gebhart/patrepeval huggingface dataset:
Implementation and user-centric comparison of a novel adaptation logic for DASH with SVC (2013)

The MPEG-DASH standard allows the clientcentric access to different representations of video content via the HTTP protocol.The client can flexibly switch between different qualities, i.e., different bit rates and thus avoid waiting times during the video playback due to empty playback buffers.However, quality switches and the playback of lower qualities is perceived by the user which may reduce the Quality of Experience (QoE).Therefore, novel algorithms are required which manage the streaming behavior with respect to the user's requirements and which do not waste network resources.As indicated by recent studies, scalable video coding (SVC) may use the current network and content distribution infrastructure in a more efficient way than with single layer codecs.The contribution of this paper is the design and the implementation of a novel DASH/SVC streaming algorithm.By means of measurements in a test-bed, its performance and benefits are evaluated and compared to existing algorithms from an user-centric view point with objective performance metrics.Our findings show that the proposed algorithm outperforms other DASH mechanisms in terms of video quality, low switching frequency and usage of the available resources in a realistic mobile network scenario.This is a first step towards true QoE management of video streaming in the Internet with DASH and SVC.
Genistein and Daidzein Concentrations and Contents in Seedling Roots of Three Soybean Cultivars Grown under Three Root Zone Temperatures (1998)

Abstract Daidzein and genistein are plant‐to‐bacterium signal compounds involved in soybean nodule formation. They can induce nod gens expression in Bradyrhizobium japonicum. The objective of this study was to determine whether the production of signal molecules was affected by low root zone temperatures (RZTs) in a manner that varied among soybean cultivars. Daidzein and genistein concentrations of soybean seedling roots were measured at three RZTs by high performance liquid chromatography (HPLC). The results indicated that daidzein content and concentration per plant were higher at 15 and 17.5°C than those at 25°C. AC Bravor had higher daidzein contents and concentrations than did Maple Glen and KG20. At 17.5°C. KG20 had higher genistein content and concentration levels than Maple Glen, and no difference existed for the two cultivars at 15 and 25 C. Daidzein contents and concentrations of Maple Glen and AC Bravor increased with harvest time. However, for cultivar KG20, the content and concentration decreased at 19 days after inoculation. Genistein contents and concentrations of the three cultivars increased under each RZT up to the last harvest. There was an interaction between soybean cultivar and RZT for root genistein and daidzein contents and concentrations. The content and concentration of daidzein in soybean seedling roots were much higher (more than five times) than those of genistein.
Viscosity effects on ion-recombination kinetics. Bromocresol green in water-glycerol mixtures (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscosity effects on ion-recombination kinetics. Bromocresol green in water-glycerol mixturesP. Warrick Jr., J. J. Auborn, and Edward M. EyringCite this: J. Phys. Chem. 1972, 76, 8, 1184–1191Publication Date (Print):April 1, 1972Publication History Published online1 May 2002Published inissue 1 April 1972https://pubs.acs.org/doi/10.1021/j100652a017https://doi.org/10.1021/j100652a017research-articleACS PublicationsRequest reuse permissionsArticle Views290Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Translocation of Branched-Chain Arginine Peptides through Cell Membranes:  Flexibility in the Spatial Disposition of Positive Charges in Membrane-Permeable Peptides (2002)

A basic peptide derived from HIV-1 Tat has been reported to have the ability to translocate through cell membranes and to bring exogenous proteins into cells. We have demonstrated that these features could be observed among many arginine-rich peptides, and the presence of a ubiquitous internalization mechanism for arginine-rich oligopeptides has been suggested. In this report, we report that these features are also applicable to the peptides having branched-chain structures. Peptides that have arginine residues on four branched chains (R(n))(4) [n (number of arginine residues)= 0-6] were prepared. Fluorescence microscopic observation revealed that the (R(2))(4) peptide exhibited the most efficient translocation. The dependence on the number of arginine residues of the translocation efficiency and cellular localization was also observed for the branched-chain peptides as was seen in the linear peptides. Quite interestingly, efficient translocation was also recognized in the (RG(3)R)(4) peptide, where three glycine residues intervened between two arginine residues on each chain of (R(2))(4). The results strongly suggested that a linear structure was not indispensable for the translocation of arginine-rich peptides and that there could be considerable flexibility in the location of the arginine residue in the molecules.
Quality Standard for Antimicrobial Prophylaxis in Surgical Procedures (1994)

The Quality Standards Subcommittee of the Clinical Affairs Committee of the Infectious Diseases Society of America (IDSA) developed the standard. The subcommittee was composed of representatives of the IDSA (P.A.G. and J.E.M.), the Society for Hospital Epidemiology of America (R.P.W.), the Surgical Infection Society (E.P.D.), the Pediatric Infectious Diseases Society (P.J.K.), the Centers for Disease Control and Prevention (W.J.M.), the Obstetrics and Gynecology Infectious Diseases Society (R.L.S.), and the Association of Practitioners of Infection Control (T.
Question Answering with Subgraph Embeddings (2014)

This paper presents a system which learns to answer questions on a broad range of topics from a knowledge base using few hand-crafted features. Our model learns low-dimensional embeddings of words and knowledge base constituents; these representations are used to score natural language questions against candidate answers. Training our system using pairs of questions and structured representations of their answers, and pairs of question paraphrases, yields competitive results on a recent benchmark of the literature.
ent-Kaurene Synthase from the FungusPhaeosphaeria sp. L487 (1997)

ent-Kaurene is the first cyclic diterpene intermediate of gibberellin biosynthesis in both plants and fungi. In plants, ent-kaurene is synthesized from geranylgeranyl diphosphate via copalyl diphosphate in a two-step cyclization catalyzed by copalyl diphosphate synthase and ent-kaurene synthase. A cell-free system of the fungus Phaeosphaeria sp. L487 converted labeled geranylgeranyl diphosphate to ent-kaurene. A cDNA fragment, which possibly encodes copalyl diphosphate synthase, was isolated by reverse transcription-polymerase chain reaction using degenerate primers based on the consensus motifs of plant enzymes. Translation of a full-length cDNA sequence isolated from the fungal cDNA library revealed an open reading frame for a 106-kDa polypeptide. The deduced amino acid sequence shared 24 and 21% identity with maize copalyl diphosphate synthase and pumpkin ent-kaurene synthase, respectively. A fusion protein produced by expression of the cDNA in Escherichia coli catalyzed the two-step cyclization of geranylgeranyl diphosphate to ent-kaurene. Amo-1618 completely inhibited the copalyl diphosphate synthase activity of the enzyme at 10(-6) M, whereas it did not inhibit the ent-kaurene synthase activity even at 10(-4) M. These results indicate that the fungus has a bifunctional diterpene cyclase that can convert geranylgeranyl diphosphate into ent-kaurene. They may be separate catalytic sites for the two cyclization reactions.
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration. (1995)

Naturally occurring nucleosides and all anticancer nucleoside analogue drugs are in the beta-D configuration. L-(-)-dioxolane-cytidine [(-)-OddC] is the first L-nucleoside analogue ever shown to have anticancer activity. This compound was converted within cells to its mono-, di-, and triphosphate metabolites and was incorporated into DNA. As with cytosine arabinoside, conversion to the monophosphate was catalyzed by cellular deoxycytidine kinase, which was essential for cytotoxicity. However, unlike cytosine arabinoside, (-)-OddC was not susceptible to degradation by deoxycytidine deaminase. Because (-)-OddC inhibited the growth of hepatocellular and prostate tumors that are generally difficult to treat, it is a promising candidate for additional testing. Our results indicate that there is a great deal of variability in the chiral specificities of cellular enzymes and demonstrate how these differences can be exploited in the design of better anti-viral and anticancer drugs.
Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric ( Curcuma longa ) (2003)

Curcumin has been demonstrated to be safe in six human trials and has demonstrated anti-inflammatory activity. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation.
Breast Cancer: Basic and Clinical Research (2016)

tistically analyzed for significance. RESULTS: Median age at diagnosis was 53 years. With a median follow-up of 46.5 months, there was an 88% overall survival rate. Thirty-seven percent of the patients (p  0.001) were at stages III and IV during diagnosis. The hormone receptor human epidermal receptor negative phenotype ( HR-HER2-) (p  0.001) was present in 17% of the cases. In a multivariate analysis, local (risk ratio, RR: 7.2; confidence interval, CI 95%: 3.8–7.6; p = 0.06) and distant recurrence (RR: 14.9; CI 95%: 7.7–28.9; p = 0.01) showed the strongest association with the probability of death from the disease. Patients with HR-HER2- phenotype tumors reported more local recurrences (p = 0.04), a higher tumor grade (p  0.01), and lower overall survival than patients with other breast cancer phenotypes (p = 0.01). CONCLUSIONS: Although this study analyzes a modest number of cases, it is an initial insight into factors that may contribute to differences in breast cancer outcomes among Hispanic women in Costa Rica. The higher proportion of triple negative tumors, advanced stage, and younger median age at diag nosis could contribute to the inferior prognostic described among Hispanic women. There may be a different distribution of tumor subtypes compared to non-Hispanic white women. Further studies are necessary to confirm such findings.
Quantitation of mRNA by Competitive PCR Using Capillary Electrophoresis (2003)

The high sensitivity of the reverse transcriptase-polymerase chain reaction (RT-PCR) allows the amplification of low abundance mRNA transcripts, but the biomedical research and diagnostics community have increasing interest in the ability to accurately quantify the amounts of mRNA in cell samples. Although theoretically it should be possible to calculate the starting copy number from a consideration of the efficiency of the reverse transcription step of the reaction and the number of PCR cycles performed, it is widely recognized that this approach is flawed and can lead to highly inaccurate results (1).
Enhanced Fluorescence from Fluorophores on Fractal Silver Surfaces (2003)

Recent reports have shown enhanced fluorescence for fluorophores in close proximity to chemically deposited silver islands or colloids. To expand the usefulness of metal-enhanced fluorescence we tested fractal silver structures formed on, or near, silver electrodes by passage of electric currents. The emission intensity of fluorescein-labeled human serum albumin (FITC-HSA) was enhanced over 100-fold when adsorbed to the fractal silver structures as compared to glass. The amplitude-weighted lifetime is dramatically reduced to near 3 ps. Enhanced fluorescence was shown to result in selective observation of FITC-HSA over a fluorophore not attached to the silver surface. And finally, photostability measurements indicate 160-fold more photons are detectable from FITC-HSA on the fractal silver surface. These results suggest the use of in situ generated silver structures for metal-enhanced fluorescence.
A Review of Transcranial Magnetic Stimulation in the in vivo Functional Evaluation of Central Cholinergic Circuits in Dementia (2011)

Central cholinergic circuits of human brain can be tested non-invasively by coupling electrical peripheral stimulation with transcranial magnetic stimulation (TMS) of the motor cortex. The short-latency afferent inhibition (SAI) is reduced in cholinergic forms of dementia, such as Alzheimer disease (AD) and dementia with Lewy bodies, while it is normal in non-cholinergic forms of dementia, such as frontotemporal dementia. This finding suggests that this method can be used as a non-invasive additional tool for discriminating between cholinergic and non-cholinergic forms of dementia. Interestingly, SAI was also found to be significantly smaller in early AD patients. Identification of SAI abnormalities that occur early in the course of AD will allow earlier diagnosis and treatment with cholinergic drugs. In patients with vascular dementia, SAI responses varied widely; the number of patients with abnormal SAI conceivably reflects the percentage of subjects with a significant cholinergic dysfunction. It has recently been demonstrated that brain microbleeds have an impact on SAI that is independent of the extent of associated white matter changes and ischemic stroke. Since SAI can be increased by acetylcholinesterase inhibitors, TMS may help in identifying the patients who would be suitable for long-term treatment with cholinergic agents.
Role of Long‐chain Polyunsaturated Fatty Acids in the First Year of Life (2008)

The 2 most abundant long-chain polyunsaturated fatty acids (LCPUFAs) in the brain are docosahexaenoic acid (DHA) and arachidonic acid (ARA), where they have a functional and structural role in infant development. DHA is concentrated in the prefrontal cortex, which is important for association and short-term memory, and in some retinal cells. Concentrations of PUFAs in human breast milk are relatively consistent during the first year of life, and studies have shown that breast-fed infants have a greater mean weight percentage of DHA and a greater proportion of DHA in their red blood cells and brain cortex than formula-fed infants. Furthermore, cortex DHA in breast-fed infants increases with age, probably due to the length of feeding. Maternal supplementation with cod liver oil, which is rich in DHA and eicosapentaenoic acid, improved children's intelligence quotient compared with corn-oil supplementation by 4 years of age. The LCPUFA content of human breast milk is affected by a number of factors, including diet, gestational age, parity, and smoking. Supplementation of formula feed with DHA and ARA results in infant development that is similar to breast-feeding, and may have benefits on blood pressure in later childhood. The beneficial effects of LCPUFA supplementation on visual acuity continue after weaning irrespective of the type of diet. The long-term effects and duration of supplementation of breast- and formula-fed infants requires further investigation.
A new method for predicting binding affinity in computer-aided drug design (1994)

A new semi-empirical method for calculating free energies of binding from molecular dynamics (MD) simulations is presented. It is based on standard thermodynamic cycles and on a linear approximation of polar and non-polar free energy contributions from the corresponding MD averages. The method is tested on a set of endothiapepsin inhibitors and found to give accurate results both for absolute as well as relative free energies.
Treating Lennox&ndash;Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide (2010)

Lennox-Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamide, a recently approved third-generation AED with reported efficacy as adjunctive therapy for LGS. All relevant papers identified through a PubMed search on the treatment of LGS with rufinamide were reviewed. To date, the literature suggests improvements in seizure frequency for pediatric patients with LGS on rufinamide. Rufinamide appears to be especially effective for atonic or drop attack seizures. Rufinamide also displays a favorable adverse event profile compared with the older anticonvulsants, as well as a minimal number of drug interactions, making it a promising option for the adjunctive treatment of seizures associated with LGS.
TaskTracer (2005)

This paper reports on TaskTracer --- a software system being designed to help highly multitasking knowledge workers rapidly locate, discover, and reuse past processes they used to successfully complete tasks. The system monitors users' interaction with a computer, collects detailed records of users' activities and resources accessed, associates (automatically or with users' assistance) each interaction event with a particular task, enables users to access records of past activities and quickly restore task contexts. We present a novel Publisher-Subscriber architecture for collecting and processing users' activity data, describe several different user interfaces tried with TaskTracer, and discuss the possibility of applying machine learning techniques to recognize/predict users' tasks.
Communication channel equalization using complex-valued minimal radial basis function neural networks (2002)

A complex radial basis function neural network is proposed for equalization of quadrature amplitude modulation (QAM) signals in communication channels. The network utilizes a sequential learning algorithm referred to as complex minimal resource allocation network (CMRAN) and is an extension of the MRAN algorithm originally developed for online learning in real-valued radial basis function (RBF) networks. CMRAN has the ability to grow and prune the (complex) RBF network's hidden neurons to ensure a parsimonious network structure. The performance of the CMRAN equalizer for nonlinear channel equalization problems has been evaluated by comparing it with the functional link artificial neural network (FLANN) equalizer of J.C. Patra et al. (1999) and the Gaussian stochastic gradient (SG) RBF equalizer of I. Cha and S. Kassam (1995). The results clearly show that CMRANs performance is superior in terms of symbol error rates and network complexity.
Opinion Statement of the Effect of Mechanical Stress on Cartilage Tissue Engineering (2010)

Articular cartilage is characterized by its poor capacity for self-repair. Once articular cartilage is injured and defected, it cannot be spontaneously repaired and finally develops osteoarthritis (OA). OA is a major leading cause of severe activity limitations and disability, resulting in worldwide socio-economical burden. At present, there is no established therapy for adequate repair of damaged articular cartilage. Researchers have therefore attempted to establish the cartilage tissue engineering as an effective alternative treatment of cartilage repair. However, the articular cartilage repair still remains a clinical and scientific challenge. In cartilage tissue engineering, it is believed that cell source, scaffold and growth factors are three key factors for the desired result of cell therapy for the damaged cartilage repair. However, increasing evidence is showing that these key factors are not enough and other factors may be required to achieve the optimal outcome. Since normal articular cartilage is always subjected to mechanical stress in daily activities, mechanical stress has attracted much attention as fourth key factor in cartilage tissue engineering. However, the real impact of mechanical stress on cartilage tissue engineering is far from complete understanding. In this review, we summarize the accumulating knowledge of the effect of mechanical stress on cartilage tissue engineering and discuss about the challenges for the future.
Evaluation of a flow cytometric method for simultaneous leukocyte phenotyping and quantification by fluorescent microspheres (1998)

We describe a flow cytometric method using a newly designed product, fluorochrome-containing microspheres (Flow Count fluorospheres), which facilitates the precise quantification of cells in whole blood samples or heterogeneous cell suspensions on a single-cell level. These microparticles are easily distinguishable from other events of interest and can be detected by their light-scattering and fluorescence properties. In contrast to the traditional manual or automated cell-counting techniques, this method offers the opportunity to quantify cells simultaneously with flow cytometric immunophenotyping without additional cell loss or other cell preparation steps. We evaluated the accuracy and reproducibility of this flow cytometric method on the determination of CD45+ leukocyte counts and compared the results with those obtained by conventional techniques. Particular interest was focused on the behavior of cells and fluorospheres regarding their sedimentation rate over the period of analysis. The data from 48 blood samples with low, normal, and high leukocyte counts confirmed the reliability and comparability of the flow cytometric method, permitting the determination of white blood cell concentration at least to a limit of 100 cells/microL. A broad field of applications will benefit from this flow cytometric supplement because it is easy to perform and highly accurate. The results appear to be transferable to clinical decision-making monitoring of CD4+ lymphocytes in patients infected with human immunodeficiency virus or of CD34+ hematopoietic cells, optimizing the harvest for peripheral blood stem cell transplantation.
A novel approach to modeling and diagnosing the cardiovascular system (1995)

A novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.