gebhart/patrepeval huggingface dataset:
Continuous queries in oracle (2007)

a feature that incorporates stream and complex event processing into an RDBMS, the first such attempt in commercial databases. The feature is based on the concept of query difference and allows us to monitor real time changes to the query as the result of changes to its underlying tables. The result of a continuous query can be deposited into historical tables or queues for further asynchronous de-queuing, or can invoke a synchronous trigger for procedural processing. The main contribution of our CQ engine is that it allows us to react to complex scenarios of changes to data such as mixed INSERT, DELETE and UPDATE changes, unlike the existing stream processing systems that deal with INSERTS only. We support a wide range of query shapes including inner, semi and anti-joins, aggregates and window functions. More details are given to the efficient computation of query difference for general cases and their optimizations based on semantic constraints. They are shown to improve the response time for practical cases by more than an order of magnitude. We also show how delaying CQ re-computation can improve its performance by batch processing the changes to the base tables. 1.
Selective and simultaneous removal of dibenzothiophene and 4-methyldibenzothiophene using double-template molecularly imprinted polymers on the surface of magnetic mesoporous silica (2017)

The double-template molecularly imprinted polymer on the surface of magnetic mesoporous silica could be separated by applying an external magnet.
Structure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frame (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure determination of a tetrasaccharide: transient nuclear Overhauser effects in the rotating frameAksel A. Bothner-By, R. L. Stephens, Jumee Lee, Christopher D. Warren, and R. W. JeanlozCite this: J. Am. Chem. Soc. 1984, 106, 3, 811–813Publication Date (Print):February 1, 1984Publication History Published online1 May 2002Published inissue 1 February 1984https://pubs.acs.org/doi/10.1021/ja00315a069https://doi.org/10.1021/ja00315a069research-articleACS PublicationsRequest reuse permissionsArticle Views1359Altmetric-Citations1560LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase (2002)

We purified human plasma lysophospholipase D that produces physiologically active lysophosphatidic acid and showed that it is a soluble form of autotaxin, an ecto-nucleotide pyrophosphatase/phosphodiesterase, originally found as a tumor cell motility-stimulating factor. Its lower K(m) value for a lysophosphatidylcholine than that for a synthetic substrate of nucleotide suggests that lysophosphatidylcholine is a more likely physiological substrate for autotaxin and that its predicted physiological and pathophysiological functions could be mediated by its activity to produce lysophosphate acid, an intercellular mediator. Recombinant autotaxin was found to have lysophospholipase D activity; its substrate specificity and metal ion requirement were the same as those of the purified plasma enzyme. The activity of lysophospholipase D for exogenous lysophosphatidylcholine in human serum was found to increase in normal pregnant women at the third trimester of pregnancy and to a higher extent in patients in threatened preterm delivery, suggesting its roles in induction of parturition.
Nanostructured metals and alloys : processing, microstructure, mechanical properties and applications (2011)

Part 1 Processing of bulk nanostructured metals and alloys: Production of bulk nanostructured metals and alloys by severe plastic deformation (SPD) Bulk nanostructured metals and alloys produced by accumulative roll-bonding Nanocrystalline metals and alloys prepared by mechanical attrition Processing of nanostructured steels by solid reaction Processing of bulk nanocrystalline metals and alloys by electrodeposition Bulk nanocrystalline and nanocomposite alloys produced from amorphous phase Severe plastic deformation and production of nanostructured alloys by machining. Part 2 Microstructure: Deformation structures including twins in nanograined pure metals Microstructure and mechanical properties of nanostructured ferrous alloys by equal-channel angular pressing Characteristic structures and properties of nanostructured metals prepared by plastic deformation. Part 3 Mechanical properties: Strengthening mechanisms in nanocrystalline metals Elastic and plastic deformation in nanocrystalline metals Mechanical properties of multi-scale metallic materials Enhanced ductility and its mechanisms in nanocrystalline metallic materials Mechanical behavior of nanostructured metals based on molecular dynamics computer simulations Surface deformation and mechanical behavior of nanostructured alloys Fatigue behaviour in nanostructured metals Superplastic deformation in nanocrystalline metals and alloys Creep and high temperature deformation in nanostructured metals and alloys. Part 4 Applications: Processing of nanostructured metal and metal-matrix coatings by thermal and cold spraying Nanocoatings for commercial and industrial applications Application of nanostructured steel sheets to automotive body structures Production processes for nanostructured wires, bars and strips Nanostructured plain carbon-manganese (C-Mn) steel sheets by ultra-fast cooling and short interval multi-pass hot rolling.
Lymphotoxin Prevention of Diethylnitrosamine Carcinogenesis In Vivo<xref ref-type="fn" rid="fn2">2</xref> (1982)

Development of intervention measures to control cancer would be facilitated by being able to monitor in vivo carcinogenesis by in vitro quantitation of early indices of neoplastic transformation to assess the in vivo effectiveness of preventive-therapeutic measures. Pregnant Syrian golden hamsters were used in an in vivo-in vitro transplacental model of carcinogenesis to determine the extent that in vivo administration of immunologic hormone preparations along with chemical carcinogen would prevent morphologic transformation assessed in vitro. Pregnant hamsters at 10-11 days of gestation were given injections ip of 3 mg diethylnitrosamine (DENA)/100 g body weight and were killed 2 days later when fetal cells were seeded for colony formation. The frequency of morphologically transformed colonies was assessed after 7 days of growth. Cloning efficiency and mean transformation frequency after DENA exposure were 3.6% and 1 X 10(-4) per cell seeded, respectively. The ip injection of an immunologic hormone preparation reduced the transformation frequency by 46%. The hormone preparation, containing 10,000 U of lymphotoxin but no detectable interferon, was the ultrafiltered lymphokines (greater than 10,000 mol wt) from phytohemagglutinin-stimulated hamster peritoneal leukocytes. The effect of lymphotoxin on cocarcinogenic exposure of fetal cells to DENA in vivo followed by X-irradiation in vitro was also determined. Cells exposed to 250 rad in vitro had a cloning efficiency of 0.5% and a transformation frequency of 0.4 X 10(-4) per cell seeded. After DENA injection and X-irradiation, the transformation frequency increased to 1 X 10(-4) and was inhibited 64% by lymphotoxin in vivo. Thus immunologic hormones (e.g., lymphotoxin) can prevent carcinogenesis in vivo. Furthermore, in vitro quantitation of transformation is a rapid means for evaluating therapeutic and autochthonous effector mechanisms for their ability to prevent or otherwise modulate carcinogenesis in vivo.
The Release of DNA into Serum and Synovial Fluid (1971)

Abstract In 5 of 15 patients receiving high dose corticosteroids for a variety of disorders, and in 7 of 11 patients undergoing cardiac surgery involving periods of extra‐corporeal circulation, circulating DNA was detected. DNA was also detected in 41 of 63 synovial fluid samples tested. It is suggested that release of DNA is a relatively common phenomenon and may follow a variety of causes of cellular injury. The release of this antigen in SLE patients with circulating antiDNA antibodies may provide an opportunity for in vivo immune complex formation and resultant renal damage.
An 80-ns 1-Mb flash memory with on-chip erase/erase-verify controller (1990)

An internal erase and erase-verify control system has been implemented in an electrically erasable, reprogrammable, 80-ns 1-Mb flash memory, which is suitable for in-system reprogram applications. The memory utilizes a one-transistor type cell with a cell area of 10.4 mu /sup 2/. The die area is 32.3 mm/sup 2/. An erase mode is initiated by a 50-ns pulse. An erase and erase-verify sequence is automatically conducted in a chip without any further external control. The internal status can be checked through a status-polling mode. The 80-ns access time results from advanced sense amplifiers as well as low-resistance polysilicide word lines and scaled periphery transistors. To realize high-sensitivity, high-speed sense circuits, a pMOS transistor (whose gate is connected to its drain) is used as a load transistor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expression of CRISPR/Cas single guide RNAs using small tRNA promoters (2015)

The in vivo application of CRISPR/Cas-based DNA editing technology will require the development of efficient delivery methods that likely will be dependent on adeno-associated virus (AAV)-based viral vectors. However, AAV vectors have only a modest, ∼4.7-kb packaging capacity, which will necessitate the identification and characterization of highly active Cas9 proteins that are substantially smaller than the prototypic Streptococcus pyogenes Cas9 protein, which covers ∼4.2 kb of coding sequence, as well as the development of single guide RNA (sgRNA) expression cassettes substantially smaller than the current ∼360 bp size. Here, we report that small, ∼70-bp tRNA promoters can be used to express high levels of tRNA:sgRNA fusion transcripts that are efficiently and precisely cleaved by endogenous tRNase Z to release fully functional sgRNAs. Importantly, cells stably expressing functional tRNA:sgRNA precursors did not show a detectable change in the level of endogenous tRNA expression. This novel sgRNA expression strategy should greatly facilitate the construction of effective AAV-based Cas9/sgRNA vectors for future in vivo use.
Synthesis and Characterization of Heteroarotinoids Demonstrate Structure Specificity Relationships (1998)

Heteroarotinoids are synthetic retinoids derived from trans-retinoic acid and the arotinoid structures and include a heteroatom in a five- or six-membered cyclic ring. This is the first systematic study of influences of the heteroatom, ring size, number of aryl groups, and terminal side chain on retinoid receptor specificity. Two new heteroarotinoids were synthesized and characterized. Although all heteroarotinoids activated RAR receptors, two dominant associations between structure and specificity were identified across all compounds. The six-membered ring conferred increased RARbeta specificity over the five-membered ring. The sulfur atom conferred greater specificity for RARgamma than the oxygen atom. RARalpha specificity was attenuated by a combination of influences from the heteroatom and aryl groups. In summary, the heteroatom and cyclic ring size exerted dominant effects, while the number of aryl rings and terminal side chain had attenuating effects on retinoid receptor specificity of heteroarotinoids.
New surgical options for the failing heart. (1999)

Heart failure is common in patients aged over 65 years, and is the fourth leading cause of hospitalization in the United States. Treatment of congestive heart failure involves remodeling the cardiac chamber with ventricular dilatation. New approaches to resolve this problem include medical therapies (digoxin, diuretics, ACE inhibitors, beta-blockers and phosphodiesterase inhibitors) to stabilize patients, followed by chamber remodeling. As yet, surgical intervention in advanced heart failure has been contraindicated, but newly evolving strategies show significant promise. It appears possible that patients can receive surgical therapy to improve cardiac function, followed by state-of-the-art medical therapy for congestive heart failure. This combined medical/surgical approach has led to the evolution of a new subspecialty within cardiology that deals with the management of heart failure.
Optical path technologies: a comparison among different cross-connect architectures (1996)

The introduction of optical technology in the path layer of the transport network is expected to allow scalable and modular networks to be realized. In this paper, different optical cross-connect architectures, based either on space division or wavelength division switching, are analyzed. A comparative investigation is accomplished considering three issues of primary importance: cross-connect modularity, complexity, and transmission performance. In particular, the transmission performance of a generic path through the network is evaluated by upgrading a previously published analytical model, so to more accurately take into account the in-band crosstalk arising in the cross-connect.
Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010)

Nanomaterials induce cell specific responses resulting in variable toxicity and subsequent cell fate based on the type of exposed cell. Our results indicate that the composition and size of nanomaterials as well as the target cell type are critical determinants of intracellular responses, degree of cytotoxicity and potential mechanisms of toxicity.
Interconnection Network for Structured Low-Density Parity-Check Decoders (2005)

Most structured codes use the group-and-permute design approach in which rows and columns are divided into groups of the same size. Row/column groups and individual row-column are connected by some permutation. A general group-and-permute decoder requires an interconnection network for group-to-group communication. In this paper we suggest the use of self-routed Benes networks based on the communication pattern of LDPC codes. Bipartite edge coloring is used to schedule messages such that there are no switch network output conflicts. The looping routing algorithm for Benes networks is used to compute switching codes. Both scheduling information and switching codes are pre-computed and stored for each design code since they do not change in the lifetime of the code
Two-step Membrane Binding by Equinatoxin II, a Pore-forming Toxin from the Sea Anemone, Involves an Exposed Aromatic Cluster and a Flexible Helix (2002)

Equinatoxin II (EqtII) belongs to a unique family of 20-kDa pore-forming toxins from sea anemones. These toxins preferentially bind to membranes containing sphingomyelin and create cation-selective pores by oligomerization of 3-4 monomers. In this work we have studied the binding of EqtII to lipid membranes by the use of lipid monolayers and surface plasmon resonance (SPR). The binding is a two-step process, separately mediated by two regions of the molecule. An exposed aromatic cluster involving tryptophans 112 and 116 mediates the initial attachment that is prerequisite for the next step. Steric shielding of the aromatic cluster or mutation of Trp-112 and -116 to phenylalanine significantly reduces the toxin-lipid interaction. The second step is promoted by the N-terminal amphiphilic helix, which translocates into the lipid phase. The two steps were distinguished by the use of a double cysteine mutant having the N-terminal helix fixed to the protein core by a disulfide bond. The kinetics of membrane binding derived from the SPR experiments could be fitted to a two-stage binding model. Finally, by using membrane-embedded quenchers, we showed that EqtII does not insert deeply in the membrane. The first step of the EqtII binding is reminiscent of the binding of the evolutionarily distant cholesterol-dependant cytolysins, which share a similar structural motif in the membrane attachment domain.
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy (2004)

Aberrant alpha-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the Lewy inclusion bodies associated with the disease. Little is known, however, about the pathways by which wild-type alpha-synuclein is normally degraded. We found that wild-type alpha-synuclein was selectively translocated into lysosomes for degradation by the chaperone-mediated autophagy pathway. The pathogenic A53T and A30P alpha-synuclein mutants bound to the receptor for this pathway on the lysosomal membrane, but appeared to act as uptake blockers, inhibiting both their own degradation and that of other substrates. These findings may underlie the toxic gain-of-function by the mutants.
Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade (2018)

Our study reveals an association between Chibby expression and cancer aerobic glycolysis, which highlights the importance of Wnt/β-catenin pathway in regulation of energy metabolism of NPC. These results indicate that Chibby and PDK1 are the potential target for NPC treatment.
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates (2006)

The safety and efficacy of peripheral venous administration of a self-complementary adeno-associated viral vector encoding the human FIX gene (scAAV-LP1-hFIXco) was evaluated in nonhuman primates for gene therapy of hemophilia B. Peripheral vein infusion of 1x10(12) vg/kg scAAV-LP1-hFIXco pseudotyped with serotype 8 capsid, in 3 macaques, resulted in stable therapeutic expression (more than 9 months) of human FIX (hFIX) at levels (1.1+/-0.5 microg/mL, or 22% of normal) that were comparable to those achieved after direct delivery of the same vector dose into the portal circulation (1.3+/-0.3 microg/mL, or 26% of normal). Importantly, the pattern of vector biodistribution after systemic and portal vein administration of scAAV-LP1-hFIXco was almost identical. Additionally, comparable levels of gene transfer were achieved in macaques with preexisting immunity to AAV8 following peripheral vein administration of 1x10(12) vg/kg AAV5-pseudotyped scAAV-LP1-hFIXco. This confirms that alternative serotypes can circumvent preexisting naturally acquired immunity to AAV. Thus, peripheral venous administration of AAV5 and AAV8 vectors is safe and as effective at transducing the liver in nonhuman primates as direct vector administration into the portal circulation. These results should make vector administration to patients, especially those with a severe bleeding diathesis, significantly easier and safer.
Effects of Interferon-γ 1b on Biomarker Expression in Patients with Idiopathic Pulmonary Fibrosis (2004)

In a recent study of IFN-gamma 1b in 330 patients with idiopathic pulmonary fibrosis (IPF), progression-free survival was unchanged; however, a trend toward lower mortality was seen in IFN-gamma 1b-treated patients compared with placebo-treated patients (9.9 vs. 16.7%; p = 0.08). The purpose of this randomized, double-blind, placebo-controlled trial was to characterize molecular effects of subcutaneous IFN-gamma 1b (200 microg) thrice weekly for 6 months versus placebo in 32 patients with IPF. Messenger RNA in transbronchial lung biopsies and bronchoalveolar lavage cell pellet and protein levels in bronchoalveolar lavage fluid (BALF) and plasma were evaluated. After IFN-gamma 1b treatment, IFN-inducible T cell-alpha chemoattractant/CXCL11 (a chemokine with immunomodulatory, antiangiogenic, and defensin-like antimicrobial properties) increased in BALF (p = 0.016) and plasma (p < 0.001); BALF levels of epithelial neutrophil-activating protein-78/CXCL5 (p = 0.054), platelet-derived growth factor A (p = 0.033), and Type I procollagen (p = 0.096) were lower; and IFN-gamma levels were higher (p = 0.093) versus placebo. For messenger RNA in transbronchial biopsies, trends (p > 0.05 and <or= 0.10) associated with IFN-gamma 1b treatment included an increase in IFN-inducible T cell-alpha chemoattractant/CXCL11, a decrease in elastin, and smaller increases for Type III procollagen and platelet-derived growth factor B. Changes in biomarkers of fibrosis, angiogenesis, proliferation, immunomodulation, and antimicrobial activity suggest that IFN-gamma 1b may affect IPF through multiple pathways.
Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry (2005)

For the first time approved antiretroviral drugs, i.e. protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI), were quantified in dried blood spots (DBS) from HIV/AIDS patient whole blood samples as the basis for therapeutic drug monitoring (TDM) by a robust simultaneous liquid chromatography/tandem mass spectrometry (LC/MS/MS) method. This study included seven PI (amprenavir, nelfinavir, indinavir, lopinavir, saquinavir, ritonavir, atazanavir) and two NNRTI (nevirapine, efavirenz). LC/MS/MS coupling was realized using a Phenomenex Synergy Max RP LC column (150 x 2 mm, 4 micro) in combination with a tandem mass spectrometer (API 2000, Applied Biosystems/MDS Sciex Concord) operating in positive and negative multiple reaction monitoring (MRM) mode with reserpine as internal standard. DBS samples were punched out and extracted with 50:50 MeOH/0.2 M ZnSO4 (v/v) as extraction reagent. The method performance data for the drugs in DBS like limits of detection (LOD, 8-70 ng/mL), lower limits of quantification (LLOQ, 41-102 ng/mL), linearity (R2, 0.9981-0.9999), linear concentration ranges (41-10.000 ng/mL), accuracies (92-113%), recoveries (62-94%), and ion suppression were investigated and are comparable to data obtained from human plasma, which is the current standard matrix for TDM of PI and NNRTI. In this case, off-line plasma sample preparation was performed by means of simple protein precipitation with 80:20 methanol/0.2 M ZnSO4 (v/v) as precipitation reagent. Significant correlations between real patient plasma and DBS were obtained for samples containing lopinavir, atazanavir, ritonavir, saquinavir, and efavirenz. DBS preparation as sampling alternative is well suited and practicable for TDM minimizing the high infection risk of HIV/AIDS samples and may facilitate sample mailing.