gebhart/patrepeval huggingface dataset:
Wi-Fi for the Enterprise: Maximizing 802.11 For Business (2003)

From the Publisher:
PUT WiFi TO WORK

With his potent gift for clearly explaining technology, networking guru/author Nathan J. Muller presents a powerful set of tools for making the right decisions, the best moves, and extracting maximum benefits from WiFi in the workplace. In WiFi for the Enterprise, he shares his expertise on equipment, configurations, and features for business environments.

WiFi-WHAT, WHY, AND HOW

If you're among the 44% of businesses planning on integrating WiFi, you've found the best source for solutions. WiFi for the Enterprise helps network managers, integrators, and other interested parties drill down to- * Authoritative and readable answers, without wading through engineeringese 

Business-boosting potentials of different flavors of WiFi Choices in product classes that yield performance, security, and scalability Coping strategies for a market that features more than 300 certified WiFi products Interoperability solutions for WiFi integration with technology you already run Design, configuration, and security answers for your WiFi network WiFi network troubleshooting, monitoring, and management strategies Selecting a WiFi service provider for Internet access

DYNAMIC, WORKING ANSWERS ON THE MOST EXCITING DEVELOPMENT IN NETWORKING


The suite of WiFi standards has solidified this year and no license is required for setting up a WiFi network. From the technical standpoint, it's easy and cheap to install one in your corporate network. Already there are over 300 (and climbing) WiFi certified products on the market. Expansion into the enterprise is proceeding at a rapid pace, with the market projected at $1 billion by year-end 2002. Despite the simplicity of the technology, IT is discovering that numerous problems accompany a WiFi integration project, not the least of which is security. This book is designed to drill down to the practical aspects of building the network to interoperate with the technology your company has already deployed.
Semi-synthesis of triterpene A-ring derivatives from oleanolic and maslinic acids. Part II. Theoretical and experimental 13C chemical shifts† (2000)

Maslinic acid was obtained from olive-pressing residues, and several derivatives were formed. Rearrangements of 2-tosyloxy-derivatives of methyl maslinate made out by acetolysis. The main product of these rearrangements contained a cyclopentanic A-ring as a result of a concerted 2(3) → 4-abeo rearrangement process. Experimental and theoretical (GIAO, B3LYP/6-31G * //MM+) 13 C NMR chemical shifts for 20 compounds are given.
Insulin Glulisine: An Evaluation of Its Pharmacodynamic Properties and Clinical Application (2009)

Insulin glulisine is a safe and effective rapid-acting insulin analog for the treatment of adults with diabetes. Clinical benefit over other short- and rapid-acting insulin products is not established. Addition of insulin glulisine to a formulary should be based on institution-specific availability and cost differences between glulisine, lispro, and aspart in the absence of superiority of clinical efficacy or safety and data beyond 26 weeks.
Properties of 2'-fluorothymidine-containing oligonucleotides: interaction with restriction endonuclease EcoRV (1991)

2'-Fluorothymidine (Tf) was synthesized via an improved procedure with (diethylamino)sulfur trifluoride. The compatibility of the analogue with DNA synthesis via the phosphoramidite method was demonstrated after complete enzymatic digestion of the oligonucleotides d(Tf11T) and d(Tf3T), the sole products of which were 2'-fluorothymidine and thymidine in the expected ratio. The 2'-fluorothymidine was also incorporated into the EcoRV recognition sequence (underlined), within the complementary oligonucleotides d(CAAACCGATATCGTTGTG) and d(CACAACGATATCGGTTTG). Thermal melting characteristics of these duplexes showed a significant decrease in stability only when both of the thymidine residues in one of the strands were replaced. In contrast, when all of one strand of a duplex contained 2'-fluorothymidine, as in d(Tf11T).d(A12), a substantially higher Tm and cooperativity of melting was observed relative to the unmodified structure. EcoRV cleaved a duplex that contained a 2'-fluorothymidine at the scissile linkage in each strand at two-thirds of the rate obtained for the unmodified structure. A duplex containing two 2'-fluorothymidine residues in one strand and none in the other was cleaved at one-third of the rate in its unsubstituted strand, whereas the cleavage rate was reduced to 22% in its modified strand.
Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. (1990)

We have isolated from B16 mouse melanoma cells a complementary DNA (Mel-18), whose deduced amino acid sequence possesses a characteristic zinc finger structure. Immunostaining with antibodies raised against partial Mel-18 peptide sequences demonstrated nuclear localization of the gene product. We have also demonstrated that this protein has DNA-binding capacity, and the zinc finger is responsible for the DNA binding. At the transcriptional level the Mel-18 mRNA was detected in all tumor cells examined as well as melanoma cells (ontogenically of neural origin) but was scarcely present in normal tissues except neural organs. The transcript is developmentally regulated. These data suggest that Mel-18 may play a role in transcriptional regulation and also in control of cell proliferation and/or neural cell development.
ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression (2012)

The ATP-binding cassette family of transporter proteins, subfamily B (MDR/TAP), member 1 (ABCB1) (P-glycoprotein) transporter is a key component of the blood-brain barrier. Many antidepressants are subject to ABCB1 efflux. Functional polymorphisms of ABCB1 may influence central nervous system bioavailability of antidepressants subject to efflux. Single-nucleotide polymorphisms (SNPs) at rs1045642 (C3435T) of ABCB1 have been associated with efflux pump efficiency. This may explain part of the interindividual variation in antidepressant dose needed to remit. Individuals (N=113) with DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) major depressive disorder (MDD) were treated with escitalopram (ESC) or venlafaxine (VEN) over 8 weeks. The17-item Hamilton Depression Rating Scale was assessed serially, blind to genotype. SNP rs1045642 of ABCB1 along with two SNPs previously reported to be in linkage disequilibrium with it (rs2032582 and rs1128503) were genotyped. Demographic features, clinical features, P450 metabolizer status and 5-HTTLPR (serotonin-transporter-linked promoter region) genotype were controlled for. Carriers of rs1045642 TT needed on average 11 mg of ESC to remit, whereas TC and CC carriers required 24 and 19 mg, respectively (P=0.0001). This equates to a 2.0- (95% confidence interval=1.5-3.4; P<0.001) fold greater ESC dose needed to remit for C carriers compared with TT carriers at rs1045642. Of VEN-treated subjects carrying TT genotype at rs1045642, 73.3% remitted compared with 12.5% for CC genotype (odds ratio=6.69; 95% confidence interval=1.72-25.9, P=0.006). These data suggest that antidepressant dose needed to remit can be predicted by an ABCB1 SNP. This has the potential clinical translation implications for dose selection and remission from MDD.
Quantification of glucose transport and phosphorylation in human skeletal muscle using FDG PET. (1999)

We demonstrate by computer simulations that a three-compartment model can be used to characterize the first two steps of glucose metabolism in skeletal muscle. An optimized measurement protocol is developed and applied to experimental data. This experimental approach should be appropriate to test whether glucose transport or hexokinase activity is altered in disorders of muscular glucose utilization.
Tetrabenazine therapy of dystonia, chorea, tics, and other dyskinesias (1988)

Dopamine receptor blocking drugs, commonly used in the treatment of involuntary movements, may cause potentially serious adverse effects, including tardive dyskinesia. Tardive dyskinesia has not been reported with tetrabenazine, a dopamine-depleting drug. We report a follow-up in 217 patients treated with tetrabenazine for about 18 months (range, 1 to 80). The response was rated on a scale of 0 to 5 (1 = marked improvement, 4 = no response, 5 = worsening). The mean effect from tetrabenazine was rated as follows: 2.3 in 44 patients with tardive dyskinesia, 2.6 in 15 with tardive dystonia, 2.6 in 10 with Huntington's disease, 2.7 in 17 with Gilles de la Tourette's syndrome, 2.8 in 19 with generalized dystonia, 2.8 in 57 with Meige's syndrome, and 3.4 in 25 with other focal dystonias. Twenty-two patients with a variety of unusual movement disorders had a mean effect of 2.9. Parkinsonism occurred as a side effect in 53 patients, sedation in 28, depression in 23, anxiety in 16, insomnia in 11, and akathisia in 10. The choreatic movement disorders are most amenable to tetrabenazine therapy, but tardive and idiopathic dystonia may also be responsive. Tetrabenazine is an effective and relatively safe drug for a variety of hyperkinetic movement disorders.
A MEMS-based fully-integrated wireless neurostimulator (2010)

We report design, fabrication and in-vivo animal testing of a MEMS-based wireless battery-free compact (3.1 × 1.5 × 0.3 mm) neurostimulator for the treatment of chronic pain. The neurostimulator consists of a spiral coil for inductive power coupling, Schottky diodes for rectification, an ASIC neurostimulator circuit chip, and biphasic platinum-iridium (PtIr) stimulation electrodes. The device is fully integrated and completely embedded in biocompatible SU-8 packaging. The wireless neurostimulator was implanted subcutaneously in a rat hind limb and stable and robust cortical responses during extended periods of wireless stimulation with as low as 21 dBm (125 mW) RF power at 394 MHz were recorded.
Tumor Therapy with Targeted Atomic Nanogenerators (2001)

A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.
Clean Photodecomposition of 1-Methyl-4-phenyl-1H-tetrazole-5(4H)-thiones to Carbodiimides Proceeds via a Biradical (2010)

The photochemistry of 1-methyl-4-phenyl-1H-tetrazole-5(4H)-thione (1a) and 1-(3-methoxyphenyl)-4-methyl-1H-tetrazole-5(4H)-thione (1b) was studied in acetonitrile at 254 and 300 nm, which involves expulsion of dinitrogen and sulfur to form the respective carbodiimides 5a,b as sole photoproducts. Photolysis of the title compounds in the presence of 1,4-cyclohexadiene trap led to the formation of respective thioureas, providing strong evidence for the intermediacy of a 1,3-biradical formed by the loss of dinitrogen. In contrast, a trapping experiment with cyclohexene provided no evidence to support an alternative pathway of photodecomposition involving initial desulfurization followed by loss of dinitrogen via the intermediacy of a carbene. Triplet sensitization and triplet quenching studies argue against the involvement of a triplet excited state. While the quantum yields for the formation of the carbodiimides 5a,b were modest and showed little change on going from a C(6)H(5) (1a) to mOMeC(6)H(4) (1b) substituent on the tetrazolethione ring, the highly clean photodecomposition of these compounds to a photostable end product makes them promising lead structures for industrial, agricultural, and medicinal applications.
Cloning, nucleotide sequencing, and expression of an opine dehydrogenase gene from Arthrobacter sp. strain 1C (1995)

The gene coding for opine dehydrogenase from Arthrobacter sp. strain 1C was cloned onto plasmid pBluescript KS(-), and the nucleotide sequence of the 1,077-bp open reading frame consisting of 359 codons was identified as the odh gene. Transformed Escherichia coli cells overproduced NAD+-dependent opine dehydrogenase under control of the promoter of the lac gene on pBluescript KS(-).
Energetic aspects of glucose metabolism in a pyruvate-dehydrogenase-negative mutant of Saccharomyces cerevisiae (1994)

Saccharomyces cerevisiae T23C (pda1::Tn5ble) is an isogenic gene replacement mutant of the wild-type strain S. cerevisiae T23D. The mutation causes a complete loss of pyruvate dehydrogenase activity. Pyruvate metabolism in this pyruvate-dehydrogenase-negative (Pdh-) strain was investigated in aerobic glucose-limited chemostat cultures, grown at a dilution rate of 0.10 h-1, and compared with the metabolism in the isogenic wild-type strain. Under these conditions, growth of the Pdh- strain was fully respiratory. Enzyme activities in cell-free extracts indicated that the enzymes pyruvate decarboxylase, acetaldehyde dehydrogenase and acetyl-coenzyme A (acetyl-CoA) synthetase could provide a functional bypass of the pyruvate dehydrogenase complex. Since this metabolic sequence involves ATP hydrolysis in the acetyl-CoA synthetase reaction, a negative effect of the pda1::Tn5ble mutation on the growth efficiency was anticipated. Indeed, the biomass yield of the Pdh- strain [0.44 g biomass (g glucose)-1] was significantly lower than that of wild-type S. cerevisiae [0.52 g biomass (g glucose)-1]. The effect of the mutation on biomass yield could be quantitatively explained in terms of a lower ATP yield from glucose catabolism and an increased ATP requirement for the synthesis of acetyl-CoA used in anabolism. Control experiments showed that the pda1::Tn5ble mutation did not affect biomass yield in ethanol-limited chemostat cultures. The results support the view that, during aerobic glucose-limited growth of S. cerevisiae at low growth rates, the pyruvate dehydrogenase complex accounts for the major part of the pyruvate flux. Moreover, it is concluded that hydrolysis of pyrophosphate formed in the acetyl-CoA synthetase reaction does not contribute significantly to energy transduction in this yeast. Respiratory-deficient cells did not contribute to glucose metabolism in the chemostat cultures and were probably formed upon plating.
Juvenile Hormone: Activity of Natural and Synthetic Synergists (1968)

A group of nonsesquiterpenoid compounds currently used commercially as insecticide synergists possesses a high order of juvenile hormone activity and species specificity.
[Utilization of cortisol and corticosterone by the tissue in thermal burns]. (1977)

Clinico-experimental studies were made of the level of cortizol and corticosterone in the tissue fluid of burn vesicles and the blood plasma flowing from the burned and intact body areas; the character and the extent of entrance into the tissues and utilization by them of these hormones was assessed. Along with the increase in the blood cortizol and corticosterone concentrations, and, particularly, in the exudate of the burn vesicles the burned humans and rabbits displayed a different dynamics of the changes in the hormone level in the biological media under study. In the patients and the experimental animals cortizol content in the burn exudate was several times greater than corticosterone concentration. Cortizol level in the edema fluid directly correlated with the degree of edema. It appeared that the burned tissues had a different capacity to the uptake and utilization of cortizol and corticosterone. Features of similarity and differences were noted in the dynamics of the hormonal shifts in the sick and experimental animals. In difference from the intact animals, in the burned rabbits the corticosterone type of the adrenal secretion changed to preponderantly cortizol one.
Method and device for bio-impedance measurement with hard-tissue applications (2008)

Bio-impedance measurements can be used to detect and monitor several properties of living hard-tissues, some of which include bone mineral density, bone fracture healing or dental caries detection. In this paper a simple method and hardware architecture for hard tissue bio-impedance measurement is proposed. The key design aspects of such architecture are discussed and a commercial handheld ac impedance device is presented that is fully certified to international medical standards. It includes a 4-channel multiplexer and is capable of measuring impedances from 10 kOmega to 10 MOmega across a frequency range of 100 Hz to 100 kHz with a maximum error of 5%. The device incorporates several user interface methods and a Bluetooth link for bi-directional wireless data transfer. Low-power design techniques have been implemented, ensuring the device exceeds 8 h of continuous use. Finally, bench test results using dummy cells consisting of parallel connected resistors and capacitors, from 10 kOmega to 10 MOmega and from 20 pF to 100 pF, are discussed.
Tumor Necrosis Factor (1998)

The pace at which connections are being drawn between the nervous system and the immune system does not appear to be slowing. Although the relationship between these two systems is more commonly discussed in terms of concrete interactions modulating physiology, it can be expanded to include more abstract considerations, such as analogies between molecules and between basic principles of operation. Thus, we have come to see beyond the responsiveness of leukocytes to neuropeptides and neuromodulators like CRH and morphine, to recognize relationships exemplified by the compatibility between the principles of antigen presentation and Hebbian arguments about associative synaptic plasticity. Similarly, one can argue that innoculation is a form of conditioning and that neurons may be conditioned not only to strengthen a circuit required for information storage, but that they may also be conditioned to withstand greater metabolic demands or injurious conditions. The central nervous system (CNS) certainly maintains a degree of immune privilege; therefore, one must consider the role of resident leukocytes (i.e., microglia). That they help to combat infections is obvious, but microglia also respond to noninfectious pathologies with reactions more complex than the staid phagocytosis of debris; it is difficult to imagine that retention of the latter responses by evolution is accidental. This chapter focuses on a specific component of gliotic mediators, tumor necrosis factor (TNF). Some of the data discussed distinguishes between TNFα (cachectin) and TNFβ (lymphotoxin-α). However, their mechanisms of action and the responses of relevant target cells are similar enough that the more inclusive TNFs or TNF- will be used often to describe these shared actions. Emphasis is given to the role of TNFs in brain injury responses and to data that force consideration of the possibility that TNF expression in the CNS may have beneficial influences, particularly with respect to conditioning that enhances neuronal resistance to insults.
Cross-resistance to the transplantation of syngeneic Friend, Moloney, and Rauscher virus-induced tumors. (1968)

Summary Immunofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation studies. To determine if tumors induced by FMR and Gross virus share transplantation antigens, C57BL/6 mice were pretreated with either infectious FMR viruses, FMR lymphomas, or a Gross lymphoma and challenged with syngeneic FMR and Gross lymphomas. Mice pretreated with any one infectious FMR virus or its induced lymphoma became resistant to the transplantation of all FMR lymphomas, but not to the Gross lymphoma. Immunization with the Gross lymphoma failed to induce resistance to the transplantation of the FMR lymphomas, but also failed to induce resistance to itself. The results strongly suggest that FMR lymphomas possess related or identical transplantation antigens.
A Role for Hydration in Interleukin‐2 Inducible T Cell Kinase (Itk) Selectivity (2011)

The selectivity profile of kinase inhibitors is commonly explained in terms of favourable or unfavourable interactions between the inhibitor and active site residues. In practice residue sequence differences have not always been sufficient to explain observed selectivity profiles. A series of interleukin-2 inducible T cell kinase (Itk, EC 2.7.10.2) inhibitors that achieve selectivity through the introduction of a single nitrogen atom in an aromatic ring has recently been discovered. Structures of these inhibitors bound to Itk showed this nitrogen to be solvent exposed and not involved in any direct interactions with the enzyme. By analysing active site hydration, using the molecular dynamics tool WaterMap, the observed selectivity profile can be explained in terms of the replacement of a thermodynamically unfavourable water molecule by the inhibitor and improved hydration of the bound ligand. The location of this hydration site was successfully used to enrich virtual screening results in their content of selective Itk inhibitors.
Colorimetric Detection of PNA-DNA Hybridization Using Cyanine Dyes (2003)

The high affinity and sequence selectivity with which peptide nucleic acid (PNA)oligomers bind to complementary DNA and RNA makes them attractive hybridization probes for diagnostics. As is the case for all detection schemes, some type of signaling event is required in order to demonstrate successful hybridization. This chapter focuses on optical detection methods, although electrochemical (1)and surface plasmon resonance (2)methods have also been reported. Optical methods are of advantage because of the realtime monitoring capability in standard techniques, such as polymerase chain reaction (PCR), as well as the potential for use in vivo in conjunction with fluorescence microscopy.