gebhart/patrepeval huggingface dataset:
Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog (2001)

1. Metabolism of the analgesic agent, tramadol hydrochloride, was investigated after a single oral administration of 14C-tramadol to four rats (50)mgkg(-1) and two dogs (20)mg kg(-1). 2. Recovery of total radioactivity in rat and dog urine samples over 24 h was 73 and 65% of the radioactive dose, respectively. 3. Unchanged tramadol and a total of 24 metabolites, consisting of 16 Phase I metabolites and eight conjugates (seven glucuromides, one sulphate), were isolated and tentatively identified, which accounted for > 52% of the dose in urine of both species. 4. Of the metabolites, five (M1-5) were previously identified. 5. The metabolites were formed via the following six metabolic pathways: O-demethylation, N-demethylation, cyclohexyl oxidation, oxidative N-dealkylation, dehydration and conjugation. 6. Pathways 1-3 appear to be major steps, forming seven O-desmethyl/N-desmethyl and hydroxy-cyclohexyl metabolites in major quantities. 7. Pathways 1-3 in conjunction with pathway 6 produced four glucuronides along with four minor conjugates. 8. In addition, the in vitro metabolism of tramadol was conducted using rat hepatic S9 fraction in the presence of an NADPH-generating system. Unchanged tramadol (30% of the sample) plus nine metabolites, M1-7, tramadol-N-oxide (M31) and OH-cyclohexyl-M1 (M32), were profiled and tentatively identified based on MS and MS/MS data.
IMGT, the international ImMunoGeneTics database (2001)

IMGT, the international ImMunoGeneTics database, freely available at http://imgt.cines.fr:8104, was created in 1989 at the Université Montpellier II, CNRS, Montpellier, France, and is a high quality integrated information system specialising in immunoglobulins, T cell receptors and major histocompatibility complex molecules of human and other vertebrates. IMGT provides researchers and clinicians with a common access to all nucleotide, protein, genetic and structural immunogenetics data. This information is of high value for medical and veterinary research, biotechnology related to antibody and T cell receptor engineering, genome diversity and evolution studies of the immune response.
Combat Duty in Iraq and Afghanistan, Mental Health Problems, and Barriers to Care (2004)

This study provides an initial look at the mental health of members of the Army and the Marine Corps who were involved in combat operations in Iraq and Afghanistan. Our findings indicate that among the study groups there was a significant risk of mental health problems and that the subjects reported important barriers to receiving mental health services, particularly the perception of stigma among those most in need of such care.
Modular Multilevel Converter for Multifunctional Battery Management System of Electric Vehicle (2018)

Modular multilevel converter (MMC) has become a promising technology for medium/high voltage high power applications. Electric vehicles on the other hand, have a large number of series connected battery cells to enhance the output voltage to drive the connected motor. This paper applies the concept of modular multilevel converter for low power electric vehicle applications where, the batteries of the EV help in exchanging power with the motor. The batteries can discharge when feeding power to the motor and get charged when the motor runs into regenerative mode. Multi-carrier PWM technique is employed to generate the multilevel voltage waveforms and sorting technique is used to balance the battery voltages. Simulation study has been done in MATLAB/SIMULINK platform and it is observed that the voltages and State-of-Charge (SOC) of batteries are well maintained.
A 16Kb electrically erasable nonvolatile memory (1980)

A16K(2K×8) bit electrically-erasable nonvolatile memory (E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> PROM) employing oxides less than 200 Å thick through which electrons tunnel toward or away from a floating polysilicon gate, will be covered.
A Wafer-Scale Digital Integrator Using Restructurable VSLI (1985)

Wafer-scale integration has been demonstrated by fabricating a digital integrator on a monolithic 20-cm/sup 2/ silicon chip, the first laser-restructured digital logic system. Large-area integration is accomplished by laser programming of metal interconnect for defect avoidance. This paper describes the technology for laser welding and cutting, the design methodology and CAD tools developed for wafer-scale integration, and the integrator itself.
Analysis of small nucleolar RNAs in sputum for lung cancer diagnosis (2015)

Molecular analysis of sputum presents a noninvasive approach for diagnosis of lung cancer. We have shown that dysregulation of small nucleolar RNAs (snoRNAs) plays a vital role in lung tumorigenesis. We have also identified six snoRNAs whose changes are associated with lung cancer. Here we investigated if analysis of the snoRNAs in sputum could provide a potential tool for diagnosis of lung cancer. Using qRT-PCR, we determined expressions of the six snoRNAs in sputum of a training set of 59 lung cancer patients and 61 cancer-free smokers to develop a biomarker panel, which was validated in a testing set of 67 lung cancer patients and 69 cancer-free smokers for the diagnostic performance. The snoRNAs were robustly measurable in sputum. In the training set, a panel of two snoRNA biomarkers (snoRD66 and snoRD78) was developed, producing 74.58% sensitivity and 83.61% specificity for identifying lung cancer. The snoRNA biomarkers had a significantly higher sensitivity (74.58%) compared with sputum cytology (45.76%) (P < 0.05). The changes of the snoRNAs were not associated with stage and histology of lung cancer (All P >0.05). The performance of the biomarker panel was confirmed in the testing cohort. We report for the first time that sputum snoRNA biomarkers might be useful to improve diagnosis of lung cancer.
Comparison of the efficacy and safety of combinations of metopimazine or ondansetron with methylprednisolone in the prevention of delayed emesis in patients receiving chemotherapy (2005)

Methopimazine is an effective and well-tolerated alternative to setrons for the treatment of delayed nausea and emesis in patients undergoing chemotherapy.
Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests (1998)

With the current rapid pace at which human disease genes are identified there is a need for practical, cost-efficient genetic screening tests. Two-dimensional electrophoretic separation of PCR-amplified gene fragments on the basis of size and base pair sequence, in non-denaturing and denaturing gradient polyacrylamide gels respectively, provides a rapid parallel approach to gene mutational scanning. Accuracy of the denaturing gradient gel electrophoresis (DGGE) component of this system strongly depends on the design of the PCR primers and the melting characteristics of the fragments they encompass. We have developed a fully automated generally applicable procedure to generate optimal two-dimensional test designs at a minimum amount of time and effort. Designs were generated for the RB1 , TP53 , MLH1 and BRCA1 genes that can be readily implemented in research and clinical laboratories as low cost genetic screening tests.
Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective (2002)

Population-based epidemiologic studies have uncovered the high prevalence and wide severity spectrum of undiagnosed obstructive sleep apnea, and have consistently found that even mild obstructive sleep apnea is associated with significant morbidity. Evidence from methodologically strong cohort studies indicates that undiagnosed obstructive sleep apnea, with or without symptoms, is independently associated with increased likelihood of hypertension, cardiovascular disease, stroke, daytime sleepiness, motor vehicle accidents, and diminished quality of life. Strategies to decrease the high prevalence and associated morbidity of obstructive sleep apnea are critically needed. The reduction or elimination of risk factors through public health initiatives with clinical support holds promise. Potentially modifiable risk factors considered in this review include overweight and obesity, alcohol, smoking, nasal congestion, and estrogen depletion in menopause. Data suggest that obstructive sleep apnea is associated with all these factors, but at present the only intervention strategy supported with adequate evidence is weight loss. A focus on weight control is especially important given the expanding epidemic of overweight and obesity in the United States. Primary care providers will be central to clinical approaches for addressing the burden and the development of cost-effective case-finding strategies and feasible treatment for mild obstructive sleep apnea warrants high priority.
25.9 A &#x00B1;3ppm 1.1mW FBAR frequency reference with 750MHz output and 750mV supply (2015)

Multiple emerging wireless applications (body-worn devices and IoT, for example) will demand previously impossible thin-film form factors and low system cost. One key enabling technology for this paradigm is a new class of radios that offer cost/size approaching RFID while still maintaining peer-to-peer connectivity like more complex radios. These radios need to be cheap and thin, which means they should be fabricated using wafer-scale semiconductor processing. The existing paradigm (quartz crystals used as a frequency reference in radios) is a huge bottleneck in reducing cost and size of these devices. MEMS frequency references have replaced quartz crystals in some applications [1-3]. For example, [1] reports a MEMS reference with 0.5ppm stability but the power consumption (∼100mW) and supply voltage (1.8V) are not suitable for low-voltage/low-power radios. [2] reports a 32kHz, 3ppm reference for mobile time-keeping applications, but is unsuitable for radio frequency synthesis due to its low output frequency. In this paper, we report a thin-Film Bulk-Acoustic-Resonator (FBAR) frequency reference suitable for low-voltage/low-power radio applications. The reported FBAR reference achieves a stability of +/- 3ppm from 0 to 90C. We achieve this by using an electronic temperature compensation scheme to improve the intrinsic +/-50ppm stability of an FBAR oscillator down to +/- 3ppm (Fig. 25.9.1). The core of the temperature compensation scheme is a temperature sensor that achieves a 1.75mK resolution at a 100mS sampling time.
Inhibition of IgE Antibody Formation by Plasmid DNA Immunization Is Mediated by both CD4+ and CD8+ T Cells (1997)

Both CD4+ and CD8+ subsets of T cells from pDNA-immunized mice can suppress IgE antibody production by affecting the primary response and/or by propagating the Th1 memory response in a passive cell transfer system. Immunization with pDNA-encoding allergens may be an effective new form of immunotherapy for atopic diseases.
Anemia and Iron Deficiency — New Therapeutic Targets in Heart Failure? (2009)

Anemia ranges in prevalence from below 10% among patients with mild heart failure symptoms to over 40% for patients with advanced disease.1 Its prevalence is similar among patients who have systolic dysfunction and among patients who have heart failure with preserved systolic function.2,3 Anemia has been associated with older age, diabetes mellitus, chronic renal dysfunction, more advanced heart failure symptoms, lower peak exercise capacity, and worse health-related quality-of-life metrics.3 Anemia has also been shown to be a powerful predictor of rehospitalization rates and survival in chronic heart failure.A complex interaction between impaired cardiac performance, activation of neurohormonal and . . .
Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go? (2012)

In this review we discuss recent progress in the development, testing, and clinical evaluation of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has been made in TB vaccine research and development: from a pipeline virtually empty of new TB candidate vaccines in the early 1990s, to an era in which a dozen novel TB vaccine candidates have been and are being evaluated in human clinical trials. In addition, innovative approaches are being pursued to further improve existing vaccines, as well as discover new ones. Thus, there is good reason for optimism in the field of TB vaccines that it will be possible to develop better vaccines than BCG, which is still the only vaccine available against TB.
Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis (2009)

Cytokine control of the synovial infiltrate is a central process in the development of inflammatory arthritis. In this study, we combine genetic approaches and intervention strategies to describe a fundamental requirement for IL-6-mediated STAT3 signaling in orchestrating the inflammatory infiltrate in monoarticular and systemic models of experimental arthritis. STAT3 activation via the common gp130 signal-transducing receptor for all IL-6-related cytokines led to increased retention of neutrophils and T cells within the inflamed synovium, which included STAT3-regulated IL-17A-secreting T cells. Control of leukocyte infiltration was reliant upon IL-6 signaling via its soluble receptor (termed IL-6 trans signaling), as evidenced by selective blockade of this alternative IL-6 signaling pathway using an engineered variant of soluble gp130 (sgp130Fc). This therapeutic intervention led to substantial clinical improvement in mice with emerging or established incidence of systemic arthritis. These data illustrate that IL-6 control of STAT3 is critical for regulating the synovial infiltrate in inflammatory arthritis, and suggest that selective inhibition of IL-6 trans signaling may provide a more refined intervention strategy for blocking IL-6-driven proarthritic activities.
Plasma Homocysteine and Cardiovascular Disease (2000)

Homocysteine is a sulfur amino acid with a free sulfhydryl group (Fig. 1). It was first discovered by du Vigneaud in 1932 as a product of demethylation of methionine (1). The interest in homocysteine was greatly enhanced by the discovery of the inborn errors, homocystinuria. Homocystinuria means the excretion of large amounts of homocystine, the disulfide of homocysteine, in urine secondary to a high level of homocysteine in blood. This disease was first reported in 1962 by Carson and Neill (2), who identified two siblings, aged 4 and 6 years, among 2081 mentally retarded individuals. Almost simultaneously, Gerritsen et al. (3,4) identified urinary homocystine and documented the absence of cerebral cystathionine in a mentally retarded infant with congenital anomalies and thromboembolism. Mudd and co-workers (5) demonstrated lack of cystathionine fj-synthase activity in liver from a typical patient in 1964. Within a few years after the first cases of cystathionine fj-synthase deficiency were discovered, additional patients and their susceptibility to life-threatening vascular disease were described (6-8). In 1969, McCully (9) described vascular lesions, similar to those observed in cystathionine fj-synthase deficiency, in a 7 112-week-old infant dying of homocystinuria caused by a newly discovered defect in cobalamin metabolism. Similar vascular alterations were reported by Kanwar et al. in 1976 (10) in a 10-year-old girl dying of homocystinuria caused by as,10-methylenetetrahydrofo)ate reductase deficiency.
Biological characterization and oncogene expression in human colorectal carcinoma cell lines (1988)

To establish well-characterized cellular reagents for the study of colon carcinoma, we have examined 19 human colorectal carcinoma cell lines with regard to morphology, ultrastructure, expression of tumor-associated antigens, proliferative capacity in vitro, anchorage-independent growth, oncogene expression, tumorigenicity and malignant potential. Cell lines examined were cultured under identical conditions, and in vitro and in vivo analyses were performed in parallel on replicate cultures. Three classes of colorectal cell lines were defined according to their tumorigenicity in nude mice. Class-1 lines formed rapidly progressing tumors in nearly all mice at an inoculum of 10(6) cells. Cell lines belonging to class-2 were less tumorigenic, producing tumors later and at a slower growth rate. Class-3 lines were non-tumorigenic under all experimental conditions tested. By Northern analysis, the oncogenes c-myc, H-ras, K-ras, N-ras, myb, fos and p53 were expressed in nearly all cell lines examined. In contrast, transcripts for abl, src and ros were not detected. The best in vitro predictor of tumorigenicity was colony formation in soft agar. There was no detectable correlation between tumorigenicity and metastatic potential, doubling time in vitro, production of tumor-associated markers, xenograft histology or expression of specific oncogenes.
Static micromixers based on large-scale industrial mixer geometry (2001)

Mixing liquids at the micro-scale is difficult because the low Reynolds numbers in microchannels and in microreactors prohibit the use of conventional mixing techniques based on mechanical actuators and induce turbulence. Static mixers can be used to solve this mixing problem. This paper presents micromixers with geometries very close to conventional large-scale static mixers used in the chemical and food-processing industry. Two kinds of geometries have been studied. The first type is composed of a series of stationary rigid elements that form intersecting channels to split, rearrange and combine component streams. The second type is composed of a series of short helix elements arranged in pairs, each pair comprised of a right-handed and left-handed element arranged alternately in a pipe. Micromixers of both types have been designed by CAD and manufactured with the integral microstereolithography process, a new microfabrication technique that allows the manufacturing of complex three-dimensional objects in polymers. The realized mixers have been tested experimentally. Numerical simulations of these micromixers using the computational fluid dynamics (CFD) program FLUENT are used to evaluate the mixing efficiency. With a low pressure drop and good mixing efficiency these truly three-dimensional micromixers can be used for mixing of reactants or liquids containing cells in many microTAS applications.
Human erythropoietin gene therapy for patients with chronic renal failure (2005)

Gene therapy holds a major promise. However, until now, this promise was fulfilled only in few cases, in rare genetic diseases. One very common clinical condition is anemia. Patients with anemia of chronic renal failure are treated with erythropoietin. The objective of this study was to develop a therapeutic platform for serum-secreted proteins like erythropoietin. We developed a tissue protein factory based on dermal cores (Biopump) harvested and implanted autologously. In this study, an adenovector was designed to express the human erythropoietin under the control of the cytomegalovirus (CMV) promoter. This vector transduced the harvested dermal cores ex vivo. The transduced cores were implanted, and erythropoietin and reticulocyte counts were measured. Dermal cores were harvested from 13 patients with chronic renal failure, and implantation was performed in 10. There were no significant drug-related side effects to this procedure. Erythropoietin serum levels increased significantly to therapeutic levels from day 1 after implantation reaching a peak during the first week of follow-up. The expression period was transient for up to 14 days. The rise of erythropoietin was followed by a transient significant increase in reticulocyte counts. The decrease of erythropoietin expression coincided with a significant dermal infiltrate of CD8 cytotoxic T cells. Antierythropoietin antibodies were not detected until day 90 following implantation. Implantation of dermal cores ex vivo transduced with human genes could eventually be used in the clinical setting to express therapeutic serum proteins. However, nonimmunogenic delivery system should be tested as gene vehicles.
Twice daily dosing of dabigatran for stroke prevention in atrial fibrillation: a pharmacokinetic justification (2012)

Pharmacokinetic simulations show that a twice daily regimen in patients with AF minimizes daily fluctuations in plasma concentrations of dabigatran and can maintain trough concentrations sufficient to prevent the development of thrombi while at the same time minimizing the risk of bleeding due to supratherapeutic peak plasma concentrations. The efficacy and safety of this dosing regimen is supported by clinical data from the RE-LY trial.
Solving the problem of antibody interference in commercial "sandwich"-type immunoassays of carcinoembryonic antigen. (1989)

We evaluated the effect of human anti-murine antibodies (HAMA) on apparent concentrations of carcinoembryonic antigen (CEA) as measured in serum with commercial enzyme immunoassay (EIA) kits manufactured by Abbot ("two-step" double monoclonal antibody assay), Roche, and Hybritech (room-temperature protocol). In sera from patients given parenteral murine monoclonal antibody for experimental diagnostic and immunotherapy studies, HAMA titers were determined with Immunomedics' "ImmuSTRIP HAMA-EIA" kit reagents. "True" CEA titers were established by using the ImmuCEA/MA-EIA and heat-extraction to destroy HAMA before assay for CEA. The concordance of the ImmuCEA/MA assay with the Abbott and Roche CEA EIAs was established with sera from normal individuals and from patients who had not received parenteral injections of murine monoclonal antibody. At high (100 mg/L) concentrations of HAMA, false-positive results were observed with all three kits. The Hybritech and Roche assays were more sensitive to interference by HAMA than was the Abbott CEA-EIA, false-positive results being observed at HAMA concentrations between 1 and 10 mg/L. Similar sensitivity of the three kits to interference by primate anti-MAb sera was demonstrated. Use of primate anti-MAb sera to create controls with HAMA activity and of analyte is recommended to evaluate MAb assays for potential HAMA interference and for use to devise methods to eliminate HAMA interference.
Capacity of linear multi-user MIMO precoding schemes with measured channel data (2008)

In multi-user multiple-input multiple-output (MU-MIMO) systems, spatial multiplexing can be employed to increase the throughput without the need for multiple antennas and expensive signal processing at the user equipments. In theory, MU-MIMO is also more immune to most of propagation limitations plaguing single-user MIMO (SU-MIMO) systems, such as channel rank loss or antenna correlation. In this paper we compare the performance of different linear MU-MIMO precoding schemes using real channel measurement data. The measurement data has been acquired using Eurecompsilas MIMO Openair Sounder (EMOS). The EMOS can perform real-time MIMO channel measurements synchronously over multiple users. The results show that MU-MIMO provides a higher throughput than SU-MIMO also in the measured channels. However, the throughput in the measured channels is by far worse than the one in channels without spatial correlation. Of all the evaluated linear precoding schemes, the MMSE precoder performs best in the measured channels.