gebhart/patrepeval huggingface dataset:
6 DoF SLAM using a ToF camera: The challenge of a continuously growing number of landmarks (2010)

Localization and mapping are fundamental problems in service robotics since representations of the environment and knowledge about the own pose significantly simplify the implementation of a series of high-level applications. ToF (time-of-flight) cameras are a relatively new kind of sensors in robotics. They enable the real-time capture of the distance and the grayscale information of a scene. Due to the increase of the image resolution of ToF cameras, now highlevel computer vision algorithms for visual feature extraction (e.g. SIFT or SURF) can be applied to the captured images. These visual features combined with the corresponding distance information give a full measurement of 3D landmarks. An obvious problem to be solved is the continuously growing number of landmarks. So far, all ever seen landmarks are just accumulated irrespective of their utility and the then required resources. Rather, one should keep only really useful landmarks, e.g. such that localization quality in the whole operational area is kept above a given threshold. In fact a lifelong running SLAM approach is dependent on means to select and discard landmarks. That is even more acute in case of feature-rich sensor data as provided with high update rates by sensors like a ToF camera. We run our SLAM approach in a real-world experiment within an indoor environment. The experiment was performed on a P3DX-platform equipped with a PMD CamCube 2.0 and a Xsens IMU.
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. (1988)

Human alpha- and beta-interferons (IFNs) stimulate rapid but transient increases in transcription from a set of previously quiescent genes. Protein synthesis is not required for initial stimulation, but duration of the response is limited to a few hours by a process requiring synthesis of new proteins. An IFN-stimulated response element (ISRE) was identified 5' to an inducible gene by deletion analysis and point mutagenesis, and sequence comparisons with other promoters defined the consensus element YAGTTTC(A/T)YTTTYCC. Two classes of IFN-inducible nuclear factors were found that bind to the ISRE. The most rapidly induced factor appeared without new protein synthesis, whereas a second factor required active protein synthesis for its appearance and maintenance. The kinetics of appearance and loss of these binding activities correlate with the activation and repression of IFN-stimulated genes. These different IFN-activated or induced factors may bind sequentially to the same essential promoter element to first increase and then repress transcription.
The Virtual Learning Environment system (2002)

The Virtual Learning Environment (VLE) is an integrated university environment where students can apply for admission over the internet, enroll in the classes offered by VLE after admission, access a complete course, take tests, and interact with the professors as well as classmates. The VLE has tools for administrators, professors and students for performing their duties. VLE supports the goals of a virtual university. The VLE implements specific modules for routine administrative functions of a university environment. VLE provides for student admission, course registration, grade management, and administrative report generation among other functions. It implements all the functions for a student to take the course over the VLE. The VLE allows students to view lectures and access the study material for every topic of the course. The students are given tests at specified times, and answers to the questions are transmitted to the professor automatically. The communication hub of the VLE has an e-mail facility, chat facility, and a multimedia teleconferencing system. In addition, it has all the tools and instructions for a professor to develop the material for a course to be offered through the VLE. It also includes all the day-to-day procedures that a professor must follow once the course is ready for delivery to the students.
Superagonistic CD28 Antibody Induces Donor-Specific Tolerance in Rat Renal Allografts (2008)

The ultimate goal of organ transplantation is to establish graft tolerance where CD4+CD25+FOXP3+ regulatory T (Treg) cells play an important role. We examined whether a superagonistic monoclonal antibody specific for CD28 (CD28 SA), which expands Treg cells in vivo, would prevent acute rejection and induce tolerance using our established rat acute renal allograft model (Wistar to Lewis). In the untreated or mouse IgG-treated recipients, graft function significantly deteriorated with marked destruction of renal tissue, and all rats died by 13 days with severe azotemia. In contrast, 90% of recipients treated with CD28 SA survived over 100 days, and 70% survived with well-preserved graft function until graft recovery at 180 days. Analysis by flow cytometry and immunohistochemistry demonstrated that CD28 SA induced marked infiltration of FOXP3+ Treg cells into the allografts. Furthermore, these long-surviving recipients showed donor-specific tolerance, accepting secondary (donor-matched) Wistar cardiac allografts, but acutely rejecting third-party BN allografts. We further demonstrated that adoptive transfer of CD4+CD25+ Treg cells, purified from CD28 SA-treated Lewis rats, significantly prolonged allograft survival and succeeded in inducing donor-specific tolerance. In conclusion, CD28 SA treatment successfully induces donor-specific tolerance with the involvement of Treg cells, and thus the therapeutic value of this approach warrants further investigation and preclinical studies.
Abstract 1466: Regulation of colon cancer metastasis by sprouty-2 (2014)

Abstract Introduction: We earlier established that sprouty-2 is overexpressed in human colon cancer and up-regulates c-met and thereby increases the growth phenotype and metastatic potential of colon cancer cells (Oncogene, 29: 5241-53, 2010). To our knowledge, this was the first study to demonstrate the tumor oncogene phenotype of sprouty-2 in colon cancer metastasis. On the contrary, cancer protective role of sprouty-2 was noted in breast, liver and prostate cancers. However, a recent report on non-small cell lung cancer (NSCLC) discovered that silencing of sprouty-2 reduced c-met expression and thus confirmed our findings in colorectal cancer (PNAS, 110: 8573-78, 2013). We further extended our studies to demonstrate that this pathway modulates gastrointestinal specific microRNAs (miRNAs) and regulates various oncogenes and tumor suppressor genes in colon cancer cells. Methods: RNA from control and shRNA sprouty-2 transfected cells were labeled with Hy5 and Hy3 respectively and hybridized to miRCURY LNA arrays. Unsupervised miRNA clustering was carried out and a heat map prepared with Java TreeView. MicroRNA targets were identified by Real-time PCR, western blotting and 3′UTR luciferase assays. Migratory phenotype of colon cancer cells was confirmed by cell migration and invasion assays in trans-well chambers. Cancer cells were transfected by miRNA mimics to assess the expression levels of target genes. Human colon cancer tissue microarrays were utilized to assess the expression of miRNA target genes. Human tumor sections were evaluated by immunofluorescence and immunohistochemical staining. Results: Sprouty-2 shRNA transfected stable cell lines demonstrated upregulation of tumor suppressive miRNAs and down-regulation of oncogenic miRNAs. Overexpression of gastrointestinal specific miRNA mimics inhibits colon cancer cells proliferation and metastasis. On the contrary, overexpression of miRNA inhibitor in colon cancer cells promotes proliferation and colonization. Studies further indicated that miRNA down-regulates expression of CDK7, RB1, AKT, FASL, IGF1R, EGFR and N-cadherin and up-regulates expression of P21 and E-cadherin. MiRNA regulated genes were responsible for cell cycle arrest, enhanced apoptosis and decreased metastasis. AKT was upregulated whereas E-cadherin was downregulated at the invasive fronts in human colon tumors. Conclusion: Sprouty-2/miRNA expression levels could be used to risk-stratify patients for CRC recurrence and sprouty-2 axis regulation may lead to the development of therapeutics in colon and lung cancer. Citation Format: Qiong Zhang, Vivek Vaish, Sharad Khare. Regulation of colon cancer metastasis by sprouty-2. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1466. doi:10.1158/1538-7445.AM2014-1466
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance (2001)

There is accumulating evidence that T-cell-mediated dominant control of self-reactive T-cells contributes to the maintenance of immunologic self-tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T-cell population have revealed that CD25+ cells in the CD4+ population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro. The CD25+ CD4+ regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.
A 1.8-GHz CMOS Power Amplifier Using Stacked nMOS and pMOS Structures for High-Voltage Operation (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <?Pub Dtl=""?>A class-E power amplifier is proposed in this study. It uses both nMOS and pMOS as switching devices to reduce the voltage stress of each transistor. A voltage-combining scheme with nMOS and pMOS is proposed, and a transformer is designed using this scheme. The power amplifier is implemented in a 0.18-<formula formulatype="inline"><tex Notation="TeX">$\mu{\hbox{m}}$</tex> </formula> RF CMOS process. Measurements show a maximum output power of 30.2 dBm with 36.8% power-added efficiency at a 3.3-V supply voltage. The power amplifier sustains a supply voltage of up to 3.9 V. </para>
Heavy-Chain-Only Antibody Expression and B-Cell Development in the Mouse (2006)

Antibodies expressed in mice, humans, and most mammals consist of paired heavy (H) and light (L) chains. Cellular release of single H-chains without L-chains is prevented by chaperone association and retention in the endoplasmic reticulum. Consequently, H-chain-only antibodies are absent, except in pathological conditions known as Heavy Chain Disease, where they occur in mutated form. An exception to this is found in the serum of Camelidae. Homodimeric H-chain antibodies in camelids lack the first constant region domain (CH1) of the H-chain but retain an otherwise intact H-chain polypeptide, thus maintaining antigen specificity and effector functions. In this review, we summarize how H-chain antibodies can be expressed in mice, and whether normal developmental processes leading to antibody expression without L-chain are retained.
Speech Synthesis and Recognition (2002)

With the growing impact of information technology on daily life, speech is becoming increasingly important for providing a natural means of communication between humans and machines. This extensively reworked and updated new edition of Speech Synthesis and Recognition is an easy-to-read introduction to current speech technology. Aimed at advanced undergraduates and graduates in electronic engineering, computer science and information technology, the book is also relevant to professional engineers who need to understand enough about speech technology to be able to apply it successfully and to work effectively with speech experts. No advanced mathematical ability is required and no specialist prior knowledge of phonetics or of the properties of speech signals is assumed.
An Osteoprotegerin-like Peptidomimetic Inhibits Osteoclastic Bone Resorption and Osteolytic Bone Disease in Myeloma (2007)

Multiple myeloma is a B-cell malignancy characterized by the uncontrolled growth of plasma cells in the bone marrow and the development of osteolytic bone disease. Myeloma cells express the receptor activator of nuclear factor kappaB ligand (RANKL), induce RANKL expression in the bone marrow, and down-regulate expression of the decoy receptor osteoprotegerin, thereby promoting bone resorption. Targeting this system in myeloma has clear therapeutic potential. However, osteoprotegerin also binds tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and prevents TRAIL-induced apoptosis of myeloma cells. Whether or not osteoprotegerin can bind TRAIL and prevent apoptosis in vivo and the relative importance of osteoprotegerin binding to TRAIL and RANKL are unclear. In the present study, we have investigated the ability of an osteoprotegerin-like peptidomimetic (OP3-4), designed to block the RANKL/RANK interaction, to inhibit osteoclastic bone resorption and TRAIL-induced apoptosis in vitro and myeloma bone disease in vivo. OP3-4 inhibited osteoclast formation (P < 0.01) and bone resorption (P < 0.01) in vitro. However, OP3-4 had no effect on TRAIL-induced apoptosis of RPMI 8226 myeloma cells. Treatment of 5T2MM myeloma-bearing mice with OP3-4 decreased osteoclast number and the proportion of bone surface covered by osteoclasts (P < 0.05). Treatment also prevented the tumor-induced decrease in cancellous bone area and the development of osteolytic lesions (P < 0.05). OP3-4 also reduced tumor burden when compared with the control (P < 0.05). These data suggest that OP3-4 and the selective inhibition of RANKL, but not TRAIL activity, are effective in preventing myeloma bone disease and offer a novel therapeutic approach to treating this aspect of myeloma. [Cancer Res 2007;67(1):202-8].
White-light-emitting organic electroluminescent devices based on interlayer sequential energy transfer (1999)

We demonstrate efficient, molecular organic white-light-emitting devices using vacuum-deposited thin films of red luminescent [2-methyl-6-[2-(2,3,6,7-tetrahydro-1H, 5H-benzo [ij] quinolizin-9-yl) ethenyl]-4H-pyran-4-ylidene] propane-dinitrile (DCM2), doped into blue-emitting 4, 4′ bis [N-1-napthyl-N-phenyl-amino]biphenyl (α-NPD), and green-emitting tris-(8-hydroxyquinolinato) aluminum(III) (AlQ3). The luminescent layers are separated by a hole-blocking layer of 2,9-dimethyl, 4,7-diphenyl, 1,10-phenanthroline (BCP), whose thickness is on the order of a typical Förster transfer radius of 30–40 Å. Excitons formed on α-NPD sequentially transfer their energy via a Förster mechanism to AlQ3 across the BCP layer, and from AlQ3 to DCM2. This interlayer sequential energy transfer results in partial excitation of all three molecular species, thereby producing white light emission. The thickness of the blocking layer and the concentration of DCM2 in α-NPD permit the tuning of the device spectrum to achieve a balanced white emission with Commission Internationale d’Eclairage chromaticity coordinates of (0.33, 0.33). The spectrum is largely insensitive to the drive current, and the devices have a maximum luminance of 13 500 cd/m2. At a luminance of 100 cd/m2, the quantum and power efficiencies are 0.5% and 0.35 lm/W, respectively.
Virus Maturation by Budding (1998)

Enveloped viruses mature by budding at cellular membranes. It has been generally thought that this process is driven by interactions between the viral transmembrane proteins and the internal virion components (core, capsid, or nucleocapsid). This model was particularly applicable to alphaviruses, which require both spike proteins and a nucleocapsid for budding. However, genetic studies have clearly shown that the retrovirus core protein, i.e., the Gag protein, is able to form enveloped particles by itself. Also, budding of negative-strand RNA viruses (rhabdoviruses, orthomyxoviruses, and paramyxoviruses) seems to be accomplished mainly by internal components, most probably the matrix protein, since the spike proteins are not absolutely required for budding of these viruses either. In contrast, budding of coronavirus particles can occur in the absence of the nucleocapsid and appears to require two membrane proteins only. Biochemical and structural data suggest that the proteins, which play a key role in budding, drive this process by forming a three-dimensional (cage-like) protein lattice at the surface of or within the membrane. Similarly, recent electron microscopic studies revealed that the alphavirus spike proteins are also engaged in extensive lateral interactions, forming a dense protein shell at the outer surface of the viral envelope. On the basis of these data, we propose that the budding of enveloped viruses in general is governed by lateral interactions between peripheral or integral membrane proteins. This new concept also provides answers to the question of how viral and cellular membrane proteins are sorted during budding. In addition, it has implications for the mechanism by which the virion is uncoated during virus entry.
The expression of native and cultured RPE grown on different matrices (2004)

The purpose of this work was to determine the expression profiles of retinal pigment epithelial (RPE) cells grown on different matrices and to assess the degree of culture-induced artifact by comparing the profiles to native RPE. Visually confluent ARPE-19 cells were grown on plastic, Matrigel, collagen I, collagen IV, laminin, and fibronectin for 1 wk, and serum was withdrawn for 3 days. Morphologically normal, macular RPE cells were laser-capture microdissected from three human eye globes. Total RNA was extracted from 5,000 cells and reverse transcribed, and radiolabeled cDNA probes were hybridized to an array containing 4,325 known genes. Arrays were assessed by cluster analysis and significance analysis of microarrays (SAM). Real-time RT-PCR was used to validate differentially expressed genes. Despite similar morphology, ARPE-19 demonstrated different expression profiles when grown on different matrices. Cluster analysis showed that cells grown on collagen IV, laminin, and fibronectin had similar profiles that were distinct from cells grown on collagen I. Cells grown on plastic clustered closest to native RPE. This expression pattern was confirmed with supervised cluster analyses. The number of differentially expressed genes, function of differentially expressed genes, and profile of expressed and unexpressed genes suggest that the overall expression profile of cultured cells is significantly different from native RPE. RPE cells grown on collagen IV, laminin, and fibronectin have profiles more similar than cells grown on plastic, Matrigel, or collagen I. The overall mRNA phenotype, however, is different from morphologically normal, native macular RPE.
Can islet cell transplantation treat diabetes? (2000)

Type 1 diabetes mellitus is a major burden on patients and healthcare economies. The early identification of patients at risk of developing chronic complications would allow timely intervention thus reducing complications, improving the quality of life, prolonging life expectancy, and lowering the cost of treatment. The main determinant of developing chronic complications is prolonged exposure to hyperglycaemia.1 There is no doubt that intensive insulin regimens can reduce the onset and progression of complications from diabetes but they are non-physiological and have an increased risk of causing severe hypoglycaemia. They are also labour intensive and difficult for patients to implement.

The only way to restore long term euglycaemia is by transplanting a vascularised pancreas. This procedure has been performed in over 15 000 recipients worldwide and has an 85% rate of graft survival at one year— that is, these recipients remained insulin independent.2 During the past …
La esclavitud voluntaria (2014)

The permissibility of actions depends upon facts about the flourishing and separateness of persons. Persons differ from other creatures in having the task of discovering for themselves, by conjecture and refutation, what sort of life will fulfil them. Compulsory slavery impermissibly prevents some persons from pursuing this task. However, many people may conjecture that they are natural slaves. Some of these conjectures may turn out to be correct. In consequence, voluntary slavery, in which one person welcomes the duty to fulfil all the commands of another, is permissible. Life-long voluntary slavery contracts are impermissible because of human fallibility; but fixed-term slavery contracts should be legally enforceable. Each person has the temporarily alienable moral right to direct her own life.
Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis (2007)

Tau in Alzheimer disease brain is highly phosphorylated and aggregated into paired helical filaments comprising characteristic neurofibrillary tangles. Here we have analyzed insoluble Tau (PHF-tau) extracted from Alzheimer brain by mass spectrometry and identified 11 novel phosphorylation sites, 10 of which were assigned unambiguously to specific amino acid residues. This brings the number of directly identified sites in PHF-tau to 39, with an additional six sites indicated by reactivity with phosphospecific antibodies to Tau. We also identified five new phosphorylation sites in soluble Tau from control adult human brain, bringing the total number of reported sites to nine. To assess which kinases might be responsible for Tau phosphorylation, we used mass spectrometry to determine which sites were phosphorylated in vitro by several kinases. Casein kinase 1delta and glycogen synthase kinase-3beta were each found to phosphorylate numerous sites, and each kinase phosphorylated at least 15 sites that are also phosphorylated in PHF-tau from Alzheimer brain. A combination of casein kinase 1delta and glycogen synthase kinase-3beta activities could account for over three-quarters of the serine/threonine phosphorylation sites identified in PHF-tau, indicating that casein kinase 1delta may have a role, together with glycogen synthase kinase-3beta, in the pathogenesis of Alzheimer disease.
Molecular Imaging in Cancer (2006)

Medical imaging technologies have undergone explosive growth over the past few decades and now play a central role in clinical oncology. But the truly transformative power of imaging in the clinical management of cancer patients lies ahead. Today, imaging is at a crossroads, with molecularly targeted imaging agents expected to broadly expand the capabilities of conventional anatomical imaging methods. Molecular imaging will allow clinicians to not only see where a tumor is located in the body, but also to visualize the expression and activity of specific molecules (e.g., proteases and protein kinases) and biological processes (e.g., apoptosis, angiogenesis, and metastasis) that influence tumor behavior and/or response to therapy. This information is expected to have a major impact on cancer detection, individualized treatment, and drug development, as well as our understanding of how cancer arises.
Eucalyptol suppresses matrix metalloproteinase-9 expression through an extracellular signal-regulated kinase-dependent nuclear factor-kappa B pathway to exert anti-inflammatory effects in an acute lung inflammation model (2015)

Thus, eucalyptol may be a potentially important agent in the treatment of pulmonary inflammation.