown, Geoffrey M. Downs, Gareth Jones, and Peter WillettCite this: J. Chem. Inf. Comput. Sci. 1994, 34, 1, 47–53Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/ci00017a006https://doi.org/10.1021/ci00017a006research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
S-adenosyl-L-homocysteine hydrolase from mouse leukemic cells: Isolation and properties (1983)

S-Adenosyl-L-homocysteine hydrolase from mouse leukemic cells L1210 was purified to evident homogeneity with no concomitant enzymatic activities. The isoelectric point of the enzyme is 5.65 and the optimum temperatures for the synthesis and hydrolysis are 52 °C and 47 °C, respectively. The respective K M values for adenosine and S-adenosyl-L-homocysteine (SAH) are 3.8 and 4.4 μmol l -1 . The optimum pH value for the synthesis of SAH is 6.95-7.20 and for the hydrolysis 7.15-7.80. The enzyme is competitively inhibited by 9-( S )-(2,3-dihydroxypropyl)adenine and inactivated with both enantiomers of eritadenine and 3-(adenin-9-yl)-2-hydroxypropanoic acid.
Expression of the Epstein-Barr virus nuclear protein 2 in rodent cells (1986)

A 3.0-kilobase-pair Epstein-Barr virus (EBV) DNA segment necessary for lymphocyte immortalization encodes at least part of a nuclear protein (EBNA2) which is characteristically expressed in latently infected, immortalized cells. A 1.5-kilobase open reading frame within this DNA segment has now been inserted into a murine leukemia virus (MuLV)-derived expression vector (pZIP-NEO-SV(X)1) which provides for transcription of heterologous DNA but not for translational start. Transfection of the recombinant DNA into NIH 3T3 cells resulted in expression of a full-sized EBNA2 which localized to the cell nucleus. Significant new evidence is thereby provided that this 1.5 kilobase open reading frame includes a translational start site and encodes the entire EBNA2 protein. Transfection of the recombinant DNA into a helper cell line (psi am22b) providing amphotropic MuLV-packaging functions resulted in the release of a recombinant MuLV carrying the EBNA2 gene. This recombinant virus can infect rodent cells and convert them to stable EBNA2 expression. Rat-1 cells infected with the MuLV EBNA2 recombinant expressed EBNA2 and grew more rapidly in medium supplemented with 1 or 0.5% fetal calf serum than did Rat-1 cells infected with MuLV vector lacking EBNA2. The Rat-1 cells expressing EBNA2 remained contact inhibited, anchorage dependent, and nontumorigenic in nude mice. Different EBV isolates have one of at least two EBNA2 alleles. Despite divergence between the two alleles, a human serum recognized the prototype EBNA2 allele (EBNA2A) as well as the variant EBNA2B allele characteristic of some Burkitt tumor EBV isolates. The EBNA2B allele was also expressed from the MuLV-derived vector. The reproducible expression of EBNA2A or EBNA2B from these recombinant vectors will facilitate analysis of the EBNA2A and EBNA2B phenotypes.
Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors (1989)

A series of eight antiviral compounds complexed with human rhinovirus 14 (HRV-14) were previously shown to displace segments of polypeptide chains in the floor of the "canyon" by as much as 0.45 nm in C-alpha positions from the native conformation (J. Badger, I. Minor, M. J. Kremer, M. A. Oliveira, T. J. Smith, J. P. Griffith, D. M. A. Guerin, S. Krishnaswamy, M. Luo, M. G. Rossman, M. A. McKinlay, G. D. Diana, F. J. Dutko, M. Fancher, R. R. Rueckert, and B. A. Heinz, Proc. Natl. Acad. Sci. USA 85:3304-3308, 1988). Because the canyon is thought to serve as the viral receptor-binding site (M. G. Rossmann, E. Arnold, J. W. Erickson, E. A. Frankenberger, J. P. Griffith, H. J. Hecht, J. E. Johnson, G. Kamer, M. Luo, A. G. Mosser, R. R. Rueckert, B. Sherry, and G. Vriend, Nature [London] 317:145-153, 1985; M. G. Rossmann and R. R. Rueckert, Microbiol. Sci. 4:206-214, 1987), these compounds were assessed for their ability to block adsorption of HRV-14 to HeLa cell membrane receptors. In parallel experiments, the compounds were assessed directly for antiviral activity in an in vitro plaque reduction assay in intact HeLa cells. All eight compounds blocked the adsorption of 50% of HRV-14 at approximately the same concentration required to reduce the number of visible plaques by 50% (MIC). A structurally related compound which was inactive in the plaque reduction assay had no effect on HRV-14 binding. A drug-resistant mutant of HRV-14 (Leu-1188), which was less sensitive to the eight compounds in plaque reduction assays was similarly less sensitive in the adsorption assay. We propose that the conformational changes in the floor of the HRV-14 canyon induced by these compounds substantially decrease adsorption of the virion to its receptor. These results provide further evidence for the role of the HRV canyon in receptor binding.
A comparison of large-scale software installation methods on NT and UNIX (1998)

Our computing environment consists of hundreds of UNIX and NT-based computers. We have a coherent UNIX software installation model that scales comfortably to hundreds of machines. We have spent a great deal of time in the last year learning to understand the software installation and support mechanisms for a similarly large NT infrastructure. In this paper, we examine the underlying requirements for large-scale software installation support, and compare and contrast the NT and UNIX environments, identifying strong points, weak points, and issues. 1.
Impossibility of Differentially Private Universally Optimal Mechanisms (2010)

The notion of universally utility-maximizing privacy mechanism was recently introduced by Ghosh, Rough garden, and Sundararajan [STOC 2009]. These are mechanisms that guarantee optimal utility to a large class of information consumers, simultaneously, while preserving Differential Privacy [Dwork, McSherry, Nissim, and Smith, TCC 2006]. Ghosh, Rough garden and Sundararajan have demonstrated, quite surprisingly, a case where such a universally-optimal differentially-private mechanisms exists, when the information consumers are Bayesian. This result was recently extended by Gupte and Sundararajan [PODS 2010] to risk-averse consumers. Both positive results deal with mechanisms (approximately) computing a single count query (i.e., the number of individuals satisfying a specific property in a given population), and the starting point of our work is a trial at extending these results to similar settings, such as sum queries with non-binary individual values, histograms, and two (or more) count queries. We show, however, that universally-optimal mechanisms do not exist for all these queries, both for Bayesian and risk-averse consumers. For the Bayesian case, we go further, and give a characterization of those functions that admit universally-optimal mechanisms, showing that a universally-optimal mechanism exists, essentially, only for a (single) count query. At the heart of our proof is a representation of a query function f by its privacy constraint graph G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</sub> whose edges correspond to values resulting by applying f to neighboring databases.
Very stable mismatch duplexes: structural and thermodynamic studies on tandem G.cntdot.A mismatches in DNA (1992)

We have used ultraviolet melting techniques to compare the stability of several DNA duplexes containing tandem G.A mismatches to similar duplexes containing tandem A.G, I.A, and T.A base pairs. We have found that tandem G.A mismatches in 5'-Y-G-A-R-3' duplexes are more stable than their I.A counterparts and that they are sometimes more stable than tandem 5'-Y-T-A-R-3' sequences. This is not the case for tandem G.A mismatches in other base stacking environments, and it suggests that tandem G.A mismatches in 5'-Y-G-A-R-3' sequences have a unique configuration. In contrast to tandem 5'-G-A-3' mismatches, tandem 5'-A-G-3' mismatches were found to be unstable in all cases examined.
Audio indexing for broadcast news (1998)

In this paper we describe the IBM Audio-Indexing System which is a combination of a large vocabulary speech recognizer and a text-based information retrieval system. Our speech recognizer was used to produce the baseline transcripts for the NIST SDR97 evaluation. We report the performance of the system on the SDR-97 &amp;quot;known item retrieval&amp;quot; task and on a more pertinent TREC-style Audio-Indexing task. 1. Introduction The goal of an audio-indexing system is to provide the capability of searching and browsing through audio content. The system is formed by integrating information retrieval methods with large vocabulary continuous speech recognition. A large vocabulary continuous speech recognition system is used to to produce time aligned transcripts of the speech. Information retrieval techniques are then employed on these recognized transcripts to identify locations in the text that are relevant to the search request. These locations with time alignments then specify regions of the speech...
Development of cystic fibrosis and noncystic fibrosis airway cell lines (2003)

In this study, we utilized the reverse transcriptase component of telomerase, hTERT, and human papillomavirus type 16 (HPV-16) E6 and E7 genes to transform normal and cystic fibrosis (CF) human airway epithelial (HAE) cells. One cell line, designated NuLi-1 (normal lung, University of Iowa), was derived from HAE of normal genotype; three cell lines, designated CuFi (cystic fibrosis, University of Iowa)-1, CuFi-3, and CuFi-4, were derived from HAE of various CF genotypes. When grown at the air-liquid interface, the cell lines were capable of forming polarized differentiated epithelia that exhibited transepithelial resistance and maintained the ion channel physiology expected for the genotypes. The CF transmembrane conductance regulator defect in the CuFi cell lines could be corrected by infecting from the basolateral surface using adenoviral vectors. Using nuclear factor-kappaB promoter reporter constructs, we also demonstrated that the NuLi and CuFi cell lines retained nuclear factor-kappaB responses to lipopolysaccharide. These cell lines should therefore be useful as models for studying ion physiology, therapeutic intervention for CF, and innate immunity.
Nanoshell-polymer composites for photothermally modulated drug delivery (2001)

Summary form only given. Optically active gold nanoshells; have been incorporated into thermally, responsive copolymers of N-Isopropylacrylamide (NIPAAm) and acryl-amide (AAm) for the purpose of photothermally modulated drug delivery. The copolymer exhibits a lower critical solution temperature (LCST) that is slightly above body, temperature. When the temperature of the hydrogel exceeds its LCST, a rapid collapse occurs, expelling any material contained within the hydrogel. The gold nanoshells initiate a temperature increase, via targeted absorption of near IR light.
An Intelligent and Cost‐Effective Computer Dosing System for Individualizing FK506 Therapy in Transplantation and Autoimmune Disorders (1993)

The accuracy and precision of an intelligent dosing system (IDS) for FK506 in predicting doses to achieve target drug levels has been prospectively evaluated in transplant and autoimmune patients. For dose individualization, the knowledge base is updated with patient-specific feedback including the current dose, drug level, and the new target level. The study population of 147 patients consisted of 97 transplant patients (liver and kidney) and 50 patients with autoimmune disorders. Patients in the transplant study group were entered sequentially and followed as a cohort. Patients in the autoimmune study group were randomly assigned to one of three predefined FK506 concentration windows (low, 0.1-.3; medium, 0.4-.7; and high, 0.8-1.3 ng/mL) as part of a concentration controlled clinical trial. Predictions of steady-state plasma drug levels were made throughout the clinical course of autoimmune patients and during the first 6 weeks post-transplant in liver and kidney recipients. FK506 concentration in plasma was measured by a monoclonal antibody based ELISA assay. Accuracy was computed as the mean prediction error (mpe). Precision was computed as the root mean squared prediction error (rmspe). The accuracy of the IDS in each study group was as follows: 0.016 ng/mL (liver), -0.034 ng/mL (kidney), and -0.022 ng/mL (autoimmune). Because the 95% confidence interval included zero in each case, the IDS showed no bias. The precision of the IDS in each study group was as follows: 0.133 ng mL (liver), 0.1903 ng/mL (kidney), and 0.1188 ng/mL (autoimmune). These results indicate that the FK506 IDS is both accurate and very precise (reproducible) in transplant and autoimmune patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Diffusion Model of Hologram Formation in Dry Photopolymer Materials (1994)

Abstract The diffusion equation is solved in the low-order harmonic approximation, in order to describe the grating formation process in dry photopolymer materials. We describe how the ratio between diffusion and polymerization rates controls the process of grating formation. Nonlinearity and reciprocity failure are predicted. Experimental results are also shown which are in qualitative agreement with the theory.
Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-) (1991)

Inhibition of the pre-steady-state burst of nucleotide incorporation by a single incorrect nucleotide (nucleotide discrimination) was measured with the Klenow fragment of DNA polymerase I [KF(exo+)]. For the eight mispairs studied on three DNA sequences, only low levels of discrimination ranging from none to 23-fold were found. The kinetics of dNTP incorporation into the 9/20-mer at low nucleotide concentrations was also determined. A limit of greater than or equal to 250 s-1 was placed on the nucleotide off-rate from the KF(exo+)-9/20-dTTP complex in accord with nucleotide binding being at equilibrium in the overall kinetic sequence. The influence of the relatively short length of the 9/20-mer on the mechanism of DNA replication fidelity was determined by remeasuring important kinetic parameters on a 30/M13-mer with high homology to the 9/20-mer. Pre-steady-state data on the nucleotide turnover rates, the dATP(alpha S) elemental effect, and the burst of dAMP misincorporation into the 30/M13-mer demonstrated that the kinetics were not affected by the length of the DNA primer/template. The effects on fidelity of two site-specific mutations, KF(polA5) and KF(exo-), were also examined. KF(polA5) showed an increased rate of DNA dissociation and a decreased rate of polymerization resulting in less processive DNA synthesis. Nevertheless, with at least one misincorporation event, that of dAMP into the 9/20-mer, KF(polA5) displays an increased replication fidelity.(ABSTRACT TRUNCATED AT 250 WORDS)