gebhart/patrepeval huggingface dataset:
Improving virtual machine performance using a cross-run profile repository (2005)

Virtual machines for languages such as the Java programming language make extensive use of online profiling and dynamic optimization to improve program performance. But despite the important role that profiling plays in achieving high performance, current virtual machines discard a program's profile data at the end of execution, wasting the opportunity to use past knowledge to improve future performance. In this paper, we present a fully automated architecture for exploiting cross-run profile data in virtual machines. Our work addresses a number of challenges that previously limited the practicality of such an approach.We apply this architecture to address the problem of selective optimization , and describe our implementation in IBM's J9 Java virtual machine. Our results demonstrate substantial performance improvements on a broad suite of Java programs, with the average performance ranging from 8.8% -- 16.6% depending on the execution scenario.
1550 nm polarization independent DBR gain clamped SOA with high dynamic input power range (1996)

A polarization independent monolithically integrated gain-clamped SOA for 1.55 /spl mu/m in a DBR configuration, with double-core spot-size converter and tensile bulk material is reported. Gain saturation remains below 0.5 dB up to +12 dBm output power.
Conversion of Oilfield Produced Water Into an Irrigation/Drinking Quality Water (1993)

ABSTRACT A process has been developed for converting oilfield produced water into irrigation/drinking quality water. The process consists of air flotation, clarification, softening, filtration, reverse osmosis and water reconditioning. A pilot plant was successfully operated for a extended period of time for handling water with approximately 7,000 mg/L of total dissolved solids, 250 mg/L silica and 170 mg/L soluble oil at a wide range of pH (7-11). The quality of treated water met the stringent California Title 22 Drinking Water Maximum Contaminant Levels.
[Retinal tissue damage and lipid peroxidation in experimental autoimmune uveoretinitis]. (1991)

Retinal lipid peroxidation products were measured at various stages of experimental autoimmune uveoretinitis (EAU) induced in Lewis rats by retinal S-antigen. Histopathologic examination and measurement of myeloperoxidase, which is a quantitative marker of polymorphonuclear leukocytes (PMNs) in tissue, were also performed. The results showed that lipid peroxidation is closely implicated in the progression of uveoretinitis, and is related to the cellular infiltrate, which consisted primarily of PMNs, and to the retinal tissue damage. These findings may support the theory that oxygen-free radicals liberated from activated PMNs play a role in retinal tissue damage via peroxidation of membrane lipids. To ascertain the tissue damage caused by the lipid peroxidation products generated in the eye, intravitreal injection of an oxidized docosahexaenoic acid, a major polyunsaturated fatty acid in the photoreceptors of the retina, was performed and its toxicity in the retina was proved histologically.
CD40 plays an essential role in the activation of human B cells by murine EL4B5 cells. (1993)

A mutant subclone of the murine thymoma EL-4, known as EL4B5, can strongly activate human B cells to proliferate and differentiate in a cell-cell contact-dependent manner. We have investigated whether interaction via CD40 plays a role in this helper activity. For this purpose, three newly generated anti-CD40 monoclonal antibodies (mAb) were used. In contrast with other anti-CD40 mAb described in the literature, these mAb did not co-stimulate proliferation of human B cells. On the other hand, these novel mAb could inhibit the co-stimulatory effect of the previously described anti-CD40 mAb S2C6 on anti-IgM-induced human B-cell proliferation. It was found that addition of these non-stimulatory anti-CD40 mAb could completely inhibit EL4B5-induced human B-cell proliferation. Maximal inhibition occurred already at a mAb concentration of 10 ng/ml. Similarly, a fusion protein, consisting of the extracellular portion of CD40 and human IgM constant domains CH2, CH3 and CH4, could completely inhibit EL4B5-induced human B-cell proliferation. Induction of human B-cell proliferation by EL4B5 cells was also inhibited by anti-CD40 mAb S2C6 and G28.5, but less effectively. In contrast, mAb against B-cell surface antigens CD20 or B7 had no inhibitory effects. It is concluded that interaction via CD40 is essential for the induction of human B-cell proliferation by EL4B5 cells.
Nonclinical Safety Evaluation of a Transforming Growth Factor β Receptor I Kinase Inhibitor in Fischer 344 Rats and Beagle Dogs (2014)

Abstract 
Objective: The transforming growth factor β (TGF-β) pathway regulates diverse cellular functions and plays a prominent role in diseases such as cancer, autoimmune disorders and cardiovascular disease. LY2157299 monohydrate (LY2157299) is a potent and selective inhibitor of TGF-β receptor I kinase that is under clinical evaluation for the treatment of advanced cancer. 
Methods: This paper characterizes the toxicity profile of LY2157299 in Fischer 344 rats and beagle dogs for up to six months of daily oral dosing. LY2157299 is well tolerated in the rat and dog for up to one month of daily dosing at doses of 150 and 20 mg/kg, respectively. 
Results: In the rat, LY2157299 is well tolerated after three months of 2 weeks on/2 weeks off intermittent dosing schedule at 50 mg/kg. Chronic (≥3 months) oral administration results in multiple target organ toxicities involving the cardiovascular, gastrointestinal, immune, bone/cartilage, reproductive, and renal systems. 
Conclusion: Defining the appropriate dose and schedule led to a better understanding of how to define safety margins and thus enable the clinical investigation of LY2157299 in cancer patients.
Quantum-correlated twin photons from microstructure fiber (2004)

We present a source of correlated photon pairs that relies on spontaneous parametric scattering in microstructure fiber. Quantum correlations are shown between photon pairs that are generated through four-photon scattering where the pump photons are degenerate at a wavelength of 749 nm and the signal and idler photons are nondegenerate at wavelengths of 761 nm and 737 nm, respectively. Careful adjustment of the pump wavelength and polarization are shown to be critical to observing quantum correlations.
Experimental Study of Kilowatt-Average-Power Faraday Isolators (2007)

We designed two 20mm-aperture Faraday isolators with thermal effects compensation. The isolation ratio (limited by the quality of TGG crystals) was 24dB at 750W average power for one isolator and 42dB at 200W for another.
Ligand-Based Reduction of CO2 and Release of CO on Iron(II) (2012)

A synthetic cycle for the CO(2)-to-CO conversion (with subsequent release of CO) based on iron(II), a redox-active pydridinediimine ligand (PDI), and an O-atom acceptor is reported. This conversion is a passive-type ligand-based reduction, where the electrons for the CO(2) conversion are supplied by the reduced PDI ligand and the ferrous state of the iron is conserved.
Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution (1994)

Formation of 2-bromoacrolein (2BA) from tris(2,3-dibromopropyl)phosphate (Tris-BP) by cytochrome P450 (cyt. P450) activity is most likely responsible for the high mutagenicity of Tris-BP for bacteria in vitro when rat liver microsomes are used for metabolic activation. As yet, it has not been established whether cyt. P450 plays a role in the formation of genotoxic metabolites from Tris-BP in higher organisms in vivo. This was studied by comparing the effects of completely deuterated Tris-BP (D15-Tris-BP) with normal Tris-BP in various in vivo test systems for genotoxicity: deuterium substitution should decrease cyt. P450-dependent bioactivation of Tris-BP. Three test systems in Drosophila were used to measure different types of genetic damage: (I) the ring-X chromosome loss (CL) test to detect clastogenicity, (II) the sex-linked recessive lethal (RL) test to detect forward mutations and deletions and (III) the white/white+ (w/w+) eye mosaic assay to detect predominantly mitotic recombination. Tris-BP was positive in all test systems, while D15-Tris-BP was without effect. The relative clastogenic efficiency of a compound, defined as the ratio of CL over RL, can be used to distinguish monofunctional agents (CL/RL ratio < or = 1) from those having cross-linking potential (CL/RL ratio > 2). The CL/RL ratio of Tris-BP was 2.4, indicating that Tris-BP has cross-linking potential. No CL/RL ratio for D15-Tris-BP could be determined, because it was negative in both tests. The putative Tris-BP metabolite 2BA was also tested in the Drosophila test systems. 2BA was positive in the CL test at a high dose, but it showed no response in the RL test. The relative clastogenic efficiency (the ratio of CL/RL) could not be determined accurately, but the data nevertheless argue in favour of cross-linking properties of 2BA. Further, 2BA was clearly positive in the w/w+ eye mosaic test system, which indicates that it is a recombinagen. Genotoxicity of Tris-BP in rats was determined by the induction of micronuclei in hepatocytes. Tris-BP administered intraperitoneally 17 h after 2/3 partial hepatectomy (PH), induced a high frequency of micronuclei at days 2 and 3 after injection (26% and 22%, respectively). D15-Tris-BP, however did not increase the micronuclei frequency.(ABSTRACT TRUNCATED AT 400 WORDS)
Safety of pulsed electric devices (2008)

The strength-duration curve for tissue excitation can be modeled by a parallel resistor-capacitor circuit that has a time constant. We tested several short-duration electric generators: five electric fence energizers, the Taser X26 and a high-frequency generator to determine their current-versus-time waveforms. We estimated their safety characteristics using existing IEC and UL standards for electric fence energizers. The current standards are difficult to follow, with cumbersome calculations, and do not explicitly explain the physiological relevance of the calculated parameters. Hence we propose a new standard. The proposed new standard would consist of a physical RC circuit with a certain time constant. The investigator would discharge the device into a passive resistor-capacitor circuit and measure the resulting maximum voltage. If the maximum voltage does not exceed a limit, the device passes the test.
Adsorption of Trinitrotoluene on Uncoated Silicon Microcantilever Surfaces (2004)

We measured the adsorption characteristics of trinitrotoluene (TNT) on piezoresistive silicon microcantilever surfaces under ambient air using a well-characterized TNT vapor generator. This allowed us to quantify the adsorption parameters and to estimate the sticking coefficient. The sticking coefficient initially increases with TNT exposure time and then levels off around 0.3. Atomic force microscopy images of silicon surfaces exposed to TNT revealed "island" formation of the adsorbate on the silicon surface. At low exposure times, mainly the number density of islands increased with exposure time; at longer exposure times, the size (in particular, height) of the islands grew, corresponding to the higher sticking coefficients. These observations can be qualitatively explained via the difference between TNT-surface and TNT-TNT interactions mediated by water molecules.
Pluggable Single-Mode Fiber-Array-to-PIC Coupling Using Micro-Lenses (2017)

Single-mode optical coupling between fiber and photonic integrated circuit (PIC) requires precision alignment and bonding, and significantly adds to the cost of photonic packaging. This article describes how a pair of micro-lens arrays—one on the Si-PIC and the other on the fiber-array—can be used to achieve fiber-to-PIC grating-coupling with an insertion-loss of 1.7 dB (i.e., a coupling efficiency of 68%) at 1300 nm, and a 1 dB alignment tolerance of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\pm ~30~\mu \text{m}$ </tex-math></inline-formula> . Such relaxed tolerances allow for a “pluggable” connector to have a make-break insertion-loss reproducibility of 0.2 dB (one standard deviation).
Vacuum-Assisted Closure Therapy: A New Treatment Option for Recurrent Pilonidal Sinus Disease. Report of Three Cases (2004)

No single treatment option available for symptomatic pilonidal disease is entirely satisfactory. In our department, we have treated successfully three cases of pilonidal disease with vacuum-assisted closure therapy. We describe our initial experience with this technique. In two cases, the pilonidal sinus was primarily excised, a split skin graft applied to cover the defect, and the vacuum-assisted closure pump applied over the skin graft for a period of four days on a continuous negative pressure of 50 mmHg. The third case was treated and completely healed with vacuum-assisted closure therapy alone. To our knowledge, this is the first report in the literature describing the use of vacuum-assisted closure therapy for this condition. We propose this therapy as an alternative adjunctive treatment for pilonidal disease.
LLysine αOxidase: Physicochemical and Biological Properties (2002)

This review summarizes data on the properties of Llysine α�oxidase, an enzyme that belongs to the group of oxi� dases of Lamino acids. This enzyme acts virtually only on Llysine with a rather low Km yielding α�keto� e�aminocaproic acid. The decrease in the level of the essential amino acid Llysine and the formation of hydrogen peroxide during the reac� tion possibly provide the basis for the unique properties of Llysine α�oxidase: cytotoxic, antitumor, antimetastatic, antiin� vasive, antibacterial, and antiviral activities, as well as an immunomodulating effect. Native Llysine α�oxidase and its immo� bilized forms are promising tools for determination of concentration of Llysine in various biological materials.
Temporal sequence of changes to the gray squirrel retina after near-UV exposure. (1989)

Monocularly aphakic gray squirrels (Sciurus carolinensis) were exposed for 10 min to monochromatic near-ultraviolet radiation (lambda = 366 nm, radiant exposure = 4.3 J/cm2) to determine if their yellow pigmented lens protected retinal tissue from photochemical damage. Eyes were examined from 1 to 30 days after exposure to determine the temporal sequence of retinal damage and the extent of recovery from such exposures. Light microscopy of exposed aphakic retinas revealed irreversible lesions to the photoreceptors. Swelling of inner segments, accumulation of heavy pigment deposits in the PE, presence of macrophages in the subretinal space, and pyknosis of photoreceptor nuclei were observed in the exposed region of the aphakic eye. Eyes exposed to ultraviolet radiation with their lenses intact were devoid of significant retinal lesions. This study represents a model system for studying the potential damaging effects of near-UV radiation to the aphakic eyes of humans.
Comparative Pulmonary Toxicity Assessment of Single-wall Carbon Nanotubes in Rats (2003)

The aim of this study was to evaluate the acute lung toxicity of intratracheally instilled single-wall carbon nanotubes (SWCNT) in rats. The lungs of rats were instilled either with 1 or 5 mg/kg of the following control or particle types: (1) SWCNT, (2) quartz particles (positive control), (3) carbonyl iron particles (negative control), (4) phosphate-buffered saline (PBS) + 1% Tween 80, or (5) graphite particles (lung tissue studies only). Following exposures, the lungs of PBS and particle-exposed rats were assessed using bronchoalveolar lavage (BAL) fluid biomarkers and cell proliferation methods, and by histopathological evaluation of lung tissue at 24 h, 1 week, 1 month, and 3 months postinstillation. Exposures to high-dose (5 mg/kg) SWCNT produced mortality in ~15% of the SWCNT-instilled rats within 24 h postinstillation. This mortality resulted from mechanical blockage of the upper airways by the instillate and was not due to inherent pulmonary toxicity of the instilled SWCNT particulate. Exposures to quartz particles produced significant increases versus controls in pulmonary inflammation, cytotoxicity, and lung cell parenchymal cell proliferation indices. Exposures to SWCNT produced transient inflammatory and cell injury effects. Results from the lung histopathology component of the study indicated that pulmonary exposures to quartz particles (5 mg/kg) produced dose-dependent inflammatory responses, concomitant with foamy alveolar macrophage accumulation and lung tissue thickening at the sites of normal particle deposition. Pulmonary exposures to carbonyl iron or graphite particles produced no significant adverse effects. Pulmonary exposures to SWCNT in rats produced a non-dose-dependent series of multifocal granulomas, which were evidence of a foreign tissue body reaction and were nonuniform in distribution and not progressive beyond 1 month postexposure (pe). The observation of SWCNT-induced multifocal granulomas is inconsistent with the following: (1) lack of lung toxicity by assessing lavage parameters, (2) lack of lung toxicity by measuring cell proliferation parameters, (3) an apparent lack of a dose response relationship, (4) nonuniform distribution of lesions, (5) the paradigm of dust-related lung toxicity effects, (6) possible regression of effects over time. In addition, the results of two recent exposure assessment studies indicate very low aerosol SWCNT exposures at the workplace. Thus, the physiological relevance of these findings should ultimately be determined by conducting an inhalation toxicity study.
IEEE 802.11ah: A Technology to Face the IoT Challenge (2016)

Since the conception of the Internet of things (IoT), a large number of promising applications and technologies have been developed, which will change different aspects in our daily life. This paper explores the key characteristics of the forthcoming IEEE 802.11ah specification. This future IEEE 802.11 standard aims to amend the IEEE 802.11 legacy specification to support IoT requirements. We present a thorough evaluation of the foregoing amendment in comparison to the most notable IEEE 802.11 standards. In addition, we expose the capabilities of future IEEE 802.11ah in supporting different IoT applications. Also, we provide a brief overview of the technology contenders that are competing to cover the IoT communications framework. Numerical results are presented showing how the future IEEE 802.11ah specification offers the features required by IoT communications, thus putting forward IEEE 802.11ah as a technology to cater the needs of the Internet of Things paradigm.
Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells (1992)

Human immunodeficiency virus type 1 (HIV-1) can establish a persistent and latent infection in CD4+ T lymphocytes (W. C. Greene, N. Engl. J. Med. 324:308-317, 1991; S. M. Schnittman, M. C. Psallidopoulos, H. C. Lane, L. Thompson, M. Baseler, F. Massari, C. H. Fox, N. P. Salzman, and A. S. Fauci, Science 245:305-308, 1989). Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T. Folks, D. M. Powell, M. M. Lightfoote, S. Benn, M. A. Martin, and A. S. Fauci, Science 231:600-602, 1986; D. Zagury, J. Bernard, R. Leonard, R. Cheynier, M. Feldman, P. S. Sarin, and R. C. Gallo, Science 231:850-853, 1986). This activation is mediated by the host transcription factor NF-kappa B [G. Nabel and D. Baltimore, Nature (London) 326:711-717, 1987]. We report here that the HIV-1-encoded Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens. However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT. Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site. These results indicate that defective recruitment of NF-kappa B may underlie Nef's negative transcriptional effects on the HIV-1 and interleukin 2 promoters. Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.
CD4+CD25+ and CD4+CD25− T Cells Act Respectively as Inducer and Effector T Suppressor Cells in Superantigen-Induced Tolerance (2003)

Abstract The repeated injection of low doses of bacterial superantigens (SAg) is known to induce specific T cell unresponsiveness. We show in this study that the spleen of BALB/c mice receiving chronically, staphylococcal enterotoxin B (SEB) contains SEB-specific CD4+ TCRBV8+ T cells exerting an immune regulatory function on SEB-specific primary T cell responses. Suppression affects IL-2 and IFN-γ secretion as well as proliferation of T cells. However, the suppressor cells differ from the natural CD4+ T regulatory cells, described recently in human and mouse, because they do not express cell surface CD25. They are CD152 (CTLA-4)-negative and their regulatory activity is not associated with expression of the NF Foxp3. By contrast, after repeated SEB injection, CD4+CD25+ splenocytes were heterogenous and contained both effector as well as regulatory cells. In vivo, CD4+CD25− T regulatory cells prevented SEB-induced death independently of CD4+CD25+ T cells. Nevertheless, SEB-induced tolerance could not be achieved in thymectomized CD25+ cell-depleted mice because repeated injection of SEB did not avert lethal toxic shock in these animals. Collectively, these data demonstrate that, whereas CD4+CD25+ T regulatory cells are required for the induction of SAg-induced tolerance, CD4+CD25− T cells exert their regulatory activity at the maintenance stage of SAg-specific unresponsiveness.
Ex Vivo Expansion of Megakaryocyte Progenitor Cells: Cord Blood Versus Mobilized Peripheral Blood (2005)

Thrombocytopenia is a problematic and potentially fatal occurrence after transplantation of cord blood stem cells. This problem may be alleviated by infusion of megakaryocyte progenitor cells. Here, we compared the ability of hematopoietic progenitor cells obtained from cord blood and expanded in culture to that of mobilized peripheral blood cells. The CD34(+) cells were plated for 10 days in presence of thrombopoietin (TPO) alone and combined with stem cell factor (SCF), Flt3-ligand (FL), interleukin-3 (IL-3), IL-6, and IL-11. Cells were analyzed for the CD41 and CD42b expression and for their ploidy status. Ex vivo produced platelets were enumerated. We show that (1) TPO alone was able to induce differentiation of CD34(+) cells into CD41(+) cells, with limited total leucocyte expansion; (2) the addition of SCF to TPO decreased significantly CD41(+) cell percentage in CB, but not in MPB; and (3) in CB, the addition of FL, IL-6, and IL-11 to TPO increased the leukocyte expansion with differentiation and terminal maturation into MK lineage. In these conditions, high numbers of immature CD34(+)CD41(+) MK progenitor cells were produced. Our results thereby demonstrate a different sensitivity of CB and MPB cells to SCF, with limited CB MK differentiation. This different sensitivity to SCF (produced constitutively by BM stromal cells) could explain the longer delay of platelet recovery after CB transplant. Nevertheless, in CB, the combination of TPO with FL, IL-6, and IL-11 allows generation of a suitable number of immature MK progenitor cells expressing both CD34 and CD41 antigens, which are supposed to be responsible for the platelet recovery after transplantation.