gebhart/patrepeval huggingface dataset:
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling (2009)

Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from conventional antioxidants, including a susceptibility to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures. These properties, combined with a high cellular abundance and reactivity with hydrogen peroxide, have led to speculation that the Prxs function as redox sensors that transmit signals as part of the cellular response to oxidative stress. Multicellular organisms express several different Prxs that can be categorized by their subcellular distribution. In mammals, Prx 3 and Prx 5 are targeted to the mitochondrial matrix. Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies. Hydrogen peroxide can also act as a second messenger, and is linked with signalling events in mitochondria, including the induction of apoptosis. A simple kinetic competition analysis estimates that Prx 3 will be the target for up to 90% of hydrogen peroxide generated in the matrix. Therefore, mitochondrial Prxs have the potential to play a major role in mitochondrial redox signalling, but the extent of this role and the mechanisms involved are currently unclear.
Osteonecrosis of the Femoral Head (1989)

The effectiveness of core decompression and bone grafting with and without electrical stimulation was investigated in patients with avascular necrosis (AVN) of the femoral head. One hundred sixteen hips with AVN had decompression and grafting; 74 were also treated with direct current (DC). The DC stimulation was via a coil inserted directly into the femoral head. These were compared to 55 hips with AVN treated nonoperatively. Hips treated with electrical stimulation showed less roentgenographic progression and achieved a better clinical score than hips treated with decompression and grafting alone. Both groups had a significantly lower incidence of arthroplasty than the nonoperated controls. One patient developed a pulmonary embolus, but there were no fractures or other complications. Decompression and grafting are safe and reasonably effective in retarding the progression of AVN. Supplemental electrical stimulation seems to improve the results even further.
High-pressure polyol synthesis of ultrathin silver nanowires: Electrical and optical properties (2013)

Silver nanowires whose diameters could be controlled in the range of 15–30 nm and lengths up to ∼20 μm were prepared by the high-pressure polyol method. The first step involved the formation of Ag nanoparticles by reducing silver nitrate in the presence of NaCl and KBr with ethylene glycol. At the growing step, the adjustable reaction pressure controls the diameter of the silver nanowires, which were in the range 15–22 nm when the pressure was 200 psi. These Ag nanowires showed an electrical conductivity of 0.4 × 105 S/cm, and the intensity of scattered light and the optical transmittance were largely improved.
Serological analysis of species specificity in the high mobility group chromosomal proteins. (1979)

The non-histone chromosomal protein of the high mobility group (HMG-1) present in mouse liver was purified to homogeneity. Antibodies against this protein as well as pure HMG-1 derived from calf thymus and HMG-E purified from duck erythrocytes were elicited in rabbits. The interaction between the antibodies and the immunogens was measured by passive hemoagglutination and by quantitative microcomplement fixation. Quantitative microcomplement fixation assays revealed that the immunological distance between HMG-1 from calf thymus and HMG-1 from mouse liver and duck erythrocytes was 15. This corresponds to 3% sequence differences. It was estimated that amino acid substitution occurred at about seven positions in the polypeptide chain. Thus, HMG-1 proteins display remarkable evolutionary conservation in their primary sequence, similar to that displayed by histones H4 and H3, suggesting that their biological function is dependent on stringent structural requirements. HMG-E protein is significantly different from both HMG-1 and HMG-2 derived from calf thymus. As such, it is a protein unique to avian erythrocytes.
Body-Image Syndromes in Sexology (1994)

No abstract available for this article.
Isolation and functional characterization of fatty acid Δ5‐elongase gene from the liverwort Marchantia polymorpha L (2005)

Bryophyte Marchantia polymorpha L. produces C22 very-long-chain polyunsaturated fatty acid (VLCPUFA). Thus far, no enzyme that mediates elongation of C20 VLCPUFAs has been identified in land plants. Here, we report the isolation and characterization of the gene MpELO2, which encodes an ELO-like fatty acid elongase in M. polymorpha. Heterologous expression in yeast demonstrated that MpELO2 encodes delta5-elongase, which mediates elongation of arachidonic (20:4) and eicosapentaenoic acids (20:5). Phylogenetic and gene structural analysis indicated that the MpELO2 gene is closely related to bryophyte Delta6-elongase genes for C18 fatty acid elongation and diverged from them by local gene duplication.
Impact of Electric Vehicles on power quality in a Smart Grid context (2011)

The large dependency of the imported fossil fuels and the soaring oil prices, makes essential the look for alternatives to the traditional people transportation system. The natural bet is the electric mobility, namely Electric Vehicles (EV), and Plug-in Hybrid Electric Vehicles (PHEV). This way, in this paper is analyzed the potential impacts of the battery charging systems on the grid power quality, in a Smart Grid context. It is considered the current consumed, according to a typical electric consumption profile, and the voltage degradation for a large number of houses. Two different types of EV batteries chargers were considered: a traditional charger; and a smart charger with sinusoidal current consumption and unitary power factor. It presents simulation results of the integration of EVs and PHEVs in terms of power quality, and experimental results of a smart charger which was specially developed for EV charging and that allows mitigation of the power quality degradation.
Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor (2007)

IGF-IR expression is detectable by immunofluorescence on CTCs. These data support the further evaluation of CTCs in pharmacodynamic studies and patient selection, particularly in advanced prostate cancer.
Expression of Periostin, Homologous with an Insect Cell Adhesion Molecule, as a Prognostic Marker in Non‐small Cell Lung Cancers (2001)

We used our palindromic polymerase chain reaction (PCR)-driven cDNA differential display technique to identify and isolate a gene, designated periostin, from cancer tissues and found it to be overexpressed in several human tumors. We attempted to determine the influence of periostin expression on clinical outcome in patients with non-small cell lung cancer (NSCLC) by reverse transcriptase (RT)-PCR analysis. Periostin gene was highly expressed at the tumor periphery of lung cancer tissue but not within the tumor by in situ RNA hybridization, suggesting that expression of periostin may be involved in the process of tumor invasion. Periostin transcripts were detected in 50 (49.0%) of the tumor samples, although some paired normal lung samples showed weak expression. There was no relationship between periostin gene expression and gender, N- or T-status. The NSCLC patients with periostin expression had significantly poorer survival than the patients without periostin expression (P = 0.0338).
Two Diastereoisomers of 2-(Benzenesulfonyl)-5-benzoyl-1-oxo-3-phenyl-2,5-diazaspiro[3.4]octan-7-yl Acetate (1998)

The structures of two diastereoisomers of the title compound, C27H24N2O6S, were determined by single-crystal diffractometry. The two molecules are very similar as far as bond distances and angles are concerned, but more substantial differences are observed in some torsion angles.
Photoactivation of Channelrhodopsin (2007)

Channelrhodopsins (ChRs) are light-gated ion channels that control photomovement of microalgae. In optogenetics, ChRs are widely applied for light-triggering action potentials in cells, tissues, and living animals, yet the spectral properties and photocycle of ChR remain obscure. In this study, we cloned a ChR from the colonial alga Volvox carteri, VChR. After electrophysiological characterization in Xenopus oocytes, VChR was expressed in COS-1 cells and purified. Time-resolved UV-visible spectroscopy revealed a pH-dependent equilibrium of two dark species, D(470)/D(480). Laser flashes converted both with tau approximately 200 mus into major photointermediates P(510)/P(530), which reverted back to the dark states with tau approximately 15-100 ms. Both intermediates were assigned to conducting states. Three early intermediates P(500)/P(515) and P(390) were detected on a ns to mus time scale. The spectroscopic and electrical data were unified in a photocycle model. The functional expression of VChR we report here paves the way toward a broader structure/function analysis of the recently identified class of light-gated ion channels.
Fabrication of Robust Biomolecular Patterns by Reactive Microcontact Printing on N‐Hydroxysuccinimide Ester‐Containing Polymer Films (2006)

Abstract The fabrication of robust biomolecule microarrays by reactive microcontact printing (μCP) on spin‐coated thin films of poly( N ‐hydroxysuccinimidyl methacrylate) (PNHSMA) on oxidized silicon and glass is described. The approach combines the advantages of activated polymer thin films as coupling layers, characterized by high reactivity and high molecular loading, with the versatility and flexibility of soft lithography. The transfer of amino end‐functionalized poly(ethylene glycol) (PEG) from oxidized poly(dimethylsiloxane) elastomer stamps to PNHSMA films is shown by Fourier transform infrared spectroscopy, X‐ray photoelectron spectroscopy, fluorescence microscopy, and ellipsometry measurements to result in covalent coupling and identical grafting densities, as found previously for coupling from solution. The PEG‐protected areas effectively inhibit the adsorption of fluoresceinamine, bovine serum albumin, as well as 25‐mer DNA, while the unreacted N ‐hydroxysuccinimidyl methacrylate ester groups retain their reactivity towards primary amino groups. Biomolecule microarrays have been thus conveniently fabricated in a two‐step procedure. The hybridization of target DNA to immobilized probe DNA in micropatterns proves the concept of reactive μCP on activated polymer films for obtaining robust platforms for biomolecule immobilization and screening.
Automatic dominant camera motion annotation for video retrieval (1998)

An efficient method is derived to classify the dominant camera motions in video shots. Various 3-D camera motions including camera pan, tilt, zoom, Z-rotation, and translations are detected. The method is to analyze the optical flow in a decomposed manner. Images are divided into some sub-regions according to our camera model. The projected x and y components of optical flow are analyzed separately in the different sub-regions of the images. Different camera motions are recognized by comparing the computed result with the prior known patterns. The optical flow is computed by using the Lucas-Kanade method, which is quite efficient due to non- iteration computation. Our method is efficient and effective because only some mean values and standard deviations are used. The analysis and detailed description of our method is given in this paper. Experimental results are presented to show the effectiveness of our method.
<title>A Review Of Acousto-Optic Signal Correlators</title> (1976)

Many techniques have been proposed in the past for using acousto-optic devices to perform signal correlation. This paper reviews these techniques and discusses the design tradeoffs involved in choosing a particular configuration for a given application. Configurations are classed as two major types. The first type, spatial integrating correlators, perform correlation by integrating light diffracted by all parts of the signal(s) which are simulataneously present in the acoustic device. This type of correlator has a large range window, but the time bandwidth product is limited by device parameters. The second type, time integrating correlators, use a detector array to perform an integration in time for each point within the cell. This provides a limited range window but a large time bandwidth product. Results obtained with both types of systems are shown, along with pictures of fabricated hardware. Acousto-optic device parameters are also summarized for comparison with competitive technologies.
Assessing the Performance of Prediction Models (2009)

The performance of prediction models can be assessed using a variety of methods and metrics. Traditional measures for binary and survival outcomes include the Brier score to indicate overall model performance, the concordance (or c) statistic for discriminative ability (or area under the receiver operating characteristic [ROC] curve), and goodness-of-fit statistics for calibration.Several new measures have recently been proposed that can be seen as refinements of discrimination measures, including variants of the c statistic for survival, reclassification tables, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Moreover, decision-analytic measures have been proposed, including decision curves to plot the net benefit achieved by making decisions based on model predictions.We aimed to define the role of these relatively novel approaches in the evaluation of the performance of prediction models. For illustration, we present a case study of predicting the presence of residual tumor versus benign tissue in patients with testicular cancer (n = 544 for model development, n = 273 for external validation).We suggest that reporting discrimination and calibration will always be important for a prediction model. Decision-analytic measures should be reported if the predictive model is to be used for clinical decisions. Other measures of performance may be warranted in specific applications, such as reclassification metrics to gain insight into the value of adding a novel predictor to an established model.
Cell-penetrating peptides as delivery vehicles for biology and medicine (2008)

Cell-penetrating peptides (CPPs) have found numerous applications in biology and medicine since the first synthetic cell-permeable sequence was identified two decades ago. Numerous types of drugs have been transported into cells using CPPs, including small-molecule pharmaceuticals, therapeutic proteins, and antisense oligonucleotides. Improved agents for medical imaging have been generated by conjugation with CPPs, with the appended peptides promoting cellular uptake and in some cases, cell-type specificity. Organelle-specific CPPs have also been generated, providing a means to target specific subcellular sites. This review highlights achievements in this area and illustrates the numerous examples where peptide chemistry was exploited as a means to provide new tools for biology and medicine.
SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis (1988)

Necrotizing enterocolitis (NEC) was produced in anesthetized rabbits by transmural injection of intestinal loops with an acidified solution of casein and calcium gluconate, mimicking the luminal milieu of afflicted neonates. Intravenous infusion of superoxide dismutase (SOD) 15 min after NEC induction prevented intestinal damage. In ex vivo perfused intestinal loops, we determined the sites of eicosanoid release and their contribution to the vascular effects of N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) in damaged and SOD-salvaged intestine. The vascular effluent was the primary site of stimulated eicosanoid release. The vascular responses to fMLP (vasoconstriction) and PAF (vasodilation) were not altered by SOD, although vascular resistance was higher in the SOD group. SOD treatment attenuated 1) transmural fluid shifts in ex vivo perfused intestinal preparations, an index of vascular permeability, 2) fMLP-induced prostaglandin E2, 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha), and leukotriene B4 (LTB4) release, and 3) PAF-induced release of 6-keto-PGF1 alpha and LTB4. Stimulated thromboxane B2 release was not altered by SOD. Thus NEC can be established by a luminal insult that causes local generation of free radicals and exaggerated release of prostaglandins and leukotrienes.
Site-selective x-ray absorption fine structure: Selective observation of Ga local structure in DX center of Al0.33Ga0.67As:Se (1999)

In order to discuss the local structure of deep level carrier traps, the site-selective x-ray absorption fine structure (XAFS) by measuring the x-ray photon-energy dependence of the capacitance of a Schottky barrier diode is proposed. Dropping of the localized electron into a core hole arising from x-ray absorption of the atom in the carrier trap, not in bulk, increases the capacitance. The site-selective XAFS is adopted for the local structure analysis of DX center in Al0.33Ga0.67As:Se. The Ga K-edge site-selective XAFS is different from the conventional XAFS, suggesting that Ga in the DX center with a large lattice relaxation is selectively observed.
Biosafety steps in the manufacturing process of spray-dried plasma: a review with emphasis on the use of ultraviolet irradiation as a redundant biosafety procedure (2020)

Spray dried plasma (SDP) is a functional protein source obtained from blood of healthy animals, approved by the veterinary authorities from animals declared to be fit for slaughter for human consumption. Blood of these animals is collected at the slaughterhouse, treated with an anticoagulant, chilled and transported to industrial facilities in which blood is centrifuged to separate the red blood cells from the plasma fraction. Plasma is then concentrated, and spray dried at high temperatures (80 °C throughout its substance) to convert it in a powder. Such method preserves the biological activity of its proteins, mainly albumins and globulins. SDP is mainly used in pig feed diets to significantly improve daily gain, feed intake, production efficiency, and to reduce post-weaning lag caused by the appearance of post-weaning diarrhea. Although SDP is considered a safe product and its manufacturing process consists of several biosafety steps, the security of the SDP is often questioned due to its nature as raw blood by-product, especially when emergent or re-emergent pathogens appear. This review provides an evaluation and validation of the different safety steps present in the manufacturing process of SDP, with special focus on a new redundant pathogen inactivation step, the UV-C irradiation, that may be implemented in the manufacturing process of the SDP. Overall results showed that the manufacturing process of SDP is safe and the UV-C radiation was effective in inactivating a wide range of bacteria and viruses spiked and naturally present in commercially collected liquid animal plasma and it can be implemented as a redundant biosafety step in the manufacturing process of the SDP.
Enhancing and Sustaining Well Production: Granite Wash, Texas Panhandle (2007)

Abstract This paper will describe the ongoing Granite Wash completion project in the Buffalo Wallow field in Hemphill and Wheeler Counties, Texas. This study will discuss the reservoir development and characteristics, current and former completion techniques, and production comparisons. The goal for this study is to use best practices gained from a statistical analysis and new chemical technologies for completion procedures in the Granite Wash project utilizing a permeability core testing apparatus for optimized regained permeability in fracturing fluids. Surface modification agents (SMAs) and their coating onto proppant have been applied in treatments of thousands of wells in the last 10 years and have undeniably improved their productivity in terms of production rates and duration. The coating of these SMA materials has been found to dramatically enhance the recovery of aqueous-based fracturing fluids during well cleanup after fracturing treatments. As a result, a significant improvement in gas production has been observed in treated wells. Friction-reduction polymer anti-flocculants have been developed to reduce the tendency of these polymers to damage the proppant pack/reservoir interface, resulting in a decreased effective fracture length. A nonionic, micro-emulsion surfactant has been developed to reduce capillary pressure in producing hydraulic fractures via surface tension reduction and contact angle modification. These chemicals have been used in various combinations; the field results as well as testing results will be presented. A patented low-permeability core testing apparatus has tested two granite wash core samples from the Buffalo Wallow field for regained permeability using friction-reduction polymer anti-flocculants, SMAs (specifically diagenesis protective agents), and micro-emulsion surfactants. In addition, basic water-frac additive packages have been applied to continue the optimization of water fracs in the Texas Panhandle to increase long-term natural gas production. The data from those tests and field case histories will be discussed.
Photochemically Induced Gene Silencing Using PNA-Peptide Conjugates (2006)

The potential for exploration of peptide nucleic acid (PNA) as an experimental and therapeutic regulator of gene expression has been hampered by a poor delivery and a lack of site-specific targeting. In the present study, we have developed an efficient strategy for nuclear delivery of PNA by combining cationically charged PNA-peptide conjugates and photochemical internalization (PCI) technology. When using the S100A4 gene as a model system, a consistent downregulation to around 10% remaining protein signal was obtained in three selected cell lines. Furthermore, a dose-dependent and time-dependent inhibition of the S100A4 protein was demonstrated. A main benefit of the strategy proposed is the possibility of site-specific targeting.
Biomechanical Analysis of Pullout Strengths of Rotator Cuff and Glenoid Anchors: 2011 Update (2011)

Whereas larger fully threaded screw anchors designed for rotator cuff repair showed higher failure strengths than smaller non-screw anchors designed for glenoid repairs (P < .05), the larger version of a screw anchor for a cuff repair did not provide a statistically greater failure load than the smaller screw anchor.
De novo acute myeloid leukemia risk factors (2012)

The current results suggested that several factors play a role in AML predisposition with possible joint effects. Risk profiles for AML differed by sex and WHO subtype.