gebhart/patrepeval huggingface dataset:
Identification of a Novel Prostate Tumor Target, Mindin/RG-1, for Antibody-Based Radiotherapy of Prostate Cancer (2005)

Gene expression analysis showed that a human mindin homologue, mindin/RG-1, is expressed selectively in prostate tissues and that its expression level is elevated in some prostate tumors. Mindin/RG-1 protein expression is maintained in >80% of prostate cancers metastatic to bone or lymph nodes as well as in locally recurrent tumors in androgen-unresponsive patients. In contrast, mindin/RG-1 expression in other normal tissues is significantly lower than that seen in the prostate. A fully human antibody, 19G9, was generated against mindin/RG-1 protein and was shown to accumulate at high abundance in LNCaP tumor xenografts. Conjugates of this antibody with the chelator CHX-A''-DTPA were generated and radiolabeled with either 111In, 90Y, or 86Y. Small animal positron emission tomography imaging with the 86Y-radiolabeled conjugate showed very specific accumulation of the antibody in LNCaP tumor xenografts with clear tumor delineation apparent at 4 hours. The therapeutic efficacy of [90Y]-CHX-A''-DTPA-19G9 was evaluated in mice bearing LNCaP xenografts. A dose-finding study identified a nontoxic therapeutic dose to be approximately 75 microCi. Significant antitumor effects were seen with a single administration of radiolabeled antibody to animals bearing 200 to 400 mm3 tumors. Inhibition of tumor growth was observed in all treated animals over a 49-day period. At 49 days posttreatment, slow tumor growth recurred but this could be prevented for an additional 40-day period by a second administration of a 75 microCi dose at day 49. We conclude that [90Y]-CHX-A''-DTPA-19G9 is a novel antibody conjugate that has considerable promise for therapy of metastatic prostate cancer in androgen-unresponsive patients.
CHARACTERIZATION OF POLYBUTYLACRYLATE-B-POLYVINYLPYRIDINE BLOCK COPOLYMERS BY SIZE-EXCLUSION CHROMATOGRAPHY AND DUAL REFRACTIVE INDEX/UV-DETECTION (2010)

An efficient and reliable size exclusion chromatographic (SEC) method has been developed allowing satisfactory insight into distribution of both molecular weight of polybutylacrylate-b-polyvinylpyridine (PBA-b-PVP) block copolymers as well as the relative amount of polyvinylpyridine (PVP) versus polybutylacrylate (PBA) along the molecular weight axis. This aim was accomplished by SEC using a rather new polyester-based GRAM stationary phase support of intermediate polarity and a polar eluent system of N,N-dimethylacetamide containing small amounts of lithium bromide and acetic acid for extensive suppression of adsorptive solute-stationary phase interactions.
Current issues in allogeneic stem cell transplantation (2005)

Hematopoietic stem cell transplantation (SCT) has evolved as a central treatment modality in the management of different hematological malignancies. However, 2 major issues still impact overall mortality and morbidity post transplant.Despite adequate post-transplantation immunosuppressive therapy, acute graft-versus-host disease (GvHD) remains a major cause of morbidity and mortality in the hematopoietic stem cell transplantation setting, even in patients who receive human HLA identical sibling grafts. Up to 30% of the recipients of stem cells or bone marrow transplantation from HLA-identical related donors and most patients who receive cells from other sources (matched-unrelated, non-HLA-identical siblings, cord blood) will develop Grade II or more acute GvHD despite immunosuppressive prophylaxis. Thus, GVHD continues to be a major limitation to successful hematopoietic stem cell transplantation.With improvements in outcome, an increasing number of patients survive free of the disease for which they were treated. Today, about 60% of patients will survive 5 years after diagnosis. Therefore, immediate survival is no longer the sole concern. The aim of the allogeneic SCT now is to cure a patient's underlying disease and, at the same time, to minimize the incidence of post-treatment complications and ensure the best possible long term quality of life. The long time span between initial therapy and late effects, the multiple factors influencing cancer related health risk and the unknown effect of treatment on aging are common characteristics of late effects. While the treatment strategy of a cancer patient depends widely on the type and extension of the disease, considerations for a long term survivor depend much more on the type of treatment applied, age of the patient, its general health status, as well as his familial and social integration.I will discuss, based on the most recent knowledge, advances and current issues in GvHD and some typical examples of late effects in survivors, and the practical recommendations that could assist practitioner and patient decision about appropriate healthcare for specific clinical circumstances.
Translating Ramp V˙O2 into Constant Power Output: A Novel Strategy that Minds the Gap (2020)

This study confirmed that a simple mean response time correction works for PO selection in the moderate-intensity but not in the heavy-intensity domain. A novel strategy was tested and validated to accurately prescribe a constant PO based on the RI V˙O2 response in a population of young healthy men.
Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides (1993)

Angiotensin I-converting enzyme (ACE, E.C.3.4.15.1) has been recently shown to contain two very similar domains, each of which bears a functional active site hydrolyzing Hip-His-Leu or angiotensin I (AI). The substrate specificity of the two active sites of ACE was compared using wild-type recombinant ACE and mutants, where one active site is suppressed by deletion or inactivated by mutations of 2 histidines coordinating an essential zinc atom. Both active sites converted bradykinin (BK) to BK1-7 and BK1-5 with similar kinetics and with Kappm at least 30 times lower and kcat/kappm 10 times higher than for AI. The carboxyl-terminal active site, but not the amino-terminal site, was activated by chloride; however, chloride activation was minimal compared with AI. Both domains also hydrolyzed substance P and cleaved a carboxyl-terminal protected dipeptide and tripeptide. The carboxyl-terminal active site was more readily activated by chloride and hydrolyzed substance P faster. Luteinizing-hormone releasing hormone was hydrolyzed by both active sites, but hydrolysis by the amino-terminal active site was faster. It performed the endoproteolytic amino-terminal cleavage of this peptide at least 30 times faster than the carboxyl-terminal active site. Both active sites cleaved a carboxyl-terminal tripeptide from luteinizing hormone-releasing hormone. Thus, both active sites of ACE possess dipeptidyl carboxypeptidase and endopeptidase activities. However, only the carboxyl-terminal active site can undergo a chloride-induced alteration that greatly enhances the hydrolysis of AI or substance P, and the amino-terminal active site possesses an unusual amino-terminal endoproteolytic specificity for a natural peptide. This suggests physiologically important differences between the subsites of the two active centers, and different substrate specificity, despite the high degree of sequence homology.
Dietary ω-3 Fatty Acid and Fish Intake and Incident Age-Related Macular Degeneration in Women (2011)

These prospective data from a large cohort of female health professionals without a diagnosis of AMD at baseline indicate that regular consumption of docosahexaenoic acid and eicosapentaenoic acid and fish was associated with a significantly decreased risk of incident AMD and may be of benefit in primary prevention of AMD.
A Single Dominant Gene Can Account for Eye Tracking Dysfunctions and Schizophrenia in Offspring of Discordant Twins (1988)

Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.
Implementation of a DSP-controlled photovoltaic system with peak power tracking (1998)

Photovoltaic systems normally use a maximum power point tracking (MPPT) technique to continuously deliver the highest possible power to the load when variations in the insulation and temperature occur. It overcomes the problem of mismatch between the solar arrays and the given load. A simple method of tracking the maximum power points (MPPs) and forcing the system to operate close to these points is presented. The principle of energy conservation is used to derive the large- and small-signal model and transfer function. By using the proposed model, the drawbacks of the state-space-averaging method can be overcome. The TI320C25 digital signal processor (DSP) was used to implement the proposed MPPT controller, which controls the DC/DC converter in the photovoltaic system. Simulations and experimental results show excellent performance.
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling (2014)

The increased cap-independent translation of anti-apoptotic proteins is involved in the development of drug resistance in lung cancer but signalling events regulating this are poorly understood. Fibroblast growth factor 2 (FGF-2) signalling-induced S6 kinase 2 (S6K2) activation is necessary, but the downstream mediator(s) coupling this kinase to the translational response is unknown. Here, we show that S6K2 binds and phosphorylates hnRNPA1 on novel Ser4/6 sites, increasing its association with BCL-XL and XIAP mRNAs to promote their nuclear export. In the cytoplasm, phosphoS4/6-hnRNPA1 dissociates from these mRNAs de-repressing their IRES-mediated translation. This correlates with the phosphorylation-dependent association of hnRNPA1 with 14-3-3 leading to hnRNPA1 sumoylation on K183 and its re-import into the nucleus. A non-phosphorylatible, S4/6A mutant prevented these processes, hindering the pro-survival activity of FGF-2/S6K2 signalling. Interestingly, immunohistochemical staining of lung and breast cancer tissue samples demonstrated that increased S6K2 expression correlates with decreased cytoplasmic hnRNPA1 and increased BCL-XL expression. In short, phosphorylation on novel N-term sites of hnRNPA1 promotes translation of anti-apoptotic proteins and is indispensable for the pro-survival effects of FGF-2.
Influence of sugars on the foliar uptake of bentazone and glyphosate (2002)

The effect of sugars on the uptake of bentazone and glyphosate into bean (Vicia faba) and wheat (Triticum aestivum) foliage was studied The addition of 05 glucose or sucrose significantly increased the uptake of bentazone into bean and wheat leaves This effect was also observed in the presence of a surfactant especially in wheat Glucose and sucrose also improved the uptake of glyphosate into wheat leaves especially in combination with surfactants of low ethylene oxide content When used at 2 concentration both sugars completely overcame the antagonistic effect of an organosilicone surfactant (Silwet L77) on glyphosate uptake into wheat leaves The results are discussed in relation to the solute dose on the leaf surface as influenced by surfactants and sugars
Variable rate speech coding with online segmentation and fast algebraic codes (2002)

In several speech coding applications the constraint of fixed bit rate and frame size is not imposed. For such a situation, a speech coding system performing speech segmentation and segment coding, both with reasonable complexity, is proposed. Speech is segmented according to its statistical properties. Each class of segment is encoded by a specific algorithm using algebraic excitation codebooks. An average bit rate between 5 and 6 kb/s yields a small degradation over a 9.6-kb/s fixed rate coder.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of the flow cytometer stain Hoechst 33342 on human spermatozoa (1996)

Several procedures exist for processing sperm cells for sex preselection. Flow cytometric separation using the fluorochrome stain Hoechst 33342, chemically known as bisbenzimide, is the most promising. The objective of this study was to determine the effect of bisbenzimide on spermatozoa assessed by means of the sperm survival test and to analyse the beta-globin gene in sperm DNA after exposure to increasing concentrations of bisbenzimide. Donor (n = 16) sperm specimens were pooled and washed in a discontinuous Percoll gradient 95:47%, divided and incubated in tubes containing bisbenzimide at concentrations 0 (control), 0.9, 9, 90, 900 and 9000 microM at 25 degrees C and scanned on a computer-aided sperm motility analyser at 0, 1, 4 and 24 h. Spermatozoa were also incubated in a known mutagen, ethidium bromide, as positive control. After 24 h of incubation, the treated sperm cells were processed through DNA extraction and polymerase chain reaction (PCR) performed with primers targeting the beta-globin gene. The amplified DNA products were analysed for evidence of mutation in 5% polyacrylamide gel electrophoresis and 20:80 denaturing gradient gel electrophoresis (DGGE) and further confirmed in 30:40 DGGE. The results showed complete cessation of motility in sperm incubated in the presence of 900 microM or higher concentrations of bisbenzimide. The beat cross frequency sperm parameter was significantly different at the 90 microM or higher concentration of bisbenzimide compared with the control. At concentrations < 900 microM bisbenzimide, there were no differences in the remaining sperm kinematic parameters (percentage rapid progressive, percentage total progressive, sperm velocities, linearity, straightness, amplitude of lateral head displacement and percentage hyperactive motility). PCR and DGGE analyses of spermatozoa treated with bisbenzimide showed no evidence of mutation in the representative region of the beta-globin gene at concentrations < 900 microM. The data suggest an inhibitory effect of bisbenzimide on human sperm motility at 900 microM or higher concentrations of bisbenzimide. The decrease in sperm motility and rapid progression were not due to changes in pH. Point mutation in the representative region of the beta-globin gene in human spermatozoa was detected only at high concentrations (> or = 900 microM) of bisbenzimide. The data suggest that incubating sperm in low concentrations of bisbenzimide (< 90 microM) for up to 24 h does not significantly affect all the sperm kinematic parameters including the beat cross frequency parameter when compared with the control.
l-Sce III: a novel group I intron-encoded endonuclease from the yeast mitochondria (1993)

Journal Article l-Sce III: a novel group I intron-encoded endonuclease from the yeast mitochondria Get access J. Perea, J. Perea Laboratoire de Genetique MoleculaireCNRS URA 1302, Ecole Normale Superieure, 46 rue d'Ulm, 75230 Paris cedex 05, France Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Desdouets, C. Desdouets Laboratoire de Genetique MoleculaireCNRS URA 1302, Ecole Normale Superieure, 46 rue d'Ulm, 75230 Paris cedex 05, France Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Schapira, M. Schapira Laboratoire de Genetique MoleculaireCNRS URA 1302, Ecole Normale Superieure, 46 rue d'Ulm, 75230 Paris cedex 05, France Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Jacq C. Jacq * Laboratoire de Genetique MoleculaireCNRS URA 1302, Ecole Normale Superieure, 46 rue d'Ulm, 75230 Paris cedex 05, France *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 21, Issue 2, 25 January 1993, Page 358, https://doi.org/10.1093/nar/21.2.358 Published: 25 January 1993 Article history Received: 20 October 1992 Accepted: 12 December 1992 Published: 25 January 1993
High-Voltage GaAs Photovoltaic Laser Power Converters (2009)

The main drawback of photovoltaic (PV) laser power converters based on GaAs material is the low output voltage, which is often insufficient to power electronic circuits directly. Aside from the use of a dc-dc converter in combination with a single PV converter, it is possible to boost the voltage by the monolithic serial interconnection of several converter segments on a single chip, often called multiple converters. Another novel approach introduced in this paper is a multijunction PV cell, where several subcells of the same material are stacked onto a substrate and interconnected by interband tunnel diodes. This paper explores a tandem GaAs-GaAs converter and compares the results with a 2-V multiple PV converter under monochromatic laser illumination. In addition, 4-V multiple PV converters with maximum monochromatic efficiencies (810 nm) of up to 50.1% at 51.6 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 6-V converters are investigated. Thereby, the fabrication technology of the devices is outlined and the influence of inhomogeneous illumination on the performance of these energy converters is discussed.
Event Detection, Query, and Retrieval for Video Surveillance (2009)

Video surveillance automation is used in two key modes: watching for known threats in real-time and searching for events of interest after the fact. Typically, real-time alerting is a localized function, for example, an airport security center receives and reacts to a “perimeter breach alert,” while investigations often tend to encompass a large number of geographically distributed cameras like the London bombing, or Washington sniper incidents. Enabling effective event detection, query and retrieval of surveillance video for preemption, and investigation, involves indexing the video along multiple dimensions. This chapter presents a framework for event detection and surveillance search that includes: video parsing, indexing, query and retrieval mechanisms. It explores video parsing techniques that automatically extract index data from video indexing, which stores data in relational tables; retrieval which uses SQL queries to retrieve events of interest and the software architecture that integrates these technologies.
SHIP1 Regulates MSC Numbers and Their Osteolineage Commitment by Limiting Induction of the PI3K/Akt/β-Catenin/Id2 Axis (2014)

Here, we show that Src homology 2-domain-containing inositol 5'-phosphatase 1 (SHIP1) is required for the efficient development of osteoblasts from mesenchymal stem cells (MSCs) such that bone growth and density are reduced in mice that lack SHIP1 expression in MSCs. We find that SHIP1 promotes the osteogenic output of MSCs by limiting activation of the PI3K/Akt/β-catenin pathway required for induction of the MSC stemness factor Id2. In parallel, we demonstrate that mice with myeloid-restricted ablation of SHIP1, including osteoclasts (OCs), show no reduction in bone mass or density. Hence, diminished bone mass and density in the SHIP1-deficient mice results from SHIP deficiency in MSC and osteolineage progenitors. Intriguingly, mice with a SHIP-deficient MSC compartment also exhibit decreased OC numbers. In agreement with our genetic findings we also show that treatment of mice with an SHIP1 inhibitor (SHIPi) significantly reduces bone mass. These findings demonstrate a novel role for SHIP1 in MSC fate determination and bone growth. Further, SHIPi may represent a novel therapeutic approach to limit bone development in osteopetrotic and sclerotic bone diseases.
Progression of Coronary Artery Disease Predicts Clinical Coronary Events (1996)

In this population of nonsmoking men with previous bypass surgery, both the consensus panel- and quantitative coronary angiography-based end points of coronary artery disease progression predict clinical coronary events. Subjects who demonstrate greater coronary artery lesion progression have an increased risk of future clinical coronary events. Design of shorter, smaller trials of antiatherosclerotic agents is justified.
Guided direct antegrade puncture of the superficial femoral artery (1986)

Guided direct antegrade puncture of the superficial femoral arteryHL Berman, SG Katz and DP TihanskyAudio Available | Share
Self-Assembly of DNA Rings from Scaffold-Free DNA Tiles (2013)

We report a scaffold-free approach in which four- and six-helix DNA bundle units, assembled from a small number of single stranded DNA oligonucleotides precisely arranged in networks of contiguous and semicrossover strands, are connected into DNA nano rings. Nearly uniform structures with well-defined diameters of 53 ± 7, 81 ± 9, 85 ± 8, and 166 ± 13 nm were achieved by introducing uniform, in-plane curvature to the repeating units. We demonstrate that precise higher order assemblies can be achieved by fine tuning the particular features of the individual building blocks.
A Comparison of Urologic Application of Bipolar Versus Monopolar Five French Electrosurgical Probes (1989)

Urologic endoscopic procedures often involve electrosurgery. Recently bipolar probes have become commercially available. This study compares monopolar and bipolar electrosurgical probes in relation to power losses in urologic endoscopic instruments with the infusion of sterile water and saline, and the power transmitted by probes to tissue correlated to tissue destruction in each fluid. The power losses through each instrument in both solutions were minimal. The bipolar electrode functioned at a much lower power output than did the monopolar electrode. The bipolar probe was also more effective in saline than sterile water. The depth, width and volume of tissue damage for both electrodes were found to vary with generator power output. The data shows the burns had similar diameters for both probes but the bipolar probe caused significantly less burn depth than the monopolar probe. These initial studies indicate that bipolar electrodes can function in normal saline with less depth damage compared to the monopolar probe.
Passive long range acousto-optic sensor (2006)

Alexander Graham Bell's photophone of 1880 was a simple free space optical communication device that used the sun to illuminate a reflective acoustic diaphragm. A selenium photocell located 213 m (700 ft) away converted the acoustically modulated light beam back into sound. A variation of the photophone is presented here that uses naturally formed free space acousto-optic communications links to provide passive multichannel long range acoustic sensing. This system, called RAS (remote acoustic sensor), functions as a long range microphone with a demonstrated range in excess of 40 km (25 miles).
Fiber coupled waveguide grating structures (2010)

Fabrication and characterization of the miniature device of waveguide grating-structures (WGS) on the end facet of an optical fiber are demonstrated. A layer of ZnO between the fiber and the grating structures serves as the waveguide. The fiber is used to direct the excitation light to the WGS and to carry the signal response back to the detection system. The narrow-band waveguide resonance mode tunable in the visible spectrum can be measured through the fiber in both the transmission and reflection. This nanodevice may be suitable as long-range sensors for the detection of refractive-index changes in nontransparent or toxic liquids.