gebhart/patrepeval huggingface dataset:
Structure of an aluminophosphate EMM-8: a multi-technique approach (2007)

The crystal structure of an aluminophosphate, EMM-8 (ExxonMobil Material #8), was determined in its calcined, anhydrous form from synchrotron powder diffraction data using the computer program FOCUS. A linkage of double four-ring (D4R) building units forms a two-dimensional framework with 12-MR and 8-MR channels, and differs from a similar SAPO-40 (AFR) framework only by the relationship between paired D4R units. Rietveld refinement reveals a fit of the model to the observed synchrotron data by Rwp=0.1118, R(F2)=0.1769. Local environments of the tetrahedral phosphorus and aluminium sites were established by solid-state NMR, which detects distinct differences between as-synthesized and calcined materials. Distinct, reversible changes in the local symmetry of the P and Al atoms were observed by NMR upon calcination and subsequent hydration. These NMR data provided important constraints on the number of tetrahedral (T) atoms per unit cell and the connectivities of the T atoms. Detailed local structural information obtained by solid-state NMR thereby guided the ultimate determination of the structure of AlPO EMM-8 from the powder data. Comparisons are made to the recently published crystal structure of the fluoride-containing, as-synthesized SSZ-51, indicating that the unit-cell symmetry, axial dimensions and framework structure are preserved after calcination.
Scalable Object Detection Using Deep Neural Networks (2014)

Deep convolutional neural networks have recently achieved state-of-the-art performance on a number of image recognition benchmarks, including the ImageNet Large-Scale Visual Recognition Challenge (ILSVRC-2012). The winning model on the localization sub-task was a network that predicts a single bounding box and a confidence score for each object category in the image. Such a model captures the whole-image context around the objects but cannot handle multiple instances of the same object in the image without naively replicating the number of outputs for each instance. In this work, we propose a saliency-inspired neural network model for detection, which predicts a set of class-agnostic bounding boxes along with a single score for each box, corresponding to its likelihood of containing any object of interest. The model naturally handles a variable number of instances for each class and allows for cross-class generalization at the highest levels of the network. We are able to obtain competitive recognition performance on VOC2007 and ILSVRC2012, while using only the top few predicted locations in each image and a small number of neural network evaluations.
Data Mining for Wearable Sensors in Health Monitoring Systems: A Review of Recent Trends and Challenges (2013)

The past few years have witnessed an increase in the development of wearable sensors for health monitoring systems. This increase has been due to several factors such as development in sensor technology as well as directed efforts on political and stakeholder levels to promote projects which address the need for providing new methods for care given increasing challenges with an aging population. An important aspect of study in such system is how the data is treated and processed. This paper provides a recent review of the latest methods and algorithms used to analyze data from wearable sensors used for physiological monitoring of vital signs in healthcare services. In particular, the paper outlines the more common data mining tasks that have been applied such as anomaly detection, prediction and decision making when considering in particular continuous time series measurements. Moreover, the paper further details the suitability of particular data mining and machine learning methods used to process the physiological data and provides an overview of the properties of the data sets used in experimental validation. Finally, based on this literature review, a number of key challenges have been outlined for data mining methods in health monitoring systems.
The benefits of VAC therapy in the management of pressure ulcers (2004)

This study investigates whether vacuum-assisted closure (VAC) therapy, alginate or hydrocolloid dressing are most effective in the treatment of pressure ulcers. A total of 281 patients were included in this study. The response of each patient's wound was monitored, satisfactory wound closure was examined and the time taken to attain satisfactory wound closure was also taken into consideration. An original analysis of the published data was carried out. Most of the pressure ulcers showed some response in all of the categories investigated, with pressure ulcers in the VAC therapy group showing a greater response in all aspects than those in the other two groups.
CULTIVATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS WITH CONTROLLED AGGREGATE SIZE AND GEOMETRICAL ARRANGEMENT BY INVERTING MICROWELL ARRAY CHIP (2013)

This paper reports a novel cell culture chip, namely “inverting microwell array chip”, for cultivation of human induced pluripotent stem cells with controlled microenvironment. Our “inverting microwell array chip” comprises a lower hydrogel microwell array and an upper polystyrene (PS) culture surface. We demonstrate the formation of uniform human induced pluripotent stem cell aggregates in the microwell array, and after inversion, a culture with controlled aggregate size and geometrical arrangement on the PS surface.
Inducible and tissue-specific expression of rat alpha -1-acid glycoprotein in transgenic mice. (1990)

alpha-1-Acid glycoprotein (AGP), which is produced in the mammalian liver and secreted into the blood-stream, is regulated by steroid hormones and by mediators of the acute phase response. In vitro transfection studies have shown that the response to glucocorticoids requires a cis-acting regulatory element, termed the glucocorticoid response element, that is located within 120 bp of the transcriptional start-site of the gene; induction by the acute phase mediators requires a different element, termed the distal regulatory element (DRE), that is located about 5 kb upstream of the start-site. To determine if these elements function in vivo, we have produced and characterized transgenic mice containing rat AGP gene constructs with and without the DRE. Five transgenic lines were produced from a 9.5-kb genomic AGP containing 4.7 kb of the 5' flanking region; this construct lacks the DRE. Another transgenic line was derived from a 10.7-kb clone that contains 5.3 kb of 5' flanking sequences including the DRE. All transgenic mice produced high levels of immunologically detectable rat AGP in the circulation, comparable to or in excess of that found in normal rats. There were correspondingly high concentrations of rat AGP transcripts in the liver. Transgene expression in all lines was induced in response to dexamethasone and during acute inflammation resulting from LPS treatment. The DRE-containing transgene underwent a greater induction in response to LPS than to dexamethasone; the transgene lacking the DRE responded similarly to both treatments. In cultured primary hepatocytes, the DRE-containing transgene was induced by the acute phase cytokines IL-1 and IL-6, and by dexamethasone, administered individually or in combination; the transgene lacking the DRE responded only to dexamethasone, and was not affected by the peptide hormones. Together, these results provide in vivo evidence supporting the notion that a minimum of two upstream sequences are responsible for the inflammatory induction of rat AGP. One element, which is located within the smaller 9.7-kb restriction fragment, is responsive to glucocorticoids and is likely to be the glucocorticoid response element located close to the transcriptional start site. The other element, the DRE, is located much further upstream and is responsible for imparting responsiveness to the acute phase cytokines.
Mirror-type optical branch and switch (1978)

An optical branch and switch based on a unique mirror effect were fabricated by varying the amount of Ti diffused in a LiNbO(3) waveguide, and their properties were investigated. In this type of optical branch, the branching ratio of the light intensity could be varied by the electric field as well as by the separating angle and the effective indices of the waveguides. The main features of this optical switch are (1) small and simple electrode form and (2) a separating angle large enough to accommodate a number of switches on a single substrate. The ratio of the optical branch light intensity to that of the main waveguide was varied from 0.10 to 12.4 by applying the electric field from 0 V/microm to 8 V/microm.
Optoelectronic integration in silicon-on-insulator technologies (2002)

Established silicon microelectronics fabrication techniques can be largely exploited to fabricate low-loss, low-cost and high volume optical integrated devices. Because of the availability of a buried insulator layer underneath a thin monocrystalline silicon film, Silicon-On-Insulator substrates are currently shown to be a natural candidate for the integration of guided-wave optics components working at the fiber-optical communications wavelengths of 1.33 and 1.55 /spl mu/m. In this paper, the authors review the basic principles of optical waveguides on SOI materials and describe some recent realizations based on optoelectronic system integration in SOI technologies (waveguides, switches, phase modulator or shifter, etc.).
Advances in Mucoadhesion and Mucoadhesive Polymers (2010)

Mucoadhesion is the ability of materials to adhere to mucosal membranes in the human body and provide a temporary retention. This property has been widely used to develop polymeric dosage forms for buccal, oral, nasal, ocular and vaginal drug delivery. Excellent mucoadhesive properties are typical for hydrophilic polymers possessing charged groups and/or non-ionic functional groups capable of forming hydrogen bonds with mucosal surfaces. This feature article considers recent advances in the study of mucoadhesion and mucoadhesive polymers. It provides an overview on the structure of mucosal membranes, properties of mucus gels and the nature of mucoadhesion. It describes the most common methods to evaluate mucoadhesive properties of various dosage forms and discusses the main classes of mucoadhesives.
Adipocyte spatial distributions in bone marrow: implications for skeletal dosimetry models. (2003)

Electron transport simulations were conducted in 4 different 3D voxel models of trabecular bone for sources localized in the active marrow (TAM), bone volume (TBV), bone endosteum (TBE), and bone surfaces (TBS). Voxel model simulations demonstrated that absorbed fractions to active marrow given by the ICRP 30 model (MIRDOSE2) are exceedingly conservative for both TBV and TBS sources, except in the case of high-energy particles (>500 keV) at high values of marrow cellularity (>70%). Values of both phi(TAM<--TBV) and phi(TAM<--TBS) given by the Eckerman and Stabin model (MIRDOSE3) were shown to be reasonably consistent with 3D voxel model simulations at the reference cellularity of 25%, except in the case of low-energy emitters (<100 keV) on the bone surfaces.
Live mobile panoramic high accuracy augmented reality for engineering and construction (2013)

Augmented reality finds many potential uses in the infrastructure world. However, the work done by architects and engineers has potential impacts on people’s lives. Therefore, the data they base their decisions upon must be accurate and reliable. Unfortunately, so far augmented reality has failed to provide the level of accuracy and robustness that would be required for engineering and construction work using a portable setup. Recent work has shown that panorama based augmentation can provide a level of accuracy that is higher than standard video-based augmentation methods, because of its wider field of view. In this paper, we present a live mobile augmentation method based on panoramic video. The environment is captured live using a high resolution panoramic video camera installed on top of a tripod, and positioned in the area to be augmented. The system is first initialized by the user, who aligns the 3D model of the environment with the panoramic stream. The live scene is then augmented with a 3D CAD model, the augmenting elements being properly occluded by live moving objects in the scene. To augment the scene from a different vantage point, the user grabs the tripod and carries it to the new location. During that time, the system calculates the camera position by tracking optical features identified on the panoramic video stream. When the user places the tripod back on the ground, the system automatically resumes augmentation from the new position. The system was tested in indoor and outdoor conditions. Results demonstrate high tracking accuracy, jitter free augmentation, and that the setup is sufficiently portable to be used on site.
Discovery of Adamantyl Ethanone Derivatives as Potent 11β‐Hydroxysteroid Dehydrogenase Type 1 (11β‐HSD1) Inhibitors (2010)

11Beta-hydroxysteroid dehydrogenases (11beta-HSDs) are key enzymes regulating the pre-receptor metabolism of glucocorticoid hormones. The modulation of 11beta-HSD type 1 activity with selective inhibitors has beneficial effects on various conditions including insulin resistance, dyslipidemia and obesity. Inhibition of tissue-specific glucocorticoid action by regulating 11beta-HSD1 constitutes a promising treatment for metabolic and cardiovascular diseases. A series of novel adamantyl ethanone compounds was identified as potent inhibitors of human 11beta-HSD1. The most active compounds identified (52, 62, 72, 92, 103 and 104) display potent inhibition of 11beta-HSD1 with IC(50) values in the 50-70 nM range. Compound 72 also proved to be metabolically stable when incubated with human liver microsomes. Furthermore, compound 72 showed very weak inhibitory activity for human cytochrome P450 enzymes and is therefore a candidate for in vivo studies. Comparison of the publicly available X-ray crystal structures of human 11beta-HSD1 led to docking studies of the potent compounds, revealing how these molecules may interact with the enzyme and cofactor.
Animal models of obsessive&ndash;compulsive disorder: utility and limitations (2015)

Keywords: obsessive–compulsive disorder (OCD), genetic model, behavioral model, pharmacological model, compulsivity, perseverance
Hypertrophic Cardiomyopathy (1995)

HCM is a heterogeneous disease genotypically, phenotypically, pathophysiologically, clinically, and therapeutically. In decisions on the management of these patients, it is important to recognize this heterogeneity and to direct therapy at the predominant abnormalities.
The causes of autism spectrum disorders (2003)

The first Exchange-Traded Note (ETN) was introduced in 2006. Since then, at least 64 other ETNs have been issued, with more announced. This financial security, which is growing in number and popularity, is often confused with Exchange-Traded Funds (ETFs) and seems to be largely misunderstood by the general investing public and even by institutional investors and academicians. Since no academic work has been published on the subject, this article offers a seminal introduction to ETNs. It provides five basic categories of information: 1) descriptive information about ETNs, 2) fine print related to ETNs that we believe investors should understand before purchasing shares, 3) a few simple examples of ETNs that are available, 4) a simple analysis of how closely ETN market prices track their indicative values (something akin to NAV), and 5) a discussion of why ETNs may appeal to various investor classes. The authors believe this article will provide the catalyst for much future empirical work on these financial securities. <b>TOPICS:</b>Other real assets, exchange-traded funds and applications, passive strategies
QUANTITATIVE HISTOCHEMICAL ANALYSIS OF MAST CELLS AND SENSORY NERVES IN PSORIATIC SKIN (1996)

To study the elements of neurogenic inflammation in psoriatic skin, morphological contacts were examined between mast cells and sensory nerves containing the neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP) or vasoactive intestinal polypeptide (VIP). Because mast cells in psoriatic lesions appear in great numbers at the basement membrane (BM) zone, neuropeptide–mast cell contacts with the BM were also counted. A double stain for active mast cell tryptase and the neuropeptides was applied and the contacts were quantitated morphometrically. Sensory nerve–mast cell contacts were also studied three-dimensionally with a confocal laser scanning microscope. Increases in the contact values of SP and CGRP with mast cells, as well as with the BM, were obtained in developing (1–3 weeks) lesions when compared with their non-lesional controls. This increase reached statistical significance in mature lesions. In contrast, the corresponding contact values for VIP were decreased. By confocal microscopy, a close association between mast cells and sensory nerves was observed in the lesional dermis. Since tryptase is known to degrade CGRP but not SP, neurogenic stimuli, mainly via SP, can result in degranulation of mast cells, which release substances to enhance inflammation. At the BM zone in psoriatic lesions, the numerous mast cells loaded with tryptase can promote degradation of BM components and allow entry of various mediators to interact with keratinocytes.
Late-onset central hypoventilation syndrome: a family genetic study (2007)

Congenital central hypoventilation syndrome is a rare disorder characterised by chronic alveolar hypoventilation, which becomes more pronounced during sleep and may be associated with neurocristopathies, such as Hirchsprung's disease. A mutation in the PHOX2B gene has recently been identified. In a family of both parents and five offspring, detailed clinical assessment, pulmonary function testing, overnight sleep studies and ventilatory responsiveness to progressive hypercapnia (V'(R,CO(2))) were performed, in addition to analysis of known genetic loci for this condition. The father and four of the offspring demonstrated features of central hypoventilation with nonapnoeic oxygen desaturation during sleep and diminished V'(R,CO(2)), despite normal pulmonary function. The lowest sleep saturation was median (range) 79% (67-83%) and V'(R,CO(2)) was 2.1 (0.03-4.3) L x min(-1) x kPa(-1). The normal values for the authors' centre (St Vincent's University Hospital, Dublin, Ireland) are 15-40 L x min(-1) x kPa(-1). An in-frame five amino acid polyalanine expansion of the PHOX2B gene was found in all affected subjects, while the mother and fifth child, who did not have features of central hypoventilation, had a normal PHOX2B gene. Magnetic resonance imaging of the brainstem in one severely affected child was normal. The present study of a unique family confirms that transmission of late-onset congenital central hypoventilation syndrome is autosomal dominant in nature.
Biochemistry and Immunology of Poly(ethylene glycol)-Modified Adenosine Deaminase (PEG-ADA) (1997)

Poly(ethylene glycol)-modified bovine adenosine deaminase (PEG-ADA) was the first PEGylated protein to undergo clinical trial. It has been effective in correcting the toxic biochemical effects of ADA substrates, and in treating thefatal immune deficiency disease caused by ADA deficiency. The experience gained from monitoring PEG-ADA therapy over the past decade provides unique insight into the immunological response to chronic treatment with a PEGylated enzyme.
A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma (2016)

Coadministration of vemurafenib and TILs was safe and feasible and generated objective clinical responses in this small pilot clinical trial. Clin Cancer Res; 23(2); 351-62. ©2016 AACRSee related commentary by Cogdill et al., p. 327.
Synthesis of trans- and cis-Sphingosine (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of trans- and cis-SphingosineElmer Reist and Pamela ChristieCite this: J. Org. Chem. 1970, 35, 12, 4127–4130Publication Date (Print):December 1, 1970Publication History Published online23 December 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/jo00837a622https://doi.org/10.1021/jo00837a622research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
COUMARINS FROM 5-n-PENTADECYLRESORCINOL AND THE FRIES REACTION OF THEIR ESTERS (1960)

5-Hydroxycoumarin derivatives have been obtained by the interaction of 5-n-pentadecylresocinoi with ethyl aceto­acetate, ethyl methylacetoacetate and ethyl ethylacetoacetate. The Fries reaction of the acetoxycoumarins in presence of anhydrous aluminium chloride has been studied.
Therapy for metastatic melanoma: the past, present, and future (2012)

Metastatic melanoma is the most aggressive form of skin cancer with a median overall survival of less than one year. Advancements in our understanding of how melanoma evades the immune system as well as the recognition that melanoma is a molecularly heterogeneous disease have led to major improvements in the treatment of patients with metastatic melanoma. In 2011, the US Food and Drug Administration (FDA) approved two novel therapies for advanced melanoma: a BRAF inhibitor, vemurafenib, and an immune stimulatory agent, ipilimumab. The success of these agents has injected excitement and hope into patients and clinicians and, while these therapies have their limitations, they will likely provide excellent building blocks for the next generation of therapies. In this review we will discuss the advantages and limitations of the two new approved agents, current clinical trials designed to overcome these limitations, and future clinical trials that we feel hold the most promise.
Algorithms for separable nonlinear least squares with application to modelling time-resolved spectra (2007)

The multiexponential analysis problem of fitting kinetic models to time-resolved spectra is often solved using gradient-based algorithms that treat the spectral parameters as conditionally linear. We make a comparison of the two most-applied such algorithms, alternating least squares and variable projection. A numerical study examines computational efficiency and linear approximation standard error estimates. A new derivation of the Fisher information matrix under the full Golub-Pereyra gradient allows a numerical comparison of parameter precision under variable projection variants. Under the criteria of efficiency, quality of standard error estimates and parameter precision, we conclude that the Kaufman variable projection technique performs well, while techniques based on alternating least squares have significant disadvantages for application in the problem domain.