gebhart/patrepeval huggingface dataset:
A Multivariate Heuristic Model for Fuzzy Time-Series Forecasting (2007)

Fuzzy time-series models have been widely applied due to their ability to handle nonlinear data directly and because no rigid assumptions for the data are needed. In addition, many such models have been shown to provide better forecasting results than their conventional counterparts. However, since most of these models require complicated matrix computations, this paper proposes the adoption of a multivariate heuristic function that can be integrated with univariate fuzzy time-series models into multivariate models. Such a multivariate heuristic function can easily be extended and integrated with various univariate models. Furthermore, the integrated model can handle multiple variables to improve forecasting results and, at the same time, avoid complicated computations due to the inclusion of multiple variables.
Analysis and Design of Bulk Acoustic Wave Filters Based on Acoustically Coupled Resonators (2011)

El rapid creixement dels sistemes de telecomunicacions sense fils ha portat a una creixent demanda de dispositius mobils amb requisits cada vegada mes estrictes per als filtres de microones incloent un millor rendiment, miniaturitzacio i la reduccio de costos. Una nova tecnologia de filtres de RF s’ha consolidat en l'ultima decada: la tecnologia BAW. Els filtres BAW son perfectament adequats com a filtres miniaturitzats i d'alt rendiment per a aplicacions d'alta frequencia. En comparacio amb la tecnologia SAW, els filtres BAW proporcionen menors perdues d'insercio, una millor selectivitat, compatibilitat CMOS, millor maneig de potencia i una major frequencia de treball. Un CRF BAW es un dels mes recents filtres BAW que permet oferir una amplia gamma de noves i interessants propietats en comparacio dels seus predecessors. Basat en el concepte de ressonadors acoblats acusticament, es poden oferir respostes Chebyshev classiques i avancades, millor ample de banda, mes miniaturitzacio i conversio de mode. La complexitat d'un CRF es considerable en termes de disseny i fabricacio, a causa de la quantitat de lamines que el conformen. El disseny de filtres BAW es basa en dimensionar les capes del dispositiu. El disseny es complex i els procediments d'optimitzacio poden no ser eficients a causa de la quantitat de variables que intervenen en el proces. En aquest treball es presenta una metodologia d'analisi i sintesi. Les tecniques poden fer front a les estructures de diverses capes d'una manera directa. Es presenta un conjunt de models circuitals completament electrics que simplifiquen i recullen el comportament dels CRF, dispositius que funcionen tant en els dominis electric i mecanic. S'han establert un conjunt d'eines per analitzar el ressonador per mitja de teoria de xarxes i es la base per a l'analisi d'estructures compostes de diversos ressonadors i multiples capes de lamines primes. Es desenvolupa un model per al CRF utilitzant transformacions de xarxa i aproximacions respecte a les frequencies de funcionament dels dispositius BAW. Es presenta un analisi profund del BAW CRF amb els models proposats com una eina que permet guiar el procediment analitic. L'analisi dels filtres facilita una millor comprensio del seu funcionament i una manera d'establir els limits de les respostes que poden oferir. Es presenten metodologies de disseny de filtres amb la finalitat d'obtenir les geometries de l'estructura i la topologia dels filtres BAW per complir amb les respostes prescrites. El disseny del filtre es dona a partir d'una comprensio clara dels seus mecanismes de filtratge de manera que facilita l'explotacio de les seves caracteristiques inherents. Les respostes avancades amb zeros de transmissio o els filtres de banda de rebuig procedents dels nous dispositius presentats es sintetitzen per mitja de les metodologies proposades.
Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease (1996)

Studies suggest that thrombosis is important in the progression of atherosclerotic lesions. The biochemical markers prothrombin fragment 1-2 and fibrinopeptide A reflect in vivo thrombin generation and activity, respectively. As such, they are markers that might be associated with cardiovascular risk. From the Cardiovascular Health Study, a cohort study of 5201 persons over 65 years of age, 399 persons free of clinical cardiovascular disease (CVD) at the baseline examination were selected for study of specialized markers of hemostasis. We report the cross-sectional relationships of the thrombin markers to CVD risk factors and measures of subclinical CVD. The range of fragment 1-2 2 was 0.12 to 0.85 nmol/L. The range of fibrinopeptide A was 0.9 to 44.1 micrograms/L. High levels of fragment 1-2 and fibrinopeptide A were associated with age, with levels higher in women than men. Fragment 1-2 was associated with smoking; high levels of triglyceride, creatinine, and C-reactive protein; and low levels of glucose. Fibrinopeptide A was associated with high C-reactive protein and apolipoprotein(a) and lower ankle-brachial index. There were no significant associations of the thrombin markers with race, fibrinogen, alcohol consumption, diabetes, or most measures of subclinical CVD. Study findings support a hypothesis that there are physiological interrelationships between cardiac risk factors, hemostasis, inflammation, and progression of atherosclerosis.
EEG SOURCE LOCALIZATION: A COMPARATIVE STUDY OF CLASSICAL AND NEURAL NETWORK METHODS (2001)

We address the problem of estimating biopotential sources within the brain, based on EEG signals observed on the scalp. This problem, known as the inverse problem of electrophysiology, has no closed-form solution, and requires iterative techniques such as the Levenberg-Marquardt (LM) algorithm. Considering the nonlinear nature of the inverse problem, and the low signal to noise ratio inherent in EEG signals, a backpropagation neural network (BPN) has been recently proposed as a solution. The technique has not been properly compared with classical techniques such as the LM method, or with more recent neural network techniques such as the Radial Basis Function (RBF) network. In this paper, we provide improved strategies based on BPN and consider RBF networks in solving the inverse problem. We compare the performances of BPN, RBF and a hybrid technique with that of the classical LM method.
Vitamin K-dependent proteins in Ciona intestinalis , a basal chordate lacking a blood coagulation cascade (2006)

We have isolated and sequenced several cDNAs derived from the sea squirt Ciona intestinalis that encode vitamin K-dependent proteins. Four of these encode gamma-carboxyglutamic acid (Gla) domain-containing proteins, which we have named Ci-Gla1 through Ci-Gla4. Two additional cDNAs encode the apparent orthologs of gamma-glutamyl carboxylase and vitamin K epoxide reductase. Ci-Gla1 undergoes gamma-glutamyl carboxylation when expressed in CHO cells and is homologous to Gla-RTK, a putative receptor tyrosine kinase previously identified in a related ascidian. The remaining three Gla domain proteins are similar to proteins that participate in fundamental developmental processes, complement regulation, and blood coagulation. These proteins are generally expressed at low levels throughout development and exhibit either relatively constant expression (Ci-Gla1, gamma-glutamyl carboxylase, and vitamin K epoxide reductase) or spatiotemporal regulation (Ci-Gla2, -3, and -4). These results demonstrate the evolutionary emergence of the vitamin K-dependent Gla domain before the divergence of vertebrates and urochordates and suggest novel functions for Gla domain proteins distinct from their roles in vertebrate hemostasis. In addition, these findings highlight the usefulness of C. intestinalis as a model organism for investigating vitamin K-dependent physiological phenomena, which may be conserved among the chordate subphyla.
Structure elucidation of two triterpenoid tetrasaccharides from Androsace saxifragifolia (1986)

Saxifragifolins A and B, two new triterpenoid tetrasaccharides isolated from the aerial part of Androsace saxifragifolia, were respectively shown to be androsacenol-3-O-{β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranoside}(1) and cyclamiretin A 3-O-{β-D-xylopyranosyl-(1 → 2)-β-D-glucopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranoside}(2). The structural details were elucidated by a combination of fast-atom-bombardment mass spectrometry, chemical degradation, and one- and two-dimensional n.m.r. spectroscopy.
Accurate methods for the statistics of surprise and coincidence (1993)

Much work has been done on the statistical analysis of text. In some cases reported in the literature, inappropriate statistical methods have been used, and statistical significance of results have not been addressed. In particular, asymptotic normality assumptions have often been used unjustifiably, leading to flawed results.This assumption of normal distribution limits the ability to analyze rare events. Unfortunately rare events do make up a large fraction of real text.However, more applicable methods based on likelihood ratio tests are available that yield good results with relatively small samples. These tests can be implemented efficiently, and have been used for the detection of composite terms and for the determination of domain-specific terms. In some cases, these measures perform much better than the methods previously used. In cases where traditional contingency table methods work well, the likelihood ratio tests described here are nearly identical.This paper describes the basis of a measure based on likelihood ratios that can be applied to the analysis of text.
Immunohistochemical Analysis of Monocytic Leukemias (2011)

Detection of monocytic differentiation in myeloid neoplasms by immunohistochemical analysis is challenging owing to a lack of sensitive and/or specific antibodies. We tested the usefulness of immunohistochemical analysis for CD14, an antigen commonly detected by flow cytometry, and Krüppel-like factor 4 (KLF4), a potentially novel marker of monocytic differentiation, in a series of myeloid leukemias, including 53 acute myeloid leukemias with monocytic differentiation. These findings were compared with immunohistochemical findings for CD68 (KP-1), CD34, and CD163 and were also correlated with flow cytometric and enzyme cytochemical results. CD163 and CD14 are the most specific markers of monocytic differentiation, followed by KLF4. CD68, in contrast, is the most sensitive monocytic marker, and KLF4 is also significantly more sensitive than CD14 and CD163. These studies show that KLF4 is another marker of monocytic differentiation and that the combination of CD14 and CD163 can increase the diagnostic sensitivity for monocytic neoplasms.
Control-volume based Navier-Stokes equation solver valid at all flow velocities (1989)

A control-volume based finite difference method to solve the Reynolds averaged Navier-Stokes equations is presented. A pressure correction equation valid at all flow velocities and a pressure staggered grid layout are used in the method. Example problems presented herein include: a developing laminar channel flow, developing laminar pipe flow, a lid-driven square cavity flow, a laminar flow through a 90-degree bent channel, a laminar polar cavity flow, and a turbulent supersonic flow over a compression ramp. A k-epsilon turbulence model supplemented with a near-wall turbulence model was used to solve the turbulent flow. It is shown that the method yields accurate computational results even when highly skewed, unequally spaced, curved grids are used. It is also shown that the method is strongly convergent for high Reynolds number flows.
Soluble CD44 Is a Potential Marker for the Early Detection of Head and Neck Cancer (2007)

SolCD44 is elevated in the majority of HNSCC and distinguishes cancer from benign disease with high specificity. Whereas the solCD44 test lacks sensitivity by itself, methylation status of the CD44 gene seems to complement the solCD44 test. Our pilot data indicate that, together, these markers will detect HNSCC with very high sensitivity and specificity.
Exon skipping and Duchenne muscular dystrophy: Hope, hype and how feasible? (2008)

Duchenne muscular dystrophy (DMD), the most common and serious form of childhood muscle wasting is generally caused by protein-truncating mutations in the large DMD gene. Specific removal of an exon from a defective DMD gene transcript has the potential to allow synthesis of a semi-functional dystrophin, thereby reducing the severity and presumably progression of muscle wasting. The efficacy of this treatment will vary greatly between the different mutations that preclude the synthesis of a functional dystrophin. Restoration of the reading frame from a large multi-exon genomic deletion, typically greater than 36 exons, may lead to synthesis of a protein with only partial function and limited clinical benefit, whereas excising a nonsense mutation in a redundant exon should generate a near normal dystrophin. A clinical trial has recently confirmed proof-of-principle that exclusion of Exon 51 from human dystrophin mRNAs, carrying frame-shifting deletions adjacent to this exon, results in dystrophin expression. No major side-effects after local administration of the antisense oligomer were reported. Additional trials are underway, targeting the same exon but using an oligomer of different backbone chemistry. If functional dystrophin synthesis is demonstrated, and safety issues are addressed, subsequent trials will involve systemic delivery. Great challenges are ahead, some technical; establishing an effective delivery regimen, some ethical; choosing subsequent targets for therapy, and others of an administrative and regulatory nature.
Vascular Bed–specific Expression of an Endothelial Cell Gene Is Programmed by the Tissue Microenvironment (1997)

The endothelium is morphologically and functionally adapted to meet the unique demands of the underlying tissue. At the present time, little is known about the molecular basis of endothelial cell diversity. As one approach to this problem, we have chosen to study the mechanisms that govern differential expression of the endothelial cell-restricted von Willebrand factor (vWF) gene. Transgenic mice were generated with a fragment of the vWF gene containing 2,182 bp of 5' flanking sequence, the first exon and first intron coupled to the LacZ reporter gene. In multiple independent lines of mice, beta-galactosidase expression was detected within endothelial cells in the brain, heart, and skeletal muscle. In isogeneic transplantation models, LacZ expression in host-derived auricular blood vessels was specifically induced by the microenvironment of the heart. In in vitro coculture assays, expression of both the transgene and the endogenous vWF gene in cardiac microvascular endothelial cells (CMEC) was upregulated in the presence of cardiac myocytes. In contrast, endothelial cell levels of thrombomodulin protein and mRNA were unchanged by the addition of ventricular myocytes. Moreover, CMEC expression of vWF was not influenced by the addition of 3T3 fibroblasts or mouse hepatocytes. Taken together, the results suggest that the vWF gene is regulated by vascular bed-specific pathways in response to signals derived from the local microenvironment.
Functional Capabilities of a Computer Control System for Television Switching (1976)

The function of the NBC computer control system for television switching is to provide the overall execution and control necessary to support the production of several independent streams of program material. This function includes all program switching along with control of all video and audio sources in the NBC plant. The primary input to the control system is a magnetic tape prepared by NBC Management Information Systems which contains a daily routine describing the program material for the day — including channel (Local NBC, Network, Regional Networks), time of action, length of material, text describing the material, and the associated video and audio sources of the material. The requirement of continuous operation and system reliability dictated a multi-computer configuration to support the required central function. The configuration chosen consists of two different types of computer systems, called channel processors and keyboard processors. Channel systems carry out the switching of program material and facilities control for a single operator-specified channel; keyboard systems provide all command and bookkeeping functions. The discussion is complete to the level of individual tally lights.
Verotoxin Receptor Glycolipid in Human Renal Tissue (1989)

Infection with verotoxin producing Escherichia coli has been strongly implicated in the etiology of the hemolytic uremic syndrome (HUS). We have previously shown that this toxin specifically binds to a glycolipid receptor-globotriosyl ceramide (Gb3). We have therefore quantitated the level of this glycolipid by HPLC in human renal cortex and medulla as a function of age. We have also measured the binding of verotoxin to Gb3 isolated from each renal tissue sample. Gb3 was a major component of the glycolipid fraction of all renal samples analyzed. The levels were found to be higher in the cortex than medulla, correlating with the clinical incidence of renal lesions in HUS, but reduced in the kidneys of infants as compared to adults. Verotoxin binding was directly proportional to the renal Gb3 content. Thus, human renal tissue is a rich source of the verotoxin receptor glycolipid. However, changes in receptor concentration cannot explain the age-related incidence of HUS.
Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. (1995)

We demonstrated that the GCC box, which is an 11-bp sequence (TAAGAGCCGCC) conserved in the 5' upstream region of ethylene-inducible pathogenesis-related protein genes in Nicotiana spp and in some other plants, is the sequence that is essential for ethylene responsiveness when incorporated into a heterologous promoter. Competitive gel retardation assays showed DNA binding activities to be specific to the GCC box sequence in tobacco nuclear extracts. Four different cDNAs encoding DNA binding proteins specific for the GCC box sequence were isolated, and their products were designated ethylene-responsive element binding proteins (EREBPs). The deduced amino acid sequences of EREBPs exhibited no homology with those of known DNA binding proteins or transcription factors; neither did the deduced proteins contain a basic leucine zipper or zinc finger motif. The DNA binding domain was identified within a region of 59 amino acid residues that was common to all four deduced EREBPs. Regions highly homologous to the DNA binding domain of EREBPs were found in proteins deduced from the cDNAs of various plants, suggesting that this domain is evolutionarily conserved in plants. RNA gel blot analysis revealed that accumulation of mRNAs for EREBPs was induced by ethylene, but individual EREBPs exhibited different patterns of expression.
Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B (1989)

Inherited diseases might be treated by introducing normal genes into a patient's somatic tissues to correct the genetic defects. In the case of hemophilia resulting from a missing clotting factor, the required gene could be introduced into any cell as long as active factor reached the circulation. We previously showed that retroviral vectors can efficiently transfer genes into normal skin fibroblasts and that the infected cells can produce high levels of a therapeutic product in vitro. In the current study, we examined the ability of skin fibroblasts to secrete active clotting factor after infection with different retroviral vectors encoding human clotting factor IX. Normal human fibroblasts infected with one vector secreted greater than 3 micrograms factor IX/10(6) cells/24 h. Of this protein, greater than 70% was structurally and functionally indistinguishable from human factor IX derived from normal plasma. This suggests that infected autologous fibroblasts might provide therapeutic levels of factor IX if transplanted into patients suffering from hemophilia B. By transplanting normal diploid fibroblasts infected with the factor IX vectors, we showed that human factor IX can be produced and is circulated at readily detectable levels in rats and mice.
A 1.8 GHz CMOS voltage-controlled oscillator (2002)

This paper describes the factors that limit the tuning range of monolithic LC voltage-controlled oscillators (VCOs), especially at low supply voltages, and introduces circuit techniques that alleviate this problem. Incorporating such techniques, a 1.8 GHz CMOS oscillator achieves a tuning range of 120 MHz with a relatively constant gain while exhibiting a phase noise of -100 dBc/Hz at 500 kHz offset. The actual implementation is a quadrature generator consisting of two coupled oscillators. Since the two oscillators are identical, only one is considered here.
Human combinatorial antibody libraries to hepatitis B surface antigen. (1992)

Human antibody Fab fragments that bind to hepatitis B surface antigen (HBsAg) were generated by using a recombinant phage surface-display expression system. Characterization of HBsAg-specific Fab fragments isolated from two vaccinated individuals reveals diversity in specificity of antigen binding and in the sequences of the complementarity-determining region. The sequence results show examples of human light-chain promiscuity that result in fine specificity changes and a strong relationship to a human germ-line gene. This application illustrates further that this technique is a powerful tool to isolate distinct human antibodies against immunogenic viral targets.
[Methylation status of ZO-1 gene in patients with myelodysplastic syndrome]. (2008)

The objective of this study was to investigate the methylation status of zonula occluden protein-1 (ZO-1) gene in patients with myelodysplastic syndrome (MDS) and to identify its roles in pathogenesis, development and classification of MDS. 85 patients with MDS and 30 healthy individuals were tested by methylation specific polymerase chain reaction (MS-PCR). The results indicated that no ZO-1 promoter methylation could be detected in healthy controls. methylation of ZO-1 gene promoter of bone marrow was found in 56.5% (48/85) MDS patients. The difference between these two kinds of subjects was statistically significant (p<0.05). The methylation status of ZO-1 gene promoter region in the subtypes of MDS was as following: RA (18/37, 48.6%), RAS (4/6, 67%), RCMD (19/30, 63%), RAEB (7/12, 58%). Every subtype of MDS patients had statistical difference from healthy people (p<0.05), but between the subtypes of MDS there were no significant statistical differences in the methylation status of ZO-1 gene, while the level of ZO-1 promoter methylation in group of RA was lower than that in other groups. It is concluded that the ZO-1 promoter region in bone marrow of MDS patient shows a hypermethylation status, which is specific for MDS. MDS is a common hematologic malignancy with clonal proliferation, it is difficult to differentiate from many other hematologic malignancies in clinical diagnosis. However, the change of ZO-1 gene methylation status is closely related to pathogenesis of MDS, therefore the ZO-1 gene as valuable diagnostic marker has important clinical significance. The ZO-1 gene may be a potential gene related to hematologic malignancies.