gebhart/patrepeval huggingface dataset:
Stimulation of 3-O-methylglucose transport in adipocytes by a synthetic human growth hormone fragment. (1985)

The insulin-like effects of intact human growth hormone (hGH) were demonstrated with a synthetic amino-terminal fragment of the molecule, containing the sequence Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala (hGH 6-13). The in vitro study on the molecular mechanism of the hypoglycaemic action revealed that hGH 6-13 enhanced the transport of 3-O-methylglucose in adipocytes independently of its ability to potentiate the binding of insulin to the isolated cells. Current results suggest that the hGH part-sequence either stimulated ligand-binding to intact cells, subsequently amplifying the membrane regulatory functions, or promoted a biochemical event common to the binding of insulin and concanavalin A, resulting in the increase of transport and utilization of glucose.
Assessing the Performance of Sub-Millimetre Compact Object Detection Algorithms (2010)

Sub-millimetre astronomy is about to be transformed by the deployment of new detectors that can map larger images than previously possible. A particular issue in sub-millimetre astronomy is the automated detection of compact, irregular regions of emission known as clumps. There are numerous clump detection software packages freely available yet there is little consensus as to which is the most appropriate to use, as each package has its own systematic bias when performing clumpfinding. The purpose of this investigation was to investigate a number of these clumpfinding packages and determine where some of these biases may lie. The CUPID package is designed for the creation and detection of clumps within images. There are four algorithms for the detection of clumps; ClumpFind, FellWalker, GaussClumps, and Reinhold. Each algorithm was individually investigated using data from SCAMPS (the SCUBA Massive Precluster Survey), (Thompson et al., 2005) to determine the effect of changing their parameters; the algorithms were then compared against each other to examine how the results differed between them. Using Monte Carlo simulations, Gaussian artificial clumps (with known peak, size, location, and integrated flux) were inserted into an image and the algorithms were tested to determine which algorithm extracted the information with the greatest accuracy, and where the completeness limits lie with each algorithm. ClumpFind, FellWalker, and Reinhold detected a lower integrated flux level than was inserted; this effect was more evident in large, flat clumps. Due to the profile of the clump it was expected that GaussClumps would detect the integrated flux more correctly, as was the proven case.
Effects of Egg White Protein Supplementation on Muscle Strength and Serum Free Amino Acid Concentrations (2012)

The aim of this study was to evaluate the effects of egg white protein compared to carbohydrate intake prior to exercise on fat free mass (FFM), one repetition maximum (1RM) muscle strength and blood biochemistry in female athletes. Thirty healthy female collegiate athletes were recruited for this study and matched by sport type, body fat percentage and 1RM leg curl muscle strength. Participants were randomly divided into two groups: protein group (15.0 g egg white protein; 75 kcal) and carbohydrate group (17.5 g maltodextrin, 78 kcal). Supplements were administered daily at the same time in a double-blind manner prior to training during an 8-week period. Measurements were performed before and after the 8-week regimen. The mean dietary energy intake did not change throughout the study period. FFM and 1RM assessments (i.e., leg curl, leg extension, squat, and bench press) increased in both groups. Furthermore, serum urea and serum citrulline levels after the 8-week regimen increased significantly only in the protein group. Our findings indicated that compared to the carbohydrate supplement, the protein supplement was associated with some changes in protein metabolites but not with changes in body composition or muscle strength.
Version models for software configuration management (1998)

After more than 20 years of research and practice in software configuration management (SCM), constructing consistent configurations of versioned software products still remains a challenge. This article focuses on the version models underlying both commercial systems and research prototypes. It provides an overview and classification of different versioning paradigms and defines and relates fundamental concepts such as revisions, variants, configurations, and changes. In particular, we focus on intensional versioning, that is, construction of versions based on configuration rules. Finally, we provide an overview of systems that have had significant impact on the development of the SCM discipline and classify them according to a detailed taxonomy.
Characteristics of adult patients with atrial septal defects presenting with paradoxical embolism (2009)

The incidence of adult patients with ASD who presented with paradoxical embolism is higher than expected and suggests that this diagnosis should be considered in patients with cryptogenic stroke.
연구논문(硏究論文) : 무대의상에 나타난 다원적 절충주의 경향에 관한 연구 -세계 4대 뮤지컬을 중심으로- (2013)

The purpose of this study is to examine the trend of plural eclecticism in costumes appearing on the stages of the world`s top 4 musicals based on the general researches and establishments made of the mentioned concept. The conclusions of this study are as follows. First, the aspects of eclectics appearing in overall pieces can be defined as situational eclecticism. It can be attributed to the dramatic elements contrasted in the storyline of the musical and occurs in mixture with various situations. Showing combinations of costumes from varying situations at once in the same stage makes the audience feel the dynamic elements of the piece. Second, the aspect of temporal eclecticism, which can be seen in the ``Phantom of the Opera`` regarding mixture of crinoline style and art nouveau style, resulted from the partial mixture of classical elements for maximizing visual beauty in the historical pieces. Third, the aspect of spatial eclecticism can be observed in the musical ``Miss Saigon``, which used costumes that combined multicultural elements by exposing different spaces and cultures such as America and Vietnam. It eclectically expresses the unique cultures and costumes of each country. Fourth, ``Les Miserables`` shows the aspect of situational eclecticism, through its use of mixture of situations in various aspects, and in particular, the male and female costumes that blur the boundaries of life, death, and costume, the mixture of people`s costume and aristocrat`s costume, and the situational elements where the good and evil are contrasted are integrated eclectically to make the story dramatic.
Infrared to ultraviolet measurements of two-photon absorption and n/sub 2/ in wide bandgap solids (1996)

The bound electronic nonlinear refractive index, n2, and two-photon absorption (2PA) coefficient, β, are measured in a variety of inorganic dielectric solids at the four harmonics of the Nd:YAG laser using Z scan. The specific materials studied are: barium fluoride (BaF2), calcite (CaCO3), potassium bromide (KBr), lithium fluoride (LiF), magnesium fluoride (MgF2), sapphire (Al2O3), a tellurite glass (75%TeO2+ 20%ZnO + 5%Na2O) and fused silica (SiO2). We also report n2 and β in three second-order, χ(2), nonlinear crystals: potassium titanyl phosphate (KTiOPO4 or KTP), lithium niobate (LiNbO3), and β-barium borate (β-BaB2O4 or BBO). Nonlinear absorption or refraction can alter the wavelength conversion efficiency in these materials. The results of this study are compared to a simple two-parabolic band model originally developed to describe zincblende semiconductors. This model gives the bandgap energy (Eg) scaling and spectrum of the change in absorption. The dispersion of n2 as obtained from a Kramers-Kronig transformation of this absorption change scales as E9-4. The agreement of this theory to data for semiconductors was excellent. However, as could be expected, the agreement for these wide bandgap materials is not as good, although general trends such as increasing nonlinearity with decreasing bandgap energy can be seen.
Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial (2016)

In premenopausal women with female sexual dysfunctions, self-administered, as desired, subcutaneous BMT was safe, effective, and well tolerated (NCT01382719).
Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid. (1997)

Capillary dropout is an initial event in diabetic retinopathy, but the etiology is unknown. Recent evidence suggests that similar events may occur in the diabetic choroid. We have developed a method to evaluate the relationship between the polymorphonuclear leukocytes (PMNs) and capillary dropout in the human diabetic choroid using alkaline phosphatase (APase) histochemistry to label blood vessels and nonspecific esterase activity to identify PMNs. The number and distribution of PMNs in diabetic and nondiabetic choroidal capillaries (choriocapillaris) were analyzed in the flat perspective and the tissue then flat embedded in glycol methacrylate for histological sectioning. The total number of PMNs was increased within the choriocapillaris in five diabetic eyes (170.9 +/- 12.9 PMNs/mm2 of choroid) compared with five nondiabetic eyes (84.2 +/- 16.9 PMNs/mm2; P < 0.001). PMNs were almost always within blood vessel lumens and not in interstitial tissue. In the diabetic choroid, increased numbers of PMNs were present in areas of choriocapillaris with pathological changes (loss in APase activity and choroidal neovascularization) compared with nonpathological choriocapillaris (205.1 +/- 46.9 PMNs/mm2 in pathological versus 152.3 +/- 23.4 PMNs/mm2 in nonpathological areas; P < 0.001). PMNs were often queued up within the lumens of capillaries, demonstrating loss in APase activity. We have observed an increased number of PMNs in diabetic choroid compared with control nondiabetic choroids, and PMNs in diabetic choroid were associated with loss in APase activity, which was related to loss in viable endothelial cells. The results suggest that PMNs contribute to vaso-occlusive processes and endothelial cell injury in the diabetic choroid.
Semiconductor laser to single-mode fiber coupler (1979)

Promising results of various coupling experiments between laser diodes and single-mode fibers to determine the optimum coupling method are reported. The cylindrical lens method is shown to be most efficient, with a coupling loss of 1.8 dB under optimum alignment conditions. More than -2 dB coupling efficiency is attained with a cylindrical lens whose radius is less than 8 microm. The laser to fiber coupling characteristics are estimated by Gaussian beam approximation. The optimum radius of a cylindrical lens, which gives maximum coupling efficiency, is derived by theoretical calculation, using the ray matrix method. The cylindrical lens alignment tolerance is also shown theoretically and experimentally.
Investigating the Graphitization Mechanism of SiO2 Nanoparticles in Chemical Vapor Deposition (2009)

The use of SiO(2) as a catalyst for graphitic nanostructures, such as carbon nanotubes and graphene, is a new and rapidly developing catalyst system. A key question is whether carbide phases form in the reaction. We show the formation of SiC from SiO(2) nanoparticles for the synthesis of graphitic carbon nanostructures via chemical vapor deposition (CVD) at 900 degrees C. Our findings point to the carbothermal reduction of SiO(2) in the CVD reaction. The inclusion of triethyl borate apparently accelerates the process and leads to improved yields. The study helps better understand the growth mechanisms at play in carbon nanotube and carbon nanofiber formation when using SiO(2) catalysts.
Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting (2016)

ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promoted by cytosine at rs609621 in the NSE 3' splice-site (3'ss), which is predominant in high cancer risk populations. NSE levels were deregulated in leukemias and were influenced by the identity of U2AF35 residue 34. We also identify splice-switching oligonucleotides (SSOs) that exploit competition of adjacent pseudoexons to modulate NSE levels. The U2AF-regulated exon usage in the ATM signalling pathway was centred on the MRN/ATM-CHEK2-CDC25-cdc2/cyclin-B axis and preferentially involved transcripts implicated in cancer-associated gene fusions and chromosomal translocations. These results reveal important links between 3'ss control and ATM-dependent responses to double-strand DNA breaks, demonstrate functional plasticity of intronic variants and illustrate versatility of intronic SSOs that target pseudo-3'ss to modify gene expression.
Frey's Syndrome - A Technical Remedyr (1975)

The symptoms of Frey's syndrome are occasionally of sufficient magnitude to warrant curative treatment. In four patients, a fascia lata graft was placed under the involved skin in an attempt to offer permanent relief from the cutaneous discomfort suffered during eating. Two of these patients have excellent long-term results. The other two patients were lost to long-term follow-up but were asymptomatic several months following grafting.
Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells (2001)

Tyrosine kinase receptors for angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) are expressed not only by endothelial cells but also by subsets of hematopoietic stem cells (HSCs). To further define their role in the regulation of postnatal hematopoiesis and vasculogenesis, VEGF and Ang-1 plasma levels were elevated by injecting recombinant protein or adenoviral vectors expressing soluble VEGF(165), matrix-bound VEGF(189), or Ang-1 into mice. VEGF(165), but not VEGF(189), induced a rapid mobilization of HSCs and VEGF receptor (VEGFR)2(+) circulating endothelial precursor cells (CEPs). In contrast, Ang-1 induced delayed mobilization of CEPs and HSCs. Combined sustained elevation of Ang-1 and VEGF(165) was associated with an induction of hematopoiesis and increased marrow cellularity followed by proliferation of capillaries and expansion of sinusoidal space. Concomitant to this vascular remodeling, there was a transient depletion of hematopoietic activity in the marrow, which was compensated by an increase in mobilization and recruitment of HSCs and CEPs to the spleen resulting in splenomegaly. Neutralizing monoclonal antibody to VEGFR2 completely inhibited VEGF(165), but not Ang-1-induced mobilization and splenomegaly. These data suggest that temporal and regional activation of VEGF/VEGFR2 and Ang-1/Tie-2 signaling pathways are critical for mobilization and recruitment of HSCs and CEPs and may play a role in the physiology of postnatal angiogenesis and hematopoiesis.
Programmed Death Ligand 2 in Cancer-Induced Immune Suppression (2012)

Inhibitory molecules of the B7/CD28 family play a key role in the induction of immune tolerance in the tumor microenvironment. The programmed death-1 receptor (PD-1), with its ligands PD-L1 and PD-L2, constitutes an important member of these inhibitory pathways. The relevance of the PD-1/PD-L1 pathway in cancer has been extensively studied and therapeutic approaches targeting PD-1 and PD-L1 have been developed and are undergoing human clinical testing. However, PD-L2 has not received as much attention and its role in modulating tumor immunity is less clear. Here, we review the literature on the immunobiology of PD-L2, particularly on its possible roles in cancer-induced immune suppression and we discuss the results of recent studies targeting PD-L2 in cancer.
Associations between ultrasound indices of follicular blood flow, oocyte recovery and preimplantation embryo quality (1996)

The aim of this study was to elucidate possible relationships between ultrasound indices of follicular blood flow, oocyte recovery and the subsequent production and morphological quality of preimplantation embryos. A total of 27 women with bilateral tubal occlusion, undergoing treatment for infertility by in-vitro fertilization and embryo transfer, contributed data from 29 cycles. Transvaginal ultrasonography with colour Doppler imaging and pulsed Doppler spectral analysis was used to obtain indices of blood flow for each follicle immediately before it was aspirated. The main outcome measures for each follicle were the pulsatility index, peak systolic velocity, recovery or non-recovery of an oocyte and the subsequent production or non-production of an embryo. A total of 126 follicles were studied, 102 oocytes were recovered and 58 embryos (49 at grades I or II) were produced. There were six clinical pregnancies (pregnancy rate 27.3% per embryo transfer, 22.2% per patient). There was a significant correlation (P < 0.0001, chi2 test) between whether or not follicular blood flow was detected and whether or not an oocyte was recovered. The sensitivity of a test based on the presence of detectable blood flow and the subsequent recovery of an oocyte was 74% and the positive predictive value was 93%. The peak systolic velocity (PSV, measured in cm/s, mean +/- SD) in follicles with detectable blood flow was significantly higher in follicles that were associated with the production of a preimplantation embryo (19.7 +/- 10.8) compared with those that were not (9.9 +/- 5.3, P < 0.0001, Student's t-test). There was a 70% chance of producing a grade I or II embryo if the follicular blood velocity was >/=10 cm/s, compared with 14% if the PSV was <10 cm/s, or 18% if no blood flow was detected. We conclude that there is a physiological relationship between follicular blood velocity, oocyte recovery and the production of a high-grade preimplantation embryo, which may form the basis of a useful clinical test.
Inhibition of Human O6-Alkylguanine-DNA Alkyltransferase and Potentiation of the Cytotoxicity of Chloroethylnitrosourea by 4(6)-(Benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine Derivatives and Analogues (1998)

A series of 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine derivatives and analogues of which 4(6)-benzyloxy groups were replaced with a (2-, 3-, or 4-fluorobenzyl)oxy or (2-, 3-, or 4-pyridylmethyl)oxy group, was synthesized. The abilities of these compounds to inhibit human O6-alkylguanine-DNA alkyltransferase (AGAT) in vitro and to potentiate the cytotoxicity of 1-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-3-(2-chloroethyl) -3-nitrosourea (ACNU) toward HeLa S3 cells were evaluated. 2,4-Diamino-6-[(2-fluorobenzyl)oxy]-5-nitropyrimidine (3) and 2,4-diamino-5-nitro-6-(2-pyridylmethoxy)pyrimidine (6), whose ortho positions of the 6-substituent are modified, were much weaker in terms of these abilities than the corresponding meta- or para-modified compounds. These results are consistent with those of our previous study using a series of O6-benzylguanine derivatives. All 5-nitrosopyrimidine derivatives examined exerted both stronger AGAT-inhibition and ACNU-enhancement abilities than the corresponding 5-nitro derivatives. Among a variety of compounds that we have examined to date, 2,4-diamino-6-[(4-fluorobenzyl)oxy]-5-nitrosopyrimidine (10) exhibited the strongest ability to inhibit AGAT, and its magnitude was 2.5 and 50 times those of 4-(benzyloxy)-2,6-diamino-5-nitrosopyrimidine (9) and O6-benzylguanine (1), respectively. A strong positive correlation was observed between the ability to inhibit AGAT and to potentiate the cytotoxicity of ACNU. This strongly indicates that 4(6)-(benzyloxy)pyrimidine derivatives and their analogues potentiate ACNU cytotoxicity by inhibiting AGAT activity. To characterize the reactivity of test compounds, alkyl-transfer reactions were also carried out using the biomimetic alkyl-transfer system.
Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene. (1986)

The dbl oncogene was initially isolated from a human diffuse B-cell lymphoma. Antisera from mice bearing tumors induced by this oncogene specifically detected a protein of about 66 kDa (p66) in dbl transformants. dbl cDNA-selected poly(A)+ RNA isolated from a transfectant clone expressing p66 directed the in vitro synthesis of this protein, establishing that it is encoded by dbl. Subcellular localization studies revealed that p66 is a cytoplasmic protein distributed between cytosol and crude membrane fractions. Moreover, p66 was shown to be a phosphoprotein, with phosphorylation specific to serine residues. Our characterization of the dbl-encoded protein appears to distinguish this transforming gene product from those of other known oncogenes.
Behavior of hematopoietic stem cells in a large animal. (1995)

To study the behavior of hematopoietic stem cells in vivo, we transplanted glucose-6-phosphate dehydrogenase (G6PD) heterozygous (female Safari) cats with small amounts of autologous marrow. The G6PD phenotypes of erythroid burst-forming units and granulocyte/macrophage colony-forming units were repeatedly assayed for 3.5-6 years after transplantation to track contributions of stem cell clones to the progenitor cell compartment. Two phases of stem cell kinetics were observed, which were similar to the pattern reported in comparable murine studies. Initially there were significant fluctuations in contributions of stem cell clones. Later clonal contributions to hematopoiesis stabilized. The initial phase of clonal disequilibrium, however, extended for 1-4.5 years (and not 2-6 months as seen in murine experiments). After this subsided, all progenitor cells from some animals expressed a single parental G6PD phenotype, suggesting that blood cell production could be stably maintained by the progeny of one (or a few) cells. As the hematopoietic demand of a cat (i.e., number of blood cells produced per lifetime) is over 600 times that of a mouse, this provides evidence that an individual hematopoietic stem cell has a vast self-renewal and/or proliferative capacity. The long phase of clonal instability may reflect the time required for stem cells to replicate sufficiently to reconstitute a large stem cell reserve.
Multispectral Transfer Network: Unsupervised Depth Estimation for All-Day Vision (2018)

To understand the real-world, it is essential to perceive in all-day conditions including cases which are not suitable for RGB sensors, especially at night. Beyond these limitations, the innovation introduced here is a multispectral solution in the form of depth estimation from a thermal sensor without an additional depth sensor.Based on an analysis of multispectral properties and the relevance to depth predictions, we propose an efficient and novel multi-task framework called the Multispectral Transfer Network (MTN) to estimate a depth image from a single thermal image. By exploiting geometric priors and chromaticity clues, our model can generate a pixel-wise depth image in an unsupervised manner. Moreover, we propose a new type of multitask module called Interleaver as a means of incorporating the chromaticity and fine details of skip-connections into the depth estimation framework without sharing feature layers. Lastly, we explain a novel technical means of stably training and covering large disparities and extending thermal images to data-driven methods for all-day conditions. In experiments, we demonstrate the better performance and generalization of depth estimation through the proposed multispectral stereo dataset, including various driving conditions.