gebhart/patrepeval huggingface dataset:
THE EFFECT OF MOXIBUSTION ON IMMUNITY IN RATS (1992)

Our previous works have proved that moxibustion at“Shenque(RN8)”playa role in protecting gastric mucosa in experimental gastric ulcer modal rats.The present studieswere designed to determine whether moxibustion affects immunity.The results showed that theactivity of bacteriolysin.the antibody forming cell.of the spleen,the titer of anti.SRBC antibodyand the transformation of lymphocytes were all significantly increased in moxibustion groups.andthe course of moxibustion must be longer than 14 days.The results suggested that moxibustioncould stimulate immunity in rats(including non-specific and specific immunity.cellular andhumoral immunity)and the course of moxibustion should not be less than two weeks.
Culture and Characterization of Human Bone Marrow Mesenchymal Stem Cells (2007)

Bone marrow (BM) mesenchymal stem cells (MSCs) are non-hematopoietic cells capable of generating colonies of plastic-adherent marrow mesenchymal cells, each derived from a single cell termed a colony-forming unit fibroblasts (CFU-Fs). In addition to their role in establishing the marrow microenvironment, these cells have been shown to differentiate into several types of mesenchymal and non-mesenchymal lineages. Because of their multipotency, MSCs represent an attractive cellular source in the promising field of cellular therapy. In this chapter, we will focus on culture conditions for human BM MSC expansion and CFU-F assays. We also describe the methodologies to analyze the primary cultures obtained, both at the phenotypic and at the functional levels. Phenotypically, MSCs can be defined with a minimal set of markers as CD31-, CD34-, and CD45-negative cells and CD13-, CD29-, CD73-, CD90-, CD105-, and CD166-positive cells. Functionally, we describe the culture conditions (specific media and cellular preparations) for in vitro differentiation of MSCs into the adipogenic, osteogenic, and chondrogenic lineages. The corresponding colorimetric assays (oil red O, Von Kossa and alizarin red S, and safranin O and alcian blue stains, respectively) are also described.
New geometric isomers of vitamin A and carotenoids. 6. Fluorinated rhodopsin analogs from 10-fluoro- and 14-fluororetinal (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew geometric isomers of vitamin A and carotenoids. 6. Fluorinated rhodopsin analogs from 10-fluoro- and 14-fluororetinalAlfred E. Asato, Hiroyuki Matsumoto, Marlene Denny, and R. S. H. LiuCite this: J. Am. Chem. Soc. 1978, 100, 18, 5957–5960Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00486a066https://doi.org/10.1021/ja00486a066research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate (2003)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate†Stephen W. RagsdaleView Author Information Department of Biochemistry, Beadle Center, 19th and Vine Streets, University of Nebraska, Lincoln, Nebraska 68588-0664 Cite this: Chem. Rev. 2003, 103, 6, 2333–2346Publication Date (Web):April 8, 2003Publication History Received8 August 2002Published online8 April 2003Published inissue 1 June 2003https://doi.org/10.1021/cr020423eCopyright © 2003 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3266Altmetric-Citations176LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (995 KB) Get e-AlertsSUBJECTS:Anions,Charge transfer,Cluster chemistry,Peptides and proteins,Transfer reactions Get e-Alerts
Epidermal Growth Factor Receptor Copy Number Alterations Correlate With Poor Clinical Outcome in Patients With Head and Neck Squamous Cancer (2007)

A subset of HNSCC manifests EGFR copy number alterations, and this is associated with a poor clinical outcome, suggesting a biologic role of the alterations. The rare mutation or small deletion at EGFR exons 18 to 21 indicates a minimal role of these events in HNSCC.
Tumor-Targeted Drug Delivery and MRI Contrast Enhancement by Chlorotoxin-Conjugated Iron Oxide Nanoparticles (2008)

The improved specificity, extended particle retention and increased cytotoxicity toward tumor cells demonstrated by this multifunctional nanoparticle system suggest that it possesses potential for applications in cancer diagnosis and treatment.
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling (2012)

COPD is a disease of innate immunity and bacterial infections are a dominant cause of exacerbations in the later stages resulting in poor health and high mortality. The pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) is sensed by immune cells through activation of the toll-like receptor 4 (TLR4). This leads to the activation of NADPH oxidase (NOX) and NF-κB which together drive COPD inflammation. In this study we show in human PBMCs that LPS stimulated proinflammatory cytokine release (CXCL8 and IL6) was inhibited by approximately 50% by the broad specificity phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin. Our results also demonstrate that activation of PI3K following LPS stimulation is mediated by a NOX4 dependent mechanism releasing endogenous H2O2, as the NOX4 inhibitor apocynin blocked LPS induced AKT phosphorylation. Moreover, LPS-induced PI3K activation was inhibited by the anti-oxidant N-acetylcysteine in a concentration dependent manner (IC50 ~100 μM). In addition, our data demonstrated that inhibition of small G proteins, by pre-treatment with pertussis toxin, inhibited LPS-induced AKT phosphorylation. Furthermore, the G-protein inhibitors pertussis toxin and mastoparan both inhibited LPS-induced CXCL8 and IL-6 release by approximately 50%. Together, these data indicate there is a mechanism in human PBMCs where TLR4 activation by LPS leads to ROS generation through NOX4 and activation of the PI3K pathway. This effect is apparently mediated through small G proteins facilitating the release of pro-inflammatory cytokines.
Vapor Pressure of Explosives: A Critical Review (2012)

Abstract A critical review of vapor pressure data for military, civilian, and homemade explosives, explosive precursors, and explosive taggants is presented. It gives reference to a large number of papers and reports presenting original vapor pressure measurements and additionally an overview of measurements techniques for vapor pressure measurements and data analysis of vapor pressure measurements. Vapor pressure data, including Clausius–Clapeyron parameters ( A and B in: log10( p )= A−B / T ), calculated vapor pressure at room temperature, and heat of sublimation or heat of vaporization are included. The following classes of compounds are treated; military explosives (TNT, RDX, HMX, PETN, HNS, TATB, AP), civilian explosives (NG, EGDN, AN), explosive taggants (EGDN, DNMB, 2‐NT, 4‐NT), home‐made explosives (TATP, DADP, HMTD). and explosive precursors [HP( aq ), NM, IPN, DNT].
Optical path cross-connect systems for photonic transport networks (2002)

Optical path layer technologies will play a key role in the development of the platform on which future bandwidth abandoned B-ISDN should be created. The paper highlights the wavelength path (WP) and the virtual wavelength path (VWP) techniques, both of which can greatly enhance the path layer capability and the efficiency of network failure restoration. The WP and VWP schemes are compared focusing on network restoration performance. It is demonstrated that the VWP scheme can reduce the required number of wavelengths needed for network restoration, Optical cross-connect node architectures for both schemes are then examined. Cross-connect systems which utilise optical regeneration are shown to be effective, and system architectures are revealed to be basically identical. The authors propose two types of cross-connect switch architectures using space division switches and combinations of star-couplers and multi-wavelength selective filters (MWSFs). The hardware requirements are quantitatively evaluated. It is shown that when the port number is larger than 16, the amount of hardware required to support the VWPs ranges from two to three times that required for the WPs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
40.1: Invited Paper : Scrolling Color LCOS for HDTV Rear Projection (2001)

Abstract We report on advancements for a single‐panel Liquid Crystal On Silicon (LCOS) display based on the Philips scrolling‐color architecture. Performance and cost advantages make this system ideal for High Definition Television (HDTV). We discuss aspects of a 64″ rear projection display showing a 1280×720 image.
The Preparation of Hydroxyphenylserines from Benzyloxybenzaldehydes and Glycine1 (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Hydroxyphenylserines from Benzyloxybenzaldehydes and Glycine1William A. BolhoferCite this: J. Am. Chem. Soc. 1954, 76, 5, 1322–1326Publication Date (Print):March 1, 1954Publication History Published online1 May 2002Published inissue 1 March 1954https://pubs.acs.org/doi/10.1021/ja01634a039https://doi.org/10.1021/ja01634a039research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vasopressin, levosimendan, and cardiovascular function in septic shock* (2010)

Critical Care Medicine; St. Paul's Hospital and University of British Columbia; Vancouver, BC, Canada Financial support was received from Canadian Institutes of Health Research (grant number MCT 44152, registration ISRCTN94845869). Dr. Russell reports holding stock in Sirius Genomics, which has submitted patents owned by the University of British Columbia and licensed to Sirius Genomics that are related to the genetics of vasopressin and protein C. The University of British Columbia has also submitted a patent related to the use of vasopressin in septic shock. Dr. Russell reports being an inventor of these patents. Dr. Russell also reports receiving consulting fees from Ferring, which manufactures vasopressin, and from Sirius Genomics. Dr. Russell reports receiving grant support from Sirius Genomics, Novartis, Ferring, and Eli Lilly. Dr. Russell has received speaking honoraria from Pfizer and Eli Lilly. Dr. Russell reports receiving consulting fees from Astra Zeneca, which manufactures anti-tumor necrosis factor.
Benign and Malignant Breast Disease: Initial Study Results of Serum and Breast Fluid Analyses of Endogenous Estrogens<xref ref-type="fn" rid="FN2">2</xref> (1987)

Design, methods, and study population of a long-term multidisciplinary investigation of benign and malignant breast disease were reported. This initial report focused on the relation of menstrual, reproductive, and other factors to serum and breast fluid estrogen measures [estradiol (E2), estrone (E1), percent free estrogen, and sex hormone binding globulin] among control women. After adjustment for the factors found to be related to the various estrogen measures, estrogen levels in women with benign and malignant disease were compared to those of controls. Findings were as follows: a) little evidence of any relation of most breast cancer risk factors with the various serum estrogen parameters studied; b) differences in breast fluid estrogen levels that may be relevant to the protective effect of parity on breast cancer risk; c) markedly higher levels of E2 and E1 in breast fluid than in serum and no evidence of a correlation of serum with breast fluid measures; d) no support for the hypothesis that breast cancer patients have higher serum percent free E2 than controls or women with benign breast disease; and e) higher breast fluid E2 and E1 levels in women with biopsied benign breast disease than in controls.
The Protein Core of the Proteoglycan Perlecan Binds Specifically to Fibroblast Growth Factor-7 (2000)

Perlecan is a multifaceted heparan sulfate proteoglycan that is expressed not only as an intrinsic constituent of basement membranes but also as a cell-surface and pericellular proteoglycan. Perlecan functions as a ligand reservoir for various growth factors that become stabilized against misfolding or proteolysis and acts as a co-receptor for basic fibroblast growth factor by augmenting high affinity binding and receptor activation. These biological properties are mediated by the heparan sulfate moiety. Rather little is known about the protein core's mediation of functions. We have recently discovered that fibroblast growth factor-7 (FGF7) binds to perlecan protein core and that exogenous perlecan efficiently reconstitutes FGF7 mitogenic activity in perlecan-deficient cells. In this report we examined the specific binding of FGF7 to various domains and subdomains of perlecan protein core. Using several experimental approaches including overlay protein assays, radioligand binding experiments, and the yeast two-hybrid system, we demonstrate that FGF7 binds specifically to the N-terminal half of domain III and to a lesser extent to domain V, with affinity constants in the range of 60 nM. Thus, perlecan protein core should be considered a novel biological ligand for FGF7, an interaction that could influence cancer growth and tissue remodeling.
Extracellular matrix in cutaneous ageing: the effects of 0.1% copper–zinc malonate‐containing cream on elastin biosynthesis (2008)

Cutaneous ageing, as visualized at the exposed areas of skin, reflects dramatic alterations in the structure and function of the extracellular matrix of connective tissues. Among them, the elastic fibre network, which is responsible for the physiological elasticity and resilience of normal skin, undergoes degradative changes leading to loss of functional elastic fibres. A potential strategy to counteract these degenerative changes entails topical application of a compound that may lead to regeneration of the elastic fibre network. In this study, we have evaluated the effects of a bi-metal, 0.1% copper-zinc malonate-containing cream that has been shown to efface wrinkles in clinical trials. An effect on elastin biosynthesis and elastic tissue accumulation in skin biopsies was observed in 21 female patients with photoaged facial skin, as measured at baseline and at 6 weeks of treatment. Histopathological evaluation revealed evidence of elastic fibre regeneration, including those extending perpendicularly towards the dermo-epidermal junction within the papillary dermis. Elastin biosynthesis, measured by semi-quantitative immunofluorescence with an antibody recognizing only the newly synthesized, uncrosslinked tropoelastin molecules, suggested statistically significant enhancement of elastin biosynthesis by the bi-metal compound when applied twice daily. Accumulation of elastic fibres was confirmed by assay of desmosine, an elastin-specific crosslink compound. These results suggest that the bi-metal, 0.1% copper-zinc malonate-containing cream has the propensity to increase elastin synthesis in human skin in vivo, and that regeneration of elastic fibres may contribute to wrinkle effacement in female patients with photoaged facial skin.
Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents (2019)

Antibody-oligonucleotide conjugates (AOCs) are a novel class of synthetic chimeric biomolecules that has been continually gaining traction in different fields of modern biotechnology. This is mainly due to the unique combination of the properties of their two constituents, exceptional targeting abilities and antibody biodistribution profiles, in addition to an extensive scope of oligonucleotide functional and structural roles. Combining these two classes of biomolecules in one chimeric construct has therefore become an important milestone in the development of numerous biotechnological applications, including imaging (DNA-PAINT), detection (PLA, PEA), and therapeutics (targeted siRNA/antisense delivery). Numerous synthetic approaches have been developed to access AOCs ranging from stochastic chemical bioconjugation to site-specific conjugation with reactive handles, introduced into antibody sequences through protein engineering. This Review gives a general overview of the current status of AOC applications with a specific emphasis on the synthetic methods used for their preparation. The reported synthetic techniques are discussed in terms of their practical aspects and limitations. The importance of the development of novel methods for the facile generation of AOCs possessing a defined constitution is highlighted as a priority in AOC research to ensure the advance of their new applications.
Distinctive Developmental Origins and Specificities of Murine CD5+ B Cells (1994)

CD5+ B cells constitute a small fraction of cells in the spleen of adult mice that exhibit numerous features serving to distinguish them from the bulk of IgD++CD5- "conventional" B cells. In this review we focus on two major questions relating to this population: 1) the relationship of CD5+ B cells to other B cells; and 2) the distinctive enrichment of particular autoreactive specificities in this subset. The nature of their origins is clarified by a thorough analysis of intermediate stages of early B-cell development in both fetal and adult tissues. The reactivity to bromelain-treated mouse red blood cells serves as a prototype system for the investigation of biased specificities in CD5+ B cells. These lines of investigation lead us to propose that CD5+ B cells in the adult are the remnant of a distinct fetal B-cell differentiation pathway wherein selection of cells from this fetal/neonatal population into the adult long-lived pool results in the over-expression of certain germline-encoded autoreactivities.
Comparison of replication-selective, oncolytic viruses for the treatment of human cancers. (2003)

During the last century, many attempts have been made to explore the cytotoxic effects of several wild-type viruses as oncolytic agents. Until recently, attenuated and replication-defective viruses have been used as vectors for cancer gene therapy for safety purposes. To enhance potency, both approaches have been combined by 'arming' these viruses with therapeutic transgenes. In order to enhance the therapeutic index, several strategies have been evaluated to generate tumor-selective oncolytic viruses, including the use of tumor-specific promoters which transcriptionally target viral genes pivotal for replication, or by deletion of viral functions dispensable for propagation in tumor cells but essential for productive infection of normal cells. In addition, retargeting of the adenoviral tropism towards tumors by capsid or envelope modifications has been evaluated. Controlled clinical trials with an oncolytic adenovirus in combination with chemotherapy have shown encouraging antineoplastic activity. For future vector developments, it will be crucial to achieve maximum vector distribution and transgene expression within tumors, to trigger a specific systemic immune effector response against treated and untreated lesions, and to modulate the immune system to avoid immune-mediated inactivation or destruction of the virus. In the context of replication-competent vectors without approved antiviral agents, suicide genes may be used as a fail-safe mechanism in the case of a runaway infection. Here, the most commonly used oncolytic viruses are reviewed with focus on their unique biological properties as well as the status of several of these mutants in clinical trials.
Exploring the Importance of Social Networks in the IT Workforce: Experiences with the "Boy's Club". (2004)

Currently, the information technology (IT) workforce is composed largely of males, while women remain an under represented minority. Not unlike other sectors, informal social networks exist which are often termed the “Old Boy’s Network.” In these networks, men are able to share information in a less formal setting, learn to trust each other, and establish personal relationships. However, these networks can be potentially problematic for women working in the field if they are excluded from important information and resources. This paper explores how women are affected by and relate to these networks. A conceptual framework is presented that explains the reactions and strategies with respect to the network that women employ for continued participation in the information technology workforce. The framework illustrates the experiences of proactive and reactive “insiders” and “outsiders” to the network.
Plasma Magnesium in Chronic Schizophrenia (1979)

A group of 36 subjects, 20 chronic schizophrenic patients and 16 nonpsychotic mentally retarded patients were chosen at random from the chronic care wards of the Douglas Hospital to assess levels of magnesium, calcium and phosphorus. No significant differences were found between the two groups in calcium and phosphorus. However, the magnesium level was significantly lower (p less than 0.01) in the schizophrenic group than in the mentally retarded group. This difference reached a level of 0.001 significance when chronic female schizophrenic patients were compared to the female mentally retarded group. Hospitalization, diet and medication were excluded as possible etiological factors.