gebhart/patrepeval huggingface dataset:
On the Use of EEG or MEG Brain Imaging Tools in Neuromarketing Research (2011)

Here we present an overview of some published papers of interest for the marketing research employing electroencephalogram (EEG) and magnetoencephalogram (MEG) methods. The interest for these methodologies relies in their high-temporal resolution as opposed to the investigation of such problem with the functional Magnetic Resonance Imaging (fMRI) methodology, also largely used in the marketing research. In addition, EEG and MEG technologies have greatly improved their spatial resolution in the last decades with the introduction of advanced signal processing methodologies. By presenting data gathered through MEG and high resolution EEG we will show which kind of information it is possible to gather with these methodologies while the persons are watching marketing relevant stimuli. Such information will be related to the memorization and pleasantness related to such stimuli. We noted that temporal and frequency patterns of brain signals are able to provide possible descriptors conveying information about the cognitive and emotional processes in subjects observing commercial advertisements. These information could be unobtainable through common tools used in standard marketing research. We also show an example of how an EEG methodology could be used to analyze cultural differences between fruition of video commercials of carbonated beverages in Western and Eastern countries.
Decreased GA1 Content Caused by the Overexpression ofOSH1 Is Accompanied by Suppression of GA 20-Oxidase Gene Expression (1998)

We previously reported that overexpression of the rice homeobox gene OSH1 led to altered morphology and hormone levels in transgenic tobacco (Nicotiana tabacum L.) plants. Among the hormones whose levels were changed, GA1 was dramatically reduced. Here we report the results of our analysis on the regulatory mechanism(s) of OSH1 on GA metabolism. GA53 and GA20, precursors of GA1, were applied separately to transgenic tobacco plants exhibiting severely changed morphology due to overexpression of OSH1. Only treatment with the end product of GA 20-oxidase, GA20, resulted in a striking promotion of stem elongation in transgenic tobacco plants. The internal GA1 and GA20 contents in OSH1-transformed tobacco were dramatically reduced compared with those of wild-type plants, whereas the level of GA19, a mid-product of GA 20-oxidase, was 25% of the wild-type level. We have isolated a cDNA encoding a putative tobacco GA 20-oxidase, which is mainly expressed in vegetative stem tissue. RNA-blot analysis revealed that GA 20-oxidase gene expression was suppressed in stem tissue of OSH1-transformed tobacco plants. Based on these results, we conclude that overexpression of OSH1 causes a reduction of the level of GA1 by suppressing GA 20-oxidase expression.
Effects of the ETB-Selective Antagonist IRL 2500 in Conscious Spontaneously Hypertensive and Wistar-Kyoto Rats (1995)

The pharmacologic profile of a novel and selective ETB antagonist, IRL 2500 (N-(3,5-dimethylbenzoyl)-N-methyl-(D)-(4-phenylphenyl)-alany l-L-tryptophan) was examined in conscious spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. The initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620 (0.5 nmol/kg, i.v.) was significantly reduced in conscious WKY rats pretreated with IRL 2500 (10 mg/kg, i.v.). The secondary and sustained pressor response to these agonists, however, was not altered by IRL 2500. The linear peptide antagonist BQ 788, although also inhibiting the initial depressor responses, attenuated the secondary pressor response to IRL 1620 and potentiated the pressor response to ET-1. IRL 2500, administered alone to naive conscious SHRs produced a -37 +/- 8 mm Hg reduction in blood pressure, followed by a secondary pressor response (+38 +/- 7 mm Hg) with a duration exceeding 90 min. Pretreatment with either the ETA-selective antagonist BQ 123 or with the nonselective ETA/ETB antagonist SB 209670 resulted in marked potentiation of the depressor response and significant attenuation of the secondary rise in pressure. These results indicate that in the conscious rat, IRL 2500 acts as an ETB1-selective antagonist. In addition, ETA receptor activation contributes to the sustained pressore response to IRL 2500 in the conscious SHR. Furthermore, IRL 2500 may also exert a non-ET receptor-mediated vasodilation in the SHR.
Hypersensitivity of Spinothalamic Tract Neurons Associated With Diabetic Neuropathic Pain in Rats (2002)

Diabetic neuropathic pain is often considered to be caused by peripheral neuropathy. The involvement of the CNS in this pathological condition has not been well documented. Development of hypersensitivity of spinal dorsal horn neurons is involved in neuropathic pain induced by traumatic nerve injury. In the present study, we determined the functional changes of identified spinothalamic tract (STT) neurons and their correlation to diabetic neuropathic pain. Diabetes was induced in rats by intraperitoneal injection of streptozotocin. Hyperalgesia and allodynia were assessed by the withdrawal responses to pressure, radiant heat, and von Frey filaments applied to the hindpaw. Single-unit activity of STT neurons was recorded from the lumbar spinal cord in anesthetized rats. The responses of STT neurons to mechanical and thermal stimuli and the sensitivity to intravenous morphine were determined in diabetic and normal rats. In 12 diabetic rats, mechanical allodynia and hyperalgesia, but not thermal hyperalgesia, developed within 2 wk after streptozotocin injection and lasted for >/=7 wk. Compared to the 32 STT neurons recorded in normal animals, the 37 STT neurons in diabetic rats displayed a higher spontaneous discharge activity and enlarged receptive fields. Also, the STT neurons in diabetic rats exhibited lower thresholds and augmented responses to mechanical stimulation. Intravenous injection of 2.5 mg/kg of morphine suppressed significantly the responses of STT neurons to noxious stimuli in 12 nondiabetic rats. However, such an inhibitory effect of morphine on the evoked response of STT neurons was diminished in 14 diabetic animals. This electrophysiological study provides new information that development of hypersensitivity of spinal dorsal horn projection neurons may be closely related to neuropathic pain symptoms caused by diabetes. Furthermore, the attenuated inhibitory effects of morphine on evoked responses of STT neurons in diabetes likely accounts for its reduced analgesic efficacy in this clinical form of neuropathic pain.
<title>Micromachining of diamond substrates with waveguide excimer lasers</title> (1994)

Waveguide excimer lasers in combination with high-resolution imaging and precision motion control systems are capable of direct-write shaping of diamond and diamond-like materials. 3D structures can be produced by scanning the worksurface under the focused beam and varying the energy delivered to the worksurface through use of various exposure algorithms. Using this technique, we have produced microstructures in diamond that demonstrated high spatial resolution and good surface finish.
Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs (2011)

Although the activation of β2AR-T4L requires the insertion of the T4 lysozyme sequence and the yield of that active protein limited, our results conceptually prove that cell-free protein expression could be used as a fast approach to express these valuable and notoriously difficult-to-express proteins.
Analytic Considerations and Design Basis for the IEEE Distribution Test Feeders (2017)

For nearly 20 years, the Test Feeder Working Group of the Distribution System Analysis Subcommittee has been developing openly available distribution test feeders for use by researchers. The purpose of these test feeders is to provide models of distribution systems that reflect the wide diversity in design and their various analytic challenges. Because of their utility and accessibility, the test feeders have been used for a wide range of research, some of which has been outside the original scope of intended uses. This paper provides an overview of the existing distribution feeder models and clarifies the specific analytic challenges that they were originally designed to examine. Additionally, this paper will provide guidance on which feeders are best suited for various types of analysis. The purpose of this paper is to provide the original intent of the Working Group and to provide the information necessary so that researchers may make an informed decision on which of the test feeders are most appropriate for their work.
<title>Interactive 3D visualization tools for stereotactic atlas-based functional neurosurgery</title> (1998)

Many of the critical basal ganglia structures are not distinguishable on anatomical magnetic resonance imaging (MRI) scans, even though they differ in functionality. In order to provide the neurosurgeon with this missing information, a deformable volumetric atlas of the basal ganglia has been created from the Shaltenbrand and Wahren atlas of cryogenic slices. The volumetric atlas can be non-linearly deformed to an individual patient's MRI. To facilitate the clinical use of the atlas, a visualization platform has been developed for pre- and intra-operative use which permits manipulation of the merged atlas and MRI data sets in two- and three-dimensional views. The platform includes graphical tools which allow the visualization of projections of the leukotome and other surgical tools with respect to the atlas data, as well as pre- registered images from any other imaging modality. In addition, a graphical interface has been designed to create custom virtual lesions using computer models of neurosurgical tools for intra-operative planning. To date 17 clinical cases have been successfully performed using the described system.
Slewing Multimode Flexible Spacecraft with Zero Derivative Robustness Constraints (1997)

References 1Lim, K. B., and Gawronski, W., “Actuator and Sensor Placement for Control of Flexible Structures,” Control and Dynamics Systems, edited by C. T. Leondes, Vol. 57, Academic, San Diego, CA, 1993, pp. 109–152. 2Gawronski, W., and Lim, K. B., “Balanced Actuator and Sensor Placement for Flexible Structures,” International Journal of Control (to be published); also AIAA Paper 95-3259. 3Lim, K. B., and Gawronski, W., “Hankel Singular Values of Flexible Structures in Discrete Time,” Journal of Guidance, Control, and Dynamics, Vol. 19, No. 6, 1996, pp. 1370–1377; also AIAA Paper 96-3757, 1996. 4Gregory, C. Z., Jr., “Reduction of Large Flexible Spacecraft Models Using Internal Balancing Theory,” Journal of Guidance, Control, and Dynamics, Vol. 7, No. 6, 1984, pp. 725–732. 5Boyd, S. P., and Barratt, C. H., Linear Controller Design: Limits of Performance, Prentice–Hall, Englewood Cliffs, NJ, 1991, Chap. 2. 6Gawronski, W., and Williams, T., “Model Reduction for Flexible Space Structures,” Journal of Guidance, Control, and Dynamics, Vol. 14, No. 1, 1991, pp. 68–76. 7Moore, B. C., “Principal Component Analysis in Linear Systems: Controllability,Observability andModel Reduction,” IEEE Transactions on Automatic Control, Vol. 26, No. 1, 1981, pp. 17–32.
Network Assisted Content Distribution for Adaptive Bitrate Video Streaming (2017)

State-of-the-art Software Defined Wide Area Networks (SD-WANs) provide the foundation for flexible and highly resilient networking. In this work we design, implement and evaluate a novel architecture (denoted SABR) that leverages the benefits of SDN to provide network assisted Adaptive Bitrate Streaming. With clients retaining full control of their streaming algorithms we clearly show that by this network assistance, both the clients and the content providers benefit significantly in terms of QoE and content origin offloading. SABR utilizes information on available bandwidths per link and network cache contents to guide video streaming clients with the goal of improving the viewer's QoE. In addition, SABR uses SDN capabilities to dynamically program flows to optimize the utilization of CDN caches.; [email protected] by our study of SDN assisted streaming we discuss the change in the requirements for network-to-player APIs that enables flexible video streaming. We illustrate the difficulty of the problem and the impact of SDN-assisted streaming on QoE metrics using various well established player algorithms. We evaluate SABR together with state-of-the-art DASH quality adaptation algorithms through a series of experiments performed on a real-world, SDN-enabled testbed network with minimal modifications to an existing DASH client. Our measurements show the substantial improvement in cache hitrates in conjunction with SABR indicating a rich design space for jointly optimized SDN-assisted caching architectures for video streaming applications.
Characterization of MHC Ligands for Peptide Based Tumor Vaccination (2009)

Short peptides derived from cellular proteins may escape complete destruction during protein catabolism and finally serve as a showcase in the immune system. Exposed at the cell surface to scrutiny by T cells, MHC:peptide complexes mediate a highly specific and immediate information transfer from diseased cells to the cellular immune system. Numerous clinical vaccination trials have been carried out employing MHC-presented peptides for T-cell activation with encouraging results but so far without a final breakthrough. In this review, we briefly highlight the molecular basis of MHC-peptide interactions governed by specificity pockets and anchor residues, as summarized in allele-specific peptide motifs. State-of-the-art technology is comprehensively presented and gives an overview of modern mass spectrometric strategies used for qualitative and quantitative analysis of MHC ligands. We describe the details of the HLA-B*3801 peptide motif by comparing features of natural MHC ligands, resulting in a scoring matrix that enables epitope prediction from any viral or tumor antigen. The pronounced individuality in peptide presentation by MHC molecules, as reflected in the highly specific peptide motifs of different MHC allotypes or the tissue-specific MHC ligandomes, represents a current area of interest within this field. Finally, the identification of post-translational modifications--most important phosphorylations--and the promises this holds will be discussed in this chapter.
A phase 1b study of the anti-PD-1 monoclonal antibody BGB-A317 (A317) in combination with the PARP inhibitor BGB-290 (290) in advanced solid tumors. (2018)

48 Background: The release of tumor-associated antigens may enhance the response to immunotherapy. BGB-A317, a humanized IgG4 variant monoclonal antibody engineered to have no Fc gamma receptor binding, targets the programmed cell death-1 (PD-1) receptor. It is being developed in solid and hematologic malignancies at a dose of 200 mg IV Q3W. BGB-290, a potent inhibitor of PARP 1/2, is hypothesized to promote neoantigen release that may potentially increase the efficacy of BGB-A317. A phase 1 study identified 60 mg BID as the recommended Phase 2 dose (RP2D) for BGB-290. This study consists of initial dose escalation to determine the maximum-tolerated dose (MTD), safety, pharmacokinetic (PK) profile, and preliminary antitumor activity of the combination, followed by expansion into ovarian, breast, prostate, gastric, bladder, pancreatic and small cell lung cancers. Methods: Cohorts of 6–12 patients with advanced solid tumors were treated in each of 5 planned dose levels (DLs). In DLs 1–3, BGB-290 doses ranged between 20–60 mg PO BID with BGB-A317 2 mg/kg IV Q3W. In DLs 4–5, BGB-290 doses were 40 or 60 mg BID; A317 was given at 200 mg IV Q3W based on PK data from a single agent Phase 1 study. Results: As of 31 March 2017, 43 patients [median age 63 years (34–75)] were treated in DLs 1–5. Three patients experienced four dose-limiting toxicities: grade 2 nausea (DL4), grade 2 nausea and grade 2 vomiting (DL5), and grade 4 autoimmune hepatitis (DL5). MTD was identified as BGB-A317 200 mg IV Q3W + BGB-290 40 mg PO BID. The most common adverse event (AE) considered related to both study drugs was fatigue. Immune-related AEs of Grade ≥3 were elevated alanine aminotransferase/aspartate aminotransferase (n = 3), autoimmune hepatitis (n = 3), and hepatitis (n = 1). Complete or partial response was observed in 11 patients, 4 of whom had confirmed PR or CR. Plasma/serum exposure of BGB-290 and BGB-A317 were consistent with those in single-agent trials. Conclusions: The combination of BGB-A317 and BGB-290 was generally well tolerated in patients with advanced solid tumors. These results support the continuation of this trial with enrollment into the disease-specific cohorts. Clinical trial information: NCT02660034.
Genetic risk for colitis-associated colorectal cancer (2009)

The development of colorectal cancer (CRC) is arguably the most feared complication of ulcerative colitis. Clinical variables correlated with the development of CRC in patients with ulcerative colitis include age at onset, duration and geographical extent of disease, and concomitant primary sclerosing cholangitis (PSC). Patients with ulcerative colitis and with extensive duration of disease or pancolitis have a cumulative lifetime risk of CRC that exceeds 30%.1 Although the pathogenesis of CRC that develops in patients with ulcerative colitis is poorly understood, several studies have identified molecular features that distinguish CRC associated with ulcerative colitis from sporadic CRC.2 3 4 5 CRC that develops in patients with ulcerative colitis is most common in the rectum and sigmoid colon, almost always occurs in areas involved by chronic inflammation, and is more frequently characterised by multiple synchronous tumours than is sporadic CRC.6 It is generally preceded by dysplasia, which therefore provides cogent rationale for colonoscopic surveillance for CRC in patients with ulcerative colitis, particularly those with pancolitis and extended duration of disease.

Although a large number of germline and somatic genetic lesions have been associated with a predisposition to the development of CRC, little is known about the extent to which genetic factors may influence the risk for development of CRC in patients with ulcerative colitis. In this issue of Gut , Garrity-Park and colleagues7 ( see page 1226 ) now report that risk for the development of CRC in patients with ulcerative colitis is associated with specific HLA-DR and HLA-DQ alleles encoded at loci within the class II region of the major histocompatibility complex (MHC) on chromosome 6p. The HLA-DR and HLA-DQ molecules are heterodimeric cell surface proteins that present polypeptide antigens derived primarily from extracellular sources to CD4 + T lymphocytes, and play multiple critical roles in adaptive immunity. …
Research on weighted link based routing protocol for wireless mesh network (2007)

Although wireless mesh network is one of the most hotspots in wireless network field, the routing protocol standardization is still on the way. In this paper, an improved routing protocol based on AODV, MODVWLS, is proposed by using weighted path as routing metric. The weight of each hop, which is composed of node&apos;s available bandwidth, buffer queue and throughput, is accumulated, and the path with minimal weight from source to destination is finally used as preferred route. Weight calculation, message formats, route discovering and maintenance process are also introduced. Finally, several simulations are conducted by ns-2, and results show that due to utilizing disengaged nodes sufficiently and balancing network load perfectly, MODVWLS is better than AODV on packet delivery fraction, average end-to-end delay and normalized routing load, so it is more suitable for wireless network.
Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents (2005)

Acne is the most common cutaneous disorder of multifactorial origin with a prevalence of 70-85% in adolescents. The majority of the acne sufferers exhibit mild to moderate acne initially, which progresses to the severe form in certain cases. Topical therapy is employed as first-line treatment in mild acne, whereas for moderate and severe acne, systemic therapy is required in addition to topical therapy. Currently, several topical agents are available that affect at least one of the main pathogenetic factors responsible for the development of acne. Although topical therapy has an important position in acne treatment, side effects associated with various topical antiacne agents and the undesirable physicochemical characteristics of certain important agents like tretinoin and benzoyl peroxide affect their utility and patient compliance. Novel drug delivery strategies can play a pivotal role in improving the topical delivery of antiacne agents by enhancing their dermal localization with a concomitant reduction in their side effects. The current review emphasizes the potential of various novel drug delivery strategies like liposomes, niosomes, aspasomes, microsponges, microemulsions, hydrogels and solid lipid nanoparticles in optimizing and enhancing the topical delivery of antiacne agents.
InP-Based High Electron Mobility Transistors with a Very Short Gate-Channel Distance (2003)

We fabricated 25-nm-gate lattice-matched InAlAs/InGaAs high electron mobility transistors (HEMTs) with a very short gate-channel distance. Using the two-step-recessed gate technique, we reduced the gate-channel distance to 4 nm. We found that the cutoff frequency fT increases with decreasing gate-channel distance d. This phenomenon can be explained by an increase in electron velocity under the gate with decreasing d. We obtained an fT of 500 GHz with a d of 4 nm. We also fabricated 25-nm-gate pseudomorphic In0.52Al0.48As/In0.7Ga0.3As HEMTs using the same processing technique, and obtained an fT of 562 GHz with a d of 4 nm. This fT is the highest value yet reported for a transistor of any type.
Interferon‐γ–dependent inhibition of B cell activation by bone marrow–derived mesenchymal stem cells in a murine model of systemic lupus erythematosus (2010)

Our findings indicate that BM-MSCs affect B cell receptor-dependent activation of both follicular and marginal zone B cells from lupus mice. This inhibitory effect is IFNγ-dependent and cell contact-dependent. MSCs in vivo do not affect the production of autoantibodies, the level of proteinuria, or the mortality rates. Nonetheless, the significant improvement in histologic findings in the kidney supports the potential role of MSCs in the prevention of glomerular damage.
Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension (2008)

clinicaltrials.gov Identifier: NCT00288184.
TIP49b, a Regulator of Activating Transcription Factor 2 Response to Stress and DNA Damage (2001)

Activating transcription factor 2 (ATF2/CRE-BP1) is implicated in transcriptional control of stress-responsive genes. A yeast two-hybrid screen identified TBP-interacting protein 49b (TIP49b), a component of the INO80 chromatin-remodeling complex, as a novel ATF2-interacting protein. TIP49b's association with ATF2 is phosphorylation dependent and requires amino acids 150 to 248 of ATF2 (ATF2(150-248)), which are implicated in intramolecular inhibition of ATF2 transcriptional activities. Forced expression of TIP49b efficiently attenuated ATF2 transcriptional activities under normal growth conditions as well as after UV treatment, ionizing irradiation, or activation of p38 kinase, all of which induced ATF2 phosphorylation and increased TIP49b-ATF2 association. Constitutive expression of ATF2(150-248) peptide outcompeted TIP49b interaction with ATF2 and alleviated the suppression of ATF2 transcriptional activities. Expression of ATF2(150-248) in fibroblasts or melanoma but not in ATF2-null cells caused a profound G(2)M arrest and increased degree of apoptosis following irradiation. The interaction between ATF2 and TIP49b constitutes a novel mechanism that serves to limit ATF2 transcriptional activities and highlights the central role of ATF2 in the control of the cell cycle and apoptosis in response to stress and DNA damage.