gebhart/patrepeval huggingface dataset:
Filling holes in 3D scanned model base on 2D image inpainting (2017)

Nowadays 3D model scanning is widely used for many purpose. Although scanning technique had become much advanced then earliest, users may still obtain damaged model due to unfamiliar with scanning technique, then we need to repair the model by doing hole-filling and surface reconstruction. In this paper we introduce an approach to fill holes in 3D mesh by using 2D Image Inpainting technique. We create image of depth value to represent depth information and image of color to represent color of surfaces, then inpaint those images and use result images to reconstruct holes of model. The advantage of using Image Inpainting is the flexibility of using image inpainting method, we can use different inpainting method for different purpose. We obtain color and depth image by doing 3D projection and find holes in model by doing hole detection, then we inpaint these images and do 2D to 3D transformation of new added pixels back to 3D space. This work can use any inpaint algorithm without modification. In this paper we use both structural inpainting and textural inpainting, structural inpainting is used for reconstructing depth values and textural inpainting is used for reconstructing texture of surface. The results of our experiment proves that our approach is suitable for model that has uncomplicated structure and texture on the surface.
Effects of recombinant granulocyte colony-stimulating factor (rG-CSF) and recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) on acute radiation hematopoietic injury in mice. (1989)

We have attempted to evaluate in vivo effects of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) on acute radiation hematopoietic injury in mice. BDF1 mice, irradiated with 7.5-Gy x-rays, were injected i.p. twice daily for 10 days with 10(5) U recombinant human G-CSF, 3.75 x 10(5) U recombinant murine GM-CSF, or a combination of both. G-CSF significantly enhanced the recovery of not only peripheral leukocytes but also platelets and hematocrit on days 14 and 21 after irradiation. GM-CSF significantly enhanced the recovery of platelets on day 14 and peripheral leukocytes on day 21. G-CSF markedly enhanced the recovery of spleen colony-forming units (CFU-S), colony-forming units in culture (CFU-C), erythroid burst-forming units (BFU-E), and megakaryocyte colony-forming units (CFU-Meg) both in bone marrow and in the spleen. GM-CSF significantly enhanced the recovery of CFU-Meg in bone marrow on day 14. We found synergistic effects between G-CSF and GM-CSF on CFU-S, CFU-C, and CFU-Meg in the spleen on day 14, although we found antagonistic effects between G-CSF and GM-CSF on CFU-S and CFU-C in bone marrow on day 7, and on platelet counts on day 7. These results indicate that the administration of recombinant G-CSF and GM-CSF may be useful in accelerating hematopoietic recovery in patients with acute radiation hematopoietic injuries.
Dynamic optimization for efficient strong atomicity (2008)

Transactional memory (TM) is a promising concurrency control alternative to locks. Recent work has highlighted important memory model issues regarding TM semantics and exposed problems in existing TM implementations. For safe, managed languages such as Java, there is a growing consensus towards strong atomicity semantics as a sound, scalable solution. Strong atomicity has presented a challenge to implement efficiently because it requires instrumentation of non-transactional memory accesses, incurring significant overhead even when a program makes minimal or no use of transactions. To minimize overhead, existing solutions require either a sophisticated type system, specialized hardware, or static whole-program analysis. These techniques do not translate easily into a production setting on existing hardware. In this paper, we present novel dynamic optimizations that significantly reduce strong atomicity overheads and make strong atomicity practical for dynamic language environments. We introduce analyses that optimistically track which non-transactional memory accesses can avoid strong atomicity instrumentation, and we describe a lightweight speculation and recovery mechanism that applies these analyses to generate speculatively-optimized but safe code for strong atomicity in a dynamically-loaded environment. We show how to implement these mechanisms efficiently by leveraging existing dynamic optimization infrastructure in a Java system. Measurements on a set of transactional and non-transactional Java workloads demonstrate that our techniques substantially reduce the overhead of strong atomicity from a factor of 5x down to 10% or less over an efficient weak atomicity baseline.
Effect of trehalose on protein structure (2008)

Trehalose is a ubiquitous molecule that occurs in lower and higher life forms but not in mammals. Till about 40 years ago, trehalose was visualized as a storage molecule, aiding the release of glucose for carrying out cellular functions. This perception has now changed dramatically. The role of trehalose has expanded, and this molecule has now been implicated in a variety of situations. Trehalose is synthesized as a stress-responsive factor when cells are exposed to environmental stresses like heat, cold, oxidation, desiccation, and so forth. When unicellular organisms are exposed to stress, they adapt by synthesizing huge amounts of trehalose, which helps them in retaining cellular integrity. This is thought to occur by prevention of denaturation of proteins by trehalose, which would otherwise degrade under stress. This explanation may be rational, since recently, trehalose has been shown to slow down the rate of polyglutamine-mediated protein aggregation and the resultant pathogenesis by stabilizing an aggregation-prone model protein. In recent years, trehalose has also proved useful in the cryopreservation of sperm and stem cells and in the development of a highly reliable organ preservation solution. This review aims to highlight the changing perception of the role of trehalose over the last 10 years and to propose common mechanisms that may be involved in all the myriad ways in which trehalose stabilizes protein structures. These will take into account the structure of trehalose molecule and its interactions with its environment, and the explanations will focus on the role of trehalose in preventing protein denaturation.
Chemical tuning of the electronic properties of poly(p-phenylenevinylene)-based copolymers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical tuning of the electronic properties of poly(p-phenylenevinylene)-based copolymersPaul L. Burn, Arno Kraft, Derek Baigent R., Donal D. C. Bradley, Adam R. Brown, Richard H. Friend, Richard W. Gymer, Andrew B. Holmes, and Roger W. JacksonCite this: J. Am. Chem. Soc. 1993, 115, 22, 10117–10124Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00075a030https://doi.org/10.1021/ja00075a030research-articleACS PublicationsRequest reuse permissionsArticle Views940Altmetric-Citations216LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Synthesis and reactions of substituted furo[3,2-b]pyrrole derivatives (1981)

Preparation of ethyl 2-methylfuro[3,2- b ]pyrrole-5-carboxylate and 2-bromofuro[3,2- b ]pyrrole-5-carboxylate, as well as alkylation and hydrolysis of ethyl 2-methylfuro[3,2- b ]pyrrole-5-carboxylate, ethyl furo[3,2- b ]pyrrole-5-carboxylate and ethyl (3,4-dichlorophenyl)furo[3,2- b ]pyrrole-5-carboxylate, is described. IR, UV, 1 H NMR, 13 C NMR and mass spectra of the synthesized compounds were measured and interpreted.
An Erythroid Differentiation Signature Predicts Response to Lenalidomide in Myelodysplastic Syndrome (2008)

These studies indicate that lenalidomide-responsive patients have a defect in erythroid differentiation, and suggest a strategy for a clinical test to predict patients most likely to respond to the drug. The experiments further suggest that the efficacy of lenalidomide, whose mechanism of action in MDS is unknown, may be due to its ability to induce erythroid differentiation.
The Application of Enzyme Immunoassay to the Study of Salivary IGA (1982)

In the study of salivary IgA, solid-phase enzyme immunoassay has been able to show that 1) the assay is reliable, 2) minimal loss of IgA occurs from centrifuging or by elimination of insoluble mucins, 3) IgA can be easily measured in fractions from sucrose gradient sedimentation, 4) freezing alone is sufficient to preserve salivary IgA, 5) the concentration in normal saliva in 11 persons ranged from 15 to 240 mg/L (-/x = 81), and 6) an abnormal saliva contained less than 6 ug/L, the detection limit for this EIA.
Abstract SY28-02: Tumor targeting with antimitotic monoclonal antibody drug conjugates. (2013)

Abstract Monoclonal antibodies (mAbs) have played a major role in cancer medicine, with active drugs such as trastuzumab, cetuximab, bevacizumab and rituximab in a wide range of therapeutic applications. The mechanism of activity of these agents involves cell signaling, effector functions through interactions with Fcγ receptor positive cells, and complement fixation. The activity of mAbs can be enhanced through the generation of antibody drug conjugates (ADCs) that are capable of delivering cytotoxic agents with some degree of selectivity to tumor cells. Early work in this field involved the use of clinically approved anticancer drugs that generally were low in potency. Consequently, the resulting ADCs had suboptimal activities. Because of this, significant attention was directed towards the identification of appropriate drugs for targeted delivery, the most successful being antimitotic drugs such as monomethyl auristatin E (MMAE), and maytansinoids. These drugs inhibit tubulin polymerization and arrest cell growth in a cell-cycle dependent manner. Successful delivery of these agents requires drug, linker, and conjugation optimization, in addition to judicious selection of an antigen target on tumor cell surfaces. Brentuximab vedotin, a conjugate comprised of the anti-CD30 mAb cAC10 conjugated with MMAE through a highly stable peptide linker, is an example of how addressing these considerations can lead to ADCs with pronounced clinical efficacy. In August 2011, brentuximab vedotin received accelerated approval by the US Food and Drug Administration for use in relapsed or refractory Hodgkin lymphoma and relapsed or refractory systemic anaplastic large cell lymphoma, two diseases with significant unmet medical needs. An overview of how this targeted antimitotic drug was developed and how we are extending the technology will be provided. Citation Format: Peter Senter. Tumor targeting with antimitotic monoclonal antibody drug conjugates. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr SY28-02. doi:10.1158/1538-7445.AM2013-SY28-02
Clearance Properties of Nano-Sized Particles and Molecules as Imaging Agents: Considerations and Caveats (2008)

Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities. Yet, some of the most promising nanoparticles demonstrate prolonged tissue retention and contain heavy metals. This presents serious concerns for toxicity. The creation of nanoparticles with optimal clearance characteristics will minimize toxicity risks by reducing the duration of exposure to these agents. Given that many nanoparticles possess easily modifiable surface and interior chemistry, if nanoparticle characteristics associated with optimal clearance from the body were well established, it would be feasible to design and create agents with more favorable clearance properties. This article presents a thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, and provides an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules, including dendrimers, quantum dots, liposomes and carbon, gold and silica-based nanoparticles.
Online interaction: negotiation of meaning and strategies used among learners of Spanish (2001)

Online interactive exchange offers learners many opportunities to use the target language to negotiate both meaning and form in a social context that is crucial for second language acquisition (SLA). This paper discusses the interaction between non-native speakers (NNSs) and the types of communication strategies employed during the online communication. A total of forty students participated in online discussions using a private chatroom. Data from this study suggest that interactive strategies facilitate comprehension of input and output. The results show that regardless of proficiency level, students used a variety of communication strategies. However, students tended to use more comprehension checks, clarification checks, requests and self-repairs to negotiate with each other. The quick interactions taking place in cyberspace impeded students from producing correct and coherent discourse, especially during the learner-learner interaction. Pedagogically, students need to be advised of the need to write correctly to maintain a balance between function, content, and accuracy. One of the corrective techniques is to make students re-examine and revise their exchanges with guided instruction. The current study focused on online interaction among NNSs. To claim the effectiveness of online interaction in SLA with certainty, future studies on online negotiation must include both NNSs and native speakers.
Tunable fabrication of three-dimensional polyamide-66 nano-fiber/nets for high efficiency fine particulate filtration (2011)

A novel airborne particulate filtration medium, consisting of a two-tier composite structure, i.e., a nano-fiber/net (NFN) top layer and a conventional nonwoven microfibrous support, was demonstrated for highly efficient and low pressure drop filtration for the first time. The polyamide-66 (PA-66) NFN structured top layer, which is composed of traditional electrospun nanofibers and two-dimensional (2D) spider-web-like nano-nets, was electro-spinning/netting (ESN) deposited on the nonwoven polypropylene (PP) scaffold for constructing this new concept of filter. The morphology of NFN architecture, including fiber diameter, coverage rate, pore-width and layer-by-layer packing structure of the nano-nets, can be finely controlled by regulating the solution properties and several ESN process parameters. Taking advantage of several fascinating features such as extremely small diameter, high porosity, controllable coverage rate, nano-nets bring to the NFN/nonwoven composite filtration medium several excellent filtration features such as high filtration efficiency (up to 99.9%), low pressure drop, facile filters cleaning, and more lightweight.
TMPZnCl·LiCl: A New Active Selective Base for the Directed Zincation of Sensitive Aromatics and Heteroaromatics (2009)

A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using TMPZnCl.LiCl, a new exceptionally mild and efficient base. Activated arenes and heteroarenes are metalated at room temperature. Remarkably, sensitive functions such as an aldehyde as well as a nitro group are tolerated, expanding significantly the scope of directed metalations.
Identification and characterization of a previously undescribed cyt gene in Bacillus thuringiensis subsp. israelensis (1997)

Mosquitocidal Bacillus thuringiensis strains show as a common feature the presence of toxic proteins with cytolytic and hemolytic activities, Cyt1Aa1 being the characteristic cytolytic toxin of Bacillus thuringiensis subsp. israelensis. We have detected the presence of another cyt gene in this subspecies, highly homologous to cyt2An1, coding for the 29-kDa cytolytic toxin from B. thuringiensis subsp. kyushuensis. This gene, designated cyt2Ba1, maps upstream of cry4B coding for the 130-kDa crystal toxin, on the 72-MDa plasmid of strain 4Q2-72. Sequence analysis revealed, as a remarkable feature, a 5' mRNA stabilizing region similar to those described for some cry genes. PCR amplification and Southern analysis confirmed the presence of this gene in other mosquitocidal subspecies. Interestingly, anticoleopteran B. thuringiensis subsp. tenebrionis belonging to the morrisoni serovar also showed this gene. On the other hand, negative results were obtained with the anti-lepidopteran strains B. thuringiensis subsp. kurstaki HD-1 and subsp. aizawai HD-137. Western analysis failed to reveal Cyt2A-related polypeptides in B. thuringiensis subsp. israelensis 4Q2-72. However, B. thuringiensis subsp. israelensis 1884 and B. thuringiensis subsp. tenebrionis did show cross-reactive products, although in very small amounts.
Cadherins and Langerhans cell immunobiology. (1997)

Langerhans cells represent the epidermal contingent of a family of potent accessory cells termed 'dendritic cells'. Langerhans cells (and perhaps related cells in the dermis) are thought to be required for immune responses directed against foreign antigens and neoantigens that are encountered in skin. The 'life cycle' of the Langerhans cell is characterized by at least two distinct stages. Langerhans cells in epidermis (the 'sentinels') can ingest particulates and process antigens efficiently, but are weak stimulators of unprimed T cells. In contrast, Langerhans cells that have been induced to migrate to lymph nodes after contact with antigen in epidermis (the 'messengers') are not phagocytic and have limited antigen-processing capabilities, but are potent stimulators of naïve T cells. If Langerhans cells are to fulfil both their 'sentinel' and 'messenger' roles, they must be able to persist in epidermis for considerable periods, and also be able to exit epidermis in a controlled fashion after exposure to antigen. Thus, regulation of Langerhans cell-keratinocyte adhesion represents a key control point in Langerhans cell trafficking and function. Langerhans cells express E-cadherin, a homophilic adhesion molecule that is prominently represented in epithelia. Keratinocytes also express this adhesion molecule, and E-cadherin clearly mediates adhesion of murine Langerhans cells to keratinocytes in vitro. We presume that E-cadherin is involved in the localization of Langerhans cells in epidermis. Murine thymocytes also express E-cadherin early in the course of their development, and it is likely that E-cadherin plays an as yet uncharacterized role in thymocyte-thymic epithelial cell adhesion and in T-cell development. Recently, it has also been demonstrated that some cutaneous T-cell lymphoma cell lines are E-cadherin+, so E-cadherin may also mediate clinically important leucocyte-epithelial interactions in disease states.
Graphite furnace atomic absorption spectroscopic measurement of blood lead in matrix-matched standards (1994)

Now that the level of concern for a toxic blood lead concentration is 0.482 mumol/L (10 micrograms/dL), laboratories must meet new requirements to shorten analysis times and increase accuracy and precision of blood lead determinations. We used a matrix-matching method to estimate the lead concentration in blood by graphite furnace atomic absorption spectroscopy (GFAAS). For CDC proficiency samples and the NIST-Certified Blood Reference standard, the performance of this method compared favorably with that of previously published GFAAS methods and of the anodic stripping voltammetric method routinely used in our laboratory. At lead concentrations of 0.242 mumol/L (5.01 micrograms/dL) and 1.478 mumol/L (30.63 micrograms/dL), within-run CVs were 2.78% and 0.68%, respectively; between-run CVs were 4.9% and 1.35%. In 52 study samples with lead content ranging from 0.097 to 3.812 mumol/L (2 to 79 micrograms/dL), 87% of results by the matrix-modified method were within 0.048 mumol/L (1 microgram/dL) of consensus values.
Estrogen Receptor Mutations Found in Breast Cancer Metastases Integrated With the Molecular Pharmacology of Selective ER Modulators (2015)

The consistent reports of mutations at Asp538 and Tyr537 in helix 12 of the ligand-binding domain (LBD) of estrogen receptors (ERs) from antihormone-resistant breast cancer metastases constitute an important advance. The mutant amino acids interact with an anchor amino acid, Asp351, to close the LBD, thereby creating a ligand-free constitutively activated ER. Amino acids Asp 538, Tyr 537, and Asp 351 are known to play a role in either the turnover of ER, the antiestrogenic activity of the ER complex, or the estrogen-like actions of selective ER modulators. A unifying mechanism of action for these amino acids to enhance ER gene activation and growth response is presented. There is a range of mutations described in metastases vs low to zero in primary disease, so the new knowledge is of clinical relevance, thereby confirming an additional mechanism of acquired resistance to antihormone therapy through cell population selection pressure and enrichment during treatment. Circulating tumor cells containing ER mutations can be cultured ex vivo, and tumor tissues can be grown as patient-derived xenografts to add a new dimension for testing drug susceptibility for future drug discovery.
Anti-Ischemic Effect of a Novel Cardioprotective Agent, JTV519, Is Mediated Through Specific Activation of δ-Isoform of Protein Kinase C in Rat Ventricular Myocardium (2000)

The mechanism of cardioprotection by JTV519 against ischemia/reperfusion injury involves isozyme-specific PKC activation through a receptor-independent mechanism. This agent may provide a novel pharmacological approach for the treatment of patients with acute coronary diseases via a subcellular mechanism mimicking ischemic preconditioning.