gebhart/patrepeval huggingface dataset:
Morphology and Properties of Pericytes (2010)

Pericytes were described in 1873 by the French scientist Charles-Marie Benjamin Rouget and were originally called Rouget cells. The Rouget cell was renamed some years later due to its anatomical location abluminal to the endothelial cell (EC) and luminal to parenchymal cells. In the brain, pericytes are located in precapillary arterioles, capillaries and postcapillary venules. They deposit elements of the basal lamina and are totally surrounded by this vascular component. Pericytes are important cellular constituents of the blood-brain barrier (BBB) and actively communicate with other cells of the neurovascular unit such as ECs, astrocytes, and neurons. Pericytes are local regulatory cells that are important for the maintenance of homeostasis and hemostasis, and are a source of adult pluripotent stem cells. Further understanding of the role played by this intriguing cell may lead to novel targeted therapies for neurovascular diseases.
Advances in Dilute Nitride Multi-Junction Solar Cells for Space Power Applications (2017)

A sub-cell with bandgap of around 1 eV is required to improve the efficiency of multi-junction solar cells beyond what is possible with legacy triple-junction architectures [1]. Solar Junction Corporation has been focused since 2007 on the development and commercialization of dilute nitride materials to be used as the 1eV sub-cell in a fully lattice matched multijunction solar cell. Initial focus on the terrestrial concentrating photovoltaics (CPV) market led to Solar Junction Corp.’s achievement of multiple world records in multi-junction solar cell efficiency with its triplejunction cells on GaAs [2], [3]. These solar cells have been available as commercial products since 2010. Solar Junction Corp. has leveraged its high-quality, manufacturable dilute nitride material to develop and introduce an entirely new class of space solar cells capable of reaching over 33% AM0 conversion efficiency in a four-junction (4J) configuration lattice matched to active Ge substrates, with a clear line of sight to 36% AM0 efficiency in five- or six-junction devices that can be manufactured more cost-effectively than devices relying on metamorphic technologies.
Comparison of foot orthoses made by podiatrists, pedorthists and orthotists regarding plantar pressure reduction in The Netherlands (2005)

The large variation for various aspects of foot orthoses therapy raises questions about a consistent use of concepts for pressures management within the professional groups.
Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool (2008)

In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activation are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of phosphatidylinositol 3-kinase (PI3K), the entire primordial follicle pool becomes activated. Subsequently, all primordial follicles become depleted in early adulthood, causing premature ovarian failure (POF). Our results show that the mammalian oocyte serves as the headquarters of programming of follicle activation and that the oocyte PTEN-PI3K pathway governs follicle activation through control of initiation of oocyte growth.
A Survey of the Statistical Theory of Shape (1989)

This is a review of the current state of the "theory of shape" introduced by the author in 1977. It starts with a definition of "shape" for a set of $k$ points in $m$ dimensions. The first task is to identify the shape spaces in which such objects naturally live, and then to examine the probability structures induced on such a shape space by corresponding structures in $\mathbf{R}^m$. Against this theoretical background one formulates and solves statistical problems concerned with shape characteristics of empirical sets of points. Some applications (briefly sketched here) are to archeology, astronomy, geography and physical chemistry. We also outline more recent work on "size-and-shape," on shapes of sets of points in riemannian spaces, and on shape-theoretic aspects of random Delaunay tessellations.
Anti-rheumatic drug-prescribing behaviour of Australasian rheumatologists 1984-1994 (1997)

The prescribing behaviour of Australian and New Zealand rheumatologists was studied in 1994 using a questionnaire, and the results compared with a similar questionnaire administered in 1984. Perceived differences in efficacy and toxicity for disease-modifying anti-rheumatic drugs (DMARDs) and cytotoxics were reported. Over the decade, methotrexate and sulphasalazine have become the most commonly used anti-rheumatic agents, and methotrexate is clearly seen as the most effective drug. Wide variations in monitoring practices for DMARDs were reported, highlighting the need for cost-effectiveness studies on monitoring. There was low usage of functional outcome measurements in assessing patients.
Capillary Electrochromatography with Predetermined Selectivity Obtained through Molecular Imprinting (1997)

This article presents a novel approach to capillary electrochromatography by which predetermined selectivity is achieved. A simple and quick method for the in situ preparation of monolithic molecularly imprinted flow-through polymers inside fused silica capillaries is described. The superporous structure of the polymers permits rapid solvent and electrolyte exchange, as well as easy regeneration of the capillaries by hydrodynamic pumping. Chiral stationary phases were prepared by molecular imprinting of the β-adrenergic antagonists propranolol and metoprolol. The separation systems were operational within 3 h of the start of capillary preparation. Chiral separations with baseline resolution could be carried out in less than 120 s.
Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. (1992)

Overexpression of sequences corresponding to the major Rev-binding site in the Rev response element of human immunodeficiency virus type 1 (HIV-1) (RRE decoys) was used to render cells resistant to HIV-1 replication. This was accomplished by the use of a chimeric tRNA-RRE transcription unit in a double-copy murine retroviral vector to express high levels of HIV-1 RRE-containing transcripts in CEM SS cells. Replication of HIV-1 was inhibited more than 90% in cells expressing chimeric tRNA-RRE transcripts, as determined by in situ immunofluorescence analysis and a p24 antigen ELISA test. Analysis of RNA from HIV-1-infected cells suggests that expression of RRE-containing sequences in CEM SS cells inhibits HIV-1 replication by interfering with Rev function, presumably by competing for Rev binding to its physiological target. The use of a subfragment of RRE as decoy RNA reduces the likelihood that essential cellular factors will be sequestered in cells expressing the decoy RNA. Thus, use of RRE-based decoy RNA to inhibit HIV-1 replication may represent a safer alternative to the use of TAR decoy RNA.
The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells (2006)

Histamine is an important inflammatory mediator that is released in airways during an asthmatic response. However, current antihistamine drugs are not effective in controlling the disease. The discovery of the histamine H4 receptor (H4R) prompted us to reinvestigate the role of histamine in pulmonary allergic responses. H4R-deficient mice and mice treated with H4R antagonists exhibited decreased allergic lung inflammation, with decreases in infiltrating lung eosinophils and lymphocytes and decreases in Th2 responses. Ex vivo restimulation of T cells showed decreases in IL-4, IL-5, IL-13, IL-6, and IL-17 levels, suggesting that T cell functions were disrupted. In vitro studies indicated that blockade of the H4R on dendritic cells leads to decreases in cytokine and chemokine production and limits their ability to induce Th2 responses in T cells. This work suggests that the H4R can modulate allergic responses via its influence on T cell activation. The study expands the known influences of histamine on the immune system and highlights the therapeutic potential of H4R antagonists in allergic conditions.
Heterotopic Ossification After Hip and Knee Arthroplasty: Risk Factors, Prevention, and Treatment (2002)

Symptomatic heterotopic ossification (HO) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) is relatively rare. Patients at high risk for developing HO after THA include men with bilateral hypertrophic osteoarthritis, patients with a history of HO in either hip, and patients with posttraumatic arthritis characterized by hypertrophic osteophytosis. Patients at moderate risk are those with ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis, Paget's disease, or unilateral hypertrophic osteoarthritis. Patients at high risk for developing HO after TKA include those with limited postoperative knee flexion, increased lumbar bone mineral density, hypertrophic arthrosis, excessive periosteal trauma and/or notching of the anterior femur, and those who require forced manipulation after TKA. Preoperative radiation is effective for preventing HO after THA, as are post-operative prophylactic drug regimens and single-dose radiation treatments. Recurrence of HO after surgical excision should be expected unless prophylaxis is administered. Prophylactic measures against HO after THA and TKA should be administered before the fifth postoperative day, optimally within 24 to 48 hours.
Integrating task and data parallelism with the group communication archetype (2002)

A parallel program archetype aids the development of reliable, efficient parallel applications with common computation/communication structures by providing stepwise refinement methods and code libraries specific to the structure. The methods and libraries help in transforming a sequential program into a parallel program via a sequence of refinement steps that help maintain correctness while refining the program to obtain the appropriate level of granularity for a target machine. The specific archetype discussed deals with the integration of task and data parallelism using group communication. This archetype has been used to develop several applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
PREDICTING THE FUTURE: A CONNECTIONIST APPROACH (1990)

We investigate the effectiveness of connectionist architectures for predicting the future behavior of nonlinear dynamical systems. We focus on real-world time series of limited record length. Two examples are analyzed: the benchmark sunspot series and chaotic data from a computational ecosystem. The problem of overfitting, particularly serious for short records of noisy data, is addressed both by using the statistical method of validation and by adding a complexity term to the cost function ("back-propagation with weight-elimination"). The dimension of the dynamics underlying the time series, its Liapunov coefficient, and its nonlinearity can be determined via the network. We also show why sigmoid units are superior in performance to radial basis functions for high-dimensional input spaces. Furthermore, since the ultimate goal is accuracy in the prediction, we find that sigmoid networks trained with the weight-elimination algorithm outperform traditional nonlinear statistical approaches.
Synthesis and Characterization of Pyridine‐Based Polybenzimidazoles for High Temperature Polymer Electrolyte Membrane Fuel Cell Applications (2005)

Abstract A series of polybenzimidazoles (PBIs) incorporating main chain pyridine groups were synthesized from the pyridine dicarboxylic acids (2,4‐, 2,5‐, 2,6‐ and 3,5‐) and 3,3′,4,4′‐tetraaminobiphenyl, using polyphosphoric acid (PPA) as both solvent and polycondensation reagent. A novel process, termed the PPA process, has been developed to prepare phosphoric acid (PA) doped PBI membranes by direct‐casting of the PPA polymerization solution without isolation or re‐dissolution of the polymers. The subsequent hydrolysis of PPA to PA by moisture absorbed from the atmosphere usually induced a transition from the solution state to a gel‐like state and produced PA‐doped PBI membranes with a desirable suite of physiochemical properties. The polymer structure characterization included inherent viscosity (I.V.) determination as a measurement of polymer molecular weight and thermal stability assessment via thermogravimetric analysis. Physiochemical properties of the doped membrane were studied by measurements of the PA doping level, ionic conductivity and mechanical properties. The resulting pyridine‐based polybenzimidazole membranes displayed high PA doping levels, ranging from 15 to 25 mol of PA per PBI repeat unit, which contributed to their unprecedented high proton conductivities of 0.1 to 0.2 S cm –1 at 160 °C. The mechanical property measurements showed that the pyridine‐based PBI membranes were thermally stable and maintained mechanical integrity even at high PA doping levels. Preliminary fuel cell tests demonstrated the feasibility of the novel pyridine‐based PBI (PPBI) membranes from the PPA process for operating fuel cells at temperatures in excess of 120 °C without any external humidification.
Tight-binding description of graphene (2002)

We investigate the tight-binding approximation for the dispersion of the $\ensuremath{\pi}$ and ${\ensuremath{\pi}}^{*}$ electronic bands in graphene and carbon nanotubes. The nearest-neighbor tight-binding approximation with a fixed ${\ensuremath{\gamma}}_{0}$ applies only to a very limited range of wave vectors. We derive an analytic expression for the tight-binding dispersion including up to third-nearest neighbors. Interaction with more distant neighbors qualitatively improves the tight-binding picture, as we show for graphene and three selected carbon nanotubes.
Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going? (2002)

Many human tumor-associated antigens (TAAs) have recently been identified and molecularly characterized. When bound to major histocompatibility complex molecules, TAA peptides are recognized by T cells. Clinical studies have therefore been initiated to assess the therapeutic potential of active immunization or vaccination with TAA peptides in patients with metastatic cancer. So far, only a limited number of TAA peptides, mostly those recognized by CD8(+) T cells in melanoma patients, have been clinically tested. In some clinical trials, partial or complete tumor regression was observed in approximately 10%-30% of patients. No serious side effects have been reported. The clinical responses, however, were often not associated with a detectable T-cell-specific antitumor immune response when patients' T cells were evaluated in ex vivo assays. In this review, we analyze the available human TAA peptides, the potential immunogenicity (i.e., the ability to trigger a tumor-specific T-cell response) of TAA peptides in vitro and ex vivo, and the potential to construct slightly modified forms of TAA peptides that have increased T-cell stimulatory activity. We discuss the available data from clinical trials of TAA peptide-based vaccination (including those that used dendritic cells to present TAA peptides), identify possible reasons for the limited clinical efficacy of these vaccines, and suggest ways to improve the clinical outcome of TAA peptide-based vaccination for cancer patients.
A SENSITIVE ASSAY FOR MEASURING ??-GAL EPITOPE EXPRESSION ON CELLS BY A MONOCLONAL ANTI-GAL ANTIBODY1 (1998)

The mouse IgM M86 monoclonal antibody was highly specific for a-gal epitopes. Using this antibody in an ELISA inhibition assay with cells at a wide range of concentrations enables the detection of at least 5 x 10(4) and up to more than 5 x 10(7) a-gal epitopes per cell. This assay can be used also for the detection of a-gal epitopes on membranes from tissue homogenates, and thus it enables the determination of the extent of decrease in a-gal epitope expression in animals that are genetically manipulated to alter their carbohydrate make-up.
Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force (2007)

The undesired movement of anchor teeth, and relapse of previously moved teeth, are major clinical problems in orthodontics. Dental implants are increasingly used to preserve anchorage, but these are costly and require invasive surgical procedures. An alternative strategy for maintaining anchorage may be the use of biological inhibitors of osteoclastic bone resorption. In the present study, we investigated the relative efficacy of pamidronate vs. osteoprotegerin (OPG) in inhibiting bone resorption and tooth movement, using a new orthodontic model in mice in which maxillary molars are moved for prolonged periods by near-constant, clinically relevant forces. Osteoclast influx to compression sites was initiated on day 3, was maximal on day 4, and persisted until at least day 12 after force application. Tooth movement paralleled osteoclast numbers. Minimal osteoclast apoptosis was observed, suggesting that recruitment, rather than programmed cell death, is a critical regulatory mechanism under conditions of constant force. Osteoclasts were reduced at compression sites by both OPG (95%) and pamidronate (70%); tooth movement was more dramatically inhibited by OPG (77% vs. 34%). Our findings indicate that constant orthodontic force regulates the recruitment, activation, and viability of osteoclasts, and that OPG could have clinical utility in preventing undesired tooth movement.
Hatchery Spray Cabinet Administration Does Not Damage Avian Coronavirus Infectious Bronchitis Virus Vaccine Based on Analysis by Electron Microscopy and Virus Titration (2015)

studies in our laboratory showed that the Arkansas-Delmarva Poultry Industry (Ark-DPI) vaccine given to 1-day-old chickens by hatchery spray cabinet replicated poorly and failed to adequately protect broilers against homologous virus challenge, whereas the same vaccine given by eye-drop did replicate and the birds were protected following homologous virus challenge. To determine if mechanical damage following spray application plays a role in failure of the Ark-DPI vaccine, we examined the morphology of three Ark-DPI vaccines from different manufacturers using an electron microscope and included a Massachusetts (Mass) vaccine as control. One of the Ark-DPI vaccines (vaccine A) and the Mass vaccine had significantly (P < 0.005) fewer spikes than the other two Ark-DPI vaccines. We also found that the Ark-DPI and Mass vaccines had significantly (P < 0.005) fewer spike proteins per virus particle when compared to their respective challenge viruses. This observation is interesting and may provide some insight into the mechanism behind infectious bronchitis virus attenuation. No obvious differences were observed in virus morphology and no consistent trend in the number of spikes per virion was found in before- and after-spray samples. We also determined the vaccine titer before and after spray in embryonated eggs and found that both Ark-DPI and Mass vaccines had a similar drop in titer, 0.40 logi and 0.310 logi, respec10ively. Based on these data, it appears that mechanical damage to the Ark-DPI vaccine is not occurring when delivered by a hatchery spray cabinet, suggesting that some other factor is contributing to the failure of that vaccine when given by that method.
美国的不景气现象：消费者为何如此不满——怎样才能改变这种状况？ (1993)

目前美国最普遍的心理障碍可能是针对经济的恐慌。据多数测算，美国人现在对经济的沮丧程度仍和前几年一样。专门测算消费者对经济看法和前景的会议理事会消费者信心月统计指数最近降到了46．3，是1974年12月以来的最低点。在最近5个月中，消费者信心指数急剧下降了1／3。
Prader-Willi syndrome: A primer for clinicians (2011)

The advent of sensitive genetic testing modalities for the diagnosis of Prader-Willi syndrome has helped to define not only the phenotypic features of the syndrome associated with the various genotypes but also to anticipate clinical and psychological problems that occur at each stage during the life span. With advances in hormone replacement therapy, particularly growth hormone children born in circumstances where therapy is available are expected to have an improved quality of life as compared to those born prior to growth hormone.This manuscript was prepared as a primer for clinicians-to serve as a resource for those of you who care for children and adults with Prader-Willi syndrome on a daily basis in your practices. Appropriate and anticipatory interventions can make a difference.
Assembly of Bimetallic Gold−Silver Nanoparticles via Selective Interparticle Dicarboxylate−Silver Linkages (2005)

This article describes findings of an investigation of the thin-film assembly of binary metal nanoparticles via interparticle linkages of dicarboxylic acid mediators at selective metal sites. Decanethiol- (DT-) capped gold−silver (Au−Ag) alloy nanoparticles of ∼3-nm core sizes were chosen as a model system because of the unique carboxylate−Ag+ binding chemistry and the well-defined thiolate-capping capability at Au. The dicarboxylate-mediated thin-film assembly of Au−Ag nanoparticles was characterized using UV−vis, TEM, XPS, FTIR, and NMR techniques. The results from controlling the oxidative or reductive conditions reveal that the oxidation of Ag to Ag+ on the alloy nanocrystal surface played an important role in the selective ligand exchange and interparticle linkage by dicarboxylic acids (e.g., hexadecanedioic acid, HDA). The formation of the thin-film assembly is dependent on both the alloy composition of the Au−Ag nanoparticles and the chain length of the dicarboxylic acids. The degree for an HDA−DT/Au−Ag exchanging and linking system is determined to yield a value of 16% of DTs per Au−Ag particle being displaced by HDAs. In comparison to similar thin-film assemblies of Au−Ag and Au nanoparticles by other mediators, the results support the conclusion that the HDA-mediated assembly of Au−Ag nanoparticles occurs via −CO2-−Ag+ linkages at silver sites forming a mediator (HDA)−template (DT) nanostructure. The nanostructured thin-film assemblies exhibit interesting optical and electronic properties, which have important implications for the exploration of binary nanoparticle-structured materials for sensing and catalytic applications where fine-tuning of either the binary nanocrystal cores or the bifunctional interparticle structures is desired.
Production of Chymotrypsin-Resistant Bacillus thuringiensis Cry2Aa1 δ-Endotoxin by Protein Engineering (1999)

Cleavage of the Cry2Aa1 protoxin (molecular mass, 63 kDa) from Bacillus thuringiensis by midgut juice of gypsy moth (Lymantria dispar) larvae resulted in two major protein fragments: a 58-kDa fragment which was highly toxic to the insect and a 49-kDa fragment which was not toxic. In the midgut juice, the protoxin was processed into a 58-kDa toxin within 1 min, but after digestion for 1 h, the 58-kDa fragment was further cleaved within domain I, resulting in the protease-resistant 49-kDa fragment. Both the 58-kDa and nontoxic 49-kDa fragments were also found in vivo when (125)I-labeled toxin was fed to the insects. N-terminal sequencing revealed that the protease cleavage sites are at the C termini of Tyr49 and Leu144 for the active fragment and the smaller fragment, respectively. To prevent the production of the nontoxic fragment during midgut processing, five mutant proteins were constructed by replacing Leu144 of the toxin with Asp (L144D), Ala (L144A), Gly (L144G), His (L144H), or Val (L144V) by using a pair of complementary mutagenic oligonucleotides in PCR. All of the mutant proteins were highly resistant to the midgut proteases and chymotrypsin. Digestion of the mutant proteins by insect midgut extract and chymotrypsin produced only the active 58-kDa fragment, except that L144H was partially cleaved at residue 144.