gebhart/patrepeval huggingface dataset:
A novel biocompatible adhesive incorporating plant‐derived monomers (2008)

We describe a new class of biomaterials with potential for a variety of applications in tissue engineering, wound healing, and transdermal drug delivery. These materials are based on oleic methyl ester (OME), which is derived from various plant oils including soybean oil. The OME was acrylated (AOME) and subsequently copolymerized with methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) to form pressure sensitive adhesives (PSAs). We assessed the cytocompatibility of each PSA product using Alamar Blue and Live/Dead assays. It was found that after 2 h, human fibroblast cells attached on all four of the PSA polymers tested. After 24 h, cell spreading was seen on all materials with the exception of the polymerized AOME product (PAOME). Cells attached to the copolymer PSA products continued to proliferate for up to 2 weeks, as shown by fluorescent confocal microscopy imaging. Finally, a mechanical analysis of each of the copolymers is presented demonstrating that they have a range of mechanical properties and cell adhesiveness depending on the formulation, making them attractive candidates for use as bioactive adhesives.
Scale-space and edge detection using anisotropic diffusion (1990)

A new definition of scale-space is suggested, and a class of algorithms used to realize a diffusion process is introduced. The diffusion coefficient is chosen to vary spatially in such a way as to encourage intraregion smoothing rather than interregion smoothing. It is shown that the 'no new maxima should be generated at coarse scales' property of conventional scale space is preserved. As the region boundaries in the approach remain sharp, a high-quality edge detector which successfully exploits global information is obtained. Experimental results are shown on a number of images. Parallel hardware implementations are made feasible because the algorithm involves elementary, local operations replicated over the image.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nuclear Fusion of Protons with Boron (1992)

One of the most interesting fusion reaction is a proton colliding with an ion of Boron 11. Two methods are investigated in this paper to convert the released fusion energy directly in electric power. The first is very simply the use of a beam of protons transversing a fixed target of Boron. Unfortunately this method cannot be made to work but its investigation naturally yields to the second method which makes use of two beams, one of protons and one of ions of Boron, colliding with each other.
An embedded stereovision system: Aspects of measurement precision (2010)

Computational performance of embedded systems heavily increased during last decade and tasks, which used to have a real time solution only in PC based vision systems are being ported to stand alone devices. One of the typical demanding vision tasks is 3D vision. This work describes design of a simple embedded stereo vision sensor - smart camera that can be used for spatial measurement. The system consists of a single core DSP processor and can work in several different setups because of its modular conception. The camera performs all computations itself and it is able to transmit the measurement results to a master unit using various interfaces including USB 2.0 High Speed and ethernet. Basic aspects influencing the overall accuracy of 3D position measurement are discussed in the contribution. This work is primarily focused on a simple task of object position evaluation in 3D. The problem is significantly simplified by utilizing an easily detectable object marker. Having realized the basic measurement we have shown that the overall position measurement precision nonlinearity is better than 0.5% from the full range (1000 mm). The aspects influencing the measurement accuracy and repeatability of measurement are also discussed.
Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues. (2001)

PEDF, originally reported as a product of RPE cells, is present in photoreceptors and inner retinal cell types in developing and adult human eyes. Photoreceptors and RPE may secrete PEDF into the IPM.
Mechanically flexible thin-film transistors that use ultrathin ribbons of silicon derived from bulk wafers (2006)

This letter introduces a type of thin-film transistor that uses aligned arrays of thin (submicron) ribbons of single-crystal silicon created by lithographic patterning and anisotropic etching of bulk silicon (111) wafers. Devices that incorporate such ribbons printed onto thin plastic substrates show good electrical properties and mechanical flexibility. Effective device mobilities, as evaluated in the linear regime, were as high as 360cm2V−1s−1, and on/off ratios were &amp;gt;103. These results may represent important steps toward a low-cost approach to large-area, high-performance, mechanically flexible electronic systems for structural health monitors, sensors, displays, and other applications.
Homologous and heterologous recombination between adenovirus vector DNA and chromosomal DNA (2008)

These results extend previous information on the integration patterns of adenovirus vector DNA and contribute to a risk-benefit assessment of adenovirus-mediated gene transfer.
Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer (2015)

Emerging evidence has highlighted the host immune system in modulating the patient response to chemotherapy, but the mechanism of this modulation remains unclear. The aim of this study was to analyze the effect of chemotherapy on antitumor immunity in the tumor microenvironment of ovarian cancer. Treatment of ovarian cancer cell lines with various chemotherapeutic agents resulted in upregulated expression of MHC class I and programmed cell death 1 ligand 1 (PD-L1) in a NF-κB-dependent manner and suppression of antigen-specific T-cell function in vitro. In a mouse model of ovarian cancer, treatment with paclitaxel increased CD8(+) T-cell infiltration into the tumor site, upregulated PD-L1 expression, and activated NF-κB signaling. In particular, tumor-bearing mice treated with a combination of paclitaxel and a PD-L1/PD-1 signal blockade survived longer than mice treated with paclitaxel alone. In summary, we found that chemotherapy induces local immune suppression in ovarian cancer through NF-κB-mediated PD-L1 upregulation. Thus, a combination of chemotherapy and immunotherapy targeting the PD-L1/PD-1 signaling axis may improve the antitumor response and offers a promising new treatment modality against ovarian cancer.
Interaction of adenoviral E4 and E1b products in late gene expression (1990)

The adenovirus 294R protein of E4 ORF 6 forms a physical and functional complex with the 496R protein product of E1b. The E4 294R ORF 6 protein also functions in parallel with the E4 116R ORF 3 protein in viral late protein synthesis. We have examined the roles of these three proteins and the protein complex in viral late protein synthesis and late message metabolism, by comparing the phenotypes of E4 294R-, E4 116R-, and E1b 496R- mutants to those of a series of double mutants. Our data indicate that the 294R and 116R proteins act in parallel to permit the accumulation of normal levels of unprocessed late viral RNA in the nucleus of infected cells. Both 294R and 496R function in parallel with the 116R protein in viral nuclear RNA accumulation, but do so to different degrees, suggesting that 294R and 496R may have roles apart from the functional complex in mediating accumulation of viral messages in the nucleus, or that they have nonequivalent roles within the complex. Our results are also consistent with a role for the 496R/294R protein complex in mediating efficient transport of late messages from the nucleus to the cytoplasm and/or in maintaining the stability of those messages on reaching the cytoplasm, as suggested previously (S. Pilder, M. Moore, J. Logan, and T. Shenk, 1986, Mol. Cell. Biol. 6, 470-476). Finally the 116R protein seems to act in parallel with the complex to permit normal viral DNA replication.
Morse Stretch Potential Charge Equilibrium Force Field for Ceramics: Application to the Quartz-Stishovite Phase Transition and to Silica Glass (1999)

To predict phase transitions in ceramics and minerals from molecular dynamics simulations, we have developed a force field in which the charges are allowed to readjust instantaneously to the atomic configurations. These charges are calculated using the charge equilibration (QEq) method. In addition to electrostatics, a two-body Morse stretch potential is included to account for short-range nonelectrostatic interactions. This MS-Q potential is applied herein to $\mathrm{SiO}{}_{2}$, where we find that it describes well the fourfold coordinated and sixfold coordinated systems (such as quartz and stishovite), silica glass, and the pressure-induced phase transition from quartz to stishovite.
Chronic Lymphoid Leukemias (2001)

Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters!Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering a
Folded Optical Delay Lines (1965)

A long optical path has been folded between two 7.5-cm diam spherical or aspherical mirrors to provide an output beam which can be well separated from previous reflections with 1000 or more passes between the mirrors. The 3000-m path provides 10 μsec of delay. This system can be used as a dispersionless optical delay line for use in filtering or storage of information modulated onto the light beam. The pattern of beams between the two mirrors is obtained in one of two ways. A small perturbing mirror may be inserted to give a series of offset ellipses, or one or both of the mirrors can be made astigmatic to give a Lissajous pattern of spots on each mirror. The output beam can be separated from others by discriminating in both angle and position. The diffraction losses of the system are much lower than those for an open beam because of the periodic focusing of the spherical mirrors. The extreme dependence of the loss of the delay line upon the absorption and scattering loss of the mirrors makes the system dependent upon very low loss mirrors and also makes the system a suitable method for measuring mirror loss. Block diagrams are shown for some possible filtering and storage applications.
A Novel Eye Location Algorithm based on Radial Symmetry Transform (2006)

A novel and robust eye location algorithm is proposed in this paper. The algorithm is based on a low level, context free generalized symmetry transform. Once the regions of interest are detected, characteristics of eyes can be used to improve detection results. The algorithm is tested using 1460 face images of the BioID database and 2730 images of the BANCA database. A fully automatic face verification system has also been developed using this eye location algorithm. The system was one of the top performers in the 2004 International Face Verification Competition
Aqueous Humor Flow in Normal Human Eyes Treated With Brimonidine and Timolol, Alone and in Combination (2001)

Brimonidine suppressed aqueous humor flow, but not as effectively as timolol. However, the effects on the IOP of both drugs separately were comparable. The short-term effect of brimonidine was partly additive to timolol, and the combination treatment caused a further reduction in aqueous humor flow and IOP. The IOP reduction by timolol could be explained solely by aqueous humor flow reduction. Much of the IOP reduction caused by brimonidine, but not all, could be explained by suppression of the aqueous humor flow, suggesting an additional mechanism for the ocular hypotensive effect of brimonidine.
Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron (2018)

FCM is an effective therapy in patients with IDA who have GI disorders and has a safety profile comparable to that of other IV iron agents.
Comparisons of the Ability of Human IgG3 Hinge Mutants, IgM, IgE, and IgA2, to Form Small Immune Complexes: A Role for Flexibility and Geometry (1998)

Various native and hinge-modified forms of Ig with identical Ids were reacted with an anti-Id mAb, and the resultant immune complexes were analyzed by negative stain immunoelectron microscopy. Complexes were scored for their geometry (linear versus ring complexes) and size (dimer, trimer, etc.). Ring dimers are the thermodynamically most favorable configuration, unless inhibited by steric and/or flexibility constraints. We found ring dimerization to correlate with the length of the upper, but not middle or lower, hinge. In contrast, the geometry and size of complexes of those molecules lacking formal hinges were unpredictable. A hingeless IgG mutant and native IgE readily formed ring dimers. Remarkably, monomeric IgM formed more ring dimers than any of the other Igs tested, including IgG3. We also tagged the Fab arms and measured the mean Fab-Fab angles and the degree of angular variation for each type of Ig. Surprisingly, IgM proved the most flexible by this assay. In hinged Igs, there was a correlation between length of the upper hinge and Fab-Fab flexibility. In contrast, we found no correlation between the mean Fab-Fab angle in uncomplexed Igs and their ability to dimerize with anti-Id mAb. These data suggest that the physicochemical methods typically used to evaluate molecular flexibility are often of low predictive value when tested in a functional assay.
Antipermeability and antiproliferative effects of standard and frozen bevacizumab on choroidal endothelial cells (2006)

Bevacizumab significantly reduces VEGF-induced permeability and proliferation of CECs. Freezing and thawing of bevacizumab will affect its biological activity.
Emblica officinalis Gaertn and serum cholesterol level in experimental rabbits. (1981)

Twelve albino rabbits of either sex weighing 1.0-1.25 kg were fed a standard laboratory diet of green grass and sattu (roasted Bengal gram). After a 2-week run-in period their serum cholesterol levels were estimated. All animals were now fed 0.5 g cholesterol and 1.0 g clarified butter daily and were not divided into 3 groups of 4 animals each. While all received the standard cholesterol-rich diet, Group A animals received no additional substances, animals in Group B were each fed 10 mg vitamin C daily, while those in Group C were each given 1.0 g fresh Amla (Emblica officinalis Gaertn). Mean serum cholesterol levels in all three groups rose to significantly higher levels by the end of the second week. There was a further rise by the end of the third and fourth weeks in Groups A and B. However, animals in Group C (i.e. those given Amla) showed significantly lower mean serum cholesterol levels at the end of the second week than their counterparts in Groups A and B. At the end of the third and fourth weeks the differences were even more pronounced.
From DNA damage to G2 arrest: the many roles of topoisomerase II. (2003)

DNA topoisomerase II inhibitors are among the most widely used anticancer agents. These drugs are potent inducers of DNA strand breaks and G2 arrest. However, topoisomerase II is not only a target for anti-cancer drugs but also part of the cellular response to different types of DNA damage. Topoisomerase II forms molecular complexes with important cell cycle regulators including the p53 oncogene suppressor, the BRCT-containing protein TopBP1, 14-3-3 epsilon and Cdc2 kinase. The association between topoisomerase II and Cdc2 kinase likely represents the earliest step in mitotic chromatin condensation. Therefore, regulation of the topoisomerase II/Cdc2 interaction could represent a novel mechanism to delay mitotic onset.
Robotics for telesurgery: second generation Berkeley/UCSF laparoscopic telesurgical workstation and looking towards the future applications (2003)

Robotic telesurgery is a promising application of robotics to medicine, aiming to enhance the dexterity and sensation of regular and minimally invasive surgery through using millimeter‐scale robotic manipulators under the control of the surgeon. In this paper, the telesurgical system will be introduced with discussion of kinematic and control issues and presentation of in vitro experimental evaluation results.
Timing of Closure of Open Fractures (2002)

Traditionally, closure of open fractures after initial debridement has been delayed to minimize the risk of complications, particularly infection. This practice developed before the widespread use of systemic antibiotics, local antibiotic bead pouches, advanced debridement methods, and improved fracture stabilization techniques. Current evidence indicates that infections after treatment of open fractures frequently are not caused by initial contaminating organisms but often are acquired in the hospital. Recent studies comparing primary with delayed closure have not demonstrated an increased rate of complications. Considering the improvements in open fracture wound care, the increasing incidence of resistant nosocomial infections, and the cost implications of a dogmatic delayed-closure strategy, wound care protocols for open fractures should be reevaluated. Because of lack of data specifically addressing the timing of closure of such wounds, studies comparing primary versus delayed closure are needed.
Action of Low Calcemic 1 ,25-Dihydroxyvitamin D3 Analogue EB1089 in Head and Neck Squamous Cell Carcinoma (2001)

EB1089 completely inhibited growth of AT-84 SCC cells at nanomolar concentrations, reduced tumor growth, and did not have calcemic effects. Our results support continued investigation of EB1089 as a chemopreventive/chemotherapeutic agent for head and neck SCC.
Substrate specificity of Epstein-Barr virus thymidine kinase (1994)

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.
Ehrlichia canis gp200 Contains Dominant Species-Specific Antibody Epitopes in Terminal Acidic Domains (2007)

Species-specific antibody epitopes within several major immunoreactive protein orthologs of Ehrlichia species have recently been identified and molecularly characterized. In this study, dominant B-cell epitopes within the acidic (pI 5.35) ankyrin repeat-containing 200-kDa major immunoreactive protein (gp200) of Ehrlichia canis were defined. The E. canis gp200 gene (4,263 bp; 1,421 amino acids) was cloned and expressed as four (N-terminal, 1,107 bp; N-internal, 910 bp; C-internal, 1,000 bp; and C-terminal, 1,280 bp) overlapping recombinant proteins. The N-terminal, C-internal, and C-terminal polypeptides (369, 332, and 426 amino acids, respectively) were strongly recognized by antibody, and the major epitope(s) in these polypeptides was mapped to four polypeptide regions (40 to 70 amino acids). Smaller overlapping recombinant polypeptides (14 to 15 amino acids) spanning these regions identified five strongly immunoreactive species-specific epitopes that exhibited conformational dependence. The majority of the epitopes (four) were located in two strongly acidic (pI 4 to 4.9) domains in the distal N- and C-terminal regions of the protein flanking the centralized ankyrin domain-containing region. The amino acid content of the epitope-containing domains included a high proportion of strongly acidic amino acids (glutamate and aspartate), and these domains appear to have important biophysical properties that influence the antibody response to gp200.
HPLC method for quantitating ergovaline in endophyte-infested tall fescue: seasonal variation of ergovaline levels in stems with leaf sheaths, leaf blades, and seed heads (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHPLC method for quantitating ergovaline in endophyte-infested tall fescue: seasonal variation of ergovaline levels in stems with leaf sheaths, leaf blades, and seed headsGeorge E. Rottinghaus, George B. Garner, Creighton N. Cornell, and James L. EllisCite this: J. Agric. Food Chem. 1991, 39, 1, 112–115Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jf00001a022https://doi.org/10.1021/jf00001a022research-articleACS PublicationsRequest reuse permissionsArticle Views640Altmetric-Citations191LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Gastroduodenal HCO3(-) transport: characteristics and proposed role in acidity regulation and mucosal protection (1982)

Gastric HCO3(-) transport (basal) studied in isolated amphibian mucosa and mammalian stomach in vivo amounts to 2-10% of maximal H+ secretion. Duodenal mucosa, devoid of Brunner's glands, transports HCO3(-) at a greater rate (per unit surface area) than either stomach or jejunum in vitro and in vivo. Gastric (but not duodenal) HCO3(-) transport is stimulated by dibutyryl cGMP, carbachol, and cholecystokinin and duodenal (but not gastric) transport by dibutyryl cAMP and gastric inhibitory peptide. Glucagon and E- and F-type prostaglandins stimulate, whereas histamine, gastrin, and secretin are without effect in both stomach and duodenum. Gastric transport very probably occurs by Cl--HCO3(-) exchange at the luminal membranes of the surface epithelial cells. In addition to this mechanism, the duodenum also transports HCO3(-) electrogenically. Lowering the luminal pH increases transport in both the stomach and duodenum. This response, probably mediated via both local production of prostaglandins and tissue-specific humoral agents, may be important in mucosal protection against acid. Metabolism-dependent transport of HCO3(-), stimulated by acid, seems quantitatively sufficient to account for all of the duodenal and most of the gastric mucosa's ability to remove luminal acid.