gebhart/patrepeval huggingface dataset:
Managing urinary incontinence: what works? (2014)

Urinary incontinence is a common condition, which, although not life-threatening, impairs the health-related quality of life of affected individuals. All women complaining of incontinence require a basic assessment and those with complex or refractory symptoms may benefit from urodynamic studies. Initial treatment includes lifestyle advice, behavioral modifications, bladder retraining and pelvic floor muscle training. For those women with persistent stress urinary incontinence following conservative therapy, surgical management might be considered. The development of the minimally invasive, retropubic, synthetic, mid-urethral sling procedures has revolutionized stress incontinence surgery and reduced the popularity of 'traditional' procedures, such as colposuspension and autologous fascial sling. In an attempt to reduce further the morbidity, transobturator and single-incision slings have been introduced. While antimuscarinic agents are the mainstay of the current medical management of urgency urinary incontinence, a recently developed selective β3-adrenergic receptor agonist (mirabegron) offers an alternative pharmacological option. Modalities such as intravesical botulinum toxin and neuromodulation (peripheral or sacral) are available to women with refractory urgency incontinence. Finally, when all other options have been explored and proven unsuccessful, inappropriate or not feasible, reconstructive surgery or catheter insertion might be considered as a last resort. The aim of this paper is to review conservative, medical and surgical management for urinary incontinence by using the best available evidence in the literature.
Placebo Effect and Clinical Trials in Migraine Therapy (1987)

Migraine is a cyclical condition in which the cycles may occur or remit in an unpredictable fashion. The goal of prophylactic antimigraine therapy is to induce remission of an active cycle of migraine or to inhibit occurrence of individual headaches until the cycle remits for other reasons. The placebo effect probably takes advantage of these cycles. The placebo effect is significant and quite potent. The placebo effect may be divided into (1) the initial effect and (2) the continuing effect which is seen following a stabilization period. The initial placebo effect is dramatic with 62% of 188 subjects improving by 75% after 4 weeks of placebo. The continuing effect is demonstrated by occurrence of 75% further improvement in 28% of 282 subjects in 7 studies in which comparison of results after 4-12 weeks was made with a placebo stabilization period. The placebo effect is a very potent one and must be taken into account in designing and carrying out studies of migraine therapy.
Detection of the Complement Degradation Product C4d in Renal Allografts (2002)

The immunohistochemical detection of the complement degradation product C4d, a component of the classical complement pathway, offers a new and currently poorly defined tool in the evaluation of renal allograft biopsies. Our retrospective study aims at determining the diagnostic and clinical significance of C4d accumulation in kidney transplants, employing immunofluorescence microscopy. We analyzed 398 diagnostic allograft biopsies (n = 265 patients with 1 to 5 biopsies obtained 7 to 7165 d posttransplantation [tx]) and correlated the detection of C4d with 18 histologic changes, panel-reactive antibody titers, response to treatment, and outcome. One hundred twenty-five native kidney and baseline tx biopsies served as controls. Linear deposition of C4d along peritubular capillaries was only found in a subgroup (30%) of allografts post-tx, mainly during the early time-course (median, 38 d post-tx; range, 7 to 5646 d). There was no significant association with infections. C4d staining could change from negative to positive and vice versa within days to weeks. The accumulation of C4d was most tightly linked to a morphologic subtype of rejection, transplant glomerulitis (P < 0.0001). In addition, tubular MHC class II expression was correlated with C4d deposition (P < 0.0001). Both features are signs of "acute active rejection." In comparison with C4d-negative controls, 43% of C4d-positive patients showed increased (>10%) panel-reactive antibody titers (versus 19% in the negative group; P = 0.001). C4d positivity was frequently associated with higher serum creatinine levels at time of biopsy (compared with C4d-negative group; P < 0.01). More C4d-positive patients were treated with polyclonal antithymocyte globulins (ATG) or monoclonal anti-CD3 antibodies (OKT3) (P < 0.0001). Outcome did not significantly differ between C4d-positive and C4d-negative groups. In conclusion, the detection of C4d identifies a humoral alloresponse in a subgroup of kidney transplants, which is often associated with signs of cellular rejection, i.e. tx glomerulitis. Allograft dysfunction in C4d-positive rejection episodes is often more pronounced. We provide first evidence that C4d-positive rejection might benefit from intensive therapy, potentially preventing the previously reported high graft failure rate. In addition, we show that a subgroup of C4d-positive cases may not require any immediate therapeutic intervention. The presence of C4d is clinically relevant and should be reported in the histologic diagnosis.
日中・日韓関係を修復するには : 東アジア (ISSUES 2014) (2014)

This paper reviews the most common health hazards occurring among personnel of peacekeeping and stabilization missions functioning within armed conflicts in the contemporary world. Military operations have been executed in diverse climatic and sanitary conditions, which are frequently unfamiliar for their participants. Some of them, e.g. the UN peacekeeping missions in the Middle East (Lebanon, the Golan Heights), have been carried out in a relatively stable geopolitical environment; whereas, stabilization missions in Iraq and Afghanistan, which are actually combat activities, undoubtedly fall into the group of the most perilous military operations in the world. Hot or cold climate, poor sanitary and hygienic conditions along with warfare facilitate the occurrence of numerous diseases and body injuries not only among the local people but also among peacekeepers, who represent the population of immigrants. Health hazards which pose major epidemiological threats in combat zones are arthropod-borne, food and water-borne, respiratory tract diseases, sexually transmitted diseases, enzootic diseases, battle injuries, and non- -battle injuries, e.g. traffic accidents. Another considerable health problem are psychiatric disorders, which can either appear directly after the occurrence of a traumatic event in a combat zone or indirectly, after some time had elapsed. In addition to the health hazards listed above, environmental factors such as changeable weather conditions and local fauna may also be life threatening.
Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. (1987)

The rRNA intervening sequence of Tetrahymena is a catalytic RNA molecule, or "ribozyme." A tertiary-structure model of the active site of this ribozyme has been constructed based on comparative sequence analysis of related group I intervening sequences, data on the accessibility of each nucleotide to chemical and enzymatic probes, and principles of RNA folding derived from a consideration of the structure of tRNA determined by x-ray crystallography. In the model, the catalytic center has a two-helix structural framework composed of the base-paired segments of the group I conserved sequence elements. The structural framework supports and orients the conserved nucleotides that are adjacent to the base-paired sequence elements; these conserved nucleotides are proposed to form the active site and to bind the 5' splice-site duplex and the guanine nucleotide substrate. Tests of the model are proposed.
Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. (1993)

c-Myc and Max are nuclear phosphoproteins capable of forming DNA-binding, homo- and heteropolymeric complexes in vitro and in vivo. Using a transient cotransfection assay involving c-Myc and Max expression vectors and a reporter gene plasmid containing the Myc/Max binding site, we find that Max represses transcription, whereas a significant stimulation is obtained when Max is coexpressed with c-Myc. Analysis of specific mutants indicates that transcriptional activation requires both the c-Myc and the Max dimerization and DNA-binding domains, as well as the c-Myc transactivation function; transcriptional repression by Max requires both DNA binding and dimerization. Analogously, in stably transfected human B-lymphoblastoid cell lines, overexpressed c-Myc and Max synergize to cause malignant transformation, whereas overexpression of Max alone leads to growth inhibition. These results indicate that the c-Myc and Max are transcriptional regulators with the ability to oppositely regulate target-gene expression and cell proliferation, most likely as the result of the opposite effects of heterodimeric c-Myc-Max (positive) versus homodimeric Max (negative) complexes.
In Vitro Activity of 19 Antimicrobial Agents against Enterococci from Healthy Subjects and Hospitalized Patients and Use of an ace Gene Probe from Enterococcus faecalis for Species Identification (2001)

We tested 165 enterococcal isolates, biased toward vancomycin resistant (VR) isolates, collected during recent years from fecal samples of healthy subjects and clinical specimens of hospitalized patients (mostly from United States and some from Europe) for susceptibility to 19 antimicrobials. Nosocomial isolates, whether VR or not, were more often highly resistant to aminoglycosides and clindamycin than fecal isolates from healthy community volunteers and more often resistant to erythromycin, chloramphenicol, trimethoprim, levofloxacin and, for E. faecium, ampicillin (93 vs. 0%). Resistance rates were similar between nosocomial and community-fecal isolates for minocycline, rifampin and quinupristin-dalfopristin (Q-D). None of the 165 enterococci tested hybridized with aph(2'')-Ic and aph(2'')-Id probes for recently described gentamicin resistance genes and 37 of the 39 isolates with high level resistance (HLR) to gentamicin hybridized with an intragenic aac(6')-aph(2'') probe. Of the two newer drugs tested, daptomycin MIC90s were 0.25 microg/mL for E. faecalis and 1 microg/mL for E. faecium, regardless of their vancomycin resistance level or source. For Q-D, none of 28 E. faecium from community based healthy subjects in the USA and 7 of 66 E. faecium from hospitalized patients in the United States were resistant. Among these 7 Q-Dr United States isolates and 7 Q-Dr isolates from Europe (MICs of Q-D of 4-8 microg/mL), none hybridized with vat(D) (formerly satA) and vat(E) (formerly satG) DNA probes, indicating the involvement of other mechanism/s of resistance in these isolates. We also demonstrated that an intragenic probe of the gene ace from E. faecalis showed specific hybridizations to all E. faecalis isolates, suggesting the usefulness of this gene for identification of this species.
Long-range spiralling surface plasmon modes on metallic nanowires (2008)

We discuss the characteristics of surface plasmon modes guided on metallic nanowires of circular cross-section embedded in silica glass. Under certain conditions such wires allow low-loss guided modes, full account being taken of ohmic losses in the metal. We find that these modes can be bound to the wire even when the real part of their axial refractive index is less than that of the surrounding dielectric. We assess in detail the accuracy of a simple model in which SPs are viewed as spiralling around the nanowire in a helical path, forming modes at certain angles of pitch. The results are relevant for understanding the behavior of light in two-dimensional arrays of metallic nanowires in fiber form.
Atlas of Endoscopic Spine Surgery (1995)

PART 1 GENERAL PRINICPLES of THORACOSCOPY and LAPAROSCOPY: Evolution of Minimally Invasive Surgery: Thoracoscopy and Laparoscopy, Spinal Endoscopy, Video-Assisted Spinal Surgery: Laboratory Protocol. Anesthetic Considerations: Thoracoscopy, Laparoscopy. Equipment and Instrumentation for Thoracoscopy and Laparoscopy. Basic Concepts and Operative Planning: Thoracoscopic Surgery, Laparoscopic Discectomy. Training and Credentialing. PART II FUNDAMENTALS of ENDOCOPIC SPINE SURGERY: Indications and Contraindications. Equipment and Instrumentation for Endoscopic Spine Surgery. Complications. Anatomy and Exploration: Thoracoscopic Anatomy of the Spine, Laparoscopic Anatomy of the Lumbar Spine PARTIII SURGICAL TECHNIQUES: Endoscopic Approach Strategies. Approach to the Lumbar Spine Without Insufflation. Biopsy of Discs, Vertebrae, And Paraspinal Mass. Thoracic Discectomy and Fusion Commentary. Thoracolumbar Spinal Corpectomy. Adult Spinal Deformity. Pediatric Spinal Deformity: Pediatric Thoracoscopic Spinal Surgery, Alternative Technique for Thoracoscopic Releases in Pediatric Patients, Commentary. Thoracolumbar Discectomy. Laparoscopic Lumbar Retroperitoneal and Transperitoneal Discectomy Commentary. Arthroscopic Microdiscectomy. Posterolateral Approach. Lumbosacral (L5-S1) Discectomy and Interbody Fusion Technique. Spinal Instrumentation : the Bagby and Kuslich (BAK) System of Spinal Stabilization, Laparoscopic Fusion and BAL Stabilization of the Lumbar Spine, Endoscopic Applications of the BAK System. Newer Applications of Spinal Instrumentation: Endoscopic Internal Fixation of the Thoracic Spine, Artificial Discs, Endoscopic Approach to the Lumbar Spine Using the Insufflation Technique, Endoscopic Thoracic Fusion Cage
Ventilatory pattern and associated episodic hypoxaemia in the late postoperative period in the general surgical ward (1999)

Episodic oxygen desaturation is frequent in the late postoperative period and seems most pronounced on the second and third postoperative nights. However, the ventilatory pattern has not been described systematically during this period. We studied the ventilatory pattern and associated arterial oxygenation using the Edentrace II equipment (impedance pneumography and pulse oximetry) on the second and third postoperative nights in 28 patients undergoing major abdominal surgery. Ventilatory disturbances were common and included periods of hypopnoea, and obstructive, central and mixed apnoeas. Overall, the median (range) respiratory disturbance index (apnoeas + hypopnoeas per h) was 12 (0-121), with the patients spending 6% (0-65%) of the night in some kind of ventilatory disturbance. It was not possible from pre-operative snoring habits to predict patients who developed postoperative ventilatory disturbances. Overall, 23% (0-100) of the hypopnoeas and 7% (0-100) of the apnoeas were associated with episodic hypoxaemia. In conclusion, ventilatory disturbances were common in the late postoperative period in the general surgical ward and often associated with episodes of oxygen desaturation.
Vascular endothelial growth factor, FLT‐1, and FLK‐1 analysis in a pancreatic cancer tissue microarray (2006)

VEGF and its 2 principal receptors were expressed to varying degrees in tumors of the pancreas. A significant association was found between low expression of FLT-1 and both poor prognosis and advanced stage, suggesting that tumor expression of this VEGF receptor is a marker of less aggressive disease.
MECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy (2009)

MeP vectors recapitulate the endogenous expression pattern of MeCP2 in neurons and glia. They have utility to study MeCP2 isoform-specific functions in vitro, and are effective gene therapy vectors for rescuing dendritic maturation of neurons in an ex vivo model of RTT.
Allelotype of human ovarian cancer. (1991)

In order to determine which chromosome(s) carries a tumor suppressor gene(s) for human ovarian cancer, we examined loss of heterozygosity in 37 tumors with a set of polymorphic DNA markers which cover each autosomal chromosome arm partially. Frequent losses were observed in chromosomes 4p (42%), 6p (50%), 7p (43%), 8q (31%), 12p (38%), 12q (33%), 16p (33%), 16q (38%), 17p (46%), 17q (39%), and 19p (34%). In addition to these chromosomes, frequent losses of alleles on chromosomes 6q, 13q, and 19q were observed uniquely in serous and serous papillary cystadenocarcinomas; loss of heterozygosity was detected only rarely on these chromosomal arms in nonserous types of tumors. The average (0.12) of fractional allelic loss seen in mucinous cystadenocarcinoma, which usually has a better prognosis than other types, was much lower than that of other tumor phenotypes including serous cystadenocarcinoma (0.31) and clear cell carcinoma (0.20). These results suggested that (a) a large number of tumor suppressor genes might play a role in ovarian cancer, (b) losses of alleles in different chromosomal regions could account for differences in histopathological features and/or prognoses among patients, and (c) this kind of analysis can contribute to an improved understanding of tumor development and/or progression in human ovarian cancer.
Lipopolysaccharide Inhibits HIV-1 Infection of Monocyte- Derived Macrophages Through Direct and Sustained Down-Regulation of CC Chemokine Receptor 5 (2000)

Abstract It is now well established that HIV-1 requires interactions with both CD4 and a chemokine receptor on the host cell surface for efficient infection. The expression of the CCR5 chemokine receptor in human macrophages facilitates HIV-1 entry into these cells, which are considered important in HIV pathogenesis not only as viral reservoirs but also as modulators of altered inflammatory function in HIV disease and AIDS. LPS, a principal constituent of Gram-negative bacterial cell walls, is a potent stimulator of macrophages and has been shown to inhibit HIV infection in this population. We now present evidence that one mechanism by which LPS mediates its inhibitory effect on HIV-1 infection is through a direct and unusually sustained down-regulation of cell-surface CCR5 expression. This LPS-mediated down-regulation of CCR5 expression was independent of de novo protein synthesis and differed from the rapid turnover of these chemokine receptors observed in response to two natural ligands, macrophage-inflammatory protein-1α and -1β. LPS did not act by down-regulating CCR5 mRNA (mRNA levels actually increased slightly after LPS treatment) or by enhancing the degradation of internalized receptor. Rather, the observed failure of LPS-treated macrophages to rapidly restore CCR5 expression at the cell-surface appeared to result from altered recycling of chemokine receptors. Taken together, our results suggest a novel pathway of CCR5 recycling in LPS-stimulated human macrophages that might be targeted to control HIV-1 infection.
The Use of Entropy Labels in MPLS Forwarding (2012)

Load balancing is a powerful tool for engineering traffic across a
network. This memo suggests ways of improving load balancing across
MPLS networks using the concept of labels. It defines the
concept, describes why entropy labels are useful, enumerates
properties of entropy labels that allow maximal benefit, and shows how
they can be signaled and used for various applications. This document
updates RFCs 3031, 3107, 3209, and 5036. [STANDARDS-TRACK]
The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances* (1990)

The presence of corticosteroid-binding globulin (CBG) in plasma was detected about 30 yr ago, and of sex hormone-binding globulin (SHBG) about 20 yr ago. In the interval since their discovery, sophisticated binding and RIAs have been devised for their measurement; their concentrations in plasma and other biological fluids, from milk to saliva, have been measured in myriad clinical conditions in humans, and numerous experimental ones in animals; their phyletic distribution has been examined; they have been isolated and their complementary DNAs (cDNAs) cloned; their binding specificities for steroids have been examined in heroic detail; hormonal and drug influences on their plasma concentration in vivo, and their secretion by liver cells in vitro, have been widely explored; they have been the subject of two long, splendid monographs (1, 2) and many shorter reviews (3–11) [wherein the original citations for the first part of this sentence may be found]—and yet we still have not come to a consensus on what it is that they do. Undeniably, they bind certain steroids. But to what biological end?
Numerical Simulation of TUNNETT and MITATT Devices in the Millimeter and Submillimeter Range (1993)

Abstract — Numerical simulation programs for two-terminal transit-time devices based on drift-diffusion and energy-momentum transport models, with valence band to conduction band tunneling incorporated, have been developed. These programs can deliver accurate TUNNETT and MITATT device simulation results in the millimeter and submillimeter range. As the simulation results show, while the energy-momentum program is more accurate in the higher frequency range, the drift-diffusion program, which demands less computer resources, is suitable for W band devices.
Exploring architectures for volume visualization on the Teramac custom computer (1996)

In the past year we have gained experience in custom computing by porting a number of large applications to Teramac. Teramac is a custom computer capable of executing million-gate user designs at speeds approaching one megahertz. Teramac includes software that fully automates the conversion of high-level user designs to configurations that are ready to run on Teramac. Two applications, both in excess of a quarter million gates, are described here: an artery-extraction filter that locates and highlights arteries in medical MRI datasets; and Cube, a volume-rendering engine. We have discovered the importance of scalable, parameterized designs. We have been successful in parameterizing some aspects of our designs and we have identified improvements to our tools which would facilitate further parameterization. Our users have benefitted from the speed at which their applications run on Teramac and have gained confidence in their designs after seeing them run on actual hardware.
Editor's Corner (1997)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest (2011)

These preliminary data suggest that (18)F-labeled BMS747158 appears to be well tolerated and has a unique potential for myocardial perfusion PET.