gebhart/patrepeval huggingface dataset:
Normal Serum Relaxin in Women with Disabling Pelvic Pain during Pregnancy (1994)

As part of a case control within cohort study 472 pregnant women answered a questionnaire post partum. Serum relaxin concentrations were measured by a homologous ELISA in samples collected from the women in the 30th week of pregnancy. Serum relaxin concentrations were not associated with pregnancy-associated pelvic pain. Thus, normal pregnant women without pelvic pain (n = 118) had mean concentrations of 343 pg/ml compared to 332 pg/ml in women (n = 59) with pelvic pain and some restriction in daily activities and to 349 pg/ml in women (n = 9) with severe pregnancy-induced pelvic pain. The present results do not suggest a role for relaxin in symptom-giving pelvic relaxation during human pregnancy.
Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons (2004)

Embryonic stem (ES) cells have many of the characteristics of an optimal cell source for cell-replacement therapy. Although the usefulness of the in vitro generation of dopamine (DA)-neural precursors from ES cells has been widely discussed, functional recovery in animal models of Parkinson's disease is not fully understood. In 6-hydroxydopamine-lesioned rats, apomorphine markedly induced contralateral rotation. Apomorphine-induced rotation was significantly reduced by transplantation of neuron-like cells that had differentiated from mouse ES cells using nicotinamide, but not L-lysine. In addition, methamphetamine-induced ipsilateral rotation was significantly reduced. On the other hand, picrotoxin did not inhibit apomorphine-induced rotational asymmetry. Fluoxetine alone and fenfluramine alone induced slight contralateral rotation and rotation in both directions, respectively, and these effects were similar in transplanted rats. Although immunoreactivity for tyrosine hydroxylase (TH) was almost completely lost in the ipsilateral striatum in hemiparkinsonian rats, TH immunoreactivity was detected in transplanted cells and sprouting fibers. In contrast, immunoreactivities for gamma-aminobutyric acid (GABA) and serotonin (5-HT) neurons were not changed. These results suggest that improvement of rotational behavior may be induced predominantly by transplantation of nicotinamide-treated ES cell-derived DA neurons, rather than by changes in the activities of GABA or 5-HT neural systems, in hemiparkinsonian rats.
Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast (2001)

Genome integrity is monitored by a checkpoint that delays mitosis in response to DNA damage. This checkpoint is enforced by Chk1, a protein kinase that inhibits the mitotic inducer Cdc25. In fission yeast, Chk1 is regulated by a group of proteins that includes Rad3, a protein kinase related to human ATM and ATR. These kinases phosphorylate serine or threonine followed by glutamine (SQ/TQ). Fission yeast and human Chk1 proteins share two conserved SQ motifs at serine-345 and serine-367. Serine-345 of human Chk1 is phosphorylated in response to DNA damage. Here we report that Rad3 and ATM phosphorylate serine-345 of fission yeast Chk1. Mutation of serine-345 (chk1-S345A) abrogates Rad3-dependent phosphorylation of Chk1 in vivo. The chk1-S345A cells are sensitive to DNA damage and are checkpoint defective. In contrast, mutations of serine-367 and other SQ/TQ sites do not substantially impair the checkpoint or cause damage sensitivity. These findings attest to the importance of serine-345 phosphorylation for Chk1 function and strengthen evidence that transduction of the DNA damage checkpoint signal requires direct phosphorylation of Chk1 by Rad3.
Information retrieval and spelling correction (2002)

In a preliminary study, we show the effect of spelling errors on an ad hoc information retrieval task. Then, we report on the comparison of different strategies for correcting spelling errors resulting in non-existent words. Unlike interactive spelling checkers, where usually only the left context is available, the system we developed takes advantage of the entire context surrounding misspelling. Moreover, unlike traditional systems, based exclusively on a string-to-string edit distance and a word language model, we explore the use of the part-of-speech for selecting candidates. In conclusion, we show that spelling correction improves by extending the context. The best results are obtained when combining a part-of-speech filter with a word language model, and using both the left and right adjacent contexts.
Detection and quantitation of circulating cancer cells in the peripheral blood of lung cancer patients. (1998)

Detection and quantitation of circulating cancer cells in peripheral blood may improve cancer staging and monitoring. This study explored the feasibility of using circulating cancer cell detection in peripheral blood for the rapid assessment of chemotherapeutic response. Cytokeratin 19 mRNA was amplified by nested reverse transcriptase-PCR in the peripheral blood of 29 healthy volunteers, 33 pneumonia patients, and 86 lung cancer patients. Circulating cancer cells in the peripheral blood were semiquantitatively determined by taking the ratio of cytokeratin 19 band intensity from the second round of nested PCR to the glyceraldehyde-3-phosphate dehydrogenase band intensity from the first round of PCR amplification. The detection limit of the method was 1 cancer cell in 107 peripheral blood mononuclear cells. The positive detection rate was 40% for lung adenocarcinoma patients of all stages, 41% for squamous carcinoma patients of all stages, and 27% for small cell lung cancer patients. Only one control sample from a pneumonia patient showed a positive result (1.6%). The quantitative method reliably and sensitively estimated cancer cell numbers in the peripheral blood of lung cancer patients. Serial measurement of the relative number of circulating cancer cells correlated with the tumor burden and treatment response of patients. This method may help rapidly assess the efficacy of anticancer treatment, redefine cancer staging, and facilitate the design of better therapeutic strategies for the treatment of cancer patients.
Retinoic Acid Induces Aggregation of the Acute Promyelocytic Leukemia Cell Line NB-4 by Utilization of LFA-1 and ICAM-2 (1997)

All-trans retinoic acid (tRA) is a potent differentiation agent that is effective therapy for acute promyelocytic leukemia (APL). However, 5% to 25% of patients develop retinoic acid syndrome, a potentially life-threatening complication in which the pathogenesis relates to adhesive alterations of APL cells. Therefore, we investigated the relationship between tRA-induced differentiation and the adhesive properties of APL cells. After confirming differentiation-related morphological changes of NB-4 cells in response to tRA, we showed that homotypic aggregation of NB-4 cells grown in tRA for 72 hours is dose-dependent with a median effective dose of approximately 50 nmol/L. Maximal aggregation occurred at mean and peak therapeutic serum concentrations (100 and 1,000 nmol/L, respectively). Aggregation also increased with the length of tRA exposure over 168 hours. Aggregation was inhibited by neutralizing antibodies against LFA-1 and ICAM-2. Notably, antibodies directed against VLA-4, other beta2 integrins (Mac-1 and p150), or other potential LFA-1 counterstructures that were expressed on the cell surface (ICAM-1 and ICAM-3) did not block aggregation. Aggregation occurred with similar kinetics regardless of the presence of phorbol ester or the "activating" monoclonal antibody (MoAb) KIM 185, suggesting that the avidity of LFA-1 is not modulated on NB-4 cells in a manner similar to other leukocytes. Consistent with the prompt clinical effectiveness of methyl prednisolone sodium succinate (MPSS) in retinoic acid syndrome, MPSS rapidly inhibited homotypic aggregation in a dose-dependent manner. Thus, tRA alters the adhesive properties of APL cells by inducing the expression of high-avidity beta2 integrins, aggregation is inhibited by LFA-1 and ICAM-2 MoAb, and tRA effects are rapidly reversible by MPSS. Taken together, our findings provide a clinically relevant system for study of LFA-1/ICAM-2 interaction and suggest a mechanism in part for retinoic acid syndrome and the effectiveness of MPSS in ameliorating retinoic acid syndrome.
Successive interference cancellation for cdma2000 using a software defined radio (2006)

Signal strength imbalance due to imperfect power control and soft handoffs in direct-sequence code division multiple access (CDMA) cellular systems increases the mutual interference among users. This paper discusses the use of successive interference cancellation (SIC) for improving the reception of reverse link signals transmitted by cdma2000 mobile stations. A single-stage SIC algorithm has been implemented in a software defined radio (SDR) which employs general purpose digital signal processing (DSP) chips for interference cancellation and signal demodulation. Computer simulation of the DSP software and measured performance of the SDR have shown SIC to be an effective multiuser detector for the cdma2000 reverse link
Kernelized locality-sensitive hashing for scalable image search (2009)

Fast retrieval methods are critical for large-scale and data-driven vision applications. Recent work has explored ways to embed high-dimensional features or complex distance functions into a low-dimensional Hamming space where items can be efficiently searched. However, existing methods do not apply for high-dimensional kernelized data when the underlying feature embedding for the kernel is unknown. We show how to generalize locality-sensitive hashing to accommodate arbitrary kernel functions, making it possible to preserve the algorithm's sub-linear time similarity search guarantees for a wide class of useful similarity functions. Since a number of successful image-based kernels have unknown or incomputable embeddings, this is especially valuable for image retrieval tasks. We validate our technique on several large-scale datasets, and show that it enables accurate and fast performance for example-based object classification, feature matching, and content-based retrieval.
Simple Synthesis of KDO α‐Glycosides by Anomerically Selective O‐Alkylation (1988)

Oligosaccharides with the α(2–6′)-bound oxodeoxysugar KDO play an exceptionally large role as components of lipopolysacharides. The synthesis of such KDO-α-glycosides has now been accomplished in high yields with the key adduct 1. The trick is the reaction with NaH resulting in double deprotonation to a chelate in which the α-configuration is “fixed”.
New Reactive Coenzyme Analogues for Affinity Labeling of NAD+ and NADP+ Dependent Dehydrogenases (1995)

Reactive coenzyme analogues omega-(3-diazoniumpyridinium)alkyl adenosine diphosphate were prepared by reaction of omega-(3-aminopyridinium)alkyl adenosine diphosphate with nitrous acid. In these compounds the nicotinamide ribose is substituted by hydrocarbon chains of varied lengths (n-ethyl to n-pentyl). The diazonium compounds are very unstable and decompose rapidly at room temperature. They show a better stability to 0 degree C. Lactate and alcohol dehydrogenase do not react with any of the analogues. Glyceraldehyde-3-phosphate dehydrogenase reacts rapidly with the diazoniumpentyl compound. Decreasing the length of the alkyl chain significantly decreases the inactivation velocity. 3 alpha, 20 beta-Hydroxysteroid dehydrogenase reacts at 0 degree C with the ethyl homologue and slowly with the propyl compound. The butyl- and pentyl analogues do not inactivate at 0 degree C. Tests with 14C-labeled 2-(3-diazoniumpyridinium)ethyl adenosine diphosphate show that complete loss of enzyme activity results after incorporation of 2 moles of inactivator into 1 mole of tetrameric enzyme. 4-(3-Acetylpyridinium)butyl 2'-phospho-adenosine diphosphate, a structural analogue of NADP+, was prepared by condensation of adenosine-2,3-cyclophospho-5'-phosphomorpholidate with (3-acetylpyridinium)butyl phosphate, followed by hydrolysis of the cyclic phosphoric acid with 2':3'-cyclonucleotide-3'-phosphodiesterase. Because of the redox potential (-315 mV) and the distance between the pyridinium and phosphate groups, this analogue is a hydrogen acceptor and its reduced form a hydrogen donor in tests with alcohol dehydrogenase from Thermoanaerobium brockii. The reduced form of the coenzyme analogue also is a hydrogen donor with glutathione reductase. With other NADP+-dependent dehydrogenases the compound has been shown to be a competitive inhibitor against the natural coenzyme. The acetyl group reacts with bromine to form the bromoacetyl group. This reactive bromoacetyl analogue is a specific active-site directed irreversible inhibitor of isocitrate dehydrogenase.
Anticoagulants and blood thinners during cutaneous surgery: always, sometimes or never? (2004)

There is no consensus with regard to perioperative blood thinner management in patients undergoing cutaneous procedures. The rationale and problems associated with blood thinners during cutaneous surgery are examined and the preoperative screening and surgical management of patients taking anticoagulant medicines discussed. There are many studies that support continuation of blood thinners during cutaneous procedures supporting the conclusion that blood thinners should not be discontinued for cutaneous procedures.
Increased inflammatory status and higher prevalence of three-vessel coronary artery disease in patients with concomitant coronary and peripheral atherosclerosis (2003)

The aim of this study was to determine whether patients with coronary artery disease (CAD) and concomitant peripheral arterial disease (PAD) have a greater inflammatory status than those with CAD alone. To this aim, we evaluated PAD (ankle/brachial pressure index <0.9), and measured plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in 234 patients who underwent coronary angiography. Median levels of CRP, IL-6 and sICAM-1 were higher in the CAD without PAD (n=134) and CAD+PAD (n=40) groups than in 60 patients without either disease ("controls"). Median CRP values were higher in patients with CAD+PAD than in patients with CAD alone (4.7 mg/L [1.5; 7.6] vs 2.4 mg/L [0.9; 3.8], p < 0.01).Three-vessel CAD was diagnosed in 60% of CAD+PAD patients and in 21% (p< 0.01) of CAD only patients. After adjustment for confounding factors, only PAD was independently associated with three-vessel CAD (p<0.001). This association was maintained after adjustment for IL-6, the only inflammatory parameter significantly associated with three-vessel CAD at univariate analysis (p<0.01). In conclusion, in CAD the coexistence of PAD is associated with a greater inflammatory status and more widespread coronary atherosclerosis. These results could help to explain the high cardiovascular risk of patients with concomitant CAD and PAD and suggest that PAD be included among the variables used to identify CAD patients for further diagnostic evaluation.
Degradation of Green Tea Catechins in Tea Drinks (2000)

Green tea cateachins (GTC). namely (-) epicatechin (EC), (-) epicatechin gallate (ECG), (-) epigallocatechin (EGC), and (-) epigallocatechin gallate (EGCG), have been studied extensively for their wide-ranging biological activities. The goal of the present study was to examine the stability of GTC as a mixture under various processing conditions. The stability study demonstrated that GTC was stable in water at room temperature. When it was brewed at 98 degrees C for 7 h, longjing GTC degraded by 20%. When longjing GTC and pure EGCG were autoclaved at 120 degrees C for 20 min, the epimerization of EGCG to (-) gallocatechin gallate (GCG) was observed. The relatively high amount of GCG found in some tea drinks was most likely the epimerization product of EGCG during autoclaving. If other ingredients were absent, the GTC in aqueous solutions was pH-sensitive: the lower the pH, the more stable the GTC during storage. When it was added into commercially available soft drinks or sucrose solutions containing citric acid and ascorbic acid, longjing GTC exhibited varying stability irrespective of low pH value. This suggested that other ingredients used in production of tea drinks might interact with GTC and affect its stability. When canned and bottled tea drinks are produced, stored, and transported, the degradation of GTC must be taken into consideration.
Molecular Interaction of Proteins and Peptides with Nanoparticles (2012)

International audience
On Venustas A Semantic Inquiry into the Notion of Beauty (2010)

Along with Firmitas and Utilitas, the concept of Venustas is one of three important principles in the Vitruvian Triad that Marcus Vitruvius Polio introduced in The Ten Books of Architecture. Known today as strength, use and beauty, the triad had been a guiding principle in both architectural theory and practice since antiquity. Yet, however important, the concept of beauty is oftentimes elusive. How do we defi ne, understand and refer to it? Where does it come from? This paper argues that the concept of Venustas does not signify only the beautiful, but is a complex concept that represents the many facets of human lives and desires, both beauty and sublime, good and bad, love and hate, admiration and fear. It is a concept that is best viewed through an understanding of different modes of opposition in the philosophy and myths of antiquity. This paper attempts to unfold the very nature of beauty, how the ideas originated, how the various visions of beauty have come into being. The paper is thus a study of the concept of beauty within the framework of polarity and unity through the myths of Venus, the goddess. Starting from early Greek philosophy, the paper will continue its investigation in the Renaissance notion of beauty in relation to the myths of antiquity, as well as in the 18th century’s vision of beauty through the work of Edmund Burke, A Philosophical Enquiry into the Origin of Our Idea of the Sublime and Beautiful (1757), and will conclude with the notion of Concinnitas,which according to Leon Battista Alberti, is the matter that springs from the rule of beauty. Through such studies, the paper is hoped to introduce different visions and open new possible views towards the notion of beauty. ตนขาว ปาณนท Assistant Professor, Faculty of Architecture, Silpakorn University. บทความนเปนการศกษาทฤษฎและแนวความคดเกยวกบ Venustas หรอความงาม ซงเปนหลกสำคญประการหนงในหลกสำคญสามประการหรอท Marcus Pollio Vitruvius นำเสนอในตำราทฤษฎ The Ten Books of Architecture ซงประกอบไปดวยความแขงแรงคงทน หรอ Firmitas, การใชสอยหรอ Utilitas และความงามหรอ Venustas บทความนเรมตนจากสมมตฐานทวาแนวความคดเกยวกบ Venustas นนมไดหมายถงความงดงามเพยงอยางเดยว แตมความหมายทซบซอนเกยวเนองกบความขดแยงและความสมพนธตางๆในการดำเนนชวตของมนษย การศกษาทฤษฎและหลกการเกยวกบความงามในบทความนจะเปนการศกษาผานปรชญาและความเชอในยคกรกโบราณ ซงเปนจดกำเนดของศพทคำวา Venustas และเปนการศกษาการเปลยนแปลงของแนวความคดเกยวกบความงามในยค Renaissance จนถงชวงศตวรรษท 18 โดยมวตถประสงคเพอคนหาทมาของความหมาย ความสมพนธและนยทางสถาปตยกรรมของคำวา Venustas.
Settle: An analytical version of the SHAKE and RATTLE algorithm for rigid water models (1992)

Abstract An analytical algorithm, called SETTLE, for resetting the positions and velocities to satisfy the holonomic constraints on the rigid water model is presented. This method is still based on the Cartesian coordinate system and can be used in place of SHAKE and RATTLE. We implemented this algorithm in the SPASMS package of molecular mechanics and dynamics. Several series of molecular dynamics simulations were carried out to examine the performance of the new algorithm in comparison with the original RATTLE method. It was found that SETTLE is of higher accuracy and is faster than RATTLE with reasonable tolerances by three to nine times on a scalar machine. Furthermore, the performance improvement ranged from factors of 26 to 98 on a vector machine since the method presented is not iterative. © 1992 by John Wiley &amp; Sons, Inc.
Detection of Apoptotic Fetal Cells in Plasma of Pregnant Women (2000)

setting where TMS is used for several assays, as is the case in other laboratories (6 ), it makes economic sense to consolidate to one platform that can perform multiple assays without operator intervention.
Cloning and characterization of the C.elegans histidyl-tRNA synthetase gene (1993)

In this paper, we report the cloning and sequencing of the C. elegans histidyl-tRNA synthetase gene. The complete genomic sequence, and most of the cDNA sequence, of this gene is now determined. The gene size including flanking and coding regions is 2230 nucleotides long. Three small introns (45-50 bp long) are found to interrupt the open reading frame. The open reading frame translates to 523 amino acids. This putative protein sequence shows extensive homology with the human and yeast histidyl-tRNA the histidyl-tRNA synthetase gene is a single copy gene. Hence, it is very likely that it encodes both the cytoplasmic and the mitochondrial histidyl-tRNA synthetases. It is likely to be trans-spliced since it contains a trans-splice site in its 5' untranslated region.
Biofilms in Food Processing Environments (1998)

Biofilms are a constant concern in food processing environments. Our overall research focus has been to understand the interaction of factors affecting bacterial attachment and biofilm formation with the ultimate goal of devising strategies to control this problem. This paper briefly describes three areas of biofilm research in which we have been involved. Listeria monocytogenes, a foodborne pathogen, survived for prolonged periods on stainless steel and buna-n rubber, materials commonly used in food-processing equipment. Survival was affected by temperature, relative humidity, attachment surface, and soil. Some components in the rubber inhibited growth of the organism on buna-n, which also affected the efficacy of sanitizers on biofilm inactivation. In cheese manufacture, biofilms of Lactobacillus curvatus could lead to a defect caused by the formation of calcium lactate crystals in Cheddar cheese. This hardy organism persisted in low numbers on equipment surfaces and was difficult to eradicate. We investigated the relative contributions and interactions of mechanical, thermal, and chemical processes in an air-injected clean-in-place method for milking systems. Overall, it is important to study the interactions between bacteria and the surfaces in a specific food processing environment to provide more effective measures for prevention of biofilm formation and for its removal.