gebhart/patrepeval huggingface dataset:
HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy (2002)

Different mechanisms mediated by the expression of the HLA-class Ib HLA-G products are suggested to account for the induction of immune tolerance against the paternal antigens of the fetus during pregnancy. Soluble HLA-G antigens, mainly produced by cytotrophoblast cells at the materno-fetal interface and circulating in the body fluids, show a capacity analogous to that of membrane-boundstructures to inhibit NK cells. In the present report we have investigated, using specific ELISA, the presence of sHLA-G molecules in culture supernatants of early embryos obtained by in vitro fertilization (IVF) before transfer. The data obtained from the analysis of 285 supernatants corresponding to 101 IVF procedures (43 IVF, 58 intracytoplasmic sperm injection) identify two groups of patients on the basis of sHLA-G antigen presence. No differences in clinical parameters were observed between the groups, but positive embryo implantations occurred only in women showing sHLA-G molecules in culture supernatants (Fisher's exact p value 2.56 x 10(-3)). The results obtained indicate that expression of HLA-G products in embryo cells is a mandatory, but not sufficient, prerequisite for the development of pregnancy.
Dynamics of Biomineral Formation at the Near-Molecular Level (2008)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTDynamics of Biomineral Formation at the Near-Molecular LevelS. Roger Qiu and Christine A. Orme*View Author Information Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Mailstop L-367, Livermore, California 94550Cite this: Chem. Rev. 2008, 108, 11, 4784–4822Publication Date (Web):November 12, 2008Publication History Received24 April 2008Published online12 November 2008Published inissue 12 November 2008https://pubs.acs.org/doi/10.1021/cr800322uhttps://doi.org/10.1021/cr800322ureview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views3241Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Crystallization,Crystals,Kinetics,Scanning probe microscopy,Supersaturation Get e-Alerts
Selective O2 Sorption at Ambient Temperatures via Node Distortions in Sc-MIL-100 (2016)

An open pored metal–organic framework (MOF) with oxygen selectivity at exceptionally high temperatures is confirmed by synthesis, sorption, and synchrotron structural analyses. The large-pore MIL-100 framework with access to the metal center (e.g., Sc and Fe) resulted in preferential O2 over N2 gas uptake at temperatures ranging from 77 K to ambient temperatures (258, 298, and 313 K). Most notably, Sc-MIL-100 shows exceptional O2 sorption; pair distribution function analyses indicate that this is due to distortions in the framework owing to the size of Sc atoms, in particular in the trimer metal cluster. Experimental studies also correlate very well with GCMC simulations, confirming more favorable O2-framework interactions at pressures up to 1 bar, due to the close proximity of O2 to the high density of metal centers in the small tetrahedral cages. Both materials maintain their crystallinity upon gas adsorption cycling, are regenerable, and show exceptional promise for use in energy efficient oxygen purification processes, such as Pressure Swing Adsorption.
Sensitive fluorescencein situhybridization signal detection in maize using directly labeled probes produced by high concentration DNA polymerase nick translation (2006)

The signal produced by fluorescence in situ hybridization (FISH) often is inconsistent among cells and sensitivity is low. Small DNA targets on the chromatin are difficult to detect. We report here an improved nick translation procedure for Texas red and Alexa Fluor 488 direct labeling of FISH probes. Brighter probes can be obtained by adding excess DNA polymerase I. Using such probes, a 30 kb yeast transgene, and the rp1, rp3 and zein multigene clusters were clearly detected.
Automatic Instruction-Level Software-Only Recovery (2006)

As chip densities and clock rates increase, processors are becoming more susceptible to transient faults that can affect program correctness. Computer architects have typically addressed reliability issues by adding redundant hardware, but these techniques are often too expensive to be used widely. Software-only reliability techniques have shown promise in their ability to protect against soft-errors without any hardware overhead. However, existing low-level software-only fault tolerance techniques have only addressed the problem of detecting faults, leaving recovery largely unaddressed. In this paper, we present the concept, implementation, and evaluation of automatic, instruction-level, software-only recovery techniques, as well as various specific techniques representing different trade-offs between reliability and performance. Our evaluation shows that these techniques fulfill the promises of instruction-level, software-only fault tolerance by offering a wide range of flexible recovery options
New applications of gemcitabine and future directions in the management of pancreatic cancer (2002)

Gemcitabine has been reported to be an active agent in pancreatic cancer. Recent applications have included the use of a fixed-dose rate regimen in patients with advanced pancreatic cancer based on the observation that deoxycytidine kinase is saturated at the plasma gemcitabine concentrations achieved with standard infusion, thereby limiting the accumulation of intracellular gemcitabine triphosphate. In a Phase II study, this regimen was associated with survival rates better than those typically observed in patients with advanced disease. Gemcitabine also has been assessed as a radiosensitizer in locally advanced cancer and although toxicity was significant, objective responses were observed and included tumor response, which permitted curative resection. Future directions in therapy for pancreatic cancer include the development of agents targeting signal transduction pathways and nuclear transcription factors based on the continually improving understanding of the role of molecular events in carcinogenesis.
Bladder voiding by combined high frequency electrical pudendal nerve block and sacral root stimulation (2007)

These results demonstrate that bilateral HFAC block of the PN can produce effective voiding. Neural prostheses using this approach may provide an alternative method for producing micturition for people with spinal cord injury.
Adult T-cell leukemia: clinical and hematologic features of 16 cases (1977)

Clinical and hematologic studies of 16 adult patients whose leukemic cells had T-cell markers are reported from Japan, where the incidence of various lymphoproliferative diseases differs considerably from that in Western countries. Leukemic cells were studied by cytotoxicity tests with specific antisera against human T (ATS) and B cells (ABS) in addition to the usual T- and B-cell markers (E rosette, EAC rosette, and surface immunoglobulins). Characteristics of the clinical and hematologic findings were as follows: (1) onset in adulthood; (2) subacute or chronic leukemia with rapidly progressive terminal course; (3) leukemic cells killed by ATS and forming E rosettes; (4) leukemic cells not morphologically monotonous and frequent cells with deeply indented or lobulated nuclei; (5) frequent skin involvement (9 patients); (6) common lymphadenopathy and hepatosplenomegaly; (7) no mediastinal mass; and, the most striking finding, (8) the clustering of the patients’ birthplaces, namely, 13 patients born in Kyushu. The relationship between our cases and other subacute or chronic adult T-cell malignancies such as chronic lymphocytic leukemia of T-cell origin, prolymphocytic leukemia with T-cell properties, Sezary syndrome, and mycosis fungoides is discussed.
Highly Efficient Route to Synthesis Of Complex Alkaloids Developed (1989)

RETURN TO ISSUEPREVNewsNEXTHighly Efficient Route to Synthesis Of Complex Alkaloids DevelopedBerkeley scientists use polycyclization reaction that may mimic biosynthesis to achieve total synthesis of Daphniphyllum alkaloidsRUDY BAUMCite this: Chem. Eng. News 1989, 67, 8, 22–23Publication Date (Print):February 20, 1989Publication History Published online10 November 2010Published inissue 20 February 1989https://pubs.acs.org/doi/10.1021/cen-v067n008.p022https://doi.org/10.1021/cen-v067n008.p022newsACS PublicationsCopyright © 1989 AMERICAN CHEMICAL SOCIETYArticle Views17Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Organic compounds Get e-Alerts
Multiple breakpoints within the BCL-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene. (1993)

Centrocytic lymphoma (CC) and intermediately differentiated lymphocytic lymphoma (IDL) are B-cell non-Hodgkin's lymphomas composed of lymphocytes presumably derived from follicle mantle cells. In these lymphomas, a specific chromosomal translocation, t(11;14)(q13;q32), has been described. Previous studies suggested an association between t(11;14) chromosomal translocations and BCL-1 rearrangements. To evaluate the association between BCL-1 rearrangements and CC/IDL, Southern blot analysis was performed on a panel of 20 cases of CC/IDL, 22 cases of morphologically similar non-Hodgkin's lymphomas, 11 cases of chronic B-cell leukemias, and 2 cases of myelomas. We used various probes covering a considerable proportion of the 120-kilobase BCL-1 locus, and rearrangements in 50% of CC/IDL (10 of 20) were detected. In CC, all 4 breakpoints were located at the major translocation cluster (MTC). In contrast, in IDL, rearrangements were detected in 3 different cluster regions: 2 cases in the MTC, 2 cases with a breakpoint 24 kilobases outside the MTC, and 2 additional cases with breakpoints found 3 kilobases 5' of the first exon of the PRAD1/CCND1 gene, which is located 120 kilobases outside the MTC. In addition, one leukemia showed a breakpoint 63 kilobases outside the MTC. In all cases, there was comigration of the rearranged 11q13 fragment and the immunoglobulin heavy chain-joining gene complex, indicating a t(11;14)(q13;q32) chromosomal rearrangement. Our results show that Southern blot analysis is helpful to identify CC/IDL, but multiple breakpoints are present over a large region, and therefore, many probes are necessary to cover all breakpoints.
Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans (2008)

Results from our study provide the first confirmation of these 17q SNPs as novel prostate cancer susceptibility loci in EA and the first indication that these two loci may also play roles in prostate cancer risk among AA.
RNA Ligases (2008)

T4 RNA ligase 1 catalyzes the ATP-dependent covalent joining of single-stranded 5'-phosphoryl termini of DNA or RNA to single-stranded 3'-hydroxyl termini of DNA or RNA. T4 RNA ligase 2 also catalyzes the joining of a 3'-hydroxyl terminus of RNA to a 5'-phosphorylated RNA or DNA; unlike T4 RNA ligase 1, this enzyme prefers double-stranded substrates. A truncated form of T4 RNA ligase 2 requires a pre-adenylated substrate for ligation. This unit describes specific reaction conditions, as well as applications such as radioactive labeling of the 3' termini of RNA, circularizing oligodeoxyribonucleotides and oligoribonucleotides, ligating oligomers and nicks, creating hybrid and chimeric DNA/RNA molecules, and miRNA cloning.
Using a Mobile Device “App” and Proximal Remote Sensing Technologies to Assess Soil Cover Fractions on Agricultural Fields (2018)

Quantifying the amount of crop residue left in the field after harvest is a key issue for sustainability. Conventional assessment approaches (e.g., line-transect) are labor intensive, time-consuming and costly. Many proximal remote sensing devices and systems have been developed for agricultural applications such as cover crop and residue mapping. For instance, current mobile devices (smartphones &amp; tablets) are usually equipped with digital cameras and global positioning systems and use applications (apps) for in-field data collection and analysis. In this study, we assess the feasibility and strength of a mobile device app developed to estimate crop residue cover. The performance of this novel technique (from here on referred to as "app" method) was compared against two point counting approaches: an established digital photograph-grid method and a new automated residue counting script developed in MATLAB at the University of Guelph. Both photograph-grid and script methods were used to count residue under 100 grid points. Residue percent cover was estimated using the app, script and photograph-grid methods on 54 vertical digital photographs (images of the ground taken from above at a height of 1.5 m) collected from eighteen fields (9 corn and 9 soybean, 3 samples each) located in southern Ontario. Results showed that residue estimates from the app method were in good agreement with those obtained from both photograph-grid and script methods (R² = 0.86 and 0.84, respectively). This study has found that the app underestimates the residue coverage by -6.3% and -10.8% when compared to the photograph-grid and script methods, respectively. With regards to residue type, soybean has a slightly lower bias than corn (i.e., -5.3% vs. -7.4%). For photos with residue <30%, the app derived residue measurements are within ±5% difference (bias) of both photograph-grid- and script-derived residue measurements. These methods could therefore be used to track the recommended minimum soil residue cover of 30%, implemented to reduce farmland topsoil and nutrient losses that impact water quality. Overall, the app method was found to be a good alternative to the point counting methods, which are more time-consuming.
Design of adaptive load shedding by artificial neural networks (2005)

The design of an adaptive load-shedding strategy by executing an artificial neural network (ANN) and transient stability analysis for an electric utility system is presented. To prepare the training data set for an ANN, the transient stability analysis of an actual power system has been performed to solve for minimum load shedding with various operation scenarios without causing the tripping problem of generators. The Levenberg–Marquardt algorithm has been adopted and incorporated into the back-propagation learning algorithm for training feedforward neural networks. By selecting the total power generation, total load demand and frequency decay rate as the input neurons of the ANN, the minimum amount of load shedding is determined to maintain the stability of power systems. To demonstrate the effectiveness of the proposed ANN minimum load-shedding scheme, a utility power system has been selected for computer simulation and the amount of load shedding is verified by stability analysis.
Corrosion Inhibitors for Hot Acid Media (2004)

Abstract The available literature on corrosion inhibitors for application in hot acid solutions including both organic and mineral acids has been reviewed. The authors have synthesized a few organic compounds and investigated their corrosion inhibiting characteristics. The salient features obtained from weight loss, potentiodynamic polarization and hydrogen permeation have been discussed. The difference in inhibition action has been explained on the basis of their molecular structures.
Genetic characteristics of new recA mutants of Escherichia coli K-12 (1996)

To search for functionally thermosensitive (FT) recA mutations, as well as mutations with differently affect RecA protein functions, seven new recA mutations in three different regions of the RecA protein structure proposed by Story et al. [R. M. Story, I. T. Weber, and T. A. Steitz, Nature (London) 355:318-325, 1992] were constructed. Additionally, the recA2283 allele responsible for the FT phenotype of the recA200 mutant was sequenced. Five single mutations (recA2277, recA2278, recA2283, recA2283E, and recA2284) and one double mutation (recA2278-5) generated, respectively, the amino acid substitutions L-277-->N, G-278-->P, L-283-->P, L-283-->E, I-284-->D, and G-278-->T plus V-275-->F in the alpha-helix H-beta-strand 9 region of the C-terminal domain of the RecA protein structure. According to recombination, repair, and SOS-inducible characteristics, these six mutations fall into four phenotypic classes: (i) an FT class, with either inhibition of all three analyzed functions at 42 degrees C (recA2283), preferable inhibition at 42 degrees C of recombination and the SOS response (recA2278), or inhibition at 42 degrees C of only recombination (recA2278-5); (ii) a moderately deficient class (recA2277); (iii) a nondeficient class (recA2283E); and (iv) a mutation with a null phenotype (recA2284). The recA2223 mutation generates an L-223-->M substitution in beta-strand 6 in a central domain of the RecA structure. This FT mutation shows preferable inhibition of the SOS response at 42 degrees C. The recA2183 mutation produces a K-183-->M substitution in alpha-helix F of the same domain. The Lys-183 position in the Escherichia coli RecA protein was found among positions which are important for interfilament interaction (R. M. Story, I. T. Weber, and T. A. Steitz, Nature (London) 355:318-325, 1992).
Higher response to lenalidomide in relapsed/refractory diffuse large B‐cell lymphoma in nongerminal center B‐cell–like than in germinal center B‐cell–like phenotype (2011)

The data suggest that the 2 major subgroups of patients with DLBCL (germinal center B cell and nongerminal center B cell) have different antitumor responsiveness to lenalidomide in the relapsed/refractory setting. A large international trial (NCT01197560) has been opened to enrollment in an attempt to prospectively validate these retrospective observations.
Relative Importance of Proteinase-Activated Receptor-1 Versus Matrix Metalloproteinases in Intracerebral Hemorrhage-Mediated Neurotoxicity in Mice (2009)

The neurotoxicity of blood in intracerebral hemorrhage involves both proteinase activated receptor-1 and MMP activation, with the latter appearing more prominent in causing death.
Activation of Toll-like Receptor 4 on Tumor Cells In vitro Inhibits Subsequent Tumor Growth In vivo (2007)

Although an eruption of information on the role of Toll-like receptor 4 (TLR4), the main receptor for bacterial lipopolysaccharide, in activating macrophages and dendritic cells has emerged, very little is known about the role of TLR4 present on epithelial cells from sterile environments like tumors. The main goal of this work was to investigate the consequences of TLR4 activation present on tumor cells in two different animal models of cancer: the Dunning rat prostate cancer and the B16 murine melanoma models. We show that (a) activating TLR4 signaling in two different tumor cell lines in vitro modifies the tumor outgrowth in vivo; (b) this effect is not due to a direct consequence of TLR4 signaling on the proliferation/apoptosis balance of the tumor cells; (c) the T-cell compartment is somehow involved in the described phenomenon because the inhibitory effect observed is not seen in athymic nude mice; and (d) tumor-infiltrating lymphocytes purified from tumors induced by TLR4-activated cells show strong induction of IFN gamma transcript in detriment of interleukin-10 transcript, suggesting a change in their functionality. We hypothesize that TLR4 signaling in tumor cells in vitro induces the expression of proinflammatory mediators, which could dramatically alter the maturation state of dendritic cells present at the site of inoculation, switching the type of immune response elicited against the tumor. These results open up new avenues for understanding the role of TLR4 in tumor cells and for identifying potential new therapy strategies for cancer.
Rapid Automated Algorithm for Aligning and Reslicing PET Images (1992)

A computer algorithm for the three-dimensional (3D) alignment of PET images is described. To align two images, the algorithm calculates the ratio of one image to the other on a voxel-by-voxel basis and then iteratively moves the images relative to one another to minimize the variance of this ratio across voxels. Since the method relies on anatomic information in the images rather than on external fiducial markers, it can be applied retrospectively. Validation studies using a 3D brain phantom show that the algorithm aligns images acquired at a wide variety of positions with maximum positional errors that are usually less than the width of a voxel (1.745 mm). Simulated cortical activation sites do not interfere with alignment. Global errors in quantitation from realignment are <2%. Regional errors due to partial volume effects are largest when the gantry is rotated by large angles or when the bed is translated axially by one-half the interplane distance. To minimize such partial volume effects, the algorithm can be used prospectively, during acquisition, to reposition the scanner gantry and bed to match an earlier study. Computation requires 3–6 min on a Sun SPARCstation 2.
Development of Auto immunity in MRL/Ipr Mice and the Effects of Drugs on this Murine Disease (1988)

MRL/lpr mice spontaneously develop a systemic Lupus erythematosus (SLE)-like disease with a wide range of clinical and serological characteristics that mimic not only human SLE but other autoimmune disorders. such as Sjögren's syndrome, and rheumatoid arthritis (RA). Unlike other murine SLE-like disorders, these mice have circulating rheumatoid factor (RF) and develop histological changes in their joints. Therapy of this disease with cyclophosphamide (CY), cyclosporin A, prednisolone, or leflunomide (HWA 486) resulted in very differing effects. Treating these mice with HWA 486 or cyclophosphamide (CY) resulted in a decrease in the amount of autoantibodies, and immune complex deposits on the glomeruli. HWA 486 therapy led to restoration of the depressed immune response of MRL/lpr mice. In the established disease, prednisolone (Pr), cyclosporin A (CSA), and HWA 486 could inhibit the proteinuria and return the urine-protein values to normal levels, but, unlike HWA 486, neither PR nor CSA could extend the longevity of these animals. The MRL/lpr mouse should prove to be very useful as a model for SLE, RA, and for discovering novel drugs to combat such disorders.