gebhart/patrepeval huggingface dataset:
Automated texture registration and stitching for real world models (2002)

A system is presented which automatically registers and stitches textures acquired from multiple photographic images onto the surface of a given corresponding 3D model. Within this process the camera position, direction and field of view must be determined for each of the images. For this registration, which aligns a 2D image to a 3D model we present an efficient hardware-accelerated silhouette-based algorithm working on different image resolutions that accurately registers each image without any user interaction. Besides the silhouettes, the given texture information can be used to improve accuracy by comparing one stitched texture to already registered images resulting in a global multi-view optimization. After the 3D-2D registration for each part of the 3D model's surface the view is determined which provides the best available texture. Textures are blended at the borders of regions assigned to different views.
A Protein That Inhibits Surfactant in Respiratory Distress Syndrome (1986)

A protein that interferes with surfactant function is present in the airways and alveoli of infants with respiratory distress syndrome (RDS). This inhibitor is also found in serum and amniotic fluid and presumably appears in the alveoli because of the abnormal protein leak present in the lungs of infants with RDS. This protein has a molecular weight of about 110,000 and is resistant to boiling or lipid extraction. As measured by radioimmunoassay, the ratio of inhibitor to phosphatidylcholine decreased from 8.1 +/- 2.3 early in the course of RDS to 0.7 +/- 0.1 on the day of extubation. The value at extubation was the same as that measured for preterm infants without RDS. The inhibitor to phosphatidylcholine ratio in airway samples from infants with RDS correlated significantly with simultaneously recorded pO2/FiO2 ratios and the peak inspiratory pressures used to normalized pCO2 values. These results are consistent with the concept that the inhibitor contributes to surfactant dysfunction and thus the respiratory failure characteristic of RDS.
Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type (1996)

We analysed the clinical significance of ANCA in patients with ulcerative colitis. On either an indirect immunofluorescence assay or an ELISA with fixed neutrophils, 71% (25/35) of the patients were positive for ANCA. However, only half of them reacted with either cathepsin G or lactoferrin. Western blot assays revealed positive bands in 40% (10/25) of the antibody-positive patients. The sizes of the bands detected were approximately 58, 47, 44, 40, and 28 kD. No significant correlation was found between the ANCA positivity and various variables, i.e. disease activity, extent of lesion, or treatment of the disease. The anti-cathepsin G and 28-kD positivity, however, significantly correlated with a refractory type of ulcerative colitis.
On the Performance of Certificate Validation Schemes Based on Pre-Computed Responses (2007)

In public key infrastructures (PKIs), cryptographically protected responses are used to validate the status of certificates. The online certificate status protocol (OCSP) [1] is a scheme that was proposed for this purpose. However, OCSP is expensive primarily because it requires online trusted servers. Currently, there exists cheaper online validation schemes wherein validating clients download pre-computed responses from untrusted distribution servers. Examples of such schemes include NOVOMODO [3], certificate revocation tree (CRT) [4], authenticated dictionary (AD) [5] and the recently proposed augmented certificate revocation lists (ACRL) [6]. In this paper, we conduct a detailed performance analysis of these schemes with respect to their computational, network and storage costs and compare them against OCSP. Based on the system model that we adopt, our results show that all these schemes perform better than OCSP.
An Accurate Eye Center Localization Method for Low Resolution Color Imagery (2012)

The development of eye localization and gaze tracking systems without the constraint of dedicated hardware, has lately motivated the scientific community. A lot of "passive" methods have been proposed, however their precision is limited and significantly reduced compared to the commercial, hardware-based, eye tracking devices. In this paper we introduce an automatic, non-intrusive method for precise eye center localization in low resolution images. To this end, the proposed system utilizes radial symmetry transform in both the original eye image and a novel eye map image derived from color information. Experimental results demonstrate great accuracy and robustness even in challenging cases, achieving also significant improvement over existing methods.
DNA-templated nanofabrication (2008)

Nanofabrication, or the organizational control over matter at the nanometre scale, is an intriguing scientific challenge requiring multidisciplinary tools for its solution. DNA is a biomolecule that can be combined with other nanometre-scale entities through chemical self-assembly to form a broad variety of nanomaterials. In this tutorial review we present the principles that allow DNA to interact with other chemical species, and describe the challenges and potential applications of DNA as a template for making both biological and inorganic features with nanometre resolution. As such, this report should be of interest to chemists, surface and materials scientists, biologists, and nanotechnologists, as well as others who seek to use DNA in nanofabrication.
Patterns of Inflammation in Prostatic Hyperplasia: A Histologic and Bacteriologic Study (1979)

In a series of 162 cases of surgically resected hyperplastic prostates the incidence of inflammation is 98.1%. Six morphologic patterns of inflammation are described: 1) segregated glandular inflammation, 2) periglandular inflammation, 3) diffuse stromal inflammation, 4) isolated stromal lymphoid nodules, 5) acute necrotizing inflammation and 6) focal granulomatous inflammation. The most common pattern, segregated glandular inflammation, is characterized by intraluminal neutrophils and foamy macrophages and by chronic inflammatory cells in the surrounding stroma. No significant morphological differences are found among groups of cases with positive and negative evidence by culture of bacterial prostatic infection. Quantitative but not qualitative morphologic differences are found between cases of gram-negative infections and infection by gram-positive organisms that often are considered non-pathogens.
Selective Inhibition of Leukemia Cell Proliferation by BCR-ABL Antisense Oligodeoxynucleotides (1991)

To determine the role of the BCR-ABL gene in the proliferation of blast cells of patients with chronic myelogenous leukemia, leukemia blast cells were exposed to synthetic 18-mer oligodeoxynucleotides complementary to two identified BCR-ABL junctions. Leukemia colony formation was suppressed, whereas granulocyte-macrophage colony formation from normal marrow progenitors was unaffected. When equal proportions of normal marrow progenitors and blast cells were mixed, exposed to the oligodeoxynucleotides, and assayed for residual colony formation, the majority of residual cells were normal. These findings demonstrate the requirement for a functional BCR-ABL gene in maintaining the leukemic phenotype and the feasibility of gene-targeted selective killing of neoplastic cells.
Interstitial Collagen Synthesis and Processing in Human Amnion: A Property of the Mesenchymal Cells1 (1996)

This study was conducted to evaluate the ontogeny and cellular site of interstitial collagen formation in amnion, the tissue that provides the tensile strength of the human fetal membranes. The levels of procollagen alpha 1(I), alpha 2(I), and alpha 1(III) subunit mRNAs and the specific activities of the enzymes prolyl 4-hydroxylase and lysyl hydroxylase were greatest in human amnion tissue early in gestation, decreasing rather abruptly after 12-14 wk gestation to a nadir that persisted to term. To evaluate these findings further, amnion epithelial and mesenchymal cells were separated by differential proteinase treatment. The freshly separated cells as well as epithelial and mesenchymal cells maintained in culture were evaluated to assess the cellular site of interstitial collagen synthesis. By Northern analysis of total RNA, large amounts of procollagens alpha 1(I), alpha 2(I), and alpha 1(III) mRNAs were found in mesenchymal cells (freshly separated and in culture), but only negligible amounts of these transcripts were detected in RNA of freshly separated or cultured epithelial cells. The level of prolyl 4-hydroxylase alpha-subunit mRNA in mesenchymal cells was somewhat greater than that in epithelial cells. Radiolabeled collagen I synthesis from [3H]proline and [3H]glycine was not detected in amnion epithelial cells, whereas [3H]collagen alpha 1(I) and alpha 2(I) subunits were synthesized in large amounts by mesenchymal cells. A very small amount of [3H]collagen alpha 1(III) was synthesized in epithelial cells, but large amounts were formed in mesenchymal cells. These findings indicate that the mesenchymal cells are the site of interstitial collagen synthesis and processing in amnion. The density of mesenchymal cells in human amnion declines after the first trimester of pregnancy, and a significant decline in DNA content per unit of amnion tissue dry weight as pregnancy progressed was demonstrated in this study. Since the epithelial cells form an uninterrupted epithelium throughout gestation, the decline in DNA content probably corresponds to the decrease in the density of mesenchymal cells that commences after the first trimester pregnancy. Thus, the increase in the ratio of epithelial to mesenchymal cells as a function of gestational age may explain, at least in part, the decline in the levels of collagen mRNAs and the specific activities of lysyl and prolyl 4-hydroxylase in amnion tissue during human pregnancy.
Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. (1981)

Patterns of bone loss in the axial and the appendicular skeleton were studied in 185 normal volunteers (105 women and 82 men; age range, 20--89 yr) and in 76 women and 9 men with vertebral fractures due to osteoporosis. Bone mineral density was measured in vivo at the lumbar spine (predominantly trabecular bone) by dual photon absorptiometry and at the midradius (greater than 95% cortical bone) and distal radius (75% cortical and 25% trabecular bone) by single photon absorptiometry. In normal women, bone diminution from the vertebrae began in young adulthood and was linear. In the appendicular skeleton, bone diminution did not occur until age 50 yr, was accelerated from aged 51 to 65 yr, and then decelerated somewhat after age 65 yr. Overall bone diminution throughout life was 47% for the vertebrae, 30% for the midradius, and 39% for the distal radius. In normal men, vertebral and appendicular bone diminution with aging was minimal or insignificant. Mean bone mineral density was lower in patients with osteoporosis than in age- and sex-matched normal subjects at all three scanning sites, although spinal measurements discriminated best; however, there was considerable overlap. By age 65 yr, half of the normal women (and by age 85 yr, virtually all of them) had vertebral bone mineral density values below the 90th percentile of women with vertebral fractures and, thus, might be considered to have asymptomatic osteoporosis. For men, the degree of overlap was less. The data suggest that disproportionate loss of trabecular bone from the axial skeleton is a distinguishing characteristic of spinal osteoporosis.
Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme (2010)

5-Aza-2'-deoxycytidine (5-aza-dC) is a nucleoside analogue with cytotoxic and DNA demethylating effects. Here we show that 5-aza-dC induces the proteasomal degradation of free (non-chromatin bound) DNMT1 through a mechanism which is dependent on DNA synthesis and the targeting of incorporated 5-aza-dC residues by DNMT1 itself. Thus, 5-aza-dC induces Dnmt1 degradation in wild-type mouse ES cells, but not in Dnmt [3a(-/-), 3b(-/-)] mouse ES cells which express Dnmt1 but lack DNA methylation (<0.7% of CpG methylated) and contain few hemi-methylated CpG sites, these being the preferred substrates for Dnmt1. We suggest that adducts formed between DNMT1 and 5-aza-dC molecules in DNA induce a ubiquitin-E3 ligase activity which preferentially targets free DNMT1 molecules for degradation by the proteasome. The proteasome inhibitor MG132 prevents DNMT1 degradation and reduces hypomethylation induced by 5-aza-dC.
Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons (2005)

Nerve growth factor (NGF) has been shown to promote survival and function of cholinergic neurons in the basal forebrain in various models of neuronal degeneration in rodents and primates. We examined whether a regulatable in vivo expression system can control the survival of cholinergic neurons after injury, using a tetracycline-regulated promoter (“tet-off” system) to modulate lentiviral NGF gene delivery. Two weeks after lesions to cholinergic neurons, significant cell rescue (65 ± 8% neuron survival; P < 0.005 compared to controls) was observed when NGF expression was activated. Treatment with the tetracycline analog doxycycline to turn gene expression “off” resulted in a significant loss of cholinergic neurons (only 37 ± 5% neurons remained, an amount that did not differ from untreated, lesioned controls). Animals treated with a constitutively active and robust nonregulated NGF expression system showed the same degree of neuronal rescue (73 ± 8%) as animals treated with activated tet-regulated vectors. ELISA measurements confirmed that oral treatment of animals with doxycycline reduced NGF protein levels to levels in untreated control subjects. These data demonstrate for the first time that NGF delivery by lentiviral gene transfer using tetracycline-regulated promoters can completely regulate neuronal rescue and protein production in the brain.
The effect of casein phosphopeptide‐amorphous calcium phosphate on remineralization of artificial caries‐like lesions: an in vitro study (2008)

Based on the data obtained, CPP-ACP containing Tooth Mousse remineralized initial enamel lesions and it showed a higher remineralizing potential when applied as a topical coating after the use of a fluoridated toothpaste.
Prodrug Strategies Based on Intramolecular Cyclization Reactions (1997)

Several new prodrug systems for amines, alcohols, and peptides are reviewed. The design of these new prodrug systems takes advantage of several facile intramolecular cyclization reactions, that permit separate manipulation of the release kinetics independent of the structural features of the drug moiety. Such systems can be used for the preparation of esterase-, phosphatase-, and redox-sensitive prodrugs of amines and alcohols and esterase-sensitive cyclic prodrugs of peptides and peptide mimetics.
Surface antigenic determinants on human pluripotent and unipotent hematopoietic progenitor cells (1983)

RFB-1 is a monoclonal antibody previously shown to react with granulocyte-monocyte progenitors (CFU-GM) and immature lymphoid cells in human bone marrow. RFB-HLA-DR is a monoclonal antibody that reacts with HLA-DR (la-like) antigens. The present study shows that the bone marrow subset reactive with both RFB-1 and RFB-HLA-DR contains all the cells that give rise to mixed hematopoietic colonies (derived from CFU- GEMM; a pluripotent human progenitor cell) as well as to megakaryocytic (megakaryocyte-CFU-derived) and erythropoietic (derived from erythroid burst-forming units, BFU-E) colonies, as shown by fluorescence- activated cell sorting and complement-mediated cytotoxicity. These results indicate that CFU-GEMM, BFU-E, and megakaryocyte-CFU express RFB-1 and la-like antigens. RFB-1 antigen is also expressed on erythroid colony-forming units (CFU-E). RFB-1 and RFB-HLA-DR are useful reagents in the study of hematopoietic stem cells.
Behavioral Modeling and Linearization of RF Power Amplifiers (2014)

Wireless voice and data communications have made great improvements, with connectivity now virtually ubiquitous. Users are demanding essentially perfect transmission and reception of voice and data. The infrastructure that supports this wide connectivity and nearly error-free delivery of information is complex, costly, and continually being improved. This resource describes the mathematical methods and practical implementations of linearization techniques for RF power amplifiers for mobile communications. This includes a review of RF power amplifier design for high efficiency operation. Readers are also provided with mathematical approaches to modeling nonlinear dynamical systems, which can be applied in the context of modeling the PA for identification in a pre-distortion system. This book also describes typical approaches to linearization and digital pre-distortion that are used in practice.
Naphthyridines. Structure, physicochemical properties and general methods of synthesis (2000)

Data on the synthesis, chemical properties and applications of naphthyridines published mainly over the last 15 years are described systematically and analysed. The bibliography includes 238 references.
The Microsoft Repository (1997)

The Microsoft Repository is an object-oriented repository that ships as a component of Visual Basic (Version 5.0). It includes a set of ActiveX interfaces that a developer can use to define information models, and a repository engine that is the underlying storage mechanism for these information models. The repository engine sits on top of a SQL database system. The repository is designed to meet the persistent storage needs of software tools. Its two main technical goals are: . compatibility with Microsoft&amp;apos;s existing ActiveX object architecture consisting of the Component Object Model (COM) and Automation and . extensibility by customers and independent software vendors who need to tailor the repository by adding functionality to objects stored by the repository engine and extending information models provided by Microsoft and others. This paper explains how the Repository attains these goals by providing an object-oriented database (OODB) architecture based on Microsoft&amp;apos;s binary ob...
Risk Factors for Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study (2003)

The development of MCI is associated with measurements of cognition and depression, racial and constitutional factors, and cerebrovascular disease. Early cognitive deficits seem to be a common denominator for the 2 forms of MCI; the presence of cerebrovascular disease and the APOE epsilon4 allele is associated with the amnestic type of MCI.
Hydrothermal synthesis and crystal structure of a new three-dimensional aluminum-organic framework MIL-69 with 2,6-naphthalenedicarboxylate (ndc), Al(OH)(ndc)·H2O (2005)

A new three-dimensional aluminum-organic framework, MIL-69 or Al(OH)(O 2 C–C 10 H 6 –CO 2 )·H 2 O, has been hydrothermally synthesized at 210 °C for 16 h, by using 2,6-naphthalenedicarboxylic acid as a rigid ligand. The model for the crystal structure of MIL-69 was determined by means of lattice energy minimizations and further refined against the powder XRD data using the Rietveld refinement method. The crystal structure consists of infinite chains of AlO 4 (OH) 2 octahedra corner-linked through the μ 2 -hydroxyl groups and connected by the 2,6-naphthalenedicarboxylate moieties. It results in the formation of flat channels parallel to the chains of aluminum octahedra, running along the c axis. A water molecule is trapped nearby the center of the tunnels and mainly interacts via hydrogen bonds with the hydroxyl groups and the oxygen atoms of the carboxylates. Although the three-dimensional aluminum-organic framework is stable up to 450 °C, the tunnels still remain shrunk upon removal of water molecule, because of the occurrence π–π interactions between the naphthalene groups. The MIL-69 phase was characterized by solid state NMR MAS 27 Al, 1 H and 13 C{ 1 H-decoupled}, which is consistent with the crystal structure description. Crystal data. – MIL-69, Al(OH)(O 2 C–C 10 H 6 –CO 2 )·H 2 O: Mr = 267.11 g mol –1 , monoclinic, space group C 2/ c (no. 15), a = 24.598(2) Å, b = 7.5305(6) Å, c = 6.5472(5) Å, β = 106.863(8)°, V = 1160.6(2) Å 3 , Z = 4.
Gonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer (2005)

In 1979, the first prostate cancer patient was treated with a GnRH agonist at the Laval University Medical Center in Quebec City, Canada, thus rapidly leading to the worldwide replacement of surgical castration and high doses of estrogens. The discovery of medical castration with GnRH agonists was soon followed by fundamental changes in the endocrine therapy of prostate cancer. Most importantly, the excellent tolerance accompanying the treatment with GnRH agonists has been a key factor that permitted a series of studies demonstrating a major reduction in the death rate from prostate cancer ranging from 31 to 87% at 5 yr of follow-up in patients with localized or locally advanced prostate cancer. In fact, a one third reduction in prostate cancer deaths has been calculated in the metaanalysis of all available studies. The general acceptance of this discovery by patients and physicians is illustrated by world sales above 3.0 billion U.S. dollars in 2003. Although extremely efficient in achieving complete medical castration and well tolerated, with no other side effects than the expected hypoandrogenicity, GnRH agonists should not be administered alone. In fact, shortly after discovery of the castration effects of GnRH agonists, we observed that approximately 50% of androgens remain in the prostate after castration, thus leading to the recognition of the role of adrenal dehydroepiandrosterone as an important source of the androgens synthesized locally in the prostate and in many peripheral target tissues. We therefore developed combined androgen blockade (CAB), whereby the androgens of both testicular and adrenal origins are blocked simultaneously at start of treatment with the combination of a GnRH agonist to block the testis and a pure antiandrogen to block the action of the androgens produced locally. CAB, first used in advanced metastatic disease, has been the first treatment shown to prolong life in prostate cancer. Most interestingly, in 2002, we made the observation that CAB alone given continuously for 6.5 yr or more leads to cure of the disease in at least 90% of cases, thus suggesting that androgen blockade combining a GnRH agonist and a pure antiandrogen could well be the most efficient treatment of localized prostate cancer, and thus offering the possibility of practically eliminating death from prostate cancer.