gebhart/patrepeval huggingface dataset:
Tissue-Specific Expression and Promoter Analysis of the Tobacco ltp1 Gene (1996)

The Nicotiana tabacum Itp1 gene (Ntltp1) encodes a small basic protein that belongs to a class of putative lipid transfer proteins. These proteins transfer lipids between membranes in vitro, but their in vivo function remains hotly debated. This gene also serves as an important early marker for epidermis differentiation. We report here the analysis of the spatial and developmental activity of the Ntltp1 promoter, and we define a sequence element required for epidermis-specific expression. Transgenic plants were created containing 1346 bp of the Ntltp1 promoter fused upstream of the beta-glucuronidase (GUS) gene. In the mature aerial tissues, GUS activity was detected predominantly in the epidermis, whereas in younger aerial tissues, such as the shoot apical meristem and floral meristem, GUS expression was not restricted to the tunica layer. Unexpectedly, GUS activity was also detected in young roots particularly in the root epidermis. Furthermore, the Ntltp1 promoter displayed a tissue and developmental specific pattern of activity during germination. These results suggest that the Ntltp1 gene is highly expressed in regions of the plant that are vulnerable to pathogen attack and are thus consistent with the proposed function of lipid transfer proteins in plant defense. Deletions of the promoter from its 5' end revealed that the 148 bp preceding the translational start site are sufficient for epidermis-specific expression. Sequence comparison identified an eight-nucleotide palindromic sequence CTAGCTAG in the leader of Ntltp1, which is conserved in a number of other Itp genes. By gel retardation analysis, the presence of specific DNA-protein complexes in this region was demonstrated. The characterization of these factors may lead to the identification of factors that control early events in epidermis differentiation.
Satellite Based Seismic Technology Case Study – Berkine Basin, Algeria (2004)

EO32 SATELLITE BASED SEISMIC TECHNOLOGY CASE STUDY: BERKINE BASIN ALGERIA Summary 1 Landsat ASTER and ERS satellite data combined with ASTER derived digital elevation models (DEMs) have been used to analyze the surface and near-surface effects on seismic data quality in a dune covered region of the Berkine Basin in eastern Algeria. The study investigates two main features which impact on seismic quality at the acquisition and processing stages; the surface morphology and consolidation of sand dunes plus the presence of gypsiferous layers in the interdune areas. This paper demonstrates that the analysis of satellite imagery and digital elevation models
Separation of metallic and semiconducting single-walled carbon nanotubes through fluorous chemistry (2009)

Separation of metallic from semiconducting single-walled carbon nanotubes has been a major challenge for some time and some previous efforts have resulted in partial success. We have accomplished the separation effectively by employing fluorous chemistry wherein the diazonium salt of 4-heptadecafluorooc tylaniline selectively reacts with the metallic nanotubes present in the mixture of nanotubes. The resulting fluoroderivative was extracted in perfluorohexane leaving the semiconducting nanotubes in the aqueous layer. The products have been characterized by both Raman and electronic absorption spectroscopy. The method avoids the cumbersome centrifugation step required by some other procedures.
Treatment of Allergic Rhinitis: H1-Antihistamines and Intranasal Steroids (2002)

Allergic rhinitis is charterized as an inflammatory disease of the nasal mucosa. In clinical practice, H(1)-antihistamines and topical corticosteroids are most commonly used pharmacological agents for the treatment of allergic rhinitis. The beneficial effects of steroids depend upon their long-term anti-inflammatory effect rather than upon direct receptor antagonism. This is different to H(1)-antihistamines, which block both neural and vascular H(1) receptors and have a clinical effect on symptoms such as nasal itching, sneezing, and rhinorrhea. H(1)-antihistamines are rapidly absorbed and most of them are metabolized by the hepatic cytochrome P system and begin to reduce nasal symptoms (itching and sneezing) within one hour. Understanding of both the efficacy and the pharmacological properties of these commonly used drugs in the treatment of nasal allergic inflammation and its related nasal symptoms is very important. From a clinical viewpoint, it will provide a useful guideline for an appropriate use of these drugs.
Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis (1991)

The use of deoxyribonucleotide substitution in RNA (mixed RNA/DNA polymers) permits an evaluation of the role of 2'-hydroxyl groups in ribozyme catalysis. Specific deoxyribonucleotide substitution at G9 and A13 of the ribozyme decreases the catalytic activity (kcat) of the ribozyme by factors of 14 and 20, respectively. The reduction of the reaction rate concomitant with the absence of these 2'-OHs or the 2'-OH of the substrate U7 position can be partially compensated by increasing the Mg2+ concentration above 10 mM. The KMg of the all-RNA ribozyme is 5.3 mM, and the lack of either of the three influential 2'-OHs increases this value by a factor of approximately 3. These and other reaction constants for the ribozyme and the deoxy-substituted analogues have been determined by assuming a three-step mechanism. The data presented here provide the basis for the formulation of a molecular model of ribozyme activity.
Why should anyone care about computing with anyons? (2007)

In this article we present a pedagogical introduction of the main ideas and recent advances in the area of topological quantum computation. We give an overview of the concept of anyons and their exotic statistics, present various models that exhibit topological behaviour and establish their relation to quantum computation. Possible directions for the physical realization of topological systems and the detection of anyonic behaviour are elaborated.
Inflammatory Bowel Disease Revisited: Newer Drugs (1990)

The development of new drug therapy is an evolutionary process progressing from clinical success with current treatments through an understanding of interactions in the immune and inflammatory events that culminate in the tissue injury of IBD. The basic immunoinflammatory response is reviewed, with identification of the recognized and potential sites of activity of current therapies. Potential sites and implications for future interventions by newer therapies are discussed as we anticipate the discovery of the etiology and eventual cure for ulcerative colitis and Crohn's disease.
Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies. (1983)

The predominance of the relatively uncommon V region subgroup isotype kappa III among the light chains of human monoclonal (IgM kappa) anti-IgG antibodies, (i.e., rheumatoid factors), was further documented through sequence analyses of ten such autoantibodies isolated from IgM-anti-IgG cold-insoluble immune complexes (mixed cryoglobulins). The amino-terminal sequence of all ten kappa-chains was characteristic for kappa III proteins and virtually identical to that of a prototype kappa III light chain. Similar sequence identity was found for kappa-chains isolated from three IgM kappa autoantibodies that formed cold-insoluble immune complexes with low-density lipoprotein (LDL). The thirteen light chains were found to be virtually identical in sequence for the first framework region (FR); ten of these proteins sequenced through the first complementarity-determining region (CDR) and into the second FR were markedly similar. The second CDR of five proteins was almost identical in sequence to that of the prototype kappa III-chain. Concordance was also demonstrated between the structural classification of the light chains as kappa III and their immunochemical classification as members of this V region subgroup. Serologic analyses of light chains isolated from seven IgM kappa autoantibodies (six anti-IgG, one anti-LDL) and of one intact IgM kappa anti-LDL antibody showed that each had antigenic determinants common to kappa II proteins. These light chains also expressed the antigenic determinant(s) of a V-region sub-subgroup of kappa III proteins designated kappa IIIb. Our studies confirm the preferential association of kappa III (and kappa IIIb) light chains with IgM kappa anti-IgG antibodies and demonstrate a similar association for IgM kappa anti-LDL antibodies. The finding that these and other types of IgM kappa autoantibodies, e.g., cold agglutinins, have remarkably similar light chains suggests an inherent restriction in the immune response to self-antigens.
Antibodies to guanosine triphosphate misidentified as anti–double‐stranded DNA antibodies in a patient with antinuclear antibody–negative lupus, due to buckling of insolubilized assay DNA (2004)

A new problem in dsDNA ELISA is revealed in the occurrence of a hitherto-unknown and unusual buckling of the insolubilized DNA molecule, which, absent in dsDNA found in solution or in whole cells, presumably creates gaps of single-strandedness in the molecule. A new antibody specific for GTP is described in this patient, which may be clinically important.
Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides:  2‘-Amino- and 2‘-Thio-LNA Monomeric Nucleosides (1998)

ADVERTISEMENT RETURN TO ISSUECommunicationNEXTSynthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2'-Amino- and 2'-Thio-LNA Monomeric NucleosidesSanjay K. Singh, Ravindra Kumar, and Jesper WengelView Author Information Center for Synthetic Bioorganic Chemistry, Department of Chemistry, Chemical Laboratory II, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark Cite this: J. Org. Chem. 1998, 63, 18, 6078–6079Publication Date (Web):August 8, 1998Publication History Received13 April 1998Published online8 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/jo9806658https://doi.org/10.1021/jo9806658rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views885Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Biopolymers,Carbon,Conformation,Nucleic acids,Pyrimidine Get e-Alerts
Microbial Envelope Proteins Related to Iron (1982)

INTRODUCTION AND SCOPE ...... 285 THE VITAMIN BJ2 CONNECTION 289 THE ENVELOPE OF GRAM·NEGATIVE BACTERIA 289 FERRICHROME RECEPTOR 29 1 FERRIC ENTEROBACTIN RECEPTOR 293 FERRIC CITRATE RECEPTOR ..... 297 CITRATE-HYDROXAMATE SIDEROPHORES 297 TONB 299 AGROBA CTERIUM TUMEFA CIENS AND PARA COCCUS DENITRIFICANS 300 VIBRIO SPP. 301 PSEUDOMONAS SPP. . . ...... .... . ..... 301 NEISSERIA SPP. 302 EXPRESSION AND REGULATION 302 CONCLUSIONS 304
Proximiter: Enabling mobile proximity-based content sharing on portable devices (2009)

The recent years have witnessed an explosive amount of user-generated contents, along with users' soaring demands on sharing these contents. An evidence of that is the blossom of hundreds of sharing sites on the web, among which the most famous are MySpace [1], Flickr [2], YouTube [3], Facebook [4] and LinkedIn [5]. Through these sites, users upload the contents they generate (blogs, pictures, videos, resumes, etc.), and make them available to their friends or the general public. A common characteristic of such Internet-based content sharing scenarios is that all contents are hosted by third-party servers on the Internet, and sharing happens when content consumers (regardless of where they are) access the hosting web sites.
ABCNN: Attention-Based Convolutional Neural Network for Modeling Sentence Pairs (2015)

How to model a pair of sentences is a critical issue in many NLP tasks such as answer selection (AS), paraphrase identification (PI) and textual entailment (TE). Most prior work (i) deals with one individual task by fine-tuning a specific system; (ii) models each sentence's representation separately, rarely considering the impact of the other sentence; or (iii) relies fully on manually designed, task-specific linguistic features. This work presents a general Attention Based Convolutional Neural Network (ABCNN) for modeling a pair of sentences. We make three contributions. (i) ABCNN can be applied to a wide variety of tasks that require modeling of sentence pairs. (ii) We propose three attention schemes that integrate mutual influence between sentences into CNN; thus, the representation of each sentence takes into consideration its counterpart. These interdependent sentence pair representations are more powerful than isolated sentence representations. (iii) ABCNN achieves state-of-the-art performance on AS, PI and TE tasks.
Unstable heterozygosity in a diploid region of herpes simplex virus DNA (1984)

We have examined the behavior of a herpes simplex virus strain KOS isolate in which the two inverted repeats flanking the short segment of viral DNA differ in length by approximately 60 base pairs. We find that individual viral DNA molecules exist which contain the two distinguishable repeats, demonstrating that heterology between the repeats is tolerated. However, viruses heterozygous for the two different repeats are unstable, segregating both classes of homozygotes at a high frequency. We propose that this segregation is a consequence of the high-frequency recombination events which also result in genome segment inversion.
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2 (1999)

The ability of morphine to alleviate pain is mediated through a heterotrimeric guanine nucleotide binding protein (G protein)-coupled heptahelical receptor (GPCR), the mu opioid receptor (muOR). The efficiency of GPCR signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of the receptors by specific GPCR kinases and the subsequent interaction of the phosphorylated receptors with beta-arrestin 1 and beta-arrestin 2. Functional deletion of the beta-arrestin 2 gene in mice resulted in remarkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desensitization was impaired. These results provide evidence in vivo for the physiological importance of beta-arrestin 2 in regulating the function of a specific GPCR, the muOR. Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence.
INDUCTION OF ALTERED GLOBIN SYNTHESIS IN HUMAN IMMATURE ERYTHROCYTES INCUBATED WITH RIBONUCLEOPROTEIN (1962)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Generalized mosaicing: wide field of view multispectral imaging (2002)

We present an approach to significantly enhance the spectral resolution of imaging systems by generalizing image mosaicing. A filter transmitting spatially varying spectral bands is rigidly attached to a camera. As the system moves, it senses each scene point multiple times, each time in a different spectral band. This is an additional dimension of the generalized mosaic paradigm, which has demonstrated yielding high radiometric dynamic range images in a wide field of view, using a spatially varying density filter. The resulting mosaic represents the spectrum at each scene point. The image acquisition is as easy as in traditional image mosaics. We derive an efficient scene sampling rate, and use a registration method that accommodates the spatially varying properties of the filter. Using the data acquired by this method, we demonstrate scene rendering under different simulated illumination spectra. We are also able to infer information about the scene illumination. The approach was tested using a standard 8-bit black/white video camera and a fixed spatially varying spectral (interference) filter.
Increase of pulmonary artery occlusion pressure during upper airway obstruction in sleep apnea (1996)

From the Pulmonary Division, Department of Medicine, North Shore University Hospital, and the Department of Medicine, Cornell University Medical College, Manhasset, NY. Dr. Schnader was supported by an American Lung Association Research Grant. Address requests for reprints to: Jeff Schnader, MD, Pulmonary Division, North Shore University Hospital-Cornell University Medical College, 300 Community Drive, Manhasset, NY 11030.
Dapsone in the treatment of presumed brown recluse spider bite of the eyelid. (1985)

Brown recluse spider bites occur commonly in the Southern United States but eyelid bites are rare. Management of eyelid bites is difficult because the initial spider bite is frequently unnoticed, surgical and medical treatments are ineffective, and even a small area of necrosis affects the appearance and function of the eyelid.
RNA Molecules That Bind to and Inhibit the Active Site of a Tyrosine Phosphatase (1998)

Protein tyrosine phosphatases (PTPases) are essential proteins in many cellular processes. In vitro selection was used to evolve high affinity RNA aptamers to the Yersinia PTPase from two random pools varying in length. Selected aptamers from the two different pools share a 21-residue conserved sequence. They bind to their target with dissociation constants of 18 and 28 nM and inhibit the enzyme with IC50 values of 10 and 35 nM, but do not bind a related PTPase. Modification of the PTPase's active site cysteine with the alkylating agent iodoacetate results in a loss of binding affinity. These experiments suggest that the selected aptamers act by binding at or near the active site and might therefore be useful in defining the interactions between PTPases and their targets.
X-Ray and Scanning Electron Microscopic Analysis of the Structural Composition of Tear Ferns (1994)

Dried tears from keratoconjunctivitis sicca eyes fail to exhibit the fern-like crystallization patterns observed with tears from eyes with normal tear function. To test our hypothesis that the extent of ferning depends on the ratio of salts to protein and mucin in the tear sample, dried tears from six normal subjects were subjected to scanning electron microscopy (SEM) and X-ray analyses. X-ray diffraction identified sodium chloride and potassium chloride as the major components of tear fern crystals. X-ray fluorescence detected the elements potassium, chlorine, calcium, and sulfur in the dried tear samples, with sulfur indicating the presence of protein and/or mucin. As well as confirming the presence of cubic fern nuclei, SEM revealed two kinds of material, having crystalline and globular appearances, that are hypothesized to be composed of salts and protein/mucin, respectively. Globular material appeared to block extension of crystal fern arms or to coat crystalline material, but did not crystallize. These findings suggest that tear fern crystals are composed of sodium and potassium chloride, with proteinaceous material controlling crystallization indirectly by coating crystal faces and blocking fern extension. This structural composition is consistent with the hypothesis that the ratio of salt to macromolecular species is an important determinant of tear ferning.
Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells. (1994)

Translation of thymidylate synthase (TS) mRNA is controlled by its own protein product, TS, in an autoregulatory manner. Direct binding of TS protein to two different cis-acting elements on the TS mRNA is associated with this translational regulation. In this study, an immunoprecipitation-reverse transcription-PCR technique was used to identify a TS ribonucleoprotein (RNP) complex in cultured human colon cancer cells. Using antibodies specific for TS protein, we show that TS is complexed in vivo with its own TS RNA. Furthermore, evidence demonstrating a direct interaction between the mRNA of the nuclear oncogene c-myc and TS protein is presented.
Nomenclator descriptive query optimization for large X.500 environments (1991)

is an architecture for providing efficient descriptive (attribute-based) naming in a large internet environment.
Continuous-wave, high-power, Raman continuum generation in holey fibers (2003)

The possibility of using low pump power for cw Raman continuum generation is demonstrated by optimization of the pump peak power and by accounting for the loss-related reduction of the effective length of Raman interaction in holey fibers. A 3.8-W, 324-nm-wide cw Raman continuum with a spectral power density higher than 10 mW/nm is generated in a completely fiber-integrated, single-mode format.
Biological activity of region 65–102 of the myelin basic protein (1986)

Region 65-102 of the myelin basic protein (MBP) houses a number of antigenic determinants known to induce delayed-type hypersensitivity, experimental allergic encephalomyelitis (EAE), suppressor cell function, and antibodies. In this report we describe the biological activity of synthetic peptides S53, S55, and S49 with sequence homology to region 69-84 of the rat, guinea pig, and bovine MBP. Peptide S53-A, defined by residues 75-84 of the guinea pig (SQRSQDEN) and of the rat (SQRTQDEN) MBP induced clinical signs of disease in Lewis rats. These included weight loss, flaccid tail, "muscle wasting," and hind-leg weakness. Histological examination of brain, spinal cord, and sciatic nerve sections of diseased rats revealed the complete absence of focal and perivascular lymphocytic infiltrates characteristics of demyelinating EAE lesions. Elongation of peptide S53 by three or six residues to residue sequences naturally found at its N-terminal end gave rise to peptides S55S (PQKSQRSQDEN) and S49S (GSLPQKSQRSDQDEN), respectively. Lewis rats challenged with either S55S or S49S developed classical clinical and histological signs of EAE. Severe hind-leg paralysis was accompanied by incontinence and sometimes death. Injected in the form of carrier-free peptide, S53 was a meager B cell immunogen. S53 conjugated with methylated-bovine serum albumin was also a potent immunogen and produced clinical signs of disease without CNS pathology. By comparison, carrier-free S55S and S49S were potent immunogens giving rise to antibodies that cross reacted completely and competitively with S55S but considerably less so with S53. The results show that the sequence of S53 defines an epitope responsible for the formation of anti-S53 antibodies. Elongation of the S53 sequence at its N-terminal end generated an additional epitope which induced cell-mediated immunity responsible for the concomitant development of pathological signs of EAE. It may be concluded that the induction of classical signs of EAE requires specific and defined sequences capable of expressing both B cell and T cell functions.