gebhart/patrepeval huggingface dataset:
A Distributed Approach for Optimizing Cascaded Classifier Topologies in Real-Time Stream Mining Systems (2010)

In this paper, we discuss distributed optimization techniques for configuring classifiers in a real-time, informationally-distributed stream mining system. Due to the large volume of streaming data, stream mining systems must often cope with overload, which can lead to poor performance and intolerable processing delay for real-time applications. Furthermore, optimizing over an entire system of classifiers is a difficult task since changing the filtering process at one classifier can impact both the feature values of data arriving at classifiers further downstream and thus, the classification performance achieved by an ensemble of classifiers, as well as the end-to-end processing delay. To address this problem, this paper makes three main contributions: 1) Based on classification and queuing theoretic models, we propose a utility metric that captures both the performance and the delay of a binary filtering classifier system. 2) We introduce a low-complexity framework for estimating the system utility by observing, estimating, and/or exchanging parameters between the inter-related classifiers deployed across the system. 3) We provide distributed algorithms to reconfigure the system, and analyze the algorithms based on their convergence properties, optimality, information exchange overhead, and rate of adaptation to non-stationary data sources. We provide results using different video classifier systems.
Modulation by interferons of HLA antigen, high-molecular-weight melanoma associated antigen, and intercellular adhesion molecule 1 expression by cultured melanoma cells with different metastatic potential. (1989)

The effect of leukocyte (IFN-alpha), fibroblast (IFN-beta), and immune (IFN-gamma) interferon and/or mezerein on the expression of HLA antigens and melanoma-associated antigens by the melanoma cell line MeWo and its metastatic variant MeM 50-10 was investigated, since this information may contribute to our understanding of the molecular mechanism(s) underlying the metastatic process and of the role of cell differentiation and growth suppression in the antigenic changes induced by interferon (IFN). The three types of IFN had no effect on the expression of high-molecular-weight melanoma-associated antigen, but enhanced that of HLA Class 1 antigens and of intercellular adhesion molecule 1 on MeWo and MeM 50-10 cells. The enhancing effect of IFN-gamma was more marked than that of IFN-alpha and IFN-beta. Furthermore IFN-gamma enhanced the expression of intercellular adhesion molecule 1 by MeM 50-10 cells more than by MeWo cells. IFN-beta was shown for the first time to induce HLA Class II antigens; the effect of IFN-beta, like that of IFN-gamma, is differential on the two cell lines and on the gene products of the HLA-D region. Like IFN-gamma, IFN-beta induced only HLA-DR antigens on MeM 50-10 cells. The results of Northern blot analysis with HLA-DR beta, -DQ beta, and -DP beta probes suggest that the differential modulation of the gene products of the HLA-D region by IFN-beta and IFN-gamma reflects transcriptional and posttranscriptional events. The differential susceptibility to modulation by IFN-beta and IFN-gamma of HLA Class II antigens on MeWo and MeM 50-10 cells is an intrinsic property of each cell line, since only small differences were detected in the number and/or affinity of receptors on the two cell lines. Furthermore, the lack of marked effects of mezerein on the antigen-modulating activity of the three types of IFN, in spite of an enhancement of their differentiating activity, suggests that the changes in the antigenic profile induced by IFN do not represent a differentiation-related phenomenon.
Catalytic Asymmetric Synthesis of Chiral Tertiary Organoboronic Esters through Conjugate Boration of β-Substituted Cyclic Enones (2009)

The first catalytic enantioselective conjugate boration of beta-substituted cyclic enones was developed to produce enantiomerically enriched tertiary organoboronates. The optimized asymmetric catalyst includes a QuinoxP*-CuO(t)Bu complex generated from CuPF(6)(CH(3)CN)(4) and LiO(t)Bu. In situ generated LiPF(6) significantly increased product yield. The enantioselectivity, however, was almost constant irrespective of the alkali metal used (Li, Na, or K). Moreover, a protic additive, which was essential in the previous Cu-catalyzed enantioselective boration to linear beta-monosubstituted substrates (Yun's reaction), was not necessary. The substrate scope was broad, and high to excellent enantioselectivity was produced using both beta-aromatic and aliphatic (linear and branched)-substituted cyclic enones with five-, six-, and seven-membered ring sizes. Due to the synthetic versatility of organoboron compounds, a variety of new chiral building blocks containing a chiral tetrasubstituted carbon was synthesized based on this methodology. Specifically, a one-pot three-component reaction from alpha,beta-substituted cyclic enone, bis(pinacolato)diboron (PinB-BPin: 2), and an aldehyde proceeded with a high level of enantio- and diastereocontrol. These chiral building blocks are difficult to access using other methods.
Review: Combination therapy in high-risk stage II or stage III colon cancer: current practice and future prospects (2010)

Colon cancer represents the second leading cause of cancer-related deaths. For patients who have undergone curative surgery, adjuvant therapy can reduce the risk of recurrence and death from relapsed or metastatic disease. Postoperative chemotherapy with a 5-fluorouracil-based regimen combined with oxaliplatin is the current standard of care for stage III patients. However, there is still controversy in stage II disease about the real impact of adjuvant monotherapy or combined therapy on survival. Better identification of a subgroup of patients with a higher risk of recurrence can select patients who might benefit from adjuvant therapy. For the elderly population, there is a well-established role for postoperative therapy, although the most appropriate regimen remains to be defined. Targeted agents for combined adjuvant therapy in stage II and III colon cancer is a promising area, but to date, there is no evidence supporting its use in this setting. Results from large prospective trials with targeted therapy have been disappointing and new drugs and strategies are needed to define the role of these types of agents in the adjuvant scenario of colon cancer.
A Phase I Escalating-Dose Safety, Dosimetry and Efficacy Study of Radiolabeled Monoclonal Antibody LYM-1 (1993)

Thirteen patients with relapsed or refractory Non-Hodgkin's Lymphoma were treated with 131I-Lym-1 during the course of a dose escalation trial. Principal aims were to establish the maximum tolerated single dose (MTD), as well as to assess clinical and dosimetric effects of the MTD. Patients were eligible if > 25% of tumor cells bound Lym-1 on immunohistochemistry, stain intensity was +2/4 or greater and human anti-mouse antibody (HAMA) assay was negative. Radioimmunotherapy was performed with escalating doses at levels of 50 mCi, 65 mCi/m2 and 80 mCi/m2 (50-139 mCi total). Patients were eligible for retreatment after 6-10 weeks if there was no severe toxicity, their disease was at least stable and HAMA remained negative. Three were retreated. Four have achieved partial responses which lasted 11, 11, 18 and 22 weeks. Acute toxicities included rigors (69%), fever (62%), nausea (46%), vomiting (46%), pruritus (23%), urticaria (23%), chest pain (23%) and bronchospasm (15%). HAMA developed in 3 patients. Myelosuppression, manifested as thrombocytopenia and neutropenia, was dose-limiting and defined the single dose MTD at 65 mCi/m2. Plasma radioactivity clearance was biphasic, with a 0.9 hr alpha-T1/2 and a 19.8 hr beta-T1/2. At completion of Lym-1 infusion, a mean of 45% of the injected dose was recoverable in the circulation. Images obtained within the first 2 hours indicated mean hepatic and splenic uptake was 29% and 11%, respectively. Radiation absorbed doses to tumor ranged from 18-61 rads; mean doses to whole body ranged from 17 to 71 rads.
Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver (2007)

Adeno-associated virus (AAV)-mediated gene transfer of factor IX (F.IX) to the liver results in long-term expression of transgene in experimental animals, but only short-term expression in humans. Loss of F.IX expression is likely due to a cytotoxic immune response to the AAV capsid, which results in clearance of transduced hepatocytes. We used a nonhuman primate model to assess the safety of AAV gene transfer coupled with an anti-T-cell regimen designed to block this immune response. Administration of a 3-drug regimen consisting of mycophenolate mofetil (MMF), sirolimus, and the anti-IL-2 receptor antibody daclizumab consistently resulted in formation of inhibitory antibodies to human F.IX following hepatic artery administration of an AAV-hF.IX vector, whereas a 2-drug regimen consisting only of MMF and sirolimus did not. Administration of daclizumab was accompanied by a dramatic drop in the population of CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs). We conclude that choice of immunosuppression (IS) regimen can modulate immune responses to the transgene product upon hepatic gene transfer in subjects not fully tolerant; and that induction of transgene tolerance may depend on a population of antigen-specific Tregs.
Aqueous base developable novel deep-UV resist for KrF excimer laser lithography (1990)

A novel deep-UV resist which consists of poly(p-trimethylsilyloxystyrene) and pnitrobenzyl- 9,10-diethoxyanthracene-2-sulfonate showed capability of resolving 0.3 im lines and spaces with steep sidewalls at 0.8 im thickness by use of a KrF excimer laser stepper. Wet development in a conventional tetramethylammonium hydroxide developer caused no critical thickness loss in the unexposed area. Owing to its oxygen plasma durability, this resist was shown to work as a top layer of a bi-layer resist.
Spectroscopy of third-harmonic generation: evidence for resonances in model compounds and ligated hemoglobin (2006)

We report on third-harmonic generation (THG) of biomolecular solutions at the fluid/glass interface as a means to probe resonant contributions to their nonlinear absorption spectra that could serve as contrast mechanisms for functional imaging. Our source was 100 fs laser pulses whose center wavelength varied from 760 to 1000 nm. We find evidence of a two-photon resonance in the ratio of third-order susceptibilities, χ(3)sample (3ω)/χ(3)glass, for aqueous solutions of Rhodamine B, Fura-2, and hemoglobin and a three-photon resonance in χ(3)sample (3ω)/χ(3)glass for solutions of bovine serum albumin. Consistent with past work, we find evidence of a one-photon resonance of χ(3)sample (3ω)/χ(3)glass for water, while confirming a lack of resonant enhancement for benzene. At physiological concentrations, hemoglobin in different ligand-binding states could be distinguished on the basis of features of its THG spectrum.
Role of Repulsive Forces in Determining the Equilibrium Structure of Simple Liquids (1971)

The different roles the attractive and repulsive forces play in forming the equilibrium structure of a Lennard-Jones liquid are discussed. It is found that the effects of these forces are most easily separated by considering the structure factor (or equivalently, the Fourier transform of the pair-correlation function) rather than the pair-correlation function itself. At intermediate and large wave vectors, the repulsive forces dominate the quantitative behavior of the liquid structure factor. The attractions are manifested primarily in the small wave vector part of the structure factor; but this effect decreases as the density increases and is almost negligible at reduced densities higher than 0.65. These conclusions are established by considering the structure factor of a hypothetical reference system in which the intermolecular forces are entirely repulsive and identical to the repulsive forces in a Lennard-Jones fluid. This reference system structure factor is calculated with the aid of a simple but accurate approximation described herein. The conclusions lead to a very simple prescription for calculating the radial distribution function of dense liquids which is more accurate than that obtained by any previously reported theory. The thermodynamic ramifications of the conclusions are presented in the form of calculations of the free energy, the internal energy (from the energy equation), and the pressure (from the virial equation). The implications of our conclusions to perturbation theories for liquids and to the interpretation of x-ray scattering experiments are discussed.
HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells (2019)

A small number of HIV-1-infected individuals develop broadly neutralizing antibodies to the virus (bNAbs). These antibodies are protective against infection in animal models. However, they only emerge 1-3 yr after infection, and show a number of highly unusual features including exceedingly high levels of somatic mutations. It is therefore not surprising that elicitation of protective immunity to HIV-1 has not yet been possible. Here we show that mature, primary mouse and human B cells can be edited in vitro using CRISPR/Cas9 to express mature bNAbs from the endogenous <i>Igh</i> locus. Moreover, edited B cells retain the ability to participate in humoral immune responses. Immunization with cognate antigen in wild-type mouse recipients of edited B cells elicits bNAb titers that neutralize HIV-1 at levels associated with protection against infection. This approach enables humoral immune responses that may be difficult to elicit by traditional immunization.
A robust 2400 bps subband LPC vocoder (2002)

This paper presents a new voice coder for applications in future low bit rate communication systems. The emphasis has been put on the speech quality, noise robustness and complexity. The coder realizes a multiband+LPC spectral analysis and synthesis of speech. The transmitted information consists of an LPC10 filter, a set of voicing rates, pitch, energies, spectral density of excitation in five subbands, and information about the stationarity of the signal in each half-frame. Depending upon this stationarity, the quantization process is adapted to provide more spectral information (stable speech) or more temporal information (transitory speech). In order to be less sensitive to the surrounding noise, the pitch and voicing rates are first computed in each subband. The final values of these parameters are obtained from the values in the current frame and its neighbours. The excitation signal used at the synthesis side consists of a mixture of isolated pulses, periodic and aperiodic signals of adjustable spectral composition. Tests results are provided.
Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. (1991)

One thousand and one men, aged 35-65 years, were identified from the age-sex register of one group general practice. Over four years 900 men were visited at home and asked questions about symptoms potentially related to sleep apnoea and snoring. Height, weight, neck circumference, resting arterial oxygen saturation (SaO2), and spirometric values were also determined. All night oximetry was then performed at home and the tracing analysed for the number of dips in SaO2 of more than 4%. Subjects with more than five dips of 4% SaO2 or more per hour were invited for sleep laboratory polysomnography. Seventeen per cent of the men admitted to snoring "often." Multiple linear regression techniques identified and ranked neck circumference (r2 = 7.2%), cigarette consumption (r2 = 3.4%), and nasal stuffiness (r2 = 2%) as the only significant independent predictors of snoring. Together these account for at least a sixfold variation in the likelihood of being an "often" snorer. Forty six subjects (5%) had greater than 4% SaO2 dip rates of over five an hour and 31 of these had full sleep studies. Three subjects had clinically obvious and severe symptomatic obstructive sleep apnoea, giving a prevalence of three per 1001 men (0.3%; 95% confidence interval 0.07-0.9%). Eighteen men had obstructive sleep apnoea only when supine and in 10 the cause of the SaO2 dipping on the original home tracing was not elucidated. The greater than 4% SaO2 dip rates correlated with the history of snoring. Multiple linear regression techniques identified and ranked neck circumference (r2 = 7.9%), alcohol consumption (r2 = 3.7%), age (r2 = 1%) and obesity (r2 = 1%) as the only significant independent predictors of the rate of overnight hypoxic dipping. This study shows that snoring in this randomly selected population correlates best with neck size, smoking, and nasal stuffiness. Obstructive sleep apnoea, defined by nocturnal hypoxaemia, correlates best with neck size and alcohol, and less so with age and general obesity.
Detection of Borrelia burgdorferi-specific CD8+ cytotoxic T cells in patients with Lyme arthritis (1996)

T cells are believed to play an important role in the pathogenesis of Lyme arthritis (LA), an inflammatory joint disease caused by the spirochete Borrelia burgdorferi (Bb). The presence or absence of certain Bb-specific CD4+ T helper cells has been associated with prognosis. Since recent observations suggested the activation of CD8+ T cells during infection with Bb, we searched for CD8+ cytotoxic T lymphocytes in patients with LA. CD8+ T cell lines were generated from peripheral blood and synovial fluid of five patients with LA. In addition, CD8+ T cells were expanded by Ag-specific stimulation in bulk cultures. A cytotoxicity assay was established using target cells infected with recombinant vaccinia viruses expressing the borrelial proteins outer surface protein (Osp) A, OspB, or flagellin. We found Bb-specific CTL lines derived from the peripheral blood of three patients with LA with specificity for flagellin, OspA, and OspB. All Bb-specific CTL lines were CD3+, CD8+, and TCRalphabeta, and cytotoxic activity was HLA class I restricted. Moreover, CD8+ T cells expanded by Ag-specific stimulation in vitro demonstrated Bb-specific and HLA class I-restricted lysis toward individual borrelial proteins. Interestingly, Bb-specific lytic activity was only detected in patient samples obtained after the disappearance of arthritis. We report the detection of Bb-specific cytotoxic CD8+ T cells in patients with LA. The induction of specific CD8+ T cells may play an important role in disease control and may have important bearings for the development of effective vaccines against Lyme borreliosis.
Development of Metabolically Engineered Saccharomyces cerevisiae Cells for the Production of Lactic Acid (1995)

Interesting challenges from metabolically engineered Saccharomyces cerevisiae cells arise from the opportunity to obtain yeast strains useful for the production of chemical(s). In this paper, we describe the accumulation of lactic acid in the culture medium of growing, engineered yeast cells expressing a mammalian lactate dehydrogenase gene (LDH-A). High and reproducible productions (20 g/L) and productivities (up to 11 g/L/h) of lactic acid have been obtained by modulating the physiological growth conditions. Since yeast cells are acid tolerant and survive at very low pH values, the production of lactate can be avoided. In perspective, the approaches described could be useful for the production of lactic acid, outflanking the problems related to the synthesis from bacteria cells. In fact, during industrial productions, there is an inhibitory effect on the metabolic activities of the growing bacteria (i.e., Lactobacillus spp.) caused by the acid produced and by the low pH value. Thus, strategies to prevent the lowering of pH are conventional operations. These processes allow the production of lactate(s) and require the purification of the acid from its salt. The biotechnological implications of this study are also discussed.
Resource management with hoses: point-to-cloud services for virtual private networks (2002)

As IP technologies providing both tremendous capacity and the ability to establish dynamic security associations between endpoints emerge, virtual private networks (VPNs) are going through dramatic growth. The number of endpoints per VPN is growing and the communication pattern between endpoints is becoming increasingly hard to predict. Consequently, users are demanding dependable, dynamic connectivity between endpoints, with the network expected to accommodate any traffic matrix, as long as the traffic to the endpoints does not overwhelm the capacity of the respective ingress and egress links. We propose a new service interface, termed a hose, to provide the appropriate performance abstraction. A hose is characterized by the aggregate traffic to and from one endpoint in the VPN to a set of other endpoints in the VPN, and by an associated performance guarantee. Hoses provide important advantages to a VPN customer: (1) flexibility to send traffic to a set of endpoints without having to specify the detailed traffic matrix, and (2) reduction in the size of access links through multiplexing gains obtained from the natural aggregation of the flows between endpoints. As compared with the conventional point-to-point (or customer pipe) model for managing quality of service (QoS), hoses provide reduction in the state information a customer must maintain. On the other hand, hoses would appear to increase the complexity of the already difficult problem of resource management to support QoS. To manage network resources in the face of this increased uncertainty, we consider both conventional statistical multiplexing techniques, and a new resizing technique based on online measurements. To study these performance issues, we run trace-driven simulations, using traffic derived from AT&T's voice network and from a large corporate data network. From the customer's perspective, we find that aggregation of traffic at the hose level provides significant multiplexing gains. From the provider's perspective, we find that the statistical multiplexing and resizing techniques deal effectively with uncertainties about the traffic, providing significant gains over the conventional alternative of a mesh of statically sized customer pipes between endpoints.
Presenting Windows Workflow Foundation (2005)

Presenting Windows Workflow Foundation is a premium reference that provides information on a key part of WinFX, providing universally accessible and consistent workflow technology for the Windows platform. Windows Workflow Foundation delivers an API as part of WinFX and a workflow designer hosted in Visual Studio 2005.The Windows Workflow Foundation supports development of both sequential and state-based workflow involving both human and system interaction. Sequential workflow is a map of activities that may be in series or parallel. State-based workflow is a state machine where events cause transitions. Rules can be specified that drive decision making in a workflow and can be updated easily at runtime. Workflow can be created as a model and executed inside many host applications including Windows Forms, console applications, or Web applications. Key Scenarios that can be developed with Windows Workflow Foundation include: Document management: The steps involved in the review and approval of shared documents or other content. Line of business application: The processing flow or business logic in an extensible part of the application. Website page flow: The flow of state variables between web pages. IT management: Handling of common systems management processes. Decision making logic: Where complex business logic is well described by a sequential or state diagram. Consumer: A common series of steps for consumer PC usage.Download the source code from the book at www.samspublishing.com