gebhart/patrepeval huggingface dataset:
Overview of IBM zEnterprise 196 I/O subsystem with focus on new PCI Express infrastructure (2012)

IBM zEnterprise® 196 introduces a new input/output (I/O) s5ubsystem, including a new I/O drawer that is largely based on a greatly expanded exploitation of industry-standard high-volume PCI Express® (PCIe®) links and switches. The System z® qualities of reliability, availability, and serviceability (RAS) are preserved and enhanced by combining the PCIe RAS capabilities with new System z capabilities. PCIe ports connecting the processor book to the I/O drawer are provided by a new IBM-designed PCIe fan-out card. This fan-out card and its firmware (Licensed Internal Code) support both traditional System z I/O and new I/O paradigms. In the new PCIe I/O drawer, PCIe switches provide fan-out and the well-established System z I/O failover function referred to as redundant I/O interconnect. This is the third generation of the I/O drawer/cage to be used in System z platforms. The PCIe I/O drawer design is extremely compact and provides enhanced I/O port granularity and density. It has been designed to provide performance extendibility for future I/O advancements. Traditional I/O such as FICON®, Fibre Channel Protocol, and Ethernet are provided with enhanced functionality and are packaged in this new PCIe I/O drawer. The advent of this new infrastructure opens up the possibility of attaching native PCIe adapters while allowing them to be controlled by system firmware or by the operating systems directly.
Shadow and rhythm as sign patterns of obstacle detection (2002)

For the navigation of the mobile robot, real time detection methods of moving vehicles and pedestrians are proposed. The method is based on a locomotion strategy, 'sign pattern-based stereotyped motion'. Sign patterns of a moving vehicle is shadow underneath the vehicle which is darker than any stain of the asphalt paved road. The sign pattern of pedestrian is rhythm of walking. Rhythm of walking is unique to the pedestrians, and not influenced by time, weather, sunlight, shadow and distance, moreover it is independent of the clothes the pedestrian puts on.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inter-rack live migration of multiple virtual machines (2012)

Within datacenters, often multiple virtual machines (VMs) need to be live migrated simultaneously for various reasons such as maintenance, power savings, and load balancing. Such mass simultaneous live migration of multiple VMs can trigger large data transfers across the core network links and switches, and negatively affect the cluster-wide performance of network-bound applications. In this paper, we present a distributed system for inter-rack live migration (IRLM), i.e., parallel live migration of multiple VMs across racks. The key performance objective of IRLM is to reduce the traffic load on the core network links during mass VM migration through distributed deduplication of VMs' memory images. We present an initial prototype of IRLM that migrates multiple QEMU/KVM VMs within a Gigabit Ethernet cluster with 10GigE core links. We also present preliminary evaluation on a small testbed having 6 hosts per rack and 4 VMs per host. Our evaluations show that, compared to the default live migration technique in QEMU/KVM, IRLM reduces the network traffic on core links by up to 44% and the total migration time by up to 26%. We also demonstrate that network-bound applications experience a smaller degradation during migration using IRLM.
Angus M'diarmid (1965)

Angus M'diarmid J. Ss. J. Ss. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s3-VII, Issue 172, 15 April 1865, Pages 305–306, https://doi.org/10.1093/nq/s3-VII.172.305-c Published: 15 April 1965
Multi-Wavelength Mid-Infrared Micro-Spectral Imaging Using Semiconductor Lasers (2003)

Infrared (IR, 3-12-microm) microscopic spectral imaging is an important analytical technique. Many current instruments employ thermal IR light sources, which suffer the problem of low brightness and high noise. This paper evaluates the system engineering merit in using semiconductor lasers, which offer orders-of-magnitude-higher power, brightness, and lower noise. A microscopic spectral imaging system using semiconductor lasers (quantum cascade) as illuminators, and focal plane array detectors demonstrated a high signal-to-noise ratio (> 20 dB) at video frame rate for a large illuminated area. The comparative advantages of laser vs. thermal light source are analyzed and demonstrated. Microscopic spectral imaging with fixed-wavelength and tunable lasers of 4.6-, 5.1-, 6-, and 9.3-microm wavelength was applied to a number of representative samples that consist of biological tissues (plant and animal), solid material (a stack of laminated polymers), and liquid chemical (benzene). Transmission spectral images with approximately 30-dB dynamic range were obtained with clear evidence of spectral features for different samples. The potential of more advanced systems with a wide coverage of spectral bands is discussed.
Novel long‐acting bronchodilators for COPD and asthma (2008)

An important step in simplifying asthma and chronic obstructive pulmonary disease (COPD) management and improving adherence with prescribed therapy is to reduce the dose frequency to the minimum necessary to maintain disease control. Therefore, the incorporation of once-daily dose administration is an important strategy to improve adherence and is a regimen preferred by most patients, which may also lead to enhancement of compliance, and may have advantages leading to improved overall clinical outcomes. Once-daily beta2-agonists or ultra long-acting beta2-agonists (LABAs) such as carmoterol, indacaterol, GSK-159797, GSK-597901, GSK-159802, GSK-642444 and GSK-678007 are under development for the treatment of asthma and COPD. Also some new long-acting antimuscarinic agents (LAMAs) such as aclidinium, LAS-35201, GSK656398, GSK233705, NVA-237 (glycopyrrolate) and OrM3 are under development. In any case, the current opinion is that it will be advantageous to develop inhalers containing combination of several classes of long-acting bronchodilator drugs in an attempt to simplify treatment regimens as much as possible. Consequently, several options for once-daily dual-action ultra LABA+LAMA combination products are currently being evaluated. A different approach is to have a dimer molecule in which both pharmacologies are present (these molecules are known as M3 antagonist-beta2 agonist (MABA) bronchodilators). The advent of a successful MABA product will revolutionize the field and open the door for a new range of combination products.
The Ethics of Processing (1993)

There are a number of sections and phrases in the Society of American Archivists's 1992 "Code of Ethics for Archivists" which can help explain issues and try to answer questions related to ethical issues in arrangement and description. These are among the many professional considerations which must weigh into the way in which an archivist administers both processing and an overall archival program.
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. (1994)

Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity. Oligonucleotides from the ALDA, PGK1, enolase 1, lactate dehydrogenase A, and phosphofructokinase L (PFKL) genes, containing sequences similar to the HIF-1 binding site in the erythropoietin enhancer, specifically bound HIF-1 present in crude nuclear extracts or affinity-purified preparations. Sequences from the ALDA, PFKL, and PGK1 genes containing HIF-1 binding sites mediated hypoxia-inducible transcription in transient expression assays. These results support the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis.
Performance evaluation of MIMO systems using dual-polarized antennas (2003)

Exploiting the radio channel in mobile communications systems in a multiple-input multiple-output (MIMO) manner has been shown to highly increase the system capacity. The access to such a MIMO channel usually involves spatially separated antennas of the same polarization at the transmitter and the receiver side. In this paper, we focus on the potential of dual-polarized antennas in mobile radio systems, which avoid undesired antenna spacings and promise increased system performance for certain environments. Therefore, a channel model is presented for data transmission over Ricean fading channels using antenna arrays with spatially separated antenna elements of the same polarization and spatially separated dual-polarized antenna elements, respectively. The performance of these MIMO channels is evaluated based on multiplexing data streams over the available antenna branches and a joint detection of these data streams at the receiver.
Perioperative immune responses in cancer patients undergoing digestive surgeries (2009)

Patients with malignancy showed an abnormal perioperative Th1/Th2 balance suggesting predominance of a type-2 immune response. Major abdominal surgeries induce a marked shift in Th1/Th2 balance toward Th2 in the early postoperative stage.
Fractal capacitors (1998)

A linear capacitor structure using fractal geometries is described. This capacitor exploits both lateral and vertical electric fields to increase the capacitance per unit area. Compared to standard parallel-plate capacitors, the parasitic bottom-plate capacitance is reduced. Unlike conventional metal-to-metal capacitors, the capacitance density increases with technology scaling. A classic fractal structure is implemented with 0.6-/spl mu/m metal spacing, and a factor of 2.3 increase in the capacitance per unit area is observed. It is shown that capacitance boost factors in excess of ten may be possible as technology continues to scale. A computer-aided-design tool to automatically generate and analyze custom fractal layouts has been developed.
In Vivo Magnetic Resonance Imaging of Mesenchymal Stem Cells in Myocardial Infarction (2003)

MRI tracking of MSCs is feasible and represents a preferred method for studying the engraftment of MSCs in MI.
Phase-Change Behavior of Stoichiometric Ge[sub 2]Sb[sub 2]Te[sub 5] in Phase-Change Random Access Memory (2007)

We observed the atomic structures for each reset and set state in a phase-change random access memory fabricated using stoichiometric crystalline Ge2Sb2Te5. The reset state clearly showed a mixture of dome-shaped amorphous and crystal structure surrounding amorphous, but the set state showed abnormally grown large grains due to recrystallization of the amorphous structure. The crystal structure of the recrystallized grain was face-centered cubic. The element analysis indicated that the atomic composition changes to nonstoichiometric phase in the active regions of the reset and the set state, which is Sb-rich and Te-deficient compared to the pristine stoichiometric composition. Analysis showed that thermal interdiffusion of Sb and Te caused nonstoichiometric nature of the material to reach the energetically stable state in the active region.
Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor (1987)

Epidermal growth factor (EGF) is a potent polypeptide mitogen originally isolated from the adult male mouse submaxillary gland. It also acts as a gastrointestinal hormone. EGF-immunoreactive material has recently been identified within neuronal fibers and terminals in rodent brain. In the present study, EGF was found to enhance survival and process outgrowth of primary cultures of subneocortical telencephalic neurons of neonatal rat brain in a dose-dependent manner. This effect was observed with EGF concentrations as low as 100 picograms per milliliter (0.016 nanomolar) and was dependent on the continuous presence of EGF in the medium. Similar effects were observed with basic fibroblast growth factor, but several other growth-promoting substances, including other mitogens for glial elements, were without effect. Thus EGF, in addition to its mitogenic and hormonal activities, may act as a neurite elongation and maintenance factor for select neurons of the rodent central nervous system.
Effects of Surrounding Atmosphere on Micro-hardness and Tribological Properties of Sintered Alumina (1998)

Using a nano-indentation technique, the environmental effects were studied on the micro-hardness of sintered alumina. Friction and wear properties were also examined under lubrication with the same liquids: pH adjusted water solutions with NaOH or HCl, methanol, acetone, benzene and n-hexane. There were observed relationship between the wear properties and the hardness changes in organic compound liquids. It is considered that the adsorption phenomena dominate these environmental effects. On the other hands, there were observed few differences in the micro-hardness due to the change of the pH values. The friction and wear properties, however, showed obvious variation against the pH values. It is considered that the change of pH values affects dissolvable properties of the sliding surface.
Intervertebral Disk Degeneration Related to Reduced Vertebral Marrow Perfusion at Dynamic Contrast-Enhanced MRI (2009)

After normalization, lumbar vertebral marrow perfusion correlated well with intervertebral disk degeneration evaluated with dynamic contrast-enhanced MRI. Blood perfusion was 14% less in the vertebral body marrow between two degenerated disks than in vertebral marrow between two normal disks.
T lymphocyte and monocyte interaction by CD40 / CD40 ligand facilitates a lymphoproliferative response and killing of Cryptococcus neoformans in vitro (2000)

This study explored the role of CD40 / CD40 ligand (CD40L) in the induction of a lymphoproliferative response and killing of Cryptococcus neoformans in vitro. In our experimental system, monocytes exposed to C. neoformans were used as antigen-presenting cells (APC) and co-cultured with autologous T cells. The results showed that CD40 / CD40L strongly regulated the blastogenic response of T cells to C. neoformans. The fungus up-regulated CD40 expression on APC. An acapsular strain appeared to be a better inducer than an encapsulated strain. Time course experiments showed optimal regulation of CD40 expression at 48 h of incubation. Blocking the interaction of CD40 on APC with CD40L on T cells using mAb to CD40L resulted in a significant inhibition of IFN-γ production. The anti-cryptococcal activity of monocytes was greatly influenced by the CD40 / CD40L interaction, and a positive correlation was found between nitric oxide secretion and enhanced killing of C. neoformans. Finally, the CD40 / CD40L interaction was critical for induction of optimal secretion of pro-inflammatory cytokines such as TNF-α and IL-1β. These results indicate an important role for CD40 / CD40L interaction in inducing activation of T cells. Such cell-to-cell contact promotes anti-cryptococcal activity as well as secretion of pro-inflammatory cytokines by monocytes.
Applying ergonomics (1990)

Abstract When applying ergonomics it is necessary for an occupational health service to take problems seriously and to listen to the various groups responsible for working conditions. Second, it is essential for top management to make conscious decisions. Third, it is important to maintain contacts with those implementing the recommendations and to provide instructions for the people directly involved.
Efficient Synthesis of Fluoren-9-ones by the Palladium-Catalyzed Annulation of Arynes by 2-Haloarenecarboxaldehydes (2008)

Fluoren-9-ones and derivatives are readily prepared in good yields by the annulation of in situ generated arynes by 2-haloarenecarboxaldehydes in the presence of a palladium catalyst.
Immunization against influenza. Prevention of illness in man by aerosolized inactivated vaccine (1969)

During the A2 influenza epidemic of the winter of 1967 to 1968, commercially available inactivated influenza virus vaccine, bivalent, was administered by aerosol to 386 volunteers to test its efficacy in protecting against influenza illness. The illness rate in volunteers receiving the aerosolized vaccine was compared to that of 269 persons receiving the same vaccine subcutaneously and to that of 1,490 persons who received either sodium chloride solution or no inoculation. The group receiving aerosolized influenza vaccine had 79% fewer illnesses while subcutaneously immunized volunteers had 27% fewer illnesses, when compared to the control groups receiving no immunization. In addition to its superiority in ability to protect against naturally occurring influenza illness, the aerosolized vaccine led to a significantly lower incidence of side effects and to a significantly shorter duration of illness in those few who became ill.
Sensory circumventricular organs and brain homeostatic pathways (1993)

Circumventricular organs (CVOs), small structures bordering the ventricular spaces in the midline of the brain, have common morphological and endocrine-like characteristics that distinguish them from the rest of the nervous system. Among their unique features are cellular contacts with two fluid phases--blood and cerebrospinal fluid--and neural connections with strategic nuclei establishing circuitry for communications throughout the neuraxis. A variety of additional morphological and functional characteristics of the CVOs implicates this group of structures in a wide array of homeostatic processes. For three of the circumventricular organs--the subfornical organ (SFO), the organum vasculosum of the lamina terminalis (OVLT), and the area postrema (AP)--recent findings demonstrate these structures as targets for blood-borne information reaching the brain. We propose that these three sensory CVOs interact with other nuclei in the maintenance of several homeostatic processes by way of neural and humoral links. We emphasize the collective role of brain CVOs in the maintenance of body fluid homeostasis as a model for the functional integration of these fascinating "windows of the brain" within central neurohumoral systems.
Cyanine dye labeling reagents containing isothiocyanate groups (1989)

New isothiocyanate derivatives of cyanine dyes were synthesized as fluorescent covalent labeling reagents for proteins and other biomolecules. These dyes have maximum absorbance in the red and near infrared regions of the spectrum, have high extinction coefficients and have adequate quantum yields. Incorporating two alkyl sulfonate groups in the dye structures increases their water solubility, which is beneficial for labeling biological molecules in aqueous solution. Reactivities of proteins with these new cyanines are similar to their reactivities with fluorescein isothiocyanate. These new labeling reagents are complementary to the fluorescein and rhodamine reagents, expanding the possibilities of multicolor analyses. Sheep anti-mouse-IgG antibody was labeled with a pentamethine cyanine dye (CY5.8-ITC) and used with a fluoresceinated antibody as a second reagent for detecting human T-cell subsets by flow cytometry.
Binding of psoralen derivatives to DNA and chromatin: influence of the ionic environment on dark binding and photoreactivity (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of psoralen derivatives to DNA and chromatin: influence of the ionic environment on dark binding and photoreactivityJohn E. Hyde and John E. HearstCite this: Biochemistry 1978, 17, 7, 1251–1257Publication Date (Print):April 4, 1978Publication History Published online1 May 2002Published inissue 4 April 1978https://pubs.acs.org/doi/10.1021/bi00600a019https://doi.org/10.1021/bi00600a019research-articleACS PublicationsRequest reuse permissionsArticle Views136Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Methods for egg counts and larval cultures for strongyles infesting the gastro-intestinal tract of cattle (1950)

The method for egg counts is a modification of the Whitlock-Gordon technique for sheep strongyles and has been developed for low-plane infestations. It uses a three-gram faecal sample and an egg-counting slide of four 0.5-ml. cells. Satisfactory larval cultures are obtained by mixing dry, sterile cattle dung with the fresh faeces. A modified Baermann technique is used for recovering larvae from cultures.
Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects (2005)

The effects of chelating drugs used clinically as antidotes to metal toxicity are reviewed. Human exposure to a number of metals such as lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel and platinum may lead to toxic effects, which are different for each metal. Similarly the pharmacokinetic data, clinical use and adverse effects of most of the chelating drugs used in human metal poisoning are also different for each chelating drug. The chelating drugs with worldwide application are dimercaprol (BAL), succimer (meso-DMSA), unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa(2)EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa(3)DTPA, ZnNa(3)DTPA), deferoxamine (DFO), deferiprone (L1), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects. These include three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), the derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA) and the carbodithioates. Many factors have been shown to affect the efficacy of the chelation treatment in metal poisoning. Within this context it has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age. These findings may have a bearing in the design of new therapeutic chelation protocols for metal toxicity.
Protein complexes studied by NMR spectroscopy (1996)

Recent advances in NMR methods now allow protein complexes to be studied in great detail in a wide range of solution conditions. Isotope-enrichment strategies, resonance-assignment approaches and structural-determination methods have evolved to the point where almost any type of complex involving proteins of reasonable size may be studied in a straightforward way. A variety of isotope editing and filtering strategies underlie these powerful methodologies. Approaches to the characterization of the dynamics of protein complexes have also matured to the point where detailed studies of the effects of complexation on dynamics can be studied over a wide range of timescales.