gebhart/patrepeval huggingface dataset:
Alternative drug formulations of docetaxel: a review (2006)

The anticancer drug docetaxel (Taxotere) is formulated in the nonionic surfactant polysorbate 80 (Tween 80). Early in the clinical development of docetaxel, it became clear that docetaxel administration is associated with the occurrence of unpredictable (acute) hypersensitivity reactions and cumulative fluid retention. These side-effects have been attributed, in part, to the presence of polysorbate 80 and have consequently initiated research focused on the development of a less-toxic, better-tolerated polysorbate 80-free formulation of docetaxel. More recently, there is an increasing interest in developing a (polysorbate 80-free) docetaxel formulation that selectively targets malignant tissue, thereby increasing efficacy while decreasing the occurrence of side-effects related to wide and nonspecific body distribution. This review aims to discuss the preclinical and clinical results of pharmaceutical strategies [PEGylated (immuno)liposomal docetaxel, docetaxel-fibrinogen-coated olive oil droplets, docetaxel encapsulated nanoparticle-aptamer bioconjugates, submicronic dispersion formulation] to develop an alternative, solvent-free, delivery form for docetaxel characterized by increased efficacy and decreased toxicity.
Prevalence and Predictors of Asymptomatic Liver Disease in Patients Undergoing Gastric Bypass Surgery (2003)

Moderate to severe hepatic steatosis and NASH are common among individuals undergoing gastric bypass procedures. Diabetes mellitus but not BMI is associated with NASH and advanced hepatic fibrosis in these patients.
TGF-β and Related Cytokines in Inflammation (2001)

This volume is a comprehensive review of the structure/function and biology of molecules belonging to the TGF-[beta] superfamily. Because molecules in this family have very diverse biological roles, the editors have chosen to focus on the parts they play in the specific areas of inflammation and wound/fracture healing. Whilst molecules in the TGF-[beta] superfamily have been extensively studied, there are few, if any, publications which have taken a broad perspective on this family, most having chosen to focus on just one very small area. This book is therefore unusual in that it offers a comprehensive overview of the current state of the field, providing both in-depth and essential background material suitable for both clinicians and scientists alike.
Improved Dynamic Multimedia Resource Adaptation-based Peer-to-Peer System through Locality-based Clustering and Service (2005)

A dynamic P2P architecture based on MPEG-21 was proposed in our previous work to support resource adaptation/personalization according to the surrounding usage environment and user preferences. In this paper, we improve the proposed system through two separate but related modifications. Firstly, peers are clustered according to registered geographic location information. Secondly, based on that registered location information, a locality-based service is introduced which allows users to search services according to their geographic locations. The service complements the proposed P2P architecture by encouraging service providers to increase the uptime of their devices and hence provide the spare computer power for active adaptation of resources for low-end peers. Simulation results show that the proposed approach reduces download time and network delays while increasing resource availability and download speed in the network.
MECHANISMS OF ACQUIRED RESISTANCE IN MOUSE TYPHOID (1966)

Experiments in vitro comparing normal mouse peritoneal macrophages with cells from Salmonella typhimurium-infected mice have shown that the "immune" macrophages have conspicuously enhanced microbicidal properties. Whereas normal macrophages could inactivate only 50 to 60% of intracellular S. typhimurium pretreated with immune serum, cells from infected animals killed virtually all ingested organisms and did so at an accelerated rate. Macrophages from Listeria monocytogenes-infected mice were shown to possess similarly enhanced microbicidal activity against S. typhimurium. Furthermore, the growth of S. typhimurium in the liver and spleen was more effectively restricted in Listeria-infected mice than in animals vaccinated with heat-killed S. typhimurium, even though the Listeria-infected animals possessed no demonstrable cross-reacting antibody to S. typhimurium. The lack of resistance in the mice vaccinated with heat-killed organisms could not be attributed to any deficiency of humoral factors, since the serum from these animals was as effective at promoting phagocytosis and killing by macrophages as serum from actively infected (and demonstrably resistant) mice. Conversely, Salmonella-infected mice were totally resistant to intravenous challenge with L. monocytogenes. The level of resistance in individual animals was related to the numbers of residual Salmonellae remaining in the tissues; mice with heavier residual infections being the more resistant. Specific antiserum from mice vaccinated with heat-killed S. typhimurium was found to be significantly protective only when the intraperitoneal route of challenge was employed. The foregoing studies have been interpreted to mean that enhancement of the microbicidal ability of macrophages is the mechanism of major importance in acquired resistance to S. typhimurium infection in mice.
Considerations with the use of biological therapy in the treatment of rheumatoid arthritis (2004)

The treatment of rheumatoid arthritis (RA) has changed dramatically over the past 15 years with the realisation that earlier, aggressive therapy limits progression. There is evidence that biological response modifiers (BRMs), which target specific cytokines such as TNF-alpha and IL-1, are more effective than traditional disease-modifying antirheumatic drugs (DMARDs), especially in combination with methotrexate. Four therapies are approved for use in RA; three target TNF-alpha (etanercept [Enbrel, Amgen Inc.], infliximab [Remicade, Centocor Inc.], and adalimumab [Humira, Abbott]), and one targets IL-1 (anakinra [Kineret, Amgen Inc.]). It is clear from both the clinical trials and postmarketing reports that all four agents have a different safety profile compared with traditional DMARDs. There are several areas of concern with the use of the BRMs, which include serious and opportunistic infections, malignancy/lymphoma, congestive heart failure, demyelination, injection/infusion reactions, development of autoantibodies and lupus-like disease. It is important to be fully aware of the safety profile and differences between BRMs in order to use them appropriately.
Calcium-Phospholipid-Phosphate Complexes in Mineralizing Tissue (1978)

Calcium - phospholipid - phosphate complexes have been isolated from mineralized tissues using a sonication-dependent method described previously and a new method which depends on the use of enzymes to remove the nonlipid matrix from tissues which were decalcified under mild conditions. Both methods gave comparable results. The complexes were found to be constituents of all mineralized rabbit tissues; bone, calcified cartilage, and tooth. No such complexes could be isolated from the nonmineralized tissues; muscle, ear cartilage, bone marrow, adipose tissue. The proportion of Ca-PL-PO4 is highest in those tissues which are involved in active mineralization, i.e., the younger tissues. All complexes isolated from mineralized tissues contain 50 mole % Ca, and variable amounts of the acidic phospholipids and inorganic phosphate. However, the Ca:total P molar ratio was always unity. All isolated complexes were shown to induce in vitro hydroxyapatite formation from metastable calcium phosphate solution and, thus, are believed to be associated with in vivo calcification.
Noise, Amplification, and Compression (1994)

This paper deals with the following three topics: (1) interfering noise (voice babble, single competing speaker) as the main problem of many hearing-impaired listeners, (2) the amplitude-frequency response of the hearing aid, and (3) the benefit of frequency-dependent compression. Research by the author and his coworkers has shown that: (1) persons with impaired hearing typically need 3 to 6 dB higher speech-to-noise ratios than do normal-hearing listeners--a technically very difficult problem to solve; (2) within a relatively ample range, the speech-reception threshold in noise is independent of the amplitude-frequency response; and (3) the small time constants of syllabic compression deteriorate the speech signal. Multichannel amplification (2-4 channels) with automatic gain control for each channel is recommended, optimally adjusted to keep the (variable) speech signal within the impaired ear's limited dynamic range as well as to preserve the intensity differences of successive speech phonemes.
Molecular Genetics Of Polyketides And Its Comparison To Fatty Acid Biosynthesis (1990)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Morphological studies of rat brain tumors induced by N-nitrosomethylurea (1971)

✓ Experimental glial tumors were induced by weekly intravenous injections of N-nitrosomethylurea (NNMU) in rats. The tumors included low- and high-grade gliomas of the astrocytic series and mixed gliomas. The histology of the tumors did not vary significantly with serial passage through tissue culture, subcutaneous implantation, or freezing. These neoplasms provide reliable animal models of brain tumors common to man.
Detection of hepatitis C virus RNA using ligation-dependent polymerase chain reaction in formalin-fixed, paraffin-embedded liver tissues. (1996)

Reverse transcription polymerase chain reaction (RT-PCR) has been used to detect hepatitis C virus (HCV) sequences in liver tissue. However, RT-PCR has a variable detection sensitivity, especially on routinely processed formalin-fixed, paraffin-embedded (FFPE) specimens. RNA-RNA and RNA-protein cross-links formed during formalin fixation is the major limiting factor preventing reverse trans criptase from extending the primers. To overcome this problem, we applied the ligation-dependent PCR (LD-PCR) for the detection of HCV RNA in FFPE liver tissue. This method uses two capture probes for RNA isolation and two hemiprobes for the subsequent PCR. Despite cross-links, the capture probes and the hemiprobes are able to form hybrids with HCV RNAs released from the FFPE tissue. The hybrids are isolated through binding of the capture probes to paramagnetic beads. The hemiprobes are then ligated by a T4 DNA ligase to form a full probe that serves as a template for the Taq DNA polymerase. A total of 22 FFPE liver specimens, 21 with hepatocellular carcinoma (HCC) and 1 with biliary cirrhosis secondary to bile duct atresia were selected for this study, of which 13 patients were HCV seropositive and 9 seronegative. HCV RNA was detectable by ID-PCR from all 13 HCV-seropositive HCCs and from 5 of 8 HCV-seronegative HCCs but not from the HCV-seronegative liver with biliary atresia. By contrast, RT-PCR detected HCV sequences in only 5 of the HCV-sero-positive and in 1 of the HCV-seronegative HCCs. To resolve the discordance between the LD-PCR and RT-PCR results, RT-PCR was performed on frozen liver tissue of the discrepant specimens, which confirmed the LD-PCR positive results. In conclusion, LD-PCR is a more sensitive method than RT-PCR for the detection of HCV sequences in routinely processed liver tissues. A high rate of HCV infection (86%) is found in HCC specimens, indicating a previously underestimated role of HCV in HCC pathogenesis.
Erratum: “Vertical scaling of carbon nanotube field-effect transistors using top gate electrodes” [Appl. Phys. Lett. 80, 3817 (2002)] (2002)

First Page
Broad-spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Combination with Anticancer Agents of Differing Mechanisms (2018)

Eribulin has combination activity with multiple agents from different mechanistic classes in several human cancer models, including breast, NSCLC, ovarian, and melanoma.
Functions of glutathione and glutathione disulfide in immunology and immunopathology (1994)

Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of lymphocytes in vitro. At low GSSG levels, T cells cannot optimally activate the immunologically important transcription factor NF kappa B, whereas high GSSG levels inhibit the DNA binding activity of NF kappa B. The effects of GSSG are antagonized by reduced thioredoxin (TRX). As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide, they are likely targets for GSSG action. These redox-regulated enzymes trigger signal cascades for NF kappa B activation and transduce signals from the T cell antigen receptor, from CD4 and CD8 molecules, and from the IL-2 receptor beta-chain. The effector phase of cytotoxic T cell responses and IL-2-dependent functions are inhibited even by a partial depletion of the intracellular GSH pool. As signal transduction is facilitated by prooxidant conditions, we propose that the well-known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency. As HIV-infected patients and SIV-infected rhesus macaques have, on the average, significantly decreased plasma cyst(e)ine and intracellular GSH levels, we also hypothesize that AIDS may be the consequence of a GSSG deficiency as well.
MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (2000)

A number of genes of the MAGE-A, B, and C families have been shown to code for antigens that are recognized on many human tumors by autologous cytolytic T lymphocytes. These antigens ought to be strictly tumor specific because the encoding MAGE genes are not expressed in normal adult cells except for male germline cells, which lack HLA expression. To identify new genes of this type, we performed representational difference analysis on a melanoma cell line by subtraction with a normal skin sample. This led to the identification of MAGE-C2, a new member of the MAGE-C family. A search for nucleotide sequences encoding MAGE-like proteins in public databases led to the identification of three additional MAGE genes, which were named MAGE-B5, MAGE-B6, and MAGE-C3. The four new MAGE genes are not expressed in normal tissues, except for testis, and are expressed in tumors of different histological origins. Therefore, like other MAGE genes expressed specifically in tumors, MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3 ought to encode antigens that could be targets for cancer immunotherapy.
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. (1995)

Pathways for regulation of signaling by transforming growth factor-beta family members are poorly understood at present. The best genetically characterized member of this family is encoded by the Drosophila gene decapentaplegic (dpp), which is required for multiple events during fly development. We describe here the results of screens for genes required to maximize dpp signaling during embryonic dorsal-ventral patterning. Screens for genetic interactions in the zygote have identified an allele of tolloid, as well as two novel alleles of screw, a gene recently shown to encode another bone morphogenetic protein-like polypeptide. Both genes are required for patterning the dorsalmost tissues of the embryo. Screens for dpp interactions with maternally expressed genes have identified loss of function mutations in Mothers against dpp and Medea. These mutations are homozygous pupal lethal, engendering gut defects and severely reduced imaginal disks, reminiscent of dpp mutant phenotypes arising during other dpp-dependent developmental events. Genetic interaction phenotypes are consistent with reduction of dpp activity in the early embryo and in the imaginal disks. We propose that the novel screw mutations identified here titrate out some component(s) of the dpp signaling pathway. We propose that Mad and Medea encode rate-limiting components integral to dpp pathways throughout development.
Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. (1996)

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes (CTL) are present in the peripheral blood and liver of chronically infected patients. The current study was performed to study the relationship between the strength of the CTL response, liver disease severity, and viral load. The results may be summarized as follows: first, using CTL precursor frequency (CTLpf) analysis to quantitate the peripheral blood CTL response, chronically infected patients were less strongly sensitized to a panel of well-defined HCV epitopes than they were to an epitope within the influenza matrix protein. Second, HCV-specific CTLpf did not correlate with disease activity or viral load in the majority of patients on a cross-sectional basis, although it did increase in three patients concomitant with sharp increases in liver disease. Finally, interferon therapy did not enhance the CTLpf against the HCV epitopes studied in these patients, indicating that its antiviral effect is independent of the CTL response. Since the HCV-specific CTLpf in the blood is actually quite low, the CTL may contribute to ongoing liver disease in these patients while being quantitatively inadequate to destroy all of the infected hepatocytes, thereby facilitating HCV persistence and contributing to chronic liver disease.
ChemInform Abstract: Concise Enantiospecific Syntheses of (+)‐Eldanolide and (‐)‐cis‐Whisky Lactone. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fibre amplifiers in closed-ring WDM networks (1992)

A selfconsistent solution is derived for an interoffice ring network consisting of a cascade of 11 erbium-doped fibre amplifiers that closes on itself and amplifies 15 wavelength-multiplexed signals. The accumulated signal-to-noise ratio is sufficient for 10Gbit/s operation at each wavelength, allowing a network capacity of 550Gbit/s for a full mesh traffic pattern.
Optical Neural Computers (1987)

The development of optical computers of any type is based on the notion that semiconductor technology imposes limitations in the performance of current computers which prevent them from being effectively used for the solution of a class of interesting computational problems. If optics is used instead, these limitations will be lifted and we will therefore be able to now solve these interesting problems. Global connectivity is perhaps the most distinctive feature of optics vis-a-vis semiconductor technology, and the development of optical neural computers can be viewed as an attempt to exploit this feature. In a neural network each elementary computational unit, the neuron, directly communicates to thousands of others, while in electronic computers each gate is typically connected to only two or three gates. With optics it is feasible to realize the dense connectivity that is evident in neural networks. This provides the impetus for examining neural network models of computation to get ideas about how to build optical computers whose performance is clearly better than their electronic counterparts.
Xenotransplantation panel for the detection of infectious agents in pigs (2018)

The data presented demonstrate that procedures in place are highly sensitive and can specifically detect nucleic acids from target organisms in the panel, thus ensuring the safety of organs for transplantation as well as the monitoring of patients potentially receiving them.
Reconfigurable adaptable micro-robot (2003)

The research on micro-robots with distributed intelligence, which are capable of reconfiguring themselves to adapt to various defense and civilian tasks, is relatively new. A team of interdisciplinary faculty from the College of Engineering at Michigan State University has taken this challenge and are designing micro-robots that incorporate learning, control and sensing. This paper presents the goals, and directions of this research along with the details of a preliminary design of one of the robots.
[Study of the relationship between complement activation and vascular endothelial damage in pregnancy induced hypertension]. (1996)

Not only the classical complement activation pathway but also the alternative complement activation pathway and complement regulatory protein play important roles in the pathogenesis of PIH, and complement activation and vascular endothelial damage is correlated. Evaluation of C1q, BF, C1-INH and CEC may be of value in clinical monitoring and management of PIH.
A Bacillus subtilis gene cluster similar to the Escherichia coli phosphate-specific transport (pst) operon: evidence for a tandemly arranged pstB gene (1996)

We have determined the complete nucleotide sequence of the Bacillus subtilis homologues of the Escherichia coli phosphate-specific transport (pst) genes in the framework of the international B. subtilis genome sequencing project. The pst genes in E. coli form an operon arranged in the order pstS, pstC, pstA, pstB and phoU. In the case of B. subtilis, there are also five ORFs presumably forming an operon. The deduced amino acid sequences of the products of these ORFs show striking similarities to their E. coli counterparts. Comparison of the organization of the pst operon of B. subtilis with that of E. coli revealed that the gene corresponding to phoU is missing, while there are two genes homologous to pstB in B. subtilis. The pst operon is located at 222 degrees on the B. subtilis chromosome.
The Efficacy of Intensive Dietary Therapy Alone or Combined with Lovastatin in Outpatients with Hypercholesterolemia (1993)

The effects of the low-fat-low-cholesterol diet and lovastatin on lipoprotein levels were independent and additive. However, the reduction in LDL cholesterol produced by the diet was small, and its benefit was possibly offset by the accompanying reduction in the level of HDL cholesterol.
Ultrasensitive scanometric strategy for detection of matrix metalloproteinases using a histidine tagged peptide–Au nanoparticle probe (2011)

A simple scanometric strategy was developed for ultrasensitive assay of matrix metalloproteinases based on their discriminatory and proteolytic activity by integrating a newly designed peptide-gold nanoparticle probe, a nitrilotriacetic acid modified chip and silver signal amplification.
Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. (1999)

Growth and dissemination of malignant melanoma has a profound impact on our population, and little is known concerning the mechanisms controlling this disease in humans. Evidence is provided that integrin alpha(v)beta3 plays a critical role in M21 melanoma tumor survival within human skin by a mechanism independent of its known role in angiogenesis. Antagonists of alpha(v)beta3 blocked melanoma growth by inducing tumor apoptosis. Moreover, M21 melanoma cell interactions with denatured collagen, a known ligand for alpha(v)beta3, caused a 5-fold increase in the relative Bcl-2:Bax ratio, an event thought to promote cell survival. Importantly, denatured collagen colocalized with alpha(v)beta3-expressing melanoma cells in human tumor biopsies, suggesting that alpha(v)beta3 interaction with denatured collagen may play a critical role in melanoma tumor survival in vivo.