gebhart/patrepeval huggingface dataset:
Regulation of Interleukin-8 Expression by Nitric Oxide in Human Pancreatic Adenocarcinoma (2001)

The regulation of interleukin-8 (IL-8) expression by nitric oxide (NO) was determined in human pancreatic cancer cell lines. CaPan-2 and FG human pancreatic adenocarcinoma cells were incubated for 24 h in medium alone or medium containing a cytokine mixture in the presence or absence of an NO synthase (NOS) inhibitor, N(G)-monomethyl-L-arginine (NMA). The NOS activity and level of IL-8 expression were determined. IL-8 expression was induced in the two cell lines. A low level of NOS activity was detectable only in CaPan-2 cells. Moreover, the presence of NMA did not reverse the induction of IL-8. The FG cells were then engineered to produce a physiologic level of NO and incubated in medium alone or medium containing 1 mM NMA. No significant IL-8 expression was induced in those producing a low level of NO, whereas IL-8 expression was induced in those producing a high level of NO. Inhibition of NO production by NMA reversed this effect. Incubation of FG cells with an NO donor, S-nitroso-D,L.-acetyl-penicillamine (SNAP), led to a concentration-dependent and time-dependent induction of IL-8 expression. This NO-mediated upregulation of IL-8 expression correlated with an increase in IL-8 gene transcription and mRNA stability. Our results indicate that NO is involved in the regulation of IL-8 expression in and contributes to the progression of human pancreatic cancer.
Analysis of improvement to two-wheel robot navigation using low-cost GPS/INS aids (2006)

This paper shows the use of sensor fusion (GPS/INS/odometry) to estimate and eliminate errors which are unobservable for a two-wheeled robot using odometry information alone, including the accuracy benefit that combinations of these sensors provide. The combinations examined are GPS/odometry and INS/odometry, both of which are low-cost options. It is shown that the effects of longitudinal wheel slip and tire radius error can be lumped together as an ‘effective radius’ and estimated effectively using GPS velocity and course measurements. This estimated radius can account for these error modes at the speed at which it was estimated but the estimation effectiveness degrades as speed changes. This paper shows the improvement to the navigation of a two-wheel robot platform using this estimation method.
Full-Resolution Residual Networks for Semantic Segmentation in Street Scenes (2017)

Semantic image segmentation is an essential component of modern autonomous driving systems, as an accurate understanding of the surrounding scene is crucial to navigation and action planning. Current state-of-the-art approaches in semantic image segmentation rely on pre-trained networks that were initially developed for classifying images as a whole. While these networks exhibit outstanding recognition performance (i.e., what is visible?), they lack localization accuracy (i.e., where precisely is something located?). Therefore, additional processing steps have to be performed in order to obtain pixel-accurate segmentation masks at the full image resolution. To alleviate this problem we propose a novel ResNet-like architecture that exhibits strong localization and recognition performance. We combine multi-scale context with pixel-level accuracy by using two processing streams within our network: One stream carries information at the full image resolution, enabling precise adherence to segment boundaries. The other stream undergoes a sequence of pooling operations to obtain robust features for recognition. The two streams are coupled at the full image resolution using residuals. Without additional processing steps and without pre-training, our approach achieves an intersection-over-union score of 71.8% on the Cityscapes dataset.
Transgenic birds from transformed primordial germ cells (1993)

Primordial germ cells (PGCS) are the progenitor cells for the gametes. They can be obtained from avian embryos by dissociating the germinal crescent region, where they accumulate, or by sampling the blood at the time of their migration to the gonad. PGCS were obtained from these sources and transfected with defective retroviruses. These manipulated cells were injected into recipient embryos to form chimaeras which grew to sexual maturity and produced offspring, some of which contained the foreign DNA. This is the first example of the direct use of PGCS to produce transgenic offspring.
Mitogenic lectins bind to the antigen receptor on human lymphocytes (1989)

The specificity of interactions between mitogenic and non-mitogenic lectins and disulfide-linked cell surface receptors on human lymphocytes was explored. Lysates (Nonidet-P40) of surface-radioiodinated tonsil lymphocytes and T lymphoblastoid cells (HPB-ALL) were absorbed with lectin-agarose derivatives (or bovine serum albumin, BSA-agarose) or immunoprecipitated with appropriate monoclonal antibodies (mAb). Lectin eluates and solubilized immunoprecipitates were analyzed by two-dimensional (nonreduced/reduced) sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Radiolabeled polypeptides were visualized by autoradiography. Among the various lectin-binding polypeptides, two disulfide-linked heterodimers (II and III) and two apparent homodimers (I and IV) are bound by pea lectin, concanavalin A and lentil lectin on tonsil lymphocytes; II, III and IV are bound both leukoagglutinating (L)- and erythroagglutinating (E)-phytohemagglutinins from Phaseolus vulgaris (PHA). Pokeweed mitogen recognizes only II and III. These molecules are weakly bound by peanut agglutinin, soybean agglutinin, Ulex europaeus agglutinin-I, Dolichos biflorus agglutinin, Vicia villosa agglutinin and Sophora japonica agglutinin, but are not bound by Helix pomatia agglutinin or BSA-agarose. Heterodimer II (82-88 kDa), comprised of 50-55-kDa and 40-43-kDa subunits, probably represents the alpha/beta T cell antigen receptor (TcR alpha/beta). Heterodimer III (64-72 kDa), comprised of 41-kDa and 37-kDa subunits, may represent TcR gamma. The homodimers, I (120-130 kDa) and IV (55-61 kDa), comprised of 55-60-kDa and 30-kDa polypeptides, respectively, have apparently not been previously described. Evidence that H1-2D4, a mAb directed against the antigen receptor on HPB-ALL cells, and E-PHA interact with a common molecule includes: (a) immunoprecipitation of TcR with H1-2D4 from the glycopeptide fraction specifically eluted from insolubilized lectin with N-acetylgalactosamine; and (b) adsorption of TcR from a solubilized H1-2D4 immunoprecipitate by E-PHA-agarose. Recognition of CD3 by E-PHA is indicated by immunoprecipitation of CD3 protein by UCHT1 from the glycopeptide fraction specifically eluted from E-PHA. The results are consistent with the view that mitogenic lectins interact with certain disulfide-linked molecules on human lymphocytes, including the TcR alpha/beta and perhaps TcR gamma; while some nonmitogenic lectins also recognize these receptors, the interaction is of low affinity.
Optimal aggregation algorithms for middleware (2001)

Assume that each object in a database has m grades, or scores, one for each of m attributes. For example, an object can have a color grade, that tells how red it is, and a shape grade, that tells how round it is. For each attribute, there is a sorted list, which lists each object and its grade under that attribute, sorted by grade (highest grade first). There is some monotone aggregation function, or combining rule, such as min or average, that combines the individual grades to obtain an overall grade.
Four Major Envelope Proteins of White Spot Syndrome Virus Bind To Form a Complex (2009)

Early events in white spot syndrome virus (WSSV) morphogenesis, particularly the formation of viral membranes, are poorly understood. The major envelope proteins of WSSV are VP28, VP26, VP24, and VP19. Our previous results indicated that VP28 interacts with VP26 and VP24. In the present study, we used coimmunoprecipitation assays and pull-down assays to confirm that the four major proteins in the WSSV envelope can form a multiprotein complex. Yeast two-hybrid assays were also used to test for interactions among the four proteins. In summary, three pairwise protein interactions (VP19-VP28, VP19-VP24, and VP24-VP26) and one self-association (VP24-VP24) were identified for the first time.
Comparative Analysis of Physical Maps of FourBacillus subtilis(natto) Genomes (2004)

The complete SfiI and I-CeuI physical maps of four Bacillus subtilis (natto) strains, which were previously isolated as natto (fermented soybean) starters, were constructed to elucidate the genome structure. Not only the similarity in genome size and organization but also the microheterogeneity of the gene context was revealed. No large-scale genome rearrangements among the four strains were indicated by mapping of the genes, including 10 rRNA operons (rrn) and relevant genes required for natto production, to the loci corresponding to those of the B. subtilis strain Marburg 168. However, restriction fragment length polymorphism and the presence or absence of strain-specific DNA sequences, such as the prophages SP beta, skin element, and PBSX, as well as the insertion element IS4Bsu1, could be used to identify one of these strains as a Marburg type and the other three strains as natto types. The genome structure and gene heterogeneity were also consistent with the type of indigenous plasmids harbored by the strains.
Photonic Band Structures (1994)

Abstract Building complex materials with structures on a scale comparable to the wavelength of light offers possibilities for radically changing the way light moves around such materials, in the same way that we engineer atomic structure to vary electronic properties of semiconductors. In this paper we describe in detail how to make numerical calculations of the dispersion relations (the band structure) of these complex objects, and how to calculate transmission through, and reflection from them. Finally these methodologies are applied to a colloidal dispersion of metallic particles at 12% volume filling fraction to reproduce the well known characteristics of strong optical absorption.
Large-signal modeling of microwave gallium nitride-based HFETs (2002)

This paper describes the large-signal model of the heterojunction field-effect transistors (HFET) based on Al/sub x/Ga/sub 1-x/N/GaN heterostructure used as control components for high-power microwave and RF control devices (switches, attenuators, phase-shifters, etc.). Its use should extend power level of FET-based RF and microwave.
Statistical Theories of Mental Test Scores (1969)

This is a reprint of the orginal book released in 1968. Our primary goal in this book is to sharpen the skill, sophistication, and in- tuition of the reader in the interpretation of mental test data, and in the construction and use of mental tests both as instruments of psychological theory and as tools in the practical problems of selection, evaluation, and guidance. We seek to do this by exposing the reader to some psychologically meaningful statistical theories of mental test scores. Although this book is organized in terms of test-score theories and models, the practical applications and limitations of each model studied receive substantial emphasis, and these discussions are presented in as nontechnical a manner as we have found possible. Since this book catalogues a host of test theory models and formulas, it may serve as a reference handbook. Also, for a limited group of specialists, this book aims to provide a more rigorous foundation for further theoretical research than has heretofore been available.One aim of this book is to present statements of the assumptions, together with derivations of the implications, of a selected group of statistical models that the authors believe to be useful as guides in the practices of test construction and utilization. With few exceptions we have given a complete proof for each major result presented in the book. In many cases these proofs are simpler, more complete, and more illuminating than those originally offered. When we have omitted proofs or parts of proofs, we have generally provided a reference containing the omitted argument. We have left some proofs as exercises for the reader, but only when the general method of proof has already been demonstrated. At times we have proved only special cases of more generally stated theorems, when the general proof affords no additional insight into the problem and yet is substantially more complex mathematically.
Catheter-directed Gastric Artery Chemical Embolization Suppresses Systemic Ghrelin Levels in Porcine Model (2008)

Catheter-directed GACE can suppress the appetite hormone ghrelin and affect weight gain.
A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections (2008)

The objective of this review is to describe the current status of several intravaginal anti-HIV microbicidal delivery systems these delivery systems and microbicidal compounds in the context of their stage within clinical trials and their potential cervicovaginal defence successes. The global Human Immuno-Deficiency Virus (HIV) pandemic continues to spread at a rate of more than 15,000 new infections daily and sexually transmitted infections (STIs) can predispose people to acquiring HIV infection. Male-to-female transmission is eight times more likely to occur than female-to-male transmission due to the anatomical structure of the vagina as well as socio-economic factors and the disempowerment of women that renders them unable to refuse unsafe sexual practices in some communities. The increased incidence of HIV in women has identified the urgent need for efficacious and safe intravaginal delivery of anti-HIV agents that can be used and controlled by women. To meet this challenge, several intravaginal anti-HIV microbicidal delivery systems are in the process of been developed. The outcomes of three main categories are discussed in this review: namely, dual-function polymeric systems, non-polymeric systems and nanotechnology-based systems. These delivery systems include formulations that modify the genital environment (e.g. polyacrylic acid gels and lactobacillus gels), surfactants (e.g. sodium lauryl sulfate), polyanionic therapeutic polymers (e.g. carageenan and carbomer/lactic acid gels), proteins (e.g. cyanovirin-N, monoclonal antibodies and thromspondin-1 peptides), protease inhibitors and other molecules (e.g. dendrimer based-gels and the molecular condom). Intravaginal microbicide delivery systems are providing a new option for preventing the transmission of STIs and HIV.
Fusarium toxins in field corn. I. Time course of fungal growth and production of deoxynivalenol and other mycotoxins (1983)

The formation of the trichothecene mycotoxins deoxynivalenol and 15-acetyldeoxynivalenol and zearalenone in field corn inoculated with Fusarium graminearum was studied over a growing season. The mycotoxins, ergosterol, colony forming units, weight, moisture, and ash contents were measured in the infected ears. Measurements of toxins and ergosterol in infected plants, weather data, and analyses of the soil mycoflora were also taken. In the infected ears, fungal propagule counts rapidly increased up to 6 weeks after inoculation and then sharply declined. Ergosterol concentrations followed the propagule data for the first 6 weeks and then levelled off (at about 70 ppm). Deoxynivalenol concentrations increased (to about 580 ppm), over the same period and then declined (to about 430 ppm); 15-acetyldeoxynivalenol concentrations rose rapidly in the first 2 weeks (to 64 ppm) and then slowly declined (to 20 ppm); an appreciable amount of zearalenone (10 ppm) was not observed until 9 weeks after inoculation. The data indicated that the relative and absolute concentrations of the two trichothecenes present in the corn may have been affected by the plant, and toxins were found throughout the plant but mainly in the infected part.
Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, α-phellandrene, and essential oil fromSchinus terebinthifoliusfruits in a neuropathic pain model (2014)

Together, the results of the present work show that essential oil of S. terebinthifolius and compounds present in this oil, including (R)-(+)-limonene and α-phellandrene, exhibit antihyperalgesic effects against mechanical hyperalgesia, and are antidepressive, while only α-phellandrene inhibited cold hyperalgesia in SNI rats.
Automated processing of human bone marrow can result in a population of mononuclear cells capable of achieving engraftment following transplantation (1991)

A concentrate of mononuclear bone marrow cells is often desired for ex vivo treatment with pharmacologic agents, monoclonal antibodies, cytokines, and other agents prior to transplantation. A method has been developed for automated separation of mononuclear cells from large volumes of harvested bone marrow. A programmable instrument originally designed for clinical ex vivo cell separation and the plasma-pheresis of patients and blood donors was adapted to permit rapid preparation, in a closed sterile system, of a bone marrow product enriched with mononuclear cells. A mean (+/- SEM) of 53 +/- 30 percent of the original mononuclear cells was recovered in a volume of 125 +/- 42 mL containing 82 +/- 12 percent mononuclear cells. This technique removed 95 +/- 9 percent of the red cells in the original marrow. No density gradient materials or sedimenting agents were employed in this process. Of 36 marrows processed by this technique, 19 autologous (6 of which were purged with 4-hydroperoxycyclophosphamide) and 7 allogeneic marrows have been transplanted, with all evaluable patients achieving a neutrophil count of 0.5 x 10(9) per L in a mean (+/- SEM) of 21 +/- 6 days.
Efficient elasticity for character skinning with contact and collisions (2011)

We present a new algorithm for near-interactive simulation of skeleton driven, high resolution elasticity models. Our methodology is used for soft tissue deformation in character animation. The algorithm is based on a novel discretization of corotational elasticity over a hexahedral lattice. Within this framework we enforce positive definiteness of the stiffness matrix to allow efficient quasistatics and dynamics. In addition, we present a multigrid method that converges with very high efficiency. Our design targets performance through parallelism using a fully vectorized and branch-free SVD algorithm as well as a stable one-point quadrature scheme. Since body collisions, self collisions and soft-constraints are necessary for real-world examples, we present a simple framework for enforcing them. The whole approach is demonstrated in an end-to-end production-level character skinning system.
Suppression of Granulocyte-Macrophage Colony-Stimulating Factor Expression by Glucocorticoids Involves Inhibition of Enhancer Function by the Glucocorticoid Receptor Binding to Composite NF-AT/Activator Protein-1 Elements (2001)

Increased expression of a number of cytokines including GM-CSF is associated with chronic inflammatory conditions such as bronchial asthma. Glucocorticoid therapy results in suppression of cytokine levels by a mechanism(s) not yet fully understood. We have examined regulation of GM-CSF expression by the synthetic glucocorticoid dexamethasone in human T cells. Transient transfection assays with reporter constructs revealed that dexamethasone inhibited the function of the GM-CSF enhancer, but had no effect on regulation of GM-CSF expression occurring through the proximal promoter. Activation of the GM-CSF enhancer involves cooperative interaction between the transcription factors NF-AT and AP-1. We demonstrate here that glucocorticoid-mediated inhibition of enhancer function involves glucocorticoid receptor (GR) binding to the NF-AT/AP-1 sites. These elements, which do not constitute recognizable glucocorticoid response elements, support binding of the GR, primarily as a dimer. This binding correlates with the ability of dexamethasone to inhibit enhancer activity of the NF-AT/AP-1 elements, suggesting a competition between NF-AT/AP-1 proteins and GR.
The FrameNet tagset for frame-semantic and syntactic coding of predicate-argument structure (2000)

This paper presents the syntactic and semantic tags used to annotate predicate-argument structure in the Berkeley FrameNet Project. It briefly explains the theory of frame semantics on which semantic annotation is based, discusses possible applications of FrameNet annotation, and compares FrameNet to other prominent lexical resources.
Low-frequency Raman-active modes in .alpha.-methyl,.omega.-hydroxyoligo(oxyethylene)s (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLow-frequency Raman-active modes in .alpha.-methyl,.omega.-hydroxyoligo(oxyethylene)sCarl Campbell, Kyriakos Viras, Andrew J. Masters, John R. Craven, Zhang Hao, Stephen G. Yeates, and Colin BoothCite this: J. Phys. Chem. 1991, 95, 12, 4647–4651Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/j100165a012https://doi.org/10.1021/j100165a012research-articleACS PublicationsRequest reuse permissionsArticle Views55Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts