gebhart/patrepeval huggingface dataset:
In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299. (2001)

CD26 is a M(r) 110,000 surface glycoprotein with diverse functional properties, including having a potentially significant role in tumor development, and antibodies to CD26 mediate pleomorphic cellular functions. In this report, we show that binding of soluble anti-CD26 monoclonal Ab 1F7 inhibits the growth of the human CD30+ anaplastic large cell T-cell lymphoma cell line Karpas 299 in both in vitro and in vivo experiments. In vitro experiments show that 1F7 induces cell cycle arrest at the G1-S checkpoint, associated with enhanced p21 expression that is dependent on de novo protein synthesis. Furthermore, experiments with a severe combined immunodeficient mouse tumor model demonstrate that 1F7 treatment significantly enhances survival of tumor-bearing mice by inhibiting tumor formation. Our data therefore suggest that anti-CD26 treatment may have potential clinical use for CD26+ hematological malignancies.
MIMO-assisted channel-based authentication in wireless networks (2008)

Multiple-input multiple-output (MIMO) techniques allow for multiplexing and/or diversity gain, and will be widely deployed in future wireless systems. In this paper, we propose a MIMO-assisted channel-based authentication scheme, exploiting current channel estimation mechanisms in MIMO systems to detect spoofing attacks with very low overhead. In this scheme, the use of multiple antennas provides extra dimensions of channel estimation data, and thus leads to a "security gain" over single-input single-output (SISO) systems. We investigate the security gain of MIMO systems in several system configurations via simulations for a specific real indoor environment using ray-tracing software. We also discuss the effect of increasing the number of transmit and receive antennas on the security gain and contrast that to the diversity/multiplexing gain.
Conservative Visibility and Strong Occlusion for Viewspace Partitioning of Densely Occluded Scenes (1998)

Computing the visibility of out‐door scenes is often much harder than of in‐door scenes. A typical urban scene, for example, is densely occluded, and it is effective to precompute its visibility space, since from a given point only a small fraction of the scene is visible. The difficulty is that although the majority of objects are hidden, some parts might be visible at a distance in an arbitrary location, and it is not clear how to detect them quickly. In this paper we present a method to partition the viewspace into cells containing a conservative superset of the visible objects. For a given cell the method tests the visibility of all the objects in the scene. For each object it searches for a strong occluder which guarantees that the object is not visible from any point within the cell. We show analytically that in a densely occluded scene, the vast majority of objects are strongly occluded, and the overhead of using conservative visibility (rather than visibility) is small. These results are further supported by our experimental results. We also analyze the cost of the method and discuss its effectiveness.
C‐erbB‐2 expression and prognostic significance in osteosarcoma (2008)

Overexpression of c-erbB-2 in OST was not correlated with metastatic potential. No independent prognostic significance was detected. The results do not support directed therapies for c-erbB-2 in OST.
Montelukast does not prevent reactive airway disease in young children hospitalized for RSV bronchiolitis (2009)

Treatment with montelukast after hospital admission for RSV bronchiolitis in children younger than 2 years of age did not reduce symptoms of cough and wheeze. We cannot exclude that a subgroup of children may, however, benefit from this treatment.
The Vienna RNA Websuite (2008)

The Vienna RNA Websuite is a comprehensive collection of tools for folding, design and analysis of RNA sequences. It provides a web interface to the most commonly used programs of the Vienna RNA package. Among them, we find folding of single and aligned sequences, prediction of RNA-RNA interactions, and design of sequences with a given structure. Additionally, we provide analysis of folding landscapes using the barriers program and structural RNA alignments using LocARNA. The web server together with software packages for download is freely accessible at http://rna.tbi.univie.ac.at/.
STI571 as a Targeted Therapy for CML (2003)

Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell disorder that progresses through distinct phases as the malignant clone progressively loses the capacity for terminal differentiation. It is characterized by the (9;22) translocation and resultant production of the Bcr-Abl tyrosine kinase. Bcr-Abl functions as a constitutively activated tyrosine kinase, and this kinase activity is absolutely required for the transforming function of the Bcr-Abl protein. In preclinical studies, STI571 (Gleevec, imatinib mesylate), a Bcr-Abl tyrosine kinase inhibitor, specifically inhibited the proliferation of Bcr-Abl-expressing cells in vitro and in vivo. STI571 has shown remarkable results in all phases of CML. Although responses are seen in all phases of the disease, durable responses are most common in earlier stage patients. Thus, STI571 has emerged as a paradigm for gene product targeted therapy, offering expanded treatment options for patients with CML.
Cloning and Characterization of a Complementary DNA Encoding a Human Epididymis-Associated Disintegrin and Metalloprotease 7 Protein1 (2001)

Mammalian spermatozoa interact with the proteins secreted by the epididymis to develop fertility. Transmembrane proteins that possess a disintegrin and metalloprotease (ADAM) domains are shown to be closely related to spermatogenesis and fertilization. Our previous study demonstrated that GP-83, a glycoprotein secreted by the epididymis, was conjugated to mature sperm. In this study, a 2.1-kilobase (kb) GP-83-expressing insert was isolated from a cDNA library of human epididymis by immunoscreening using GP-83-specific antiserum. The 5' end rapid amplification of cDNA ends (RACE) and 3'-RACE of the 2.1-kb insert elucidated two isoforms of GP-83-encoding cDNA sequences, an alpha-form of 3451 base pairs (bp) and beta-form of 2643 bp. Both forms exhibit the same open reading frame of 2262 bp predicting a peptide of 754 amino acid residues. Deduced amino acid sequence revealed signal sequence, prodomain, metalloproteinase, disintegrin, cysteine-rich, epidermal growth factor-like, transmembrane, and cytoplasmic domains. The GP-83-encoding sequence was recognized as human ADAM7 due to significant homology to other ADAM7s. According to the DNA sequences elucidated in the Human Genome Project, h-ADAM7 was located at chromosome 8p22. Ex vivo expression confirmed that h-ADAM7 cDNA did encode GP-83. Northern blot analysis revealed two transcripts of 4 kb and 3 kb in the epididymis, but not in testis or other major tissues. These results indicate that the GP-83-encoding gene is a human epididymis-associated ADAM7 gene (human ADAM7, h-ADAM7) and may be involved in the sperm-egg interaction.
Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98/254 (2006)

In the absence of a suitable carbohydrate-based vaccine, outer membrane vesicle (OMV) vaccines have been used to disrupt outbreaks of serogroup B meningococcal disease for more than 20 years. Proteomic technology provides physical methods with the potential to assess the composition and consistency of these complex vaccines. 2-DE, combined with MS, were used to generate a proteome map of an OMV vaccine, developed to disrupt a long-running outbreak of group B disease in New Zealand. Seventy four spots from the protein map were identified including the outer membrane protein (OMP) antigens: PorA, PorB, RmpM and OpcA. Protein identification indicates that, in addition to OMPs, OMV vaccines contain periplasmic, membrane-associated and cytoplasmic proteins. 2-D-DIGE technology highlighted differences between preclinical development batches of vaccines from two different manufacturers.
Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function (2017)

Cytotoxic T lymphocytes (CTLs) used in immunotherapy are typically cultured under atmospheric O<sub>2</sub> pressure but encounter hypoxic conditions inside tumors. Activating CTLs under hypoxic conditions has been shown to improve their cytotoxicity in vitro, but the mechanism employed and the implications for immunotherapy remain unknown. We activated and cultured OT-I CD8 T cells at either 1% or 20% O<sub>2</sub>. Hypoxic CTLs survived, as well as normoxic ones, in vitro but killed OVA-expressing B16 melanoma cells more efficiently. Hypoxic CTLs contained similar numbers of cytolytic granules and released them as efficiently but packaged more granzyme-B in each granule without producing more perforin. We imaged CTL distribution and motility inside B16-OVA tumors using confocal and intravital 2-photon microscopy and observed no obvious differences. However, mice treated with hypoxic CTLs exhibited better tumor regression and survived longer. Thus, hypoxic CTLs may perform better in tumor immunotherapy because of higher intrinsic cytotoxicity rather than improved migration inside tumors.
Synergistic interactions of various doses of diethylstilbestrol and x-irradiation on mammary neoplasia in female ACI rats. (1980)

Abstract The intent of this study was to investigate the relationship between diethylstilbestrol (DES) dose and its synergistic interaction with X-irradiation for mammary carcinogenesis in ACI rats. In addition, the role of prolactin in this synergism was studied. Ten groups of approximately 25 female ACI rats, 84 to 91 days of age, were implanted s.c. with a compressed 20-mg pellet containing either 5, 1.67, 0.56, 0.19, or 0 mg of DES combined with cholesterol. Two days later, one group at each dose level was exposed (whole body) to 150 R of 250 kVp X-radiation. Plasma prolactin levels were determined by radioimmunoassay on samples taken at approximately 100-day intervals. The experiment was terminated 659 days after pellet implantation. Three basic types of mammary neoplasms were found: individual mammary adenocarcinoma (MAC); multiple mammary adenocarcinoma (MMAC) consisting of four or more MAC9s within a single quadrant of breast tissue; and mammary fibroadenoma. Increasing the dose of DES (with or without irradiation) increased the number of rats with a MAC (incidence) and the number of MAC9s per rat while also decreasing the mean time of appearance of all MAC9s. MMAC9s were found only in rats treated with the two highest doses of DES (with or without irradiation), and this response appeared to be DES dose dependent. Combining irradiation with DES treatment (except at the lowest DES dose) produced a synergistic increase in the MAC and MMAC incidence and the number of MAC9s and MMAC9s per rat and decreased the time of appearance of all MAC9s. Rats receiving only X-irradiation had only a few late-appearing MAC9s. No MAC9s were seen in the cholesterol control group. Fibroadenomas were very late-occurring tumors, and their time of appearance did not appear to be DES dose dependent (with or without irradiation). Almost all the rats in the three highest-dose groups had pituitary tumors, while in all other groups only about one-half of the animals had these tumors. There appeared to be a definite relationship between the dose of DES and both the initiation and the degree of plasma prolactin elevation for all DES doses except the lowest. These data suggest that in female ACI rats, MAC induction by DES alone or by the synergistic interaction of DES and X-irradiation is highly DES dose dependent. This DES dose dependence appears to be mediated via an estrogenic stimulation of prolactin secretion, since the higher and the earlier that prolactin was elevated the greater were the MAC and MMAC responses.
Sapphyrins: novel aromatic pentapyrrolic macrocycles (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSapphyrins: novel aromatic pentapyrrolic macrocyclesVictor J. Bauer, Derrick L. J. Clive, David Dolphin, John B. Paine III, Francis L. Harris, Michael M. King, John Loder, Shen Wei Chien Wang, and Robert Burns WoodwardCite this: J. Am. Chem. Soc. 1983, 105, 21, 6429–6436Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/ja00359a012https://doi.org/10.1021/ja00359a012research-articleACS PublicationsRequest reuse permissionsArticle Views1917Altmetric-Citations253LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Effect of superoxide dismutase on experimental allergic uveitis]. (1993)

In this study, experimental allergic uveitis (EAU) in guinea pigs was induced by an injection of bovine serum albumin (BSA) into the vitreous after having pre-immunized them intradermally with BSA plus incomplete Freund adjuvant, and the effect of superoxide dismutase (SOD) on EAU was observed. The result showed that, histopathologically, the phlogistic cell infiltration and exudation within the anterior ocular part of the SOD- treated animals reduced notably. It is suggested that SOD which can scavenge the free radical superoxide anion may alleviate the cellular reaction in the pathological process of uveitis.
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes (2002)

Hematopoietic progenitor kinase 1 (HPK1) is a member of germinal center kinases that is predominantly expressed in hematopoietic cells and transiently activated by T-cell receptor (TCR) triggering. We show here that HPK1 supports apoptosis of T cells. When HPK1 was overexpressed in murine CD4(+) T cells, a substantial increase was observed in spontaneous and TCR/CD3-mediated apoptosis as well as in Fas ligand (FasL) expression. In H2O2-treated EL-4 thymoma cells, which show an increase in reactive oxygen species (ROS) and apoptosis, overexpression of HPK1 enhanced ROS-mediated apoptosis, whereas expression of HPK1 antisense (AS) RNA impaired apoptosis. HPK1 expression also led to a sustained increase in c-Jun N-terminal kinase (JNK) activity, suggesting that JNK activation contributes to the HPK1-mediated apoptosis in H2O2-treated EL-4 cells. Under the same conditions, a rapid cleavage of HPK1 was observed, and overexpression of N- and C-terminal cleavage products in CD4(+) T cells resulted in, similar to full-length HPK1, an increase in apoptosis. In agreement with published data, we show that the C-terminal portion of HPK1 suppresses IkappaBalpha degradation, thereby inhibiting nuclear factor (NF)-kappaB activation. These findings suggest that by inhibiting the antiapoptotic action of NF-kappaB and inducing the proapoptotic activity of JNK, OHPK1 supports apoptosis in T cells.
A detailed examination of the antibody prevalence and characteristics of anti-ESA antibodies (2012)

A low prevalence of non-neutralizing anti-ESA IgM specific to glycosylation on the ESA and IgG1 antibodies specific to the ESA protein was detected across all clinical patient populations. Patients with amPRCA were noted to have high IgG antibody concentrations, neutralizing antibodies and the presence of anti-ESA IgG4 antibodies.
Activation and Repression of the Activity of a Lead Ribozyme by the Combination of Pb2+ and Mg2+ (1997)

The effect of Pb2+ and Mg2+ on the activity of a lead ribozyme with modified sequences has been studied. At low Pb2+ concentrations, cleavage at a previously reported site (site a) is observed. At higher Pb2+ concentrations, cleavage at a new site (site b) adjacent to site a is observed, while the cleavage at site a is repressed. On the addition of a certain amount of Mg2+, the cleavage at site a is enhanced by almost fourfold, while the cleavage at site b is repressed. Further addition of Mg2+ represses the cleavage at both sites. CD analysis indicates that the structure and stability of the lead ribozyme change depending on the metal conditions. Activation and repression of the activity by the combination of Pb2+ and Mg2+ are rationalized by considering that the two metals compete with each other for binding at two metal-binding sites.
Hybrid macroporous materials for heavy metal ion adsorption (2002)

Hybrid macroporous materials with thiol functional groups attached to titania and zirconia frameworks have been prepared via colloidal crystal templating techniques for use as heavy metal ion adsorbents. Synthesis procedures are described for the preparation of thiol–metal oxide materials containing either siloxane or sulfonate linkages. The hybrid macroporous materials were characterized by SEM, FT-IR, 29Si MAS NMR, elemental analysis, and nitrogen adsorption. The materials contained high levels of chemically anchored thiol groups and had uniform porous structures. The hybrid macroporous materials were effective adsorbents for the removal of heavy metal ions from solution, with adsorption capacities ranging from 0.33 to 1.41 mmol g−1 for mercury(II) ions and 0.27 to 1.24 mmol g−1 for lead(II) ions. The hybrid materials remained effective for metal ion adsorption after regeneration by an acid wash, with metal ion loading capacities of the recycled materials being on average two-thirds that of the original capacities. The metal ion adsorption capacity and reusability of hybrid macroporous materials makes them promising adsorbents for wastewater cleanup.
Multiple-wavelength vertical-cavity surface-emitting laser arrays (1997)

Multiple-wavelength vertical-cavity surface-emitting InGaAs QW laser (MW-VCSEL) arrays are fabricated using two patterned-substrate growth techniques both in conjunction with a location-resolvable in situ laser reflectometer in a molecular beam epitaxy (MBE) system. A backside pattern on the substrate is used to induce a temperature profile on the growth surface. In the first technique, we used a temperature-dependent growth rate to create MW-VCSEL's, whereas for the second, uniform growth was first performed followed by a temperature-dependent redesorption process to create the thickness gradient required for MW-VCSEL's. We achieved a record wavelength span, accurate and repeatable lasing wavelengths, and reproducible multiple-wavelength VCSEL arrays with high performance. Comparison between the two methods will be discussed.
Chiral (salen)Co(III) catalyst for the synthesis of cyclic carbonates. (2004)

A catalyst system comprised of a Co(III)(salen) complex and a Lewis base is investigated for the reaction of CO2 and a variety of epoxides to form cyclic carbonates. Application of this catalyst system in the kinetic resolution of propylene oxide is also discussed.
Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex (2008)

The potential of ligand-based design of antagonists of urinary tract infections is ruled by the structural mimicry of natural epitopes and extends into blocking of bacterial invasion, intracellular growth and capacity to fluxing and of recurrence of the infection.
[Thermophilic Myceliophthora thermophila decomposes cellulose]. (1984)

A thermophilic microscopic fungus was isolated from cattle rumen and identified as Myceliophthora thermophila (Apinis) van Oorschot. The culture synthesized cellulolytic enzymes and xylanase when it was grown in media containing cellulase at 50 degrees C under the conditions of submerged cultivation. The morphological and physiological characteristics of the culture are described and its taxonomic position is discussed.
The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. (2002)

Wild-type and mu-opioid receptor knockout (MORKO) mice were used to investigate the role of corticosterone (CORT) and the mu-opioid receptor (MOR) in chronic morphine-mediated immunosuppression. We found that although plasma CORT concentrations in CORT infusion (10 mg/kg/day) and morphine-pellet implantation (75 mg) mice were similar (400-450 ng/ml), chronic morphine treatment resulted in a significantly higher (two- to threefold) inhibition of thymic, splenic, and lymph node cellularity; inhibition of thymic-lymphocyte proliferation; inhibition of IL-2 synthesis; and activation of macrophage nitric oxide (NO) production when compared with CORT infusion. In addition, results show that the inhibition of IFN-gamma synthesis and splenic- and lymph node-lymphocyte proliferation and activation of macrophage TNF-alpha and IL-1beta synthesis occurred only with chronic morphine treatment but not with CORT infusion. These morphine effects were abolished in MORKO mice. The role of the sympathetic nervous system on morphine-mediated effects was investigated by using the ganglionic blocker chlorisondamine. Our results show that chlorisondamine was able to only partially reverse morphine's inhibitory effects. The results clearly show that morphine-induced immunosuppression is mediated by the MOR and that although some functions are amplified in the presence of CORT or sympathetic activation, the inhibition of IFN-gamma synthesis and activation of macrophage-cytokine synthesis is CORT-independent and only partially dependent on sympathetic activation.
Les archives contemporaines : problèmes juridiques et pratiques de communication en République fédérale d'Allemagne (1985)

Il n'y a pas en RFA ― a la difference de la France ― de direction centrale ni de reglementation uniforme en matiere d'archives: elles sont sous la responsabilite des Lander. D'autre part, il n'y a pas encore de veritable reglementation pour l'organisation et l'utilisation des archives; un projet de loi sur la sauvegarde et l'utilisation des archives federales a ete soumis au Parlement de Bonn en aout 1984
Self-assembled monolayer as an antiadhesion layer on a nickel nanostamper in the nanoreplication process for optoelectronic applications (2006)

In this letter, self-assembled monolayer (SAM) was applied as an antiadhesion layer in the nanoreplication process to reduce the surface energy between the nanostamper and the polymeric nanopatterns. After electrochemical pretreatment process, n-dodecanethiol SAM was deposited on the nickel stamper using the solution deposition method. To examine the feasibility of the SAM as an antiadhesion layer, contact angle and lateral friction force were measured at room temperature. To verify the effectiveness of SAM for nanoreplication process, polymeric patterns were replicated by hot-embossing process using SAM-deposited nickel stamper. To apply our method to replication of sub-100-nm-scale nanopillar arrays, the nanopatterned substrate with nanopillar arrays was replicated using nanoinjection molding process with SAM-deposited nickel stamper.