gebhart/patrepeval huggingface dataset:
Copolymerization of propylene with higher α‐olefins in the presence of the syndiospecific catalyst i‐Pr(Cp)(9‐Flu)ZrCl2/MAO (2001)

Abstract The catalyst system i ‐Pr(Cp)(9‐Flu)ZrCl 2 /methylaluminoxane was used for the synthesis of random syndiotactic copolymers of propylene with 1‐hexene, 1‐dodecene, and 1‐octadecene as comonomers. An investigation of the microstructure by 13 C NMR spectroscopy revealed that the stereoregularity of the copolymers decreased because of an increase in skipped insertions in the presence of the higher 1‐olefin. The melting temperature of the copolymers, as measured by differential scanning calorimetry (DSC), decreased linearly with increasing comonomer content independently of the comonomer nature. During the DSC heating cycle, an exothermic peak indicating a crystallization process was observed. The decrease in the crystallization temperature with higher 1‐olefin content, measured by crystallization analysis fractionation, indicated a small but significant dependence on the nature of the comonomer. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part A: Polym Chem 40: 128–140, 2002
Differential Segmental Flexibility and Reach Dictate the Antigen Binding Mode of Chimeric IgD and IgM: Implications for the Function of the B Cell Receptor (2004)

Mature, naive B cells coexpress IgD and IgM with identical binding sites. In this study, the binding properties of such IgM and IgD are compared to determine how size and shape may influence their ability to bind Ag and thus function as receptors. To dissect their intrinsic binding properties, recombinant IgM and IgD were produced in soluble form as monomers of the basic H(2)L(2) Ab architecture, each with two Ag binding sites. Since these sites are connected with a hinge region in IgD and structural Ig domains in IgM, the two molecules differ significantly in this region. The results show that IgD exhibited the larger angle and longer distance between its binding sites, as well as having the greater flexibility. Relative functional affinity was assessed on two antigenic surfaces with high or low epitope density, respectively. At high epitope density, IgM had a higher functional affinity for the Ag compared with IgD. The order was reversed at low epitope density due to a decrease in the functional affinity of IgM. Studies of binding kinetics showed similar association rates for both molecules. The dissociation rate, however, was slower for IgM at high epitope density and for IgD at low epitope density. Taken together, the results show that IgM and IgD with identical Ag binding regions have different Ag binding properties.
International Cryogenic Engineering Conference (4th) Held at Eindhiven, Netherlands, on May 24-26 1972 (1972)

Abstract : ;Contents: Uses of low temperatures; Materials; Ac losses in superconductors; Superconducting, Magnets; Energy storage and transmission; Ultra low temperatures; Superconducting levitation.
A Multitargeted, Metronomic, and Maximum-Tolerated Dose “Chemo-Switch” Regimen is Antiangiogenic, Producing Objective Responses and Survival Benefit in a Mouse Model of Cancer (2004)

This study demonstrates a potentially tractable clinical strategy in a stringent preclinical model, wherein standard-of-care chemotherapy is followed by a novel maintenance regimen: PDFGR is targeted to disrupt pericyte support, while metronomic chemotherapy and/or VEGFR inhibitors target consequently sensitized endothelial cells, collectively destabilizing pre-existing tumor vasculature and inhibiting ongoing angiogenesis.
Human bocavirus—the first 5 years (2011)

Four species of human bocavirus (HBoV) have been recently discovered and classified in the Bocavirus genus (family Parvoviridae, subfamily Parvovirinae). Although detected both in respiratory and stool samples worldwide, HBoV1 is predominantly a respiratory pathogen, whereas HBoV2, HBoV3, and HBoV4 have been found mainly in stool. A variety of signs and symptoms have been described in patients with HBoV infection including rhinitis, pharyngitis, cough, dyspnea, wheezing, pneumonia, acute otitis media, fever, nausea, vomiting, and diarrhea. Many of these potential manifestations have not been systematically explored, and they have been questioned because of high HBoV co-infection rates in symptomatic subjects and high HBoV detection rates in asymptomatic subjects. However, evidence is mounting to show that HBoV1 is an important cause of lower respiratory tract illness. The best currently available diagnostic approaches are quantitative PCR and serology. This concise review summarizes the current clinical knowledge on HBoV species.
Structure and Mechanism of MbtI, the Salicylate Synthase from Mycobacterium tuberculosis (2007)

MbtI (rv2386c) from Mycobacterium tuberculosis catalyzes the initial transformation in mycobactin biosynthesis by converting chorismate to salicylate. We report here the structure of MbtI at 2.5 A resolution and demonstrate that isochorismate is a kinetically competent intermediate in the synthesis of salicylate from chorismate. At pH values below 7.5 isochorismate is the dominant product while above this pH value the enzyme converts chorismate to salicylate without the accumulation of isochorismate in solution. The salicylate and isochorismate synthase activities of MbtI are Mg2+-dependent, and in the absence of Mg2+ MbtI has a promiscuous chorismate mutase activity similar to that of the isochorismate pyruvate lyase, PchB, from Pseudomonas aeruginosa. MbtI is part of a larger family of chorismate-binding enzymes descended from a common ancestor (the MST family), that includes the isochorismate synthases and anthranilate synthases. The lack of active site residues unique to pyruvate eliminating members of this family, combined with the observed chorismate mutase activity, suggests that MbtI may exploit a sigmatropic pyruvate elimination mechanism similar to that proposed for PchB. Using a combination of structural, kinetic, and sequence based studies we propose a mechanism for MbtI applicable to all members of the MST enzyme family.
Drug Delivery: Principles and Applications (2005)

Preface. List of Contributors. 1. Factors that Impact the Developability of Drug Candidates-An Overview (Chao Han and Binghe Wang). 2. Chemical, Biochemical, and Physiological Barriers to Oral Drug Delivery (Teruna Siahaan). 3. Pathways for Drug Delivery to the Central Nervous System (Yan Zhang and Donald W. Miller). 4. Physiochemical Properties, Formulation and Drug Delivery (E. Munson). 5. Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery (William F. Elmquist). 6. Pre-Systemic and First-pass Metabolism (W. Griffith Humphreys). 7. Cell Culture Models for Drug Transport Studies (D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasabdabi, Amber M. Young, Erik Rytting, Bradley Yops and Kenneth L. Audus). 8. Prodrug Approaches to Drug Delivery (Longqin Hu). 9. Receptor-Mediated Drug Delivery (Chirstopher P. Leamon and Philip S. Low). 10. Oral Protein and Peptide Drug Delivery (Rick Soltero). 11. Metabolic Activation and Drug Targeting (Xiangming Guan). 12. Ultrasound Mediated Drug Delivery (Ka-yun Ng' and Terry O. Matsunaga). 13. Polycationic Peptides and Proteins in Drug Delivery: Focus on Non-Classical Transport (Lisa A. Kueltzo and C. Russell Middaugh). 14. Gene Therapy and Gene Delivery (Naoki Kobayashi, Makiya Nishikawa and Yoshinobu Takakura). 15. Parenteral Formulations for Peptide and Protein Delivery, and Monoclone Antibody Drugs (John Bontempo). 16. Pulmonary Drug Delivery - Pharmaceutical Chemistry and Aerosol Technology (Anthony J. Hickey). 17. Antibody-Directed Drug Delivery (Herve Le Calvez, John Mountzouris, Kosi Gramatikoff and Fang Fang). 18. Efflux Transporters in Drug Excretion (Shuzhong Zhang and Marilyn E. Morris). 19. Liposome as Drug Delivery Vehicles (Guijun Wang). 20. Regulatory and IP Issues in Drug Delivery Research (Shihong Nicolaou). Index.
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma (2002)

Trans-4-hydroxy-2-nonenal (4-HNE), a major electrophilic by-product of lipid peroxidation, is able to interact with DNA to form exocyclic guanine adducts. 4-HNE is a mutagen and a significant amount of 4-HNE-guanine adduct has been detected in normal cells. Recently, it has been reported that exposure of the wild-type p53 human lymphoblastoid cell line to 4-HNE causes a high frequency of G to T transversion mutations at the third base of codon 249 (-AGG*-) in the p53 gene, a mutational hotspot in human cancers, particularly hepatocellular carcinoma. These findings raise a possibility that 4-HNE could be an important etiological agent for human cancers that have a mutation at codon 249 of the p53 gene. However, to date, the sequence specificity of 4-HNE-DNA binding remains unclear due to the lack of methodology. To address this question, we have developed a method, using UvrABC nuclease, a nucleotide excision repair enzyme complex isolated from Escherichia coli, to map the distribution of 4-HNE-DNA adducts in human p53 gene at the nucleotide sequence level. We found that 4-HNE-DNA adducts are preferentially formed at the third base of codon 249 in the p53 gene. The preferential binding of 4-HNE was also observed at codon 174, which has the same sequence and the same nearest neighbor sequences (-GAGG*C-) as codon 249. These results suggest that 4-HNE may be an important etiological agent for human cancers that have a mutation at codon 249 of the p53 gene.
Recombinant Fusion Toxins Directed Against the Human Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Receptor (2003)

Acute myeloid leukemia (AML) has an annual incidence of 2.4 cases per 100,000 persons and is the most common form of acute leukemia in adults (, ). AML is a model for drug-resistant human cancers, and current therapies for AML possess a narrow therapeutic margin. The use of high-dose and intensive chemotherapy regimens produces remission in the majority of patients with AML; however, most cases subsequently relapse and eventually succumb to chemotherapy-refractory disease (, ). Attempts to further increase chemotherapy dose intensity in AML treatment regimens often result in an increased incidence of therapy-related morbidity and mortality.
Reversible molecular photoswitches: A key technology for nanoscience and fluorescence imaging (2005)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Preparation of hydrogel beads from crosslinked poly(methyl methacrylate) microspheres by alkaline hydrolysis (1990)

Abstract Poly(methyl methacrylate)/(PMMA) microspheres crosslinked with various concentrations of ethylene glycol dimethacrylate (EGDM) were prepared by a suspension polymerization procedure. They were subjected to alkaline hydrolysis in ethylene glycol at high temperature (&gt; 175°C), resulting in the rapid conversion of methacrylate ester functions to methacrylic acid, while retaining the spherical shape of the microspheres intact. The method provides a novel approach to obtain smooth, nearly perfect spherical, mechanically strong, high water‐absorbing hydrogel beads from crosslinked PMMA. The reaction has been found to be considerably faster than many of the hydrolysis procedures reported previously. The effect of concentration of alkali, particle size, crosslinking density, and reaction time on the extent of hydrolysis has been investigated to a limited extent.
Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia (2022)

Blocking the pyrimidine nucleotide <i>de novo</i> synthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH) results in the cell cycle arrest and/or differentiation of rapidly proliferating cells including activated lymphocytes, cancer cells, or virally infected cells. Emvododstat (PTC299) is an orally bioavailable small molecule that inhibits DHODH. We evaluated the potential for emvododstat to inhibit the progression of acute myeloid leukemia (AML) using several <i>in vitro</i> and <i>in vivo</i> models of the disease. Broad potent activity was demonstrated against multiple AML cell lines, AML blasts cultured ex vivo from patient blood samples, and AML tumor models including patient-derived xenograft models. Emvododstat induced differentiation, cytotoxicity, or both in primary AML patient blasts cultured ex vivo with 8 of 10 samples showing sensitivity. AML cells with diverse driver mutations were sensitive, suggesting the potential of emvododstat for broad therapeutic application. AML cell lines that are not sensitive to emvododstat are likely to be more reliant on the salvage pathway than on <i>de novo</i> synthesis of pyrimidine nucleotides. Pharmacokinetic experiments in rhesus monkeys demonstrated that emvododstat levels rose rapidly after oral administration, peaking about 2 hours post-dosing. This was associated with an increase in the levels of dihydroorotate (DHO), the substrate for DHODH, within 2 hours of dosing indicating that DHODH inhibition is rapid. DHO levels declined as drug levels declined, consistent with the reversibility of DHODH inhibition by emvododstat. These preclinical findings provide a rationale for clinical evaluation of emvododstat in an ongoing Phase 1 study of patients with relapsed/refractory acute leukemias.
Growth hormone (GH)-releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus? (2008)

Although growth hormone (GH) is primarily associated with linear growth in childhood, it continues to have important metabolic functions in adult life. Adult GH deficiency (AGHD) is a distinct clinical entity, and GH replacement in AGHD can improve body composition, strength, aerobic capacity, and mood, and may reduce vascular disease risk. While there are some hormone-related side effects, the balance of benefits and risks is generally favorable, and several countries have approved GH for clinical use in AGHD. GH secretion declines progressively and markedly with aging, and many age-related changes resemble those of partial AGHD. This suggests that replacing GH, or stimulating GH with GH-releasing hormone or a GH secretagogue could confer benefits in normal aging similar to those observed in AGHD--in particular, could reduce the loss of muscle mass, strength, and exercise capacity leading to frailty, thereby prolonging the ability to live independently. However, while most GH studies have shown body composition effects similar to those in AGHD, functional changes have been much less inconsistent, and older adults are more sensitive to GH side effects. Preliminary reports of improved cognition are encouraging, but the overall balance of benefits and risks of GH supplementation in normal aging remains uncertain.
Sensitization of tumor cells to Apo2 ligand/TRAIL-induced apoptosis by inhibition of casein kinase II. (2002)

Tumor-cell death can be triggered by engagement of specific death receptors with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL). Apo2L/TRAIL-induced apoptosis involves caspase-8-mediated cleavage of BID. The active truncated form of BID (tBID) triggers the mitochondrial activation of caspase-9 by inducing the activation of BAK or BAX. Although a broad spectrum of human cancer cell lines express death receptors for Apo2L/TRAIL, many remain resistant to TRAIL/Apo2L-induced death. A variety of human cancers exhibit increased activity of casein kinase II (CK2). Here we demonstrate that CK2 is at the nexus of two signaling pathways that protect tumor cells from Apo2L/TRAIL-induced apoptosis. We find that CK2 inhibits Apo2L/TRAIL-induced caspase-8-mediated cleavage of BID, thereby reducing the formation of tBID. In addition, CK2 promotes nuclear factor kappa B (NF-kappa B)-mediated expression of Bcl-x(L), which sequesters tBID and curtails its ability to activate BAX. Tumor cells with constitutive activation of CK2 exhibit a high Bcl-x(L)/tBID ratio and fail to activate caspase-9 or undergo apoptosis in response to Apo2L/TRAIL. Conversely, reduction of the Bcl-x(L)/tBID ratio by inhibition of CK2 renders such cancer cells sensitive to Apo2L/TRAIL-induced activation of caspase-9 and apoptosis. Using isogenic cancer cell lines that differ only in the presence or absence of either the p53 tumor suppressor or the BAX gene, we show that the enhancement of Apo2L/TRAIL-induced tumor-cell death by CK2 inhibitors requires BAX, but not p53. The identification of CK2 as a key survival signal that protects tumor cells from death-receptor-induced apoptosis could aid the design of Apo2L/TRAIL-based combination regimens for treatment of diverse cancers.
III-nitride blue microdisplays (2001)

Prototype blue microdisplays have been fabricated from InGaN/GaN quantum wells. The device has a dimension of 0.5×0.5 mm2 and consists of 10×10 pixels 12 μm in diameter. Emission properties such as electroluminescence spectra, output power versus forward current (L–I) characteristic, viewing angle, and uniformity have been measured. Due to the unique properties of III-nitride wide-band-gap semiconductors, microdisplays fabricated from III nitrides can potentially provide unsurpassed performance, including high-brightness/resolution/contrast, high-temperature/high-power operation, high shock resistance, wide viewing angles, full-color spectrum capability, long life, high speed, and low-power consumption, thus providing an enhancement and benefit to the present capabilities of miniature display systems.
Perfluorochemicals as gastrointestinal contrast agents for MR imaging: preliminary studies in rats and humans (1987)

The ability to distinguish bowel from other intraabdominal structures is essential for the accurate diagnosis of intraabdominal disease with MR. Because perfluorochemicals have no protons, they cause no MR signal. Since they are immiscible with water, they create a signal void in bowel independent of bowel contents and thus are suitable as oral contrast agents. Furthermore, they are tasteless and odorless and have no side effects. We evaluated the use of perfluorochemicals by performing MR scans of the abdomen in rats after the oral administration of unemulsified perfluorohexylbromide or perfluoroctylbromide. Since the latter is approved as an investigational drug for oral use in humans, two volunteers were also studied. Both compounds created signal void in the bowel of both rats and human subjects allowing identification of the gastrointestinal tract. The results suggest that these compounds have potential as oral contrast agents for MR imaging.
Short syntheses of furan and catechol derivatives. A synthesis of hydrourushiol (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShort syntheses of furan and catechol derivatives. A synthesis of hydrourushiolErnest Wenkert, Miguel E. Alonso, Brian L. Buckwalter, and Eduardo L. SanchezCite this: J. Am. Chem. Soc. 1983, 105, 7, 2021–2029Publication Date (Print):April 1, 1983Publication History Published online1 May 2002Published inissue 1 April 1983https://pubs.acs.org/doi/10.1021/ja00345a059https://doi.org/10.1021/ja00345a059research-articleACS PublicationsRequest reuse permissionsArticle Views1245Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
女性主义、法律改革和中东北非的妇女赋权运动：研究、实践和政策相结合 (2008)

歧视的代价 学术研究和政策研究都指出中东北非（MENA）地区存在长期的性别不平等,成为经济和人类发展的障碍。十年前,学者们认为妇女对劳动力的低参与阻碍了经济发展,也妨害了妇女参与社会（Khoury and Moghadam,1995）。近期的一项研究表明,由于妇女在劳动力中代表不足,中东北非国家无力应对全球化的挑战（Karshenas,2001）。《2002年阿拉伯人类发展报告》完全由阿拉伯学者撰写,是一个里程碑式的系列中的第一步。
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR (1996)

Mutant-enriched PCR was applied to the detection of mutations at codons 12 and 13 of K-ras genes in the stools of patients with colorectal cancer. Mutations were analyzed in stool samples obtained prior to surgery. Resected tumor specimens were screened for K-ras mutations by PCR-mediated RFLP analysis. Using normal stool samples, assay conditions were adjusted to optimal sensitivity and specificity. The following specimens were included in the study: 16 stool samples corresponding to carcinomas in which K-ras mutations had been identified; 7 randomly selected stool samples corresponding to carcinomas which were negative for K-ras mutations; 1 stool sample from a patient with non-Hodgkin's lymphoma. In 13 of the 16 stool samples (81%) corresponding to tumors in which K-ras mutations had been identified previously, K-ras mutations were detected. In 2 of the 7 stool samples corresponding to tumors in which K-ras mutations had not been detected by previous PCR-mediated RFLP analysis, K-ras mutations were also present. Reanalyses of the tumors corresponding to these 2 positive stool samples by mutant-enriched PCR revealed a K-ras mutation in one of the tumors. The stool and tumor of the patient with non-Hodgkins lymphoma were negative for K-ras mutations. DNA sequence analysis revealed that, for each of the K-ras mutations identified in stool samples, identical base substitutions were present in the corresponding tumor tissue. The results indicate that tumor cells harboring K-ras mutations can be detected in the stools of patients with colorectal cancer by mutant-enriched PCR with high sensitivity and specificity. Because of the simplicity of the technique, it may be suitable for screening of stool samples for mutations of the K-ras gene.
Power control schemes for TDD systems with multiple transmit and receive antennas (2003)

This paper investigates the performance of narrowband, slowly-fading, and delay-limited multiple-antenna systems where channel state information (CSI) is available at the transmission end. This situation can arise in time-division duplex (TDD) based two-way systems where channel state estimation can be performed using the signal received from the opposite link. Power control methods which attempt to keep the transmission rate constant at the expense of randomizing the transmit power are considered. It is shown that significant savings in the average transmit power (sometimes on the order of tens of dB) can be expected compared to systems which keep the total transmit power constant. Several practical channel coding examples are illustrated and their bit and frame error rate performance are discussed.
Fredericksz Transition Threshold in Nematic Liquid Crystals Filled with Ferroelectric Nano-Particles (2006)

A key liquid crystalline property for electro-optic applications is the Frederiks threshold electric field. There has been recent experimental interest in liquid crystal-based colloidal suspensions in which the colloidal nanoparticles both possess a permanent electric polarization and provide strong director anchoring on the particle surface. Such suspensions are sometimes known as Filled Liquid Crystals. Our calculations suggest, in qualitative agreement with experiment, that filling the nematic liquid crystal with ferroelectric nanoparticles can significantly decrease the electric Frederiks transition threshold field.