gebhart/patrepeval huggingface dataset:
Reading the Fine print from Orbit: Its Not Just about the Resolution (2008)

This study demonstrates for the first time the therapeutic effect of apigenin in chronic obese asthma and further clarifies its potential therapeutic targets. In addition, this study clarifies the specificity of chronic obese asthma and provides new options for its treatment.
Recently approved systemic therapies for acne vulgaris and rosacea. (2007)

Until recently, with the exception of oral isotretinoin for the treatment of severe recalcitrant nodular acne, systemic therapy for acne vulgaris and rosacea has been based on anecdotal support, clinical experience, and small clinical trials. Tetracycline derivatives are the predominant systemic agents that have been used for both disease states, prescribed in dose ranges that produce antibiotic activity. Anti-inflammatory dose doxycycline, a controlled-release (CR) 40-mg capsule formulation of doxycycline that is devoid of antibiotic activity when administered once daily, was US Food and Drug Administration (FDA)-approved for the treatment of inflammatory lesions (papules and pustules) of rosacea, based on large-scale phase 3 pivotal trials and long-term microbiologic and safety data. Also, an extended-release (ER) tablet formulation of minocycline was approved by the FDA for the treatment of inflammatory lesions of moderate to severe acne vulgaris in patients 12 years and older based on large-scale phase 3 clinical trials that evaluated efficacy and safety, dose-response analysis, and long-term data. This article discusses the studies and clinical applications related to the use of these agents.
Cloning and Functional Expression of a Human Eosinophil CC Chemokine Receptor (1995)

Eosinophils undergo chemotaxis, degranulate, and exhibit [C2+]i changes in response to the human CC chemokines macrophage inflammatory protein (MIP)-1 alpha, regulated on activation, normal T expressed and secreted (RANTES), and monocyte chemoattractant protein-3 (MCP-3), but the receptors involved have not been defined. We have isolated a human cDNA encoding the first eosinophil-selective chemokine receptor, designated CC chemokine receptor 3 (CC CKR3). CC CKR3 is a seven-transmembrane domain G protein-coupled receptor most closely related to the previously reported monocyte- and neutrophil-selective receptor CC CKR1 (also known as the MIP-1 alpha/RANTES receptor). When [Ca2+]i changes were monitored in stably transfected human embryonic kidney 293 cells, MIP-1 alpha and RANTES were both potent agonists for CC CKR3 and CC CKR1. However, MIP-1 beta was also an agonist for CC CKR3 but not CC CKR1; MCP-3 was an agonist for CC CKR1 but not CC CKR3. CC CKR3 may be one of the host factors responsible for selective recruitment of eosinophils to sites of inflammation.
Cell-free cloning using multiply-primed rolling circle amplification with modified RNA primers (2009)

The predominant method for DNA cloning is by propagation in biological hosts, but this method has limitations because certain sequences are difficult to clone using any combination of available hosts or vectors. Recently, multiply-primed rolling circle amplification (MPRCA) has been applied to overcome the problems of the DNA cloning via host cells. However, when MPRCA is used to amplify from minute quantities of DNA template, the products are mostly by-product DNA molecules generated by false priming and primer dimer formation. This study demonstrates that MPRCA using random RNA primers[#x02014]instead of DNA primers[#x02014]blocked the synthesis of by-products and succeeded in amplifying one copy of a circular DNA molecule more than 1012-fold to give microgram quantities of amplification product without using submicroliter reaction volumes. Furthermore, a ligation strategy was elaborated to circularize only the desired DNA sequence and eliminate undesired ligation-products. A combination of these methods was able to amplify and ligate a large construct without undesired DNA sequences and at microgram quantities within one day. Therefore, these methods have the possibility to improve DNA cloning techniques that have been restricted by the limitations of PCR methods or by the host cell.
Gene Designer: a synthetic biology tool for constructing artificial DNA segments (2006)

Gene Designer is an expandable Synthetic Biology workbench suitable for molecular biologists interested in the de novo creation of genetic constructs.
ZD1839, a Selective Oral Epidermal Growth Factor Receptor–Tyrosine Kinase Inhibitor, Is Well Tolerated and Active in Patients With Solid, Malignant Tumors: Results of a Phase I Trial (2002)

ZD1839 was well tolerated, with DLT observed at a dose well above that at which antitumor activity was seen. Pharmacokinetic analysis confirmed that ZD1839 was suitable for administration as a once-daily oral tablet formulation. Phase II monotherapy and phase III combination trials in NSCLC are being conducted to investigate further the efficacy, tolerability, and optimal daily dose of ZD1839.
Molecular characterization and functional analysis of a Flowering locus T homolog gene from a Phalaenopsis orchid (2014)

Warm day and cool night conditions significantly induce reproductive spike formation in Phalaenopsis plants; hence, determining the flowering mechanism regulating the reproductive transition is important. Flowering locus T (FT) plays important roles in flowering induction in several plants. To explore spike induction by warm days and cool nights in Phalaenopsis orchids, we isolated the FT (PhFT) from Phalaenopsis hybrid Fortune Saltzman. The cDNA of PhFT was 809-bp long and contained a 531-bp open reading frame encoding a putative protein of 176 amino acids, a 58-bp 5'-untranslated region (UTR), and a 220-bp 3'-UTR. The predicted molecular mass of PhFT was 19.80 kDa, with an isoelectric point of 8.68. The PhFT was predicted to possess the conserved functional regions of the phosphatidylethanolamine-binding protein superfamily. Nucleotide sequence data indicated that PhFT contained 3 introns and 4 exons. Sequence alignment and phylogenetic analyses of PhFT revealed high homology to the FT proteins of Cymbidium goeringii and Oncidium Gower Ramsey. Quantitative real-time polymerase chain reaction analysis indicated that PhFT mRNA was expressed in roots, apical leaves, mature leaves, and flowers. In flowers, PhFT was expressed more in developing floral buds than in mature flowers and was predominantly expressed in ovaries and petals. Ectopic expression of PhFT in Arabidopsis ft-1 mutants showed novel early-flowering phenotypes that lost their siliques. Our results indicated that the ectopic expression of PhFT could partially complement the late flowering defect in transgenic Arabidopsis ft-1 mutants. Our findings suggest that PhFT is a putative FT homolog in Phalaenopsis plants that regulates flowering transition.
Cognitive hacking: a battle for the mind (2002)

On 25 August 2000, stockholders were stunned by news that server and storage provider Emulex was revising its earnings from a per-share gain to a loss, while lowering its reported net earnings from the previous quarter as well. Within minutes, Emulex shares plummeted. Yet none of this news fostered by a hacker's bogus press release - was true. The Emulex case illustrates the speed, scale, and subtlety with which networked information can propagate and how quickly severe consequences can occur. This rapid dissemination, which makes such cognitive hacking possible, is forcing security researchers to look at yet another class of countermeasures - a class far different from solutions that seek to secure technology and network infrastructure.
Synthesis and application of inorganic/organic composite materials (1996)

Abstract A new type of inorganic‐organic composite has been developed using organic monomeric or polymerizable silanes (with appropriate organic groupings like double bonds or epoxides) as monomers or in situ prepared or separately added nano‐scale ceramic or metal particles. Due to the small size of the particulate phase, these composites are still highly transparent but show properties at least partially to be attributed to the inorganic phase. The introduction of special functions into these materials has been used for the fabrication of interesting functions like non‐linear optical properties, low surface free energy coatings, controlled release properties or special mechanical properties (scratch resistance).
An FPGA-based hardware emulator for fast fault emulation (2002)

An FPGA-based hardware emulation system is shown to boost the speed of fault simulation for sequential circuits. The circuit is downloaded into the emulation system which emulates the faulty circuit's behavior by synthesizing from the good circuit and the given fault list in a novel way. Fault injection is made easy by shifting the content of a fault injection chain, with which we get rid of the highly time-consuming bit-stream regeneration process. Experimental results for ISCAS-89 benchmark circuits show that the fault emulator is about twenty times faster than HOPE (parallel fault simulator). A parallel fault emulation approach is also proposed, in which faults that are not activated or with short propagation distance are screened off before fault emulation, and non-stem faults are collapsed into their equivalent stem faults, further reducing the number of faults actually emulated.
Invasive Streptococcus pneumoniae infection associated with rapidly fatal outcome in Taiwan. (1996)

We observed 42 cases of invasive Streptococcus pneumoniae infections from 1991 through 1993 in southern Taiwan. The antimicrobial susceptibilities and distribution of serotypes of the 42 isolates from these invasive infections were determined. Serotypes 14, 3, 6, 23, 15 and 4 were most commonly identified. Serotypes 14 and 6 most frequently caused infections in pediatric patients, while serotypes 3, 14 and 23 were commonly encountered in adults. Overall, 85.7% of the isolates were included in the serotypes represented in the 23-valent pneumococcal vaccine. Three isolates were intermediately resistant to penicillin and none were fully resistant. Resistance rates were: erythromycin, 61.9%; clindamycin, 47.6%; chloramphenicol, 19%; and tetracycline, 73.8%. Resistance to three or more classes of antibiotics was found in 33.3% of the isolates, in which the majority were serotypes 14 and 6 and nontypeable isolates. Bacteremic pneumonia and primary bacteremia accounted for 64.3% of the infections. Mortality was 42.6%. Factors associated with higher mortality included age of > 16 years, the presence of underlying diseases, development of one or more septic complications, bacteremic pneumonia and the presence of serotype 3 isolates. Rapidly fatal outcome (the illness developed less than 48 hours prior to admission and the death occurred within 48 hours of hospitalization) occurred in 12 (66.7%) of the 18 patients who died. All these patients received adequate antibiotic treatment and aggressive intensive care, indicating the fulminant nature of this infection. Mucoid serotype 3 isolates caused rapidly fatal outcomes. Given the severity of these infections despite adequate antibiotic therapy and the vulnerability of patients with altered immune responses, there is a dire need for introduction of new therapeutic options and preventive measures to prevent mortality due to invasive S. pneumoniae infections.
Elastic properties of zinc-blende and wurtzite AlN, GaN, and InN (1997)

Elastic constants for zinc-blende and wurtzite AlN, GaN, and InN are obtained from density-functional-theory calculations utilizing ab initio pseudopotentials and plane-wave expansions. Detailed comparisons are made with the available measured values and with results obtained in previous theoretical studies. These comparisons reveal clear discrepancies between the different sets of elastic constants which are further highlighted by examining derived quantities such as the perpendicular strain in a lattice-mismatched epitaxial film and the change in the wurtzite c/a ratio under hydrostatic pressure. Trends among results for the three compounds are also examined as well as differences between results for the zinc-blende and wurtzite phases.
A Simple Energy Recovery Circuit for High-Power Inverters With Complete Turn-On and Turn-Off Snubbers (2004)

This paper presents and analyzes an active energy recovery circuit for the inductive turn-on snubber and capacitive turn-off snubber used on high-power gate-turn-off thyristor inverters. The circuit performs as a simple switched-mode power supply and recovers the inductive and capacitive snubbers energy induced in power inverters back into the dc rail with the aid of an extra switch. The features and operation of the proposed circuit are given and supported by PSpice simulations and experimental results.
NMR characterization of lignins in Arabidopsis altered in the activity of ferulate 5-hydroxylase (1999)

Nuclear magnetic resonance (NMR) of isolated lignins from an Arabidopsis mutant deficient in ferulate 5-hydroxylase (F5H) and transgenic plants derived from the mutant by overexpressing the F5H gene has provided detailed insight into the compositional and structural differences between these lignins. Wild-type Arabidopsis has a guaiacyl-rich, syringyl-guaiacyl lignin typical of other dicots, with prominent beta-aryl ether (beta-O-4), phenylcoumaran (beta-5), resinol (beta-beta), biphenyl/dibenzodioxocin (5-5), and cinnamyl alcohol end-group structures. The lignin isolated from the F5H-deficient fah1-2 mutant contained only traces of syringyl units and consequently enhanced phenylcoumaran and dibenzodioxocin levels. In fah1-2 transgenics in which the F5H gene was overexpressed under the control of the cauliflower mosaic virus 35S promoter, a guaiacyl-rich, syringyl/guaiacyl lignin similar to the wild type was produced. In contrast, the isolated lignin from the fah1-2 transgenics in which F5H expression was driven by the cinnamate 4-hydroxylase promoter was almost entirely syringyl in nature. This simple lignin contained predominantly beta-aryl ether units, mainly with erythro-stereochemistry, with some resinol structures. No phenylcoumaran or dibenzodioxocin structures (which require guaiacyl units) were detectable. The overexpression of syringyl units in this transgenic resulted in a lignin with a higher syringyl content than that in any other plant we have seen reported.
SYNTHESIS OF UNNATURAL 7-SUBSTITUTED-1-(2-DEOXY-β-D-RIBOFURANOSYL)ISOCARBOSTYRILS†: “THYMINE REPLACEMENT” ANALOGS OF DEOXYTHYMIDINE FOR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS (2001)

A group of unnatural 1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils having a variety of C-7 substituents [H, 4,7-(NO2)2, I, CF3, CN, (E)-CH=CH-I, -C triple bond CH, -C triple bond C-I, -C triple bond C-Br, -C=C-Me], designed as nucleoside mimics, were synthesized for evaluation as anticancer and antiviral agents. This class of compounds exhibited weak cytotoxicity in a MTT assay (CC50 = 10(-3) to 10(-5) M range) with the 4,7-dinitro derivative being the most cytotoxic, relative to thymidine (CC50 = 10(-3) to 10(-5) M range), against a variety of cancer cell lines. The 4,7-dinitro, 7-I and 7-C triple bond CH compounds exhibited similar cytotoxicity against non-transfected (KBALB, 143B), and HSV-1 TK+ gene transfected (KBALB-STK, 143B-LTK) cancer cell lines possessing the herpes simplex virus type 1 (HSV-1) thymidine kinase gene (TK+). This observation indicates that these compounds are not substrates for HSV type-1 TK, and are therefore unlikely to be useful in gene therapy based on the HSV gene therapy paradigm.
Phase I Trial of Multiple Large Doses of Murine Monoclonal Antibody CO17-1A. I. Clinical Aspects1 (1988)

Twenty-five patients with metastatic gastrointestinal adenocarcinoma received one to four infusions (400 mg) of murine monoclonal antibody CO17-1A. Eleven patients had mild gastrointestinal symptoms, and one had a transient flushing episode. Two of five who received three weekly infusions had readily reversible anaphylactic reactions at the time of the third infusion (day 15). There were no other toxic effects. One patient had a complete remission and is surviving at greater than 104 weeks, and four had stable disease. The median survival for the whole group was 57 weeks. In general, the antibody infusions were well tolerated but had modest antitumor effects.
A Multi-objective Incremental Path Planning Algorithm for Mobile Agents. (2012)

Path planning is a crucial issue in unknown environments where an autonomous mobile agent has to reach a particular destination from some initial location. There are several incremental algorithms such as D* [1], D* Lite [2] that are able to ensure reasonable paths in terms of path length in unknown environments. However, in many real-world problems we realize that path length is not only the sole objective. For example in computer games, a non-player character needs to not only find a minimum cost path to some target location but also minimize threat exposure. This means that path planning/finding activity of an agent in a multi-agent environment has to consider more than one objective to be achieved. In this paper, we propose a new incremental search algorithm called MOD* Lite extending Koenig's D* Lite algorithm and show that MOD* Lite is able to optimize path quality in more than one criteria that cannot be transformed to each other. Experimental results show that MOD* Lite is able to find optimal solutions and is fast enough to be used in real-world multi-agent applications such as robotics, computer games, or virtual simulations.
Nuclear Receptors and the Hormonal Regulation ofDrosophilaMetamorphosis (1999)

The steroid hormone ecdysone regulates the major post-embryonic transitions during the Drosophila life cycle, including the onset of, and progression through, metamorphosis. Reviewed here are several recent studies that together give insight into both the transduction of the ecdysone signal itself as well as other possible hormonal signaling events associated with metamorphosis. Genetic studies of the two components of the ecdysone receptor, EcR and usp, demonstrate that they are essential for the initiation of metamorphosis in Drosophila. These genes are not, however, required for some earlier events that prepare the animal for metamorphosis. Instead, the orphan nuclear receptor DHR78 appears to regulate these events, possibly in response to an as yet unidentified hormone. An additional role for usp, independent from EcR function, has also been uncovered in epidermis and cuticle development, suggesting a possible role for usp in integrating ecdysone and juvenile hormone signals.
Comparative measurements of inverse spin Hall effects and magnetoresistance in YIG/Pt and YIG/Ta (2013)

We report on a comparative study of spin Hall related effects and magnetoresistance in YIG$|$Pt and YIG$|$Ta bilayers. These combined measurements allow to estimate the characteristic transport parameters of both Pt and Ta layers juxtaposed to yttrium iron garnet (YIG): the spin mixing conductance ${G}_{\ensuremath{\uparrow}\ensuremath{\downarrow}}$ at the YIG$|$normal metal interface, the spin Hall angle ${\ensuremath{\Theta}}_{\mathrm{SH}}$, and the spin diffusion length ${\ensuremath{\lambda}}_{\mathrm{sd}}$ in the normal metal. The inverse spin Hall voltages generated in Pt and Ta by the pure spin current pumped from YIG excited at resonance confirm the opposite signs of spin Hall angles in these two materials. Moreover, from the dependence of the inverse spin Hall voltage on the Ta thickness, we extract the spin diffusion length in Ta, found to be ${\ensuremath{\lambda}}_{\mathrm{sd}}^{\mathrm{Ta}}=1.8\ifmmode\pm\else\textpm\fi{}0.7$ nm. Both the YIG$|$Pt and YIG$|$Ta systems display a similar variation of resistance upon magnetic field orientation, which can be explained in the recently developed framework of spin Hall magnetoresistance.
Alkyl 3,7,11-trimethyl-2,4-dodecadienoates, a new class of potent insect growth regulators with juvenile hormone activity (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkyl 3,7,11-trimethyl-2,4-dodecadienoates, a new class of potent insect growth regulators with juvenile hormone activityClive A. Henrick, Gerardus B. Staal, and John B. SiddallCite this: J. Agric. Food Chem. 1973, 21, 3, 354–359Publication Date (Print):May 1, 1973Publication History Published online1 May 2002Published inissue 1 May 1973https://pubs.acs.org/doi/10.1021/jf60187a043https://doi.org/10.1021/jf60187a043research-articleACS PublicationsRequest reuse permissionsArticle Views288Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Three‐dimensional computed tomographic reconstruction using a C‐arm mounted XRII: Image‐based correction of gantry motion nonidealities (2000)

The image quality of 3D reconstructions produced using a C-arm mounted XRII depends on precise determination of the geometric parameters that describe the detector system in the laboratory frame of reference. We have designed a simplified calibration system that depends on images of a metal sphere, acquired during rotation of the gantry through 200 degrees. Angle-dependent shift corrections are obtained, accounting for nonideal motion in two directions: perpendicular to the axis of rotation and tangential to the circular trajectory (tau), and parallel to the axis of rotation (xi). Projection images are corrected prior to reconstruction using a simple shift-interpolation algorithm. We show that the motion of the gantry is highly reproducible during acquisitions within one day (mean standard deviation in tau and xi is 0.11 mm and 0.08 mm, respectively), and over 21 months (mean standard deviation in tau and xi is 0.10 mm and 0.06 mm, respectively). Reconstruction of a small-bead phantom demonstrates uniformity of the correction algorithm over the full volume of the reconstruction [standard deviation of full-width-half-maximum of the beads is approximately 0.25 pixels (0.13 mm) over the volume of reconstruction]. Our approach provides a simple correction technique that can be applied when trajectory deviations are significant relative to the pixel size of the detector but small relative to the detector field of view, and when the fan angle of the acquisition geometry is small (<20 degrees). A comparison with other calibration techniques in the literature is provided.