gebhart/patrepeval huggingface dataset:
Fast Gauss Bilateral Filtering (2010)

Abstract In spite of high computational complexity, the bilateral filter and its modifications and extensions have recently become very popular image and shape processing tools. In this paper, we propose a fast and accurate approximation of the bilateral filter. Our approach combines a dimension elevation trick with a Fast Gauss Transform. First we represent the bilateral filter as a convolution in a high dimensional space. Then the convolution is efficiently approximated by using space partitioning and Gaussian function expansions. Advantages of our approach include linear computational complexity, user‐specified precision, and an ability to process high dimensional and non‐uniformly sampled data. We demonstrate capabilities of the approach by considering its applications to the image and volume denoising and high‐dynamic‐range tone mapping problems.
Managing the management: CORBA-based instrumentation of management systems (2003)

In liberalized (tele)communication markets, the goal of integrated management has become particularly demanding because now an arbitrary number of service providers need to dynamically exchange customer- and technology-related data. In this context, management systems are crucial for seamless interworking because they contain the management information that has to be shared between service providers: on the one hand, different service providers have chosen different management systems that are bound to specific, standardized management architectures and, due to the heterogeneity of the underlying frameworks, do not interoperate easily. Solutions for achieving interoperability between heterogeneous frameworks are one key factor towards integrated enterprise management and have been studied in the past. On the other hand, the provisioning of management instrumentation for the management systems themselves (i.e., the problem "how to manage the management") is still an open research question. The paper presents a novel approach to this problem by defining a MIB for management systems. It can be regarded as a step towards integrated enterprise management and is based on the viewpoint languages and concepts of RM-ODP; generic management models for distributed applications can then be refined to handle the specifics of management systems. A CORBA-based prototype implementation for managing management systems illustrates the applicability of our concepts.
Direct force measurements of the streptavidin–biotin interaction (1999)

The interaction between streptavidin and its ligand, biotin, were studied by direct force measurements. The complimentary approaches of surface force apparatus (SFA) and atomic force microscopy (AFM) were used to elucidate both long-range and short-range adhesive interactions of the streptavidin biotin interaction. The high spatial resolution of the SFA provided a detailed profile of the intersurface forces of apposing surfaces functionalized with streptavidin and biotin. Measurements obtained by the SFA corresponded to long and intermediate-range forces that are important in determining ligand receptor association. AFM was used to measure the unbinding force of individual streptavidin biotin complexes. These measurements revealed the short-range interactions (i.e. hydrophobic and hydrogen bonding forces) that stabilize the intermolecular bond.
Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm (1987)

Medical treatment of dystonia usually results in an incomplete response and is frequently unsuccessful. Peripheral surgical therapy is available for some focal dystonias, but may only offer temporary relief and may have unacceptable complications. We have used local injections of botulinum toxin into the appropriate muscles for treatment of disabling focal or segmental dystonia in 93 patients with torticollis, blepharospasm, oromandibular dystonia (OMD), limb dystonia, lingual dystonia, and dystonia adductor dysphonia, in addition to four patients with hemifacial spasm. Significant relief of motor symptoms was seen in 69% of the patients with blepharospasm and 64% of patients with torticollis; 74% of the latter group with pain experience relief. Relief of symptoms was noted in most patients with OMD and limb dystonia, and all with lingual dystonia, dystonic adductor spastic dysphonia, and those with hemifacial spasm. Benefit averaged 2 1/2-3 months initially; however some patients experienced longer relief with subsequent injections. Adverse effects were transient, although 2 patients developed antibodies against the toxin, and we documented evidence for distant effects in others. This approach of chemically weakening contracting muscles in focal dystonia offers many advantages over pharmacotherapy and surgical therapy. Additional experience is needed to explore the proper doses, and potential for long term adverse effects.
Benefits of the Novel Fiber-Laden Low-Viscosity Fluid System in Fracturing Low-Permeability Tight Gas Formations (2006)

Abstract Most of the low-permeability tight gas market that is treated by low-viscosity slickwater fracturing treatments results in ineffective propped fractures due to rapid proppant settling. Currently hybrid fracturing and ultra-lightweight proppants are employed for improving performance of slickwater treatments. The hybrid fracturing methodology uses a combination of linear and crosslinked gels to improve proppant placement. The disadvantages of existing lightweight proppants are their high cost and applicability only to reservoirs characterized by low closure stresses. Novel fiber-laden low-viscosity fluid technology has been developed to improve proppant transport for hydraulic fracturing in low-temperature tight gas formations. Such a system creates a fiber-based network within the fracturing fluid that decouples proppant settling from fluid viscosity. This network entangles proppant, dramatically reduces proppant settling, and provides a mechanical means to transport and place the proppant at greater distances from the wellbore. An additional advantage of the new system lies in fiber degradability, which leads to a nondamaged fracture conductivity with time. Fluid rheology of fiber-laden fluids was measured over a 150-230 °F temperature range under various fiber loadings. Studies showed that under bottomhole temperature and fluid pH fiber decompose and form a water-soluble species. During fiber degradation, the permeability of the fiber-laden system approaches the value of permeability for the baseline system without fiber. Compatibility study of the degradation byproducts with formation water showed no precipitate formation in high salinity environments. The results demonstrate that the new fiber technology ensures uniform proppant placement within a long fracture, provides permeability equal to pure proppant pack values, and offers higher production rates in comparison with conventional fracturing treatments.
STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment (2016)

STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it is unclear whether the inactivation of tumor suppressor genes, such as STK11/LKB1, exerts similar effects. In this study, we investigated the consequences of STK11/LKB1 loss on the immune microenvironment in a mouse model of KRAS-driven NSCLC. Genetic ablation of STK11/LKB1 resulted in accumulation of neutrophils with T-cell-suppressive effects, along with a corresponding increase in the expression of T-cell exhaustion markers and tumor-promoting cytokines. The number of tumor-infiltrating lymphocytes was also reduced in LKB1-deficient mouse and human tumors. Furthermore, STK11/LKB1-inactivating mutations were associated with reduced expression of PD-1 ligand PD-L1 in mouse and patient tumors as well as in tumor-derived cell lines. Consistent with these results, PD-1-targeting antibodies were ineffective against Lkb1-deficient tumors. In contrast, treating Lkb1-deficient mice with an IL6-neutralizing antibody or a neutrophil-depleting antibody yielded therapeutic benefits associated with reduced neutrophil accumulation and proinflammatory cytokine expression. Our findings illustrate how tumor suppressor mutations can modulate the immune milieu of the tumor microenvironment, and they offer specific implications for addressing STK11/LKB1-mutated tumors with PD-1-targeting antibody therapies.
A Survey on Web Tracking: Mechanisms, Implications, and Defenses (2017)

Privacy seems to be the Achilles’ heel of today’s web. Most web services make continuous efforts to track their users and to obtain as much personal information as they can from the things they search, the sites they visit, the people they contact, and the products they buy. This information is mostly used for commercial purposes, which go far beyond targeted advertising. Although many users are already aware of the privacy risks involved in the use of internet services, the particular methods and technologies used for tracking them are much less known. In this survey, we review the existing literature on the methods used by web services to track the users online as well as their purposes, implications, and possible user’s defenses. We present five main groups of methods used for user tracking, which are based on sessions, client storage, client cache, fingerprinting, and other approaches. A special focus is placed on mechanisms that use web caches, operational caches, and fingerprinting, as they are usually very rich in terms of using various creative methodologies. We also show how the users can be identified on the web and associated with their real names, e-mail addresses, phone numbers, or even street addresses. We show why tracking is being used and its possible implications for the users. For each of the tracking methods, we present possible defenses. Some of them are specific to a particular tracking approach, while others are more universal (block more than one threat). Finally, we present the future trends in user tracking and show that they can potentially pose significant threats to the users’ privacy.
Modulators of Leukotriene Biosynthesis and Receptor Activation (1996)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTModulators of Leukotriene Biosynthesis and Receptor ActivationClint D. W. Brooks and James B. SummersView Author Information Immunoscience Research Area, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-3500Cite this: J. Med. Chem. 1996, 39, 14, 2629–2654Publication Date (Web):July 5, 1996Publication History Received30 January 1996Published online5 July 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jm960088khttps://doi.org/10.1021/jm960088kreview-articleACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views784Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Antagonists,Inhibition,Inhibitors,Receptors Get e-Alerts
Electrogenerated chemiluminescence. XXI. Energy transfer from an exciplex to a rare earth chelate (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrogenerated chemiluminescence. XXI. Energy transfer from an exciplex to a rare earth chelateRonald E. Hemingway, Su-Moon Park, and Allen J. BardCite this: J. Am. Chem. Soc. 1975, 97, 1, 200–201Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://pubs.acs.org/doi/10.1021/ja00834a041https://doi.org/10.1021/ja00834a041research-articleACS PublicationsRequest reuse permissionsArticle Views259Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lack of competition results in efficient packaging of heterologous murine retroviral RNAs and reticuloendotheliosis virus encapsidation-minus RNAs by the reticuloendotheliosis virus helper cell line (1987)

We constructed recombinant reticuloendotheliosis virus (Rev)-derived and murine leukemia virus-derived vectors to characterize the specificity of packaging retroviral RNAs in Rev proteins. Using this approach, we further localized the Rev encapsidation sequence (E) to a 144-nucleotide region and determined that there are sequences in both the 5' and 3' halves of this region which are necessary in cis for viral replication. We found that the Rev E, like the murine leukemia virus E (psi), is position independent (R. Mann and D. Baltimore, J. Virol. 54:401-407, 1986). Also, a 156-nucleotide region of the Rev intron enhanced replication in a cis-acting fashion in the presence, but not in the absence, of helper virus. Finally, we showed that packaging of E- and heterologous retroviral genomes occurred efficiently in the Rev helper cell in the absence of competing E-containing (E+) viral RNAs.
Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells (2000)

Mammalian cells have the ability to proliferate under different nutrient environments by utilizing different combinations of the nutrients, especially glucose and the amino acids. Under the conditions often used in in vitro cultivation, the cells consume glucose and amino acids in great excess of what is needed for making up biomass and products. They also produce large amounts of metabolites with lactate, ammonia, and some non-essential amino acids such as alanine as the most dominant ones. By controlling glucose and glutamine at low levels, cellular metabolism can be altered and can result in reduced glucose and glutamine consumption as well as in reduced metabolite formation. Using a fed-batch reactor to manipulate glucose at a low level (as compared to a typical batch culture), cell metabolism was altered to a state with substantially reduced lactate production. The culture was then switched to a continuous mode and allowed to reach a steady-state. At this steady-state, the concentrations of cells and antibody were substantially higher than a control culture that was initiated from a batch culture without first altering cellular metabolism. The lactate and other metabolite concentrations were also substantially reduced as compared to the control culture. This newly observed steady-state was achieved at the same dilution rate and feed medium as the control culture. The paths leading to the two steady-states, however, were different. These results demonstrate steady-state multiplicity. At this new steady-state, not only was glucose metabolism altered, but the metabolism of amino acids was altered as well. The amino acid metabolism in the new steady-state was more balanced, and the excretion of non-essential amino acids and ammonia was substantially lower. This approach of reaching a more desirable steady-state with higher concentrations of cells and product opens a new avenue for high-density- and high-productivity-cell culture.
Antioxidant status in erythrocytes of cystic fibrosis children. (2001)

Activities of superoxide dismutase, catalase and glutathione peroxidase in erythrocytes of cystic fibrosis children were studied in order to estimate the severity of their deficiency. Our results point to increased susceptibility of erythrocytes of cystic fibrosis subjects to oxidative injury and indicate that the antioxidant status of patients should be carefully monitored.
Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice (1997)

Cholesterol esterification is involved in the regulation of cellular cholesterol content and has been hypothesized to play a role in important physiologic processes including intestinal cholesterol absorption, hepatic lipoprotein production, and macrophage foam cell formation in atherosclerotic lesions. Although initial studies of the mouse acyl CoA:cholesterol acyltransferase gene (Acact) suggested that its gene product was responsible for cholesterol esterification in most tissues, we observed recently that Acact-/- mice have only tissue-specific reductions in cholesterol esterification. To better understand the role of Acact in cholesterol esterification, we used in situ hybridization and immunoblotting to perform tissue expression studies in wild-type mice. We found high levels of Acact expression in steroidogenic tissues, sebaceous glands, and atherosclerotic lesions, but not in the liver or the small intestine. These data support the hypothesis that multiple cholesterol esterification enzymes exist in mammals and that another enzyme is likely to be responsible for cholesterol esterification activity in mouse liver and intestine.
Ionic polymer-metal composites: I. Fundamentals (2001)

This paper, the first in a series of four review papers, presents a brief summary of the fundamental properties and characteristics of ionic polymeric-metal composites (IPMCs) as biomimetic sensors, actuators and artificial muscles. The forthcoming three review papers, to follow this paper, will address in detail such fundamentals and, in particular, manufacturing techniques and the electronic and electromechanical characteristics of IPMCs (part II), the phenomenological modelling of the underlying sensing and actuation mechanisms in IPMCs (part III) and the potential application areas for IPMCs (part IV). This paper is a summary of all recent findings and current state-of-the art manufacturing techniques, phenomenological laws and mechanical and electrical characteristics. A number of methodologies in developing high-force-density IPMCs are also reported.
Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. (1986)

Simple single-gene disorders in humans can be genetically mapped by using traditional methods of linkage analysis and increasingly abundant restriction fragment length polymorphisms (RFLPs). Many human diseases and traits, however, can be expected to be genetically heterogeneous (i.e., caused by any one of several genes), and traditional linkage analysis is much less effective in such circumstances. We present two methods, interval mapping and simultaneous search, designed to exploit the full power of a linkage map of the DNA markers. For the simplest situations, only 1/3 as many affected families are needed to map a heterogeneous trait by using these methods. Only 1/5-1/50 as many are needed to detect that genetic heterogeneity is present.
High Resolution Radar (1987)

Application of the radar range equation to high-resolution radar high-resolution radar design high-range resolution waveforms and processing synthetic high-range resolution radar synthetic aperture radar inverse synthetic aperture radar (ISAR) three-dimensional imaging with monopulse radar target imaging with noncoherent radar systems applications for surveillance.
Pax genes and organogenesis (1997)

Pax genes are a family of developmental control genes that encode nuclear transcription factors. They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding activity. Originally, paired-box-containing genes were detected in Drosophila melanogaster, where they exert multiple functions during embryogenesis. In vertebrates, Pax genes are also involved in embryogenesis. Mutations in four out of nine characterized Pax genes have been associated with either congenital human diseases such as Waardenburg syndrome (PAX3), Aniridia (PAX6), Peter's anomaly (PAX6), renal coloboma syndrome (PAX2) or spontaneous mouse mutants (undulated (Pax1), Splotch (Pax3), Small eye (Pax6), Pax2(1)Neu), which all show defects in development. Recently, analysis of spontaneous and transgenic mouse mutants has revealed that vertebrate pax genes are key regulators during organogenesis of kidney, eye, ear, nose, limb muscles, vertebral column and brain. Like their Drosophila counterparts, vertebrate Pax genes are involved in pattern formation during embryogenesis, possibly by determining the time and place of organ initiation or morphogenesis. For most tissues, however, the nature of the primary developmental action of Pax transcription factors remains to be elucidated. One predominant theme is signal transduction during tissue interactions, which may lead to a position-specific regulation of cell proliferation.
Feature article. Nanocomposites (1992)

The use of nanocomposites in materials processing can lead to monophasic or multiphasic ceramics, glasses or porous materials, with tailored and improved properties. This review deals with a variety of nanocomposites such as sol–gel, intercalation, entrapment, electroceramic and structural ceramic types, which exhibit superior properties when compared to the monophasic or microcomposite alternatives. The utilization of nanocomposites in materials processing is forecasted to have a major impact in catalytic, sensor, optical, electroceramic and structural ceramic materials.