gebhart/patrepeval huggingface dataset:
Peptide-Based Cancer Vaccines (2000)

The field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor gro
PREDICTION OF EARLY KIDNEY TRANSPLANT REJECTION BY A CROSSMATCH WITH DONOR SKIN (1989)

Immunofluorescence staining of donor skin with recipient serum was performed in 25 patients undergoing kidney transplantation. Transplants were performed when cytotoxicity T cell crossmatches with long incubation and with antiglobulin enhancement were negative. In 20 patients the skin crossmatch was negative and all had an uneventful course. In 5 other recipients, the crossmatch with skin was positive and all developed severe rejection 1-8 days after transplantation. The correlation between skin crossmatch and early rejection was statistically highly significant (P less than 0.00001). Rejection in the skin-crossmatch-positive group led to graft loss in 3, and chronic rejection with poor residual function in the other 2 patients. Serum creatinine at one month was in the 2.6-5.0 mg/dl range in these two patients, while in the group with negative skin crossmatches 15 had serum creatinine levels of less than 1.6, and 5 were in the 1.6-2.5 mg/dl range. Although the nature of the skin antigen is unknown, it appears that this crossmatch procedure was highly accurate in predicting early kidney transplant rejection.
Electrical properties of (Zr,Sn)TiO4 dielectric thin film prepared by pulsed laser deposition (1996)

We have been successful in obtaining temperature-stable crystallized thin film of (Zr,Sn)TiO4. Preferential (111)-oriented (Zr,Sn)TiO4 thin film was prepared by pulsed laser deposition. Effects of crystallization were elucidated based on a comparison of electric properties of crystallized and amorphous (Zr,Sn)TiO4 film. For crystallized film, the temperature coefficient of capacitance (TCC) was 20 ppm/°C at 3 MHz and the dielectric constant εr=38 in the microwave range of 1–10 GHz. These values are superior to those for amorphous film (TCC=220 ppm/°C, εr=27). The crystallization of this material was found quite effective for improving dielectrical properties. Atomic force microscope images showed the surface morphologies of crystallized and amorphous film of (Zr,Sn)TiO4 to differ.
Dripping to Jetting Transitions in Coflowing Liquid Streams (2007)

A liquid forced through an orifice into an immiscible fluid ultimately breaks into drops due to surface tension. Drop formation can occur right at the orifice in a dripping process. Alternatively, the inner fluid can form a jet, which breaks into drops further downstream. The transition from dripping to jetting is not understood for coflowing fluid streams, unlike the case of drop formation in air. We show that in a coflowing stream this transition can be characterized by a state diagram that depends on the capillary number of the outer fluid and the Weber number of the inner fluid.
PSP‐I/PSP‐II spermadhesin exert a decapacitation effect on highly extended boar spermatozoa (2008)

PSP-I/PSP-II heterodimer is a major protein of boar seminal plasma that is able to preserve, in vitro, the viability, motility and mitochondrial activity of highly-extended boar spermatozoa. However, a relationship between the protective effects of the heterodimer and sperm capacitation is still unclear. The present study investigated the effect of the PSP-I/PSP-II (1.5 mg/mL) on membrane stability, intracellular calcium concentration ([Ca(2+)](I)) and plasma membrane and acrosome integrity of highly extended boar spermatozoa. Boar spermatozoa were diluted to 1 x 10(6) spermatozoa/mL and incubated at 38 degrees C in Phosphate-buffered saline (PBS) for 10, 30, 60, 120 and 300 min or in modified Tris-buffered medium (mTBM) for 10, 20, 30, 60 and 120 min. After each incubation time, the membrane stability (using Merocyanine-540/Yo-Pro-1), elevation of [Ca(2+)](I) (using Fluo-3-AM/PI) and the sperm plasma membrane and acrosome integrity (using SYBR-14/PI/PE-PNA) were evaluated by flow cytometry. As expected, exposure of the spermatozoa to the PSP-I/PSP-II preserved the plasma membrane and acrosome integrity compared to non-exposed spermatozoa in both media PBS and mTBM (p < .01). The evaluation of membrane stability showed no differences in the percentages of viable sperm with instable plasma membrane in the presence of the PSP-I/PSP-II compared to controls irrespective of the dilution media. The evaluation of the [Ca(2+)](I) levels showed that while spermatozoa incubated in mTBM and exposed to PSP-I/PSP-II had lower [Ca(2+)](I) than controls (39.08% vs. 47.97%, respectively; p < .05), no differences were observed in those samples incubated in PBS. However, a temporal evaluation of the samples showed that a similar proportion of live spermatozoa were able to achieve high levels of [Ca(2+)](I) and membrane instability independent of the presence of PSP-I/PSP-II. In conclusion, PSP-I/PSP-II exert a non-permanent decapacitation effect on highly extended boar spermatozoa that is related with a delay in the increase of [Ca(2+)](I) levels.
Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic β-Cell Fate (2006)

Recent studies in normal mice have suggested that transplanted bone marrow cells can transdifferentiate into pancreatic beta-cells at relatively high efficiency. Herein, adopting the same and alternative approaches to deliver and fate map-transplanted bone marrow cells in the pancreas of normal as well as diabetic mice, we further investigated the potential of bone marrow transplantation as an alternative approach for beta-cell replacement. In contrast to previous studies, transplanted bone marrow cells expressing green fluorescence protein (GFP) under the control of the mouse insulin promoter failed to express GFP in the pancreas of normal as well as diabetic mice. Although bone marrow cells expressing GFP under the ubiquitously expressed beta-actin promoter efficiently engrafted the pancreas of normal and hyperglycemic mice, virtually all expressed CD45 and Mac-1/Gr-1, demonstrating that they adopt a hematopoietic rather than beta-cell fate, a finding further substantiated by the complete absence of GFP(+) cells expressing insulin and the beta-cell transcription factors pancreatic duodenal homeobox factor-1 and homeodomain protein. Thus, transplanted bone marrow cells demonstrated little, if any, capacity to adopt a beta-cell fate.
Solid microstructured optical fiber (2003)

An all-solid microstructured fiber based on two thermallymatched silicate glasses with a high index contrast has been fabricated for the first time. The microstructured cladding was shown to be essentially unchanged during fiber drawing. Fiber attenuation was measured as 5dB/m at 1.55m by the cutback method. High nonlinearity 230 W-1km-1 has been predicted and experimentally demonstrated in this fiber at 1.55m. In addition, modeling predicts that near-zero dispersion can be achieved between 1.5-1.6m in this class of high nonlinear fiber.
Ivermectin cream for rosacea (2015)

Rosacea is a chronic facial skin disease that mainly occurs in people aged over 30 years. It is common, with an estimated incidence of 1·7 per 1,000 person-years in general practice in the UK.(1,2) Rosacea can cause embarrassment, anxiety, low self-esteem and lack of confidence.(3) A new topical treatment has become available for the treatment of one of the clinical subtypes of rosacea. Ivermectin 10mg/g (1%) cream (Soolantra-Galderma) has received marketing authorisation for the treatment of inflammatory lesions of papulopustular rosacea in adults.(4) Here we review the safety and effectiveness of ivermectin cream in the treatment of rosacea and assess how it compares with standard therapies.
USING A STATISTICAL LANGUAGE MODEL TO IMPROVE THE PERFORMANCE OF AN HMM-BASED CURSIVE HANDWRITING RECOGNITION SYSTEM (2001)

In this paper, a system for the reading of totally unconstrained handwritten text is presented. The kernel of the system is a hidden Markov model (HMM) for handwriting recognition. This HMM is enhanced by a statistical language model. Thus linguistic knowledge beyond the lexicon level is incorporated in the recognition process. Another novel feature of the system is that the HMM is applied in such a way that the difficult problem of segmenting a line of text into individual words is avoided. A number of experiments with various language models and large vocabularies have been conducted. The language models used in the system were also analytically compared based on their perplexity.
On the Existence of Similar Sublattices (1999)

Abstract Partial answers are given to two questions. When does a lattice Λ contain a sublattice Λʹ of index N that is geometrically similar to Λ? When is the sublattice “clean”, in the sense that the boundaries of the Voronoi cells for Λʹ do not intersect Λ?
CortexSuite: A synthetic brain benchmark suite (2014)

These days, many traditional end-user applications are said to “run fast enough” on existing machines, so the search continues for novel applications that can leverage the new capabilities of our evolving hardware. Foremost of these potential applications are those that are clustered around information processing capabilities that humans have today but are lacking in computers. The fact that brains can perform these computations serves as an existence proof that these applications are realizable. At the same time, we often discover that the human nervous system, with its 80 billion neurons, on some metrics, is more powerful and energy-efficient than today's machines. Both of these aspects make this class of applications a desirable target for an architectural benchmark suite, because there is evidence that these applications are both useful and computationally challenging. This paper details CortexSuite, a Synthetic Brain Benchmark Suite, which seeks to capture this workload. We classify and identify benchmarks within CortexSuite by analogy to the human neural processing function. We use the major lobes of the cerebral cortex as a model for the organization and classification of data processing algorithms. To be clear, our goal is not to emulate the brain at the level of the neuron, but rather to collect together synthetic, man-made algorithms that have similar function and have met with success in the real world. We consulted six world-class machine learning and computer vision researchers, who collectively hold 83,091 citations across their distinct subareas, asking them to identify newly emerging computationally-intensive algorithms or applications that are going to have a large impact over the next ten years. This is coupled with datasets that reflect the philosophy of practical use algorithms and are coded in “clean C” so as to make them accessible, analyzable, and usable for parallel and approximate compiler and architecture researchers alike.
Line Of Sight Stabilization Using Image Motion Compensation (1989)

Image motion compensation (IMC) can be used to augment conventional line-of-sight (LOS) stabilization systems to improve stabilization performance. The tradeoffs involved in deciding when to use IMC and the expected performance improvements are reviewed. Several IMC concepts are outlined including the special case of a gimbaled optical element with a one-to-one scale factor between mechanical and image motion. The advantage of this IMC stabilization approach over other IMC techniques is that performance is not limited by the bandwidth of the sensor or actuator. Performance, however, is limited by optical scale factor accuracies. Precision measurement of the gimbal motion is not required to achieve LOS stabilization. The &quot;restored mass stabilization&quot; approach offers performance improvements without the high cost of precision inertial components.
Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study (2009)

In this study, initial treatment with sitagliptin, metformin, or the combination therapy of sitagliptin and metformin provided substantial and durable glycemic control, improved markers of beta-cell function, and was generally well-tolerated over 54 weeks in patients with type 2 diabetes.
Synthesis and characterization of novel porphyrin Schiff bases (2008)

Novel porphyrin Schiff bases were synthesized by a simple Schiff base condensation in refluxing toluene between 5-(4-aminophenyl)-10,15,20-triphe?nylporphyrin (ATTP) 3 and styryl aldehydes 4-6 or p-halobenzaldehydes 7-9. The newly synthesized porphyrin Schiff bases were characterized on the basis of their chemical properties and spectral data. A good intramolecular energy transfer from the styryl unit to the porphyrin moiety was found.
Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP (1999)

The E2F and DP protein families form heterodimeric transcription factors that play a central role in the expression of cell cycle-regulated genes. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins. The asymmetry in the extended binding site TTTc/gGCGCc/g is associated with an amino-terminal extension of E2F4, in which an arginine binds in the minor groove near the TTT stretch. This arginine is invariant among E2Fs but not present in DPs. E2F4 and DP2 interact through an extensive protein-protein interface, and structural features of this interface suggest it contributes to the preference for heterodimers over homodimers in DNA binding.
Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. (1994)

Transcription of human HOX gene promoters in cultured cells is positively and negatively regulated by HOX proteins interacting with specific target sequences. The human HOXD9 protein activates transcription of the HOXD9 promoter by interacting with the HCR sequence and is antagonized by the HOXD8 protein. HOXD8 is not intrinsically a repressor, since it can activate transcription on different targets. Complete or partial HOXD8/HOXD9 homeo domain swapping indicates that the ability to recognize, and activate transcription from, the HCR target in vivo depends on the amino terminus and helix 1 of the homeo domain. The inhibitory activity of HOXD8 is not affected by deletion of the homeo domain helix 2/3 region, whereas it requires the amino terminus/helix 1 region and an additional, effector domain located at the protein amino-terminal end. This activity is therefore DNA-binding independent, and possibly mediated by protein-protein interactions. Affinity chromatography experiments show that the homeo domain amino terminus/helix 1 region is able to mediate direct interactions between HOX proteins in solution. These data indicate that specificity of HOX protein function in vivo depends on both DNA-protein and protein-protein interactions, mediated by the same sub region of the homeo domain.
Liquid Chromatography/Mass Spectrometry Sequencing Approach for Highly Sulfated Heparin-derived Oligosaccharides (2004)

Liquid chromatography/mass spectrometry (LC/MS) is applied to the analysis of complex mixtures of oligosaccharides obtained through the controlled, heparinase-catalyzed depolymerization of heparin. Reversed-phase ion-pairing chromatography, utilizing a volatile mobile phase, results in the high resolution separation of highly sulfated, heparin-derived oligosaccharides. Simultaneous detection by UV absorbance and electrospray ionization-mass spectrometry (ESI-MS) provides important structural information on the oligosaccharide components of this mixture. Highly sensitive and easily interpretable spectra were obtained through post-column addition of tributylamine in acetonitrile. High resolution mass spectrometry afforded elemental composition of many known and previously unknown heparin-derived oligosaccharides. UV in combination with MS detection led to the identification of oligosaccharides arising from the original non-reducing end (NRE) of the heparin chain. The structural identification of these oligosaccharides provided sequence from a reading frame that begins at the non-reducing terminus of the heparin chain. Interestingly, 16 NRE oligosaccharides are observed, having both an even and an odd number of saccharide residues, most of which are not predicted based on biosynthesis or known pathways of heparin catabolism. Quantification of these NRE oligosaccharides afforded a number-averaged molecular weight consistent with that expected for the pharmaceutical heparin used in this analysis. Molecular ions could be assigned for oligosaccharides as large as a tetradecasaccharide, having a mass of 4625 Da and a net charge of -32. Furthermore, MS detection was demonstrated for oligosaccharides with up to 30 saccharide units having a mass of >10000 Da and a net charge of -60.
Optimizing the stability of single-chain proteins by linker length and composition mutagenesis (1998)

Linker length and composition were varied in libraries of single-chain Arc repressor, resulting in proteins with effective concentrations ranging over six orders of magnitude (10 microM-10 M). Linkers of 11 residues or more were required for biological activity. Equilibrium stability varied substantially with linker length, reaching a maximum for glycine-rich linkers containing 19 residues. The effects of linker length on equilibrium stability arise from significant and sometimes opposing changes in folding and unfolding kinetics. By fixing the linker length at 19 residues and varying the ratio of Ala/Gly or Ser/Gly in a 16-residue-randomized region, the effects of linker flexibility were examined. In these libraries, composition rather than sequence appears to determine stability. Maximum stability in the Ala/Gly library was observed for a protein containing 11 alanines and five glycines in the randomized region of the linker. In the Ser/Gly library, the most stable protein had seven serines and nine glycines in this region. Analysis of folding and unfolding rates suggests that alanine acts largely by accelerating folding, whereas serine acts predominantly to slow unfolding. These results demonstrate an important role for linker design in determining the stability and folding kinetics of single-chain proteins and suggest strategies for optimizing these parameters.
Phase Diagram of Li[sub x](Mn[sub y]Fe[sub 1−y])PO[sub 4] (0≤x, y≤1) (2001)

The room temperature x, y two-dimensional phase diagram of the olivine-type solid-solution, Li x (Mn y Fe 1y )PO 4 (0 x, y 1, orthorhombic, D 2h 16 : Pmnb), is determined. The x-dependent changes in the unit cell dimensions at various fixed Mn contents y are analyzed in detail. The manganese substitution for iron in the octahedral 4c sites induces 1, the two-phase Mn 3 /Mn 2 redox region with a potential of 4.1 V vs. Li/Li ; 2, a partial conversion of the form of the Fe 3 /Fe 2 redox reaction 3.4 V vs. Li/Li ) from two-phase to single-phase; and 3, phase instability at the composition region close to the point x, y 0, 1 caused by the Jahn-Teller effect of Mn 3 . The conversion, 2, is complete at around y 0.6. The phase instability, 3, makes the Mn-rich phase (y 0.8) unsuitable for battery applications. The local lattice deformation around Mn 3 is severe enough to induce significant selective damping in the extended X-ray absorption fine structure for Mn 3 .
The Ly‐49 family: genes, proteins and recognition of class I MHC (1997)

The Ly-49 family consists of at least nine members, of which Ly-49A and C have been found to be NK-cell inhibitory receptors specific for class I MHC. The functions of other Ly-49 molecules are still unclear. Further analysis of Ly-49 is complicated by the cross-reactivities of some anti-Ly-49 antibodies initially thought to be specific for individual Ly-49 molecules. Studies on the role of Ly-49 in hybrid resistance as well as on allelic exclusion are also complicated by our recent finding that a novel Ly-49CB6 gene is the likely allelic form of Ly-49CBALB as opposed to a previously reported highly related but distinct gene in B6 mice. In cell-cell binding assays, only Ly-49A and C show significant binding to class I MHC. Ly-49A and C also bind some polysaccharides, and carbohydrates on class I MHC seem to be important for its binding to Ly-49. However, this interaction involves not only the carbohydrate recognition domain of Ly-49 but also a part of the stalk region, suggesting that both carbohydrates and peptide backbone of class I MHC may be recognized by Ly-49. It is likely that additional Ly-49 molecules yet to be identified function as NK-inhibitory receptors specific for class I MHC.
Infant feeding: a critical look at infant formulas (2000)

Commercially available infant formulas serve as the best alternative to human milk when breastfeeding is not possible. Infant formulas are designed specifically to mimic the composition of human milk or the functional aspects of human milk feeding. This review highlights the issues related to the composition of infant formulas. The most hotly debated issue currently is whether to add long-chain polyunsaturated fatty acids to infant formulas. Other controversial topics include the safety and efficacy of soy-based protein formulas, protein quantity and quality as they relate to the infant's nutritional needs and feeding tolerance, and the replacement of lactose with other carbohydrate sources for specialized infant formulas. Recent modifications in the fat blend of infant formulas have led to improved fat digestibility. However, the full spectrum of benefits associated with the addition of nucleotides awaits further study. Modifications to infant formulas are made when the preponderance of scientific evidence suggests that the compositional change will better meet the nutritional needs of the infant.
No-Go Theorem of Leibniz Rule and Supersymmetry on the Lattice (2008)

An obstacle to realize supersymmetry on a lattice is the breakdown of Leibniz rule. We give a proof of a no-go theorem that it is impossible to construct a lattice field theory in an infinite lattice volume with any nontrivial field products and difference operators that satisfy the following three properties: (i) translation invariance, (ii) locality and (iii) Leibniz rule. We then propose a way to escape from the no-go theorem by introducing infinite flavors, and present a lattice model of N=2 supersymmetric quantum mechanics equipped with the full exact supersymmetry.