gebhart/patrepeval huggingface dataset:
Ronsard the Painter: a Reading of 'Des Peintures contenues dedans un tableau' (1986)

Journal Article RONSARD THE PAINTER: A READING OF ‘DES PEINTURES CONTENUES DEDANS UN TABLEAU’ Get access PHILIP FORD PHILIP FORD CAMBRIDGE Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XL, Issue 1, January 1986, Pages 32–44, https://doi.org/10.1093/fs/XL.1.32 Published: 01 January 1986
Multi-channel pre-beamformed data acquisition system for research on advanced ultrasound imaging methods (2012)

The lack of open access to the pre-beamformed data of an ultrasound scanner has limited the research of novel imaging methods to a few privileged laboratories. To address this need, we have developed a pre-beamformed data acquisition (DAQ) system that can collect data over 128 array elements in parallel from the Ultrasonix series of research-purpose ultrasound scanners. Our DAQ system comprises three system-level blocks: 1) a connector board that interfaces with the array probe and the scanner through a probe connector port; 2) a main board that triggers DAQ and controls data transfer to a computer; and 3) four receiver boards that are each responsible for acquiring 32 channels of digitized raw data and storing them to the on-board memory. This system can acquire pre-beamformed data with 12-bit resolution when using a 40-MHz sampling rate. It houses a 16 GB RAM buffer that is sufficient to store 128 channels of pre-beamformed data for 8000 to 25 000 transmit firings, depending on imaging depth; corresponding to nearly a 2-s period in typical imaging setups. Following the acquisition, the data can be transferred through a USB 2.0 link to a computer for offline processing and analysis. To evaluate the feasibility of using the DAQ system for advanced imaging research, two proof-of-concept investigations have been conducted on beamforming and plane-wave B-flow imaging. Results show that adaptive beamforming algorithms such as the minimum variance approach can generate sharper images of a wire cross-section whose diameter is equal to the imaging wavelength (150 μm in our example). Also, planewave B-flow imaging can provide more consistent visualization of blood speckle movement given the higher temporal resolution of this imaging approach (2500 fps in our example).
A General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the N-Arylation of Nitrogen Heterocycles (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the N-Arylation of Nitrogen HeterocyclesArtis Klapars, Jon C. Antilla, Xiaohua Huang, and Stephen L. BuchwaldView Author Information Department of Chemistry Massachusetts Institute of Technology Cambridge, Massachusetts 02139 Cite this: J. Am. Chem. Soc. 2001, 123, 31, 7727–7729Publication Date (Web):July 12, 2001Publication History Received18 May 2001Revised22 June 2001Published online12 July 2001Published inissue 1 August 2001https://pubs.acs.org/doi/10.1021/ja016226zhttps://doi.org/10.1021/ja016226zrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views26226Altmetric-Citations940LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Catalysts,Heterocyclic compounds,Ligands,Organic reactions Get e-Alerts
Cephalic vein guide wire technique for implantation of permanent pacemakers (1987)

This report describes a modified cephalic vein guide wire technique for the implantation of permanent pacemakers. The procedure was attempted in 11 patients only when pacing leads could not be passed directly into the exposed cephalic vein. Eight bipolar DDD (two leads), two unipolar DDD, and one bipolar VVI (one lead) pulse generators were implanted successfully, with only one relatively minor complication. The cephalic vein guide wire technique provides easy access to the subclavian vein and may allow implantation of most single- and dual-chamber pacemakers with only a cephalic vein cutdown.
Microarray-based detection and genotyping of viral pathogens (2002)

The detection of viral pathogens is of critical importance in biology, medicine, and agriculture. Unfortunately, existing techniques to screen for a broad spectrum of viruses suffer from severe limitations. To facilitate the comprehensive and unbiased analysis of viral prevalence in a given biological setting, we have developed a genomic strategy for highly parallel viral screening. The cornerstone of this approach is a long oligonucleotide (70-mer) DNA microarray capable of simultaneously detecting hundreds of viruses. Using virally infected cell cultures, we were able to efficiently detect and identify many diverse viruses. Related viral serotypes could be distinguished by the unique pattern of hybridization generated by each virus. Furthermore, by selecting microarray elements derived from highly conserved regions within viral families, individual viruses that were not explicitly represented on the microarray were still detected, raising the possibility that this approach could be used for virus discovery. Finally, by using a random PCR amplification strategy in conjunction with the microarray, we were able to detect multiple viruses in human respiratory specimens without the use of sequence-specific or degenerate primers. This method is versatile and greatly expands the spectrum of detectable viruses in a single assay while simultaneously providing the capability to discriminate among viral subtypes.
Kinetics of outer-sphere electron transfers between metal complexes in solutions and polymeric films on modified electrodes (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of outer-sphere electron transfers between metal complexes in solutions and polymeric films on modified electrodesTokuji Ikeda, C. R. Leidner, and Royce W. MurrayCite this: J. Am. Chem. Soc. 1981, 103, 25, 7422–7425Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/ja00415a004https://doi.org/10.1021/ja00415a004research-articleACS PublicationsRequest reuse permissionsArticle Views367Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response (2015)

The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset. Yet, whether additional factors contribute to Mad2's kinetochore localization remains unclear. Here, we report that the conserved AAA+ ATPase TRIP13(PCH-2) localizes to unattached kinetochores and is required for spindle checkpoint activation in Caenorhabditis elegans. pch-2 mutants effectively localized Mad1 to unattached kinetochores, but Mad2 recruitment was significantly reduced. Furthermore, we show that the C. elegans orthologue of the Mad2 inhibitor p31(comet)(CMT-1) interacts with TRIP13(PCH-2) and is required for its localization to unattached kinetochores. These factors also genetically interact, as loss of p31(comet)(CMT-1) partially suppressed the requirement for TRIP13(PCH-2) in Mad2 localization and spindle checkpoint signaling. These data support a model in which the ability of TRIP13(PCH-2) to disassemble a p31(comet)/Mad2 complex, which has been well characterized in the context of checkpoint silencing, is also critical for spindle checkpoint activation.
Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. (1994)

Human cdc25C protein, a specific tyrosine phosphatase that activates the p34cdc2 protein kinase at mitosis, is itself a phosphoprotein that shows increased phosphorylation during the G2-M transition. In vitro, cdc25C protein is substantially phosphorylated by purified p34cdc2-cyclin B protein kinase. Of seven putative phosphorylation sites for p34cdc2 protein kinase present in human cdc25C, five are phosphorylated by p34cdc2 protein kinase in vitro, as assessed by tryptic phosphopeptide mapping and peptide sequencing. These same sites are also phosphorylated in vivo during the G2-M transition in normal mammalian fibroblasts and have been precisely mapped. The cdc25C phosphorylated in vitro by p34cdc2 protein kinase exhibits a 2-3-fold higher activity than the nonphosphorylated cdc25C, as assayed by activation of inactive cdc2 prokinase. Microinjection of purified cdc25C proteins into living fibroblasts reveals that only the phosphorylated form of cdc25 is highly effective in activating G2 cells into premature prophase in a manner similar to microinjection of purified active p34cdc2 protein kinase. Together these data show that multisite phosphorylation of cdc25C by p34cdc2-cyclin B protein kinase occurs at the G2-M transition and is sufficient to induce the autoamplification of cdc2/M-phase promoting factor necessary to drive somatic mammalian cells into mitosis.
Three-dimensional two-photon imaging in polymeric materials (2002)

We report image formation via single and two-photon photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of multiplayer structures. Photoinduced acid generation in the presence of a two-photon fluorescent dye possessing strongly basic functional groups (7-benzothiazolyl-9,9-didecyl-2,2-(N,N- diphenylamino)fluorene underwent protonation upon exposure with UV or near-IR (740 nm fs pulses). Solution studies demonstrate formation of monoprotonated and diprotonated species upon irradiation, each resulting in distinctly different absorption and fluorescence properties. The fluorescence of the original, neutral, fluorophore is quenched upon monoprotonation with a concomitant increase in fluorescence at longer wavelengths due to the monoprotonated form. Hence, two channel two-photon fluorescence imaging provides 'positive' or 'negative' image readout capability. Results of solution and solid polymer thin films experiments are presented.
Oxaliplatin, 5-Fluorouracil, and Leucovorin as Second-Line Treatment for Advanced Pancreatic Cancer (2009)

The median TTP and median OS in this population with poor prognosis suggests some activity, however, only further investigations will be able to establish the clinical value of this combination.
Photodynamic therapy of colorectal cancer using a new light source (1996)

We believe that Versa-Light, is a good light source for PDT. It was effective in both in vitro and animal studies. It can also be safely used for clinical PDT.
P450s: Structural similarities and functional differences (1996)

More than 400 identified P450s are found in prokaryotes and eukaryotes, plante and animals, mitochondria and endoplasmic reticulum that function in areas such as xenobiotic metabolism and steroidogenesis. This superfamily of proteins has proved difficult to study because of the hydrophobic nature of their substrates, their various redox partners, and the membrane association of the eukaryotic proteins. To better understand the structure/function relationship of P450s–what determines substrate specificity and selectivity, what determines redox partner binding, and which regions are involved in membrane binding–we have compared the three crystallized, soluble bacterial P450s (two class I and one class II) and a model of a steroidogenic, eukaryotic P450 (P450arom) in order to define which structural elements form a conserved struc‐tural fold for P450s, what determines specificity of substrate binding and redox partner binding, and which regions are potentially involved in membrane association. We believe there is a conserved structural fold for all P450s that can be used to model those P450s that prove intransigent to structural determination. However, although there appears to be a conserved structural core among P450s, there is sufficient sequence variability that no two P450s are structurally identical.—Graham‐Lorence, S., Peterson, J. A. P450s: Structural similarities and functional differences. FASEB J. 10, 206‐214 (1996)
A generalized composition algorithm for weighted finite-state transducers (2009)

This paper describes a weighted finite-state transducer composition algorithm that generalizes the concept of the composition filter and presents filters that remove useless epsilon paths and push forward labels and weights along epsilon paths. This filtering permits the compostion of large speech recognition contextdependent lexicons and language models much more efficiently in time and space than previously possible. We present experiments on Broadcast News and a spoken query task that demonstrate an∼5% to 10% overhead for dynamic, runtime composition compared to a static, offline composition of the recognition transducer. To our knowledge, this is the first such system with so little overhead.
Recombinant Salmonella vectors in vaccine development. (1994)

A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.
Material removal and precision machining of structural ceramics using Nd:YAG lasers (1995)

Advanced engineering materials, such as ceramics and ceramic composites, are being used increasingly in a number of manufacturing applications. These materials offer very attractive properties including high hardness, high strength and high wear and corrosion resistance. However, because of these very same properties, ceramic materials are difficult to machine. Conventional processes for machining ceramic materials are diamond grinding and ultrasonic machining. Both of these processes are extremely slow and labour intensive and often can not provide the required precision and finish. Lately, lasers have demonstrated to be very effective in machining these hard materials.This paper presents, recent results of our work on the machining of hard ceramics using pulsed Nd:YAG lasers. The effects of laser frequency, focal position, percentage spot overlap, machining speed, and number of layers removed on the depth of the machined groove and surface roughness are discussed. An application of the technology for machining a complex profile is presented.
Gadolinium-DOTA Enhanced MR Imaging of Intracranial Lesions (1989)

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (Gd-DOTA) is the first of a new class of macrocyclic paramagnetic magnetic resonance (MR) contrast agents (gadolinium cryptelates) to be used in clinical practice. Gadolinium-DOTA possesses relaxation properties similar to those of gadolinium diethylene triamine pentaacetic acid (Gd-DTPA). We report our initial clinical experience in 38 patients with intracranial lesions studied with MR before and after injection of Gd-DOTA. Diseases included primary and metastatic brain tumor, cerebral infarct, vascular malformation, meningioma, hemangiopericytoma, schwannoma, and pituitary macroadenoma. Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight. All studies were performed on a superconductive 0.5 T system. As compared to noncontrast T1- and T2-weighted images (WI), Gd-DOTA enhanced T1 WI were useful in defining the anatomy of malignant intraaxial tumors (high-grade glioma, metastasis) and in tumor versus edema differentiation. Low-grade gliomas did not enhance; in these cases the precontrast T2-weighted sequence was found to be more informative. In post-operative patients, Gd-DOTA allowed us to demonstrate residual tumor or tumor recurrence. Extraaxial tumors (meningioma, hemangiopericytoma, neuroma) enhanced markedly, presumably reflecting tumor vascularity. In our experience, the use of Gd-DOTA improves the anatomic definition of cerebral lesions and in some cases increases both MR sensitivity and specificity. We found Gd-DOTA to be a well tolerated and effective paramagnetic contrast agent. Gadolinium-DOTA can be considered as an alternative water-soluble MR contrast agent to Gd-DTPA.
Pretreatment: the key to unlocking low‐cost cellulosic ethanol (2007)

Abstract New transportation fuels are badly needed to reduce our heavy dependence on imported oil and to reduce the release of greenhouse gases that cause global climate change; cellulosic biomass is the only inexpensive resource that can be used for sustainable production of the large volumes of liquid fuels that our transportation sector has historically favored. Furthermore, biological conversion of cellulosic biomass can take advantage of the power of biotechnology to take huge strides toward making biofuels cost competitive. Ethanol production is particularly well suited to marrying this combination of need, resource, and technology. In fact, major advances have already been realized to competitively position cellulosic ethanol with corn ethanol. However, although biotechnology presents important opportunities to achieve very low costs, pretreatment of naturally resistant cellulosic materials is essential if we are to achieve high yields from biological operations; this operation is projected to be the single, most expensive processing step, representing about 20% of the total cost. In addition, pretreatment has pervasive impacts on all other major operations in the overall conversion scheme from choice of feedstock through to size reduction, hydrolysis, and fermentation, and on to product recovery, residue processing, and co‐product potential. A number of different pretreatments involving biological, chemical, physical, and thermal approaches have been investigated over the years, but only those that employ chemicals currently offer the high yields and low costs vital to economic success. Among the most promising are pretreatments using dilute acid, sulfur dioxide, near‐neutral pH control, ammonia expansion, aqueous ammonia, and lime, with significant differences among the sugar‐release patterns. Although projected costs for these options are similar when applied to corn stover, a key need now is to dramatically improve our knowledge of these systems with the goal of advancing pretreatment to substantially reduce costs and to accelerate commercial applications. © 2007 Society of Chemical Industry and John Wiley &amp; Sons, Ltd
Virus sharing, genetic sequencing, and global health security (2014)

This Perspective focuses on the future of the Pandemic Influenza Preparedness (PIP) Framework, which was initially established to promote the fair sharing of public health-related pandemic influenza samples between countries. We examine the changes that need to be made to address the growing likelihood that genetic sequence data might be shared instead of physical virus samples, as well as the need to expand the PIP framework's scope and to improve its fairness.
RazorII: In Situ Error Detection and Correction for PVT and SER Tolerance (2009)

Traditional adaptive methods that compensate for PVT variations need safety margins and cannot respond to rapid environmental changes. In this paper, we present a design (RazorII) which implements a flip-flop with in situ detection and architectural correction of variation-induced delay errors. Error detection is based on flagging spurious transitions in the state-holding latch node. The RazorII flip-flop naturally detects logic and register SER. We implement a 64-bit processor in 0.13 mum technology which uses RazorII for SER tolerance and dynamic supply adaptation. RazorII based DVS allows elimination of safety margins and operation at the point of first failure of the processor. We tested and measured 32 different dies and obtained 33% energy savings over traditional DVS using RazorII for supply voltage control. We demonstrate SER tolerance on the RazorII processor through radiation experiments.
Frequent Detection of Merkel Cell Polyomavirus in Human Merkel Cell Carcinomas and Identification of a Unique Deletion in the VP1 Gene (2008)

Merkel cell carcinoma (MCC) is a rare but very aggressive human malignancy of the elderly or immunosuppressed patients. Recently, the clonal integration of a new human polyoma virus, which was termed Merkel cell polyomavirus (MCPyV), has been reported in 8 of 10 MCC patients. In the present study, we studied the formalin-fixed and paraffin-embedded tissue specimens of 39 MCC for the presence of MCPyV by PCR. We applied four different primer sets directed against the large T antigen and the VP1 gene of MCPyV. We were able to detect MCPyV in 77% (n = 30) of MCC as confirmed by sequence analyses of the PCR products. Sequence analyses showed only minor nucleotide changes compared with the previously published MCC sequences. In addition, one patient revealed the amplification of two PCR products using PCR primers directed against the VP1 gene. Sequence analyses confirmed the presence of the expected 351-bp PCR product and in addition a second PCR product of 261 bp containing a unique 90-bp deletion in the VP1 gene, which will lead to a predicted loss of 28 amino acids. The unique 90-bp deletion within the VP1 gene possibly is a result of incomplete viral integration of MCPyV in the MCC. The presence of MCPyV in the majority of MCC tissue specimens in our study strongly underlines a possible role for MCPyV as an etiologic agent in the carcinogenesis of MCC.