gebhart/patrepeval huggingface dataset:
PicoServer (2006)

In this paper, we show how 3D stacking technology can be used to implement a simple, low-power, high-performance chip multiprocessor suitable for throughput processing. Our proposed architecture, PicoServer, employs 3D technology to bond one die containing several simple slow processing cores to multiple DRAM dies sufficient for a primary memory. The 3D technology also enables wide low-latency buses between processors and memory. These remove the need for an L2 cache allowing its area to be re-allocated to additional simple cores. The additional cores allow the clock frequency to be lowered without impairing throughput. Lower clock frequency in turn reduces power and means that thermal constraints, a concern with 3D stacking, are easily satisfied.The PicoServer architecture specifically targets Tier 1 server applications, which exhibit a high degree of thread level parallelism. An architecture targeted to efficient throughput is ideal for this application domain. We find for a similar logic die area, a 12 CPU system with 3D stacking and no L2 cache outperforms an 8 CPU system with a large on-chip L2 cache by about 14% while consuming 55% less power. In addition, we show that a PicoServer performs comparably to a Pentium 4-like class machine while consuming only about 1/10 of the power, even when conservative assumptions are made about the power consumption of the PicoServer.
Urine-activated paper batteries for biosystems (2005)

The first urine-activated laminated paper batteries have been demonstrated and reported in this paper. A simple and cheap fabrication process for the paper batteries has been developed which is compatible with the existing plastic laminating technologies or plastic molding technologies. In this battery, a magnesium (Mg) layer and copper chloride (CuCl) in the filter paper are used as the anode and the cathode, respectively. A stack consisting of a Mg layer, CuCl-doped filter paper and a copper (Cu) layer sandwiched between two plastic layers is laminated into the paper batteries by passing through the heating roller at 120 °C. The paper battery is tested and it can deliver a power greater than 1.5 mW. In addition, these urine-activated laminated paper batteries could be integrated with bioMEMS devices such as home-based health test kits providing a power source for the electronic circuit.
Imaging with electricity: Report of the European Concerted Action on Impedance Tomography (1997)

(1997). Imaging with electricity: Report of the European Concerted Action on Impedance Tomography. Journal of Medical Engineering & Technology: Vol. 21, No. 6, pp. 201-232.
Inhibition of Irritation and Contact Hypersensitivity by Phenoxyacetic Acid Methyl Ester in Mice (2000)

New anti-irritant treatments are required to prevent irritation and sensitization reactions to consumer medicines and dermatological drugs. We report here that phenoxyacetic acid methyl ester (PAME) is an effective agent to prevent and treat irritant and allergic contact dermatitis. Balb/c mice skin-treated with 1% PAME do not lose weight relative to vehicle-treated mice, nor is it irritating to mouse skin. Topical PAME prevents skin irritation to a wide variety of irritants including: arachidonic acid, capsaicin, sodium lauryl sulfate (SLS), disodium laureth sulfosuccinate and tetradecanoylphorbol-13-acetate. Histological studies showed that 1% PAME greatly diminished dermal neutrophilic infiltration and dermal capillary vessel dilation, and prevented epidermal hyperproliferation and hyperkeratosis that accompanies detergent (SLS)-induced skin irritation. Topical PAME inhibited ear swelling following ear challenge during the elicitation phase of contact hypersensitivity in mice sensitized with 1-chloro-2, 4-dinitrochlorobenzene (DNCB), oxazolone and the hair coloring dye rho-phenylenediamine (PPD). Finally, topical administration of 1% PAME prior to PPD or DNCB sensitization prevented the induction phase of contact hypersensitivity. These results indicate that PAME represents a potential new category of potent topical anti-inflammatory agents.
Cambio estructural en los sistemas de aseguramiento agropecuario y su impacto en el estado de jalisco (1990)

Un aspecto central del Plan Nacional de Desarro­llo 1989-1994 es la modernizacion de la economia y de los sectores que la conforman. En el caso del sec­tor agropecuario, para lograrlo se contempla como es­trategia desincorporar entidades publicas que ya cum­plieron con los objetivos para los que fueron creadas. Respecto de las instituciones de credito y seguro del sector, el plan establece que ... se revisaran a fondo las politicas de credito y seguros al campo, de tal for­ma que dejen de ser vias de subsidio indiscriminadas y se conviertan en instrumentos efectivos de fomento a la produccion y el bienestar de los campesinos. Esta revision supondra necesarimente la eliminacion de practicas indebidas y sistemas ineficientes de traba­jo.1 De esta forma, la Aseguradora Nacional Agrico­la y Ganadera (ANAGSA), que desde hace 29 anos fungia como la unica institucion oficial destinada al aseguramiento agropecuario, fue sometida a revision y en febrero de 1990 se plantea como necesaria su li­quidacion.
OpenMath, MathML, and XSL (2000)

article Free Access Share on OpenMath, MathML, and XSL Author: David Carlisle The Numerical Algorithms Group, Wilkinson House, Jordan Hill Rd, Oxford The Numerical Algorithms Group, Wilkinson House, Jordan Hill Rd, OxfordView Profile Authors Info & Claims ACM SIGSAM BulletinVolume 34Issue 2June, 2000 pp 6–11https://doi.org/10.1145/362001.362011Online:01 June 2000Publication History 6citation378DownloadsMetricsTotal Citations6Total Downloads378Last 12 Months21Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Altered Apoptosis Pathways in Mantle Cell Lymphoma (2003)

Mantle cell lymphoma (MCL) is an aggressive subentity of non-Hodgkin lymphoma (NHL), responds poorly to therapy, is resistant to current therapeutic strategies and has the shortest survival of all lymphoma entities. The blastoid variant of mantle cell lymphoma (MCL-BV) has an even worse clinical outcome. The mechanisms of neoplastic transformation from normal mantle cells and the relationship to the rare blastoid variant are poorly understood. BCL2 is overexpressed in indolent B-cell NHL including MCL. In addition, other proteins of the BCL-family are overexpressed in MCL like BCLX, whereas the expression of BAX and BAK was not elevated in MCL. BCL2 independent apoptotic pathways are altered in MCL. CD40, which can mediate B-cell survival, is overexpressed in MCL. Furthermore, the expression of FAS which is known to be pro-apoptotic is markedly decreased favoring the CD40 mediated cell survival pathway in these cells. Besides overexpression of cyclin D1, the cyclin dependent kinases (CDK2 and CDK4) are highly expressed in MCL resulting in the phosphorylation of RB1, E2F release, and the cell cycle progression. The new technique of gene expression analysis by microarrays promotes more insight into the pathogenesis of MCL and discovery of altered cell signaling pathways, and the ability to predict subgroups of patients with different risk and probability of response to treatment.
Preparation and palladium-catalysed arylation of indolylzinc halides (1996)

Indolylzinc halides are prepared by two methods: transmetallation of indolyllithiums with zinc chloride and oxidative addition of active zinc to iodoindoles. The palladium-catalysed reaction of the indolylzinc halides provides a practical method for synthesizing arylindoles.
Nanotechnology‐based molecular photoacoustic and photothermal flow cytometry platform for in‐vivo detection and killing of circulating cancer stem cells (2009)

In-vivo multicolor photoacoustic (PA) flow cytometry for ultrasensitive molecular detection of the CD44+ circulating tumor cells (CTCs) is demonstrated on a mouse model of human breast cancer. Targeting of CTCs with stem-like phenotype, which are naturally shed from parent tumors, was performed with functionalized gold and magnetic nanoparticles. Results in vivo were verified in vitro with a multifunctional microscope, which integrates PA, photothermal (PT), fluorescent and transmission modules. Magnet-induced clustering of magnetic nanoparticles in individual cells significantly amplified PT and PA signals. The novel noninvasive platform, which integrates multispectral PA detection and PT therapy with a potential for multiplex targeting of many cancer biomarkers using multicolor nanoparticles, may prospectively solve grand challenges in cancer research for diagnosis and purging of undetectable yet tumor-initiating cells in circulation before they form metastasis.
Enhancement of Dengue Virus Infection in Monocytes by Flavivirus Antisera (1980)

Enhanced dengue 2 virus (D2V) infection in suspension cultures of human peripheral blood mononuclear phagocytes (PBL) produced by subneutralizing concentrations of dengue antisera has been described previously. In this study, the enhancement phenomenon was found to be a general property of representative flavivirus antisera. All except one of 24 antisera, which had been raised by 1-3 injections of flaviviruses in rabbits, enhanced the growth of dengue 2 virus in human PBL. Flavivirus antisera showing the greatest level of cross-reactivity against a battery of 42 flavivirus antigens in the hemagglutination-inhibition test were most potent in enhancing dengue replication in PBL cultures. Cross-neutralizing reactivity did not relate to enhanced D2V infection. However nearly one-half of studied flavivirus antisera neutralized D2V at dilutions of 1:10 or 1:20. Heterotypic D2V neutralizing antibody could serve as a "brake" on infection enhancement in vivo. Observations should be made in the field to look for possible enhancement of dengue infection in heterotypic flavivirus immunes.
Lipoxygenase Inhibitors Prevent Lung Carcinogenesis and Inhibit Non-Small Cell Lung Cancer Growth (1998)

The effects of lipoxygenase inhibitors were investigated using human lung cancer cell lines and A/J mice. By RT-PCR, 5-, 12-, and 15-lipoxygenase mRNA was detected in NSCLC cells. NDGA inhibited 5-LO activity in adenocarcinoma cell line NCI-H1264. Using an MTT assay, NDGA, MK591 and AA861 inhibited the growth of NSCLC cell lines tested with IC50 values of 3, 2, and 7 microM, respectively. Using a clonogenic assay, 10 microM NDGA significantly reduced NSCLC colony number. NDGA significantly slowed NSCLC xenograft growth in nude mice. When the tumors were excised and analyzed, nude mice treated with NDGA had significantly more apoptotic figures than did untreated tumors. A/J mice treated with urethane developed adenomas after 4 months and NDGA administration significantly reduced lung adenoma number. These data indicate that lipoxygenase inhibitors inhibit lung cancer growth and prevent lung carcinogenesis.
Neutralization of Endotoxin In Vitro and In Vivo by a Human Lactoferrin-Derived Peptide (1999)

Endotoxin (lipopolysaccharide [LPS]) is the major pathogenic factor of gram-negative septic shock, and endotoxin-induced death is associated with the host overproduction of tumor necrosis factor alpha (TNF-alpha). In the search for new antiendotoxin molecules, we studied the endotoxin-neutralizing capacity of a human lactoferrin-derived 33-mer synthetic peptide (GRRRRSVQWCAVSQPEATKCFQWQRNMRKVRGP; designated LF-33) representing the minimal sequence for lactoferrin binding to glycosaminoglycans. LF-33 inhibited the coagulation of the Limulus amebocyte lysate and the secretion of TNF-alpha by RAW 264.7 cells induced by lipid A and four different endotoxins with a potency comparable to that of polymyxin B. The first six residues at the N terminus of LF-33 were critical for its antiendotoxin activity. The endotoxin-neutralizing capacity of LF-33 and polymyxin B was attenuated by human serum. Coinjection of Escherichia coli LPS (125 ng) with LF-33 (2.5 microg) dramatically reduced the lethality of LPS in the galactosamine-sensitized mouse model. Significant protection of the mice against the lethal LPS challenge was also observed when LF-33 (100 microg) was given intravenously after intraperitoneal injection of LPS. Protection was correlated with a reduction in TNF-alpha levels in the mouse serum. These results demonstrate the endotoxin-neutralizing capability of LF-33 in vitro and in vivo and its potential use for the treatment of endotoxin-induced septic shock.
Contents (2013)

This book is a history of an illusion. It is also a history of the dream that preceded the illusion. The book discusses statistics as the field of tension between the scientific claims of neutrality and universality on the one hand and the political and economic reality of the conflicting interests of nation-states on the other. The various paths of state- and nation-building that European countries traversed in the nineteenth century are recognisable in the objectives of government statistics and are reflected in the topics selected for statistical study and in the categories used in the research. Each congress was clearly dominated by the specific interests of the country in which the statisticians convened. The book shows in each case how the organisation of government statistics and national concerns influenced the international agenda. It describes the perceptions, goals and dilemmas of the protagonists and their contact with each other, and in so doing unravels the complex relationships between science, government and society, wherever possible from their point of view. The genesis of international statistics was inspired by a desire for reform. Belgium's pioneering role in the European statistical movement was informed both by its liberal polity and the special status of statistics within it, and by Adolphe Quetelet's key position as an intellectual. The consolidation of the Grand Duchy of Baden, a new medium-sized state in the Rhine Confederation and later in the German Confederation, offered great opportunities for the development of official statistics.
Optical Biosensors Based on Plasmonic Nanostructures: A Review (2016)

This paper reviews fundamentals of optical affinity biosensors based on plasmonic nanostructures and discusses recent advances in the development of this technology, including plasmonic nanostructures and surface plasmon phenomena, advances in sensor instrumentation, and functional coatings. Examples of applications for both the detection of chemical and biological substances as well as the investigation of biomolecular interactions are also given.
Optimization modeling of single-chain antibody against hepatoma based on similarity algorithm. (2015)

The purposes was to establish optimal modeling of single-chain antibody molecules based on similarity algorithm and seek the connecting peptides that had the minimal effect on the structure and bioactivity of the variable region of heavy chain (VH) and that of light chain (VL) in a single-chain antibody against liver cancer. After the Linker with different lengths (n=0~7) had been added into single chain fragment variable (ScFv), modeling of the overall sequences of VH, VL and ScFv were conducted respectively. Meanwhile, the peptide chain structure of (Gly4Ser)n was adopted for the connecting peptide. Then the spatial spherical shell layer alignment algorithm based on spherical polar coordinates was utilized for comparing the structural similarity of VH and VL before and after adding connecting peptide. Equally, in order to determine the stability of VH and VL, MATLAB was applied for analysis of the fore and aft distances and the diffusion radius. Indirect ELISA method was used to detect single-chain antibody immunological activity of Linker with different lengths. The MTT assay was utilized for the examination of the inhibition rate of single-chain antibody with different lengths of Linker to liver cancer cell. When n=4, the structural similarity between VH together with VL and their original ones was the highest. When n=3, the influence of connecting peptide on the stability of VH and VL was minimum. When n>3, the fore and aft distances changed little due to the increase and fold of the length of peptide chain. The results of ELISA detection showed that when n=4, affinity of single chain antibody to liver cancer cells was much higher. The MTT test also indicated that when n=4, the inhibition rate of the connecting peptide on hepatoma carcinoma cell reached the highest, and that came second when n=3. When n=4, the structural stability and biological functions of anti-hepatoma single-chain antibody were both favorable. This study has provided a basis for the design and construction of single-chain antibody.
Mining search engine query logs for query recommendation (2006)

This paper presents a simple and intuitive method for mining search engine query logs to get fast query recommendations on a large scale industrial strength search engine. In order to get a more comprehensive solution, we combine two methods together. On the one hand, we study and model search engine users' sequential search behavior, and interpret this consecutive search behavior as client-side query refinement, that should form the basis for the search engine's own query refinement process. On the other hand, we combine this method with a traditional content based similarity method to compensate for the high sparsity of real query log data, and more specifically, the shortness of most query sessions. To evaluate our method, we use one hundred day worth query logs from SINA' search engine to do off-line mining. Then we analyze three independent editors evaluations on a query test set. Based on their judgement, our method was found to be effective for finding related queries, despite its simplicity. In addition to the subjective editors' rating, we also perform tests based on actual anonymous user search sessions.
Novel approach to nonlinear/non-Gaussian Bayesian state estimation (1993)

An algorithm, the bootstrap filter, is proposed for implementing recursive Bayesian filters. The required density of the state vector is represented as a set of random samples, which are updated and propagated by the algorithm. The method is not restricted by assumptions of linearity or Gaussian noise: it may be applied to any state transition or measurement model. A simulation example of the bearings only tracking problem is presented. This simulation includes schemes for improving the efficiency of the basic algorithm. For this example, the performance of the bootstrap filter is greatly superior to the standard extended Kalman filter.
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus (1958)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Isolation of a Second Antibiotic from Streptomyces hygroscopicusRobert L. Mann and W. W. BromerCite this: J. Am. Chem. Soc. 1958, 80, 11, 2714–2716Publication Date (Print):June 1, 1958Publication History Published online1 May 2002Published inissue 1 June 1958https://pubs.acs.org/doi/10.1021/ja01544a032https://doi.org/10.1021/ja01544a032research-articleACS PublicationsRequest reuse permissionsArticle Views257Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
T4-induced α- and β-glucosyltransferase: cloning of the genes and a comparison of their products based on sequencing data (1985)

Bacteriophage T4 alpha- and beta-glucosyltransferases link glucosyl units to the 5-HMdC residues of its DNA. The monoglucosyl group in alpha-linkage predominates over the one in beta linkage. Having recently reported on the nucleotide sequence of gene alpha gt (1) we now determined the nucleotide sequence of gene beta gt. The genes were each cloned on a high expression vector under the control of the lambda pL promoter. After thermo-induction the proteins were isolated and purified to homogeneity. To verify that the translational starting sites and the proposed reading frames are effective in vivo the sequence of the first 31 amino acid residues from gp alpha gt and the first 30 amino acid residues from gp beta gt were determined by Edman degradation. The primary structures of the two proteins seem to have only limited structural similarities. The results are discussed comparing secondary structure predictions and homologies with other proteins from the protein sequence database of the Protein Identification Resource.
A Randomized, Controlled Trial of Prophylactic Ganciclovir for Cytomegalovirus Pulmonary Infection in Recipients of Allogeneic Bone Marrow Transplants (1991)

In recipients of allogeneic bone marrow, asymptomatic CMV infection of the lung is a major risk factor for subsequent CMV interstitial pneumonia. Prophylactic ganciclovir is effective in preventing the development of CMV interstitial pneumonia in patients with asymptomatic infection.
Wireless Body Sensor Network for Continuous Cuff-less Blood Pressure Monitoring (2006)

This paper describes an unobtrusive IEEE 802.15.4-based wireless body sensor network (BSN) that enables continuous cuff-less blood pressure monitoring, opening up new perspectives for hypertension diagnosis and treatment, cardio-vascular event detection, and stress monitoring. We estimate the arterial blood pressure based on the pulse arrival time (PAT), which is measured with a waist electrocardiogram (ECG) and an ear photo-plethysmogram (PPG). The PAT measurement requires the synchronization of the wireless sensors' clocks. This is achieved with the flooding time synchronization protocol (FTSP). The evaluation of both the implemented time synchronization and the robustness of the wireless data transmission yielded promising results. Future work will include the study of packet collisions in synchronized IEEE 802.15.4 networks, the enhancement of the BSN with additional context-providing sensors (e.g. accelerometer, magnetometer, thermistor), and the integration of the blood pressure estimation algorithm in a wireless sensor unit.
Infrared photovoltaic detectors from ion-implanted CdxHg1−xTe (1973)

We have fabricated n-p photovoltaic detectors in CdxHg1−xTe using aluminum implantation to create the n-type region. Implanted diodes made in this material with a composition x = 0.18, which corresponds to a band gap of 0.1 eV, had a zero-bias resistance of 1 kΩ at 77°K for a 200 × 250-μm sensitive area. The spectral response was almost flat in the range 4–12 μm with a quantum efficiency as high as 57% at 10.6 μm. The measured detectivity for a 30° field of view is 7.3 × 1010 cm Hz1/2 W−1 at 10.6 μm. This is one of the highest detectivities ever reported at this wavelength. Finally, the frequency response of these diodes used in a heterodyne detection system operating with a CO2 laser was 1 GHz.