gebhart/patrepeval huggingface dataset:
A Porous Silicon−Palladium Composite Film for Optical Interferometric Sensing of Hydrogen (2005)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionNEXTORIGINAL ARTICLEThis notice is a correctionA Porous Silicon−Palladium Composite Film for Optical Interferometric Sensing of HydrogenHaohao Lin, Ting Gao, Joshua Fantini, and Michael J. SailorCite this: Langmuir 2005, 21, 4, 1661Publication Date (Web):January 21, 2005Publication History Published online21 January 2005Published inissue 1 February 2005https://pubs.acs.org/doi/10.1021/la058001yhttps://doi.org/10.1021/la058001ycorrectionACS PublicationsCopyright © 2005 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views307Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (21 KB) Get e-AlertscloseSUBJECTS:Coating materials,Hydrogen,Ions,Palladium,Redox reactions Get e-Alerts
Optimizing the Delivery of Cancer Drugs That Block Angiogenesis (2010)

Drugs that block angiogenesis are important components of first-line therapies for a number of human cancers. However, some of these agents have undesirable effects on the patient. Optimal delivery systems must be developed to maximize clinical benefits and minimize adverse effects in cancer patients. In this Perspective, we discuss these drug-related issues and propose ways to optimize antiangiogenic therapy by the development of new drug delivery systems.
Restoration of Antique (Sam-Sae Buddhistic Painting) In Song-Kwang Temple (1999)

The buddhistic painting of Song-Kwang temple in Seungjoo-gun, Chonnam, Korea is not known in chronicle, but it could be estimated to works in the early 19th century through it's remaining records and qualities of materials. And it was analysed the qualities of materials consisting of pigment layer, silken-ground layer and support layer in order to preserve buddhistic painting, made back-adherent paper of the support layer proper to it, tested its compatibility, and then concluded as follows. 1. The section structures of buddhistic painting is consisted of the pigment layer, silken-ground layer of silk and the support layer of Korean hand made paper, it could be recognized that buddhistic painting in 19th century was basically composed of the pigment layer, the silken-ground layer and the support layer. Moreover the pigment layer and the silken-ground layer got adhered with glue, and sheets of support layers got back adhered with paste. 2. The support layer of buddhistic painting consisted of 5 layers and two kinds of paper were used for them. The first and second layers were composed of Korean hand made paper made of pure paper mulberry bast fibers, and the rest of them of paper that paper mulberry bast fibers were mixed into recycled hemp fibers. Though it is difficult to assert without the security of more data, finding out the then situation through the qualities of materials, it was presumed that the society in 19th century was suffered from economical difficulties and the operation of the paper industry of temples was rather difficult and so low-qualitative recycled hemp fibers might used for back-adherent paper. 3. Considering tension between silken-ground layers and support layers of this materials, newly made back-adherent paper was used for repair, and then I could conform that it was proper to back-adherent paper for repair.
Al-Kindī: The Founder of Philosophical Exegesis of the Qur'an (2007)

Al-Kindī is well known as the first great ‘Islamic philosopher’. In contrast to his eminent successors, i.e. al-Fārābī, Ibn Sīnā and Ibn Rushd, he adhered to the idea of a creation in time, not to that of the eternity of the world. He appears to have made this choice out of religious motives: certainly he did find support in the philosophical arguments of Philoponus, but one is inclined to believe that he accepted this point of view because of what revelation tells on this issue. However, in those works of his that have reached us, one finds almost no references to the Qur'an. In his philosophical treatises there are, as far as I can see, explicit references to Qur'anic ayas in only three texts; the first two cases refer to Q. 36:78–82, and the third to Q. 6:55. In this article, an in-depth analysis of both fragments will be given and special attention will be paid to the – apparently outspoken, philosophical – interpretation that is given. Moreover, the extent to which al-Kindī designates or does not designate God in terms derived from the Qur'an will be examined. It is hoped that in this way al-Kindī's attitude towards the Qur'an can be determined with precision.
Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B Streptococcus. (1990)

The native capsular polysaccharide of type III group B Streptococcus elicits a specific antibody response in only 60% of nonimmune human subjects. To enhance the immunogenicity of this polysaccharide, we coupled the type III polysaccharide to tetanus toxoid. Prior to coupling, aldehyde groups were introduced on the polysaccharide by controlled periodate oxidation, resulting in the conversion of 25% of the sialic acid residues of the polysaccharide to residues of the 8-carbon analogue of sialic acid, 5-acetamido-3,5-dideoxy-D-galactosyloctulosonic acid. Tetanus toxoid was conjugated to the polysaccharide by reductive amination, via the free aldehyde groups present on the partially oxidized sialic acid residues. Rabbits vaccinated with the conjugate vaccine produced IgG antibodies that reacted with the native type III group B streptococcal polysaccharide (3/3 rabbits), while rabbits immunized with the unconjugated type III polysaccharide failed to respond (0/3 rabbits). Sera from animals receiving conjugate vaccine opsonized type III group B streptococci for phagocytic killing by human peripheral blood leukocytes, and protected mice against lethal challenge with live type III group B streptococci. The results suggest that this method of conjugation to a carrier protein may be a useful strategy to improve the immunogenicity of the type III group B Streptococcus polysaccharide in human subjects.
KSb5S8: A Wide Bandgap Phase‐Change Material for Ultra High Density Rewritable Information Storage (2003)

A well defined, congruently melting stoichiometric system , KSb 5 S 8 (see Figure), with a wide optical energy gap that undergoes rapid reversible crystal–glass transformation is described. The activation energy of crystallization E c was calculated to be ∼ 167 kJ mol –1 . The kinetic parameters and energy bandgaps of KSb 5 S 8 suggest a new inexpensive phase‐change material for possible ultra high density data storage applications.
Limits on neutron emission from ‘‘cold fusion’’ in metal hydrides (1990)

We have investigated possible neutron emission from cells containing titanium and palladium under ${\mathrm{D}}_{2}$, DT, or HD gas at pressures near 10 and 50 atm and at temperatures between -197 \ifmmode^\circ\else\textdegree\fi{}C and room temperature. Spurious backgrounds were eliminated from the data by means of coincidence counting, and through analysis of the energy and temporal distribution of the detected pulses. After 1500 hours of observation, we have seen no evidence for either steady-state neutron production or short (100 \ensuremath{\mu}s) neutron bursts. The limits we obtain, scaled for sample size, are in conflict with all present reports of neutron emission in metal hydrides under high gas pressure and thermal stress.
Effects of immunization against human choriogonadotropin on the growth of transplanted Lewis lung carcinoma and spontaneous mammary adenocarcinoma in mice. (1987)

We studied the effects of preimmunization with a synthetic carboxy-terminal peptide of the beta-subunit of human choriogonadotropin (hCG) conjugated to diphtheria toxoid on the growth of two tumor models, the transplantable Lewis lung carcinoma in C57BL/6J mice and the spontaneous mammary carcinoma in C3H/OuJ mice. Immunization with the conjugate prior to Lewis lung tumor implantation significantly (P less than 0.05) retarded the growth of tumors as measured by tumor weight 18 days following transplantation. The weights of Lewis lung tumors in animals preimmunized with the hCG immunogen were inversely correlated (r = 0.61) with the levels of circulating antibodies against human chorionic gonadotropin, whereas no statistical correlation was found between tumor weights and the levels of antibodies reactive to diphtheria toxoid. The number of conjugate-treated C3H/OuJ mice that developed mammary tumors was significantly (P less than 0.05) reduced compared to their vehicle-treated cohorts. Pretreatment with the synthetic muramyl dipeptide analog utilized as an adjuvant with both immunogens did not show any effect on the tumor growth in either tumor system.
Structure of the human cyclo-oxygenase-2 gene (1994)

Cyclo-oxygenase (Cox), a rate-limiting enzyme in the synthesis of prostanoids, is encoded by two genes, Cox-1 and Cox-2, which are differentially expressed and regulated. Human Cox-1 and -2 polypeptides share 61% primary sequence identity. While the expression of Cox-1 is maximal in quiescent cells. Cox-2 expression is induced by growth factors and cytokines. We have screened a human genomic library with a probe from the 5'-untranslated region (UTR) of the human Cox-2 (hCox-2) cDNA and isolated two overlapping genomic clones. We have determined the DNA sequence of 0.8 kb upstream of the transcription start site, 6 kb of protein coding region, which includes 10 exons and 9 introns, as well as 2.5 kb of the 3'-UTR. The structures of the hCox-1 and hCox-2 and the murine TIS10 (Cox-2) genes are highly conserved, with a few exceptions. The 3'-UTRs of the Cox-1 and -2 genes are distinct; for example, the largest exon in the Cox-2 gene encodes the entire 3'-UTR, containing 22 copies of the 'AUUUA' RNA instability element. Sequence analysis of the 5'-flanking region has shown several potential transcription regulatory sequences, including a TATA box, a C/EBP motif, two AP-2 sites, three SP1 sites, two NF-kappa B sites, a CRE motif and an Ets-1 site. These efforts serve as a basis for future studies on transcriptional and post-transcriptional mechanisms of Cox-2 gene regulation.
Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes (2009)

Lentiviral vectors containing promoters of distinct origins, that is, strong viral promoters (cytomegalovirus [CMV] and murine stem cell virus [MSCV]), a cellular promoter (phosphoglycerate kinase [PGK]), and two composite promoters (CAG [a composite promoter sequence comprised of the CMV enhancer and portions of the chicken beta-actin promoter and the rabbit beta-globin gene] and SV40/CD43), were used to evaluate green fluorescent protein (GFP) reporter gene expression in human primary peripheral blood lymphocytes (PBLs) and tumor-infiltrating lymphocytes (TILs). In PBLs, vectors containing the MSCV promoter were found to be optimal for expression in both minimally stimulated and highly activated lymphocytes. The stability of gene expression was monitored for up to 7 weeks in culture and the MSCV promoter-containing vector was found to be comparable to the cellular PGK promoter-containing vector. The MSCV promoter-containing lentiviral vector was also the most active in transduced TILs and these cells retained biological activity as measured by antimelanoma antigen reactivity. Using the knowledge gained in comparing individual promoters, a series of two-gene-containing lentiviral vectors was constructed in an attempt to produce the alpha and beta chains of antitumor antigen T cell receptors (TCRs). Dual-promoter or internal ribosome entry site (IRES)-containing vector designs were evaluated and found to be unable to produce both chains of the TCR in amounts that led to significant biological activity. In contrast, if the alpha and beta chains were linked by a 2A ribosomal skip peptide, both proper TCR chain pairing and biologically activity were observed. This paper emphasizes the need to optimize both promoter function and protein synthesis in constructs that require stoichiometric production of multiple protein subunits.
Response of Single Alpha Motoneurons to High-Frequency Pulse Trains (1986)

Studies were conducted on 25 cats to document the discharge rates of alpha motoneurons during stimulation of the sciatic nerve at frequencies from 100 to 10,000 pulses per second (pps). In addition, the feasibility of using high-frequency pulse trains to block the conduction of action potentials was investigated. Two cuff electrodes were placed around the proximal portion of the left sciatic nerve, and recordings of antidromic potentials were taken from single fibers of the L7 ventral root. When stimulating through the more proximal electrode, discharge rates were generally equal to or were subharmonics of the stimulation rate up to 1,000 pps. Firing often decreased in rate during 3-min runs. At 2,000-10,000 pps, fibers responded briefly at rates of several hundred per second but stopped firing within seconds after stimulus initiation. After cessation of response to the high-frequency pulse train, action potentials generated at 50 pps at the more distal electrode did not propagate to the recording electrodes. The 'electrical block' so induced was maintained for up to 20 min, and recovery following termination of the pulse train was complete within 1 s.
Internalizing Antibodies to the C-Type Lectins, L-SIGN and DC-SIGN, Inhibit Viral Glycoprotein Binding and Deliver Antigen to Human Dendritic Cells for the Induction of T Cell Responses (2006)

The C-type lectin L-SIGN is expressed on liver and lymph node endothelial cells, where it serves as a receptor for a variety of carbohydrate ligands, including ICAM-3, Ebola, and HIV. To consider targeting liver/lymph node-specific ICAM-3-grabbing nonintegrin (L-SIGN) for therapeutic purposes in autoimmunity and infectious disease, we isolated and characterized Fabs that bind strongly to L-SIGN, but to a lesser degree or not at all to dendritic cell-specific ICAM-grabbing nonintegrin (DC-SIGN). Six Fabs with distinct relative affinities and epitope specificities were characterized. The Fabs and those selected for conversion to IgG were tested for their ability to block ligand (HIV gp120, Ebola gp, and ICAM-3) binding. Receptor internalization upon Fab binding was evaluated on primary human liver sinusoidal endothelial cells by flow cytometry and confirmed by confocal microscopy. Although all six Fabs internalized, three Fabs that showed the most complete blocking of HIVgp120 and ICAM-3 binding to L-SIGN also internalized most efficiently. Differences among the Fab panel in the ability to efficiently block Ebola gp compared with HIVgp120 suggested distinct binding sites. As a first step to consider the potential of these Abs for Ab-mediated Ag delivery, we evaluated specific peptide delivery to human dendritic cells. A durable human T cell response was induced when a tetanus toxide epitope embedded into a L-SIGN/DC-SIGN-cross-reactive Ab was targeted to dendritic cells. We believe that the isolated Abs may be useful for selective delivery of Ags to DC-SIGN- or L-SIGN-bearing APCs for the modulation of immune responses and for blocking viral infections.
High-dose cholecalciferol to correct vitamin D deficiency in haemodialysis patients (2008)

Vitamin D deficiency is present in a majority of haemodialysis patients. Supplementation with cholecalciferol is safe, well tolerated and reasonable to replenish vitamin D stores in haemodialysis patients. However, only 57% of patients achieved recommended calcidiol levels, thus favouring additional dose-finding studies.
Stereospecificity and stereochemical infidelity of acetoacetate decarboxylase (AAD) (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecificity and stereochemical infidelity of acetoacetate decarboxylase (AAD)Steven A. Benner, J. David Rozzell Jr., and Thomas Hellman MortonCite this: J. Am. Chem. Soc. 1981, 103, 4, 993–994Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://doi.org/10.1021/ja00394a071RIGHTS & PERMISSIONSArticle Views172Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (313 KB) Get e-Alerts Get e-Alerts
Polymer micro-ring filters and modulators (2002)

Micro-ring wavelength filters and resonant modulators using polymer materials at 1300 nm and 1550 nm are analyzed, designed, and demonstrated. The rings are integrated with vertically coupled input and output waveguides. The devices are fabricated using optical lithography. Filters with a finesse of 141 and free spectral range of 5 nm at 1300 nm and finesse of 117 with a free spectral range (FSR) of 8 nm at 1550 nm are demonstrated. Ring resonators with a Q as high as 1.3 /spl times/ 10/sup 5/ at 1300 nm are demonstrated. The filters can be temperature tuned at the rate of 14 GHz//spl deg/C. Resonant ring modulators, which use an electrooptic polymer, are demonstrated. The resonance wavelength voltage tunes at the rate of 0.82 GHz/V. The modulators have a bandwidth larger than 2 GHz. Using the resonant modulator, and open eye diagram at 1 Gb/s is demonstrated.
Synthesis and Reactivity of 5-Fluorouracil/Cytarabine Mutual Prodrugs (1997)

Two mutual prodrugs, in which two different anti-cancer drugs are attached to the same molecule via labile linkages, are synthesized and examined kinetically. One of the mutual prodrugs loses a drug component under physiological conditions within an hour, but the other mutual prodrug (having a longer spacer between the two drugs) is stable to chemical degradation even at higher pH values. Thus, enzymatic hydrolysis alone will release the two anti-cancer drugs. The potential value of anti-cancer mutual prodrugs is discussed.
Site‐selective versus promiscuous A‐to‐I editing (2011)

RNA editing by adenosine deamination is acting on polymerase II derived transcripts in all metazoans. Adenosine-to-inosine (A-to-I) editing is mediated by the adenosine deaminase that acts on RNA (ADAR) enzymes. Two types of adenosine to inosine (A-to-I) RNA editing have been defined: site selective and hyper-editing. Typically, in site selectively edited substrates, one or a few A-to-I sites are edited in double-stranded RNA structures, frequently interrupted by single-stranded bulges and loops. Hyper-editing occurs in long stretches of duplex RNA where multiple adenosines are subjected to deamination. In this review, recent findings on editing within noncoding RNA as well as examples of site selective editing within coding regions are presented. We discuss how these two editing events have evolved and the structural differences between a site selective and hyper-edited substrate.
Tołpa Torf Preparation (TTP) induces interferon and tumor necrosis factor production in human peripheral blood leukocytes. (1993)

Tołpa Torf Preparation (TTP) is a natural immunomodulating drug registered in Poland for use in humans. TTP is a biologically active low molecular weight fraction of an extract from peat containing organic substances, primary bound sugars, amino-acids, uronic and huminic acids and mineral salts. The toxicity of TTP is remarkably low, eg. cytotoxicity (CD50) for human peripheral blood leukocytes (PBL) is 1-9 mg/ml. We have discovered that TTP is an interferon (IFN) and tumor necrosis factor (TNF) inducer in human PBL. The IFN and TNF response of the PBL cultures was dose dependent. The optimal concentration of TTP for IFN or TNF response was 10-100 micrograms/ml. The cytokines stimulated by TTP were IFN-gamma, IFN-alpha and TNF-alpha. Ten commercial batches of TTP have been found to be active as cytokines inducers although variations in their activities were observed. On the other hand, 8 batches of TTP rejected by the producer because of the inadequate immunostimulating activity determined in mice, were found to be significantly less active than the commercial preparations. Over 115 buffy coats from the individual blood donors were used to prepare PBL cultures for this study. Approximately 20% of the PBL cultures were unresponsive to TTP. The IFN and TNF response of PBL to other inducers: phytohemagglutinin (PHA) or lipopolysaccharides (LPS) also varied. Whereas only 7% of PBL could not be stimulated by PHA, as much as 20-50% of PBL failed to produce IFN or TNF when treated with LPS. We suggest that TTP may have clinically useful activities connected with the capacity of stimulation of IFNs and TNF production.
Photolysis of (arylmethyl)triphenylphosphonium salts. Substituent, counterion, and solvent effects on reaction products (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotolysis of (arylmethyl)triphenylphosphonium salts. Substituent, counterion, and solvent effects on reaction productsC. Imrie, T. A. Modro, E. R. Rohwer, and C. C. P. WagenerCite this: J. Org. Chem. 1993, 58, 21, 5643–5649Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jo00073a023https://doi.org/10.1021/jo00073a023research-articleACS PublicationsRequest reuse permissionsArticle Views1624Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts