gebhart/patrepeval huggingface dataset:
Circulating antibodies to the surface antigens on colon epithelial cells in ulcerative colitis. (1983)

The fluorescence activated cell sorter (FACS) was used for detecting circulating antibodies to the surface antigens on isolated colon epithelial cells (anti-colon antibodies) by indirect immunofluorescence. Anti-colon antibodies were found in the serum of 30 of 41 (73%) patients with ulcerative colitis. This incidence is much higher than one established in earlier reports by application of indirect immunofluorescence to colon tissue using the fluorescence microscope. The results suggest that FACS analysis is very useful for detecting antibodies to colon specific antigen.
Patrones de viajes turísticos e impactos regionales: aspectos y ejemplos de Nueva Zelanda (1993)

espanolNueva Zelanda desea incrementar el total de arribos por turismo internacional para lograr asi un aumento de divisas. Sin embargo, la relacion aumento de turistas igual a mayores ingresos no se refleja en forma uniformea nivel regional. Este estudio se concentra en los patrones de viaje y en el impacto economico del turismo internacional. portuguesA Nova Zelanda deseja aumentar o total de cegadas por causa do turismo internacional para ver assim aumentado as suas divisas. No entanto, a relacao aumento de turistas e maiores receitas nao se ve refleitada de maneira uniforme a nivel regional. Este estudo concentra-se nos padroes de viajem e no impacto economico do turismo internacional, sem por isso desconhecer a possibilidade de apresentar situacoes semelhantes a respeito de turismo domestico.
The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus. (1989)

Most uropathogenic strains of Escherichia coli produce heteropolymeric organelles, known as P pili, that bind to the globoseries of glycolipids present in the urinary tract. The formation of a P pilus is the result of a family of related proteins being coordinately assembled into the structure in a defined order with the adhesin located exclusively at the tip. The preassembled digalactoside alpha-D-galactopyranosyl-(1----4)-beta-D-galactopyranose-binding adhesin was purified to homogeneity from the periplasmic space in a complex with the periplasmic assembly protein PapD by affinity chromatography to alpha-D-galactopyranosyl-(1----4)-beta-D-galactopyranose-Sepharose. A receptor-binding domain was mapped to the amino-terminal half of the adhesin. The interaction of PapD with PapG, which was required for the incorporation of the adhesin into the pilus, was found to protect PapG from proteolytic cleavages and enhanced the processing of the PapG signal peptide. A preassembly domain necessary for forming a complex with PapD was mapped to the carboxyl terminus of PapG.
Dysphagia and Respiratory Infections in Acute Ischemic Stroke (2012)

Eating and swallowing are activities that are normally performed without conscious thought. This complex behaviour -involving 5 pairs of cranial nerves and 26 pairs of muscles -can be interrupted by a stroke, leading to dysphagia. Dysphagia is associated with aspiration (where material passes into the respiratory tract) and aspiration carries a risk of pneumonia seven times greater than that of the normal population. Around 15% -20% of all stroke patients will develop respiratory tract infections during the acute phase of their stroke. Pneumonia is one of the leading causes of mortality in the acute stroke patient. Respiratory infections add to hospital length of stay and are associated with significant increases in the cost of patient care, as well as being associated with poorer outcomes for the patient. This chapter will outline the association of dysphagia and other risk factors in the development of respiratory infections in acute ischemic stroke patients.
BioRuby: bioinformatics software for the Ruby programming language (2010)

katayama@bioruby.org
Loudon Surfactant Flood Pilot Test (1982)

Abstract A successful surfactant (microemulsion) flood pilot test has been completed by Exxon in a watered-out portion of the Weiler sand, Loudon Field, Fayette County, Illinois. The microemulsion system tested was designed to be effective in the presence of high-salinity formation water containing 104,000 ppm (mg/1) total dissolved solids (TDS) without use of a preflush. The test was conducted in a single, 0.68-acre 5-spot operated to approximate a confined pattern. Approximately 60 percent of the waterflood residual oil present in the pilot pattern was recovered. Extensive data for determining sweep and displacement efficiencies were obtained from observation well logs and fluid tracers. Although problems were encountered with bacterial degradation of biopolymer and with produced oil-water emulsions, the test is considered to be a technical success and confirms the effectiveness of the high-salinity microemulsion formulation. Additional pilot tests are needed to determine the effects on oil recovery of microemulsion bank size and well spacing.
Taming the underlying challenges of reliable multihop routing in sensor networks (2003)

The dynamic and lossy nature of wireless communication poses major challenges to reliable, self-organizing multihop networks. These non-ideal characteristics are more problematic with the primitive, low-power radio transceivers found in sensor networks, and raise new issues that routing protocols must address. Link connectivity statistics should be captured dynamically through an efficient yet adaptive link estimator and routing decisions should exploit such connectivity statistics to achieve reliability. Link status and routing information must be maintained in a neighborhood table with constant space regardless of cell density. We study and evaluate link estimator, neighborhood table management, and reliable routing protocol techniques. We focus on a many-to-one, periodic data collection workload. We narrow the design space through evaluations on large-scale, high-level simulations to 50-node, in-depth empirical experiments. The most effective solution uses a simple time averaged EWMA estimator, frequency based table management, and cost-based routing.
A linear algebra framework for automatic determination of optimal data layouts (1999)

This paper presents a data layout optimization technique for sequential and parallel programs based on the theory of hyperplanes from linear algebra. Given a program, our framework automatically determines suitable memory layouts that can be expressed by hyperplanes for each array that is referenced. We discuss the cases where data transformations are preferable to loop transformations and show that under certain conditions a loop nest can be optimized for perfect spatial locality by using data transformations. We argue that data transformations can also optimize spatial locality for some arrays without distorting temporal/spatial locality exhibited by others. We divide the problem of optimizing data layout into two independent subproblems: 1) determining optimal static data layouts, and 2) determining data transformation matrices to implement the optimal layouts. By postponing the determination of the transformation matrix to the last stage, our method can be adapted to compilers with different default layouts. We then present an algorithm that considers optimizing parallelism and spatial locality simultaneously. Our results on eight programs on two distributed shared-memory multiprocessors, the Convex Exemplar SPP-2000 and the SGI Origin 2000, show that the layout optimizations are effective in optimizing spatial locality and parallelism.
Convenient and Efficient Pd‐Catalyzed Regioselective Oxyfunctionalization of Terminal Olefins by Using Molecular Oxygen as Sole Reoxidant (2005)

Just the one: The combination of palladium dichloride and N,N-dimethylacetamide (DMA) constitutes a highly efficient and reusable catalytic system, which uses molecular oxygen as the sole reoxidant for liquid-phase Wacker oxidation and acetoxylation of terminal olefins to the corresponding methyl ketones and linear allylic acetates, respectively (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z502886_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation. (1985)

Saccharomyces cerevisiae contains two genes with remarkable homology to members of the ras oncogene family. These two genes, RAS1 and RAS2, constitute an essential gene family since spores with disruptions of both genes fail to grow. We report here that strains containing RAS2 disruptions have three distinct phenotypes. First, they fail to grow efficiently on nonfermentable carbon sources. Second, they hyperaccumulate the storage carbohydrates glycogen and trehalose. Third, diploid cells homozygous for the RAS2 disruptions sporulate on rich media. Extragenic suppressors have been isolated that suppress the gluconeogenic defect. These suppressors fall into at least three complementation groups, mutations in two of which bypass the normal requirement of RAS for cell viability, allowing cells containing neither RAS gene to grow. The phenotype of the RAS2 mutant and extragenic suppressors implicate RAS with some function in the normal response to nutrient limitation.
Effect of doping TiO2 with alkaline-earth metal ions on its photocatalytic activity (2007)

TiO2 photocatalysts doped with alkaline-earth metal ions were prepared by the impregnation and coprecipitation methods. The sample were characterized by XRD, XPS and IR spectroscopy. Their activities were evaluated by the photocatalytic production of hydrogen. The activities of the doped photocatalysts dopended on the size of the dopant ions and the doping method. The optimum molar contents of dopant ions Be2+, Mg2+, Ca2+, Sr2+, Ba2+ were 1.25, 1.25, 2.25, 2.25 and 2.25 at. %, respectively. The optimum calcination temperature and time were 400?C and 1 h. .
Effects of substratum morphology on cell physiology (1994)

Among the host of substratum properties that affect animal cell behavior, surface morphology has received relatively little attention. The earliest effect of surface morphology on animal cells was discovered almost a century ago when it was found that cells became oriented in response to the underlying topography. This phenomenon is now commonly known as contact guidance. From then until very recently, little progress has been made in understanding the role of surface morphology on cell behavior, primarily due to a lack of defined surfaces with uniform morphologies. This problem has been solved recently with the development of photolithographic techniques to prepare substrata with well defined and uniform surface morphologies. Availability of such surfaces has facilitated systematic in vitro experiments to study influence of surface morphology on diverse cell physiological aspects such as adhesion, growth, and function. For example, these studies have shown that surfaces with uniform multiples parallel grooves can enhance cell adhesion by confining cells in grooves and by mechanically interlocking them. Several independent studies have demonstrated that cell shape is a major determinant of cell growth and function. Because surface morphology has been shown to modulate the extent of cell spreading and cell shape, its effects on cell growth and function appear to be mediated via this biological coupling between cell shape and function. New evidence in the cell biology literature is emerging to suggest that surface morphology could affect other cell behavioral properties such as post-translational modifications. Further elucidation of such effects will enable better designs for implant and cell culture substrata.
The Role of Recombinant Erythropoietin for the Treatment of Anemia in Multiple Myeloma (1998)

The key role of a blunted production of endogenous erythropoietin (EPO) in determining anemia of patients with multiple myeloma (MM) has been definitively established. Thus, several clinical trials have investigated the effects of recombinant EPO (r-EPO) in anemic MM patients. The results of these studies have demonstrated that r-EPO is a safe and effective drug, which results in an increase in Hb levels in the majority of treated patients. However, several factors, such as serum levels of endogenous EPO, severity of anemia, presence of normal erythroid progenitors, serum levels of some cytokines with inhibitory activity on erythroid function and previous treatments, may significantly affect the possibility of response, thereby suggesting the need for careful selection of MM patients for treatment with r-EPO.
Parallel symbolic execution for structural test generation (2010)

Symbolic execution is a popular technique for automatically generating test cases achieving high structural coverage. Symbolic execution suffers from scalability issues since the number of symbolic paths that need to be explored is very large (or even infinite) for most realistic programs. To address this problem, we propose a technique, Simple Static Partitioning, for parallelizing symbolic execution. The technique uses a set of pre-conditions to partition the symbolic execution tree, allowing us to effectively distribute symbolic execution and decrease the time needed to explore the symbolic execution tree. The proposed technique requires little communication between parallel instances and is designed to work with a variety of architectures, ranging from fast multi-core machines to cloud or grid computing environments. We implement our technique in the Java PathFinder verification tool-set and evaluate it on six case studies with respect to the performance improvement when exploring a finite symbolic execution tree and performing automatic test generation.
Recent developments on dry eye disease treatment compounds (2013)

Dry eye syndrome is a common tears and ocular surface multifactorial disease, described by changes in the ocular surface epithelia related to reduced tears quantity and ocular surface sensitivity, leading to inflammatory reaction. Managing the eye inflammation proved helpful to patients with dry eye disease and current treatment is based on the use of topically applied artificial tear products/lubricants, tear retention management, stimulation of tear secretion and using anti-inflammatory drugs. In this article we revise the corresponding literature and patents assembling the new treatment approaches of novel and future pharmaceutical compounds destined for the dry eye disease treatment. The most frequent categories of compounds presented are secretagogues and anti-inflammatory drugs. These compounds are the research outcome of novel therapeutic strategies designed to reduce key inflammatory pathways and restore healthy tear film.
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations (2000)

Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome. This effect, rather than depending on ligand-induced receptor oligomerization, was found to stem from ligand- independent interaction of wild-type and mutant Fas receptors through a specific region in the extracellular domain. Preassociated Fas complexes were found in living cells by means of fluorescence resonance energy transfer between variants of green fluorescent protein. These results show that formation of preassociated receptor complexes is necessary for Fas signaling and dominant interference in human disease.
The bis(bipyridine)copper(II)-induced activation of dioxygen for the catalytic dehydrogenation of alcohols (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe bis(bipyridine)copper(II)-induced activation of dioxygen for the catalytic dehydrogenation of alcoholsXiu Liu, Aimin Qiu, and Donald T. SawyerCite this: J. Am. Chem. Soc. 1993, 115, 8, 3239–3243Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00061a023https://doi.org/10.1021/ja00061a023research-articleACS PublicationsRequest reuse permissionsArticle Views711Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Software for enhanced monitoring in integrated substations (2004)

Substation data integration is facilitated by existence and appropriate connection of intelligent electronic devices (IED). Collecting data from IEDs and its processing facilitates performing data consistency checks, filtering out erroneous measurements, monitoring of switching sequences and substation topology transitions etc. Processed data may be used locally and/or communicated to remote sites (neighboring substations and/or control centers). The paper presents software that implements substation data integration and performs processing and monitoring functions. Generated output is made available for exchange with other applications. The emphasis of data processing is on utilization of redundancy in local measurements to enhance reliability of the monitoring functions in integrated substations.
The Complete Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis ssp. lactis IL1403 (2001)

Lactococcus lactis is a nonpathogenic AT-rich gram-positive bacterium closely related to the genus Streptococcus and is the most commonly used cheese starter. It is also the best-characterized lactic acid bacterium. We sequenced the genome of the laboratory strain IL1403, using a novel two-step strategy that comprises diagnostic sequencing of the entire genome and a shotgun polishing step. The genome contains 2,365,589 base pairs and encodes 2310 proteins, including 293 protein-coding genes belonging to six prophages and 43 insertion sequence (IS) elements. Nonrandom distribution of IS elements indicates that the chromosome of the sequenced strain may be a product of recent recombination between two closely related genomes. A complete set of late competence genes is present, indicating the ability of L. lactis to undergo DNA transformation. Genomic sequence revealed new possibilities for fermentation pathways and for aerobic respiration. It also indicated a horizontal transfer of genetic information from Lactococcus to gram-negative enteric bacteria of Salmonella-Escherichia group.
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs (1998)

Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase 3 (GRK3) to explore the in vivo role of this GRK in cardiac function. GRK3 is expressed in the heart along with the beta-adrenergic receptor kinase (beta-ARK1) and GRK5. We have previously demonstrated that myocardial-targeted overexpression in transgenic mice of beta-ARK1 (Koch, W.J., H. A. Rockman, P. Samama, R. A. Hamilton, R. A. Bond, C. A. Milano, and R. J. Lefkowitz. Science 268: 1350-1353, 1995) or GRK5 (Rockman, H.A., D.-J. Choi, N. U. Rahman, S. A. Akhter, R. J. Lefkowitz, and W. J. Koch. Proc. Natl. Acad. Sci. USA 93: 9954-9959, 1996) results in significant attenuation of beta-adrenergic signaling and in vivo cardiac function and selective desensitization of angiotensin (ANG) II-mediated cardiac responses. Surprisingly, myocardial overexpression of GRK3 resulted in normal biochemical signaling through beta-adrenergic receptors (beta-ARs), and in vivo hemodynamic function in response to a beta-AR agonist was indistinguishable from that in nontransgenic controls. Furthermore, in vivo signaling and functional responses to ANG II were unaltered. However, myocardial thrombin signaling, as assessed by p42/p44 mitogen-activated protein (MAP) kinase activation, was significantly attenuated in GRK3 transgenic mouse hearts, indicating a distinct in vivo substrate specificity for GRK3.
The molecular origin of DNA-drug specificity in netropsin and distamycin. (1985)

X-ray analysis of the complex of netropsin with the B-DNA dodecamer of sequence C-G-C-G-A-A-T-T-BrC-G-C-G reveals that the antitumor antibiotic binds within the minor groove by displacing the water molecules of the spine of hydration. Netropsin amide NH furnish hydrogen bonds to bridge DNA adenine N-3 and thymine O-2 atoms occurring on adjacent base pairs and opposite helix strands, exactly as with the spine of hydration. The narrowness of the groove forces the netropsin molecule to sit symmetrically in the center, with its two pyrrole rings slightly non-coplanar so that each ring is parallel to the walls of its respective region of the groove. Drug binding neither unwinds nor elongates the double helix, but it does force open the minor groove by 0.5-2.0 A, and it bends back the helix axis by 8 degrees across the region of attachment. The netropsin molecule has an intrinsic twist that favors insertion into the minor groove of B-DNA, and it is given a small additional twist upon binding. The base specificity that makes netropsin bind preferentially to runs of four or more A X T base pairs is provided not by hydrogen bonding but by close van der Waals contacts between adenine C-2 hydrogens and CH groups on the pyrrole rings of the drug molecule. Substitution of one or more pyrroles by imidazole could permit recognition of G X C base pairs as well, and it could lead to a class of synthetic "lexitropsins," capable of reading any desired short sequence of DNA base pairs.