gebhart/patrepeval huggingface dataset:
Temperature Dependence of Blue Phosphorescent Cyclometalated Ir(III) Complexes (2009)

The photophysical properties for a series of facial (fac) cyclometalated Ir(III) complexes (fac-Ir(C--N)(3) (C--N = 2-phenylpyridyl (ppy), 2-(4,6-difluorophenyl)pyridyl (F2ppy), 1-phenylpyrazolyl (ppz), 1-(2,4-difluorophenyl)pyrazolyl) (F2ppz), and 1-(2-(9,9'-dimethylfluorenyl))pyrazolyl (flz)), fac-Ir(C--N)(2)(C--N') (C--N = ppz or F2ppz and C--N' = ppy or F2ppy), and fac-Ir(C--C')(3) (C--C' = 1-phenyl-3-methylbenzimidazolyl (pmb)) have been studied in dilute 2-methyltetrahydrofuran (2-MeTHF) solution in a temperature range of 77-378 K. Photoluminescent quantum yields (Phi) for the 10 compounds at room temperature vary between near zero and unity, whereas all emit with high efficiency at low temperature (77 K). The quantum yield for fac-Ir(ppy)(3) (Phi = 0.97) is temperature-independent. For the other complexes, the temperature-dependent data indicates that the luminescent efficiency is primarily determined by thermal deactivation to a nonradiative state. Activation energies and rate constants for both radiative and nonradiative processes were obtained using a Boltzmann analysis of the temperature-dependent luminescent decay data. Activation energies to the nonradiative state are found to range between 1600 and 4800 cm(-1). The pre-exponential factors for deactivation are large for complexes with C--N ligands (10(11)-10(13) s(-1)) and significantly smaller for fac-Ir(pmb)(3) (10(9) s(-1)). The kinetic parameters for decay and results from density functional theory (DFT) calculations of the triplet state are consistent with a nonradiative process involving Ir-N (Ir-C for fac-Ir(pmb)(3)) bond rupture leading to a five-coordinate species that has triplet metal-centered ((3)MC) character. Linear correlations are observed between the activation energy and the energy difference calculated for the emissive and (3)MC states. The energy level for the (3)MC state is estimated to lie between 21,700 and 24,000 cm(-1) for the fac-Ir(C--N)(3) complexes and at 28,000 cm(-1) for fac-Ir(pmb)(3).
Light-Induced Redox Reactions in Nanocrystalline Systems (1995)

A review with 156 refs. on interfacial electron transfer reactions in colloidal semiconductor solns. and thin films and their application for solar light energy conversion and photocatalytic water purifn. Some of the topics discussed include; optical and electronic properties of colloidal semiconductor particles, quantum size effects in the photoluminescence of colloidal semiconductors, light-induced charge sepn., dynamics of interfacial charge transfer processes, properties and prepn. of nanocryst. semiconductor electrodes, energetics and operations of the nanoporous solar cell.
Adult neuroblastoma arising in the superior mediastinum (2011)

Adult onset neuroblastoma arising in the mediastinum, except posterior mediastinum is extremely rare. We report a case of surgically resected neuroblastoma in the superior mediastinum. A 64-year-old male was admitted to a local hospital, after an abnormal shadow had been detected on a chest radiogram on a routine medical checkup. Computed tomography (CT) examination revealed the tumor located in the superior mediastinum. Preoperatively, we suspected malignant lymphoma or lymph node metastasis from an unknown primary site. We resected the mediastinal tumor for both definitive diagnosis and local treatment. The tumor was composed of sheets of small round cells positive for CD56, NSE, chromogranin A, and vimentin, but negative for AE1/3, CK5/6, CK7, CD3, CD20, CD79a, c-kit, S-100, SMA and CD99. N-myc gene amplification was also confirmed and supported diagnosis of neuroblastoma. Chest CT seven months after surgery revealed multiple recurrences in lymph nodes.
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2 (2021)

The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in December 2019, subsequently its abrupt spread across the world has severely affected human life. In a short span of time, COVID-19 has sacked more than one million human lives and marked as a severe global pandemic, which is drastically accountable for the adverse effect directly to the human society, particularly the health care system and the economy. The unavailability of approved and effective drugs or vaccines against COVID-19 further created conditions more adverse and terrifying. To win the war against this pandemic within time there is a desperate need for the most adequate therapeutic treatment, which can be achieved by the collaborative research work among scientists worldwide. In continuation of our efforts to support the scientific community, a review has been presented which discusses the structure and the activity of numerous molecules exhibiting promising SARS-CoV-2 and other CoVs inhibition activities. Furthermore, this review offers an overview of the structure, a plausible mechanism of action of SARS-CoV-2, and crucial structural features substantial to inhibit the primary virus-based and host-based targets involved in SARS-CoV-2 treatment. We anticipate optimistically that this perspective will provide the reader and researcher's better understanding regarding COVID-19 and pave the path in the direction of COVID-19 drug discovery and development paradigm.
Stereoblock Poly(lactic acid): Synthesis via Solid‐State Polycondensation of a Stereocomplexed Mixture of Poly(L‐lactic acid) and Poly(D‐lactic acid) (2005)

Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) and poly(D-lactic acid) with a medium-molecular-weight, respectively. In the next step, these poly(L-lactic acid) and poly(D-lactic acid) are melt-blended in 1:1 ratio to allow formation of their stereocomplex. In the last step, this melt-blend is subjected to solid-state polycondensation at temperature where the dehydrative condensation is allowed to promote chain extension in the amorphous phase with the stereocomplex crystals preserved. Finally, stereoblock poly(lactic acid) having high-molecular-weight is obtained. The stereoblock poly(lactic acid) synthesized by this way shows a higher melting temperature in consequence of the controlled block lengths and the resulting higher-molecular-weight. The product characterization as well as the optimization of the polymerization conditions is described. Changes in M(w) of stereoblock poly(lactic acid) (sb-PLA) as a function of the reaction time.
On the use of combinatorial antibody libraries to clone the "fossil record" of an individual's immune response. (1991)

For about the last century the record of immunological events could only be obtained from serum proteins. We suggest that in the future this will change and the far more detailed nucleic acid record will provide new insights into immunological processes as well as selective access to the complete repertoire.
Copolymerization of 5,6-Dihydrodicyclopentadiene and Ethylene (2008)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTCopolymerization of 5,6-Dihydrodicyclopentadiene and EthyleneSung Jae Na, Chun Ji Wu, Jina Yoo, Bo Eun Kim, and Bun Yeoul Lee*View Author Information Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea* Corresponding author. E-mail: [email protected]Cite this: Macromolecules 2008, 41, 11, 4055–4057Publication Date (Web):May 8, 2008Publication History Received20 February 2008Revised25 March 2008Published online8 May 2008Published inissue 1 June 2008https://pubs.acs.org/doi/10.1021/ma800380rhttps://doi.org/10.1021/ma800380rbrief-reportACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views965Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Copolymerization,Copolymers,Hydrocarbons,Polymers Get e-Alerts
Experimental Mouse Ocular Hypertension: Establishment of the Model (2003)

This method produces persistent IOP elevation in mouse eyes and may be a promising experimental model for the investigation of the biological mechanisms of glaucomatous optic neuropathy.
Nanowire Arrays Defined by Nanoimprint Lithography (2004)

We demonstrate the use of nanoimprint lithography to define arrays of vertical InP nanowires. Each nanowire is individually seeded from a catalyzing gold particle and then grown via vapor−liquid−solid growth in a metal−organic vapor phase epitaxy system. The diameter and position of each nanowire can be controlled to create engineered arrays, demonstrated with a hexagonal photonic crystal pattern. This combination of nanoimprint and self-assembly of nanostructures is attractive for photonics and electronics, as well as in life sciences.
Toward a unified framework for version modeling in engineering databases (1990)

Support for unusual applications such as computer-aided design data has been of increasing interest to database system architects. In this survey, we concentrate on one aspect of such support, namely, version modeling . By this, we mean the concepts suitable for structuring a database of complex engineering artifacts that evolve across multiple representations and over time and the operations through which such artifact descriptions are created and modified. There have been many proposals for new models and mechanisms to support such concepts within database data models in general and engineering data models in particular; here we not only describe such proposals; we also unify them. We do not propose yet another model but provide a common terminology and collection of mechanisms that underlie any approach for representing engineering design information in a database. The key remaining challenge is to construct a single framework, based on these mechanisms, which can be tailored for the needs of a given version environment.
Adaptive body bias for reducing impacts of die-to-die and within-die parameter variations on microprocessor frequency and leakage (2002)

Bidirectional adaptive body bias (ABB) is used to compensate for die-to-die parameter variations by applying an optimum pMOS and nMOS body bias voltage to each die which maximizes the die frequency subject to a power constraint. Measurements on a 150 nm CMOS test chip which incorporates on-chip ABB, show that ABB reduces variation in die frequency by a factor of seven, while improving the die acceptance rate. An enhancement of this technique, that compensates for within-die parameter variations as well, increases the number of dies accepted in the highest frequency bin. ABB is therefore shown to provide bin split improvement in the presence of increasing process parameter variations.
Promethazine Plus Sumatriptan in the Treatment of Migraine: A Randomized Clinical Trial (2013)

This is the first prospective clinical trial to demonstrate that multimechanism therapy for migraine, combining a triptan and an antiemetic agent, is well tolerated and offers improved clinical benefits compared with monotherapy.
Isolation and characterization of an extremely basic protein from adenovirus type 5 (1976)

By starch-gel electrophoresis and a staining method that is highly sensitive for argininyl residues, adenovirus type 5 was found to contain two minor basic polypeptides of extreme cathodic mobility in addition to the two known core proteins. The fastest-migrating polypeptide, named mu protein, and the second fastest polypeptide are found in adenovirions and virus-infected KB cells but not in top components or in uninfected cells. The top components and infected cells contain an additional basic polypeptide, presumably P-VII, that migrates slightly slower than polypeptide VII. None of the basic polypeptides of adenovirions was electrophoretically identical to the host histone. The basic proteins of adenovirions were purified by urea phosphocellulose column chromatography and characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The two minor basic core proteins, mu and another component, have similar mobilities in sodium dodecyl sulfate-polyacrylamide gels as a complex of polypeptides X-XII. After further purification on a Sephadex G-75 column, the mu protein was found to have a molecular weight of about 4,000. Amino acid analysis showed that the mu protein lacks tryptophan and 69% of the total amino acid residues are basic, that is, 54% arginine, 13% histidine, and 2% lysine. Only eight amino acids seem to contribute to make the mu polypeptide. There are 125 copies of the mu polypeptide per 1,000 copies of polypeptide VII in a virion.
Targeting lentiviral vectors to specific cell types in vivo (2006)

We have developed an efficient method to target lentivirus-mediated gene transduction to a desired cell type. It involves incorporation of antibody and fusogenic protein as two distinct molecules into the lentiviral surface. The fusogen is constructed by modifying viral envelope proteins, so that they lack the ability to bind to their cognate receptor but still retain the ability to trigger pH-dependent membrane fusion. Thus, the specificity of such a lentiviral vector is solely determined by the antibody, which is chosen to recognize a specific surface antigen of the desired cell type. This specific binding then induces endocytosis of the surface antigen, bringing the lentivirus into an endosome. There, the fusogen responds to the low pH environment and mediates membrane fusion, allowing the virus core to enter the cytosol. Using CD20 as a target antigen for human B cells, we have demonstrated that this targeting strategy is effective both in vitro and in intact animals. This methodology is flexible and can be extended to other forms of cell type-specific recognition to mediate targeting. The only requirement is that the antibody (or other binding protein) must be endocytosed after interaction with its cell surface-binding determinant.
Network coding for large scale content distribution (2005)

We propose a new scheme for content distribution of large files that is based on network coding. With network coding, each node of the distribution network is able to generate and transmit encoded blocks of information. The randomization introduced by the coding process eases the scheduling of block propagation, and, thus, makes the distribution more efficient. This is particularly important in large unstructured overlay networks, where the nodes need to make block forwarding decisions based on local information only. We compare network coding to other schemes that transmit unencoded information (i.e. blocks of the original file) and, also, to schemes in which only the source is allowed to generate and transmit encoded packets. We study the performance of network coding in heterogeneous networks with dynamic node arrival and departure patterns, clustered topologies, and when incentive mechanisms to discourage free-riding are in place. We demonstrate through simulations of scenarios of practical interest that the expected file download time improves by more than 20-30% with network coding compared to coding at the server only and, by more than 2-3 times compared to sending unencoded information. Moreover, we show that network coding improves the robustness of the system and is able to smoothly handle extreme situations where the server and nodes leave the system.
A risk factor for atherosclerosis: triglyceride-rich lipoproteins. (2001)

Compelling evidence from meta-analysis of a number of clinical studies on a large aggregate of patients has established an increased level of triglycerides as an independent risk factor for atherosclerotic heart disease. The finding of triglyceride-rich lipoproteins in human atheromata has provided substantial pathophysiologic evidence for a direct role in atherogenesis. Hypertriglyceridemia is commonly embedded in the context of a metabolic syndrome that includes central obesity, insulin resistance, low levels of HDL cholesterol, and often hypertension. Hypertriglyceridemia also appears to underlie the phenomenon of small dense LDL in most instances. Therapeutic interventions must be directed at underlying obesity, insulin resistance, and diabetes when present, as well as addressing metabolic determinants of dyslipidemia per se. Diet, exercise, weight loss, and avoidance of alcohol are the cornerstones of treatment. The choice of medication should be based on the lipoprotein phenotype. Niacin, fibric acid derivatives, and omega-3 fatty acids are most useful in treating severe hypertriglyceridemia. HMG-CoA reductase inhibitors are useful in some phenotypes with moderately increased triglyceride levels. Evidence from a number of clinical trials indicates that mitigation of risk of coronary heart disease, and possibly stroke, can be effected by reducing levels of plasma triglycerides.
Prediction of the Coding Sequences of Unidentified Human Genes. VIII. 78 New cDNA Clones from Brain Which Code for Large Proteins in vitro (1997)

As a part of our project for accumulating sequence information of the coding regions of unidentified human genes, we herein report the sequence features of 78 new cDNA clones isolated from human brain cDNA libraries as those which may code for large proteins. The sequence data showed that the average size of the cDNA inserts and their open reading frames was 6.0 kb and 2.8 kb (925 amino acid residues), respectively, and these clones produced the corresponding sizes of protein products in an in vitro transcription/translation system. Homology search against the public databases indicated that the predicted coding sequences of 68 genes contained sequences similar to known genes, 69% of which (47 genes) were related to cell signaling/communication, nucleic acid management, and cell structure/motility. The expression profiles of these genes in 14 different tissues have been analyzed by the reverse transcription-coupled polymerase chain reaction method, and 8 genes were found to be predominantly expressed in the brain.
The Herpes Simplex Virus Thymidine Kinase Gene as a Conditional Negative-Selection Marker Gene in Arabidopsis thaliana (1994)

The human herpes simplex virus thymidine kinase type 1 gene (HSVtk) acts as a conditional lethal marker in mammalian cells. The HSVtk-encoded enzyme is able to phosphorylate certain nucleoside analogs (e.g. ganciclovir, an antiherpetic drug), thus converting them to toxic DNA replication inhibitors. The utility of HSVtk as a conditional negative-selection marker was explored in Arabidopsis thaliana (L.) Heynh. HSVtk was introduced into Arabidopsis by Agrobacterium-mediated transformation. Transgenic plants were morphologically indistinguishable from wild type and exhibited normal fertility. Ganciclovir at 10(-5) to 10(-4) M drastically reduced shoot regeneration on transgenic, HSVtk+ root explants or callus formation on HSVtk+ leaf explants but did not affect the wild-type cultures. There was a 35-fold reduction in shoot regeneration 8 d after transfer to shoot-induction medium. Negative selection against HSVtk activity along with kanamycin selection was also efficient in Agrobacterium-mediated gene transfer experiments. Shoot regeneration was 25 times lower on double-selective (ganciclovir plus kanamycin) plates than in the kanamycin control. This regeneration rate in double-selective plates is in the range of the frequency of shoots normally escaping kanamycin selection in Arabidopsis cultures.
Inter-mode crosstalk compensation for radio orbital angular momentum multiplexing systems under misaligned condition using multiple-input multiple-output techniques (2016)

Inter-mode crosstalk compensation in radio orbital angular momentum (OAM) multiplexing systems with misalignment between transmitters and receivers are investigated by utilizing the multiple-input multiple-output (MIMO) analytical model. Both the zero-forcing (ZF) and minimum-mean-square-error (MMSE) compensation schemes are analysed under the misaligned conditions including off-axis and non-parallel cases. The simulation results show that system performance is significantly improved after compensation than that without compensation in both of the off-axis and non-parallel cases.
Slab-coupled 1.3-μm semiconductor laser with single-spatial large-diameter mode (2002)

A high brightness semiconductor diode laser structure, which utilizes a slab-coupled optical waveguide region to achieve several potentially important advances in performance, is proposed and experimentally demonstrated using a simple rib waveguide in an InGaAsP-InP quantum-well structure operating at 1.3-μm wavelength. These lasers operate in a large low-aspect-ratio lowest-order spatial mode, which can be butt coupled to a single-mode fiber with high coupling efficiency.
Impact of recent screening on predicting the outcome of prostate cancer biopsy in men with elevated prostate‐specific antigen (2010)

Previous participation in PSA screening dramatically changed the performance of statistical models that were designed to predict biopsy outcome. A 4-kallikrein panel was able to predict prostate cancer in men who had a recent screening history and provided independent confirmation that multiple kallikrein forms contribute important diagnostic information for men with elevated PSA. Cancer
The Bioperl Toolkit: Perl Modules for the Life Sciences (2002)

The Bioperl project is an international open-source collaboration of biologists, bioinformaticians, and computer scientists that has evolved over the past 7 yr into the most comprehensive library of Perl modules available for managing and manipulating life-science information. Bioperl provides an easy-to-use, stable, and consistent programming interface for bioinformatics application programmers. The Bioperl modules have been successfully and repeatedly used to reduce otherwise complex tasks to only a few lines of code. The Bioperl object model has been proven to be flexible enough to support enterprise-level applications such as EnsEMBL, while maintaining an easy learning curve for novice Perl programmers. Bioperl is capable of executing analyses and processing results from programs such as BLAST, ClustalW, or the EMBOSS suite. Interoperation with modules written in Python and Java is supported through the evolving BioCORBA bridge. Bioperl provides access to data stores such as GenBank and SwissProt via a flexible series of sequence input/output modules, and to the emerging common sequence data storage format of the Open Bioinformatics Database Access project. This study describes the overall architecture of the toolkit, the problem domains that it addresses, and gives specific examples of how the toolkit can be used to solve common life-sciences problems. We conclude with a discussion of how the open-source nature of the project has contributed to the development effort.