gebhart/patrepeval huggingface dataset:
Handbook of size exclusion chromatography and related techniques (2004)

Introduction to Size Exclusion Chromatography, Edward G. Malawer Semigrid Polymer Gels for Size Exclusion Chromatography, Elizabeth Meehan Modified Silica-Based Packing Materials for Size Exclusion Chromatography, Roy Eksteen and Kelli J. Pardue Molecular Weight-Sensitive Detectors for Size Exclusion Chromatography, Christian Jackson and Howard G. Barth Characterization of Copolymers by Size Exclusion Chromatography, Gregorio R. Meira and Jorge R. Vega Size Exclusion Chromatography ofPolyamides, Polyesters, and Fluoropolymers, Christian Dauwe Size Exclusion Chromatography of Natural and Synthetic Rubber, Terutake Homma and Michiko Tazaki Size Exclusion Chromatography of Asphalts Richard R. Davison, Charles J. Glover, Barry L. Burrand Jerry A. Bullin Size Exclusion Chromatography of Acrylamide Homopolymer and Copolymers, Fu-mei C. Lin Size Exclusion Chromatography of Polyvinal Alcohol and Polyvinal Acetate, Dennis J. Nagy Size Exclusion Chromatography of Vinyl PyrrolidoneHomopolymer and Copolymers, Chi-san Wu, James F. Curry, Edward G. Malawer and Laurence Senak Size Exclusion Chromatography of Cellulose and Cellulose Derivatives, Elizabeth Sj holm Molecular Mass and Size Distribution Measurement of Lignins, BoHortling, Eila Turunen and P ivi Kokkonen Contribution of Size Exclusion Chromatography to Starch Glucan Characterization, Anton Huber and Werner Praznik Size Exclusion Chromatography of Proteins, John O. Baker, W. S. Adney, M. Chen and Michael E.Himmel Size Exclusion Chromatography of Nucleic Acids, Yoshio Kato and Shigeru Nakatani Size Exclusion Chromatography of Low Molecular Wight Materials, Shyhchang Huang Two-Dimensional Liquid Chromatography of Synthetic Macromolecules, Susan Berek Methods and Columns for High-Speed Size Exclusion Chromatography Separations, Peter Kilz Automatic, Continuous Mixing Techniques for Online Monitoring of Polymer Reactions and for the Determination of Equilibrium Properties, Wayne F. Reed LightScattering and Solution Properties of Macromolecules, Philip J. Wyatt High Osmotic Pressure Chromatography, Iwao Teraoka and Dean Lee Size Exlcusion/Hydrodynamic Chromatography, Shychang Huang.
Vegetation Stress Detection through Chlorophyll a + b Estimation and Fluorescence Effects on Hyperspectral Imagery (2002)

Physical principles applied to remote sensing data are key to successfully quantifying vegetation physiological condition from the study of the light interaction with the canopy under observation. We used the fluorescence-reflectance-transmittance (FRT) and PROSPECT leaf models to simulate reflectance as a function of leaf biochemical and fluorescence variables. A series of laboratory measurements of spectral reflectance at leaf and canopy levels and a modeling study were conducted, demonstrating that effects of chlorophyll fluorescence (CF) can be detected by remote sensing. The coupled FRT and PROSPECT model enabled CF and chlorophyll a + b (Ca + b) content to be estimated by inversion. Laboratory measurements of leaf reflectance (r) and transmittance (t) from leaves with constant Ca + b allowed the study of CF effects on specific fluorescence-sensitive indices calculated in the Photosystem I (PS-I) and Photosystem II (PS-II) optical region, such as the curvature index [CUR; (R675.R690)/R2(683)]. Dark-adapted and steady-state fluorescence measurements, such as the ratio of variable to maximal fluorescence (Fv/Fm), steady state maximal fluorescence (F'm), steady state fluorescence (Ft), and the effective quantum yield (delta F/F'm) are accurately estimated by inverting the FRT-PROSPECT model. A double peak in the derivative reflectance (DR) was related to increased CF and Ca + b concentration. These results were consistent with imagery collected with a compact airborne spectrographic imager (CASI) sensor from sites of sugar maple (Acer saccharum Marshall) of high and low stress conditions, showing a double peak on canopy derivative reflectance in the red-edge spectral region. We developed a derivative chlorophyll index (DCI; calculated as D705/D722), a function of the combined effects of CF and Ca + b content, and used it to detect vegetation stress.
Characterization of late and early hematopoietic progenitor/stem cell sensitivity to mafosfamide. (1995)

The preservation of the hematopoietic value of the graft is essential in the context of bone marrow purging for autologous transplantation. In the present study we have investigated mafosfamide toxicity to transplantable hematopoietic stem cells using combinations of recombinant growth factors (GF) in semi-solid assays and by measurement of Long-Term Culture Initiating Cells (LTC-IC). Our data show that various subtypes of progenitor/stem cells were inhibited in a dose-dependent manner by mafosfamide. A hierarchy appeared clearly regarding sensitivity to the drug in the following order of increasing resistance: PCM CFU-GM (grown in presence of placenta-conditioned medium), 4R CFU-GM (grown in presence of GM-CSF + IL-3 + G-CSF + EPO), 5R CFU-GM (grown in presence GM-CSF + IL-3 + G-CSF + EPO + SCF) and LTC-IC with respective lethal dose 95 (LD95) levels of 40 micrograms, 55 micrograms, 90 micrograms and 140 micrograms/10(7) MNC (P = 0.05 to P = 0.018). Even the primitive stem cells treated with very high doses of mafosfamide (2 to 4 times the usually recommended dose) responded to a combination of SCF + GM-CSF + G-CSF + IL-3 in liquid marrow culture, suggesting that they were functionally spared by the treatment. We also observed a higher sensitivity of 5R CFU-GM and LTC-IC from patients with hematological malignancies, compared with normal donors, when marrow was treated with the dose chosen for clinical purging.(ABSTRACT TRUNCATED AT 250 WORDS)
Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states (2003)

The mechanisms by which S-nitrosohemoglobin (SNOHb) stimulates vasodilation are unclear and underlie the controversies surrounding the proposal that this S-nitrosothiol modulates blood flow in vivo. Among the mechanistic complexities are the nature of vasoactive species released from SNOHb and the role heme and oxygen play in this process. This is important to address since hemoglobin inhibits NO-dependent vasodilation. We compared the vasodilatory properties of distinct oxidation and ligation states of SNOHb at different oxygen tensions. The results show that SNOHb in the oxygenated state (SNOoxyHb) is significantly less efficient than SNOHb in the ferric or met oxidation state (SNOmetHb) at stimulating relaxation of isolated rat aortic rings. Using pharmacologic approaches to modulate nitrogen monoxide radical (.NO)-dependent relaxation, our data suggest that SNOoxyHb promotes vasodilation in a.NO-independent manner. In contrast, both SNOmetHb and S-nitrosoglutathione (GSNO), a putative intermediate in SNOHb reactivity, elicit vasodilation in a.NO-dependent process. Consistent with previous observations, an increase in sensitivity of SNOHb vasodilation at low oxygen tensions also was observed. However, this was not exclusive for this protein but applied to a range of nitrosovasodilators (including a.NO donor [DeaNonoate], an S-nitrosothiol [GSNO], and the nitroxyl anion donor, Angelis salt). This suggests that oxygen-dependent modulation of SNOHb vasoactivity does not occur by controlling the allosteric state of Hb but is a property of vessel responsiveness to nitrosovasodilators at low oxygen tensions.
Dense Optical Flow Prediction from a Static Image (2015)

Given a scene, what is going to move, and in what direction will it move? Such a question could be considered a non-semantic form of action prediction. In this work, we present a convolutional neural network (CNN) based approach for motion prediction. Given a static image, this CNN predicts the future motion of each and every pixel in the image in terms of optical flow. Our CNN model leverages the data in tens of thousands of realistic videos to train our model. Our method relies on absolutely no human labeling and is able to predict motion based on the context of the scene. Because our CNN model makes no assumptions about the underlying scene, it can predict future optical flow on a diverse set of scenarios. We outperform all previous approaches by large margins.
Novel Immunotherapy for Malignant Melanoma with a Monoclonal Antibody That Blocks CEACAM1 Homophilic Interactions (2012)

CEACAM1 (biliary glycoprotein-1, CD66a) was reported as a strong clinical predictor of poor prognosis in melanoma. We have previously identified CEACAM1 as a tumor escape mechanism from cytotoxic lymphocytes. Here, we present substantial evidence in vitro and in vivo that blocking of CEACAM1 function with a novel monoclonal antibody (MRG1) is a promising strategy for cancer immunotherapy. MRG1, a murine IgG1 monoclonal antibody, was raised against human CEACAM1. It recognizes the CEACAM1-specific N-domain with high affinity (K(D) ~ 2 nmol/L). Furthermore, MRG1 is a potent inhibitor of CEACAM1 homophilic binding and does not induce any agonistic effect. We show using cytotoxicity assays that MRG1 renders multiple melanoma cell lines more vulnerable to T cells in a dose-dependent manner, only following antigen-restricted recognition. Accordingly, MRG1 significantly enhances the antitumor effect of adoptively transferred, melanoma-reactive human lymphocytes using human melanoma xenograft models in severe combined immunodeficient/nonobese diabetic (SCID/NOD) mice. A significant antibody-dependent cell cytotoxicity response was excluded. It is shown that MRG1 reaches the tumor and is cleared within a week. Importantly, approximately 90% of melanoma specimens are CEACAM1(+), implying that the majority of patients with melanoma could be amenable to MRG1-based therapy. Normal human tissue microarray displays limited binding to luminal epithelial cells on some secretory ducts, which was weaker than the broad normal cell binding of other anticancer antibodies in clinical use. Importantly, MRG1 does not directly affect CEACAM1(+) cells. CEACAM1 blockade is different from other immunomodulatory approaches, as MRG1 targets inhibitory interactions between tumor cells and late effector lymphocytes, which is thus a more specific and compartmentalized immune stimulation with potentially superior safety profile.
Bone Resorption Inhibitors from Hop Extract (1997)

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humu)one as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC so (concentration of 50% inhibition) value was 5.9 x 10-9 M.
Expression of Murine CD1 on Gastrointestinal Epithelium (1990)

Cluster of differentiation 1 (CD1) in humans is a family of major histocompatibility complex (MHC) class I-like molecules expressed on the surface of immature thymocytes, Langerhans cells, and a subpopulation of B cells. The only function identified for human CD1 is as a ligand recognized by a subpopulation of T lymphocytes. In order to study the distribution and function of these molecules in the mouse, a murine CD1 complementary DNA was expressed in mouse fibroblasts and used to produce monoclonal antibodies. These antibodies revealed prominent expression of murine CD1 only on gastrointestinal tract epithelium and in the cytoplasm of hepatocytes. Low levels of expression were also detected on thymocytes and peripheral lymphocytes. The gastrointestinal distribution of murine CD1 suggests that this molecule may be important in epithelial immunity.
Ester homologation revisited: a reliable, higher yielding and better understood procedure (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEster homologation revisited: a reliable, higher yielding and better understood procedureConrad J. Kowalski and Rajarathnam E. ReddyCite this: J. Org. Chem. 1992, 57, 26, 7194–7208Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jo00052a038https://doi.org/10.1021/jo00052a038research-articleACS PublicationsRequest reuse permissionsArticle Views1810Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Immunocytochemical Localization of Atrial Natriuretic Peptide, Vessel Dilator, Long-acting Natriuretic Peptide, and Kaliuretic Peptide in Human Pancreatic Adenocarcinomas (2005)

We recently found that four peptide hormones synthesized by the same gene completely inhibit the growth of human pancreatic adenocarcinomas in athymic mice. The present immunocytochemical investigation was designed to determine where in the adenocarcinomas these peptide hormones localize. Atrial natriuretic peptide, vessel dilator, long-acting natriuretic peptide, and kaliuretic peptide localized to the cytoplasm and nucleus of the human pancreatic adenocarcinomas, which is consistent with their ability to decrease DNA synthesis in the nucleus of this cancer. In this first investigation of where these peptide hormones with anticancer effects localize in any cancer, these peptide hormones also localized to the endothelium of capillaries and fibroblasts within these cancers. This is the first demonstration of growth-inhibiting peptide hormones localizing to the nucleus, where they inhibit DNA synthesis and may interact with growth-promoting hormones that localize there as the etiology of their ability to inhibit the growth of adenocarcinomas both in vitro and in vivo.
Atypical hemolytic uremic syndrome (2011)

Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae or other causes, aHUS designates a primary disease due to a disorder in complement alternative pathway regulation. Atypical HUS represents 5 -10% of HUS in children, but the majority of HUS in adults. The incidence of complement-aHUS is not known precisely. However, more than 1000 aHUS patients investigated for complement abnormalities have been reported. Onset is from the neonatal period to the adult age. Most patients present with hemolytic anemia, thrombocytopenia and renal failure and 20% have extra renal manifestations. Two to 10% die and one third progress to end-stage renal failure at first episode. Half of patients have relapses. Mutations in the genes encoding complement regulatory proteins factor H, membrane cofactor protein (MCP), factor I or thrombomodulin have been demonstrated in 20-30%, 5-15%, 4-10% and 3-5% of patients respectively, and mutations in the genes of C3 convertase proteins, C3 and factor B, in 2-10% and 1-4%. In addition, 6-10% of patients have anti-factor H antibodies. Diagnosis of aHUS relies on 1) No associated disease 2) No criteria for Shigatoxin-HUS (stool culture and PCR for Shiga-toxins; serology for anti-lipopolysaccharides antibodies) 3) No criteria for thrombotic thrombocytopenic purpura (serum ADAMTS 13 activity > 10%). Investigation of the complement system is required (C3, C4, factor H and factor I plasma concentration, MCP expression on leukocytes and anti-factor H antibodies; genetic screening to identify risk factors). The disease is familial in approximately 20% of pedigrees, with an autosomal recessive or dominant mode of transmission. As penetrance of the disease is 50%, genetic counseling is difficult. Plasmatherapy has been first line treatment until presently, without unquestionable demonstration of efficiency. There is a high risk of post-transplant recurrence, except in MCP-HUS. Case reports and two phase II trials show an impressive efficacy of the complement C5 blocker eculizumab, suggesting it will be the next standard of care. Except for patients treated by intensive plasmatherapy or eculizumab, the worst prognosis is in factor H-HUS, as mortality can reach 20% and 50% of survivors do not recover renal function. Half of factor I-HUS progress to end-stage renal failure. Conversely, most patients with MCP-HUS have preserved renal function. Anti-factor H antibodies-HUS has favourable outcome if treated early.
Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. (1978)

A human leukemic cell line (designated HL-60) has recently been established from the peripheral blood leukocytes of a patient with acute promyelocytic leukemia. This cell line displays distinct morphological and histochemical commitment towards myeloid differentiation. The cultured cells are predominantly promyelocytes, but the addition of dimethyl sulfoxide to the culture induces them to differentiate into myelocytes, metamyelocytes, and banded and segmented neutrophils. All 150 clones developed from the HL-60 culture show similar morphological differentiation in the presence of dimethyl sulfoxide. Unlike the morphologically immature promyelocytes, the dimethyl sulfoxide-induced mature cells exhibit functional maturity as exemplified by phagocytic activity. A number of other compounds previously shown to induce erythroid differentiation of mouse erythroleukemia (Friend) cells can induce analogous maturation of the myeloid HL-60 cells. The marked similarity in behavior of HL-60 cells and Friend cells in the presence of these inducing agents suggests that similar molecular mechanisms are involved in the induction of differentiation of these human myeloid and murine erythroid leukemic cells.
The Unusual Electrochemical and Photophysical Behavior of 2,2‘-Bis(1,3,4-oxadiazol-2-yl)biphenyls, Effective Electron Transport Hosts for Phosphorescent Organic Light Emitting Diodes (2006)

The fluorescence and phosphorescence of 2,2'-bis(5-phenyl-1,3,4-oxadiazol-2-yl)biphenyl shows good spectral matching with the absorption spectra of the MLCT1 and MLCT3 transitions of Ir(ppy)3. The red-shift of the 0-0 band in the phosphorescence at 77 K is due to the intramolecular pi-pi interactions between the oxadiazole side chains. Maximum brightness of 43,000 cd/m2 with an efficiency of 26 cd/A at 200 cd/m2 was achieved when BOBP was used as the host material for Ir(ppy)3 in the PHOLED study. [structure: see text].
Face swapping (2008)

In this paper, we present a complete system for automatic face replacement in images. Our system uses a large library of face images created automatically by downloading images from the internet, extracting faces using face detection software, and aligning each extracted face to a common coordinate system. This library is constructed off-line, once, and can be efficiently accessed during face replacement. Our replacement algorithm has three main stages. First, given an input image, we detect all faces that are present, align them to the coordinate system used by our face library, and select candidate face images from our face library that are similar to the input face in appearance and pose. Second, we adjust the pose, lighting, and color of the candidate face images to match the appearance of those in the input image, and seamlessly blend in the results. Third, we rank the blended candidate replacements by computing a match distance over the overlap region. Our approach requires no 3D model, is fully automatic, and generates highly plausible results across a wide range of skin tones, lighting conditions, and viewpoints. We show how our approach can be used for a variety of applications including face de-identification and the creation of appealing group photographs from a set of images. We conclude with a user study that validates the high quality of our replacement results, and a discussion on the current limitations of our system.
Direct Evidence That Perhexiline Modifies Myocardial Substrate Utilization from Fatty Acids to Lactate (1995)

Perhexiline maleate, originally classified as a calcium antagonist, is in use as an antianginal agent. The mechanism of its protective effect is unknown, but there is speculation that it involves a modification of myocardial substrate utilization, in which glycolytic sources are used rather than fatty acids. This hypothesis was tested by employing [13C]NMR isotopomer analysis to measure substrate selection in the working rat heart. Substrate utilization was measured from a mixture of substrates present at their physiological concentration, as follows: acetoacetate, glucose, lactate and long-chain fatty acids. Control perfusions were compared with those perfused with perhexiline. It was found that perhexiline increased lactate utilization, which reduced the extent of fatty acid and endogenous substrate oxidation. There was also a significant increase in cardiac output for a small and insignificant increase in oxygen consumption, which suggested an improvement in myocardial efficiency. Thus, it was confirmed by direct measurement that this drug does modify substrate oxidation, which suggests that further investigations of the role that this agent can play in the management of ischemic heart disease would be beneficial.
Calibratable adaptive antenna combiner at 5.2 GHz with high yield for laptop interface card (2000)

This paper presents a calibratable adaptive antenna combiner with three branches for high-performance radio local area network at 5.2 GHz. The system was mounted on a reinforced duroid substrate and enables the integration in a laptop interface card. Each branch consists of a bent stacked slot antenna, a low-noise-amplifier monolithic microwave integrated circuit (MMIC) with antenna/calibration switching and a vector modulator MMIC with an amplitude control range of 15 dB and 3600 phase control range. The signals of the three branches are combined by an active adder MMIC. A calibration is proposed to significantly improve the phase and amplitude control resolution and the yield of the designed MMIC circuits, which were fabricated using a commercial GaAs process. Each branch has a maximum power gain of 16 dB, a noise figure of 3.3 dB, and a 1-dB output compression point of -4 dBm. The whole system draws less than 28 mA from a 2.7-V voltage supply. The total required MMIC chip size is 10.8 mm/sup 2/.
Limnology in the northeastern tropics of Australia, the wettest part of the driest continent (1994)

Until recently, research work dealing with the inland waters of northern Australia was neglected. The current increase in environmental awareness has provided a stimulus for research on the fresh w...