gebhart/patrepeval huggingface dataset:
A Single-Chip Full-Duplex High Speed Transceiver for Multi-Site Stimulating and Recording Neural Implants (2015)

We present a novel, fully-integrated, low-power full-duplex transceiver (FDT) to support high-density and bidirectional neural interfacing applications (high-channel count stimulating and recording) with asymmetric data rates: higher rates are required for recording (uplink signals) than stimulation (downlink signals). The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size and complexity. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2.4-GHz on-off keying (OOK) receiver. Proper isolation (>20 dB) between the TX and RX path is implemented 1) by shaping the transmitted pulses to fall within the unregulated UWB spectrum (3.1-7 GHz), and 2) by space-efficient filtering (avoiding a circulator or diplexer) of the downlink OOK spectrum in the RX low-noise amplifier. The UWB 3.1-7 GHz transmitter can use either OOK or binary phase shift keying (BPSK) modulation schemes. The proposed FDT provides dual band 500-Mbps TX uplink data rate and 100 Mbps RX downlink data rate, and it is fully integrated into standard TSMC 0.18- μm CMOS within a total size of 0.8 mm(2). The total measured power consumption is 10.4 mW in full duplex mode (5 mW at 100 Mbps for RX, and 5.4 mW at 500 Mbps or 10.8 pJ/bit for TX). Additionally, a 3-coil inductive link along with on-chip power management circuits allows to powering up the implantable transceiver wirelessly by delivering 25 mW extracted from a 13.56-MHz carrier signal, at a total efficiency of 41.6%.
Dacarbazine (DTIC) plus bevacizumab (B) combination therapy in chemotherapy (CTh)-naïve advanced melanoma (MM) patients (pts): A phase II study. (2010)

8536 Background: Advanced MM pts' poor prognosis is not improved by the neither of the 2 FDA approved agents, DTIC and IL-2 (median survival-time < 9 month [mo]; 5-yr survival-rate < 5%). Single-agent DTIC has average response-rate of 10% and median response-duration of 5-6 mo, being poly-CTh never proven to be superior. To improve such sober results, different DTIC- combinations have been proposed. MM in vitro models showed VEGF transcription up-regulation by DTIC, suggesting DTIC/anti-VEGF combination as an intriguing exploiting path. Methods: Between July 2006-September 2009, at IEO, Milan, 40 CTh-naïve advanced MM pts underwent CTh with DTIC (800 mg/mq q4w) + B (10 mg/kg q2w), being disease evaluated at each access by physical examination and every 3 cycles by whole-body (wb) CT-scan, according to RECIST criteria. Response rate, median TTP and safety were analyzed. Results: 36/40 pts were evaluated at the analysis-time, with 4 screening failures (3 pts: brain metastasis detection at the pre-study wb CT-scan; 1pts: bleeding risk). Male/Female = 23/13; median age was 57 yr. PS 0/1 = 32/4. 6 pts (16.6%) developed partial response (PR), 13 (36.1%) stable disease (SD ≥ 24w = 10 pts, 25.6%); 17 (47.2%) progressive disease (PD; 8 pts: RECIST-criteria PD at the first CT-scan evaluation; 9 pts: early clinical PD). PR pts were on average older (65.7 yrs; range 46.3-74.1) than both SD (57.2 yrs; range 33.1-78.5) and PD pts (51.4 yrs; range 31.6-76.3). Median TTP was 6 mo (95% CI 2.8-12.6). Furthermore, exploratory data analysis interestingly shows 42.2% clinical benefit (defined as PR+SD ≥ 24w) and 16.5 mo (95% CI 5-31.5) median survival. Treatment was well tolerated (mild hypertension and mucositis [8/36], easily controlled by symptomatics); 3 SAEs were recorded: 2 major cardiac events and 1 allergic reaction to B at the first administration. Conclusions: Long-lasting response obtained in both SD and PR pts and mild side effects support DTIC/B as a promising combination in advanced MM pts. We are currently investigating whether the molecular pattern and gene profiling of each patient can predict responders vs. nonresponders to the DTIC/B combination. No significant financial relationships to disclose.
Linear-Time Approximation for Maximum Weight Matching (2014)

The maximum cardinality and maximum weight matching problems can be solved in Õ ( m √ n ) time, a bound that has resisted improvement despite decades of research. (Here m and n are the number of edges and vertices.) In this article, we demonstrate that this “ m √ n barrier” can be bypassed by approximation. For any ε &gt; 0, we give an algorithm that computes a (1 − ε )-approximate maximum weight matching in O ( mε −1 log ε −1 ) time, that is, optimal linear time for any fixed ε . Our algorithm is dramatically simpler than the best exact maximum weight matching algorithms on general graphs and should be appealing in all applications that can tolerate a negligible relative error.
Transforming growth factor-beta activation in irradiated murine mammary gland. (1994)

The biological activity of TGF-beta, an important modulator of cell proliferation and extracellular matrix formation, is governed by dissociation of mature TGF-beta from an inactive, latent TGF-beta complex in a process that is critical to its role in vivo. So far, it has not been possible to monitor activation in vivo since conventional immunohistochemical detection does not accurately discriminate latent versus active TGF-beta, nor have events associated with activation been defined well enough to serve as in situ markers of this process. We describe here a modified immunodetection method using differential antibody staining that allows the specific detection of active versus latent TGF-beta. Under these conditions, we report that an antibody raised to latency-associated peptide detects latent TGF-beta, and we demonstrate that LC(1-30) antibodies specifically recognize active TGF-beta 1 in tumor xenografts overproducing active TGF-beta 1, without cross-reactivity in tumors expressing similar levels of latent TGF-beta 1. We previously reported that TGF-beta immunoreactivity increases in murine mammary gland after whole-body 60Co-gamma radiation exposure. Using differential antibody staining we now show that radiation exposure specifically generates active TGF-beta 1. While latent TGF-beta 1 was widely distributed in unirradiated tissue, active TGF-beta 1 distribution was restricted. Active TGF-beta 1 increased significantly within 1 h of irradiation concomitant with decreased latent TGF-beta immunoreactivity. This rapid shift in immunoreactivity provides the first evidence for activation of TGF-beta in situ. This reciprocal pattern of expression persisted for 3 d and was accompanied by decreased recovery of latent TGF-beta 1 from irradiated tissue. Radiation-induced activation of TGF-beta may have profound implications for understanding tissue effects caused by radiation therapy.
The Distribution of Melatonin Binding Sites in Neuroendocrine Tissues of the Ewe1 (1990)

Specific high-affinity binding of 2-[125I]iodomelatonin (IMEL) was examined in 20-micrometer sections prepared from intact Suffolk ewes killed during late anestrus or the breeding season. The pars tuberalis contained by far the highest concentration of IMEL binding sites of all areas studied. Within the telencephalon, intense labeling was found in the mediolateral septum, the ventrolateral septal and septohypothalamic nuclei, the entorhinal cortex, the subiculum, and the inner and outer molecular layers of the hippocampus adjacent to the dentate gyrus. Melatonin binding in the medial preoptic nucleus, bed nucleus of the stria terminalis, and medial preoptic area was less striking but still distinct. Among diencephalic regions, melatonin binding sites existed in low concentrations in the anterior hypothalamus, the tuberal medial basal hypothalamus, and the paraventricular thalamic and supramammillary nuclei. Little binding was evident in the suprachiasmatic or ventromedial nuclei. In the midbrain, significant binding was restricted to the ventral raphe complex and the inferior colliculus. Little specific binding was found in the pars distalis or the pineal gland. The distribution of melatonin binding in the sheep brain is discussed in the context of the influence of this pineal hormone upon seasonal changes in neuroendocrine function.
SACRAL NERVE STIMULATION FOR TREATMENT OF REFRACTORY URINARY URGE INCONTINENCE (1999)

Sacral nerve stimulation is safe and effective in treating refractory urinary urge incontinence.
Optical properties of phosphorus-doped polycrystalline silicon layers (1981)

The index of refraction and the absorption coefficient of low-pressure chemical vapor deposited polycrystalline silicon (poly Si) implanted with various doses of phosphorus were obtained by means of transmittance and reflectance measurements. The refractive index of poly Si is relatively insensitive to doping in the visible region of the spectrum and agrees quite well with published values for single-crystal Si. The absorption coefficient of these films decreases with doping in the visible. Nevertheless, the absorption coefficient corresponding to the highest-doped film (N≊3×1020/cm3) is almost twice the published values for lightly doped single-crystal Si. In the infrared, the index of refraction decreases systematically and the absorption coefficient increases systematically with doping. This dependence of the optical parameters on doping is attributed to the presence of free carriers. A free-carrier dispersion/absorption model is applied to the measured refractive index in the region 1.2–1.8 μm and to the reflectance measurements in the region 2.5–7.5 μm. The model gives carrier concentrations for the two types of measurements which differ by 50%. Possible explanations for this difference are discussed. The carrier concentrations and mobilities obtained from optical and Hall-effect measurements are compared.
Localisation using LiDAR and Camera (2017)

Localisation of the vehicle is one of the most important part of autonomous driving and can be achieved in many different ways.Most autonomous vehicles today are not able to navigate in complex environments, for instance snow covered roads or heavy rain.This thesis proposes a method for localising a vehicle using LiDAR and Camera fused together with INS and GNSS.The method is intended to work in the complex environments mentioned earlier.The system consists of a vehicle equipped with a 3D scanning LiDAR, a forward looking camera, a combined INS/GNSS unit and a 3D map over the area of interest.The LiDAR and camera are used together to measure distances to points of interest in the 3D map which are then used to triangulate the position of the vehicle.The position from the triangulation is then fused with INS and GNSS in an Ensemble Kalman Filter along with a motion model of the vehicle to estimate the position of the vehicle.It is concluded that the system is promising with a mean translational error of about 40 centimeters which is a good result considering that DGPS has about the same accuracy.
A Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis (2011)

Despite compelling epidemiological evidence that folic acid supplements reduce the frequency of neural tube defects (NTDs) in newborns, common variant association studies with folate metabolism genes have failed to explain the majority of NTD risk. The contribution of rare alleles as well as genetic interactions within the folate pathway have not been extensively studied in the context of NTDs. Thus, we sequenced the exons in 31 folate-related genes in a 480-member NTD case-control population to identify the full spectrum of allelic variation and determine whether rare alleles or obvious genetic interactions within this pathway affect NTD risk. We constructed a pathway model, predetermined independent of the data, which grouped genes into coherent sets reflecting the distinct metabolic compartments in the folate/one-carbon pathway (purine synthesis, pyrimidine synthesis, and homocysteine recycling to methionine). By integrating multiple variants based on these groupings, we uncovered two provocative, complex genetic risk signatures. Interestingly, these signatures differed by race/ethnicity: a Hispanic risk profile pointed to alterations in purine biosynthesis, whereas that in non-Hispanic whites implicated homocysteine metabolism. In contrast, parallel analyses that focused on individual alleles, or individual genes, as the units by which to assign risk revealed no compelling associations. These results suggest that the ability to layer pathway relationships onto clinical variant data can be uniquely informative for identifying genetic risk as well as for generating mechanistic hypotheses. Furthermore, the identification of ethnic-specific risk signatures for spina bifida resonated with epidemiological data suggesting that the underlying pathogenesis may differ between Hispanic and non-Hispanic groups.
Pregabalin for Treatment of Generalized Anxiety Disorder (2005)

Background: Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the ␣ 2 -␦ subunit protein of widely distributed voltagedependent calcium channels in the brain and spinal cord.Objective: To assess the anxiolytic efficacy of pregabalin in patients with generalized anxiety disorder.Design: Double-blind, placebo-controlled, activecomparator trial.Patients were randomized to 4 weeks of treatment with pregabalin, 300 mg/d (n=91), 450 mg/d (n = 90), or 600 mg/d (n = 89); alprazolam, 1.5 mg/d (n=93); or placebo (n = 91).Setting: Psychiatry research and clinic settings.Patients: Outpatients meeting the DSM-IV criteria for generalized anxiety disorder, with a baseline Hamilton Anxiety Rating Scale (HAM-A) total score of 20 or greater.Main Outcome Measures: Change from baseline to end point in total HAM-A score in the pregabalin and alprazolam groups compared with the placebo group.The end point response criterion was 50% or greater reduction in the HAM-A total score.Results: Pregabalin and alprazolam produced a significantly greater reduction in mean±SE HAM-A total score at last-observation-carried-forward end point compared with placebo (-8.4±0.8):pregabalin, 300 mg (-12.2±0.8,PϽ.001), 450 mg (-11.0±0.8,P =.02), and 600 mg (-11.8±0.8,P=.002), and alprazolam (-10.9±0.8,P=.02).By week 1 and at last-observation-carried-forward end point, the 3 pregabalin groups and the alprazolam group had significantly (PϽ.01) improved HAM-A psychic anxiety symptoms compared with the placebo group.Compared with the placebo group, HAM-A somatic anxiety symptoms were also significantly (PϽ.02) improved by the 300-and 600mg pregabalin groups, but not by the 450-mg pregabalin (week 1, P=.06; week 4, P=.32) and the alprazolam groups (week 1, P=.21; week 4, P=.15).Of the 5 treatment groups, the 300-mg pregabalin group was the only medication group that differed statistically in global improvement at treatment end point not only from the placebo group but also from the alprazolam group. Conclusion:Pregabalin was significantly more efficacious than placebo for the treatment of psychic and somatic symptoms of generalized anxiety disorder and was well tolerated by most study patients.
Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women (1997)

The effect of 12-month dehydroepiandrosterone (DHEA) replacement therapy has been evaluated in 14 60- to 70-yr-old women who received daily applications of a 10% DHEA cream. Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an intermediate vaginal maturation index before therapy. The estrogenic effect of DHEA observed in the vagina was not observed in the endometrium, which remained atrophic in all women. Most interesting, the bone mineral density significantly increased at the hip from 0.744 +/- 0.021 to 0.759 +/- 0.025 g/cm2 after 12 months of treatment (P < 0.05). These changes in bone mineral density were associated with a significant 20.0% decrease (P < 0.01) in plasma bone alkaline phosphatase and a 28% decrease in the urinary hydroxyproline/creatinine ratio. A 2.1-fold increase over the control value (P < 0.01) in plasma osteocalcin was concomitantly observed. The present data describe for the first time a series of medically important beneficial effects of DHEA therapy in postmenopausal women through transformation of the precursor steroid DHEA into androgens and/or estrogens in specific peripheral intracrine tissues without significant adverse effects. The stimulatory effect on the vaginal epithelium in the absence of stimulation of the endometrium is of particular interest because it eliminates the need for progestin replacement therapy. On the other hand, the stimulatory effect on bone mineral density accompanied by an increase in serum osteocalcin, a marker of bone formation, suggests stimulation of bone formation by the androgenic action of DHEA, a finding of particular interest for both the prevention and treatment of osteoporosis.
Cluster Ion Implantation in Graphite and Diamond: Radiation Damage and Stopping of Cluster Constituents (2014)

Cluster ion beam technique is a versatile tool which can be used for controllable formation of nanosize objects as well as modification and processing of surfaces and shallow layers on an atomic scale. The current paper present an overview and analysis of data obtained on a few sets of graphite and diamond samples implanted by keV-energy size-selected cobalt and argon clusters. One of the emphases is put on pinning of metal clusters on graphite with a possibility of following selective etching of graphene layers. The other topic of concern is related to the development of scaling law for cluster implantation. Implantation of cobalt and argon clusters into two different allotropic forms of carbon, namely, graphite and diamond is analysed and compared in order to approach universal theory of cluster stopping in matter.
Subspace Identification and Classification of Healthy Human Gait (2013)

A combination of PCA, SVM and ICA is best suited to extract all parts of the gait pattern that discriminates between the two movements and to find a discriminant for the classification of dichotomous kinematic data.
Facile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl)ethoxyacetylene (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl)ethoxyacetyleneYasuyuki Kita, Shuji Akai, Naomi Ajimura, Mayumi Yoshigi, Teruhisa Tsugoshi, Hitoshi Yasuda, and Yasumitsu TamuraCite this: J. Org. Chem. 1986, 51, 22, 4150–4158Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/jo00372a010https://doi.org/10.1021/jo00372a010research-articleACS PublicationsRequest reuse permissionsArticle Views2887Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Constrained random walks on random graphs (2002)

We consider a routing problem in the context of large scale networks with uncontrolled dynamics. A case of uncontrolled dynamics that has been studied extensively is that of mobile nodes, as this is typically the case in cellular and mobile ad-hoc networks. In this paper however we study routing in the presence of a different type of dynamics: nodes do not move, but instead switch between active and inactive states at random times. Our interest in this case is motivated by the behavior of sensor nodes powered by renewable sources, such as solar cells or ambient vibrations. In this paper we formalize the corresponding routing problem as a problem of constructing suitably constrained random walks on random dynamic graphs. We argue that these random walks should be designed so that their resulting invariant distribution achieves a certain load balancing property, and we give simple distributed algorithms to compute the local parameters for the random walks that achieve the sought behavior. A truly novel feature of our formulation is that the algorithms we obtain are able to route messages along all possible routes between a source and a destination node, without performing explicit route discovery/repair computations, and without maintaining explicit state information about available routes at the nodes. To the best of our knowledge, these are the first algorithms that achieve true multipath routing (in a statistical sense), at the complexity of simple stateless operations.
Studies of structure-activity relationships of human interleukin-2. (1986)

Human interleukin-2 (IL-2) has 3 cysteine residues; cysteines 58 and 105 form an intramolecular disulfide bridge, whereas cysteine 125 has a free sulfhydryl group. In this study, site-specific mutagenesis has been used to modify the cysteine residues of recombinant Escherichia coli-derived IL-2 (rIL-2) to evaluate the functional structure of IL-2. Substitution or deletion of cysteine 105 disrupted the disulfide bridge and yielded a mutant protein which was 8-10 times less active than wild type rIL-2. A similar modification at position 58, however, reduced the activity of rIL-2 by more than 250-fold. Although substitution of serine for cysteine 125 did not affect IL-2 activity, deletion of cysteine 125 or deletion of amino acids in the vicinity of this cysteine yielded mutant proteins with little, if any, activity. These results indicate that the protein structure in the vicinity of both positions 58 and 125 is more critical than that close to position 105. These findings may provide a clue to the understanding of the functional structure of human IL-2.
Transoil Technology for Heavy Oil Transportation: Results of Field Trials at Wolf Lake (1988)

ABSTRACT Since 1982, BP Research International has been investigating the suitability of oil-in-water emulsion technology for the transportation of heavy oils and bitumens as part of a collaborative research agreement with Intevep S.A., an affiliate of Petroleos de Venezuela S.A. During the course of this work, in 1983, a new method for the preparation of stable oil-in-water emulsions was discovered. Patent applications for the process have been filed in appropriate countries. Encouraged by the results of a substantial programme of laboratory and small-scale pilot plant research at the Sunbury Research Centre of BP Research International, a Joint Venture was established in 1987 between BP Canada, the Alberta Energy Company and BP Canadian Holdings to develop and demonstrate TRANSOIL technology at Wolf Lake, Alberta, Canada. The development programme has recently been completed in trials designed to evaluate the scale-up of the TRANSOIL emulsification process, the storage properties of the emulsions produced, their transportation characteristics and their ultimate demulsification. This paper describes the background to the technology, the facilities used and the results obtained during the trials.