gebhart/patrepeval huggingface dataset:
The glpT and glpQ genes of the glycerol regulon in Bacillus subtilis (1994)

The cloning of the Bacillus subtilis glpT and glpQ genes and their nucleotide sequences are reported. Analysis of mRNA indicates that glpT and glpQ constitute one operon which is transcribed from a sigma A type promoter. The steady state amount of glpTQ mRNA is increased in cells grown in the presence of glycerol 3-phosphate. The 5' untranslated leader sequence of glpTQ mRNA contains an inverted repeat which shows sequence similarity to repeats present in the leader sequences of glpFK and glpD transcripts. These repeats seem therefore to be essential control elements for all B. subtilis glp genes.
The Reaction of the Urinary Tract to Catgut and Reconstituted Collagen Sutures (1969)

No AccessJournal of Urology1 Mar 1969The Reaction of the Urinary Tract to Catgut and Reconstituted Collagen Sutures Francis F. Bartone and Thomas K. Shires Francis F. BartoneFrancis F. Bartone Current address: University of Nebraska College of Medicine, 42nd and Dewey Streets, Omaha, Nebraska 68105 More articles by this author and Thomas K. ShiresThomas K. Shires More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62357-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1969 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byStewart D, Buffington P and Wacksman J (2018) Suture Material in Bladder Surgery a Comparison of Polydioxanone, Polyglactin, and Chromic CatgutJournal of Urology, VOL. 143, NO. 6, (1261-1263), Online publication date: 1-Jun-1990.Bartone F and Adickes E (2018) Chitosan: Effects on Wound Healing in Urogenital Tissue: Preliminary ReportJournal of Urology, VOL. 140, NO. 5 Part 2, (1134-1137), Online publication date: 1-Nov-1988.Edlich R, Rodeheaver G and Thacker J (2018) Considerations in the Choice of Sutures for Wound Closure of the Genitourinary TractJournal of Urology, VOL. 137, NO. 3, (373-379), Online publication date: 1-Mar-1987. Volume 101Issue 3March 1969Page: 411-416 Advertisement Copyright & Permissions© 1969 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Francis F. Bartone Current address: University of Nebraska College of Medicine, 42nd and Dewey Streets, Omaha, Nebraska 68105 More articles by this author Thomas K. Shires More articles by this author Expand All Advertisement PDF downloadLoading ...
Present Status of the Use of Cytokines as Adjuvants with Vaccines to Protect Against Infectious Diseases (1995)

Vaccine adjuvants are expected to play an important role in enhancing the immunogenicity of existing and new-generation vaccines against infectious diseases. In particular, adjuvants should direct the immune response in the most appropriate manner--furthering, for example, an expanded B-cell response, a cytotoxic T-cell response, or a T-helper 1 or 2 subset response. While some noncytokine adjuvants have exerted potent effects, their modes of action are most likely mediated by cytokines. Several cytokines have already been shown to be efficient adjuvants in animal models and/or in clinical trials. The mechanisms of cytokine function must be better understood and the techniques for the use of cytokines improved if the full potential of these substances as vaccine adjuvants is to be realized. When used to best advantage, such adjuvants enhance the immunity induced by viral, bacterial, and parasitic vaccines and thereby promote efficient protection or even cure.
Population pharmacokinetic analysis of ulotaront in subjects with schizophrenia (2021)

Ulotaront (SEP-363856) is a trace amine-associated receptor 1 agonist with 5-HT<sub>1A</sub> agonist activity in phase III development for the treatment of schizophrenia. The efficacy of ulotaront is not mediated by blockade of D<sub>2</sub> or 5-HT<sub>2A</sub> receptors. The aim of this study was to evaluate the population pharmacokinetics (PopPKs) of ulotaront in adult subjects using pooled data from seven phase I studies, one phase II acute study, and one 6-month extension study. Single and multiple (up to 7 days) oral doses (5-150 mg/day) were studied in both healthy adult subjects (with intensive serial plasma sampling) and adult patients with schizophrenia (some with intensive and some with sparse plasma sampling). Ulotaront was well-absorbed and exhibited dose-proportionality in doses ranging from 10 to 100 mg, in mean maximum concentration, area under the concentration-time curve, and minimum concentration. Moderate interindividual variability was observed in concentration-time profiles. The estimated median time to maximal concentration was 2.8 h and the median effective half-life was 7 h, corresponding to an exposure accumulation ratio of 1.10 at steady-state with daily dosing. There was no indication of time-dependent changes in PKs after up to 12 weeks of daily dose administration. No clinically meaningful effects on ulotaront PK parameters were observed based on race, age, sex, formulation (capsule or tablet), or clinical status (healthy volunteer vs. patient with schizophrenia); body weight was the only meaningful covariate.
Multi-Oriented Text Lines Detection, Their Skew Estimation. (2002)

There are some documents where text lines are not parallel to each other i.e. different text lines of a single page may have different inclinations (orientations) with the horizontal lines. To enhance the ability of document analysis system, we need text line extraction in multiple orientations. In this papers we propose a robust technique (a) to detect text lines of arbitrary orientation in a single document page, and (b) to detect skew angle of individual text line. We use here a bottom-up approach where the connected components are at first labeled. They are then clustered into word groups. Text lines of arbitrary orientation are segmented from the estimation of these word groups. From an experiment of 3045 text lines we obtained an accuracy of 97.7% by the proposed method.
Learning from Noisy Large-Scale Datasets with Minimal Supervision (2017)

We present an approach to effectively use millions of images with noisy annotations in conjunction with a small subset of cleanly-annotated images to learn powerful image representations. One common approach to combine clean and noisy data is to first pre-train a network using the large noisy dataset and then fine-tune with the clean dataset. We show this approach does not fully leverage the information contained in the clean set. Thus, we demonstrate how to use the clean annotations to reduce the noise in the large dataset before fine-tuning the network using both the clean set and the full set with reduced noise. The approach comprises a multi-task network that jointly learns to clean noisy annotations and to accurately classify images. We evaluate our approach on the recently released Open Images dataset, containing ~9 million images, multiple annotations per image and over 6000 unique classes. For the small clean set of annotations we use a quarter of the validation set with ~40k images. Our results demonstrate that the proposed approach clearly outperforms direct fine-tuning across all major categories of classes in the Open Image dataset. Further, our approach is particularly effective for a large number of classes with wide range of noise in annotations (20-80% false positive annotations).
Reduction of Intermediate Alphabets in Finite-State Transducer Cascades (2000)

This article describes an algorithm for reducing the intermediate alphabets in cascades of finite-state transducers (FSTs). Although the method modifies the component FSTs, there is no change in the overall relation described by the whole cascade. No additional information or special algorithm, that could decelerate the processing of input, is required at runtime. Two examples from Natural Language Processing are used to illustrate the effect of the algorithm on the sizes of the FSTs and their alphabets. With some FSTs the number of arcs and symbols shrank considerably.
Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides. (1992)

Certain of the glycoprotein hormones, including bovine lutropin (bLH), bear asparagine-linked oligosaccharides terminating with the sequence SO4-4GalNAc beta 1-4GlcNAc beta 1-2Man alpha. To establish the biologic significance of these sulfate-bearing oligosaccharides we have compared properties of native bLH, desulfated bLH, recombinant bLH produced in Chinese hamster ovary cells that bears asparagine-linked oligosaccharides terminating with sialic acid alpha 2- 3Gal beta 1-4GlcNAc beta 1-2Man alpha rather than sulfated oligosaccharides (bLH/CHO), and desialyzed bLH/CHO. Using cultured MA-10 cells, a Leydig cell tumor line expressing the lutropin/chorionic gonadotropin receptor, we have found no differences in binding, cAMP production, or progesterone production between native and desulfated bLH. Sulfation of bLH oligosaccharides does not, therefore, modulate bLH bioactivity at the level of the lutropin/chorionic gonadotropin receptor. Removal of sulfate from bLH oligosaccharides and sialic acid from bLH/CHO oligosaccharides results in rapid clearance from the circulation by the hepatocyte asialoglycoprotein receptor. Thus sulfate, like sialic acid, prevents clearance from the circulation by the asialoglycoprotein receptor. The rapid removal of desulfated bLH from the circulation causes a 4- to 16-fold increase in the amount of bLH required to stimulate ovulation compared with native bLH. Particularly striking were differences in the metabolic clearance rates for native bLH and bLH/CHO, 7.3% per min and 1.7% per min, respectively. These differences were unexpected because bLH and bLH/CHO do not differ significantly in charge or size. The different metabolic clearance rates obtained for bLH and bLH/CHO indicate that the presence of sulfated rather than sialylated oligosaccharides on bLH results in a shorter circulatory half-life, which has a significant impact on in vivo bioactivity.
Hydrogen adsorption on boron nitride nanotubes: A path to room-temperature hydrogen storage (2004)

The adsorption of molecular hydrogen on boron nitride nanotubes is studied with the use of the pseudopotential density functional method. The binding energy and distance of adsorbed hydrogen is particularly calculated. It is found that the binding energy of hydrogen on boron nitride nanotubes is increased by as much as $40%$ compared to that on carbon nanotubes, which is attributed to heteropolar bonding in boron nitride. The effect of substitutional doping and structural defects on hydrogen adsorption is also studied and we find a substantial enhancement of the binding energy from that on perfect boron nitride. The current study demonstrates a pathway to the finding of proper media that can hold hydrogen at ambient conditions through physisorption.
Crystal and Magnetic Structures in Layered, Transition Metal Dihalides and Trihalides (2017)

Materials composed of two dimensional layers bonded to one another through weak van der Waals interactions often exhibit strongly anisotropic behaviors and can be cleaved into very thin specimens and sometimes into monolayer crystals. Interest in such materials is driven by the study of low dimensional physics and the design of functional heterostructures. Binary compounds with the compositions M X 2 and M X 3 where M is a metal cation and X is a halogen anion often form such structures. Magnetism can be incorporated by choosing a transition metal with a partially filled d-shell for M, enabling ferroic responses for enhanced functionality. Here a brief overview of binary transition metal dihalides and trihalides is given, summarizing their crystallographic properties and long-range-ordered magnetic structures, focusing on those materials with layered crystal structures and partially filled d-shells required for combining low dimensionality and cleavability with magnetism.
Interactions of Bacteria, Fungi, and their Nematode Grazers: Effects on Nutrient Cycling and Plant Growth (1985)

The most common system responses attributed to microfloral grazers (protozoa, nematodes, microarthropods) in the literature are increased plant growth, increased N uptake by plants, decreased or increased bacterial populations, increased CO 2 evolution, increased N and P mineralization, and increased substrate utilization. Based on this evidence in the literature, a conceptual model was proposed in which microfloral grazers were considered as separate state variables. To help evaluate the model, the effects of microbivorous nematodes on microbial growth, nutrient cycling, plant growth, and nutrient uptake were examined with reference to activities within and outside of the rhizosphere. Blue grama grass (Bouteloua gracilis) was grown in gnotobiotic microcosms containing sandy loam soil low in inorganic N, with or without chitin amendments as a source of organic N. The soil was inoculated with bacteria (Pseudomonas paucimobilis or P. stutzeri) or fungus (Fusarium oxysporum), with half the bacterial microcosms inoculated with bacterial—feeding nematodes (Pelodera sp. or Acrobeloides sp.) and half the fungal microcosms inoculated with fungal—feeding nematodes (Aphelenchus avenae). Similar results were obtained from both the unamended and the chitin—amended experiments. Bacteria, fungi, and both trophic groups of nematodes were more abundant in the rhizosphere than in nonrhizosphere soil. All treatments containing nematodes and bacteria had higher bacterial densities than similar treatments without nematodes. Plants growing in soil with bacteria and bacterial—feeding nematodes grew faster and initially took up more N than plants in soil with only bacteria, because of increased N mineralization by bacteria, NH 4 + —N excretion by nematodes, and greater initial exploitation of soil by plant roots. Addition of fungal—feeding nematodes did not increase plant growth or N uptake because these nematodes excreted less NH 4 + —N than did bacterial—feeding nematode populations and because the N mineralized by the fungus alone was sufficient for plant growth. Total shoot P was significantly greater in treatments with fungus or Pelodera sp. than in the sterile plant control or treatments with plants plus Pseudomonas stutzeri until the end of the experiment. The additional mineralization that occurs due to the activities of microbial grazers may be significant for increasing plant growth only when mineralization by microflora alone is insufficient to meet the plants' requirements. However, while the advantage of increased N mineralization by microbial grazers may be short—term, it may occur in many ecosystems in those short periods of ideal conditions when plant growth can occur. Thus, these results support other claims in the literature that microbial grazers may perform important regulatory functions at critical times in the growth of plants.
The qacG gene on plasmid pST94 confers resistance to quaternary ammonium compounds in staphylococci isolated from the food industry (1999)

The 2.3 kb resistance plasmid pST94 revealed a new gene (qacG) encoding resistance to benzalkonium chloride (BC), a commonly used quaternary ammonium disinfectant, and the intercalating dye ethidium bromide (Eb) in staphylococci isolated from the food industry. The 107 amino acid QacG protein showing 69.2% identity to the staphylococcal multi-drug resistance protein Smr is a new member of the small multi-drug resistance (SMR) protein family. QacG conferred resistance via proton dependent efflux. An additional ORF on pST94 encoded a protein with extensive similarity to replication proteins of other Gram-positive bacteria. Gene constructs containing the qacG and smr gene region combined with the smr or qacG promoter, respectively, indicated that QacG is more efficient than Smr and that qacG has a weaker promoter. Resistant qacG-containing cells could be adapted to withstand higher concentrations of BC. Adapted qacG-containing cells showed increased resistance mainly to BC. In contrast, adaptation of sensitive cells showed cross-resistance development to a range of compounds. Induction of proton-dependent efflux was observed for BC-adapted staphylococci cells not containing qacG. The ability of sublethal concentrations of BC to develop cross-resistance and induce efflux mechanisms could be of practical significance; it should be considered before use of any new disinfectant and in the design of better disinfection procedures.
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. (1999)

Interleukin (IL) 17 is a proinflammatory cytokine secreted mainly by activated human memory CD4 T cells that induces IL-6, IL-8, and nitric oxide. Because IL-6 and IL-8 have been implicated in the pathogenesis of cervical cancer, we investigated the action of IL-17 on human cervical tumor cell lines in vitro and in vivo. We showed that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels. No direct effect of IL-17 on in vitro proliferation of cervical tumor cell lines could be demonstrated. However, two cervical cell lines transfected with a cDNA encoding IL-17 exhibited a significant increase in tumor size as compared to the parent tumor when transplanted in nude mice. This enhanced tumor growth elicited by IL-17 was associated with increased expression of IL-6 and macrophage recruitment at the tumor site. A potential role of IL-17 in modulation of the human cervical tumor phenotype was also supported by its expression on the cervical tumor in patients with CD4 infiltration. IL-17 therefore behaves like a T-cell-specific cytokine with paradoxical tumor-promoting activity. This may partially explain previous reports concerning the deleterious effect of CD4 T cells in cancer.
Integration of block copolymer directed assembly with 193 immersion lithography (2010)

An integration scheme of block copolymer directed assembly with 193 nm immersion lithography is presented. It is experimentally shown that a thin silicon nitride film can be used as an antireflective coating (ARC). With such an ARC, directed assembly of a block copolymer (BCP) to triple the feature density of a chemical pattern was demonstrated. A high quality of assembly was obtained over a large area, and pattern transfer feasibility was illustrated. The integration of feature density multiplication via directed assembly of a BCP with 193 nm immersion lithography provided a pattern quality that was comparable with existing double patterning techniques, suggesting that the process could be a promising candidate for extending the use of current 193 immersion lithography tools to higher pattern densities.
Propulsion systems for electric cars (1974)

Proper selection of the propulsion system to meet the requirements of an electric passenger vehicle is of prime importance. Choice may be made among alternating current, direct current, or combined systems. Each approach can be implemented by utilizing various control techniques and power elements. For instance, an ac system may use an adjustable voltage inverter (AVI) or a pulse-width-modulated inverter (PWMI) for the power processor, and an induction motor or a synchronous motor for the rotating element. Similar alternatives exist for a dc system. The choice of a suitable manner of implementation must be. based on information characterizing the various elements and tradeoffs matching them to the vehicle requirements. This paper describes various ac and dc techniques, characterizes AVI, PWM, and representative dc chopper power processors and examines their interface with a variety of motors such as series, shunt, induction, etc.
Amphiphilic Catalytic Allylating Reagent, Bis-π-allylpalladium Complex (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAmphiphilic Catalytic Allylating Reagent, Bis-π-allylpalladium ComplexHiroyuki Nakamura, Jae-Goo Shim, and Yoshinori YamamotoView Author Information Department of Chemistry, Graduate School of Science Tohoku University, Sendai 980-77, Japan Cite this: J. Am. Chem. Soc. 1997, 119, 34, 8113–8114Publication Date (Web):August 27, 1997Publication History Received19 May 1997Published online27 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971599ehttps://doi.org/10.1021/ja971599erapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1073Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Allyl group,Allylation,Anions,Catalysts,Hydrocarbons Get e-Alerts
Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase (1988)

Data on 405 patients with chronic myelogenous leukemia who received bone marrow transplants in chronic phase were analyzed for factors predictive of outcome. The 4-year actuarial probability of relapse was 19% (95% confidence interval [CI], 12% to 28%) and of survival, 55%. In multivariate analyses the probability of relapse was higher for recipients of T-cell-depleted bone marrow compared with recipients of non-T-cell-depleted bone marrow (relative risk, 5.4; P less than 0.0001) and for patients who did not develop chronic graft-versus-host disease (95% CI, 50% to 60%) with patients who did (relative risk, 3.1; P less than 0.01). The probability of survival was lower for patients who developed moderate to severe acute graft-versus-host disease than for patients with no or mild acute graft-versus-host disease (relative risk, 3.7; P less than 0.0001), and in patients aged 20 or older than in younger patients (relative risk, 2.6; P less than 0.0002). Duration of disease before transplant was not associated with outcome. Bone marrow transplantation done in the chronic phase of chronic myelogenous leukemia offers some patients prolonged leukemia-free survival. The T-cell-depleted grafts are associated with an increased probability of relapse.
[An ultrasonic scalpel for laparoscopic gynecologic surgery]. (1999)

In order to obtain good results in laparoscopic surgery the surgeon should be well trained and experienced and the equipment perfect. The recent innovation in laparoscopic surgery is the ultrasonically activated scalpel. Scissors make the working part of scalpel with one hand vibrating 55,000 Hz in a second. The effect reflects in braking hydrogen links and denaturation of proteins in instant haemostasis and coagulation in blood vessels, and there is no need of tying them up. Practically, there is no damaging of the surrounding tissues. The technique is easy to use. When performing laparoscopic vaginal hysterectomy and adnexectomy the ligamentum infundibulopelvicum and ligamentum rotundum are cut, and there the blood vessels are not thicker than 3 millimeters. As these ligaments are easy to reach with ultrasonically activated scalpel, we can say that this instrument is the ideal option for laparoscopic vaginal hysterectomy.