gebhart/patrepeval huggingface dataset:
Irinotecan(Campto R): efficacy as third/forth line therapy in advanced pancreatic cancer. (2001)

Following the concept that the actual survival of pancreatic cancer patients can only be significantly improved by sequential poly-chemotherapy (EOSPC) in order to add one or two further progression free-survival times (PFST), in addition to the potential antitumoral effects of a first- or second-line therapy we studied the therapeutic efficacy of a third- or fourth-line chemotherapy with irinotecan alone, or in combination with oxaliplatin and high dose 5-FU/FA respectively, in a pilot study in 17 patients. Follow-up was performed on the basis of clinical investigations, imaging methods and the course of tumor markers, mainly CT and CA 19-9. The overall response rate in these cases of third/fourth-line therapies was 1 PR, 4 MR, 6 SD in the imaging methods compared to 5 PR, 2 MR and 5 SD on the basis of the tumor marker courses in the serum. The median PFST amounted to 4 months. Side effects could be seen as reported in the literature. Only in 1 patient did treatment have to be stopped due to irinotecan-induced gastrointestinal symptoms. Our data might suggest that combinations are more effective than irinotecan alone. However, further studies have to demonstrate whether irinotecan alone or in combination with e.g. oxaliplatin and 5-FU/FA will be more effective. The results suggested that irinotecan alone or in combination might also be used as third- and fourth-line therapeutical trials in exocrine pancreatic cancer in order to improve the survival time of these patients based on efficacy orientated sequential poly-chemotherapy (EOSPC).
Anti-CD45 Mediated Cytolysis of Human T-Cell Lymphoma Cells. (2004)

Abstract Anti-CD45 mediated cytoreduction is an effective means for T-cell depletion in rodents and humans. In man, the CD45-specific rat monoclonal antibodies YTH24 and YTH54 are IgG2b subclass, exert a predominantly complement-dependent cytolytic activity against normal T-lymphocytes, and have been safely given to patients as part of conditioning therapies for allogeneic stem cell transplantation. The efficacy of such antibodies against human lymphoma is unknown. Therefore, we evaluated the cytolytic activity of YTH24 and YTH54 by complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC), as well as by direct apoptotic and antiproliferative effects, against a panel of Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) cell lines, and against primary specimens. Significant CDC activity (&amp;gt;50% cytolysis) of the antibodies YTH54 and YTH24 was observed against three of five T-cell lymphoma lines, but against only one of nine B-cell lymphoma lines and none of four HD cell lines. The combination of YTH54 and YTH24 induced ADCC in all T-cell lymphoma cell lines and three primary leukemic T-cell lymphoma specimens, but were ineffective in B-cell lymphoma and HD cell lines.There were only minor effects of either antibody or the combination on lymphoma cell apoptosis or cell cycle arrest. In summary, anti-CD45 mediated CDC and ADCC via the antibodies YTH24 and YTH54 are primarily effective against lymphoma cells with T-cell phenotype, and may be an immunotherapeutic tool for the treatment of human T-cell lymphoma.
The Isomeric 3-Oxa- and 3-Thiagranatanin-7-ols and Their Derivatives; Reduction of Bicyclic Amino Ketones Related to Tropinone1,2 (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Isomeric 3-Oxa- and 3-Thiagranatanin-7-ols and Their Derivatives; Reduction of Bicyclic Amino Ketones Related to Tropinone1,2CHARLES L. ZIRKLE, FRED R. GERNS, ALEX M. PAVLOFF, and ALFRED BURGERCite this: J. Org. Chem. 1961, 26, 2, 395–407Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://doi.org/10.1021/jo01061a032RIGHTS & PERMISSIONSArticle Views346Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Movement of Albumin and Dextran Through the Sclera (1965)

<h3>Introduction</h3> A previous paper<sup>3</sup>reported that labeled albumin injected into the suprachoroid penetrates the sclera through the perivascular spaces and most probably also through other pathways and moves into the conjunctiva where it is then collected by conjunctival lymph vessels. In the present experiments the drainage of albumin from the suprachoroid was studied with an improved technique in animals with an intact anterior chamber and in animals with a low intraocular pressure due to chamber puncture. It was also determined to what extent albumin injected into the suprachoroid can pass into the blood after the cervical lymph vessels have been opened. The routes for colloid drainage through the sclera were studied using red dextran. <h3>Methods</h3> Albino rabbits weighing 1.8 to 2.8 kg were used. Anesthesia was induced by I.V. administration of pentobarbital (30 mg/kg body weight). Additional doses were given if required for the suprachoroidal injection but after this
Oral vaccination of mice against tetanus by use of a live attenuated Salmonella carrier (1990)

A Salmonella typhimurium aroA mutant has been used as a live carrier to immunize mice against tetanus. Plasmid pTETtac4, which expresses a 50-kilodalton fragment of tetanus toxin (fragment C) under the control of the tac promoter, was introduced into SL3261 aroA. When used as a live vaccine and administered orally or intravenously, this strain was able to induce protective immunity in mice against a lethal tetanus toxin challenge. When plasmid pTETtac2, which contains the lacI gene, was used, no immunity was obtained, indicating that the expression of fragment C was repressed in vivo. We believe that this is the first example of a successful oral vaccination that uses an attenuated bacterial carrier to deliver a protective antigen derived from tetanus toxin.
Power management of online data-intensive services (2011)

Much of the success of the Internet services model can be attributed to the popularity of a class of workloads that we call Online Data-Intensive (OLDI) services. These workloads perform significant computing over massive data sets per user request but, unlike their offline counterparts (such as MapReduce computations), they require responsiveness in the sub-second time scale at high request rates. Large search products, online advertising, and machine translation are examples of workloads in this class. Although the load in OLDI services can vary widely during the day, their energy consumption sees little variance due to the lack of energy proportionality of the underlying machinery. The scale and latency sensitivity of OLDI workloads also make them a challenging target for power management techniques.
SYNTHÈSES D'ACIDES AMINOBUTYRIQUES: II. ACIDES ALKYLAMINO-2 HYDROXY-4 BUTYRIQUES (1962)

Starting from 2-bromo-4-butyrolactone which was treated with primary amines, five new 2-alkylamino-4-hydroxy-N-alkylbutyramides were obtained in good yields. Acid hydrolysis gave the corresponding lactones, which, when treated with Ba(OH) 2 , gave the 2-alkylamino-4-hydroxybutyric acids. The new derivatives of homoserine thus prepared are: 2-methylamino-4-hydroxybutyric acid, 2-ethylamino-4-hydroxybutyric acid, 2-propylamino-4-hydroxybutyric acid, 2-butylamino-4-hydroxybutyric acid, and 2-cyclohexylamino-4-hydroxybutyric acid.Some of these amides were easily lactonized in HCl-acetone medium. Two 2-alkylamino-4-chloro-N-alkylbutyramides were also prepared.
Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion. (1987)

Interactions between retroviruses associated with acquired immunodeficiency syndrome and their receptors on lymphocytes represent the initial steps in the process of infection and are also involved in multinucleated giant cell formation, which is one form of virus-mediated cytopathology. The exterior envelope glycoprotein of the retrovirus has been identified as gp120, and we demonstrate here that purified gp120 binds directly to cells expressing the CD4 (T4) surface antigen at a site spatially related to that recognized by the OKT4A monoclonal antibody. The gp120 was also able to temporarily interfere with viral infection and to block the process of multinucleated giant cell formation. However, if the carbohydrate chains were removed from gp120 by enzymatic treatment, CD4 binding and blockade of cell fusion was reduced by about a factor of 50. The significance of these results in relation to preventive and interventive approaches for acquired immunodeficiency syndrome is discussed.
Low-Profile, Multi-Element, Miniaturized Monopole Antenna (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> A low-profile, electrically small antenna with omnidirectional vertically polarized radiation similar to a short monopole antenna is presented. The antenna features less than <formula formulatype="inline"><tex Notation="TeX">$\lambda/40$</tex> </formula> dimension in height and <formula formulatype="inline"><tex Notation="TeX">$\lambda/10$</tex> </formula> or smaller in lateral dimension. The antenna is matched to a 50 <formula formulatype="inline"><tex Notation="TeX">$\Omega$</tex></formula> coaxial line without the need for external matching. The geometry of the antenna is derived from a quarter-wave transmission line resonator fed at an appropriate location to maximize current through the short-circuited end. To improve radiation from the vertical short-circuited pin, the geometry is further modified through superposition of additional resonators placed in a parallel arrangement. The lateral dimension of the antenna is miniaturized by meandering and turning the microstrip lines into form of a multi-arm spiral. The meandering between the short-circuited end and the feed point also facilitates the impedance matching. Through this technique, spurious horizontally polarized radiation is also minimized and a radiation pattern similar to a short dipole is achieved. The antenna is designed, fabricated and measured. Parametric studies are performed to explore further size reduction and performance improvements. Based on the studies, a dual-band antenna with enhanced gain is realized. The measurements verify that the proposed fabricated antennas feature excellent impedance match, omnidirectional radiation in the horizontal plane and low levels of cross-polarization. </para>
Toward an in vitro system for picornavirus assembly: purification of mengovirus 14S capsid precursor particles (1986)

Mengovirus 14S subviral protein particles generated in infected L cells and in a cell-free translation system primed with mengovirus RNA were purified by sucrose gradient centrifugation and immunoaffinity chromatography. The preparations from both sources contained essentially pure proteins epsilon, alpha, and gamma, as was demonstrated in terms of virus-specific proteins (by autoradiography) and total protein content (by silver staining of sodium dodecyl sulfate-polyacrylamide electrophoresis gels). These purified proteins sedimented as discrete particles at the 14S position when recentrifuged in sucrose gradients. Although their assembly properties have not yet been studied in detail, preliminary results indicate that during incubation with virion RNA the 14S particles purified from infected cells can form a structure cosedimenting with mature mengovirus.
Selective Solubilization of Glycoproteins of Milk Fat Globule Membrane with KCl and MgCl2 (1980)

Journal Article Selective Solubilization of Glycoproteins of Milk Fat Globule Membrane with KCl and MgCl2 Get access Choemon Kanno, Choemon Kanno Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Present address: Department of Animal Science, Utsunomiya University, Utsunomiya 320, Japan. Search for other works by this author on: Oxford Academic Google Scholar Shuji Nakamura, Shuji Nakamura Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Kunio Yamauchi Kunio Yamauchi Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 44, Issue 5, 1 May 1980, Pages 1193–1194, https://doi.org/10.1080/00021369.1980.10864101 Published: 01 May 1980 Article history Received: 28 November 1979 Published: 01 May 1980
Pooled analysis of the safety and tolerability of onabotulinumtoxinA in the treatment of chronic migraine (2014)

Multiple treatments with onabotulinumtoxinA at doses of 75-260 U administered every 12 weeks, and up to five treatment cycles, were well tolerated for the prophylaxis of headache in adults with CM.
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors (2007)

Targeted cancer therapies impede cancer cell growth by inhibiting the function of activated oncogene products. Patients with non-small cell lung cancer and somatic mutations of EGFR can have a dramatic response to treatment with erlotinib and gefitinib; different somatic mutations are associated with different times to progression and survival. In this study, the relative and absolute potencies of two distinct EGFR tyrosine kinase inhibitors, erlotinib and an investigational irreversible inhibitor, HKI-272, were found to vary significantly in a panel of Ba/F3 cells transformed by representative EGFR somatic mutations. HKI-272 more potently inhibited the primary exon 20 insertion mutants, the secondary erlotinib-resistance mutants including T790M and many erlotinib-sensitive mutants including L858R. In contrast, erlotinib is a more potent inhibitor of the major exon 19 deletion mutants than is HKI-272. Analyses of EGFR autophosphorylation patterns confirmed the mutation-specific variation in relative potency of these tyrosine kinase inhibitors. Our finding that distinct EGFR inhibitors are more effective in vitro for different mutant forms of the protein suggests that tyrosine kinase inhibitor treatment could be tailored to specific EGFR mutations. More broadly, these results imply that the development and deployment of targeted therapies should focus on inhibition of specific cancer-causing mutations, not only on the mutated target.
Automated Client-side Integration of Distributed Application Servers (1999)

Permission is granted for noncommercial reproduction of the work for educational or research purposes.
OptiSim:  An Extended Dissimilarity Selection Method for Finding Diverse Representative Subsets (1997)

Compound selection methods currently available to chemists are based on maximum or minimum dissimilarity selection or on hierarchical clustering. Optimizable K-Dissimilarity Selection (OptiSim) is a novel and efficient stochastic selection algorithm which includes maximum and minimum dissimilarity-based selection as special cases. By adjusting the subsample size parameter K, it is possible to adjust the balance between representativeness and diversity in the compounds selected. The OptiSim algorithm is described, along with some analytical tools for comparing it to other selection methods. Such comparisons indicate that OptiSim can mimic the representativeness of selections based on hierarchical clustering and, at least in some cases, improve upon them.
Fourier spectra of digital halftone images containing dot-position errors (1988)

Random laser-writer position errors in raster-scanned monochrome halftone images are examined by using Fourier analysis techniques. For a high-contrast, narrow-exposure latitude recording material (typically used in halftone reproduction) with medium-sized halftone dots (25–85%), a one-dimensional halftone model is developed to derive the signal power spectrum of a halftone image containing position errors in the slow-scan (page-scan) direction. The spectrum of such an image is shown to consist of a periodic component and a random component, which is a function of position error but independent of dot size. The term signal power spectrum, in the context of this paper, is the average squared modulus of the Fourier transform of an image containing these errors. A comparison is made between the percent position-error specification quoted for continuous-tone laser writing and the corresponding specification made in writing digital halftones. For a given absolute position error, the ratio of the resulting percent position error of a single pixel in continuous-tone writing to that for a halftone cell is shown to be roughly 2(X/L), where X is the halftone cell period and L is the pixel size used in continuous-tone reconstruction. Thus, whereas the position-error tolerance for halftone writing is almost an order of magnitude greater than its continuous-tone counterpart on a percent basis, on an absolute scale they are approximately equal. The results can be generalized to include any digitally generated halftone image based on a center-growing dot configuration and containing dot-size/shape distortions.
Human alpha-L-iduronidase. 1. Purification, monoclonal antibody production, native and subunit molecular mass (1985)

Human alpha-L-iduronidase from liver was purified about 20 000-fold with a new rapid three-step, five-column procedure which consisted of a Concanavalin-A-Sepharose/Blue-A-Agarose coupled step, a CM-Sepharose/Bio-Gel HT coupled step followed by a cupric-ion-chelating Sepharose 6B step. The behaviour of alpha-L-iduronidase on gel permeation chromatography was dependent upon both pH and ionic strength of the eluting buffer. The formation of species with enzyme activity which behaved as large-molecular-mass aggregates was favoured under conditions of low ionic strength and neutral pH. The amount of high-Mr species diminished as the pH decreased or the ionic strength increased to favour a single active species of Mr 65 000. A specific monoclonal antibody was generated against liver alpha-L-iduronidase. The antibody specifically immunoprecipitated enzyme activity from both crude and purified sources. The subunit Mr of liver alpha-L-iduronidase was estimated to be 65 000 using SDS-PAGE. Monoclonal antibody immunoprecipitation of radiolabelled enzyme was used to provide definitive confirmation of this subunit size.
A Kalman Filter-Based Algorithm for IMU-Camera Calibration: Observability Analysis and Performance Evaluation (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Vision-aided inertial navigation systems (V-INSs) canprovide precise state estimates for the 3-D motion of a vehicle when no external references (e.g., GPS) are available. This is achieved bycombining inertial measurements from an inertial measurement unit (IMU) with visual observations from a camera under the assumption that the rigid transformation between the two sensors is known. Errors in the IMU-camera extrinsic calibration process cause biases that reduce the estimation accuracy and can even lead to divergence of any estimator processing the measurements from both sensors. In this paper, we present an extended Kalman filter for precisely determining the unknown transformation between a camera and an IMU. Contrary to previous approaches, we explicitly account for the time correlation of the IMU measurements and provide a figure of merit (covariance) for the estimated transformation. The proposed method does not require any special hardware (such as spin table or 3-D laser scanner) except a calibration target. Furthermore, we employ the observability rank criterion based on Lie derivatives and prove that the nonlinear system describing the IMU-camera calibration process is observable. Simulation and experimental results are presented that validate the proposed method and quantify its accuracy. </para>
Separation of Soil Clods from Onions Using Impact (1984)

A unit was developed that separates onions from soil clods by the difference in their rebound trajectories, after bouncing on a rotating steel roller. The effect of the parameters was investigated in the laboratory with two modes of operation, forward and backward bouncing. Feeding velocity and impingement location on the roller were found to be very critical factors. At the proper combination of the parameters, good separation was obtained. A field unit based on two stages was operated successfully on an onion harvester
Theory of reproducing kernels (1950)

May 7. Difference of reproducing kernels.354 8. Product of reproducing kernels.357 9. Limits of reproducing kernels.362 10.Construction of a r.k. by resolution of identity.368 11.Operators in spaces with reproducing kernels.371 12.The reproducing kernel of a sum of two closed subspaces.375 13.Final remarks in the general theory.380 Part II.Examples.384 1.I ntroductory remarks.384 (1) Bergman's kernels.384 (2) Harmonic kernels.386 2. Comparison domains.387 3. The difference of kernels.388 4. The square of a kernel introduced by Szeg.391 5.The kernel H{z, zi) for an ellipse.393 6. Construction of H(z, z) for a strip.394 7. Limits of increasing sequences of kernels.396 8. Construction of reproducing kernels by the projection-formula of 12, I.
Global expression analysis of gene regulatory pathways during endocrine pancreatic development (2003)

To define genetic pathways that regulate development of the endocrine pancreas, we generated transcriptional profiles of enriched cells isolated from four biologically significant stages of endocrine pancreas development: endoderm before pancreas specification, early pancreatic progenitor cells, endocrine progenitor cells and adult islets of Langerhans. These analyses implicate new signaling pathways in endocrine pancreas development, and identified sets of known and novel genes that are temporally regulated, as well as genes that spatially define developing endocrine cells from their neighbors. The differential expression of several genes from each time point was verified by RT-PCR and in situ hybridization. Moreover, we present preliminary functional evidence suggesting that one transcription factor encoding gene (Myt1), which was identified in our screen, is expressed in endocrine progenitors and may regulate alpha, beta and delta cell development. In addition to identifying new genes that regulate endocrine cell fate, this global gene expression analysis has uncovered informative biological trends that occur during endocrine differentiation.