gebhart/patrepeval huggingface dataset:
Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries. (2012)

Musculoskeletal injuries are the most common cause of severe long-term pain and physical disability, and affect hundreds of millions of people around the world. One of the most popular methods used to biologically enhance healing in the fields of orthopaedic surgery and sports medicine includes the use of autologous blood products, namely, platelet rich plasma (PRP). PRP is an autologous concentration of human platelets to supra-physiologic levels. At baseline levels, platelets function as a natural reservoir for growth factors including platelet-derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and insulin-like growth factor (IGF-I). PRP is commonly used in orthopaedic practice to augment healing in sports-related injuries of skeletal muscle, tendons, and ligaments. Despite its pervasive use, the clinical efficacy of PrP therapy and varying mechanisms of action have yet to be established. Basic science research has revealed that PRP exerts is effects through many downstream events secondary to release of growth factors and other bioactive factors from its alpha granules. These effects may vary depending on the location of injury and the concentration of important growth factors involved in various soft tissue healing responses. This review focuses on the effects of PrP and its associated bioactive factors as elucidated in basic science research. Current findings in PRP basic science research, which have shed light on its proposed mechanisms of action, have opened doors for future areas of PrP research.
Efficient scene understanding for intelligent vehicles using a part-based road representation (2013)

In this paper we propose a novel part-based approach to scene understanding, that allows us to infer the properties of traffic scenes, such as location and geometry of lanes and roads. Lanes and roads are parts of our undirected graphical model in which nodes represent parts or sub-parts of scenes and edges represent spatial constraints. Spatial constraints are statistically formulated and allow us to take advantage of low-level relations as well as high-level contextual information. The estimation of scene properties is formulated as an inference problem, which is solved using non-parametric belief propagation. Inferring about high-level scene properties, while relying on error-prone sensory cues is challenging and computational expensive. Therefore, we introduced a novel depth-first message passing scheme. This scheme is applied to several challenging real world scenarios showing robust results and real-time performance.
Transfection Techniques for Neuronal Cells: Table 1. (2010)

<h3>Abstract</h3> Macrophages populate every organ during homeostasis and disease, displaying features of tissue imprinting and heterogeneous activation. The disjointed picture of macrophage biology that emerged from these observations are a barrier for integration across models or with <i>in vitro</i> macrophage activation paradigms. We set out to contextualize macrophage heterogeneity across mouse tissues and inflammatory conditions, specifically aiming to define a common framework of macrophage activation. We built a predictive model with which we mapped the activation of macrophages across 12 tissues and 25 biological conditions, finding a striking commonality and finite number of transcriptional profiles, which we modelled as defined stages along four conserved activation paths. We verified this model with adoptive cell transfer experiments and identified transient RELMɑ expression as a feature of macrophage tissue engraftment. We propose that this integrative approach of macrophage classification allows the establishment of a common predictive framework of macrophage activation in inflammation and homeostasis. <h3>One Sentence Summary</h3> We propose an integrative approach of macrophage classification that allows the establishment of a common framework of macrophage activation in inflammation and homeostasis.
Symptom and Structure Modifying Properties of Chondroitin Sulfate in Osteoarthritis (2007)

Chondroitin sulfate (CS) is a complex carbohydrate polymer with variable sulfation which impacts function. CS exhibits a wide range of biological activities. Many experimental and clinical data are available, affirming that CS represents an effective and safe symptomatic treatment of osteoarthritis (OA) with delayed and sustained effects.
The First Molecularly Characterized Isotactic Polypropylene-block-polyethylene Obtained via “Quasi-Living” Insertion Polymerization (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTThe First Molecularly Characterized Isotactic Polypropylene-block-polyethylene Obtained via "Quasi-Living" Insertion PolymerizationVincenzo Busico, Roberta Cipullo, Nic Friederichs, Sara Ronca, and Maria TogrouView Author Information Dipartimento di Chimica, Università di Napoli "Federico II", Via Cintia, 80126 Naples, Italy, and SABIC EuroPetrochemicals, Research & Development Centre, P.O. Box 319, 6160 AH Geleen, The Netherlands Cite this: Macromolecules 2003, 36, 11, 3806–3808Publication Date (Web):May 3, 2003Publication History Received26 February 2003Revised2 April 2003Published online3 May 2003Published inissue 1 June 2003https://doi.org/10.1021/ma0342527Copyright © 2003 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1099Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (54 KB) Get e-AlertsSUBJECTS:Alkyls,Catalysts,Monomers,Polymerization,Thermoresponsive polymers Get e-Alerts
Nucleation and growth of thin films (1984)

A review is given of the nucleation and growth processes occurring in thin film formation. Emphasis is given to quantitative nucleation theories and to the role of electron microscopy and surface techniques in providing data to test such theories. The relations between the thermodynamics of adsorption and the kinetics of crystal growth is stressed. Experimental examples are taken from the island growth, layer plus island (or Stranski-Krastanov) and layer growth modes. The shapes of growing crystallites are briefly discussed.
Eulerian video magnification for revealing subtle changes in the world (2012)

Our goal is to reveal temporal variations in videos that are difficult or impossible to see with the naked eye and display them in an indicative manner. Our method, which we call Eulerian Video Magnification, takes a standard video sequence as input, and applies spatial decomposition, followed by temporal filtering to the frames. The resulting signal is then amplified to reveal hidden information. Using our method, we are able to visualize the flow of blood as it fills the face and also to amplify and reveal small motions. Our technique can run in real time to show phenomena occurring at the temporal frequencies selected by the user.
Human Metastatic Prostate PC3 Cell Lines Degrade Bone Using Matrix Metalloproteinases (1998)

Bone metastases are often associated with osteolysis and subsequent pathological fractures. To determine if metastatic human cancer cells can directly degrade non-mineralized and mineralized bone, we used prostate PC3 adenocarcinoma cell lines, which were originally established from skeletal metastases. We show that PC3 cells and their conditioned medium degraded non-mineralized, osteoid-like radiolabelled extracellular matrices from human Saos2 and U2OS osteoblast-like cells. These cells also directly degraded mineralized bone by inducing (45)Ca release from rat fetal calvariae and forming resorption pits on bone slices, an effect increased by transforming growth factor-beta(1). A role for matrix metalloproteinases in degradation was shown by: (1) stimulation by the phorbol ester TPA of PC3-induced matrix degradation and release of matrix metalloproteinase activity; (2) abrogation of matrix degradation by 1,10-phenanthroline, a metalloproteinase inhibitor, and (3) degradation of purified type I collagen by PC3 cells and their conditioned medium. We demonstrate that human prostate cancer cells can directly degrade bone-related matrices and that matrix metalloproteinases have a role in this process.
Access Ordering and Effective Memory Bandwidth (1993)

Contents 1 Introduction..............................................................................................................1 1.1 General System Model.........................................................................................................3 1.2 Access Ordering Observation ..............................................................................................4 1.3 Computation Domain...........................................................................................................6 1.4 Memory System Domain .....................................................................................................8 1.4.1 Memory Architectures...........................................................................................8 1.4.2 Memory Device Types ..........................................................................................9 1.5 Performance Modeling ....................................................................
Designing LDPC codes using bit-filling (2002)

Bipartite graphs of bit nodes and parity check nodes arise as Tanner graphs corresponding to low density parity check codes. Given graph parameters such as the number of check nodes, the maximum check-degree, the bit-degree, and the girth, we consider the problem of constructing bipartite graphs with the largest number of bit nodes, that is, the highest rate. We propose a simple-to-implement heuristic bit-filling algorithm for this problem. As a benchmark, our algorithm yields codes better or comparable to those in MacKay (1999).
Detection and Analysis of Chimeric Tertiary Structures by Backbone Thioester Exchange: Packing of an α Helix against an α/β‐Peptide Helix (2009)

Über den Austausch von Rückgratthioestern wurde ein Basistyp des Protein-Foldamer-Packungsmotivs untersucht, die Assoziation einer α-Helix und einer α/β-Peptidfoldamer-Helix. Er ist analog zu einer antiparallelen Doppelwendel-Tertiärstruktur in einem reinen α-Reste-Rückgrat. Die Seitenkettenpackungspräferenzen an dieser chimären Grenzfläche ähneln denen, die die Paarungstendenzen zwischen antiparallelen α-Helices bestimmen. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Diphtheria Toxin (1977)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Fumaric Acid Esters Suppress Peripheral CD4- and CD8-Positive Lymphocytes in Psoriasis (1998)

Our investigations of systemic effects of fumaric acid esters demonstrate the suppressive character of this medication. Effects of cell count reduction in leukocyte and lymphocyte numbers over the entire period of 12 months could be observed. The lymphocytic cell count number is obviously linked to the clinical effect.
Test for enterotoxigenic Escherichia coli using Y-1 adrenal cells in miniculture (1975)

A rapid, potentially clinically useful test for detection of enterotoxigenic Escherichia coli is described. Whole bacterial cultures of enterotoxigenic E. coli, when briefly exposed to Y1 adrenal cells in tissue miniculture, effect a rounding response in the tissue culture that can be discerned at 18 to 24 h. The tissue culture technique agreed with the rabbit ileal loop in all 58 enterotoxigenic and 52 non-enterotoxigenic E. coli strains tested.
Towards the discovery of molecules involved in hematophagous blood feeding (2000)

Dentate granule cells are generally considered to be relatively resistant to excitotoxicity and have been associated to robust synaptogenesis after neuronal damage. Synaptic reorganization of dentate granule cell axons, the mossy fibers, has been suggested to be relevant for hyperexcitability in human temporal lobe epilepsy and animal models. A recent hypothesis has suggested that mossy fiber sprouting is dependent on newly formed dentate granule cells. However, we have recently demonstrated that cycloheximide (CHX) can block the mossy fiber sprouting that would be otherwise induced by different epileptogenic agents and do not interfere with epileptogenesis in those models. Here, we investigated cell damage and neurogenesis in the dentate gyrus of pilocarpine-or kainate-treated animals with or without the co-administration of CHX. Dentate granule cells were highly vulnerable to pilocarpine induced-status epilepticus (SE), but hardly damaged by kainate induced-SE. CHX-pretreatment markedly reduced the number of injured neurons after pilocarpine-induced SE. Induction of SE dramatically increased the mitotic rate of KA and KA + CHX treated animals. Induction of SE in animals in-jected with pilocarpine alone led to increases of between two to sevenfold in the mitotic rate of dentate granule cells as compared to increases of between five and thirtyfold for pilocarpine+CHX animals. These observations indicate that in presence of cycloheximide the increase of the mitotic rate after pilocarpine-induced SE may be due to protection of a vulnerable precursor cell population that would otherwise degenerate. We further suggest that the mossy fiber sprouting and neurogenesis of granule cells are not necessarily related events. - ( September 14, 1999 ) .
Ultrahigh-Q Nanocavity with 1D Photonic Gap (2008)

Recently, various wavelength-sized cavities with theoretical Q values of approximately 10(8) have been reported, however, they all employ 2D or 3D photonic band gaps to realize strong light confinement. Here we numerically demonstrate that ultrahigh-Q (2.0x10(8)) and wavelength-sized (V(eff) approximately 1.4(lambda/n)3) cavities can be achieved by employing only 1D periodicity.
Identification of a nuclear domain with deacetylase activity (2000)

Here, we describe the identification and characterization of a nuclear body (matrix-associated deacetylase body) whose formation and integrity depend on deacetylase activity. Typically, there are 20-40 0.5-microM bodies per nucleus, although the size and number can vary substantially. The structure appears to contain both class I and the recently described class II histone deacetylases (HDAC)5 and 7 along with the nuclear receptor corepressors SMRT (silencing mediator for retinoid and thyroid receptor) and N-CoR (nuclear receptor corepressor). Addition of the deacetylase inhibitors trichostatin A and sodium butyrate completely disrupt these nuclear bodies, providing a demonstration that the integrity of a nuclear body is enzyme dependent. We demonstrate that HDAC5 and 7 can associate with at least 12 distinct proteins, including several members of the NuRD and Sin3A repression complexes, and appear to define a new but related complex.
Pharmacokinetics and Pharmacodynamics of a Bolus and Infusion of Cangrelor: A Direct, Parenteral P2Y12 Receptor Antagonist (2009)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cangrelor administered as an intravenous bolus plus a continuous infusion in healthy volunteers. Twenty-two healthy volunteers are randomized to receive 1 of 2 intravenous cangrelor dosing regimens: a 15-microg/kg bolus followed by a 2-microg/kg/min infusion or a 30-microg/kg bolus followed by a 4-microg/kg/min infusion. The infusion is continued for 60 minutes, and serial blood samples are obtained for evaluation of pharmacokinetic and pharmacodynamic parameters. Administration of an intravenous bolus followed by a continuous infusion rapidly achieves maximum concentrations of cangrelor that are associated with extensive platelet inhibition within 2 minutes. Moreover, extensive platelet inhibition is maintained throughout the infusion period with near-full recovery of platelet function within 60 to 90 minutes of terminating the infusion. The effect of high-dose cangrelor is more consistent and demonstrates a greater level of inhibition on adenosine diphosphate-induced P-selectin expression; how ever, no significant differences are observed between the 2 dosing regimens with regard to platelet aggregation or time to recovery of platelet function. Cangrelor administered as an intravenous bolus followed by a continuous infusion in healthy volunteers offers rapid and reversible inhibition of platelet function.
Fertility of young Cashmere goats after laparoscopic insemination (1991)

SUMMARY Maiden 18-month-old Cashmere does (JV=254) were inseminated laparoscopically with frozenthawed semen after treatment with Controlled Internal Drug Release devices and pregnant mare's serum gonadotrophin (PMSG) in the breeding season of 1989 in Tasmania. Kidding rates(does kidded/inseminated) were not statistically different after the insemination of 1, 5 or 25 × 10 6 motile spermatozoa (50·0, 55·8 and 56·4%), andfor semen frozen by the pellet or straw methods (56·8 and 50·8%). The fertility results suggest that the critical threshold may not have been reached at 1 × 10 6 frozen-thawed motile spermatozoa.
Compiler-based adaptive fetch throttling for energy-efficiency (2006)

Front-end instruction delivery accounts for a significant fraction of energy consumption in dynamically scheduled superscalar processors. Different front-end throttling techniques have been introduced to reduce the chip-wide energy consumption caused by redundant fetching. Hardware-based techniques, such as flow-based throttling, could reduce the energy consumption considerably, but with a high performance loss. On the other hand, compiler-based IPC-estimation-driven software fetch throttling (CFT) techniques result in relatively low performance degradation, which is desirable for high-performance processors. However, their energy savings are limited by the fact that they typically use a predefined fixed low IPC-threshold to control throttling. In this paper, we propose a compiler-based adaptive fetch throttling (CAFT) technique that allows changing the throttling threshold dynamically at runtime. Instead of using a fixed threshold, our technique uses the decode/issue difference (DID) to assist the fetch throttling decision based on the statically estimated IPC. Changing the threshold dynamically makes it possible to throttle at a higher estimated IPC, thus increasing the throttling opportunities and resulting in larger energy savings. We demonstrate that CAFT could increase the energy savings significantly compared to CFT, while preserving its benefit of low performance loss. Our simulation results show that the proposed technique doubles the energy-delay product (EDP) savings compared to the fixed threshold throttling and achieves a 6.1% average EDP saving.
Document analysis for visualization (1995)

Article Document analysis for visualization Share on Author: David Dubin Dept. Information Science, University of Pittsburgh, Pittsburgh, PA Dept. Information Science, University of Pittsburgh, Pittsburgh, PAView Profile Authors Info & Claims SIGIR '95: Proceedings of the 18th annual international ACM SIGIR conference on Research and development in information retrievalJuly 1995 Pages 199–204https://doi.org/10.1145/215206.215360Online:01 July 1995Publication History 9citation602DownloadsMetricsTotal Citations9Total Downloads602Last 12 Months9Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Dietary phytosterol inhibits the growth and metastasis of MDA-MB-231 human breast cancer cells grown in SCID mice. (2000)

The objective of the present study was to investigate the effect of dietary phytosterols on the growth and metastasis of the human breast cancer MDA-MB-231 cell line xenografted in SCID mice. Two groups of animals were fed AIN-93G diet supplemented with 0.2% cholic acid and 2% sterol (cholesterol or phytosterol mixture) for 15 days before inoculation of the tumor into the right inguinal mammary fat pad. Tumor growth and food consumption were recorded weekly throughout the 8 weeks of the experiment. At the end of the experiment, the animals fed phytosterol had a 40% lower serum cholesterol and 20 and 30 fold higher serum beta-sitosterol and campesterol, respectively as compared to those fed cholesterol. There was no difference between the two groups in body weight and food consumption. However, the tumor size in animals fed phytosterols was 33% smaller (P < 0.03) and had 20% fewer metastases to lymph nodes and lungs than the cholesterol group. At termination, the tumor weight of the animals fed the phytosterol diet was also less (P < 0.07) than that of the cholesterol group. It is concluded that dietary phytosterols retard the growth and spread of breast cancer cells.