gebhart/patrepeval huggingface dataset:
Third-Party Authentication in the Institutional File System (1992)

The use of intermediate translators in the Institutional File System presents the problem of authenticating the translator to the file server where the client&amp;apos;s private key is not known to the translator. We have implemented a modification to the Kerberos authentication exchange that allows our translators to securely acquire the rights necessary for them to access files and other services on behalf of their clients. February 2, Center for Information Technology Integration 1 Third-Party Authentication in the Institutional File System Bill Doster Bill.Doster@umich.edu Jim Rees Jim.Rees@umich.edu Introduction The Institutional File System (IFS) [1] is a large, heterogeneous distributed file system developed at the Center for Information Technology Integration (CITI) and based on AFS [2]. Authentication in AFS between clients and servers is provided by the Kerberos Authentication System [3]. Eventually we expect to support tens of thousands of file system clients. While many of these c...
PC Administration Tools: Using Linux to Manage Personal Computers (1996)

Personal computers in a networked environment can provide users with access to a broad set of distributed resources. Unfortunately, the management overhead of maintaining PC clients can become overwhelming, especially with a large installed base. Popular PC operating systems do not provide system administrators with a set of efficient and flexible management tools that can take advantage of a networked environment. UNIX system administrators are accustomed to having such tools at their disposal to handle common administration tasks, such as software upgrades, initial machine installation, networked file transfer, and remote backup.

This paper describes the PC Administration (PCADM) tools developed to provide PCs with a UNIX environment and robust tool set for client administration purposes, without installing supporting software on individual clients. Linux, custom scripts and libraries, MD5 signatures, and freely available software including Perl [Schwartz], Bash, and SAMBA are used to accomplish this task - all made accessible from a single floppy disk.
Bence Jones proteins and light chains of immunoglobulins. Preferential association of the V lambda VI subgroup of human light chains with amyloidosis AL (lambda). (1982)

An antiserum prepared against a lambda-Bence Jones protein from a patient (SUT) who had multiple myeloma and amyloidosis had specificity for lambda-light chains of the chemically defined variable (V) region lambda-chain subgroup lambda VI. Sequence analyses of protein SUT and of five other lambda-light chains recognized immunologically as of the V lambda VI subgroup revealed that all six proteins had the N-terminal sequence characteristic for prototype lambda VI proteins. The isotypic nature of the V lambda VI subgroup was demonstrated immunochemically: lambda VI molecules were detected among light chains isolated from the IgG proteins of each of 12 normal individuals and lambda VI antigenic determinants were also detectable on the intact IgG proteins. The frequency of lambda VI molecules among lambda-type light chains is estimated to be approximately 5% based on the finding that 5 of 91 lambda Bence Jones proteins were of the V lambda VI subgroup. Proteins of the V lambda VI subgroup, in contrast to those of the other five chemically-classified lambda chain subgroup, appear to be preferentially associated with the amyloid process as evidenced by the fact that all six lambda VI proteins were obtained from patients with amyloidosis AL and, in addition, 5 of 42 lambda-type monoclonal immunoglobulins from patients with primary or myeloma-associated amyloidosis were classified by immunodiffusion analyses as having lambda VI-type light chains.
A review of the coelotine genus Eurocoelotes (Araneae: Amaurobiidae) (2010)

The genus Eurocoelotes, established in 2002 with fourteen species from Europe, including two new species, E. halanensis sp. nov. (♀ only) from Mali Halan, Croatia and E. paramicrolepidus sp. nov. (♂ only) from Peloponnisos, Greece, is reviewed. Each species is described with a focus on the male palp and the female epigynum. A key to species is provided. Except for E. deltshevi (Dinitrov 1996) and E. drenskii (Deltshev 1990), specimens of which were not available, we have provided illustrations for the male palp and the female epigynum of all species. In general, the male Eurocoelotes has a short cymbial furrow, a broad conductor dorsal apophysis, a spoon-shaped median apophysis, and a prolaterally originating embolus, but lacks a patellar apophysis. The female Eurocoelotes usually has laterally arising epigynal teeth, a large, anteriorly situated atrium, large copulatory ducts, and short, slightly longitudinally extending spermathecae. Exceptions include: E. falciger (Kulczyński 1897), which has a long cymbial furrow and a proximally originating embolus, E. anoplus (Kulczyński 1897) and E. gasperinii (Simon 1891), which have proximally originating emboli, E. brevispinus (Deltshev & Dimitrov 1996), which has a distinct patellar apophysis, E. microlepidus (de Blauwe 1973) and E. paramicrolepidus, which have a tiny patellar apophysis, and E. xinpingwangi Deltshev 2009, which has no epigynal teeth.
Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death. (1994)

Our previous work in the adult porcine model shows that brain death results in a rapid decline in left ventricular systolic function as measured by the preload recruitable stroke work method to 8% of the baseline slope within 6 hours; this process is accompanied by functional uncoupling of the beta-adrenergic receptor at the level of the adenylyl cyclase moiety within 1 hour. In contrast, the pediatric porcine myocardium displays no change in left ventricular systolic function from baseline within 6 hours of brain death. This work investigates whether the beta-adrenergic receptor/adenylyl cyclase pathway remains intact after induction of brain death in the pediatric porcine model. Thirteen 1-month-old swine (7 to 10 kg) were anesthetized and underwent median sternotomy, and baseline transmural left ventricular biopsy specimens were obtained before ligation of head vessels to induce brain death in six piglets, with the remaining seven serving as controls. Baseline left ventricular biopsy specimens were obtained just before and 1 and 3 hours after brain death or at matched time points without brain death in the control group. Myocardial tissue was then analyzed for beta-adrenergic receptor density with the use of saturation [125I]-iodocyanopindolol binding in the absence and presence of propranolol 1 mumol/L. Coupling of the beta-adrenergic receptor to its signal transduction system (stimulation of adenylyl cyclase) was tested at three levels: beta-adrenergic receptor (isoproterenol 100 mumol/L), stimulatory G protein Gs (sodium fluoride 10 mmol/L), and the adenylyl cyclase moiety itself (forskolin 100 mumol/L).(ABSTRACT TRUNCATED AT 250 WORDS)
9-Nitrocamptothecin liposome aerosol treatment of melanoma and osteosarcoma lung metastases in mice. (2000)

The response rates of relapsed osteosarcoma and melanoma pulmonary metastases to traditional i.v. chemotherapeutic regimens have been disappointing. Direct drug delivery of chemotherapy to the lungs could increase the drug concentration in the tumor area and may offer a new therapeutic approach for these patients. Previous studies demonstrated that drugs delivered to the respiratory tract in liposomal formulation resulted in high pulmonary drug concentration, reduced systemic toxicity, and reduced dosage requirements compared with parenteral and oral administration. To determine whether this approach has utility against pulmonary metastases, the efficacy of aerosol therapy with liposome-encapsulated 9-nitrocamptothecin (L-9NC) was determined using two different experimental lung metastasis models. C57BL/6 mice were treated the day after the i.v. injection of B16 melanoma cells with aerosol L-9NC for 1 h (153 microg 9-nitrocamptothecin/kg) for 5 days per week for up to 3 weeks. Aerosol L-9NC treatment resulted in a reduction in lung weights (P = 0.005) and number of tumor foci (P < 0.001). Visible tumor nodules were fewer and smaller in the 9-nitrocamptothecin-treated group than in untreated control mice (P < 0.001). Using a newly developed human osteosarcoma experimental metastasis model in nude mice, we demonstrated that aerosol L-9NC was also effective against established lung metastases. Aerosol therapy initiated on the ninth week after i.v. tumor injection and continued for 8 or 10 weeks produced highly significant reductions in the number of animals with both visible and microscopic disease (P < 0.02), the total number of tumor foci in the lungs (P < 0.005), and the size of the individual tumor nodules (P < 0.02). These data suggest that L-9NC aerosol therapy may offer significant advantage over existing methods in the treatment of melanoma and osteosarcoma pulmonary metastases.
Differential Regulation of Oxidative and Osmotic Stress Induced Syk Activation by both Autophosphorylation and SH2 Domains (1998)

Syk, a nonreceptor protein-tyrosine kinase, is activated by both oxidative and osmotic stress and plays different roles in the transduction of stress signals. In this study, the regulation of oxidative and osmotic stress induced Syk activation was investigated utilizing Syk-negative DT40 cells, expressing various Syk mutants. Phosphorylation of Y518Y519 was demonstrated to be required for both oxidative and osmotic stress induced Syk activation. Syk activation by these two types of stress stimuli was a combination of both autophosphorylation and the activities of additional tyrosine kinases. Oxidative stress induced Syk tyrosine phosphorylation was almost completely attributed to autophosphorylation, whereas other tyrosine kinases were largely responsible for osmotic stress induced Syk tyrosine phosphorylation. Moreover, the Src homology 2 (SH2) domains of Syk differentially regulated Syk activation. Both mSH2(N) Syk and mSH2(C) Syk, in which the phosphotyrosine-dependent binding motif within the SH2 domains contained point mutations, showed a significantly higher activity than that observed in wild-type Syk, following osmotic stress treatment. In comparison, in response to oxidative stress, only mSH2(N) Syk demonstrated a stronger activation than wild-type Syk. Therefore, differential activation and regulation of Syk may give an insight into the distinctive functions of Syk in oxidative and osmotic stress signaling.
A practical guide to microfluidic perfusion culture of adherent mammalian cells (2007)

Culturing cells at microscales allows control over microenvironmental cues, such as cell-cell and cell-matrix interactions; the potential to scale experiments; the use of small culture volumes; and the ability to integrate with microsystem technologies for on-chip experimentation. Microfluidic perfusion culture in particular allows controlled delivery and removal of soluble biochemical molecules in the extracellular microenvironment, and controlled application of mechanical forces exerted via fluid flow. There are many challenges to designing and operating a robust microfluidic perfusion culture system for routine culture of adherent mammalian cells. The current literature on microfluidic perfusion culture treats microfluidic design, device fabrication, cell culture, and micro-assays independently. Here we systematically present and discuss important design considerations in the context of the entire microfluidic perfusion culture system. These design considerations include the choice of materials, culture configurations, microfluidic network fabrication and micro-assays. We also present technical issues such as sterilization; seeding cells in both 2D and 3D configurations; and operating the system under optimized mass transport and shear stress conditions, free of air-bubbles. The integrative and systematic treatment of the microfluidic system design and fabrication, cell culture, and micro-assays provides novices with an effective starting point to build and operate a robust microfludic perfusion culture system for various applications.
The Environmental Texture of Seafood Distribution in Japan (1993)

A startegic management approach is used to assess the nature of business environments affecting seafood distribution in Japan. Notions of environment ‘textures’ described in an influential paper by Emery and Trist are used to determine the current degree of environmental turbulence and the implications for export strategies. The environment as a whole is found to exhibit ‘medium turbulence’, and the sectors of importing, wholesaling, and food retailing/service are ‘medium’ to ‘high’ turbulence'. To cope with such environments, firms must undertake extensive real‐time market research (e.g. using POS information accessed via computer); develop flexible structures and operating systems (to become more responsive); and focus on improving communication and meeting the changing customer needs.
Architecting phase change memory as a scalable dram alternative (2009)

Memory scaling is in jeopardy as charge storage and sensing mechanisms become less reliable for prevalent memory technologies, such as DRAM. In contrast, phase change memory (PCM) storage relies on scalable current and thermal mechanisms. To exploit PCM's scalability as a DRAM alternative, PCM must be architected to address relatively long latencies, high energy writes, and finite endurance.We propose, crafted from a fundamental understanding of PCM technology parameters, area-neutral architectural enhancements that address these limitations and make PCM competitive with DRAM. A baseline PCM system is 1.6x slower and requires 2.2x more energy than a DRAM system. Buffer reorganizations reduce this delay and energy gap to 1.2x and 1.0x, using narrow rows to mitigate write energy and multiple rows to improve locality and write coalescing. Partial writes enhance memory endurance, providing 5.6 years of lifetime. Process scaling will further reduce PCM energy costs and improve endurance.
NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population (2004)

Jamain [2003: Nat Genet 34:27-29] recently reported mutations in two neuroligin genes in sib-pairs affected with autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 96 individuals affected with autism. We found no mutations in these X-linked genes. These results indicate that mutations in NLGN3 and NLGN4 genes are responsible for at most a small fraction of autism cases and additional screenings in other autistic populations are needed to better determine the frequency with which mutations in NLGN3 and NLGN4 occur in autism.
A bispecific nanobody to provide full protection against lethal scorpion envenoming (2010)

Envenoming following scorpion sting is a common emergency in many parts of the world. Our aim was to ameliorate the current 100-kDa horse plasma antivenom serum (PAS)-derived Fab'(2) to more quickly reach the highly diffusible scorpion toxins (7 kDa). We immunized dromedaries with toxins from Androctonus australis hector (Aah) scorpions and cloned the single-domain antibody fragments or nanobodies (15 kDa) from their B cells. Nanobodies against AahI' toxin (with AahII the most toxic compound of the venom) were retrieved from the libraries, and their AahI'-toxin neutralization was monitored in mice. Remarkably, the NbAahI'F12 fully protected mice against 100 LD(50) of AahI' administered intracerebroventricularly. Moreover, where PAS failed completely to neutralize 2 LD(50) of crude venom injected subcutaneously, the designed bispecific NbF12-10 against AahI'/AahII toxins succeeded in neutralizing 5 LD(50). Finally, in a challenge assay in which mice were subcutaneously injected with a lethal dose of scorpion venom, the subsequent intravenous injection of 85 microg of NbF12-10 protected all mice, even if the whole procedure was repeated 3 times. Furthermore, the NbF12-10 remained fully protective when mice with severe signs of envenoming were treated a few minutes before the untreated mice died.
Chronic inflammation in the pathogenesis of benign prostatic hyperplasia (2009)

Summary Benign prostatic hyperplasia (BPH) is a common disorder affecting 50–80% of the aged male population. Androgens and age have been traditionally considered the main determinants of prostate enlargement, but in the last years a potentially important role of chronic inflammation in BPH pathogenesis has emerged. Bacterial and non‐infectious chronic prostatitis could represent inciting factors leading to tissue hyperproliferation, possibly via the recently demonstrated antigen‐presenting capacity of prostatic stromal cells, enabling them to induce and sustain intraglandular immune responses. The prostate growth‐promoting chemokine IL‐8 could represent a direct link between chronic prostate inflammation and autocrine/paracrine stromal cell proliferation, in agreement with its marked secretion induced in BPH stromal cells by a combination of Th1 and Th17 cell‐derived inflammatory cytokines. BPH stromal cells express the vitamin D receptor (VDR), which is up‐regulated by exposure to inflammatory stimuli. The non‐hypercalcaemic VDR agonist elocalcitol, shown to arrest BPH development by decreasing the intra‐prostatic androgen signalling without directly interfering with systemic androgen action, exerts immunoregulatory and anti‐inflammatory properties in different prostatic pathology characterized by growth and inflammation. The mechanism of action of VDR agonists supports an important role of chronic inflammation in BPH pathogenesis and strengthens the concept of these agents as a therapeutic option for pharmacological treatment of BPH.
Liver Transplantation After Organ Preservation With Normothermic Extracorporeal Perfusion (2001)

The technique of NELP holds the potential to keep a mammalian liver outside the body completely functional, possibly for more than 4 hours. NELP can be used for liver preservation before transplantation or for the use of organs from non-heart-beating donors.
THE LYMPHATIC VASCULATURE: Recent Progress and Paradigms (2005)

The field of lymphatic research has been recently invigorated by the identification of genes and mechanisms that control various aspects of lymphatic development. We are beginning to understand how, starting from a subgroup of embryonic venous endothelial cells, the whole lymphatic system forms in a stepwise manner. The generation of genetically engineered mice with defects in different steps of the lymphangiogenic program has provided models that are increasing our understanding of the lymphatic system in health and disease. This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis.
Viscosity B-Coefficients of Ions in Solution (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTViscosity B-Coefficients of Ions in SolutionH. Donald B. Jenkins and Yizhak MarcusCite this: Chem. Rev. 1995, 95, 8, 2695–2724Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/cr00040a004https://doi.org/10.1021/cr00040a004research-articleACS PublicationsRequest reuse permissionsArticle Views3582Altmetric-Citations596LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Integrative Analysis of Genomic Aberrations Associated with Prostate Cancer Progression (2007)

Integrative analysis of genomic aberrations in the context of trancriptomic alterations will lead to a more comprehensive perspective on prostate cancer progression. Genome-wide copy number changes were monitored using array comparative genomic hybridization of laser-capture microdissected prostate cancer samples spanning stages of prostate cancer progression, including precursor lesions, clinically localized disease, and metastatic disease. A total of 62 specific cell populations from 38 patients were profiled. Minimal common regions (MCR) of alterations were defined for each sample type, and metastatic samples displayed the most number of alterations. Clinically localized prostate cancer samples with high Gleason grade resembled metastatic samples with respect to the size of altered regions and number of affected genes. A total of 9 out of 13 MCRs in the putative precursor lesion, high-grade prostatic intraepithelial neoplasia (PIN), showed an overlap with prostate cancer cases (amplifications in 3q29, 5q31.3-q32, 6q27, and 8q24.3 and deletions in 6q22.31, 16p12.2, 17q21.2, and 17q21.31), whereas postatrophic hyperplasia (PAH) did not exhibit this overlap. Interestingly, prostate cancers that do not overexpress ETS family members (i.e., gene fusion-negative prostate cancers) harbor differential aberrations in 1q23, 6q16, 6q21, 10q23, and 10q24. Integrative analysis with matched mRNA profiles identified genetic alterations in several proposed candidate genes implicated in prostate cancer progression.
Prechirped duobinary modulation (1998)

The proposed modulation scheme enables us to combine the advantages of the duobinary modulation, i.e., reduced transmission bandwidth compared to traditional intensity modulation, together with the advantages of prechirped modulation. Below, a theoretical investigation is presented where four different methods of modulating a double electrode Mach-Zehnder modulator is compared. It will be shown that the proposed prechirped duobinary modulation scheme will have the best performance in terms of power penalty.
Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells (2010)

Paclitaxel has emerged as a front line treatment for aggressive malignancies of the breast, lung, and ovary. Successful therapy of cancer is frequently undermined by the development of paclitaxel resistance. There is a growing need to find other therapeutic targets to facilitate treatment of drug-resistant cancers. Using a proteomics approach, elevated levels of Prohibitin1 (PHB1) and GSTpi were found associated with paclitaxel resistance in discrete subcellular fractions of two drug-resistant sublines relative to their sensitive sublines. Immunofluorescence staining and fractionation studies revealed increased levels of PHB1 on the surface of resistant cell lines. Transiently silencing either PHB1 or GSTpi gene expression using siRNA in the paclitaxel-resistant cancer cell sublines partially sensitized these cells toward paclitaxel. Intriguingly, silencing PHB1 but not GSTpi resulted in activation of the intrinsic apoptosis pathway in response to paclitaxel. Similarly, stably silencing either PHB1 or GSTpi significantly improved paclitaxel sensitivity in A549TR cells both in vitro and in vivo. Our results indicate that PHB1 is a mediator of paclitaxel resistance and that this resistance may depend on the cellular localization of the protein. We suggest PHB1 as a potential target for therapeutic strategies for the treatment of drug-resistant tumors.