gebhart/patrepeval huggingface dataset:
Acoustic vector-sensor beamforming and Capon direction estimation (1998)

We examine the improvement attained by using acoustic vector-sensors for direction-of-arrival (DOA) estimation, instead of traditional pressure sensors, via optimal performance bounds and particular estimators. By examining the Cramer-Rao bound in the case of a single source, we show that a vector-sensor array's smaller estimation error is a result of two distinct phenomena: (1) an effective increase in signal-to-noise ratio due to a greater number of measurements of phase delays between sensors and (2) direct measurement of the DOA information contained in the structure of the velocity field due to the vector sensors' directional sensitivity. Separate analysis of these two phenomena allows us to determine the array size, array shape, and SNR conditions under which the use of a vector-sensor array is most advantageous and to quantify that advantage. By extending the beamforming and Capon (1969) direction estimators to vector-sensors, we find that the vector-sensors' directional sensitivity removes all bearing ambiguities. In particular, even simple structures such as linear arrays can determine both azimuth and elevation, and spatially undersampled regularly spaced arrays may be employed to increase the aperture and, hence, the performance. Large sample approximations to the mean-square error matrices of the estimators are derived and their validity is assessed by Monte Carlo simulation.
Investissement et réactivité permanente. Les bibliothèques de l’université Versailles-St-Quentin-en-Yvelines (2018)

C’est des la fin de 2011 que, dans les BU de l’universite de Versailles-St-Quentin-en-Yvelines (UVSQ), sont creees cinq pages Facebook. L’ensemble des personnels sont sensibilises aux reseaux sociaux puis inities au maniement de Facebook, avec une volonte de participation libre. Les personnels volontaires, toutes categories confondues, creent leurs comptes pro pour participer a l’animation des pages, en fonction de leur BU d’origine et de leurs sujets privilegies. L’objectif etait d’associer ...
Evidence for functional role of εPKC isozyme in the regulation of cardiac Ca2+channels (2000)

Investigation of the role of individual protein kinase C (PKC) isozymes in the regulation of Na(+) channels has been largely limited by the lack of isozyme-selective modulators. Here we used a novel peptide-specific activator (epsilonV1-7) of epsilonPKC and other peptide isozyme-specific inhibitors in addition to the general PKC activator phorbol 12-myristate 13-acetate (PMA) to dissect the role of individual PKCs in the regulation of the human cardiac Na(+) channel hH1, heterologously expressed in Xenopus oocytes. Peptides were injected individually or in combination into the oocyte. Whole cell Na(+) current (I(Na)) was recorded using two-electrode voltage clamp. epsilonV1-7 (100 nM) and PMA (100 nM) inhibited I(Na) by 31 +/- 5% and 44 +/- 8% (at -20 mV), respectively. These effects were not seen with the scrambled peptide for epsilonV1-7 (100 nM) or the PMA analog 4alpha-phorbol 12,13-didecanoate (100 nM). However, epsilonV1-7- and PMA-induced I(Na) inhibition was abolished by epsilonV1-2, a peptide-specific antagonist of epsilonPKC. Furthermore, PMA-induced I(Na) inhibition was not altered by 100 nM peptide-specific inhibitors for alpha-, beta-, delta-, or etaPKC. PMA and epsilonV1-7 induced translocation of epsilonPKC from soluble to particulate fraction in Xenopus oocytes. This translocation was antagonized by epsilonV1-2. In native rat ventricular myocytes, PMA and epsilonV1-7 also inhibited I(Na); this inhibition was antagonized by epsilonV1-2. In conclusion, the results provide evidence for selective regulation of cardiac Na(+) channels by epsilonPKC isozyme.
Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4-demethoxy-7,9-diepidaunorubicin, and their beta anomers. (1976)

Four new derivatives of daunorubicin, characterized by the absence of the methoxyl group at the C-4 position, have been obtained by chemical synthesis. 4-Demethoxydaunorubicin (NSC-256439) was effective against L1210 and Gross leukemias and ascites and solid Sarcoma 180 at doses four to eight times lower than those effective for daunorubicin. The beta anomer of 4-demethoxydaunorubicin was active at doses 13and eight times higher than those of its corresponding alpha anomer against L1210 and Gross leukemias respectively. 4-Demethoxy-7,9-diepidaunorubicin and its beta anomer were devoid of any biologic activity at the doses tested.
Bitcoin mining acceleration and performance quantification (2014)

Since its introduction in 2009, Bitcoin, an open source, peer to peer, digital crypto currency has been growing in popularity and wide spread use. Growing attention, recognition by major financial institutions and high valued currency units (BTC) ascertains Bitcoin to a sturdy and ever increasing choice of currency. A public transaction log called the “Blockchain” keeps records of all committed transactions and Bitcoin ownership details, that is, addresses derived by cryptographic keys. Bitcoin mining, a process which results in the generation of new Bitcoins, is performed by miner operators for reception of incentives in the form of Bitcoins. This mining process is essentially operations of SHA-256 hashing of values in search of a hash digest smaller than a specific value. Once this winning hash has been discovered, a new block to Blockchain is added and BTC incentives are furnished by the Bitcoin network to the miner. This paper discusses methods of performing Bitcoin mining on non-custom hardware which results in contextually faster mining by combined usage of computing elements within machines in mining networks, both illegal and legal.
Functionalization of Silica Nanoparticles via the Combination of Surface-Initiated RAFT Polymerization and Click Reactions (2008)

A functional monomer with a pendant azide moiety, 6-azidohexyl methacrylate (AHMA), was polymerized on the surface of silica nanoparticles via surface-initiated reversible addition−fragmentation chain transfer (RAFT) polymerization with considerable control over the molecular weight and molecular weight distribution. The kinetics of AHMA polymerization mediated by 4-cyanopentanoic acid dithiobenzoate (CPDB) anchored nanoparticles was investigated and compared with that of AHMA polymerization mediated by free CPDB under similar conditions. The subsequent postfunctionalizations of PAHMA-grafted nanoparticles were demonstrated by reacting with various functional alkynes via click reactions. Kinetic studies showed that the reaction of surface-grafted PAHMA with phenylacetylene surface-grafted PAHMA was much faster than that of free PAHMA with phenylacetylene, whereas in the case of high molecular weight alkynes surface-grafted PAHMA showed lower reaction rates as compared to free PAHMA.
The impact of sanitation interventions on latrine coverage and latrine use: A systematic review and meta-analysis (2016)

Our results indicate that most sanitation interventions only had a modest impact on increasing latrine coverage and use. A further understanding of how different sanitation characteristics and sanitation interventions impact coverage and use is essential in order to more effectively attain sanitation access for all, eliminate open defecation, and ultimately improve health.
Expression of the Surface Glycoproteins of Human Parainfluenza Virus Type 3 by Bovine Parainfluenza Virus Type 3, a Novel Attenuated Virus Vaccine Vector (2000)

Bovine parainfluenza virus type 3 (bPIV3) is being evaluated as an intranasal vaccine for protection against human PIV3 (hPIV3). In young infants, the bPIV3 vaccine appears to be infectious, attenuated, immunogenic, and genetically stable, which are desirable characteristics for an RNA virus vector. To test the potential of the bPIV3 vaccine strain as a vector, an infectious DNA clone of bPIV3 was assembled and recombinant bPIV3 (r-bPIV3) was rescued. r-bPIV3 displayed a temperature-sensitive phenotype for growth in tissue culture at 39 degrees C and was attenuated in the lungs of Syrian golden hamsters. In order to test whether r-bPIV3 could serve as a vector, the fusion and hemagglutinin-neuraminidase genes of bPIV3 were replaced with those of hPIV3. The resulting bovine/human PIV3 was temperature sensitive for growth in Vero cells at 37 degrees C. The replication of bovine/human PIV3 was also restricted in the lungs of hamsters, albeit not as severely as was observed for r-bPIV3. Despite the attenuation phenotypes observed for r-bPIV3 and bovine/human PIV3, both of these viruses protected hamsters completely upon challenge with hPIV3. In summary, bPIV3 was shown to function as a virus vector that may be especially suitable for vaccination of infants and children against PIV3 and other viruses.
Reconstruction of the canine Achilles and patellar tendons using Dacron mesh silicone prosthesis. I. Clinical and biocompatibility evaluation (1976)

Surgical replacement of the Achilles and patellar tendons using Dacron mesh silicone prostheses was performed in 15 mature beagle dogs. This part of the study includes clinical evaluation, gross inspection at autopsy of regrown tendons, and histological determination of biocompatibility of prosthetic implants. Functional continuity and integrity of prosthetic patellar tendons have been established by evaluating the biologic-prosthetic interface and the mechanical properties of regrown tendon tissue around and through the Dacron silicone replacements. Results of prosthetic Achilles tendons were less satisfactory because of difficulties in suturing to a muscle and its fascia. Although the prosthetic tendon did not regrow through the tube, it provided a structure for regrowth around it. The regrown tendons became nearly ten times the normal cross-sectional area after three to four months and decreased to two to three times after 13 months. Histological studies indicate that in the absence of infection, the Dacron mesh silicone tendon was well tolerated for periods up to 13 months. Overall results are encouraging and warrant further investigation although the regenerative capacity of human patellar and Achilles tendons is unknown.
Telomere Shortening in Human Coronary Artery Diseases (2004)

These findings suggest that focal replicative senescence and telomere shortening of endothelial cells may play a critical role in coronary atherogenesis and CAD.
Can Guideline-defined Asthma Control Be Achieved? (2004)

For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively studied. A 1-year, randomized, stratified, double-blind, parallel-group study of 3,421 patients with uncontrolled asthma compared fluticasone propionate and salmeterol/fluticasone in achieving two rigorous, composite, guideline-based measures of control: totally and well-controlled asthma. Treatment was stepped-up until total control was achieved (or maximum 500 microg corticosteroid twice a day). Significantly more patients in each stratum (previously corticosteroid-free, low- and moderate-dose corticosteroid users) achieved control with salmeterol/fluticasone than fluticasone. Total control was achieved across all strata: 520 (31%) versus 326 (19%) patients after dose escalation (p < 0.001) and 690 (41%) versus 468 (28%) at 1 year for salmeterol/fluticasone and fluticasone, respectively. Asthma became well controlled in 1,071 (63%) versus 846 (50%) after dose escalation (p < 0.001) and 1,204 (71%) versus 988 (59%) at 1 year. Control was achieved more rapidly and at a lower corticosteroid dose with salmeterol/fluticasone versus fluticasone. Across all strata, 68% and 76% of the patients receiving salmeterol/fluticasone and fluticasone, respectively, were on the highest dose at the end of treatment. Exacerbation rates (0.07-0.27 per patient per year) and improvement in health status were significantly better with salmeterol/fluticasone. This study confirms that the goal of guideline-derived asthma control was achieved in a majority of the patients.
Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects (2010)

Veltuzumab is a humanized, anti-CD20 monoclonal IgG(1) antibody (MAb), constructed recombinantly on the framework regions of epratuzumab, with complementarity-determining regions (CDRs) identical to rituximab, except for a single amino acid in CDR3 of the variable heavy chain. Veltuzumab showed anti-proliferative, apoptotic, and antibody-dependent cellular cytotoxicity effects in vitro similar to rituximab, but with significantly slower off-rates and increased complement-dependent cytotoxicity in several human lymphoma cell lines. In addition, very low doses of veltuzumab, given either intravenously or subcutaneously, depleted B cells in normal cynomolgus monkeys, and controlled tumor growth in mice bearing human lymphomas. Clinically, veltuzumab has been studied in > 150 patients with lymphomas and autoimmune diseases. In non-Hodgkin lymphoma (NHL), infusions of 80-750 mg/m(2) were well tolerated when given once-weekly for four doses, with the only toxicity being transient mild-moderate infusion reactions. Objective tumor responses, including durable complete responses, occurred at all dose levels. Subcutaneous injections of low doses (80-320 mg) have also proved to be safe and pharmacologically active, producing objective responses, including durable complete responses, at rates comparable to those reported with rituximab, in patients with NHL and immune thrombocytopenia.
Where were we (1993)

Where Were We" is a prototype system that exploits the capabilities of digital video to allow groups to include recordings of very recent events into real-time activities. The goals of the research are to see how playback-while-recording and random access capabilities might substantially alter the activity of group work, to discover what difficulties arise in using emerging digital multimedia hardware and software facilities for this kind of application, and to further explore how to base novel systems design on necessarily partial and fragmented observations of actual work activity.
Estradiol induces functional inactivation of p53 by intracellular redistribution. (2000)

Estrogen treatment of MCF-7 cells grown in serum-free medium induced a modification of the intracellular distribution of p53 protein. Western blot analysis and immunofluorescence staining showed that p53 was localized in the nucleus of untreated cell and that after 48 h of hormone treatment, it was mostly localized in the cytoplasm. This effect was blocked by the antiestrogen ICI182,780. Intracellular redistribution of p53 was correlated to a reduced expression of the WAF1/CIP1 gene product and to the presence of degradation fragments of p53 in the cytosol. Estradiol treatment prevented the growth inhibition induced by oligonucleotide transfection, simulating DNA damage. This observation indicated that the wild-type p53 gene product present in the MCF-7 cell could be inactivated by estradiol through nuclear exclusion to permit the cyclin-dependent phosphorylation events leading to the G1-S transition. In addition, the estradiol-induced inactivation of p53 could be involved in the tumorigenesis of estrogen-dependent neoplasm.
Wind Speed and Rotor Position Sensorless Control for Direct-Drive PMG Wind Turbines (2010)

Wind turbine generators (WTGs) are usually equipped with mechanical sensors to measure wind speed and rotor position for system control, monitoring, and protection. The use of mechanical sensors increases the cost and hardware complexity and reduces the reliability of the WTG system. This paper proposes a wind speed and rotor position sensorless control for wind turbines directly driving permanent magnetic generators (PMGs). A sliding mode observer is designed to estimate the rotor position of the PMG, which is then used to calculate the shaft rotating speed. Based on the measured output electrical power and estimated rotor speed of the PMG, the mechanical power of the turbine is estimated by taking account into the power losses of the WTG system. A back propagation artificial neural network (BPANN) is then designed to estimate the wind speed in real time by using the estimated turbine shaft speed and mechanical power. The estimated wind speed is used to determine the optimal shaft speed or power reference for the PMG control system. Finally, a sensorless control is developed for the PMG wind turbines to continuously generate the maximum electrical power without using any wind speed or rotor position sensors. The validity of the proposed estimation and control algorithms are shown by simulation studies on a 3-kW PMG wind turbine and are further demonstrated by experimental results on a 300-W practical PMG wind turbine.
Structure of the gene 2.5 protein, a single-stranded DNA binding protein encoded by bacteriophage T7 (2001)

The gene 2.5 protein (gp2.5) of bacteriophage T7 is a single-stranded DNA (ssDNA) binding protein that has essential roles in DNA replication and recombination. In addition to binding DNA, gp2.5 physically interacts with T7 DNA polymerase and T7 primase-helicase during replication to coordinate events at the replication fork. We have determined a 1.9-A crystal structure of gp2.5 and show that it has a conserved OB-fold (oligosaccharide/oligonucleotide binding fold) that is well adapted for interactions with ssDNA. Superposition of the OB-folds of gp2.5 and other ssDNA binding proteins reveals a conserved patch of aromatic residues that stack against the bases of ssDNA in the other crystal structures, suggesting that gp2.5 binds to ssDNA in a similar manner. An acidic C-terminal extension of the gp2.5 protein, which is required for dimer formation and for interactions with the T7 DNA polymerase and the primase-helicase, appears to be flexible and may act as a switch that modulates the DNA binding affinity of gp2.5.
Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H‐NS‐dependent repression (2001)

Secretion of effector proteins in enteropathogenic Escherichia coli (EPEC) is mediated by a specialized type III secretion system whose components are encoded in the LEE1, LEE2 and LEE3 operons. Using cat transcriptional fusions and primer extension analysis, we determined that the LEE2 and LEE3 operons are expressed from two overlapping divergent promoters, whose expression is negatively regulated by flanking common upstream and downstream silencing regulatory sequences (SRS1 and SRS2). In the absence of either SRS1 or SRS2, expression of the LEE2 and LEE3 operons became independent of Ler, a positive regulatory protein encoded by the first gene of the LEE1 operon. Similarly, in the absence of the histone-like protein H-NS, expression from both promoters became Ler independent even if both SRSs were present. In addition, the efficient expression of both the LEE2 and the LEE3 promoters required PerC (BfpW), a protein coded by the third gene of the per (bfpTVW) locus, but only in the presence of the EAF plasmid. Our deletion analysis also showed that the negative regulation observed in the presence of ammonium or at temperatures above 37 degrees C (e.g. 40 degrees C) required the SRSs or elements located therein. In contrast, the negative regulation observed in LB or at temperatures below 37 degrees C (e.g. 25 degrees C) was still observed even in the absence of both SRSs and seems to act only on the promoters. Together, these results suggest that Ler acts as an antirepressor protein that overcomes the H-NS-mediated silencing on the LEE2/LEE3 divergent promoter region, which is probably caused by the formation of a repressing H-NS-nucleoprotein complex.
Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy (2004)

Long-term treatment of GEO xenografts with selective EGFR inhibitors results in the development of EGFR inhibitor-resistant cancer cells. Growth of EGFR inhibitor-resistant tumors can be inhibited by ZD6474. These data indicate that inhibition of VEGF signaling has potential as an anticancer strategy, even in tumors that are resistant to EGF inhibitors.
ChemInform Abstract: STUDIES IN THE HETEROCYCLIC RADICAL SERIES‐ PART XIV. 3,4‐DIMETHYLISOXAZOL‐5‐YL RADICALS. REACTIVITY IN THE AROMATIC AND HETEROAROMATIC SERIES‐ NEW ROUTE TO THE PREPARATION OF 3,4‐DIMETHYLISOXAZOLES C(5)‐SUBSTITUTED BY ARYL AND HETEROARYL GROUPS (1976)

Abstract Die aprotische Zersetzung des Aminoisoxazols (I) mit überschüssigem Isoamyl(iAm)‐ nitrit in aromatischen (ArH) und heteroaromatischen (HarH) Lösungsmitteln führt zu Isoxazolen, wie z.B. (II).
Minimally invasive transapical beating heart aortic valve implantation — proof of concept (2006)

Minimally invasive beating heart TAP-AVI is feasible. Initial results are encouraging in view of the high-risk profile of the patients. Long-term studies as well as randomized protocols are required.
Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles. (1994)

We have examined the range of mucosal and systemic immune responses induced by oral or parenteral immunization with ovalbumin (OVA) entrapped in poly(D,L-lactide-co-glycolide) (PLG) microparticles. A single subcutaneous immunization with OVA-PLG primed significant OVA-specific IgG and delayed-type hypersensitivity (DTH) responses. The DTH responses were of similar magnitude to those obtained using immunostimulating complexes (ISCOMS) as a potent control adjuvant, although ISCOMS stimulated higher serum IgG responses. Both vectors also primed OVA-specific in vitro proliferative responses in draining lymph node cells following a single immunization and strong OVA-specific CTL responses were found after intraperitoneal (i.p.) immunization. ISCOMS were more efficient in inducing cytotoxic T lymphocytes (CTL), requiring much less antigen and only ISCOMS could stimulate primary OVA-specific CTL responses in the draining lymph nodes. Multiple oral immunizations with OVA in PLG microparticles or in ISCOMS resulted in OVA-specific CTL responses and again ISCOMS seemed more potent as fewer feeds were necessary. Lastly, multiple feeds of OVA in PLG microparticles generated significant OVA-specific intestinal IgA responses. This is the first demonstration that PLG microparticles can stimulate CTL responses in vivo and our results highlight their ability to prime a variety of systemic and mucosal immune responses which may be useful in future oral vaccine development.
A New Culture System to Study the Metabolism of the Intervertebral Disc In Vitro (1998)

This new alginate tissue culture system should prove useful for studying the metabolism of whole intervertebral discs.
Incidence, Causes, and Outcomes of Dilated Cardiomyopathy in Children (2006)

In children, DCM is a diverse disorder with outcomes that depend largely on cause, age, and heart failure status at presentation. Race, sex, and age affect the incidence of disease. Most children do not have a known cause of DCM, which limits the potential for disease-specific therapies.