gebhart/patrepeval huggingface dataset:
One- and two-laser photochemistry of iminodibenzyl (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOne- and two-laser photochemistry of iminodibenzylZ. Wang and W. G. McGimpseyCite this: J. Phys. Chem. 1993, 97, 38, 9668–9672Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/j100140a023https://doi.org/10.1021/j100140a023research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
DAB486IL‐2 fusion toxin in refractory rheumatoid arthritis (1993)

The results of this open trial provide preliminary evidence for a potential therapeutic effect of DAB486IL-2 in RA, with an acceptable safety profile. Reversible transaminase elevations limit escalation of the dosage beyond 0.1 mg/kg/day. A controlled study of DAB486IL-2 is required to determine the efficacy of this high-affinity IL-2R-targeted fusion toxin in the treatment of RA.
Impact of the 3,6,9-Trioxadecyloxy Group on Desazadesferrithiocin Analogue Iron Clearance and Organ Distribution (2007)

The impact of introducing a 3,6,9-trioxadecyloxyl group at various positions of the desazadesferrithiocin (DADFT) aromatic ring on iron clearance and organ distribution is described. Three DADFT polyethers are evaluated: (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-4'-(HO)-DADFT-PE, 3], (S)-4,5-dihydro-2-[2-hydroxy-5-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-5'-(HO)-DADFT-PE, 6], and (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-3'-(HO)-DADFT-PE, 9]. The iron-clearing efficiency (ICE) in rodents and primates is shown to be very sensitive to which positional isomer is evaluated, as is the organ distribution in rodents. The polyethers had uniformly higher ICEs than their corresponding parent ligands in rodents, consistent with in vivo ligand-serum albumin binding studies. Ligand 9 is the most active polyether analogue in rodents and is also very effective in primates, suggesting a higher index of success in humans. In addition, this analogue is also shown to clear more iron in the urine of the primates than many of the other chelators. If this trend were also observed in patients, it would facilitate iron-balance studies in a clinical setting.
Outpost Reference : Meeting Patrons on Their Own Ground (2007)

This article discusses the creation of an outpost reference service as well as a roving reference project.
GitBAC: Flexible access control for non-modular concerns (2011)

Today's techniques for controlling access to software artifacts are limited to restricting access to whole files and directories. But when a company's access control policy does not match a project's existing physical modularization, these techniques require either an all-or-nothing approach or re-modularization of the files and directories. The increased maintenance overhead this brings to project administration can lead to unimplemented or insufficient developer access control and an increased risk of insider security incidents (e.g., theft of intellectual property). We have created a tool (GitBAC) to provide access control of software artifacts using a crosscutting concern instead of artifact modularization. Our method provides fine-grained access control of artifacts and accommodates flexible access control policies.
Experiment-Driven Characterization of Full-Duplex Wireless Systems (2012)

We present an experiment-based characterization of passive suppression and active self-interference cancellation mechanisms in full-duplex wireless communication systems. In particular, we consider passive suppression due to antenna separation at the same node, and active cancellation in analog and/or digital domain. First, we show that the average amount of cancellation increases for active cancellation techniques as the received self-interference power increases. Our characterization of the average cancellation as a function of the self-interference power allows us to show that for a constant signal-to-interference ratio at the receiver antenna (before any active cancellation is applied), the rate of a full-duplex link increases as the self-interference power increases. Second, we show that applying digital cancellation after analog cancellation can sometimes increase the self-interference, and thus digital cancellation is more effective when applied selectively based on measured suppression values. Third, we complete our study of the impact of self-interference cancellation mechanisms by characterizing the probability distribution of the self-interference channel before and after cancellation.
Handbook Of Liquid Crystal Research (1997)

The last twenty-five years has seen enormous advances in both our imderstanding of liquid crystals and our ability to use them in applications.Early on during this period, it was possible for a person working in the field to be aware of most of the results, both pure and applied.Midway through this period, it was still feasible to compile a bibliography of aU the scientific work done on liquid crystals.The situation is vastly different now: the sheer volume of what has been published in the field of liquid crystals makes any attempt to assemble an exhaustive summary impractical.Yet it is extremely important that scientists and engineers working in one area of the liquid crystal field have ready access to what is known and what has been accomplished in other areas of the field.Likewise, people either considering working with liquid crystals or just starting to work with liquid crystals must be able to learn about the most important developments of this twenty-five-year period.For these two reasons, we have asked twenty-one scientists with extensive experience in different areas of liquid crystal research to write chapters detailing the most important and valuable advances in their areas.Since the progress made during this period has been both scientific and technological, we have collected an equal number of chapters emphasizing each.The authors have not attempted to make their chapters truly comprehensive; instead, they have concentrated on those results that have been most important in either advancing our knowledge and opening up possibilities for applications.They have also emphasized work done in the last fifteen years and developments that have helped to both simplify and elucidate the phenomena.The result is a volume encompassing a huge amoimt of material with references to thousands of publica tions.Rather than being a summary, however, it brings together those developments that have had the most lasting impact on the field.It is therefore a critical progress report of the state of liquid crystal research as we enter the twenty-first century.
Efficacy and Tolerability of Budesonide/Formoterol Added to Tiotropium in Patients with Chronic Obstructive Pulmonary Disease (2009)

In patients with chronic obstructive pulmonary disease, budesonide/formoterol added to tiotropium versus tiotropium alone provides rapid and sustained improvements in lung function, health status, morning symptoms and activities, and reduces severe exacerbations. Clinical trial registered with www.clinicaltrials.gov (NCT00496470).
Role of frontal cortex in social odor discrimination and scent-marking in female golden hamsters (Mesocricetus auratus). (1998)

Orbital/agranular insular (ORB/AI) cortex has been implicated in traditional olfactory learning tasks and social behavior but its precise role in discriminating-learning social odors is not known. Female golden hamsters received aspiration lesions of ORB/AI or dorsomedial (DM) frontal cortex and were tested for their ability to (a) discriminate between odors of individual males in a habituation-discrimination task, (b) show preferences for male over female odors, and (c) scent-mark in response to male odors. Lesioned females readily discriminated between scents of individual males. Neither lesion altered female preferences for male odors. Females with DM lesions showed increased levels of scent marking to male odors, but those with ORB/AI cortex lesions did not differ from controls. Thus, ORB/AI cortex does not appear to be critical for discrimination of odors of individuals or sex or for scent-marking responses based on these discriminations.
Ray Tracing Dynamic Scenes using fast KD-tree Base on Multi-Core Architectures (2008)

We present a simple and efficient algorithm for interactive ray tracing of dynamic Scenes using kd-tree base on multi-core architectures. Instead of alternating between phases of rendering and (potentially infrequent) building, our approach exploits the parallelism inherent in a multi-core system by continuously and asynchronously rebuilding new kd-tree (potentially over the course of multiple frames) while the remaining cores concurrently update and traverse the most recently built kd-tree. We do not make any assumptions about the possible deformation or motion of objects and dynamically update or rebuild the hierarchy depending on our simple heuristic.
Experimental Hydroxyapatite Cement Cranioplasty (1992)

Hydroxyapatite cement is a calcium phosphate-based material that when mixed with water forms a dense paste that sets within 15 minutes and isothermically converts in vivo to a microporous hydroxyapatite implant. This cement was used to reconstruct bilateral 2.5-cm-diameter full-thickness critical-sized parietal skull defects in six cats. One side was reconstructed with 100 percent hydroxyapatite cement, and the other with a mixture of 50 percent hydroxyapatite cement and 50 percent ground autogenous bone by weight. These animals were sacrificed at 6 and 12 months after implantation. Positive and negative controls also were prepared. The anatomic contour of the soft tissue overlying all hydroxyapatite cement implants was well maintained, there were no wound infections or structural failures, and the implants were well tolerated histologically. None of the negative (unreconstructed) control defects was completely filled with repair bone, and all positive (methyl methacrylate) controls demonstrated foreign-body giant-cell formation and fibrous encapsulation of the implants. Examination of decalcified and undecalcified sections revealed progressive but variable replacement of the cement by new bone and soft tissue without a change in the shape or volume of the hydroxyapatite cement-reconstructed areas. New bone comprised 77.3 and 64.7 percent of the tissue replacing the hydroxyapatite cement and hydroxyapatite cement-bone implants, respectively. Replacement of the hydroxyapatite cement implants by new bone is postulated to occur by a combination of osteoconduction and implant resorption. These results indicate that further experimental research leading to the possible application of hydroxyapatite cement for full-thickness calvarial defect reconstruction in humans is warranted.
MEK‐inhibitor U0126 in hyperglycaemic focal ischaemic brain injury in the rat (2008)

In conclusion, U0126 appears to be neuroprotective in this model of hyperglycaemic ischaemic brain injury. The findings support the pathogenic importance of the MEK-ERK pathway in hyperglycaemic-ischaemic brain injury.
Scalable Video Coding Using Compressive Sensing (2012)

Video coding using compressive video sensing exhibits many characteristics that are desirable for transmission in a video network. In particular, the coded video is inherently scalable with channel capacity, decoding complexity, display resolution, and quality. In this paper, we present compressive video sensing methods and demonstrate video scalability with such properties as graceful degradation, multi-resolution decoding. © 2012 Alcatel-Lucent.
Quantitative assessment of the noncovalent inhibition of sickle hemoglobin gelation by phenyl derivatives and other known agents (1979)

The ability of a variety of phenyl derivatives to inhibit sickle cell hemoglobin gelation was placed on a quantitative scale by parallel equilibrium and kinetic assays. Modifications of the phenyl ring studied include polar, nonpolar, and charged substituents, added aromatic rings, and loss of aromaticity. Other noncovalent inhibitors previously reported to have high potency were measured and placed on the same quantitative scale. Some phenyl derivatives were found to be as effective an any other known noncovalent antigelling agent. The phenyl compounds penetrate easily into red cells, and their potency is tolerant to chemical modification, which holds out the possibility of designing low-toxicity derivatives. On the negative side, the level of potency obtainable appears to be inadequate for clinical use. The best phenyl inhibitors display a functionally defined inhibitory constant (K1) of 75 mM, and it can be estimated that inhibitor concentrations over 20 mM would be necessary to obtain minimal clinically significant benefit. Furthermore, with the variety of modifications tested here, no impressive increase in activity could be achieved over that found in the simplest phenyl compounds.
Finite Element Simulation: Tensile test of rib cortical bone (2010)

Thoracic trauma is the principal causative factor in 30% of road traffic deaths [1]. And when 6 or more ribs are fractured, mortality rate and associated injuries to the head and thorax are increased significantly [2].
This thesis work was carried out to improve the understanding of the mechanical properties of the human rib. These properties are necessary in order to develop realistic finite element models of human chest which are used in the field of vehicle safety. The purpose of this study was to collect values for the rib mechanical properties obtained experimentally. And to compare the values of material properties of human rib cortical bone used in the FE simulation of THUMS with the material properties of human rib cortical bone of PMHS analyzed by Kemper et al. with a tensile test [3]. It has been simulated a tensile test of a specimen of cortical bone of the rib with a FEM in Ls Dyna. The cortical bone has considered a piecewise linear plasticity material and it has been simulated with shell elements. The specimen was loaded at a rate of 5 mm/s (0.5 strains/s). The results of the traction test have been compared with those of Kemper et al. realized on six PMHS. It has been observed that the FE model results are closer to the experimental results if strain rate parameters are not used.
Anti-interferon-gamma antibodies in the treatment of autoimmune diseases. (2003)

Interferon (IFN)-gamma is an important immune regulator in normal immunity. When IFN gamma production is disturbed, various autoimmune diseases (ADs) can develop, in which we suggest that anti-IFN gamma could have a beneficial effect. Depending on the cell type in which IFN gamma synthesis is disturbed, different clinical manifestations may result. We have also proposed to remove tumor necrosis factor (TNF)-alpha, together with certain types of IFNs, to treat various ADs and AIDS, also an autoimmune condition. Anti-IFN gamma has been tested in several T-helper cell (Th1) ADs, including rheumatoid arthritis (RA), multiple sclerosis (MS), corneal transplant rejection, uveitis, Type I diabetes, schizophrenia (anti-IFN gamma and anti-TNF alpha), and various autoimmune skin diseases (alopecia areata, psoriasis vulgaris, vitiligo, pemphigus vulgaris and epidermolysis bullosa). A strong, sometimes striking, therapeutic response followed administration of anti-IFN gamma, indicating that it may be a promising therapy for Th1 ADs.
Deficiency of the Cysteine Protease Cathepsin S Impairs Microvessel Growth (2003)

During angiogenesis, microvascular endothelial cells (ECs) secrete proteinases that permit penetration of the vascular basement membrane as well as the interstitial extracellular matrix. This study tested the hypothesis that cathepsin S (Cat S) contributes to angiogenesis. Treatment of cultured ECs with inflammatory cytokines or angiogenic factors stimulated the expression of Cat S, whereas inhibition of Cat S activity reduced microtubule formation by impairing cell invasion. ECs from Cat S-deficient mice showed reduced collagenolytic activity and impaired invasion of collagens type I and IV. Cat S-deficient mice displayed defective microvessel development during wound repair. This abnormal angiogenesis occurred despite normal vascular endothelial growth factor and basic fibroblast growth factor levels, implying an essential role for extracellular matrix degradation by Cat S during microvessel formation. These results demonstrate a novel function of endothelium-derived Cat S in angiogenesis.
Anti-Obesity and Antioxidative Effects of Purple Sweet Potato Extract in 3T3-L1 Adipocytes In Vitro (2011)

The purpose of the current study was to determine the anti-obesity and anti-inflammatory effects of an extract of purple sweet potatoes (PSPs) on 3T3-L1 adipocytes. For this purpose, differentiated 3T3-L1 adipocytes were treated with a PSP extract at concentrations of 1,000, 2,000, and 3,000 μg/mL for 24 hours. Then, we measured the changes in the sizes of the adipocytes, the secretion of leptin, and the mRNA/protein expression of lipogenic, inflammatory, and lipolytic factors after the treatment with the PSP extract. The PSP extract diminished leptin secretion, indicating that growth of fat droplets was suppressed. The extract also suppressed the expression of mRNAs of lipogenic and inflammatory factors and promoted lipolytic action. The antioxidative activity of the PSP extract was also measured using three different in vitro methods: 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity, ferric reducing ability potential assay, and chelating activity of transition metal ions. Taken together, our study shows that PSP extract has antilipogenic, anti-inflammatory, and lipolytic effects on adipocytes and has radical scavenging and reducing activity.
Antinociceptive Effect of Bupivacaine Encapsulated in Poly(D,L)-Lactide-Co-Glycolide Microspheres in the Acute Inflammatory Pain Model of Carrageenin-Injected Rats (1997)

Encapsulating bupivacaine in poly(D,L)-lactidecoglycolide microspheres may prolong analgesia and diminish systemic toxicity. The antinociceptive effect of bupivacaine-loaded microspheres (1, 2.5, and 5 mg) and plain bupivacaine solutions (1, 2.5, and 5 mg) were compared using the vocalization threshold to paw pressure test (VTPP) in rats. Local anesthetic solutions were injected subcutaneously in the plantar hindpaw. First, the biological inactivity of the vehicle and drug-free microspheres (DFM) was evaluated in normal (n = 8) or carrageenin-injected rats (n = 24). Second, onset of antinociception was evaluated in normal rats (n = 16). We then evaluated the duration of antinociception induced by the different local anesthetic solutions in carrageenin-injected rats (n = 56). Neither the vehicle nor the DFM induced any modification of the VTPP. Onset of antinociception was 5 min for all local anesthetic solutions. Duration of antinociception was 60 min with plain bupivacaine (1 mg) and increased to 90, 120, and 180 min, respectively, for the different doses of bupivacaine-loaded microspheres (1, 2.5, and 5 mg). Larger doses of plain bupivacaine (2.5 and 5 mg) induced systemic toxicity. The encapsulation of bupivacaine in microspheres induced a dose-dependent increase in duration of antinociception as compared with plain bupivacaine. (Anesth Analg 1997;84:90-4)
Phenotypic and Cytogenetic Characterization of Human Bladder Urothelia Expanded in Vitro (1994)

A simple method for the harvest of bladder cell types from surgical specimens was used to generate strains of normal human urothelial cells that could be reproducibly cultivated, passaged and extensively expanded in serum-free medium. Immunostaining of the bladder epithelial cells with broadly reacting anti-cytokeratin antibodies and with an anti-cytokeratin antibody specific to cytokeratin 7, a transitional cell marker, indicated that they expressed a stable epithelial phenotype with serial passage. Low levels of immunostaining for E-cadherin and low levels of E-cadherin messenger ribonucleic acid, as determined by Northern blot analysis, and strongly positive immunostaining with an anti-vimentin antibody indicated collectively that the uroepithelial cells express a nonbarrier-forming phenotype under these culture conditions. However, when the urothelial cells were implanted subcutaneously into athymic mice on biodegradable synthetic polymers, they formed multilayered structures, suggesting that they retain the capability to differentiate in a living host. The urothelial cells proliferated in an epidermal growth factor independent manner and expressed high levels of transforming growth factor-alpha and amphiregulin messanger ribonucleic acids, suggesting the possibility of autocrine regulation of growth by epidermal growth factor-like factors. Cytogenetic analysis indicated that urothelial cells cultured for 6 passages possessed a normal chromosomal complement. These results demonstrate that primary cultures of autologous human bladder epithelial cells can be extensively expanded in vitro and, consequently, might be used in cell transplantation strategies for genitourinary reconstruction.
Escherichia coli strains with multiple DNA repair defects are hyperinduced for the SOS response (1990)

Escherichia coli strains defective for the repair of apurinic/apyrimidinic sites and for the UvrABC excision repair pathway could be constructed if they also carried a mutation in ung, which encodes uracil glycosylase, or sulA, which encodes an SOS-inducible inhibitor of septation. The resultant strains were sensitive to alkylation damage and hyperinduced for the SOS response, but had unpredictable spontaneous mutation rates.
Mechanochemical preparation and properties of a cellulose–polyethylene composite (2001)

Ball milling of crystalline cellulose with maleated polyethylene (MPE) yields a novel composite with ester bonds formed by reaction of the hydroxy groups of the cellulose with the maleic anhydride groups of MPE; the composite exhibits much improved toughness and ductility compared with the product formed by melt-mixing, probably because of the formation of an interphase of MPE chains bonded on cellulose particles.
Enzymic Profiling of Immobilized Cells Using CZE (1994)

Baker's yeast cells (Saccharomyces cerevisiae) were immobilized on a CZE capillary using a midcapillary frit of novel design. The frit was constructed using a single 50-microns particle with "through pores". Cells trapped on the capillary were profiled using different amino acid beta-naphthylamide-aminopeptidase substrates. These substrates were introduced sequentially and metabolized for 1 min. After incubation the hydrolysis products were withdrawn by electrophoresis and detected by laser-induced fluorescence. An aminopeptidase profile was produced using just 500 cells. The new CZE-based method was found to have several significant advantages over the older cuvette/fluorometer method.