gebhart/patrepeval huggingface dataset:
Piezoresistive signal down mixing for parallel detection of Si-based microcantilevers resonant frequencies (2005)

We have developed piezoresistive micro-cantilevers to be used as displacement or force sensors associated with self-detection onboard electronic system. The aim of our work was to realize an integrated and compact detection system without the need of optical read-out scheme. The electronics developed specifically for this application allows, when dynamically operated, to follow each piezoresistive microcantilever resonance frequency (by achieving in the same time an enhancement of the quality factor) with an accuracy of 0.34 Hz
Design of fully active FGF-1 variants with increased stability (2004)

Fibroblast growth factor 1 is a powerful mitogen playing an important role in morphogenesis, angiogenesis and wound healing and is therefore of potential medical interest. Using homologous sequence and structure comparisons, we designed and constructed 16 mutants of FGF-1 with increased thermodynamic stability, as determined by chemical and heat denaturation. For multiple mutants, additive effects on stability were observed, providing mutants up to 7.8 degrees C more stable than the wild-type. None of the introduced mutations affected any FGF-1 biological activities, such as stimulation of DNA synthesis, MAP kinase activation and binding to the FGF receptor on the cell surface. Our study provides a good starting point to improve the stability of FGF-1 in the context of its wide potential therapeutic applications. We showed that a homology approach is an effective method to change the thermodynamic properties of the protein without altering its function.
Concept Analysis of Pain (2003)

The purpose of this paper is to expand the understanding of tile concept of pain. The authors intent to clarify the defining attributes of pain and identify antecedents that influence the perception of pain and the possible consequences of pain by using Walker and Avant's (1995) concept analysis. A model case demonstrates how pain is tied to these critical attributes. A borderline case and a contrary case are presented to differentiate the concept of pain from other concepts. Empirical referents demonstrate the current perspective of the concept of pain.
Iteratively Trained Interactive Segmentation (2018)

Deep learning requires large amounts of training data to be effective. For the task of object segmentation, manually labeling data is very expensive, and hence interactive methods are needed. Following recent approaches, we develop an interactive object segmentation system which uses user input in the form of clicks as the input to a convolutional network. While previous methods use heuristic click sampling strategies to emulate user clicks during training, we propose a new iterative training strategy. During training, we iteratively add clicks based on the errors of the currently predicted segmentation. We show that our iterative training strategy together with additional improvements to the network architecture results in improved results over the state-of-the-art.
Molecular Characterization and Heterologous Expression of the Gene Encoding a Low-Molecular-Mass Endoglucanase from Trichoderma reesei QM9414 (1998)

We have isolated the genomic and cDNA clones encoding EG III (a low-molecular-mass endo-beta-1,4-glucanase) gene from Trichoderma reesei QM9414. The nucleotide sequence of the cDNA fragment was verified to contain a 702-bp open reading frame that encodes a 234-amino-acid propeptide. The deduced protein sequence has significant homologies with family H endo-beta-1,4-glucanases. The 16-amino-acid N-terminal sequence was shown to function as a leader peptide for possible secretion. Northern blot analysis showed that the EG III gene transcript, with a length of about 700 bp, was expressed markedly by cellulose but not by glucose. The protein has been expressed as a mature form in Escherichia coli and as secreted forms in Saccharomyces cerevisiae and Schizosaccharomyces pombe under the control of tac, alcohol dehydrogenase (ADH1), and human cytomegalovirus promoters, respectively. The S. cerevisiae and Schizosaccharomyces pombe recombinant strains showed strong cellulolytic activities on agar plates containing carboxymethyl cellulose. The E. coli strain expressed small amounts of EG III in an active form and large amounts of EG III in an inactive form. The molecular masses of the recombinant EG IIIs were estimated to be 25, 28, and 29 kDa for E. coli, S. cerevisiae, and Schizosaccharomyces pombe, respectively, by immunoblot analysis following sodium dodecyl sulfate-polyacryl-amide gel electrophoresis. Parts of the yeast recombinant EG IIIs decreased their molecular masses to 25 kDa after treatment with endoglycosidase H and alpha-mannosidase, suggesting that they are N glycosylated at least partly.
The human genome leads back to BC (2001)

When he was growing up on his parents' farm in Quesnel, BC, Marco Marra didn't plan on becoming a cutting-edge research scientist. Marra, the 34-year-old associate director of the Genome Sequence Centre at the British Columbia Cancer Agency, thought about working at the local lumber mill, but his
A role for ASIC3 in the modulation of high-intensity pain stimuli (2002)

Acid-sensing ion channel 3 (ASIC3), a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is expressed predominantly in sensory neurons including nociceptive neurons responding to protons. To study the role of ASIC3 in pain signaling, we generated ASIC3 knockout mice. Mutant animals were healthy and responded normally to most sensory stimuli. However, in behavioral assays for pain responses, ASIC3 null mutant mice displayed a reduced latency to the onset of pain responses, or more pain-related behaviors, when stimuli of moderate to high intensity were used. This unexpected effect seemed independent of the modality of the stimulus and was observed in the acetic acid-induced writhing test (0.6 vs. 0.1-0.5%), in the hot-plate test (52.5 and 55 vs. 50 degrees C), and in tests for mechanically induced pain (tail-pinch vs. von Frey filaments). We postulate that ASIC3 is involved in modulating moderate- to high-intensity pain sensation.
A 400&#x00B5;W differential FBAR sensor interface IC with digital readout (2015)

A low-power sensor interface IC suitable for a differential frequency measurement application is demonstrated. The circuit is used in a FBAR sensor system which includes a sensor and a reference FBAR. The sensor signal is processed and a digital output representing the sensor input is transmitted using a two wire serial interface. The architecture is entirely digital and benefits from scaling to advanced nodes. The IC is implemented in a 130nm CMOS process and consumes 400μW from a 0.75V supply.
Analysis of Human Genetic Linkage. (1992)

The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
Human T cell adhesion to endothelium stimulated by membrane components extracted from strains of Bacteroides vulgatus (member of B. fragilis group). (1993)

Bacteroides fragilis is reported to be less virulent than other Gram negative rods, existing in normal gut flora (e.g. Enterobacteriaceae). Lymphocytic infiltration, a typical finding in chronic infection, depends on cell extravasation and trafficking towards a site of antigen, a process that is regulated by endothelial expression of adhesion molecules. We have studied the ability of lipopolysaccharides and capsular polysaccharides of B. vulgatus group to induce human T cell adhesion to cultured endothelial cells. Both components of the bacterium caused markedly lesser T cell adhesion than LPS extracted from E. coli. Our data suggest that lower virulence of members of B. vulgatus group might be also dependent on its decreased ability to induce lymphocyte attachment to endothelium and subsequent tissue infiltration.
Densification involved in the UV-based photosensitivity of silica glasses and optical fibers (1997)

A comprehensive survey of photosensitivity in silica glasses and optical fiber is reviewed. Recent work on understanding the mechanisms contributing to germanium or aluminum doped fiber photosensitivity is discussed within the framework of photoelastic densification models.
Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology (2002)

Reduced sarcolemmal integrity in dystrophin-deficient muscles of mdx mice and Duchenne muscular dystrophy (DMD) patients has been reported to result in altered calcium homeostasis. Previous studies have shown a correlative relationship between calcium-dependent protease (calpain) activity in dystrophic muscle and muscle necrosis, but have not tested whether calpain activation precedes cell death or is a consequence of it. To test a causal relationship between calpain activation and muscle cell death in dystrophin deficiency, mdx mice were generated that overexpress a calpastatin transgene in muscle. Calpastatin (CS) is a specific, endogenous inhibitor of m- and micro -calpains that does not inhibit calpain 3 (p94). CS overexpression on a C57/BL 10 background produced no phenotype. Transgenic (Tg) mice crossed with mdx mice were tested for pathological indicators of necrosis, regeneration and membrane damage. Two lines of mice were examined, with different levels of CS overexpression. Both lines of Tg/mdx mice showed reductions in muscle necrosis at 4 weeks of age. These mice had fewer as well as smaller lesions. In addition, one line of mice had significantly less regeneration, indicating a reduction in previous necrosis. The extent of improvement correlated with the level of CS protein expression. Membrane damage, as assessed by procion orange and creatine kinase assays, was unchanged, supporting the idea that calpains act downstream of the primary muscle defect. These data suggest that calpains play an active role in necrotic processes in dystrophic muscle and that inhibition of calpains might provide a good therapeutic option for treatment of DMD.
A computational framework to study neural-structural interactions in human walking (2010)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.
Effect of Added Dietary Calcium on Colonic Epithelial-Cell Proliferation in Subjects at High Risk for Familial Colonic Cancer (1985)

We studied the frequency and distribution of proliferating epithelial cells lining colonic crypts in 10 subjects at high risk for familial colonic cancer, before and after oral supplementation of their conventional diets with 1.25 g of calcium as calcium carbonate. Patterns of cell proliferation were defined by dividing the colonic crypt into longitudinal compartments and comparing the numbers and fractions of tritiated thymidine--labeled epithelial cells in the various compartments. Before dietary supplementation with calcium, the profile of proliferating epithelial cells in the colonic crypts was comparable to that previously observed in subjects who had had familial colonic cancer. Two to three months after supplementation had been started, proliferation was significantly reduced and the profile of the colonic crypts approached that previously observed in subjects at low risk for colonic cancer. Our findings indicate that oral calcium supplementation induces a more quiescent equilibrium in epithelial-cell proliferation in the colonic mucosa of subjects at high risk of colon cancer, similar to that observed in subjects at low risk.
CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation (2007)

Regulatory T cells (T reg cells) are a population of CD4+ T cells that limit immune responses. FoxP3 is a master control transcription factor for development and function of these cells, but its regulation is poorly understood. We have identified a T cell receptor-responsive enhancer in the FoxP3 first intron that is dependent on a cyclic-AMP response element binding protein (CREB)/activating transcription factor (ATF) site overlapping a CpG island. Methylation of this island inversely correlates with CREB binding and FoxP3 expression. Interestingly, transforming growth factor-beta, which induces T reg cell formation, decreases methylation of the CpG island and increases FoxP3 expression. Similarly, inhibiting methylation with 5-azacytidine or knocking down the DNA methyltransferase Dnmt1 also induces FoxP3 expression. Conversely, methylation of the CpG island, which decreases CREB binding or expression of dominant-negative CREB, decreases FoxP3 gene expression. Thus, T cell receptor-induced FoxP3 expression in T reg cells is controlled both by sequence-specific binding of CREB/ATF and by DNA methylation of a CpG island.
Relational joins on graphics processors (2008)

We present a novel design and implementation of relational join algorithms for new-generation graphics processing units (GPUs). The most recent GPU features include support for writing to random memory locations, efficient inter-processor communication, and a programming model for general-purpose computing. Taking advantage of these new features, we design a set of data-parallel primitives such as split and sort, and use these primitives to implement indexed or non-indexed nested-loop, sort-merge and hash joins. Our algorithms utilize the high parallelism as well as the high memory bandwidth of the GPU, and use parallel computation and memory optimizations to effectively reduce memory stalls. We have implemented our algorithms on a PC with an NVIDIA G80 GPU and an Intel quad-core CPU. Our GPU-based join algorithms are able to achieve a performance improvement of 2-7X over their optimized CPU-based counterparts.
Heterocycles from Nitrile Oxides. Part V; 4-AminoΔ2-1,2,4-Oxadiazolines; Heterocycles (1989)

تتفاعل أكاسيد النيترايل مع هيدرازونات الكيتونات معطية أمينوأوكساديازولين، أكسدة هذه المركبات باستعمال مركبات خلات الرصاص الرباعية أدت لتكسرها لمركبات النيترايل والكيتون والنيتروجين.
A potent anti‐dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface (2014)

10.1002/emmm.201303404
Biology and Utilization of the Cucurbitaceae (1990)

The cucurbits (Cucurbitaceae, or gourd family), which include squash, pumpkin, melon, cucumber, and watermelon, have long been of economic significance. As sources of vegetables, fruit, and seeds rich in oils and protein, they have the potential of making an even larger contribution toward meeting the needs of humankind. This book, consisting of 37 papers by 50 cucurbit specialists, emphasizes the practical importance of cucurbit investigation, and also provides a broad overview of the family
Human comparative study of zinc and copper excretion via urine after administration of magnetic resonance imaging contrast agents. (2005)

Gd-DOTA was found to be the most kinetically inert among the three agents tested. The difference in zinc excretion among the MR contrast agents is possibly related to in-vivo transmetallation of the Gd chelate complexes correlated with variable stability of the contrast agents. The large amount of excess ligands contained in some MR contrast agents was also considered to be responsible for the increase of urinary zinc excretion.
Il rischio di tasso e il gap commerciale e finanziario: una verifica empirica per le banche italiane (2004)

La crisi economica dei primi anni novanta e il calo dei tassi di interesse hanno determinato per le banche una contrazione dei volumi intermediati ed una riduzione dei margini di guadagno. Nello stesso tempo l’aumento dell’efficienza dei mercati finanziari ha accresciuto l’attivita di negoziazione in valori mobiliari favorendo lo sviluppo di strumenti derivati. A cio si aggiunge la tendenza al consolidamento delle scadenze che ha interessato sia il lato attivo che quello passivo del bilancio. L’aumento della durata residua delle poste attive, -da ricercare sia nell’espansione del credito al consumo, sia in parte, nella parziale riduzione dell’indebitamento a breve delle imprese affidate- puo contribuire al consolidamento delle relazioni di clientela- consentendo di ottenere vantaggi informativi. L’aumento della durata residua del passivo e una costante strutturale del periodo 1989-1999 sia pur attuata avvalendosi di strumenti finanziari diversi: dai pronti contro termine, ai certificati di deposito e, da ultimo, alle obbligazioni particolarmente appetibili per limitare il calo di redditivita del portafoglio dei clienti, in una fase di tassi calanti. L’ampliamento del processo di trasformazione delle scadenze pone una duplice serie di problemi: da un lato puo causare tensione nella struttura finanziaria a livello di liquidita, dall’altro espone la banca al rischio di tasso. In questa prospettiva si colloca il presente lavoro il cui obiettivo e valutare l’esposizione al rischio di tasso per il periodo 1993-2001 del sistema bancario italiano, sia nel suo complesso sia in funzione delle classi dimensionali in cui e suddiviso. In particolare viene individuato il contributo delle poste fuori bilancio e delle operazioni indicizzate alla formazione della struttura per scadenze di tasso delle banche. Tale struttura consente la determinazione del gap incrementale ponderato. Per avere un quadro, il piu possibile disaggregato, delle variabili che influenzano tale grandezza si e proceduto a scindere idealmente l’unitaria gestione bancaria nella componente commerciale ed in quella finanziaria calcolando i rispettivi livelli di esposizione al rischio di tasso. L’evoluzione del gap incrementale ponderato con riferimento sia al complesso della operativita bancaria sia all’area commerciale e a quella finanziaria rappresenta il punto di partenza per valutare il ruolo giocato dalle poste a vista nella gestione del rischio di tasso.Da un punto di vista metodologico, e da sottolineare che si e scelto di basare tale valutazione su dati esclusivamente contabili. In tal modo si coglie solo una dimensione del rischio di tasso, quella reddituale, senza indagare l’impatto sul valore di mercato dei mezzi propri. La scelta e peraltro imposta dall’impossibilita di disporre di tutte le informazioni rilevanti per definire correttamente la duration delle attivita e delle passivita bancarie.
Connectables (2001)

We present the ConnecTable, a new mobile, networked and context-aware information appliance that provides affordances for pen-based individual and cooperative work as well as for the seamless transition between the two. In order to dynamically enlarge an interaction area for the purpose of shared use, a flexible coupling of displays has been realized that overcomes the restrictions of display sizes and borders. Two ConnecTable displays dynamically form a homogeneous display area when moved close to each other. The appropriate triggering signal comes from built-in sensors allowing users to temporally combine their individual displays to a larger shared one by a simple physical movement in space. Connected ConnecTables allow their users to work in parallel on an ad-hoc created shared workspace as well as exchanging information by simply shuffling objects from one display to the other. We discuss the user interface and related issues as well as the software architecture. We also present the physical realization of the ConnecTables.
IC for motion-compensated 100 Hz TV with smooth-motion movie-mode (2005)

An IC for consumer 100 Hz television is presented. It applies motion estimation and compensation techniques for very high-quality field rate up-conversion and a judder-free motion portrayal of movie material. The IC is fabricated with an 0.8 /spl mu/m CMOS process.
P‐202: High Transmittance Top Conductive Electrodes of OLEDs by Using Conductive Interface Layer (2020)

We report a conductive interface layer (CIL) in organic light emitting diodes configuration, which may optimize the poor contact between electron injection layers (EILs) and metal cathode. We also fabricated a transparent OLED device with top transparent conductive electrodes (tTCEs) whose transmittance exceeds 80% in both visible and near‐infrared ranges.
Phosphatidylserine on HIV Envelope Is a Cofactor for Infection of Monocytic Cells (2003)

HIV-1 is an enveloped retrovirus that acquires its outer membrane as the virion exits the cell. Because of the association of apoptosis with the progression of AIDS, HIV-1-infected T cells or macrophages might be expected to express elevated levels of surface phosphatidylserine (PS), a hallmark of programmed cell death. Virions produced by these cells would also be predicted to have PS on the surface of their envelopes. In this study, data are presented that support this hypothesis and suggest that PS is required for macrophage infection. The PS-specific protein annexin V was used to enrich for virus particles and to inhibit HIV-1 replication in primary macrophages, but not T cells. HIV-1 replication was also significantly inhibited with vesicles consisting of PS, but not phosphatidylcholine. PS is specifically required for HIV-1 infection because viruses pseudotyped with vesicular stomatitis virus G and amphotropic murine leukemia virus envelopes were not inhibited by PS vesicles or annexin V. These data indicate that PS is an important cofactor for HIV-1 infection of macrophages.
Cerebrospinal fluid shunt complications (1995)

Shunt malfunction and shunt infections are the most significant complications associated with cerebrospinal fluid shunts. Most cases of shunt infection are due to S. epidermidis or S. aureus. Seventy percent of all shunt infections present within two months of the shunt surgery. The most common factor associated with shunt infection is age under three months. Even fever may not be a consistent sign of shunt infection. A high index of suspicion for shunt infection or malfunction must be maintained when evaluating the patient with a cerebrospinal fluid shunt. There are many types of shunt systems in use today. An understanding of current shunt systems and their associated problems should allow physicians to promptly diagnose and initiate treatment for patients with cerebrospinal fluid shunts. Prompt neurosurgical consultation is mandatory whenever shunt malfunction or infection is suspected.