gebhart/patrepeval huggingface dataset:
Cardiac Changes during 2-Deoxy-<i>D</i>-Glucose Test (1975)

2-Deoxy-D-glucose (2-DG), a potent vagal stimulator, is used for testing the completeness of surgical vagotomies. 2-DG has however not yet been employed routinely for the postoperative testing of bagotomized patients because of possible cardiotoxic effects. In a previous study, we have shown the effects of 2-DG on the resting ECG in 48 patients. We did not observe any significant changes besides nonspecific T wave flattening and QT prolongation. The present investigation included 37 additional patients. In 27 patients, a continuous ECG tape recording for detection of arrhythmias was performed and in 10 patients, the systolic time intervals for non-invasive assessment of the myocardial contractility was recorded before and after 2-DG. Serious arrhythmias were not provoked by 2-DG. Premature contractions were, as a whole, not incrased by the drug. 2-DG did not have any cardiodepressive action. On the contrary myocardial contractility evaluated by the systolic time intervals was enhanced.
Transmission Power Control in Body Area Sensor Networks for Healthcare Monitoring (2009)

This paper investigates the opportunities and challenges in the use of dynamic radio transmit power control for prolonging the lifetime of body-wearable sensor devices used in continuous health monitoring. We first present extensive empirical evidence that the wireless link quality can change rapidly in body area networks, and a fixed transmit power results in either wasted energy (when the link is good) or low reliability (when the link is bad). We quantify the potential gains of dynamic power control in body-worn devices by benchmarking off-line the energy savings achievable for a given level of reliability.We then propose a class of schemes feasible for practical implementation that adapt transmit power in real-time based on feedback information from the receiver. We profile their performance against the offline benchmark, and provide guidelines on how the parameters can be tuned to achieve the desired trade-off between energy savings and reliability within the chosen operating environment. Finally, we implement and profile our scheme on a MicaZ mote based platform, and also report preliminary results from the ultra-low-power integrated healthcare monitoring platform we are developing at Toumaz Technology.
Some Derivatives of Phenothiazine (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Derivatives of PhenothiazineHenry Gilman and David A. ShirleyCite this: J. Am. Chem. Soc. 1944, 66, 6, 888–893Publication Date (Print):June 1, 1944Publication History Published online1 May 2002Published inissue 1 June 1944https://doi.org/10.1021/ja01234a013RIGHTS & PERMISSIONSArticle Views650Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (793 KB) Get e-Alerts Get e-Alerts
Comparison of two three-dimensional x-ray cone-beam-reconstruction algorithms with circular source trajectories (1991)

We compare two algorithms of three-dimensional (3D) cone-beam tomography: a 3D backprojection algorithm and a Radon algorithm, with a circular source trajectory. We recall the principle of these algorithms and show that when the source trajectory is circular, an exact reconstruction cannot be performed. We evaluate structures that cannot be detected and show that, for each algorithm, assumptions must be made about the object to estimate the missing information. Using simulated data, we measured the modulation transfer function of the two algorithms, evaluated the density resolution, and measured the artifacts due to missing information. We show that the 3D backprojection algorithm has good geometrical resolution along the axis of rotation and that, from the standpoint of density resolution, its useful limit is ±3°. We also show that it is sensitive to the lack of information in the horizontal planes. The useful aperture of the Radon algorithm is ±12°; for apertures lower than this limit, the algorithm is much less sensitive to the lack of information in the horizontal planes than the 3D backprojection algorithm. We present two examples of reconstructions that illustrate the limitations of these algorithms when applied to realistic samples and discuss the limits of using each algorithm when the source trajectory is circular.
Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors (1973)

The number of acetylcholine receptors was determined in the neuromuscular junctions of eight patients with typical myasthenia gravis and in five controls, by means of (125)1-labeled alpha-bungarotoxin binding. The junctional acetylcholine receptors were reduced in the myasthenic muscles as compared with the controls. This reduction in receptors may account for the defect in neuromuscular transmission in myasthenia gravis.
Sequence Specific Hybridization Properties of Methylphosphonate Oligodeoxynucleotides (1999)

Methylphosphonate oligodeoxynucleotides (MPO's) with isomerically pure Rp-configurated methylphosphonates (MP's) were synthesized by block coupling of ApT and TpA dinucleoside methylphosphonates (DMP's, p indicating MP-linkage). Oligonucleotide duplexes (20 mers) with these Rp-MP's showed almost the same melting temperatures (Tm) as those with phosphorodiester bonds. Further a dependence of the duplex stability from the nucleosides (bases) adjacent to the MP moiety was observed. For the first time thermodynamic parameters for the duplex to coil transition of isomerically pure MP's were determined from the concentration dependence of the Tm. CD-spectra of the duplexes show structural changes which can be associated with the transition to a compact helix with higher helix winding angle.
A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgia. (2008)

Pregabalin at 300, 450, and 600 mg/day was efficacious and safe for treatment of pain associated with FM. Pregabalin monotherapy provides clinically meaningful benefit to patients with FM.
Generating Abstract Explanations of Spurious Counterexamples in C Programs (2002)

Counterexample driven refinement is a promising technique to generate automatic abstractions for model checking software. A central problem in automating this approach is the refinement of models from spurious error traces. We present a solution to this problem for C programs. Our solution introduces compile time names for run time values, and handles all constructs in the C programming language. We present Newton, an implementation of our solution, and empirical results from running Newton on several C programs.
Total Synthesis of (−)‐Epothilone A (1997)

High diastereoselectivity is observed for the aldol reaction of the optically active building blocks 1 and 2. Another key step in the total synthesis of epothilone A is a ring-closing metathesis. This highly convergent strategy offers many alternatives for the synthesis of biologically active analogs.
A Barium-Titanate-Ceramics Capacitive-Type EEG Electrode (1973)

A capacitive-type electrode using barium titanate ceramics is described. This electrode is not affected by the polarization potential. Because its surface is chemically inactive and mechanically strong, its noise voltage is minimum from the beginning of its installation. This device is especially suitable for EEG recording.
New insights into reservoir filling and mixing processes (2004)

Abstract A common assumption is that hydrocarbon charge homogenizes with the petroleum already in a trap: thus, compositional gradients reflect only subsequent segregation of the petroleum under the combined influences of gravity, temperature and diffusion. Since such homogenization would entail an unfavourable generation of potential energy, a more plausible hypothesis is that hydrocarbons stack into traps roughly in the density sequences in which they arrive. The commonly accepted model suggests that homogeneous and gravitationally unstable petroleum columns move towards graded equilibrium ones, whereas the hypothesis preferred here implies that they gradually diffuse towards equilibrium from the opposite direction, i.e. poorly mixed initial states. According to this hypothesis, trends of oil GOR and bubble point ( P b ) are controlled by either (a) the charge GOR or (b) the evolving PT conditions at the GOC, depending on the gassiness of the charge. By contrast, API gravity trends mainly reflect the integrated maturity histories of source rock kitchens during the trap filling regardless of the charge gassiness. Because trap and kitchen histories are usually (very) different, a wide spectrum of API and GOR (and P b ) combinations is possible, from minor API gradients coupled with large GOR gradients and vice versa .
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks (2018)

EudraCT Identifier: 2015-003943-20; ClinicalTrials.gov Identifier: NCT02586805.
A plasmid-based reverse genetics system for influenza A virus (1996)

A reverse genetics system for negative-strand RNA viruses was first successfully developed for influenza viruses. This technology involved the transfection of in vitro-reconstituted ribonucleoprotein (RNP) complexes into influenza virus-infected cells. We have now developed a method that allows intracellular reconstitution of RNP complexes from plasmid-based expression vectors. Expression of a viral RNA-like transcript is achieved from a plasmid containing a truncated human polymerase I (polI) promoter and a ribozyme sequence that generates the desired 3' end by autocatalytic cleavage. The polI-driven plasmid is cotransfected into human 293 cells with polII-responsive plasmids that express the viral PB1, PB2, PA, and NP proteins. This exclusively plasmid-driven system results in the efficient transcription and replication of the viral RNA-like reporter and allows the study of cis- and trans-acting signals involved in the transcription and replication of influenza virus RNAs. Using this system, we have also been able to rescue a synthetic neuraminidase gene into a recombinant influenza virus. This method represents a convenient alternative to the previously established RNP transfection system.
Progressive left ventricular remodeling and apoptosis late after myocardial infarction in mouse heart (2000)

We tested the hypothesis that left ventricular (LV) remodeling late after myocardial infarction (MI) is associated with myocyte apoptosis in myocardium remote from the infarcted area and is related temporally to LV dilation and contractile dysfunction. One, four, and six months after MI caused by coronary artery ligation, LV volume and contractile function were determined using an isovolumic balloon-in-LV Langendorff technique. Apoptosis and nuclear morphology were determined by terminal deoxynucleotidyl transferase-mediated nick end-labeling (TUNEL) and Hoechst 33258 staining. Progressive LV dilation 1-6 mo post-MI was associated with reduced peak LV developed pressure (LVDP). In myocardium remote from the infarct, there was increased wall thickness and expression of atrial natriuretic peptide mRNA consistent with reactive hypertrophy. There was a progressive increase in the number of TUNEL-positive myocytes from 1 to 6 mo post-MI (2.9-fold increase at 6 mo; P < 0. 001 vs. sham). Thus LV remodeling late post-MI is associated with increased apoptosis in myocardium remote from the area of ischemic injury. The frequency of apoptosis is related to the severity of LV dysfunction.
Polyamine Analogues of 3β-[N-(N′,N′-Dimethylaminoethane)carbamoyl]cholesterol (DC-Chol) as Agents for Gene Delivery (1998)

Gene delivery with cationic liposomes formed from the diamine-lipid DC-Chol and the neutral lipid DOPE has proven successful. New polyamine analogues of DC-Chol have been synthesised, formulated into cationic liposomes with DOPE and biologically tested in vitro and in vivo in mouse lung. Cationic liposomes containing the novel DC-Chol analogue CTAP (shown below) work 100 times more effectively in vivo than DC-Chol containing liposomes (500 times better than DNA alone) and therefore should be suitable for use in human gene therapy approaches towards lung disorders and other clinical conditions.
Oral Aloe vera as a treatment for osteoarthritis: a summary (2010)

While pain relief is a basic tenet of health care, pain is under-treated in the UK (Davies and Mcvicar, 2000) and this issue remains unresolved. This paper suggests that oral Aloe vera could be used in the treatment of chronic non-cancer pain (CNCP), particularly that caused by osteoarthritis (OA). Despite being used as arthritis treatment for centuries (Yoo et al, 2008), evidence of effectiveness of Aloe vera is anecdotal or from small studies. The perceived benefits of prescribing Aloe vera for OA may be twofold: it has utility as an anti-inflammatory agent and also as a prophylactic against the gastrointestinal irritant effects of non-steroidal anti-inflammatory drugs (NSAIDs). Long-term, randomized, controlled studies are still needed to address the lack of evidence informing optimum prescribing of pain medication for people with OA (Cowan, 2007). There is no reason that so called 'nutraceutical' agents should not be subjected to the same rigorous randomized, controlled, double-blind trials as other 'mainstream' drugs. Therefore, it is appropriate to ask whether NSAID treatment and side effects can be improved by the addition of oral Aloe vera. Thus, we may then be in a more informed position to resolve the ongoing 'Pandemonium over Painkillers' (Cowan, 2007).
The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone (FCM) significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group (2004)

In follicular lymphoma (FL) and mantle cell lymphoma (MCL) the monoclonal antibody rituximab may improve the prognosis when combined with chemotherapy. This was investigated in a prospective randomized study in patients with relapsed disease. A total of 147 patients were randomized to receive 4 courses of chemotherapy with 25 mg/m(2) fludarabine on days 1 to 3, 200 mg/m(2) cyclophosphamide on days 1 to 3, and 8 mg/m(2) mitoxantrone on day 1 (FCM), alone or combined with rituximab (375 mg/m(2); R-FCM). Of 128 evaluable patients, 62 were randomized for FCM and 66 for R-FCM. R-FCM revealed an overall response rate of 79% (33% complete remission [CR], 45% partial remission [PR]) as compared with 58% for FCM alone (13% CR, 45% PR; P = .01), with similar results in a subgroup analysis of FL (94% vs 70%) and MCL (58% vs 46%). In the total group, the R-FCM arm was significantly superior concerning progression-free survival (PFS; P = .0381) and overall survival (OS; P = .0030). In FL PFS was significantly longer in the R-FCM arm (P = .0139) whereas in MCL a significantly longer OS was observed (P = .0042). There were no differences in clinically relevant side effects in both study arms. Hence, the addition of rituximab to FCM chemotherapy significantly improves the outcome of relapsed or refractory FL and MCL.
The Matrix Metalloproteinase-14 (MMP-14) Gene Is Structurally Distinct from Other MMP Genes and Is Co-expressed with the TIMP-2 Gene during Mouse Embryogenesis (1997)

The matrix metalloproteinases (MMPs) are a family of zinc-containing matrix degrading endopeptidases. A subfamily of membrane type (MT) -MMPs has been described recently. We have determined the structure of the gene (Mmp14) encoding the first MT-MMP to be described, MT1-MMP (MMP-14), and mapped it to mouse chromosome 14. The mouse MMP-14 protein is encoded by ten exons. The novel C-terminal peptide domains of MMP-14 are encoded by a single large exon that also encodes the 3'-untranslated region. The structure of the exons encoding the catalytic domain and pro-domain of MMP-14 is distinct from previously described MMP genes, whereas the exons encoding the hemopexin-like domains are similar to those of most other MMP genes. Mmp14 and the gene for tissue inhibitor of metalloproteinases-2 (Timp2) show a temporally and spatially co-regulated expression during mouse development. They are co-expressed during vascular and urogenital development and during the development of osteocartilaginous and musculotendinous structures. The stringent co-expression of these two genes suggests common regulatory pathways that may have important functional implications for the activation of pro-gelatinase A in health and disease.
Vertebrate genome evolution: a slow shuffle or a big bang? (1999)

In vertebrates it is often found that if one considers a group of genes clustered on a certain chromosome, then the homologues of those genes often form another cluster on a different chromosome. There are four explanations, not necessarily mutually exclusive, to explain how such homologous clusters appeared. Homologous clusters are expected at a low probability even if genes are distributed at random. The duplication of a subset of the genome might create homologous clusters, as would a duplication of the entire genome. Alternatively, it may be adaptive for certain combinations of genes to cluster, although clearly the genes must have duplicated prior to rearrangement into clusters. Molecular phylogenetics provides a means to examine the origins of homologous clusters, although it is difficult to discriminate between the different explanations using current data. However, with more extensive sequencing and mapping of vertebrate genomes, especially those of the early diverging chordates, it should soon become possible to resolve the origins of homologous clusters.
Biocompatible and detectable carboxylated nanodiamond on human cell (2007)

Surface-modified carboxylated nanometre-sized diamond (cND) has been applied for the conjugation of biological molecules such as DNA and protein. In this study, we evaluated the biocompatibility and detection of cNDs and carbon nanotubes on human lung A549 epithelial cells and HFL-1 normal fibroblasts. Treatment with 5 or 100 nm cND particles, 0.1–100 µg ml−1, did not reduce the cell viability and alter the protein expression profile in lung cells; however, carbon nanotubes induced cytotoxicity in these cells. The cNDs particles were accumulated in A549 cells, which were observed by atomic force microscopy and laser scanning confocal microscopy. Both 5 and 100 nm cNDs particles exhibited the green fluorescence and were ingested into cells. Moreover, the fluorescence intensities were increased in cells via a concentration-dependent manner after treatment with 5 and 100 nm cNDs, which can be detected by flow cytometer analysis. The fluorescence intensities of 5 nm cNDs were relative higher than 100 nm cNDs in cells at equal concentration treatment. The observation demonstrated that cND-interacting with cell is detectable by a confocal microscope, flow cytometer and atomic force microscope. These nanoparticles may be useful for further biomedical applications based on the properties of uptake ability, detectability and little cytotoxicity in human cells.
13C breath test in gastroenterological practice. (1998)

Breath tests (BTs) are used in gastroenterological practice to study (patho)physiological and metabolic processes in an indirect way. In these tests the appearance in breath of a metabolite of a specific test substance is studied. The assumption underlying each BT is that one step-the process of interest-in the absorption and metabolism of the tracer is rate-limiting. Both hydrogen gas excretion and carbon dioxide appearance in breath can be studied. When a carbon-labelled test substance is used. the stable isotope 13C is preferred to the radioactive isotope 14C. Measurements of 13C in expired air are performed by mass spectrometry. Because of the indirect nature of BTs, involving a sequence of reactions and metabolic pools, they usually supply semiquantitative data. The tests are nevertheless useful because they often replace invasive techniques with a simple procedure that is safe because there is no radioactivity involved. BTs have been used to measure gastric emptying, the presence of Helicobacter pylori in the stomach, small-bowel bacterial overgrowth, exocrine pancreatic function as well as liver metabolic capacity; other potential applications of BTs are being studied.
A Humanized Form of a CD4-Specific Monoclonal Antibody Exhibits Decreased Antigenicity and Prolonged Plasma Half-Life in Rhesus Monkeys While Retaining Its Unique Biological and Antiviral Properties (1997)

Certain monoclonal antibodies (MAbs) directed against CD4 can efficiently block HIV-1 replication in vitro. To explore CD4-directed passive immunotherapy for prevention or treatment of AIDS virus infection, we previously examined the biological activity of a nondepleting CD4-specific murine MAb, mu5A8. This MAb, specific for domain 2 of CD4, blocks HIV-1 replication at a post-gp120-CD4 binding step. When administered to normal rhesus monkeys, all CD4+ target cells were coated with antibody, yet no cell clearance or measurable immunosuppression occurred. However, strong anti-mouse Ig responses rapidly developed in all monkeys. In the present study, we report a successfully humanized form of mu5A8 (hu5A8) that retains binding to both human and monkey CD4 and anti-AIDS virus activity. When administered intravenously to normal rhesus monkeys, hu5A8 bound to all target CD4+ cells without depletion and showed a significantly longer plasma half-life than mu5A8. Nevertheless, an anti-hu5A8 response directed predominantly against V region determinants did eventually appear within 2 to 4 weeks in most animals. However, when hu5A8 was administered to rhesus monkeys chronically infected with the simian immunodeficiency virus of macaques, anti-hu5A8 antibodies were not detected. Repeated administration of hu5A8 in these animals resulted in sustained plasma levels and CD4+ cell coating with humanized antibody for 6 weeks. These studies demonstrate the feasibility of chronic administration of CD4-specific MAb as a potential means of treating or preventing HIV-1 infection.