gebhart/patrepeval huggingface dataset:
Total Synthesis of (+-)-17β-Hydroxy-Δ9(10)-des-A-androsten-5-one [(+-)-2,3,3a,4,5,7,8,9,9β,9bα-Decahydro-3β-hydroxy-3aβ,6-dimethyl-1H-benz[e]inden-7-one] (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal Synthesis of (+-)-17β-Hydroxy-Δ9(10)-des-A-androsten-5-one [(+-)-2,3,3a,4,5,7,8,9,9β,9bα-Decahydro-3β-hydroxy-3aβ,6-dimethyl-1H-benz[e]inden-7-one]Zoltan Hajos, Robert Mitcheli, David Parrish, and Eugene OlivetoCite this: J. Org. Chem. 1967, 32, 10, 3008–3010Publication Date (Print):October 1, 1967Publication History Published online31 July 2003Published inissue 1 October 1967https://pubs.acs.org/doi/10.1021/jo01285a600https://doi.org/10.1021/jo01285a600research-articleACS PublicationsRequest reuse permissionsArticle Views657Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
768. Studies with acetylenes. Part II. Some reactions of Grignard reagents with propargylic halides. Model linoleic and linolenic acid systems (1957)

S. S. Nigam and B. C. L. Weedon, J. Chem. Soc., 1957, 3868 DOI: 10.1039/JR9570003868
E2F Family Members Are Differentially Regulated by Reversible Acetylation (2000)

The six members of the E2F family of transcription factors play a key role in the control of cell cycle progression by regulating the expression of genes involved in DNA replication and cell proliferation. E2F-1, -2, and -3 belong to a structural and functional subfamily distinct from those of the other E2F family members. Here we report that E2F-1, -2, and -3, but not E2F-4, -5, and -6, associate with and are acetylated by p300 and cAMP-response element-binding protein acetyltransferases. Acetylation occurs at three conserved lysine residues located at the N-terminal boundary of their DNA binding domains. Acetylation of E2F-1 in vitro and in vivo markedly increases its binding affinity for a consensus E2F DNA-binding site, which is paralleled by enhanced transactivation of an E2F-responsive promoter. Acetylation of E2F-1 can be reversed by histone deacetylase-1, indicating that reversible acetylation is a mechanism for regulation also of non-histone proteins.
Safety, Pharmacokinetics, and Efficacy of AMG 706, an Oral Multikinase Inhibitor, in Patients With Advanced Solid Tumors (2007)

In this study of patients with advanced refractory solid tumors, AMG 706 was well tolerated and displayed favorable pharmacokinetics and evidence of antitumor activity. Additional studies of AMG 706 as monotherapy and in combination with various agents are ongoing.
A model for estimating trace-sample miss ratios (1991)

Unknown references, also known as cold-start misses, arise during trace-driven simulation of uniprocessor caches because of the unknown initial conditions. Accurately estimating the miss ratio of unknown references, denoted by &amp;mu;, is particularly important when simulating large caches with short trace samples, since many references may be unknown.In this paper we make three contributions regarding &amp;mu;. First, we provide empirical evidence that &amp;mu; is much larger than the overall miss ratio (e.g., 0.40 vs. 0.02). Prior work suggests that they should be the same. Second, we develop a model that explains our empirical results for long trace samples. In our model, each block frame is either live , if its next reference will hit, or dead, if its next reference will miss. We model each block frame as an alternating renewal process, and use the renewal-reward theorem to show that &amp;mu; is simply the fraction of time block frames are dead. Finally, we extend the model to handle short trace samples and use it to develop several estimators of &amp;mu;. Trace-driven simulation results show these estimators lead to better estimates of overall miss ratios than do previous methods.
Controlling Automobile Insurance Costs (1992)

We begin by providing an overview of the auto insurance system and the structure of the auto insurance market. We then turn to an analysis of the factors underlying the auto insurance price increases experienced in recent years. We find that the auto insurance inflation of the 1980s was caused primarily by increases in cost factors, especially inflation in the severity of personal injury claims. There is no persuasive evidence that increasing profit rates or expense loadings contributed to inflation in premiums. The paper concludes with recommendations for bringing costs under control.
Sphingosine-1-Phosphate/Sphingosine Kinase Pathway Is Involved in Mouse Airway Hyperresponsiveness (2007)

Sphingosine-1-phosphate (S1P) has been shown to regulate numerous and diverse cell functions, including smooth muscle contraction. Here we assessed the role of S1P/Sphingosine kinase (SPK) pathway in the regulation of bronchial tone. Our objective was to determine, using an integrated pharmacologic and molecular approach, (1) the role of S1P as endogenous modulator of the bronchial tone, and (2) the linkage between S1P pathway and bronchial hyperresponsiveness. We evaluated S1P effects on isolated bronchi and whole lungs, harvested from Balb/c mice sensitized to ovalbumin (OVA) versus vehicle-treated mice, by measuring bronchial reactivity and lung resistance. We found that S1P administration on nonsensitized mouse bronchi does not cause any direct effect on bronchial tone, while a significant increase in Ach-induced contraction occurs after S1P challenge. Conversely, in OVA-sensitized mice S1P/SPK pathway triggers airway hyperesponsiveness. Indeed, S1P causes a dose-dependent contraction of isolated bronchi. Similarly, in the whole lung system S1P increased airway resistance only in OVA-sensitized mice. The action on bronchi of S1P is coupled to an enhanced expression of SPK(1) and SPK(2) as well as of S1P(2) and S1P(3) receptors. In these experiments the key role for S1P/SPK in hyperreactivity has been confirmed by pharmacologic modulation of SPKs. S1P/SPK pathway does not seem to play a major role in physiologic conditions, while it may become critical in pathologic conditions. These results open new windows for therapeutic strategies in diseases like asthma.
Werner syndrome protein limits MYC-induced cellular senescence (2003)

The MYC oncoprotein is a transcription factor that coordinates cell growth and division. MYC overexpression exacerbates genomic instability and sensitizes cells to apoptotic stimuli. Here we demonstrate that MYC directly stimulates transcription of the human Werner syndrome gene, WRN, which encodes a conserved RecQ helicase. Loss-of-function mutations in WRN lead to genomic instability, an elevated cancer risk, and premature cellular senescence. The overexpression of MYC in WRN syndrome fibroblasts or after WRN depletion from control fibroblasts led to rapid cellular senescence that could not be suppressed by hTERT expression. We propose that WRN up-regulation by MYC may promote MYC-driven tumorigenesis by preventing cellular senescence.
Heating characteristics of a helical microwave applicator for transurethral hyperthermia of benign prostatic hyperplasia (1991)

A new applicator for intraurethral hyperthermic treatment of benign prostatic hyperplasia is described. The applicator uses an insulated helical antenna wound on the outer surface of a silicone urological (Foley) balloon catheter. The balloon catheter assures rapid and reproducible localization of the antenna in the prostatic urethra. Two small cannulae are fixed to the exterior surface of the applicator. One holds a temperature control sensor at a fixed location, the other is used to map temperature along the applicator. Two-dimensional SAR and steady-state temperature distributions measured in a plane tangent to the applicator in a tissue-equivalent phantom are presented, as well as longitudinal temperature distributions measured in situ at the applicator-urethral interface. Prostatic temperatures were also measured intraoperatively. The applicator appears to be capable of elevating temperature to greater than 42 degrees C in a cylindrically symmetric volume of about 4 cm length and about 0.5 cm radial penetration surrounding the antenna. The heating characteristics of this applicator are similar to an earlier design that employed an array of three dipoles. The helical applicator is narrower, more flexible and simpler to use than the earlier design.
Proceedings of the Workshop on Genetic Programming: From Theory to Real-World Applications (1995)

Proceedings of a workshop held in conjunction with the 12th International International Conference on Machine Learning in July 1995 in Tahoe City, CA.
The role of user studies in the design of OpenDoc (1997)

Article Free Access Share on The role of user studies in the design of OpenDoc Authors: Elizabeth Dykstra-Erickson Apple Computer, Inc., Human Interface Design Center, 1 Infinite Loop, Cupertino, CA Apple Computer, Inc., Human Interface Design Center, 1 Infinite Loop, Cupertino, CAView Profile , Dave Curbow Apple Computer, Inc., Human Interface Design Center, 1 Infinite Loop, Cupertino, CA Apple Computer, Inc., Human Interface Design Center, 1 Infinite Loop, Cupertino, CAView Profile Authors Info & Claims DIS '97: Proceedings of the 2nd conference on Designing interactive systems: processes, practices, methods, and techniquesAugust 1997 Pages 111–120https://doi.org/10.1145/263552.263588Published:01 August 1997Publication History 2citation312DownloadsMetricsTotal Citations2Total Downloads312Last 12 Months12Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
High-Yielding Method for On-Column Derivatization of Protected Oligodeoxy- nucleotides and Its Application to the Convergent Synthesis of 5‘,3‘-Bis-conjugates (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHigh-Yielding Method for On-Column Derivatization of Protected Oligodeoxy- nucleotides and Its Application to the Convergent Synthesis of 5',3'-Bis-conjugatesJeffrey D. Kahl, Dustin L. McMinn, and Marc M. GreenbergView Author Information Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523 Cite this: J. Org. Chem. 1998, 63, 15, 4870–4871Publication Date (Web):July 8, 1998Publication History Received2 April 1998Published online8 July 1998Published inissue 1 July 1998https://pubs.acs.org/doi/10.1021/jo980594chttps://doi.org/10.1021/jo980594crapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views184Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biopolymers,Conjugate acid-base pairs,Molecular properties,Nutrition,Reagents Get e-Alerts
Microstructured Silicone Substrate for Printable and Stretchable Metallic Films (2011)

Stretchable electronics (i.e., hybrid inorganic or organic circuits integrated on elastomeric substrates) rely on elastic wiring. We present a technique for fabricating reversibly stretchable metallic films by printing silver-based ink onto microstructured silicone substrates. The wetting and pinning of the ink on the elastomer surface is adjusted and optimized by varying the geometry of micropillar arrays patterned on the silicone substrate. The resulting films exhibit high electrical conductivity (∼11 000 S/cm) and can stretch reversibly to 20% strain over 1000 times without failing electrically. The stretchability of the ≥200 nm thick metallic film relies on engineered strain relief in the printed film on patterned PDMS.
INTERSTITIAL PNEUMONITIS FOLLOWING AUTOLOGOUS BONE MARROW TRANSPLANTATION (1988)

Interstitial pneumonitis (IP) occurred in 20 of 143 (14%) patients who received cytoreductive therapy followed by autologous bone marrow transplantation (BMT) as treatment for malignancy. IP occurred at a median onset time of 41 days (5 to 624 days). All but three of the episodes were fatal. Of the thirteen cases in which tissue was examined, half were idiopathic; the remainder were due to various infectious agents. The actuarial incidences of idiopathic (7%) and CMV IP (2%) in these marrow autograft recipients were lower than the incidences of idiopathic (19%) and CMV IP (17%) in comparably treated recipients of allogeneic BMT (P less than or equal to 0.001 for both comparisons).
Dispersions of Functionalized Single-Walled Carbon Nanotubes in Strong Acids:Solubility and Rheology (2007)

The manipulation and processing of single-wall carbon nanotubes (SWNTs) is limited by their poor solubility in most common solvents. Covalent sidewall functionalization of SWNTs provides an excellent route to improve their solubility. Here we have studied the relationship between sidewall functionalization and phase behavior of solutions of functionalized SWNTs (f-SWNTs) in strong acids. We use centrifugation in conjunction with UV-Vis-nlR spectroscopy to quantify the solubility of f-SWNTs in strong acids. We image the dispersions of functionalized tubes by polarized light microscopy. We find that adding butyl groups increases marginally the solubility of SWNTs in 102% sulfuric acid in the isotropic phase; adding 9-nonadecyne groups roughly doubles the solubility of SWNTs. Viscosity measurements in dilute solutions are sensitive to de-bundling. We compare the viscosity-concentration dependence of dilute pristine and f-SWNTs to assess whether and how functionalization promotes de-bundling and stabilizes the tubes. The phase behavior and rheology of these f-SWNTs parallels with that of pristine SWNTs; 9-nonadecylated SWNTs have higher solubility and should be easier to process.
Vaccines against Human Immunodeficiency Virus -- Progress and Prospects (1993)

The frightening pace of the worldwide spread of the human immunodeficiency virus (HIV) demands that priority be placed on the development of an effective vaccine1. Two distinct populations of viruses responsible for the acquired immunodeficiency syndrome (AIDS) have been defined: HIV type 2 (HIV-2), the viral group responsible for AIDS in West Africa, and HIV type 1 (HIV-1), the viral group that accounts for the AIDS epidemic in Central Africa and the rest of the world2. The genomes of both HIV groups encode for three structural proteins: an envelope glycoprotein that constitutes the viral outer coat, a core . . .
Towards continuous monitoring of mental workload (2012)

Continuous monitoring of mental workload offers new opportunities to support preventing mental disorders and maintaining mental health. In order to achieve a quantification of mental workload, different load levels have to be discriminated. This work goes towards continuous monitoring of mental workload in daily life: we present our experimental designs and the achieved results in discriminating three levels of mental workload in a laboratory simulation and in daily life. In the lab setting we achieved an average recognition rate of 82.14% for all 7 subjects under study. In daily life two subjects were monitored during low, medium and high workload days. We achieved average accuracy rates of 72.03% and 77.66% for both subjects respectively. Finally we have investigated whether the data from the lab experiment are suitable to discriminate low, medium and high workload days.
Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma (1998)

Although most patients with brain metastases resulting from melanoma have a dismal prognosis, some who are likely to survive for longer periods can be identified. In these patients surgical resection can significantly prolong meaningful survival. The decision to recommend surgery should be based primarily on the resectability of the brain metastases and on the status and number of other organs with metastatic lesions.
Metabolic Syndrome: A Clinical and Molecular Perspective (2004)

The metabolic syndrome is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension, and dyslipidemia (hypertriglyceridemia and low HDL cholesterol levels). According to recently defined criteria, the metabolic syndrome is prevalent and is associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Primary defects in energy balance that produce obesity (and visceral adiposity in particular) are sufficient to drive all aspects of the syndrome. Increased free fatty acids and lipid accumulation in certain organs are mediators of insulin resistance. Obesity also leads to a proinflammatory and prothrombotic state that potentiates atherosclerosis. Pathways leading directly from adiposity to the genesis of dyslipidemia and hypertension have been elucidated. Recent knowledge implies a role for fat-derived "adipokines," including TNF alpha and adiponectin, as pathogenic contributors or protective factors. Current therapies include diet and exercise as well as agents indicated for the treatment of individual components of the syndrome. Future therapies may accrue from the aggressive pursuit of newer molecular drug targets that have the potential to prevent or treat multiple aspects of the metabolic syndrome.
Novel 3,7-Diheterabicyclo[3.3.1]nonanes That Possess Predominant Class III Antiarrhythmic Activity in 1-4 Day Post Infarction Dog Models:  X-ray Diffraction Analysis of 3-[4-(1H-Imidazol-1-yl)benzoyl]-7-isopropyl-3,7-diazabicyclo[3.3.1]nonane Dihydroperchlorate (1996)

Several 3,7-diheterabicyclo[3.3.1]nonanes (DHBCNs) were prepared and screened in the Harris dog model for their ability to abolish pace-induced and sustained ventricular tachycardia (SVT) or prevent induction of ventricular tachycardia. In addition, an electrophysiological examination was made in the infarcted hearts of each animal to determine if more than one class activity was present. The examples exhibited predominately class III antiarrhythmic activity via a prolongation of the ventricular effective refractory period (VERP) in the models, although there may well be an underlying class Ib action present as exemplified by the ability of several of the agents to slow conduction in the myocardial infarcted dog hearts. 3-[4-(1H-Imidazol-1-yl)benzoyl]-7-isopropyl-3,7-diazabicyclo[3.3.1]nonan e dihydroperchlorate displayed powerful class III activity in the model systems while several other DHBCNs exhibited various degrees of class III action. An X-ray diffraction analysis revealed that this compound has a 3,7-diazabicyclo[3.3.1]nonane bicyclic unit in a chair-chair conformation.
Selection of Reaction Additives Used in the Preparation of Monomeric Antibody−Calicheamicin Conjugates (2007)

The formation of protein aggregates can be a major problem during the preparation of antibody-drug conjugates. Herein is described the methods by which reaction additives were selected, which reduce the tendency of antibodies to aggregate during the attachment of the cytotoxic agent calicheamicin to form an immunoconjugate. Reaction conditions were delineated that produced optimized yields of monomeric conjugates. These conditions were used in the preclinical preparations of gemtuzumab ozogamicin (Mylotarg), the first commercially available chemotherapeutic immunoconjugate.
Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity (2013)

10.1021/ma4019685
Radiative cooling to low temperatures: General considerations and application to selectively emitting SiO films (1981)

Radiative cooling occurs because the atmospheric emittance is low in the wavelength interval 8–13 μm particularly if the air is dry. We derive expressions which specify the optical properties demanded for a surface capable of being cooled to low temperatures. The key factor is infrared selectivity with low reflectance in the 8–13 μm ’’window’’ but high reflectance elsewhere. Considering only radiation balance, ideal surfaces of this type can yield temperature differences of ∼50 °C while the cooling power at near-ambient temperatures is ∼100 W/m2. However, nonradiative exchange limits the practically achievable temperature difference. SiO films on Al were investigated as an example of an infrared-selective surface. The infrared optical properties of SiO were determined by a novel and accurate technique. These data were used to compute the spectral radiative properties of Al coated with SiO films of different thicknesses. The spectral selectivity was largest for 1.0-μm-thick films. This kind of surface was produced by evaporation of SiO onto smooth Al. The measured reflectance agreed with computations. Practical tests of radiative cooling were performed using a SiO-coated Al plate placed under transparent polyethylene films in a polystyrene box. An identical panel containing a blackbody radiator was used for comparison. The performance of the panels was tested during clear nights. It was in good qualitative agreement with theoretical expectations.
Perineural and intraneural inflammatory infiltrates in the intestines of patients with systemic connective-tissue disease. (1989)

Intestinal biopsy specimens were examined from patients with connective-tissue diseases who had symptoms that were thought to represent early gastrointestinal involvement by the disease. Specimens from the small and large intestines contained eosinophils and mast cells, in close association with Meissner's and Auerbach's plexuses. The intimate association of mast cells and eosinophils in various stages of activation and degranulation with nerves was confirmed by electron microscopy. These cells, particularly the eosinophil with its neurotoxic potential, in close proximity to the intramural nerves may contribute to the recognized motor disorders in patients with scleroderma and similar connective-tissue diseases.
Increased expression of system large amino acid transporter (LAT)-1 mRNA is associated with invasive potential and unfavorable prognosis of human clear cell renal cell carcinoma (2013)

These findings suggest that LAT1 mRNA is related to the invasive and progressive potential of clear cell RCC.