gebhart/patrepeval huggingface dataset:
mTOR Pathway and mTOR Inhibitors as Agents for Cancer Therapy (2008)

Research into mTOR, mammalian Target Of Rapamycin as an important drug target continues to be extremely interesting, both in terms of the increased molecular knowledge being acquired at the basis of various human diseases, and also for possible applications in drug cancer therapy. The mTOR signaling system plays a key role in several transduction pathways that are necessary for cell cycle progression and cellular proliferation. Drugs known as mTOR inhibitors have been included in ongoing and in recently completed cancer trials. New insights into the mTOR signaling system are helping to clarify the functionality of key mTOR components, and especially their possible role in apoptosis, angiogenesis and tumor progression. Three other molecules, already approved for therapeutic use and being commercialized (Everolimius, Temsirolimus and Zotarolimus) are added to Rapamycin (also known as Sirolimus), the parent drug of the mTOR inhibitors. Of these, only Temsirolimus is currently approved in the treatment of renal cell carcinoma, while the others are approved for organ transplant rejection and coronary artery restenosis. There are at least 10 other molecules currently under development for clinical and preclinical studies. This review offers an updated synopsis of the mTOR signaling system, in particular as regards relevant aspects of cancer research, looks at the known mTOR inhibitors and gives a systematic vision of current trials for each individual molecule subject to clinical investigation.
DYNAMICS OF LAKE ERUPTIONS AND POSSIBLE OCEAN ERUPTIONS (2006)

Dissolved gas in liquid is able to power violent eruptions. Two kinds of such gas-driven eruptions are known in nature: explosive volcanic eruptions driven by dissolved H 2 O in magma at high temperatures and lake eruptions driven by dissolved CO 2 in water at low temperatures. There are two known occurrences of lake eruptions, one in 1984 (Lake Monoun) and one in 1986 (Lake Nyos), both in Cameroon, Africa. The erupted CO 2 gas asphyxiated ∼1700 people in the Lake Nyos eruption and 37 people at Lake Monoun. Here we review experimental simulations of CO 2 -driven water eruptions and dynamic models of such eruptions, and a bubble plume theory is applied to the dynamics of lake eruptions. Field evidence, experimental results, and theoretical models show that lake eruptions can be violent, and theoretical calculations are consistent with the high exit velocities and eruption columns inferred from observations. Furthermore, the dynamics of lake degassing experiments are consistent with theoretical models. Other kinds of gas-driven eruptions are possible and may have occurred in nature in the past. A concentrated and large release of methane gas or hydrate from marine sediment may result in an ocean eruption. Furthermore, injection of liquid CO 2 into oceans might also lead to ocean eruptions if care is not taken. The various kinetic and dynamic processes involved are examined and quantified.
The restricted isometry property and its implications for compressed sensing (2008)

It is now well-known that one can reconstruct sparse or compressible signals accurately from a very limited number of measurements, possibly contaminated with noise. This technique known as “compressed sensing” or “compressive sampling” relies on properties of the sensing matrix such as the restricted isometry property . In this Note, we establish new results about the accuracy of the reconstruction from undersampled measurements which improve on earlier estimates, and have the advantage of being more elegant.
Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase (1999)

The mitogen-activated protein (MAP) kinase pathway is a critical regulator of cell growth, migration, and differentiation. Growth factor activation of MAP kinase in NIH 3T3 cells is strongly dependent upon integrin-mediated adhesion, an effect that contributes to the anchorage dependence of normal cell growth. We now show that expression of constructs that constitutively activate focal adhesion kinase (FAK) rescued the defect in serum activation of MAP kinase in suspended cells without directly activating MAP kinase. Dominant negative FAK blocked both the rescue of suspended cells by the activated construct and the serum activation of MAP kinase in adherent cells. MAP kinase in FAK(-/)- mouse embryo fibroblasts was adhesion-insensitive, and reexpression of FAK restored its adhesion dependence. MAP kinase activity in ras-transformed cells is still decreased in suspension, but expression of constructs that constitutively activate FAK enhanced their anchorage-independent growth without increasing adherent growth. V-src, which activates both Ras and FAK, induced MAP kinase activation that was insensitive to loss of adhesion, and that was blocked by a dominant negative FAK. These results demonstrate that FAK mediates the integrin requirement for serum activation of MAP kinase in normal cells, and that bypassing this mechanism contributes to anchorage-independent growth in transformed cells.
Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase (1995)

Phosphatidylinositol (Pl)-3 kinase is one of many enzymes stimulated by growth factors. A constitutively activated mutant, p110, that functions independently of growth factor stimulation was constructed to determine the specific responses regulated by Pl-3 kinase. The p110 protein exhibited high specific activity as a Pl-3 kinase and as a protein kinase. Expression of p110 in NIH 3T3 cells induced transcription from the fos promoter. Co-expression of dominant negative Ras blocked this response. When expressed in Xenopus laevis oocytes, p110 increased the amount of guanosine 5'-triphosphate-bound Ras, caused activation of the Ras effector Raf-1, and induced Ras-dependent oocyte maturation. These findings show that Pl-3 kinase can stimulate diverse Ras-dependent cellular processes, including oocyte maturation and fos transcription.
Treatment of Hepatic Coma in Cirrhosis by Plasmapheresis and Plasma Infusion (Plasma Exchange) (1968)

Three patients with proved active fatty nutritional cirrhosis were treated with plasma exchange after at least 72 hr of refractory hepatic coma. In each case coma cleared after this treatment. The role of plasma exchange in hepatic coma is discussed.
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis (2001)

VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its fourth Ig domain, producing the murine Vcam1(D4D) allele. VCAM-1(D4D) mRNA and protein were reduced to 2-8% of wild-type allele (Vcam1(+)) levels but were sufficient to partially rescue the lethal phenotype of VCAM-1-null embryos. After crossing into the LDL receptor-null background, Vcam1(+/+) and Vcam1(D4D/D4D) paired littermates were generated from heterozygous intercrosses and fed a cholesterol-enriched diet for 8 weeks. The area of early atherosclerotic lesions in the aorta, quantified by en face oil red O staining, was reduced significantly in Vcam1(D4D/D4D) mice, although cholesterol levels, lipoprotein profiles, and numbers of circulating leukocytes were comparable to wild-type. In contrast, deficiency of ICAM-1 either alone or in combination with VCAM-1 deficiency did not alter nascent lesion formation. Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis.
SERUM 5α-DIHYDROTESTOSTERONE AND TESTOSTERONE CHANGES WITH AGE IN MAN (1976)

Serum 5alpha-dihydrotestosterone (DHT) and testosterone (T) were measured in 98 normal adult men aged between 20-80 years, separating T and DHT by thin layer chromatography and using a sensitive and reliable radio-immunoassay. In three age groups between 20-40, 40-60 and 60-80, the means +/- SEM for serum DHT were 84 +/- 4, 79 +/- 3 and 67 +/- 3 (ng/100 ml) respectively. The corresponding values for testosterone were 559 +/- 25, 491 +/- 25 and 475 +/- 28 (ng/100 ml). A significant decrease was observed in the DHT level of the 60-80 years age group compared to either the 20-40 (P less than 0.01) or the 40-60 (P less than 0.02) age groups. There was a moderate decline in the testosterone level of the 60-80 years age group compared to 20-40 years (P less than 0.05) but there were no significant changes in the testosterone levels between other groups.
Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons (2017)

Recent advances suggest that in vivo reprogramming of endogenous cell populations provides a viable alternative for neuron replacement. Astrocytes and oligodendrocyte precursor cells can be induced to transdifferentiate into neurons in the CNS, but, in these instances, reprogramming requires either transgenic mice or retroviral-mediated gene expression. We developed a microRNA (miRNA)-GFP construct that in vitro significantly reduced the expression of polypyrimidine tract-binding protein, and, subsequently, we packaged this construct in a novel oligodendrocyte preferring adeno-associated virus vector. Ten days after rat striatal transduction, the vast majority of the GFP-positive cells were oligodendrocytes, but 6 weeks to 6 months later, the majority of GFP-positive cells exhibited neuronal morphology and co-localized with the neuronal marker NeuN. Patch-clamp studies on striatal slices established that the GFP-positive cells exhibited electrophysiological properties indicative of mature neurons, such as spontaneous action potentials and spontaneous inhibitory postsynaptic currents. Also, 3 months after striatal vector administration, GFP-positive terminals in the ipsilateral globus pallidus or substantia nigra retrogradely transported fluorescent beads back to GFP-positive striatal cell bodies, indicating the presence of functional presynaptic terminals. Thus, this viral vector approach provides a potential means to harness resident oligodendrocytes as an endogenous source for in vivo neuronal replacement.
Chemistry and applications of nanocrystalline cellulose and its derivatives: A nanotechnology perspective (2011)

Abstract Nanocrystalline cellulose (NCC) is an emerging renewable nanomaterial that holds promise in many different applications, such as in personal care, chemicals, foods, pharmaceuticals, etc. By appropriate modification of NCC, various functional nanomaterials with outstanding properties, or significantly improved physical, chemical, biological, as well as electronic properties can be developed. The nanoparticles are stabilised in aqueous suspension by negative charges on the surface, which are produced during the acid hydrolysis process. NCC suspensions can form a chiral nematic ordered phase beyond a critical concentration, i.e. NCC suspensions transform from an isotropic to an anisotropic chiral nematic liquid crystalline phase. Due to its nanoscale dimension and intrinsic physicochemical properties, NCC is a promising renewable biomaterial that can be used as a reinforcing component in high performance nanocomposites. Many new nanocomposite materials with attractive properties were obtained by the physical incorporation of NCC into a natural or synthetic polymeric matrix. Simple chemical modification on NCC surface can improve its dispersability in different solvents and expand its utilisation in nano‐related applications, such as drug delivery, protein immobilisation, and inorganic reaction template. This review paper provides an overview on this emerging nanomaterial, focusing on the surface modification, properties and applications of NCC.
Expanding Window Fountain codes for scalable video multicast (2008)

Digital Fountain (DF) codes have recently been suggested as an efficient forward error correction (FEC) solution for video multicast to heterogeneous receiver classes over lossy packet networks. However, to adapt DF codes to low-delay constraints and varying importance of scalable multimedia content, unequal error protection (UEP) DF schemes are needed. Thus, in this paper, Expanding Window Fountain (EWF) codes are proposed as a FEC solution for scalable video multicast. We demonstrate that the design flexibility and UEP performancemake EWF codes ideally suited for this scenario, i.e., EWF codes offer a number of design parameters to be “tuned” at the server side to meet the different reception conditions of heterogeneous receivers. Performance analysis of H.264 Scalable Video Coding (SVC) multicast to heterogeneous receiver classes confirms the flexibility and efficiency of the proposed EWF-based FEC solution.
ChemInform Abstract: INTRODUCTION OF 3‐INDOLYLMETHYL RESIDUES INTO NITROACETIC ACID ESTERS (1978)

Abstract Aus den Mannichbasen (I) und den Nitro‐essigsäureestern (II) erhält man Ester der β‐(3‐Indolyl)‐a‐nitropropionsäure (IIIa) und (IIIb) bzw. β‐(3‐IndolyD‐β‐alkyl(aryl)‐a‐nitropropionsäure (IIIc)‐(IIIe).
Reactivity and mechanism of hydrolysis of phosphonamides (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactivity and mechanism of hydrolysis of phosphonamidesJubrail Rahil and Paul HaakeCite this: J. Am. Chem. Soc. 1981, 103, 7, 1723–1734Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/ja00397a024https://doi.org/10.1021/ja00397a024research-articleACS PublicationsRequest reuse permissionsArticle Views789Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
On the Independence of k Sets of Normally Distributed Statistical Variables (1935)

IN SUCH fields of investigation as economics, psychology, and anthropology, where observations on several variables are taken into account simultaneously, it is at least as important to study relationships among the variables as to consider the variables separately. In fact, if there are significant relationships within a system of variables, a considerable part of the information furnished by the observations will be lost unless the relationships are taken into account. In general, very little is known a priori about such a set of variables, and hence our knowledge of them and their various interrelations must be inferred from observations. Questions relating to the problem of making inferences from observations resolve themselves into those of, (1) devising suitable functions of the observations for estimating parameters which characterize the hypothetical population of the variables and (2) determining frequency laws from which the degree of credibility to be placed in the departure of these functions from expectation can be evaluated. The more complicated the hypothesis concerning the interrelations of the variables, the more complex, of course, will be the functions of observations for measuring the relationships and testing the hypothesis. It frequently happens in multivariate analysis that a number of variables can be rationally classed into several mutually exclusive categories. For example, certain measurable traits of individuals may be classed as physical or mental. In the study of wholesale prices of farm products in a certain region over a certain period of time, the products may be classed as (1) fruits, (2) vegetables, or (3) dairy products, and the deviations of the prices of products within each group from seasonal and secular trends may be taken as the variables. When variables can be grouped in such a manner the question naturally arises as to whether or not there is any significant relationship between the groups of variables. That is, on the basis of the available observations, with what degree of credibility can we assert that the groups are mutually independent, so that knowledge relative to one of the groups gives us no significant information about the others? If they are significantly non-independent how can we measure the amount of dependence? It will become apparent as we proceed that statistical functions' and significance tests more general and comprehensive than I See R. Frisch, Correlation and Scatter in Statistical Variables, Nordielk
Effects of Oral Morphine on Breathlessness and Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease (1989)

Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
Myeloperoxidase-Halide-Hydrogen Peroxide Antibacterial System (1968)

An antibacterial effect of myeloperoxidase, a halide, such as iodide, bromide, or chloride ion, and H(2)O(2) on Escherichia coli or Lactobacillus acidophilus is described. When L. acidophilus was employed, the addition of H(2)O(2) was not required; however, the protective effect of catalase suggested that, in this instance, H(2)O(2) was generated by the organisms. The antibacterial effect was largely prevented by preheating the myeloperoxidase at 80 C or greater for 10 min or by the addition of a number of inhibitors; it was most active at the most acid pH employed (5.0). Lactoperoxidase was considerably less effective than was myeloperoxidase when chloride was the halide employed. Myeloperoxidase, at high concentrations, exerted an antibacterial effect on L. acidophilus in the absence of added halide, which also was temperature- and catalase-sensitive. Peroxidase was extracted from intact guinea pig leukocytes by weak acid, and the extract with peroxidase activity had antibacterial properties which were similar, in many respects, to those of the purified preparation of myeloperoxidase. Under appropriate conditions, the antibacterial effect was increased by halides and by H(2)O(2) and was decreased by catalase, as well as by cyanide, azide, Tapazole, and thiosulfate. This suggests that, under the conditions employed, the antibacterial properties of a weak acid extract of guinea pig leukocytes is due, in part, to its peroxidase content, particularly if a halide is present in the reaction mixture. A heat-stable antibacterial agent or agents also appear to be present in the extract.
Frequency distributions of punctuation marks in English (2018)

The analysis of punctuation in philology is mainly carried out with a view to better understand the meaning of the literature concerned. Punctuation is generally believed to play the role of ‘assisting the written language in indicating those elements of speech that cannot be conveniently set down on paper: chiefly the pause, pitch and stress in speech’ (Markwardt, 1942: 156). Most of us often ignore the importance of punctuation in writing systems and tend to believe that punctuation only depends on tradition and the personal styles of writers. In fact, punctuation marks may contribute significantly to the clarity of expression. Many linguists associate punctuation with intonation, but the truth is more complex than that – punctuation marks may affect orthography, morphology, syntactic relations, semantic information, and can even influence textual structure.
Helix–hairpin–helix motifs confer salt resistance and processivity on chimeric DNA polymerases (2002)

Helix-hairpin-helix (HhH) is a widespread motif involved in sequence-nonspecific DNA binding. The majority of HhH motifs function as DNA-binding modules with typical occurrence of one HhH motif or one or two (HhH)(2) domains in proteins. We recently identified 24 HhH motifs in DNA topoisomerase V (Topo V). Although these motifs are dispensable for the topoisomerase activity of Topo V, their removal narrows the salt concentration range for topoisomerase activity tenfold. Here, we demonstrate the utility of Topo V's HhH motifs for modulating DNA-binding properties of the Stoffel fragment of TaqDNA polymerase and Pfu DNA polymerase. Different HhH cassettes fused with either NH(2) terminus or COOH terminus of DNA polymerases broaden the salt concentration range of the polymerase activity significantly (up to 0.5 M NaCl or 1.8 M potassium glutamate). We found that anions play a major role in the inhibition of DNA polymerase activity. The resistance of initial extension rates and the processivity of chimeric polymerases to salts depend on the structure of added HhH motifs. Regardless of the type of the construct, the thermal stability of chimeric Taq polymerases increases under the optimal ionic conditions, as compared with that of TaqDNA polymerase or its Stoffel fragment. Our approach to raise the salt tolerance, processivity, and thermostability of Taq and Pfu DNA polymerases may be applied to all pol1- and polB-type polymerases, as well as to other DNA processing enzymes.