gebhart/patrepeval huggingface dataset:
p75NTR Regulates Aβ Deposition by Increasing Aβ Production But Inhibiting Aβ Aggregation with Its Extracellular Domain (2011)

Accumulation of toxic amyloid-β (Aβ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease (AD). The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity; however, its role in the development of AD remains to be clarified. The p75NTR/ExonIII-/- mice and APPSwe/PS1dE9 mice were crossed to generate transgenic AD mice with deletion of p75NTR gene. In APPSwe/PS1dE9 transgenic mice, p75NTR expression was localized in the basal forebrain neurons and degenerative neurites in neocortex, increased with aging, and further activated by Aβ accumulation. Deletion of the p75NTR gene in APPSwe/PS1dE9 mice reduced soluble Aβ levels in the brain and serum, but increased the accumulation of insoluble Aβ and Aβ plaque formation. There was no change in the levels of amyloid precursor protein (APP) and its proteolytic derivatives, or α-, β-, and γ-secretase activities, or in levels of BACE1, neprilysin (NEP), and insulin-degrading enzyme (IDE) proteins. Aβ production by cortical neurons of APPSwe/PS1dE9 mice was reduced by deletion of p75NTR gene in vitro. Recombinant extracellular domain of p75NTR attenuated the oligomerization and fibrillation of synthetic Aβ(42) peptide in vitro, and reduced local Aβ plaques after hippocampus injection in vivo. In addition, deletion of p75NTR attenuated microgliosis but increased the microhemorrhage profiles in the brain. The deletion of p75NTR did not significantly change the cognitive function of the mice up to the age of 9 months. Our data suggest that p75NTR plays a critical role in regulating Aβ levels by both increasing Aβ production and attenuating its aggregation, and they caution that a therapeutic intervention simply reducing p75NTR may exacerbate AD pathology.
Compositionally Dependent Phase Identity of Colloidal CsPbBr3–xIx Quantum Dots (2016)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCompositionally Dependent Phase Identity of Colloidal CsPbBr3–xIx Quantum DotsPatrick Cottingham and Richard L. Brutchey*View Author Information Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States*R. L. Brutchey. Email: [email protected]Cite this: Chem. Mater. 2016, 28, 21, 7574–7577Publication Date (Web):October 19, 2016Publication History Received23 August 2016Revised15 October 2016Published online24 October 2016Published inissue 8 November 2016https://doi.org/10.1021/acs.chemmater.6b03553Copyright © 2016 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2340Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Perovskites,Phase transitions,Physical and chemical processes,Quantum dots,Scattering Get e-Alerts
Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. (2000)

The polo-like kinases (Plks) are a family of conserved serine/threonine kinases that play a critical role in the normal progression of cells through mitosis. The Plk3 serine/threonine kinase is a mammalian member of this family. Overexpression of Plk3 in mammalian cells suppresses proliferation and inhibits colony formation. Subsequent analysis demonstrated that overexpression of Plk3 induces chromatin condensation and apoptosis. This phenotype could not be inhibited by coexpression of Bcl-2 and was partially dependent on the COOH-terminal domain of Plk3 but not on the catalytic activity of Plk3. Analysis of EGFP-Plk3 subcellular localization revealed that Plk3 localizes to the cellular cortex and to the cell midbody during exit from mitosis and is consistent with a role in cytokinesis. These data suggest that overexpression or ectopic suppression of Plk3 interferes with cellular proliferation by impeding cytokinesis.
Incremental database systems (1993)

This paper discusses a new approach to database management systems that is better suited to a wide class of new applications such as scientific, hypermedia, and financial applications. These applications are characterized by their need to store large amounts of raw, unstructured data. Our premise is that, in these situations, database systems need a way to store data without imposing a schema, and a way to provide a schema incrementally as we process the data. This requires that the raw data be mapped in complex ways to an evolving schema.
Sams Teach Yourself Microsoft Publisher 2000 in 10 Minutes (1999)

From the Publisher:
Sams Teach Yourself Microsoft Publisher 2000 in 10 Minutes is the easiest way to learn the most important tasks that every user should know in Publisher 2000, the newest announced member of the Office 2000 family. Microsoft is opening up a whole new user base for the Publisher application. Users of Office who in the past have tried to force Word to perform complex desktop publishing tasks that it is not well suited to, will now have Publisher which is a much better tool for the job. Publisher's new standard Office interface will make it look more familiar and inviting to experienced Office users.
Chaperonin-promoted Post-translational Membrane Insertion of a Multispanning Membrane Protein Lactose Permease (1996)

Using an in vitro membrane-free translation system from Escherichia coli, it is shown that chaperonin GroEL added cotranslationally interacts with newly synthesized lactose permease (LacY), a polytopic membrane protein, thereby preventing aggregation. Subsequently, when the isolated GroEL-LacY complex is incubated with inverted membrane vesicles, the permease is inserted into the membrane in a MgATP-dependent manner. Post-translational membrane insertion is also observed when aggregation of newly synthesized LacY is prevented by addition of the nonionic detergent n-dodecyl-beta,D-maltoside during translation in place of GroEL. No membrane integration occurs with right-side-out vesicles, indicating that LacY interacts specifically only with the cytosolic face of the membrane. Ligand thiodigalactoside protection against alkylation of the Cys-148 residue in the permease shows proper post-translational insertion. Moreover, limited proteolysis of soluble LacY either complexed with GroEL or in detergent indicates that the newly synthesized protein assumes a conformation that is comparable to that of native, membrane-embedded permease prior to insertion into the membrane.
Bionics in Tissue Engineering (2017)

This chapter reviews the current state of bionics systems containing both biological tissues and electronic components. Bionic tissues require the integration of electronic components with biological cells in order to monitor, repair, or enhance electrical function. The first step toward this goal is to create electronic devices that can effectively interface with cells or tissues and perform the desired tasks. The chapter discusses novel electronic materials that have been used to stimulate or record signals from tissue. It also discusses recent advances in gold and silicon nanomaterials, which have been crucial in the areas of tissue regeneration and nanoelectronics, respectively. The development of new energy sources is particularly important within the context of the bionics, since those systems are often designed to be small, biodegradable, and biologically benign. The chapter reviews new technologies that could be incorporated into future bionic systems.
Face detection in complex environments from color images (2003)

The detection of faces in color images is important for many multimedia applications. It is the first step for face recognition and it can be used for classifying specific shots such as anchorperson and talk show shots. In this paper, we present an algorithm for the detection of faces in color images. The algorithm works by first detecting areas of skin color, then it applies a top-down and a bottom-up analysis to the skin colored areas. The algorithm has been tested on images from news clips and other television programs. The results show that the algorithm is robust and works even for cases where there are objects in the background that have colors similar to the skin.
The development of 'soft' strategic indicators for international client satisfaction (2004)

\n\t\t\t\t\tDespite the increasing significance of the construction industry as an emerging sector of the Australian economy, there is inadequate research performed on construction design firms in terms of theoretical and empirical foundations. Although past research has identified the barriers and success factors for firm market entry, evidence suggests that to date no research has explicitly explored the sustainability of construction design firms in international markets. SMEs and their approach to firm internationalisation differ significantly from large manufacturing firms and a vast majority of construction design firms operate as SMEs. This paper develops a sustainable business model for construction design SMEs, which rely upon the development of clear Client Following (CF) versus Market Seeking (MS) strategies to support internal firm strategic and operational management. The understanding of these strategies is vital as the application of either will shape the design management approach of firms, which would in turn impact on the sustainability of these firms in foreign markets. Long-term sustainability of firms in international markets relies heavily upon client satisfaction. Client and project team participants&amp;rsquo; communication during various design processes has often been problematic and the added difficulty of communicating across international boundaries further compounds the problem of capturing and maintaining client&amp;rsquo;s requirements. Therefore this paper develops a model for business sustainability of Australian construction design firms working in international markets by exploring factors that affect client satisfaction across international boundaries, through the development of business performance indicators. These include not only the critical financial capital but also other &amp;lsquo;softer&amp;rsquo; indicators, namely: social, cultural and intellectual capital. These act as a firm&amp;rsquo;s measure of success and the acquisition of this type of capital will provide significant advantages to firms&amp;rsquo; success, hence sustainability in international markets.&lt;br /&gt;\n\t\t\t\t
V Region Carbohydrate and Antibody Expression (2004)

N-Linked carbohydrates are frequently found in the V region of Ig H chains and can have a positive or negative effect on Ag binding affinity. We have studied a murine anti-alpha(1-->6) dextran V(H) that contains a carbohydrate in complementarity-determining region 2 (CDR2). This carbohydrate remains high mannose rather than being processed to a complex form, as would be expected for glycans on exposed protein loops. We have shown that the glycan remained high mannose when murine-human chimeric Abs were produced in a variety of cell types. Also, when another carbohydrate was present in CDR1, CDR2, or CDR3 of the L chain, the V(H) CDR2 glycan remained high mannose. Importantly, we found that when the anti-dextran V(H) CDR2 replaced CDR2 of an anti-dansyl V(H), the glycosylation site was used, but H chains were withheld in the endoplasmic reticulum and did not traffic to the Golgi apparatus. These results suggest that inappropriate V region glycosylation could contribute to ineffective Ab production from expressed Ig genes. In some cases, a carbohydrate addition sequence generated by either V region rearrangement or somatic hypermutation may result in an Ab that cannot be properly folded and secreted.
Activated Complement Factors as Disease Markers for Sepsis (2015)

Sepsis is a leading cause of death in the United States and worldwide. Early recognition and effective management are essential for improved outcome. However, early recognition is impeded by lack of clinically utilized biomarkers. Complement factors play important roles in the mechanisms leading to sepsis and can potentially serve as early markers of sepsis and of sepsis severity and outcome. This review provides a synopsis of recent animal and clinical studies of the role of complement factors in sepsis development, together with their potential as disease markers. In addition, new results from our laboratory are presented regarding the involvement of the complement factor, mannose-binding lectin, in septic shock patients. Future clinical studies are needed to obtain the complete profiles of complement factors/their activated products during the course of sepsis development. We anticipate that the results of these studies will lead to a multipanel set of sepsis biomarkers which, along with currently used laboratory tests, will facilitate earlier diagnosis, timely treatment, and improved outcome.
Etk/Bmx Regulates Proteinase-Activated-Receptor1 (PAR1) in Breast Cancer Invasion: Signaling Partners, Hierarchy and Physiological Significance (2010)

This is the first demonstration that a cytoplasmic portion of the PAR(1) C-tail functions as a scaffold site. We identify here essential signaling partners, determine the hierarchy of binding and provide a platform for therapeutic vehicles via definition of the critical PAR(1)-associating region in the breast cancer signaling niche.
EXPERIMENTAL OBSERVATIONS OF ROCK FAILURE DUE TO LASER RADIATION (1969)

Massachusetts Institute of Technology. Dept. of Civil Engineering. Thesis. 1969. M.S.
Lymphocyte Motility and Lymphocyte Chemoattractant Factors (1988)

(1988). Lymphocyte Motility and Lymphocyte Chemoattractant Factors. Immunological Investigations: Vol. 17, No. 8-9, pp. 625-677.
Oral candidiasis: An overview (2014)

Candida is the shortened name used to describe a class of fungi that includes more than 150 species of yeast. In healthy individuals, Candida exists harmlessly in mucus membranes such as your ears, eyes, gastrointestinal tract, mouth, nose, reproductive organs, sinuses, skin, stool and vagina, etc. It is known as your "beneficial flora" and has a useful purpose in the body. When an imbalance in the normal flora occurs, it causes an overgrowth of Candida albicans. The term is Candidiasis or Thrush. This is a fungal infection (Mycosis) of any of the Candida species, of which Candida albicans is the most common. When this happens, it can create a widespread havoc to our overall health and well-being of our body.
Leadership and politics: a perspective from the Growth Commission (2009)

The paper attempts via case studies to illustrate the nature and importance of political structures and transitions in the course of rapid growth and development. The cases are drawn principally from Asia, where the pattern has often been a dominant single-party structure evolving into a full multi-party democratic structure. This results from the interaction of the politics and changes that result from the growth process itself, such as the emergence of politically active middle and entrepreneurial classes. The role of political leadership in managing, sequencing, and pacing these transitions is discussed. We do not yet have a general model for which these cases would be instances. The hope is that an in-depth understanding of the case dynamics will be a useful input to the development and testing of more general theories.
Using domain ontologies in a dynamic analysis for program comprehension (2010)

The use of domain knowledge for program comprehension has been advocated by many authors. However, as far as we know, most of the analysis techniques using domain knowledge are static, it seems that dynamic analyses have not yet taken full advantage of any domain knowledge. This might be a consequence of ontologies, the most common technique for domain knowledge representation, being static by nature. In this article we present a new kind of dynamic analysis that attempts to use domain knowledge from two ontologies: that of the domain concepts and another one we called the "Ontology of Domain Actions". To take advantage of this later source of knowledge, we had to specify what actions were expected to be performed by the software at any moment in time. This has been done using a variant of the CRC cards formalism. As a result, we are able to match the actions actually performed by the software with expectations using dynamic analysis based on the action ontology.
Low-Density Lipoprotein Particle Concentration and Size as Determined by Nuclear Magnetic Resonance Spectroscopy as Predictors of Cardiovascular Disease in Women (2002)

In this cohort, LDL particle concentration measured by NMR spectroscopy was a predictor of future cardiovascular risk. However, the magnitude of predictive value of LDL particle concentration (NMR) was not substantively different from that of the total cholesterol to HDL cholesterol ratio and was less than that of C-reactive protein.
Alpha-adrenoceptor stimulation induces hypertrophy and increases L-type calcium current density in neonatal rat ventricular cardiomyocytes in culture. (2000)

Effects of chronic alpha-adrenoceptor stimulation on hypertrophy and L-type calcium current (I(Ca-L) ) were investigated in neonatal rat ventricular cardiomyocytes in culture using whole-cell patch-clamp technique and measurement of protein- and RNA-to-DNA ratios. Chronic exposure to norepinephrine (2 microM) plus propranolol (2 microM) of cardiomyocytes during 1 and 3 days in culture increased cell membrane capacitance, protein- and RNA-to DNA ratios and was accompanied by an increase in I(Ca-L) density. These effects were not observed in the presence of prazosin (2 microM) suggesting that they could be due to alpha(1) -adrenoceptor stimulation. They were also prevented by cycloheximide (5 microM) and actinomycin D (1 microM). These effects were not observed in 1 and 3 day-cultured cells pre-treated for only 1 hour with norepinephrine. They were potentiated when calcium concentration was increased in the culture medium and, in contrast they were abolished in the presence of the L-type calcium current inhibitor, nifedipine (2 microM). The present study demonstrates that hypertrophy induced by long-term stimulation of alpha(1) -adrenoceptors is accompanied by an increase in the expression of functional calcium channels in neonatal rat cardiomyocytes. These results reveal the existence of a novel alpha(1) -mediated positive regulation of L-type calcium current different from that due to acute stimulation of alpha(1) -adrenoceptors in neonatal ventricular cardiomyocytes.
Characterization of a Cys329Gly Mutation Causing Hereditary Factor VII Deficiency (2006)

We have previously reported a homozygous Cys329Gly mutation in a Chinese patient with factor VII (FVII) deficiency. Others have found a heterozygous Cys329Gly mutation in the F7 gene from patients of three different pedigrees. However, none of the reports included the expression and characterization of the mutant FVII in vitro. To investigate the effect of Cys329Gly on FVII function, we carried out transient transfections of baby hamster kidney cells (BHK-21) with a mutant FVII construct and compared the results to those obtained using a wild-type FVII construct and vector control. The results demonstrate that the level of FVII:Ag secreted into the medium by transfected BHK-21 cells with mutant construct was not affected, but the coagulation activity of the mutant FVII was undetectable. We conclude that Cys329 is critical to FVII coagulation, and the replacement of cysteine 329 by glycine leads to the loss of coagulation activity in the patients, possibly the molecular basis for FVII deficiency in the patients.
Alkyl phosphotriesters of dinucleotides and oligonucleotides. 4. Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acid (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkyl phosphotriesters of dinucleotides and oligonucleotides. 4. Synthesis of oligodeoxyribonucleotide ethyl phosphotriesters and their specific complex formation with transfer ribonucleic acidPaul S. Miller, J. C. Barrett, and Paul O. P. Ts'oCite this: Biochemistry 1974, 13, 24, 4887–4896Publication Date (Print):November 1, 1974Publication History Published online1 May 2002Published inissue 1 November 1974https://pubs.acs.org/doi/10.1021/bi00721a003https://doi.org/10.1021/bi00721a003research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Production of Uniform Microspheres (1973)

A new technique has been developed for producing microspheres uniform in volume and fluorescence or radioactive tracer. Very uniform spheres with selected diameters are produced by introducing one liquid into the center of a moving stream of a second liquid (of differing surface tension) and breaking the core stream into uniform droplets by the action of a piezoelectric transducer. Fluorescent spheres of 10 μ diam have been produced having a coefficient of variation in volume and fluorescence as low as 3.6%. This corresponds to a diameter variation of about 1.5%.