Myocardial Infarction in a Patient with a Hageman (Factor XII) Defect (1966)

Case Studies1 February 1966Myocardial Infarction in a Patient with a Hageman (Factor XII) DefectHELEN I. GLUECK, M.D., F.A.C.P., WALTER ROEHLL JR., M.D.HELEN I. GLUECK, M.D., F.A.C.P.Search for more papers by this author, WALTER ROEHLL JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-390 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis paper reports the occurrence of a myocardial infarction in a patient with an absolute deficiency of the Hageman factor (XII). Myocardial infarction has been described in two patients with hemophilia (VIII) (1, 2) and in a third, widespread atherosclerosis was found at autopsy (3). Likewise, myocardial infarction has recently been reported in a patient with plasma thromboplastin component (PTC) (IX) deficiency (4). To our knowledge, such an episode has not been reported in a patient with the Hageman defect. The simultaneous occurrence of these two disorders is of particular interest, since normally in vitro Hageman factor must be activated...References1. BORCHGREVINK CF: Myocardial infarction in a hemophiliac. Lancet 1: 1229, 1959. CrossrefMedlineGoogle Scholar2. BOIVIN JM: Infarctus du myocarde chez un hemophile. Arch. Mal. Coeur 47: 351, 1954. MedlineGoogle Scholar3. STEWARTACHESON JWED: Atherosclerosis in a hemophiliac. Lancet 1: 1121, 1957. CrossrefGoogle Scholar4. BRODYBEIZER JILH: Christmas disease and myocardial infarction. Arch. Intern. Med. (Chicago) 115: 552, 1965. CrossrefMedlineGoogle Scholar5. IVYSHAPIROMELNICK APP: The bleeding tendency in jaundice. Surg. Gynec. Obstet. 60: 781, 1935. Google Scholar6. LEEWHITE RIPD: A clinical study of the coagulation time of the blood. Amer. J. Med. Sci. 145: 495, 1913. CrossrefGoogle Scholar7. QUICK AJ: The Hemorrhagic Diseases. 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MACFARLANE RG: An enzyme cascade in the blood clotting mechanism, and its function as a biological amplifier. Nature (London) 202: 498, 1964. CrossrefMedlineGoogle Scholar21. WESSLERREIMER SSM: The role of human coagulation factors in serum-induced thrombosis. J. Clin. Invest. 39: 262, 1960. CrossrefMedlineGoogle Scholar22. HENDERSONRAPAPORT ESSL: The thrombotic activity of activation product. J. Clin. Invest. 41: 235, 1962. CrossrefMedlineGoogle Scholar23. BOTTIRATNOFF REOD: Studies on the pathogenesis of thrombosis: an experimental "hypercoagulable" state induced by the intravenous injection of ellagic acid. J. Lab. Clin. Med. 64: 385, 1964. MedlineGoogle Scholar24. CONNORHOAKWARNER WEJCED: Massive thrombosis produced by fatty acid infusion. J. Clin. Invest. 42: 860, 1964. CrossrefGoogle Scholar25. IATRIDISFERGUSONIATRIDIS PGJHSG: Surface factor mechanisms in relation to blood platelets: evidence that activated Hageman factor is present on the surface of platelets. Thromb. Diath. Haemorrh. 11: 355, 1964. MedlineGoogle Scholar26. BOYD WB: Pathology for the Physician. Lea & Febiger, Philadelphia, 1965, p. 76. Google Scholar27. PATTERSON JC: Pathologic correlations in impending infarction, in Anticoagulant Therapy in Ischemic Heart Disease, edited by NICHOL, E. S. Grune & Stratton, New York, 1965, p. 1. Google Scholar28. BOTTIRATNOFF REOD: The clot-promoting effect of soaps of long-chain saturated fatty acids. J. Clin. Invest. 42: 1569, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HELEN I. GLUECK, M.D., F.A.C.P.; WALTER ROEHLLJR., M.D.Affiliations: Cincinnati and Middletown, OhioFrom the Department of Medicine, University of Cincinnati College of Medicine, the Coagulation Laboratory, Cincinnati General Hospital, Cincinnati, Ohio, and the Middletown General Hospital, Middletown, Ohio.This study was supported by grants HE-02904-09 and H-6307 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Helen I. Glueck, M.D., Department of Medicine, J-4, Cincinnati General Hospital, Cincinnati, Ohio 45229. 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