gebhart/patrepeval huggingface dataset:
Biotelemeters for Space Flights and Fetal Monitoring (1999)

Pill-shaped biotelemeters originally designed for space flight applications will soon be used for monitoring the health of a fetus during and after in-utero fetal surgery. The authors developed a family of biotelemeters that are not only small enough for rodent studies on board the space shuttle or international space station, but also fit through a 10 mm trocar, a plastic tube that is used in endoscopic fetal surgery to obtain minimally invasive access to the fetus. The first 'pill' measures pressure and temperature, and is currently undergoing long-term leakage and biocompatibility tests. A second pill under development measures pH and temperature. A prototype of the 'pH-pill' has been built and successfully tested and is presently being miniaturized into the same dimensions as the 'pressure pill'. Additional pills measuring heart rate, ECG, other ions such as calcium and potassium, and eventually glucose and blood gases, will follow. All pills are designed for ultra-low power consumption yielding lifetimes of up to 10 months in order to meet the requirements of fetal monitoring, but also to provide the capability of long-term space station experiments. Each pill transmits its pulse-interval-modulated signal on a unique carrier frequency in the frequency range of 174-216MHz. A custom-designed multi-channel receiver demodulates and decodes each pill signal and sends the data to a LabVIEW program that performs real-time data analysis and display. A patent for the pill family and its data analysis system is pending.
Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization (1985)

Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).
Chemically related antigens compete for presentation by accessory cells to T cells. (1982)

Immune responsiveness of guinea pigs to dinitrophenyl-poly-L-lysine (DNP-PLL) and to the lysine-rich random copolymer of L-glutamic acid and L-lysine (GL) are both controlled by the "poly-L-lysine gene." We demonstrate that accessory cells of responder strains can be made incapable of presenting DNP-PLL to response T cells in assays for proliferation by in vitro exposure of the cells to GL before and during their exposure to DNP-PLL. The inhibition was not rapidly reversible, because GL preexposed accessory cells that were cultured for 2 hr in GL-free medium were still refractory to pulsing with DNP-PLL. In contrast, DNP-PLL had only a moderate inhibitory effect on accessory cell presentation of GL. Unconjugated poly- and oligo-lysines also inhibited the ability of accessory cells to present DNP-PLL, but inhibitory activity was displayed only by homopolymers containing eight to 12 or more residues in the chain. The homopolymers of D-lysine, L-arginine, and L-glutamic acid, and lysine-free glutamic acid-rich copolymers had little or no inhibitory effect. The results are interpreted to mean that antigens to which responsiveness is regulated by the same Ir gene compete for presentation by accessory cells. This may reflect a competition for the Ir gene product of the antigen-presenting cell.
SUCCESSFUL CULTURE IN VITRO OF SHEEP AND CATTLE OVA (1972)

Fertilized sheep and cattle ova have not been reported to develop readily during culture in vitro. Up to 60% of sheep morulae develop normally during culture (Moor &amp; Cragle, 1971) but earlier cleavage stages undergo limited development (Hancock, 1963; Kraemer, 1966; Tervit &amp; McDonald, 1969; Moore, 1970) and it has been suggested that there is a block to development in vitro at the eight- to twelve-cell stage (Wintenberger, Dauzier &amp; Thibault, 1953). Only the early cleavage stages of cattle ova have been cultured and these have not been reported to develop beyond the twenty-four-cell stage in vitro (Thibault, 1966; Brinster, 1968; Sreenan, 1968; Sreenan, Scanlon &amp; Gordon, 1968). This communication describes the successful culture of one-cell to eight-cell sheep ova and one-cell and eight-cell cattle ova to the morula and blastocyst stages and reports a high embryo survival after transfer of cultured ova to recipient animals. Welsh mountain ewes were induced to superovulate and were mated at the
REGULATION OF THE MOVEMENT OF SOLUTES ACROSS TIGHT JUNCTIONS (1998)

The intercellular tight junction is the rate-limiting barrier in the paracellular pathway for permeation by ions and larger solutes. A variety of widely used electrical and flux approaches are used in the analyses of solute permeation through this pathway; however, each has limitations in practice. It is now clear that solute permeation across tight junctions is dynamically regulated by intracellular events with a common effector mechanism apparently tied to the cytoskeleton. These pathways, which regulate tight junction solute permeability, are targets that produce epithelial barrier dysfunction in a variety of disease states. However, regulation of solute permeation across the junctional barrier may also represent a potential means to improve bioavailability of orally administered bioactive solutes.
WDM Detection Using Integrated Grating Demultiplexer And High Density p-i-n Array (2005)

Multi-wavelength systems are being advocated for use in future telecommunication networks and for computer processor links.In research systems the multiplexing and demultiplexing of the different wavelength signals is currently achieved through the use of bulk optical components.When channel separation are on the order of a nm or so -which is typical of 'high density' direct detection systems -the MUX/DMUX function is generally done with a diffraction grating.WDM detection at the receiver end is then btained by assembling a detector array, placed in the focal plane of the optical grating system.
BRCA1 in hormonal carcinogenesis: basic and clinical research (2005)

The breast and ovarian cancer susceptibility gene-1 (BRCA1) located on chromosome 17q21 encodes a tumor suppressor gene that functions, in part, as a caretaker gene in preserving chromosomal stability. The observation that most BRCA1 mutant breast cancers are hormone receptor negative has led some to question whether hormonal factors contribute to the etiology of BRCA1-mutant breast cancers. Nevertheless, the caretaker function of BRCA1 is a generic one and does not explain why BRCA1 mutations confer a specific risk for tumor types that are hormone-responsive or that hormonal factors contribute to the etiology, including those of the breast, uterus, cervix, and prostate. An accumulating body of research indicates that in addition to its well-established roles in regulation of the DNA damage response, the BRCA1 protein interacts with steroid hormone receptors (estrogen receptor (ER-alpha) and androgen receptor (AR)) and regulates their activity, inhibiting ER-alpha activity and stimulating AR activity. The ability of BRCA1 to regulate steroid hormone action is consistent with clinical-epidemiological research suggesting that: (i) hormonal factors contribute to breast cancer risk in BRCA1 mutation carriers; and (ii) the spectrum of risk-modifying effects of hormonal factors in BRCA1 carriers is not identical to that observed in the general population. These data suggest a model for BRCA1 carcinogenesis in which genomic instability leads to the initiation of cancerous cell clones, while loss of normal restraint on hormonal stimulation of mammary epithelial cell proliferation allows amplification of these pre-existing clones. Further research will be required to substantiate this hypothesis.
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy (2013)

This study provides independent support of EPHA5-rs7349683 and XKR4-rs4737264 as the first markers of risk of paclitaxel induced neuropathy. In addition, it suggests that other EPHA genes also involved in axonal guidance and repair following neural injury, as well as LIMK2 locus, may play an important role in the development of this toxicity. The identified SNPs could form the basis for individualised paclitaxel chemotherapy.
High performance induction motor drive: A dither injection technique (2011)

In this paper, a three-level inverter fed induction motor drive operating under Direct Torque Control (DTC) is presented. DTC do not show good performance in low speed region due to stator flux demagnetization that relates to variation in stator resistance. Here, a sinusoidal wave is used as dither signal of minute amplitude (for torque hysteresis band and flux hysteresis band respectively) in the error block. Hence, this method is used to take care of the demagnetizing effect of flux vector near sector boundary. In this paper, sinusoidal dithering technique is applied to study the effect of settling time, flux demagnetizing effect, dc drift and initial value problem, flux and current ripple reduction. A laboratory prototype of the drive system has been developed and the simulation and experimental results are reported.
NEPHROTOXICITY FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION (1994)

Nephrotoxicity represents a serious side effect of immunosuppression following liver transplantation. In order to compare the nephrotoxic action of CsA and FK506 in a clinical setting, we evaluated the incidence of early and late nephrotoxicity in 121 patients, 60 of whom were randomly assigned to CsA- and 61 to FK506-based immunosuppression. Early postoperative renal insufficiency (between PODs 0 and 30; SCr 1.5–3 mg/dl) was observed to a similar extent in patients treated with CsA (38.3%) and FK506 (42.6%). Early postoperative acute renal failure (ARF) (SCr >3 mg/dl) was observed in 18.0% of patients in the FK506 treatment group and 18.3% of patients receiving CsA therapy. Approximately half the patients with ARF required hemodialysis (CsA: 11.7%; and FK506: 8.2%). All patients with early postoperative ARF requiring hemodialysis survived for more than one year. New onset of late ARF (between PODs 30 and 365) was observed in 6.6% of patients receiving FK506 therapy and in 1.7% in the CsA treatment group as a result of severe infection with multiple organ failure syndrome (MOFS). There was 100% mortality in patients with late ARF requiring hemodialysis. Etiology and prognosis of early and late ARF seem to be completely different. Early ARF was associated with severe coagulopathy and a rise in bilirubin and free hemoglobin, and was accompanied by impaired liver function. Mean onset of hemodialysis in CsA-treated patients was POD 1 and in FK506-treated patients POD 6, which disclosed a different time course of drug-specific nephrotoxicity of CsA and FK506 in early ARF. In contrast, late ARF
Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines. (1980)

Rat spleen cells activated in vitro by concanavalin A produce lymphokine molecules that possess biologic activity in a number of murine lymphocyte response assays. A single class of lymphokine most adequately described as T cell growth factor (TCGF, Interleukin-2) with a m.w. of 15,000 as estimated from gel filtration studies and with an isoelectric range of 5.4 to 5.6 stimulates i) the growth of established T cell lines in culture, ii) the proliferation of thymocytes in the presence of Con A under culture conditions where Con A alone is non-mitogenic, iii) the induction of antibody responses to heterologous erythrocyte antigens in athymic (nude) mouse spleen cell cultures, and iv) the generation of cytotoxic T lymphocytes (CTL) in thymocyte cultures and in nude mouse spleen cell cultures. We suggest that in each of the assay systems tested, this class of rat lymphokine acts directly on activated T cells. Nonactivated T cells must be stimulated by either mitogen or antigen before becoming responsive to lymphokine, but do not require antigen or mitogen for continued lymphokine-dependent proliferation. Similarly, human peripheral blood mononuclear cells activated by phytohemagglutinin (PHA) produce a class of lymphokines of identical size with an isoelectric point of 6.0 to 6.5 that possess the same biologic properties as measured in murine lymphocyte response systems.
Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors (2000)

Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). In situ binding and organ culture studies indicate that EDA-A1 and EDA-A2 are differentially expressed and play a role in epidermal morphogenesis.
Breast Cancer (1992)

StagingStaging refers to the grouping of patients according to the extent of their disease. Breast cancer is staged initially on a clinical basis, according to the results of the physical examination and laboratory and radiologic evaluations, and provides an important documentation of a patient's characteristics at presentation. This information can be useful in choosing treatments, estimating prognosis, and comparing the results of different treatment programs. An internationally recognized staging system — the TNM system — has been adopted by both the Union Internationale Contre le Cancer and the American Joint Commission on Cancer Staging and End-Results Reporting.100 This system . . .
Ghrelin Is Produced in Taste Cells and Ghrelin Receptor Null Mice Show Reduced Taste Responsivity to Salty (NaCl) and Sour (Citric Acid) Tastants (2010)

Background: The gustatory system plays a critical role in determining food preferences, food intake and energy balance. The exact mechanisms that fine tune taste sensitivity are currently poorly defined, but it is clear that numerous factors such as efferent input and specific signal transduction cascades are involved.
Allenes. Part 49. 4-Amino-2-(1-hydroxyalkyl)quinolines from phenylhydroxylamine and allenic nitrites (1989)

Allenic nitriles, when heated with phenylhydroxylamine in ethanol for 24 h, form the intermediate 2-alkylidene-4-amino-1,2-dihydro-1-hydroxyquinolines (4) which rearrange spontaneously by a 1,3-hydroxy shift to 4-amino-2-(1-hydroxyalkyl)quinolines. The 1-hydroxyquinoline intermediate (4) does not isomerise to 2-alkyl-4-aminoquinoline 1-oxide by a 1,4-proton shift as shown by an independent synthesis of the latter. Phenylpropynenitrile with phenylhydroxylamine gave 8% of 4-amino-2-(2-hydroxyphenyl)quinoline (15).
Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy (2013)

clinicaltrials.gov Identifier: NCT00768066.
LOX Expression and Functional Analysis in Astrocytomas and Impact of IDH1 Mutation (2015)

Lysyl oxidase (LOX) is involved in vital biological processes such as cell motility, cell signaling and gene regulation. Deregulation of this protein can contribute to tumor formation and progression. Although it is known that LOX is involved in invasion, proliferation and tumor migration in other types of tumors, studies of LOX in astrocytomas of different grades are scarce. The purpose of our study was to characterize LOX, BMP1 and HIF1A expression by real-time PCR in astrocytomas with WHO grades I to IV compared to non-neoplastic brain tissue. IDH1 mutational status was determined by PCR and sequencing. LOX protein expression was also analyzed by immunohistochemistry. LOX functional analyses were performed using siRNA knockdown and the specific inhibitor BAPN in two glioblastoma cell lines. The expression levels of LOX, BMP1 and HIF1A were correlated and analyzed according to IDH1 mutation status and to the clinical end-point of overall survival of glioblastoma patients. The results demonstrate that increased expression and activity of LOX, BMP1 and HIF1A were positively correlated with the malignant grade of astrocytomas. LOX protein expression also increased according to the degree of malignancy, with localization in the cytoplasm and nucleus and staining observed in endothelial cells. Glioblastoma with a mutation in IDH1 expressed lower levels of LOX in the nucleus, and IDH1-mutated cases showed lower LOX expression levels when compared to wild-type IDH1 cases. LOX knockdown and inhibition by BAPN in U87MG and A172 cell lines affected migration, invasion and soft agar colony formation. Taken together, these results corroborate the role of LOX in the migration, invasion and angiogenesis of astrocytomas. Furthermore, LOX expression is influenced by IDH1 mutational status. This work provides new insights for researchers aiming to design targeted therapies to control astrocytomas.
Expression of the kidney-associated differentiation glycoprotein gp160 and resistance to the antitumor effects of interferon alpha in renal cell carcinomas. (1998)

These data indicate that gp160/APA does not directly convey IFN-resistance to RCC cells and suggest that expression of gp160/APA in primary RCCs does not predict the benefit of IFN-alpha therapy.
Defining the Structure and Receptor Binding Domain of the Leaderless Bacteriocin LsbB (2014)

LsbB is a class II leaderless lactococcal bacteriocin of 30 amino acids. In the present work, the structure and function relationship of LsbB was assessed. Structure determination by NMR spectroscopy showed that LsbB has an N-terminal α-helix, whereas the C-terminal of the molecule remains unstructured. To define the receptor binding domain of LsbB, a competition assay was performed in which a systematic collection of truncated peptides of various lengths covering different parts of LsbB was used to inhibit the antimicrobial activity of LsbB. The results indicate that the outmost eight-amino acid sequence at the C-terminal end is likely to contain the receptor binding domain because only truncated fragments from this region could antagonize the antimicrobial activity of LsbB. Furthermore, alanine substitution revealed that the tryptophan in position 25 (Trp(25)) is crucial for the blocking activity of the truncated peptides, as well as for the antimicrobial activity of the full-length bacteriocin. LsbB shares significant sequence homology with five other leaderless bacteriocins, especially at their C-terminal halves where all contain a conserved KXXXGXXPWE motif, suggesting that they might recognize the same receptor as LsbB. This notion was supported by the fact that truncated peptides with sequences derived from the C-terminal regions of two LsbB-related bacteriocins inhibited the activity of LsbB, in the same manner as found with the truncated version of LsbB. Taken together, these structure-function studies provide strong evidence that the receptor-binding parts of LsbB and sequence-related bacteriocins are located in their C-terminal halves.
Removal of micro-organisms by filtration through unwoven cloth coated with a pyridinium-type polymer (1992)

Unwoven cloth coated with 32 mg/g of a copolymer of N-benzyl-4-vinyl-pyridinium chloride and styrene was found to be effective in removing micro-organisms from water. In experiments demonstrating removal of Escherichia coli by filtration through ten sheets of the unwoven cloth, the rate of removal was 99.99% at a filtration rate of 2.6 cm/h, and remained at 99% even at a high filtration rate of 300 cm/h and a low influent concentration of the bacterial cells such as 10(3) cells/ml. The rate of removal tended to increase with a decrease in the influent bacterial concentration. Seven other bacteria and two yeasts were effectively removed by filtration through the unwoven cloth. Filtration through the unwoven cloth was also effective in removing spores of fungi from water but was not very effective in removing bacteriophage T4 from aqueous solution.
Generation of a Bacterium with a 21 Amino Acid Genetic Code (2003)

We have generated a completely autonomous bacterium with a 21 amino acid genetic code. This bacterium can biosynthesize a nonstandard amino acid from basic carbon sources and incorporate this amino acid into proteins in response to the amber nonsense codon. The biosynthetic pathway for the amino acid p-aminophenylalanine (pAF) as well as a unique pAF synthetase and cognate tRNA were added to Escherichia coli. Denaturing gel electrophoresis and mass spectrometric analysis show that pAF is incorporated into myoglobin with fidelity and efficiency rivaling those of the common 20 amino acids. This and other such organisms may provide an opportunity to examine the evolutionary consequences of adding new amino acids to the genetic repertoire, as well as generate proteins with new or enhanced biological functions.
Intravenous Mononuclear Marrow Cells Reverse Neuropathic Pain from Experimental Mononeuropathy (2007)

These studies suggest that stem or progenitor cell-mediated therapies may be useful for the treatment of pain after nerve injury, and deserve further study to elucidate the mechanisms of analgesia.
Joint optimization of capacity and flow assignment for self-healing ATM networks (2002)

This paper addresses an optimal link capacity design problem for self-healing ATM networks. Given a projected traffic demand capacity and flow assignment is jointly optimized to find a truly optimal capacity placement. The problem can be formulated as a large-scale linear programming. The basis matrix can be readily factorized into an LU form by taking advantage of its special structure, which results in a great reduction on the computation time of the revised simplex method. The proposed method was tested on two sample networks for several random traffic demands. The results indicate that a significant amount of cost saving is possible through the joint optimization.
Flexible routing and addressing for a next generation IP (1994)

Due to a limited address space and poor scaling of backbone routing information, the Internet Protocol (IP) is rapidly reaching the end of its useful lifetime. The Simple Internet Protocol Plus (SIPP), a proposed next generation Internet Protocol, solves these problems with larger internet layer addresses. In addition, SIPP provides a number of advanced routing and addressing capabilities including mobility, extended (variable-length) addressing, provider selection, and certain forms of multicast. These capabilities are all achieved through a single mechanism, a generalization of the IP loose source route. We argue that, for reasons of simplicity and evolvability, a single powerful mechanism to achieve a wide range of routing and addressing functions is preferable to having multiple specific mechanisms, one for each function.