gebhart/patrepeval huggingface dataset:
Why do patients choose to consult homeopaths? An exploratory study : original research (2008)

Background: Patients are using homeopathy in increasing numbers and not telling their doctors about it. It is important as family physicians that we understand the reasons why patients choose to consult homeopaths. It is important to know what our patients are looking for that they do not find in Western medicine. This information will provide valuable insights and enable us to engage with our patients in an informed and empathetic way such engagement being vital to maintaining an open relationship and providing the best possible care and advice. 
Methods: The aim of this study was to understand the reasons why patients choose to consult homeopaths. Eight free-attitude interviews were conducted with purposefully selected patients who consulted a particular homeopath in Gauteng province. The exploratory question was 'Why do you choose to consult a homeopath?'. The interviews were all conducted in English, transcribed verbatim, and analysed for categories and themes using the 'cut and paste' method. Member checks were done by verifying the transcribed data with the interviewees by e-mail. Triangulation of the data was done by audio-recording of the interviews, and using transcribed notes and field notes collected during the interviews. 
Results: All the participants initially consulted a homeopath after their health problems were not solved by mainstream medical treatment. Most were also concerned about the side effects of long-term mainstream medication. Many were frustrated with mainstream consultation or relationship factors, including rushed consultations, being asked too few questions and doctors being too quick to prescribe. Some participants said that doctors had a poor bedside manner, were difficult to talk to, and were judgemental or uncaring. The participants continued to consult homeopaths because they felt that the treatment was effective, natural and did not have side effects. They indicated that homeopathic treatment works with the body and health problems therefore are solved in the long term. This makes homeopathic treatment cheaper, because the same problem does not need to be treated repeatedly. Homeopathic consultations were longer, and homeopaths were easier to talk to and formed an equal partnership with them. In addition, problems were managed holistically mind, emotions and body, as well as work and family factors were considered. Homeopaths were considered competent and ethical and knew their limitations. 
Conclusion: From the reasons given for consulting homeopaths, we, as family physicians, can learn a lot about what patients consider important in their consultations and management. Frustration with some aspect of mainstream care has pushed them to look for solutions elsewhere Much of what the patients did not find with doctors but found with homeopaths can be found in the principles of family medicine. It will be important to validate the findings of this study by developing a hypothesis that can be tested using a quantitative paradigm.
Endotoxin removal by charge-modified filters (1985)

The effects of positively charged nylon and depth (cellulose-diatomaceous earth) filters on endotoxin removal from various solutions were evaluated. The charged filter media removed significant amounts of Escherichia coli and natural endotoxin from tap water, distilled water, sugars, and NaCl solutions; no significant removal of endotoxin was observed with negatively charged filter media. The extent of removal was influenced by pH, the presence of salts, and organic matter. Such media may be useful for the control of endotoxins in raw-product water or solutions used to prepare parenteral drug products or in other fluids where endotoxin control is desired.
Chemical synthesis : gnosis to prognosis (1996)

Preface. Asymmetric Synthesis: I - Fundamentals and Recent Advances. II - Some Aspects of Asymmetric Catalysis with Transition-Metal Complexes H.B. Kagan. Addition of Enolates and Metalloalkyls to Imines. Stereospecific Synthesis of beta-Lactams, Amines, Aziridines and Aminols G. Cainelli, et al. Target-Driven Organic Synthesis: Reflections on the Past, Prospects for the Future S. Hanessian. Optically Active Transition Metal Compounds Containing Chiral Transition Metal Atoms H. Brunner. Biomimetic Chemistry. Bifunctional Binding and Catalysis R. Breslow. Design of Enzyme Inhibitors. Answering Biological Questions Through Organic Synthesis P.A. Bartless. Enantioselective Catalysis with Transition Metal Complexes H. Brunner. Directed Aromatic Metalation: A Continuing Education in Flatland Chemistry V. Snieckus. Panel Discussion I. As We Head Into the 21st Century, is There Still Value in Total Synthesis of Natural Products as a Research Endeavor? C.H. Heathcock. Convergent Strategies for Synthetic Receptors P. Timmerman, et al. The Advancement of Radical-Based Synthetic Strategies: From Reagent Design to Polymer Modification C. Chatgilialoglu. Templated Synthesis of Enzyme Mimics: How Far Can We Go? S. Anderson, J.K.M. Sanders. Towards a Chemical Etiology of the Natural Nucleic Acids' Structure A. Eschenmoser. Principles of Antibody Catalysis D. Hilvert. New Homocalixarenes and Catenanes: From Molecular Recognition to Mechanical Bonds S. Meier, et al. Self-Assembly in Chemical Synthesis S.J. Langford, J.F. Stoddart. Oligonucleotide-Directed Recognition of Double-Helical DNA C. Helene, T. Garestier. Can Enzyme Mimics Compete With Catalytic Antibodies? C.J. Walter, et al. Panel Discussion II. Synthesis of Giant Modular Structures: SupramolecularAssemblies and Well-Defined Macro-Molecules J. Michl. Polymer Synthesis and Stereochemistry with Transition Metal Catalysts R. Waymouth, et al. Making Unnatural Products by Natural Means S.J. Langford, J.F. Stoddart. Supramolecular Chemistry and Chemical Synthesis. From Molecular Interactions to Self-Assembly J.-M. Lehn. Synthetic Approaches to Functional Polymers F. Ciardelli, et al. Transduction of Molecular Interactions into Macroscopic Properties H.C. Visser, et al. Approaches to Synthesis Based on Non-Covalent Bonds G.M. Whitesides, et al. Panel Discussion III. Organic Synthesis and the Life Sciences D. Arigoni. Index.
Comparison of tamsulosin with alfuzosin in the treatment of patients with lower urinary tract symptoms suggestive of bladder outlet obstruction (symptomatic benign prostatic hyperplasia) (1997)

Tamsulosin is the first adrenoceptor antagonist that is selective for the alpha 1 A-subtype; this specificity may explain its lack of effect on blood pressure compared with alfuzosin, an agent that is not receptor subtype specific. Moreover, this finding may partly explain why tamsulosin, in contrast to other currently available alpha 1-adrenoceptor antagonists, can be administered without dose titration. Another advantage compared with alfuzosin (and prazosin) is the once-daily dosing regimen of tamsulosin.
Lightweight detection and classification for wireless sensor networks in realistic environments (2005)

A wide variety of sensors have been incorporated into a spectrum of wireless sensor network (WSN) platforms, providing flexible sensing capability over a large number of low-power and inexpensive nodes. Traditional signal processing algorithms, however, often prove too complex for energy-and-cost-effective WSN nodes. This study explores how to design efficient sensing and classification algorithms that achieve reliable sensing performance on energy-and-cost effective hardware without special powerful nodes in a continuously changing physical environment. We present the detection and classification system in a cutting-edge surveillance sensor network, which classifies vehicles, persons, and persons carrying ferrous objects, and tracks these targets with a maximum error in velocity of 15%. Considering the demanding requirements and strict resource constraints, we design a hierarchical classification architecture that naturally distributes sensing and computation tasks at different levels of the system. Such a distribution allows multiple sensors to collaborate on a sensor node, and the detection and classification results to be continuously refined at different levels of the WSN. This design enables reliable detection and classification without involving high-complexity computation, reduces network traffic, and emphasizes resilience and adaptation to the realistic environment. We evaluate the system with performance data collected from outdoor experiments and field assessments. Based on the experience acquired and lessons learned when developing this system, we abstract common issues and introduce several guidelines which can direct future development of detection and classification solutions based on WSNs.
Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer (2007)

The activating point mutation of the BRAF gene, BRAF(T1799A), is the most common and specific genetic alteration in adult papillary thyroid carcinoma (PTC) and a possible marker of malignant potential of PTC. We have applied the PCR-RFLP method using fine-needle aspiration biopsy samples not only to our clinical practice but also to the international medical assistance effort around the Semipalatinsk Nuclear Testing Site in Kazakhstan. Seventy-seven cases (100 nodules) from Japan and 131 cases (137 nodules) from Kazakhstan were examined. There were 14 Japanese and 76 Kazakhstani cases of cytological malignant tumors from the examined samples. We detected 12 (85.7% of PTC) and 19 (25% of PTC) cases with BRAF(T1799A) among the Japanese and Kazakhstani cases, respectively. Of these cases, we found mutations in one cytologically "suspicious" case and even in two pathologically "benign" cases (after surgery in Kazakhstan). All of the BRAF mutation-positive cases, including those three, were confirmed as PTC by careful pathological examination, including immunohistochemical analysis. In summary, our PCR-RFLP method for BRAF(T1799A) detection using FNAB samples is useful not only for preoperative diagnosis of PTC but also as a complementary diagnostic tool for accurate pathological diagnosis, even after surgery.
Evaluation of a Rapid Immunochromatographic Test for Detection of Streptococcus pneumoniae Antigen in Urine Samples from Adults with Community-Acquired Pneumonia (2001)

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia but is undoubtedly underdiagnosed. Isolation of S. pneumoniae from blood is specific but lacks sensitivity, while isolation of S. pneumoniae from sputum may represent colonization. We evaluated a new immunochromatographic test (NOW S. pneumoniae urinary antigen test; Binax, Portland, Maine) that is simple to perform and that can detect S. pneumoniae antigen in urine within 15 min. Urine samples from 420 adults with community-acquired pneumonia and 169 control patients who did not have pneumonia were tested. Urine from 315 (75%) of the pneumonia patients and all controls was tested both before and after 25-fold concentration, while the remaining 105 samples were only tested without concentration. S. pneumoniae urinary antigen tests were positive for 120 (29%) patients with pneumonia and for none of the controls. Of the urine samples tested with and without concentration, 96 were positive, of which 6 were positive only after concentration. S. pneumoniae antigen was detected in the urine from 16 of the 20 (80%) patients with blood cultures positive for S. pneumoniae and from 28 of the 54 (52%) patients with sputum cultures positive for S. pneumoniae. The absence of S. pneumoniae antigen in the urine from controls suggests that the specificity is high. Concentration of urine prior to testing resulted in a small increase in yield. The NOW S. pneumoniae urinary antigen test should be a useful adjunct to culture for determining the etiology of community-acquired pneumonia in adults.
Hierarchical organization of cognitive memory (1997)

This paper addresses the question of the organization of memory processes within the medial temporal lobe. Evidence obtained in patients with late-onset amnesia resulting from medial temporal pathology has given rise to two opposing interpretations of the effects of such damage on long-term cognitive memory. One view is that cognitive memory, including memory for both facts and events, is served in a unitary manner by the hippocampus and its surrounding cortices; the other is that the basic function affected in amnesia is event memory, the memory for factual material often showing substantial preservation. Recent findings in patients with amnesia resulting from relatively selective hippocampal damage sustained early in life suggest a possible reconciliation of the two views. The new findings suggest that the hippocampus may be especially important for event as opposed to fact memory, with the surrounding cortical areas contributing to both. Evidence from neuroanatomical and neurobehavioural studies in monkeys is presented in support of this proposal.
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis (2004)

Obesity is a risk factor for the development of many severe human diseases such as cardiovascular disorders, diabetes, and cancer, which are tightly linked to angiogenesis. The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis factor alpha, and adiponectin. It has been found that adiponectin levels are reduced in obesity. Here, we report a unique function of adiponectin as a negative regulator of angiogenesis. In vitro, adiponectin potently inhibits endothelial cell proliferation and migration. In the chick chorioallantoic membrane and the mouse corneal angiogenesis assays, adiponectin remarkably prevents new blood vessel growth. Further, we demonstrate that the antiendothelial mechanisms involve activation of caspase-mediated endothelial cell apoptosis. Adiponectin induces a cascade activation of caspases-8, -9, and -3, which leads to cell death. In a mouse tumor model, adiponectin significantly inhibits primary tumor growth. Impaired tumor growth is associated with decreased neovascularization, leading to significantly increased tumor cell apoptosis. These data demonstrate induction of endothelial apoptosis as an unique mechanism of adiponectin-induced antiangiogenesis. Adiponectin, as a direct endogenous angiogenesis inhibitor, may have therapeutic implications in the treatment of angiogenesis-dependent diseases.
Pulse dispersion for single-mode operation of multimode cladded optical fibres (1974)

Pulse dispersions as low as 0.4 ns/km have been measured in multimode cladded fibres at a normalised frequency V=125 and for a constant bend radius of 5.5 cm. Particularly when the number of launched modes is small, the pulse dispersion, as well as the polarisation and angular width of the output beam, are strong functions of the degree of mode conversion.
Endothelial Cell Seeding on Crosslinked Collagen: Effects of Crosslinking on Endothelial Cell Proliferation and Functional Parameters (2000)

Endothelial cell seeding, a promising method to improve the performance of small-diameter vascular grafts, requires a suitable substrate, such as crosslinked collagen. Commonly used crosslinking agents such as glutaraldehyde and formaldehyde cause, however, cytotoxic reactions and thereby hamper endothelialization of currently available collagen-coated vascular graft materials. The aim of this study was to investigate the effects of an alternative method for crosslinking of collagen, using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) in combination with N-hydroxysuccinimide (NHS), on various cellular functions of human umbilical vein endothelial cells (HUVECs) in vitro. Compared to non-crosslinked type I collagen, proliferation of seeded endothelial cells was significantly increased on EDC/NHS-crosslinked collagen. Furthermore, higher cell numbers were found with increasing crosslink densities. Neither the morphology of the cells nor the secretion of prostacyclin (PGI2), von Willebrand factor (vWF), tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) was affected by the crosslink density of the collagen substrate. Therefore, EDC/NHS-crosslinked collagen is candidate substrate for in vivo application such as endothelial cell seeding of collagen-coated vascular grafts.
T Cell Memory in the Context of Persistent Herpes Viral Infections (2012)

The generation of a functional memory T cell pool upon primary encounter with an infectious pathogen is, in combination with humoral immunity, an essential process to confer protective immunity against reencounters with the same pathogen. A prerequisite for the generation and maintenance of long-lived memory T cells is the clearance of antigen after infection, which is fulfilled upon resolution of acute viral infections. Memory T cells play also a fundamental role during persistent viral infections by contributing to relative control and immuosurveillance of active replication or viral reactivation, respectively. However, the dynamics, the phenotype, the mechanisms of maintenance and the functionality of memory T cells which develop upon acute/resolved infection as opposed to chronic/latent infection differ substantially. In this review we summarize current knowledge about memory CD8 T cell responses elicited during α-, β-, and γ-herpes viral infections with major emphasis on the induction, maintenance and function of virus-specific memory CD8 T cells during viral latency and we discuss how the peculiar features of these memory CD8 T cell responses are related to the biology of these persistently infecting viruses.
Extracting clauses for spoken language understanding in conversational systems (2002)

Spontaneous human utterances in the context of human-human and human-machine dialogs are rampant with dysfluencies, and speech repairs. Furthermore, when recognized using a speech recognizer, these utterances produce a sequence of words with no identification of clausal units. Such long strings of words combined with speech errors pose a difficult problem for spoken language parsing and understanding. In this paper, we address the issue of editing speech repairs as well as segmenting user utterances into clause units with a view of parsing and understanding spoken language utterances. We present generative and discriminative models for this task and present evaluation results on the human-human conversations obtained from the Switch board corpus.
Copper efflux transporter (ATP7B) contributes to the acquisition of cisplatin-resistance in human oral squamous cell lines (2007)

Acquired resistance to cisplatin (CDDP) is an issue in cancer chemotherapy. This resistance has been reported to be correlated with the expression of the Cu influx copper transporter 1 (CTR1) and two copper efflux transporters (ATP7A, ATP7B). We investigated the correlation between the expression of these transporters and the sensitivity to CDDP using three pairs of parent cell lines and resistant cell lines derived from various types of invasive oral squamous cell carcinoma (OSCC). Using multiple steps, each of the CDDP-resistant cell lines, HSC-4-R, OSC-19-R, HOC313-R, was selected from HSC-4 cells derived from a cancer with medium invasiveness, OSC-19 cells derived from a cancer with high invasiveness and HOC313 cells derived from a cancer with the highest invasiveness. Resistant cell lines had a stronger expression of ATP7B in conjunction with the acquisition of CDDP-resistance than parent cell lines. Furthermore, OSC-19-R cells transfected with the ATP7B siRNA had a 10.6-fold higher sensitivity to CDDP compared to OSC-19-R cells transfected with a nonsense siRNA. These results suggest that each of the resistant cell lines had acquired resistance to CDDP due to the overexpression of ATP7B. On the other hand, the expression of CTR1 was the same between sensitive cell lines and resistant cell lines and ATP7A mRNA expression was barely noted. We conclude that ATP7B is correlated with the acquisition of CDDP resistance more closely than either CTR1 or ATP7A. ATP7B may be a key determinant in the acquired resistance to CDDP in OSCC.
Membrane attack induced by HlyA, a pore-forming toxin of Vibrio cholerae (1997)

Determining the activity of purified toxins has generally provided the basis for establishing their role in the host-pathogen relationship. The bacterial genus Vibrio produces a number of exotoxins in addition to cholera toxin, including haemolysin A (HlyA; Vibrio cholerae) and thermostable direct haemolysin (TDH; Vibrio parahaemolyticus), both of which possess membrane-targeting cytolytic activity. The action of HlyA has been analyzed using protocols previously applied to TDH: lysis and flux experiments on human erythrocytes showed that HlyA similarly causes lysis after cell swelling (by colloid osmosis) due to an elevation of cation permeability. However, kinetic measurements of flux, haemolysis and cation selectivity showed that HlyA and TDH form pores with distinct and characteristic features.
Reflection properties of the Salisbury screen (1988)

The reflection properties of multiple electric/magnetic Salisbury screens have been studied. Analytical formulae are developed for the maximally flat design of two- and three-screen planar stackups that have taken into account appropriate values for the spacer materials used to separate the screens. The effect of curvature has also been assessed. It is shown that relatively large reductions in specular reflection are possible over sizeable bandwidths using relatively few Salisbury screens. Furthermore, these reductions are not completely destroyed if the incident wave is not normal to the surface, if the surface is curved or if there are errors in fabrication of the screen.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature (2012)

The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.
A tale of migration to cloud computing for sharing experiences and observations (2011)

Cloud computing is an emerging paradigm, which promises to make the utility computing model comprehensively implemented by using virtualization technologies. An increasing number of enterprises have started providing and using Cloud-enabled infrastructures and services. However, the advancement of cloud computing poses several new challenges to existing methods and approaches to develop and evolve software intensive systems. This paper reports our experiences and observations gained from migrating an Open Source Software (OSS), Hackystat, to cloud computing. We expect that our description of Hackystat's architecture prior and after migration and design decisions can provide some guidance about modifying architecture of a service-based system for cloud computing. Moreover, we also hope that our experiences reported in this paper can contribute to the identification of some research questions for improving software engineering support for developing and evolving cloud-enabled systems.