Triglycerides and Coronary Heart Disease Revisited (Again) (2007)

Editorials18 September 2007Triglycerides and Coronary Heart Disease Revisited (Again)Michael H. Criqui, MD, MPHMichael H. Criqui, MD, MPHFrom University of California, San Diego, La Jolla, CA 92093-0607.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-6-200709180-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Despite the extensive literature on the relationship of lipid and lipoprotein particles to coronary heart disease (CHD) incidence, the specific association of triglycerides with incident CHD has arguably generated more disagreement than any other measure. The most parsimonious explanations for this controversy are that contradictory results abound and that positive studies typically show a modest effect size. Two published meta-analyses concurred that triglycerides were independent risk factors for CHD, even after adjustment for high-density lipoprotein (HDL) cholesterol, which is strongly and inversely correlated with triglycerides (1, 2). In the first meta-analysis, published in 1996 (1), the overall relative risk for ...References1. Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 1996;3:213-9. [PMID: 8836866] CrossrefMedlineGoogle Scholar2. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115:450-8. [PMID: 17190864] CrossrefMedlineGoogle Scholar3. Criqui MH, Heiss G, Cohn R, Cowan LD, Suchindran CM, Bangdiwala S, et al. 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Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 2004;110:3512-7. [PMID: 15537681] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Michael H. Criqui, MD, MPHAffiliations: From University of California, San Diego, La Jolla, CA 92093-0607.Disclosures: None disclosed.Corresponding Author: Michael H. Criqui, MD, MPH, University of California, San Diego, 9500 Gilman Drive, MC 0607, La Jolla, CA 92093-0607. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChanges in Triglyceride Levels and Risk for Coronary Heart Disease in Young Men Amir Tirosh , Assaf Rudich , Tzippora Shochat , Dorit Tekes-Manova , Eran Israeli , Yaakov Henkin , Ilan Kochba , and Iris Shai Metrics Cited bySubstituting Water for Sugar-Sweetened Beverages Reduces Circulating Triglycerides and the Prevalence of Metabolic Syndrome in Obese but Not in Overweight Mexican Women in a Randomized Controlled TrialLifestyle Change and High-Density Lipoprotein Change: The US Department of Veterans Affairs Normative Aging StudyHigh-Density Lipoprotein and Mortality Before Age 90 in Male PhysiciansRelation Between High-Density Lipoprotein Cholesterol and Survival to Age 85 Years in Men (from the VA Normative Aging Study)Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery DiseaseChylomicronemia Elicits Atherosclerosis in Mice—Brief ReportIntercellular adhesion molecule-1 gene K469E polymorphism and ischemic stroke: a case-control study in a Chinese populationBenefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysisDrug therapy for hypertriglyceridemia: Fibrates and omega-3 fatty acidsAbdominal obesity, hypertriglyceridemia, hypertriglyceridemic waist phenotype and risk of type 2 diabetes in American adultsDietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome 18 September 2007Volume 147, Issue 6Page: 425-427KeywordsCholesterolHypercholesterolemiaLipoproteinsMedical risk factorsMetabolic syndrome ePublished: 18 September 2007 Issue Published: 18 September 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. 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