gebhart/patrepeval huggingface dataset:
Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice (1993)

The effects of recombinant human interleukin-11 (rhIL-11) on in vivo mouse megakaryocytopoeisis were examined. Normal C57Bl/6 mice and splenectomized C57Bl/6 mice were treated for 7 days with 150 micrograms/kg rhIL-11 administered subcutaneously. In normal mice, peripheral platelet counts were elevated compared with vehicle-treated controls after 3 days of rhIL-11 treatment and remained elevated until day 10. Splenectomized mice treated with rhIL-11 showed elevated peripheral platelet counts that were similar in magnitude to normal rhIL-11-treated mice. However, on day 10 the platelet counts in rhIL-11- treated, splenectomized mice were no longer elevated. Analysis of bone marrow megakaryocyte ploidy by two-color flow cytometry showed an increase, relative to controls, in the percentage of 32N megakaryocytes in both normal and splenectomized animals treated with rhIL-11. In normal mice, the number of spleen megakaryocyte colony-forming cells (MEG-CFC) were increased twofold to threefold relative to controls after 3 and 7 days of rhIL-11 treatment, whereas the number of bone marrow MEG-CFC were increased only on day 7. The number of MEG-CFC in the bone marrow of rhIL-11-treated, splenectomized mice was increased twofold compared with controls on both days 3 and 7 of the study. These data show that in vivo treatment of normal or splenectomized mice with rhIL-11 increased megakaryocyte progenitors, stimulated endoreplication of bone marrow megakaryocytes, and increased peripheral platelet counts. In addition, results in splenectomized mice showed that splenic hematopoiesis was not essential for the observed increases in peripheral platelets in response to rhIL-11 administration.
Gossip fiercer than a tiger: Effect of workplace negative gossip on targeted employees’ innovative behavior (2019)

From a self-evaluation perspective, we explored the influence of negative workplace gossip on targeted employees’ innovative behavior. We surveyed 296 employees of 19 enterprises. The results of regression analysis showed that negative workplace gossip was negatively related to employees’ innovative behavior, that organization-based self-esteem mediated the relationship between negative workplace gossip and employees’ innovative behavior, and that employees’ creative selfefficacy moderated the relationship between organization-based self-esteem and employees’ innovative behavior, such that the positive relationship was stronger when employees’ creative self-efficacy was higher. Our findings offer insight into the potential harm of gossip in the workplace and contribute to delineating the underlying mechanism and boundary condition of the link between negative workplace gossip and employees’ innovative behavior. Theoretical and practical implications are discussed.
Treatment of hepatocellular carcinoma: too many options? (1994)

Prevention is the ideal approach to HCC. Surgical cure is rarely possible, and while numerous therapies may palliate symptoms, patient selection and the lack of randomized studies make their impact on median survival difficult to assess. Patients being treated for HCC should be enrolled on treatment protocols testing multimodality or new strategies.
Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy (2020)

BackgroundEpicardial injection of heart-derived cell products is safe and effective post-myocardial infarction (MI), but clinically-translatable transendocardial injection has never been evaluated. We sought to assess the feasibility, safety and efficacy of percutaneous transendocardial injection of heart-derived cells in porcine chronic ischemic cardiomyopathy.Methods and ResultsWe studied a total of 89 minipigs; 63 completed the specified protocols. After NOGA-guided transendocardial injection, we quantified engraftment of escalating doses of allogeneic cardiospheres or cardiosphere-derived cells in minipigs (n = 22) post-MI. Next, a dose-ranging, blinded, randomized, placebo-controlled (“dose optimization”) study of transendocardial injection of the better-engrafting product was performed in infarcted minipigs (n = 16). Finally, the superior product and dose (150 million cardiospheres) were tested in a blinded, randomized, placebo-controlled (“pivotal”) study (n = 22). Contrast-enhanced cardiac MRI revealed that all cardiosphere doses preserved systolic function and attenuated remodeling. The maximum feasible dose (150 million cells) was most effective in reducing scar size, increasing viable myocardium and improving ejection fraction. In the pivotal study, eight weeks post-injection, histopathology demonstrated no excess inflammation, and no myocyte hypertrophy, in treated minipigs versus controls. No alloreactive donor-specific antibodies developed over time. MRI showed reduced scar size, increased viable mass, and attenuation of cardiac dilatation with no effect on ejection fraction in the treated group compared to placebo.ConclusionsDose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy. The decreases in scar size, mirrored by increases in viable myocardium, are consistent with therapeutic regeneration.
PLA2G6 mutations in PARK14‐linked young‐onset parkinsonism and sporadic Parkinson's disease (2011)

Mutations of PLA2G6 gene have been lately proposed to be the causative gene for PARK14 in patients with autosomal recessive young-onset parkinsonism (YOPD). The role of PLA2G6 mutations as a risk factor for Parkinson's disease is not clear. To study the PLA2G6 mutations in PARK14-linked patients and its association with the onset of sporadic Parkinson's disease (sPD), sequencing and gene dosage analyses were carried out in 25 patients (onset age ≦30 years) then the identified variants were assessed in 956 sporadic PD (sPD) patients and 802 age-matched healthy controls. Four genetic variants were identified; one patient had homozygous c.991G > T (p.Asp331Tyr) mutation, two had compound heterozygous c.991G > T/c.1077G > A (p.Met358IlefsX) mutation, one had single c.1976A > G (p.Asn659Ser) mutation, and one patient had an exon 1 hetero-deletion. The c.1077G > A mutation resulted in a 4-bp deletion in leukocyte mRNA by activating a cryptic splice site in exon 7. Only p.Asp331Tyr was identified in four sPD patients and four controls. The onset age for PLA2G6 mutation carriers was younger than that for sPD (29.86 ± 8.59 vs. 56.84 ± 11.33 years, P = 0.0002). The analysis of previously reported PARK14 patients revealed that those who carried a truncated mutation tended to have a complicated phenotype and atrophies of cortex and cerebellum. In conclusion, PLA2G6 mutation was the second common genetic cause after PRKN mutation in our YOPD patients and might be a risk factor for early-onset PD in Han Chinese. Additionally, mutation data should be interpreted carefully because even a synonymous mutation could cause abnormal mRNA splicing.
Analysis of volatile flavor compounds of solidifying lily yoghurt (2012)

Volatile flavor compounds of fresh lily and solidifying lily yoghurt were analyzed by headspace solid phase microextraction(HS-SPME) combined with GC-MS. Results indicated that total 66 volatile flavor compounds were identified in fresh lily,mainly including hydro carbons,carboxylic acid,alcohols etc. 80 volatile flavor compounds in the solidifying lily yoghurt,and 64 volatile flavor compounds in the control,mainly including ketone,carboxylic acid,aldehydes,esters etc. The volatile flavor compound identified in the solidifying lily yoghurt keep less compounds of fresh lily,it was mainly new volatile flavor compounds that were produced from fermentaion of fresh lily and milk. Compared with the control yoghurt,the categories of volatile flavor compounds were almost the same,but there was some differences in the content of compounds,the typical compounds of diacetyl and ethyl acetate that had feature effects on flavor of yoghurt increased,while acetoin,aldehyde reduced.
Cross-talk between Wnt and Bone Morphogenetic Protein 2 (BMP-2) Signaling in Differentiation Pathway of C2C12 Myoblasts (2005)

Loss of function of the Wnt co-receptor, lipoprotein receptor-related protein 5, decreases bone formation, and a point mutation in this gene results in high bone mass, indicating the importance of this signaling pathway in bone formation. However, the exact mechanism is currently unknown. We examined a potential role for Wnt signaling and functional cross-talk of bone morphogenetic protein 2 (BMP-2) in osteoblast differentiation. To assess the contribution of Wnt, we generated C2C12 cells over-expressing Wnt3a or Wnt5a and treated these with BMP-2. We showed that expression of matrix extracellular phosphoglycoprotein was induced by BMP-2 in Wnt3a over-expressing C2C12 cells but not in Wnt5a over-expressing C2C12 cells. Over-expression of Wnt3a blocked BMP-2-induced inhibition of myotube formation in C2C12 cells when switched to low mitogen medium. In these cultures, expression of inhibitor of DNA binding/differentiation (Id) 1, a helix-loop-helix protein induced by BMP-2, decreased in stable Wnt3a- but not in Wnt5a-expressing cells. This suppression is mediated by a GC-rich region of the BMP-2-responsive element of the Id1 gene promoter, and interaction between Smad1/4 and beta-catenin is crucial for Wnt-mediated suppression of the BMP-2 response in C2C12 cells. Over-expression of the inhibitor of canonical Wnt signaling, Dickkopf, inhibits this suppression. In contrast, BMP-2 or Smad1/4 up-regulated Wnt3a or activated beta-catenin-induced lymphoid-enhancing factor 1/T cell factor-dependent transcriptional activity. These findings identify functional cross-talk of Id1 expression between Wnt and BMP signaling and demonstrate a novel mechanism for Wnt regulation of the BMP-2 response, linking Id1 expression to Wnt/beta-catenin signaling.
Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells (2005)

Transplantation of olfactory ensheathing cells (OECs) into the damaged rat spinal cord leads to directed elongative axonal regeneration and improved functional outcome. OECs are known to produce a number of neurotrophic molecules. To explore the possibility that OECs are neuroprotective for injured corticospinal tract (CST) neurons, we transplanted OECs into the dorsal transected spinal cord (T9) and examined primary motor cortex (M1) to assess apoptosis and neuronal loss at 1 and 4 weeks post-transplantation. The number of apoptotic cortical neurons was reduced at 1 week, and the extent of neuronal loss was reduced at 4 weeks. Biochemical analysis indicated an increase in BDNF levels in the spinal cord injury zone after OEC transplantation at 1 week. The transplanted OECs associated longitudinally with axons at 4 weeks. Thus, OEC transplantation into the injured spinal cord has distant neuroprotective effects on descending cortical projection neurons.
FIÉVET (Michel). – Les Enfants pauvres à l’école. La révolution scolaire de Jean-Baptiste de La Salle. Préface d’Arlette Farge, Paris, Imago, 2001. – 254 p. (2002)

Il est vraiment impossible de rendre compte d’un ouvrage qui revendique a ce point l’anachronisme comme principe de frequentation et de jugement du passe. Cela vaut pour la terminologie employee : l’introduction et la conclusion evoquent ainsi, a propos du xviie siecle, une « France qui pietine socialement », ou regne une « pensee unique », peuplee d’enfants « defavorises », « en mal de reperes », « astreints a la productivite » par les « nantis » et les « possedants-rentiers ». Cela vaut aus...
Human Growth (2003)

Many researchers and professionals need to be able to measure, assess and interpret human growth between birth and adulthood. However, much of the methodology is scattered in diverse literature. Human Growth: Assessment and Interpretation provides a complete reference to the field for all those who measure and assess child growth. It emphasises the interpretation of growth data taking into account the adjusted effects of influences such as genes, hormones and substance abuse during pregnancy, gives descriptions of normal and abnormal growth patterns, and of variant growth patterns such as failure-to-thrive and catch-up growth. Including methods to measure size and maturity, the judgement and interpretation of recorded data, evaluations of influences on growth and the significance of abnormal growth, it will be an essential source of information for pediatricians, human biologists, health workers, nutritionists, epidemiologists and others who are responsible for the health and welfare of children.
Femtosecond pulse phase measurement by spectrally resolved up-conversion: application to continuum compression (1992)

The authors have developed an extension of the usual cross-correlation method in order to get the amplitude and phase of a femtosecond light pulse. This is done by analyzing the spectra of the upconverted pulse obtained by mixing the initial pulse with the reference pulse delayed with different times. The theory is worked out in closed form for Gaussian pulses and then checked with simulations for arbitrary fields. It is shown that the phase derivative of any probed pulse can be directly recovered in the limit where the reference is narrowband. This technique is used to measure the chirp induced at the output of a femtosecond Ti:sapphire oscillator. This technique is then applied to the determination of the exact pulse shape of a 21-fs compressed continuum at 770 nm using, as a reference, the initial fundamental 65-fs pulse at 620 nm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Computer Glossary: The Complete Illustrated Dictionary, Ninth Edition with Cdrom (2000)

From the Publisher:
This classic computer volume - long the reference of choice for computer users at all levels - is now completely updated to contain more useful and current information than ever before, including brand new information on Internet and Web terminology. With 2,000 new and revised entries (for a grand total of more than 6,000) and more than 200 photographs and illustrations, The Computer Glossary is easily the most comprehensive source for computer terms and information ever compiled. It's really more than a dictionary - not only does it include computer concepts and terminology, but it also covers jargon, companies, products, and industry history. Perfect for wet-behind-the-ears Web surfers, techno nerds, and anybody in between, The Computer Glossary addresses everything from personal computers to mainframes, from networking to vendors to operating systems, and much more.
Molecular alterations associated with LNCaP cell progression to androgen independence (2004)

We have developed AI LNCaP cell models and identified several genes that are specifically expressed in these models. Elucidating the relative importance of these genetic changes will help define the molecular mechanism by which CaP progresses to androgen independence.
4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses (1997)

The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells after antigen- or mitogen-induced activation. Cross-linking of 4-1BB and the T cell receptor (TCR) on activated T cells has been shown to deliver a costimulatory signal to T cells. Here, we expand upon previously published studies by demonstrating that CD8+ T cells when compared with CD4+ T cells are preferentially responsive to both early activation events and proliferative signals provided via the TCR and 4-1BB. In comparison, CD28-mediated costimulatory signals appear to function in a reciprocal manner to those induced through 4-1BB costimulation. In vivo examination of the effects of anti-4-1BB monoclonal antibodies (mAbs) on antigen-induced T cell activation have shown that the administration of epitope-specific anti-4-1BB mAbs amplified the generation of H-2d-specific cytotoxic T cells in a murine model of acute graft versus host disease (GVHD) and enhanced the rapidity of cardiac allograft or skin transplant rejection in mice. Cytokine analysis of in vitro activated CD4+ and CD8+ T cells revealed that anti-4-1BB costimulation markedly enhanced interferon-gamma production by CD8+ T cells and that anti-4-1BB mediated proliferation of CD8+ T cells appears to be IL-2 independent. The results of these studies suggest that regulatory signals delivered by the 4-1BB receptor play an important role in the regulation of cytotoxic T cells in cellular immune responses to antigen.
Trivalent Ions Activate Abscisic Acid-Inducible Promoters through an ABI1-Dependent Pathway in Rice Protoplasts (2000)

The plant hormone abscisic acid (ABA) mediates many vital processes in plant growth and development, including seed dormancy, cell division, water use efficiency, and adaptation to drought, salinity, chilling, pathogen attack, and UV light. Our understanding of ABA signal transduction is fragmentary and would benefit from specific and facile probes of the process. Protoplasts from rice (Oryza sativa L. cv IR54) embryonic suspension cultures cotransformed with effector plasmids encoding the maize (Zea mays) VIVIPAROUS1 cDNA and/or the Arabidopsis dominant negative mutant (abi1-1) ABA-insensitive cDNA demonstrated genetic interactions of VIVIPAROUS1 and abi1-1 in transactivation of the ABA-inducible HVA1 promoter from barley (Hordeum vulgare), suggesting the mechanisms of these effectors are conserved among monocots and dicots. Trivalent ions have been shown to act as an effector of gene expression in plants and animals, although the mechanism of action is unknown. We show in two complementary transient ABA-inducible gene expression assays (beta-glucuronidase and luciferase enzymatic activities and quantitative flow cytometry of green fluorescent protein) that trivalent ions specifically interact with an ABI1-dependent ABA-signaling pathway leading to gene expression. Trivalent ions mimic ABA effects on gene expression and may be a useful tool to study ABA signaling.
A cytotoxic metabolite of Streptomyces sp. SC120 (2003)

During the course of the investigation of the antifungal metabolites against Peronophythora litchii from the fermentation broth of Streptomyces sp. SC120, an antibiotics that exhibited the cytotoxicity to CNE_(2) was isolated. By spectral (UV, IR, HRMS, ~(1)H-NMR, ~(13)C-NMR, ~(1)H-~(1)H COSY HMQC and HMBC) analyses, its structure was identified as pimprinine. The cytotoxicity of pimprinine to CNE_(2) was reported for the first time.
Using perceptual organization to extract 3D structures (1989)

The authors describe an approach to perceptual grouping for detecting and describing 3-D objects in complex images and apply it to the task of detecting and describing complex buildings in aerial images. They argue that representations of structural relationships in the arrangements of primitive image features, as detected by the perceptual organization process, are essential for analyzing complex imagery. They term these representations collated features. The choice of collated features is determined by the generic shape of the desired objects in the scene. The detection process for collated features is more robust than the local operations for region segmentation and contour tracing. The important structural information encoded in collated features aids various visual tasks such as object segmentation, correspondence processes, and shape description. The proposed method initially detects all reasonable feature groupings. A constraint satisfaction network is then used to model the complex interactions between the collations and select the promising ones. Stereo matching is performed on the collations to obtain height information. This aids in further reasoning on the collated features and results in the 3-D description of the desired objects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Transformation of Germanium Dioxide to Microporous Germanate 4-Connected Nets (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTransformation of Germanium Dioxide to Microporous Germanate 4-Connected NetsHailian Li and O. M. YaghiView Author Information Department of Chemistry and Biochemistry Arizona State University, Tempe, Arizona 85287-1604 Cite this: J. Am. Chem. Soc. 1998, 120, 40, 10569–10570Publication Date (Web):September 24, 1998Publication History Received7 July 1998Published online24 September 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/ja982384nhttps://doi.org/10.1021/ja982384nrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1279Altmetric-Citations135LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Crystals,Materials,Molecules,Organic reactions Get e-Alerts
Slepian-Wolf coding of multiple M-ary sources using LDPC codes (2004)

This paper presents a Slepian-Wolf coding of n correlated m-ary sources for LDPC codes. On applying the syndrome concept, multilevel codes with low-density parity-check (LDPC) codes can be used to approach the Slepian-Wolf limit at each level. The advantage of LDPC codes is that they can be designed for different correlation models between source outputs and the side information and approach the Slepian-Wolf limits. Specifically, for Slepian-Wolf coding of three sources, a design rule of rates for coding each source, which facilitates code design and allows multistage decoding was proposed.