gebhart/patrepeval huggingface dataset:
Space qualification of IR-reflecting coverslides for GaAs solar cells (1996)

Improvements to GaAs solar array performance, from the use on solar cell coverslides of several reflecting coatings that reject unusable portions of the solar spectrum, are quantified. Blue-red-rejection (BRR) coverslides provide both infrared reflection (IRR) and ultraviolet rejection (UVR). BRR coverslides were compared to conventional antireflection (AR) and ultraviolet (UV) coated coverslides. A 2% improvement in peak-power output, relative to that from Ar-coated coverslides, is seen for cells utilizing BRR coverslides with the widest bandpass. Coverslide BRR-filter bandpass width and covered-solar-cell short-circuit current is a function of incident light angle and the observed narrower-bandpass filters are more sensitive to change in angle from the normal than are wide-bandpass filters. The first long-term (3000 hours) UV testing of unirradiated and 1 MeV electron-irradiated GaAs solar cells, with multilayer-coated coverslides to reduce solar array operating temperature, has indicated that all multilayer coatings on coverslides and solar cells will experience degradation from the space environment (UV and/or electrons). Five types of coverslide coatings, designed for GaAs solar cells, were tested as part of a NASA-sponsored space-flight qualification for BRR, multi-layer-coated, coverslides. The reponse to the different radiations varied with the coatings. The extent of degradation and its consequences on the solar cell electrical characteristics depend upon the coatings and the radiation. In some cases, an improved optical coupling was observed during long-term UV exposure to the optical stack. The benefits of multi-layered solar cell optics may depend upon both the duration and the radiation environment of a mission.
Role of peripheral autonomic neurones in maintaining adequate cardiac function (1995)

This review has focused on the putative effects that peripheral autonomic neurones exert on cardiac myocytes. Through data obtained by the use of in situ and in vitro models, the unique synaptology and chemical sensitivities of the various types of neurones in intrinsic cardiac and extracardiac intrathoracic ganglia are becoming evident. The intrathoracic nervous system acts as a distributive network, processing in a complex fashion information that arises not only from cardiac, vascular and pulmonary tissues but also from extrathoracic tissues, to maintain adequate cardiac function. In challenging the current understanding of cardiac regulation, this view provides novel opportunities to develop pharmacological and surgical strategies to manipulate cardiac function in disease states.
Infusion site soft-tissue injury after paclitaxel administration (1995)

Given the incidence of Grade 2 and Grade 3 local reactions, it appears that paclitaxel should be considered a vesicant.
Can selective digestive decontamination avoid the endotoxemia and cytokine activation promoted by cardiopulmonary bypass? (1993)

Selective digestive decontamination reduces the gut content of enterobacteria, with complete elimination after 3 days of treatment. This fact could explain the lower endotoxin and cytokine concentrations found in the blood samples of patients who had been fully decontaminated. Duration of aortic cross-clamping is an important factor in generating endotoxemia and in the activation of cytokines.
Consensus engineering of sucrose phosphorylase: The outcome reflects the sequence input (2013)

Consensus engineering, which is replacing amino acids by the most frequently occurring one at their positions in a multiple sequence alignment (MSA), is a known strategy to increase the stability of a protein. The application of this concept to the entire sequence of an enzyme, however, has been tried only a few times mainly because of the problems determining the consensus in highly variable regions. We show that this problem can be solved by replacing such problematic regions by the corresponding sequence of the natural homologue closest to the consensus. When one or a few sub-families are overrepresented in the MSA the consensus sequence is a biased representation of the sequence space. We examine the influence of this bias by constructing three consensus sequences using different MSAs of sucrose phosphorylase (SP). Each consensus enzyme contained about 70 mutations compared to its closest natural homologue and folded correctly and displayed activity on sucrose. Correlation analysis revealed that the family's co-evolution network was kept intact, which is one of the main advantages of full-length consensus design. The consensus enzymes displayed an "average" thermostability, that is, one that is higher than some but not all known representatives. We cautiously present practical rules for the design of consensus sequences, but warn that the measure of success depends on which natural enzyme is used as point of comparison.
A Big-Data Perspective on AI: Newton, Merton, and Analytics Intelligence (2012)

The flood of big data in cyberspace will require immediate actions from the AI and intelligent systems community to address how we manage knowledge. Besides new methods and systems, we need a total knowledge-management approach that willl require a new perspective on AI. We need "Merton's systems" in which machine intelligence and human intelligence work in tandem. This should become a normal mode of operation for the next generation of AI and intelligent systems.
Influence of infection route on the infectivity of baculovirus mutants lacking the apoptosis-inhibiting gene p35 and the adjacent gene p94 (1994)

The infectivity of Autographa californica nuclear polyhedrosis virus mutants lacking the apoptosis-inhibiting gene p35 is decreased 1,000-fold or more in larvae of the insect Spodoptera frugiperda if the budded form of the virus is administered by hemocoelic injection; this decrease is correlated with the antiviral effects of apoptosis (R. J. Clem and L. K. Miller, J. Virol. 67:3730-3738, 1993). We have extended this correlation by showing that the infectivity of p35 mutant budded virus is restored to wild-type levels by expression of an unrelated baculovirus apoptosis-inhibiting gene, Cp-iap. We have also examined the oral infectivity of the occluded form of mutants lacking p35, the neighboring p94 gene, or both genes by feeding insects occluded virus. The oral infectivity of the p35 mutant was significantly reduced in S. frugiperda larvae, but this reduction (25-fold) was less than that observed for the hemocoelic route of infection (1,000-fold). The disruption of p94 alone had no apparent effect on infectivity by either route. Unexpectedly, however, the disruption of both p35 and p94 restored oral infectivity to nearly wild-type levels but did not exert this compensatory effect on infectivity by hemocoelic injection. Thus, the infectivity of the double p35/p94 mutant is affected in a route-specific manner in S. frugiperda larvae, suggesting a tissue-specific response to p35 and/or p94. Infectivity in a different host, Trichoplusia ni, was unaffected by all the mutants tested, consistent with previous studies indicating a lack of sensitivity to apoptosis in this species. However, T. ni and S. frugiperda larvae infected with p35 mutants failed to exhibit the symptom of morphological disintegration ("melting") typical of a wild-type infection, suggesting that p35 is required for the infection of some tissues in both species.
Dercitine, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDercitine, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus spGeewananda P. Gunawardana, Shigeo. Kohmoto, Sarath P. Gunasekera, Oliver J. McConnell, and Frank E. KoehnCite this: J. Am. Chem. Soc. 1988, 110, 14, 4856–4858Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00222a071https://doi.org/10.1021/ja00222a071research-articleACS PublicationsRequest reuse permissionsArticle Views382Altmetric-Citations126LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Synthesis of α‐Trifluoromethyl‐Substituted α‐Amino Acids. Part 7. An Efficient Synthesis of α‐Trifluoromethyl‐Substituted ω‐Carboxy α‐Amino Acids. (1990)

Abstract The acylimines (I) of trifluoropyruvate is coupled with the ω‐alkenyl Grignard compounds (II) to produce the N‐protected amino acid esters (III).
Development of the low backlash planetary gearbox for humanoid robots (2017)

The low backlash planetary gearbox as a substitute for a harmonic drive in humanoid robotics, is presented in this paper. After analysis of the contemporary designs of the low backlash coaxial toothed gearboxes, a concept of planetary gearbox with taper gears has been chosen. A synthesis of a planetary mechanism which satisfies the prescribed kinematic-dynamic requirements as well as the design limitations has been performed. Based on the obtained results, parameters necessary for the gearbox design have been defined. The proposed solution has been analysed from various points of view. Analysis results show that the proposed solution has low backlash (<4 arcmin), high coefficient of efficiency (about 97%), four times higher load capacity and five times lower price in comparison with the currently available corresponding harmonic drives. Overall dimensions are nearly the same, while the mass of the planetary gearbox is 10% larger than mass of the corresponding harmonic drive.
Dexmedetomidine Injection during Strabismus Surgery Reduces Emergence Agitation without Increasing the Oculocardiac Reflex in Children: A Randomized Controlled Trial (2016)

Clinical Research Information Service KCT0000141.
A Kinetic Photometric Method for Serum γ-Glutamyl Transpeptidase (1969)

Abstract A kinetic method is described for the determination of γ-glutamyl transpeptidase activity in serum. Optimal conditions for the reaction were ascertained, normal values in milliunits per milliliter at 25° established, and the reliability of the method examined. γ-Glutamyl-p-nitroanilide in ammediol-HCl buffer at pH 8.2 is employed as substrate. The method requires only 0.1 ml. of serum and, using an automatic cuvet positioner and recorder as well as an automatic diluter, more than 60 determinations can be carried out in 1 hr. On the basis of a large number of determinations, the method was shown to be technically excellent and clinically valuable.
Protein-resistant monolayers prepared by hydrosilylation of α-oligo(ethylene glycol)-ω-alkenes on hydrogen-terminated silicon (111) surfaces (2004)

Atomically flat, homogeneous, and protein-resistant monolayers can be readily prepared on H-Si(111) surfaces by photo-induced hydrosilylation of alpha-oligo(ethylene glycol)-omega-alkenes.
Focus (1990)

Essay| February 01 1990 Focus: Notre-Dame De Paris Shelley Rice Shelley Rice Shelley Rice is a New York City historian and critic working on a book about photography and urban planning in Paris during the Second Empire. Search for other works by this author on: This Site PubMed Google Scholar Afterimage (1990) 17 (7): 14–15. https://doi.org/10.1525/aft.1990.17.7.14 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Shelley Rice; Focus: Notre-Dame De Paris. Afterimage 1 February 1990; 17 (7): 14–15. doi: https://doi.org/10.1525/aft.1990.17.7.14 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAfterimage Search This content is only available via PDF. © 1990 by The Regents of the University of California1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Printing of phase-shifting mask defects (1993)

Using both simulations and experimental data, the impact of defect type, size, and location for the three leading phase-shifting techniques, alternate aperture, sized rim shifter, and attenuated, was investigated. Location of the defect was determined to play a major role in the printability of a given defect. Specifically, corner defects located on the inner edge of a rim-shifted pattern posed significant detectability and printability problems. As expected for the vast majority of defects, phase-shifting approaches enhanced the printability of the defect. However, the attenuated approach revealed a unique class of defects that caused much less linewidth deviation than their counterparts on conventional masks. These were the missing chromium/unetched quartz defects. A systematic study of the impact of phase, size, and position for both classes of defects: extra shifter and missing chromium, on an attenuated phase-shifting masks revealed that the design of the attenuated blank was critical in minimizing the impact of defects. Two possible blank configurations were proposed: a partially embedded shifter and a fully embedded configuration. By intelligently selecting the design of the attenuated blank, the impact of defect printability could be reduced.
A Critical Role for the S4-S5 Intracellular Loop in Domain IV of the Sodium Channel α-Subunit in Fast Inactivation (1998)

Na+ channel fast inactivation is thought to involve the closure of an intracellular inactivation gate over the channel pore. Previous studies have implicated the intracellular loop connecting domains III and IV and a critical IFM motif within it as the inactivation gate, but amino acid residues at the intracellular mouth of the pore required for gate closure and binding have not been positively identified. The short intracellular loops connecting the S4 and S5 segments in each domain of the Na+ channel alpha-subunit are good candidates for this role in the Na+ channel inactivation process. In this study, we used scanning mutagenesis to examine the role of the IVS4-S5 region in fast inactivation. Mutations F1651A, near the middle of the loop, and L1660A and N1662A, near the COOH-terminal end, substantially disrupted Na+ channel fast inactivation. The mutant F1651A conducted Na+ currents that decayed very slowly, while L1660A and N1662A had large sustained Na+ currents at the end of 30-ms depolarizing pulses. Inactivation of macroscopic Na+ currents was nearly abolished by the N1662A mutation and the combination of the F1651A/L1660A mutations. Single channel analysis revealed frequent reopenings for all three mutants during 40-ms depolarizing pulses, indicating a substantial impairment of the stability of the inactivated state compared with wild type (WT). The F1651A and N1662A mutants also had increased mean open times relative to WT, indicating a slowed rate of entry into the inactivated state. In addition to these effects on inactivation of open Na+ channels, mutants F1651A, L1660A, and N1662A also impaired fast inactivation of closed Na+ channels, as assessed from measurements of the maximum open probability of single channels. The peptide KIFMK mimics the IFM motif of the inactivation gate and provides a test of the effect of mutations on the hydrophobic interaction of this motif with the inactivation gate receptor. KIFMK restores fast inactivation of open channels to the F1651A/L1660A mutant but does not restore fast inactivation of closed F1651A/L1660A channels, suggesting that these residues interact with the IFM motif during inactivation of closed channels. Our results implicate F1651, L1660, and N1662 of the IVS4-S5 loop in inactivation of both closed and open Na+ channels and suggest that the IFM motif of the inactivation gate interacts with F1651 and/or L1660 in the IVS4-S5 loop during inactivation of closed channels.
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation (2009)

We have quantified the relative contribution of donor antigen-presenting cell populations to alloantigen presentation after bone marrow transplantation (BMT) by using transgenic T cells that can respond to host-derived alloantigen presented within the donor major histocompatibility complex. We also used additional transgenic/knockout donor mice and/or monoclonal antibodies that allowed conditional depletion of conventional dendritic cells (cDCs), plasmacytoid DC (pDCs), macrophages, or B cells. Using these systems, we demonstrate that donor cDCs are the critical population presenting alloantigen after BMT, whereas pDCs and macrophages do not make a significant contribution in isolation. In addition, alloantigen presentation was significantly enhanced in the absence of donor B cells, confirming a regulatory role for these cells early after transplantation. These data have major implications for the design of therapeutic strategies post-BMT, and suggest that cDC depletion and the promotion of B-cell reconstitution may be beneficial tools for the control of alloreactivity.
Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes (2009)

Breast cancers can be divided into subtypes with important implications for prognosis and treatment. We set out to characterize the genetic alterations observed in different breast cancer subtypes and to identify specific candidate genes and pathways associated with subtype biology. mRNA expression levels of estrogen receptor, progesterone receptor, and HER2 were shown to predict marker status determined by immunohistochemistry and to be effective at assigning samples to subtypes. HER2(+) cancers were shown to have the greatest frequency of high-level amplification (independent of the ERBB2 amplicon itself), but triple-negative cancers had the highest overall frequencies of copy gain. Triple-negative cancers also were shown to have more frequent loss of phosphatase and tensin homologue and mutation of RB1, which may contribute to genomic instability. We identified and validated seven regions of copy number alteration associated with different subtypes, and used integrative bioinformatics analysis to identify candidate oncogenes and tumor suppressors, including ERBB2, GRB7, MYST2, PPM1D, CCND1, HDAC2, FOXA1, and RASA1. We tested the candidate oncogene MYST2 and showed that it enhances the anchorage-independent growth of breast cancer cells. The genome-wide and region-specific differences between subtypes suggest the differential activation of oncogenic pathways.
Two Fast Algorithms for Sparse Matrices: Multiplication and Permuted Transposition (1978)

article Free Access Share on Two Fast Algorithms for Sparse Matrices: Multiplication and Permuted Transposition Author: Fred G. Gustavson Mathematical Sciences Department, IBM T.J. Watson Research Center, P.O. Box, 218, Yorktown Heights, NY Mathematical Sciences Department, IBM T.J. Watson Research Center, P.O. Box, 218, Yorktown Heights, NYView Profile Authors Info & Claims ACM Transactions on Mathematical SoftwareVolume 4Issue 3Sept. 1978 pp 250–269https://doi.org/10.1145/355791.355796Published:01 September 1978Publication History 251citation5,639DownloadsMetricsTotal Citations251Total Downloads5,639Last 12 Months809Last 6 weeks334 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Ribosome display selection of a metal‐binding motif from an artificial peptide library (2008)

A new ribosome display system was applied for the in vitro selection of a metal-binding motif from an artificial peptide library. The display system consisted of an mRNA-associating protein, a ribosome, and mRNA. The protein part of this display system was designed to provide a random peptide library and to stabilize the ribosome display. The random peptide library was newly designed to isolate stable metal-binding motifs. We employed the system for in vitro selection and found several new proteins and peptides that bind Co(II)-immobilized resin and Co(II)-complex, respectively. This newly developed system can be conveniently applied to the in vitro selection of peptide aptamers.
Liquid chromatography/mass spectrometry in anabolic steroid analysis—optimization and comparison of three ionization techniques: electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization (2002)

The applicability of liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the detection of the free anabolic steroid fraction in human urine was examined. Electrospray ionization (ESI), atmospheric pressure chemical ionization and atmospheric pressure photoionization methods were optimized regarding eluent composition, ion source parameters and fragmentation. The methods were compared with respect to specificity and detection limit. Although all methods proved suitable, LC/ESI-MS/MS with a methanol-water gradient including 5 mM ammonium acetate and 0.01% acetic acid was found best for the purpose. Multiple reaction monitoring allowed the determination of steroids in urine at low nanogram per milliliter levels. LC/MS/MS exhibited high sensitivity and specificity for the detection of free steroids and may be a suitable technique for screening for the abuse of anabolic steroids in sports.
Homology between nucleotide sequences of promoter regions of nah and sal operons of NAH7 plasmid of Pseudomonas putida. (1986)

The in vivo transcription start sites of the nah and sal operons of the NAH7 plasmid were determined by S1 nuclease mapping and the nucleotide sequence surrounding these transcription start sites was determined. Since expression of both of these operons is coordinately controlled by the product of the transcriptional activator gene nahR, the sequences were compared to locate potential sites involved in common regulation. In the 100-base-pair region preceding transcription start sites of both operons, three regions of extensive homology were found and may be involved in nahR-mediated transcriptional control: between -80 and -60 with 81% homology; between -40 and -28 with 75% homology; between -1 and +15 with 70% homology. Comparison of the promoter sequences of nah and sal with the analogous sequences of the xylABC and xylDEFG operons of the TOL plasmid showed little homology between the 5' regions of these two sets of positively regulated hydrocarbon degradation operons. In addition, the transcription start site of the nahR regulatory gene was located and its promoter sequence was determined. The nahR promoter overlapped at the -35 position of the sal promoter; however, the nahR gene is transcribed in the opposite direction. Sequences similar to the consensus sequences of Escherichia coli promoters (at -35 and -10) were found in nah, sal, and nahR at the appropriate positions.