gebhart/patrepeval huggingface dataset:
High throughput low power decoder architectures for low density parity check codes (2005)

A high throughput scalable decoder architecture, a tiling approach to reduce the\ncomplexity of the scalable architecture, and two low power decoding schemes have been\nproposed in this research. The proposed scalable design is generated from a serial\narchitecture by scaling the combinational logic; memory partitioning and constructing a\nnovel H matrix to make parallelization possible. The scalable architecture achieves a high\nthroughput for higher values of the parallelization factor M. The switch logic used to\nroute the bit nodes to the appropriate checks is an important constituent of the scalable\narchitecture and its complexity is high with higher M. The proposed tiling approach is\napplied to the scalable architecture to simplify the switch logic and reduce gate\ncomplexity.\nThe tiling approach generates patterns that are used to construct the H matrix by\nrepeating a fixed number of those generated patterns. The advantages of the proposed\napproach are two-fold. First, the information stored about the H matrix is reduced by onethird.\nSecond, the switch logic of the scalable architecture is simplified. The H matrix information is also embedded in the switch and no external memory is needed to store the\nH matrix.\nScalable architecture and tiling approach are proposed at the architectural level of the\nLDPC decoder. We propose two low power decoding schemes that take advantage of the\ndistribution of errors in the received packets. Both schemes use a hard iteration after a\nfixed number of soft iterations. The dynamic scheme performs X soft iterations, then a\nparity checker cHT that computes the number of parity checks in error. Based on cHT\nvalue, the decoder decides on performing either soft iterations or a hard iteration. The\nadvantage of the hard iteration is so significant that the second low power scheme\nperforms a fixed number of iterations followed by a hard iteration. To compensate the bit\nerror rate performance, the number of soft iterations in this case is higher than that of\nthose performed before cHT in the first scheme.
Micro Channel Heat Exchanger for Cooling Electrical Equipment (1998)

Abstract The micro channel heat exchanger, which has many small channels (10–100 μm order), is a promising device to cool an integrated circuit, which generates a large amount of heat. In order to investigate the performance of the micro channel heat exchanger, three-dimensional numerical simulations and experiments on heat transfer behavior and pressure loss were carried out. So far as the heat transfer phenomena is concerned, results obtained using a silicon tip micro channel model a very small thermal resistance, about 0.1(K cm2/W) at Re = 300. And, in the designing of heat exchanger, the pressure loss phenomenon is of practical importance. In the present study, measured pressure loss was good agreement with that of analytical result obtained on the basis of fully developed laminar pipe flow assumption. Furthermore, a practical setup was made with a micro channel heat exchanger to clarify the possibility of using the micro channel heat exchanger in electrical equipment. As a result, it was confirmed that the performance of the micro channel heat exchanger system is sufficient to cool a silicon chip which generates a large amount of heat, and the scale of the system is compact compared to that of the whole setup of electrical equipment.
Insulin‐Like growth factor binding protein (IGFBP) inhibits igf action on human osteosarcoma cells (1991)

The influence of a human insulin-like growth factor binding protein, hIGFBP-1, on the action of IGFs on human osteosarcoma cells was examined. hIGFBP-1 was found to block binding of IGFs to their receptors on MG-63 cells and subsequent IGF stimulation of DNA synthesis. Concurrent incubation of hIGFBP-1 with either 125I-IGF-I or 125I-IGF-II prevented the binding of both 125I-IGFs to cells in a dose-dependent manner. hIGFBP-1 inhibition of IGF binding occurred similarly under both 4 degrees and 37 degrees C conditions. Additionally, hIGFBP-1 facilitated the dissociation of IGFs bound to cells. The inhibitory effect of hIGFBP-1 on IGF-1 mediated 3H-thymidine incorporation into DNA was dose dependent. hIGFBP-1 did not inhibit binding to or stimulation of growth in MG-63 cells by des3-IGF-1, an IGF-I analog with a 100-fold less affinity for hIGFBP-I. This confirmed that hIGFBP-1 competed for IGF receptor binding sites on MG-63. Since hIGFBP-1 did not bind to cells, inhibition of IGF action was indirect, presumably through the formation of extracellular soluble bioinactive IGF-BP complexes.
Role of the Box C/D Motif in Localization of Small Nucleolar RNAs to Coiled Bodies and Nucleoli (1999)

Small nucleolar RNAs (snoRNAs) are a large family of eukaryotic RNAs that function within the nucleolus in the biogenesis of ribosomes. One major class of snoRNAs is the box C/D snoRNAs named for their conserved box C and box D sequence elements. We have investigated the involvement of cis-acting sequences and intranuclear structures in the localization of box C/D snoRNAs to the nucleolus by assaying the intranuclear distribution of fluorescently labeled U3, U8, and U14 snoRNAs injected into Xenopus oocyte nuclei. Analysis of an extensive panel of U3 RNA variants showed that the box C/D motif, comprised of box C', box D, and the 3' terminal stem of U3, is necessary and sufficient for the nucleolar localization of U3 snoRNA. Disruption of the elements of the box C/D motif of U8 and U14 snoRNAs also prevented nucleolar localization, indicating that all box C/D snoRNAs use a common nucleolar-targeting mechanism. Finally, we found that wild-type box C/D snoRNAs transiently associate with coiled bodies before they localize to nucleoli and that variant RNAs that lack an intact box C/D motif are detained within coiled bodies. These results suggest that coiled bodies play a role in the biogenesis and/or intranuclear transport of box C/D snoRNAs.
A biofuel cell based on two immiscible solvents and glucose oxidase and microperoxidase-11 monolayer-functionalized electrodes (1999)

Apo-glucose oxidase was reconstituted onto a pyrroloquinoline quinone and flavin adenine dinucleotide phosphate (PQQ–FAD) monolayer associated with a rough Au electrode to yield a bioelectrocatalytically active glucose oxidase, GOx. An electrically contacted PQQ–FAD/GOx monolayer was applied for the biocatalytic oxidation of glucose in an aqueous electrolyte. Microperoxidase-11, MP-11, was assembled as a monolayer on a rough Au electrode and used for the biocatalytic reduction of cumene peroxide in a dichloromethane electrolyte solution. Both biocatalytic electrodes, Au/PQQ–FAD/GOx and Au/MP-11, were integrated into one system, creating a biofuel cell using glucose and cumene peroxide as the fuel substrate and the oxidizer, respectively, in a two-phase liquid system. The biofuel cell generates an open-circuit voltage, Voc, of ca. 1 V and a short-circuit current density, isc, of ca. 830 µA cm-2. The maximum electrical power, Wmax, extracted from the cell is 520 µW at an external optimal load of 0.4 kΩ. The fill factor of the biofuel cell, f=Wmax · Isc-1 · Voc-1, is ca. 25%. The biofuel cell based on bioelectrocatalytic processes in two immiscible electrolytes shows a significant increase of the evaluated power in comparison with similar electrocatalytic systems in a single-phase aqueous electrolyte.
Influence of capping layer on the current-induced magnetization switching in magnetic nanopillars (2006)

Taking into account the thermal effect, we verify that the strong spin relaxation in the capping layer of a magnetic nanopillar significantly affects the current-induced magnetization switching behavior by reducing the critical switching current density. Theoretical calculations reveal that increasing the spin relaxation in the capping layer enhances the spin-polarized current while suppresses the contribution of the spin accumulation to the magnetization switching. The results suggest that the spin-polarized current, rather than the spin accumulation, dominates the current-induced magnetization switching.
Prostate-Specific Antigen and Human Glandular Kallikrein 2 Are Markedly Elevated in Urine of Patients with Polycystic Ovary Syndrome (2001)

Prostate-specific antigen (PSA) is a well-established tumor marker of prostatic adenocarcinoma. Human glandular kallikrein 2 (hK2), another serine protease closely related to PSA, is also gaining ground as a promising diagnostic tool in prostate cancer. The expression of these 2 proteases is known to be regulated by androgens and progestins in hormonally responsive tissues, such as the male prostate and the female breast. Previously, we have shown that serum PSA levels in normal women are very low but still detectable by ultrasensitive PSA immunoassays. We have also demonstrated that some women with hyperandrogenic syndromes have elevated serum PSA levels. In this study, we have measured urinary PSA and urinary hK2 levels in 35 polycystic ovary syndrome (PCOS) patients and compared them to those of 41 age-matched controls. We found that urinary PSA levels were significantly higher (P < 0.0001) in PCOS patients (mean +/- SE = 820 +/- 344 ng/L) than in the controls (mean +/- SE = 4.3 +/- 1.8 ng/L). Similarly, the difference between urinary hK2 of patients (mean +/- SE = 8.2 +/- 3.1 ng/L) and controls (0.5 +/- 0.3 ng/L) was also significant (P < 0.001). A weak correlation was observed between urinary PSA and serum 3 alpha-androstanediol glucuronide (r(s) = 0.42, P = 0.03) as well as between urinary PSA and serum testosterone (r(s) = 0.40, P = 0.04). The results of this study indicate that urinary PSA, and possibly urinary hK2, are promising markers of hyperandrogenism in females suffering from PCOS.
The dynamics of reinforcement learning in cooperative multiagent systems (1998)

Reinforcement learning can provide a robust and natural means for agents to learn how to coordinate their action choices in multiagent systems. We examine some of the factors that can influence the dynamics of the learning process in such a setting. We first distinguish reinforcement learners that are unaware of (or ignore) the presence of other agents from those that explicitly attempt to learn the value of joint actions and the strategies of their counterparts. We study Q-learning in cooperative multiagent systems under these two perspectives, focusing on the influence of partial action observability, game structure, and exploration strategies on convergence to (optimal and suboptimal) Nash equilibria and on learned Qvalues. 1 Introduction The application of learning to the problem of coordination in multiagent systems (MASs) has become increasingly popular in AI and game theory. The use of reinforcement learning (RL), in particular, has attracted recent attention [22, 17, 16, 13, ...
Carbohydrate analyses with high-performance anion-exchange chromatography (1996)

High-performance anion-exchange chromatography (HPAEC), in tandem with pulsed amperometric detector (PAD) is a powerful tool for carbohydrate analysis. It requires no pre- or postcolumn derivatization, and yet offers superb resolution and sensitiviy. In its basic mode, alcoxide anions from the hydroxyl groups of carbohydrates as well as other anionic substituents are utilized. In addition to the number of hydroxyl groups, separation can be based on anomers, positional isomers, as well as degree of polymerization.
Enterohemorrhagic Escherichia coli O157:H7 Produces Tir, Which Is Translocated to the Host Cell Membrane but Is Not Tyrosine Phosphorylated (1999)

Intimate attachment to the host cell leading to the formation of attaching and effacing (A/E) lesions is an essential feature of enterohemorrhagic Escherichia coli (EHEC) O157:H7 pathogenesis. In a related pathogen, enteropathogenic E. coli (EPEC), this activity is dependent upon translocation of the intimin receptor, Tir, which becomes tyrosine phosphorylated within the host cell membrane. In contrast, the accumulation of tyrosine-phosphorylated proteins beneath adherent EHEC bacteria does not occur, leading to questions about whether EHEC uses a Tir-based mechanism for adherence and A/E lesion formation. In this report, we demonstrate that EHEC produces a functional Tir that is inserted into host cell membranes, where it serves as an intimin receptor. However, unlike in EPEC, in EHEC Tir is not tyrosine phosphorylated yet plays a key role in both bacterial adherence to epithelial cells and pedestal formation. EHEC, but not EPEC, was unable to synthesize Tir in Luria-Bertani medium but was able to secrete Tir into M9 medium, suggesting that Tir synthesis and secretion may be regulated differently in these two pathogens. EHEC Tir and EPEC Tir both bind intimin and focus cytoskeletal rearrangements, indicating that tyrosine phosphorylation is not needed for pedestal formation. EHEC and EPEC intimins are functionally interchangeable, but EHEC Tir shows a much greater affinity for EHEC intimin than for EPEC intimin. These findings highlight some of the differences and similarities between EHEC and EPEC virulence mechanisms, which can be exploited to further define the molecular basis of pedestal formation.
The Viscosities of Solutions of the Proteins of Horse Serum1 (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Viscosities of Solutions of the Proteins of Horse Serum1Kathleen R. Fahey and Arda Alden GreenCite this: J. Am. Chem. Soc. 1938, 60, 12, 3039–3043Publication Date (Print):December 1, 1938Publication History Published online1 May 2002Published inissue 1 December 1938https://pubs.acs.org/doi/10.1021/ja01279a061https://doi.org/10.1021/ja01279a061research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Separation and Identification of Major Plant Sphingolipid Classes from Leaves (2006)

Sphingolipids are major components of the plasma membrane, tonoplast, and other endomembranes of plant cells. Previous compositional analyses have focused only on individual sphingolipid classes because of the widely differing polarities of plant sphingolipids. Consequently, the total content of sphingolipid classes in plants has yet to be quantified. In addition, the major polar sphingolipid class in the model plant Arabidopsis thaliana has not been previously determined. In this report, we describe the separation and quantification of sphingolipid classes from A. thaliana leaves using hydrolysis of sphingolipids and high performance liquid chromatography (HPLC) analysis of o-phthaldialdehyde derivatives of the released long-chain bases to monitor the separation steps. An extraction solvent that contained substantial proportions of water was used to solubilized >95% of the sphingolipids from leaves. Neutral and charged sphingolipids were then partitioned by anion exchange solid phase extraction. HPLC analysis of the charged lipid fraction from A. thaliana revealed only one major anionic sphingolipid class, which was identified by mass spectrometry as hexose-hexuronic-inositolphosphoceramide. The neutral sphingolipids were predominantly composed of monohexosylceramide with lesser amounts of ceramides. Extraction and separation of sphingolipids from soybean and tomato showed that, like A. thaliana, the neutral sphingolipids consisted of ceramide and monohexosylceramides; however, the major polar sphingolipid was found to be N-acetyl-hexosamine-hexuronic-inositolphosphoceramide. In extracts from A. thaliana leaves, hexosehexuronic-inositolphosphoceramides, monohexosylceramides, and ceramides accounted for approximately 64, 34, and 2% of the total sphingolipids, respectively, suggesting an important role for the anionic sphingolipids in plant membranes.
Control of aggregation in protein refolding: The temperature‐leap tactic (1996)

The kinetics of renaturation of bovine carbonic anhydrase II (CAII) were studied from 4 degrees to 36 degrees, at the relatively high [CAII] of 4 mg/mL. Following dilution to 1 M guanidinium chloride, aggregate formation is very rapid and reduces the formation of active enzyme. The CAII activity yield at 150 min, 20 degrees (approximately 60%), is greater than that at either 4 degrees or 36 degrees. However, if refolding is conducted at 4 degrees, aggregation is reduced dramatically and 37% yield is obtained at 120 min. If the solution is then rapidly warmed to 36 degrees, the yield rises rapidly to 95% at 150 min. This is an example of the "temperature leap" tactic. These results can be understood on the basis of two slow-folding intermediate whose kinetics have been studied. Only the first of these forms aggregates. Kinetic simulations show that, at 4 degrees, the first intermediate is depleted after 120 min, and the second intermediate rapidly isomerizes to active enzyme on warming. A series of experiments was conducted where the initial (120 min) folding temperature was systematically varied, followed by a "leap" to 36 degrees for 30 additional minutes. With initial incubations from 4 degrees to 12 degrees, the final yield is > 90%, drops rapidly from 12 degrees to 20 degrees, and decreases more gradually to approximately 45% at 36 degrees. The overall results qualitatively fit the simple idea of ordinary temperature-accelerated reactions in competition with hydrophobic aggregation, which is strongly suppressed in the cold. Qualifications are discussed for the temperature-leap approach to find application in refolding other proteins.
Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury (1999)

The results demonstrate a strong association between the APOE-epsilon4 allele and a poor clinical outcome, implying genetic susceptibility to the effect of brain injury. Additional studies of TBI patients are warranted to confirm their findings.
Scalable packet classification (2001)

Packet classification is important for applications such as firewalls, intrusion detection, and differentiated services. Existing algorithms for packet classification reported in the literature scale poorly in either time or space as filter databases grow in size. Hardware solutions such as TCAMs do not scale to large classifiers. However, even for large classifiers (say 100,000 rules), any packet is likely to match a few (say 10) rules. Our paper seeks to exploit this observation to produce a scalable packet classification scheme called Aggregated Bit Vector (ABV). Our paper takes the bit vector search algorithm (BV) described in [11] (which takes linear time) and adds two new ideas, recursive aggregation of bit maps and filter rearrangement, to create ABV (which can take logarithmic time for many databases). We show that ABV outperforms BV by an order of magnitude using simulations on both industrial firewall databases and synthetically generated databases.
Abstract C2: Selection for combinational studies through biomarker stratification in colorectal patient-derived explant models. (2011)

Abstract Patient-derived explant models (PTX) show a higher genetic and pathological heterogeneity than cell line derived xenograft models, and may have greater clinical relevance in cancer drug development and personalised oncology treatments than cell line derived xenograft models. Therefore PTX models can potentially be used to provide additional confidence in patient stratification hypotheses for novel therapies or combination approaches. To examine comparative pharmacological responses in PTX models, the monotherapy activity of the MEK inhibitor selumetinib was determined in colorectal cancer PTX models that were stratified according to a MEK pathway “functional activation” mRNA signature, originally derived using a broad human tumor cell line panel (1). Tumor passage, immunohistochemical and genetic markers of target pathway activity were also assessed to collectively select 6 models of high interest for examining response to treatment. In addition, to monotherapy treatment, 3 models were also used to examine the combination of selumetinib with the mTORC1/2 kinase inhibitor AZD8055. The results suggest that the MEK pathway mRNA signature is applicable in colorectal PTX models and enables selumetinib responsive versus non-responsive models to be identified. Combination therapy of selumetinib and AZD8055 has also shown additional therapeutic benefit, similar to that observed in selected cell line derived xenografts. These data illustrate that use of PTX panels can be applied to substantiate in-vitro derived biomarker-led hypotheses for a given therapeutic approach. In addition, biomarker stratification has focused experimental design to test novel:novel combinations and may enable stratification for prospective patient subsets. Collectively this approach to disease modelling could significantly reduce wide screening in vivo studies and steer more refined clinically relevant hypotheses, whilst allowing for a reduction in animal usage. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr C2.
Characterization and mapping of RNase III cleavage sites in VSV genome RNA (1981)

Ribonuclease III cleaves the genome RNA of vesicular stomatitis virus (VSV) to yield an array of fragments which range in size from 3.5 to 0.1 x 10(6) daltons under partial digestion conditions. The locations of the RNase III cleavage sites which give rise to these fragments have been ordered relative to the 3' end of the virion RNA by digestion of 3' end-labeled RNA. Based on a map of the cleavage sites we predicted that fragments having the same size could be generated which contain information from each gene. Annealing of individual VSV mRNA probes to Northern blots of the separated RNase III-generated fragments confirmed that fragments having the same size are, in fact, generated which contain information from each coding region of the VSV genome. Analysis of maps of partial digestion products indicates that fragments having the same size arise repeatedly along the 3' half of the genome. The cleavage of VSV RNA by RNase III can be detected only if the nuclease treated molecules are denatured. This suggest that the structure features in VSV RNA which signal cleavage involve areas of higher order RNA structure.