gebhart/patrepeval huggingface dataset:
Tritium Generation and Large Excess Heat Evolution by Electrolysis in Light and Heavy Water-Potassium Carbonate Solutions with Nickel Electrodes (1994)

The generation of tritium was quantitatively measured in an electrolytic cell with a nickel cathode and a platinum anode in potassium carbonate-light and heavy water solutions. Simultaneously, the evolution of a large amount of excess heat (70 to 170% for the input power) was observed during electrolysis of these solutions. The tritium generation by electrolysis provides some of the most conclusive evidence for so-called cold fusion, along with the calcium generation described in a previous paper. On the basis of the current experiments and the knowledge of the kinetics of a hydrogen evolution reaction in an alkaline solution, the nuclear reactions taking place are worth mentioning.
Nitric oxide controls cardiac substrate utilization in the conscious dog (1999)

The acute inhibition of NO synthase by NLA causes a switch from fatty acids to lactate and glucose utilization by the heart which can be reversed by a NO donor, suggesting an important regulatory action of NO on cardiac metabolism.
Capecitabine in combination with irinotecan (XELIRI), administered as a 2-weekly schedule, as first-line chemotherapy for patients with metastatic colorectal cancer: a phase II study of the Spanish GOTI group (2009)

Capecitabine and irinotecan, given every 2 weeks, as first-line treatment of MCRC is an active regimen with a manageable toxicity profile, even in older patients.
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. (1992)

Nitric oxide (NO) is a messenger molecule of macrophages, endothelial cells in blood vessels, and neurons. A neuronal form of NO synthase (NOS) has been previously cloned. We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme. Like neuronal NOS, macrophage NOS has recognition sites for FAD, FMN, and NADPH and also has a consensus calmodulin binding site. Macrophage NOS mRNA is strikingly inducible; it is absent in quiescent macrophages or spleen but is prominent 2-6 hr after endotoxin treatment.
Compressed-domain techniques for image/video indexing and manipulation (2002)

As massive amount of visual materials are captured and stored in visual information systems, effective and efficient image indexing and manipulation techniques are required. Most visual materials in visual information systems are stored in some compressed forms. Therefore, it is desirable to explore image technologies for feature extraction and image manipulation in the compressed domain. In other words, image feature extraction and manipulation are performed on compressed images/video without decoding, or with minimal decoding only. Although the compressed-domain approach imposes many constraints, it provides great potential for reducing computational complexity, because of reduction of the amount of data after compression. This paper provides an overview of our research in this area. Specifically, it describes the results and the future directions of our work on compressed-domain texture feature extraction, image matching, image manipulation, and video indexing.
Circular RNAs: Biogenesis, Function and Role in Human Diseases (2017)

Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike linear RNAs, form covalently closed continuous loops and act as gene regulators in mammals. They were originally thought to represent errors in splicing and considered to be of low abundance, however, there is now an increased appreciation of their important function in gene regulation. circRNAs are differentially generated by backsplicing of exons or from lariat introns. Unlike linear RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together by covalent bonds leading to circularization. Interestingly, they have been found to be abundant, evolutionally conserved and relatively stable in the cytoplasm. These features confer numerous potential functions to circRNAs, such as acting as miRNA sponges, or binding to RNA-associated proteins to form RNA-protein complexes that regulate gene transcription. It has been proposed that circRNA regulate gene expression at the transcriptional or post-transcriptional level by interacting with miRNAs and that circRNAs may have a role in regulating miRNA function in cancer initiation and progression. circRNAs appear to be more often downregulated in tumor tissue compared to normal tissue and this may be due to (i) errors in the back-splice machinery in malignant tissues, (ii) degradation of circRNAs by deregulated miRNAs in tumor tissue, or (iii) increasing cell proliferation leading to a reduction of circRNAs. circRNAs have been identified in exosomes and more recently, chromosomal translocations in cancer have been shown to generate aberrant fusion-circRNAs associated with resistance to drug treatments. In addition, though originally thought to be non-coding, there is now increasing evidence to suggest that select circRNAs can be translated into functional proteins. Although much remains to be elucidated about circRNA biology and mechanisms of gene regulation, these ncRNAs are quickly emerging as potential disease biomarkers and therapeutic targets in cancer.
A survey of active network research (1997)

Active networks are a novel approach to network architecture in which the switches (or routers) of the network perform customized computations on the messages flowing through them. This approach is motivated by both lead user applications, which perform user-driven computation at nodes within the network today, and the emergence of mobile code technologies that make dynamic network service innovation attainable. The authors discuss two approaches to the realization of active networks and provide a snapshot of the current research issues and activities. They illustrate how the routers of an IP network could be augmented to perform such customized processing on the datagrams flowing through them. These active routers could also interoperate with legacy routers, which transparently forward datagrams in the traditional manner.
[Study of transcription of the DNA sequence of a mts271 clone in various tumor and normal mouse cells]. (1989)

Transcription of the mts271 gene was studied in 27 mouse cell tumor lines. Transcripts of the gene have been found in 6 out of 7 different metastatic lines. No transcription of the gene has been observed in non-metastatic tumor lines. In normal tissues, specific gene DNA was only found in hemopoietic cells--in bone marrow, spleen, thymus and lymphocytes. Transcription of the gene mts271 is not dependent on the level of DNA methylation.
Effects of erase source bias on Flash EPROM device reliability (1995)

This paper is concerned with the effects of the source bias during the erase operation on the reliability of Flash EPROM devices. It will be shown that positive charge in the tunnel oxide, mostly generated by the erase operation, is a major cause of the unintentional charge loss/gain mechanisms that disturb the data content of the memory cell. The effects of the erase source bias are evaluated in the context of the positive oxide charge generation and the resulting enhancement of the gate current that causes the data loss. An optimal source bias during erase, around 2 V for our samples, is shown to cause the least positive oxide charge. A model based on the band-to-band tunneling-induced hole generation in Si and subsequent hole injection during the erase operation is presented and discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Van de werkvloer (2008)

Sinds vorig schooljaar bereidt het ROC Midden Nederland leerlingen van de opleidingen Zorg & Welzijn concreter voor op de praktijk. Onder meer door in de lessen vrijwilligers in te zetten die een aandoening of ziekte ‘acteren’. Maar ook via samenwerking met vrijwilligersorganisatie De Zonnebloem. ‘Zo kunnen we een reëler beeld van de werkelijkheid neerzetten.’
Transcriptome profiling of prostate tumor and matched normal samples by RNA-Seq. (2014)

These findings suggest the important usage of RNA-Seq in cancer studies for biomarker development and functional investigation.
Attenuation of sound in concentrated suspensions: theory and experiments (2001)

Ensemble-averaged equations are derived for small-amplitude acoustic wave propagation through non-dilute suspensions. The equations are closed by introducing effective properties of the suspension such as the compressibility, density, viscoelasticity, heat capacity, and conductivity. These effective properties are estimated as a function of frequency, particle volume fraction, and physical properties of the individual phases using a self-consistent, effective-medium approximation. The theory is shown to be in excellent agreement with various rigorous analytical results accounting for multiparticle interactions. The theory is also shown to agree well with the experimental data on concentrated suspensions of small polystyrene particles in water obtained by Allegra &amp; Hawley and for glass particles in water obtained in the present study.
N‐Myristoyltransferase: a Prospective Drug Target for Protozoan Parasites (2008)

Parasite specific: The inhibition of myristoyl-CoA:protein N-myristoyltransferase (NMT) can lead to parasite death in culture. Herein we review recent work that supports the suitability of NMT as a parasite-specific drug target. The example shown illustrates the peptidomimetic compound 2, which is more stable, yet retains the Ser and Lys functional groups of compound 1 that are necessary for NMT inhibition.
Flow synthesis of arylboronic esters bearing electrophilic functional groups and space integration with Suzuki–Miyaura coupling without intentionally added base (2012)

We found that an integrated flow microreactor system enables the preparation of boronic esters bearing electrophilic functional groups using organolithium chemistry and that it allows for their use in Suzuki-Miyaura cross-coupling without intentionally added base. Based on this method, cross-coupling of two aryl halides bearing electrophilic functional groups was accomplished to obtain the corresponding biaryl compounds in one flow.
Treatment of Antibiotic-Associated Pseudomembranous Colitis (1984)

The experience of this laboratory with the treatment of Clostridium-induced colitis in experimental animals and in patients was reviewed. Optimal results in hamsters were achieved with the antibiotics vancomycin, metronidazole, and tetracycline. Cholestyramine was less effective. The outcome for animals given corticosteroids and Clostridium sordellii antitoxin systemically was not different from that for untreated control animals. The second facet of the study was a retrospective review of therapy in 272 patients with C. difficile-induced diarrhea or colitis. No specific therapy was given to 56 patients who had mild symptoms or were improving at the time the toxin was detected. The therapy most frequently used was oral vancomycin, which was given to 189 patients, including 100 with confirmed pseudomembranous colitis. The response rate was 97%, but 46 patients (24%) relapsed when treatment was discontinued. Response to cholestyramine was favorable in 12 of 19 patients. The results with metronidazole and bacitracin were uniformly good, although the experience was limited.
Detection of Human Leukocyte Interferon-αA and -α 2 Genes in Genomic DNAs by the Use of Deoxyoctadecyloligonucleotide Probes (1988)

Two deoxyoctadecyloligonucleotides complementary to the sequence spanning a single base substitution between human leukocyte interferon (HuIFN) alpha A and alpha 2 genes were efficiently used as probes to distinguish between HuIFN-alpha A and -alpha 2 genes. At 37 degrees C or 42 degrees C under aqueous conditions (0.9 M NaCl), hybridization between both probes and the alpha A and alpha 2 genes without any mismatch was strong, whereas the hybridization with one base mismatch (alpha A probe-alpha 2 gene and alpha 2 probe-alpha A gene) was very weak or negligible. Because the single base substitution of G in the alpha 2 gene for A in the alpha A gene provides an extra HinfI site in the alpha 2 gene at the center of the sequence hybridizing to the alpha 2 probe, digestion with HinfI restriction endonuclease caused complete loss of the hybridization between the alpha 2 probe and the alpha 2 gene. PvuII digestion provides 298-bp fragments hybridizing to the probes only from the alpha A and alpha 2 genes among the known HuIFN-alpha genes. Thus, with the use of these oligonucleotide probes in combination with PvuII and PvuII-HinfI restriction endonuclease digestion, the existence of the sequences corresponding to both IFN-alpha A and IFN-alpha 2 genes in human genomic DNAs was demonstrated. The results also surprisingly indicate that these genes, formerly considered alleles because of their essential identity (1 base pair difference in the coding sequence), are not likely to be alleles, but represent closely related distinct genes.
Is One of the E’s in IEEE for Environmental? (1998)

Every year the Industrial Electrolysis and Electrochemical Engineering (IEEE) Division of ECS sponsors a Report of the Electrolytic Industries for the past year. Even as far back as 1980, either in a footnote or later as the first paragraph in the report, it states that, “environmental aspects in the electrolytic and related industries” also are summarized.
ChemInform Abstract: Organometallic Reagents in Synthesis. A New Protocol for Construction of the Indole Nucleus. (1986)

Abstract Organolithium reagents derived from 2‐alkyl‐N‐trimethylsilylamines such as (I) undergo condensation with esters of carboxylic acids to yield substituted indoles (III)..
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. (2000)

Estrogen acts to promote DNA synthesis in the MCF-7 human breast cancer cell line via its interaction with high levels of estrogen receptor. The primary mode of estrogen action has been considered to be through transcriptional activation of genes containing estrogen response elements, including the immediate early genes c-myc and fos. Recent reports have indicated that estrogen, acting through the estrogen receptor, is capable of inducing the mitogen-activated protein kinase (MAPK) cytoplasmic signaling cascade. In this study, specific small molecule inhibitors of MAPK and phosphatidylinositol 3-kinase activity were used to determine the influence of these cascades on estrogen-mediated mitogenesis. Phosphatidylinositol 3-kinase inhibitors, LY294002 and wortmannin, as well as inhibitors of MAPK kinase-1, PD098059 and U0126, decreased the fraction of cells entering DNA synthesis after treatment with 17beta-estradiol. These compounds did not inhibit expression of myc or fos. However, the drugs did prevent the accumulation of cyclin D1 and hyperphosphorylated retinoblastoma protein, indicating that the block occurred at, or prior to, this point in the cell cycle. Although these compounds were effective in preventing estrogen-mediated mitogenesis, the downstream kinases extracellular signal-regulated kinase 1, extracellular signal-regulated kinase 2, and protein kinase B were not activated over basal levels by estrogen treatment. These studies suggest that estrogen initiates mitogenesis by inducing the transcription of immediate early genes, but cytoplasmic signaling pathways play an important role in the control of subsequent events in the cell cycle.
Recombinant Hemoglobin(α29Leucine → Phenylalanine, α96Valine → Tryptophan, β108Asparagine → Lysine) Exhibits Low Oxygen Affinity and High Cooperativity Combined with Resistance to Autoxidation (1999)

Using our hemoglobin expression system in Escherichia coli, we have constructed three recombinant hemoglobins (rHbs) with amino acid substitutions located in the alpha(1)beta(1) and alpha(1)beta(2) subunit interfaces and in the distal heme pocket of the alpha-chain: rHb(alphaV96W, betaN108K), rHb(alphaL29F, alphaV96W, betaN108K), and rHb(alphaL29F). rHb(alphaV96W, betaN108K) exhibits low oxygen affinity and high cooperativity and also ease of autoxidation of the heme iron atoms from the Fe2+ state to the Fe3+ state. It has been reported by Olson and co-workers [Carver et al., (1992) J. Biol. Chem. 267, 14443-14450; Brantley et al. (1993) J. Biol. Chem. 268, 6995-7010] that a mutation at position 29 (B10, helix notation), e.g. , Leu --> Phe, can inhibit the autoxidation of the heme iron of myoglobin. We have introduced such a mutation into our rHb having low oxygen affinity and high cooperativity. This triply mutated rHb(alphaL29F, alphaV96W, betaN108K) is stabilized against autoxidation and azide-induced oxidation compared to the double mutant, rHb(alphaV96W, betaN108K), but still exhibits low oxygen affinity and good cooperativity. According to electron paramagnetic resonance results, the oxidized form of the triple mutant shows a high ratio of an anionic form of bishistidine hemichrome. Previous reports have suggested that this form does not have water present at the distal heme pocket. (1)H nuclear magnetic resonance spectra of the triple mutant in the ferric state also exhibit spectral features characteristic of hemichrome-type signals. We have carried out a series of biochemical measurements to characterize these three interesting rHbs and to compare them to human normal adult hemoglobin. These results provide new insights into the structure-function relationship of hemoglobin with amino acid substitutions in the alpha(1)beta(1) and alpha(1)beta(2) interfaces and in the heme pockets.
New Methods in Peptide Synthesis. I. Tritylsulfenyl and o-Nitrophenylsulfenyl Groups as N-Protecting Groups (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Methods in Peptide Synthesis. I. Tritylsulfenyl and o-Nitrophenylsulfenyl Groups as N-Protecting GroupsLeonidas. Zervas, Dimitrios. Borovas, and Euthymios. GazisCite this: J. Am. Chem. Soc. 1963, 85, 22, 3660–3666Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/ja00905a029https://doi.org/10.1021/ja00905a029research-articleACS PublicationsRequest reuse permissionsArticle Views831Altmetric-Citations228LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Lithographic Performance and Contamination Resistance of a New Family of Chemically Amplified DUV Photoresists. (1994)

A new contamination resistant 248 nm I)IJV resist (ESCAP-E) has been developed to alleviate the difficulties encountered with the environmental contamination sensitivity of chemically amplified DIJV photoresists. The formulation and processing of ESCAP-I; have been designed to permit thermal annealing of resist films to reduce the free volume and dif lusivity of airborne contaminants into the resist film. The resist formulation is robust enough to permit post exposure bake delays of up to four hours without change or reduction of resist lithographic performance.
B7-H4 Is a Novel Membrane-Bound Protein and a Candidate Serum and Tissue Biomarker for Ovarian Cancer (2006)

Using cDNA database mining strategies and real-time quantitative reverse transcription-PCR, we identified B7-H4 as a novel gene that is overexpressed in ovarian and breast cancer tissues when compared with normal tissues. The gene encodes a protein of 282 amino acids with a signal sequence, an immunoglobulin domain, and a COOH-terminal hydrophobic transmembrane domain. Immunohistochemistry experiments show plasma membrane staining in serous ovarian and breast cancer, confirming the tissue specificity and cell surface localization. We have developed a sensitive dual monoclonal antibody sandwich ELISA to analyze the level of B7-H4 protein in >2,500 serum samples, ascites fluids, and tissue lysates. High levels of B7-H4 protein were detected in ovarian cancer tissue lysates when compared with normal tissues. B7-H4 was present at low levels in all sera but showed an elevated level in serum samples from ovarian cancer patients when compared with healthy controls or women with benign gynecologic diseases. The median B7-H4 concentration in endometrioid and serous histotypes was higher than in mucinous histotypes, consistent with results of immunohistochemical staining. The multivariate logistic regression analysis of B7-H4 and CA125 measured in the same sample set resulted in an area under the curve (AUC) of 0.86 for all stages and 0.86 for stage I/II patients, which was significantly higher than the AUC for either marker alone. In early-stage patients, the sensitivity at 97% specificity increased from 52% for CA125 alone to 65% when used in combination with B7-H4. We conclude that B7-H4 is a promising new biomarker for ovarian carcinoma.
Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. (1993)

It is concluded that chronic DHEA administration in a hypercholesterolemic rabbit model of heterotopic cardiac transplantation significantly retards the progression of accelerated atherosclerosis in both the transplanted heart and in the native heart.
Bacterial extract (OM-89) specific and non specific immunomodulation in rheumatoid arthritis patients (2006)

The Escherichia Coli bacterial extract (OM-89) is used in the treatment of rheumatoid arthritis (RA). We evaluated the immunological changes induced by oral administration of OM-89 in 12 RA patients (polyclonal T cell reactivity to PHA, T cell precursor frequencies specific for OM-89 and Tetanus toxoid (TT), a control antigen and the release of Th1 (IFN-gamma, TNF-alpha), Th2 (IL-4) and T regulatory 1 cell (Tr1) (IL-10) cytokines in the supernatants of PBMC cultures. Stimulation index in response to PHA decreased at month 3 as well as T cell precursor frequencies specific for TT with similar trends for OM-89-specific T cell precursor frequencies. OM-89 induced a strong production of IL-10, a significant decrease in IL-4 production while TNF-alpha and IFN-gamma production tended to decrease during the study. Our results suggest that OM-89 has immunomodulatory properties by inducing changes in PBMC cytokines release suggestive of an induced Tr1 response to OM-89.