gebhart/patrepeval huggingface dataset:
New phosphoramidates as protecting groups in ribooligonucleotides synthesis. (1976)

N, N-Dimethyl-p-phenylenediamine, glycine amide and p-methylthioaniline were condensed with uridine 5'-phosphate and the phosphoramidates obtained were tested for their stability in anhydrous pyridine, 50% aqueous pyridine or 80% acetic acid. The p-methylthioanilidate (IIc) was oxidized to give p-methylsulfoxylanilidate of uridine 5'-phosphate (IId) which was found to be 5 times more stable than the p-methylthio compound. The p-methylsulfoxylanilidate of 2'-O-benzoyluridine 3'-phosphate was condensed with the mononucleotide to yield the dinucleotide, MMTrU(OBz)-p-U(OBz)-p in 28% yield.
QSAR of Adenosine Receptor Antagonists II: (2003)

Abstract Considering potential of selective adenosine receptor subtype ligands in the development of prospective drug candidates, A 1 and A 3 receptor binding affinity data of 2‐arylpyrazolo[3,4‐c]quinoline derivatives have been subjected to QSAR analyses to explore the physicochemical requirements for selective binding. The study has been carried out with Wang‐Ford charges of the common atoms of the molecules calculated from their energy minimized conformations using AM1 technique. Apart from the charge parameters, physicochemical variables like partition coefficient and molar refractivity of the whole molecules have been used along with suitable indicator variables. The study shows that substituents on the appended 2‐phenyl ring and 4‐amino or 4‐keto substitution on the pyrazolo[3,4‐c]quinoline nucleus modulate the selectivity pattern. Further, negative charge on the quinoline nitrogen and volume and lipophilicity of the whole molecules are important contributors to the selectivity.
JTIDS Relative Navigation with Measurement Sharing: Design and Performance (1986)

Alternative approaches for conducting relative navigation (relnav) using the joint tactical information distribution system (JTIDS) communication network are presented. The design and performance of the current JTIDS relnav with estimate sharing are discussed, including its shortcomings. We offer first a conceptually simpler alternate design that provides more accurate relnav between any pair of members, provided they have time to maneuver. A second alternative design includes the features of the first plus measurement sharing by designated primary members. It has even better performance including faster more accurate relnav fixes and relaxed maneuvering requirements. Simulation results are presented showing the superior performance of the new designs. The advantages and disadvantages of relnav with measurement sharing compared with relnav with estimate sharing are summarized.
Direct diode lasers with comparable beam quality to fiber, CO 2 , and solid state lasers (2012)

TeraDiode has produced kW-class ultra-high brightness fiber-coupled direct diode lasers. A fiber-coupled direct diode laser with a power level of 2,040 W from a 50 &mu;m core diameter, 0.15 numerical aperture (NA) output fiber at a single center wavelength was demonstrated. This was achieved with a novel beam combining and shaping technique using COTS diode lasers. The fiber-coupled output corresponds to a Beam Parameter Product (BPP) of 3.75 mm-mrad and is the lowest BPP kW-class direct diode laser yet reported. This laser is suitable for industrial materials processing applications, including sheet metal cutting and welding. This 2-kW fiber-coupled direct diode laser has comparable brightness to that of industrial fiber lasers and CO<sub>2</sub> lasers, and is over 10x brighter than state-of-the-art direct diode lasers.
Insights into the Mechanism of Ligand Binding to Octopine Dehydrogenase from Pecten maximus by NMR and Crystallography (2010)

Octopine dehydrogenase (OcDH) from the adductor muscle of the great scallop, Pecten maximus, catalyzes the NADH dependent, reductive condensation of L-arginine and pyruvate to octopine, NAD(+), and water during escape swimming and/or subsequent recovery. The structure of OcDH was recently solved and a reaction mechanism was proposed which implied an ordered binding of NADH, L-arginine and finally pyruvate. Here, the order of substrate binding as well as the underlying conformational changes were investigated by NMR confirming the model derived from the crystal structures. Furthermore, the crystal structure of the OcDH/NADH/agmatine complex was determined which suggests a key role of the side chain of L-arginine in protein cataylsis. Thus, the order of substrate binding to OcDH as well as the molecular signals involved in octopine formation can now be described in molecular detail.
<title>Image computing requirements for the 1990s: from multimedia to medicine</title> (1991)

Although the computer industry has begun incorporating new features in their newest computers and workstations, it has not been clear how best to utilize these new media to improve the productivity of the user. One problem stems from relative separation of various disciplines. For example, three distinct disciplines have evolved from visual information processing: image processing, computer graphics, and pattern recognition. All of them manipulate image data in some ways. The main difference between them is the domain where each discipline takes the input and produces the output. Recognizing the importance of merging the three distinct disciplines into one so that the image data can be successfully incorporated into the future computer technology, a new discipline, denoted as image computing, has been established to provide for consistency and efficiency in managing image data. In conjunction with other technologies such as video and computer-generated audio, image computing will play a key role in developing an integrated information processing platform that will be used in many areas in the 1990s. Some of the areas where image computing technology can be applied are presented. Requirements specific to each application are also described. Functions required of a typical computing workstation will be listed and each requirement will be investigated in detail. We describe how the continuing advances in technology will benefit image computing, and predict how the software algorithms of the future will be employed in image computing. We also introduce some possible future products that incorporate image computing technology.
Diagnostic and Statistical Manual of Mental Disorders (2013)

En la actualidad es importante detectar a tiempo la depresión, con el fin de llevar un tratamiento oportuno y mejorar la calidad de vida de las personas, este proceso de evaluación o detección requiere el uso de herramientas o test para llegar a un diagnóstico correcto por parte de profesionales de la salud mental, lo cual puede llegar a ser largo de realizar o en algunos casos ser muy invasivo para las personas. A través de este proyecto se llevó a cabo la investigación de los síntomas que caracterizan el perfil de una persona con depresión y el desarrollo de una aplicación que detecta los posibles síntomas, mediante el uso de webscraping en redes sociales como Instagram, el uso de algoritmos de machine learning, análisis de datos y análisis facial en conjunto para obtener un resultado mas completo del que se puede llegar a tener solo con el texto obtenido en las publicaciones o el análisis aplicado a los rostros. Durante el desarrollo se investigaron los rasgos mas notorios en personas o pacientes con síntomas de depresión, así como los cambios en el lenguaje que puedan generar, con el fin de detectarlo en el texto de las publicaciones, además se investigaron y probaron distintos algoritmos de machine learning con un conjunto de datos para clasificar las publicaciones en suicida o no suicida. Se implementaron módulos de webscraping, clasificación de palabras y una API de análisis facial para descargar y analizar las publicaciones de los perfiles. Durante el desarrollo encontraron varios obstáculos y consideraciones relacionadas a las políticas de uso de Instagram, el manejo de datos personales y los problemas que puede haber al trabajar con este tipo de datos y analizarlos. Este proyecto aporta una base o contexto para crear herramientas de análisis e investigación que sean capaces de detectar síntomas relacionados a la depresión y que trabajen de la mano con otros recursos de diagnóstico y validación clínica.
b2 integrin signaling in leukocytes (2000)

Members of the beta 2 integrin family are the dominating integrins expressed on leukocytes, and they play a major role in leukocyte cell-cell and cell-matrix adhesions during inflammation and other immune responses. Beta 2 integrins are signaling receptors, but they are also targets of and are functionally affected by intracellular signals. Accordingly, researchers usually discuss two types of signaling by beta 2 integrins (and integrins in general): transmission of signals into the cell following binding of ligands or counter-receptors to the integrins (outside-in signaling), and regulation of the avidity and conformation of integrins by signals generated by other receptors within the cell (inside-out signaling). In this review, our aim is to summarize what is known about the capacity of beta 2 integrins to generate outside-in signaling in leukocytes, in particular polymorphonuclear neutrophils. Results in the literature clearly demonstrate that one of the earliest events in beta 2 integrin signaling is activation of non-receptor tyrosine kinases, which in turn triggers downstream activation of various signaling pathways that affect different functional responses of the cell. We also discuss molecules of potential importance in beta 2 integrin signaling.
Effects of 1,25‐dihydroxyvitamin D3 and its 20‐epi analogues (MC 1288, MC 1301, KH 1060), on clonal keratinocyte growth: evidence for differentiation of keratinocyte stem cells and analysis of the modulatory effects of cytokines (1997)

1. Keratinocytes are functionally divided into stem cells, transit amplifying cells and terminally differentiated cells. In a hyperproliferative skin disease, psoriasis, increased mitotic activity of the stem cells is chiefly responsible for epidermal hyperplasia. The effects of 1,25dihydroxyvitamin D3 (1,25(OH)2D3) and potent vitamin D3 analogues (MC 1288: 20-epi-1,25(OH)2D3, MC 1301: 20-epi-24a-homo-26,27-dimethyl-1,25(OH)2D3, KH 1060: 20-epi-22-oxa-24a-homo-26,27-dimethyl-1,25(OH)2D3) on the stem cells were investigated. 2. Stem cells were identified retrospectively as those giving rise to large keratinocyte colonies in culture (holoclones). 1,25(OH)2D3 (10(-8)-10(-6) M) suppressed formation of holoclones by stimulating the progenitor cell differentiation into the phenotype expressing differentiation markers (keratins K1/K10 and involucrin). 3. 20-Epi vitamin D3 analogues were more potent than 1,25(OH)2D3 in inhibiting the clonal keratinocyte growth. This activity correlated with the ability to induce cell differentiation (KH 1060 > MC 1301 > MC 1288 > 1,25(OH)2D3). 4. Cytokines modulated the effects of 1,25(OH)2D3 on clonal growth. One of the following cytokines (epidermal growth factor, transforming growth factor alpha, interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8) was required for 1,25(OH)2D3 to suppress clonal growth and induce cell differentiation. In contrast, keratinocyte growth factor and insulin-like growth factor I attenuated the effects of 1,25(OH)2D3. 5. In conclusion, 1,25(OH)2D3 and 20-epi vitamin D3 analogues suppress clonal growth by directly inducing the differentiation of progenitor cells. It is conceivable that stimulation of stem cells differentiation is a major mechanism of action of vitamin D3 compounds in psoriasis. Balance between different types of cytokines in psoriatic epidermis may be an important factor determining the clinical effect of vitamin D-based therapy.
Evaluation of Carriers of Bone Morphogenetic Protein for Spinal Fusion (2001)

As a carrier for recombinant human bone morphogenetic protein-2, True Bone Ceramics, possessing a bony or porous structure, was more effective than a Type I collagen sheet in achieving a faster and stronger lumbar spinal fusion in a rabbit model.
Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer. (2013)

RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC.
Effects of dexamethasone on posterior capsule opacification-like changes in a rat lens explant model. (2004)

Lens cell behavior in this PCO model was significantly affected by inclusion of DEX, highlighting the possibility that its use as an anti-inflammatory at the time of cataract surgery may influence PCO development.
Homolactate Fermentation by Metabolically Engineered Escherichia coli Strains (2006)

We report the homofermentative production of lactate in Escherichia coli strains containing mutations in the aceEF, pfl, poxB, and pps genes, which encode the pyruvate dehydrogenase complex, pyruvate formate lyase, pyruvate oxidase, and phosphoenolpyruvate synthase, respectively. The process uses a defined medium and two distinct fermentation phases: aerobic growth to an optical density of about 30, followed by nongrowth, anaerobic production. Strain YYC202 (aceEF pfl poxB pps) generated 90 g/liter lactate in 16 h during the anaerobic phase (with a yield of 0.95 g/g and a productivity of 5.6 g/liter . h). Ca(OH)(2) was found to be superior to NaOH for pH control, and interestingly, significant succinate also accumulated (over 7 g/liter) despite the use of N(2) for maintaining anaerobic conditions. Strain ALS961 (YYC202 ppc) prevented succinate accumulation, but growth was very poor. Strain ALS974 (YYC202 frdABCD) reduced succinate formation by 70% to less than 3 g/liter. (13)C nuclear magnetic resonance analysis using uniformly labeled acetate demonstrated that succinate formation by ALS974 was biochemically derived from acetate in the medium. The absence of uniformly labeled succinate, however, demonstrated that glyoxylate did not reenter the tricarboxylic acid cycle via oxaloacetate. By minimizing the residual acetate at the time that the production phase commenced, the process with ALS974 achieved 138 g/liter lactate (1.55 M, 97% of the carbon products), with a yield of 0.99 g/g and a productivity of 6.3 g/liter . h during the anaerobic phase.
Interstitial laser hyperthermia (1992)

Experimental studies have shown that once the appropriate laser parameters are defined, interstitial laser hyperthermia (ILH) can produce well-defined, predictable tissue necrosis in solid viscera which heal safely with little functional or structural sequelae. Preliminary clinical studies have illustrated that ILH is simple to perform, is well tolerated producing radiological and histological evidence of necrosis in liver, pancreatic, and breast cancer. Its future role in most cases will be palliative, controlling local tumour growth. Where the extent of necrosis can be matched accurately to tumour volume, the prospect for cure exists. Further research is necessary before ILH can be regarded as an established treatment and, in particular, its influence on patient survival is worthy of further evaluation.
General anesthetics. 1. Halogenated methyl ethyl ethers as anesthetic agents (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral anesthetics. 1. Halogenated methyl ethyl ethers as anesthetic agentsRoss C. Terrell, Louise Speers, Alex J. Szur, John Treadwell, and Thomas R. UcciardiCite this: J. Med. Chem. 1971, 14, 6, 517–519Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/jm00288a014https://doi.org/10.1021/jm00288a014research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bisphosphonate-Associated Osteonecrosis of the Jaws: A Guide for the General Dental Practitioner (2006)

General dental practitioners have a key role to play in identifying patients at risk of developing bisphosphonate-associated osteonecrosis of the jaws, preventing occurrence of the condition and initiating early specialist referral.
Rapid Micro-Raman Imaging Using Fiber-Bundle Image Compression (1997)

A new technique for rapid Raman imaging and chemical analysis of micro-composites and biomaterials, with potential applications in real-time robotic vision, automated manufacturing, and medical imaging, is described and demonstrated. The key feature of this new instrument is a fiber-optic bundle used to compress two-dimensional images onto a one-dimensional fiber stack, which serves as the entrance slit of an imaging optical spectrograph. Thus a complete Raman spectrum is simultaneously collected from every point within a sample in a single scan of a charge-coupled-device (CCD) detector. The method is demonstrated by using Raman imaging of a microscopic mixed-salt sample. Its efficiency relative to alternative Raman imaging methods is quantitatively evaluated, and potential applications in other spectral imaging measurements are discussed. Index Headings: Raman spectroscopy; Spectral imaging; Chemical imaging; Fiber optics; Chemical sensor.
Aldehyde‐Amine Chemistry Enables Modulated Biosealants with Tissue‐Specific Adhesion (2009)

The interfacial regions between PEG: dextran-based adhesive sealant and excised rat heart, lung, liver, and duodenum tissues exhibit three distinct domains; target tissue (red and blue), bulk material (green), and an adhesive regime interposed between the two. The variation in adhesive regime morphology when applied to different tissues provides a rational approach for the engineering of application-specific surgical sealants.
Yellowfever Mosquitoes: Compounds Related to Lactic Acid that Attract Females1 (1973)

Journal Article Yellowfever Mosquitoes: Compounds Related to Lactic Acid that Attract Females Get access David A. Carlson, David A. Carlson Insects Affecting Man Laboratory, Agric. Res. Serv, USDA, Gainesville, Fla. 32601 Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Smith, N. Smith Insects Affecting Man Laboratory, Agric. Res. Serv, USDA, Gainesville, Fla. 32601 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. K. Gouck, H. K. Gouck Insects Affecting Man Laboratory, Agric. Res. Serv, USDA, Gainesville, Fla. 32601 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. R. Godwin D. R. Godwin Insects Affecting Man Laboratory, Agric. Res. Serv, USDA, Gainesville, Fla. 32601 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 66, Issue 2, 16 April 1973, Pages 329–331, https://doi.org/10.1093/jee/66.2.329 Published: 16 April 1973 Article history Received: 18 September 1972 Published: 16 April 1973
Identification of Fibroblast Growth Factor 9 (FGF9) as a High Affinity, Heparin Dependent Ligand for FGF Receptors 3 and 2 but not for FGF Receptors 1 and 4 (1995)

Fibroblast growth factors (FGF) are multifunctional, heparin binding polypeptides that share structural similarity, but differ in their target cell specificity and expression pattern. Here we describe the cloning and expression of the mouse homologue of FGF9, and the use of a panel of soluble FGF receptors and genetically engineered cells to study its receptor binding specificity. FGF9 is found to bind with high affinity (kd: 0.25 nM) to FGFR3, for which a specific ligand has not yet been identified. FGF9 can also bind, albeit with a lower affinity, to FGFR2 but does not bind FGFR1 or FGFR4. There is no significant binding to either FGFR3 or FGFR2, expressed either as soluble receptors or in heparin sulfate deficient cells, in the absence of heparin. Moreover, receptor binding of FGF9 requires heparin in a manner specific to the receptor type. In conclusion FGF9 presents a unique case of ligand-receptor specificity and fulfills the criteria as a high affinity, heparin-dependent ligand for FGFR3.
A Modular Vaccine Development Platform Based on Sortase-Mediated Site-Specific Tagging of Antigens onto Virus-Like Particles (2016)

Virus-like particles (VLPs) can be used as powerful nanoscale weapons to fight against virus infection. In addition to direct use as vaccines, VLPs have been extensively exploited as platforms on which to display foreign antigens for prophylactic vaccination and immunotherapeutic treatment. Unfortunately, fabrication of new chimeric VLP vaccines in a versatile, site-specific and highly efficient manner is beyond the capability of traditional VLP vaccine design approaches, genetic insertion and chemical conjugation. In this study, we described a greatly improved VLP display strategy by chemoenzymatic site-specific tailoring antigens on VLPs surface with high efficiency. Through the transpeptidation mediated by sortase A, one protein and two epitopes containing N-terminal oligoglycine were conjugated to the LPET motif on the surface of hepatitis B virus core protein (HBc) VLPs with high density. All of the new chimeric VLPs induced strong specific IgG responses. Furthermore, the chimeric VLPs with sortase A tagged enterovirus 71 (EV71) SP70 epitope could elicit effective antibodies against EV71 lethal challenging as well as the genetic insertion chimeric VLPs. The sortase A mediated chemoenzymatic site-specific tailoring of the HBc VLP approach shows great potential in new VLP vaccine design for its simplicity, site specificity, high efficiency, and versatility.
Designing Tone Reservation PAR Reduction (2006)

Tone reservation peak-to-average (PAR) ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM) systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.
A New Y3Al5O12 Phase Produced by Liquid‐Feed Flame Spray Pyrolysis (LF‐FSP) (2005)

Liquid-feed flame spray pyrolysis allows the synthesis of 20 nm diameter hexagonal Y3Al5O12 nanopowders (see Figure) that show no evidence of a yttrium aluminum garnet (YAG) phase. The nanopowders can be easily formed into green bodies that sinter to the YAG phase at nearly full density. This novel material offers potential for making high-quality YAG materials including ceramic lasers with exceptional control of processing parameters.