gebhart/patrepeval huggingface dataset:
A Computerized Risk Index Screening Program for At-Risk Students. (1990)

This paper describes a data-based screening tool for identifying at-risk students. It is intended to complement referral and other qualitative means of identification. The Computerized Risk Index Screening Program (CRISP) is an application of a commonly available data management program that: (1) provides a school-based screening system; (2) can be tailored to local needs and characteristics; (3) is capable of reliably and unobtrusively flagging at-risk students; and (4) could be used by school office staff. In setting up CRISP, the user must identify risk factors to be tracked, determine the criterion or cut-off point for each risk factor, and set a value or weight on each risk factor relative to the other factors. High absence rate, low grades, and poor conduct are included as standard risk factors, but any factor for which data are quantifiable and readily accessible to the school may be added. The computer program: (1) produces an index score for each student listed; (2) calculates totals and averages for each risk factor; (3) allows the user to sort (rank order) the data by risk factor; (4) can provide a variety of statisUcal calculations; and (5) can provide several types of printed reports. Field testing of CRISP is under way. In a preliminary tryout, CRISP selected 15 of 16 students previously identified by teachers as being at risk in a class of 34 kindergartners. A sample screening and tracking worksheet is included. (SV) *************************1********************************************* Reproductions supplied by EDRS are the best that can be made from the original document. *********************************************************************** A COMPUTERIZED RISK INDEX SCREENING PROGRAM FOR AT-RISK STUDENTS Joseph J. Stowitschek James T.H. Buiteel Linda S. Pepier Albert J. Smith
Synthesis and Structure−Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor Agonists (2006)

A series of potent neuronal nicotinic acetylcholine receptor (nAChR) ligands based on a 3,8-diazabicyclo[4.2.0]octane core have been synthesized and evaluated for affinity and agonist efficacy at the human high affinity nicotine recognition site (halpha4beta2) and in a rat model of persistent nociceptive pain (formalin model). Numerous analogs in this series exhibit picomolar affinity in radioligand binding assays and nanomolar agonist potency in functional assays, placing them among the most potent nAChR ligands known for the halpha4beta2 receptor. Several of the compounds reported in this study (i.e., 24, 25, 28, 30, 32, and 47) exhibit equivalent or greater affinity for the halpha4beta2 receptor relative to epibatidine, and like epibatidine, many exhibit robust analgesic efficacy in the rat formalin model of persistent pain.
Senescent Cells and Their Secretory Phenotype as Targets for Cancer Therapy (2013)

Cancer is a devastating disease that increases exponentially with age. Cancer arises from cells that proliferate in an unregulated manner, an attribute that is countered by cellular senescence. Cellular senescence is a potent tumor-suppressive process that halts the proliferation, essentially irreversibly, of cells at risk for malignant transformation. A number of anti-cancer drugs have emerged that induce tumor cells to undergo cellular senescence. However, although a senescence response can halt the proliferation of cancer cells, the presence of senescent cells in tissues has been associated with age-related diseases, including, ironically, late-life cancer. Thus, anti-cancer therapies that can induce senescence might also drive aging phenotypes and age-related pathology. The deleterious effects of senescent cells most likely derive from their senescence-associated secretory phenotype or SASP. The SASP entails the secretion of numerous inflammatory cytokines, growth factors and proteases that can render the tissue microenvironment favorable for tumor growth. Here, we discuss the beneficial and detrimental effects of inducing cellular senescence, and propose strategies for targeting senescent cells as a means to fight cancer.
Relationship of vaginal microflora to PROM, pPROM and the risk of early-onset neonatal sepsis. (2008)

Based on results of the present study, it is clear that the use of cultivation and microscopic findings in the vagina and cervix for the timely diagnosis of the risk of early-onset neonatal sepsis is restricted.
Involvement of lipid peroxidation in CNS injury. (1992)

The generation of oxygen radicals and the process of lipid peroxidation have become a focus of attention for investigators in the fields of central nervous system (CNS) injury and stroke (e.g., ischemia). While absolute proof for their involvement in the pathophysiology of traumatic and ischemic damage to the CNS remains to be established, numerous recent studies have provided considerable support for the occurrence of free radical and lipid peroxidation reactions in the injured or ischemic CNS. Furthermore, the use of antioxidants and free radical scavengers in the treatment of experimental and clinical CNS trauma and ischemia has provided convincing support for the involvement of oxygen radicals and lipid peroxidation in these conditions. In this report we will review some of the history behind the hypothesis for an involvement of oxygen radical-mediated lipid peroxidation in the pathophysiology of CNS injury and look at some of the more recent work conducted in this area.
Imiquimod Treatment Induces Expression of Opioid Growth Factor Receptor (2004)

In addition to its immunomodulatory and antiproliferative activity, opioid growth factor receptor seems to have a prognostic significance in basal cell carcinoma patients. Our data add to the growing list of basal cell carcinoma-associated tumor antigens.
High-Affinity HLA-A(*)02.01 Peptides from Parathyroid Hormone-Related Protein Generate In Vitro and In Vivo Antitumor CTL Response Without Autoimmune Side Effects (2002)

Parathyroid hormone-related protein (PTH-rP), a protein produced by prostate carcinoma and other epithelial cancers, is a key agent in the development of bone metastases. We investigated whether the protein follows the self-tolerance paradigm or can be used as a target Ag for anticancer immunotherapy by investigating the immunogenicity of two HLA-A(*)02.01-binding PTH-rP-derived peptides (PTR-2 and -4) with different affinity qualities. PTH-rP peptide-specific CTL lines were generated from the PBMC of two HLA-A(*)02.01(+) healthy individuals, stimulated in vitro with PTH-rP peptide-loaded autologous dendritic cells and IL-2. The peptide-specific CTLs were able to kill PTH-rP(+)HLA-A(*)02.01(+) breast and prostate carcinoma cell lines. The two peptides were also able to elicit a strong antitumor PTH-rP-specific CTL response in HLA-A(*)02.01 (HHD) transgenic mice. The vaccinated mice did not show any sign of side effects due to cell-mediated autoimmunity or toxicity. In this study we describe two immunogenic and toxic-free PTH-rP peptides as valid candidates for the design of peptide-based vaccination strategies against prostate cancer and bone metastases from the most common epithelial malignancies.
Multiple kernel tracking with SSD (2004)

Kernel-based objective functions optimized using the mean shift algorithm have been demonstrated as an effective means of tracking in video sequences. The resulting algorithms combine the robustness and invariance properties afforded by traditional density-based measures of image similarity, while connecting these techniques to continuous optimization algorithms. This paper demonstrates a connection between kernel-based algorithms and more traditional template tracking methods. here is a well known equivalence between the kernel-based objective function and an SSD-like measure on kernel-modulated histograms. It is shown that under suitable conditions, the SSD-like measure can be optimized using Newton-style iterations. This method of optimization is more efficient (requires fewer steps to converge) than mean shift and makes fewer assumptions on the form of the underlying kernel structure. In addition, the methods naturally extend to objective functions optimizing more elaborate parametric motion models based on multiple spatially distributed kernels. We demonstrate multi-kernel methods on a variety of examples ranging from tracking of unstructured objects in image sequences to stereo tracking of structured objects to compute full 3D spatial location.
All-trans retinoic acid enhances temozolomide-induced autophagy in human glioma cells U251 via targeting Keap1/Nrf2/ARE signaling pathway (2017)

The present study evaluated the retinoic acid (RA) enhancement of temozolomide (TMZ) effects on the human glioma cells U251 and explored its underlying molecular mechanism. The cell growth was detected using the MTT assay and the cell cycle was assessed by flow cytometry. Cell apoptosis was analyzed by Annexin V/propidium iodide staining, and the cell morphology was evaluated using transmission electron microscopy (TEM). Additionally, reverse transcription-PCR and western blot analysis were applied to detect the mRNA and protein levels. The RA treatment in combination with TMZ in the human U251 cells further inhibited cells growth, arresting cell cycle progression at the G0/G1 phase, and significantly induced apoptosis of U251 cells. After the RA+TMZ treatment of U251 cells, autophagy associated proteins Beclin 1 and LC3B were significantly increased, and the TEM analysis were consistent with autophagy protein levels. Moreover, Keap1/Nrf2/ARE expression was downregulated significantly, indicating the involvement in the mechanisms that RA treatment could enhance the TMZ effects on U251 cells. RA treatment in combination with TMZ may provide some experimental evidence for the possible effect of RA+TMZ against the growth and the proliferation of glioma cells. Therefore, the RA+TMZ administration may have potential utility for glioblastoma treatment.
Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen. (2006)

Yersinia pestis, the causative agent of bubonic and pneumonic plagues, has undergone detailed study at the molecular level. To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516. The genomes of Antiqua and Nepal516 are 4.7 Mb and 4.5 Mb and encode 4,138 and 3,956 open reading frames, respectively. Though both strains belong to one of the three classical biovars, they represent separate lineages defined by recent phylogenetic studies. We compare all five currently sequenced Y. pestis genomes and the corresponding features in Yersinia pseudotuberculosis. There are strain-specific rearrangements, insertions, deletions, single nucleotide polymorphisms, and a unique distribution of insertion sequences. We found 453 single nucleotide polymorphisms in protein-coding regions, which were used to assess the evolutionary relationships of these Y. pestis strains. Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. The results presented here clearly demonstrate the differences between the two biovar antiqua lineages and support the notion that grouping Y. pestis strains based strictly on the classical definition of biovars (predicated upon two biochemical assays) does not accurately reflect the phylogenetic relationships within this species. A comparison of four virulent Y. pestis strains with the human-avirulent strain 91001 provides further insight into the genetic basis of virulence to humans.
Toward Simulation-Based Optimization in Data Stream Management Systems (2008)

Our demonstration introduces a novel system architecture which massively facilitates optimization in data stream management systems (DSMS). The basic idea is to decouple optimization from the operative system by means of a secondary optimization system, which bears the burden of determining new query plans. Within the secondary system, which typically runs on a separate machine, we utilize suitable statistical models of the original data streams to simulate them. As the simulation can run at much faster rates, we are able to examine and assess new query plans in a shorter period of time without running the risk of deteriorating the original plan; we only migrate practically approved plans into the operative system. In our demonstration, we will present our prototypical implementation of this optimization architecture. We will demonstrate the interaction between primary and secondary system as well as the key features of the whole optimization process.
Virus Filtration Membranes Prepared from Nanoporous Block Copolymers with Good Dimensional Stability under High Pressures and Excellent Solvent Resistance (2008)

Abstract We introduce a nanoporous membrane suitable for virus filtration with good dimensional stability under high pressures maintaining high selectivity. The membrane consists of a double layer: The upper layer is a nanoporous film with pore size of ∼17 nm and a thickness of ∼160 nm, which was prepared by polystyrene‐ block ‐poly(methyl methacrylate) copolymer (PS‐ b ‐PMMA) where PMMA block was removed by ultraviolet irradiation followed by rinsing with acetic acid. The nanoporous block copolymer film was combined with a conventional micro‐filtration membrane to enhance mechanical strength. The membrane employed in this study did not show any damage or crack even at a pressure of 2 bar, while high selectivity was maintained for the filtration of human rhinovirus type 14 which has a diameter of ∼30 nm and is a major pathogen of the common cold in humans. Furthermore, due to crosslinked PS matrix during the UV irradiation, the nanoporous membrane showed excellent resistance to all organic solvents. This could be used under harsh filtration conditions such as high temperature and strong acidic (or basic) solution.
Significant Conductivity Enhancement of Conductive Poly(3,4-ethylenedioxythiophene): Poly(styrenesulfonate) Films through a Treatment with Organic Carboxylic Acids and Inorganic Acids (2010)

Significant conductivity enhancement was observed on transparent and conductive poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) films after a treatment with organic and inorganic acids, including acetic acid, propionic acid, butyric acid, oxalic acid, sulfurous acid, and hydrochloric acid. The conductivity could be enhanced from 0.2 to over 200 S cm(-1), that is, by a factor of more than 1000. The conductivity enhancement was dependent on the structure of the acids and the experimental conditions during the treatment, such as the acid concentration and the temperature. The optimal temperature was in the range of 120 to 160 degrees C. The resistance dropped rapidly when a PEDOT:PSS film was treated with acid solution of high concentration, whereas it gradually increased and then decreased when it was treated with an acid solution of low concentration. The mechanism for this conductivity enhancement was studied by various chemical and physical characterizations. The temperature dependence of conductivity indicates that the energy barrier for charge hopping among the PEDOT chains become lower in the highly conductive PEDOT:PSS film after the acid treatment. The ultraviolet-visible-near-infrared (UV-vis-NIR) absorption spectroscopy, the X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) indicate the loss of polystyrene sulfonic acid (PSSH) chains from the PEDOT:PSS film after the acid treatment, and the atomic force microscopy (AFM) suggest conformational change of the polymer chains. Therefore, the conductivity enhancement is attributed to the loss of PSSH chains from the PEDOT:PSS film and the conformational change of the PEDOT chains, which are induced by the acids.
Predictors of Cognitive Dysfunction after Major Noncardiac Surgery (2008)

Cognitive dysfunction is common in adult patients of all ages at hospital discharge after major noncardiac surgery, but only the elderly (aged 60 yr or older) are at significant risk for long-term cognitive problems. Patients with POCD are at an increased risk of death in the first year after surgery.
Low-Cost Inorganic Solar Cells: From Ink To Printed Device (2010)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTLow-Cost Inorganic Solar Cells: From Ink To Printed DeviceSusan E. Habas, Heather A. S. Platt, Maikel F. A. M. van Hest, and David S. Ginley*View Author Information National Renewable Energy Laboratory, 1617 Cole Boulevard, Golden, Colorado 80401, United States* To whom correspondence should be addressed. E-mail: [email protected]Cite this: Chem. Rev. 2010, 110, 11, 6571–6594Publication Date (Web):October 25, 2010Publication History Received21 June 2010Published online25 October 2010Published inissue 10 November 2010https://pubs.acs.org/doi/10.1021/cr100191dhttps://doi.org/10.1021/cr100191dreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views16270Altmetric-Citations407LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Deposition,Materials,Metals,Oxides,Thin films Get e-Alerts
Characterization of β-lactams by photodissociation and collision-activated dissociation in a quadrupole ion trap (1998)

Electrospray ionization was used to introduce β-lactams, including cephalosporin and penicillin analogs, into a quadrupole ion trap for analysis by collision-activated dissociation (CAD) and infrared multiphoton dissociation (IRMPD). The two dissociation methods provided similar spectra; however, photodissociation requires substantially less tuning than is typically required to optimize CAD. Moreover, IRMPD was effective even at the elevated pressures introduced by the electrospray source. Both CAD and IRMPD promote cleavage across the β-lactam ring, resulting in highly diagnostic fragmentation patterns. Time-resolved and SWIFT methods were used to determine fragmentation genealogies of the ions created by IRMPD. © 1998 John Wiley & Sons, Ltd.
In Vivo Stimulation of De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin (2007)

Injection of cross-linked hyaluronic acid stimulates collagen synthesis, partially restoring dermal matrix components that are lost in photodamaged skin. We hypothesize that this stimulatory effect may be induced by mechanical stretching of the dermis, which in turn leads to stretching and activation of dermal fibroblasts. These findings imply that cross-linked hyaluronic acid may be useful for stimulating collagen production therapeutically, particularly in the setting of atrophic skin conditions.
CK1α Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability (2009)

The ubiquitin ligase murine double minute clone 2 (MDM2) mediates ubiquitination and degradation of the tumor suppressor p53. The activation and stabilization of p53 by contrast is maintained by enzymes catalyzing p53 phosphorylation and acetylation. Casein kinase 1 (CK1) is one such enzyme; it stimulates p53 after transforming growth factor-beta treatment, irradiation, or DNA virus infection. We analyzed whether CK1 regulates p53 protein stability in unstressed conditions. Depletion of CK1 using small interfering RNA or inhibition of CK1 using the kinase inhibitor (D4476) activated p53 and destabilized E2F-1, indicating that steady-state levels of these proteins are controlled by CK1. Co-immunoprecipitation of endogenous CK1 with MDM2 occurred in undamaged cells, indicating the existence of a stable multiprotein complex, and as such, we evaluated whether the MDM2 Nutlin had similar pharmacological properties to the CK1 inhibitor D4476. Indeed, D4476 or Nutlin treatments resulted in the same p53 and E2F-1 steady-state protein level changes, indicating that the MDM2 x CK1 complex is both a negative regulator of p53 and a positive regulator of E2F-1 in undamaged cells. Although the treatment of cells with D4476 resulted in a partial p53-dependent growth arrest, the induction of p53-independent apoptosis by D4476 suggested a critical role for the MDM2 x CK1 complex in maintaining E2F-1 anti-apoptotic signaling. These data highlighting a pharmacological similarity between MDM2 and CK1 small molecule inhibitors and the fact that CK1 and MDM2 form a stable complex suggest that the MDM2 x CK1 complex is a component of a genetic pathway that co-regulates the stability of the p53 and E2F-1 transcription factors.
Beyond Pay for Performance — Emerging Models of Provider-Payment Reform (2008)

Escalating costs and the growing imbalance between primary and specialty care have increased the urgency of calls for fundamental reform of the health care payment system. At the core of the problem is the fact that the dominant fee-for-service model rewards volume and intensity rather than value. But although the faults in the way we currently pay for health care are obvious, it is much less clear what feasible approach would yield better results.Earlier this decade, pay for performance took center stage as a tactic for realigning payment with value. Payers' experiences during this period, as well as several . . .
The effect of inhaled sodium cromoglycate on cellular infiltration into the bronchial mucosa and the expression of adhesion molecules in asthmatics (1997)

There is no direct evidence of the anti-inflammatory effect of inhaled sodium cromoglycate (SCG). To investigate whether inhaled SCG has any effect on cellular infiltration into the bronchial mucosa and the expression of adhesion molecules in patients with asthma, biopsies of the bronchial mucosa were taken from nine patients with atopic bronchial asthma before and after treatment with inhaled SCG (8 mg x day(-1)) from a metered-dose inhaler (MDI). Eosinophils were stained with anti-EG2, neutrophils with anti-NP57, mast cells with anti-AA1, T-lymphocytes with anti-CD4, CD8 and CD3, and macrophages with anti-CD68. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and P-selectin were stained at the same time as adhesion molecules expressed in vascular endothelium. The intensity of ICAM-1 expression in the bronchial epithelium was also evaluated. The numbers of eosinophils, mast cells, T-lymphocytes and macrophages were significantly reduced as a result of SCG administration, and the expression of ICAM-1, VCAM-1 and ELAM-1 was also significantly inhibited. A significant correlation was found between ICAM-1 expression and T-lymphocytes and between VCAM-1 expression and eosinophils. It was concluded that sodium cromoglycate does have an effect on the infiltration of the bronchial mucosa by inflammatory cells and also on the expression of adhesion molecules.