gebhart/patrepeval huggingface dataset:
Fabrication of SiGe-on-Insulator through Thermal Diffusion of Ge on Si-on-Insulator Substrate (2003)

We report on the fabrication of a homogeneous SiGe-on-insulator as a substrate for strained Si-on-insulator (SOI) metal-oxide-semiconductor field-effect-transistors. The fabrication process includes the growth of a thin Ge film on a commercially available SOI substrate at 100°C using a molecular beam epitaxy system, the formation of a SiO2 cap layer by radio-frequency sputtering, and rapid thermal annealing (RTA) in an Ar atmosphere. After RTA at an appropriate temperature, the SiGe-on-insulator with a laterally homogeneous Si fraction was successfully obtained by the formation of epitaxial SiGe on a thin SOI as a seed and interdiffusion of Ge and Si atoms. However, inhomogeneous SiGe films were obtained when the annealing temperature was very high. The conditions for the realization of SiGe with a homogeneous Si fraction were found to be closely related to the phase diagram of the Si–Ge binary alloy.
Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic MABS C225 and 425 (2008)

AbstractMonoclonal antibodies (mAbs) that inhibit activation of the epidermal growth factor receptor (EGFR) have shown therapeutic potential in select malignancies including breast cancer. Here, we describe that combined use of two such mAbs, C225 (Cetuximab) and 425 (EMD55900), reduced growth and survival of EGFR overexpressing MDA-MB-468 breast cancer cells more effectively than either antibody alone. Similarly, the C225/425 antibody combination more effectively inhibited AKT and MAPK phosphorylation in MDA-MB-468 cells. Surface plasmon resonance, size exclusion chromatography, and analytical ultracentrifugation demonstrated that mAbs C225 and 425 simultaneously bind to distinct antigenic epitopes on domain III of the soluble wild-type EGFR. Furthermore, neither mAb competed with the other for binding to cells expressing either wild-type EGFR or a mutant EGFR (EGFRvIII) associated with neoplasia. Mutagenesis experiments revealed that residues S460/G461 in EGFR domain III are essential components of the 425 epitope and clearly distinguish it from the EGF/ TGF-α binding site and the C225 interaction interface. Collectively, these results support the conclusion that therapeutic EGFR blockade in cancer patients by combined use of mAbs C225 and 425 could provide advantages over the use of the two antibodies as single agents.
Enhanced HIV replication in macrophage colony-stimulating factor-treated monocytes (1991)

Monocytes cultured 7 to 10 days in recombinant human macrophage CSF (MCSF) were greater than 400-fold more susceptible to HIV infection than an equal number of cells cultured in medium alone. Levels of reverse transcriptase activity and p24 Ag in culture fluids of monocytes treated with MCSF 1 wk before and continuously after HIV infection were significantly greater than those of control cells cultured without MCSF. HIV-induced cytopathic effects in the MCSF-treated cultures also increased in both frequency and extent. At any given viral inoculum, the frequency of HIV-infected cells, the level of HIV mRNA/infected cell, and the level of proviral DNA/infected culture in MCSF-treated monocyte cultures were dramatically greater than those in control cultures. These differences were directly related to MCSF concentration to a maximum between 750 and 1000 U/ml MCSF, and were evident at all time points examined through 5 wk. None of the preceding effects was observed when MCSF was added at the time of or 1 wk after HIV infection. These data suggest that the predominant effect of MCSF for control of HIV infection is on the monocyte itself, not the virus. If these in vitro observations extend to the HIV-infected patient, then the variable levels of MCSF in tissue or blood may determine both the susceptibility of macrophages to virus infection and the extent of virus replication in infected cells.
expanded: a gene involved in the control of cell proliferation in imaginal discs (1993)

The expanded gene was first identified by a spontaneous mutation that causes broad wings. We have identified an enhancer-trap insertion within expanded and used it to generate additional mutations, including one null allele. expanded is an essential gene, necessary for proper growth control of imaginal discs and, when mutant, causes either hyperplasia or degeneration depending on the disc. Wing overgrowth in expanded hypermorphs is limited to specific regions along the anterior-posterior and dorsal-ventral axis. expanded encodes a novel 1429 amino acid protein that is localized to the apical surface of disc cells and contains three potential SH3-binding sites. Together, these observations suggest that the Expanded protein engages in protein-protein interactions regulating cell proliferation in discs.
Heterogenization of Metallocene Catalysts for Alkene Polymerization (1999)

Beyond mere convenience: In large-scale industrial processes for alkene polymerization the essentially homogeneous metallocene/activator catalyst systems are heterogenized (example shown) to improve polymer properties. New mesoporous and organic catalyst supports and their application in this field of catalysis are described.
Cell bank characterization for recombinant DNA mammalian cell lines. (1985)

Cell banks were created by controlled rate freezing of pooled cell suspensions. Each line was characterized for freedom from adventitious agents, identity and biological behavior in immunosuppressed animals. Pharmacopeal culture methods were employed to search for bacterial, fungal and mycoplasma contamination. Conditioned medium was inoculated into a battery of 6 cell lines to search for acute viral contamination. Recombinant cell lines were also examined for retroviruses by electron microscopy, reverse transcriptase assay, XC plaque assay, tritiated uridine labelling, chemical induction techniques, and co-cultivation with three indicator cell lines. Further characterization was obtained from inoculation of 4 animal species in vivo, mouse antibody production test, and inoculation of immunosuppressed rodents. Finally, cytogenetic evaluation including banding methods and isoenzyme analysis were employed to verify cell bank identity. These methods have generated useful data concerning the identity, safety, and biological purity of recombinant DNA mammalian cell lines.
Fluorinated Derivatives of Propane and Propylene. VI (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorinated Derivatives of Propane and Propylene. VIAlbert L. Henne and T. Phillip WaalkesCite this: J. Am. Chem. Soc. 1946, 68, 3, 496–497Publication Date (Print):March 1, 1946Publication History Published online1 May 2002Published inissue 1 March 1946https://pubs.acs.org/doi/10.1021/ja01207a041https://doi.org/10.1021/ja01207a041research-articleACS PublicationsRequest reuse permissionsArticle Views441Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Roles of Toll‐like receptors in innate immune responses (2001)

Innate immunity recognizes invading micro-organisms and triggers a host defence response. However, the molecular mechanism for innate immune recognition was unclear. Recently, a family of Toll-like receptors (TLRs) was identified, and crucial roles for these receptors in the recognition of microbial components have been elucidated. The TLR family consists of 10 members and will be expanding. Each TLR distinguishes between specific patterns of microbial components to provoke innate immune responses. The activation of innate immunity then leads to the development of antigen-specific adaptive immunity. Thus, TLRs control both innate and adaptive immune responses.
Studies of endotoxin-induced decrease in lipoprotein lipase activity. (1981)

A variety of invasive stimuli have been shown to induce hyperlipidemia due to impaired removal of triglyceride from the circulation. The mechanism by which endotoxin induces a deficiency in the activity of the key enzyme of triglyceride metabolism, lipoprotein lipase (LPL), has been studied. In C3H/HeN (endotoxin-sensitive) mice, LPL activity in adipose tissue was markedly suppressed 16 h after endotoxin administration. In contrast, the endotoxin-resistant C3H/HeJ mice were less sensitive to the suppressive effect of endotoxin on LPL activity. After endotoxin administration, a transferable factor had been detected in the blood of C3H/HeN mice 2 h after the injection of endotoxin that causes a suppression of adipose tissue LPL activity in C3H/HeJ mice as well as in C3H/HeN mice. Conditioned medium from the cultures of peritoneal exudate cells of C3H/HeN mice incubated in endotoxin also suppresses adipose tissue LPL in C3H/HeJ mice. These studies demonstrate that exudate cells produce a humoral factor in response to endotoxin, which suppresses adipose tissue LPL.
Preference-based decision making for cooperative knowledge-based systems (1994)

Recent advances in cooperative knowledge-based systems (CKBS) offer significant promise for intelligent interaction between multiple AI systems for solving larger, more complex problems. In this paper, we propose a logical, qualitative problem-solving scheme for CKBS that uses social choice theory as a formal basis for making joint decisions and promoting conflict resolution. This scheme consists of three steps: (1) the selection of decision criteria and competing alternatives, (2) the formation of preference profiles and collective choices, and (3) the negotiation among agents as conflicts arise in group decision making. In this paper, we focus on the computational mechanisms developed to support steps (2) and (3) of the scheme. In addition, the practicality of the scheme is illustrated with examples taken from a working prototype dealing with collaborative structural design of buildings.
Current density distributions, field distributions and impedance analysis of segmented deep brain stimulation electrodes (2005)

Deep brain stimulation (DBS) electrodes are designed to stimulate specific areas of the brain. The most widely used DBS electrode has a linear array of 4 cylindrical contacts that can be selectively turned on depending on the placement of the electrode and the specific area of the brain to be stimulated. The efficacy of DBS therapy can be improved by localizing the current delivery into specific populations of neurons and by increasing the power efficiency through a suitable choice of electrode geometrical characteristics. We investigated segmented electrode designs created by sectioning each cylindrical contact into multiple rings. Prototypes of these designs, made with different materials and larger dimensions than those of clinical DBS electrodes, were evaluated in vitro and in simulation. A finite element model was developed to study the effects of varying the electrode characteristics on the current density and field distributions in an idealized electrolytic medium and in vitro experiments were conducted to measure the electrode impedance. The current density over the electrode surface increased towards the edges of the electrode, and multiple edges increased the non-uniformity of the current density profile. The edge effects were more pronounced over the end segments than over the central segments. Segmented electrodes generated larger magnitudes of the second spatial difference of the extracellular potentials, and thus required lower stimulation intensities to achieve the same level of neuronal activation as solid electrodes. For a fixed electrode conductive area, increasing the number of segments (edges) decreased the impedance compared to a single solid electrode, because the average current density over the segments increased. Edge effects played a critical role in determining the current density distributions, neuronal excitation patterns, and impedance of cylindrical electrodes, and segmented electrodes provide a means to increase the efficiency of DBS.
Plasma-enhanced atomic layer deposition of Ta and Ti for interconnect diffusion barriers (2000)

Thin films of inert, refractory materials are used in semiconductor interconnect applications as diffusion barriers, seed, and adhesion layers. A typical example is the use of a thin, conformal Ta or Ti/TiN films on the walls of a dielectric trench or via which reduces or eliminates out-diffusion of the primary conductor, usually Cu, into the dielectric. Atomic layer deposition is a known technique which is intrinsically conformal and is appropriate for this application. Plasma enhancement of the process allows deposition at significantly lower temperatures than conventional chemical vapor deposition, which is a requirement for low-k dielectrics. Tantalum films deposited at 25–400 °C using ALD with a TaCl5 precursor and atomic hydrogen as the reactive species at up to a rate of 1.67 Ang/cycle are amorphous, conformal, and show moderate or controllable levels of impurities; primarily oxygen and a small level of Cl. Similar results have been observed for Ti using TiCl4 as a precursor. The process scales to manufacturing dimensions and applications and will facilitate the extension of interconnect technology beyond (below) 100 nm dimensions.
Illustrative shadows (2003)

Many exploration and manipulation tasks benefit from a coherent integration of multiple views onto complex information spaces. This paper proposes the concept of Illustrative Shadows for a tight integration of interactive 3D graphics and schematic depictions using the shadow metaphor. The shadow metaphor provides an intuitive visual link between 3D and 2D visualizations integrating the different displays into one combined information display. Users interactively explore spatial relations in realistic shaded virtual models while functional correlations and additional textual information are presented on additional projection layers using a semantic network approach. Manipulations of one visualization immediately influence the others, resulting in an in-formationally and perceptibly coherent presentation
Structural requirements for antimicrobial versus chemoattractant activities for dermaseptin S9 (2008)

Dermaseptin S9 (Drs S9), GLRSKIWLWVLLMIWQESNKFKKM, isolated from frog skin, does not resemble any of the cationic and amphipathic antimicrobial peptides identified to date, having a highly hydrophobic core sequence flanked at either side by cationic termini. Previous studies [Lequin O, Ladram A, Chabbert A, Bruston F, Convert O, Vanhoye D, Chassaing G, Nicolas P & Amiche M (2006) Biochemistry45, 468-480] demonstrated that this peptide adopted a non-amphipathic alpha-helical conformation in trifluoroethanol/water mixtures, but was highly aggregated in aqueous solutions and in the presence of sodium dodecyl sulfate micelles. Circular dichroism, FTIR and attenuated total reflectance FTIR spectroscopies, combined with a surface plasmon resonance study, show that Drs S9 forms stable and ordered beta-sheet aggregates in aqueous buffers or when bound to anionic or zwitterionic phospholipid vesicles. These structures slowly assembled into amyloid-like fibrils in aqueous environments via spherical intermediates, as revealed by electron microscopy and Congo red staining. Drs S9 induced the directional migration of neutrophils, T lymphocytes and monocytes. Interestingly, the antimicrobial and chemotactic activities of Drs S9 are modulated by its amyloid-like properties. Whereas spherical oligomers of Drs S9 exhibit antimicrobial activity, the soluble, weakly self-associated forms of Drs S9 act on human leukocytes to promote chemotaxis and/or immunological response activation in the same range of concentration as amyloidogenic peptides Abeta(1-42), the most fibrillogenic isoform of amyloid beta peptides, and the prion peptide PrP(106-126).
Additive Effect of the Combined Administration of Low Molecular Weight Heparin and Recombinant Hirudin on Thrombus Growth in a Rabbit Jugular Vein Thrombosis Model (1994)

Recombinant hirudin (r-hirudin) is a new anticoagulant with specific antithrombin activity independently of antithrombin III. Low molecular weight heparins (LMWH) exert predominantly anti-Xa activity. Therefore, we hypothesized that combined administration of r-hirudin and LMWH would induce a stronger antithrombotic effect as compared to r-hirudin administered alone or combined with unfractionated heparin. To assess the effect on thrombus growth, we determined the accretion of 125I-labeled fibrinogen onto autologous non-radioactive thrombi preformed in the jugular veins of rabbits. The rabbits received unfractionated heparin (80 anti-factor Xa U), LMWH (80 anti-factor Xa U) or r-hirudin (0.3, 5.0 and 10.0 mg/kg) either separately or by combined infusion for a 3 h period. R-Hirudin reduced the thrombus growth in a dose dependent fashion. The combined administration of 80 anti-Xa U LMWH and r-hirudin at a dose of 0.3 mg/kg resulted in a stronger antithrombotic effect as compared to the combined infusion of unfractionated heparin and r-Hirudin (thrombus growth: 14.3% +/- 6.0 vs 28.9% +/- 6.5; p = 0.001). This difference in additive antithrombotic effect of 80 anti-Xa U LMWH versus unfractionated heparin on r-hirudin was also observed when LMWH was combined with 5.0 mg/kg and 10.0 mg/kg r-hirudin versus unfractionated heparin combined with r-hirudin (thrombus growth: 16.4% +/- 1.6 vs 29.1% +/- 3.9; p = 0.01 and 10.1% +/- 1.8 vs 20.4% +/- 4.5; p = 0.001, respectively). In conclusion, this study showed an additive antithrombotic effect of LMWH on the thrombus growth reducing effect of r-hirudin.(ABSTRACT TRUNCATED AT 250 WORDS)
Electric Power Systems in More and All Electric Aircraft: A Review (2020)

Narrow body and wide body aircraft are responsible for more than 75% of aviation greenhouse gas (GHG) emission and aviation, itself, was responsible for about 2.5% of all GHG emissions in the United States in 2018. This situation becomes worse when considering a 4-5% annual growth in air travel. Electrified aircraft is clearly a promising solution to combat the GHG challenge; thus, the trend is to eliminate all but electrical forms of energy in aircraft power distribution systems. However, electrification adds tremendously to the complexity of aircraft electric power systems (EPS), which is dramatically changing in our journey from conventional aircraft to more electric aircraft (MEA) and all electric aircraft (AEA). In this article, we provide an in-depth discussion on MEA/AEA EPS: electric propulsion, distributed propulsion systems (DPS), EPS voltage levels, power supplies, and EPS architectures are discussed. Publications on power flow (PF) analysis and management of EPS are reviewed, and an initial schematic of a potential aircraft EPS with electric propulsion is proposed. In this regard, we also briefly review the components required for MEA/AEA EPS, including power electronics (PE) converters, electric machines, electrochemical energy units, circuit breakers (CBs), and wiring harness. A comprehensive review of each of the components mentioned above or other topics except for those related to steady state power flow in MEA/AEA EPS is out of this article's scope and should be found somewhere else. At the close of the paper, some challenges in the path towards AEA are presented. Unless the discussed challenges are satisfactorily addressed and solved, arriving at an AEA that can properly operate over commercial missions will not be possible.
Self-aligned germanium MOSFETs using a nitrided native oxide gate insulator (1988)

The fabrication and performance of dummy-gate self-aligned germanium MOSFETs utilizing a native germanium oxynitride gate insulator is reported. Based on device characteristics, channel mobility at 300 K is estimated as 940 cm/sup 2//Vs. Common-source characteristics show good saturation and turn-off, and do not exhibit looping or other anomalies. It is felt these results suggest that integration of germanium MOSFETs with photodiodes for monolithic optical-fiber receivers operating at 1.3- mu m wavelength should be possible. The results also indicate that the bulk mobility advantage which germanium exhibits relative to silicon carries over in some measure to FET channel mobility.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Air Classification and Extrusion of Navy Bean Fractions (1984)

ABSTRACT Pilot plant air classification or raw beans ( Phaseolus vulgaris ) produced high‐protein fractions (HPF) containing 51.4% protein and high‐starch fractions (HSF) having about 50% starch. Particle size distribution analyses and scanning electron micrographs confinned the fractionation of starchy and proteinaceous materials. Extruded corn/HSF blends had lower water absorption and water solubility indices, higher protein content, and a better balanced amino acid pattern than pure corn extrudates. Extrusion‐texturized vegetable proteins obtained by substituting HPF for defatted soy flour at levels of 10, 20 and 30% had similar functional properties as the 100% texturized soy. Air classification followed by extrusion‐cooking is a feasible alternative for dry‐processing of beans into products for human consumption.
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. (1995)

The neuronal microtubule-associated protein tau is required for the development of cell polarity in cultured neurons. Using PC12 cells that stably express tau and tau amino-terminal fragments, we report that tau interacts with the neural plasma membrane through its amino-terminal projection domain. In differentiated PC12 transfectants, tau is found in growth cone-like structures in a nonmicrotubule-dependent manner. In hippocampal neurons, tau is differentially extracted by detergent and enriched in the growth cone and the distal axon when membrane is left intact. In PC12 transfectants, overexpression of tau's amino-terminal fragment, but not of full-length tau, suppresses NGF-induced process formation. Our data suggest that tau's amino-terminal projection domain has an important role in neuritic development and establishes tau as a mediator of microtubule-plasma membrane interactions.