gebhart/patrepeval huggingface dataset:
Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. (1988)

The immunologic responses to anti-T4 and anti-T11 mAb infusions were assessed in subjects with chronic progressive multiple sclerosis as part of phase I clinical studies. Eight subjects received five daily infusions (0.2 mg/kg/day) of either anti-T11 (CD2) or anti-T4 (CD4) murine mAb. It was found that in vivo anti-T cell mAb infusions specifically suppress in vitro measurements of the human immune response; anti-T11 mAb blocked T cell activation via the CD2 SRBC-binding protein, and anti-T4 mAb infusions abolished PWM-induced Ig synthesis without lysis of the CD4+ T cell subpopulations. With repeated infusions of the anti-T11 mAb in three subjects, anti-mouse antibodies were found in the circulation. Although the majority of human anti-mouse antibody was not isotype specific, significant anti-idiotypic-like activity was observed after repeated infusions in two of three subjects. The human anti-mouse antibodies were almost exclusively of the IgG isotype. The magnitude of the human anti-mouse response was significantly less after administration of either anti-T11 or anti-T4 as compared with anti-T12 mAb. Murine anti-T cell mAb can provide a specific, benign form of acute immunosuppression in humans. However, repeated administration of these reagents in more chronic diseases can result in anti-Id-like antibodies that block binding of the anti-T cell mAb to the T cell surface.
Bispecific molecules directed to the Fc receptor for IgA (Fc alpha RI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood. (1998)

The FcR for IgA (Fc alpha RI, CD89) is primarily expressed on cytotoxic immune effector cells. By chemically cross-linking F(ab') fragments of the FcR for IgA (Fc alpha RI)-specific mAb (A77) with tumor Ag-specific mAb (anti-HER2/neu and anti-epidermal growth factor receptor), we have developed bispecific molecules (BSM) that simultaneously bind to respective tumor Ags and Fc alpha RI-expressing effector cells in whole blood. These BSM mediated up to 55% of specific lysis of appropriate tumor Ag-expressing target cells (from a variety of tumors) with purified polymorphonuclear leukocytes, monocytes, or whole blood effector cells without preactivation with exogenous cytokines. To our knowledge, this is the first demonstration of Ab-dependent cell-mediated cytotoxic activity via Fc alpha RI in whole blood. Also, monocyte-derived macrophages mediated phagocytosis of HER2/neu-expressing tumor cells (>95% tumor cell loss). These BSM-mediated cytotoxic activities were completely inhibited by F(ab')2 of A77, demonstrating the specific role of Fc alpha RI as a trigger molecule. Furthermore, the binding of these BSM to monocytes or polymorphonuclear leukocytes in whole blood did not induce modulation of Fc alpha RI in the absence of the target Ag. Therefore, immune effector cells may be "armed" with Fc alpha RI-directed BSM in whole blood. These Fc alpha RI-directed BSM may offer new treatment options for various malignancies and other disease conditions.
Tamsulosin 0.4 MG once daily: 2-year follow-up efficacy & safety in 516 symptomatic BPH patients (1997)

SCOPUS: ar.j
EGFR-mediated cell cycle regulation. (2002)

Cancer is a disease of uncontrolled cell proliferation. The cell cycle provides a crucial platform for coordination between proliferation and cell death. Somatic cells undergo replication and division by traversing the tightly regulated cell cycle. Growth factors play a critical role in initiating signaling events stimulating cell cycle progression, which is crucial for their mitogenic and tumorigenic effects. Epidermal growth factor receptor (EGFR) and its ligands are frequently upregulated in human cancers. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion, and metastasis. Specific abrogation of EGFR results in cell cycle arrest, apoptosis, or dedifferentiaton of cancer cells. Downregulation of EGFR signaling has therapeutic benefit in preclinical and clinical studies. Therefore, better understanding of the mechanisms of regulation and coordination between the cell cycle, cell growth, and cell death will lead to the development of novel cancer therapies.
A class of frequency hop codes with nearly ideal characteristics for multiple-target recognition (2002)

The problem of construction of a code sequence with good auto- and cross-correlation properties for multiple access communications has received a lot of attention. M-sequences and sequences derived from them solve the problem in the one dimensional space. However, the problem of sequence construction becomes much more complicated when extended to two dimensions as is the case in (1) multiuser radar and sonar systems, and (2) FH-CDMA mobile radio. We introduce new families of FH codes whose construction is not limited to GF(p) but remains valid for GF(p/sup n/). The codes are in fact a cross between the so called Lempel-Golomb (1984) constructions for Costas arrays and various families of n-th order congruence codes. We also describe their 2-D auto- and cross-correlation properties. Our construction produces families of FH codes that falls in what are called extended sonar and Costas sequence.
Session 7: Demonstrations. (1994)

Jack Mostow, fzom CMU, began the evening by showing a prototype reading coach designed to help children read by listening to them reading aloud. The system follows along as the student reads, detecting when words are not read correctly or when the reader gets stuck. Reading disfluencies are evaluated by a rulebased pedagogical evaluation component, which chooses appropriate interventions to help the reader. These interventions include asking the reader to re-read a word or a phrase, pronouncing a difficult word to the reader, ignoring the error, giving the reader a chance to correct the mis-reading in the context of a fluent reading of the initial part of the sentence, and reading the whole phrase to the reader. The system currently runs on a combination of DEC-Alpha and NeXT computers, with adult voices reading and mis-reading children's stories.
Hybrid spatiotemporal architectures for universal linear optics (2019)

We present two hybrid linear-optical architectures that simultaneously exploit spatial and temporal degrees of freedom of light to effect arbitrary discrete unitary transformations. Our architectures combine the benefits of spatial implementations of linear optics, namely, low loss and parallel operation, with those of temporal implementations, namely, modest resource requirements and access to transformations of potentially unbounded size. We arrive at our architectures by devising and employing decompositions of large discrete unitary transformations into smaller ones, decompositions we expect to have broad utility beyond spatiotemporal linear optics. We show that hybrid architectures promise important advantages over both spatial-only and temporal-only architectures.
The N‐terminal globular domain of the laminin α1 chain binds to α1β1 and α2β1 integrins and to the heparan sulfate‐containing domains of perlecan (1998)

The N-terminal domains VI plus V (62 kDa) and V alone (43 kDa) of the laminin alpha1 chain were obtained as recombinant products and shown to be folded into a native form by electron microscopy and immunological assays. Domain VI alone, which corresponds to an LN module, did not represent an autonomously folding unit in mammalian cells, however. Fragment alpha1VI/V, but not fragment alpha1V, bound to purified alpha1beta1 and alpha2beta1 integrins, to heparin, and to heparan sulfate-substituted domains I and V of perlecan. This localized the binding activities to the LN module, which contains two basic sequences suitable for heparin interactions.
Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor (2005)

We have previously shown that the HDAC inhibitors (HDACI) activate the p53 molecule through acetylation of 320 and 373 lysine residues, upregulate PIG3 and NOXA and induce apoptosis in cancer cells expressing wild and pseudo-wild type p53 genes (Terui T, et al. Cancer Res 2003; 63:8948-54). It has also been reported that expression of the Coxsackie adenovirus receptor and subsequent transfection efficiency of the adenovirus in cancer cells were enhanced by HDACI treatment. In this study, we extended these observations to explore the combination effect of adenoviral vector carrying wild type p53 (Ad-p53) gene therapy with a HDACI, sodium butyrate (SB), on xenografted human gastric cancer cells (KATO-III) and hepatocellular carcinoma cells (HuH7) in nude mice. We first confirmed an increased expression of Coxsackie adenovirus receptors with an associated increment of transgene (X-gal) expression by SB treatment in KATO-III cells. We then injected Ad-p53 into subcutaneous tumors of KATO-III and HuH7 combined with intraperitoneal administration of SB and found a significantly higher growth suppressive effect than single treatments of each. Even a complete regression of tumors was observed in three of five mice treated with this combination while with single treatment no tumor regression was observed. Tumors treated with the combination showed higher numbers of TUNEL positive cells than those treated with a single modality. Moreover, necrotic changes were more evident in tumors treated with the combination than separately, a compatible finding to the observation that vascularity revealed by CD34 staining was poorer in tumors treated with the combination than those treated with p53 gene or SB alone. This was further supported by the finding that BAI-1 (brain specific angiogenesis inhibitor-1), an inhibitor of vascularization, was induced by SB treatment in KATO-III and HuH7 cells transfected with Ad-p53. Thus SB was shown to be an efficient potentiator of p53 gene therapy for cancer.
Image-Based Motion Compensation for Structured Light Scanning of Dynamic Surfaces (2008)

Structured light scanning systems based on temporal pattern codification produce dense and robust results on static scenes but behave very poorly when applied to dynamic scenes in which objects are allowed to move or to deform during the acquisition process. The main reason for this lies in the wrong combination of encoded correspondence information because the same point in the projector pattern sequence can map to different points within the camera images due to depth changes over time. We present a novel approach suitable for measuring and compensating such kind of pattern motion. The described technique can be combined with existing active range scanning systems designed for static surface reconstruction making them applicable for the dynamic case. We demonstrate the benefits of our method by integrating it into a gray code based structured light scanner, which runs at thirty 3d scans per second.
One-Step, Nanoparticle-Mediated Bacterial Detection with Magnetic Relaxation (2006)

Acknowledging the need for the development of fast and sensitive bacterial detection methods, we functionalized superparamagnetic iron oxide nanoparticles to identify Mycobacterium avium spp. paratuberculosis (MAP), through magnetic relaxation. Our results indicate that the MAP nanoprobes (1) bind specifically to MAP, (2) can quantify the bacterial target quickly in milk and blood with high sensitivity, and (3) are not susceptible to interferences caused by other bacteria. The use of the described magnetic nanosensors in the identification and quantification of bacteria in clinical and environmental samples is anticipated.
Scan performance of infinite arrays of microstrip patch elements loaded with varactor diodes (1993)

The analysis and scanning characteristics of an infinite array of rectangular microstrip patches each loaded with a varactor diode is presented. The analysis is based on full-wave moment method theory and uses attachment modes to accurately model the current through the feed and the diode. The effect of the biased varactor diode on the scan performance is presented, and it is shown that the impedance mismatch caused by a scan blindness can be eliminated. Other characteristics are also given such as: the active element gain, the efficiency of each loaded microstrip element, and the level of cross polarization generated by the loading of the patch. The effect of the diode biasing level as well as the position of the diode on each radiating element on these scan characteristics is also considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Improving table compression with combinatorial optimization (2003)

We study the problem of compressing massive tables within the partition-training paradigm introduced by Buchsbaum et al. [2000], in which a table is partitioned by an off-line training procedure into disjoint intervals of columns, each of which is compressed separately by a standard, on-line compressor like gzip. We provide a new theory that unifies previous experimental observations on partitioning and heuristic observations on column permutation, all of which are used to improve compression rates. Based on this theory, we devise the first on-line training algorithms for table compression, which can be applied to individual files, not just continuously operating sources; and also a new, off-line training algorithm, based on a link to the asymmetric traveling salesman problem, which improves on prior work by rearranging columns prior to partitioning. We demonstrate these results experimentally. On various test files, the on-line algorithms provide 35--55% improvement over gzip with negligible slowdown; the off-line reordering provides up to 20% further improvement over partitioning alone. We also show that a variation of the table compression problem is MAX-SNP hard.
Expression of serine threonine kinase 15 is associated with poor differentiation in lung squamous cell carcinoma and adenocarcinoma (2006)

Serine threonine kinase 15 (STK15, also named BTAK, Aurora-A, aurora-2, or AIKI) is a type of mitotic kinase. The overexpression of STK15 is significantly associated with carcinogenesis in many tumors. The purpose of the present study was to investigate the expression of STK15 in lung squamous cell carcinoma and adenocarcinoma and analyze the correlation between STK15 expression and clinicopathological factors. The expression patterns of STK15 were examined by immunohistochemistry in 80 lung squamous cell carcinomas and adenocarcinomas and 20 normal lung tissues. The protein and mRNA expression of STK15 were evaluated by western blot and reverse transcription-polymerase chain reaction (RT-PCR) in 40 lung cancer samples and corresponding normal lung tissues. Immunohistochemically, the positivity of STK15 expression was 68.75% (55/80). The STK15 expression was significantly higher in poorly differentiated lung cancers than in well-differentiated or moderately differentiated lung cancers (P = 0.011). Western blot and RT-PCR showed that the protein and mRNA expression of STK15 were correlated (P = 0.044) and significantly higher in tumors than in corresponding normal lung tissues (P < 0.05). These results indicate that the overexpression of STK15 contributes to the carcinogenesis and de-differentiation of lung cancers.
A controlled double blind study of azathioprine in the management of Crohn??s disease (1995)

European Journal of Gastroenterology & Hepatology: December 1995 - Volume 7 - Issue 12 - p 1232
HDL-based modeling of embedded processor behavior for retargetable compilation (1998)

The concept of retargetability enables compiler technology to keep pace with the increasing variety of domain-specific embedded processors. In order to achieve user retargetability, powerful processor modeling formalisms are required. Most of the recent modeling formalisms concentrate on horizontal, VLIW-like instruction formats. However, for encoded instruction formats with restricted instruction-level parallelism (ILP), a large number of ILP constraints might need to be specified, resulting in less concise processor models. This paper presents an HDL-based approach to processor modeling for retargetable compilation, in which ILP may be implicitly constrained. As a consequence, the formalism allows for concise models also for encoded instruction formats. The practical applicability of the modeling formalism is demonstrated by means of a case study for a complex DSP.
Peptides : chemistry and biology : proceedings of the twelfth American Peptide Symposium, June 16-21, 1991, Cambridge, Massachusetts, U.S.A. (1992)

These proceedings of the Twelfth American Peptide Symposium include 363 articles which were selected for publication on the basis of originality, timeliness and scientific significance. This volume includes contributions on ppetide hormones, neuropeptides, lipid-interactive peptides, peptide and protein conformation, de novo design, structure-activity relationships, synthetic methods, large-scale peptide synthesis, viruses and vaccines, peptide mimetics, peptide inhibitors, immunology and new biologically active peptides.
Source localization in shallow water in the presence of sensor location uncertainty (2000)

The problem of source localization in shallow water in the presence of sensor location uncertainty is considered. The Cramer-Rao Bound is used to carry out a feasibility study for the joint source and sensor location problem when the multipath propagation channel is modeled as a known, deterministic waveguide. Unlike the free-space propagation channel, the boundedness of the shallow-water waveguide along its vertical axis provides the key to joint determination of the source and sensor location parameters. It is seen that, when a set of intuitive identifiability conditions are satisfied, numerical examples indicate that, for the scenarios considered, the resulting loss in accuracy with which the source location can be estimated due to sensor location uncertainty may be tolerable.
Quantum cryptography in free space (1996)

The range of quantum cryptography systems using optical fibers is limited to roughly 30 km because amplifiers cannot be used. A fully operational system for quantum cryptography based on the transmission of single photons in free space under daylight conditions has been demonstrated. The feasibility of a global system for quantum cryptography based on a network of ground stations and satellites is discussed.
Holonomic Quantum Computation in Subsystems (2009)

We introduce a generalized method of holonomic quantum computation (HQC) based on encoding in subsystems. As an application, we propose a scheme for applying holonomic gates to unencoded qubits by the use of a noisy ancillary qubit. This scheme does not require initialization in a subspace since all dynamical effects factor out as a transformation on the ancilla. We use this approach to show how fault-tolerant HQC can be realized via 2-local Hamiltonians with perturbative gadgets.
Stealth「上○R上」 liposomes (1995)

Introduction, D.D. Lasic and F.J. Martin Foreword, A.D. Bangham Stealth(R) Liposomes: From Steric Stabilization to Targeting, D. Papahadjopoulos Fate of Liposomes In Vivo and Its Control: An Historical Perspective, G. Gregoriadis Effect of Surface Modification with Glycolipids and Polysaccharides on In Vivo Fate of Liposomes, P.C. Ghosh and B.K. Bachhawat Stabilization of Colloidal Dispersions by Grafted Polymers, O. Borisov, P. Auroy, and L. Auvray Physical Properties of Polymer-Grafted Bilayers, K. Hristova and D. Needham Molecular Mechanism of Liposome and Immunoliposome Steric Protection with Poly (Ethylene Glycol): Theoretical and Experimental Proofs of the Role of Polymer Chain Flexibility, V.P. Torchilin, M.I. Papisov, A.A. Bogdanov, V.S. Trubetskoy, and V.G. Omelyanenko Measurement of the Range and Magnitude of the Repulsive Pressure between PEG-Coated Liposomes, T.J. McIntosh, A.K. Kenworthy, and D. Needham Modulation and Modeling of Interaction Forces between Lipid Bilayers Exposing Terminally Grafted Polymer Chains, T.L. Kuhl, D.E. Leckband, D.D. Lasic, and J.N. Israelachvili Polyetheylene Glycol-Lipid Conjugates, S. Zalipsky Biological Properties of Sterically Stabilized Liposomes, M.C. Woodle, M.S. Newman, and P.K. Working Mechanism of Stealth(R) Liposomes Accumulation in Some Pathological Tissues, S.K. Huang, F.J. Martin, D.S. Friend, and D. Papahadjopoulos Extravasation of Stealth(R) Liposomes into Tumors: Direct Measurement of Accumulation and Vascular Permeability Using a Skin-Flap Window Chamber, M. Dewhirst and D. Needham Pharmacokinetics and Antitumor Activity of Anthracyclines Precipitated in Sterically Stabilized (Stealth(R)) Liposomes, D.D. Lasic Tissue Uptake and Therapeutic Effects of Stealth(R) Doxorubicin, J. Vaage and E. Barbera Therapeutic Application of Vincristine in Conventional and Sterically Stabilized Liposomes, P.S. Uster Stealth(R) Liposomes as a Drug Sustained Release System for 1-b-D-Arabinosylfuranosylcytosine (Cytosine Arabinoside), T.M. Allen Stealth(R) Liposomes as Carriers of Antibiotics in Infectious Diseases, I. Bakker-Woudenberg, G. Storm, and M.C. Woodle Sterically Stabilized Liposome-Encapsulated Hemoglobin, S. Zheng, Y. Zheng, and R. Beissinger PEG-Modified Liposomes for Gamma-II and Magnetic Resonance Imaging, V.P. Torchilin, J. Narula, B.A. Khaw, and V.S. Trubetskoy Antibody-Targeted Stealth(R) Liposomes, T.M. Allen, C.B. Hansen, and S. Zalipsky Doxorubicin Encapsulated in Polyethylene-Glycol Coated Liposomes: Initial Clinical-Pharmacokinetic Studies in Solid Tumors, A. Gabizon, A. Huang, F. Martin, and Y. Barenholz Pharmacokinetics and Tumor Localization of DOX-SL (Stealth(R) Liposomal Doxorubicin) by Comparison with Adriamycin in Patients with AIDS and Kaposi Sarcoma, D. Northfelt, L. Kaplan, J. Russell, and P. Volberding Efficacy of DOX-SL (Stealth(R) Liposomal Doxorubicin) in the Treatment of Advanced AIDS-Related Kaposi Sarcoma, J.R. Bogner and F.D. Goebel
Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction (1990)

1. Interactions between the effects of adenosine or 2-chloro-adenosine (CADO) and the effects of substances that interfere with the phosphoinositides/protein kinase C transducing system or with the adenylate cyclase transducing system, on endplate potentials (e.p.ps), were investigated. The preparation used was the innervated sartorius muscle of the frog in which twitches had been prevented with high magnesium concentrations. 2. The activator of protein kinase C, 4 beta-phorbol-12,13-diacetate (PDAc), reversibly increased the amplitude and the quantal content of e.p.ps and attenuated the inhibitory effects of adenosine and CADO on e.p.p. amplitude. The affinity of the adenosine receptor antagonist, 8-phenyltheophylline, was not modified by PDAc. 3. The phorbol ester 4 alpha-phorbol-12,13-didecanoate, which does not activate protein kinase C, did not modify either e.p.p amplitude or the inhibitory effect of adenosine on e.p.ps. 4. The inhibitor of protein kinase C, polymyxin B, reversibly decreased the amplitude and the quantal content of e.p.ps, prevented the enhancement caused by PDAc on e.p.p. amplitude, but did not modify the inhibitory effect of adenosine on e.p.ps. H-7, another inhibitor of protein kinases, also decreased e.p.p. amplitude but did not modify the effect of PDAc on the amplitude of e.p.ps. 5. Lithium chloride, which alters phosphoinositide signal transduction by inhibiting the breakdown of inositol phosphates, reversibly increased the amplitude and the quantal content of the e.p.ps. In the presence of adenosine or CADO the effect of lithium on e.p.p. amplitude was markedly attenuated. 6. The activator of adenylate cyclase, forskolin, reversibly increased the amplitude and the quantal content of the e.p.ps. 7. The results suggest that the phosphoinositides/protein kinase C transducing system, but not the adenylate cyclase transducing system, might be involved in the inhibitory effect of adenosine on neuromuscular transmission.