gebhart/patrepeval huggingface dataset:
The C-shunt Flux Qubit: A New Generation of Superconducting Flux Qubit (2014)

While quantum computation has the potential to revolutionize the scientific community, to date no architecture has been developed which offers the necessary combination of high coherence times and massive scalability. Superconducting flux qubits satisfy the second requirement well but to date useful devices are limited to coherence times of typically only a few &amp;amp;mus. In this dissertation we examine the possibilities of improving the coherence performance of the flux qubit to the levels required for fault-tolerant quantum computation. We find that coherence times for many devices are limited by photon-induced quasiparticles and mitigation of these quasiparticles increases coherence times by more than a factor of two. Beyond this, however, we find little improvement in flux qubit performance compared to prior results. Despite improved fabrication techniques and varied device designs we find flux qubit coherence times are still typically below 5 &amp;amp;mus. Furthermore, wide device-to-device variations are observed which prevent effective scaling of the flux qubit to quantum information circuits.Based on the proposal by You, et al. we develop of a capacitively-shunted version of the flux qubit called the C-shunt flux qubit. With the addition of a capacitive shunt across the small junction of the flux qubit we are able to reduce the amplitude sensitivity to both charge and flux noise by more than a factor of three. The result is a predicted ten-fold enhancement in the coherence times compared to the unshunted flux qubit. At the same time we preserve much of the anharmonicity of the flux qubit resulting in a device with coherence times comparable to modern transmons but with a factor of four better anharmonicity and more flexible coupling configurations.By using a high-quality MBE aluminum shunt process on an annealed sapphire substrate coupled with a more conventional electron-beam-evaporated aluminum Josephson junction process we fabricate hybrid C-shunt flux qubits. We also incorporate a new bridgeless junction technique which offers more robust and repeatable fabrication processing. This technique enables improved accuracy of the junction sizing, a trait which will become essential as we move to multi-qubit experiments. T1 and T2 times for these C-shunt devices reach in excess of 40 &amp;amp;mus at degeneracy, achieving the predicted ten-fold improvement based on the reduced noise sensitivity. At the same time we see decreased device-to-device variation with typical T1 times exceeding 20&amp;amp;ndash25 &amp;amp;mus at all bias points. Combined with the high anharmonicity and standard planar fabrication techniques these coherence times make the C-shunt flux qubit a competitive candidate for fault-tolerant quantum computation.
Prins‐Type Cyclization Reactions in Natural Product Synthesis (2013)

Abstract Prins‐type cyclization reactions proceed through the intramolecular addition of a π‐nucleophile to an oxocarbenium ion or related species to generate a ring through carbon–carbon bond formation, often with excellent and predictable stereocontrol. The widespread presence of naturally occurring oxygen‐containing heterocycles has made these reactions exceedingly valuable for total synthesis efforts. This microreview covers several common variations of Prins‐type cyclizations and highlights their applicability to the total synthesis of natural products and analogs.
An early semiotic (2014)

The origin of a system of thought today referred to as Semiotic(s) is typically traced to sixth century BCE Greek philosophy and medicine. It is argued here, however, that semiotics should not be seen as the exclusive product of western thought and that a parallel semiotics – a systematic exploration and organization of signs in a world constructed of signs – developed in early Chinese philosophy and medicine at approximately the same time or earlier. Both ancient traditions were scientific (though not in today's terms), rational, comprehensive, and based on a natural philosophy that saw the body and its functioning in entirely natural terms.
Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420 (2007)

The plasma pharmacokinetics of erlotinib in this child overlapped with results described in adults. Oral administration of erlotinib achieves CSF concentrations comparable with those active against several cancer cell lines in preclinical models.
Insights Into the Role of Deiodinases from Studies of Genetically Modified Animals (2005)

The deiodinases function at a pre-receptor level in tissues to modulate the concentrations, and thus the actions, of thyroid hormones. Although much has been learned in the last two decades about the biochemical properties and expression patterns of these enzymes, a complete understanding of their physiologic roles requires study of their actions in the intact animal. To date only a limited number of naturally occurring human or animal models exhibiting excessive or deficient deiodinase activity have been defined. In particular, no human genetic models of deiodinase deficiency have been identified. However, several transgenic animal models involving either loss-of function or gain-of-function of deiodinase activity have been devised and are currently being characterized. This review focuses on the progress being made in using these animal models to define the physiologic functions and significance of this important class of enzymes.
The Synthetic Cannabinoid R(+)WIN 55,212-2 Inhibits the Interleukin-1 Signaling Pathway in Human Astrocytes in a Cannabinoid Receptor-independent Manner (2005)

R(+)WIN 55,212-2 is a synthetic cannabinoid that controls disease progression in models of multiple sclerosis. This is associated with its ability to reduce migration of leukocytes into the central nervous system. Because leukocyte migration is dependent on induction of adhesion molecules and chemokines by pro-inflammatory cytokines, we examined the effects of R(+)WIN 55,212-2 on their expression. Using 1321N1 astrocytoma and A-172 glioblastoma as cell models we show that R(+)WIN 55,212-2, but not its inactive chiral form S(-)WIN 55,212-2, strongly inhibits the interleukin-1 (IL-1) induction of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and the chemokine IL-8. This inhibition is not mediated via the CB1 or CB2 cannabinoid receptors, because their selective antagonists and pertussis toxin failed to affect the inhibitory effects of R(+)WIN 55,212-2. Furthermore reverse transcription-PCR analysis did not detect the expression of either receptor in 1321N1 cells. R(+)WIN 55,212-2 was shown to inhibit adhesion molecule and chemokine expression at the level of transcription, because it strongly inhibited the IL-1 induction of ICAM-1, VCAM-1, and IL-8 mRNAs and blocked the IL-1 activation of their promoters. The NFkappaB pathway was then assessed as a lead target for R(+)WIN 55,212-2. NFkappaB was measured by expression of a transfected NFkappaB-regulated reporter gene. Using this assay, R(+)WIN 55,212-2 strongly inhibited IL-1 activation of NFkappaB. Furthermore R(+)WIN 55,212-2 inhibited the ability of overexpressed Myd88, Tak-1, and IKK-2 to induce the reporter gene suggesting that R(+)WIN 55,212-2 acts at or downstream of IKK-2 in the IL-1 pathway. However R(+)WIN 55,212-2 failed to inhibit IL-1-induced degradation of IkappaBalpha, excluding IKK-2 as a direct target. In addition electrophoretic mobility shift and chromatin immunoprecipitation assays showed that R(+)WIN 55,212-2 does not regulate the IL-1-induced nuclear translocation of NFkappaB or the ability of the latter to bind to promoters regulating expression of ICAM-1 and IL-8. These data suggest that R(+)WIN 55,212-2 blocks IL-1 signaling by inhibiting the transactivation potential of NFkappaB.
Small bowel infarction by Aspergillus. (1997)

Primary gut involvement by Aspergillus is a rare and often fatal complication of intensive antileukemic therapy. We describe the case of an adult patient affected by acute leukemia who developed a small bowel fungal thromboembolism without radiographic evidence of lung involvement during the post-induction aplastic phase. The diagnosis was made histologically at laparotomy performed for small bowel perforation. The patient died a week later in spite of amphotericin-B treatment and neutrophil recovery. Anti-Aspergillus prophylaxis and early introduction of amphotericin-B in the treatment of febrile neutropenia is probably advisable in all cases of AML.
Staphylococcus aureus (1984)

STAPHYLOCOCCUS aureus has persisted and is now resurging as an important hospital and community pathogen.1 In recent data gathered by the Centers for Disease Control, Staph. aureus finished second behind Escherichia coli as a cause of all types of hospital-acquired infections and essentially equaled that organism in causing hospital-acquired bacteremias.2 Although the exact incidence of community-acquired Staph. aureus sepsis is not known, it continues to be the most common cause of serious progressive skin, soft-tissue, and post-traumatic infections in that setting. Staph. aureus is marvelously equipped as a pathogen, containing biochemical machinery that enables it to colonize quickly and invade . . .
Intracytoplasmic sperm injection for treatment of the infertile male. (1997)

Intracytoplasmic sperm injection (ICSI) with in vitro fertilization represents one of the most significant advances in fertility technology. In this relatively new procedure, a single viable sperm is microinjected into an oocyte that has been extracted transvaginally. After fertilization occurs, the embryo is transferred into the uterus. This procedure now affords men who were previously thought to be irreversibly infertile the chance to initiate their own biologic pregnancy. However, because of the procedure's significant costs and its potential risk to the mother, careful selection of couples following a thorough male factor evaluation is mandatory.
Oral Health and Mortality Risk from Pneumonia in the Elderly (2008)

Although poor oral health influences the occurrence of pulmonary infection in elderly people, it is unclear how the degree of oral health is linked to mortality from pulmonary infection. Therefore, we evaluated the relationship between oral health and four-year mortality from pneumonia in an elderly Japanese population. The study population consisted of 697 (277 males, 420 females) of the 1282 individuals who were 80 years old in 1997. Data on oral and systemic health were obtained by means of questionnaires, physical examinations, and laboratory blood tests. One hundred eight of the study persons died between 1998 and 2002. Of these, 22 deaths were due to pneumonia. The adjusted mortality due to pneumonia was 3.9 times higher in persons with 10 or more teeth with a probing depth exceeding 4 mm (periodontal pocket) than in those without periodontal pockets. Therefore, the increase in teeth with periodontal pockets in the elderly may be associated with increased mortality from pneumonia.
A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction (2011)

ANZ-100 and CRS-207 administration was safe and resulted in immune activation.
Thin, Flexible Sensors and Actuators as ‘Instrumented’ Surgical Sutures for Targeted Wound Monitoring and Therapy (2012)

Proper healing of incised skin is critical to the natural processes of tissue repair. Concepts in flexible silicon electronics enable integration of actuators, sensors and a variety of semiconductor devices onto thin strips of plastic or biopolymers, to yield ‘instrumented’ suture threads for monitoring and accelerating the wound healing in this context. Bifacial systems of this type demonstrate various classes of functionality, in live animal models. Detailed modelling of the mechanics reveals stress and strain distributions in such applications, to support design strategies for robust operation.
Quality of life assessment in palliative care [review] (1994)

Palliative care aims to improve the quality of life of patients through attention to physical, psychological, social and spiritual distress. Assessment of quality of life, expressed as a global score, is difficult because patients are too ill for long interviews, but relatives and professionals are poor proxy respondents for patients. Quality of life assessment tools must be multidimensional, considering both physical and psychosocial issues, must be quick and easy to administer and score and must be sufficiently sensitive to detect changes with time. Quality of life assessment has audit and routine clinical uses; it is an essential consideration in any research involving the patient with advanced cancer. The different types of questionnaire assessment tool are discussed in detail.
Altered Progesterone Receptor Isoform Expression Remodels Progestin Responsiveness of Breast Cancer Cells (2005)

The ovarian hormone progesterone is essential for normal breast development and function. However, it is also implicated in breast cancer development. Progesterone signals through two nuclear receptors [progesterone receptor A (PRA) and progesterone receptor B (PRB)], which display striking differences in transcriptional activity when analyzed separately. The two species are coexpressed equally in normal breast, but expression becomes markedly disrupted in breast cancer, where a predominance of PRA is common. To determine the impact on PR transcriptional activity of the shift from coexpression of PRA and PRB, observed in normal cells, to predominance of PRA, common in cancers, we modeled these changes in PR expression patterns using an inducible model of PRA predominance. At short treatment times progestin regulation was directed toward transcriptional modulators, whereas longer exposure more frequently targeted genes associated with regulation of cell shape, adhesion, and metabolism, and a number of these targets acquired responsiveness only when PRA predominance was achieved. Consistent with this, overexpression of PRA altered progestin effects on cell-substrate attachment and focal adhesion signaling. Our data suggest that disrupted balance of PRA and PRB remodels progestin responsiveness and that altered regulation of morphology and adhesion are important components of altered progestin response in breast cancer.
Anaphylatoxin Formation in Extracorporeal Circuits (1986)

Anaphylatoxin radioimmunoassay techniques have been employed to define both the temporal profile and the amount of complement activation taking place in two different types of extracorporeal circuits. Prospective studies of patients undergoing both maintenance hemodialysis and cardiopulmonary bypass provided essentially similar findings. In both cases, plasma C3a antigen levels proved to be the most accurate and sensitive indicator of intravascular complement activation. By contrast, plasma C5a levels varied little during the period of extracorporeal circulation. Instead, this anaphylatoxin retained considerable biologic activity in vivo as evidenced by its ability to promote granulocyte activation and transient granulocytopenia which was displayed by patients in both groups. Plasma levels of C4a antigen were not elevated during the period of extracorporeal circulation, suggesting that alternative pathway mechanisms were predominantly responsible for the complement activation taking place in both hemodialyzers and bypass oxygenators. However, classical pathway activation events could be documented when protamine sulfate was administered to heparinized patients after cardiopulmonary bypass. In this instance, elevated plasma levels of both C4a and C3a antigens were observed. Prospective studies also suggested that complement activation could be associated with the development of both acute and delayed clinical sequelae. Available data support the hypothesis that C5a anaphylatoxin might be the primary mediator of these undesirable effects of extracorporeal circulation. These types of investigations have contributed significantly to our understanding of the role of the anaphylatoxins in human disease and may be directly applied to facilitate design of more biocompatible medical devices.
Nanoscale fabrication of a single multiwalled carbon nanotube attached atomic force microscope tip using an electric field (2005)

We report a simple, repeatable, reliable method and influential conditions for assembling a single multiwalled nanotube (MWNT) to the end of a metal coated atomic force microscope (AFM) tip. The influential conditions consist of the frequency and magnitude of the induced voltage, the concentration of carbon nanotube (CNT) solution and the shape of the tip’s apex. The optimal experimental factors needed for a single MWNT deposition using the dielectrophoretic force were obtained through repeated experiments. Applying an electric field of 0.6 to 0.7Vpp∕μm at 5 MHz, dropping a droplet of the transparent MWNT solution dispersed in the ethanol in a range of 0.5 to 1μℓ, we obtained a CNT AFM tip with just a single MWNT attached. Furthermore, we found that the curvature of the tip’s apex is a great influential factor in a single MWNT-attached tip. We expect that the appropriate size of curvature can improve the yield of single MWNT attachment. The effectiveness of the MWNT-attached AFM tip is demonstrated by direct comparison with AFM images of a bare AFM tip for a standard sample.
A Novel Role for Keratin 17 in Coordinating Oncogenic Transformation and Cellular Adhesion in Ewing Sarcoma (2013)

Oncogenic transformation in Ewing sarcoma is caused by EWS/FLI, an aberrant transcription factor fusion oncogene. Glioma-associated oncogene homolog 1 (GLI1) is a critical target gene activated by EWS/FLI, but the mechanism by which GLI1 contributes to the transformed phenotype of Ewing sarcoma was unknown. In this work, we identify keratin 17 (KRT17) as a direct downstream target gene upregulated by GLI1. We demonstrate that KRT17 regulates cellular adhesion by activating AKT/PKB (protein kinase B) signaling. In addition, KRT17 is necessary for oncogenic transformation in Ewing sarcoma and accounts for much of the GLI1-mediated transformation function but via a mechanism independent of AKT signaling. Taken together, our data reveal previously unknown molecular functions for a cytoplasmic intermediate filament protein, KRT17, in coordinating EWS/FLI- and GLI1-mediated oncogenic transformation and cellular adhesion in Ewing sarcoma.
Oxidative Damage and Tyrosine Nitration from Peroxynitrite (1996)

ADVERTISEMENT RETURN TO ISSUEPREVOpen ForumNEXTOxidative Damage and Tyrosine Nitration from PeroxynitriteJoseph S. BeckmanView Author Information Departments of Anesthesiology and Biochemistry, The University of Alabama at Birmingham, Birmingham, Alabama 35233 Cite this: Chem. Res. Toxicol. 1996, 9, 5, 836–844Publication Date (Web):July 15, 1996Publication History Received21 August 1995Published online15 July 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/tx9501445https://doi.org/10.1021/tx9501445discussionACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views2376Altmetric-Citations794LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Monomers,Organic reactions,Oxides,Peptides and proteins Get e-Alerts
Evidence for a small catalytic domain in the adenylate cyclase from Salmonella typhimurium. (1983)

Deletions of large portions of the carboxyl-terminal end of the adenylate cyclase (ATP pyrophosphate lyase (cyclizing), EC 4.6.1.1) from Salmonella typhimurium do not significantly affect the enzymatic activity exhibited by the shortened polypeptide. The deletion mutations were generated by nuclease Bal31 digestion from the 3'-end of the cya gene fragment cloned by Wang et al. (Wang, J. Y.-J., Clegg, D. O., and Koshland, D.E. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 4684-4688); the shortened cya genes were inserted in pBR322 and used to transform a cya- strain of Escherichia coli. The original gene fragment encodes for an enzymatically active polypeptide having an apparent molecular weight of 77,000. Mutant polypeptides as small as 46,000 Da were found to retain significant enzymatic activity and to confer several cya+ phenotypes on the E. coli host. More extensive deletions resulting in polypeptides as small as 33,000 Da did not have assayable amounts of adenylate cyclase activity, but the biochemical properties of the transformed cya- host implicate the presence of low levels of enzymatic activity. These data suggest that the structure of the intact enzyme is composed of discrete functional domains. Such a structure for this adenylate cyclase should both facilitate investigations of the chemical mechanism of the reaction and allow structure-function relationships in this physiologically important enzyme to be investigated on a molecular level.
Application of Antioxidants and Other Agents to Prevent Cisplatin Ototoxicity (1999)

Cisplatin ototoxicity appears to be initiated by fee-radical production, which causes depletion of glutathione and antioxidant enzymes in the cochlea, and lipid peroxidation, manifested by an increase in malondialdehyde. These effects were blocked by each of a series of antioxidant compounds given in combination with cisplatin. A mechanism for cisplatin ototoxicity is elaborated with a proposed plan of chemoprevention using agents with different mechanisms of action. These substances could be used alone or in combination to reduce the severity of cisplatin ototoxicity in patients.