gebhart/patrepeval huggingface dataset:
Implementation Trade-Offs of Soft-Input Soft-Output MAP Decoders for Convolutional Codes (2012)

Soft-input soft-output (SISO) maximum a-posteriori (MAP) decoders for convolutional codes (CCs) are an integral part of many modern wireless communication systems. Specifically, SISO-MAP decoding forms the basis for turbo decoders, as, e.g., specified for HSDPA or 3GPP-LTE, or for iterative detection and decoding in multiple-input multiple-output wireless systems, such as IEEE 802.11n. In this paper, we investigate the silicon-area, throughput, and energy-efficiency trade-offs associated with SISO-MAP decoders based on the algorithm developed by Bahl, Cocke, Jelinek, and Raviv (BCJR). To this end, we develop radix-2 and radix-4 architectures for high-throughput SISO-MAP decoding of CCs having 4, 8, 16, 32, and 64 states and present corresponding implementation results in 180 nm, 130 nm, and 90 nm CMOS technology. We validate technology-scaling rules and finally demonstrate the use of the presented trade-off analysis by identifying the key design parameters for parallel turbo-decoder implementations.
Solar cells based on poly(3-alkyl)thiophenes and [60]fullerene: a comparative study (2002)

Photovoltaic cells made, at ambient conditions, from blends of regioregular poly(3-alkylthiophenes) and soluble fullerene derivatives are compared. It is shown that the cell performance is affected by the length of the donor side-chain, as it occurs in devices based on pure polythiophenes. The highest value of power conversion efficiency (0.84%) were obtained by using poly(3-hexylthiophene) and a fullerene concentration of 33-40% by weight. We anticipate a significant further improvement in power conversion efficiency upon a mild thermal treatment of the cells.
Effect of Intralesional a2-Interferon on Actinic Keratoses (1986)

The effect of intralesional alpha 2-interferon (IFN) on actinic keratoses was examined in this two-part study. In phase I, 11 of 12 lesions cleared following nine injections of IFN (5 X 10(5) IU per dose) compared with none of 12 keratoses injected with placebo. Smaller doses of IFN (1 X 10(5) IU and 1 X 10(4) IU per injection) produced clearing of 42% and 58% of lesions, respectively. The second phase, which was designed to investigate the optimum schedule for treatment with IFN, showed that a minimum of six injections of IFN (5 X 10(5) IU per injection) was necessary to clear 14 of 15 actinic keratoses. Although this mode of delivery is not practical for clinical use, intralesional alpha 2-IFN demonstrates biologic activity against actinic keratoses.
Blood and alveolar lymphocyte subsets in pulmonary cytomegalovirus infection after lung transplantation (2001)

Cytomegalovirus pulmonary infection is accompanied by only minor changes in BAL lymphocyte subpopulations. The study of BAL lymphocyte subpopulations therefore appears to be of limited clinical value in the diagnosis of pulmonary CMV infection. However, increased blood B-lymphocytes seems to be a clinical feature associated with CMV infection.
Distinct Cortical Anatomy Linked to Subregions of the Medial Temporal Lobe Revealed by Intrinsic Functional Connectivity (2008)

The hippocampus and adjacent cortical structures in the medial temporal lobe (MTL) contribute to memory through interactions with distributed brain areas. Studies of monkey and rodent anatomy suggest that parallel pathways converge on distinct subregions of the MTL. To explore the cortical areas linked to subregions of the MTL in humans, we examined cortico-cortical and hippocampal-cortical correlations using high-resolution, functional connectivity analysis in 100 individuals. MTL seed regions extended along the anterior to posterior axis and included hippocampus and adjacent structures. Results revealed two separate brain pathways that correlated with distinct subregions within the MTL. The body of the hippocampus and posterior parahippocampal cortex correlated with lateral parietal cortex, regions along the posterior midline including posterior cingulate and retrosplenial cortex, and ventral medial prefrontal cortex. By contrast, anterior hippocampus and the perirhinal/entorhinal cortices correlated with distinct regions in the lateral temporal cortex extending into the temporal pole. The present results are largely consistent with known connectivity in the monkey and provide a novel task-independent dissociation of the parallel pathways supporting the MTL memory system in humans. The cortical pathways include regions that have undergone considerable areal expansion in humans, providing insight into how the MTL memory system has evolved to support a diverse array of cognitive domains.
Antimicrobial peptides important in innate immunity (2011)

Antimicrobial peptides are present in all walks of life, from plants to animals, and they are considered to be endogenous antibiotics. In general, antimicrobial peptides are determinants of the composition of the microbiota and they function to fend off microbes and prevent infections. Antimicrobial peptides eliminate micro-organisms through disruption of their cell membranes. Their importance in human immunity, and in health as well as disease, has only recently been appreciated. The present review provides an introduction to the field of antimicrobial peptides in general and discusses two of the major classes of mammalian antimicrobial peptides: the defensins and the cathelicidins. The review focuses on their structures, their main modes of action and their regulation.
The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication (2006)

The hepatitis C virus (HCV) replicates on a membrane protein complex composed of viral proteins, replicating RNA, and altered cellular membranes. Small-molecule inhibitors of cellular lipid-cholesterol metabolism such as 25-hydroxycholesterol, cerulenin, lovastatin, and GGTI-286 all show a negative effect on HCV replication. Perturbation of host cell lipid and cholesterol metabolism can disrupt replication complexes by altering membranous structures where replication occurs. Changes in cholesterol and (or) lipid composition can have a general effect on membrane structure. Alternatively, metabolic changes can exert a more subtle influence over replication complexes by altering localization of host proteins through alterations in lipid anchoring. Here, we use Huh-7 cells harboring subgenomic HCV replicons to demonstrate that 25-hydroxycholesterol, cerulenin, lovastatin, and GGTI-286 do not disrupt the membranous web where replication occurs, whereas cholesterol-depleting agents such as beta-cyclodextrin do. Cellular imaging suggests that the HCV RNA can remain associated with subcellular compartments connected with replication complexes in the presence of metabolic inhibitors. Therefore, at least 2 different molecular mechanisms are possible for the inhibition of HCV replication through the modulation of cellular lipid and cholesterol metabolism.
Broadly Distributed Chemical Reactivity of Natural Antibodies Expressed in Coordination with Specific Antigen Binding Activity (2003)

Antibody (Ab) nucleophilic reactivity was studied using hapten and polypeptide antigens containing biotinylated phosphonate diester groups (covalently reactive antigen analogs, CRAs). Polyclonal IgG from healthy donors formed covalent adducts with a positively charged hapten CRA at levels superior to trypsin. Each of the 16 single chain Fv clones studied expressed a similar reactivity, indicating the V domain location of the nucleophiles and their broad distribution in diverse Abs. The formation of hapten CRA-Fv adducts was correlated with Fv proteolytic activity determined by cleavage of a model peptide substrate. Despite excellent nucleophilicity, proteolysis by IgG proceeded at lower rates than trypsin, suggesting that events occurring after nucleophilic attack on the substrate limit the rate of Ab proteolysis. The extracellular domain of the epidermal growth factor receptor with phosphonate diester groups at Lys side chains and a synthetic peptide corresponding to residues 421- 431 of human immunodeficiency virus glycoprotein (gp) 120 with the phosphonate diester at the C terminus formed covalent adducts with specific polyclonal and monoclonal Abs raised by immunization with epidermal growth factor receptor and synthetic gp120-(421- 436) devoid of phosphonate diester groups, respectively. Adduct formation was inhibited by extracellular domain of the epidermal growth factor receptor (exEGFB) and synthetic gp120-(421- 436) devoid of phosphonate groups, suggesting that the nucleophiles are located within the antigen binding sites. These results suggest the innate character of the Ab nucleophilic reactivity, its functional coordination with non-covalent adaptive binding interactions developing over the course of B cell maturation, and novel routes toward permanent inhibition of Abs.
Tunable optical heterodyne receiver for coherent FDM broadcasting systems (1988)

A tunable optical heterodyne receiver for a coherent FDM broadcasting system has been developed, using a wavelength tunable local DBR LD and polarization diversity. In the 8 channel FDM experimental system, 114 GHz capture range, 80 GHz lock range and high speed arbitrary channel selection were realized. Also, it was confirmed that there was no crosstalk penalty in the 400 Mb/s FSK FDM system.
Pentafluorophenyl Ester-Functionalized Phosphorylcholine Polymers: Preparation of Linear, Two-Arm, and Grafted Polymer–Protein Conjugates (2012)

Novel pentafluorophenyl (PFP)-ester-functionalized phosphorylcholine (PC) polymers of different architectures were prepared and conjugated to lysozyme as a model protein. Linear and two-arm poly(2-methacryloyloxyethyl phosphorylcholine) (polyMPC) structures containing PFP functionality at the chain-end were prepared by atom transfer radical polymerization (ATRP) from novel initiators. Additional conjugates were prepared from phosphorylcholine-substituted cyclooctene (PC-COE) polymers containing PFP-ester bearing comonomers. The polymer-protein conjugates were characterized by HPLC, FPLC, and DLS and were seen to retain most (~80% or greater) of their native enzymatic activity. Pharmacokinetic profiles of the polymer-protein conjugates were studied in mice and found to increase the circulation half-life compared with lysozyme alone.
Association between lifestyle factors and plasma adiponectin levels in Japanese men (2005)

Our findings show that adiponectin levels in general Japanese men are independently related to smoking, dietary factors, and physical exercise. We think that lifestyle habits might independently modulate adiponectin levels and that adiponectin might be the useful biomarker helping people to avoid developing type 2 diabetes and cardiovascular disease by modifying their lifestyles.
Imaging COX‐2 expression in cancer using PET/SPECT radioligands: current status and future directions (2013)

The role of cyclooxygenase (COX)-2 as a driving force in early tumourigenesis and the current interest in the combination of COX-2 inhibitors with standard therapy in clinical trials creates an urgent need to establish clinically relevant diagnostic tests for COX-2 expression. Molecular imaging using small-molecule probes radiolabelled for both positron emission tomography (PET) and single photon emission computed tomography (SPECT) offers the potential to meet this need, providing a minimally invasive readout for the whole disease burden. This review summarises current approaches to the radiolabelling of small-molecule COX-2 inhibitors and their analogues for PET and SPECT imaging, and gives an overview of their biological evaluation and likely success of clinical application.
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury (1999)

Heme oxygenase (HO) catalyzes the conversion of heme to carbon monoxide, iron, and biliverdin, which is immediately reduced to bilirubin (BR). Two HO active isozymes exist: HO1, an inducible heat shock protein, and HO2, which is constitutive and highly concentrated in neurons. We demonstrate a neuroprotective role for BR formed from HO2. Neurotoxicity elicited by hydrogen peroxide in hippocampal and cortical neuronal cultures is prevented by the phorbol ester, phorbol 12-myristate 13-acetate (PMA) via stimulation of protein kinase C. We observe phosphorylation of HO2 through the protein kinase C pathway with enhancement of HO2 catalytic activity and accumulation of BR in neuronal cultures. The neuroprotective effects of PMA are prevented by the HO inhibitor tin protoporphyrin IX and in cultures from mice with deletion of HO2 gene. Moreover, BR, an antioxidant, is neuroprotective at nanomolar concentrations.
Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). (2006)

Cancer/testis (CT) antigens are the protein products of germ line-associated genes that are activated in a wide variety of tumors and can elicit autologous cellular and humoral immune responses. CT antigens can be divided between those that are encoded on the X chromosome (CT-X antigens) and those that are not (non-X CT antigens). Among the CT-X antigens, the melanoma antigen gene (MAGE) family, defined by a shared MAGE homology domain (MHD), is the largest. CT-X genes are frequently expressed in a coordinate manner in cancer cells, and their expression appears to be modulated by epigenetic mechanisms. The expression of CT-X genes is associated with advanced disease and poor outcome in different tumor types. We used the yeast two-hybrid system to identify putative MHD-interacting proteins. The MHD of MAGE-C1 (CT7) was used as bait to screen a human testis cDNA library. This study identified NY-ESO-1 (CT6) as a MAGE-C1 binding partner. Immunoprecipitation and immunofluorescence staining confirmed MAGE-C1 interaction with NY-ESO-1, and cytoplasmic co-localization of both proteins in melanoma cells. Co-expression of these two genes was found to occur in cancer cell lines from different origins, as well as in primary tumors (multiple myeloma and non-small cell lung cancer samples). This is the first report of direct interaction between two CT antigens and may be pertinent in the light of the frequently coordinated expression of these proteins.
Database Systems: The Complete Book (2001)

From the Publisher:
This introduction to database systems offers a readable comprehensive approach with engaging, real-world examplesusers will learn how to successfully plan a database application before building it. The first half of the book provides in-depth coverage of databases from the point of view of the database designer, user, and application programmer, while the second half of the book provides in-depth coverage of databases from the point of view of the DBMS implementor. The first half of the book focuses on database design, database use, and implementation of database applications and database management systemsit covers the latest database standards SQL:1999, SQL/PSM, SQL/CLI, JDBC, ODL, and XML, with broader coverage of SQL than most other books. The second half of the book focuses on storage structures, query processing, and transaction managementit covers the main techniques in these areas with broader coverage of query optimization than most other books, along with advanced topics including multidimensional and bitmap indexes, distributed transactions, and information integration techniques. A professional reference for database designers, users, and application programmers.
Highly stretchable optical sensors for pressure, strain, and curvature measurement (2015)

Recent advances in soft sensors using microfluidic liquid conductors enabled sensing of large deformation of soft structures. However, the use of liquids as conductive media carries a risk of leakage in many cases. Furthermore, it could be harmful when exposed to the human body in certain applications. To address these issues, a different sensing mechanism was proposed: highly stretchable optical sensors that could detect multiple modes of deformation. The method of operation involves a simple waveguide and its housing which are both made of silicone elastomer. The soft waveguide is coated with a thin gold reflective layer to encapsulate light propagating internally, with an light-emitting diode (LED) and a photodiode embedded at each end. When the sensor is stretched, compressed, or bent, micro-cracks within the reflective layer form and allow part of the light to escape, resulting in optical power losses in the light transmission. In this paper, we describe the design and fabrication of the proposed soft sensors. A prototype was created and characterized for pressure, strain, and curvature up to 350 kPa, 90%, and 0.12 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , respectively, showing promising results of reasonable repeatability and linearity in certain ranges.
Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTApplications of Orthogonal "Click" Chemistries in the Synthesis of Functional Soft MaterialsRhiannon K. Iha†, Karen L. Wooley*†‡, Andreas M. Nyström§, Daniel J. Burke⊥, Matthew J. Kade⊥, and Craig J. Hawker*⊥View Author Information Department of Chemistry, Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri 63130, Department of Chemistry, Texas A&M University, College Station, Texas 77842, Cancer Center Karolinska, Department of Oncology-Pathology CCK, R8:03 Karolinska Hospital and Institute, SE-171 76 Stockholm, Sweden, and Department of Chemistry and Biochemistry, Department of Materials, and Materials Research Laboratory, University of California, Santa Barbara, California 93106* To whom correspondence should be addressed. E-mail addresses: [email protected]; [email protected]†Washington University in Saint Louis.‡Texas A&M University.§Karolinska Hospital and Institute.⊥University of California, Santa Barbara.Cite this: Chem. Rev. 2009, 109, 11, 5620–5686Publication Date (Web):November 11, 2009Publication History Received6 April 2009Published online11 November 2009Published inissue 11 November 2009https://pubs.acs.org/doi/10.1021/cr900138thttps://doi.org/10.1021/cr900138treview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views29488Altmetric-Citations1344LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Functionalization,Modification,Polymers,Radical polymerization Get e-Alerts
Phase I Escalation and Expansion Study of Bemarituzumab (FPA144) in Patients With Advanced Solid Tumors and FGFR2b-Selected Gastroesophageal Adenocarcinoma (2020)

Overall, bemarituzumab seems to be well tolerated and demonstrated single-agent activity as late-line therapy in patients with advanced-stage GEA. Bemarituzumab is currently being evaluated in combination with chemotherapy in a phase III trial as front-line therapy for patients with high FGFR2b-overexpressing advanced-stage GEA.
Synthesis and in Vivo Evaluation of New Contrast Agents for Cardiac MRI (1999)

Analogues 2-6 of N(3),N(6)-bis(2'-myristoyloxyethyl)-1, 8-dioxotriethylenetetraamine-N,N,N',N'-tetraacetic acid (BME-DTTA) (1), which like 1 are also based on the DTTA structure but contain shorter fatty acyl chains, were synthesized to improve the water solubility of the corresponding gadolinium complexes. The gadolinium complexes of 1 and 3-5 have very low solubility in water. Thus liposomal preparations are necessary for their in vivo MRI application. These liposomal preparations retain high in vitro relaxivities (27.1, 21.57, 20.32, 23.1 s(-1) mM(-1), respectively) and induce sustained MRI signal intensity enhancements (67.2, 38.4, 52.1, 41.7 in arbitrary units, respectively). The gadolinium complex of 2 is quite soluble in water. Its lifetime in the blood stream, however, is short. The gadolinium complex of analogue 6, N-(2-butyryloxyethyl)-N'-(2-ethyloxyethyl)-N,N'-bis[N' ',N' '-bis(carboxymethyl)acetamido]-1,2-ethanediamine (ABE-DTTA), has demonstrated its potential as a water-soluble, cardiac-specific, MRI contrast agent. It is completely soluble in water at a 25 mM concentration, allowing the preparation of an injectable dose. The in vitro relaxivity of the complex is 16.24 s(-1) mM(-1). The agent shows a specific accumulation in the heart tissue reaching its maximum within 15 min after administration, inducing a sustained MRI signal intensity enhancement of 43.6%. This enhancement lasts for at least 3 h, thus indicating a reasonably long lifetime of this contrast agent in the myocardium without deleterious effects on heart function parameters.
HPV detection and measurement of HPV-16, telomerase, and survivin transcripts in colposcopy clinic patients (2001)

The detection of HPV-16 or cellular survivin or telomerase transcripts did not accurately predict the grade of CIN in the samples. The detection of HPV risk types correlated well with the grade of CIN; however, the referral grade smear was the most accurate predictor of the severity of the lesion. Of the 35 different HPV types detected, 18 are not included in the HPV hybrid capture II commercial test kit. The use of such kits would have missed HPV infection in 4.3% of clinic patients with CIN 2/3 lesions and 15.4% with CIN 0/1.
DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro‐OmpC protein in Escherichia coli (1983)

The osmoregulated ompC gene of Escherichia coli was cloned and the DNA sequence of a fragment encompassing the promoter region and a portion of the coding region was determined. There were no obvious homologies in the DNA sequences of the promoter regions of the ompC and ompF genes, in contrast to those of the coding regions of the two genes, both of which code for the matrix porins (major outer membrane proteins) and form passive diffusion pores. The amino acid sequence of the signal peptide of pro-OmpC protein was also deduced from the DNA sequence.
Multimodality Imaging of IL-18–Binding Protein-Fc Therapy of Experimental Lung Metastasis (2008)

IL-18bp-Fc therapy can inhibit 4T1 breast cancer experimental lung metastasis. Noninvasive multimodality molecular imaging is a powerful tool for evaluating the tumor targeting efficiency/pharmacokinetics of the drug and effective monitoring of the therapeutic response.