gebhart/patrepeval huggingface dataset:
Extracting Ordered Patterns from a Triangular Mesh Surface (2011)

The last decade has witnessed the proliferation of three-dimensional (3-D) digitizers and scanners as well as substantial developments in techniques for modeling and digitizing 3-D shapes. Basically, shape digitalization can be defined as the process of encoding the surface shape into a discrete format suitable for computing purposes, such as analysis and modeling. Surface tessellation is the backbone of surface digitalization, whereby the surface is encoded by a group of stitched polygons that cover the whole surface. Tessellation can be performed using polygons of any order, but triangles are the most commonly used. Indeed, a triangular mesh is characterized by its simplicity and flexibility. Contrary to other polygons, the triangle is the only polygon in which the vertices are guaranteed to be coplanar. This made triangular mesh the format most supported by graphics software and hardware. Triangular meshes are used in animation, simulation training, architecture, medical and natural sciences, and many other applications.
Temperature and Strain-Rate Dependence of Surface Dislocation Nucleation (2008)

Dislocation nucleation is essential to the plastic deformation of small-volume crystalline solids. The free surface may act as an effective source of dislocations to initiate and sustain plastic flow, in conjunction with bulk sources. Here, we develop an atomistic modeling framework to address the probabilistic nature of surface dislocation nucleation. We show the activation volume associated with surface dislocation nucleation is characteristically in the range of 1-10b3, where b is the Burgers vector. Such small activation volume leads to sensitive temperature and strain-rate dependence of the nucleation stress, providing an upper bound to the size-strength relation in nanopillar compression experiments.
Allogeneic MHC‐mismatched activated natural killer cells administered after bone marrow transplantation provide a strong graft‐versus‐leukaemia effect in mice (1997)

Allogeneic lymphocytes administered with an unmanipulated bone marrow transplant provide a strong antileukaemic effect, the so-called graft-versus-leukaemia (GVL) effect. On the other hand, T-cell-mediated graft-versus-host-disease (GVHD) observed after transplantation of unmanipulated BM graft causes substantial morbidity and mortality. The aim of the present study was to determine the antileukaemic potential of enriched IL-2 activated NK cells administered 2 h after BMT. Balb/c (H-2d) mice were given a dose of A20 (H-2d, B-cell leukaemia) cells 2 d prior to lethal total body irradiation (TBI) and transplantation of either syngeneic or allogeneic anti-Thy1.2 (CD90) depleted bone marrow cells. Either syngeneic (Balb/c, H-2d) or allogeneic (C57BL/6, H-2b) enriched and IL-2 (200 U/ml for 24 h) activated NK cells were given 2 h after BMT. Injection of A20 leukaemia into normal Balb/c recipients led to death after a median of 14 d. A lethal dose of TBI followed by either syngeneic or allogeneic Thy1.2-depleted BMT resulted in a modest antileukaemic effect. The adoptive transfer of syngeneic enriched and IL-2 preincubated NK cells given at time of BMT exerted a significantly better GVL effect. However, the infusion of allogeneic enriched NK cells resulted in a stronger GVL effect. These results clearly demonstrate that allogeneic NK cells are superior to syngeneic NK cells in their potential to eradicate residual leukaemia cells after BMT without mediating clinical overt GVHD. This experimental setting may offer a strategy for treatment of haematological malignancies in a phase of minimal residual disease.
Power line sensor networks for enhancing power line reliability and utilization (2011)

Over the last several decades, electricity consumption and generation have continually grown. Investment in the Transmission and Distribution (T&amp;D) infrastructure has been minimal and it has become increasingly difficult and expensive to permit and build new power lines. At the same time, a growing increase in the penetration of renewable energy resources is causing an unprecedented level of dynamics on the grid. Consequently, the power grid is congested and under stress. \nTo compound the situation, the utilities do not possess detailed information on the status and operating margins on their assets in order to use them optimally. The task of monitoring asset status and optimizing asset utilization for the electric power industry seems particularly challenging, given millions of assets and hundreds of thousands of miles of power lines distributed geographically over millions of square miles. The lack of situational awareness compromises system reliability, and raises the possibility of power outages and even cascading blackouts.\nTo address this problem, a conceptual Power Line Sensor Network (PLSN) is proposed in this research. The main objective of this research is to develop a distributed PLSN to provide continuous on-line monitoring of the geographically dispersed power grid by using hundreds of thousands of low-cost, autonomous, smart, and communication-enabled Power Line Sensor (PLS) modules thus to improve the utilization and reliability of the existing power system.\nThe proposed PLSN specifically targets the use of passive sensing techniques, focusing on monitoring the real-time dynamic capacity of a specific span of a power line under present weather conditions by using computational intelligence technologies. An ancillary function is to detect the presence of incipient failures along overhead power lines via monitoring and characterizing the electromagnetic fields around overhead conductors. This research integrates detailed modeling of the power lines and the physical manifestations of the parameters being sensed, with pattern recognition technologies. Key issues of this research also include design of a prototype PLS module with integrated sensing, power and communication functions, and validation of the Wireless Sensor Network (WSN) technology integrated to this proposed PLSN.
Formal approach and automated tool for constructing ontology from object-oriented database model (2010)

Extracting domain knowledge from databases can facilitate the development of Web ontologies. In this paper, a formal approach and an automated tool for constructing ontologies from Object-oriented database models (OODMs) are developed. The approach and tool can automatically translate an OODM and its corresponding database instances into the ontology structure and ontology instances, respectively. Case studies show that the approach is feasible and the automated construction tool is efficient.
A Novel Capacitorless 1T DRAM Cell for Data Retention Time Improvement (2010)

This paper proposes a silicon-with-partially-insulating-layer-on-silicon-on-insulator (SISOI) one-transistor dynamic random access memory (1T DRAM) cell to increase data retention time. A conventional 1T DRAM cell has a data retention problem because it stores holes in an SOI layer, which is not separated from the source/drain region. However, the proposed SISOI 1T DRAM cell can keep holes electrically separated from the source/drain region, which leads to the increase of data retention time.
Analysis of two carbon-13 NMR correlations for determining the stereochemistry of 1,3-diol acetonides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of two carbon-13 NMR correlations for determining the stereochemistry of 1,3-diol acetonidesScott D. Rychnovsky, Bruce Rogers, and Guang YangCite this: J. Org. Chem. 1993, 58, 13, 3511–3515Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00065a011https://doi.org/10.1021/jo00065a011research-articleACS PublicationsRequest reuse permissionsArticle Views2507Altmetric-Citations315LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A methodological framework for data warehouse design (1998)

Though designing a data warehouse requires techniques completely different from those adopted for operational systems, no significant effort has been made so far to develop a complete and consistent design methodology for data warehouses. In this paper we outline a general methodological framework for data warehouse design, based on our Dimensional Fact Model (DFM). After analyzing the existing information system and collecting the user requirements, conceptual design is carried out semi-automatically starting from the operational database scheme. A workload is then characterized in terms of data volumes and expected queries, to be used as the input of the logical and physical design phases whose output is the final scheme for the data warehouse.
Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference (2002)

The RNA interference (RNAi) phenomenon is a recently observed process in which the introduction of a double-stranded RNA (dsRNA) into a cell causes the specific degradation of a mRNA containing the same sequence. The 21-23 nt guide RNAs, generated by RNase III cleavage from longer dsRNAs, are associated with sequence-specific mRNA degradation. Here, we show that dsRNA specifically suppresses the expression of HIV-1 genes. To study dsRNA-mediated gene interference in HIV-1-infected cells, we have designed six long dsRNAs containing the HIV-1 gag and env genes. HIV-1 replication was totally suppressed in a sequence-specific manner by the dsRNAs in HIV-1-infected cells. Especially, E2 dsRNA containing the major CD4-binding domain sequence of gp120, as the target of the HIV-1 env gene, dramatically inhibited the expression of the HIV-1 p24 antigen in PBMCs for a relatively long time. The dsRNA interference method seems to be a promising new strategy for anti-HIV-1 gene therapeutics.
Why and how are peptide-lipid interactions utilized for self defence? (2001)

Animals defend themselves against invading pathogenic micro-organisms by utilizing cationic anti-microbial peptides, which rapidly kill various micro-organisms without exerting toxicity against the host. Physicochemical peptide-lipid interactions provide attractive mechanisms for innate immunity. Many of these peptides form amphipathic secondary structures (alpha-helices and beta-sheets) which can selectively interact with anionic bacterial membranes by electrostatic interaction. Rapid, peptide-induced membrane permeabilization is an effective mechanism of anti-microbial action. Magainin 2 from frog skin forms a dynamic peptide-lipid supramolecular-complex pore that allows mutually coupled transmembrane transport of ions and lipids. The peptide molecule is internalized upon the disintegration of the pore. Several anti-microbial peptides are known to work synergistically.
Structural variety of arginine-rich RNA-binding peptides. (1995)

Arginine-rich domains are used by a variety of RNA-binding proteins to recognize specific RNA hairpins. It has been shown previously that a 17-aa arginine-rich peptide from the human immunodeficiency virus Rev protein binds specifically to its RNA site when the peptide is in an alpha-helical conformation. Here we show that related peptides from splicing factors, viral coat proteins, and bacteriophage antiterminators (the N proteins) also have propensities to form alpha-helices and that the N peptides require helical conformations to bind to their cognate RNAs. In contrast, introducing proline mutations into the arginine-rich domain of the human immunodeficiency virus Tat protein abolishes its potential to form an alpha-helix but does not affect RNA-binding affinity in vitro or in vivo. Based on results from several peptide-RNA model systems, we suggest that helical peptides may be used to recognize RNA structures having particularly wide major grooves, such as those found near loops or large bulges, and that nonhelical or extended peptides may be used to recognize less accessible grooves.
Multivalent Vancomycins and Related Antibiotics Against Infectious Diseases (2005)

This review discusses the recent development of multivalent antibiotics as potential therapeutic agents against infections caused by antimicrobial drug resistant microbes. The discussion focuses on vancomycin because of its important clinical relevance and well-elucidated molecular mechanism of antimicrobial drug resistance. The first section recounts the increased occurrence of vancomycin resistance in the world; the second section briefly discusses the mechanistic study of vancomycin resistance; the third section presents the currently established design principles of multivalent vancomycins; the fourth section examines the structural-activity relationships of multivalent vancomycins; the fifth section describes relevant studies on multivalent antibiotics; and the last section summarizes advantages and limitations of multivalent antibiotics.
In Vivo Augmentation of Natural Killer Activity by Combined Treatment with Recombinant Gamma Interferon and Interleukin-2 (1985)

The in vivo regulation of natural killer (NK) cell function by recombinant murine gamma interferon (rMuIFN-gamma) and recombinant human interleukin-2 (rHuIL-2) was investigated. Peritoneal exudate-derived natural killer (PE-NK) cells of mice treated with rMuIFN-gamma or rHuIL-2 exhibited significantly enhanced cytolytic activities against YAC-1 target cells. Compared with animals receiving treatment with either rMuIFN-gamma or rHuIL-2 alone, the sequential treatment of mice with both agents resulted in a significantly greater enhancement of PE-NK cell function, especially when rMuIFN-gamma was administered 24 h before treatment with rHuIL-2. The cytolytic activities were significantly diminished after pretreatment of effector cells with anti-Qa-5 antiserum and complement but not with anti-Lyt-3.2 antiserum. These data constitute the first evidence demonstrating the association between IFN-gamma and IL-2 in the regulation of NK cell function in vivo, reinforce the potential benefit of combined treatment with biological response modifiers, and show that the schedule of administration may be a critical requirement for optimal benefits of combined lymphokine treatment in vivo.
Gate driver for SiC JFETs with protection against normally-on behaviour induced fault (2011)

A fast gate driver for normally-on silicon carbide (SiC) junction field-effect transistors (JFETs) is presented. It includes a protection feature against short-circuits due to the normally-on behaviour of the JFETs.
Optimization of ultrafiltration/diafiltration processes for partially bound impurities (2004)

Ultrafiltration and diafiltration processes are used extensively for removal of a variety of small impurities from biological products. There has, however, been no experimental or theoretical analysis of the effects of impurity- product binding on the rate of impurity removal during these processes. Model calculations were performed to account for the effects of equilibrium binding between a small impurity and a large (retained) product on impurity clearance. Experiments were performed using D-tryptophan and bovine serum albumin as a model system. The results clearly demonstrate that binding interactions can dramatically reduce the rate of small impurity removal, leading to large increases in the required number of diavolumes. The optimal product concentration for performing the diafiltration shifts to lower product concentrations in the presence of strong binding interactions. Approximate analytical expressions for the impurity removal were developed which can provide a guide for the design and optimization of industrial ultrafiltration/diafiltration processes.
Routing lookups in hardware at memory access speeds (2002)

The increased bandwidth in the Internet puts great demands on network routers; for example, to route minimum sized Gigabit Ethernet packets, an IP router must process about 1.5/spl times/10/sup 6/ packets per second per port. Using the "rule-of-thumb" that it takes roughly 1000 packets per second for every 10/sup 6/ bits per second of line rate, an OC-192 line requires 10/spl times/10/sup 6/ routing lookups per second; well above current router capabilities. One limitation of router performance is the route lookup mechanism. IP routing requires that a router perform a longest-prefix-match address lookup for each incoming datagram in order to determine the datagram's next hop. We present a route lookup mechanism that when implemented in a pipelined fashion in hardware, can achieve one route lookup every memory access. With current 50 ns DRAM, this corresponds to approximately 20/spl times/10/sup 6/ packets per second; much faster than current commercially available routing lookup schemes. We also present novel schemes for performing quick updates to the forwarding table in hardware. We demonstrate using real routing update patterns that the routing tables can be updated with negligible overhead to the central processor.
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain. (1982)

The HLA-D locus in the major histocompatibility complex controls the expression of the genetically polymorphic HLA-DR antigens. mRNA coding for the beta chains of these antigens was partially purified from the human lymphoblastoid cell line Raji. The mRNA was copied into double-stranded cDNA and cloned in Escherichia coli. One clone, pDR-beta-1, obtained by hybrid selection, carries a 1070-base-pair insert comprising all of the coding region except the signal sequence and a substantial portion of the untranslated region. To identify pDR-beta-1, highly purified HLA-DR antigen beta chains derived from Raji cells were subjected to NH2-terminal amino acid sequence determination. This sequence displayed extensive homology with that deduced from the nucleotide sequence at the 5' end of the pDR-beta-1 coding region. Taken together, the amino acid and nucleotide sequences strongly argue in favor of Raji cells containing at least two beta-chain loci.
Influence of dimethyl sulfoxide (DMSO) on restoring sensitivity of mycobacterial strains resistant to chemotherapeutic compounds (1979)

Journal Article Influence of dimethyl sulfoxide (DMSO) on restoring sensitivity of mycobacterial strains resistant to chemotherapeutic compounds Get access URSULA MÜLLER, URSULA MÜLLER Research Department, Saarstickstoff Fatol LtdD-6685 Schiffweiler, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar R. URBANCZIK R. URBANCZIK Research Department, Saarstickstoff Fatol LtdD-6685 Schiffweiler, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 5, Issue 3, May 1979, Pages 326–327, https://doi.org/10.1093/jac/5.3.326 Published: 01 May 1979
Advanced Tetracycles in a Stereoselective Approach to d,l-Spongiatriol and Related Metabolites:  The Use of Radicals in the Synthesis of Angular Electrophores (1998)

A stereoselective radical cascade cyclization of polyene 6, containing an α,β-unsaturated cyano group, was employed to control six contiguous chiral centers and to introduce a C-8 angular CN group in tricycle 7. The cyano group was ultimately utilized as an entry to a C-8 angular hydroxymethyl group. Compound 7 was converted into two key tetracycles 22 and 25, respectively, each possessing an intact D-furan ring system and containing the necessary functionality for further chemical elaboration to the highly oxygenated spongians 1-5.
Transform-Limited Pulses Are Not Optimal for Resonant Multiphoton Transitions (2001)

Maximizing nonlinear light-matter interactions is a primary motive for compressing laser pulses to achieve ultrashort transform limited pulses. Here we show how, by appropriately shaping the pulses, resonant multiphoton transitions can be enhanced significantly beyond the level achieved by maximizing the pulse's peak intensity. We demonstrate the counterintuitive nature of this effect with an experiment in a resonant two-photon absorption, in which, by selectively removing certain spectral bands, the peak intensity of the pulse is reduced by a factor of 40, yet the absorption rate is doubled. Furthermore, by suitably designing the spectral phase of the pulse, we increase the absorption rate by a factor of 7.
Molecular Variation in the Variable-Length PCR Target and 120-Kilodalton Antigen Genes ofEhrlichia chaffeensisfrom White-Tailed Deer (Odocoileus virginianus) (2003)

Genes encoding two surface-expressed antigens of Ehrlichia chaffeensis, the variable-length PCR target (VLPT) and the 120-kDa antigen, which contain variable numbers of tandem repeats, were characterized for E. chaffeensis from white-tailed deer (Odocoileus virginianus). Both genes from infected deer contained numbers of repeats similar to those reported in genes from humans and ticks, although a new variant of the 120-kDa antigen gene containing five repeat units and coinfection with multiple VLPT and 120-kDa antigen gene genetic types were detected. Sequence analysis of both genes revealed more nucleotide variation than previously reported for E. chaffeensis from infected humans or ticks. This is the most extensive study of E. chaffeensis VLPT and 120-kDa antigen gene genetic variation to date and is the first to examine genetic variation in E. chaffeensis from a nonhuman vertebrate host.
[Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma]. (2004)

The co-expression of uPA and uPAR was one of the characteristics of urinary transitional cell carcinoma and significantly correlated with tumor stage and grade.
Schizophrenia (maintenance treatment). (2009)

In this systematic review we present information relating to the effectiveness and safety of the following interventions: behavioural therapy, clozapine, cognitive behavioural therapy (CBT), compliance therapy, continuation of antipsychotic drugs (reduce relapse rates), first-generation antipsychotic drugs in treatment-resistant people, multiple-session family interventions, psychoeducational interventions, second-generation antipsychotic drugs in treatment-resistant people, and social-skills training.