gebhart/patrepeval huggingface dataset:
Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamine (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamineChi Huey Wong, Ruo Wang, and Yoshitaka IchikawaCite this: J. Org. Chem. 1992, 57, 16, 4343–4344Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00042a008https://doi.org/10.1021/jo00042a008research-articleACS PublicationsRequest reuse permissionsArticle Views406Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nicotinic Acetylcholine Receptors in the Human Nervous System (1991)

Nicotinic acetylcholine receptors (AChR) are key molecules that mediate chemical communications between cells in various parts of the body: at the neuromuscular junction, in autonomic ganglia and in several areas of the brain. The activation of AChR by the acetylcholine (ACh) released from nerve terminals induces an influx of cations, mainly Na+ ions, through the cell membrane, consequently depolarizing the target cell.
Estrogen mediates the sex difference in post-burn immunosuppression (2000)

Previous studies in our laboratory have demonstrated that cell-mediated immune function was suppressed in female, but not male, mice at 10 days after burn injury and was mediated, in part, by increased production of interleukin-6 (IL-6). Because 17beta-estradiol (E(2)) influences immune function after trauma and the hormone is known to regulate IL-6 production, the effect of E(2) on immune function after thermal injury was examined. Increased circulating concentrations of E(2) corresponded with suppressed delayed-type hypersensitivity (DTH) and splenocyte-proliferative responses, and increased circulating concentrations of IL-6 in female mice after burn. Ovariectomy restored the suppressed DTH response and decreased IL-6 concentrations, and administration of exogenous E(2) to both ovariectomized females and intact male mice resulted in a suppressed DTH response. In addition, in vitro treatment with E(2) suppressed splenocyte proliferation in a macrophage-dependent manner and enhanced macrophage production of IL-6. These results strongly suggest that the sex difference in cell-mediated immunity 10 days after burn injury is mediated by altered concentrations of E(2), which in turn modulate key macrophage-derived immunoregulatory cytokines.
Oral L-Carnitine: Metabolite Formation and Hemodialysis (2006)

L-Carnitine has important roles in intermediary metabolism and patients with end-stage renal disease who are undergoing hemodialysis may develop a secondary L-carnitine deficiency. The extent of accumulation of the metabolites trimethylamine and trimethylamine-N-oxide when L-carnitine is administered orally has not been investigated previously in this population. Oral L-carnitine at a dose of 1 g daily was administered for twelve days to six patients with end-stage renal disease undergoing hemodialysis thrice weekly. Pre-dialysis plasma concentrations of L-carnitine (mean ± SD) increased significantly (P < 0.05) from day 1 (baseline; 32.4 ± 6.1 μM) to day 8 (66.1 ± 13.8 μM) remaining constant thereafter. Although plasma levels of trimethylamine remained unaltered, the pre-dialysis plasma concentrations of trimethylamine- N-oxide increased significantly (P < 0.05) from day 1 (289.1 ± 236.1 μM) to day 12 (529.0 ± 237.9 μM). The hemodialysis clearances for L-carnitine, trimethylamine and trimethylamine-N-oxide were 14.3 ± 8.2, 14.1 ± 10.6 and 12.4 ± 5.4 L/h, respectively, indicating their efficient removal by dialysis. Oral administration of L-carnitine at a dose of 1 g daily increases plasma concentrations of this substance to physiological levels in patients with end-stage renal disease who are undergoing hemodialysis. However, concerns about the possible deleterious consequences of such a dosage regimen still remain given that plasma concentrations of trimethylamine-N-oxide were continually rising and approximately doubled in a two-week period. Keywords: L-Carnitine, trimethylamine, trimethylamine-N-oxide, end-stage renal disease, hemodialysis
Abstract 4493: Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor, in vitro in urothelial carcinoma of the bladder (2011)

Abstract Mammalian target of rapamycin (mTOR) has been shown to play a key role in energy sensing, cell growth, and cell survival in many cancers. Although alterations of the PI3K/Akt/mTOR pathway are frequent in urothelial carcinoma (UC), the effects of pharmacologic targeting of this pathway have not been systematically evaluated. Selective inhibitors of the mTORC1 component of mTOR have modest activity in renal cell cancer and are currently being evaluated in patients with advanced bladder cancer. Since selective mTORC1 inhibition may lead to feedback activation of Akt through mTORC2, concomitant disruption of mTORC2 activity may result in more complete mTOR blockade and more potent antitumor activity than inhibition of mTORC1 alone. In this study, the efficacy of the dual mTORC1/mTORC2 inhibitor AZD8055 was compared with that of rapamycin in three UC cell lines UMUC-3, TCCSuP and HT-1376. Both AZD8055 and rapamycin were able to downregulate the mTORC1 substrate pS6; however, only AZD8055 was effective in downregulating p4E-BP1, a critical component of cap-dependent translation that is also regulated by mTORC1. AZD8055, but not rapamycin, potently suppressed mTORC2 signaling as evidenced by downregulation of pAKTs473. AZD8055 exhibited potent in vitro antitumor activity against all three bladder cancer cell lines, with IC50s of 15-40nM by the MTT assay, while rapamycin had minimal antitumor activity at these concentrations (IC50 not reached at 1uM). In vivo efficacy of AZD8055 is under evaluation in mouse xenograft models. These data demonstrate that AZD8055 is a potent inhibitor of mTORC2 and a more effective inhibitor of downstream mTORC1 targets than rapamycin. Combined mTORC1/2 kinase inhibition may be superior to selective mTORC1 inhibition, and is worthy of clinical evaluation in urothelial carcinoma of the bladder. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4493. doi:10.1158/1538-7445.AM2011-4493
Holographic polymer-dispersed liquid crystal grating with low scattering losses (2012)

A simple method to fabricate low-scattering holographic polymer-dispersed liquid crystal grating is proposed. The optical efficiencies of the grating are tested. The results show that the scattering losses are almost totally suppressed, at less than 0.25%, and the diffraction efficiency of the grating reaches as high as 99%, indicating a great improvement compared with grating fabricated in the conventional way. In addition, the electro-optical performance maintains good behaviour, and thermo-stability testing shows that the good optical properties of the grating can be maintained in a relatively wide temperature range, satisfying the application requirements of displays and other optical instruments.
Single-course specific immunotherapy with mixed pollen allergoids: results of a multi-centre study (2003)

The treatment of pollen-allergic patients with a short-term SIT using a 6-injection pollen allergoid/L-tyrosine vaccine in a clinical practice setting provided a high level of efficacy with a low incidence of mainly mild adverse events.
Poor relationship between arterial [lactate] and leg net release during exercise at 4,300 m altitude (1998)

We evaluated the hypotheses that on acute exposure to hypobaric hypoxia, sympathetic stimulation leads to augmented muscle lactate production and circulating [lactate] through a beta-adrenergic mechanism and that beta-adrenergic adaptation to chronic hypoxia is responsible for the blunted exercise lactate response after acclimatization to altitude. Five control and 6 beta-blocked men were studied during rest and exercise at sea level (SL), on acute exposure to 4,300 m (A1), and after a 3-wk sojourn at altitude (A2). Exercise was by leg cycling at 49% of SL peak O2 consumption (VO2 peak) (65% of altitude VO2 peak or 87 +/- 2.6 W); beta-blockade was by propranolol (80 mg 3x daily), femoral arterial and venous blood was sampled; leg blood flow (Q) was measured by thermodilution, leg lactate net release [ = (2) (1-leg Q) venous-arterial concentrationL] was calculated, and vastus lateralis needle biopsies were obtained. Muscle [lactate] increased with exercise and acute altitude exposure but regressed to SL values with acclimatization; beta-blockade had no effect on muscle [lactate]. Arterial [lactate] rose during exercise at SL (0.9 +/- 0.1 to 1.5 +/- 0.3 mM); exercise at A1 produced the greatest arterial [lactate] (4.4 +/- 0.8 mM), and exercise at A2 an intermediate response (2.1 +/- 0.6 mM). beta-Blockade reduced circulating [lactate] approximately 45% during exercise under all altitude conditions. increased transiently at exercise onset but then declined over time under all conditions. Blood and muscle "lactate paradoxes" occurred independent of beta-adrenergic influences, and the hypotheses relating the blood lactate response at altitude to beta-adrenergic mechanisms are rejected. During exercise at altitude, arterial [lactate] is determined by factors in addition to hypoxemia, circulating epinephrine, and net lactate release from active muscle beds.
Maintaining multiple views in feature modeling (1997)

Article Free Access Share on Maintaining multiple views in feature modeling Authors: Klaas Jan de Kraker Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The Netherlands Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The NetherlandsView Profile , Maurice Dohmen Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The Netherlands Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The NetherlandsView Profile , Willem F. Bronsvoort Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The Netherlands Faculty of Technical Mathematics and Informatics, Delft University of Technology, Zuidplantsoen 4, NL-2628 BZ Delft, The NetherlandsView Profile Authors Info & Claims SMA '97: Proceedings of the fourth ACM symposium on Solid modeling and applicationsMay 1997 Pages 123–130https://doi.org/10.1145/267734.267765Published:01 May 1997Publication History 25citation439DownloadsMetricsTotal Citations25Total Downloads439Last 12 Months10Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Treatment of Alzheimer's disease across the spectrum of severity (2006)

Alzheimer's disease (AD) is the most common cause of dementia affecting nearly 18 million people around the world and 4.5 million in the US. It is a progressive neurodegenerative condition that is estimated to dramatically increase in prevalence as the elderly population continues to grow. As the cognitive and neuropsychiatric signs and symptoms of AD progresses in severity over time, affected individuals become increasingly dependent on others for assistance in performing all activities of daily living. The burden of caring for someone affected by the disorder is great and has substantial impact on a family's emotional, social and financial well-being. In the US, the currently approved medications for the treatment of mild to moderate stages of AD are the cholinesterase inhibitors (ChEIs). Cholinesterase inhibitors have shown modest efficacy in terms of symptomatic improvement and stabilization for periods generally ranging from 6 to 12 months. There are additional data that have emerged, which suggest longer-term benefits. For the moderate to severe stages of AD, memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist is in widespread use and has shown modest benefit as monotherapy and in combination with ChEIs. The cost effectiveness of the currently available therapeutic agents for AD has undergone great scrutiny and remains controversial, especially outside the US. Neuropsychiatric symptoms such as agitation and psychosis are common in AD. Unfortunately, in the US there are no Food and Drug Administration (FDA)-approved agents for the treatment of these symptoms, although atypical antipsychotics have shown some efficacy and have been widely used. However, the use of these agents has recently warranted special caution due to reports of associated adverse effects such as weight gain, hyperlipidemia, glucose intolerance, cerebrovascular events, and an increased risk for death. Alternative agents used to treat neuropsychiatric symptoms include serotonergic antidepressants, benzodiazepines, and anticonvulsant medications.
The effects of voice disguise upon formant transition (2005)

The second degree polynomial approximation coefficients of formant transition and transition duration, as the speaker specific aspects, have been studied under normal and diguised speech conditions. The speech material in this study consists of 10 segments occuring in a text read by twenty speakers. The selected disguise condition includes: a) heightened voice, b) lowered voice, c) pinched nose, which are frequently found in criminalistic cases. The most important results are: a) The approximation coefficients and transition duration are more different among the speakers than among the speech conditions. b) There are regular deviation trends for formant transitions from one speech condition to the others. c) The transition duration and the approximation coefficients can be used to identify speaker.
Causes and Effects of My Disturbing Little Book (1986)

Review and reflection indicate that no more than 5% of what was written in the 1954 book entitled, Clinical Versus Statistical Prediction (Meehl, 1984), needs to be retracted 30 years later. If anything, these retractions would result in the book's being more actuarial than it was. Seven factors appear to account for the failure of mental health professionals to apply in practice the strong and clearly supported empirical generalizations demonstrating the superiority of actuarial over clinical prediction.
Enzymic transglucosylation of rubusoside and the structure-sweetness relationship of steviol-bisglycosides. (1984)

Rubusoside, the β-D-glucosyl ester of 13-O-β-D-glucosyl-steviol which was isolated from leaves of Rubus suavissimus collected in China as the major sweet principle (yield : 5.4%), was subjected to α-14 transglucosylation with the cyclodextrin glucosyltransferase produced by Bacillus megaterium Strain No. 5 using soluble starch as a donor. A significant improvement in the quality of sweetness was observed for the crude reaction mixture, which was separated into mono-, di-, tri-, tetra-, penta-, and hexa-glucosylated products. All isomers of the mono- and di-glucosylated products were further separated. Evaluation of the sweetness of these products compared with stevioside, rebaudioside A, etc. disclosed that the ratio of the number of glucose units at the 13-hydroxyl group to that at 19-carboxyl group seems to have a significant relationship with the sweetness as well as the quality of taste for glucosides of this type.
Multilayer technique for fabricating Nb junction circuits exhibiting charging effects (1999)

A reliable process has been developed for the fabrication of all Nb single-electron circuits, based on spin-on glass planarization. The process steps are the in situ growth of Nb/AlOx/Nb sandwich, definition of the patterns of junctions, base electrodes, and wiring by use of reactive ion etching and the planarization of a spin-on glass insulation between base electrode and wiring. A single-electron transistor made of 0.3×0.3 μm2 area junctions clearly shows the e-periodic Coulomb blockade modulation by a voltage applied to a gate.
On optimal constellations for BICM at low SNR (2009)

In this paper we study the problem of finding capacity-maximizing constellations in BICM for asymptotically low signal-to-noise ratios (SNRs). We base our analysis on the so-called Hadamard transform and on a linear approximation of the BICM capacity for asymptotically low SNRs. We fully characterize the set of constellations, input distributions, and binary labelings that achieve Shannon's limit E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">b</sub> /N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> = -1.59 dB. For equiprobable input distributions, a constellation achieves this limit if and only if it is a linear projection of a hypercube.
Case studies in Web-controlled devices and remote manipulation-laboratory based distance learning (2003)

The concept of distance learning has been more and more articulated during the past few years and is expected to shortly turn into a practical education system within current high level learning institutions. The chances are that distance learning would transparently extend colleges and institutes of education, and could plausibly overtake and turn into a preferred choice of higher education, especially for adult and working students. In a supportive effort towards faster distance learning implementation and consideration, this material presents a sequence of projects that have been developed at University of Bridgeport and can serve very well in the process of distance learning education, ranging from simple "hobby" style training to professional guidance material, The projects have an engineering/laboratory flavor, are part of an ongoing work of the faculty and students of the Computer Science and Engineering Department of the University, and are being presented in an arbitrary order, topics ranging from vision and sensing to engineering design, scheduling, remote control and operation.
Polymorphism of Aldehyde Dehydrogenase andAlcohol Sensitivity (1987)

The metabolism of acetaldehyde has received considerable attention in the past years owing to its acute and chronic toxic effects in humans. Aldehyde dehydrogenase (ALDH) catalyzes the oxidation of acetaldehyde in liver and other organs. Two major isozymes of hepatic ALDH (ALDH I or E2 and ALDH II or E1), which differ in their structural and functional properties, have been characterized in humans. The ALDH I with a low Km for acetaldehyde is predominantly of mitochondrial origin and ALDH II which has a relatively higher Km is of cytosolic origin. An inherited deficiency of ALDH I isozyme has been found among Japanese and Chinese which is primarily responsible for producing acute alcohol sensitivity symptoms (flushing response) after drinking mild doses of alcohol. Biochemical, immunochemical and molecular genetics data indicate a structural mutation in the ALDH I isozyme gene responsible for the loss in catalytic activity. Population genetic studies indicate a wide prevalence of this ALDH polymorphism among individuals of Mongoloid race. Flushing response to alcohol shows familial resemblances and preliminary family data from Japan, China and Korea hint to an autosomal codominant inheritance for ALDH I isozyme deficiency. The ALDH polymorphism is apparently responsible for the low incidence of alcoholism in Japanese, Chinese and Koreans. Alcohol-induced sensitivity due to ALDH isozyme deficiency may act as an inhibitory factor against excessive alcohol drinking thereby imparting a protection against alcoholism.
Boron Nitride Powders Formed by Aerosol Decomposition of Poly(borazinylamine) Solutions (1991)

Micrometer‐sized aerosol droplets of a liquid ammonia solution of poly(borazinylamine) were formed in a nitrogen carrier gas by using an aerosol generator. The resulting droplets were thermally decomposed in a flow reactor at 1000°C. The white powder obtained was amorphous to X‐rays and spherical with particle sizes on the order of 0.5 μm. The particles at this stage were porous, and some appeared to exhibit a hollow‐shell morphology. Subsequent calcining at 1600°C yielded dense, crystalline boron nitride powder with partial sintering.
Background checks on students and faculty? (2009)

Jones, Melinda Mitchell RN, MSN, JD; Boswell, Carol RN, EdD; Cannon, Sharon RN, EdD Author Information
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. (1990)

The mammary tumor-associated proto-oncogene Wnt-1/int-1 encodes a secreted protein implicated in the regulation of neural development in vertebrates and segmental pattern in Drosophila. Using a PCR-based strategy, we isolated cDNAs encoding six novel, related proteins that are expressed in fetal mice. Predicted proteins are of similar molecular masses (38-42 kD) and share between 50% and 85% of amino acids. All contain a putative hydrophobic signal sequence, and comparative analysis reveals 83 absolutely conserved amino acid residues, including 21 cysteines. Transcripts were detected throughout fetal development by Northern blot analysis. Detailed examination of the expression of two of these genes by in situ hybridization revealed complex temporal and spatial patterns of transcription. All new Wnt family members are expressed in adult tissues, particularly in brain and lung. These data support the view that the Wnt-1/int-1 family constitutes a large family of signaling peptides with diverse roles in mouse development.