gebhart/patrepeval huggingface dataset:
Perception and human interaction for developmental learning of objects and affordances (2012)

In this paper we describe a cognitive architecture for humanoids interacting with objects and caregivers in a developmental robotics scenario. The architecture is foundational to the MACSi project: it is designed to support experiments to make a humanoid robot gradually enlarge its repertoire of known objects and skills combining autonomous learning, social guidance and intrinsic motivation. This complex learning process requires the capability to learn affordances first. Here, we present the general framework for achieving these goals, focusing on the elementary action, perception and interaction modules. Preliminary experiments performed on the humanoid robot iCub are also discussed.
Reversal of Lysosomal Storage in Brain of Adult MPS-I Mice with Intravenous Trojan Horse-Iduronidase Fusion Protein (2011)

A mouse model of mucopolysaccharidosis (MPS) type I, which is null for the lysosomal enzyme, α-L-iduronidase (IDUA), is treated with intravenous, receptor-mediated enzyme replacement therapy of the brain. Murine IDUA, which does not cross the blood-brain barrier, is re-engineered for targeting to the brain as an IgG-enzyme fusion protein. The amino terminus of mature IDUA is fused to the carboxyl terminus of the heavy chain of a chimeric monoclonal antibody (mAb) against the murine transferrin receptor (TfR), and this fusion protein is designated cTfRMAb-IDUA. The cTfRMAb part of the fusion protein acts as a molecular Trojan horse to ferry the fused IDUA across the BBB and neuronal cell membrane via transport on the TfR. The IDUA enzyme activity of the fusion protein, 776 ± 79 units/μg protein, is comparable to recombinant IDUA. MPSI null mice, 6-8 months of age, were treated iv twice a week for 8 weeks with either saline or 1 mg/kg cTfRMAb-IDUA. The glycosoaminoglycan levels in liver, spleen, heart, and kidney were reduced by >95%, 80%, 36%, and 20%, respectively. Lysosomal inclusion bodies in the brain were quantitated from semithin sections stained with o-toluidine blue and normalized per 100 nucleoli per brain section. Treatment of the MPSI mice with the cTfRMAb-IDUA reduced intracellular lysosomal inclusion bodies by 73% in brain, as compared to the MPSI mice treated with saline. In conclusion, the reversal of pre-existing neural pathology in the brain of MPSI mice is possible with receptor-mediated enzyme replacement therapy of the brain.
A distributed memory MIMD multi-computer with reconfigurable custom computing capabilities (2002)

Armstrong III is a multi node multi-computer designed and built at the Laboratory for Engineering Man/Machine System (LEMS) of Brown University. Each node contains a RISC processor and reconfigurable resources implemented with FPGAs. The primary benefit in using FPGAs is that the resulting hardware is neither rigid nor permanent but is in-circuit reprogrammable. This allows each node to be tailored to the computational requirements of an application. This paper describes the Armstrong III architecture and concludes with a substantive example application that performs HMM Training for speech recognition with the reconfigurable platform.
Excessive fluid intake as a novel cause of proteinuria (2008)

As part of a community screening study to assess the long-term health outcomes among residents of Walkerton, Ontario, after contamination of its municipal water supply by Escherichia coli O157:H7 and Campylobacter in 2000, we identified 100 adults who had proteinuria and polyuria but no medical history or medication use to explain their condition. Fifty-six of the 100 participants underwent both initial and confirmatory urine concentration tests, which showed that their urine osmolality could reach normal levels. We then instructed them to reduce their fluid intake to less than 2 L/d for 1 week. The proteinuria and polyuria were largely reversed by this manoeuvre. We do not know at this time whether the proteinuria associated with excessive fluid intake in these otherwise healthy people will affect their kidney function in the long term.
ChemInform Abstract: Salt‐Templated Open Frameworks (CU‐2): Novel Phosphates and Arsenates Containing M3(X2O7)22‐ (M: Mn, Cu; X: P, As) Micropores 5.3 Å and 12.7 Å in Diameter. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes (2005)

sNORPEG is expressed in different developmental stages of the testis and encodes a protein that may have roles in human testis development and spermatogenesis.
On the Antioxidant Mechanism of Curcumin:  Classical Methods Are Needed To Determine Antioxidant Mechanism and Activity (2000)

[reaction: see structure] The antioxidant activity of curcumin (1, 7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition of controlled initiation of styrene oxidation. Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore, curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH(2) group as has been suggested (Jovanovic et al. J. Am. Chem. Soc. 1999, 121, 9677). The antioxidant activities of o-methoxyphenols are decreased in hydrogen bond accepting media.
Recent developments in bio-inspired special wettability (2010)

Nature is a school for scientists and engineers. After four and a half billion years of stringent evolution, some creatures in nature exhibit fascinating surface wettability. Biomimetics, mimicking nature for engineering solutions, provides a model for the development of functional surfaces with special wettability. Recently, bio-inspired special wetting surfaces have attracted wide scientific attention for both fundamental research and practical applications, which has become an increasingly hot research topic. This Critical Review summarizes the recent work in bio-inspired special wettability, with a focus on lotus leaf inspired self-cleaning surfaces, plants and insects inspired anisotropic superhydrophobic surfaces, mosquito eyes inspired superhydrophobic antifogging coatings, insects inspired superhydrophobic antireflection coatings, rose petals and gecko feet inspired high adhesive superhydrophobic surfaces, bio-inspired water collecting surfaces, and superlyophobic surfaces, with particular focus on the last two years. The research prospects and directions of this rapidly developing field are also briefly addressed (159 references).
Human sperm sex selection (1994)

Journal Article Human sperm sex selection: Safety of human sperm selection by flow cytometry Get access M .J. Ashwood-Smith M .J. Ashwood-Smith University of VictoriaVictoria, British Columbia V8W 2Y2, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Reproduction, Volume 9, Issue 5, 1 May 1994, Page 757, https://doi.org/10.1093/oxfordjournals.humrep.a138589 Published: 01 May 1994
Reconfigurable Physical Unclonable Functions - Enabling technology for tamper-resistant storage (2009)

A PUF or Physical Unclonable Function is a function that is embodied in a physical structure that consists of many random uncontrollable components which originate from process variations during manufacturing. Due to this random structure a physical stimulus or challenge generates unpredictable responses. Because of their physical properties PUFs are unclonable and very promising primitives for the purpose of authentication and storage of cryptographic keys. Previous work on PUFs considers mainly static challenge-response PUFs. In many applications, however, a dynamic PUF would be desirable, e.g., in order to allow the key derived from the PUF to be updated. We define a new primitive, the reconfigurable PUF (rPUF) which is a PUF with a mechanism to transform it into a new PUF with a new unpredictable and uncontrollable challenge-response behavior, even if the challengeresponse behavior of the original PUF is already known. We present two practical instantiations of a reconfigurable PUF. One is a new variant of the optical PUF, and the other is based on phase change memory. We also illustrate how an rPUF can be used to protect non-volatile storage against invasive physical attacks.
Study on Spectral Response and Estimation of Grassland Plants Dust Retention Based on Hyperspectral Data (2020)

Accurate monitoring of plant dust retention can provide a basis for dust pollution control and environmental protection. The aims of this study were to analyze the spectral response features of grassland plants to mining dust and to predict the spatial distribution of dust retention using hyperspectral data. The dust retention content was determined by an electronic analytical balance and a leaf area meter. The leaf reflectance spectrum was measured by a handheld hyperspectral camera, and the airborne hyperspectral data were obtained using an imaging spectrometer. We analyzed the difference between the leaf spectral before and after dust removal. The sensitive spectra of dust retention on the leaf- and the canopy-scale were determined through two-dimensional correlation spectroscopy (2DCOS). The competitive adaptive reweighted sampling (CARS) algorithm was applied to select the feature bands of canopy dust retention. The estimation model of canopy dust retention was built through random forest regression (RFR), and the dust distribution map was obtained based on the airborne hyperspectral image. The results showed that dust retention enhanced the spectral reflectance of leaves in the visible wavelength but weakened the reflectance in the near-infrared wavelength. Caused by the canopy structure and multiple scattering, a slight difference in the sensitive spectra on dust retention existed between the canopy and leaves. Similarly, the sensitive spectra of leaves and the canopy were closely related to dust and plant physiological parameters. The estimation model constructed through 2DCOS-CARS-RFR showed higher precision, compared with genetic algorithm-random forest regression (GA-RFR) and simulated annealing algorithm-random forest regression (SAA-RFR). Spatially, the amount of canopy dust increased and then decreased with increasing distance from the mining area, reaching a maximum within 300–500 m. This study not only demonstrated the importance of extracting feature bands based on the response of plant physical and chemical parameters to dust, but also laid a foundation for the rapid and non-destructive monitoring of grassland plant dust retention.
Virus-specified protease in poliovirus-infected HeLa cells. (1979)

Previous studies have shown that primary cleavages in nascent picornavirus precursors are accomplished by cellular proteases. This study has characterized the enzyme in infected cells that produces the capsid polypeptides by secondary cleavages of viral precursors. The kinetics of the production of protease activity correlate with the time course of virus protein synthesis, and the new enzyme has characteristic pH and temperature optima. Guanidine and cycloheximide, which are inhibitors of virus RNA and protein synthesis, prevent production of the protease. As determined by introduction of amino acid analogs into the protease or inhibition by a leucyl chloromethyl ketone, the enzyme is synthesized at a time of infection when host cell proteins are not produced, and the enzyme copurified with a 40,000-dalton virus polypeptide present in the cytoplasm of infected cells. Wild-type levels of protease activity are produced by viral mutants that are defective in coat protein synthesis. The conclusion is that a non-structural poliovirus gene product participates in protein cleavages that produce the viral coat proteins.
Role of B70/B7-2 in CD4+ T-cell immune responses induced by dendritic cells. (1995)

Dendritic cells (DC) are potent antigen-presenting cells (APC). However, the molecular basis underlying this activity remains incompletely understood. To address this question, we generated murine monoclonal antibodies (mAb) against human peripheral blood-derived DC. One such antibody, designated IT209, stained differentiated DC and adherent monocytes, but failed to stain freshly isolated peripheral blood mononuclear cells (PBMC). The antigen recognized by IT209 was identified as B70 (B7-2; also recently identified as CD86). Using this mAb we studied the role of B70 in CD4+ T-cell activation by DC in vitro. IT209 partly inhibited the proliferative response of CD4+ T cells to allogeneic DC and to recall antigens, such as tetanus toxoid (TT) and purified protein derivative (PPD) of tuberculin, presented by autologous DC. More importantly, the mAb had a potent inhibitory effect on the primary response of CD4+ T cells to autologous DC pulsed with human immunodeficiency virus (HIV) gp160 or keyhole limpet haemocyanin (KLH). Adherent monocytes, despite their expression of B70, failed to induce T-cell responses to these antigens. IT209-mediated inhibition of CD4+ T-cell responses was equivalent to that produced by anti-CD25 mAb, whereas an anti-CD80 mAb was only marginally inhibitory and did not augment the effect of IT209. These findings indicate that the B70 antigen plays an important role in DC-dependent CD4+ T-cell activation, particularly in the induction of primary CD4+ T-cell responses to soluble antigens. However, since activated monocytes, despite their expression of B70, failed to prime naive T cells to these antigens, our results suggest that additional molecules contribute to the functions of DC in CD4+ T-cell activation.
Biology of soft tissue wound healing and regeneration – Consensus Report of Group 1 of the 10th European Workshop on Periodontology (2014)

The use of barriers membranes, growth and differentiation factors and soft tissue substitutes for the treatment of localized gingival/mucosal recessions, insufficient amount of keratinized tissue and insufficient soft tissue volume is at a developing stage.
A Precisely Controlled DNA Biped Walking Device (2004)

We present an experimental realization of a molecular walking motor built from DNA. The device consists of a biped and a well-defined track where it walks. Input DNA strands act as a convenient interface to allow precise control of the biped walking forward or backward. Psoralen molecules are attached to the ends of the feet in synthesis. When irradiated, the psoralen molecules cross-link strands covalently, allowing unambiguous determination of the state of the walker.
Respiratory burst oxidase of fertilization. (1989)

Partially reduced oxygen species are toxic, yet sea urchin eggs synthesize H2O2 in a "respiratory burst" at fertilization, as an extracellular oxidant to crosslink their protective surface envelopes. To study the biochemical mechanism for H2O2 production, we have isolated an NADPH-specific oxidase fraction from homogenates of unfertilized Strongylocentrotus purpuratus eggs that produces H2O2 when stimulated with Ca2+ and MgATP2-. Concentrations of free Ca2+ previously implicated in regulation of egg activation modulate the activity of the oxidase. Inhibitors were used to test the relevance of this oxidase to the respiratory burst of fertilization. Procaine, two phenothiazines, and N-ethylmaleimide (but not iodoacetamide) inhibited H2O2 production by the oxidase fraction and oxygen consumption by activated eggs. The ATP requirement suggested that protein kinase activity might regulate the respiratory burst of fertilization; consonant with this hypothesis, H-7 and staurosporine were inhibitory. The respiratory burst oxidase of fertilization is an NADPH:O2 oxidoreductase that appears to be regulated by a protein kinase; although it bears a remarkable resemblance to the neutrophil oxidase, unlike the latter it does not form O2- as its initial product.
Synthesis of Poly(isobutylene-block-methyl methacrylate) by a Novel Coupling Approach (2006)

The synthesis of poly(isobutylene-b-methyl methacrylate) has been accomplished by a novel coupling approach combining living cationic and anionic polymerization techniques. By capping living polyisobutylene (PIB) with 1,3-butadiene, a chloroallyl chain-end-functionalized PIB (PIB−AllylCl) was prepared. Coupling of the purified and isolated product and living poly(methyl methacrylate) (PMMALi) was then attempted in tetrahydrofuran at −78 °C. However, coupling was absent, and the addition of cesium iodide as a catalyst to increase the coupling rate was also unsuccessful. Halogen exchange reaction of PIB−AllylCl using an excess of lithium bromide proceeded quantitatively to yield the bromoallyl counterpart (PIB−AllylBr). The PIB−AllylBr was coupled with PMMALi in THF at −78 °C with high efficiency (>95%) and yielded the expected diblock copolymer.
Human Malaria in Immunocompromised Mice (2000)

We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect.Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falciparum parasitemia similarly to that reported in humans, but only when mice are concomitantly reconstituted with human monocytes (HuMNs). In contrast, neither HI-IgGs nor HuMNs alone had any direct effect upon parasitemia. We assessed the in vivo effect of epitope-specific human Abs affinity-purified on peptides derived either from the ring erythrocyte surface antigen (RESA) or the merozoite surface protein 3 (MSP3). The inoculation of low concentrations of anti-synthetic peptide from MSP3, but not of anti-RESA Abs, consistently suppressed P. falciparum in the presence of HuMNs. Parasitemia decrease was stronger and faster than that observed using HI-IgGs and as fast as that induced by chloroquine. Our observations demonstrate that this mouse model is of great value to evaluate the protective effect of different Abs with distinct specificity in the same animal, a step hardly accessible and therefore never performed before in humans.
Gohard-Radenkovic, Aline, Communiquer en langue étrangère: de compétences culturelles vers des compétences linguistiques. Bern, Berlin, Bruxelles, Frankfurt/M., New York, Wien: Peter Lang, 1999, xviii + 253 pp. 3 906762 58 0 (2003)

Gohard-Radenkovic, Aline, Communiquer en langue étrangère: de compétences culturelles vers des compétences linguistiques. Bern, Berlin, Bruxelles, Frankfurt/M., New York, Wien: Peter Lang, 1999, xviii + 253 pp. 3 906762 58 0 - Volume 13 Issue 1
Isolation and Characterization of Herbicide Resistant Mutants in the Cyanobacterium Synechococcus R2 (1987)

A variety of mutants which are resistant to triazine - and urea - classes of herbicides have been isolated in the cyanobacterium Synechococcus R2. All the mutants that have been analyzed, show some cross-resistance to different herbicides suggesting that these herbicides share a common binding site in photosystem II. Three psbA genes have been identified in Synechococcus R2. The psbA-copy I gene was cloned from three mutants and used in DNA-mediated genetic transformation. It was found that in all three mutants this gene could transfer the mutation for herbicide resistance indicating that this gene codes for the herbicide resistant protein.
Economic Models and Algorithms for Distributed Systems (2009)

Modern computing paradigms have frequently adopted concepts from distributed systems. The quest for scalability, reliability and cost reduction has led to the development of massively distributed systems, which extend organisational boundaries. Voluntary computing environments (such as BOINC), Grids (such as EGEE and Globus), and more recently Cloud Computing (both open source and commercial) have established themselves as a range of distributed systems.
Tuning the Gap of a Superconducting Flux Qubit (2009)

We experimentally demonstrate the in situ tunability of the minimum energy splitting (gap) of a superconducting flux qubit by means of an additional flux loop. Pulses applied via a local control line allow us to tune the gap over a range of several GHz on a nanosecond time scale. The strong flux sensitivity of the gap (up to approximately 0.7 GHz/mPhi0) opens up the possibility to create different types of tunable couplings that are effective at the degeneracy point of the qubit. We investigate the dependence of the relaxation time and the Rabi frequency on the qubit gap.
Photothermal Properties of Gold Nanoparticles (2007)

This paper describes our recent time-resolved spectroscopy studies of the properties of gold particles at high laser excitation levels. In these experiments, an intense pump laser pulse rapidly heats the particle, creating very high lattice temperatures — up to the melting point of bulk gold. These high temperatures can have dramatic effects on the particle and the surroundings. The lattice temperature created is determined by observing the coherently excited the vibrational modes of the particles. The periods of these modes depend on temperature, thus, they act as an internal thermometer. We have used these experiments to provide values for the threshold temperatures for explosive boiling of the solvent surrounding the particles, and laser induced structural transformations in non-spherical particles. The results of these experiments are relevant to the use of metal nanoparticles in photothermal therapy, where laser induced heating is used to selectively kill cells.
Phosphorylation of Casein Kinase II by p34cdc2 (1995)

The alpha and beta subunits of casein kinase II are dramatically phosphorylated in cells that are arrested in mitosis (Litchfield, D. W., Lüscher, B., Lozeman, F. J., Eisenman, R. N., and Krebs, E.G. (1992) J. Biol. Chem. 267, 13943-13951). Comparative phosphopeptide mapping experiments indicated that the mitotic phosphorylation sites on the alpha subunit of casein kinase II can be phosphorylated in vitro by p34cdc2. In the present study, we have demonstrated that a glutathione S-transferase fusion protein encoding the C-terminal 126 amino acids of the alpha subunit is phosphorylated by p34cdc2 at the same sites as intact casein kinase II, indicating that the mitotic phosphorylation sites are localized within the C-terminal domain of alpha. Four residues within this domain, Thr-344, Thr-360, Ser-362, and Ser-370, conform to the minimal consensus sequence for p34cdc2 phosphorylation. Synthetic peptides corresponding to regions of alpha that contain each of these residues are phosphorylated by p34cdc2 at these sites. Furthermore, alterations in the phosphorylation of the glutathione S-transferase proteins encoding the C-terminal domain of alpha are observed when any of the four residues are mutated to alanine. When all four residues are mutated to alanine, the fusion protein is no longer phosphorylated by p34cdc2 at any of the sites that are phosphorylated in mitotic cells. These results indicate that Thr-344, Thr-360, Ser-362, and Ser-370 are the sites on the alpha subunit of casein kinase II that are phosphorylated in mitotic cells.
Outcomes in RBC transfusion‐dependent patients with Low‐/Intermediate‐1‐risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS‐004 study (2014)

These data support the clinical benefits and acceptable safety profile of lenalidomide in transfusion-dependent patients with IPSS-defined Low-/Int-1-risk MDS with isolated del(5q).