gebhart/patrepeval huggingface dataset:
The NeXT Book (1989)

Uterine leiomyoma is the most common benign tumour occurring in women in the reproductive age. It is typically found during the middle and later reproductive years. The prevalence quoted in literature ranges from 20-50% based on post mortem studies. The symptoms usually reported by women with fibroids are the following: abnormal gynaecologic haemorrhage, chronic pelvic pain, dyspareunia, as well as urinary and bowel symptoms, urinary frequency or retention and, in some cases, infertility. During pregnancy, premature labor might be caused, interfering with the position of the fetus or abortion could be induced. However, only 30% of the women develop symptoms, most of them being asymptomatic. It was proved that the factors that can cause fibroids are the following: genetic, hormonal, and growth factors, especially transforming the growth factor beta (TGFb)-related cellular changes. As diagnosis tools, studies are revealing that ultrasound has been shown to be an insufficient method of myoma mapping, and magnetic resonance imaging should be preferred for surgical therapy planning. The contour of the endometrial cavity is delineated by using trans vaginal ultrasound and saline infusion hysterosonography, but hysteroscopy is the gold standard to evaluate the uterine cavity.
AAV-Mediated Expression of Vascular Endothelial Growth Factor Induces Choroidal Neovascularization in Rat (2003)

In this study, a highly reproducible animal model of long-lasting CNV was developed. This model is being used to test antiangiogenic molecules to reduce or inhibit CNV and could be extended to primates.
Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer. (1989)

Five hundred and twenty seven colorectal carcinomas were reviewed histologically. A multivariate analysis (Cox) was used to test the prognostic importance of certain histological features (invasiveness, inflammatory reaction, and amount of fibrous tissue) at the tumour edge after allowance had been made for clinicopathological stage, tumour site, and histological type and grade. A poorly defined tumour border, lack of inflammatory reaction, and a pronounced fibrosis (desmoplasia) at the tumour edge were associated with unfavourable stage distributions, but each of these features also had an independent effect on prognosis.
Single-Bond Formation and Characterization with a Scanning Tunneling Microscope (1999)

A scanning tunneling microscope (STM) was used to manipulate the bonding of a carbon monoxide (CO) molecule and to analyze the structure and vibrational properties of individual products. Individual iron (Fe) atoms were evaporated and coadsorbed with CO molecules on a silver (110) surface at 13 kelvin. A CO molecule was transferred from the surface to the STM tip and bonded with an Fe atom to form Fe(CO). A second CO molecule was similarly transferred and bonded with Fe(CO) to form Fe(CO)(2). Controlled bond formation and characterization at the single-bond level probe chemistry at the spatial limit.
Chemistry of alkenyl azlactones. IV. Preparation and properties of telechelic acrylamides derived from amine‐terminated oligomers (1984)

Abstract The ring‐opening, nucleophilic addition of amine‐terminated oligomers to alkenyl azlactones was exploited to prepare reactive, that is, in free radical polymerizations, oligomers that could be used in 100% solids resin systems. Acrylamide‐functional oligomers resulted from the reaction that used 2‐vinyl‐4,4‐dimethylazlactone, whereas methacrylamide‐functional oligomers were produced with 2‐isopropenyl‐4,4‐dimethylazlactone. The overall reaction took place under mild conditions, for example, a few hours at room temperature, and was particularly free of side reactions. Examination of reaction rates with the two alkenyl azlactones revealed that the 2‐vinyl derivative reacted ca. four times faster. The (meth)acrylamide‐terminated resins were characterized by IR, NMR, and molecular weight analyses.
Work Function in Alkali and Noble Metals (1980)

Abstract The pseudopotential approach is applied for the calculation of the work function of alkali and noble metals. The results indicate that the effective mass contributes significantly to the work function. The results agree well with the experimental value.
The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation (2014)

Lineage-specific transcription factors (TFs) display instructive roles in directly reprogramming adult cells into alternate developmental fates, in a process known as transdifferentiation. The present study analyses the hypothesis that despite being fast, transdifferentiation does not occur in one step but is rather a consecutive and hierarchical process. Using ectopic expression of Pdx1 in human liver cells, we demonstrate that while glucagon and somatostatin expression initiates within a day, insulin gene expression becomes evident only 2-3 days later. To both increase transdifferentiation efficiency and analyze whether the process indeed display consecutive and hierarchical characteristics, adult human liver cells were treated by three pancreatic transcription factors, Pdx1, Pax4 and Mafa (3pTFs) that control distinct hierarchical stages of pancreatic development in the embryo. Ectopic expression of the 3pTFs in human liver cells, increased the transdifferentiation yield, manifested by 300% increase in the number of insulin positive cells, compared to each of the ectopic factors alone. However, only when the 3pTFs were sequentially supplemented one day apart from each other in a direct hierarchical manner, the transdifferentiated cells displayed increased mature β-cell-like characteristics. Ectopic expression of Pdx1 followed by Pax4 on the 2(nd) day and concluded by Mafa on the 3(rd) day resulted in increased yield of transdifferentiation that was associated by increased glucose regulated c-peptide secretion. By contrast, concerted or sequential administration of the ectopic 3pTFs in an indirect hierarchical mode resulted in the generation of insulin and somatostatin co-producing cells and diminished glucose regulated processed insulin secretion. In conclusion transcription factors induced liver to pancreas transdifferentiation is a progressive and hierarchical process. It is reasonable to assume that this characteristic is general to wide ranges of tissues. Therefore, our findings could facilitate the development of cell replacement therapy modalities for many degenerative diseases including diabetes.
Role of Conduction Velocity Restitution and Short-Term Memory in the Development of Action Potential Duration Alternans in Isolated Rabbit Hearts (2008)

Our results provide new insight into the mechanisms underlying SDA formation in the rabbit heart. Specifically, our results suggest that a new mechanism associated with short-term memory underlies SDA formation in the heart, in addition to steep CV restitution.
Fully automated, deep learning segmentation of oxygen-induced retinopathy images (2017)

Oxygen-induced retinopathy (OIR) is a widely used model to study ischemia-driven neovascularization (NV) in the retina and to serve in proof-of-concept studies in evaluating antiangiogenic drugs for ocular, as well as nonocular, diseases. The primary parameters that are analyzed in this mouse model include the percentage of retina with vaso-obliteration (VO) and NV areas. However, quantification of these two key variables comes with a great challenge due to the requirement of human experts to read the images. Human readers are costly, time-consuming, and subject to bias. Using recent advances in machine learning and computer vision, we trained deep learning neural networks using over a thousand segmentations to fully automate segmentation in OIR images. While determining the percentage area of VO, our algorithm achieved a similar range of correlation coefficients to that of expert inter-human correlation coefficients. In addition, our algorithm achieved a higher range of correlation coefficients compared with inter-expert correlation coefficients for quantification of the percentage area of neovascular tufts. In summary, we have created an open-source, fully automated pipeline for the quantification of key values of OIR images using deep learning neural networks.
A Nonadditive Quantum Code (1997)

Every good quantum error-correcting code discovered thus far, such as those known as ``stabilizer'' or ``additive'' codes, has had the structure of an eigenspace of an Abelian group generated by tensor products of Pauli matrices. In this Letter we present the first example of a code that is better than any code of this type. It encodes six states in five qubits and can correct the erasure of any single qubit.
Pattern Discovery Techniques for Music Audio (2003)

Human listeners are able to recognize structure in music through the perception of repetition and other relationships within a piece of music. This work aims to automate the task of music analysis. Music is "explained" in terms of embedded relationships, especially repetition of segments or phrases. The steps in this process are the transcription of audio into a representation with a similarity or distance metric, the search for similar segments, forming clusters of similar segments, and explaining music in terms of these clusters. Several transcription methods are considered: monophonic pitch estimation, chroma (spectral) representation, and polyphonic transcription followed by harmonic analysis. Also, several algorithms that search for similar segments are described. These techniques can be used to perform an analysis of musical structure, as illustrated by examples.
The plant geneticist’ contribution toward changing lipid and amino acid composition of safflower (1972)

Abstract Current research on the fatty acid composition of the seed oil of safflower ( Carthamus tinctorius L.) has shown the following: (1) there is a possibility that the oleic acid content can be increased above 80%, though probably not above 85%, by use of modifying genes and the major gene ol ; (2) wild species do not look very promising as a source of genes for modifying fatty acid composition; (3) commercially grown high linoleic and high oleic types are temperature stable; (4) an experimental type with about equal amounts of oleic and linoleic acids is responsive to temperature, with high temperature increasing oleic acid and low temperature increasing linoleic acid; and (5) stearic acid in another experimental type with higher levels of stearic acid (5–10%) is reduced by low temperatures.
Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli (1994)

The product of the ftsW gene has been identified as a polypeptide that, like the related RodA protein, shows anomalous mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. FtsW is produced at low levels that can be increased by altering the translation initiation region of the mRNA. Overproduction of FtsW strongly inhibits cell growth. A new mutant allele, ftsW201, causes a temperature-dependent block in the initiation stage of cell division which is similar to the division block in ftsZ mutants. The block in initiation of division in the ftsW201 allele is shown to be independent of FtsZ or the FtsZ inhibitor, SulA. In addition, the ftsW201 mutant is hypersensitive to overproduction of the division initiation protein FtsZ at the permissive temperature. Our results suggest a role for FtsW in an early stage of division which may involve an interaction with FtsZ.
Effects of fibre interactions on conductivity, within a knitted fabric stretch sensor (2003)

Fabric sensors, when incorporated into clothing, can be used to create intuitive interfaces to embedded electronics and enable the dynamic motion of the wearer to be unobtrusively determined, enabling many new applications to be developed in the areas of sport, games and medical. This work describes the operation of a knitted fabric stretch sensor, and the fibre interactions that lead to the observed resistance change when the sensor is subjected to a stretching force. Through the understanding of the process by which this occurs, fabric sensors may be knitted that maximise this effect in a predictable manner.
Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus (2016)

Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge because of the emergence of resistance to numerous conventional antibiotics. Due to their unique mode of action, antimicrobial peptides are novel alternatives to traditional antibiotics for tackling the issue of bacterial multidrug resistance. Herein, we investigated the antibacterial activity of two short novel peptides (WR12, a 12 residue peptide composed exclusively of arginine and tryptophan, and D-IK8, an eight residue β-sheet peptide) against multidrug resistant staphylococci. In vitro, both peptides exhibited good antibacterial activity against MRSA, vancomycin-resistant S. aureus, linezolid-resistant S. aureus, and methicillin-resistant S. epidermidis. WR12 and D-IK8 were able to eradicate persisters, MRSA in stationary growth phase, and showed significant clearance of intracellular MRSA in comparison to both vancomycin and linezolid. In vivo, topical WR12 and D-IK8 significantly reduced both the bacterial load and the levels of the pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in MRSA-infected skin lesions. Moreover, both peptides disrupted established in vitro biofilms of S. aureus and S. epidermidis significantly more so than traditional antimicrobials tested. Taken together, these results support the potential of WR12 and D-IK8 to be used as a topical antimicrobial agent for the treatment of staphylococcal skin infections.
COMPUTER TELEPHONE INTEGRATION (1999)

From the Publisher:
Learn how CTI works and how you can make it work for your company. Using real-life examples, this book shows how computer-supported telephony applied to call centers has already given many companies a significant edge over their competitors. The author analyzes the benefits CTI can bring to your organization such as increased quality of customer service and resulting customer satisfaction, dramatic cost savings and increased revenue, an enhanced corporate image, and employee job satisfaction through convenience and system efficiency.
Improved Stereo Matching with Constant Highway Networks and Reflective Confidence Learning (2017)

We present an improved three-step pipeline for the stereo matching problem and introduce multiple novelties at each stage. We propose a new highway network architecture for computing the matching cost at each possible disparity, based on multilevel weighted residual shortcuts, trained with a hybrid loss that supports multilevel comparison of image patches. A novel post-processing step is then introduced, which employs a second deep convolutional neural network for pooling global information from multiple disparities. This network outputs both the image disparity map, which replaces the conventional winner takes all strategy, and a confidence in the prediction. The confidence score is achieved by training the network with a new technique that we call the reflective loss. Lastly, the learned confidence is employed in order to better detect outliers in the refinement step. The proposed pipeline achieves state of the art accuracy on the largest and most competitive stereo benchmarks, and the learned confidence is shown to outperform all existing alternatives.
Studies on stable diazoalkanes as potential fluorogenic reagents. I. 7-Substituted 4-diazomethylcoumarins. (1983)

As a new type of stable diazoalkane, 4-diazomethylcoumarins (4) bearing various 7-substituents were prepared for potential use in introducing fluorophores into acidic substances. Selenium dioxide oxidation of 4-methylcoumarins to the corresponding coumarin-4-carbaldehydes followed by triethylamine-mediated Bamford-Stevens reaction of their tosylhydrazones readily gave 4 as excellently stable and almost non-fluorescent crystals, exhibiting characteristic diazomethyl 1H- and 13C-nuclear magnetic resonance signals. Labeling reactions of carboxylic acids using 4 in refluxing chloroform in the presence of silica gel catalyst gave excellent yields of fluorescent coumarin-4-ylmethyl esters. In view of their stability, accessibility and fluorogenicity, these compounds (4), especially those bearing 7-methoxy and 7-acetyloxy substituents, should be practically useful fluorogenic reagents for carboxylic acids.
A prospective real-world analysis of erenumab in refractory chronic migraine (2020)

Erenumab may be an effective and well tolerated therapy for medically refractory CM patients with and without medication overuse.
A novel location-based service and architecture (2002)

This paper re-introduces the concept of service provider choice within hierarchical wireless networks of the future. The service provider does not have to be a PCS, cellular, or satellite carrier. The service provider might have agreements with multiple PCS, cellular, or satellite carriers to provide wireless services to its subscribers. The concepts of location billing and third generation networks have been studied in the past, but the concept of enabling users to switch between service providers based on their location is certainly novel. The objective is to present a generic service description of this concept and to propose a basic architecture that may foster future study. This paper is not a feasibility study, although it identifies the issues that may need to be considered to determine the viability of service provider choice based on a subscriber's location.
The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases (1996)

The mitogen-activated protein (MAP) kinase family includes extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38/RK/CSBP (p38) as structurally and functionally distinct enzyme classes. Here we describe two new dual specificity phosphatases of the CL100/MKP-1 family that are selective for inactivating ERK or JNK/SAPK and p38 MAP kinases when expressed in COS-7 cells. M3/6 is the first phosphatase of this family to display highly specific inactivation of JNK/SAPK and p38 MAP kinases. Although stress-induced activation of p54 SAPKbeta, p46 SAPKgamma (JNK1) or p38 MAP kinases is abolished upon co-transfection with increasing amounts of M3/6 plasmid, epidermal growth factor-stimulated ERK1 is remarkably insensitive even to the highest levels of M3/6 expression obtained. In contrast to M3/6, the dual specificity phosphatase MKP-3 is selective for inactivation of ERK family MAP kinases. Low level expression of MKP-3 blocks totally epidermal growth factor-stimulated ERK1, whereas stress-induced activation of p54 SAPKbeta and p38 MAP kinases is inhibited only partially under identical conditions. Selective regulation by M3/6 and MKP-3 was also observed upon chronic MAP kinase activation by constitutive p21(ras) GTPases. Hence, although M3/6 expression effectively blocked p54 SAPKbeta activation by p21(rac) (G12V), ERK1 activated by p21(ras) (G12V) was insensitive to this phosphatase. ERK1 activation by oncogenic p21(ras) was, however, blocked totally by co-expression of MKP-3. This is the first report demonstrating reciprocally selective inhibition of different MAP kinases by two distinct dual specificity phosphatases.
Use of Twice-Daily Exenatide in Basal Insulin–Treated Patients With Type 2 Diabetes (2011)

Alliance of Eli Lilly and Company and Amylin Pharmaceuticals.
Coexpression of intermediate filament polypeptides in human fetal and adult tissues. (1987)

Tissues from human fetuses (12 to 14 weeks) were studied by using immunohistochemical methods, with special emphasis on coexpression of intermediate filaments. Well-characterized antibodies, monoclonal as well as polyclonal were used. Indirect immunoperoxidase staining disclosed simultaneous expression of cytokeratin and vimentin, or vimentin and desmin in several tissues, whereas some other tissues coexpressed three classes of intermediate filaments, i.e., cytokeratin, vimentin, and desmin. Coexpression of cytokeratin and vimentin was seen in immature tubules of the kidney localized in the blastema and in one case in a small area of the epithelium of the tongue. Coexpression of vimentin and desmin was found in stromal cells of the medulla of the kidney, in stromal cells of the decidua (maternal tissue) and in muscle cells in blood vessels of small intestine, kidney and decidua. Coexpression of cytokeratin, vimentin, and desmin was present in mesothelial cells of serosa, pleura and pericardium, in stroma of umbilical cord and placental villi, in muscle cells of small intestine, tongue, and heart, and in muscle cells of blood vessels of lung, heart, umbilical cord, and placental villi. Mesothelium and reactive submesothelial stroma cells also coexpressed three classes of intermediate filament polypeptides. In some cases, immunoperoxidase results were confirmed by double labeling immunofluorescence microscopy or by immunoblotting experiments. The results of this study indicate that coexpression of different types of intermediate filaments is a more general phenomenon in fetal tissues than previously realized and it also occurs in some reactive proliferative lesions in the adult.
Clock Gene Expression Levels and Relationship With Clinical and Pathological Features in Colorectal Cancer Patients (2011)

The clock gene machinery controls cellular metabolism, proliferation, and key functions, such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved in tumorigenesis, and altered expression of some clock genes has been found in cancer patients. The aim of this study was to evaluate the expression levels of core clock genes in colorectal cancer (CRC). Quantitative real-time polymerase chain reaction (qPCR) was used to examine ARNTL1, CLOCK, PER1, PER2, PER3, CRY1, CRY2, Timeless (TIM), TIPIN, and CSNK1? expression levels in the tumor tissue and matched apparently healthy mucosa of CRC patients. In the tumor tissue of CRC patients, compared to their matched healthy mucosa, expression levels of ARNTL1 (p=.002), PER1 (p=.002), PER2 (p=.011), PER3 (p=.003), and CRY2 (p=.012) were lower, whereas the expression level of TIM (p=.044) was higher. No significant difference was observed in the expression levels of CLOCK (p=.778), CRY1 (p=.600), CSNK1 (p=.903), and TIPIN (p=.136). As to the clinical and pathological features, a significant association was found between low CRY1 expression levels in tumor mucosa and age (p=.026), and female sex (p=.005), whereas high CRY1 expression levels in tumor mucosa were associated with cancer location in the distal colon (p?=?.015). Moreover, high TIM mRNA levels in the tumor mucosa were prevalent whenever proximal lymph nodes were involved (p= .013) and associated with TNM stages III-IV (p=.005) and microsatellite instability (p=.015). Significantly poorer survival rates were evidenced for CRC patients with lower expression in the tumor tissue of PER1 (p=.010), PER3 (p= .010), and CSNKIE (p=.024). In conclusion, abnormal expression levels of core clock genes in CRC tissue may be related to the process of tumorigenesis and exert an influence on host/tumor interactions.