gebhart/patrepeval huggingface dataset:
Power spectra requirements for wave-front-compensative systems* (1976)

The phase degradation of an optical wave front distorted by turbulence in the propagation medium may be corrected in a piecewise-linear fashion by using an array of small circular mirrors. An option in the correction scheme is to compensate for overall tilt separately. We have evaluated power spectra and variances of the piston and tilt motions of the mirror segments as well as the motion of the overall tilt corrector. The form of the spectra for any propagation medium is an aperture integral of the product of the phase-difference power spectrum, describing the medium, and a generalized transfer function, representing the aperture and its segments. In the case of low-power atmospheric propagation, the necessary propagation results are linear in turbulence strength; hence the path may be sectioned into a large number of thin slices. A set of standard curves is found to represent a generalized slice, and the differential contributions may be summed to represent any propagation path. The standard curves, further modeled in terms of power-law dependencies, are practical for use on a desk calculator.
Revisiting the Molecular Structure of Collagen (2008)

The triple helix is a specialized protein motif found in all collagens. Although X-ray diffraction studies of collagen began in the 1920s, the very small amount of data available from fiber diffraction of native collagen caused the determination of its molecular conformation to take a very long time. In the early 1950s, two plausible fiber periods of about 20 and 30 A were proposed, together with corresponding single-strand models having 7/2- and 10/3-helical symmetry, respectively. The first framework of the triple helix was proposed by Ramachandran and Kartha in 1955. In the same year, Rich and Crick proposed another structure with the same framework that avoided some of the steric problems of the first model. Their framework, which involved a triple-helical structure with a fiber period of 28.6 A and 10/3-helical symmetry, was exactly the same as one of two single-strand models for collagen proposed at that time, except for the number of strands. At that time, however, nobody considered the triple-strand model with the other framework, with a fiber period of 20 A and 7/2-helical symmetry, until Okuyama et al. detected this structure in the single crystal of (Pro-Pro-Gly)(10) in 1972. Although they proposed this structure as a new structural model for collagen in 1977, it has not been acknowledged as such, but instead has been regarded only as a model for a collagen-like peptide. In 2006, it was shown that both 7/2- and 10/3-helical models could explain X-ray diffraction data from native collagen quantitatively. Furthermore, during the past decade, many single crystals of collagen-model peptides have been analyzed at high resolution. The helical symmetries observed in these model peptides are very close to the ideal 7/2-helical symmetry, whereas no supporting data were found for the 10/3-helical model. This evidence strongly suggests that an average molecular structure of native collagen is the 7/2-helical model rather than the prevailing Rich and Crick (10/3-helical) model. Knowing the correct molecular structure, the driving force for the formation of a quarter-staggered structure in collagen fibrils will be elucidated in the near future by analysis incorporating the molecular structure of collagen and its amino acid sequence.
Molecular Cloning and Characterization of a Rat A1-Adenosine Receptor that is Widely Expressed in Brain and Spinal Cord (1991)

An A1-adenosine receptor has been cloned from a rat brain cDNA library using a probe generated by the polymerase chain reaction. The cDNA encodes a protein of 327 amino acids which is 91% identical to a recently cloned dog A1-adenosine receptor (RDC7). Expression of the rat cDNA in COS-6M and NIH 3T3 cells resulted in ligand binding and functional activity characteristics of an A1-adenosine receptor that is coupled to inhibition of adenylyl cyclase. Examination of the distribution of A1-adenosine receptor mRNA by Northern blot analysis showed that it is highly expressed in brain, spinal cord, testis, and white adipose tissue. In situ hybridization studies revealed an extensive hybridization pattern in the central nervous system, with high levels in cerebral cortex, hippocampus, cerebellum, thalamus, brainstem, and spinal cord. The cloned A1-adenosine receptor may thus mediate many of the modulatory actions of adenosine in neural and endocrine systems.
2-Aminopyrimidine Directed Self-Assembly of Zinc Porphyrins Containing Bulky 3,5-Di-tert-butylphenyl Groups (2003)

The 2-aminopyrimidin-5-yl ligand is revealed to be a promising candidate for the construction of supramolecular porphyrin arrays with broad absorption bands for efficient light-harvesting. 10-Mono- and 10,20-di(2-aminopyrimidin-5-yl) derivatives of 5,15-bis(3,5-di-tert-butylphenyl)porphyrin have been synthesized in high yield. Their Zn(II) salts show variable concentration and temperature-dependent UV/vis spectra in solution, consistent with supramolecular aggregation. Whereas the FAB mass spectra of the monosubsituted derivative in toluene suggest the formation of a tetramer at high concentrations and low temperatures (estimated association free enthalpy Delta H = 220 +/- 10 kJ/mol), the larger splitting of the Sorret band (ca. 40 nm) in the variable temperature UV/vis spectra of the disubstituted bis(3,5-di-tert-butylphenyl)porphyrin is indicative of yet higher aggregates involving both 2-aminopyrimidin-5-yl groups. The tetrameric nature of the monosubsituted derivative is confirmed by X-ray analysis, which reveals that two of the 2-aminopyrimidin-5-yl groups are encapsulated by the aggregate and consequently are prevented from undergoing hydrogen bonding. NMR studies show there is no exchange of the 2-aminopyrimidin-5-yl groups, so the tetramer is rigid, which is confirmed by molecular modeling calculations. The tetramer formation is governed by pi-pi interactions, metal coordination, and hydrogen bonding. The di(2-aminopyrimidin-5-yl) derivative forms strongly scattering solutions, which upon standing form green flocculate precipitates, reminiscent of shaken suspensions of bacteriochlorophyll c.
Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men (2014)

In older men, and in younger men with pre-existing diagnosed heart disease, the risk of MI following initiation of TT prescription is substantially increased.
Characterization and in vitro expression patterns of an exopolygalacturonase encoding gene from Fusarium oxysporum f.sp. radicis lycopersici (2003)

This study reports the analysis of a novel EXOPG gene of the tomato pathogen F. oxysporum f.sp. radicis lycopersici, a contribution to the understanding of the role of cell-wall-degrading enzymes produced by fungi during pathogenesis.
Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils. (1992)

Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. MCAF led to peak histamine release within 1 min. 80% of the subjects tested were responsive to MCAF or anti-IgE, while all were responsive to FMLP. The percentage histamine release by MCAF was, however, less than that seen with anti-IgE or FMLP, but this was attributable to a lesser percent release in nonatopic subjects; atopic subjects responded similarly to all three agonists. MCAF was also shown to activate highly purified human basophils more readily than mixed leukocytes, and its activity was inhibited by a polyclonal rabbit antibody. At a suboptimal concentration (2.5 x 10(-9) M), MCAF was unable to prime the basophil to histamine release by other secretagogues. However, interleukin 3 (IL-3) and IL-5 could each prime basophils for MCAF-induced secretion. Therefore, our results suggest that MCAF may be a major contributor to the histamine-releasing activity seen in peripheral blood mononuclear cell supernatants that has been designated histamine releasing factor(s).
MRC OX-2 defines a novel T cell costimulatory pathway (1997)

T cell activation requires the engagement of the TCR as well as a second, costimulatory signal. In this study, we demonstrate that MRC OX-2 (OX-2) mediates a previously unrecognized T cell costimulatory signal leading to enhanced T cell proliferation. One extensively studied costimulatory pathway, the B7/CD28 pathway, delivers its signal when CD28 is engaged by either of two ligands, B7-1 or B7-2, expressed on APC. Recent data have suggested that an additional ligand may exist in this pathway. This possibility prompted us to search previously cloned genes with both structural and expression characteristics similar to B7-1 and B7-2. Our search yielded OX-2, a rat lymphocyte activation marker, as a promising candidate gene. We now report that Chinese hamster ovary cell transfectants expressing the OX-2 protein can costimulate murine CD4+ T cells to proliferate in an Ag-independent fashion using anti-CD3, as well as an Ag-dependent fashion using peptide. In contrast to B7-1-mediated costimulation, OX-2 does not result in detectable levels of IL-2, IL-4, or IFN-gamma. In addition, OX-2 transfectants do not bind the soluble receptor reagents of the B7/CD28 pathway (CD28-Ig and CTLA4Ig). Furthermore, OX-2 costimulation is not inhibited by CTLA4Ig, as is B7-1-mediated costimulation, but is readily inhibited with an anti-OX-2 mAb. Thus, OX-2 is a T cell costimulatory ligand that acts through a non-B7/CD28 pathway, which leads to functionally distinct consequences, as reflected by the resulting cytokine profile.
Comunicación e imagen en las ONG (1999)

El presente articulo tiene la intencion de profundizar en el estudio sobre una de las herramientas principales del marketing con causa, que es la comunicacion, y que ademas de englobar numerosas actividades, tiene un peso especifico muy importante en la estrategia corporativa de toda organizacion. El estudio de los elementos de comunicacion interna y externa de las ONG puede darnos luz sobre hasta que punto las organizaciones sin animo de lucro se rigen en este ambito por los criterios de eficacia empresarial y transparencia que demanda la sociedad, u obedecen a otra logica alejada de las demandas del publico. Por este motivo, nos interesa describir y observar la relacion que se produce entre la estrategia de comunicacion aplicada a una determinada entidad y la imagen que proyecta sobre el conjunto social. Interesa observar y describir la relacion que hay entre la parte –la comunicacion– y el todo –la imagen global de la empresa–.
Th1/Th2 cytokine profiles in saliva of HIV‐positive smokers with oropharyngeal candidiasis (2002)

Oropharyngeal candidiasis (OPC) is a common opportunistic infection among HIV-positive individuals and often correlates with a CD4 cell number < 200 cells/microl. This study further examined the association of smoking and OPC in HIV-positive persons. A strong association between smoking and OPC was seen in HIV-positive individuals with > or =200 CD4 cells/microl. In HIV-positive persons with > or =200 CD4 cells/microl, OPC+ smokers had lower gamma-interferon (IFN-gamma) concentrations and a trend toward higher interleukin (IL)-4 concentrations in whole saliva compared to OPC- persons with > or =200 CD4 cells/microl, a cytokine profile consistent with that observed in HIV+OPC+ persons with < 200 CD4 cells/microl. These results suggest that premature OPC in HIV-positive smokers is associated with altered oral host defence mechanisms that cannot be overcome by levels of systemic CD4 cells that are otherwise sufficient to protect against OPC.
A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer (2011)

NET1 plays an important role in GC cell migration and invasion, key aspects of GC progression. Furthermore, the gene expression profile further elucidates the molecular mechanisms underpinning NET1-mediated aggressive GC cell behaviour.
IFN-α induces autoimmune T cells through the induction of intracellular adhesion molecule-1 and B7.2 (1996)

Insulin-dependent diabetes is an autoimmune disease characterized by the loss of the insulin-producing beta cells and the appearance of autoreactive (anti-islet) T cells. The mechanism by which these autoimmune T cells become activated has not been resolved. We demonstrate that the expression of IFN-alpha by the pancreatic beta cells leads to the development of CD4+ T cells that proliferate in the presence of islet Ags. These autoreactive T cells have a Th1 phenotype and are able to lyse islet cells, possibly through an indirect, cytokine-mediated mechanism. We also demonstrate that the pancreatic infiltrating leukocytes in the transgenic mice express increased levels of 87.2 and ICAM-1 and that IFN-alpha can directly induce these two costimulatory molecules on nontransgenic splenic APCs. Treatment of the transgenic mice with Abs against these costimulatory molecules demonstrated that B7.2 is essential for the induction of autoreactive T cells, whereas ICAM-1 contributes to but is not essential for the formation of these autoreactive cells. As B7.2 and ICAM-1 are able to synergize to provide costimulatory signals to naive T cells under conditions of limiting Ag, we propose that IFN-alpha expression normally contributes to the development of an anti-viral cellular immune response, but that uncontrolled expression of this cytokine will induce autoimmunity.
Patient monitoring using personal area networks of wireless intelligent sensors. (2001)

A wearable device for monitoring multiple physiological signals (polysomnograph) usually includes multiple wires connecting sensors and the monitoring device. In order to integrate information from intelligent sensors, all devices must be connected to a Personal Area Network (PAN). This system organization is unsuitable for longer and continuous monitoring, particularly during the normal activity. For instance, monitoring of athletes and computer assisted rehabilitation commonly involve unwieldy wires to arms and legs that restrain normal activity. We propose a wireless PAN of intelligent sensors as a system architecture of choice, and present a new design of wireless personal area network with physiological sensors for medical applications. Intelligent wireless sensors perform data acquisition and limited processing. Individual sensors monitor specific physiological signals (such as EEG, ECG, GSR, etc.) and communicate with each other and the personal server. Personal server integrates information from different sensors and communicates with the rest of telemedical system as a standard mobile unit. We present our prototype implementation of Wireless Intelligent SEnsor (WISE) based on a very low power consumption microcontroller and a DSP-based personal server. In future we expect all components of WISE integrated in a single chip for use in a variety of new medical applications and sophisticated human computer interfaces. Existing growth of wireless infrastructure will allow a range of new telemedical applications that will significantly improve the quality of health care.
Purification and characterization of a recombinant murine interleukin‐6 (1992)

Murine interleukin-6 (IL-6), when expressed in Escherichia coli using the pUC9 vector, accumulated as insoluble aggregates or 'inclusion bodies'. After selective urea washing of the inclusion bodies, to remove extraneous proteins, murine IL-6 was solubilized with 8 M guanidine hydrochloride and then rapidly purified to homogeneity by gel-permeation chromatography followed by reversed-phase HPLC. It was demonstrated that complete disulfide bond formation in murine IL-6 occurred during the early urea washing/guanidine hydrochloride extraction steps, so no refolding step was required. When fully reduced murine IL-6 was dissolved in 8 M guanidine hydrochloride and allowed to air-oxidize, complete disulfide bond formation, monitored by analytical reversed-phase HPLC, was shown to occur within 13 h at 6 degrees C. About 25 mg pure protein was obtained from 37 g wet cells. This recombinant murine IL-6 had a specific activity in the hybridoma growth factor assay of 2 x 10(8) U/mg, which is equivalent to that of native murine IL-6. During the purification procedure, a number of variant forms of murine IL-6 were isolated and partially characterized. Two of these forms, T1 and T3, were C-terminal deletants of murine IL-6 lacking about 60 and 20 amino acids from the C-terminus, respectively, while the other form, T2, was an N-terminal deletant lacking 37 amino acids from the N-terminus. None of these variant forms of murine IL-6 bound to the murine IL-6 receptor and, consequently, all were inactive in the hybridoma growth factor assay.
Modification of the Optoelectronic Properties of Membranes via Insertion of Amphiphilic Phenylenevinylene Oligoelectrolytes (2010)

We report on the modification of membranes by incorporation of phenylenevinylene oligoelectrolytes with the goal of tailoring their optical and electronic properties and their applications. A water-soluble distyrylstilbene oligoelectrolyte (DSSN+), capped at each end with nitrogen bound, terminally charged pendant groups, was synthesized. The photophysical and solvatochromatic properties of DSSN+ and the shorter distyrylbenzene analogue DSBN+ were probed and found to be useful for characterizing insertion into membranes based on phospholipid vesicle systems. A combination of UV/visible absorbance and photoluminescence spectroscopies, together with confocal microscopy, were employed to confirm membrane incorporation. Examination of the emission intensity profile in stationary multilamellar vesicles obtained with a polarized excitation source provides insight into the orientation of these chromophores within lipid bilayers and indicates that these molecules are highly ordered, such that the hydrophobic electronically delocalized region positions within the inner membrane with the long molecular axis perpendicular to the bilayer plane. Cyclic voltammetry experiments provide evidence that DSSN+ and DSBN+ facilitate transmembrane electron transport across lipid bilayers supported on glassy carbon electrodes. Additionally, the interaction with living microorganisms was probed. Fluorescence imaging indicates that DSSN+ and DSBN+ preferentially accumulate within cell membranes. Furthermore, notable increases in yeast microbial fuel cell performance were observed when employing DSSN+ as the electron transport mediator.
De geologische wordingsgeschiedenis van de Eifel (1987)

De oudste en tegelijk meest-algemene gesteenteformaties die we in de Eifel tegenkomen dateren uit het Devoon, een periode uit de geologische aardgeschiedenis die duurde van rond 395 tot 345 miljoen jaar geleden. Europa was gedurende deze periode verdeeld in een landgebied dat zich uitstrekte over het huidige noordelijk deel van Europa, terwijl Belgie en centraal Duitsland deel uitmaakten van de noordelijke kustzone van een zeegebied dat grote delen van het huidige zuidelijke Europa bedekte. Deze Devonische zee had een bodem die vanzelfsprekend bestond uit gesteenteformaties die voor de Devonische tijd waren gevormd. Om de geologische geschiedenis die zich voor het begin van het Devoon in het Eifelgebied en zijn omgeving heeft afgespeeld te kunnen begrijpen zullen we moeten bezien hoe de situatie zich in de loop van Cambrium, Ordovicium en Siluur heeft ontwikkeld.
Optimal vaccination schedules using simulated annealing (2008)

Software and additional data can be found at http://www.immunomics.eu/SA/
Ion Channel Probes for Scanning Ion Conductance Microscopy (2014)

The sensitivity and selectivity of ion channels provide an appealing opportunity for sensor development. Here, we describe ion channel probes (ICPs), which consist of multiple ion channels reconstituted into lipid bilayers suspended across the opening of perflourinated glass micropipets. When incorporated with a scanning ion conductance microscope (SICM), ICPs displayed a distance-dependent current response that depended on the number of ion channels in the membrane. With distance-dependent current as feedback, probes were translated laterally, to demonstrate the possibility of imaging with ICPs. The ICP platform yields several potential advantages for SICM that will enable exciting opportunities for incorporation of chemical information into imaging and for high-resolution imaging.
A 1Mb virtually SRAM (1986)

THE STORAGE CAPACITY OF STATIC RAMs has quadrupled every two years for three generations. The 1Mb SRAM development program has not been able to match this pace, because of lithographic limitations notwithstanding the increasing demand for larger capacity SRAMs. This paper will offer a Virtually Static RAM(VSRAM) employing dynamic RAM cells, that virtually act as a static RAM in that no refresh operation is required by the user.
Cyclooxygenases and the Central Nervous System (1997)

Prostaglandins (PGs) were first described in the brain by Samuelsson over 30 years ago (Samuelsson, 1964). Since then a large number of studies have shown that PGs are formed in regions of the brain and spinal cord in response to a variety of stimuli. The recent identification of two forms of cyclooxygenase (COX; Kujubu et al., 1991; Xie et al., 1991; Smith and DeWitt, 1996), both of which are expressed in the brain, along with superior tools for mapping COX distribution, has spurred a resurgence of interest in the role of PGs in the central nervous system (CNS). In this review we will describe new data in this area, focusing on the distribution and potential role of the COX isoforms in brain function and disease.
Selective Copper Chemical Vapor Deposition Using Pd-Activated Organosilane Films (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Copper Chemical Vapor Deposition Using Pd-Activated Organosilane FilmsStephen J. Potochnik, Pehr E. Pehrsson, David S. Y. Hsu, and Jeffrey M. CalvertCite this: Langmuir 1995, 11, 6, 1841–1845Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://doi.org/10.1021/la00006a001Request reuse permissionsArticle Views249Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts