gebhart/patrepeval huggingface dataset:
XIII. Mitteil. über katalytische Oxydationen. Die Darstellung der L‐Gulose (1958)

Abstract L ‐Gulose läßt sich direkt durch katalytische Oxydation von D ‐Sorbit am Platin‐Aktivkohle‐Kontakt mit Sauerstoff darstellen. Die Isolierung erfolgt als Benzylphenylhydrazon, nachdem die bei der Oxydation gebildeten Säuren mittels Austauschers und zugleich entstehende Glucose und Fructose durch Vergärung abgetrennt worden sind.
Synaptic plasticity in animal models of early Alzheimer's disease (2003)

Amyloid beta-protein (Abeta) is believed to be a primary cause of Alzheimer's disease (AD). Recent research has examined the potential importance of soluble species of Abeta in synaptic dysfunction, long before fibrillary Abeta is deposited and neurodegenerative changes occur. Hippocampal excitatory synaptic transmission and plasticity are disrupted in transgenic mice overexpressing human amyloid precursor protein with early onset familial AD mutations, and in rats after exogenous application of synthetic Abeta both in vitro and in vivo. Recently, naturally produced soluble Abeta was shown to block the persistence of long-term potentiation (LTP) in the intact hippocampus. Sub-nanomolar concentrations of oligomeric Abeta were sufficient to inhibit late LTP, pointing to a possible reason for the sensitivity of hippocampus-dependent memory to impairment in the early preclinical stages of AD. Having identified the active species of Abeta that can play havoc with synaptic plasticity, it is hoped that new ways of targeting early AD can be developed.
Cu (In,Ga)Se2 thin films and solar cells prepared by selenization of metallic precursors (1996)

CuIn(1−x)GaxSe2 (CIGS) thin films with Ga ratio, x, ranging from 0.55 to 0.75 were grown on Mo/glass substrates by the selenization of metallic precursors in a H2Se atmosphere. Without a postdeposition annealing step the films were found to have a highly graded composition that became Ga rich near the absorber/Mo interface. A high-temperature annealing step promoted diffusion of Ga to the surface region of the films. These absorbers were used to fabricate glass/Mo/CIGS/CdS/ZnO thin-film solar cells with open-circuit voltages ranging from 0.4 to 0.74 V and efficiencies approaching 12%. Devices, as well as the absorber layers, were characterized.
Retinal Abnormalities in Early Alzheimer’s Disease (2007)

Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins. The results show that AD produces quantifiable abnormalities in the retina.
Nanocrystallisation of an Fe44.5Co44.5Zr7B4amorphous magnetic alloy (2006)

The crystallisation of amorphous Fe44.5Co44.5Zr7B4 was investigated using DSC, electrical resistivity, TEM, HRTEM, CBED and VSM. Melt-spun amorphous Fe44.5Co44.5Zr7B4 crystallised by the primary crystallisation mode: the DSC results showed two exothermal peaks during heating. The electrical resistivity dropped sharply during the crystallisation event, which was consistent with DSC characterisation. From TEM, HRTEM and CBED results, primary crystallisation products which appeared to be clusters of crystals were found to be single crystal precipitates; these crystals formed in a compact dendritic morphology. Direct measurement of nucleation density and volume fraction was carried out using TEM analysis. The nucleation density was found to be high even in the absence of copper addition. The crystal growth was slow when the average size reached around 30 nm; this resulted in a stable nanocrystalline structure. The soft magnetic properties were improved after nanocrystallisation, the magnetic properties were related to the crystalline volume fraction and the Herzer model.
GABAergic and Glutamatergic Modulation in Binge Eating: Therapeutic Approach (2011)

Lifetime prevalence estimates for binge eating disorder (BED) and bulimia nervosa (BN) are 3.5% and 1.5% among women and 2.0% and 0.5% among men, respectively. Night eating syndromes (NES) affect 1.1%-1.5% of the general population. All of these disorders induce an impaired quality of life and significant disability. Symptom overlaps are reported between substance use disorders and eating disorders such as BED, BN and NES. A growing body of evidence suggests that γ-amino-butyric acid (GABA) and glutamate modulation pathways might be useful targets in the treatment of alcohol and substance use disorders. Their involvement in the reward process and in the regulation of food intake could be the source of new pharmacological strategies for the treatment of eating disorders. We review published data on the efficacy and safety of drugs targeting the GABA and glutamate modulation pathways for the treatment of BED, BN and NES. Preliminary results indicate that baclofen and topiramate are effective in reducing binge eating, craving and weight gain. However, the potential clinical drug-placebo difference is not detected for acamprosate and lamotrigine. Limitations of these studies are discussed. In view of these data, first- and second-line pharmacological interventions are proposed.
Dynamic Tracking of Cardiac Vulnerability by Complex Demodulation of the T Wave (1991)

A link is found between T wave alternans and vulnerability to ventricular fibrillation, and a new approach is provided for quantification of susceptibility to malignant arrhythmias. Complex demodulation reveals that alternation of the electrocardiogram is concentrated during the first half of the T wave, coinciding with the vulnerable period of the cardiac cycle. During myocardial ischemia and reperfusion, there are marked increases in the degree of T wave alternans that parallel the established time course of changes in vulnerability. The influence of the sympathetic nervous system in arrhythmogenesis is also accurately detected. Ultimately, complex demodulation of the electrocardiogram could provide a technique for identification and management of individuals at risk for sudden cardiac death.
Nano-scaled inorganic/biopolymer composites: Molecular modeling vistas (2005)

Mg/Al hydrotalcite (HT) is biocompatible [1], and has found pharmaceutical applications as antacid [2], ingredient in sustained-release pharmaceuticals containing nifedipine [3], pharmaceutical compositions stabilizer, and in the preparation of aluminum-
La implicación del colectivo femenino en los cultos indígenas y latinos del "Conventus Bracaraugustanus" (2002)

Las fuentes escritas (literarias y epigráficas) nos informan sobre el comportamiento de la población hispano-romana. Basándose en ellas, trataremos de acercarnos al modo de vida del colectivo femenino en el Conventus Bracaraugustanus durante el período romano. Abstract: The written sources (literary and epigraphy) inform us about the Hispanic-roman population's behaviour, basing on them, we will try to get close to the feminine colective way of behaving in the Conventus Bracaraugustanus, during the Roman period.
Development of a Low-Resource RNA Extraction Cassette Based on Surface Tension Valves (2011)

Nucleic acid-based diagnostics are highly sensitive and specific, but are easily disrupted by the presence of interferents in biological samples. In a laboratory or hospital setting, the influence of these interferents can be minimized using an RNA or DNA extraction procedure prior to analysis. However, in low-resource settings, limited access to specialized instrumentation and trained personnel presents challenges that impede sample preparation. We have developed a self-contained nucleic acid extraction cassette suitable for operation in a low-resource setting. This simple design contains processing solutions preloaded within a continuous length of 1.6 mm inner diameter Tygon tubing. Processing solutions are separated by air gaps and held in place during processing by the surface tension forces at the liquid-air interface, viz. surface tension valves. Nucleic acids preferentially adsorbed to silica-coated magnetic particles are separated from sample interferents using an external magnet to transfer the nucleic acid biomarker through successive solutions to precipitate, wash and elute in the final cassette solution. The efficiency of the extraction cassette was evaluated using quantitative reverse transcriptase PCR (qRT-PCR) following extraction of respiratory syncytial virus (RSV) RNA. RNA was recovered from TE buffer or from lysates of RSV infected HEp-2 cells with 55 and 33% efficiency, respectively, of the Qiagen RNeasy kit. Recovery of RSV RNA from RSV infected HEp-2 cells was similar at 30% of the RNeasy kit. An overall limit of detection after extraction was determined to be nearly identical (97.5%) to a laboratory-based commercially available kit. These results indicate that this extraction cassette design has the potential to be an effective sample preparation device suitable for use in a low-resource setting.
A New Mechanism for Mesoscale Legged Locomotion in Compliant Tubular Environments (2009)

We present design and experimental performance results for a novel mechanism for robotic legged locomotion at the mesoscale (from hundreds of microns to tens of centimeters). The new mechanism is compact and strikes a balance between conflicting design objectives, exhibiting high foot forces and low power consumption. It enables a small robot to traverse a compliant, slippery, tubular environment, even while climbing against gravity. This mechanism is useful for many mesoscale locomotion tasks, including endoscopic capsule robot locomotion in the gastrointestinal tract. It has enabled fabrication of the first legged endoscopic capsule robot whose mechanical components match the dimensions of commercial pill cameras (11 mm diameter by 25 mm long). A novel slot-follower mechanism driven via lead screw enables the mechanical components of the capsule robot to be as small while simultaneously generating 0.63 N average propulsive force at each leg tip. In this paper, we describe kinematic and static analyses of the lead screw and slot-follower mechanisms, optimization of design parameters, and experimental design and tuning of a gait suitable for locomotion. A series of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ex vivo</i> experiments demonstrate capsule performance and ability to traverse the intestine in a manner suitable for inspection of the colon in a time period equivalent to standard colonoscopy.
A Femtomolar Acting Octapeptide Interacts with Tubulin and Protects Astrocytes against Zinc Intoxication (2004)

An octapeptide was previously described that protects neurons against a wide variety of insults directly and indirectly as a result of interactions (at femtomolar concentrations) with supporting glial cells. The current study set out to identify the octapeptide binding molecules so as to understand the high affinity mechanisms of cellular protection. Studies utilizing affinity chromatography of brain extracts identified tubulin, the brain major protein, as the octapeptide-binding ligand. Dot blot analysis with pure tubulin and the biotinylated octapeptide verified this finding. When added to cerebral cortical astrocytes, the octapeptide (10(-15)-10(-10) m) induced a rapid microtubule reorganization into distinct microtubular structures that were stained by monoclonal tubulin antibodies and visualized by confocal microscopy. Fluorescein-labeled octapeptide induced a similar change and was detected in the intracellular milieu, even when cells were incubated at 4 degrees C or at low pH. In a cell-free system, the octapeptide stimulated tubulin assembly into microtubules. Furthermore, treatment of astrocytes with zinc chloride resulted in microtubule disassembly and cell death that was protected by the octapeptide. In conclusion, the results suggest that the octapeptide crosses the plasma membrane and interacts directly with tubulin, the microtubule subunit, to induce microtubule reorganization and improved survival. Because microtubules are the key component of the neuronal and glial cytoskeleton that regulates cell division, differentiation, and protection, this finding may explain the breadth and efficiency of the cellular protective capacities of the octapeptide.
The role of complement in pregnancy-induced hypertensive disease (1993)

Preeclampsia is a pregnancy-induced hypertensive disease with an incidence of about 5% in primigravidas and, being common, it significantly contributes to maternal and neonatal morbidity and mortality. The primary cause remains unknown but might be immunologic, since immunologic aberrations are described in preeclampsia. Activation of the complement system in pregnancy-induced hypertensive disease has been discussed during the last 60 years. It is now strongly indicated that complement activation occurs in preeclampsia. The complement system is very potent and one of the major effector pathways of the process of inflammation. The pathological manifestations, endothelial damage and microvascular injury, and thereby the clinical findings in preeclampsia, may be explained by complement activation, resulting in the direct vascular effects of biological active complement components and complement-mediated activation of leukocytes, with release of potent inflammatory mediators. This new etiological hypothesis might give other options in therapy and prevention of pregnancy-induced hypertensive disease.
Calcium-dependent Clustering of Inositol 1,4,5-Trisphosphate Receptors (1998)

Rat basophilic leukemia (RBL-2H3) cells predominantly express the type II receptor for inositol 1,4,5-trisphosphate (InsP3), which operates as an InsP3-gated calcium channel. In these cells, cross-linking the high-affinity immunoglobulin E receptor (FcepsilonR1) leads to activation of phospholipase C gamma isoforms via tyrosine kinase- and phosphatidylinositol 3-kinase-dependent pathways, release of InsP3-sensitive intracellular Ca2+ stores, and a sustained phase of Ca2+ influx. These events are accompanied by a redistribution of type II InsP3 receptors within the endoplasmic reticulum and nuclear envelope, from a diffuse pattern with a few small aggregates in resting cells to large isolated clusters after antigen stimulation. Redistribution of type II InsP3 receptors is also seen after treatment of RBL-2H3 cells with ionomycin or thapsigargin. InsP3 receptor clustering occurs within 5-10 min of stimulus and persists for up to 1 h in the presence of antigen. Receptor clustering is independent of endoplasmic reticulum vesiculation, which occurs only at ionomycin concentrations >1 microM, and maximal clustering responses are dependent on the presence of extracellular calcium. InsP3 receptor aggregation may be a characteristic cellular response to Ca2+-mobilizing ligands, because similar results are seen after activation of phospholipase C-linked G-protein-coupled receptors; cholecystokinin causes type II receptor redistribution in rat pancreatoma AR4-2J cells, and carbachol causes type III receptor redistribution in muscarinic receptor-expressing hamster lung fibroblast E36(M3R) cells. Stimulation of these three cell types leads to a reduction in InsP3 receptor levels only in AR4-2J cells, indicating that receptor clustering does not correlate with receptor down-regulation. The calcium-dependent aggregation of InsP3 receptors may contribute to the previously observed changes in affinity for InsP3 in the presence of elevated Ca2+ and/or may establish discrete regions within refilled stores with varying capacity to release Ca2+ when a subsequent stimulus results in production of InsP3.
A Growth Strategy for Start‐up Businesses (1988)

The most successful start‐up businesses are those whose founders integrate their personal goals into the strategy and ongoing operations of the company.
Treatment and Prophylaxis of Manic Stateswith a Carbonic Anhydrase Inhibitor (1970)

Considering the similarity of the change in electrolyte distribution after the administration of lithium preparations and of carbonic anhydrase inhibitors, we have made an attempt of the treatment and prophylaxis of manic states with benzanilamide, a carbonic anhydrase inhibitor. The following conclusions are tentatively drawn: (1) Benzanilamide, at the oral dosage of 1,000-2,000 mg/day, may have anti-manic effects, though the potency seems to be somewhat weaker than that of lithium preparation. (2) Benzanilamide may well prevent from the manic episodes in a patient exhibiting frequent relapses. (3) Benzanilamide may be superior than lithium preparation in the prophylactic use to recurrent mania, since the former develops much less adverse reactions and can be used more safely than the latter.
Cerebral Radiation Necrosis (2003)

Radiation necrosis is a very significant complication of radiation treatment of brain cancers and may have a tremendous impact on a patient's quality of life. The early diagnosis of radiation necrosis in patients receiving radiation therapy to the brain has improved with current neuro-imaging modalities and better understanding of its pathophysiology. The development of treatment modalities has been slower, but is nonetheless promising.
Integrating Forward Osmosis into Microbial Fuel Cells for Wastewater Treatment, Water Extraction and Bioelectricity Generation (2011)

A novel osmotic microbial fuel cell (OsMFC) was developed by using a forward osmosis (FO) membrane as a separator. The performance of the OsMFC was examined with either NaCl solution or artificial seawater as a catholyte (draw solution). A conventional MFC with a cation exchange membrane was also operated in parallel for comparison. It was found that the OsMFC produced more electricity than the MFC in both batch operation (NaCl solution) and continuous operation (seawater), likely due to better proton transport with water flux through the FO membrane. Water flux from the anode into the cathode was clearly observed with the OsMFC but not in the MFC. The solute concentration of the catholyte affected both electricity generation and water flux. These results provide a proof of concept that an OsMFC can simultaneously accomplish wastewater treatment, water extraction (from the wastewater), and electricity generation. The potential applications of the OsMFC are proposed for either water reuse (linking to reverse osmosis for reconcentration of draw solution) or seawater desalination (connecting with microbial desalination cells for further wastewater treatment and desalination).
Dynamic Properties of Salt-Free Viscoelastic Micellar Solutions (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamic Properties of Salt-Free Viscoelastic Micellar SolutionsF. Kern, F. Lequeux, R. Zana, and S. J. CandauCite this: Langmuir 1994, 10, 6, 1714–1723Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/la00018a018https://doi.org/10.1021/la00018a018research-articleACS PublicationsRequest reuse permissionsArticle Views1208Altmetric-Citations329LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simulation of QRST Integral Maps With a Membrane-Based Computer Heart Model Employing Parallel Processing (2004)

The simulation of the propagation of electrical activity in a membrane-based realistic-geometry computer model of the ventricles of the human heart, using the governing monodomain reaction-diffusion equation, is described. Each model point is represented by the phase 1 Luo-Rudy membrane model, modified to represent human action potentials. A separate longer duration action potential was used for the M cells found in the ventricular midwall. Cardiac fiber rotation across the ventricular wall was implemented via an analytic equation, resulting in a spatially varying anisotropic conductivity tensor and, consequently, anisotropic propagation. Since the model comprises approximately 12.5 million points, parallel processing on a multiprocessor computer was used to cut down on simulation time. The simulation of normal activation as well as that of ectopic beats is described. The hypothesis that in situ electrotonic coupling in the myocardium can diminish the gradients of action-potential duration across the ventricular wall was also verified in the model simulations. Finally, the sensitivity of QRST integral maps to local alterations in action-potential duration was investigated.
Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus (2007)

Recurrent outbreaks of highly pathogenic avian influenza virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe and effective vaccines. Influenza virus-like particles (VLPs) have been suggested to be a promising vaccine approach. However, VLP-induced immune responses, and their roles in inducing memory immune responses and cross-protective immunity have not been investigated. In this study, we developed VLPs containing influenza virus A/PR8/34 (H1N1) hemagglutinin (HA) and matrix (M1) proteins and investigated their immunogenicity, long-term cross-protective efficacy, and effects on lung proinflammatory cytokines in mice. Intranasal immunization with VLPs containing HA induced high serum and mucosal antibody titers and neutralizing activity against PR8 and A/WSN/33 (H1N1) viruses. Mice immunized with VLPs containing HA showed little or no proinflammatory lung cytokines and were protected from a lethal challenge with mouse-adapted PR8 or WSN viruses even 5 months postimmunization. Influenza VLPs induced mucosal immunoglobulin G and cellular immune responses, which were reactivated rapidly upon virus challenge. Long-lived antibody-secreting cells were detected in the bone marrow of immunized mice. Immune sera administered intranasally were able to confer 100% protection from a lethal challenge with PR8 or WSN, which provides further evidence that anti-HA antibodies are primarily responsible for preventing infection. Taken together, these results indicate that nonreplicating influenza VLPs represent a promising strategy for the development of a safe and effective vaccine to control the spread of lethal influenza viruses.
Expression of Ki-67, cyclin D1 and apoptosis markers correlated with survival in prostate cancer patients treated by radical prostatectomy. (2007)

The expression of Ki-67, cyclin D1 and a high apoptotic rate are related to a malignant phenotype in prostate cancer, but their prognostic value is inferior to standard histological prognostic factors.
Contralateral Smile and Laughter, but No Mirth, Induced by Electrical Stimulation of the Cingulate Cortex (2006)

The cerebral representation of laughter is dissociated. The emotional aspects seem to be processed in the temporal lobe; whereas the motor features apparently rely on the frontal cortex. In a few prior studies of patients in whom laughter was elicited by electrical stimulation (ES), it always was associated with mirth. We report a patient in whom ES in the right cingulate gyrus elicited smile and laughter, but no mirth. At low voltages, smiling was seen first contralaterally and became bilateral with increasing currents. Our observation supports the concept of the motor representation of laughter in the mesial frontal cortex.