gebhart/patrepeval huggingface dataset:
Effects of the nicotinic acetylcholine receptor agonist SIB‐1508Y on object retrieval performance in MPTP‐Treated monkeys: Comparison with levodopa treatment (1998)

This study assessed the relative potencies of levodopa/benserazide and the nicotinic acetylcholine receptor agonist SIB-1508Y on reversal of cognitive and motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys performing an object retrieval task. Monkeys previously taught to perform this task developed significant cognitive deficits after chronic low-dose MPTP exposure. These monkeys then received additional MPTP treatment to superimpose a parkinsonian movement disorder on their preexisting cognitive deficits. Levodopa/benserazide treatment significantly improved motor aspects of object retrieval performance but did not significantly improve cognition. SIB-1508Y (1 mg/kg) alone did not result in a statistically significant improvement in cognition or motor function in symptomatic MPTP-lesioned animals with deficits in both of these areas. However, the combination of SIB-1508Y and levodopa/benserazide caused significant improvements in both cognition and motor aspects of task performance, and did so at one third to one sixth of the levodopa dose necessary to improve only motor function. These results suggest the potential usefulness of SIB-1508Y and levodopa as adjunctive therapies to improve at least some of the cognitive and motor deficits associated with Parkinson's disease.
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. (1994)

In preclinical studies, a doxorubicin liposome formulation containing polyethylene-glycol (Doxil) shows a long circulation time in plasma, enhanced accumulation in murine tumors, and a superior therapeutic activity over free (unencapsulated) doxorubicin (DOX). The purpose of this study was to characterize the pharmacokinetics of Doxil in cancer patients in comparison with free DOX and examine its accumulation in malignant effusions. The pharmacokinetics of doxorubicin and/or liposome-associated doxorubicin were analyzed in seven patients after injections of equivalent doses of free DOX and Doxil and in an additional group of nine patients after injection of Doxil only. Two dose levels were examined, 25 and 50 mg/m2. When possible, drug levels were also measured in malignant effusions. The plasma elimination of Doxil followed a biexponential curve with half-lives of 2 and 45 h (median values), most of the dose being cleared from plasma under the longer half-life. Nearly 100% of the drug detected in plasma after Doxil injection was in liposome-encapsulated form. A slow plasma clearance (0.1 liter/h for Doxil versus 45 liters/h for free DOX) and a small volume of distribution (4 liters for Doxil versus 254 liters for free DOX) are characteristic of Doxil. Doxorubicin metabolites were detected in the urine of Doxil-treated patients with a pattern similar to that reported for free DOX, although the overall urinary excretion of drug and metabolites was significantly reduced. Doxil treatment resulted in a 4- to 16-fold enhancement of drug levels in malignant effusions, peaking between 3 to 7 days after injection. Stomatitis related to Doxil occurred in 5 of 15 evaluable patients and appears to be the most significant side effect in heavily pretreated patients. The results of this study are consistent with preclinical findings indicating that the pharmacokinetics of doxorubicin are drastically altered using Doxil and follow a pattern dictated by the liposome carrier. The enhanced drug accumulation in malignant effusions is apparently related to liposome longevity in circulation. Further clinical investigation is needed to establish the relevance of these findings with regard to the ability of liposomes to modify the delivery of doxorubicin to solid tumors and its pattern of antitumor activity.
Host–Guest Chemistry of Dendrimer–Drug Complexes: 7. Formation of Stable Inclusions between Acetylated Dendrimers and Drugs Bearing Multiple Charges (2012)

Drug molecules bearing multiple charges usually form precipitates with cationic dendrimers, which presents a challenge during the preparation of dendrimer inclusions for these drugs. In the present study, fully acetylated polyamidoamine (PAMAM) dendrimers were proposed as stable vehicles for drug molecules bearing two negative charges such as Congo red and indocyanine green. NMR techniques including (1)H NMR and (1)H-(1)H NOESY were used to characterize the host-guest chemistry of acetylated dendrimer and these guest molecules. The cationic PAMAM dendrimer was found to form a precipitate with Congo red and indocyanine green, but the acetylated one avoided the formation of cross-linking structures in aqueous solutions. NOESY studies revealed the encapsulation of Congo red and indocyanine green within the interior cavities of PAMAM dendrimers at mild acidic conditions and acetylated dendrimers show much stronger ability to encapsulate the guest molecules than cationic ones. Also, UV-vis-NIR studies suggest that acetylated dendrimers significantly improve the photostability of indocyanine green and prevent the formation of indocyanine green J-aggregates in aqueous solutions. The present study provides a new insight into dendrimer-based host-guest systems, especially for those guest molecules bearing multiple charges.
New rodent models for studies of chemopreventive agents (1997)

Some recent studies of the effects of chemopreventive agents have begun to use new rodent models to improve the analysis of stages of colonic preneoplasia, and how chemopreventive agents modify progressive abnormal cell development. In one of the models of inherited predisposition to colon cancer, mice carrying a truncated Apc allele with a nonsense mutation in exon 15 have been generated by gene targeting and embryonic stem cell technology (Apc1638 mice). These mice develop multiple gastrointestinal lesions, including adenomas and carcinomas, focal areas of high-grade dysplasia (FAD), and polypoid hyperplasias with FADS. The incidence of inherited colonic neoplasms has now been modulated by a chemopreventive regimen. Colonic lesions significantly increased in Apc1638 mice on a Western-style diet, which has higher fat content and lower calcium and vitamin D compared to the same mice on AIN-76A diet. In another rodent model, Min mice were treated with sulindac, which markedly reduced the incidence of intestinal tumors. A third new rodent model containing a targeted mutation in the gene Mcc (mutated in colorectal cancer) recently became available for chemoprevention studies. These mice develop multiple types of neoplasms including adenocarcinomas, focal areas of gastrointestinal dysplasia, papillomas of the forestomach, and tumors in other organs including lung, liver, and lymphoid tissue. Feeding a Western-style diet to the Mcc mutant mice also resulted in significantly increased gastrointestinal lesions. These nutrient modifications also have been given to normal mice, demonstrating without any chemical carcinogen that a Western-style diet induced colonic tumorigenesis. Western-style diets also have now induced modulation of cell proliferation in other organs including mammary gland, pancreas, and prostate. These findings help develop new preclinical rodent models to aid the analysis of genetic and environmental factors leading to neoplasia, as well as new methods for evaluating the chemopreventive efficacy of specific nutrients and pharmacological agents.
Molecular half-subtractor based on 3,3′-bis(1H-benzimidazolyl-2-yl)[1,1′]binaphthalenyl-2,2′-diol (2008)

Title fluorophore (1) possessing 2,2′-binaphthol and benzimidazole moieties has been investigated for elaboration of half-subtractor logic operation. For comparison differently substituted systems have been studied. Fluorophore 1 showed strong fluorescence at 585 nm due to ESIPT phenomena which was completely quenched on addition of HClO4 with concomitant appearance of a new emission band at 435 nm with hypsochromic shift of 150 nm. The addition of TBAOH to the solution of 1 gave a new hypsochromically shifted emission band at 515 nm (Δλ = 70 nm) with concomitant quenching at 585 nm. Thus, fluorophore 1 with large differentials of emission maxima under neutral, acidic and basic conditions provides four opportunities for arithmetic operation half-subtractor. i.e. with 435/515 nm (INHIBIT) and 475 nm (XOR) gates and with 435/515 nm (INHIBIT) and 585 nm (XNOR) gates which have been elaborated as combinatorial logic circuits for a molecular half-subtractor with acid and base as input variables. The elaboration of half-subtractor with only XOR logic in the case of fluorophore 2 possessing a molecular structure half that of fluorophore 1 and complete lack of logic gates in fluorophore 5 with change in position of benzimidazole moiety further signify the importance of the structural architecture in fluorophore 1.
Syntonic wireless telegraphy; with specimens of large-scale measurements (1909)

Abstract The absence of effective tuning is one of the marked features of wireless telegraphy as at present usually conducted in practice. In many cases messages are disentangled from a crowd of superposed disturbances, i. e. from other messages, largely by the skill of the receiving telegraphic operator, who, by the exercise of selective attention, manages to interpret and read what is intended for him ; the process being identical with the ordinary human faculty whereby a conversation can be listened to amid general talking and a crowd of other noises at a dinner table.
Characterization of Lytic Enzyme Open Reading Frame 9 (ORF9) Derived from Enterococcus faecalis Bacteriophage φEF24C (2010)

In bacteriophage (phage) therapy against Gram-positive bacteria, such as Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis, members of a genus of SPO1-like viruses are typically employed because of their extreme virulence and broad host spectrum. Phage φEF24C, which is a SPO1-like virus infecting E. faecalis, has previously been characterized as a therapeutic phage candidate. In addition to the phage itself, phage endolysin is also recognized as an effective antimicrobial agent. In this study, a putative endolysin gene (orf9) of E. faecalis phage φEF24C was analyzed in silico, and its activity was characterized using the recombinant form. First, bioinformatics analysis predicted that the open reading frame 9 (ORF9) protein is N-acetylmuramoyl-l-alanine amidase. Second, bacteriolytic and bactericidal activities of ORF9 against E. faecalis were confirmed by zymography, decrease of peptidoglycan turbidity, decrease of the viable count, and morphological analysis of ORF9-treated cells. Third, ORF9 did not appear to require Zn(2+) ions for its activity, contrary to the bioinformatics prediction of a Zn(2+) ion requirement. Fourth, the lytic spectrum was from 97.1% (34 out of 35 strains, including vancomycin-resistant strains) of E. faecalis strains to 60% (6 out of 10 strains) of Enterococcus faecium strains. Fifth, N-acetylmuramoyl-l-alanine amidase activity of ORF9 was confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and the subsequent MALDI-postsource decay (PSD) analyses. Finally, functional analysis using N- or C-terminally deleted ORF9 mutants suggested that a complete ORF9 molecule is essential for its activity. These results suggested that ORF9 is an endolysin of phage φEF24C and can be a therapeutic alternative to antibiotics.
Genotype Dependence of Hepatitis C Virus Load Measurement in Commercially Available Quantitative Assays (1999)

Standardization and genotype independence of methods used to quantify hepatitis C virus (HCV) RNA in clinical specimens are necessary for accurate assessment of the role of HCV quantitation as a prognostic marker for HCV infection and monitoring of the response to antiviral treatment. Commercially available methods used to measure HCV loads include PCR-based (Roche Monitor) and hybridization-based (Quantiplex bDNA-2) methods. Recently, a new version of the Roche Monitor assay (version 2.0) has become available; it has been modified to achieve more equal quantitation of different HCV genotypes. Consistent with previous reports, Roche Monitor version 1.0 substantially underestimated concentrations of RNA transcripts of types 2b, 3a, 4a, 5a, and 6a and virus loads in individuals infected with genotypes 2 to 6 relative to reference tests. However, version 2.0 achieved equivalent quantitation of each genotype over a narrow quantitative range (10(3) to 5 x 10(5) copies of RNA/ml) but significantly underestimated RNA concentrations above this range. The assay showed an equivalent inability to quantify high levels of HCV RNA in plasma samples, and this was responsible for the falsely narrow range of virus loads detected in HCV-infected individuals. In contrast, the Chiron bDNA-2 assay could only measure RNA concentrations in the upper quantitative range (2 x 10(5) to 5 x 10(7) copies of RNA/ml) but showed equivalent sensitivity for genotypes 1 to 5; however, concentrations of type 6a RNA transcripts and virus loads in clinical specimens from individuals infected with type 6a were underestimated by a factor of 2 to 4. Differences were observed between PCR- and hybridization-based assays in their relative quantitation of HCV RNA transcripts and HCV genomic RNA, which may cause problems with the use of transcripts for interassay calibration.
Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis. (1994)

We have developed an efficient in vitro transformation system using N-methyl-N-nitrosourea that allows us to study the role of hormones and growth factors in mouse mammary tumorigenesis. Utilizing this system, we reported earlier that mammary tumors induced in vitro with N-methyl-N-nitrosourea in the presence of mammogenic hormones (progesterone and prolactin) contain predominately an activated c-Ki-ras protooncogene with a G35 --> A35 transitional mutation in the 12th codon. Mammary tumors induced in the presence of another mitogen, lithium (Li), do not have a mutation in the c-Ki-ras protooncogene. By using an expression cloning system, a plasmid clone containing a 1.75-kb cDNA insert has been isolated from this group of tumors. Nucleic acid sequence analysis of the insert reveals that it has a short open reading frame of 61 amino acids and that it does not have sequence homology with any known gene. The gene, designated MAT1, can neoplastically transform NIH 3T3 cells and also the mammary epithelial cell line TM3. Expression of this gene occurs in normal mouse tissues including mammary gland and is overexpressed in the original mammary tumors as indicated by Northern blot analysis. In vitro transcription and translation of the clone shows a protein product of 6000 Da, which agrees with the predicted open reading frame.
Servo error signal generation for two-photon-recorded monolithic multilayer optical data storage (2000)

Closed-loop tracking control using fluorescent signal power on a bi-cell detector has been demonstrated on 2-photon recorded data tracks. A similar focus control technique also appears promising. This is the first demonstration, to the authors' knowledge, of an operational tracking servo in 2-photon recorded media.
Texture and grain morphology dependencies of saturation magnetostriction in rolled polycrystalline Fe83Ga17 (2003)

Textured polycrystalline Fe-Ga alloys exhibit magnetostrictive strains of 100 ppm or greater and may function as a mechanically robust actuator/sensing material. Current efforts seek to combine the 300+ ppm magnetostrictive strain performance of [100] oriented single crystals with the mechanical properties of polycrystalline forms. One approach to combining these properties is to control the crystallographic texture through deformation processing such as rolling. To determine the relationship between saturation magnetostriction, degree of texturing, and grain morphology we compare the results of three-dimensional finite element simulations with the analytical solution for a random polycrystal and the experimental responses of rolled polycrystalline Fe83Ga17. Textured specimens were produced through rolling reductions up to 99% of an as-cast ingot and a subsequent 1100 or 590 °C anneal. The high temperature anneal produced a recrystallized grain structure having a wide variation in crystal orientation as determined by orientation imaging microscopy. This recrystallized specimen exhibited a net magnetostriction of ∼170 ppm in the rolling direction and was well correlated with the finite element model result. The low temperature annealed specimen possessed fine elongated grains having dispersed {001}〈110〉 and {111}〈211〉 textures. Net magnetostrictions of 30 and 37 ppm were measured in the rolling direction and 45° off the rolling direction, respectively. The low magnetostriction value in the 45° direction disagrees substantially with the finite element solution of 157 ppm and suggests that unknown factors are dominating the response.
Introduction: Lineages, Techniques, Training and Tradition (2008)

Sustained and wide-ranging approach to the subject.of Australian performance is offered. The range and diversity of approaches to actor training in Australia is analysed and the issues that make the performance the performer's cultural heritage, a particular training, and a certain kind of physicality, is addressed.
Building logical qubits in a superconducting quantum computing system (2017)

Abstract The technological world is in the midst of a quantum computing and quantum information revolution. Since Richard Feynman’s famous ‘plenty of room at the bottom’ lecture (Feynman, Engineering and Science 23 , 22 (1960)), hinting at the notion of novel devices employing quantum mechanics, the quantum information community has taken gigantic strides in understanding the potential applications of a quantum computer and laid the foundational requirements for building one. We believe that the next significant step will be to demonstrate a quantum memory, in which a system of interacting qubits stores an encoded logical qubit state longer than the incorporated parts. Here, we describe the important route towards a logical memory with superconducting qubits, employing a rotated version of the surface code. The current status of technology with regards to interconnected superconducting-qubit networks will be described and near-term areas of focus to improve devices will be identified. Overall, the progress in this exciting field has been astounding, but we are at an important turning point, where it will be critical to incorporate engineering solutions with quantum architectural considerations, laying the foundation towards scalable fault-tolerant quantum computers in the near future.
Geodesic Polyarenes by Flash Vacuum Pyrolysis (2006)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeodesic Polyarenes by Flash Vacuum PyrolysisVikki M. Tsefrikas and Lawrence T. ScottView Author Information Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467 Cite this: Chem. Rev. 2006, 106, 12, 4868–4884Publication Date (Web):November 9, 2006Publication History Received8 May 2006Published online9 November 2006Published inissue 1 December 2006https://pubs.acs.org/doi/10.1021/cr050553yhttps://doi.org/10.1021/cr050553yresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views5397Altmetric-Citations666LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon nanomaterials,Cyclization,Hydrocarbons,Hydrogen,Precursors Get e-Alerts
Business Intelligence (2004)

Business intelligence systems combine operational data with analytical tools to present complex and competitive information to planners and decision makers. The objective is to improve the timeliness and quality of inputs to the decision process. Business Intelligence is used to understand the capabilities available in the firm; the state of the art, trends, and future directions in the markets, the technologies, and the regulatory environment in which the firm competes; and the actions of competitors and the implications of these actions. The emergence of the data warehouse as a repository, advances in data cleansing, increased capabilities of hardware and software, and the emergence of the web architecture all combine to create a richer business intelligence environment than was available previously. Although business intelligence systems are widely used in industry, research about them is limited. This paper, in addition to being a tutorial, proposes a BI framework and potential research topics. The framework highlights the importance of unstructured data and discusses the need to develop BI tools for its acquisition, integration, cleanup, search, analysis, and delivery. In addition, this paper explores a matrix for BI data types (structured vs. unstructured) and data sources (internal and external) to guide research.