gebhart/patrepeval huggingface dataset:
Polyether-Modified Poly(acrylic acid):  Synthesis and Applications (1998)

Poly(acrylic acid) (PAA) copolymers modified with block-copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) are inherently attractive for medicinal applications as their components are considered pharmaceutically safe. The laboratory-scale synthesis of poly(acrylic acid) bonded onto a PEO−PPO−PEO triblock (Pluronic) backbone via dispersion polymerization is reported. Initial optimization of the synthesis defines appropriate levels of initial loading of acrylic acid and Pluronic, with a mixture of 2,2‘-azobis(2,4-dimethylpentanenitrile) and lauroyl peroxide as an initiator system. The synthesis results in a copolymer with low residual monomer content and a very high degree of bonding between Pluronic and PAA. Diluted aqueous solutions of Pluronic-g-PAA exhibit rapid thermogelation. Rheological parameters of the copolymers urge on their ophthalmic applications.
Osmium(III)-Osmium(II) Electrode Potentials. The Effects of Charge, Conjugation, Coordinated Halide, and Substitution in the Ligand (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOsmium(III)-Osmium(II) Electrode Potentials. The Effects of Charge, Conjugation, Coordinated Halide, and Substitution in the LigandDavid A. Buckingham, Francis P. Dwyer, and Alan M. SargesonCite this: Inorg. Chem. 1966, 5, 7, 1243–1249Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://pubs.acs.org/doi/10.1021/ic50041a037https://doi.org/10.1021/ic50041a037research-articleACS PublicationsRequest reuse permissionsArticle Views297Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR+head and neck cancer cells (2013)

Toll-like receptor 3 (TLR3) agonists have been extensively used as adjuvants for anticancer vaccines. However, their immunostimulatory effects and precise mechanisms of action in the presence of antineoplastic monoclonal antibodies (mAbs) have not yet been evaluated. We investigated the effect of TLR3 agonists on cetuximab-mediated antibody-dependent cellular cytotoxicity (ADCC) against head and neck cancer (HNC) cells, as well as on dendritic cell (DC) maturation and cross-priming of epidermal growth factor receptor (EGFR)-specific CD8<sup>+</sup> T cells. The cytotoxic activity of peripheral blood mononuclear cells (PBMCs) or isolated natural killer (NK) cells expressing polymorphic variants (at codon 158) of the Fcγ receptor IIIa (FcγIIIa) was determined in <sup>51</sup>Cr release assays upon incubation with the TLR3 agonist poly-ICLC. NK cell stimulation was measured based on activation and degranulation markers, while DC maturation in the presence of poly-ICLC was assessed using flow cytometry. The DC-mediated cross priming of EGFR-specific CD8<sup>+</sup> T cells was monitored upon in vitro stimulation with tetramer-based flow cytometry. TLR3-stimulated, unfractionated PBMCs from HNC patients mediated robust cetuximab-dependent ADCC, which was abrogated by NK-cell depletion. The cytolytic activity of TLR3-stimulated NK cells differed among cells expressing different polymorphic variants of FcγRIIIa, and NK cells exposed to both poly-ICLC and cetuximab expressed higher levels of CD107a and granzyme B than their counterparts exposed to either stimulus alone. Poly-ICLC plus cetuximab also induced a robust upregulation of CD80, CD83 and CD86 on the surface of DCs, a process that was partially NK-cell dependent. Furthermore, DCs matured in these conditions exhibited improved cross-priming abilities, resulting in higher numbers of EGFR-specific CD8<sup>+</sup> T cells. These findings suggest that TLR3 agonists may provide a convenient means to improve the efficacy of mAb-based anticancer regimens.
Reducing dark current in a high-speed si-based interdigitated trench-electrode msm photodetector (2003)

The authors have studied higher dark-current temperature dependence in a trench-electrode Si-based metal-semiconductor-metal (MSM) photodetector which has a hydrogenated intrinsic amorphous silicon (i-a-Si:H) dark-current suppression layer. The poor dark-current temperature-dependence performance could be improved significantly by reducing the number of trap states in the depletion region of the reverse-biased crystalline/amorphous Si heterojunction. To reduce the trap states, a modified plasma-enhanced chemical vapor deposition (PECVD) system, which reduced the ion bombardment on the Si substrate, was employed to deposit an i-a-Si:H layer. Moreover, since fewer trap states in a photodetector will result in a degradation of the fall time of the temporal response of the device, a Ti electrode, which has a lower Schottky barrier height (0.62 eV) than that (0.84 eV) of the previous Cr electrode used with i-a-Si:H, was employed for compensation. The device obtained exhibited very good dark-current stability and temporal response. The dark current only increased from 6 to 34 nA, when the operating temperature was increased from room temperature (R. T.) to 57/spl deg/C, much lower than that of the previously reported 3-V bias voltage one (from 22 to 209 nA). Device responsivity and quantum efficiency also showed obvious improvement, both at R. T. (0.192 A/W and 0.29) and 57/spl deg/C (0.213 A/W and 0.32, respectively) and were higher than those previously reported (0.174 A/W and 0.26, at 57/spl deg/C).
Activation of the PI3 Kinase Pathway By Retinoic Acid Mediates Sodium/Iodide Symporter Induction and Iodide Transport in MCF-7 Breast Cancer Cells (2009)

Iodide uptake in the thyroid and breast is mediated by the sodium/iodide symporter (NIS). NIS activation is used for radioiodide imaging and therapeutic ablation of thyroid carcinoma. NIS is expressed in >70% of breast cancers but at a level insufficient for radioiodine treatment. All-trans retinoic acid (tRA) induces NIS gene expression and functional iodide uptake in human breast cancer cell lines and mouse breast cancer models. tRA usually regulates gene expression by direct interaction of RA receptor (RAR) with a target gene, but it can also act through nongenomic pathways. We report a direct influence of tRA treatment on the phosphoinositide 3-kinase (PI3K) signal transduction pathway that mediates tRA-induced NIS expression in MCF-7 breast cancer cells. MCF-7 cells express all three RAR isoforms, alpha, beta, and gamma, and RXRalpha. We previously identified RARbeta and RXRalpha as important for NIS induction by tRA. Treatment with LY294002, the PI3K inhibitor, or p85alpha knockdown with siRNA abolished tRA-induced NIS expression. Immunoprecipitation experiments and glutathione S-transferase pull-down assay showed a direct interaction between RARbeta2, RXRalpha, and p85alpha. RA also induced rapid activation of Akt in MCF-7 cells. Treatment with an Akt inhibitor or Akt knockdown with siRNA reduced NIS expression. These findings indicate that RA induction of NIS in MCF-7 cells is mediated by rapid activation of the PI3K pathway and involves direct interaction with RAR and retinoid X receptor. Defining these mechanisms should lead to methods to further enhance NIS expression, as well as retinoid targets that influence growth and differentiation of breast cancer.
The fatigue strength of porous‐coated Ti–6% Al–4% V implant alloy (1984)

The fatigue behaviour of Ti-6Al-4V (extra low interstital) alloy coated with Ti-6Al-4V powder was investigated using rotating bending fatigue testing. It was found that the high cycle fatigue strength of porous coated specimens exhibited a substantial decrease compared to uncoated specimens of the same microstructure. Chemical analysis of the sintered surface revealed significant increases of interstitials compared to the bulk analysis, but it is concluded that this would not adversely affect the fatigue strength. Scanning electron microscopy revealed crack initiation close to particle/substrate contact interfaces and it is concluded that stress intensification due to these interface regions are major sources of weakness with respect to fatigue strength. Finally it was found that subjecting a polished Ti-6Al-4V specimen to the heat treatment required for sintering resulted in delineation of prior beta grain boundaries and it is suggested that this also contributes to the inferior fatigue strength of porous coated Ti-6Al-4V.
Characterization of a Two-Transmon Processor with Individual Single-Shot Qubit Readout (2012)

We report the characterization of a two-qubit processor implemented with two capacitively coupled tunable superconducting qubits of the transmon type, each qubit having its own nondestructive single-shot readout. The fixed capacitive coupling yields the sqrt[iSWAP] two-qubit gate for a suitable interaction time. We reconstruct by state tomography the coherent dynamics of the two-bit register as a function of the interaction time, observe a violation of the Bell inequality by 22 standard deviations after correcting readout errors, and measure by quantum process tomography a gate fidelity of 90%.
Beam Shaping to Control of Weldpool Size in Width and Depth (2014)

The introduction of high power single mode fiber lasers has given deeper and narrower laser welds than seen previously. In some cases the weld becomes too narrow and must be expanded to fit the geometrical shape of a given weld task. It was suggested that instead of using only one beam, the beam was split into multiple beams placed in a pre-specified pattern. In this way the dimensions of the weld pool could be controlled. This gave the ability to control the final weld face width and penetrationdepth independently of each other with minimum heat input. Practical implementation of splitting a beam into a beam pattern with a diffractive optical element (DOE) is presented with results on splitting a beam from a single mode fiber laser into either three or seven individual beams on a row. Basic design rules for controlling the weld pool dimensions are developed. Results show that it is possible to control weldpool in size.
MATHEMATICAL ESTIMATION OF THE PENETRATION DEPTH OF ULTRASOUND AND ELECTROMAGNETIC FIELDS ENERGY (2004)

The authors present calculations on penetration of ultrasonic and electromagnetic fields in model space of the patient's body depending on the wave length and frequency of compressional waves emission.
Increased release of IL‐12p70 by monocytes after periodontal therapy (2003)

After periodontal therapy, the functional phenotype of the peripheral blood monocytes from patients was reconstituted, resembling that of subjects without periodontitis.
Gorilla (2015)

Large-scale internet services aim to remain highly available and responsive in the presence of unexpected failures. Providing this service often requires monitoring and analyzing tens of millions of measurements per second across a large number of systems, and one particularly effective solution is to store and query such measurements in a time series database (TSDB). A key challenge in the design of TSDBs is how to strike the right balance between efficiency, scalability, and reliability. In this paper we introduce Gorilla, Facebook's in-memory TSDB. Our insight is that users of monitoring systems do not place much emphasis on individual data points but rather on aggregate analysis, and recent data points are of much higher value than older points to quickly detect and diagnose the root cause of an ongoing problem. Gorilla optimizes for remaining highly available for writes and reads, even in the face of failures, at the expense of possibly dropping small amounts of data on the write path. To improve query efficiency, we aggressively leverage compression techniques such as delta-of-delta timestamps and XOR'd floating point values to reduce Gorilla's storage footprint by 10x. This allows us to store Gorilla's data in memory, reducing query latency by 73x and improving query throughput by 14x when compared to a traditional database (HBase)-backed time series data. This performance improvement has unlocked new monitoring and debugging tools, such as time series correlation search and more dense visualization tools. Gorilla also gracefully handles failures from a single-node to entire regions with little to no operational overhead.
Cyclosporin A Inhibits Early mRNA Expression of G0/G1 Switch Gene 2 ( G0S2 ) in Cultured Human Blood Mononuclear Cells (1997)

Cyclosporin A (CsA) may achieve its immunosuppressive effects by inhibiting the calcium- and calmodulin-dependent phosphatase calcineurin which is required for activation of target genes by members of the NFAT (nuclear factor of activated T cells) transcription factor family. Among these target genes is the gene encoding interleukin-2 (IL2), a cytokine facilitating progression through the G1 phase of the cell cycle. However, IL2 does not reverse CsA inhibition, suggesting that at least one other NFAT-sensitive gene may be involved. The human G0/G1 switch gene, G0S2, has potential NFAT-binding sites in the 5' flank and encodes a small basic potential phosphoprotein of unknown function. Using a sensitive, reverse transcription-polymerase chain reaction (RT-PCR) assay, G0S2 mRNA levels were assayed in cultured blood mononuclear cells. Freshly isolated cells contain high levels of G0S2 mRNA which rapidly decline. This "spontaneous stimulation" is also noted with some other G0S genes and has been attributed to some aspect of the isolation procedure. In cells that have been preincubated to lower mRNA levels, there is a transient increase in G0S2 mRNA, peaking between 1-2 h, in response to Concanavalin-A (ConA), or to the combination of phorbol ester (TPA), and the calcium ionophore, ionomycin. Both these responses are inhibited by CsA. Our results suggest that G0S2 expression is required to commit cells to enter the G1 phase of the cell cycle, and that, while not excluding other possible targets, early inhibition of G0S2 expression by CsA may be important in achieving immunosuppression. G0S2 may be of value as a reporter gene for analyzing the mechanism of action of CsA and its influence on the positive and negative selection of lymphocytes in response to self and not-self antigens.
The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. (1994)

The influence of apolipoprotein conformation on the ability of high density lipoprotein (HDL) to remove cellular free cholesterol (FC) has not been studied in detail. To address the effects of amphipathic alpha-helix structure on cellular FC efflux, three class A helical peptides and apolipoprotein (apo) AI were complexed to dimyristoyl phosphatidylcholine (DMPC) to make discoidal complexes that were used as acceptors of cell cholesterol. The peptides consisted of an 18-amino acid, amphipathic, alpha-helical peptide with the sequence DWLKAFYDKVAEKLKEAF (18A), a dimer of 18A covalently linked by a proline residue (37pA), and acetyl-18A-amide (Ac-18A-NH2) that has a higher alpha-helix content than the unblocked 18A molecule. The three peptides strongly mimic the lipid-binding characteristics of the amphipathic segments of apolipoproteins and form discoidal complexes with DMPC that are similar in diameter (11-12 nm) to those formed by human apoAI when reconstituted at a 2.5:1 (w:w) phospholipid to protein ratio. The abilities of these complexes to remove radiolabeled FC were compared in experiments using cultured mouse L-cell fibroblasts; efflux of FC from both the plasma membrane and the lysosomal pools was examined. For each of the acceptors, the removal of cholesterol from the plasma membrane and lysosomal pools was equally efficient. All four discoidal complexes were equally efficient cell membrane FC acceptors when compared at saturating acceptor concentrations of > 200 micrograms of DMPC/ml of medium. However, at the same lipid concentration, protein-free DMPC small unilamellar vesicles (SUV) were significantly less efficient. The initial rates of FC removal from cells at saturating concentrations of acceptor particles (Vmax) were 12, 10, 10, and 11% per h, respectively, for the complexes containing either 18A, Ac-18A-NH2, 37pA, or apoAI, but only 1% cellular FC per h for the DMPC SUV. The 10-fold higher Vmax for the apoprotein/peptide-containing acceptors was likely due to a reversible interaction of apoprotein or peptide with the plasma membrane that changed the lipid packing characteristics in such a way as to increase the rate of FC desorption from the cell surface. This interaction required amphipathic alpha-helical segments, but it was not affected by the length, number, or lipid-binding affinity of the helices. Furthermore, the efflux efficiency was not dependent on the amino acid sequence of the helical segments which suggests that this interaction is not mediated by a specific cell surface binding site.(ABSTRACT TRUNCATED AT 400 WORDS)
A Simple Autologous Fibrinogen Glue for Otologic Surgery (1986)

A simple method of concentrating a patient's own fibrinogen for use with a thrombin/calcium solution--to produce a coagulum-type tissue glue for otologic surgery--is presented. The principal advantages of this system include a simple modification of the cryoprecipitate technique, which can be easily performed in any hospital laboratory using a minimal amount of the patient's blood, and the use of autologous fibrinogen, which completely rules out the possibility of transmission of hepatitis or AIDS viruses. Useful tips on preparation and use of this autologous tissue glue, based on experience over the past 2 years, will be presented.
Abstract LB-374: The Hh inhibitor IPI-926 enhances tumor perfusion and nab-paclitaxel activity in a pancreatic xenograft model (2010)

Abstract Malignant activation of the Hedgehog (Hh) pathway is associated with multiple tumor types. In certain cancers, such as pancreatic, a paracrine role for the Hh ligand has been described, wherein cancer cells produce Hh ligand that activates the Hh pathway in the surrounding stroma. Consistent with this model, IPI-926, a potent and selective Smoothened (Smo) inhibitor, blocks Hh signaling in the mouse stroma -but not in the cancer cells- of several pancreatic xenograft models. We recently published (Olive, Science 2009) that IPI-926 increases vascular perfusion and enhances gemcitabine drug delivery to tumors in a genetically engineered mouse model of pancreatic cancer (KPC) leading to an increase in overall survival. To determine if similar effects could be observed in xenograft models of human pancreatic cancer, experiments were designed to study the combination of IPI-926 with nab-paclitaxel, an agent that has recently demonstrated anti-tumor activity in pancreatic cancer (Van Hoff, ASCO 2009). While IPI-926 had no single agent activity in the L3.6pl human pancreatic xenograft model, it enhanced the activity of nab-paclitaxel from 61% tumor growth inhibition (nab-paclitaxel alone) to 83% tumor growth inhibition (nab-paclitaxel plus IPI-926, p=0.0048). Tumor IHC analysis of phosphohistone 3 showed a higher frequency of cells arrested at the late G2/M phase in the IPI-926 plus nab-paclitaxel group versus nab-paclitaxel alone (p=0.02). One possible explanation for the synergistic effect of a combination of IPI-926 and nab-paclitaxel is that IPI-926 affects the mouse stroma and increases tumor perfusion and nab-paclitaxel accessibility to the tumor. Tumor perfusion was directly measured in IPI-926 treated and untreated animals using contrast enhanced ultrasound. In tumor bearing animals treated with IPI-926 for 7 days, the ultrasound data showed greater tumor perfusion with IPI-926. On average, the peak time for contrast agent levels decreased from 11.0 seconds to 4.75 seconds in the vehicle versus IPI-926 treated animals, respectively, (p=0.0321). These data suggest that the mechanism of synergy between IPI-926 and nab-paclitaxel is likely enhanced drug delivery to the tumor through the effect of IPI-926 on the stroma. Studies are ongoing to measure nab-paclitaxel and paclitaxel levels in IPI-926 treated and untreated tumors, and to investigate these findings with the KPC in situ mouse model of pancreatic cancer. These preclinical data provide a strong rationale for evaluating the Hh inhibitor IPI-926 not only with the current standard of care, gemcitabine, but with emerging new potential therapies like nab-paclitaxel in pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-374.
[Study on preparation and optical spectroscopy of nickel phthalocyanine-doped sol-gel materials]. (2004)

We report here the preparation of nickel tetrasulfo-phthalocyanine (NiTSPc)-doped silica xerogel matrix obtained by sol-gel technique. The evolution of silica matrix's texture and the rate during the sol-gel process, as well as silica xerogel's pore structure were studied. Dimerization behavior of NiTSPc molecules was characterized by electronic absorption spectra, and changes in the absorption spectra were correlated with various stages of the sol-gel process. The results show that in the composites NiTSPc concurs in the forms of monomer and dimer, and dimerization is stronger during the latter stages. The reason is given from the change in the micro-environment in which NiTSPc existed during the sol-gel process.