gebhart/patrepeval huggingface dataset:
Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer (2001)

Kallikrein gene 5 (KLK5, also known as KLK-L2), located on chromosome 19q13.4, is one of the newly identified members of the kallikrein gene family, which is a subgroup of the serine protease enzyme family. In normal human tissues, KLK5 is highly expressed in skin, mammary gland and testis. Preliminary RT-PCR analysis has indicated that KLK5 is expressed in a subset of ovarian tumours. We have thus hypothesized that KLK5 may be a new prognostic indicator in ovarian cancer. We have examined the mRNA expression of KLK5 in 142 malignant ovarian tissues. Tumours were pulverized, total RNA was extracted, and cDNA was prepared by reverse transcription. KLK5 was amplified by PCR using gene specific primers, and the identity of the PCR product was verified by sequencing. Ovarian tissues were then classified as KLK5 positive or negative, based on ethidium bromide staining of the PCR product on agarose gels. KLK5 was found to be highly expressed in 58/142 (41%) of ovarian cancer samples while its level of expression was very low in normal ovarian tissues. We found a strong positive relation between KLK5 expression and tumour grade (P = 0.006) and disease stage (P = 0.027). Univariate survival analysis revealed that patients with ovarian tumours positive for KLK5 expression had an increased risk for relapse and death (P = 0.018 and 0.022, respectively). In multivariate analysis, KLK5 expression showed independent prognostic value only in the subset of tumours with lower grade disease (grades I and II). We conclude that KLK5 expression is associated with more aggressive forms of epithelial ovarian carcinoma and has indepdent prognostic value in low grade tumours.
Expression of a dominant negative IFN‐γreceptor on mouse oligodendrocytes (2005)

The interferon-gamma (IFN-gamma) receptor is expressed by all nucleated cells, and binding of its cognate ligand, IFN-gamma, induces a wide variety of biological functions. Transgenic mice expressing a dominant negative IFN-gamma receptor 1 (IFN-gammaR1DeltaIC) on oligodendrocytes under control of the myelin proteolipid protein promoter are described. The mRNA encoding the transgene was only detected in the nervous system and protein expression was confirmed by immunohistochemistry. Transgenic receptor expression does not alter myelination and the mice exhibited no clinically apparent phenotype. Consistent with the restricted nervous system expression of the transgene, no alterations in peripheral immune responses were detected. Flow cytometric analysis demonstrated constitutive expression of both the IFN-gammaR1DeltaIC transgene and the endogenous IFN-gamma receptor 2 at high levels on oligodendrocytes derived from the transgenic mice. These oligodendrocytes also exhibited decreased STAT1 phosphorylation in response to IFN-gamma, confirming dominant negative transgene function. Transgenic mice in which oligodendrocytes have a diminished ability to respond to IFN-gamma showed delayed virus clearance from oligodendroglia compared with wild-type mice. This model will allow evaluation of oligodendrocyte responses to this critical cytokine during CNS inflammation.
The molecular interactions with helper T cells which limit antigen‐specific B cell differentiation (1988)

Helper T (Th) cell-dependent activation requirements for 2,4,6-trinitrophenyl (TNP)-specific resting B cells obtained from mice transgenic for Sp-6 mu, kappa genes were analyzed. Carrier-specific T cell help required linked recognition of TNP carrier and was functionally restricted by the B cell major histocompatibility complex. However, histoincompatible T cell-B cell conjugates formed by bridging surface immunoglobulin and Th cell receptor for antigen (TcR) through TNP-conjugated anti-TcR antibodies resulted in the efficient differentiation of TNP-specific B cells. Thus, Th cell-dependent cognate recognition of B cells is not obligatory. Specific conjugate formation could be obviated by using unconjugated fragments of anti-TcR antibodies. If dimeric, these fragments supported the Th cell-dependent differentiation of co-cultured histoincompatible resting B cells. Unconjugated monomeric fragments were ineffective, demonstrating the necessity for TcR cross-linking. Resting B cells from Sp-6+ mice rendered TNP-conjugated monomeric fragments of anti-TcR antibodies effectively multivalent, thereby satisfying conditions for the activation of co-cultured Th cells. The results demonstrate that Th cells do not transduce activation signals through TcR recognition of B cell membrane-associated ligand which limit the induction of B cell differentiation. Cross-linking of TcR on Th cells is required, sufficient and can be induced through interaction with the antigen-specific B cell surface.
Effects of Music on Patient Anxiety (2003)

Undergoing surgery with local anesthesia is stressful because patients often are aware of their surroundings. This study investigated music as a method of reducing patients' anxiety during minor surgery with local anesthesia. For this study, researchers assessed the effectiveness of music as a relaxation modality by measuring patients' vital signs and self-reported anxiety before and after surgery. Study results indicate that patients who listened to their choice of music during surgery experienced significantly lower anxiety levels, heart rates, and blood pressure than patients who did not listen to music.
Fibrin–antibiotic mixtures: An in vitro study assessing the possibility of using a biologic carrier for local drug delivery (1991)

An in vitro study assessing the kinetics of drug release from antibiotic-fibrin seal compounds and the antibacterial efficacy of the delivered drug has been performed. Antibiotic sensitivity and the amount of drug released was measured by means of agar diffusion test. Standard and experimental curves were established for each antibiotic and each bacterial test in order to evaluate the quantities of the drug released during each 24 h period. The reconstitution of lyophilized human fibrin with an aqueous solution containing an antibiotic resulted in only minor modification of the clotting process, with the exception of those solutions containing cefotaxim and mezlocillin which failed to clot altogether and were excluded from further study. The evaluation of the kinetics of elution of the antibiotics from the fibrin clots showed that all of the antibiotics had been almost completely released by 96 h. The delivered amount of each drug was enough to maintain the Minimal Inhibitory Concentration (MIC) until the 4th day of culture for the most of antibiotics, resulting in a prolonged release of the drug.
A 3 V low-power 0.25 μm CMOS 100 Mb/s receiver for Fast Ethernet (2002)

A transceiver with excellent performance was recently reported. However, a higher level of integration for multi-channel transceivers for switch application and also for battery-operated laptop markets demands a device with a much lower power consumption with no performance degradation. This AGC and equalizer architecture and circuits address this demand for a low-power transceiver.
Radicicol, an Agent Inducing the Reversal of Transformed Phenotypes ofsrc-Transformed Fibroblasts (1992)

Journal Article Radicicol, an Agent Inducing the Reversal of Transformed Phenotypes of src-Transformed Fibroblasts Get access Ho Jeong Kwon, Ho Jeong Kwon Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Minoru Yoshida, Minoru Yoshida Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Keiichi Abe, Keiichi Abe Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Sueharu Horinouchi, Sueharu Horinouchi Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Teruhiko Beppu Teruhiko Beppu Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 56, Issue 3, 1 January 1992, Pages 538–539, https://doi.org/10.1271/bbb.56.538 Published: 01 January 1992 Article history Received: 02 September 1991 Published: 01 January 1992
Isolation of TSH and LH/CG Receptor cDNAs from Human Thyroid: Regulation by Tissue Specific Splicing (1990)

A TSH receptor (TSH-R) cDNA has been isolated from a human thyroid lambda GT11 library. Unexpectedly, several cDNAs encoding the human LH/CG receptor (LH/CG-R), previously thought to be expressed solely in gonadal cells, were also isolated from the thyroid library. The receptors are structurally related, consisting of a signal sequence, a large extracellular amino terminal domain, seven membrane spanning domains, and a short carboxyl-terminal portion. The TSH-R is encoded by a single 4.2 kilobase mRNA specific to the thyroid. Introns were not present in any hTSH-R cDNAs examined, however, sequencing of several LH/CG-R cDNAs and RNase protection experiments demonstrated that the majority of hLH/CG-R mRNA in the thyroid is incompletely spliced. Consequently, tissue-specific splicing may be an important step in the regulation of the glycoprotein hormone receptor family.
Randomness in Integrated Circuits with Applications in Device Identification and Random Number Generation (2023)

I thank my advisor Professor Wayne Burleson for teaching me integrated circuits, and motivating and guiding the research. Professor Kevin Fu for introducing me to both security and RFID, and for his considerable help and enthusiasm in driving the work. Professor Israel Koren for serving on my thesis committee. Professor Adam Stubblefield of Computer Science at Johns Hopkins University and Dr. Ari Juels of RSA Labs for providing feedback on early versions of the work, and Adam for his pointers on how to generate random numbers. Intel Research and Joshua R. Smith for providing and supporting the WISP platforms. Professor Sandip Kundu for his help with understanding the costs of manufacturing integrated circuits. I thank all of my collaborators in RFID-CUSP and VLSI Circuits and Systems Group for their input, feedback, and help that made the work possible. Outside of the scope of this thesis, I thank my family, and the faculty, staff, and students of UMass Amherst, who have given me great support throughout my many years in Amherst. This material is based upon work supported by the National Science Foundation under Grant No. 0627529. iv
The influence of external compression on muscle blood flow during exercise (1990)

Intramuscular pressures and muscle blood flow were measured in the anterior tibial muscle during dynamic concentric exercise in 14 subjects. Pressures were recorded by the microcapillary infusion method and muscle blood flow by the 133-Xenon clearance technique. Muscle blood flow during constant exercise decreased from 34.5 (SD = 10.3) to 10.6 (SD = 4.9) ml/100 g/min (P less than 0.001) when muscle relaxation pressure was increased from 13.5 (SD = 2.7) to 39.9 (SD = 9.0) mm Hg by external compression. Muscle relaxation pressure during exercise is the intramuscular pressure between contractions. External compression of the lower limb during exercise impedes muscle blood flow by increasing muscle relaxation pressure. The experimental model seems suitable to study the influence of external compression by knee braces on intramuscular pressure during exercise.
Comparison of source scaling relations of eastern and western North American earthquakes (1987)

Abstract Source scaling relations have been obtained for earthquakes in eastern North America and other continental interiors, and compared with a relation obtained for earthquakes in western North America. The scaling relation for eastern North American earthquakes was constructed from measurements of seismic moment and source duration obtained by the waveform modeling of seismic body waves. The events used include nine events of mbLg magnitude 4.7 to 5.8 that occurred after 1960, and four earlier events with magnitudes between 5.5 and 6.6. The scaling relation for events in other continental interiors was used for comparative purposes and to provide constraints for large magnitudes. Detailed analysis of the uncertainties in the scaling relations has allowed the resolution of two important issues concerning the source scaling of earthquakes in eastern North America. First, the source characteristics of earthquakes in eastern North America and other continental interiors are consistent with constant stress drop scaling, and are inconsistent with nonconstant scaling models such as that of Nuttli (1983). Second, the stress drops of earthquakes in eastern North America and other continental interiors are not significantly different from those of earthquakes in western North America, and have median values of approximately 100 bars. The source parameters of earthquakes in eastern North America are consistent with a single constant stress drop scaling relation, whereas the source parameters of earthquakes in western North America are much more variable and show significant departures from an average scaling relation in which stress drop decreases slightly with seismic moment.
Optimization of the Cutoff Value for the Aspergillus Double-Sandwich Enzyme Immunoassay (2007)

A cutoff OD index of 0.5--identical to the approved cutoff in the United States--improves the overall performance of the PA-EIA for adult hematology patients.
Frequency-hopped generalized MC-CDMA for multipath and interference suppression (2002)

Generalized multi-carrier (GMC) CDMA transceivers equipped with frequency hopping are developed in this paper. Through judicious code design, multiuser interference (MUI) is eliminated deterministically and symbol recovery is guaranteed, relying on a minimum number of redundant subcarriers. This, together with subcarrier frequency hopping (FH), improves BER performance in the presence of frequency-selective multipath fading channels and enhances resistance to narrow-band interference. Blind channel estimation methods are developed with guaranteed channel identifiability, regardless of the locations of the zeros of the FIR channel. Performance analysis and simulation results illustrate the merits of the proposed FH-GMC-CDMA transceivers relative to competing OFDMA and multicarrier CDMA alternatives.
Elevating High-Density Lipoprotein Cholesterol in Apolipoprotein E-Deficient Mice Remodels Advanced Atherosclerotic Lesions by Decreasing Macrophage and Increasing Smooth Muscle Cell Content (2001)

Increasing HDL cholesterol levels in EKO mice retards progression of advanced atherosclerotic lesions and remodels them to a more stable-appearing phenotype.
Direct Visualization of Epicardial Structures and Ablation Utilizing a Visually Guided Laser Balloon Catheter: Preliminary Findings (2011)

The investigational laser balloon catheter can be manipulated within the epicardial space, allowing for direct visualization of surrounding structures during ablation. Titration of laser power can be utilized to create moderate-sized ablation lesions while avoiding steam pops.
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor (1992)

Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA residues within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of specificity of action of homeodomain proteins in development.
Using Hardware Performance Monitors to Isolate Memory Bottlenecks (2000)

In this paper, we present and evaluate two techniques that use different styles of hardware support to provide data structure specific processor cache information. In one approach, hardware performance counter overflow interrupts are used to sample cache misses. In the other, cache misses within regions of memory are counted to perform an n-way search for the areas in which the most misses are occurring. We present a simulation-based study and comparison of the two techniques. We find that both techniques can provide accurate information, and describe the relative advantages and disadvantages of each.
Oxygen free radicals in ischemic acute renal failure in the rat. (1984)

During renal ischemia, ATP is degraded to hypoxanthine. When xanthine oxidase converts hypoxanthine to xanthine in the presence of molecular oxygen, superoxide radical (O-2) is generated. We studied the role of O-2 and its reduction product OH X in mediating renal injury after ischemia. Male Sprague-Dawley rats underwent right nephrectomy followed by 60 min of occlusion of the left renal artery. The O-2 scavenger superoxide dismutase (SOD) was given 8 min before clamping and before release of the renal artery clamp. Control rats received 5% dextrose instead. Plasma creatinine was lower in SOD treated rats: 1.5, 1.0, and 0.8 mg/dl vs. 2.5, 2.5, and 2.1 mg/dl at 24, 48, and 72 h postischemia. 24 h after ischemia inulin clearance was higher in SOD treated rats than in controls (399 vs. 185 microliter/min). Renal blood flow, measured after ischemia plus 15 min of reflow, was also greater in SOD treated than in control rats. Furthermore, tubular injury, judged histologically in perfusion fixed specimens, was less in SOD treated rats. Rats given SOD inactivated by prior incubation with diethyldithiocarbamate had plasma creatinine values no different from those of control rats. The OH X scavenger dimethylthiourea (DMTU) was given before renal artery occlusion. DMTU treated rats had lower plasma creatinine than did controls: 1.7, 1.7, and 1.3 mg/dl vs. 3.2, 2.2, and 2.4 mg/dl at 24, 48, and 72 h postischemia. Neither SOD nor DMTU caused an increase in renal blood flow, urine flow rate, or solute excretion in normal rats. The xanthine oxidase inhibitor allopurinol was given before ischemia to prevent the generation of oxygen free radicals. Plasma creatinine was lower in allopurinol treated rats: 2.7, 2.2, and 1.4 mg/dl vs. 3.6, 3.5, and 2.3 mg/dl at 24, 48, and 72 h postischemia. Catalase treatment did not protect against renal ischemia, perhaps because its large size limits glomerular filtration and access to the tubular lumen. Superoxide-mediated lipid peroxidation was studied after renal ischemia. 60 min of ischemia did not increase the renal content of the lipid peroxide malondialdehyde, whereas ischemia plus 15 min reflow resulted in a large increase in kidney lipid peroxides. Treatment with SOD before renal ischemia prevented the reflow-induced increase in lipid peroxidation in renal cortical mitochondria but not in crude cortical homogenates. In summary, the oxygen free radical scavengers SOD and DMTU, and allopurinol, which inhibits free radical generation, protected renal function after ischemia. Reperfusion after ischemia resulted in lipid peroxidation; SOD decreased lipid peroxidation in cortical mitochondria after renal ischemia and reflow. We concluded that restoration of oxygen supply to ischemic kidney results in the production of oxygen free radicals, which causes renal injury by lipid peroxidation.
Introduction and Preview (2004)

The state space representation of linear systems is fundamental to the analysis and design of dynamical systems. Modern control theory relies heavily on the state space representation of dynamical systems, which facilitates characterization of the inherent properties of dynamical systems. Since the introduction of the concept of a state, the study of linear systems in the state space representation itself has emerged as an ever active research area, covering a wide range of topics from the basic notions of stability, controllability, observability, redundancy and minimality to more intricate properties of finite and infinite zero structures, invertibility, and geometric subspaces. A deeper understanding of linear systems facilitates the development of modern control theory. The demanding expectations from modern control theory impose an ever increasing demand for the understanding and utilization of subtler properties of linear systems.
Models of Collecting (1996)

Journal Article Models of Collecting Get access Werner Muensterberger : Collecting: An Unruly Passion ( Princeton University Press : Princeton , 1994 ), 12 b & w illns, 295 pp. hardback ISBN 0-691-03361-7 , £17.95 John Elsner and Roger Cardinal (eds.): The Cultures of Collecting ( Reaktion Books : London , 1994 ), 59 b & w illns, 312 pp. paperback ISBN 0-948462-51-5 , £10.95. Susan M. Pearce (ed.): Interpreting Objects and Collections ( Routledge : London and New York , 1994 ), 343 pp. paperback ISBN 0-415-11289-3 , £19.99 Jacques Guillerme and Dominique Poulot (eds.): Les Collections. Fables et programmes ( Editions Champ Vallon : Seyssel, France , 1993 ), 368 pp. paperback ISBN 2-87673-132-0 , 185FF. TING CHANG TING CHANG Search for other works by this author on: Oxford Academic Google Scholar Oxford Art Journal, Volume 19, Issue 2, 1996, Pages 95–97, https://doi.org/10.1093/oxartj/19.2.95 Published: 01 December 1996
ChemInform Abstract: Products Active on Mosquitoes. Part 7. Synthesis and Biological Activity of Longifolene Derivatives. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of the Saccharomyces Spindle Pole by Matrix-assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (1998)

A highly enriched spindle pole preparation was prepared from budding yeast and fractionated by SDS gel electrophoresis. Forty-five of the gel bands that appeared enriched in this fraction were analyzed by high-mass accuracy matrix-assisted laser desorption/ ionization (MALDI) peptide mass mapping combined with sequence database searching. This identified twelve of the known spindle pole components and an additional eleven gene products that had not previously been localized to the spindle pole. Immunoelectron microscopy localized eight of these components to different parts of the spindle. One of the gene products, Ndc80p, shows homology to human HEC protein (Chen, Y., D.J. Riley, P-L. Chen, and W-H. Lee. 1997. Mol. Cell Biol. 17:6049-6056) and temperature-sensitive mutants show defects in chromosome segregation. This is the first report of the identification of the components of a large cellular organelle by MALDI peptide mapping alone.