gebhart/patrepeval huggingface dataset:
IFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity (2008)

Interferon (IFN)lambda, also known as IL-28A, IL-28B or IL-29, is a new type III IFN, which like type I IFN(alpha/beta), activates common elements of the JAK/STAT signaling pathway and exhibits antiproliferative activity. Currently, IFNalpha is used in the treatment of certain forms of cancer, but its antitumor effects are limited and associated with high toxicity. In this study, we determined whether IFNlambda induced the same level of cell growth inhibition relative to IFNalpha. To this effect HaCaT cells, which are typically growth inhibited by IFNalpha, underwent apoptosis in response to IFNlambda. Next, in contrast to IFNalpha stimulation, IFNlambda prolonged the duration of activated STAT1 and STAT2. Furthermore, the kinetics of IFN-stimulated genes was different as IFNlambda induced a delayed but stronger induction of IFN-responsive genes. Components of the JAK/STAT pathway remained essential for the antiproliferative effects of IFNalpha and IFNlambda. IFNlambda-induced persistence of STAT activation required de novo protein synthesis and was in part due to a delay in STAT2 inactivation. Thus our data demonstrate that the duration of IFNlambda signaling is different from that of IFNalpha, and that IFNlambda could be a suitable cytokine to evaluate for cancer therapy.
Synthetic pharmacotherapy for lupus nephritis (2017)

Lupus nephritis is a frequent complication and a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Area covered: The main characteristics and mechanisms of action of the synthetic drugs more frequently used in lupus nephritis are described. Possible strategies aimed to reduce the potential adverse events without affecting efficacy are reported. Expert opinion: Many synthetic immunosuppressive drugs used in lupus nephritis have a low therapeutic index. Good knowledge of their pharmacologic characteristics, mechanisms of action, and drug-to-drug interactions, coupled with a strategy aimed to increase immunosuppression in the active phases of SLE while reducing the dosage in quiescent periods can reduce the iatrogenic morbidity while maintaining efficacy. Biologic agent may allow to reduce the use or the dosage of synthetic immunosuppressive drugs.
Polynomial and standard higher order neural network (2002)

The generalized back propagation algorithm is extended to multi-layer higher-order neural networks (HONNs). The performance of HONNs is presented. Two basic structures, the standard form and the polynomial form, are discussed. The performance of these two structures is compared using the classical TC test case, the geometric rotation problem. Simulation results show that both types of constructing strategies can recognize noisy data under rotation up to 70% and noisy irrational data up to 94%. The effect of the number of hidden neurons is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A survey of sequence alignment algorithms for next-generation sequencing (2010)

Rapidly evolving sequencing technologies produce data on an unparalleled scale. A central challenge to the analysis of this data is sequence alignment, whereby sequence reads must be compared to a reference. A wide variety of alignment algorithms and software have been subsequently developed over the past two years. In this article, we will systematically review the current development of these algorithms and introduce their practical applications on different types of experimental data. We come to the conclusion that short-read alignment is no longer the bottleneck of data analyses. We also consider future development of alignment algorithms with respect to emerging long sequence reads and the prospect of cloud computing.
Olefin Metathesis for Effective Polymer Healing via Dynamic Exchange of Strong Carbon–Carbon Double Bonds (2012)

In this article, we demonstrate transition-metal-catalyzed olefin metathesis as a simple, effective method for healing polymers via dynamic exchange of strong carbon-carbon double bonds. Upon introducing a very low level of the Grubbs' second-generation Ru metathesis catalyst into cross-linked polybutadiene (PBD) network, the material self-heals effectively at various conditions under moderate pressures. In sharp contrast, catalyst-free control samples with identical network topology and cross-linking density show minimal healing. The healing efficiency of the materials was carefully investigated under different concentrations of the Ru catalyst, compression pressures, and temperatures. It is demonstrated for the first time that a bulk polymer could effectively heal via dynamic covalent bond formation at sub-ambient temperature. The Ru-loaded PBD samples not only heal well with themselves but also with control samples without any catalyst. Furthermore, a completely Ru-free PBD network can heal effectively upon simply applying a very small amount of Ru catalyst only at the fracture surface. The simplicity and effectiveness of this self-healing approach make it potentially applicable to a wide range of olefin-containing polymers.
p53 and Neoplastic Progression in Barrett's Esophagus (2001)

Fred Hutchinson Cancer Research Center University of Washington Seattle, Washington, USA Reprint requests and correspondence: Brian J Reid, MD, Fred Hutchinson Cancer Research Center, GI Oncology—C1-015, 1100 Fairview Avenue North, Seattle, WA 98109-1024. Received Feb. 5, 2001; accepted Feb. 14, 2001.
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers (2005)

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it is not the sole factor, and evidence is accumulating that EGFR gene amplification, other members of the EGFR family (HER2, HER3) and genes downstream of EGFR signaling (KRAS, BRAF), may be involved in cancer pathogenesis and the response of TKIs. EGFR mutations occur in highly selected subpopulations of lung cancer patients: adenocarcinoma histology, never-smoker status, East Asian ethnicity and female gender. The recent finding of "a resistance associated" mutation for TKIs also provides new insights into this complicated mechanism. Thus, molecular-based studies to analyze the biological functions and to assess TKI sensitivity depending on the type of mutations are required. Epidemiological studies to identify possible carcinogenic factor(s) affecting different subpopulations are also of interest. In addition, for optimal therapeutic approach a comprehensive understanding of the genes related to EGFR signaling pathway, including RAS/RAF/MAPK and PI3K-AKT pathways, are required.
Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems (2004)

Ansel's pharmaceutical dosage forms and drug delivery systems , Ansel's pharmaceutical dosage forms and drug delivery systems , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
Doing It Now or Later (1999)

We examine self-control problems—modeled as time-inconsistent, present-biased preferences—in a model where a person must do an activity exactly once. We emphasize two distinctions: Do activities involve immediate costs or immediate rewards, and are people sophisticated or naive about future self-control problems? Naive people procrastinate immediate-cost activities and preproperate—do too soon—immediate-reward activities. Sophistication mitigates procrastination, but exacerbates preproperation. Moreover, with immediate costs, a small present bias can severely harm only naive people, whereas with immediate rewards it can severely harm only sophisticated people. Lessons for savings, addiction, and elsewhere are discussed. (JEL A12, B49, C70, D11, D60, D74, D91, E21)
Enzymatic Breakage and Joining of Deoxyribonucleic Acid (1968)

Polynucleotide ligase from Escherichia coli infected with bacteriophage T4 catalyzes the esterification of interrupted phosphodiester bonds (single strand breaks) within a DNA duplex. Purified preparations of the enzyme also catalyze an isotopic exchange reaction between ATP and 32PPi. However, they do not catalyze a measurable exchange between 3H-AMP and ATP. A radioactively labeled ligaseAMP complex has been isolated by gel filtration and its properties have been studied. Although purified preparations of polynucleotide ligase require ATP for the esterification of interrupted phosphodiester bonds in a DNA substrate, preparations of ligase-AMP can form phosphodiester bonds in the absence of added ATP. Release of AMP occurs during this reaction and is dependent on the presence of 5′-phosphomonoesters at single strand breaks in the DNA duplex. The extent of the release of AMP is proportional to the number of internal 5′-phosphomonoesters present in the reaction mixture. Native T7 DNA, denatured DNA, sonically treated DNA, and DNA containing only 5′-hydroxyl end groups produce little, if any, ligase-AMP breakdown. The DNA-dependent breakdown of the ligase-AMP complex provides a sensitive method for determining the number of internal 5′-phosphomonoesters in preparations of duplex DNAs.
Vitreous Levels of Vascular Endothelial Growth Factor and Stromal-DerivedFactor 1 in Patients With Diabetic Retinopathy and Cystoid Macular Edema Beforeand After Intraocular Injection of Triamcinolone (2004)

Triamcinolone administration resulted in dramatic reductions of VEGF and SDF-1 to nearly undetectable levels, eliminated DME, and caused regression of active NV. Our results support a role for SDF-1 and VEGF in the pathogenesis of the adverse visual consequences of DR and suggest that the elimination of DME with regression and/or initiation of fibrosis of NV after triamcinolone injection may be due to the suppression of VEGF and SDF-1.
Confirmation of the mapping assignment of human serum albumin to chromosome 4 using a cloned human albumin gene (1982)

The human albumin locus &lt;i&gt;(ALB&lt;/i&gt;) is assigned to chromosome 4 by hybridization of a cloned human albumin gene (cDNA) probe to genomic DNA’s isolated from a panel of human-rodent somatic cell hybrids.
6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions (2000)

Synthesis of 6-(hydroxyphenyl)imidazo[2,1- b ]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on in vitro neutrophil activation, namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed significant inhibitory effects, in some cases more potent than the parent compound.
Motion planning for autonomous driving with a conformal spatiotemporal lattice (2011)

We present a motion planner for autonomous highway driving that adapts the state lattice framework pioneered for planetary rover navigation to the structured environment of public roadways. The main contribution of this paper is a search space representation that allows the search algorithm to systematically and efficiently explore both spatial and temporal dimensions in real time. This allows the low-level trajectory planner to assume greater responsibility in planning to follow a leading vehicle, perform lane changes, and merge between other vehicles. We show that our algorithm can readily be accelerated on a GPU, and demonstrate it on an autonomous passenger vehicle.
The Nutritional Supplement Chromium(III) Tris(picolinate) Cleaves DNA (1999)

Chromium(III) tris(picolinate) [Cr(pic)3] is currently a very popular nutritional supplement; however, its safety has recently been questioned, especially with regard to its ability to act as a clastogen. At physiologically relevant concentrations, Cr(pic)3 is reduced by biological reductants, including ascorbate and thiols, to Cr(II)-containing species. These species are susceptible to air oxidation, resulting in the catalytic generation of the potent DNA-damaging agent hydroxyl radical. In the absence of reductants, H2O2 can interact with Cr(pic)3 to produce hydroxyl radicals by a second, less efficient mechanism. Cr(pic)3 is extremely stable, which allows the complex to be readily absorbed but also to potentially be incorporated into cells intact. In this form, Cr(pic)3 is primed by its redox potential to enter into the generation of hydroxyl radicals. This study suggests that investigation of the long-term effects of supplementation of the diet with Cr(pic)3 are needed to assess the safety of this material.
The radiation improvement of polyethylene prostheses. A preliminary study (1978)

The radiation crosslinking of high-density polyethylene prostheses was investigated over a wide range of doses in the presence and absence of gaseous crosslinking agents. It was found that in the bulk polymer the crosslinking pattern is completely different from the homogeneous crosslinking that occurs in polymer films. The presence of crosslinking agents causes highly crosslinked polymer to be formed on the surface while the bulk of the polymer is largely unaffected--which is explained in terms of diffusion phenomena. This surface crosslinking has a profound effect on the mechanical properties of the prostheses and restricts cold flow and deformation of the polymer without sacrificing the excellent abrasion-resistance properties of the polyethylene when subjected to high pressures. Based on this research a number of high-density polyethylene knee prostheses have been radiation-crosslinked and the results in vitro appear to be very promising.
Ion-beam-assisted deposition of thin films (1983)

Some effects on the properties of electron-beam evaporated thin films produced by ion bombardment of the growing film are reported. Substantial increases in the packing densities of SiO2 , TiO2 , and ZrO2 films have been produced as measured by the reduction in the adsorption of moisture when the films are exposed to a humid atmosphere. In a ZrO2-SiO2 multilayer interference filter, changes in the wavelength of the peak transmittance on exposure to the atmosphere have been reduced from 8 nm for films deposited without ion bombardment to <1 nm for ion-beam-assisted films.
Eigenfaces for Recognition (1991)

We have developed a near-real-time computer system that can locate and track a subject's head, and then recognize the person by comparing characteristics of the face to those of known individuals. The computational approach taken in this system is motivated by both physiology and information theory, as well as by the practical requirements of near-real-time performance and accuracy. Our approach treats the face recognition problem as an intrinsically two-dimensional (2-D) recognition problem rather than requiring recovery of three-dimensional geometry, taking advantage of the fact that faces are normally upright and thus may be described by a small set of 2-D characteristic views. The system functions by projecting face images onto a feature space that spans the significant variations among known face images. The significant features are known as "eigenfaces," because they are the eigenvectors (principal components) of the set of faces; they do not necessarily correspond to features such as eyes, ears, and noses. The projection operation characterizes an individual face by a weighted sum of the eigenface features, and so to recognize a particular face it is necessary only to compare these weights to those of known individuals. Some particular advantages of our approach are that it provides for the ability to learn and later recognize new faces in an unsupervised manner, and that it is easy to implement using a neural network architecture.
Pre- and Post-Treatment Serum Levels of Cytokines IL-1β, IL-6, and IL-1 Receptor Antagonist in Celiac Disease. Are They Related to the Associated Osteopenia? (1998)

Our data demonstrate that the inflammatory process observed in active celiac disease is associated with high serum levels of IL-1beta and IL-6 and normal levels of IL-1-RA. Treatment significantly reduces both proinflammatory cytokines and significantly increases the antiinflammatory one. We also suggest that these cytokines might have a role in the osteopenia associated with celiac disease.
Immune Modulation by Silencing IL-12 Production in Dendritic Cells Using Small Interfering RNA (2003)

RNA interference is a mechanism of posttranscriptional gene silencing that functions in most eukaryotic cells, including human and mouse. Specific gene silencing is mediated by short strands of duplex RNA of approximately 21 nt in length (termed small interfering RNA or siRNA) that target the cognate mRNA sequence for degradation. We demonstrate here that RNAi can be used for immune modulation by targeting dendritic cell (DC) gene expression. Transfection of DC with siRNA specific for the IL-12 p35 gene resulted in potent suppression of gene expression and blockade of bioactive IL-12 p70 production without affecting unrelated genes or cellular viability. Inhibition of IL-12 was associated with increased IL-10 production, which endowed the DC with the ability to stimulate production of Th2 cytokines from allogenic T cells in vitro. Furthermore, siRNA-silenced DC lacking IL-12 production were poor allostimulators in MLR. IL-12-silenced and KLH-pulsed DC polarized the immune response toward a Th2 cytokine profile in an Ag-specific manner. These data are the first to demonstrate that RNA interference is a potent and specific tool for modulating DC-mediated immune responses.
Sensitivity-Enhanced CMOS Phase Luminometry System Using Xerogel-Based Sensors (2009)

We present the design and implementation of a phase luminometry sensor system with improved and tunable detection sensitivity achieved using a complementary metal-oxide semiconductor (CMOS) integrated circuit. We use sol-gel derived xerogel thin films as an immobilization media to house oxygen (O2) responsive luminescent molecules. The sensor operates on the principal of phase luminometry wherein a sinusoidal modulation signal is used to excite the luminophores encapsulated in the porous xerogel films and the corresponding phase shift of the emission signals is monitored. The phase shift is directly related to excited state lifetimes of the luminophores which in turn are related to the concentration of the target analyte species present in the vicinity of the luminophores. The CMOS IC, which consists of a 16 times 16 high-gain phototransistor array, current-to-voltage converter, amplifier and tunable phase shift detector, consumes an average power of 14 mW with 5-V power supply operating at a 38-kHz modulation frequency. The output of the IC is a dc voltage that corresponds to the detected luminescence phase shift with respect to the excitation signal. As a prototype, we demonstrate an oxygen sensor system by encapsulating the luminophore tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) within the xerogel matrices. The sensor system showed a fast response on the order of few seconds and we obtained a detection sensitivity of 118 mV per 1% change in O2 concentration. The system demonstrates a novel concept to tune and improve the detection sensitivity for specific concentrations of the target analyte in many biomedical monitoring applications.
Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation (2009)

A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteobacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients (2004)

Taken together, our results suggest that HIF2 expression may play an important role in angiogenesis and that the combined expression of HIF1 and HIF2 may play an important role in tumor progression and prognosis of colorectal carcinomas. Therefore, HIF expression could be a useful target for therapeutic intervention.
Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. (1998)

Fas ligand (FasL) gene expression is critically involved in peripheral T cell tolerance and lymphocyte homeostasis. Previous studies have suggested that nuclear translocation of NF-kappaB during T cell activation is a critical event for FasL gene activation. In the present study we have identified two NF-kappaB sites (designated FasL-kappaB1 and FasL-kappaB2) on the promoter (approximately 700 bp) of FasL. The NF-kappaB sites were identified by electrophoretic mobility shift assay. Transient transfection reporter analyses showed that the FasL promoter activity was comparable between a construct that contains both sites and a shorter construct (433 bp) that contains only the FasL-kappaB1 site. Furthermore, elimination of FasL-kappaB1 by site-directed mutagenesis significantly inhibited FasL promoter activity. These observations provide strong evidence that NF-kappaB directly binds to the FasL-kappaB1 site and up-regulates FasL gene expression.
Nucleotide sequence and genomic organization of feline immunodeficiency virus. (1989)

An infectious molecular clone of the Petaluma strain of feline immunodeficiency virus (FIV) was isolated from a recombinant bacteriophage library containing genomic DNA prepared from FIV-infected Crandall feline kidney (CRFK) cells. The integrated provirus has a total length of 9472 base pairs. Three long open reading frames corresponding to GAG, POL, and ENV gene coding frames are evident. In addition, an open reading frame overlaps the 3' end of POL, in the region that encodes viral infectivity factor in the primate viruses. Several short open reading frames are present in the intergenic region between POL and ENV and within ENV, which may serve as exons for production of TAT and REV equivalents in FIV. Alignment of the predicted amino acid sequences of the FIV proteins with those of other lentiviruses indicates that FIV did not arise recently from any other characterized lentivirus.
Food for thought (1992)

Further to the article "Infrared imaging feels the heat in microwave ovens", (August p21) it seems likely that the idea of using RF energy to cook food must have occurred to people working on centimetric radar during the Second World War. Perhaps some "boffin" even hung his morning bun in front of an open waveguide and quickly discovered that the warmed bun contained red-hot carbonised culinary currants.