gebhart/patrepeval huggingface dataset:
Understanding and mitigating refresh overheads in high-density DDR4 DRAM systems (2013)

Recent DRAM specifications exhibit increasing refresh latencies. A refresh command blocks a full rank, decreasing available parallelism in the memory subsystem significantly, thus decreasing performance. Fine Granularity Refresh (FGR) is a feature recently announced as part of JEDEC's DDR4 DRAM specification that attempts to tackle this problem by creating a range of refresh options that provide a trade-off between refresh latency and frequency. In this paper, we first conduct an analysis of DDR4 DRAM's FGR feature, and show that there is no one-size-fits-all option across a variety of applications. We then present Adaptive Refresh (AR) , a simple yet effective mechanism that dynamically chooses the best FGR mode for each application and phase within the application. When looking at the refresh problem more closely, we identify in high-density DRAM systems a phenomenon that we call command queue seizure , whereby the memory controller's command queue seizes up temporarily because it is full with commands to a rank that is being refreshed. To attack this problem, we propose two complementary mechanisms called Delayed Command Expansion (DCE) and Preemptive Command Drain (PCD) . Our results show that AR does exploit DDR4's FGR effectively. However, once our proposed DCE and PCD mechanisms are added, DDR4's FGR becomes redundant in most cases, except in a few highly memory-sensitive applications, where the use of AR does provide some additional benefit. In all, our simulations show that the proposed mechanisms yield 8% (14%) mean speedup with respect to traditional refresh, at normal (extended) DRAM operating temperatures, for a set of diverse parallel applications.
Baculovirus recombinant expressing a secreted form of a transmembrane carcinoma-associated antigen. (1992)

GA733-2 is a monoclonal antibody-defined, 40-kDa glycoprotein antigen that is associated with carcinomas of various origins. Hydrophobicity analysis of the protein sequence predicted by complementary DNA (cDNA) has suggested that the GA733-2 antigen is a type I membrane protein. In this study, the polymerase chain reaction was used in a strategy to omit cDNA sequences for the transmembrane and cytoplasmic domains, thereby converting the extracellular domain into a secretory protein. Full-length and truncated cDNAs were cloned into the baculovirus transfer vector pVL1392 and introduced into Autographa californica nuclear polyhedrosis virus by homologous recombination. The full-length cDNA baculovirus recombinant directed the expression of a 40-kDa glycoprotein that was confined to infected Spodoptera frugiperda cells, whereas cells infected with the truncated cDNA baculovirus recombinant abundantly secreted a 31-kDa glycoprotein into the culture medium. Recombinant secretory antigen displayed an in vitro immunoreactivity to monoclonal antibody and an in vivo immunogenicity in mice that were similar to native antigen. The facile purification of mg quantities of carcinoma-associated antigen will enable an evaluation of its immunogenicity in cancer patients.
Chromatic-dispersion compensator using virtually imaged phased array (1997)

A new method for chromatic-dispersion compensation is proposed and demonstrated. This method can produce a chromatic dispersion practically in a wide range from -2000 to +2000 ps/nm and can compensate simultaneously for the dispersion of over 60 wavelength channels with 100-GHz spacing in a wavelength-division multiplexed (WDM) system that has a total bandwidth of over 50 nm. This method has further attractive features such as very small polarization-state dependence, mechanically variable chromatic dispersion, and potential for small packaging. It was experimentally confirmed that this method compensated for the chromatic dispersion accumulated through 110 km standard single-mode fiber (SMF) at 1.55-μm wavelength and that 10-Gb/s signal quality was clearly recovered after the 110-km transmission.
Comprehensive calibration for MIMO system (2003)

A comprehensive calibration procedure for MIMO system is proposed. This technique is able to eliminate effects of the following three unwanted components from MIMO measurement data, i.e. multiple transmitters characteristic, multiple receivers characteristic, and mutual coupling in array antenna elements. The numerical simulation proves that there is an improvement in the DOA estimator employing the proposed calibration technique compared with that employing conventional calibration or without any calibration.
The Prognostic Value of Serum Troponin T in Unstable Angina (1992)

Cardiac troponin T in serum appears to be a more sensitive indicator of myocardial-cell injury than serum creatine kinase MB activity, and its detection in the circulation may be a useful prognostic indicator in patients with unstable angina.
Cell Surface Antigen Expression in Human Erythroid Progenitors: Erythroid and Megakaryocytic Markers (1994)

This review summarizes the changes in cell surface antigen expression during proliferation and differentiation of human erythroid progenitors. The content is based on our experimental data obtained from complement-mediated cytotoxicity assays against hematopoietic progenitors and a combined technique of sequential micromanipulations of paired daughter cells derived from erythroid burst-forming units (BFU-E) and immunostaining with a panel of monoclonal antibodies, as well as from current information. BFU-E has CD34, CD41a (platelet glycoprotein[GP]IIb/IIIa) and CD41b(GPIIb) antigens. Paired daughter cells derived from BFU-E have CD41a, CD41b, CD71 (transferrin receptor) and HLA-DR antigens, but not CD34 or CD33 antigen. The CD36 antigen (thrombospondin receptor or GPIV) is first expressed on the cells after 5 days of culture, in agreement with the report that the anti-CD36 positive fraction contained a greater part of the erythroid colony-forming units (CFU-E). The blood group A antigen is first expressed on cells from aggregates derived from BFU-E after 5 days of culture. Glycophorin A is expressed on cell surface after 7 days of culture when proerythroblasts first appear. Hemoglobin alpha is expressed after 8 days of culture and coincides with the first appearance of basophilic erythroblasts. This review provides useful information on the identification of leukemic cells from poorly differentiated acute leukemias such as early erythroblastic leukemia and acute megakaryoblastic leukemia, and is useful in the understanding of the commitment and differentiation of erythroid and megakaryocytic progenitors in normal hematopoiesis.
The phase-shaped binary transmission (PSBT): a new technique to transmit for beyond the chromatic dispersion limit (1996)

This paper is an introduction to phase-shaped binary transmissions (PSBT), which allow to bridge more than 200 km in the linear regime over standard dispersive fibres. It also explains why duobinary transmissions did bridge up to 243 km. The spectral compression induced by the duobinary coding is not able to explain the impressive results obtained during recent experiments of optical phase-coded duobinary transmissions. We showed that the /spl Pi/ phase shift occurring in each O neighbouring a 1 allows the energy of the pulse over a longer distance in the 1 bit-time to be kept. This result has been confirmed analytically and numerically. The value of the optimal phase shift may vary depending on the rise- and fall-times of the phase modulation. We have named phase-shaped binary transmission (PSBT) on this principle.
Synthesis of 4,6-dinitrobenzo[b]furans from 1,3,5-trinitrobenzene (2005)

O-3,5-Dinitrophenylketoximes obtained by treatment of ketoximes with 1,3,5-trinitrobenzene undergo acid-catalysed cyclization to give 4,6-dinitrobenzo[b]furans substituted at the 2- or 2- and 3-positions.
Acetylation of PAMAM dendrimers for cellular delivery of siRNA (2009)

Primary amine acetylation of PAMAM dendrimers reduced their cytotoxicity to U87 cells, and promoted the release of siRNA from dendrimer/siRNA complexes. A modest fraction (approximately 20%) of primary amines of PAMAM can be modified while maintaining the siRNA delivery efficiency of unmodified PAMAM, but higher degrees of amine neutralization reduced the gene silencing efficiency of PAMAM/siRNA delivery vectors.
A Novel Group of Transcriptional Repressors in Arabidopsis (2009)

We showed previously that the ERF-associated amphiphilic repression (EAR) motif is a plant-specific repression domain that contains the conserved amino acid sequence LXLXL. In this report, we describe the identification of a novel repression domain, L/VR/KLFGVXM/V/L, which is different from known EAR motifs, in B3 DNA-binding domain transcription factors in Arabidopsis. Database analysis revealed that 29 Arabidopsis transcription factors, which included members of the RAV, ARF, Hsf and MYB families, contain the R/KLFGV conserved motif found in the novel repression domain. We demonstrated that factors that contain the R/KLFGV motif, namely, RAV1, RAV2, HsfB1 and HsfB2b, exhibited the repressive activity.
Developmental and age-related processes that influence the longevity and senescence of photosynthetic tissues in arabidopsis. (1993)

Factors that influence the longevity and senescence of photosynthetic tissues of Arabidopsis were investigated. To determine the influence of reproductive development on the timing of somatic tissue senescence, the longevity of rosette leaves of the Landsberg erecta strain and of isogenic mutant lines in which flowering is delayed (co-2) or sterile flowers are produced (ms1-1) were compared. No difference in the timing of senescence of individual leaves was observed between these lines, indicating that somatic tissue longevity is not governed by reproductive development in this species. To examine the role of differential gene expression in the process of leaf senescence, cDNA clones representing genes that are differentially expressed in senescing tissues were isolated. Sequence analysis of one such clone indicated homology to previously cloned cysteine proteinases, which is consistent with a role for the product of this gene in nitrogen salvage. RNA gel blot analysis revealed that increased expression of senescence-associated genes is preceded by declines in photosynthesis and in the expression of photosynthesis-associated genes. A model is presented in which it is postulated that leaf senescence is triggered by age-related declines in photosynthetic processes.
Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines (2013)

Although both erlotinib and gefitinib target the EGF receptor (EGFR), erlotinib is effective in patients with EGFR wild-type or mutated tumors, whereas gefitinib is only beneficial for patients with activating mutations. To determine whether these differences in clinical outcomes can be attributed to their respective protein interaction profiles, a label-free, quantitative chemical proteomics study was conducted. Using this method, 24 proteins were highlighted in the binding profiles of erlotinib and gefitinib. Unlike gefinitib, erlotinib displaced the ternary complex formed by integrin-linked kinase (ILK), α-parvin, and PINCH (IPP). The docking of erlotinib in the three-dimensional structure of ILK showed that erlotinib has the ability to bind to the ATP-binding site, whereas gefitinib is unlikely to bind with high affinity. As the IPP complex has been shown to be involved in epithelial-to-mesenchymal transition (EMT) and erlotinib sensitivity has been correlated with EMT status, we used a cellular model of inducible transition and observed that erlotinib prevented EMT in a more efficient way than gefitinib by acting on E-cadherin expression as well as on IPP levels. A retrospective analysis of the MERIT trial indicated that, besides a high level of E-cadherin, a low level of ILK could be linked to clinical benefit with erlotinib. In conclusion, we propose that, in an EGFR wild-type context, erlotinib may have a complementary mode of action by inhibiting IPP complex activities, resulting in the slowing down of the metastatic process of epithelial tumors.
Deinterlacing based on modularization by local frequency characteristics (2006)

We present a new deinterlacing algorithm based on modularization by the local frequency characteristics of images. The input patterns of an image are divided into two regions—the edge region and the smooth region. Each region is assigned to one neural network. The local frequency characteristics of patterns are similar within each region, resulting in more accurate training for each network. The regional neural networks are composed of two modules. One is for the low-frequency components of the input pattern, and the other is for the high-frequency components. Both modules are combined in the output. Therefore, each module compensates for the drawbacks of the other. In simulation, the proposed algorithm showed better performances in both still images and video sequences than other algorithms.
MECHANISMS OF ZYMOGEN ACTIVATION (1977)

Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific ...Read More
The study of kinematic transients in locomotion using the integrated kinematic sensor (1996)

A system based on the integrated kinematic sensor (IKS) was used to study the three-dimensional (3-D) kinematics of human lower limb during walking and running. The linear displacement, angular velocity, and linear acceleration of the foot, shank, and thigh segments were directly measured using three IKS's. The results clearly showed the heel strike impact in both walking and running, illustrating the high frequency components that exist in those activities. This paper illustrates the limitations of standard position measurements to capture transients associated with phase transitions, not only in acceleration estimates, but also in the determination of segmental angular velocities. An error analysis was conducted to determine the relative contribution of the accelerometer and the angular rate sensor to the determination of the segmental center of mass (COM) acceleration. The results suggest that in practical kinesiological applications, adding either an accelerometer or an angular rate sensor can remarkably increase the accuracy of segmental COM acceleration estimates.
Thalidomide in the treatment of patients with hepatocellular carcinoma (2005)

With a 5% PR rate, a 5% MR rate, and a 31% SD rate, the results indicate that thalidomide mostly may offer HCC patients disease stabilization. It is possible that, at a different dosage, or combined with other chemotherapy agents, or with the use of a different thalidomide analogue, longer patient survival may be achieved. However, in view of the significant neurologic toxicity encountered among these commonly cirrhotic HCC patients, thalidomide monotherapy at the high doses studied cannot be recommended for the treatment of HCC.
Combined Web/mobile authentication for secure Web access control (2004)

Previous Web access authentication systems have used either the Web or the mobile channel individually to confirm the claimed identity of the remote user. Both approaches proved to be insecure when used in isolation. An investigation is presented into the enhanced security of a new combined Web/mobile authentication system. The hybrid system enables a strong authentication by augmenting the traditional Web-based username/password approach with a mobile-based challenge/response authentication. Experiments show that the combined system is relatively immune to eavesdropping attacks and provides a trade-off between security and usability of the remote authentication system. The system is promising for current as well as for future 3G mobile and pervasive computing environments [A. Al-Qayedi et al., 2003].
Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit. (1983)

Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3.1.26) and mucosal cytosol by cholesterol esterase (EC 3.1.1.13) was studied. Compound 57-118. N-(1-oxo-9-octadecenyl)-DL-tryptophan(Z)ethyl ester, an inhibitor of cholesterol absorption, was found to inhibit in vitro ACAT in mucosal microsomes at concentrations of 2-20 nmol/0.5 ml incubation mixture, but had no effect on cholesterol esterase in the cytosol at similar concentrations. A kinetic analysis using a Lineweaver-Burk plot indicates that 57-118 acts as a competitive inhibitor of ACAT. An ex vivo study in the rabbit where 57-118 was given by gavage at a dose of 200 mg/kg also showed inhibition of ACAT but not of cholesterol esterase. High performance liquid chromatography determination of 57-118 in various subcellular fractions demonstrated the presence of this substance after oral administration in concentrations in mucosal microsomes equivalent to those required to show inhibition of ACAT in vitro. These data support the work of Norum et al. (1979, Eur. J. Clin. Invest. 9: 55-62) indicating mucosal ACAT plays a significant role in cholesterol absorption.
Demonstration of the XWand Interface for Intelligent Spaces (2002)

The XWand is a novel wireless sensor package that enables styles of natural interaction with intelligent environments. For example, a user may point the wand at a device and control it using simple gestures. The XWand system leverages the intelligence of the environment to best determine the user’s intention. We demonstrate the wand hardware device and multimodal (wand and speech) interpretation process in variety of device control scenarios, including lighting, media player, and cursor control.
Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (2002)

Prednisone, 10 mg/d, provides clinical benefit, particularly in the first 6 months, and substantially inhibits progression of radiologic joint damage in patients with early active rheumatoid arthritis and no previous treatment with disease-modifying antirheumatic drugs. Because of their limited disease-modifying effects, glucocorticoids should be combined with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.
Structure of thrombospondin. (1984)

The NH2-terminal amino acid sequences of thrombospondin and of a 30,000-Da heparin-binding peptide derived from thrombospondin by treatment with plasmin are identical. The heparin-binding peptide is homogeneous in size but slightly heterogeneous in charge with the predominant isoelectric points being 6.1 and 5.7. Electron microscopy of tungsten replicas of thrombospondin reveals a tripartite structure resembling a "bola" which is about 60 nm across when fully extended. Each part of the molecule terminates in a globular node or head which disappears upon limited plasmin digestion, suggesting that the heparin-binding peptide is located in the head region. In addition to the heparin-binding peptide, a 20,000-Da peptide also apparently associated with the head region is liberated during proteolysis. The electron micrographs indicate that the legs of the bola-like structure must be folded into an extended, flexible, tertiary structure. These legs, each of about 65,000 Da, appear to be attached near the ends opposite the heads, probably by disulfide bonds. Each leg possesses a tab or protein (approximately 20,000 Da) which juts out from this attachment point.
A Novel Transcriptional Inhibitor Induces Apoptosis in Tumor Cells and Exhibits Antiangiogenic Activity (2006)

Using a high-throughput cell-based assay, we identified a nucleoside analogue 4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide (ARC), which has the properties of a general transcriptional inhibitor. Specifically, ARC inhibits the phosphorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in transcriptional elongation. ARC was able to potently repress p53 targets p21 and hdm2 (human homologue of mdm2) protein levels, but dramatically increased p53 levels similar to other transcriptional inhibitors, including flavopiridol. This increase in p53 corresponded to the down-regulation of short-lived protein hdm2, which is a well-established negative regulator of p53. Remarkably, ARC induced potent apoptosis in human tumor and transformed, but not in normal cells, and possessed strong antiangiogenic activity in vitro. Although ARC promoted the accumulation of p53, ARC-induced apoptosis in tumor cells was p53-independent, suggesting that it may be useful for the treatment of tumors with functionally inactive p53. Furthermore, cell death induced by ARC had a strong correlation with down-regulation of the antiapoptotic gene survivin, which is often overexpressed in human tumors. Taken together, our data suggests that ARC may be an attractive candidate for anticancer drug development.
Mouse macrophage elastase. Purification and characterization as a metalloproteinase (1981)

Macrophage elastase was purified from tissue-culture medium conditioned by inflammatory mouse peritoneal macrophages. Characterized as a secreted neutral metalloproteinase, this enzyme was shown to be catalytically and immunochemically distinct from the mouse pancreatic and mouse granulocyte elastases, both of which are serine proteinases. Inhibition profiles, production of nascent N-terminal leucine residues and sodium dodecyl sulphate/polyacrylamide-gel electrophoresis of degraded elastin indicated that macrophage elastase is an endopeptidase, with properties of a metalloproteinase, rather than a serine proteinase. Macrophage elastase was inhibited by alpha 2-macroglobulin, but not by alpha 1-proteinase inhibitor. Macrophage elastase was resolved into three chromatographically distinct forms. The predominant form had mol.wt. 22 000 and was purified 4100-fold. Purification of biosynthetically radiolabelled elastase indicated that this form represented less than 0.5% of the secreted protein of macrophages. Approx. 800% of the starting activity was recovered after purification. Evidence was obtained for an excess of an endogenous inhibitor masking more than 80% of the secreted activity.
Surface Acetylation of Polyamidoamine (PAMAM) Dendrimers Decreases Cytotoxicity while Maintaining Membrane Permeability (2007)

Improving the oral bioavailability of therapeutic compounds remains a challenging area of research. Polyamidoamine (PAMAM) dendrimers are promising candidates for oral drug delivery due to their well-defined compact structure, versatility of surface functionalities, low polydispersity, and ability to enhance transepithelial transport. However, potential cytotoxicity has hampered the development of PAMAM dendrimers for in vivo applications. In this article, we have systematically modified the surface groups of amine-terminated PAMAM dendrimers with acetyl groups. The effect of this modification on cytotoxicity, permeability, and cellular uptake was investigated on Caco-2 cell monolayers. Cytotoxicity was reduced by more than 10-fold as the number of surface acetyl groups increased while maintaining permeability across the cell monolayers. Furthermore, a decrease in nonspecific binding was evident for surface-modified dendrimers compared to their unmodified counterparts. These studies point to novel strategies for minimizing PAMAM dendrimer toxicity while maximizing their transepithelial permeability.
Zola e Gonzaga Duque: o artista e a cidade na virada do século (2011)

O objetivo desse ensaio é ler comparativamente o mundo das artes e a cidade no final século XIX e início do XX em dois romances, L’Oeuvre, de Émile Zola, e Mocidade Morta, de Gonzaga Duque, mostrando seus pontos de contato e suas especificidades.