gebhart/patrepeval huggingface dataset:
ISOLATION OF MUMPS VIRUS FROM CHILDREN WITH ACUTE LOWER RESPIRATORY TRACT DISEASE1 (1971)

Journal Article ISOLATION OF MUMPS VIRUS FROM CHILDREN WITH ACUTE LOWER RESPIRATORY TRACT DISEASE Get access HJORDIS M. FOY, HJORDIS M. FOY 2 2Reprint requests to Dr. Foy, School of Public Health and Community Medicine, Department of Epidemiology and International Health, University of Washington, Seattle, Washington, 98195. Search for other works by this author on: Oxford Academic PubMed Google Scholar MARION K. COONEY, MARION K. COONEY Search for other works by this author on: Oxford Academic PubMed Google Scholar CARRIE E. HALL, CARRIE E. HALL Search for other works by this author on: Oxford Academic PubMed Google Scholar EVA BOR, EVA BOR Search for other works by this author on: Oxford Academic PubMed Google Scholar AVRON J. MALETZKY AVRON J. MALETZKY Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 94, Issue 5, November 1971, Pages 467–472, https://doi.org/10.1093/oxfordjournals.aje.a121343 Published: 01 November 1971 Article history Received: 29 April 1971 Published: 01 November 1971
Regulation of Extravascular Coagulation by Microvascular Permeability (1985)

Extravascular coagulation is a prominent feature of such important pathological processes as cellular immunity and neoplasia and has been thought to result from procoagulants associated with the inflammatory or tumor cells peculiar to these entities. It was found that increased microvascular permeability alone is sufficient to induce equivalent extravascular coagulation in several normal tissues. The results indicate that saturating levels of procoagulant are present even in normal tissues and that microvascular permeability is a rate-limiting step in extravascular coagulation.
The potential benefits of advanced therapeutic modalities in the treatment of diabetic foot wounds (2000)

This article discusses the advantages and disadvantages of primary wound healing as compared with primary amputation in individuals with chronic diabetic foot wounds. The authors review the potential benefits of vascular surgical procedures and advanced dressings, including two of the most promising modalities in modern wound care: growth factors and bioengineered skin. In this era of cost-conscious health-care administration, it is incumbent on the practitioner to consider not only the basic science of wound care, but also the economic aspect of treatment rendered. These various interventions, dressings, growth factor delivery systems, and new modalities could significantly reduce healing time, thereby reducing the risk of infection, hospitalization, and amputation while improving quality of life. If so, they may be truly cost-effective.
Designing Therapies That Target Tumor Blood Vessels (1997)

Traditional cancer treatments seek to attack cancer cells directly, with surgery, radiation, or chemotherapy. But a new wave of therapies is attempting an indirect strike: shutting off the blood vessels through which tumors get the oxygen and nutrients they need to live and grow. Recent work suggests that this might be done with drugs, some naturally occurring, that can prevent tumors from forming the new blood vessels they need. Alternately, as a report appearing on page 547 suggests, it might be possible to shrink or even eliminate tumors by administering agents that trigger clot formation in tumor-feeding vessels.
<title>Scene reconstruction from distorted images using self-calibration of camera parameters</title> (1992)

In this paper, we propose a new method for reconstructing a scene from different views through a high-distortion lens camera. Unlike other approaches, no a priori calibrations nor specific test patterns are required. Several pairs of correspondence between input images are used to estimate intrinsic parameters such as focal length and distortion coefficients. From these correspondences, relative movement of the camera between input images is computed as rotation matrices. We assumed radial lens distortion, modeled with a third order polynomial with two distortion coefficients, which covers highly distorted zoom lenses. Since we allow distortion with two coefficients and focal length to be unknown, it is not easy to get these three parameters explicitly from the correspondence alone. To avoid time consumption and the problem of local minima, we take the following steps: uniform searching in the reduced dimension; fitting a function to get a better guess of focal length; and polishing solutions by repeating the uniform search to get the final coefficients of distortion. The total number of evaluations is remarkably reduced by this multistage optimization. Some experimental results are presented, showing that more than 5% of lens distortion is reduced and the rotation of the camera is recovered, and we show a registration of four outdoor pictures.
Acceleration of Skeletal Muscle Regeneration in a Rat Skeletal Muscle Injury Model by Local Injection of Human Peripheral Blood-Derived CD133-Positive Cells (2009)

Muscle injuries in sport activities can pose challenging problems in traumatology and sports medicine. The best treatment for muscle injury has not been clearly established except for the conservative treatment that is routinely performed. We investigated the potential of human adult CD133+ cells to contribute to skeletal muscle regeneration in an athymic rat model. We tested whether CD133+ cells locally transplanted to the skeletal muscle lacerated models could (a) induce vasculogenesis/angiogenesis, (b) differentiate into endothelial and myogenic lineages, and (c) finally promote histological and functional skeletal myogenesis. Granulocyte colony stimulating factor-mobilized peripheral blood (PB) CD133+ cells, PB mononuclear cells, or phosphate-buffered saline was locally injected after creating a muscle laceration in the tibialis anterior muscle in athymic rats. After treatment, histological and functional skeletal myogenesis was observed significantly in the CD133+ group. The injected CD133+ cells differentiated into endothelial and myogenic lineages. Using real-time polymerase chain reaction analysis, we found that the gene expressions related to microenvironment conduction for host angiogenesis, fibrosis, and myogenesis were ideally up/downregulated. Our results show that CD133+ cells have the potential to enhance the histological and functional recovery from skeletal muscle injury rather via indirect contribution to environment conduction for muscular regeneration. It would be relatively easy to purify this cell fraction from PB, which could be a feasible and attractive autologous candidate for skeletal muscle injuries in a clinical setting. These advantages could accelerate the progression of cell-based therapies for skeletal muscle injuries from laboratory to clinical implementation.
SUBACUTE AND CHRONIC TOXICITY STUDIES OF TRIETHYLENETETRAMINE DIHYDROCHLORIDE (TJA-250) BY ORAL ADMINISTRATION TO F-344 RATS (1998)

Triethylenetetramine dihydrochloride (trientine-2HCl, TJA-250), a copper chelating agent used to treat Wilson's disease, was administered orally to male and female F-344 rats for 4 or 8 weeks at dosages of 0, 100, 350 or 1200 mg/kg/day or for 26 weeks at dosages of 50, 175 or 600 mg/kg/day. 4 or 8-week study. Two males receiving 1200 mg/kg/day died during week 8 of treatment. In males receiving 1200 mg/kg/day during weeks 5 to 8 of treatment, body weight gain and food consumption were decreased and hunched posture and thin build were observed. During week 4 or 8 of treatment urinalysis revealed, for males receiving 100 mg/kg/day or animals receiving 350 mg/kg/day or more, increased electrolyte outputs possibly due to the hydrochloride nature of trientine-2HCl, with low plasma alkaline phosphatase activities evident in animals receiving 350 or 1200 mg/kg/day. After 4 and 8 weeks, and during 8 weeks of treatment, high lung weights and bronchiolar epithelium hypertrophy and broncho-alveolar pneumonia were recorded for animals receiving 1200 mg/kg/day, and submucosal acute inflammation within the glandular region of the stomach was recorded for males receiving 350 or 1200 mg/kg/day and in all treated female groups. 26-week study. One male receiving 175 mg/kg/day and three males receiving 600 mg/kg/day died, showing lung changes. The body weight gain of animals receiving 600 mg/kg/day was slightly decreased. Blood chemistry and urinalysis examinations showed changes similar to those indicated in the 4- or 8-week study. The low plasma copper concentrations seen in males receiving 600 mg/kg/day, the slightly low liver copper concentrations found in animals receiving 600 or 175 mg/kg/day and the high urinary copper concentrations found in all treated groups, are attributed to the pharmacological action of trientine-2HCl. Histopathology revealed a dosage-related incidence and severity of focal chronic interstitial pneumonitis accompanied by fibrosis of the alveolar walls in females receiving 175 mg/kg/day or more and all treated male groups, but no significant pathological changes in the stomach. Apart from the histological changes found in the lung, all the above changes were reversible. In conclusion, the NOAEL of trientine-2HCl in this 26-week study was considered to be 50 mg/kg/day for females and less than 50 mg/kg/day for males.
Systemic Therapy of Atopic Dermatitis in Children and Adults (2011)

Systemic therapy is required in patients with severe atopic dermatitis (AD) refractory to adequate topical therapy. The aim of a systemic therapy is the rapid and efficient improvement of skin symptoms and pruritus in acute exacerbation and/or the long-term control of severe chronic disease. A number of immunosuppressive and immunomodulating substances are available that may efficiently reduce skin inflammation and thus lead to a relief of symptoms including pruritus. The excellent effects of cyclosporine as short-term as well as maintenance therapy have been documented in several studies in children and adults. Furthermore, other immunosuppressive substances such as azathioprine, mycophenolate mofetil and methotrexate are effective in patients with moderate to severe AD. Intravenous immunoglobulins and γ-interferon exert immunomodulatory effects and thus may improve severe AD. Biological agents are a new approach in AD therapy since they may specifically target cells, cytokines or mediators involved in the pathogenesis of AD.
Solicitation-based Forwarding for Sensor Networks (2006)

Delivering sufficient fidelity to sensor network applications is challenging because unpredictable wireless links, network dynamics, and the presence of transitional regions in sensor networks impact the delivery of packets (i.e., fidelity) to the sink. One of the major reasons for this problem is due to the non-responsive nature of forwarding mechanisms commonly implemented in experimental sensor networks. Existing routing protocols implemented in these networks typically base their forwarding decision-making on some form of statistical observations regarding past communications or the quality of past beacon signals received by communicating nodes. This approach fails, however, to capture the link conditions at the exact time of forwarding packets across the wireless link, limiting the aggregate forwarding capability of the network. In this paper, we argue that the forwarding decision of a sensor device should be based not on historical information but on the instantaneous link conditions at the exact time of packet communications, and propose, solicitation-based forwarding (SOFA), a highly-responsive hop-by-hop routing protocol that results in increased application fidelity. SOFA represents a cost-effective, on-demand scheme that makes use of simple solicitation-based handshakes between a sender and multiple potential receivers at each wireless hop to negotiate the best forwarding path to a target destination (i.e., sink) when events occur in the sensor field. We present the detailed design, implementation, and experimental evaluation of SOFA in a 36-node Mica2 testbed using TinyOS, and discuss its measured performance benefits in comparison to the TinyOS standard routing protocol widely used by the experimental sensor network community
Hairy1 acts as a node downstream of Wnt signaling to maintain retinal stem cell-like progenitor cells in the chick ciliary marginal zone (2009)

In the vertebrate retina, stem cell-like progenitor cells are maintained in a distinct region called the ciliary marginal zone (CMZ). Canonical Wnt signaling regulates the maintenance of the progenitor cells in the CMZ. However, its downstream molecular mechanisms have remained largely unclear. Here, we show that chick Hairy1, an established Notch signaling effector, mediates the Wnt-dependent maintenance of CMZ progenitor cells in chicken. Interestingly, unlike other developmental contexts in which Hes gene expression is regulated by Notch signaling, Hairy1 expression in the CMZ is regulated by Wnt signaling. Hairy1 is necessary and sufficient for the expression of a set of molecular markers characteristic of the CMZ, and Wnt2b fails to induce CMZ markers when Hairy1 activity is inhibited. Furthermore, microarray analysis identifies multiple Wnt-responsive transcription factors that activate Hairy1 expression. We thus propose that Hairy1 functions as a node downstream of Wnt signaling to maintain progenitor cells in the chick CMZ.
Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis. (1991)

The structures and hemolytic and bactericidal activities of three bombinin-like peptides, or BLP-1-3, from the skin of Bombina orientalis are described. The peptides were isolated from the skin of B. orientalis and sequenced by tandem mass spectrometry and are amphipathic, cationic peptides of 25-27 amino acids in length. The sequence of the most abundant member (BLP-1) is: Gly-Ile-Gly-Ala-Ser-Ile-Leu-Ser-Ala-Gly-Lys-Ser-Ala-Leu-Lys-Gly-Leu- Ala-Lys-Gly-Leu-Ala-Glu-His-Phe-Ala-Asn-NH2. All three peptides were found to share considerable, but not complete, homology with bombinin, an antimicrobial, hemolytic peptide first isolated by Michl and Csordas (Csordas, A., and Michl, A. (1970) Monatsh. Chem. 101, 182-189) from the skin of Bombina variegata. The BLPs have been assayed for antibiotic and hemolytic activity and found to be more potent than magainin 2 (a related antimicrobial peptide from Xenopus laevis) in their ability to kill bacteria. However, no significant hemolytic activity was found for these peptides which suggests a selectivity for prokaryotic over eukaryotic membranes. The molecular basis for antibacterial activity is presumed to be due to their predicted amphipathic alpha-helical structures which is supported by circular dichroism measurements that found significant helical content (63-69% alpha-helix) in 40% trifluoroethanol. Last, a cDNA library was constructed from the skin of B. orientalis and screened with an oligonucleotide probe complementary to the COOH terminus of BLP-1. Several clones were isolated and sequenced that encode BLP-1 and BLP-3, as well as an additional peptide (BLP-4) that differs by two amino acid substitutions from BLP-3.
Cases for Justus: Preparing a Case Database for a Hypertext Information Retrieval System (1990)

This paper describes the automatic conversion of a volume of Butterworth's All England Law Reports from the magnetic tapes used to produce the traditional printed book to a version to run under the Guide hypertext system The conversion was completed as part of the Justus project, which aims to provide an integrated hypertext law library containing diverse documents all of which have been converted by the Justus programs to hypertext documents. The paper begins by discussing the origins and development of law reports. It then discusses in details the information structure of the All England series. It describes Guide, Justus and the method of conversion, then goes on to describe the access modes offered by the system It concludes by considering the next steps in the research program
Resonance Raman spectra of adsorbed species at solid-gas interfaces. 2. p-Nitrosodimethylaniline and p-dimethylaminoazobenzene adsorbed on semiconductor oxide surfaces (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResonance Raman spectra of adsorbed species at solid-gas interfaces. 2. p-Nitrosodimethylaniline and p-dimethylaminoazobenzene adsorbed on semiconductor oxide surfacesJames F. Brazdil and Ernest B. YeagerCite this: J. Phys. Chem. 1981, 85, 8, 1005–1014Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/j150608a016https://doi.org/10.1021/j150608a016research-articleACS PublicationsRequest reuse permissionsArticle Views88Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1 (2002)

The tumor suppressor p53 is a labile protein whose level is known to be regulated by the Mdm-2-ubiquitin-proteasome degradation pathway. We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation. A mutant p53 (p53([22,23])), which is resistant to Mdm-2-mediated degradation, was susceptible to dicoumarol-induced degradation. This finding indicates that the NQO1-regulated proteasomal p53 degradation is Mdm-2-independent. The tumor suppressor p14(ARF) and the viral oncogenes SV40 LT and adenovirus E1A that are known to stabilize p53 inhibited dicoumarol-induced p53 degradation. Unlike Mdm-2-mediated degradation, the NQO1-regulated p53 degradation pathway was not associated with accumulation of ubiquitin-conjugated p53. In vitro studies indicate that dicoumarol-induced p53 degradation was ubiquitin-independent and ATP-dependent. Inhibition of NQO1 activity in cells with a temperature-sensitive E1 ubiquitin-activating enzyme induced p53 degradation and inhibited apoptosis at the restrictive temperature without ubiquitination. Mdm-2 failed to induce p53 degradation under these conditions. Our results establish a Mdm-2- and ubiquitin-independent mechanism for proteasomal degradation of p53 that is regulated by NQO1. The lack of NQO1 activity that stabilizes a tumor suppressor such as p53 can explain why humans carrying a polymorphic inactive NQO1 are more susceptible to tumor development.
CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. (1992)

In T lymphocytes, signal transduction through the CD2 adhesion molecule requires surface expression of the CD3-Ti T-cell receptor (TCR) complex. In contrast, in natural killer (NK) cells, CD2 functions in the absence of a TCR. Because the TCR on T lymphocytes and the CD16 low-affinity IgG Fc receptor (Fc gamma receptor type III) complex on NK cells share a common CD3 zeta subunit, we reasoned that CD3 zeta may be critical for CD2 signaling in T lymphocytes and NK cells. Here we show that transfection of a cDNA encoding a transmembrane form of CD16 into TCR- variants of the Jurkat T-cell line results in CD16 expression in association with endogenous CD3 zeta homodimers and restores CD2 signaling function. To test directly the role of CD3 zeta in CD2 triggering, we then transfected human CD2 into each of two murine T-T hybridomas that express TCRs containing either a full-length CD3 zeta subunit or a truncated CD3 zeta subunit incapable of transducing signals. Despite expression of equivalent surface levels of TCR, CD2-mediated signaling is seen only in the T cells containing wild-type CD3 zeta. These findings show that (i) CD16 on NK cells is functionally equivalent to the TCR on T lymphocytes for coupling CD2 to signaling pathways and (ii) CD2 signal transduction depends upon the CD3 zeta subunit of the TCR complex and, by inference, the CD3 zeta subunit of the CD16 complex.
Peptides derived from human insulin‐like growth factor‐II mRNA binding protein 3 can induce human leukocyte antigen‐A2‐restricted cytotoxic T lymphocytes reactive to cancer cells (2010)

Insulin-like growth factor-II mRNA binding protein 3 (IMP-3) is an oncofetal protein expressed in various malignancies including lung cancer. This study aimed to identify immunogenic peptides derived from IMP-3 that can induce tumor-reactive and human leukocyte antigen (HLA)-A2 (A*02:01)-restricted cytotoxic T lymphocytes (CTL) for lung cancer immunotherapy. Forty human IMP-3-derived peptides predicted to bind to HLA-A2 were analyzed to determine their capacity to induce HLA-A2-restricted T cells in HLA-A2.1 (HHD) transgenic mice (Tgm). We found that three IMP-3 peptides primed HLA-A2-restricted CTL in the HLA-A2.1 Tgm. Among them, human CTL lines reactive to IMP-3 (515) NLSSAEVVV(523) were reproducibly established from HLA-A2-positive healthy donors and lung cancer patients. On the other hand, IMP-3 (199) RLLVPTQFV(207) reproducibly induced IMP-3-specific and HLA-A2-restricted CTL from healthy donors, but did not sensitize CTL in the HLA-A2.1 Tgm. Importantly, these two IMP-3 peptide-specific CTL generated from healthy donors and cancer patients effectively killed the cancer cells naturally expressing both IMP-3 and HLA-A2. Cytotoxicity was significantly inhibited by anti-HLA class I and anti-HLA-A2 monoclonal antibodies, but not by the anti-HLA-class II monoclonal antibody. In addition, natural processing of these two epitopes derived from the IMP-3 protein was confirmed by specific killing of HLA-A2-positive IMP-3-transfectants but not the parental IMP-negative cell line by peptide-induced CTL. This suggests that these two IMP-3-derived peptides represent highly immunogenic CTL epitopes that may be attractive targets for lung cancer immunotherapy.
The Chemokine CXCL1/Growth Related Oncogene Increases Sodium Currents and Neuronal Excitability in Small Diameter Sensory Neurons (2008)

Many studies on the role of chemokines in pain conditions have focused on their rapid and indirect effects on neurons, via release of inflammatory mediators from immune and glial cells. Our study suggests that GRO/KC may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis.