gebhart/patrepeval huggingface dataset:
Electronic-band parameters in strainedSi1−xGexalloys onSi1−yGeysubstrates (1993)

A systematic theoretical study of the electronic properties of pseudomorphic (100)-strained ${\mathrm{Si}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Ge}}_{\mathit{x}}$ alloys grown on unstrained ${\mathrm{Si}}_{1\mathrm{\ensuremath{-}}\mathit{y}}$${\mathrm{Ge}}_{\mathit{y}}$ substrates is presented. Based on nonlocal empirical pseudopotential calculations with spin-orbit interactions, realistic estimates of the conduction- and valence-band-edge energies, higher-energy-band minima, effective masses, deformation potentials, and heterostructure band offsets for the whole range of alloy compositions x and y and strain are presented. The theory predicts that the band edges of weakly stressed Ge fall within the wider gap of the ${\mathrm{Si}}_{1\mathrm{\ensuremath{-}}\mathit{y}}$${\mathrm{Ge}}_{\mathit{y}}$ substrate for 0.7y1 (type-I alignment), in contrast to any Si-rich combination of active layer and substrate.
Stimulation of early embryonic development in the sheep by co-culture with oviduct epithelial cells (1987)

To examine the effects of somatic cell support on the cleavage and viability of fertilized sheep eggs, 434 pronucleate eggs were co-cultured for 3 or 6 days on oviduct cells or fibroblasts and 77 eggs were cultured in medium alone. During the first 3 days in culture 95% of the single-celled eggs cleaved regularly to non-compacted morulae on either of the feeder-layers but only 13% underwent similar regular cleavage in medium alone. Despite the identical cleavage rates in the co-culture groups, only 33% of embryos grown on fibroblasts as compared with 80% of embryos grown on oviduct cells were fully viable as judged by their ability to develop normally after transfer to recipient animals. The viability of embryos in the oviduct group was equal to that obtained after the direct transfer of morulae from donor to recipient sheep. After 6 days in culture 42% of embryos co-cultured with oviduct cells developed into expanded blastocysts as compared with only 4.5% cultured on fibroblasts. In both co-culture groups virtually all the remaining embryos blocked during the 4th cleavage. When transferred, 30% of blastocysts grown from the pronucleate stage on oviduct cells were viable. We conclude that: (1) during the first 3 days after fertilization cleavage will progress at a normal rate on different feeder-layers but oviduct cells appear to be required for the acquisition of full embryonic viability.(ABSTRACT TRUNCATED AT 250 WORDS)
Identification of a Fourth Half ABC Transporter in the Human Peroxisomal Membrane (1997)

Three half ATP-binding cassette transporters (ALDP, ALDR, PMP70) are known to be present in the human peroxisome membrane. Mutations in the gene encoding ALDP cause X-linked adrenoleukodystrophy; the role of ALDR and PMP70 in human disease is unclear. We report the cloning and characterization of a fourth human gene encoding a peroxisomal half ABC transporter. The gene, designated P70R, maps to chromosome 14q24, encodes a 73 kDa transporter most similar to PMP70, and is expressed in all human tissues examined. Because half ABC transporters heterodimerize to form functional transporters, the identification of a fourth member of this family in the peroxisome membrane has implications for our understanding of mammalian peroxisomes and the genetic disorders of peroxisomal function.
Genetic and Biochemical Analysis of the Ability of Saccharomyces cerevisiae to Decarboxylate Cinnamic Acids (1982)

Decarboxylation of ferulate to 4-vinylguaiacol is associated with the production of a phenolic off-flavour in beer. The ability (Pof+) of non-brewing strains of Saccharomyces cerevisiae to carry out this reaction has been assigned, by tetrad analysis, to a single nuclear gene. This gene (POF1) is dominant in heterozygous diploids and segregates independently from MATa/MATα, lys2 and DEX1. Therefore, elimination of the Pof+ phenotype from strains intended for brewing is feasible by either mutation or genetic segregation. Since ferulate was decarboxylated by cell-free supernatants derived from Pof+ strains, but not by similar fractions from Pof- strains, POF1 encodes production of a cellular decarboxylase. Strains carrying POF1 also decarboxylated coumarate and cinnamate in vivo, but with caffeate, 4-hydroxybenzoate, 4-hydroxyphenylacetate, styrylacetate, mandelate or phenylpropionate as substrates, the corresponding decarboxylation products were not detected. POF1 may confer resistance to inhibitory effects of naturally occurring cinnamates on yeast growth.
In vivo primed mouse T cells selectively express T cell-specific serine proteinase-1 and the proteinase-like molecules granzyme B and C (1991)

Previous studies have shown that mouse CD8+ T lymphocyte clones (TLC) produce T cell-specific serine proteinase-1 (MTSP-1) as well as a family of six homologous molecules, termed granzymes B - G, which are structurally related to serine proteinases. Of these proteins, only MTSP-1 has been studied in detail. It has been shown to occur in the majority of CD8+ and a fraction of CD4+ T effector cells in vivo and in vitro and has demonstrable enzyme activity in these cells. The presence of the other serine proteinase-like molecules in T cells is less well defined. We have now analyzed the expression of mRNA species specific for granzymes B - G in activated T cell populations using the sensitive polymerase chain reaction which allows the detection of mRNA species from as little as 2 pg of total cytoplasmic RNA. We demonstrate that MTSP-1 and all six serine proteinase-like transcripts are expressed in a panel of four CD8+ and six CD4+ long-term-cultured TLC, though at greatly differing concentrations. In contrast, in vivo primed T cells of both phenotypes, CD4+ and CD8+, and in vitro activated T cells derived from short-term cultures only express mRNA species specific for MTSP-1 and CCP1 and little of those for CCP2, but no transcripts for granzymes D - G. These findings argue against the participation of granzymes D - G in T cell-mediated functions in vivo.
A novel approach for proper name transliteration verification (2010)

Proper name transliteration, the pronunciation based translation of a proper name, is important to many multilingual natural language processing task, such as Statistical Machine Translation (SMT) and Cross Lingual Information Retrieval (CLIR). This task is extremely challenging due to the pronunciation difference between the source and target language. A given proper name can lead to many different transliterations. In the past, research efforts had demonstrated a 30-50% error using top-1 reference for transliteration. This error leads to performance degradation for many applications. In this paper, a novel approach to verify a given proper name transliteration pair using a discrete variant Hidden Markov Model (HMM) alignment is proposed. The state emission probabilities are derived from SMT phrase tables. The proposed method yields an Equal Error Rate (EER) of 3.73% on a 300 matched and 1000 unmatched name pairs test set. By comparison, the commonly used SMT framework yields 6.5% EER under the best configuration. The widely used edit distance approach has an EER of 22%. Our new method achieves high accuracy and low complexity, and provides an alternative for name transliteration in CLIR and other cross lingual natural language applications such as word alignment and machine translation.
Tumor visualization with a radioiodinated phospholipid ether. (1990)

The known ability of phospholipid ethers to accumulate in certain tumors prompted the synthesis and evaluation of a radioiodinated phospholipid ether analog as a potential tumor imaging agent. Tissue distribution studies with [125I]-rac-1-0-[12-(m-iodophenyl)dodecyl-2-0-methylglycero-3- phosphocholine in rats bearing the Walker 256 carcinosarcoma showed the tumor to contain the highest concentration of radioactivity at 24 hr (15% of the dose) and a tumor-to-blood ratio of 13. Scintigraphic images taken at 24 hr compared favorably with those obtained with (67Ga)-citrate. In contrast with the latter, however, the phospholipid ether showed little propensity to accumulate in an inflammatory lesion in the rat. Tumor visualization was also accomplished in a rabbit bearing the V x 2 adenocarcinoma. We conclude that phospholipid ethers may represent a new class of carrier molecules for the transport of radionuclides to tumors.
A transparent, all-optical, metropolitan network experiment in a field environment: the "PROMETEO" self-healing ring (1997)

In this paper, we present an optical network demonstrator realizing a wavelength division multiplexing (WDM) metropolitan self-healing ring. The network integrate three optical add-drop multiplexer (OADM) nodes, designed by two manufacturing companies adopting different architectures and technological solution. It is so demonstrated that transversal compatibility among optical network entities produced by different companies is possible at the state of the art of the technology. A complete transmission performance characterization of the network has been carried out demonstrating that, in nominal operating conditions and on the most critical path, the error probability is lower that 10/sup -14/. The reconfiguration times in case of failure has been measured too, demonstrating that this network architecture provide fast self-healing mechanism, in line with the requirements of ITU-T recommendations for very high capacity networks.
STUDIES ON BACTERIEMIA (1956)

During the course of studies on the characteristics of experimental bacteriemia, staphylococci were swiftly cleared from the blood stream of rabbits during the initial 10 to 15 minutes following intravenous injection of microorganisms. A subsequent abrupt decline in the rate of clearance ensued, resulting in a low grade bacteriemia which was demonstrable for many hours. The experiments reported have indicated that this strain of staphylococcus is rapidly phagocyted within the vascular system of rabbits, and that viable staphylococci circulate within the cytoplasm of polymorphonuclear leukocytes. The removal mechanisms contained within the liver and spleen appear to preferentially trap circulating extracellular staphylococci. When most of the circulating staphylococci are contained within leukocytes, splanchnic removal declines or virtually ceases. These observations suggest that viable, intracellular microorganisms are responsible for the persistence of staphylococcal bacteriemia in rabbits following the phase of rapid removal from the blood stream.
A simple map-based localization strategy using range measurements (2005)

In this paper we present a map-based approach to localization. We consider indoor navigation in known environments based on the idea of a "vector cloud" by observing that any point in a building has an associated vector defining its distance to the key structural components (e.g., walls, ceilings, etc.) of the building in any direction. Given a building blueprint we can derive the "ideal" vector cloud at any point in space. Then, given measurements from sensors on the robot we can compare the measured vector cloud to the possible vector clouds cataloged from the blueprint, thus determining location. We present algorithms for implementing this approach to localization, using the Hamming norm, the 1-norm, and the 2-norm. The effectiveness of the approach is verified by experiments on a 2-D testbed using a mobile robot with a 360° laser range-finder and through simulation analysis of robustness.
Difference between Cognition and Measured Intensity of Bench Press and Squat for Weight Training Beginner and Trained Group, and the Development of 1-RM Prediction Model Based on Cognition Intensity (2013)

상명대학교초록 운동학 학술지, 2013, 15(4): 1-12.웨이트 트레이닝 남성 초보자와 중상급자의 Bench press와 Squat 인지강도와 실측강도의 차 이 및 인지강도를 이용한 1-RM 추정.[서론] 본 연구의 목적은 웨이트 트레이닝 초보자와 중상급자의 벤치 프레스와 스쿼트의 60%, 75% 및 90% 인지강도와 실측강도 차이를 비교하고,
Dysregulated T cell expression of TIM3 in multiple sclerosis (2006)

T cell immunoglobulin- and mucin domain-containing molecule (TIM)3 is a T helper cell (Th)1-associated cell surface molecule that regulates Th1 responses and promotes tolerance in mice, but its expression and function in human T cells is unknown. We generated 104 T cell clones from the cerebrospinal fluid (CSF) of six patients with multiple sclerosis (MS) (n = 72) and four control subjects (n = 32) and assessed their cytokine profiles and expression levels of TIM3 and related molecules. MS CSF clones secreted higher amounts of interferon (IFN)-gamma than did those from control subjects, but paradoxically expressed lower levels of TIM3 and T-bet. Interleukin 12-mediated polarization of CSF clones induced substantially higher amounts of IFN-gamma secretion but lower levels of TIM3 in MS clones relative to control clones, demonstrating that TIM3 expression is dysregulated in MS CSF clones. Reduced levels of TIM3 on MS CSF clones correlated with resistance to tolerance induced by costimulatory blockade. Finally, reduction of TIM3 on ex vivo CD4+ T cells using small interfering (si)RNA enhanced proliferation and IFN-gamma secretion, directly demonstrating that TIM3 expression on human T cells regulates proliferation and IFN-gamma secretion. Failure to up-regulate T cell expression of TIM3 in inflammatory sites may represent a novel, intrinsic defect that contributes to the pathogenesis of MS and other human autoimmune diseases.
Imaging Amyloid-β Deposits In Vivo (2002)

Alzheimer disease (AD) is an illness that can only be diagnosed with certainty with postmortem examination of brain tissue. Tissue samples from afflicted patients show neuronal loss, neurofibrillary tangles (NFTs), and amyloid-beta plaques. An imaging technique that permitted in vivo detection of NFTs or amyloid-beta plaques would be extremely valuable. For example, chronic imaging of senile plaques would provide a readout of the efficacy of experimental therapeutics aimed at removing these neuropathologic lesions. This review discusses the available techniques for imaging amyloid-beta deposits in the intact brain, including magnetic resonance imaging, positron emission tomography, single photon emission computed tomography, and multiphoton microscopy. A variety of agents that target amyloid-beta deposits specifically have been developed using one or several of these imaging modalities. The difficulty in developing these tools lies in the need for the agents to cross the blood-brain barrier while recognizing amyloid-beta with high sensitivity and specificity. This review describes the progress in developing reagents suitable for in vivo imaging of senile plaques.
Enhanced Tumor Protection by Granulocyte-Macrophage Colony-Stimulating Factor Expression at the Site of an Allogeneic Vaccine (1998)

Murine tumor models have demonstrated that whole tumor cell vaccines engineered to secrete certain cytokines in a paracrine fashion elicit systemic immune responses capable of eliminating small amounts of established tumor. In particular, autologous tumors that express the cytokine GM-CSF induce potent systemic immune responses against poorly immunogenic murine tumors. However, phase I clinical trials have demonstrated the technical difficulty of routinely expanding primary autologous human tumor cells to the numbers required for vaccination, making the generalization of autologous vaccines impractical. Dissection of the mechanism by which antitumor immunity is generated has demonstrated that GM-CSF recruits professional antigen-presenting cells that act as intermediates in presenting tumor antigen to and activating effector T cells. Furthermore, the identification of commonly recognized murine and human tumor antigens indicates that many are shared rather than unique. These findings would suggest that allogeneic as well as autologous tumor cells can be used as the vaccinating cells for activating antitumor immunity. A major concern in the application of allogeneic vaccines relates to the potential interference of allogeneic MHC expression at the vaccine site with priming of tumor-specific T cell responses. Here we describe a series of experiments that directly examines the effects of allogeneic MHC molecules on the immune-priming capabilities of a whole cell tumor vaccine engineered to secrete GM-CSF. The results demonstrate that the expression of an allogeneic MHC molecule by a vaccine cell can actually enhance the induction of systemic antitumor immunity. In addition, allogeneic MHC expression has no inhibitory effect on the ability of GM-CSF-transduced vaccines to induce systemic antitumor immunity. These findings support the design of clinical trials for testing this more feasible and generalizable allogeneic whole tumor cell vaccine approach.
Probabilistic data association methods in visual tracking of groups (2004)

Data association is a fundamental problem when tracking large numbers of moving targets. Most commonly employed methods of data association such as the JPDA estimator are combinatorial and therefore do not scale well to large numbers of targets. However, in many cases large numbers of targets form natural groups which can be efficiently tracked. We describe a method for defining groups based on the position and velocity of targets. This definition introduces a natural set of merging and splitting rules that are embedded into a Kalman filtering framework for tracking multiple groups. In cases where groups of different velocities cross, a general methodology for matching measurements to groups is introduced. This algorithm is based on a modified version of the PDA estimator. It is well suited to handle a high number of measurements and extends naturally to additional grouping constraints such as color or shape.
Novel high-isolation FET switches (1996)

This paper describes novel high-isolation monolithic microwave/millimeter-wave integrated circuit (MMIC) field-effect transistor (FET) switches that have higher isolation characteristics than conventional switches without much insertion loss degradation. The newly developed switches consist of series/shunt FETs and T-shaped R-C-R circuit. Each FET switch utilizes the parasitic capacitive component of the FETs in the off-state to produce a band-rejection filter at the operating frequency. The design method of the newly proposed switches and their characteristics are described herein. With this method, the isolation characteristics are improved by more than 15 dB between 5.4 GHz and 6.4 GHz and more than 20 dB between 5.5 GHz and 6.1 GHz over conventional values.
Metabolic design of combination therapy: use of enhanced fluorodeoxyglucose uptake caused by chemotherapy. (1992)

In order to quantify effects of an experimental chemotherapy, MCF7 cells were studied with 14C-fluorodeoxyglucose (FDG) and high-performance liquid chromatography (HPLC). Uptake measurements were performed 1 and 4 hr after the end of a therapy with hexadecylphosphocholine (HPC). A dose- and time-dependent increase of the FDG uptake after therapy was observed, with a maximum at 1 hr after therapy. These data were used to develop a new metabolic design of combination treatment. Several time-dose combinations of HPC and deoxyglucose (DOG) were analyzed for their effects on growth inhibition. The combinations using DOG in the period of pronounced enhancement of FDG uptake (1 hr after HPC treatment) were found to be the most effective with an improvement of up to 520% in growth inhibition. This metabolic design of combination treatment may also be applied in vivo, and PET can be used to optimize the time and dose schedule of the modified treatment protocol.
Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. (1994)

A new tumor-associated antigen, MN, has been identified whose expression correlates with the tumorigenic phenotype of HeLa x fibroblast somatic cell hybrids. Because HeLa is a cell line derived from a cervical carcinoma, we investigated the diagnostic utility of MN expression in cervical neoplasia. It was found that normal cervical tissue does not express the antigen, or does so in occasional focal areas of weakly staining reserve cells. In contrast, significant immunoreactivity (immunoperoxidase staining of paraffin-embedded sections) was observed in cervical intraepithelial neoplasias, adenocarcinoma in situ, and frank carcinomas, both squamous cell and adenocarcinoma. Varying patterns of immunoreactivity were observed and were characterized as diffuse, diffuse/focal, or focal. Greater than 90% of dysplastic or malignant tissues showed immunoreactivity. An interesting observation was that normal cervical tissue associated with cervical intraepithelial neoplasias, or adenocarcinoma in situ showed a staining pattern in the reserve cells and/or normal columnar cells that approximated the level of intensity exhibited by the dysplastic tissue. These results indicate that MN antigen expression has potential utility as a biomarker of cervical neoplasms.
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS (2009)

The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with peptides containing N-terminal phenylalanine, leucine, and tryptophan. These structures, together with a previous structure of ClpS bound to an N-terminal tyrosine, illustrate the molecular basis of recognition of the complete set of primary N-end rule amino acids. In each case, the alpha-amino group and side chain of the N-terminal residue are the major determinants of recognition. The binding pocket for the N-end residue is preformed in the free adaptor, and only small adjustments are needed to accommodate N-end rule residues having substantially different sizes and shapes. M53A ClpS is known to mediate degradation of an expanded repertoire of substrates, including those with N-terminal valine or isoleucine. A structure of Met53A ClpS engaged with an N-end rule tryptophan reveals an essentially wild-type mechanism of recognition, indicating that the Met(53) side chain directly enforces specificity by clashing with and excluding beta-branched side chains. Finally, experimental and structural data suggest mechanisms that make proteins with N-terminal methionine bind very poorly to ClpS, explaining why these high-abundance proteins are not degraded via the N-end rule pathway in the cell.
Endoscopic Anatomy of the Pterygopalatine Fossa and the Transpterygoid Approach: Development of a Surgical Instruction Model (2008)

Our anatomical model provides the means to learn the endoscopic anatomy of the PPF and may be used for the simulation of surgical techniques. An endoscopic endonasal approach provides adequate exposure to all anatomical structures within the PPF. These structures may be used as landmarks to identify and control deeper neurovascular structures. The significance is that an anatomical model facilitates learning the surgical anatomy and the acquisition of surgical skills. A dissection superficial to the vascular structures preserves the neural elements. These nerves and their bony foramina, such as the vidian nerve and V2, are critical anatomical landmarks to identify and control the ICA at the skull base.