gebhart/patrepeval huggingface dataset:
The Vogel−Fulcher−Tamman Equation Investigated by Atomistic Simulation with Regard to the Adam−Gibbs Model (2007)

Many efforts in experimental and theory are dedicated to study the puzzling problem of glass transition. With the involvement of molecular modeling, a fresh look at this intricate phenomenon was taken. Nevertheless, the difficulty to accurately probe all the domains of times necessary to describe this process still remains. Moreover, using a full-atomic description to account for equilibrated systems has been called into question. However, such depiction offers a special regard since it could deal with small modifications in the polymer architecture. From an appropriate selection of phase space, it was shown that atomistic simulation was able to link simulated and experimental glass transition temperatures of vinylic polymers using the established Williams−Landel−Ferry equation. Consequently, atomic insight into the glass transition phenomenon can be gained from a comparison of simulated data with actual models and experimental data. In this paper, the different parameters intervening in the Vogel−Fulcher−Tamman equation stemming from the local dynamics of a series of vinylic polymers are thus compared. Their behavior yields an atomistic viewpoint of the Adam−Gibbs model.
Verification for large space structures (1985)

The primary concern for verification is the dynamic characteristics of the space structure related to the control and sensor/actuator location. Properties such as modal density, range of natural frequencies, and modal displacements at the sensor/actuator location are considered and are simulated for the verification of the structure/control closed loop system. A space beam is studied in zero gravity environment and in a 1 G gravity environment, along with their governing equations.
Reflectivity measurements of water and dioxane mixtures using a 100 GHz Gunn diode source (2013)

Terahertz (THz) sensing has shown potential as a novel imaging modality in medical applications due to
its high water sensitivity. The design of medical THz sensing systems and their successful application to
 in vivo settings has attracted recent interest to the field, and highlighted the need for improved
understanding of the interaction of THz waves with biological tissues. This paper explores the modeling
of composite materials which combine strongly-interacting water with weakly-interacting species such as
those that are common to biological tissues. The Bruggeman, Maxwell-Garnett, and power law effective
media models are introduced and discussed. A reflection-mode 100 GHz Gunn diode sensing system was
used to measure the reflectivity of solutions of water and dioxane as a function of relative concentration,
and the results were compared with the predictions of the Maxwell-Garnett, power law, and Bruggeman
mixing theories. The Maxwell-Garnett model fit poorly to experimental data on near-equal mixtures of
water and dioxane and improved when the concentration of water exceeded ~55% or was below ~15%.
The first-order power law model fit poorly to experimental data across the entire range except at nearpure
solutions. Power law models employing 1/2 and 1/3 terms improved goodness of fit, but did not
match the accuracy of the Bruggeman model. The Bruggeman provided the best fit to experimental data
model as compared to Maxwell-Garnett and the power models and accurately predicted the solution
reflectivity through the whole range of concentrations. This analysis suggests that the Bruggeman model
may offer improved accuracy over more conventional dielectric mixing models when developing
simulation tools for THz reflectometry of hydrated biological tissues.
COMPARISON OF ROBOTIC-ASSISTED AND MANUAL IMPLANTATION OF A PRIMARY TOTAL HIP REPLACEMENT (2003)

The robotic-assisted technology had advantages in terms of preoperative planning and the accuracy of the intraoperative procedure. Disadvantages were the high revision rate; the amount of muscle damage, which we believe was responsible for the higher dislocation rate; and the longer duration of surgery. This technology must be further developed before its widespread usage can be justified.
Engineering Microenvironments for Embryonic Stem Cell Differentiation to Cardiomyocytes (2009)

Embryonic stem cells and induced pluripotent stem cells have the potential to be a renewable source of cardiomyocytes for use in myocardial cell replacement strategies. Although progress has been made towards differentiating stem cells to specific cell lineages, the efficiency is often poor and the number of cells generated is not suitable for therapeutic usage. Recent studies demonstrated that controlling the stem cell microenvironment can influence differentiation. Components of the extracellular matrix are important physiological regulators and can provide mechanical cues, direct differentiation and improve cell engraftment into damaged tissue. Bioreactors are used to control the microenvironment and produce large numbers of desired cells. This article describes recent methods to achieve cardiomyocyte differentiation by engineering the stem cell microenvironment. Successful translation of stem cell research to therapeutic applications will need to address large-scale cardiomyocyte differentiation and purification, assessment of cardiac function and synchronization, and safety concerns.
Systemic effects of transdermal testosterone for the treatment of microphallus in children (2001)

When using testosterone ointment as a treatment for microphallus, it should be borne in mind that this application has systemic effects.
XML three-way merge as a reconciliation engine for mobile data (2003)

Optimistic replication approaches are often employed on mobile devices, which raises the need for reconciliation of concurrently modified data. We propose that three-way merging algorithms, in particular those that are able to process tree-structured data in XML format, make good candidates for a generic data reconciliation engine on mobile devices.By exchanging data through XML files we impose minimal constraints on application design and are able to offer reconciliation services to a large number of existing applications. Reconciliation support can be added to an application in several increments, allowing application developers to choose a suitable level of support compared to implementation effort. We give two examples of reconciliation by three-way merging of XML.
Combined cyclophosphamide, vincristine, and prednisone therapy of malignant lymphoma (1971)

A combination of intravenous cyclophosphamide and vincristine (Oncovin) and oral prednisone (COP) was given every 2 weeks to 262 patients with disseminated Hodgkin's disease, lymphosarcoma, reticulum cell sarcoma, and follicular lymphoma. A complete remission was produced in 36% of patients with Hodgkin's disease, 50% of patients with lymphosarcoma, and 39% of patients with reticulum cell sarcoma. These remission rates are significantly superior to those produced by single agents. Patients who achieved a complete remission were randomly allocated to monthly COP (maintained remission) or to no treatment (unmaintained remission). The median duration of maintained remission was longer than unmaintained remission for Hodgkin's disease (42 weeks vs. 19 weeks) and lymphosarcoma (49 weeks vs. 21 weeks) but not for reticulum cell sarcoma (24 weeks vs. 25 weeks). The duration of remission for patients with little or no prior therapy was compared to that for patients in a similar study in which single agents were used.4 For lymphosarcoma and reticulum cell sarcoma, remissions maintained with COP were longer than remissions maintained with cyclophosphamide. For Hodgkin's disease and lymphosarcoma, unmaintained remissions after COP induction were longer than after single agent induction. All parameters of response, that is, complete remission rate, duration of remission, and survival were adversely affected by major prior treatment with radiotherapy and chemotherapy. The initial response to treatment correlated positively with survival. The survival of patients with lymphosarcoma or reticulum cell sarcoma receiving COP treatment was significantly superior to a comparable group of patients treated sequentially with single agents.
Endoscopic Laser Surgery versus Serial Amnioreduction for Severe Twin-to-Twin Transfusion Syndrome (2004)

Endoscopic laser coagulation of anastomoses is a more effective first-line treatment than serial amnioreduction for severe twin-to-twin transfusion syndrome diagnosed before 26 weeks of gestation.
A signal space representation of fixed delay tree search for use with d=0 codes (2002)

This paper addresses the optimality of the fixed-delay tree search with decision feedback (FDTS/DF) detector for data without a minimum run length constraint. The evaluation is performed by comparing the minimum distance for FDTS/DF with the minimum distance associated with a maximum likelihood sequence detector (MLSD). Using this distance information, potential improvements through coding are addressed. An alternative realization to the direct implementation of FDTS/DF is considered by examining the detection process in the context of a signal space.
Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia (2005)

Thrombospondin 1 (TSP-1) is a matricellular protein that inhibits angiogenesis and causes apoptosis in vivo and in vitro in several cancerous cells and tissues. Here we identify TSP-1 as the molecule with the highest induction level at 3 hours of IR injury in rat and mouse kidneys subjected to ischemia/reperfusion (IR) injury using the DNA microarray approach. Northern hybridizations demonstrated that TSP-1 expression was undetectable at baseline, induced at 3 and 12 hours, and returned to baseline levels at 48 hours of reperfusion. Immunocytochemical staining identified the injured proximal tubules as the predominant sites of expression of TSP-1 in IR injury and showed colocalization of TSP-1 with activated caspase-3. Addition of purified TSP-1 to normal kidney proximal tubule cells or cells subjected to ATP depletion in vitro induced injury as demonstrated by cytochrome c immunocytochemical staining and caspase-3 activity. The deleterious role of TSP-1 in ischemic kidney injury was demonstrated directly in TSP-1 null mice, which showed significant protection against IR injury-induced renal failure and tubular damage. We propose that TSP-1 is a novel regulator of ischemic damage in the kidney and may play an important role in the pathophysiology of ischemic kidney failure.
Evidence for five divergent thioredoxin h sequences in Arabidopsis thaliana. (1995)

Five different clones encoding thioredoxin homologues were isolated from Arabidopsis thaliana cDNA libraries. On the basis of the sequences they encode divergent proteins, but all belong to the cytoplasmic thioredoxins h previously described in higher plants. The five proteins obtained by overexpressing the coding sequences in Escherichia coli present typical thioredoxin activities (NADP(+)-malate dehydrogenase activation and reduction by Arabidopsis thioredoxin reductase) despite the presence of a variant active site, Trp-Cys-Pro-Pro-Cys, in three proteins in place of the canonical Trp-Cys-Gly-Pro-Cys sequence described for thioredoxins in prokaryotes and eukaryotes. Southern blots show that each cDNA is encoded by a single gene but suggest the presence of additional related sequences in the Arabidopsis genome. This very complex diversity of thioredoxins h is probably common to all higher plants, since the Arabidopsis sequences appear to have diverged very early, at the beginning of plant speciation. This diversity allows the transduction of a redox signal into multiple pathways.
The Ultracentrifuge: Problems and Prospects* (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Ultracentrifuge: Problems and Prospects*Howard K. SchachmanCite this: Biochemistry 1963, 2, 5, 887–905Publication Date (Print):September 1, 1963Publication History Published online1 May 2002Published inissue 1 September 1963https://doi.org/10.1021/bi00905a001Request reuse permissionsArticle Views157Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (9 MB) Get e-Alertsclose Get e-Alerts
Association of activated properdin with complexes of properdin with C3 (1991)

An ELISA using antibody to properdin (P), followed by antibody to C3 to detect complexes of P with C3 (P-C3), detected low levels of P-C3 complexes in human serum and plasma samples. Incubating serum for 1 h at 37 degrees C increased the amount of P-C3 and diminished factor B hemolytic activity without altering total alternative pathway activity or C3 activity in serum. When P and C3 in incubated serum were analyzed by size exclusion HPLC, complexes of P-C3 were detected at retention times corresponding to molecular mass measuring in excess of 2 x 10(6) Da. Activation of serum with zymosan or cobra venom factor greatly increased the level of P-C3 and decreased alternative pathway hemolytic activity. Chromatography of proteins eluted from serum-treated zymosan detected a peak of P at 9.7 x 10(5) Da and a peak of P-C3 at 1.5 x 10(6) Da. Functional assays for activated properdin also revealed a peak of activity at 1.5 x 10(6) Da, congruent with the peak of P-C3. Native properdin was detected at 3.9 x 10(5) Da. When native properdin was added to properdin-depleted serum and incubated for 1 h at 37 degrees C, activated properdin was detected at the same position in the chromatograph as were P-C3 complexes. We conclude that incubation of serum at 37 degrees C produces complexes of P with C3, that exposure of serum to alternative pathway activators increases the amount of P-C3, and that generation of P-C3 complexes is associated with the presence of activated P.
Blood clearance in the mouse of an aglycosyl recombinant monoclonal antibody (1989)

Conference Article| December 01 1989 Blood clearance in the mouse of an aglycosyl recombinant monoclonal antibody EDWARD J. WAWRZYNCZAK; EDWARD J. WAWRZYNCZAK *Institute of Cancer Research, Sutton, Surrey SM2 5NG, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEOFFREY D. PARNELL; GEOFFREY D. PARNELL *Institute of Cancer Research, Sutton, Surrey SM2 5NG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALAN J. CUMBER; ALAN J. CUMBER *Institute of Cancer Research, Sutton, Surrey SM2 5NG, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER T. JONES; PETER T. JONES †M.R.C. Laboratory of Molecular Biology, Cambridge CB2 2QH, U.K. Search for other works by this author on: This Site PubMed Google Scholar GREG WINTER GREG WINTER †M.R.C. Laboratory of Molecular Biology, Cambridge CB2 2QH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1989) 17 (6): 1061–1062. https://doi.org/10.1042/bst0171061 Article history Received: June 15 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation EDWARD J. WAWRZYNCZAK, GEOFFREY D. PARNELL, ALAN J. CUMBER, PETER T. JONES, GREG WINTER; Blood clearance in the mouse of an aglycosyl recombinant monoclonal antibody. Biochem Soc Trans 1 December 1989; 17 (6): 1061–1062. doi: https://doi.org/10.1042/bst0171061 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: NIP, 3-iodo-4-hydroxy-5-nitrophenylacetate This content is only available as a PDF. © 1989 Biochemical Society1989 Article PDF first page preview Close Modal You do not currently have access to this content.
Shallow and Deep Convolutional Networks for Saliency Prediction (2016)

The prediction of salient areas in images has been traditionally addressed with hand-crafted features based on neuroscience principles. This paper, however, addresses the problem with a completely data-driven approach by training a convolutional neural network (convnet). The learning process is formulated as a minimization of a loss function that measures the Euclidean distance of the predicted saliency map with the provided ground truth. The recent publication of large datasets of saliency prediction has provided enough data to train end-to-end architectures that are both fast and accurate. Two designs are proposed: a shallow convnet trained from scratch, and a another deeper solution whose first three layers are adapted from another network trained for classification. To the authors' knowledge, these are the first end-to-end CNNs trained and tested for the purpose of saliency prediction.
Palmitoylation of Human EndothelinB (1997)

By site-directed mutagenesis, three cysteine residues (amino acids 402, 403, and 405) in the carboxyl terminus of human endothelinB (ETB) were identified as potential palmitoylation sites. Substitutions of all of the three cysteine residues with serine gave an unpalmitoylated mutant, C2S/C3S/C5S. When expressed in Chinese hamster ovary cells, C2S/C3S/C5S was localized on the cell surface, retained high affinities to ET-1 and ET-3, and was rapidly internalized when bound to the ligand. However, unlike the wild-type ETB, C2S/C3S/C5S transmitted neither an inhibitory effect on adenylate cyclase nor a stimulatory effect on phospholipase C, indicating a critical role of palmitoylation in the coupling with G proteins, regardless of the G protein subtypes. Truncation of the carboxyl terminus including Cys403/Cys405 gave a deletion mutant Delta403 that was palmitoylated on Cys402 and lacked the carboxyl terminus downstream to the palmitoylation site. Delta403 did transmit a stimulatory effect on phospholipase C via a pertussis toxin-insensitive G protein but it failed to transmit an inhibitory effect on adenylate cyclase. These results indicated a differential requirement for the carboxyl terminus downstream to the palmitoylation site in the coupling with G protein subtypes, i.e. it is required for the coupling with Gi but not for that with Gq.
Urodynamic Evaluation of Voiding Dysfunction in Diabetic Patients (1994)

In an attempt to evaluate the urodynamic parameters and the clinical features of urinary bladder dysfunction in patients with diabetes mellitus (DM), 62 diabetic patients’ clinical histories and laboratory data were analyzed and correlated with the parameters of urodynamic studies All 62 patients were symptomatic, with chief problems of urinary frequency (36 cases), urinary retention (16 cases), dysuria (23 cases) and urinary incontinence (9 cases). Some of them had more than one urinary symptom. These outcome did not permit accurate predication of the detrusor function solely from the clinical symptoms without urodynamic results.
There were only 19 patients (30.6%) who had a bladder capacity greater than 500 ml, and only 17 patients (27.4%) experienced a first sensation larger than 250 ml. Both poor (21 cases) and involuntary (18 cases) contractions of the detrusor were observed in the patient group. The relationship between DM control results and the detrusor function was statistically significant for those patients with a DM history of 10 years or less (p=0.019) but not for those with more than 10 years. Detrusor function did not correlate with DM duration in patients with both good and poor DM control results. 
This study found that diabetic cystopathy is not only hypotonic in nature. A combination of the patient’s history, symptom complex and urodynamic studies are required to evaluate and diagnose diabetic voiding dysfunction.
Diabetes, Plasma Insulin, and Cardiovascular Disease (2002)

In men with CHD and a low high-density lipoprotein cholesterol level, gemfibrozil use was associated with a reduction in major cardiovascular events in persons with diabetes and in nondiabetic subjects with a high fasting plasma insulin level.
Cystic fibrosis transmembrane conductance regulator activation stimulates endosome fusion in vivo. (1996)

Previous studies have suggested a role for cystic fibrosis transmembrane conductance regulator (CFTR) in the regulation of intracellular vesicular trafficking. A quantitative fluorescence method was used to test the hypothesis that CFTR expression and activation affects endosome-endosome fusion in intact cells. Endosomes from CFTR-expressing and control (vector-transfected) Swiss 3T3 fibroblasts were labeled by internalization with 4,4-difluoro-5,7-dimethyl-4-bora-3a, 4a-diaza-s-indacene (Bodipy)-avidin, a fluid-phase marker whose fluorescence increases approximately 8-fold upon biotin binding. Cells were washed, chased, and then labeled with biotin-albumin or biotin-transferrin. The fraction of Bodipy-avidin-labeled endosomes that fused with biotin-containing endosomes (f(fusion)) was quantified by ratio imaging microfluorimetry. Endosome fusion in unstimulated CFTR-expressing cells was similar to that in control cells. However, in CFTR-expressing cells activated by forskolin, ffusion was increased by 1.30 +/- 0.18- and 2.65 +/- 0.17-fold for a 0 and 10 min chase time between avidin and biotin-albumin pulses; f(fusion) also increased (1.32 +/- 0.11-fold) when biotin-transferrin replaced biotin-albumin. The stimulation of endosome fusion was not due to differences in rates of endocytosis or endosomal acidification. Endosome fusion was not stimulated by forskolin in Cl--depleted CFTR-expressing cells, suggesting that the increase in endosome fusion is due to the CFTR chloride channel activity. These results provide evidence that CFTR is involved in the regulation of endosome fusion and, thus, a possible basis for the cellular defects associated with cystic fibrosis.