gebhart/patrepeval huggingface dataset:
Plug and Play System Architecture (1995)

１ Ｐｌｕｇ ａｎｄ Ｐｌａｙの展開（完璧なマシン；ＩＳＡ 不完全な標準；ＥＩＳＡとマイクロチャネル ほか） ２ ＩＳＡ／ＥＩＳＡのＰｌｕｇ ａｎｄ Ｐｌａｙ（ＩＳＡ／ＥＩＳＡ Ｐｌｕｇ ａｎｄ Ｐｌａｙ；ＰｎＰデバイスの電源投入状態；コンフィギュレーションポート ほか）
Serotypic characterization of rotaviruses derived from asymptomatic human neonatal infections (1985)

Nineteen rotavirus strains derived from asymptomatic neonates (seven from England, five from Australia, two from Venezuela, and five from Sweden) were successfully cultivated in primary African green monkey kidney cell cultures, serotyped by plaque reduction neutralization tests, subgrouped by indirect enzyme-linked immunosorbent assay, and electropherotyped by polyacrylamide gel electrophoresis. All 19 strains were shown to fall into one of the four known human serotypes; serotype 1 (all Venezuelan strains), serotype 2 (all Swedish strains), serotype 3 (all Australian strains), or serotype 4 (all English strains). Hyperimmune guinea pig serum raised against the Venezuelan strain (M37) neutralized not only serotype 1 (strain Wa) but also serotype 4 (strain St. Thomas no. 3) viruses to a similar degree. The English, Australian, and Venezuelan isolates were found to belong to subgroup 2, and the Swedish strains were subgroup 1 viruses. The potential importance of these rotaviruses obtained from neonates as possible vaccine candidates is discussed.
Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology (2003)

A strategy to deplete eosinophils from the lungs of ovalbumin (OVA)-sensitized/challenged mice was developed using antibody-mediated depletion. Concurrent administration [viz. the peritoneal cavity (systemic) and as an aerosol to the lung (local)] of a rat anti-mouse CCR3 monoclonal antibody resulted in the abolition of eosinophils from the lung such that the airway lumen was essentially devoid of eosinophils. Moreover, perivascular/peribronchial eosinophil numbers were reduced to levels indistinguishable from saline-challenged animals. This antibody-mediated depletion was not accompanied by effects on any other leukocyte population, including, but not limited to, T cells and mast cells/basophils. In addition, no effects were observed on other underlying allergic inflammatory responses in OVA-treated mice, including OVA-specific immunoglobulin production as well as T cell-dependent elaboration of Th2 cytokines. The ablation of virtually all pulmonary eosinophils in OVA-treated mice (i.e., without concurrent effects on T cell activities) resulted in a significant decrease in mucus accumulation and abolished allergen-induced airway hyperresponsiveness. These data demonstrate a direct causative relationship between allergen-mediated pulmonary pathologies and eosinophils.
Reduced-complexity digital predistortion for massive MIMO (2017)

A novel reduced-complexity digital predistortion (DPD) solution is presented in this paper. The proposed DPD can suppress the unwanted distortions due to power amplifier (PA) nonlinearity and I/Q modulator impairments in direct conversion transmitters using reduced-bandwidth filtered basis functions. Moreover, the DPD parameter estimation is based on very simple decorrelation based closed-loop processing and reduced-bandwidth observation, thus further reducing the overall complexity. The proposed DPD can be used in large array or massive MIMO systems with large number of radio transceivers and PAs, where reducing the complexity of the DPD processing is very critical.
Biological effects of narrow band pulsed electric fields (2007)

This paper describes the process of narrow band pulsed electric fields (NPEFs) and its effect on mammalian cells. The NPEF consists of a pulse modulated sinusoidal wave (PMSW), which allows delivery of well-defined electric fields in terms of frequency, field strength and deposition energy to the biological systems. 100 mus long sinusoidal electric fields with a frequency of 0.02, 2 or 50 MHz and field strengths of up to 2 kV/cm are applied to CHO cells with variation in the DNA density in the cells investigated by means of Acridine Orange assay. The experiments indicate that 50 MHz fields cause DNA degradation without cell membrane defects, while 0.02 MHz fields lead to an increase in membrane permeability which is similar to the effect known as electroporation. The intermediate frequency of 2 MHz influences both the membrane and DNA. It is demonstrated that the MHz range narrowband electric fields with the amplitude level of 1 kV/cm cause intracellular effects in mammalian cells.
Exposure to House-Dust Mite Allergen (Der pI) and the Development of Asthma in Childhood (1990)

In addition to genetic factors, exposure in early childhood to house-dust mite allergens is an important determinant of the subsequent development of asthma.
Evaluation of the Mechanical Environment During Distraction Osteogenesis (1998)

Physical forces have been hypothesized to direct the process of bone regeneration during distraction osteogenesis. However, despite significant clinical experience, relatively little is known about how the mechanics of distraction influence bone formation. This study investigated net fixator forces and strains in the distraction callus during bilateral lengthening of tibiae in New Zealand White rabbits. Distractions yielded a classic viscoelastic response with a sharp increase in fixator force, followed immediately by significant relaxation. Tension acting on mesenchymal gap tissue caused by distraction was estimated to reach more than 30 N by the time full lengthening was achieved. Average maximum cyclic strains within the distraction zone during ambulation were estimated to be 14% to 15% and supported by the results of fluoroscopic imaging. Paradigms for fracture healing have hypothesized that such strains are incompatible with new bone formation. The documented clinical success of distraction osteogenesis at stimulating large volumes of new bone suggests that other mechanisms that warrant additional investigation may be at work during distraction.
Rational Identification of Lightning Derivative Disasters by Strong Convective Weather Monitoring Data in Southern China——A Case Study in Guangzhou Development Region (2015)

Analytic and identification direction for rational identification of lightning derivative disasters by strong convective weather monitoring data in southern China were introduced. Taking identification cases of lightning disaster in Guangzhou Development Region as the background,according to the characteristics in the region that large high-precision enterprises were more,lightning derivative disasters occurred frequently in thunderstorm season,and the actual situation that time of the affected enterprise applying for lightning disaster scene identification lagged,combining Technical Specifications of Lightning Disaster Investigation( QX / T103-2009),qualitative analysis of lightning derivative disaster was put forward under the weather condition of strong convection in southern China by using weather monitoring data( Doppler sounding radar data,lightning positioning monitoring data,atmospheric electric field data,rainfall data,wind direction and force),and was optimized by technical means( metallographic method and remanence law). The research could put forward efficient and convenient analytical thinking and for lightning derivative disaster,and further optimize accuracy and credibility of lightning disaster investigation.
Cell-surface receptor for thyroid hormone and tumor cell proliferation (2006)

Integrin αVβ3 is a structural protein of the plasma membrane that transduces signals from extracellular matrix proteins and has recently been shown to contain a novel receptor for thyroid hormone. Thyroid hormone signals are converted by αVβ3 into mitogen-activated protein kinase (MAPK) (ERK1/2) activation and downstream intracellular events in the cell nucleus. The latter include post-translational modification of the nuclear thyroid hormone receptor (TRβ1) and complex cellular or tissue responses, such as hormone-induced angiogenesis via basic fibroblast growth factor release. The integrin receptor for thyroid hormone has been shown to mediate proliferative effects of the hormone on certain tumor cell lines, including murine glioma/glioblastoma cells and human breast cancer (MCF-7) cells. More than one mechanism may account for this hormonal action, but in vitro studies indicate a direct hormonal action on cellular proliferation. Other possible mechanisms involve indirect actions via the release of tumor growth factors and effects on cell migration. In the intact organism, support of tumor growth by thyroid hormone is postulated to include angiogenesis. Crosstalk between the integrin thyroid hormone receptor and the epidermal growth factor receptor on the plasma membrane may be another mechanism by which thyroid hormone may modify tumor cell growth. Tetraiodothyroacetic acid (tetrac) is an iodothyronine analog that has no agonist activity at the integrin receptor, but inhibits binding of l-thyroxine and 3,5,3´-triiodo-l-thyronine to the receptor, preventing MAPK activation and consequent actions downstream of MAPK. In vitro studies and a preliminary in vivo experiment indicate that tetrac blocks the action of thyroid hormone on tumor cell proliferation. Both unmodified tetrac and tetrac reformulated as a nanoparticle that does not gain access to the cell interior are under investigation in animal models as anticancer agents. Also under study is the susceptibility of other human cancer cell lines to induction of proliferation by physiological concentrations of thyroid hormone.
Tophaceous gout: quantitative evaluation by direct physical measurement. (2005)

This simple and reproducible method can be easily utilized in clinical trials and in practice as a measure of efficacy of urate-lowering treatment in tophaceous gout. Among factors contributing to variability in these measurements were the anatomic site of tophi and rater experience with the method. Restriction of measurements to well circumscribed hand or foot tophi could improve reliability, but major changes, as expected with effective therapy, can clearly be documented with this simple technique.
Experiencias en la proyección de la alfabetización informacional en una institución cubana (2005)

Se abordan los conceptos de alfabetizacion tecnologica y alfabetizacion informacional, asi como sus interrelaciones. Se presentan los atributos que permiten identificar a un individuo alfabetizado en tecnologias de la informacion y se operacionalizan por medio de los conceptos fundamentales, las capacidades intelectuales y las habilidades que exige el uso de las tecnologias de la informacion. Se explican las tecnicas, instrumentos y el metodo utilizado para desarrollar la proyeccion de alfabetizacion informacional para una institucion determinada. Se exponen los resultados del diagnostico del nivel de alfabetizacion informacional que poseen los usuarios de dicho centro. Finalmente, se muestra la correlacion que debe existir entre las normas, los indicadores y los resultados una vez terminadas las diferentes etapas del proceso de alfabetizacion.
Human ornithine-delta-aminotransferase. cDNA cloning and analysis of the structural gene. (1988)

Ornithine-delta-aminotransferase (OAT) is a nuclear-encoded, mitochondrial matrix enzyme which, in rat, is expressed as basal levels in most tissues but is induced in liver by high dietary protein and in kidney by estrogen and thyroxine administration. In man, the hereditary deficiency of OAT results in ornithine accumulation and the blinding disease gyrate atrophy of the choroid and retina. We cloned near full length rat and human liver OAT cDNAs and demonstrated OAT expression in a variety of tissues from each species. We mapped the human OAT structural gene to chromosome 10, cloned 40 kilobase pairs of genomic DNA containing the complete OAT structural gene, and determined its organization. It is 21 kilobase pairs in length, and contains 11 exons. Exon 2 has been absent from all cDNAs studied and was detected by homology to X-linked processed OAT pseudogenes. The 5'-flanking region of the OAT gene has features of housekeeping genes (GC enrichment and three Sp1 binding consensus sequences) and tissue-specific, inducible genes (TATA box-like element and two CCAAT boxes). A 22-base pair region of partial dyad symmetry containing homology to estrogen responsive elements overlaps the OAT transcription site. Another 5' sequence, GTATCCTGCCCTC, is homologous to sequences in the promoter regions of the genes of three urea cycle enzymes.
Nucleotide sequence of a cDNA encoding the chicken receptor protein kinase of the TGF-β receptor family (1993)

We have isolated RPK-2 cDNA from chick embryo cDNA library that encodes a receptor protein kinase of the TGF-beta receptor subfamily. The deduced amino acid sequence reveals the presence of a hydrophobic transmembrane helix and a kinase domain distantly related to type II receptor for TGF-beta. The kinase domain sequence is most similar to RPK-1 identified recently in the chick embryo. Several cysteine residues are contained in the amino-terminal ectodomain, suggesting the protein as a receptor for a peptide growth factor of the TGF-beta family.
Inhibitory effect of low‐level laser irradiation on LPS‐stimulated prostaglandin E2 production and cyclooxygenase‐2 in human gingival fibroblasts (2000)

It has been reported that lipopolysaccharide (LPS) from periodontal pathogens can penetrate gingival tissues and stimulate the production of prostaglandin E2 (PGE2), which is known as a potent stimulator of inflammation and bone resorption. Although biostimulatory effects of low-level laser irradiation such as anti-inflammatory results have been reported, the physiological mechanism is not yet clarified. The purpose of the present study was to determine the effect of laser irradiation on PGE2 production and cyclooxygenase (COX)-1 and COX-2 gene expression in LPS-challenged human gingival fibroblast (hGF) cells in vitro. hGF cells were prepared from healthy gingival tissues and challenged with LPS, and Ga-Al-As diode laser was irradiated to the hGF cells. The amount of PGE2 released in the culture medium was measured by radioimmunoassay, and mRNA levels were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). Irradiation with Ga-Al-As diode low-level laser significantly inhibited PGE2 production in a dose-dependent manner, which led to a reduction of COX-2 mRNA levels. In conclusion, low-level laser irradiation inhibited PGE2 by LPS in hGF cells through a reduction of COX-2 mRNA level. The findings suggest that low-level laser irradiation may be of therapeutic benefit against the aggravation of gingivitis and periodontitis by bacterial infection.
DegS and YaeL participate sequentially in the cleavage of RseA to activate the ς E -dependent extracytoplasmic stress response (2002)

All cells have stress response pathways that maintain homeostasis in each cellular compartment. In the Gram-negative bacterium Escherichia coli, the sigma(E) pathway responds to protein misfolding in the envelope. The stress signal is transduced across the inner membrane to the cytoplasm via the inner membrane protein RseA, the anti-sigma factor that inhibits the transcriptional activity of sigma(E). Stress-induced activation of the pathway requires the regulated proteolysis of RseA. In this report we show that RseA is degraded by sequential proteolytic events controlled by the inner membrane-anchored protease DegS and the membrane-embedded metalloprotease YaeL, an ortholog of mammalian Site-2 protease (S2P). This is consistent with the mechanism of activation of ATF6, the mammalian unfolded protein response transcription factor by Site-1 protease and S2P. Thus, mammalian and bacterial cells employ a conserved proteolytic mechanism to activate membrane-associated transcription factors that initiate intercompartmental cellular stress responses.
ABCC3 and OCT1 Genotypes Influence Pharmacokinetics of Morphine in Children (2014)

Our data suggest that besides bodyweight, OCT1 and ABCC3 genotypes play a significant role in the pharmacokinetics of intravenous morphine and its metabolites in children.
Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background. (1992)

A murine interferon (IFN) alpha/beta receptor was cloned from the IFN-sensitive L1210 cell line on the basis of its homology with the human receptor. A combination of methods that includes the screening of random-primed and oligo(dT)-primed cDNA libraries and polymerase chain reactions with a single-side specificity was used. At the amino acid level, the murine IFN-alpha/beta shows 46% identity with its human counterpart. Both human WISH cells presenting a low sensitivity to mouse IFN and a murine L1210 mutant subline that does not express the receptor have been stably transfected with the murine IFN-alpha/beta receptor. Whereas transfected human cells became sensitive to a limited number of mouse IFN-alpha/beta subtypes, the transfected murine L1210 mutant was found to be fully complemented and became sensitive to all mouse IFN-alpha/beta subtypes tested, including those that were not active on transfected human cells. These results strongly suggest that the receptor described here is implicated in the mediation of the activities of all murine IFN-alpha/beta subtypes.
Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes (1998)

Evidence has been accumulating that shows that insulin-dependent diabetes is subject to immunoregulation. To determine whether cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is involved, we injected anti-CTLA-4 mAb into a TCR transgenic model of diabetes at different stages of disease. When injected into young mice, months before they would normally become diabetic, anti-CTLA-4 induced diabetes rapidly and essentially universally; this was not the result of a global activation of T lymphocytes, but did reflect a much more aggressive T cell infiltrate in the pancreatic islets. These effects were only observed if anti-CTLA-4 was injected during a narrow time window, before the initiation of insulitis. Thus, engagement of CTLA-4 at the time when potentially diabetogenic T cells are first activated is a pivotal event; if engagement is permitted, invasion of the islets occurs, but remains quite innocuous for months, if not, insulitis is much more aggressive, and diabetes quickly ensues.
3D Building Detection and Modeling from Aerial LIDAR Data (2006)

This paper presents a method to detect and construct a 3D geometric model of an urban area with complex buildings using aerial LIDAR (Light Detection and Ranging) data. The LIDAR data collected from a nadir direction is a point cloud containing surface samples of not only the building roofs and terrain but also undesirable clutter from trees, cars, etc. The main contribution of this work is the automatic recognition and estimation of simple parametric shapes that can be combined to model very complex buildings from aerial LIDAR data. The main components of the detection and modeling algorithms are (i) Segmentation of roof and terrain points. (ii) Roof topology Inference. We introduce the concept of a roof-topology graph to represent the relationships between the various planar patches of a complex roof structure. (iii) Parametric roof composition. Simple parametric roof shapes that can be combined to create a complex roof structure of a building are recognized by searching for sub-graphs in its roof-topology graph. (iv) Terrain Modeling. The terrain is identified and modeled as a triangulated mesh. Finally, we provide experimental results that demonstrate the validity of our approach for rapid and automatic building detection and geometric modeling with real LIDAR data. We are able to model cities and other urban areas at the rate of about 10 minutes per sq. mile on a low-end PC.
Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil) (2011)

The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction because of a contagious cancer known as Devil Facial Tumor Disease. The inability to mount an immune response and to reject these tumors might be caused by a lack of genetic diversity within a dwindling population. Here we report a whole-genome analysis of two animals originating from extreme northwest and southeast Tasmania, the maximal geographic spread, together with the genome from a tumor taken from one of them. A 3.3-Gb de novo assembly of the sequence data from two complementary next-generation sequencing platforms was used to identify 1 million polymorphic genomic positions, roughly one-quarter of the number observed between two genetically distant human genomes. Analysis of 14 complete mitochondrial genomes from current and museum specimens, as well as mitochondrial and nuclear SNP markers in 175 animals, suggests that the observed low genetic diversity in today's population preceded the Devil Facial Tumor Disease disease outbreak by at least 100 y. Using a genetically characterized breeding stock based on the genome sequence will enable preservation of the extant genetic diversity in future Tasmanian devil populations.
Introduction (1991)

Journal Article Introduction Get access E. S. E. S. Search for other works by this author on: Oxford Academic Google Scholar The Musical Quarterly, Volume 75, Issue 4, Winter 1991, Pages 1-s–1, https://doi.org/10.1093/mq/75.4.1-s Published: 01 December 1991
C2-domains, Structure and Function of a Universal Ca2+-binding Domain (1998)

A vast amount of protein sequence data accumulated over recent years has revealed that protein modules are widespread in nature. Many intracellular and extracellular proteins consist, in part or fully, of combinations of protein modules. C2-domains, together with SH2, PTB, PH, SH3, WW, and PDZ domains, are typical examples of intracellular protein modules. These modules form independently folding domains of 80–160 residues with characteristic binding properties; C2-domains bind Ca2+ and phospholipids, SH2 and PTB domains phosphotyrosine-containing sequences, PH domains phosphatidylinositol phosphates, SH3 and WW domains proline-rich sequences, and PDZ domains C-terminal sequences.
Mitigation of Quantum Dot Cytotoxicity by Microencapsulation (2011)

When CdSe/ZnS-polyethyleneimine (PEI) quantum dots (QDs) are microencapsulated in polymeric microcapsules, human fibroblasts are protected from acute cytotoxic effects. Differences in cellular morphology, uptake, and viability were assessed after treatment with either microencapsulated or unencapsulated dots. Specifically, QDs contained in microcapsules terminated with polyethylene glycol (PEG) mitigate contact with and uptake by cells, thus providing a tool to retain particle luminescence for applications such as extracellular sensing and imaging. The microcapsule serves as the "first line of defense" for containing the QDs. This enables the individual QD coating to be designed primarily to enhance the function of the biosensor.