gebhart/patrepeval huggingface dataset:
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy (2014)

Mesenchymal stem cells (MSCs) are a pleiotropic population of cells that are self-renewing and capable of differentiating into canonical cells of the mesenchyme, including adipocytes, chondrocytes, and osteocytes. They employ multi-faceted approaches to maintain bone marrow niche homeostasis and promote wound healing during injury. Biomedical research has long sought to exploit their pleiotropic properties as a basis for cell therapy for a variety of diseases and to facilitate hematopoietic stem cell establishment and stromal reconstruction in bone marrow transplantation. Early results demonstrated their usage as safe, and there was little host response to these cells. The discovery of their immunosuppressive functions ushered in a new interest in MSCs as a promising therapeutic tool to suppress inflammation and down-regulate pathogenic immune responses in graft-versus-host and autoimmune diseases such as multiple sclerosis, autoimmune diabetes, and rheumatoid arthritis. MSCs produce a large number of soluble and membrane-bound factors, some of which inhibit immune responses. However, the full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease. The present review describes the large body of literature that has been accumulated on the fascinating biology of MSCs and their complex effects on immune responses.
Gravitational Radiation from Colliding Black Holes (1971)

It is shown that there is an upper bound to the energy of the gravitational radiation emitted when one collapsed object captures another. In the case of two objects with equal masses $m$ and zero intrinsic angular momenta, this upper bound is $(2\ensuremath{-}\sqrt{2})m$.
Proteomics of industrial fungi: trends and insights for biotechnology (2010)

Filamentous fungi are widely known for their industrial applications, namely, the production of food-processing enzymes and metabolites such as antibiotics and organic acids. In the past decade, the full genome sequencing of filamentous fungi increased the potential to predict encoded proteins enormously, namely, hydrolytic enzymes or proteins involved in the biosynthesis of metabolites of interest. The integration of genome sequence information with possible phenotypes requires, however, the knowledge of all the proteins in the cell in a system-wise manner, given by proteomics. This review summarises the progress of proteomics and its importance for the study of biotechnological processes in filamentous fungi. A major step forward in proteomics was to couple protein separation with high-resolution mass spectrometry, allowing accurate protein quantification. Despite the fact that most fungal proteomic studies have been focused on proteins from mycelial extracts, many proteins are related to processes which are compartmentalised in the fungal cell, e.g. β-lactam antibiotic production in the microbody. For the study of such processes, a targeted approach is required, e.g. by organelle proteomics. Typical workflows for sample preparation in fungal organelle proteomics are discussed, including homogenisation and sub-cellular fractionation. Finally, examples are presented of fungal organelle proteomic studies, which have enlarged the knowledge on areas of interest to biotechnology, such as protein secretion, energy production or antibiotic biosynthesis.
A PvuII RFLP for the human liver arginase (ARG1) gene (1986)

Liver Arginase (ARG1), a 1550 bp cDNA clone--Cl 6B--was isolated from a human liver-derived cDNA library. The vector is pKT218 (Michelson et al., 1983).
HMD Viewing Spherical Video Streaming System (2014)

We propose a video streaming system that lets users view their favorite sections through an HMD (head mount display) from a video recorded by a spherical (360-degree) camera. Although spherical video streaming tends to consume a lot of bitrate for its huge image area, our system consumes a reasonable amount of bitrate by assigning higher bitrate only for the user's viewing area, not for the area outside of it. Technical Demos of the system with an Oculus Rift HMD will be performed to demonstrate it enables them to view images at a bitrate of about 2.5 Mbps.
Wavelet brain angiography suggests arteriovenous pulse wave phase locking (2017)

When a stroke volume of arterial blood arrives to the brain, the total blood volume in the bony cranium must remain constant as the proportions of arterial and venous blood vary, and by the end of the cardiac cycle an equivalent volume of venous blood must have been ejected. I hypothesize the brain to support this process by an extraluminally mediated exchange of information between its arterial and venous circulations. To test this I introduce wavelet angiography methods to resolve single moving vascular pulse waves (PWs) in the brain while simultaneously measuring brain pulse motion. The wavelet methods require angiographic data acquired at significantly faster rate than cardiac frequency. I obtained these data in humans from brain surface optical angiograms at craniotomy and in piglets from ultrasound angiograms via cranial window. I exploit angiographic time of flight to resolve arterial from venous circulation. Initial wavelet reconstruction proved unsatisfactory because of angiographic motion alias from brain pulse motion. Testing with numerically simulated cerebral angiograms enabled the development of a vascular PW cine imaging method based on cross-correlated wavelets of mixed high frequency and high temporal resolution respectively to attenuate frequency and motion alias. Applied to the human and piglet data, the method resolves individual arterial and venous PWs and finds them to be phase locked each with separate phase relations to brain pulse motion. This is consistent with arterial and venous PW coordination mediated by pulse motion and points to a testable hypothesis of a function of cerebrospinal fluid in the ventricles of the brain.
Central glucagon-like peptide-I in the control of feeding (1996)

Conference Article| May 01 1996 Central glucagon-like peptide-I in the control of feeding I. Gunn; I. Gunn 1Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. O'Shea; D. O'Shea 1Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, U.K. Search for other works by this author on: This Site PubMed Google Scholar M. D. Turton; M. D. Turton 1Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. A. Beak; S. A. Beak 1Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, U.K. Search for other works by this author on: This Site PubMed Google Scholar S. R. Bloom S. R. Bloom 1Division of Endocrinology, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (2): 581–584. https://doi.org/10.1042/bst0240581 Article history Received: December 21 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation I. Gunn, D. O'Shea, M. D. Turton, S. A. Beak, S. R. Bloom; Central glucagon-like peptide-I in the control of feeding. Biochem Soc Trans 1 May 1996; 24 (2): 581–584. doi: https://doi.org/10.1042/bst0240581 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: NPY, neuropeptide Y, GLP-1, glucagon-like peptide-1 (7–36) amide, ICV, intracer-ebroventricular, PVN, paraventricular nucleus of the hypothalamus, CeA, central nucleus of the amydala This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Residues Determining the Binding Specificity of Uncompetitive Inhibitors to Tissue-Nonspecific Alkaline Phosphatase (2004)

We found that the identity of residue 108 in TNALP largely determines the specificity of inhibition by L-hArg. The conserved Tyr-371 is also necessary for binding of L-hArg. In contrast, the binding of levamisole to TNALP is mostly dependent on His-434 and Tyr-371, but not on residues 108 or 109. The main determinant of sensitivity to theophylline is His-434. Thus, we have clarified the location of the binding sites for all three TNALP inhibitors, and we have also been able to exchange inhibitor specificities between TNALP and PLALP. These data will enable drug design efforts aimed at developing improved, selective, and drug-like TNALP inhibitors for therapeutic use.
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ (2001)

Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Abeta amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants. Transfected HN cDNA was transcribed to the corresponding polypeptide and then was secreted into the cultured medium. The rescue action clearly depended on the primary structure of HN. This polypeptide would serve as a molecular clue for the development of new therapeutics for Alzheimer's disease targeting neuroprotection.
Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells (1994)

The expression of the low-affinity NGF receptor (p75) and the trkA proto-oncogene product was analyzed in a series of human hematopoietic cell lines at protein and RNA levels. We did not detect any form of NGF receptor in cell lines displaying a myelomonocytic phenotype (HL60 and U937). In contrast, cells displaying a more immature erythroleukemic phenotype (TF1 and K562) expressed TrkA in the absence of detectable p75. Scatchard analysis showed a single high-affinity site for NGF (kd = 10(-10) mol/L), with a copy number ranging from 300 to 3,000 sites per cell depending on the studied cell line. In addition, NGF induced autophosphorylation of TrkA and could substitute for granulocyte- monocyte colony-stimulating factor to trigger the proliferation of the TF1 cell line, with a half-maximal signal observed at 50 pmol/L, indicating that p75 is not required for DNA synthesis in this cell line. The physiologic relevance of NGF in early hematopoiesis was confirmed by showing that 12% to 15% of progenitor blood cells from mice treated with 5-fluorouracil expressed TrkA and that these cells could be induced to proliferate and differentiate in response to NGF in association with macrophage colony-stimulating factor. Our study demonstrates for the first time that trkA proto-oncogene expression and activation is not restricted to the nervous system, but is also an important element in early hematopoiesis.
Influence of Variable N-Glycosylation on the Cytolytic Potential of Chimeric CD19 Antibodies (2006)

To investigate the influence of N-linked oligosaccharides at asparagines-297 on the cytolytic potential of chimeric CD19 antibodies, three distinct variants were generated by production in different expression systems. The same chimeric CD19 antibody was produced in Sf21 insect cells, human 293 T cells, and 293 T cells expressing a co-transfected beta1,4-N-acetylglucosaminyltransferase III (GnTIII). The N-glycan structures and the cytolytic potential of the antibodies produced in these three systems were directly compared. After expression in insect cells, the antibody carried paucimannosidic N-linked oligosaccharides, distinct from the complex biantennary carbohydrate moieties attached to the product from human cells. After co-expression with GnTIII in human cells, the antibody carried an eightfold greater percentage of oligosaccharides with a bisecting N-acetylglucosamine (78.7% versus 9.6%) and a 30-fold increased proportion of bisecting, defucosylated oligosaccharides (15.9% versus 0.5%). The insect cell product triggered stronger antibody-dependent cellular cytotoxicity (ADCC) of a human leukemia-derived cell line than the product from non-re-engineered 293 T cells and was equally effective at 50- to 100-fold lower concentrations. The antibody from glyco-engineered 293 T cells had comparable lytic activity as the insect cell product. Both mediated significant ADCC at lower effector-to-target cell ratios than the antibody from non-re-engineered 293 T cells, and both were highly effective against primary blasts from pediatric leukemia patients. The data demonstrate the influence of the N-glycosylation pattern on the ADCC activity of chimeric CD19 antibodies and point to the importance of suitable expression systems for the production of highly active therapeutic antibodies.
Ultrafast Molecule Separation through Layered WS2 Nanosheet Membranes (2014)

Two-dimensional layered materials have joined in the family of size-selective separation membranes recently. Here, chemically exfoliated tungsten disulfide (WS2) nanosheets are assembled into lamellar thin films and explored as an ultrafast separation membrane for small molecules with size of about 3 nm. Layered WS2 membranes exhibit 5- and 2-fold enhancement in water permeance of graphene oxide membranes and MoS2 laminar membranes with similar rejection, respectively. To further increase the water permeance, ultrathin nanostrands are used as templates to generate more fluidic channel networks in the WS2 membrane. The water permeation behavior and separation performance in the pressure loading-unloading process reveal that the channels created by the ultrathin nanostrands are cracked under high pressure and result in a further 2-fold increase of the flux without significantly degrading the rejection for 3 nm molecules. This is supported by finite-element-based mechanical simulation. These layered WS2 membranes demonstrate up to 2 orders of magnitude higher separation performance than that of commercial membranes with similar rejections and hold the promising potential for water purification.
High-end CMOS active pixel sensor for hyperspectral imaging (2005)

Solid-state optical sensors are used in the space environment for a wide range of applications. Many applications still rely on charge coupled device (CCD) technology, but CMOS active pixel sensors (APS) offer great promise for use in space-borne imaging instruments. This paper highlights an ongoing development under ESA contract for a high-end CMOS APS sensor optimized for hyperspectral imaging in space [1].
Controlled Electrophoretic Deposition of Smooth and Robust Films of CdSe Nanocrystals (2003)

Controlled purification of the CdSe nanocrystal primitive solution critically affects the electrophoretic deposition of these nanocrystals. Film morphology is optimized after two precipitation steps with no TOPO/TOP added in either step. This suggests the need to minimize impurities in the solution or to remove a controlled, small fraction of the ligands on the nanocrystal surface. The smoothness of electrophoretically deposited nanocrystal films is excellent (<3 nm rms roughness) and the appearance of particulates of nanocrystals due to homogeneous nucleation is minimized, even during patterned deposition. Treating the films with cross-linker molecules makes the electrophoretically deposited films very resistant to dissolution and flaking in many solvents.
NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. (1993)

Recent evidence suggests that sulfhydryl species can react with oxides of nitrogen under physiologic conditions and thereby stabilize endothelium-derived relaxing factor (EDRF) activity, but the presence of a specific in vivo thiol carrier for nitric oxide (NO) remains controversial. The single free sulfhydryl of serum albumin is the most abundant thiol species in plasma (approximately 0.5 mM) and is particularly reactive towards NO. To examine the potential role of serum albumin in endogenous nitric oxide metabolism, we synthesized S-nitroso-BSA (S-NO-BSA), a model S-nitroso-protein, and examined its effects on platelet function and coronary and systemic vascular tone in 16 mongrel dogs. Intravenous bolus S-NO-BSA markedly reduced mean arterial pressure in a dose-dependent manner and proved seven and a half-fold less potent than intravenous nitroglycerin and 10-fold less potent than intravenous S-nitroso-cysteine (half-maximal response of 75 nmol/kg compared to 10 and 7.5 nmol/kg, respectively; P < 0.05); when given by intravenous infusion (half-maximal response = 10 nmol/kg per min), however, S-NO-BSA and nitroglycerin were equipotent. Intravenous bolus S-NO-BSA had a greater duration of action than either nitroglycerin or S-nitroso-cysteine and produced marked prolongation of the template bleeding time associated with dose-dependent inhibition of ex vivo platelet aggregation (half-maximal response approximately 70 nmol/kg). Intracoronary S-NO-BSA increased coronary blood flow (mean +/- SEM) less effectively than nitroprusside, acetylcholine, or S-nitroso-cysteine (165% +/- 24% vs. 315% +/- 82%, 483% +/- 55%, or 475% +/- 66%, respectively; P < 0.05) although with much longer duration of action. On a molar basis, S-nitroso-cysteine proved more effective than S-nitroso-BSA, nitroprusside, or acetylcholine as an epicardial coronary vasodilator. Thus, serum albumin reacts with oxides of nitrogen to form a stable S-nitroso-thiol with properties reminiscent of authentic EDRF supporting the view that protein associated thiol may participate in the action and metabolism of EDRF.
Signature analyzers in built-in self-test circuits: a perspective (2002)

The test response compression technique using signature analyzers or linear feedback shift registers (LFSRs) is discussed and some representative built-in self-test (BIST) designs which make use of LFSRs are presented. Signature analysis is a compression technique based on the concept of cyclic redundancy checking (CRC) and realized in hardware using LFSRs. The input to the LFSR is received from the output of a multiple input single output circuit under test (CUT). The structure and characteristics of LFSRs including a simplified mathematical analysis showing the confidence level in detecting faults are discussed. Some BIST design examples which include a programmable logic array, semiconductor memory, and a microcomputer are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Creativity and Fluency Therapy (2001)

No AccessPerspectives on Fluency and Fluency DisordersArticle1 Jan 2001Creativity and Fluency Therapy Phillip Schneider Phillip Schneider Queens College, The City University of New York Google Scholar More articles by this author https://doi.org/10.1044/ffd11.1.13 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationTrack Citations ShareFacebookTwitterLinked In "Creativity and Fluency Therapy." Perspectives on Fluency and Fluency Disorders, 11(1), pp. 13–14 Additional Resources FiguresReferencesRelatedDetailsCited ByPerspectives on Fluency and Fluency Disorders13:2 (14-17)1 Dec 2003Counseling School-Age Children Who StutterPhillip Schneider Volume 11Issue 1January 2001Pages: 13-14 Get Permissions Add to your Mendeley library History Published in issue: Jan 1, 2001 Metrics Topicsasha-topicsleader-topicsasha-sigsasha-article-typesCopyright & Permissions© 2001 American Speech-Language-Hearing AssociationPDF DownloadLoading ...
Law, Religion and Medicine: Conjunctive or Disjunctive? (2006)

From virtually the beginning of his public career in the Australian Law Reform Commission, Justice Michael Kirby was called upon to address vital and complex issues in health law and ethics. Indeed, it may be seen that the whole national debate of how best to renew the legal system in order to ensure its fairness accessibility and continued relevance in the Age of Biomedical Technology was begun on his 'watch'.
Evaluation of The Usefulness of Testing for P53 Mutations in Colorectal Cancer Surveillance for Ulcerative Colitis (1999)

p53 Mutations 1) are associated with, and likely precede, dysplasia and cancer, 2) are associated with cancer-related mortality, and 3) may possibly be prevented by folic acid supplementation.
Josephson frequency singularity in the noise of normal-metal–superconductor junctions (1999)

A singularity at the Josephson frequency in the noise spectral density of a disordered normal-metal--superconductor junction is predicted for bias voltages below the superconducting gap. The nonstationary Aharonov-Bohm effect, recently introduced for normal metals [G. B. Lesovik and L. S. Levitov, Phys. Rev. Lett. 72, 538 (1994)], is proposed as a tool for detecting this singularity. In the presence of a harmonic external field, the derivative of the noise with respect to the voltage bias reveals jumps when the applied frequency is commensurate with the Josephson frequency associated with this bias. The height of these jumps is nonmonotonic in the amplitude of the periodic field. The superconducting flux quantum enters this dependence. Additional singularities in the frequency dependent noise are predicted above gap.
Sulfonate-Containing Thiiranes as Selective Gelatinase Inhibitors (2010)

Matrix metalloproteinases (MMPs) are important zinc-dependent endopeptidases. Two members of this family of enzymes called gelatinases (MMP-2 and MMP-9) have been implicated in a number of human diseases, including cancer, neurological and cardiovascular diseases, and inflammation, to name a few. We describe in this report the preparation and evaluation of two structural types of thiirane inhibitors that show selectivity toward gelatinases. The biphenyl series targets both gelatinases, whereas the monophenyl analogues exhibit potent inhibition of only MMP-2. The latter structural type also exhibits improved water solubility and metabolic stability, both traits desirable for progress of these molecules forward in gelatinase-dependent animal models of disease.
The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor (2010)

Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context. Hence, Mdm2 is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.
The role of the vertebral venous system in the metastasis of cancer to the spinal column.Experiments with tumor-cell suspensions in rats and rabbits (1951)

F ROM previous experi~ncnts~ carried out in this laboratory on animals, it has been concluded that the anatomical distribution of metastases depends chiefly upon the availability of tumor-cell emboli rather than upon variation in the susceptibility of different organs to the growth of secondary tuniors. I t has further been concluded that the frequencies of nietastases in the various organs are correlated positively with the number of cmholic tumor cells that reach tlie capillary bed.3 l'hese conclusions have been advanced to account for the frequency 01 nietastases in some organs aiicl their infrequency in other orgins.