gebhart/patrepeval huggingface dataset:
Triglyceride-Rich Lipoproteins as Agents of Innate Immunity (2005)

Bacterial endotoxin (i.e., lipopolysaccharide [LPS]) elicits dramatic responses in the host, including elevated plasma lipid levels due to increased synthesis and secretion of triglyceride-rich lipoproteins by the liver and inhibition of lipoprotein lipase. This cytokine-induced hyperlipoproteinemia, clinically termed the "lipemia of sepsis," was customarily thought to involve the mobilization of lipid stores to fuel the host response to infection. However, because lipoproteins can also bind and neutralize LPS, we have long postulated that triglyceride-rich lipoproteins (very-low-density lipoproteins and chylomicrons) are also components of an innate, nonadaptive host immune response to infection. Recent research demonstrates the capacity of lipoproteins to bind LPS, protect against LPS-induced toxicity, and modulate the overall host response to this bacterial toxin.
Determining the binding affinities of phenolic compounds to proteins by quenching of the intrinsic tryptophan fluorescence (2006)

The noncovalent binding of selected phenolic compounds (chlorogenic-, ferulic-, gallic acid, quercetin, rutin, and isoquercetin) to proteins (HSA, BSA, soy glycinin, and lysozyme) was studied by an indirect method applying the quenching of intrinsic tryptophan fluorescence. From the data obtained, the binding constants were calculated by nonlinear regression (one site binding; y = Bx/k + x). It has been reported that tannins inhibit human salivary amylase and that these complexes may reduce the development of cariogenic plaques. Further, amylase contains two tryptophan residues in its active site. Therefore, in a second part of the study involving 31 human subjects, evidence was sought for noncovalent interactions between the phenols of green tea and saliva proteins as measured by the fluorescence intensity. Amylase activity was determined before and after the addition of green tea to saliva of 31 subjects. Forty percent of the subjects showed an increase in amylase activity contrary to studies reporting only a decrease in activity. The interactions of tannin with amylase result in a decrease of its activity. It still remains to be elucidated why amylase does not react uniformly under conditions of applying green tea to saliva. Further, in terms of using phenols as caries inhibitors this finding should be of importance.
Heterogeneously catalyzed strategies for the deconstruction of high density polyethylene: plastic waste valorisation to fuels (2014)

Waste to energy: catalytic degradation of plastic waste can provide valuable energy carriers.
Ultrathin Gold Nanowires Can Be Obtained by Reducing Polymeric Strands of Oleylamine−AuCl Complexes Formed via Aurophilic Interaction (2008)

This Communication describes a facile route to the preparation of ultrathin gold nanowires using linear chains formed from [(oleylamine)AuCl] complex via aurophilic interaction. The linear chains, with AuI...AuI bonds as the backbone and surrounded by oleylamines, can group together to form bundles of polymeric strands. When the AuI was reduced to Au0 by reacting with Ag nanoparticles in hexane, the polymeric strands functioned as both the source of Au and the template to mediate the nucleation and growth of Au nanowires. Using this method, we were able to produce Au nanowires with an average diameter of approximately 1.8 nm and an aspect ratio of >1000 in high yields (approximately 70%).
A Review on Graph Based Segmentation (2012)

Image segmentation plays a crucial role in effective understanding of digital images. Past few decades saw hundreds of research contributions in this field. However, the research on the existence of general purpose segmentation algorithm that suits for variety of applications is still very much active. Among the many approaches in performing image segmentation, graph based approach is gaining popularity primarily due to its ability in reflecting global image properties. This paper critically reviews existing important graph based segmentation methods. The review is done based on the classification of various segmentation algorithms within the framework of graph based approaches. The major four categorizations we have employed for the purpose of review are: graph cut based methods, interactive methods, minimum spanning tree based methods and pyramid based methods. This review not only reveals the pros in each method and category but also explores its limitations. In addition, the review highlights the need for creating a database for benchmarking intensity based algorithms, and the need for further research in graph based segmentation for automated real time applications.
Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring. (1992)

Chaperonins are thought to participate in the process of protein folding in bacteria and in eukaryotic mitochondria and chloroplasts. While some chaperonins are relatively well characterized, the structures of the mammalian chaperonins are unknown. We have expressed a mammalian mitochondrial chaperonin 60 in Escherichia coli and purified the recombinant protein to homogeneity. Structural and biochemical analyses of this protein establish a single toroidal structure of seven subunits, in contrast to the homologous bacterial, fungal, and plant chaperonin 60s, which have double toroidal structures comprising two layers of seven identical subjects each. The recombinant mammalian chaperonin 60, together with the mammalian chaperonin 10 (but not with bacterial chaperonin 10), facilitates the formation of catalytically active ribulose-bisphosphate carboxylase from an unfolded state in the presence of K+ and MgATP. Analysis of the partial reactions involved in this in vitro reconstitution reveals that the single toroid of chaperonin 60 can form stable complexes with both unfolded or partially folded [35S]ribulose-bisphosphate carboxylase and mitochondrial (but not bacterial) chaperonin 10 in the presence of MgATP. We conclude that the minimal functional unit of chaperonin 60 is a single hepatmeric toroid.
Field Evaluation of Transgenic Tobacco Containing a Bacillus thuringiensis Insecticidal Protein Gene (1992)

Journal Article Field Evaluation of Transgenic Tobacco Containing a Bacillus thuringiensis Insecticidal Protein Gene Get access Gregory W. Warren, Gregory W. Warren Plant Molecular Biology, CIBA-GEIGY Agricultural Biotechnology Research Unit, Research Triangle Park, NC 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nadine B. Carozzi, Nadine B. Carozzi Plant Molecular Biology, CIBA-GEIGY Agricultural Biotechnology Research Unit, Research Triangle Park, NC 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nalini Desai, Nalini Desai Plant Molecular Biology, CIBA-GEIGY Agricultural Biotechnology Research Unit, Research Triangle Park, NC 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Koziel Michael Koziel Plant Molecular Biology, CIBA-GEIGY Agricultural Biotechnology Research Unit, Research Triangle Park, NC 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 85, Issue 5, 1 October 1992, Pages 1651–1659, https://doi.org/10.1093/jee/85.5.1651 Published: 01 October 1992 Article history Received: 20 May 1991 Accepted: 30 March 1992 Published: 01 October 1992
Prognostic Value of Vascular Endothelial Growth Factor in Breast Cancer (2000)

Angiogenesis, the process leading to the formation of new blood vessels from a preexisting vascular network, is necessary for tumor growth, invasion, and metastasis. Data from experimental and clinical studies indicate that breast carcinoma is an angiogenesis-dependent tumor. Most retrospective studies evaluating the prognostic value of determination of intratumoral microvessel density (IMD) at the vascular "hot spot" (a surrogate marker of angiogenesis) found that IMD is a significant and independent prognostic indicator in patients with both node-negative and node-positive breast cancers. More recently, the expression of certain endothelial growth factors has been tested. Among these, vascular endothelial growth factor (VEGF), the most potent endothelial cell mitogen and also a regulator of vascular permeability, is emerging as a powerful new prognostic tool. Eight of the nine published retrospective studies reported that VEGF is significantly associated with relapse-free survival, overall survival, or both. Patients with early stage breast cancer who have tumors with elevated levels of VEGF have a higher likelihood of recurrence or death than patients with low-angiogenic tumors, even if treated with conventional adjuvant therapy. High levels of VEGF can differentiate the subgroups of patients with breast cancer with poor prognosis who benefit minimally from conventional adjuvant therapy but who may benefit from validated anti-VEGF treatments.
Catheter Technique for Recording His Bundle Activity in Man (1969)

A technique for the routine recording of His bundle (H) activity in man using a bipolar or multipolar catheter is described. The recording catheter is inserted percutaneously, via the Seldinger method, into the right femoral vein and advanced fluoroscopically into the right atrium. Placement of the pre-formed curve at the catheter tip across the tricuspid valve in nine patients resulted in stable recordings of His bundle activity in successive cardiac cycles. Right atrial pacing resulted in progressive lengthening of the P-H interval with increasing frequency but the H to S-wave interval remained constant at all rates. Similar lengthening of the P-H interval was produced during atrial pacing when pressure was applied to the carotid sinus. The use of this recording technique in man will facilitate diagnostic interpretation of the electrocardiogram and can be used in various investigations of atrioventricular and intraventricular conduction in man.
Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy. (2001)

Analysis of 1,060 xenotransplants derived from cancer cell lines as wel as spontaneously occurring tumors from the larynx, pharynx, mammary gland, uterine cervix, and vulva revealed that tumor regression induced by treatment with monoclonal antibodies (EMD 55900 and EMD 72000 against the epidermal growth factor receptor (EGFR) could be enhanced by tumor necrosis factor alpha (TNF-alpha) treatment in vivo. Moreover, tumor that primarily do not respond to antibody treatment can be made suscep tible by additional TNF-alpha treatment. To investigate the in vivo effects of monoclonal antibodies, we treated tumors derived from cell lines (A431 and Detroit 562) as well as spontaneously occurring squamous cell carci nomas and adenocarcinomas (transplanted on NMRI-nu/nu mice) gener ally with EMD 55900 (40 microg/g mouse) and its humanized version EMD 72000 (40 microg/g mouse). When treated with EMD 55900 and EMD 72000 carcinomas with an EGFR concentration of > or = 70 fmol/mg protein showed significant reduction in tumor size compared with untreated controls. The degree of tumor regression correlated with the EGFR concentration of the tumor. In mice treated with TNF-alpha (0.5 microg/g mouse) and EMD 55900 72000 simultaneously, we observed enhanced antitumor effects up to complete tumor eradication. Carcinomas with an EGFR concentration <70 fmol/mg protein could be made susceptible to treatment with EMD 55900 and EMD 72000 by simultaneous treatment with TNF-alpha, resulting in a significant reduction in tumor size.
Non-contract Estimation of Respiration and Heartbeat Rate using Ultra-Wideband Signals (2008)

The use of ultra-wideband (UWB) signals holds great promise for remote monitoring of vital-signs which has applications in the medical, for first responder and in security. Previous research has shown the feasibility of a UWB-based radar system for respiratory and heartbeat rate estimation. Some simulation and real experimental results are presented to demonstrate the capability of the respiration rate detection. However, past analysis are mostly based upon the assumption of an ideal experiment environment. The accuracy of the estimation and interference factors of this technology has not been investigated. This thesis establishes an analytical framework for the FFT-based signal processing algorithms to detect periodic bio-signals from a single target. Based on both simulation and experimental data, three basic challenges are identified: (1) Small body movement during the measurement interval results in slow variations in the consecutive received waveforms which mask the signals of interest. (2) The relatively strong respiratory signal with its harmonics greatly impact the detection of heartbeat rate. (3) The non-stationary nature of bio-signals creates challenges for spectral analysis. Having identified these problems, adaptive signal processing techniques have been developed which effectively mitigate these problems. Specifically, an ellipse-fitting algorithm is adopted to track and compensate the aperiodic large-scale body motion, and a wavelet-based filter is applied for attenuating the interference caused by respiratory harmonics to accurately estimate the heartbeat frequency. Additionally, the spectrum estimation of non-stationary signals is examined using a different transform method. Results from simulation and experiments show that substantial improvement is obtained by the use of these techniques. Further, this thesis examines the possibility of multi-target detection based on the same measurement setup. Array processing techniques with subspace-based algorithms are applied to estimate multiple respiration rates from different targets. The combination of array processing and single- target detection techniques are developed to extract the heartbeat rates. The performance is examined via simulation and experimental results and the limitation of the current measurement setup is discussed.
Comparison of Apolipoprotein and Proteoglycan Deposits in Human Coronary Atherosclerotic Plaques (1998)

These results suggest that biglycan may bind apoE and apoB in atherosclerotic intima. They also raise the possibility that apoE may act as a "bridging" molecule that traps apoA-I-containing HDL in atherosclerotic intima. Taken together, these findings are consistent with the hypothesis that biglycan may contribute to the pathogenesis of atherosclerosis by trapping lipoproteins in the artery wall.
Human bone marrow stroma-dependent myeloma sister cell lines MOLP-6 and MOLP-7 derived from a patient with multiple myeloma. (2000)

Human bone marrow stroma (BST)-dependent myeloma sister cell lines MOLP-6 and MOLP-7 were established from the peripheral blood of a multiple myeloma (MM) patient with IgA kappa type MM (stage IIIB). The growth of the cell lines is constitutively dependent on BST cells; none of the cytokines tested nor the culture supernatant of the BST cells could support the growth. Both cell lines showed typical plasma cell morphology with abundant cytoplasm and one to four nuclei under Wright staining. The immunoprofiles of MOLP-6 and MOLP-7 correspond to that seen typically in primary MM cells: positive for cytoplasmic immunoglobulin (Ig) chains, a heavy and kappa light chains, CD9, CD28, CD40, CD44, CD45, CD56, and PCA-1; the cells were negative for surface Igs and various other B-cell, T-cell and myelomonocyte associated markers. Both cell lines also expressed adhesion molecules including HCAM (CD44), VLA-4 (CD49d/CD29), VLA-6 (CD49f/CD29), ICAM-1 (CD54), NCAM (CD56), LFA-3 (CD58) and L-selectin (CD62L). The doubling time of MOLP-6 and MOLP-7 was 48 and 168 hours, respectively. In addition to this growth characteristic, the maximum cell density of each cell line was obtained at 1.7 x 10(6) cells/ml and 9.7 x 10(5) cells/ml, respectively. The characteristics of each cell line may reflect intraclonal variation of the proliferative capacity. The MOLP-6 together with the MOLP-7 sister will be useful model systems for the investigation of the biology of myeloma.
Synthesis of Norbornenyl Polymers with Bioactive Oligopeptides by Ring-Opening Metathesis Polymerization (2000)

Synthetic norbornenyl polymers with pendent cell adhesive sequences glycine-arginine-glycine-aspartic acid (GRGD) and serine-arginine-asparagine (SRN) were synthesized by ring-opening metathesis polymerization (ROMP) using newly developed ruthenium initiators. Initially, simpler polymers with pendent glycine, alanine, or penta(ethylene glycol) (EO5) units attached directly or through ethyl and propyl spacers to various norbornenyl backbones were synthesized using RuCHPh(Cl)2(PCy3)2 (1) as the initiator. The molecular weights, PDI's, polymerization times, yields, and glass transition temperatures were compared for these polymers. As a result of this comparison, poly(5-norbornene-2-carboxyl) was chosen as the backbone for the more complex oligopeptide containing polymers, and norbornene monomers with pendent EO5 (21), GRGD (24), and SRN (25) units were made. Monomers 21 and 24 were copolymerized to form a poly(norbornene) containing 9.2 mol % GRGD (26a) using 1 as the initiator. However, incorporating larger amounts of GRGD resulted in extremely low yields of polymers that exhibited bimodal molecular weight distributions. Homopolymers and copolymers with larger amounts of GRGD and SRN were synthesized in good yields (32−92%) with monomodal molecular weight distributions using the newly developed, more active, 2,3-dihydroimidazolylidene initiators, RuCHPh(Cl)2(PCy3)(DHIMes) (2) and RuCH−CHC(CH3)2(Cl)2(PCp3)(DHIMes) (3). In this way, EO5 containing copolymers with 49 mol % GRGD (26b), 53 mol % SRN (27b), or 32 mol % GRGD and 21 mol % SRN (28a) were synthesized, as well as copolymer 28b with 53 mol % GRGD and 47 mol % SRN. To alter the presentation of the GRGD, an EO5 containing copolymer with a propyl spacer between the GRGD and the backbone (30) was also synthesized.
Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid (1997)

Dehydroascorbic acid (DHA) is rapidly taken up by cells and reduced to ascorbic acid (AA). Using the Xenopus laevis oocyte expression system we examined transport of DHA and AA via glucose transporter isoforms GLUT1-5 and SGLT1. The apparent Km of DHA transport via GLUT1 and GLUT3 was 1.1 +/- 0.2 and 1.7 +/- 0.3 mM, respectively. High performance liquid chromatography analysis confirmed 100% reduction of DHA to AA within oocytes. GLUT4 transport of DHA was only 2-4-fold above control and transport kinetics could not be calculated. GLUT2, GLUT5, and SGLT1 did not transport DHA and none of the isoforms transported AA. Radiolabeled sugar transport confirmed transporter function and identity of all cDNA clones was confirmed by restriction fragment mapping. GLUT1 and GLUT3 cDNA were further verified by polymerase chain reaction. DHA transport activity in both GLUT1 and GLUT3 was inhibited by 2-deoxyglucose, D-glucose, and 3-O-methylglucose among other hexoses while fructose and L-glucose showed no inhibition. Inhibition by the endofacial inhibitor, cytochalasin B, was non-competitive and inhibition by the exofacial inhibitor, 4,6-O-ethylidene-alpha-glucose, was competitive. Expressed mutant constructs of GLUT1 and GLUT3 did not transport DHA. DHA and 2-deoxyglucose uptake by Chinese hamster ovary cells overexpressing either GLUT1 or GLUT3 was increased 2-8-fold over control cells. These studies suggest GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA.
A generic system for processing invoices (2002)

This paper presents a generic system which automatically extracts the requested items from invoices with arbitrary form layout in arbitrary domains. The system consists of two components, an OCR tool which need not be adapted to the current domain and an information extraction component FRESCO which contains the knowledge about the domain. The automation rate for interpreting invoices in the domain of health insurance is above 50% with an error rate below 1% with respect to the items to be extracted.
Image replacement through texture synthesis (2002)

Photographs and images often have regions which are in some sense flawed. Often, there may be a stain or an undesired feature covering a significant portion of the image, and an algorithm that can "fix" the image is desired. We propose a technique based on Heeger and Bergen's texture synthesis algorithm (1995). By integrating a composition step into the aforementioned algorithm one portion of the image can be substituted with a synthetic texture derived from another portion of the image. The goal of this synthetic texture is to create a plausible patch without visible seams or repetitive features. We compare this technique, which works on areas that are "stochastic" in nature, with other variations of image replacement which utilize a combination of image composition and texture synthesis.
Adaptive interaction for enabling pervasive services (2001)

We describe an architecture that allows mobile users to access a variety of services provided by pervasive computing environments. Novel to our approach is that the system selects and executes services taking into account arbitrary contextual information (e.g. location or preferences). Our architecture is based on an adaptive service interaction scheme; individual service requests are attributed by context constraints, which specify the adaption policy. Context constraints may relate to spatial or temporal concerns. We propose a document-based approach; so called Context-Aware Packets (CAPs) contain context constraints and data for describing an entire service request. Intermediary network nodes route and apply the data to services, which match the embedded constraints. Services are identified by characterizing attributes, rather then explicit network addresses. The execution of selected services may be deferred, and triggered by a specific event. Service requests carry the context of their use, therefore our system works well in environments with intermitted connectivity, less interaction with the issuing requester is required.
Crosstalk and switching characteristics in directional couplers (1988)

The normal mode approach is used to calculate the fundamental limits on crosstalk and switching characteristics in directional coupler switches of the stepped delta beta type. The normal modes are calculated numerically as well as analytically using a method for computing the eigenmodes of two coupled, identical waveguides with an antisymmetric index perturbation. The results of the two methods are compared to one another as well as to the results of coupled-mode theory. It is shown that the theoretical minimum for the crosstalk level is very low for the stepped delta beta structure. Nonzero crosstalk was found in some cases where coupled-mode theory predicts zero crosstalk. This is attributed to the improper handling of discontinuities in coupled-mode theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Subtopic structuring for full-length document access (1993)

We argue that the advent of large volumes of full-length text, as opposed to short texts like abstracts and newswire, should be accompanied by corresponding new approaches to information access. Toward this end, we discuss the merits of imposing structure on full-length text documents; that is, a partition of the text into coherent multi-paragraph units that represent the pattern of subtopics that comprise the text. Using this structure, we can make a distinction between the main topics, which occur throughout the length of the text, and the subtopics, which are of only limited extent. We discuss why recognition of subtopic structure is important and how, to some degree of accuracy, it can be found. We describe a new way of specifying queries on full-length documents and then describe an experiment in which making use of the recognition of local structure achieves better results on a typical information retrieval task than does a standard IR measure.