gebhart/patrepeval huggingface dataset:
Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. (2001)

Midkine (MK), a heparin-binding growth factor, is overexpressed in a wide range of human carcinomas and is believed to contribute to tumorigenesis and tumor progression. To develop an antitumor reagent, we designed a phosphorothioate antisense oligodeoxynucleotide molecule based on the secondary structure of MK mRNA. The antisense MK at the dosage of 5 microM suppressed MK production by CMT-93 mouse rectal carcinoma cells after cationic liposome-mediated transfection, to 13% of that in control cultures. The growth of CMT-93 cells and their colony formation in soft agar were inhibited by the addition of the antisense MK, whereas the control reagent, the sense MK, showed no effects. On s.c. injection into nude mice, CMT-93 cells transfected with the antisense MK formed tumors much smaller than those by control cells. Finally, untreated CMT-93 cells were inoculated to nude mice, and 7 days later the antisense MK (50 microM) with atelocollagen was directly injected into the preformed tumor region to evaluate the curative effect; the injection was repeated at the interval of 2 weeks. During the period of 10-41 days after initiation of therapy, the rate of increase of tumor volume treated with the antisense MK was found to be about 4.2-fold lower than that seen after treatment with the sense MK. On this occasion, proliferation of tumor cells as estimated by 5-bromodeoxyuridine incorporation was strongly inhibited, whereas angiogenesis was less affected. These findings strongly suggested the usefulness of MK antisense oligodeoxynucleotide as a new reagent for cancer therapy.
Ring-LWE Ciphertext Compression and Error Correction (2017)

Some lattice-based public key cryptosystems allow one to transform ciphertext from one lattice or ring representation to another efficiently and without knowledge of public and private keys. In this work we explore this lattice transformation property from cryptographic engineering viewpoint. We apply ciphertext transformation to compress Ring-LWE ciphertexts and to enable efficient decryption on an ultra-lightweight implementation targets such as Internet of Things, Smart Cards, and RFID applications. Significantly, this can be done without modifying the original encryption procedure or its security parameters. Such flexibility is unique to lattice-based cryptography and may find additional, unique real-life applications.
Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy (2006)

Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with gold nanoshells embedded with Fe 3O4 nanoparticles. The Fe3O4 nanoparticles allow magnetic resonance imaging (MRI) for diagnosis, and the gold nanoshells enable photothermal therapy. By attaching an antibody to the Mag-GNS by a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH &amp;amp;amp; Co. KGaA.
Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues (2000)

Mutations of the APC gene are thought to be early events in the process of colorectal carcinogenesis. Although the complete function(s) of the APC gene product is not known, it has been shown that the APC protein interacts with beta-catenin in a multi-protein complex to regulate the level of expression of beta-catenin. Loss of normal APC protein function can lead to an accumulation of beta-catenin in the cytosol and the nucleus. Immunohistochemical methods were used to determine the relationship between APC and beta-catenin protein expression in human colonic tissues (150 normal, 9 hyperplastic, 58 adenomas and 83 carcinomas) and 12 paired samples of normal and cancer tissue in mouse colon. In all samples of normal human and mouse colonic mucosa and in human hyperplastic polyps both APC and beta-catenin immunoreactivity were present in colonocytes. APC expression was cytoplasmic, with maximal immunoreactivity in the goblet cells. beta-Catenin expression was predominantly localized to the plasma membrane, with no nuclear immunoreactivity. APC immunoreactivity was absent in all of the mouse adenocarcinomas and 83% of the human colon cancers. All of the human and mouse carcinomas had nuclear and cytoplasmic beta-catenin expression. In contrast, only 29% of the 58 colonic adenomas were completely negative for APC immunoreactivity. Regardless of the presence or absence of APC, all of the adenomas had cytoplasmic and nuclear beta-catenin immunoreactivity. Many colonic adenomas retain expression of full-length APC protein whereas it is usually lost in colorectal cancers. Regardless of the status of APC protein expression, beta-catenin protein was found in the cytoplasm and nucleus of all neoplastic colonic mucosa. The dissociation between loss of expression of APC and accumulation of beta-catenin in the nucleus suggests that inactivation of both alleles of the APC gene may not be required for beta-catenin nuclear accumulation in colonic adenomas.
Quantum dots for multimodal molecular imaging of angiogenesis (2010)

Quantum dots exhibit unique optical properties for bioimaging purposes. We have previously developed quantum dots with a paramagnetic and functionalized coating and have shown their potential for molecular imaging purposes. In the current mini-review we summarize the synthesis procedure, the in vitro testing and, importantly, the in vivo application for multimodal molecular imaging of tumor angiogenesis.
The Reduction of Chlorine on Carbon in AlCl[sub 3]-KCl-NaCl Melts (1972)

Using a rotating‐vitreous, carbon disk electrode, the kinetic parameters for chlorine reduction in an (57.5‐12.5‐30 mole per cent [m/o]) melt were determined. It was found that the reduction of chlorine occurs according to the paths
A Platform for Ultrasensitive and Selective Multiplexed Marker Protein Assay Toward Early-Stage Cancer Diagnosis (2007)

Multiplexed marker protein assay is critical in the diagnosis of complex diseases that cannot be diagnosed by detection of a single marker protein. Gold nanoparticle (Au NP) probes barcoded with reporter DNAs and magnetic microparticles functionalized with a capture antibody were developed for the multiplexed detection of three cancer marker proteins. Three types of Au NP probes were used and each Au NP probe was cofunctionalized with reporter (barcode) DNAs and a specific antibody for each corresponding target protein. Target proteins (antigens) were exposed to magnetic microparticles to form complexes and Au NP probes bound to the resulting target-magnetic microparticle complex through antigen-antibody interaction in a different region of the target protein. After magnetic separation of the complexes, barcode DNAs were released, hybridized with capture DNAs printed on a chip and then identified using a scanometric assay that involved silver amplification. Using this method, Mirkin and colleagues successfully demonstrated, for the first time, a highly selective and sensitive multiplexed protein assay against three cancer marker proteins at low picomolar concentration in a buffer of serum media.
Location Prediction Algorithms for Mobile Wireless Systems (2003)

Predicting the location of a mobile wireless user is an inherently interesting and challenging problem. Location prediction has received increasing interest over the past decade, driven by applications in location management, call admission control, smooth handoffs, and resource reservation for improved quality of service. It is likely that location prediction will receive even more interest in the future, especially given the increased availability and importance of location estimation hard-ware and applications.In this chapter, we present an overview of location prediction in mobile wireless systems. We do not attempt to provide a comprehensive survey of all techniques and applications, but offer instead a description of several types of algorithms used for location prediction. We classify them broadly into two types of approaches: (1) domain-independent algorithms that take results from Markov analysis or text compression algorithms and apply them to prediction, and (2) domain-specific algorithms that consider the geometry of user motion as well as the semantics of the symbols in the user's movement history. We briefly mention other algorithms using Bayesian or neural network approaches, and end with some concluding remarks.
Molecular cloning and expression of the human Δ7-sterol reductase (1998)

Inhibitors of the last steps of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development. Their molecular target is the Delta7-sterol reductase (EC 1.3.1.21), suspected to be defective in the Smith-Lemli-Opitz syndrome, a frequent inborn disorder of sterol metabolism. Molecular cloning of the cDNA revealed that the human enzyme is a membrane-bound protein with a predicted molecular mass of 55 kDa and six to nine putative transmembrane segments. The protein is structurally related to plant and yeast sterol reductases. In adults the ubiquitously transcribed mRNA is most abundant in adrenal gland, liver, testis, and brain. The Delta7-sterol reductase is the ultimate enzyme of cholesterol biosynthesis in vertebrates and is absent from yeast. Microsomes from Saccharomyces cerevisiae strains heterologously expressing the human cDNA remove the C7-8 double bond in 7-dehydrocholesterol. The conversion to cholesterol depends on NADPH and is potently inhibited by AY9944 (IC50 0.013 microM), BM15766 (IC50 1.2 microM), and triparanol (IC50 14 microM). Our work paves the way to clarify whether a defect in the delta7-sterol reductase gene underlies the Smith-Lemli-Opitz syndrome.
Pressure Dependent Highly Enantioselective Hydrogenation of Unsaturated β-Amino Acid Precursors (2001)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTPressure Dependent Highly Enantioselective Hydrogenation of Unsaturated β-Amino Acid PrecursorsDetlef Heller, Jens Holz, Hans-Joachim Drexler, Jutta Lang, Karlheinz Drauz, Hans-Peter Krimmer, and Armin BörnerView Author Information Institut für Organische Katalyseforschung an der Universität Rostock e.V., Buchbinderstr. 5/6, D-18055 Rostock, Germany, and dmc2, Abteilung EC−R, and Fine Chemicals Division, Degussa Hüls AG, Postfach 13 5, D-63403 Hanau, Germany [email protected].Cite this: J. Org. Chem. 2001, 66, 20, 6816–6817Publication Date (Web):September 1, 2001Publication History Received30 April 2001Published online1 September 2001Published inissue 1 October 2001https://pubs.acs.org/doi/10.1021/jo010445lhttps://doi.org/10.1021/jo010445lbrief-reportACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views545Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Catalytic reactions,Hydrogenation,Solvents,Stereoselectivity Get e-Alerts
Andrology: Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility (1993)

Glutathione therapy was used for 2 months in a placebo-controlled double-blind cross-over trial of 20 infertile patients with dyspermia associated with unilateral varicocele (VAR) or germ-free genital tract inflammation (INF). The patients received either glutathione (group 1) or placebo (group 2) for 2 months, then they crossed over to the alternative treatment for a further 2 months. The patients were randomly and blindly assigned to treatment (one i.m. injection every other day of either 600 mg glutathione or an equal volume of a placebo preparation). The standard semen analysis and the computer-assisted sperm motility analyses were carried out before treatment and during the trial. Statistical cross-over analysis, case-control study and treatment efficacy test were carried out on groups 1 and 2 and differences in the effects of therapy between VAR and INF patients with varicocele or inflammation were tested. Glutathione therapy demonstrated a statistically significant positive effect on sperm motility, in particular on the percentage of forward motility, the kinetic parameters of the computerized analysis and on sperm morphology. The findings of this study indicate that glutathione therapy could represent a possible therapeutical tool for both of the selected andrological pathologies.
cDNA and deduced amino acid sequence ofDrosophilacatalase (1990)

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The pharmacokinetics of oxcarbazepine and its active metabolite 10‐hydroxy‐carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid (1993)

The kinetics of oxcarbazepine (OXC) and its active metabolite 10-hydroxy-carbazepine (10-OH-CZ) after a single oral OXC dose (600 mg) were compared in healthy control subjects and in epileptic patients treated with phenobarbitone or sodium valproate (n = 8 in each group). In all groups, serum 10-OH-CZ concentrations were much higher than those of the parent drug. In patients on valproate, the kinetics of OXC and 10-OH-CZ did not differ significantly from those observed in controls. In patients on phenobarbitone, AUC values of both OXC and 10-OH-CZ were lower than in controls (2.9 +/- 0.4 vs 5.1 +/- 0.7 microg ml(-1) h and 89 +/- 7 vs 119 +/- 10 microg ml(-1) h respectively, means +/- s.e. mean, P < 0.05), whereas 10-OH-CZ half-lives were only marginally shorter (17 +/- 1 h vs 20 +/- 2 h, NS). These data indicate that the biotransformation of OXC and 10-OH-CZ may be accelerated by concomitant treatment with phenobarbitone but that the magnitude of this effect is unlikely to be of great clinical significance.
Modulation of NMDA Receptor Function by Ketamine and Magnesium: Part I (2001)

Ketamine and Mg2+ inhibit functioning of recombinantly expressed NR1/NR2A and NR1/NR2B glutamate receptors, and combinations of the compounds act in a super-additive manner. These findings may explain, in part, why combinations of ketamine and Mg2+ are more effective analgesics than either compound alone.
Determination of the optimal atrioventricular delay in DDD pacing. Comparison between echo and peak endocardial acceleration measurements (1999)

The goal of this study was to compare two methods determining the optimal atrioventicular delay (AVD) in 19 patients implanted with the BEST-Living system for complete heart block. The definition of the optimal AVD was: the AVD with the echo method that provided the longest diastolic filling time without interruption of the A wave, and the AVD with the peak endocardial acceleration (PEA) method, corresponding to the knee of the PEA curve vs AV delay. The amplitude of the PEA was measured for every AVD programmed via an automatic scanner in steps of 60 to 300 ms (40 ms steps): in the VDD pacing mode with a low base rate, to obtain 100% sensed P waves; in DDD with a base rate = sinus rate + 20%, to obtain 100% paced P waves. Echocardiographic (Echo) measurement of the left ventricular filling time were performed in the same AV delay settings in VDD and DDD as the ones tested in the PEA method, which were manually programmed. The optimal AVDs obtained in DDD and those obtained in VDD were compared in the echo and the PEA tests by a paired Student's t-test. The optimal AVDs obtained by both Echo and by PEA were also compared by a paired Student's t-test in VDD and DDD. The r value of the correlation between the optimal AVDs obtained by Echo and those obtained by PEA was calculated. Similar values of optimal AVD were obtained with both methods. The optimal AVDs given by the Echo technique (179 +/- 25 ms in DDD and 124 +/- 18 ms in VDD) were slightly, but significantly shorter than the ones obtained with the PEA method (202 +/- 21 ms in DDD and 145 +/- 18 ms in VDD, P < 0.05). A highly significant difference between AVD VDD and AVD DDD was found with both methods (P < 0.001). The correlation between the AVDs obtained with the echo and the PEA methods was highly significant (r = 0.78, P < 0.01). Pacemaker software could be modified to determine automatically the optimal AVDs to be applied throughout the heart rate range.
Purification and Characterization of Streptin, a Type A1 Lantibiotic Produced by Streptococcus pyogenes (2003)

Approximately 10% of Streptococcus pyogenes strains inhibit the growth of all nine indicators in a standardized streptococcal bacteriocin typing scheme. The present study has shown that this inhibitory profile, referred to as bacteriocin producer (P)-type 777 activity, is due to the type A1 lantibiotic streptin. Two major forms of streptin were purified to homogeneity from 95% acidified (pH 2) methanol extracts of S. pyogenes M25 cells by using a series of reversed-phase chromatographic separations. The fully processed form of streptin (streptin 1) is a 23-amino-acid peptide with a mass of 2,424 Da. The 2,821-M(r) form of the peptide (streptin 2) has three additional amino acids (TPY) at the N terminus. Strain M25 extracts also contained small quantities of the streptin 1 and streptin 2 peptides in various stages of dehydration. Streptin 1 and streptin 2 were each capable of specifically inducing streptin production when added to strain M25 cultures. The streptin gene cluster resembled that of other type A1 lantibiotics but appeared to lack a streptin-specific proteinase gene. Although the streptin structural gene (srtA) was widespread within S. pyogenes, being detected in 40 of 58 strains, each representing a different M serotype, only 10 of these srtA-positive strains produced active streptin. The failure of some strains to express streptin was attributed to an approximately 4.5-kb deletion in their streptin loci, encompassing genes putatively encoding proteins involved in streptin processing (srtB and srtC) and transport (srtT). In other strains, srtA transcription appeared to be defective. No direct association could be detected between the production of streptin and the production of the lantibiotic-like hemolysin streptolysin S in strain M25.
Practical management of treatment-resistant depression. (1998)

Patients receiving antidepressant monotherapy may be partially or totally resistant to treatment in 10 to 30 percent of cases. In patients who have experienced only partial treatment results, the clinician should first consider optimizing antidepressant dosage or lengthening therapy. Antidepressant drug substitution should generally be reserved for use in patients who haven't responded at all (nonresponders). Combining two or more antidepressants is generally not recommended, as this approach may obscure adequate monotherapy evaluation and lead to significant adverse effects or drug-drug interactions. Use of electroconvulsive therapy is recommended in patients with psychotic and severe refractory depression. Augmentation therapy is often efficacious in patients who exhibit a partial antidepressant response. Lithium and thyroid hormone have been the most extensively studied augmentative agents but, more recently, pindolol and buspirone have also been used for this purpose.
Copper-catalyzed N-Arylation of Aryl Iodides with Benzamides or Nitrogen Heterocycles in the Presence of Ethylenediamine (2002)

The copper-catalyzed N-arylation of benzamides or nitrogen heterocycles was carried out with catalytic CuI (10 mol%) in the presence of ethylenediamine (10 mol%) as a ligand and K3PO4 or Cs2CO3 as a base under mild conditions.
Stationary Features and Cat Detection (2008)

Most discriminative techniques for detecting instances from object categories in still images consist of looping over a partition of a pose space with dedicated binary classifiers. The efficiency of this strategy for a complex pose, i.e., for fine-grained descriptions, can be assessed by measuring the effect of sample size and pose resolution on accuracy and computation. Two conclusions emerge: i) fragmenting the training data, which is inevitable in dealing with high in-class variation, severely reduces accuracy; ii) the computational cost at high resolution is prohibitive due to visiting a massive pose partition. To overcome data-fragmentation we propose a novel framework centered on pose-indexed features which assign a response to a pair consisting of an image and a pose, and are designed to be stationary: the probability distribution of the response is always the same if an object is actually present. Such features allow for efficient, one-shot learning of pose-specific classifiers. \\\\ To avoid expensive scene processing, we arrange these classifiers in a hierarchy based on nested partitions of the pose as in previous work, which allows for efficient search. The hierarchy is then "folded" for training: all the classifiers at each level are derived from one base predictor learned from all the data. The hierarchy is "unfolded" for testing: parsing a scene amounts to examining increasingly finer object descriptions only when there is sufficient evidence for coarser ones. In this way, the detection results are equivalent to an exhaustive search at high resolution. We illustrate these ideas by detecting and localizing cats in highly cluttered greyscale scenes.
Thrombelastographic evaluation of coagulation in transurethral prostatectomy (1996)

These results question the role of systemic fibrinolysis in primary and secondary haemorrhage following TURP and thus the rationale of using antifibrinolytics in these patients. The persistent hypercoagulable state post-operatively indicates a possible role of hypercoagulability in clot retention.
From system F to typed assembly language (1999)

We motivate the design of typed assembly language (TAL) and present a type-preserving ttranslation from Systemn F to TAL. The typed assembly language we pressent is based on a conventional RISC assembly language, but its static type sytem provides support for enforcing high-level language abstratctions, such as closures, tuples, and user-defined abstract data types. The type system ensures that well-typed programs cannot violatet these abstractionsl In addition, the typing constructs admit many low-level compiler optimiztaions. Our translation to TAL is specified as a sequence of type-preserving transformations, including CPS and closure conversion phases; type-correct source programs are mapped to type-correct assembly language. A key contribution is an approach to polymorphic closure conversion that is considerably simpler than previous work. The compiler and typed assembly lanugage provide a fully automatic way to produce certified code, suitable for use in systems where unstrusted and potentially malicious code must be checked for safety before execution.