gebhart/patrepeval huggingface dataset:
Rationale for maintenance or consolidation therapy in ovarian cancer. (2003)

Despite the high objective response rare of advanced ovarian cancer to platinum-based chemotherapy, relapse is common and most patients ultimately experience disease progression. These data lead to the hypothesis that extending treatment beyond the standard 6 cycles may improve both progression-free and overall survival in a patient population demonstrated to have exhibited major inherent chemosensitivity to the primary chemotherapy program. A preliminary analysis of a randomized phase III trial conducted by the Southwest Oncology Group and the Gynecologic Oncology Group has revealed that 12 monthly cycles of single-agent paclitaxel delivered to patients with advanced ovarian cancer who have attained a clinically defined complete response to initial platinum/paclitaxel chemotherapy results in a highly statistically significant reduction in the risk of recurrence. This proof of principle study should lead to further investigation in defining an optimal maintenance or consolidation strategy for the treatment of women with advanced ovarian cancer.
Nucleotide sequence of the xth gene of Escherichia coli K-12 (1988)

The xth gene of Escherichia coli K-12, which encodes exonuclease III, has been sequenced. Exonuclease III from a cloned copy of the E. coli K-12 gene has been purified and characterized. The molecular weight (30,921), the amino-terminal amino acid sequence, and the amino acid composition of the polypeptide predicted from the nucleotide sequence are in excellent agreement with those properties determined for the purified enzyme. The xth promoter was mapped by primer extension of in vivo transcripts. Inspection of the nucleotide sequence reveals that a region of dyad symmetry which could form a hairpin stem-loop structure in RNA characteristic of a rho-dependent terminator lies immediately downstream from the xth gene.
Motion Prediction of Traffic Actors for Autonomous Driving using Deep Convolutional Networks. (2018)

Recent algorithmic improvements and hardware breakthroughs resulted in a
number of success stories in the field of AI impacting our daily lives.
However, despite its ubiquity AI is only just starting to make advances in what
may arguably have the largest impact thus far, the nascent field of autonomous
driving. In this work we discuss this important topic and address one of
crucial aspects of the emerging area, the problem of predicting future state of
autonomous vehicle's surrounding necessary for safe and efficient operations.
We introduce a deep learning-based approach that takes into account current
state of traffic actors and produces rasterized representations of each actor's
vicinity. The raster images are then used by deep convolutional models to infer
future movement of actors while accounting for inherent uncertainty of the
prediction task. Extensive experiments on real-world data strongly suggest
benefits of the proposed approach. Moreover, following successful tests the
system was deployed to a fleet of autonomous vehicles.
Soybean Aphid Biology in North America (2004)

Soybean aphid, Aphis glycines Matsumura, a native of eastern Asia, was first discovered in North America in July 2000 in Wisconsin and subsequently in a total of 10 North Central U.S. states by September 2000. Currently, soybean aphid has spread to 20 U.S. states and three Canadian provinces, putting >60 million acres of soybean at risk to crop injury caused by this exotic insect. The life history of this species has been studied by a number of entomologists and crop protection specialists, and here we provide a summary of the observations made by ourselves and our colleagues. The soybean aphid has been observed at all stages of a heterecious holocyclic life cycle and seems to be adapting to a large geographic area of the North Central United States. Soybean aphid uses native and exotic primary hosts found in North America, specifically Rhamnus cathartica L. and Rhamnus alnifolia L’Hér. The aphid’s principal secondary host is soybean, Glycine max (L.) Merr., but there seems to be a lengthy gap in early spring between the production of alatae on buckthorn (Rhamnus spp.) and the occurrence of soybean. In the fall when soybean is senescing, a biological bottleneck is created as the aphid must develop sexual morphs on soybean that emigrate back to the primary host to complete the sexual phase of its life cycle. During the summer, A. glycines is prone to develop winged morphs during any generation on soybean, which puts much of the soybean crop at risk of invasion by this exotic species, even if the insect does not overwinter locally. The integrated pest management challenges presented by the aphid require a deeper understanding of its biology as it adapts to North America.
Optical coherence elastography for strain dynamics measurements in laser correction of cornea shape (2017)

We describe the use of elastographic processing in phase-sensitive optical coherence tomography (OCT) for visualizing dynamics of strain and tissue-shape changes during laser-induced photothermal corneal reshaping, for applications in the emerging field of non-destructive and non-ablative (non-LASIK) laser vision correction. The proposed phase-processing approach based on fairly sparse data acquisition enabled rapid data processing and near-real-time visualization of dynamic strains. The approach avoids conventional phase unwrapping, yet allows for mapping strains even for significantly supra-wavelength inter-frame displacements of scatterers accompanied by multiple phase-wrapping. These developments bode well for real-time feedback systems for controlling the dynamics of corneal deformation with 10-100 ms temporal resolution, and for suitably long-term monitoring of resultant reshaping of the cornea. In ex-vivo experiments with excised rabbit eyes, we demonstrate temporal plastification of cornea that allows shape changes relevant for vision-correction applications without affecting its transparency. We demonstrate OCT's ability to detect achieving of threshold temperatures required for tissue plastification and simultaneously characterize transient and cumulative strain distributions, surface displacements, and scattering tissue properties. Comparison with previously used methods for studying laser-induced reshaping of cartilaginous tissues and numerical simulations is performed.
Digital Amplitude-Phase Keying with M-Ary Alphabets (1974)

Signal sets employing amplitude and phase keying (APK) with large alphabets conserve bandwidth and do not require as high a signal-to-noise ratio (SNR) as phase-shift keying (PSK). Twenty-nine empirically generated APK sets with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> -ary alphabet sizes from 4 to 128 are investigated to determine optimum designs. Selected sets are compared on the basis of a symbol-error-probability bound for both average and peak SNR. Results are presented in the form of symbol error curves. The degradation caused by nonlinearities in a typical TWT amplifier is examined. The effects of AM-AM and AM-PM distortion on APK are presented as a function of power backoff for single-carrier operation (when APK is at the greatest disadvantage compared with PSK). Modem implementation methods, including carrier phase reconstruction techniques, are discussed for basic APK designs.
Krypton fluoride excimer laser for advanced microlithography (1993)

The excimer-laser-based stepper is now expected to play a significant role in the manufacturing of ULSI devices requiring sub-0.4-μm design rule features. They will be used in a mix-and-match strategy along with high NA <i>i</i>-line steppers for critical layers in the production of 64-Mbit dynamic random access memory (DRAM) generation of IC devices. This is supported by the present availability of a number of production worthy high-NA, wide-field excimer stepper models, along with the recent introduction of several process worthy and moderate cost, positive tone deep-UV photoresists. The excimer laser for the stepper, since its introduction in 1987, has evolved from a laboratory instrument to fully production worthy fab-line equipment. The status of such a laser is discussed. We will discuss the operating theory and the design features of an excimer laser; in particular, the discharge chamber, spectral narrowing module, and the wavemeter. Some of the latest technical innovations incorporated into the laser that reduce maintenance intervals and increase reliability are also presented. Finally we will present and discuss the performance specifications of a current production lithography excimer laser.
Synchrophasor Applications of the National Electric System Operator of Spain (2008)

This paper examines a series of PMU (Phasor Measurement Unit) applications devised by the National Electric System Operator of Spain (Red Electrica de España - REE) including calculation of the sequence impedances of power lines, fault location in mixed lines, and monitoring of the system dynamic behavior. The paper covers in detail the problems of traditional algorithms and explains the advantages of the new algorithms based on synchrophasors. Examples include actual data from the grid.
LIRS (2002)

Although LRU replacement policy has been commonly used in the buffer cache management, it is well known for its inability to cope with access patterns with weak locality. Previous work, such as LRU-K and 2Q, attempts to enhance LRU capacity by making use of additional history information of previous block references other than only the recency information used in LRU. These algorithms greatly increase complexity and/or can not consistently provide performance improvement. Many recently proposed policies, such as UBM and SEQ, improve replacement performance by exploiting access regularities in references. They only address LRU problems on certain specific and well-defined cases such as access patterns like sequences and loops. Motivated by the limits of previous studies, we propose an efficient buffer cache replacement policy, called Low Inter-reference Recency Set (LIRS). LIRS effectively addresses the limits of LRU by using recency to evaluate Inter-Reference Recency (IRR) for making a replacement decision. This is in contrast to what LRU does: directly using recency to predict next reference timing. At the same time, LIRS almost retains the same simple assumption of LRU to predict future access behavior of blocks. Our objectives are to effectively address the limits of LRU for a general purpose, to retain the low overhead merit of LRU, and to outperform those replacement policies relying on the access regularity detections. Conducting simulations with a variety of traces and a wide range of cache sizes, we show that LIRS significantly outperforms LRU, and outperforms other existing replacement algorithms in most cases. Furthermore, we show that the additional cost for implementing LIRS is trivial in comparison with LRU.
Rearrangement of 14β-Hydroxy-12β-sulfoxy-steroids to 13,17-Seco-12,17-cyclo-steroids; a 2D-NMR Analysis (1985)

Abstract The rearrangement of 3-oxo-14β-hydroxy-12β-methanesulfoxy-card-20(22)-enolide and 14β-hydroxy-12β-methanesulfoxy-pregnane-3,20-dione during elimination of the sulfoxygroups was studied. By means of 2D-NMR analysis the structures were determined as 13,17-seco-12,17-cyclo-steroids.
Identifying Children With Poor Cochlear Implantation Outcomes Using Massively Parallel Sequencing (2015)

Cochlear implantation is currently the treatment of choice for children with severe to profound hearing impairment. However, the outcomes with cochlear implants (CIs) vary significantly among recipients. The purpose of the present study is to identify the genetic determinants of poor CI outcomes. Twelve children with poor CI outcomes (the "cases") and 30 "matched controls" with good CI outcomes were subjected to comprehensive genetic analyses using massively parallel sequencing, which targeted 129 known deafness genes. Audiological features, imaging findings, and auditory/speech performance with CIs were then correlated to the genetic diagnoses. We identified genetic variants which are associated with poor CI outcomes in 7 (58%) of the 12 cases; 4 cases had bi-allelic PCDH15 pathogenic mutations and 3 cases were homozygous for the DFNB59 p.G292R variant. Mutations in the WFS1, GJB3, ESRRB, LRTOMT, MYO3A, and POU3F4 genes were detected in 7 (23%) of the 30 matched controls. The allele frequencies of PCDH15 and DFNB59 variants were significantly higher in the cases than in the matched controls (both P < 0.001). In the 7 CI recipients with PCDH15 or DFNB59 variants, otoacoustic emissions were absent in both ears, and imaging findings were normal in all 7 implanted ears. PCDH15 or DFNB59 variants are associated with poor CI performance, yet children with PCDH15 or DFNB59 variants might show clinical features indistinguishable from those of other typical pediatric CI recipients. Accordingly, genetic examination is indicated in all CI candidates before operation.
Multimedia learning: Are we asking the right questions? (1997)

How can we help students to understand scientific explanations of cause-and-effect systems, such as how a pump works, how the human respiratory system works, or how lightning storms develop? One promising approach involves multimedia presentation of explanations in visual and verbal formats, such as presenting computer-generated animations synchronized with computer-generated narration or presenting illustrations next to corresponding text. In a review of eight studies concerning whether multimedia instruction is effective, there was consistent evidence for a multimedia effect: Students who received coordinated presentation of explanations in verbal and visual format (multiple representation group) generated a median of over 75% more creative solutions on problem-solving transfer tests than did students who received verbal explanations alone (single representation group). In a review of 10 studies; concerning when multimedia instruction is effective, there was consistent evidence for a contiguity effect: Students generated a median of over 50% more creative solutions to transfer problems when verbal and visual explanations were coordinated (integrated group) than when they were not coordinated (separated group). Finally, in a review of six studies concerning for whom multimedia instruction is effective, Attribute x Treatment interactions indicated that multimedia and contiguity effects were strongest for low prior knowledge and high spatial ability students. Results are consistent with a generative theory of multimedia learning in which learners actively select, organize, and integrate verbal and visual information.
Benzoxocin and benzoxonin derivatives. Novel groups of terpenophenols with central nervous system activity. Correction (1975)

The structure of a compound previously reported as 2,3,4,5,6,7-hexahydro-2,2-dimethyl-8-hydroxy-6-methyl-10-pentyl-3,7-methano-1-benzoxonin (1) is shown to be actually 3,4,5,6-tetrahydro-7-hydroxy-2-methyl-5-isopropyl-9-pentyl-2,6-methano-2H-1-benzoxocin (2a).
Characterization of Intracellular Reverse Transcription Complexes of Moloney Murine Leukemia Virus (1999)

To examine the early events in the life cycle of Moloney murine leukemia virus (MoMLV), we analyzed the intracellular complexes mediating reverse transcription. Partial purification of the reverse transcription complexes (RTCs) by equilibrium density fractionation and velocity sedimentation indicated that three distinct species of intracellular complexes are formed shortly after cell infection. Only one of these species is able to start and complete reverse transcription in the cell cytoplasm. This RTC is composed of at least the viral genome, capsid, integrase, and reverse transcriptase proteins. The RTC becomes permeable to micrococcal nuclease but not to antibodies. Shortly after initiation of reverse transcription, the viral strong stop DNA within the RTC is protected from nuclease digestion. The sedimentation velocity of the RTC decreases during reverse transcription. After entry into the nucleus, most capsid proteins are lost from the RTC and its sedimentation velocity decreases further.
Mutational and immunochemical analysis of plasminogen activator inhibitor 1. (1990)

We have undertaken a structural and functional analysis of recombinant plasminogen activator inhibitor type 1 (PAI-1) produced in Escherichia coli using site-directed mutagenesis and immunochemistry. Expression of recombinant PAI-1 yielded an inhibitor that was functionally indistinguishable from PAI-1 made in human endothelial cells. Mutations in both the reactive center P1 and P1' residues (Arg-Met) and a putative secondary binding site for plasminogen activators on PAI-1 have been engineered to assess their functional effects. The inhibition of a panel of serine proteases, including plasminogen activators, trypsin, elastase, and thrombin, has been studied. Substitution of the P1 arginine residue with lysine or the P1' residue with either valine or serine had no detectable effect on the rate of inhibition of plasminogen activators. However, replacement of both P1 and P1' by Met-Ser produced a variant with no detectable plasminogen activator inhibitor activity. Mutations introduced into either Asp102 or Lys104 in the second site did not affect the rate of inhibition of plasminogen activators. Complementary immunochemical experiments using antibodies directed against the same two regions of the PAI-1 protein confirm that the reactive center is the primary determinant of inhibitory activity and that the putative second site is not a necessary functional region.
Recovery of gold from computer circuit board scrap using aqua regia (2007)

Computer circuit board scrap was first treated with one part concentrated nitric acid and two parts water at 70 degrees C for 1 h. This step dissolved the base metals, thereby liberating the chips from the boards. After solid-liquid separation, the chips, intermixed with some metallic flakes and tin oxide precipitate, were mechanically crushed to liberate the base and precious metals contained within the protective plastic or ceramic chip cases. The base metals in this crushed product were dissolved by leaching again with the same type of nitric acid-water solution. The remaining solid constituents, crushed chips and resin, plus solid particles of gold, were leached with aqua regia at various times and temperatures. Gold was precipitated from the leachate with ferrous sulphate.
Cerebral arterial innervation by nerve fibers containing calcitonin gene‐related peptide (CGRP): I. Distribution and origin of CGRP perivascular innervation in rat (1988)

The origin, density and distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in cerebral perivascular nerves and the trigeminal ganglion of rats were examined in this study. CGRP immunoreactive axons were abundant on the walls of the rostral circulation of the major cerebral arteries in the circle of Willis. The fibers form a grid- or meshwork of longitudinal and circumferential axons studded with numerous varicose swellings. The density of CGRP fibers was particularly high at the bifurcation of major arteries. A few CGRP fibers cross the midline to innervate arteries on the contralateral side of the arterial tree. The arteries of the caudal circulation were sparsely innervated by CGRP fibers. In the trigeminal ganglion, about 30% of the ganglion cells had CGRP immunoreactivity. The cell size of most (75%) of CGRP neurons was less than 30 micron in diameter. There was no significant difference in staining density between small and large CGRP neurons. Unilateral transection of the maxillary and mandibular divisions of the trigeminal nerve caused a substantial decrease of CGRP immunoreactivity in the ipsilateral dorsal two-thirds of the trigeminal nucleus and cervical spinal cord but did not noticeably change the diameter of the vascular lumen or the densities of CGRP fibers in the walls of the cerebral arteries. In contrast, unilateral transection that included the ophthalmic division eliminated CGRP fibers on the ipsilateral cerebral arteries and eliminated CGRP immunoreactivity throughout the trigeminal nucleus in the brainstem and rostral cervical cord. In addition, these lesions caused a significant reduction in the diameter of the denervated arteries. The present study demonstrates that CGRP, a putative neurotransmitter/neuromodulator, is especially abundant in the rostral cerebral circulation and is derived from the ipsilateral ophthalmic division of the trigeminal nerve. In addition, the loss of CGRP perivascular nerves is associated with a reduction of the arterial lumen. This suggests that CGRP is a strong candidate as a nerve-derived trophic factor at trigeminal terminals and provides additional evidence that CGRP is a component in the trigeminovascular system influencing vascular diameter.
Ability of Prenylflavanones Present in Hops to Induce Apoptosis in a Human Burkitt Lymphoma Cell Line (2007)

The identification of effective cancer preventive compounds from hops has become an important issue in public health-related research. We compared the antiproliferative and apoptosis-inducing effects of side chain variants of prenylflavanones, e. g., 8-prenylnaringenin (7) and 8-geranylnaringenin (10), which have been identified in hops (Humulus lupulus), and their synthetic variations 8-furanmethylnaringenin (8) and 8-cinnamylnaringenin (9). These were accessible by a Mitsunobu reaction and Claisen rearrangement. Flavanones 9 and 10 showed cytotoxic and apoptotic activities. Apoptosis was induced in a mitochondrial dependent manner. 8-Cinnamylnaringenin (9) displayed noticeably improved apoptotic effects when compared to 8-prenylnaringenin. The potential of 8-prenylnaringenin (7) is shown in an ex vivo experiment on a multi-drug resistant leukaemia blast.