gebhart/patrepeval huggingface dataset:
Semantic-Based Location Recommendation With Multimodal Venue Semantics (2014)

In recent years, we have witnessed a flourishing of location -based social networks. A well-formed representation of location knowledge is desired to cater to the need of location sensing, browsing, navigation and querying. In this paper, we aim to study the semantics of point-of-interest (POI) by exploiting the abundant heterogeneous user generated content (UGC) from different social networks. Our idea is to explore the text descriptions, photos, user check-in patterns, and venue context for location semantic similarity measurement. We argue that the venue semantics play an important role in user check-in behavior. Based on this argument, a unified POI recommendation algorithm is proposed by incorporating venue semantics as a regularizer. In addition to deriving user preference based on user-venue check-in information, we place special emphasis on location semantic similarity. Finally, we conduct a comprehensive performance evaluation of location semantic similarity and location recommendation over a real world dataset collected from Foursquare and Instagram. Experimental results show that the UGC information can well characterize the venue semantics, which help to improve the recommendation performance.
A scheme for robust distributed sensor fusion based on average consensus (2005)

We consider a network of distributed sensors, where where each sensor takes a linear measurement of some unknown parameters, corrupted by independent Gaussian noises. We propose a simple distributed iterative scheme, based on distributed average consensus in the network, to compute the maximum-likelihood estimate of the parameters. This scheme doesn't involve explicit point-to-point message passing or routing; instead, it diffuses information across the network by updating each node's data with a weighted average of its neighbors' data (they maintain the same data structure). At each step, every node can compute a local weighted least-squares estimate, which converges to the global maximum-likelihood solution. This scheme is robust to unreliable communication links. We show that it works in a network with dynamically changing topology, provided that the infinitely occurring communication graphs are jointly connected.
The respective roles of the protein kinase and pppA2′ p5′ A2′ p5′ A-activated endonuclease in the inhibition of protein synthesis by double stranded RNA in rabbit reticulocyte lysates (1979)

Double-stranded RNA (dsRNA) inhibits protein synthesis in rabbit reticulocyte lysates by activating the synthesis of the endonuclease effector pppA2' p5' A2' p5' A(2-5A) and a protein kinase which phosphorylates the protein synthesis initiation factor eIF-2. Under certain assay conditions, high concentrations of dsRNA are without inhibitory effect in many lysates (high dsRNA "reversible" lysates). In these lysates natural dsRNA at low concentrations stimulated protein kinase activity to a greater extent than did the synthetic dsRNA poly rI.rC. Synthesis of 2--5A was greater when poly rI.rC was used. However, a number of factors, including the salt concentration and messenger RNA used, combine to determine the overall effect of dsRNA on protein synthesis under any given set of experimental conditions.
Generating Customer Loyalty in an Emerging Competitive Market: a Banking Industry Study (2012)

Existing streams of literature are integrated to propose a conceptual framework that highlights the impact of relationship marketing on customer loyalty and its outcomes. The framework aims to provide insights into the underpinnings of relationship marketing. Using empirical research, the study identifies three elements of relationship marketing like trust, commitment and conflict-handling as the antecedents of customer loyalty. Significant outcomes of customer loyalty are also identified. The findings of this study have important implications for firms aiming to build customer loyalty and retention. From a managerial perspective, this study sheds some light on the elements of relationships and outcomes that may be identified as critical for firms in a competitive environment.
Grid Generation for Fluid Mechanics Computations (1985)

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from experiments, field measurements, and large-scale simulations at multiple spatiotemporal scales. Machine learning (ML) offers a wealth of techniques to extract ...Read More
Composite Dielectrics and Surfactants for Low Voltage Electrowetting Devices (2008)

In this work electrowetting operation at <12 V has been achieved through implementation of composite dielectrics and surfactants. The composite dielectrics consist of A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> covered by a thin film of hydrophobic Cytop fluoropolymer. These composite dielectrics exhibit higher capacitance and therefore lower voltage electrowetting operation. Atomic layer deposition of A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> and plasma-enhanced chemical vapor deposition of Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> were chosen because they can be deposited at low temperature, are pin-hole free, and because they can be conformably coated on 3D surfaces. Surfactants were also explored to lower the water/oil interfacial surface tension and thereby further reduce the voltages required for electrowetting. These results are important for continued development of arrayed electrowetting optics for displays and beam steering applications.
Location of procollagen in chick corneal and tendon fibroblasts with ferritin-conjugated antibodies. (1975)

Three distinct antiprocollagen preparations were characterized and used in immunocytochemical staining of chick embryo corneal and tendon cells. The several ferritin-conjugated antibody preparations permitted similar location of procollagen in the cisternae of the rough endoplasmic reticulum and in Golgi elements in both cell types. The ability to demonstrate and interpret specific ferritin staining was dependent on the extent of membrane breakage in each of those organelles, coupled with adequate retention of cell morphology. Corneal fibroblasts appeared to suffer more extensive intracellular membrane damage under controlled conditions of homogenization than tendon fibroblasts, facilitating the identification of procollagen in Golgi vacuoles of these cells. None of the labeled material appeared to by cytoplasmic in origin since ferritin was observed in the cytoplasm only in the vicinity of Golgi elements that were extensively broken. This study extends previous immunological evidence for the presence of procollagen in the Golgi complex and calls attention to the problems to be encountered in locating the antigen in small Golgi vesicles and lamellae.
RecombinantSaccharomyces cerevisiaeExpressing P450 in Artificial Digestive Systems: a Model for Biodetoxication in the Human Digestive Environment (2003)

The use of genetically engineered microorganisms such as bacteria or yeasts as live vehicles to carry out bioconversion directly in the digestive environment is an important challenge for the development of innovative biodrugs. A system that mimics the human gastrointestinal tract was combined with a computer simulation to evaluate the survival rate and cinnamate 4-hydroxylase activity of a recombinant model of Saccharomyces cerevisiae expressing the plant P450 73A1. The yeasts showed a high level of resistance to gastric and small intestinal secretions (survival rate after 4 h of digestion, 95.6% +/- 10.1% [n = 4]) but were more sensitive to the colonic conditions (survival rate after 4 h of incubation, 35.9% +/- 2.7% [n = 3]). For the first time, the ability of recombinant S. cerevisiae to carry out a bioconversion reaction has been demonstrated throughout the gastrointestinal tract. In the gastric-small intestinal system, 41.0% +/- 5.8% (n = 3) of the ingested trans-cinnamic acid was converted into p-coumaric acid after 4 h of digestion, as well as 8.9% +/- 1.6% (n = 3) in the stomach, 13.8% +/- 3.3% (n = 3) in the duodenum, 11.8% +/- 3.4% (n = 3) in the jejunum, and 6.5% +/- 1.0% (n = 3) in the ileum. In the large intestinal system, cinnamate 4-hydroxylase activity was detected but was too weak to be quantified. These results suggest that S. cerevisiae may afford a useful host for the development of biodrugs and may provide an innovative system for the prevention or treatment of diseases that escape classical drug action. In particular, yeasts may provide a suitable vector for biodetoxication in the digestive environment.
A Microprocessor-based Hypercube Supercomputer (1986)

Each node in the NCUBE/ten parallel processor is organized around a custom, VAX-like, 32-bit CPU chip. With 1024 nodes, the NCUBE/ten provides a throughput of 500 MELOPS.
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. (1995)

Several polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--i.e., without the addition of cell targeting or membrane-disruption agents. This observation led us to test the cationic polymer polyethylenimine (PEI) for its gene-delivery potential. Indeed, every third atom of PEI is a protonable amino nitrogen atom, which makes the polymeric network an effective "proton sponge" at virtually any pH. Luciferase reporter gene transfer with this polycation into a variety of cell lines and primary cells gave results comparable to, or even better than, lipopolyamines. Cytotoxicity was low and seen only at concentrations well above those required for optimal transfection. Delivery of oligonucleotides into embryonic neurons was followed by using a fluorescent probe. Virtually all neurons showed nuclear labeling, with no toxic effects. The optimal PEI cation/anion balance for in vitro transfection is only slightly on the cationic side, which is advantageous for in vivo delivery. Indeed, intracerebral luciferase gene transfer into newborn mice gave results comparable (for a given amount of DNA) to the in vitro transfection of primary rat brain endothelial cells or chicken embryonic neurons. Together, these properties make PEI a promising vector for gene therapy and an outstanding core for the design of more sophisticated devices. Our hypothesis is that its efficiency relies on extensive lysosome buffering that protects DNA from nuclease degradation, and consequent lysosomal swelling and rupture that provide an escape mechanism for the PEI/DNA particles.
Coherent Quantum Evolution via Reservoir Driven Holonomies (2006)

We show that in the limit of a strongly interacting environment a system initially prepared in a decoherence-free subspace (DFS) coherently evolves in time, adiabatically following the changes of the DFS. If the reservoir cyclicly evolves in time, the DFS states acquire a holonomy.
Driving context and visual-manual phone tasks influence glance behavior in naturalistic driving (2014)

Naturalistic driving studies show that drivers engaged in complex visual-manual tasks face an increased risk of a crash or near-crash. Tasks that require many glances and a high proportion of long glances away from the road are of special concern for safety. Driving context (e.g. turning maneuvers, presence of lead or oncoming vehicles, vehicle speed) may also influence drivers’ glance behavior during normal driving, since the drivers may have to estimate curvature and anticipate potential threats (e.g., lead vehicle braking). However, the effect of driving context on glance behavior during visual-manual tasks has not yet been thoroughly investigated in naturalistic driving. The extent to which drivers adapt their glance behavior to changes in the road environment during secondary tasks is likely to influence their ability to compensate for and respond to changes in the road environment. The present study investigated for the first time the effect of both driving context and visual-manual phone tasks (i.e., dialing, texting, reading) on drivers’ glance behavior in naturalistic driving. This study shows that drivers indeed spend more time looking at the road and have a lower proportion of long off-road glances in complex driving contexts such as when turning and when lead or oncoming vehicles are present, both in normal driving and while engaged in a visual-manual phone task. In particular, these findings are more pronounced during turning maneuvers and in the presence of oncoming vehicles than in the presence of lead vehicles. Interestingly, driving speed influenced off-road glance durations during the phone tasks, but not during normal driving. The results from this study highlight the need to take driving context into account when evaluating the influence of different secondary tasks, in-vehicle user interfaces and glance metrics on driving safety, including the risk of crash involvement. The finding that glance behavior is context-dependent in a naturalistic setting has further implications for distraction detection algorithms, driver support systems, and driver training. Finally, driving contexts should be matched when comparing glance behavior, while driving with and without secondary tasks.
The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production (2010)

The role of neuroinflammation is increasingly being recognised in a diverse range of cerebral pathologies, including traumatic brain injury (TBI). We used cerebral microdialysis and paired arterial and jugular bulb plasma sampling to characterise the production of 42 cytokines after severe TBI in 12 patients over 5 days. We compared two microdialysis perfusates in six patients: central nervous system perfusion fluid and 3.5% human albumin solution (HAS); 3.5% HAS has a superior fluid recovery (95.8 versus 83.3%), a superior relative recovery in 18 of 42 cytokines (versus 8 of 42), and a qualitatively superior recovery profile. All 42 cytokines were recovered from the human brain. Sixteen cytokines showed a stereotyped temporal peak, at least twice the median value for that cytokine over the monitoring period; day 1: tumour necrosis factor, interleukin (IL)7, IL8, macrophage inflammatory protein (MIP)1α, soluble CD40 ligand, GRO, IL1β, platelet derived growth factor (PDGF)-AA, MIP1β, RANTES; day 2: IL1 receptor antagonist (ra). IL6, granulocyte-colony stimulating factor (G-CSF), chemokine CXC motif ligand 10 (IP10); days 4 to 5: IL12p70, IL10. Brain extracellular fluid concentrations were significantly higher than plasma concentrations for 19 cytokines: basic fibroblast growth factor (FGF2), G-CSF, IL1α, IL1β, IL1ra, IL3, IL6, IL8, IL10, IL12p40, IL12p70, IP10, monocyte chemotactic protein (MCP)1, MCP3, MIP1α, MIP1β, PDGF-AA, transforming growth factor (TGF)α and vascular endothelial growth factor. No clear arterio-jugular venous gradients were apparent. These data provide evidence for the cerebral production of these cytokines and show a stereotyped temporal pattern after TBI.
Recombinant retroviral vector interferes with the detection of amphotropic replication competent retrovirus in standard culture assays. (1995)

Many protocols for gene therapy employ recombinant retroviral vectors, which are replication-defective retroviruses engineered to serve as gene delivery vehicles. The use of retroviral vectors for human gene therapy requires careful screening of vector-producing cell lines and culture supernatants to ensure the absence of replication competent retrovirus (RCR) in clinical products. In this study we have examined several different culture assays routinely used to test for the presence of RCR. Results indicate that cocultivation of a vector-producing cell line with a permissive cell line can reproducibly detect a low level of contaminating RCR. RCR was detected less frequently in direct tests of cell-free culture supernatants from a contaminated vector-producing line. Further studies revealed that recombinant retroviral vector can interfere, to varying degrees, with the detection of low-level RCR in culture supernatants when a marker rescue assay, an extended mink S+L- assay or a PG-4 S+L- assay is used. Interference can be partially overcome by culturing the vector preparation with a permissive cell line for several days before testing on the indicator cell line. The interference phenomenon we have observed may also occur in other culture assays routinely used for the detection of RCR.
Association of Myocarditis with High Viral Load of Porcine Circovirus Type 2 in Several Tissues in Cases of Fetal Death and High Mortality in Piglets. A Case Study (2007)

During a period of 1.5 months, a newly established pig herd experienced a high number of mummifications and stillbirths, a high neonatal mortality rate, and many piglets with congenital tremors or hind leg ataxia. After clinical and histological investigations, the submitted animals were divided into 4 groups: mummified or stillborn (N = 6), live born with myocarditis (N = 5) (average age 22.8 days), live born without myocarditis (N = 14) (average age 20.0 days), and control animals from a different herd (N = 5) (newborn). Statistically significant differences were observed in the mean porcine circovirus 2 (PCV2) load among the 4 groups in the liver (P < 0.0001). The presence of PCV2 antigen within the myocardial lesions was confirmed by immunohistochemistry. A high load of PCV2 DNA was observed in myocardium, liver, and spleen from mummified or stillborn piglets (>1 x 10(7) copies per 500 ng DNA), lower in piglets with myocarditis (>1 x 10(5) copies per 500 ng DNA), and even further lower in pigs without myocarditis (<1 x 10(5) copies per 500 ng DNA), whereas no PCV2 DNA was detected in the control animals. Myocardium, liver, and spleen were well suited for routine testing of fetuses and young piglets by quantitative real-time polymerase chain reaction. Neither porcine parvovirus nor encepaholomyocarditis virus was detected. These results indicate that the PCV2 infection might have been of etiological importance for the fetal deaths and piglet mortality observed in this herd.
Physical properties and packing states of molecular assemblies of synthetic glycolipids in aqueous dispersions (1998)

Amidic glycolipids, 1,5-bis-O-alkyl-N-maltooligonoyl-L-glutamate (1), having various lengths of two hydrocarbon chains (carbon number, m: 14, 16, 18) and maltooligotose with (glucose unit, n: 3, 5, 7) and a N-glycosidic lipid, 1,5-bis-O-octadecyl-N-maltopentaonosyl-L-glutamate (2) have been synthesized. The assembling structures were analyzed by microscopic observation, such as negatively stained TEM, cryo-TEM, and AFM. The glycolipid 1a (m,n: 14,5) showed a fiber-like structure in all the observed temperatures, while 1b (16,5) showed a fiber-like structure when the hydrating temperature was above the gel-to-liquid crystalline phase transition temperature (Tc; 45°C) and a large disk-like structure when incubated below the Tc. The glycolipid 1c (18,5) took a large disk-like structure after hydration of the powder above the Tc. The glycolipids 1d (18,3) and 1e (18,7) showed a mixture of large disks and large vesicles and a mixture of small disks and micelles, respectively. The N-glycosidic lipid, 2, with no amide linkage made a vesicular structure only. The preparation procedure using high shear stress, such as extrusion and sonication, converted the large disk of 1c to smaller assemblies, such as small disk-, cone-, and granule-like assemblies, depending on the preparation conditions. The glycolipid molecules in the planer part of the disk were packed so tightly that molecular mobility was very low even above the Tc (58°C), and the reactivity of the saccharide chain against Concanavalin A was also very low, indicating that the high reactivity probably comes from the loose packing of saccharide chains around the edge part of the assemblies.
Simultaneous in vivo positron emission tomography and magnetic resonance imaging (2008)

Positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used in vivo imaging technologies with both clinical and biomedical research applications. The strengths of MRI include high-resolution, high-contrast morphologic imaging of soft tissues; the ability to image physiologic parameters such as diffusion and changes in oxygenation level resulting from neuronal stimulation; and the measurement of metabolites using chemical shift imaging. PET images the distribution of biologically targeted radiotracers with high sensitivity, but images generally lack anatomic context and are of lower spatial resolution. Integration of these technologies permits the acquisition of temporally correlated data showing the distribution of PET radiotracers and MRI contrast agents or MR-detectable metabolites, with registration to the underlying anatomy. An MRI-compatible PET scanner has been built for biomedical research applications that allows data from both modalities to be acquired simultaneously. Experiments demonstrate no effect of the MRI system on the spatial resolution of the PET system and <10% reduction in the fraction of radioactive decay events detected by the PET scanner inside the MRI. The signal-to-noise ratio and uniformity of the MR images, with the exception of one particular pulse sequence, were little affected by the presence of the PET scanner. In vivo simultaneous PET and MRI studies were performed in mice. Proof-of-principle in vivo MR spectroscopy and functional MRI experiments were also demonstrated with the combined scanner.
A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice (1989)

A human acute lymphoblastic leukemia (ALL) cell line that was transplanted into immune-deficient SCID mice proliferated in the hematopoietic tissues, invaded various organs, and led to the death of the mice. The distribution of leukemic cells in SCID mice was similar to the course of the disease in children. A-1 cells marked with a retrovirus vector showed clonal evolution after the transplant. SCID mice that were injected with bone marrow from three patients with non-T ALL had leukemic cells in their bone marrow and spleen. This in vivo model of human leukemia is an approach to understanding leukemic growth and progression and is a novel system for testing new treatment strategies.
Expression of stem cell pluripotency factors during regeneration in newts (2009)

In this study, we present data indicating that mammalian stem cell pluripotency-inducing factors are expressed during lens and limb regeneration in newts. The apparent expression even in intact tissues and the ensued regulation during regeneration raises the possibility that these factors might regulate tissue-specific reprogramming and regeneration. Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613-1616, 2009. (c) 2009 Wiley-Liss, Inc.