MECHANISMS, DIAGNOSIS AND TREATMENT OF HYPERTENSION OF RENAL VASCULAR ORIGIN (1959)

Article1 August 1959MECHANISMS, DIAGNOSIS AND TREATMENT OF HYPERTENSION OF RENAL VASCULAR ORIGINIRVINE H. PAGE, M.D., F.A.C.P., HARRIET P. DUSTAN, M.D., EUGENE F. POUTASSE, M.D.IRVINE H. PAGE, M.D., F.A.C.P., HARRIET P. DUSTAN, M.D., EUGENE F. POUTASSE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-196 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith Richard Bright's clinical observations, kidney disease and hypertension became indissolubly, though obscurely, associated; this association seemed to become more tangible when Goldblatt produced hypertension in the dog by putting a clamp on the renal artery. Although the relationship of the kidneys to hypertension was then more clearly defined, the mechanisms of this relationship have not yet been disclosed. Opinion in the last 25 years has ranged all the way from the one extreme, of believing that essential and malignant hypertension are due entirely to renal disease, to the other extreme, of denying all relationship. Like many extreme stands, these...Bibliography1. Page IH: Neural and humoral control of blood vessels, in Hypertension, humoral and neurogenic factors, edited by G. E. W. Wolstenholme and M. P. Cameron, 1954, J. & A. Churchill, London. CrossrefGoogle Scholar2. GrollmanMuirheadVanatta AEEJ: Role of the kidney in pathogenesis of hypertension as determined by a study of the effects of bilateral nephrectomy and other experimental procedures on the blood pressure of the dog, Am. J. Physiol. 157: 21, 1949. CrossrefMedlineGoogle Scholar3. KolffPage WJIH: Blood pressure reducing function of the kidney; reduction of renoprival hypertension by kidney perfusion, Am. J. Physiol. 178: 75, 1954. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Received for publication May 4, 1959.Presented at Clinical Session B at the Fortieth Annual Session of The American College of Physicians, Chicago, Illinois, April 21, 1959.From the Research Division and the Department of Urology of the Cleveland Clinic Foundation, Cleveland, Ohio.Requests for reprints should be addressed to the Research Division, Cleveland Clinic, 2020 East Ninety-third Street, Cleveland 6, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnhanced fractional sodium reabsorption in the ischaemic kidney revisited with lithium as a probeRenovascular hypertensionRegulation of arterial blood pressure by aortic baroreceptors in the unanesthetized dog.Stimulated Renin: A Screening Test for HypertensionLAWRENCE WALLACH, M.D., ILDIKO NYARAI, KEITH G. DAWSON, M.D., Ph.D., F.A.C.P., F.R.C.P. 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CONNOR, M.D., WILLIAM C. THOMAS JR., M.D., LILLIAN HADDOCK, M.D., JOHN EAGER HOWARD, M.D. 1 August 1959Volume 51, Issue 2Page: 196-211KeywordsAtherosclerosisHypertensionKidneysLesionsProteinsRenal arteriesRenal diseasesUrology ePublished: 1 December 2008 Issue Published: 1 August 1959 PDF downloadLoading ...