gebhart/patrepeval huggingface dataset:
<title>Photobook: tools for content-based manipulation of image databases</title> (1994)

We describe the Photobook system, which is a set of interactive tools for browsing and searching images and image sequences. These tools differ from those used in standard image databases in that they make direct use of the image content rather than relying on annotations. Direct search on image content is made possible by use of semantics-preserving image compression, which reduces images to a small set of perceptually-significant coefficients. We describe three Photobook tools in particular: one that allows search based on grey-level appearance, one that uses 2D shape, and a third that allows search based on textural properties.
Expression and localization of placenta growth factor and PlGF receptors in human meningiomas (1999)

It has previously been suggested that in human brain tumours, endothelial cell proliferation during angiogenesis is regulated by a paracrine mechanism involving vascular endothelial growth factor (VEGF) and its receptors (VEGF receptor 1 and VEGF receptor 2). The mechanism of growth factor up-regulation is based on hypoxic activation of mRNA expression and mRNA stabilization and genetic events, leading to an increase of growth factor gene expression. The role of the other newly discovered VEGF family members with a high specificity for endothelial cells in the pathogenesis of glial neoplasms is unknown. To investigate which other members of the VEGF family are overexpressed in human brain tumours, the mRNA levels of placenta growth factor (PlGF), VEGF-A, and VEGF-B genes were determined by northern blot analysis in surgically obtained human meningiomas. In the 16 meningiomas examined, the mRNA for PlGF was highly expressed in four tumours and VEGF-A mRNA was highly abundant in three tumour samples. There was no close correlation between PlGF mRNA levels and VEGF-A expression levels. VEGF-B mRNA was abundantly expressed in all tumour samples at uniform levels. In a PlGF-positive tumour sample, immunoreactive VEGFR-1 and VEGFR-2 were detected in endothelial cells of the blood vessels. PlGF protein was detectable in most but not all capillaries of the tumour. PlGF is thus highly up-regulated in a subset of human meningiomas and may therefore have functions, in some tumour vessels, connected to endothelial cell maturation and tube formation. These findings suggest that PlGF, in addition to VEGF-A, may be another positive factor in tumour angiogenesis in human meningiomas.
Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil (1991)

To test whether primitive hematopoietic stem cells (PHSC) cycle rapidly during recovery from an initial 5-fluorouracil (5-FU) treatment, two doses of 5-FU were administered 1, 3, 5 or 8 days apart. Cells from treated marrow donors were mixed with untreated competitor marrow that would produce genetically distinguishable erythrocytes and lymphocytes, using hemoglobin (Hb) and glucosephosphate isomerase (GPI) transplantation markers. These cell mixtures were injected into lethally irradiated hosts. Functional abilities of donor marrow populations were assessed after 3, 6, and 12 months as percentages of donor type Hb and GPI in the host's circulating erythrocytes and lymphocytes, respectively. Bone marrow from mice treated with two doses of 5-FU 3 to 5 days apart was severely affected, producing circulating erythroid and lymphoid cells an average of only 25% of normal for doses 3 days apart, and 14% of normal for doses 5 days apart. Two doses of 5-FU administered 1 day or 8 days apart had much smaller effects, producing circulating cells 75% or 58% of normal. Thus, most PHSC are stimulated to proliferate rapidly 3 to 5 days after treatment with 5-FU, but far fewer PHSC proliferate as early as 1 day, or as late as 8 days, after the 5-FU treatment.
Changes in circulating microRNA levels associated with prostate cancer (2012)

These observations suggest that changes in miR concentration in prostate cancer patients may be identified by analysing various body fluids. Moreover, circulating miRs may be used to diagnose and stage prostate cancer.
Surface Sampling by Spray-Desorption Followed by Collection for Chemical Analysis (2010)

Desorption electrospray ionization (DESI) directly analyzes soluble chemical components present on surfaces when a pneumatically assisted electrospray is directed at the sample. Here we demonstrate that the same spray desorption mechanism that operates in DESI can be used as a general technique to collect soluble materials present on surfaces. After desorption analytes are collected on a suitable collection surface, large areas can be scanned and collected onto a small collected area, which allows for preconcentration of low abundance material before analysis. This collection surface can then subsequently be analyzed by DESI but also by many other techniques such as gas chromatography-mass spectrometry or UV-vis spectroscopy. In addition this technique can be used to study desorption mechanisms in DESI independently from ionization mechanisms. Preliminary results indicate that the optimized conditions in DESI are a compromise between those conditions that are optimum for desorption and conditions that lead to efficient ionization.
The Nasal Valve: A Rhinomanometric Evaluation of Maximum Nasal Inspiratory Flow and Pressure Curves (1986)

The nasal valve is defined as the region of the nasal airway bounded by the caudal end of the upper lateral cartilages and the nasal septum. During inspiration this region of the nasal airway may collapse and produce a marked increase in nasal airway resistance. To define the function of this region, measurements of the nasal airway resistance in 38 subjects were performed. Using anterior mask rhinomanometry, right and left total nasal resistance, right and left upstream nasal resistance, right and left downstream nasal resistance, and right and left transmural collapsing pressure of the nasal valve were measured. Subjects who complained of nasal obstruction and had anatomical evidence of anterior nasal deformity showed a reduced level of transmural closing pressure compared with subjects complaining of no airway obstruction or those with anatomical evidence of posterior nasal deformity. This suggests that premature collapse of the nasal valve due to inadequate cartilaginous support is an important factor in producing nasal airway obstruction in individuals with anterior nasal septal abnormality. In those individuals with nasal airway obstruction and anatomical evidence of posterior nasal deformity, downstream nasal resistance was elevated compared with the asymptomatic group and the group with anatomical evidence of anterior nasal septal deformity. This paper demonstrates that premature collapse of the nasal valve is responsible for the symptom of nasal obstruction in many patients with anterior nasal septal deformity.
Gravimetric analysis of uniform polyhedra (1996)

Abstract Analytical formulas for the gravity anomaly of a uniform polyhedral body are subject to numerical error that increases with distance from the target, while the anomaly decreases. This leads to a limited range of target distances in which the formulas are operational, beyond which the calculations are dominated by rounding error. We analyze the sources of error and propose a combination of numerical and analytical procedures that exhibit advantages over existing methods, namely (1) errors that diminish with distance, (2) enhanced operating range, and (3) algorithmic simplicity. The latter is achieved by avoiding the need to transform coordinates and the need to discriminate between projected observation points that lie inside, on, or outside a target facet boundary. Our error analysis is verified in computations based on a published code and on a code implementing our methods. The former requires a numerical precision of one part in 1016 (double precision) in problems of geophysical interest, whereas our code requires a precision of one part in 107 (single precision) to give comparable results, typically in half the execution time.
Incoherent optical image processing with acousto-optic pupil-plane filtering (1995)

We describe an incoherent image processor that uses orthogonally oriented one-dimensional acousto-optic cells to implement dynamic, arbitrary bipolar point-spread functions (PSF’s). Arbitrary PSF’s are implemented as a linear superposition in time of separable PSF’s. The use of incoherent illumination increases the input field of view over that provided by coherent illumination, and implementation of the PSF by a pupil-plane filter yields a simple, compact single-lens imaging system. The acousto-optic cells offer a faster PSF update rate than that of conventional spatial light modulators, which is a critical issue for the implementation of a bipolar PSF as a subtraction between its positive and rectified negative parts. Initial experimental results are presented that demonstrate the realization of an arbitrary nonseparable PSF, image convolution with a bipolar PSF, two-dimensional image correlation, and an increased processor field of view.
Doping of ZnO by group-IB elements (2006)

The authors present their first-principles calculations of doping effects in ZnO with group-IB elements such as Cu, Ag, and Au. The calculated transition energies ε(0∕−) for substitutional Cu, Ag, and Au are 0.7, 0.4, and 0.5eV, respectively. The calculated formation energies are very low for these group-IB elements on the substitutional sites, but rather high at the interstitial sites under oxygen-rich growth conditions. Under the conditions, the formation of major hole-killer defects, such as oxygen vacancies and Zn interstitial, are suppressed. Thus, Ag may be a good candidate for producing p-type ZnO.
MEASUREMENT OF HEAD IMPACTS IN COLLEGIATE FOOTBALL PLAYERS (2007)

Our findings suggest that sustaining an impact greater than 90 g does not result in acute observable balance and neurocognitive deficits within 24 hours of sustaining the impact. Although previous studies have suggested a theoretical injury threshold, none have been founded on empirical data collected on the playing field in real-time. Future studies should consider the cumulative effects of impacts of varying magnitudes.
Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures. (1990)

To study the regulation of insulin gene expression by physiological regulators, primary cultures of rat islet cells were transfected with portions of the rat insulin I gene 5'-flanking sequence linked to the reporter gene chloramphenicol acetyltransferase (CAT). Incubation of the cells in increasing glucose concentrations led to a parallel increase in both CAT activity and CAT mRNA levels. Pretreatment of the cells with the beta-cell-specific toxin streptozotocin reduced CAT activity 97%. Beta-Cell-specific expression of CAT was also demonstrated by co-staining the transfected cells with antisera to both CAT and insulin. Experiments showing a reduction in the response to glucose in the presence of the calcium channel blocker verapamil suggest that calcium plays a role in the glucose response, possibly via regulation of factors interacting with this limited portion of the insulin gene.
Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. (1986)

Monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of platelet-activating factor (PAF) in cultured human vascular endothelial cells (HEC). The product was identified as PAF by its behavior in chromatographic systems, its recovery of biological activity, and its physico-chemical properties and susceptibility to lipases. The response of HEC to IL-1 was concentration-dependent, took more than 2 h to become apparent, and decreased after 18 h of incubation. Most of the PAF produced was cell-associated and only a small amount (about 25% of the total) was released in the culture medium. To study the mechanism of IL-1-induced HEC-PAF production we tested the activity of 1-O-alkyl-sn-glycero-3-phosphocholine:acetyl/coenzyme A acetyltransferase in HEC. Acetyltransferase activity measured in IL-1-stimulated HEC lysates showed a three to five times greater maximum velocity, but the same Michaelis constant, as untreated cells. The regulation of PAF generation in HEC by IL-1 may be an important aspect of the two-way interaction between immunocompetent cells and vascular tissue.
Investigation of the Asphaltene Precipitation Process from Cold Lake Bitumen by Confocal Scanning Laser Microscopy (1995)

Abstract The equilibrium asphaltene particle shape, size and size distribution were investigated by Confocal Scanning Microscopy (CSLM). Using CSLM, better quality images of asphaltene particles were obtained. The 3-D reconstruction from 2-D images capability of CSLM was used to visulaize the shape of the asphaltene particles. They were found to be highly non-spherical. With the CSLM operating in the fluorescence mode using incident light of 586 nm, it was found that freshly precipitated asphaltene particles gave strong fluorescence. However, if the sample was exposed to air, the fluorescence intensity quenches over a period of 24–48 hours indicating chemical changes, possibly oxidation, was taking place. Contrast to this, in a dry nitrogen atmosphere, the asphaltene particles maintained their fluorescence over the entire period when the experiment was carried out. Fluorescence emission by asphaltene particles provides yet another alternative for its size and size distribution determination especially for samples with a dark background. Imaging of such system would be less dependent on the incident light intensity. Asphaltene samples prepared at the industrially more relevant low bitumen to solvent ratios are being investigated by this method.
Nonalcoholic Fatty Liver Disease (2002)

Alcohol abuse is the most common cause of fatty liver disease, but it is now apparent that fat deposition in the liver, and its consequences, may occur without alcohol abuse. The principal risk factors are obesity, non-insulin-dependent diabetes mellitus, and hyperlipidemia. The disorder has a wide clinical spectrum, ranging from asymptomatic steatosis to steatohepatitis, fibrosis, and cirrhosis. This article provides a broad overview of this increasingly recognized liver disease.
Cr3+substituted spinel ferrite nanoparticles with high coercivity (2016)

The low coercivity of spinel ferrites is a major barrier that significantly limits their use in high density magnetic recording applications. By controlling the substituting content of Cr(3+), in this article we describe how magnetic CoCr x Fe2-x O4 (0 < x < 1.2) nanoparticles with coercivity of up to 6.4 kOe were successfully obtained by the hydrothermal process. The high coercivity is attributed to the synergetic effects of magnetocrystalline anisotropy and the nanoscale size effect. X-ray diffraction analysis confirmed the spinel structure of the nanoparticles with transmission electron microscopy (TEM) suggesting regular tetragonal morphology. The TEM indicated an edge length ranging from 15 nm to 150 nm, which increases monotonically with increasing Cr content. Raman analyses supported the proposed model on the formation mechanism of the nanoparticles, i.e. heterogeneous and homogeneous nucleation.
Disabling ErbB Receptors with Rationally Designed Exocyclic Mimetics of Antibodies:  Structure−Function Analysis (2001)

Overexpression of the HER2 receptor is observed in about 30% of breast and ovarian cancers and is often associated with an unfavorable prognosis. We have recently designed an anti-HER2 peptide (AHNP) based on the structure of the CDR-H3 loop of the anti-HER2 rhumAb 4D5 and showed that this peptide can mimic some functions of rhumAb 4D5. The peptide disabled HER2 tyrosine kinases in vitro and in vivo similar to the monoclonal antibody (Park, B.-W. et al. Nat. Biotechnol. 2000, 18, 194--198). AHNP has been shown to selectively bind to the extracellular domain of the HER2 receptor with a submicromolar affinity in Biacore assays. In the present paper, we demonstrate that in addition to being a structural and functional mimic of rhumAb 4D5, AHNP can also effectively compete with the antibody for binding to the HER2 receptor indicating a similar binding site for the peptide and the parental antibody. To further develop AHNP as an antitumor agent useful for preclinical trials and as a radiopharmaceutical to be used for tumor imaging, a number of derivatives of AHNP have been designed. Structure--function relationships have been studied using surface plasmon resonance technology. Some of the AHNP analogues have improved binding properties, solubility, and cytotoxic activity relative to AHNP. Residues in the exocyclic region of AHNP appear to be essential for high-affinity binding. Kinetic and equilibrium analysis of peptide-receptor binding for various AHNP analogues revealed a strong correlation between peptide binding characteristics and their biological activity. For AHNP analogues, dissociation rate constants have been shown to be better indicators of peptide biological activity than receptor-binding affinities. This study demonstrates a possibility of mimicking the well-documented antibody effects and its applications in tumor therapy by much smaller antibody-based cyclic peptides with potentially significant therapeutic advantages. Strategies used to improve binding properties of rationally designed AHNP analogues are discussed.
Struck: Structured output tracking with kernels (2011)

Adaptive tracking-by-detection methods are widely used in computer vision for tracking arbitrary objects. Current approaches treat the tracking problem as a classification task and use online learning techniques to update the object model. However, for these updates to happen one needs to convert the estimated object position into a set of labelled training examples, and it is not clear how best to perform this intermediate step. Furthermore, the objective for the classifier (label prediction) is not explicitly coupled to the objective for the tracker (accurate estimation of object position). In this paper, we present a framework for adaptive visual object tracking based on structured output prediction. By explicitly allowing the output space to express the needs of the tracker, we are able to avoid the need for an intermediate classification step. Our method uses a kernelized structured output support vector machine (SVM), which is learned online to provide adaptive tracking. To allow for real-time application, we introduce a budgeting mechanism which prevents the unbounded growth in the number of support vectors which would otherwise occur during tracking. Experimentally, we show that our algorithm is able to outperform state-of-the-art trackers on various benchmark videos. Additionally, we show that we can easily incorporate additional features and kernels into our framework, which results in increased performance.
Detection of HIV-1 DNA and Messenger RNA in Individual Cells by PCR-Driven in Situ Hybridization and Flow Cytometry (1993)

Human immunodeficiency virus type-1 (HIV-1) DNA and messenger RNA sequences in both cell lines and blood obtained directly from HIV-1-infected patients were amplified by polymerase chain reaction and hybridized to fluorescein-labeled probes in situ, and the individually labeled cells were analyzed by flow cytometry. After flow cytometric analysis, heterogeneous cell populations were reproducibly resolved into HIV-1-positive and -negative distributions. Fluorescence microscopy showed that the cellular morphology was preserved and intracellular localization of amplified product DNA was maintained. Retention of nonspecific probe was not observed. Analysis of proviral DNA and viral messenger RNA in cells in the blood of HIV-1-infected patients showed that the HIV-1 genome persists in a large reservoir of latently infected cells. With the use of this technique it is now possible to detect single-copy DNA or low-abundance messenger RNA rapidly and reproducibly in a minor subpopulation of cells in suspension at single-cell resolution and to sort those cells for further characterization.
Characterization of clonogenic multiple myeloma cells (2003)

The identity of the cells responsible for the initiation and maintenance of multiple myeloma (MM) remains unclear largely because of the difficulty growing MM cells in vitro and in vivo. MM cell lines and clinical specimens are characterized by malignant plasma cells that express the cell surface antigen syndecan-1 (CD138); however, CD138 expression is limited to terminally differentiated plasma cells during B-cell development. Moreover, circulating B cells that are clonally related to MM plasma cells have been reported in some patients with MM. We found that human MM cell lines contained small (< 5%) subpopulations that lacked CD138 expression and had greater clonogenic potential in vitro than corresponding CD138+ plasma cells. CD138- cells from clinical MM samples were similarly clonogenic both in vitro and in nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice, whereas CD138+ cells were not. Furthermore, CD138- cells from both cell lines and clinical samples phenotypically resembled postgerminal center B cells, and their clonogenic growth was inhibited by the anti-CD20 monoclonal antibody rituximab. These data suggest that MM "stem cells" are CD138- B cells with the ability to replicate and subsequently differentiate into malignant CD138+ plasma cells.
Robustness of the Learning with Errors Assumption (2010)

Abstract: Starting with the work of Ishai-Sahai-Wagner and Micali-Reyzin, a new goal has been set within the theory of cryptography community, to design cryptographic primitives that are secure against large classes of side-channel attacks. Recently, many works have focused on designing various cryptographic primitives that are robust (retain security) even when the secret key is “leaky”, under various intractability assumptions. In this work we propose to take a step back and ask a more basic question: which of our cryptographic assumptions (rather than cryptographic schemes) are robust in presence of leakage of their underlying secrets? Our main result is that the hardness of the learning with error (LWE) problem implies its hardness with leaky secrets. More generally, we show that the standard LWE assumption implies that LWE is secure even if the secret is taken from an arbitrary distribution with sufficient entropy, and even in the presence of hard-to-invert auxiliary inputs. We exhibit various applications of this result. 1. Under the standard LWE assumption, we construct a symmetric-key encryption scheme that is robust to secret key leakage, and more generally maintains security even if the secret key is taken from an arbitrary distribution with sufficient entropy (and even in the presence of hard-to-invert auxiliary inputs).