gebhart/patrepeval huggingface dataset:
Electrical Disintegration of Rock (1995)

Abstract Mechanical compressive and impactive disintegration of rock by metallic devices or by water shock waves consumes a disproportionally high amount of energy and are of low efficiency for liberating mineral aggregates in ores. The tensile loading of the rock, which results in significant saving of energy and decreases the cost of maintenance of equipment and substantially improves the mineral liberation, cannot be achieved in mechanical crushers. Electrical disintegration by high voltage pulses results from the tensile failure of rock and can be carried out in inexpensive light weight non-metallic containers. The plasma explosion, generated by pulses inside the rock fragments, is induced by development of the treelike conductive capillaries which result from application of an electrical field which exceeds the dielectric strength of the rock. The explosion takes place on return of the streamers bridging the two electrodes. Tests on continuous comminution of complex apatite-nepheline ore, gold bearing quartzites, emerald bearing pegmatites, diamond bearing kimberlites and other ores show high liberation results from the electrical disintegration technique. Efficiency of electrical disintegration depends on the right match of voltage and energy of pulses with mechanical strength of rock and desirable size of fragments, and is directly proportional to the rate of build up of voltage across the rock. Electrical disintegration of rock consumes substantially less energy than compressive mechanical crushing and enhances effect of liberation of mineral constituents of rock aggregates.
Iterative soft sequential estimation assisted acquisition of m -sequences (2002)

A novel iterative soft sequential-estimation (ISSE) method is proposed for the acquisition of m-sequences. The ISSE algorithm is designed based on the principle of iterative soft-in-soft-out (SISO) decoding. The employment of the proposed ISSE acquisition scheme is particularly beneficial for the acquisition of long m-sequences. Results demonstrate that a chip signal-to-noise ratio reduction of ∼10 dB is achievable at an erroneous acquisition probability of 10−4.
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2 (1994)

The fusion (F) protein of human parainfluenza virus type 3 contains the tribasic cleavage site R-T-K-R, which was altered by site-directed mutagenesis. Wild-type F protein and various mutants were expressed by recombinant vaccinia viruses. The endogenous endoprotease present in CV-1 cells cleaves F variants containing the furin recognition motif R-X-K/R-R but not variants containing the dibasic site K-R or a single R at the cleavage site. A similar cleavage pattern was obtained when the subtilisin-like endoproteases Kex2 and furin were coexpressed with the wild type and mutants of the F protein. Peptidylchloromethylketone inhibitors mimicking basic cleavage sites prevent cleavage of the precursor Fo by the endogenous protease only when the furin-specific motif is present in the peptidyl portion. The data support the concept that furin is a cellular protease responsible for the activation of the F protein of human parainfluenza virus type 3.
Consistency rationing in the cloud (2009)

Cloud storage solutions promise high scalability and low cost. Existing solutions, however, differ in the degree of consistency they provide. Our experience using such systems indicates that there is a non-trivial trade-off between cost, consistency and availability. High consistency implies high cost per transaction and, in some situations, reduced availability. Low consistency is cheaper but it might result in higher operational cost because of, e.g., overselling of products in a Web shop. In this paper, we present a new transaction paradigm, that not only allows designers to define the consistency guarantees on the data instead at the transaction level, but also allows to automatically switch consistency guarantees at runtime. We present a number of techniques that let the system dynamically adapt the consistency level by monitoring the data and/or gathering temporal statistics of the data. We demonstrate the feasibility and potential of the ideas through extensive experiments on a first prototype implemented on Amazon's S3 and running the TPC-W benchmark. Our experiments indicate that the adaptive strategies presented in the paper result in a significant reduction in response time and costs including the cost penalties of inconsistencies.
Completely positive dynamical semigroups of N-level systems (1976)

We establish the general form of the generator of a completely positive dynamical semigroup of an N-level quantum system, and we apply the result to derive explicit inequalities among the physical parameters characterizing the Markovian evolution of a 2-level system.
Growth, structural and optical properties of AlGaN nanowires in the whole composition range (2013)

We report on the growth of AlxGa1-xN nanowires by plasma-assisted molecular beam epitaxy for x in the 0.3-0.8 range. Based on a combination of macro- and micro-photoluminescence, Raman spectroscopy, x-ray diffraction and scanning electron microscopy experiments, it is shown that the structural and optical properties of AlGaN NWs are governed by the presence of compositional fluctuations associated with strongly localized electronic states. A growth model is proposed, which suggests that, depending on growth temperature and metal adatom density, macroscopic composition fluctuations are mostly of kinetic origin and are directly related to the nucleation of the AlGaN nanowire section on top of the GaN nanowire base which is used as a substrate.
Crossover comparison of IPX066 and a standard levodopa formulation in advanced Parkinson's disease (2011)

The objective of the study was to compare the pharmacokinetics, motor effects, and safety of IPX066, a novel extended-release formulation of carbidopa-levodopa, with an immediate-release carbidopa-levodopa formulation in advanced Parkinson's disease. We performed an open-label crossover study in 27 subjects with advanced Parkinson's disease experiencing motor fluctuations on levodopa therapy. Subjects were randomized 1:1 to 8 days' treatment with either immediate-release carbidopa-levodopa followed by IPX066 or IPX066 followed by immediate-release carbidopa-levodopa. Pharmacokinetic and motor assessments were undertaken on day 1 for 8 hours (following a single dose) and on day 8 for 12 hours (during multiple-dose administration). Following a single dose of IPX066 or immediate-release carbidopa-levodopa, plasma levodopa concentrations increased at a similarly rapid rate and were sustained above 50% of peak concentration for 4 hours with IPX066 versus 1.4 hours with immediate-release carbidopa-levodopa (P < .0001). Multiple-dose data showed IPX066 substantially reduced variability in plasma levodopa concentrations despite a lower dosing frequency (mean, 3.5 vs 5.4 administrations per day). In addition, total levodopa exposure during IPX066 treatment was approximately 87% higher, whereas the increase in levodopa C(max) was approximately 30% compared with immediate-release carbidopa-levodopa. Both products were well tolerated. IPX066 provided more sustained plasma levodopa concentrations than immediate-release carbidopa-levodopa. Larger, longer-term, well-controlled studies should be conducted to provide rigorous assessment of the clinical effects of IPX066.
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals (2008)

Research on basic cellular processes involving local production or delivery of proteins, such as activity-dependent synaptic modification in neurons, would benefit greatly from a robust, nontoxic method to visualize selectively newly synthesized copies of proteins of interest within cells, tissues, or animals. We report a technique for covalent labeling of newly synthesized proteins of interest based on drug-dependent preservation of epitope tags. Epitope tags are removed from proteins of interest immediately after translation by the activity of a sequence-specific protease until the time a protease inhibitor is added, after which newly synthesized protein copies retain their tags. This method, which we call TimeSTAMP for time-specific tagging for the age measurement of proteins, allows sensitive and nonperturbative visualization and quantification of newly synthesized proteins of interest with exceptionally tight temporal control. We demonstrate applications of TimeSTAMP in retrospectively identifying growing synapses in cultured neurons and in visualizing the distribution of recently synthesized proteins in intact fly brains.
Density of Demodex folliculorum in Perioral Dermatitis (2005)

The role of Demodex folliculorum in perioral dermatitis is not satisfactory explained. Our purpose was to assess the density of D. folliculorum in perioral dermatitis and evaluate the relationship of the mite count to previous therapy with topical steroids. A standardized skin surface biopsy of the chin was performed in 82 female patients with perioral dermatitis and in 70 control female subjects. Patients who received previous topical steroid therapy had a significantly higher mite density than the patients who had received no topical steroids (p<0.001). In the latter group of patients, the mite density did not differ significantly from that of the control group (p=0.629). Mite density increased significantly with the length of treatment with topical steroids (p<0.001). Our results suggest that increased density of D. folliculorum in perioral dermatitis is a secondary phenomenon, associated with topical steroid therapy.
Improvement of Doxorubicin Efficacy Using Liposomal Anti-Polo-like Kinase 1 siRNA in Human Renal Cell Carcinomas (2014)

It is well-known that renal cell carcinomas (RCCs) are resistant to classical cytotoxic anticancer drugs. Therefore, facilitating the impact of anticancer drugs by altering the cell phenotype should be a useful strategy for circumventing this. We developed a multifunctional envelope-type nanodevice (MEND) as an in vivo carrier of siRNA to tumor tissues. We previously reported that a MEND containing YSK05 (YSK-MEND) efficiently delivered siRNA in RCC-bearing mice. We herein report on a combination therapy involving the use of siRNA-mediated specific gene knockdown and cytotoxic drug doxorubicin (DOX), and an advantage of YSK-MEND as an investigation tool for in vivo function of a gene. si-PLK1 encapsulated within YSK-MEND was prepared using the tertiary butanol dilution method. The in vitro cellular viability under the exposure of DOX was compared between OS-RC-2 cells with and without si-PLK1 transfection. In an in vivo study, tumor-bearing mice were systemically injected with YSK-MEND and DOX-loaded liposomes. The combination of DOX and si-PLK1 drastically reduced tumor growth rate, and apoptotic cells were observed. In an in vitro study, PLK1 knockdown increased G2/M cell population and reduced the expression of cyclin B1 (CCNB1) mRNA. CCNB1 suppression by si-PLK1 encapsulated in YSK-MEND was also observed in the in vivo experiments. A combination of DOX and anti-polo-like kinase 1 siRNA (si-PLK1) resulted in a measurable delay in OS-RC-2 tumor growth. This result suggests that the combination of si-PLK1 delivery and doxorubicin by YSK-MEND holds potential for RCC therapy via cell CCNB1 regulation.
Mass Transport in Arteries and the Localization of Atherosclerosis (2003)

Atherosclerosis is a disease of the large arteries that involves a characteristic accumulation of high-molecular-weight lipoprotein in the arterial wall. This review focuses on the mass transport processes that mediate the focal accumulation of lipid in arteries and places particular emphasis on the role of fluid mechanical forces in modulating mass transport phenomena. In the final analysis, four mass transport mechanisms emerge that may be important in the localization of atherosclerosis: blood phase controlled hypoxia, leaky endothelial junctions, transient intercellular junction remodeling, and convective clearance of the subendothelial intima and media. Further study of these mechanisms may contribute to the development of therapeutic strategies for atherosclerotic diseases.
Anti-mitochondrial antibodies and other immunological tests in primary biliary cirrhosis (1999)

Primary biliary cirrhosis (PBC) has been classified as an autoimmune disease. It is characterized by a multitude of immune-mediated symptoms and phenomena. Humoral autoimmunity directed against mitochondrial auto-antigens or structures cross-reactive with these proteins represents the basis of one of the most specific tests in any autoimmune disease: the detection of auto-antibodies against pyruvate dehydrogenase. The molecular cloning and expression of antigens of the ketoacid dehydrogenase complex has led to the establishment of highly specific and reliable testing systems for anti-mitochondrial antibodies (AMA). The characterization of specific antinuclear auto-antibodies has contributed to the diagnosis of AMA-negative PBC and is an important marker in overlap syndromes of PBC and other autoimmune liver diseases.
The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p (1990)

Abstract The full-length coding sequence of the human erythropoietin receptor has been assembled from cDNA and genomic DNA. The derived 508 amino acid sequence is 82% identical to the murine erythropoietin (Epo) receptor with one single residue gap in alignment. There is no major structural difference between the human and murine receptor molecules. Nucleotide sequence homology is, as expected, very high within the coding domain. Unexpectedly, there are two distinct, short stretches of 3′ untranslated sequence homology between human and murine cDNAs. The functional significance of this sequence conservation is unknown. The human Epo receptor gene is localized to human chromosome 19p by in situ hybridization. This chromosome assignment is confirmed by hybridization to a panel of sorted human chromosomes.
Sorption behavior of plutonium(IV) onto soils in the presence of humic acid (2002)

Influence of humic acid on the sorption of 238Pu onto geologic media using a coastal sand, which does not sorb humic acid, and an ando soil, which sorbs humic acid very well, was examined with respect to molecular sizes of humic acid. Apparent sorption affinity of 238Pu for the coastal sand decreased with increasing humic acid concentration. As to the ando soil, the sorption affinity of 238Pu became largest in the presence of several mg/dm3 of humic acid. The humic acid fraction smaller than 100,000 daltons relates to the complexation with 238Pu and the sorption onto the soils, particularly the humic acid fraction of 30,000-100,000 daltons was dominant. Most 238Pu formed humic compounds even in a low humic acid concentration region; resulting plutonium humates are considered to control the apparent sorption affinity of ~38Pu. It is concluded from above results that a specific molecular size of humic acid controls the complexation ability and the apparent sorption affinity of 238Pu.
Face detection in color images (2002)

Human face detection is often the first step in applications such as video surveillance, human computer interface, face recognition, and image database management. We propose a face detection algorithm for color images in the presence of varying lighting conditions as well as complex backgrounds. Our method detects skin regions over the entire image, and then generates face candidates based on the spatial arrangement of these skin patches. The algorithm constructs eye, mouth, and boundary maps for verifying each face candidate. Experimental results demonstrate successful detection over a wide variety of facial variations in color, position, scale, rotation, pose, and expression from several photo collections.
Are Increasing 5-Year Survival Rates Evidence of Success Against Cancer? (2000)

Although 5-year survival is a valid measure for comparing cancer therapies in a randomized trial, our analysis shows that changes in 5-year survival over time bear little relationship to changes in cancer mortality. Instead, they appear primarily related to changing patterns of diagnosis. JAMA. 2000.
3D domain swapping: As domains continue to swap (2002)

Three-dimensional (3D) domain swapping creates a bond between two or more protein molecules as they exchange their identical domains. Since the term '3D domain swapping' was first used to describe the dimeric structure of diphtheria toxin, the database of domain-swapped proteins has greatly expanded. Analyses of the now about 40 structurally characterized cases of domain-swapped proteins reveal that most swapped domains are at either the N or C terminus and that the swapped domains are diverse in their primary and secondary structures. In addition to tabulating domain-swapped proteins, we describe in detail several examples of 3D domain swapping which show the swapping of more than one domain in a protein, the structural evidence for 3D domain swapping in amyloid proteins, and the flexibility of hinge loops. We also discuss the physiological relevance of 3D domain swapping and a possible mechanism for 3D domain swapping. The present state of knowledge leads us to suggest that 3D domain swapping can occur under appropriate conditions in any protein with an unconstrained terminus. As domains continue to swap, this review attempts not only a summary of the known domain-swapped proteins, but also a framework for understanding future findings of 3D domain swapping.
A new approach to fuzzy modeling (1997)

This paper proposes a new approach to fuzzy modeling. The suggested fuzzy model can express a given unknown system with a few fuzzy rules as well as Takagi and Sugeno's model (1985), because it has the same structure as that of Takagi and Sugeno's model. It is also as easy to implement as Sugeno and Yasukawa's model (1993) because its identification mimics the simple identification procedure of Sugeno and Yasukawa's model. The suggested algorithm is composed of two steps: coarse tuning and fine tuning. In coarse tuning, fuzzy C-regression model (FCRM) clustering is used, which is a modified version of fuzzy C-means (FCM). In fine tuning, gradient descent algorithm is used to precisely adjust parameters of the fuzzy model instead of nonlinear optimization methods used in other models. Finally, some examples are given to demonstrate the validity of this algorithm.
Directed Assembly of Cylinder-Forming Block Copolymer Films and Thermochemically Induced Cylinder to Sphere Transition:  A Hierarchical Route to Linear Arrays of Nanodots (2005)

A morphological transition from cylinders to spheres was induced in an asymmetric diblock copolymer, poly(styrene)-block-poly(tert-butyl acrylate) (PS-b-PtBA). The periodic arrays of the poly(tert-butyl acrylate) (PtBA) domains were transformed to the ordered poly(acrylic anhydride) (PAA) spheres via the thermal deprotection of tert-butyl acrylate linkages and the subsequent volume change of the minority block. Coupled with techniques to direct the assembly of cylinder-forming block copolymers, this finding provides new routes to fabricate ordered geometries of nanodot arrays.
Warm Hepatic Ischemia in Pigs: Effects of L-Arginine and Oligotide Treatment (2001)

Reperfusion injury represents a key event leading to graft nonfunction. Maintaining adequate nitric oxide levels and stimulating vasodilator synthesis can probably minimize endothelial damage. The aim of this study was to investigate the effect of L-arginine, a substrate of nitric oxide synthesis, and oligotide, a promoter of prostacyclin synthesis, on liver function and morphology after warm ischemia-reperfusion injury. After constructing a side-to-side portacaval shunt, ischemia was induced by clamping the hepatic hilum for 2 h above the shunt, in 19 female pigs divided into a control group (n = 7), an L-arginine treatment group (n = 6), and an oligotide treatment group (n = 6). Liver function tests and measurements of serum and red blood cell malondialdehyde and plasma nitric oxide levels were performed before reperfusion and at 1, 10, 60, and 120 min after reperfusion. Liver biopsies, taken before reperfusion and at 30 min and 7 days after reperfusion, were analyzed for tissue malondialdehyde, histological-ultrastructural features, and apoptosis evaluation. Thirty minutes after reperfusion, liver malondialdehyde, sinusoidal congestion, necrosis, and apoptosis were significantly lower in the L-arginine group than in the controls (p < .05). On postoperative day 7, tissue malondialdehyde decreased, while plasma nitric oxide and hepatocyte glycogen content were increased in the L-arginine group compared to controls (p < .05). This study demonstrates the protective effect of L-arginine on hepatic lipoperoxidation and liver morphology in a pig model of warm ischemia-reperfusion injury. The increased plasma levels of nitric oxide a week after ischemia-reperfusion injury support the hypothesis that it has a role in preventing liver damage. The same beneficial effect was not confirmed for oligotide.
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure (2017)

The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-activity relationships and were able to decrease oxidative metabolism significantly. These studies resulting in the discovery of once daily sGC stimulator vericiguat (compound 24, BAY 1021189), currently in phase 3 trials for chronic heart failure, are now reported.
Plasma exchange for severe attacks of CNS demyelination: Predictors of response (2002)

The authors reviewed 59 consecutive patients treated with plasma exchange (PE) for acute, severe attacks of CNS demyelination at Mayo Clinic from January 1984 through June 2000. Most patients had relapsing-remitting MS (n = 22, 37.3%), neuromyelitis optica (NMO) (n = 10, 16.9%), and acute disseminated encephalomyelitis (n = 10, 16.9%). PE was followed by moderate or marked functional improvement in 44.1% of treated patients. Male sex (p = 0.021), preserved reflexes (p = 0.019), and early initiation of treatment (p = 0.009) were associated with moderate or marked improvement. Successfully treated patients improved rapidly following PE, and improvement was sustained.
An Image Analysis System for the Determination of Tooth Dimensions from Study Casts: Comparison with Manual Measurements of Mesio-distal Diameter (1986)

A first comparison of an image analysis method with classical hand measurement was made using the mesio-distal diameter data derived by the simplest image analysis method, the jawview mode. Fifty casts of male Hong Kong Chinese dental students, mean age 20.4 years, were examined by both methods. The two techniques gave comparable overall results, the correlation coefficients generally being greater than 0.9. A combination of the buccal and occlusal image analysis views gave the best correlation with hand measurement with a comparable variability for different tooth types. For certain teeth, particularly posteriors, reproducibility was better using hand measurement. Optimal weighting of the data from these two different image analysis views can give an "estimated hand measurement" value. Further development of the method to deal with differing orientations of teeth is possible.