gebhart/patrepeval huggingface dataset:
Evaluation of a proposed therapeutic protocol in 12 dogs with tentative degenerative myelopathy (2008)

The objective of this work was to evaluate the long-term efficacy of a proposed therapeutic protocol in 12 dogs with a tentative diagnosis of degenerative myelopathy, followed-up for a 6-month period. Twelve dogs fulfilling the antemortem inclusion criteria (breed, age, adequate vaccination, history of progressive posterior ataxia and/or paraparesis, no radiographic and myelographic abnormalities in the spinal cord and vertebral column) were allocated. All these dogs presented signs of thoracolumbar syndrome (T3-L3), scored as grade I (mild to moderate ataxia and paraparesis) in 10 and grade II (severe ataxia and ambulatory paraparesis) in 2 cases. Treatment included the use of epsilon-aminocaproic acid and N-acetylcysteine, supplemented with vitamins B, C and E. Prednisolone was given for the first two weeks and upon worsening of neurological signs. Daily exercise, performed as walking or swimming, was strongly recommended. Clinicopathological evaluation was normal in all 12 dogs, and survey radiographs and myelograms did not show spinal cord compression. Magnetic resonance imaging (MRI), performed only in 4 dogs, did not disclose compressive disorders or intramedullary lesions. Neurological signs were progressively worsening in all 12 animals, eventually resulting in severe paraparesis (grade III) or paraplegia (grade IV). The applied medications do not appear to be an attractive alternative to conservative management (physiotherapy) or euthanasia in canine degenerative myelopathy, irrespective of its chronicity.
Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells. (1992)

Interferon gamma (IFN-gamma), a lymphokine that exerts multiple immunoregulatory effects, has been found to be elevated in the plasma, cerebrospinal fluid, and lymph nodes of human immunodeficiency virus (HIV)-infected individuals and has shown variable effects on HIV replication in acutely infected cells. In the present study, we have demonstrated that IFN-gamma is a potent modulator of HIV expression in persistently infected U1 promonocytic cells in which virus production is characterized by a constitutive state of relative latency. Direct stimulation of U1 cells with IFN-gamma (10-1,000 U/ml) activated HIV expression, as measured by reverse transcriptase (RT) activity in the culture supernatant and increased levels of cell-associated viral protein and mRNAs. These effects on virus expression were not accounted for by the induction of endogenous TNF-alpha secretion, as previously described in U1 cells stimulated with phorbol myristate acetate (PMA). At the ultrastructural level, the stimulatory activity of IFN-gamma was correlated with HIV particle production in intracytoplasmic vacuoles along with the differentiation of U1 into macrophage-like cells. Furthermore, costimulation of U1 cells with IFN-gamma and PMA significantly increased the accumulation of vacuole-associated HIV concomitant with decreasing membrane-associated particles and RT activity production, as compared with cells stimulated with PMA alone. No evidence of spontaneous secretion of intracellular vacuole-associated virus was obtained by kinetic analysis of the RT activity released in the supernatants throughout the culture period unless cells were deliberately disrupted. These findings suggest that vacuole-associated virions likely represent a relatively stable intracellular reservoir of HIV, as previously described in primary macrophages infected in vitro or in infected macrophages in the brains of patients with acquired immune deficiency syndrome. The reduced levels of RT activity observed in the culture supernatants of U1 cells stimulated with PMA in the presence of IFN-gamma were not indicative of a suppressive effect of IFN-gamma on PMA-induced expression of HIV proteins and mRNAs, either directly or mediated by the release of IFN-alpha/beta. This study suggests that IFN-gamma may play an important role as an inducer of HIV expression in infected mononuclear phagocytes.
Neonatal Ventilation With Inhaled Nitric Oxide Versus Ventilatory Support Without Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure: The INNOVO Multicentre Randomised Controlled Trial (ISRCTN 17821339) (2005)

Evidence of prolongation of intensive care and increased costs of such care, without clear beneficial effects, implies that iNO cannot be recommended for preterm infants with severe hypoxic respiratory failure.
Human intestinal epithelial cells express functional cytokine receptors sharing the common gamma c chain of the interleukin 2 receptor. (1995)

Interleukin (IL) 2 signaling requires the dimerization of the IL-2 receptor beta (IL-2R beta) and common gamma (gamma c) chains. The gamma is also a component of the receptors for IL-4, IL-7, and IL-9. To assess the extent and role of the receptor signal transducing system utilizing the gamma c chain on human intestinal epithelial cells, the expression of gamma c, IL-2R beta, and receptor chains specific for IL-4, IL-7, and IL-9 was assessed by reverse transcription-coupled PCR on human intestinal epithelial cell lines and on isolated primary human intestinal epithelial cells. Caco-2, HT-29, and T-84 cells were found to express transcripts for the gamma c and IL-4R chains constitutively. IL-2R beta chain expression was demonstrated in Caco-2 and HT-29 but not in T-84 cells. None of the cell lines expressed mRNA for the IL-2R alpha chain. After stimulation with epidermal growth factor for 24 h Caco-2, HT-29, and T-84 cells expressed transcripts for IL-7R. In addition, Caco-2 and HT-29 cells expressed mRNA for the IL-9R. Receptors for IL-2, IL-4, IL-7, and IL-9 on intestinal epithelial cells lines appeared to be functional; stimulation with these cytokines caused rapid tyrosine phosphorylation of proteins. The relevance of the observations in intestinal epithelial cell lines for intestinal epithelial function in vivo was supported by the demonstration of transcripts for gamma c, IL-2R beta, IL-4R, IL-7R, and IL-9R in primary human intestinal epithelial cells.
Bevacizumab Has Differential and Dose-Dependent Effects on Glioma Blood Vessels and Tumor Cells (2011)

Regression of glioma cells can occur independently from vascular regression, suggesting that high doses of bevacizumab have indirect anticancer cell properties in vivo.
Observation of Saturn-Ring Defects around Solid Microspheres in Nematic Liquid Crystals (2000)

We report an experimental system based on rigid, monodisperse, microparticles with tunable surface properties for the study of topological defects that form about dispersed solid phases in anisotropic media. We clearly observe equatorial Saturn-ring defects to form a distance (0.09+/-0.01)R from the surface of isolated microspheres (with strong homeotropic anchoring) dispersed in nematic phases. These defects, some of which are observed to be stable for up to a month, are similar in size to past theoretical predictions (with strong homeotropic anchoring) and can be reversibly expanded in an electric field.
Investigations of oxygen reduction reactions in non-aqueous electrolytes and the lithium-air battery (2010)

Unlocking the true energy capabilities of the lithium metal negative electrode in a lithium battery has until now been limited by the low capacity intercalation and conversion reactions at the positive electrodes. This is overcome by removing these electrodes and allowing lithium to react directly with oxygen in the atmosphere forming the Li-air battery. The Li/O2 battery redox couple has a theoretical specific energy of 5200Wh/Kg and represents the ultimate energy density, environmentally friendly battery.
Doppler Radar Techniques for Vital Signs Detection Featuring Noise Cancellation (2019)

Remote or noncontact vital signs detection through microwave and millimeter-wave radar techniques based on micro-Doppler effects can find wide-ranged applications in healthcare and biomedical sectors. Although a significant research progress has been achieved, there are still numerous challenging issues that should be addressed for practical implementations such as random body movement (RBM) and radar self-motion (RSM) artifacts which significantly degrade the detection accuracy. To cancel noises caused by RBM and/or RSM, innovative hardware technologies and advanced signal processing methods should be devised and developed. This paper reviews the recent progress of Doppler radar systems for noncontact vital signs detection and measurements featuring RBM and RSM noise cancellation.
Three Dimensional Image Sensing, Visualization, and Processing Using Integral Imaging (2004)

We present a number of techniques for 3D image sensing, 3D visualization/display, and 3D image processing. These include computational synthetic aperture integral imaging, moving array lenslet technique, and computational integral imaging. These techniques increase resolution, depth of focus, the field of view, and the viewing angle of integral imaging systems.
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity (1997)

The CXCR-4 chemokine receptor and CD4 behave as coreceptors for cell line-adapted human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and for dual-tropic HIV strains, which also use the CCR-5 coreceptor. The cell line-adapted HIV-1 strains LAI and NDK and the dual-tropic HIV-2 strain ROD were able to infect CD4+ cells expressing human CXCR-4, while only LAI was able to infect cells expressing the rat homolog of CXCR-4. This strain selectivity was addressed by using human-rat CXCR-4 chimeras. All chimeras tested mediated LAI infection, but only those containing the third extracellular domain (e3) of human CXCR-4 mediated NDK and ROD infection. The e3 domain might be required for the functional interaction of NDK and ROD, but not LAI, with CXCR-4. Alternatively, LAI might also interact with e3 but in a different way. Monoclonal antibody 12G5, raised against human CXCR-4, did not stain cells expressing rat CXCR-4. Chimeric human-rat CXCR-4 allowed us to map the 12G5 epitope in the e3 domain. The ability of 12G5 to neutralize infection by certain HIV-1 and HIV-2 strains is also consistent with the role of e3 in the coreceptor activity of CXCR-4. The deletion of most of the amino-terminal extracellular domain (e1) abolished the coreceptor activity of human CXCR-4 for ROD and NDK but not for LAI. These results indicate that HIV strains have different requirements for their interaction with CXCR-4. They also suggest differences in the interaction of dual-tropic HIV with CCR-5 and CXCR-4.
Fabrication of composite materials from multilayered Al/Ti foils by pressure welding at room temperature. (1999)

In order to produce metal-matrix-composites by a simple method, it was attempted to fabricate Al/9.7 vol%Ti composite by pressing and by rolling after compression of alternately multilayered pure Al and Ti foils at room temperature. The formation process of Al/Ti composites was examined and tensile properties of the composites were measured. Tensile strength of the composites was compared with the values estimated from the rule of mixture on the flake reinforced composite. Joining of the multilayered Al/Ti foils is attained by nominal compressive stress from 0.5 to 2 GPa at room temperature. The obtained composites consist of dispersed Ti-flakes and Al matrix. The size of Ti-flakes becomes smaller with increasing compressive stress and reduction in cold rolling after compression. Nominal compressive stress of 1.0 GPa gives the highest tensile strength of the Al/Ti composites in the present work. Cold rolling with reduction of 70% after compression at 2 GPa gives lower tensile strength of the Al/ Ti composites than that without rolling.
The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location (1988)

We have used a transient expression system to examine the influence of the hepatitis B virus enhancer on the transcription of the hepatitis B virus surface antigen (HBsAg) gene. This enhancer is located 3' to HBsAg coding sequences but is contained within the mature HBsAg transcripts. Removal of the enhancer resulted in a significant reduction in HBsAg gene expression in liver cells. By using an in vitro nuclear run-on assay, this effect was determined to be at the level of transcription. We have further noted that HBsAg expression can be restored by the reinsertion of the enhancer sequences in the enhancerless vector. However, this reconstitution of HBsAg expression appears to depend on location of the enhancer with regard to the HBsAg promoters.
Design of On-Chip Transformer With Various Coil Widths to Achieve Minimal Metal Resistance (2007)

A layout design algorithm of a variable-width transformer is proposed to minimize metal resistance in this letter. The proposed algorithm can rapidly design metal widths in each coil of a planar transformer for a given chip area. Two on-chip transformers with identical self-inductance are fabricated to verify the proposed algorithm in 90-nm CMOS technology. Measurement results demonstrate the improvement of metal resistance approximates to the value of 11.6%. Results of this study provide an effective algorithm to design a minimal-loss transformer for radio frequency integrated circuit applications.
Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. (2000)

Interleukin 6 (IL-6) is a cytokine that regulates not only immune and inflammatory responses but also the growth of some tumors, including prostate carcinomas. IL-6 signals through Janus kinase, signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinase and is also able to induce androgen receptor (AR)-mediated gene activation in prostate cancer, which is an important process in prostate cancer androgen-independent progression. We now show that IL-6-induced AR-mediated gene activation requires the activation of STAT3 by IL-6 in LNCaP prostate cancer cells. In particular, STAT3 associates with AR in an androgen-independent but IL-6-dependent manner. Inhibition of STAT3 rather than mitogen-activated protein kinase results in inhibition of AR-mediated gene activation in response to IL-6. These findings not only identify STAT3 as an important signaling molecule required for IL-6-signaling to induce AR-mediated gene activation in prostate carcinoma cells but also reveal the importance of activated STAT3 in human tumor development and progression.
Atomic Layer Deposition of Zirconium Titanium Oxide from Titanium Isopropoxide and Zirconium Chloride (2001)

Atomic layer deposition of ZrxTiyOz thin films using titanium isopropoxide and zirconium chloride as precursors in a temperature range of 200−300 °C was studied. Instead of using water or other compounds as a separate oxygen source, titanium isopropoxide served as both an oxygen and a metal source. At 300 °C the growth rate was 1.2 Å/cycle. The permittivity of the ZrxTiyOz films was 45−65, and the leakage current was 10-4 A/cm2 at 0.2 MV/cm. The films were studied by means of spectrophotometry, X-ray diffraction, energy-dispersive X-ray spectroscopy, ion beam analysis, and electrical measurements.
A Long-Wavelength Fluorescent Chemodosimeter Selective for Cu(II) Ion in Water (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Long-Wavelength Fluorescent Chemodosimeter Selective for Cu(II) Ion in WaterVirginie Dujols, Francis Ford, and Anthony W. CzarnikView Author Information Department of Chemistry The Ohio State University Columbus, Ohio 43210 Cite this: J. Am. Chem. Soc. 1997, 119, 31, 7386–7387Publication Date (Web):August 6, 1997Publication History Received17 April 1997Published online6 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/ja971221ghttps://doi.org/10.1021/ja971221grapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views10703Altmetric-Citations917LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Fluorescence,Heterocyclic compounds,Ions,Quantum mechanics,Selectivity Get e-Alerts
3-D data acquisition by Rainbow Range Finder (2002)

The Rainbow Range Finder (RRF) has the ability to obtain range information for all image pixels with only one frame TV camera imaging during 1/30 s. The authors propose a novel practical calibration scheme which makes range measurement for all visible pixels possible. An experimental system was developed on that basis, and measurement accuracy was evaluated. A curved surface and a plain surface could be measured with sufficient accuracy. The feasibility of a real-time system with an accuracy of 1% in regard to the measurement region size was demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Global Deterioration Scale for assessment of primary degenerative dementia (1982)

Cognitive decline associated with old age and consistent with the diagnosis of primary degenerative dementia is a unique clinical syndrome with characteristic phenomena and progression. The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages. The authors have used the Global Deterioration Scale successfully for more than 5 years and have validated it against behavioral, neuroanatomic, and neurophysiologic measures in patients with primary degenerative dementia.
FEM simulation of 3D deformable solids (2012)

A practical guide to finite-element-method (FEM) simulation of 3D deformable solids reviews essential offline FEM simulation techniques: complex nonlinear materials, invertible treatment of elasticity, and model-reduction techniques for real-time simulation.
Tafazzin Knockdown in Mice Leads to a Developmental Cardiomyopathy With Early Diastolic Dysfunction Preceding Myocardial Noncompaction (2012)

In this murine model, tafazzin deficiency leads to a unique developmental cardiomyopathy characterized by ventricular myocardial hypertrabeculation-noncompaction and early lethality. A central role of cardiolipin and mitochondrial functioning is strongly implicated in cardiomyocyte differentiation and myocardial patterning required for heart development. (J Am Heart Assoc. 2012;1:jah3-e000455 doi: 10.1161/JAHA.111.000455.).
Pituitary follicular cells produce basic fibroblast growth factor. (1987)

Cultured monolayers of bovine pituitary follicular cells, which transport ions, contain high amounts of mitogenic activity for endothelial cells which, on the basis of gene expression analysis, heparin-Sepharose elution profile, bioassay, immunoblotting, radioimmunoassay, and radioreceptor assay, has been identified as basic fibroblast growth factor (bFGF). These data indicate that follicular cells may be a major source of bFGF in the pituitary gland. Considering that bFGF has been proposed to play a role in paracrine regulation of pituitary hormone secretion, the data also suggest that these cells may exert important local regulatory functions.
Optimization of silver nanowire networks for polymer light emitting diode electrodes (2013)

Silver nanowire (Ag NW) networks are promising candidates for replacement of indium tin oxide (ITO). However, transparent conductors based on Ag NW networks often suffer from 'haziness' resulting from surface roughness. Thus, in addition to achieving suitable transparency and conductivity, surface roughness must be minimized if realistic implementation of Ag NW networks as transparent conductors is to be realized. In this work, we have reduced the surface roughness of Ag NW networks to below 5 nm as compared to 54 nm for as-deposited Ag NWs through optimization of the low temperature annealing treatment and planarization by poly(3,4 ethylenedioxythiophene)-poly(styrenesulfanate). Using this method, we have been able to produce Ag NW networks with transmittances and sheet resistances of 87% and 11Ω/sq, respectively. These are some of the best values reported for non-oxide-based transparent conductors. Incorporation of these smooth Ag networks into polymer light emitting diodes fabricated in our laboratory yields device characteristics that are comparable to or better than those with commercially available ITO.
Assessment of the Current Intensity for Preventing Ice Accretion on Overhead Conductors (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper concerns the determination of the electric current requirements for an anti-icing technique based on the Joule effect. The minimum current intensity needed for preventing ice accretion depends on several conductor parameters, including external diameter, electrical resistance, as well as surface geometry (number and diameter of external strands). It depends also on meteorological conditions, such as air temperature, wind velocity, and liquid water content. The study comprises the elaboration of a mathematical model and the laboratory experiments for validation. This research work is mainly concerned with power-line conductor and atmospheric parameters. Therefore, four different types of single A1/S1 power-line conductors are investigated. The analytical model was validated with the experiments performed in the wind tunnel of CIGELE Icing Research Pavilion at the University of Quebec, Chicoutimi. In order to complete the mathematical model, it is necessary to assess the overall heat transfer coefficient (HTC) for stranded conductors. The HTC measurements are presented for conductors with different surface geometries. </para>
Lysophosphatidylcholine-induced Surface Redistribution Regulates Signaling of the Murine G Protein-coupled Receptor G2A (2005)

Intracellular trafficking and spatial dynamics of membrane receptors critically regulate receptor function. Using microscopic and subcellular fractionation analysis, we studied the localization of the murine G protein-coupled receptor G2A (muG2A). Evaluating green fluorescent protein-tagged, exogenously expressed as well as the endogenous muG2A, we observed that this receptor was spontaneously internalized and accumulated in endosomal compartments, whereas its surface expression was enhanced and stabilized by lysophosphatidylcholine (LPC) treatment. Monensin, a general inhibitor of recycling pathways, blocked LPC-regulated surface localization of muG2A as well as muG2A-dependent extracellular signal-regulated kinase (ERK) activation and cell migration induced by LPC treatment. Mutation of the conserved DRY motif (R-->A) enhanced the surface expression of muG2A, resulting in its resistance to monensin inhibition of ERK activation. Our data suggest that intracellular sequestration and surface expression regulated by LPC, rather than direct agonistic activity control the signaling responses of murine G2A toward LPC.