gebhart/patrepeval huggingface dataset:
Disparities in colorectal cancer screening rates among Asian Americans and non-Latino whites (2005)

Among Asian Americans, colorectal cancer (CRC) is the second most commonly diagnosed cancer, and it is the third highest cause of cancer-related mortality. The 2001 California Health Interview Survey (CHIS 2001) was used to examine 1) CRC screening rates between different Asian-American ethnic groups compared with non-Latino whites and 2) factors related to CRC screening. The CHIS 2001 was a population-based telephone survey that was conducted in California. Responses about CRC screening were analyzed from 1771 Asian Americans age 50 years and older (Chinese, Filipino, South Asian, Japanese, Korean, and Vietnamese). The authors examined two CRC screening outcomes: individuals who ever had CRC screening and individuals who were up to date for CRC screening. For CRC screening, fecal occult blood test (FOBT), sigmoidoscopy/colonoscopy, and any other form of screening were examined. CRC screening of any kind was low in all populations, and Koreans had the lowest rate (49%). Multivariate analysis revealed that, compared with non-Latino whites, Koreans were less likely to undergo FOBT (odds ratio [OR], 0.40; 95% confidence interval [95% CI], 0.25-0.62), and Filipinos were the least likely to undergo sigmoidoscopy/colonoscopy (OR, 0.62; 95% CI, 0.44-0.88) or to be up to date with screening (OR, 0.68; 95% CI, 0.48-0.97). Asian Americans were less likely to undergo screening if they were older, male, less educated, recent immigrants, living with >or= 3 individuals, poor, or uninsured. Asian-American populations, especially Koreans and Filipinos, are under-screened for CRC. Outreach efforts could be more focused on helping Asian Americans to understand the importance of CRC screening, providing accurate information in different Asian languages. Other strategies for increasing CRC screening may include using a more family-centered approach and using qualified translators.
Nucleation with Collapse of Acoustic Cavitation in Molten Al-Si Alloys (2010)

Ultrasonic irradiation during the solidification of molten metals has an effect on grain refinement. However, the mechanism of grain refinement by ultrasonic vibration has not been fully understood yet, so that there exist difficulties to apply the ultrasonic grain refinement to industrial casting processes. In the present study, we propose the mechanism of ultrasonic grain refinement: the nucleation is based on the extremely high pressure generated by the collapse of acoustic cavitation in molten Al-Si alloys. The effect of ultrasonic irradiation into molten Al-Si alloy on the microstructure was firstly studied, that is, molten Al-12.6wt%Si alloy was rapidly cooled down from just above the eutectic temperature after the ultrasonic irradiation. The detailed microstructure observation exhibits that ultrasonic irradiation above the eutectic temperature causes crystalline -Al and silicon to nucleate. Through the measurement of silicon content in -Al nodules solidified with ultrasonic irradiation, the silicon content is higher than that in non-irradiated -Al nodules. It is known that the collapse of acoustic cavitation generates extremely high pressure. At the highly pressurized sites, the eutectic temperature rises and the crystallized -Al nodules contain higher amount of silicon compared with those solidified at ambient pressure. According to the fact that the -Al nodules crystallized above the eutectic temperature contain higher amount of silicon, the irradiated microstructure of -Al nodules is developed at the highly pressurized sites, that is, the collapse of acoustic cavitation induces nucleation and causes grain refinement.
Structual Analysis of Neutral and Acidic Xylooligosaccharides from Hardwood Kraft Pulp, and Their Utilization by Intestinal Bacteriain Vitro (2009)

We established a method for producing two types of xylooligosaccharides by treating kraft pulp derived from hardwood such as eucalyptus with xylanase, analyzed the structure by MALDI-TOF-MS/MS, and conducted an in vitro study on utilization by intestinal bacteria. One type was a neutral xylooligosaccharide (XOS), a xylooligomer in the D.P. range of dimer to approximately 17-mer, containing approximately 12% xylobiose. The other was an acidic xylooligosaccharide (U-XOS), a xylooligomer in the D.P. range of dimer to approximately 17-mer, with a major side chain of 4-O-methyl-glucuronic acid and other side chains of glucuronic acid and 2-O-galactopyranosyl-4-O-methyl-glucurono acid. The in vitro utilization study with intestinal bacteria showed that XOS was specifically utilized by Bifidobacterium, whereas U-XOS was utilized by only a few types of bacteria. In a fecal batch culture, both XOS and U-XOS selectively increased the population of Bifidobacterium. The present study proposes a new method for industrial production of XOS and U-XOS, and indicates the utility and functionality.
Muiltiobjective Optimization Using Nondominated Sorting in Genetic Algorithms (1994)

In trying to solve multiobjective optimization problems, many traditional methods scalarize the objective vector into a single objective. In those cases, the obtained solution is highly sensitive to the weight vector used in the scalarization process and demands that the user have knowledge about the underlying problem. Moreover, in solving multiobjective problems, designers may be interested in a set of Pareto-optimal points, instead of a single point. Since genetic algorithms (GAs) work with a population of points, it seems natural to use GAs in multiobjective optimization problems to capture a number of solutions simultaneously. Although a vector evaluated GA (VEGA) has been implemented by Schaffer and has been tried to solve a number of multiobjective problems, the algorithm seems to have bias toward some regions. In this paper, we investigate Goldberg's notion of nondominated sorting in GAs along with a niche and speciation method to find multiple Pareto-optimal points simultaneously. The proof-of-principle results obtained on three problems used by Schaffer and others suggest that the proposed method can be extended to higher dimensional and more difficult multiobjective problems. A number of suggestions for extension and application of the algorithm are also discussed.
Synaptic vesicle recycling in synapsin I knock-out mice. (1996)

The synapsins are a family of four neuron-specific phosphoproteins that have been implicated in the regulation of neurotransmitter release. Nevertheless, knock-out mice lacking synapsin Ia and Ib, family members that are major substrates for cAMP and Ca2+/ Calmodulin (CaM)-dependent protein kinases, show limited phenotypic changes when analyzed electrophysiologically (Rosahl, T.W., D. Spillane, M. Missler, J. Herz, D.K. Selig, J.R. Wolff, R.E. Hammer, R.C. Malenka, and T.C. Sudhof. 1995. Nature (Lond.). 375: 488-493; Rosahl, T.W., M. Geppert, D. Spillane, D., J. Herz, R.E. Hammer, R.C. Malenka, and T.C. Sudhof. 1993. Cell. 75:661-670; Li, L., L.S. Chin, O. Shupliakov, L. Brodin, T.S. Sihra, O. Hvalby, V. Jensen, D. Zheng, J.O. McNamara, P. Greengard, and P. Andersen. 1995. Proc. Natl. Acad. Sci. USA. 92:9235-9239; see also Pieribone, V.A., O. Shupliakov, L. Brodin, S. Hilfiker-Rothenfluh, A.J. Czernik, and P. Greengard. 1995. Nature (Lond.). 375:493-497). Here, using the optical tracer FM 1-43, we characterize the details of synaptic vesicle recycling at individual synaptic boutons in hippocampal cell cultures derived from mice lacking synapsin I or wild-type equivalents. These studies show that both the number of vesicles exocytosed during brief action potential trains and the total recycling vesicle pool are significantly reduced in the synapsin I-deficient mice, while the kinetics of endocytosis and synaptic vesicle repriming appear normal.
Planar integration of E/D-mode AlGaN/GaN HEMTs using fluoride-based plasma treatment (2006)

A planar-fabrication technology for integrating enhancement/depletion (E/D)-mode AlGaN/GaN high-electron mobility transistors (HEMTs) has been developed. The technology relies heavily on CF/sub 4/ plasma treatment, which is used in two separate steps to achieve two objectives: 1) active device isolation and 2) threshold-voltage control for the enhancement-mode HEMT formation. Using the planar process, depletion- and enhancement-mode AlGaN/GaN HEMTs are integrated on the same chip, and a direct-coupled FET logic inverter is demonstrated. Compared with the devices fabricated by a standard mesa-etching technique, the HEMTs by a planar process have comparable dc and RF characteristics with no obvious difference in the device isolation. The device isolation by a plasma treatment remains the same after 400 /spl deg/C annealing, indicating a good thermal stability. At a supply voltage (V/sub DD/) of 3.3 V, the E/D-mode inverters show an output swing of 2.85 V, with the logic-low and logic-high noise margins at 0.34 and 1.47 V, respectively.
Long-Term Safety and Tolerability of Valbenazine (NBI-98854) in Subjects with Tardive Dyskinesia and a Diagnosis of Schizophrenia or Mood Disorder (2025)

Valbenazine appeared to be well tolerated in adults with TD who received up to 48 weeks of treatment. In addition to long-term efficacy results (presented separately), these results suggest that valbenazine may be appropriate for the long-term management of TD regardless of underlying psychiatric diagnosis (SCHZ disorder or mood disorder).
F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study (1993)

Abstract Studies on baboons and preliminary observations in three patients with sickle cell anemia (SS) suggested that high doses of pulse administered recombinant human erythropoietin (rHuEPO) stimulate F-reticulocyte production. We now report on the administration of rHuEPO in a double- blind format to ascertain frequency of response and potential precipitation of side effects. Ten patients were enrolled, but one was discontinued due to the indication of a blood transfusion. Of the other nine, five received rHuEPO in escalating doses (from 400 to 1,500 U per kg twice daily [BID] per week), alternating with a placebo, in blinded fashion. The second group, consisting of four patients, followed an identical protocol (except starting dose was 1,000 U/Kg, BID per week) and were iron supplemented during treatment. The criterion of response was a transient doubling (as a minimum) of the steady-state F- reticulocyte level. We found that none of the five patients in the first group responded to rHuEPO, and two of them became iron deficient, as judged by a significant decrease in ferritin. Of the second group, four patients responded with F-reticulocyte increases. In three patients, open label administration of rHuEPO confirmed the effect. We observed seven painful episodes during this study, two during the EPO administration and five during the placebo arm. Three patients were phlebotomized because the hemoglobin level increased 1.5 g/dL more than steady-state levels. Of the six patients followed-up by percent dense cell determinations, one exhibited increased levels during periods of the treatment, whereas the other five showed no change. No anti-rHuEPO antibodies were detected. We conclude that rHuEPO can stimulate F- reticulocyte response in some patients with sickle cell anemia, without apparent negative clinical side effects. The state of iron stores may be critical. Whether higher doses of rHuEPO and/or a different regimen might induce sustained F cells and fetal hemoglobin increases remains to be determined.
Three-dimensional Model of the Pore Form of Anthrax Protective Antigen. Structure and Biological Implications (2004)

Although pore formation by protective antigen (PA) is critical to cell intoxication by anthrax toxin (AT), the structure of the pore form of PA (the PA63 pore) has not been determined. Hence, in this study, the PA63 pore was modeled using the X-ray structures of monomeric PA and heptameric alpha-hemolysin (alpha-HL) as templates. The PA63 pore model consists of two weakly associated domains, namely the cap and stem domains. The ring-like cap domain has a length of 80 A and an outside diameter of 120 A, while the cylinder-like stem domain has a length of 100 A and outside diameter of approximately 28 A. This provides the PA63 pore model with a length of 180 A. Based on experimental results, the channel in the PA63 pore model was built to have a minimum diameter of ~12 A, depending on side chain conformations. Because of its large size and structural complexity, the all-atom model of the PA63 pore is the end-stage construction of four separate modeling projects described herein. The final model is consistent with published experimental results, including mutational analysis and channel conductance experiments. In addition, the model was energetically and hydropathically refined to optimize molecular packing within the protomers and at the protomer-protomer interfaces. By providing atomic detail to biochemical and biophysical data, the PA63 pore model may afford new insights into the binding mode of PA on the membrane surface, the prepore-pore transition, and the mechanism of cell entry by anthrax toxin.
2009 ISSLS Prize Winner: Does Discography Cause Accelerated Progression of Degeneration Changes in the Lumbar Disc (2009)

Modern discography techniques using small gauge needle and limited pressurization resulted in accelerated disc degeneration, disc herniation, loss of disc height and signal and the development of reactive endplate changes compared to match-controls. Careful consideration of risk and benefit should be used in recommending procedures involving disc injection.
Das erste Titanat mit „Stuffed Pyrgoms”: RbNa3Li12[TiO4]4 = RbNa3Li8{Li[TiO4]}4 (1994)

Abstract Durch Tempern eines innigen Gemenges der binären Oxide Rb 2 O, Na 2 O, Li 2 O und TiO 2 [Rb:Na:Li:Ti = 1,1:3,1:12,5:4,0; 780°C, 41 d] wurde RbNa 3 Li 8 {Li[TiO 4 ]} 4 in Form von farblosen Plättchen erhalten. Das erste Titanat mit „stuffed pyrgoms”︁ ist isotyp zu RbNa 3 Li 8 {Li[SiO 4 ]} 4 , CsKNa 2 Li 8 {Li[SiO 4 ]} 4 und CsKNaLi 9 {Li[SiO 4 ]} 4 [2]. Die Verbindung kristallisiert tetragonal I 4/ m mit den Gitterkonstanten a = 1 125,8(1) pm und c = 652,4(1) pm (Guinier‐Simon‐Daten, Z = 2). Die Struktur wurde mit Vierkreisdiffraktometerdaten (Siemens AED2, 657I o ( hkl ), MoK ) aufgeklärt und führte zu den Residualwerten R = 3,7% und R w = 3,1% (weitere Daten siehe Text). Der Madelunganteil der Gitterenergie (MAPLE), Effektive Koordinationszahlen (ECoN), Mittlere Fiktive Ionenradien (MEFIR) sowie die Ladungsverteilung (CHARDI) werden berechnet und diskutiert.
Novel Function of Human RLIP76:  ATP-Dependent Transport of Glutathione Conjugates and Doxorubicin (2000)

Active transport of conjugated and unconjugated electrophiles out of cells is essential for cellular homeostasis. We have previously identified in human tissues a transporter, DNP-SG [S-(2,4-dinitrophenyl)glutathione] ATPase, capable of carrying out this function [Awasthi et al. (1998) Biochemistry 37, 5231−5238, 5239−5248]. We now report the cloning of DNP-SG ATPase. The sequence of the cDNA clone was identical to that of human RLIP76, a known Ral-binding protein. RLIP76 expressed in E. coli was purified by DNP-SG affinity chromatography. Purified recombinant RLIP76: (1) had ATPase activity stimulated by DNP-SG or doxorubicin (DOX), and the Km values of RLIP76 for ATP, DOX, and DNP-SG were similar to those reported for DNP-SG ATPase; (2) upon reconstitution with asolectin as well as with defined lipids, catalyzed ATP-dependent transport of DNP-SG and DOX with kinetic parameters similar to those of DNP-SG ATPase; (3) when transfected into K562 cells, resulted in increased resistance to DOX, and increased ATP-dependent transport of DNP-SG and DOX by inside-out membrane vesicles from transfected cells; (4) direct uptake of purified RLIP76 protein into mammalian cells from donor proteoliposomes confers DOX resistance. These results indicate that RLIP76, in addition to its role in signal transduction, can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
A Study on the Development of Chemical Vapor Deposition Precursors. 4. Syntheses and Characterization of New N-Alkoxo-β-ketoiminate Complexes of Niobium and Tantalum (2002)

Partial replacement of ethoxide ligands with N-alkoxo-β-ketoiminates in the tantalum or niobium ethoxides resulted in M(N-alkoxo-β-ketoiminate)(OEt)3 (M = Ta and Nb) complexes. Most of these complexes are liquid and showed enhanced thermal and chemical stability, especially toward moisture. These complexes have octahedral geometry with a meridional N-alkoxo-β-ketoiminate ligand and showed fluxional behaviors. All of these precursors, especially the ones with methyl groups on both the N-alkoxo and β-ketoiminate backbones, demonstrate considerably higher deposition rates than M2(OEt)10 (M = Ta and Nb), one of the most popular precursors for Ta2O5 and Nb2O5 films. Thermogravimetric analysis experiments showed that successive decomposition of ethoxide ligands is followed by decomposition of N-alkoxo-β-ketiminate in the pyrolysis process. Introduction of a methyl group onto the N-hydroxyethyl backbone enhanced the thermal stability at lower temperatures and the pyrolysis rate at higher temperatures. X-ray diffraction patterns indicate that the deposited films are not crystallized until the substrate temperature goes over 650 °C. Well-crystallized longish grains were formed in the Ta2O5 film deposited at 700 °C, but it was found from the depth profile spectra by Auger electron spectroscopy (AES) that the nitrogen and carbon impurities are 2.3% and 4.2%, respectively, for the Ta2O5 film deposited at 550 °C. Heat treatment at 700 °C in oxygen removed the nitrogen impurity in this Ta2O5 completely, and the residual carbon was proved to be negligible from the AES and X-ray photoelectron spectroscopy results.
Decentralized Multi-Agent System-Based Cooperative Frequency Control for Autonomous Microgrids With Communication Constraints (2014)

Based on power line carrier communication technology, a decentralized multi-agent system (DMAS)-based frequency control strategy is proposed and investigated in this study on an autonomous microgrid with communication constraints, where each agent can only communicate with its neighboring agents. Using the optimized average consensus algorithm, the global information (i.e., total active power deficiency of the microgrid) can be accurately shared in a decentralized way. Depending on the discovered global information, the cooperative frequency control strategy, which involves primary and secondary frequency control and multi-stage load shedding, is executed to achieve a cooperative frequency recovery. Simulation results indicate that the proposed frequency control approach can guarantee the consensus and coordination of the distributed agents and maintain the frequency stability of islanded microgrids even in emergency conditions.
INDUCTION OF TRANSPLANTATION TOLERANCE IN ADULT ANIMALS (1965)

Journal Article INDUCTION OF TRANSPLANTATION TOLERANCE IN ADULT ANIMALS Get access G. GOWLAND, Ph.D. G. GOWLAND, Ph.D. Division of Erperimental Biology National Institute for Medical ResearchLondon Search for other works by this author on: Oxford Academic PubMed Google Scholar British Medical Bulletin, Volume 21, Issue 2, May 1965, Pages 123–128, https://doi.org/10.1093/oxfordjournals.bmb.a070379 Published: 01 May 1965
Diffusion and regionalization in membranes of maturing ram spermatozoa. (1984)

An essential feature of the "fluid mosaic model" (Singer, S. J., and G. L. Nicolson , 1972, Science (Wash. DC)., 175:720-731) of the cell plasma membrane is the ability of membrane lipids and proteins to diffuse laterally in the plane of the membrane. Mammalian sperm are capable of overcoming free random diffusion and restricting specific membrane components, both lipid and protein, to defined regions of the sperm's surface. The patterns of these regionalizations evolve with the processes of sperm differentiation: spermatogenesis, epididymal maturation, and capacitation. We have used the technique of fluorescence recovery after photobleaching to measure the diffusion of the lipid analogue 1,1'- dihexadecyl 3,3,3',3'- tetramethylindocarbocyanine perchlorate ( C16dil ) on the different morphological regions of testicular and ejaculated ram spermatozoa. We have found: (a) that the major morphologically distinct regions (head, midpiece, and tail) of the plasma membrane of both testicular and ejaculated spermatozoa are also physically distinct as measured by C16dil diffusibility; (b) that despite regional differences in diffusibility there is exchange of this lipid analogue by lateral diffusion between the major morphological regions of the plasma membrane; and (c) that epididymal maturation results in changes in C16dil diffusibility in the different regions of the sperm plasma membrane. In particular, the plasma membranes of the anterior and posterior heads become physically distinct.
Hormones, vitamins, and growth factors in cancer treatment and prevention. A critical appraisal. (1996)

It is hoped that the data presented in this review regarding the role of hormones, hormone agonists, hormone antagonists, vitamins, growth factors, and growth factor inhibitors will provide a rationale for designing effective new cancer chemoprevention strategies and clinical trials.
TVQA: Localized, Compositional Video Question Answering (2018)

Recent years have witnessed an increasing interest in image-based question-answering (QA) tasks. However, due to data limitations, there has been much less work on video-based QA. In this paper, we present TVQA, a large-scale video QA dataset based on 6 popular TV shows. TVQA consists of 152,545 QA pairs from 21,793 clips, spanning over 460 hours of video. Questions are designed to be compositional in nature, requiring systems to jointly localize relevant moments within a clip, comprehend subtitle-based dialogue, and recognize relevant visual concepts. We provide analyses of this new dataset as well as several baselines and a multi-stream end-to-end trainable neural network framework for the TVQA task. The dataset is publicly available at http://tvqa.cs.unc.edu.
Three genes for lupus nephritis in NZB x NZW mice. (1978)

The occurrence of early severe lupus nephritis in (NZB x NZW)F1 mice must depend on the action of at least two dominant or codominant genes (at least one gene from each parent) as neither of the inbred parental strains shows the disorder. Identifying affected animals by antemortem determinations of renal function, we have studied the incidence of the renal disease in 230 (NZB x NZW) x NZW backcross mice (an earlier study) and, in this study, in 150 (NZB x NZW) x NZB backcross mice. The data indicate that the NZB strain contributes only one gene and the NZW strain contributes two genes, or clusters of closely linked genes, to the renal disorder of the F1 hybrid. One of the NZW genes was found to be linked to the H-2 complex. All three genes must be dominant or codominant, as their effect is expressed in the heterozygous state.
Dielectrically defined optical T-gate for high power GaAs pHEMTs (2002)

A dielectrically defined gate process has been developed that uses optical lithography to pattern near quarter micron T-gates. Record output power densities of 2.0 and 1.8 W/mm have been measured at 2 and 10 GHz, respectively. When applied to an X-band MMIC circuit, significantly higher power was measured. The new process offers improved performance and throughput compared to the standard e-beam defined T-gates. Initial results indicate that yield is better as well. These improvements are attributed to passivating the GaAs surface at an earlier step, resulting in fewer surface states and traps.