gebhart/patrepeval huggingface dataset:
Venous and arterial thrombosis following administration of intravenous immunoglobulins (2005)

Thrombotic events are an increasingly recognized complication of treatment with intravenous immunoglobulins (IVIg). We aimed to define clinical characteristics, risk factors and outcome for venous thrombosis as opposed to arterial thrombosis following administration of IVIg. Six patients with post-IVIg venous thrombosis were identified at our institution. In addition, a review of the literature revealed 65 reported cases. Arterial thrombosis (stroke and myocardial infarction) was four times more common than venous thrombosis (deep vein thrombosis and pulmonary embolism). The incidence rate was estimated at 0.15-1.2% per treatment course, but the large increase in reported cases in 2003 suggests that the true incidence may be significantly greater. The following differences were found between arterial and venous events: arterial thrombosis occurred early after IVIg administration (49% within 4 h, 77% within 24 h) and was associated with advanced age and atherosclerotic vascular disease; venous thrombosis occurred later (54% more than 24 h after IVIg administration) and was associated with factors contributing to venous stasis (obesity and immobility). Thirteen patients died (mortality 20%), 11 of whom had arterial thrombosis. In conclusion, IVIg-associated thrombosis is more common than previously recognized, and is associated with significant mortality. The different characteristics of arterial and venous events may reflect different pathophysiological mechanisms. A better understanding of these mechanisms should aid in defining a risk-benefit ratio for the individual patient.
The effects of telomerase inhibitors on lymphocyte function. (2000)

Immunosuppression may result from the use of telomerase inhibitors during chemotherapy but should only be temporary.
Kepuasan Kerja dan Komitmen Organisasional: Pengaruhnya Terhadap Intensi Keluar (2013)

Job satisfaction is a major determinant of organizational commitment and intention turnover . This study aimed to determine the effect of job satisfaction and organizational commitment to intention turnover . Using a 105 sample from a 412 population , with a response rate of 97.14 % obtained the data as much as 102 questionnaires that had been completed . Collected data were analyzed by Structural Equation Modelling ( SEM) using smart PLS sofware. The results showed that a significant positive effect of job satisfaction on organizational commitment and negarif significant effect on the intention turnover . Similarly, commitment organisional is significant negative effect on intention turnover . The implications of this study is must be maintain the level of intention turnover by increasing job satisfaction to be increased organizational commitment . Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */
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Leukopheresis therapy of leukemic reticuloendotheliosis (hairy cell leukemia) (1979)

Intensive leukopheresis has been valuable in the short-term palliation of chronic lymphocytic and granulocytic leukemias. A 47-yr-old man with refractory leukemic reticuloendotheliosis (hairy cell leukemia) manifested by anemia, thrombocytopenia, elevated peripheral leukemia cell counts, generalized lymph node enlargement, and leukemic infiltrative skin disease was treated with serial leukopheresis. Removal of approximately 7 X 10(11) peripheral leukemia cells resulted in marked clinical and hematologic improvement with resolution of enlarged lymph nodes and clearing of skin infiltrates. At the time of this reporting, more than 400 wk since the last leukopheresis, the patient continues to do well. The improvement in all blood counts, reduction in lymph node size, and clearing of skin lesions paralleled the reduction of peripheral leukemia cell load by leukopheresis, suggesting mobilization of leukemia cells from marrow, lymph nodes, and skin. Removal of large numbers of leukemia cells in hairy cell leukemia has the potential of achieving sustained clinical improvement and may be a useful alternative therapy for these patients.
Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism (2011)

The identity of the cell type responsive to sclerostin, a negative regulator of bone mass, is unknown. Since sclerostin is expressed in vivo by mineral-embedded osteocytes, we tested the hypothesis that sclerostin would regulate the behavior of cells actively involved in mineralization in adult bone, the preosteocyte. Differentiating cultures of human primary osteoblasts exposed to recombinant human sclerostin (rhSCL) for 35 days displayed dose- and time-dependent inhibition of in vitro mineralization, with late cultures being most responsive in terms of mineralization and gene expression. Treatment of advanced (day 35) cultures with rhSCL markedly increased the expression of the preosteocyte marker E11 and decreased the expression of mature markers DMP1 and SOST. Concomitantly, matrix extracellular phosphoglycoprotein (MEPE) expression was increased by rhSCL at both the mRNA and protein levels, whereas PHEX was decreased, implying regulation through the MEPE-ASARM axis. We confirmed that mineralization by human osteoblasts is exquisitely sensitive to the triphosphorylated ASARM-PO4 peptide. Immunostaining revealed that rhSCL increased the endogenous levels of MEPE-ASARM. Importantly, antibody-mediated neutralization of endogenous MEPE-ASARM antagonized the effect of rhSCL on mineralization, as did the PHEX synthetic peptide SPR4. Finally, we found elevated Sost mRNA expression in the long bones of HYP mice, suggesting that sclerostin may drive the increased MEPE-ASARM levels and mineralization defect in this genotype. Our results suggest that sclerostin acts through regulation of the PHEX/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization, consistent with its localization in vivo and its established role in the inhibition of bone formation.
Liver Tumors: Utility of Characterization at Dual-Frequency US (1999)

Changes in CNRs of relatively high- and low-frequency US images may give useful information on the frequency dependence of backscattering, which is descriptive of the histologic findings in lesions and which is not evident with conventional US images.
Adult stem cells (2003)

Development of a multicellular organism is accomplished through a series of events that are preprogrammed in the genome. These events encompass cellular proliferation, lineage commitment, lineage progression, lineage expression, cellular inhibition, and regulated apoptosis. The sequential progression of cells through these events results in the formation of the differentiated cells, tissues, and organs that constitute an individual. Although most cells progress through this sequence during development, a few cells leave the developmental continuum to become reserve precursor cells. The reserve precursor cells are involved in the continual maintenance and repair of the tissues and organs throughout the life span of the individual. Until recently it was generally assumed that the precursor cells in postnatal individuals were limited to lineage-committed progenitor cells specific for various tissues. However, studies by Young, his colleagues, and others have demonstrated the presence of two categories of precursor cells that reside within the organs and tissues of postnatal animals. These two categories of precursor cells are lineage-committed (multipotent, tripotent, bipotent, and unipotent) progenitor cells and lineage-uncommitted pluripotent (epiblastic-like, ectodermal, mesodermal, and endodermal) stem cells. These reserve precursor cells provide for the continual maintenance and repair of the organism after birth.
Atomic Mapping of the Interactions between the Antiviral Agent Cyanovirin-N and Oligomannosides by Saturation-Transfer Difference NMR (2004)

The minimum oligosaccharide structure required for binding to the potent HIV-inactivating protein cyanovirin-N (CV-N) was determined by saturation-transfer difference (STD) NMR spectroscopy. Despite the low molecular mass of the protein (11 kDa), STD-NMR spectroscopy allowed the precise atomic mapping of the interactions between CV-N and various di- and trimannosides, substructures of Man-9, the predominant oligosaccharide on the HIV viral surface glycoprotein gp120. Contacts with mannosides containing the terminal Manalpha(1-->2)Manalpha unit of Man-9 were observed, while (1-->3)- and (1-6)-linked di- and trimannosides showed no interactions, demonstrating that the terminal Manalpha(1-->2)Manalpha structure plays a key role in the interaction. Precise epitope mapping revealed that, for Manalpha(1-->2)ManalphaOMe, Manalpha(1-->2)Manalpha(1-->3)ManalphaOMe, and Manalpha(1-->2)Manalpha(1-->6)ManalphaOMe, the protein is in close contact with H2, H3, and H4 of the nonreducing terminal mannose unit. In contrast, the STD-NMR spectrum of the CV-N/trisaccharide Manalpha(1-->2)Manalpha(1-->2)ManalphaOMe complex was markedly different, with resonances on all sugar units displaying equal enhancements, suggesting that CV-N is able to discriminate between the three structurally related trisaccharides.
Appearance of specific antibody-bearing cells in human bronchial mucosa after local immunization with bacterial vaccine (1986)

The immune response to local in vivo inhalation of a lysed bacteria vaccine was assessed in surgical specimens of main-stem bronchi from patients who had undergone pneumectomy for cancer. The patient population included 22 subjects; 11 of these received the aerosol vaccine twice a day for 10 days prior to surgery, while the remaining 11 patients were used as controls and were not immunized. The submucous glands of immunized subjects showed significantly more cells than did those of the controls, i.e., 62 +/- 8 versus 37 +/- 7, respectively (P less than 0.05). The following five antigens were chosen for study by fluorescence assay: Streptococcus pneumoniae types II and III, Haemophilus influenzae, Streptococcus sp. strain D19, and Klebsiella pneumoniae. An immunization-dependent correlation was found between immunoglobulin A, immunoglobulin A-bearing cells, and specific antibody-bearing cells on the one hand and three of the five antigens (S. pneumoniae types II and III and Streptococcus sp. strain D19) on the other hand. This is the first time that a relationship has been established between bacterial immunization of the lower respiratory tract and local immunoglobulin production in humans.
Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity (2005)

The establishment and stability of cell fates during development depend on the integration of multiple signals, which ultimately modulate specific patterns of gene expression. While there is ample evidence for this integration at the level of gene regulatory sequences, little is known about its operation at other levels of cellular activity. Wnt and Notch signalling are important elements of the circuitry that regulates gene expression in development and disease. Genetic analysis has suggested that in addition to convergence on the transcription of specific genes, there are modulatory cross-regulatory interactions between these signalling pathways. We report that the nodal point of these interactions is an activity of Notch that regulates the activity and the amount of the active/oncogenic form of Armadillo/beta-catenin. This activity of Notch is independent of that induced upon cleavage of its intracellular domain and which mediates transcription through Su(H)/CBF1. The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt signalling which is likely to play important roles in both normal and pathological situations.
A study of the photochemical response of o‐nitrobenzyl cholate derivatives in P(MMA‐MAA) matrices (1983)

Abstract Ortho ‐nitrobenzyl cholate esters have been successfully used as photosensitive components in solution inhibition deep UV photoresists. The photochemical behavior of a variety of substituted o ‐nitrobenzyl cholate derivaties has been examined and resist sensitivity is related to the quantum yield of the reaction. The most efficient system examined is o , o ′‐dinitrobenzyl cholate/P(MMA‐MMA), where the quantum yield of photoreaction is 0.2 and resist sensitivity is ca. 150 mJ/cm 2 for a 1.5 μm film. The mode of resist behaviour on irradiation and development is also reported.
Transferring color to greyscale images (2002)

We introduce a general technique for "colorizing" greyscale images by transferring color between a source, color image and a destination, greyscale image. Although the general problem of adding chromatic values to a greyscale image has no exact, objective solution, the current approach attempts to provide a method to help minimize the amount of human labor required for this task. Rather than choosing RGB colors from a palette to color individual components, we transfer the entire color "mood" of the source to the target image by matching luminance and texture information between the images. We choose to transfer only chromatic information and retain the original luminance values of the target image. Further, the procedure is enhanced by allowing the user to match areas of the two images with rectangular swatches. We show that this simple technique can be successfully applied to a variety of images and video, provided that texture and luminance are sufficiently distinct. The images generated demonstrate the potential and utility of our technique in a diverse set of application domains.
Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment (2002)

Type I allergy is an immunoglobulin E (IgE)-mediated hypersensitivity disease affecting more than 25% of the population. Currently, diagnosis of allergy is performed by provocation testing and IgE serology using allergen extracts. This process defines allergen-containing sources but cannot identify the disease-eliciting allergenic molecules. We have applied microarray technology to develop a miniaturized allergy test containing 94 purified allergen molecules that represent the most common allergen sources. The allergen microarray allows the determination and monitoring of allergic patients' IgE reactivity profiles to large numbers of disease-causing allergens by using single measurements and minute amounts of serum. This method may change established practice in allergy diagnosis, prevention, and therapy. In addition, microarrayed antigens may be applied to the diagnosis of autoimmune and infectious diseases.
ORGANIZATION OF HAEMOPOIETIC STEM CELLS: THE GENERATION‐AGE HYPOTHESIS (1979)

ABSTRACT This paper proposes that the previous division history of each stem cell is one determinant of the functional organization of the haemopoietic stem cell population. Stem cells from a lineage of stem cells which have generated many stem cells (older stem cells) are used in the animal to form blood before stem cells which have generated few stem cells (younger stem cells). The stem cell generating capacity of a lineage of stem cells is finite. After a given number of generations a stem cell is lost to the stem cell compartment by forming two committed precursors of the cell lines. Its part in blood formation is taken by the next oldest stem cell. We have called this proposal the generation‐age hypothesis. Experimental evidence in support of the proposal is presented. We stripped away older stem cells from normal bone marrow and 12 day foetal liver with phase‐specific drugs and revealed a younger population of stem cells whose capacity for stem cell generation was three‐ to four‐fold greater than that of the average normal, untreated population. We aged normal stem cells by continuous irradiation and serial retransplantation and found that their stem cell generative capacity had declined eight‐fold. We measured the stem cell generative capacity of stem cells in the bloodstream. It was a half, to a quarter that of normal bone marrow stem cells and we found a subpopulation of circulating stem cells whose capacity for stem cell generation was an eighth to a fortieth that of normal femoral stem cells. This subpopulation was identified by its failure to express the brain‐associated antigen which was present on 75% of normal femoral stem cells but was not found on their progeny, the committed precursors of granulocytes.
Mid-infrared properties of aVO2film near the metal-insulator transition (1996)

A ${\mathrm{VO}}_{2}$ film was grown on a sapphire(0001) substrate using pulsed laser deposition. The film showed a first-order metal-insulator (MI) transition and its dc conductivity started to increase drastically near 68 \ifmmode^\circ\else\textdegree\fi{}C and changed by three orders of magnitude. Mid-infrared transmittance and reflectance spectra of the ${\mathrm{VO}}_{2}$ film were measured between 20 \ifmmode^\circ\else\textdegree\fi{}C and 90 \ifmmode^\circ\else\textdegree\fi{}C. Using the intensity transfer-matrix method, the frequency-dependent dielectric constant ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega}) and the conductivity ${\mathrm{\ensuremath{\sigma}}}_{\mathit{f}}$(\ensuremath{\omega}) of the film were obtained between 1600 and 4000 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ from the measured transmittance and reflectance spectra. With the ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega}) and ${\mathrm{\ensuremath{\sigma}}}_{\mathit{f}}$(\ensuremath{\omega}) spectra, mid-infrared properties of the ${\mathrm{VO}}_{2}$ film near the MI transition region were investigated in detail. Above 78 \ifmmode^\circ\else\textdegree\fi{}C, ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega})0 and d${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$/d\ensuremath{\omega}&gt;0, which is a typical metallic behavior. In particular, ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega}) and ${\mathrm{\ensuremath{\sigma}}}_{\mathit{f}}$(\ensuremath{\omega}) at 88 \ifmmode^\circ\else\textdegree\fi{}C were analyzed in terms of extended Drude model in which the frequency-dependent scattering rate and the effective mass could be obtained. The mean free path of charge carriers in the dc limit was estimated to be larger by an order of magnitude than the previously reported value, i.e., 4 \AA{}. Below 74 \ifmmode^\circ\else\textdegree\fi{}C, ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega})&gt;0 and d${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$/d\ensuremath{\omega}\ensuremath{\approxeq}0, which is characteristic of an insulator. Interestingly, ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$ in the insulating region increased as the temperature approached the MI transition temperature. To explain this anomalous behavior, the MI transition of the ${\mathrm{VO}}_{2}$ film was modeled with coexistence of metallic and insulating domains and their dynamic evolution. Then the behaviors of ${\mathrm{\ensuremath{\epsilon}}}_{\mathit{f}}$(\ensuremath{\omega}) and ${\mathrm{\ensuremath{\sigma}}}_{\mathit{f}}$(\ensuremath{\omega}) were explained using the effective medium approximation, which is a mean-field theory predicting a percolation transition. This work clearly demonstrates that the transport and optical properties near the MI transition region are strongly influenced by the connectivity of the metallic domains. \textcopyright{} 1996 The American Physical Society.
Prospective Controlled Trial of STAR Total Ankle Replacement versus Ankle Fusion: Initial Results (2009)

By 24 months, ankles treated with STAR ankle replacement (in both the Pivotal and Continued Access Groups) had better function and equivalent pain relief as ankles treated with fusion.
Optimally shaped terahertz pulses for phase retrieval in a Rydberg-atom data register (2001)

We employ optimal control theory to discover an efficient information-retrieval algorithm that can be performed on a Rydberg-atom data register using a shaped terahertz pulse. The register is a Rydberg wave packet with one consituent orbital phase reversed from the others (the ``marked bit''). The terahertz pulse that performs the decoding algorithm does so by driving electron probability density into the marked orbital. Its shape is calculated by modifying the target of an optimal-control problem so that it represents the direct product of all correct solutions to the algorithm.
Gastric (Reservoir) Reduction for Morbid Obesity (1981)

Since 1976, in 100 morbidly obese patients, the lesser curvature of the stomach has been inverted by performing a Nissen's fundoplication followed by gastric wrapping. All but one are losing weight satisfactorily and have early satiety. There was one postoperative death from pulmonary embolus. No harmful metabolic or physiologic changes have been detected. This procedure corrects or prevents esophageal reflux and enables the patient to control morbid obesity.
Photovoltaic Properties of Two-Dimensional (CH3NH3)2Pb(SCN)2I2 Perovskite: A Combined Experimental and Density Functional Theory Study (2016)

We explore the photovoltaic-relevant properties of the 2D MA2Pb(SCN)2I2 (where MA = CH3NH3(+)) perovskite using a combination of materials synthesis, characterization and density functional theory calculation, and determine electronic properties of MA2Pb(SCN)2I2 that are significantly different from those previously reported in literature. The layered perovskite with mixed-anions exhibits an indirect bandgap of ∼2.04 eV, with a slightly larger direct bandgap of ∼2.11 eV. The carriers (both electrons and holes) are also found to be confined within the 2D layers. Our results suggest that the 2D MA2Pb(SCN)2I2 perovskite may not be among the most promising absorbers for efficient single-junction solar cell applications; however, use as an absorber for the top cell of a tandem solar cell may still be a possibility if films are grown with the 2D layers aligned perpendicular to the substrates.