gebhart/patrepeval huggingface dataset:
Diet and Breast Cancer (1992)

It is a general opinion that the Western diet plays a significant role in increasing the risk of breast cancer in the Western World. Recently some likely mechanisms involved in increasing the risk have been disclosed. It has been found that a Western-type diet elevates plasma levels of sex hormones and decreases the sex hormone binding globulin concentration, increasing the availability of these steroids for peripheral tissues. The same diet results in low formation by intestinal bacteria of mammalian lignans and isoflavonoid phyotestrogens from plant precursors. These diphenolic compounds seem to affect hormone metabolism and production and cancer cell growth by many different mechanisms making them strong candidates for a role as cancer protective substances. The sex hormone pattern found in connection with a Western-type diet combined with low lignan and isoflavonoid excretion was found particularly in postmenopausal breast cancer patients and omnivores living in high-risk areas, and to a lesser degree in areas with less risk. However, the pattern observed was not entirely due to diet.
Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids (1991)

Scrapie can be transmitted by novel infectious pathogens termed prions. No evidence for a scrapie-specific nucleic acid has been detected to date. To investigate amounts, types and sizes of nucleic acid molecules associated with prions in purified preparations, aliquots were deproteinized, and the nucleic acids analysed by PAGE and silver staining. Digestion with nucleases and exposure to Zn2+ prior to analysis substantially diminished the content of nucleic acids, but did not alter the prion titre indicating that those nucleic acids which were removed are not essential for infectivity. Since a single species of scrapie-specific nucleic acid could not be identified, we explored the unprecedented possibility of scrapie-specific nucleic acids of variable length which are biologically active. If such molecules of variable length exist then they might be hidden within the background smear on silver-stained gels after PAGE. A new procedure designated return refocusing gel electrophoresis (RRGE) was developed to identify heterogeneous nucleic acids in purified prion fractions. The content of variable length nucleic acids was reduced by a factor of 10 by exhaustive Bal 31 exonuclease digestion after dispersion of purified prions into detergent-lipid-protein complexes. For example, a typical sample after Bal 31 digestion contained approximately 4 ng of nucleic acid of variable length and 10(8.7) ID50 units of scrapie prion infectivity. Consideration of different models for a hypothetical scrapie-specific nucleic acid suggests that such a molecule would have to be: (i) quite small (less than 100 nucleotides), (ii) possess a particle-to-infectivity ratio near unity or (iii) heterogeneous in size. Although our results do not eliminate the possibility that prions possess a scrapie-specific nucleic acid of variable length, they narrow considerably the spectrum of features specifying such a candidate molecule.
Optimal and efficient merging schedules for video-on-demand servers (1999)

Article Free Access Share on Optimal and efficient merging schedules for video-on-demand servers Authors: Derek Eager Dept. of Computer Science, University of Saskatchewan Dept. of Computer Science, University of SaskatchewanView Profile , Mary Vernon Computer Sciences Dept., University of Wisconsin Computer Sciences Dept., University of WisconsinSearch about this author , John Zahorjan Dept. of Computer Sci. & Eng., University of Washington Dept. of Computer Sci. & Eng., University of WashingtonView Profile Authors Info & Claims MULTIMEDIA '99: Proceedings of the seventh ACM international conference on Multimedia (Part 1)October 1999Pages 199–202https://doi.org/10.1145/319463.319601Published:30 October 1999Publication History 91citation511DownloadsMetricsTotal Citations91Total Downloads511Last 12 Months34Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease (2001)

Alzheimer's disease is a dementia that involves progressive deposition of amyloid beta-protein (Abeta) in brain regions important for memory and cognition, followed by secondary inflammation that contributes to the neuropathologic process. Immunization with Abeta can reduce cerebral Abeta burden and consequent neuropathologic changes in the brains of mice transgenic for the beta-amyloid precursor protein (APP). We found that transgenic expression of human APP in B6SJL mice, under the prion promoter, results in immune hyporesponsiveness to human Abeta, in terms of both antibody and cellular immune responses. The decreased antibody responses were related not to B cell tolerance but rather to the inability of Abeta-specific T cells to provide help for antibody production. The immune hyporesponsiveness could be overcome if T cell help was provided by coupling an Abeta B cell epitope to BSA. Our results suggest that expression of APP in transgenic mice is associated with an Abeta-specific impaired adaptive immune response that may contribute to the neuropathology. Moreover, humans with life-long elevation of brain and peripheral Abeta (e.g., patients with presenilin mutations or Down syndrome) could have reduced immune responses to Abeta vaccination.
100 pT/cm single-point MEMS magnetic gradiometer from a commercial accelerometer (2020)

Magnetic sensing is present in our everyday interactions with consumer electronics and demonstrates the potential for the measurement of extremely weak biomagnetic fields, such as those of the heart and brain. In this work, we leverage the many benefits of microelectromechanical system (MEMS) devices to fabricate a small, low-power, and inexpensive sensor whose resolution is in the range of biomagnetic fields. At present, biomagnetic fields are measured only by expensive mechanisms such as optical pumping and superconducting quantum interference devices (SQUIDs), suggesting a large opportunity for MEMS technology in this work. The prototype fabrication is achieved by assembling micro-objects, including a permanent micromagnet, onto a postrelease commercial MEMS accelerometer using a pick-and-place technique. With this system, we demonstrate a room-temperature MEMS magnetic gradiometer. In air, the sensor's response is linear, with a resolution of 1.1 nT cm<sup>-1</sup>, spans over 3 decades of dynamic range to 4.6 µT cm<sup>-1</sup>, and is capable of off-resonance measurements at low frequencies. In a 1 mTorr vacuum with 20 dB magnetic shielding, the sensor achieves a 100 pT cm<sup>-1</sup> resolution at resonance. This resolution represents a 30-fold improvement compared with that of MEMS magnetometer technology and a 1000-fold improvement compared with that of MEMS gradiometer technology. The sensor is capable of a small spatial resolution with a magnetic sensing element of 0.25 mm along its sensitive axis, a >4-fold improvement compared with that of MEMS gradiometer technology. The calculated noise floor of this platform is 110 fT cm<sup>-1</sup> Hz<sup>-1/2</sup>, and thus, these devices hold promise for both magnetocardiography (MCG) and magnetoencephalography (MEG) applications.
Upregulation of Fibrinolysis by Adenovirus-Mediated Transfer of Urokinase-Type Plasminogen Activator Genes to Lung Cells in Vitro and in Vivo (1999)

Impaired fibrinolytic activity within the lungs is a common manifestation of acute and chronic inflammatory lung diseases. Our previous work using transgenic mice showed that upregulation of fibrinolysis reduced pulmonary fibrosis following bleomycin-induced inflammatory lung injury. As a strategy to accelerate fibrinolysis, we generated recombinant adenoviruses containing human and mouse urokinase-type plasminogen activator (uPA) cDNAs. Both vectors induced the expression of functional uPA in human lung-derived epithelial A549 cells. A single intratracheal instillation of these uPA-containing adenoviruses into mouse lungs resulted in increased plasminogen activator activity in bronchoalveolar lavage fluid for at least 2 weeks. Plasma-derived fibrin-rich matrices overlaid on A549 cells infected with these uPA vectors were lysed efficiently in a dose-dependent fashion. Similarly, fibrin matrices formed within intact lungs that had been infected with these uPA-containing adenoviruses were also lysed more rapidly compared with noninfected and control virus-infected lungs. These results indicate that adenovirus-mediated transduction of uPA successfully upregulates fibrinolysis in vitro and in vivo. These uPA vectors can be readily used for testing the role of the fibrinolytic system in animal models of lung fibrosis, with particular attention to their therapeutic potential.
Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects (2003)

Site-specific delivery of trophic factors in the brain may be important for achieving therapeutic efficacy without unwanted side effects. This study evaluated the site-specific infusion of glial cell line-derived neurotrophic factor (GDNF) into the right putamen of aged rhesus monkeys. After 4 weeks of continuous infusion at a rate of 22.5 microg/day, GDNF had diffused up to 11 mm from the catheter openings in the putamen into the rostral putamen, internal capsule, external capsule, caudate nucleus, and globus pallidus. Anisotropic flow along the external capsule tracts carried GDNF into the anterior amygdaloid area. Backflow of GDNF along the catheter track from the frontal cortex infiltrated juxtaposed corpus callosal and cortical tissue. GDNF was carried by retrograde transport to dopamine neurons in the ipsilateral substantia nigra, stimulating an 18% increase in the number of tyrosine hydroxylase (TH)-positive dopamine neurons and a 28% increase in dopamine neuron perikaryal size. Also, TH-positive fiber density was increased in the ipsilateral globus pallidus, caudate nucleus, and putamen. Anatomic effects from GDNF stimulation of the dopaminergic system were restricted to the ipsilateral hemisphere. Retrograde GDNF labeling was also present in a few TH-positive neurons in the locus coeruleus and a large cluster of TH-negative neurons in the ventral anterior thalamus. Anterograde transport of GDNF was evident in axons in the pyramidal tract from the cerebral peduncle to the caudal spinal cord. Tissue injury from the intraparenchymal catheter and continuous infusion was confined primarily to a narrow zone surrounding the track and was mild to moderate in severity.
Acid Treatment of Cavities Under Resin Fillings: Bacterial Growth in Dentinal Tubules and Pulpal Reactions (1973)

Prepared cavities were treated with citric acid before restoring them with a composite resin. Subsequently, bacteria were found within dentinal tubules associated with inflammatory reactions within the pulp.
Poder local y sentimiento realista en la independencia de Santa Marta (2025)

Aunque reconocida por la historiografía colombiana como Realista durante el período de la Independencia, tal actitud de la cuidad de Santa Marta no ha sido examinada con mayor detalle. Solo ha sido objeto de juicio “aprisionados” por los acontecimientos de la época o por caracterizaciones carentes de bases explicativas del fenómeno en cuestión.
Male erectile dysfunction assessment and treatment options. (1994)

Until the early 1970s impotence was believed to be primarily a psychological disorder. The treatment usually consisted of empiric testosterone administration and psychotherapy, that were often ineffective. The introduction in the early 1970s of penile implants changed the treatment options and at the same time ushered in the modern era of male sexual medicine. Clinical as well as laboratory research improved significantly the diagnosis and treatment options of the impotent man. Today the man with a sexual problem has a much better chance of proper diagnosis and effective treatment.
A multimodal mixture-of-experts model for dynamic emotion prediction in movies (2016)

This paper addresses the problem of continuous emotion prediction in movies from multimodal cues. The rich emotion content in movies is inherently multimodal, where emotion is evoked through both audio (music, speech) and video modalities. To capture such affective information, we put forth a set of audio and video features that includes several novel features such as, Video Compressibility and Histogram of Facial Area (HFA). We propose a Mixture of Experts (MoE)-based fusion model that dynamically combines information from the audio and video modalities for predicting the emotion evoked in movies. A learning module, based on hard Expectation-Maximization (EM) algorithm, is presented for the MoE model. Experiments on a database of popular movies demonstrate that our MoE-based fusion method outperforms popular fusion strategies (e.g. early and late fusion) in the context of dynamic emotion prediction.
Molecular Recognition of Artificial Single-Electron Acceptor Cosubstrates by Glucose Oxidase? (1996)

International audience
A framework for understanding distributed (deadlock detection) algorithms (1983)

Distributed algorithms tend to be difficult to understand and even more difficult to prove correct. Using distributed dead-lock detection as a running example this paper presents a framework for stating, understanding, and proving the correctness of distributed algorithms for decision problems. The framework consists of a series of complexity levels. To simplify the initial levels, we treat the data structure of the algorithm as a database, and use the database notions of views and transaction atomicity. For each complexity level, we state theorems that need to be proved for each algorithm. The framework is illustrated using several existing deadlock detection algorithms. Finally, it is shown that the framework suggests new algorithms using the best features of several existing algorithms.
Role of Biological Agents in Immune-mediated Inflammatory Diseases (2005)

A new era in the treatment of immune-mediated inflammatory disorders has begun with the clinical availability of anticytokine therapy. Biological agents that are currently available include 3 agents that decrease the activity of tumor necrosis factor-alpha (infliximab, adalimumab, etanercept) and an interleukin-1 receptor antagonist (anakinra), with many more in development. Those extraordinarily effective medications are an important addition to our therapeutic armamentarium, and, although originally developed for rheumatoid arthritis and Crohn disease, have been found to be efficacious in the treatment of seronegative spondyloarthropathies (psoriatic arthritis, ankylosing spondylitis) and juvenile rheumatoid arthritis. Their role is currently being defined in other autoimmune disorders such as uveitis, sarcoidosis, interstitial lung disease, vasculitis, inflammatory myopathies, graft-versus-host disease, and Sjögren syndrome.
Microdeletions involving theSCN1A gene may be common inSCN1A-mutation-negative SMEI patients (2006)

Severe myoclonic epilepsy of infancy (SMEI) or Dravet syndrome is a rare epilepsy syndrome. In 30 to 70% of SMEI patients, truncating and missense mutations in the neuronal voltage-gated sodium-channel alpha-subunit gene (SCN1A) have been identified. The majority of patients have truncating mutations that are predicted to be loss-of-function alleles. Because mutation detection studies use PCR-based sequencing or conformation sensitive gel electrophoresis (CSGE), microdeletions, which are also predicted to be loss-of-function alleles, can easily escape detection. We selected 11 SMEI patients with or without additional features who had no SCN1A mutation detectable with sequencing analysis. In addition, none of the patients was heterozygous for any of the SNPs in SCN1A, indicating that they were either homozygous for all SNPs or hemizygous due to a microdeletion of the gene. We subsequently analyzed these patients for the presence of microdeletions in SCN1A using a quantitative PCR method named multiplex amplicon quantification (MAQ), and observed three patients missing one copy of the SCN1A gene. All three microdeletions were confirmed by fluorescence in situ hybridization (FISH). These findings demonstrate that a substantial percentage of SCN1A-mutation-negative SMEI patients with or without additional features carry a chromosomal microdeletion comprising the SCN1A gene and that haploinsufficiency of the SCN1A gene is a cause of SMEI.
Direct Deoxygenation of the Hydroxy Group of Methyl 1-Hydroxyalkyl-(phenyl)-phosphinates using Diphosphorus Tetraiodide (1985)

The hydroxy group of methyl 1-hydroxyalkyl-(phenyl)-phosphinates 3, prepared from methyl phenylphosphinate 1 and aldehydes or ketones 2, is directly deoxygenated on treatment with diphosphorus tetraiodide to give the methyl alkyl-(phenyl)-phosphinates 4.
Clinical and genetic aspects of hypophosphatasia in Japanese patients (2013)

The most frequent clinical type was the PLH type with prognosis related to respiratory failure, biochemical/radiological changes and ALPL mutations. Cerebral manifestations frequently occurred. Genotype-phenotype correlations were associated with specific outcomes in the PLH type, whereas different clinical features were associated with the same genotype in the non-lethal type.
The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor (1995)

The monoamine histamine is one of the several chemical messengers involved in the concerted regulation of (patho)physiological processes. In rat brain, histamine can be found in a restricted population of neurons originating from the tuberomammillary nucleus of the hypothalamus [1, 2]. These histaminergic neurons project diffusely to several brain areas and are involved in the regulation of physiological functions (e.g. sleep/wakefullness, feeding, cardiovascular control, neuroendocrine control) [1, 2]. In the periphery histamine is mainly found in mast cells, basophils and enterochrommafin cells. Mast cell degranulation after IgG-allergen interactions results in a massive release of histamine, which is responsible for many of the well-known symptoms of allergic conditions [3, 4]. In gastric mucosa histamine is especially stored in enterochromaffin cells, from which it can be release upon stimulation with gastrin or acetylcholine [5]. In turn, histamine stimulates the parietal cell, resulting in gastric acid secretion [5].
Understanding and Managing Cancer Cachexia (2003)

MacDonald, Neil MD, FRCP; Easson, Alexandra M MD, FRCSC, FACS; Mazurak, Vera C PhD; Dunn, Geoffrey P MD, FACS; Baracos, Vickie E PhD Author Information
Clinical utility of low-density lipoprotein particle measurement in management of cardiovascular disease: a case report (2011)

Abstract: Despite adequate screening and low-density lipoprotein cholesterol (LDL-C)-lowering therapy, it has been recognized that many patients with low or moderate LDL-C levels experience cardiovascular events. Furthermore, many patients with cardiovascular disease and relatively normal levels of LDL-C have increased levels of low-density lipoprotein particles (LDL-P). The purpose of this case report is to illustrate the importance of LDL-P in the surprising presentation of vascular disease in a woman who had a high concentration of high-density lipoprotein cholesterol (HDL-C). By utilizing lipoprotein information, patients can be appropriately selected to receive suitable medication, leading to better health outcomes. Keywords: lipoprotein particle concentration, premature coronary artery disease, lipid profile, combination therapy, vitamin D deficiency
Protein structural plasticity exemplified by insertion and deletion mutants in T4 lysozyme (1996)

To further investigate the ways in which proteins respond to changes in the length of the polypeptide chain, a series of 32 insertions and five deletions were made within nine different alpha-helices of T4 lysozyme. In most cases, the inserted amino acid was a single alanine, although in some instances up to four residues, not necessarily alanine, were used. Different insertions destabilized the protein by different amounts, ranging from approximately 1 to 6 kcal/mol. In one case, no protein could be obtained. An "extension" mutant in which the carboxy terminus of the molecule was extended by four alanines increased stability by 0.3 kcal/mol. For the deletions, the loss in stability ranged from approximately 3 to 5 kcal/mol. The structures of six insertion mutants, as well as one deletion mutant and the extension mutant, were determined, three in crystal forms nonisomorphous with wild type. In all cases, including previously described insertion mutants within a single alpha-helix, there appears to be a strong tendency to preserve the helix by translocating residues so that the effects of the insertion are propagated into a bend or loop at one end or the other of the helix. In three mutants, even the hydrophobic core was disrupted so as to permit the preservation of the alpha-helix containing the insertion. Translocation (or "register shift") was also observed for the deletion mutant, in this case a loop at the end of the helix being shortened. In general, when translocation occurs, the reduction in stability is only moderate, averaging 2.5 kcal/mol. Only in the most extreme cases does "bulging" or "looping-out" occur within the body of an alpha-helix, in which case the destabilization is substantial, averaging 4.9 kcal/mol. Looping-out can occur for insertions close to the end of a helix, in which case the destabilization is less severe, averaging 2.6 kcal/mol. Mutant A73-[AAA] as well as mutants R119-[A] and V131-[A], include shifts in the backbone of 3-6 A, extending over 20 residues or more. As a result, residues 114-142, which form a "cap" on the carboxy-terminal domain, undergo substantial reorganizations such that the interface between this "cap" and the rest of the protein is altered substantially. In the case of mutant A73-[AAA], two nearby alpha-helices, which form a bend of approximately 105 degrees in the wild-type structure, reorganize in the mutant structure to form a single, essentially straight helix. These structural responses to mutation demonstrate the plasticity of protein structures and illustrate ways in which their three-dimensional structures might changes during evolution.
On the statistics of block errors in bursty channels (1997)

In the development of encoding algorithms for image, video, and other mixed media transmissions, it is important to note that the channel "seen" by the applications is the physical channel as modified by the error-correcting mechanisms used at the physical level. Therefore, the statistics of the residual error process is relevant to the design of encoding algorithms. In this paper, we study the second- and third-order statistics of the residual error process when block transmissions are performed over a bursty channel. The effect of interleaving is explicitly studied. The conditions under which a Markovian model for the block errors is adequate are identified. Derivations of the parameters of the block error process are then presented in terms of the parameters of the bit/symbol error process. At higher data speeds an effective interleaving strategy is found to require a very large buffer.
Oligomeric benzimidazoles with reactive end groups (1979)

Abstract The condensation of aromatic diamines with aromatic dinitriles and the subsequent conversion of the amidines formed to benzimidazole units has been adapted to the preparation of oligomeric benzimidazoles with nitrile and carboxyl end groups. These are promising new dibasic acids for the preparation of heat‐stable condensation polymers.