gebhart/patrepeval huggingface dataset:
SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells (2000)

In a previous study of nine human breast-derived cell lines, rates of metabolism of 17beta-estradiol (E(2)) were greatly enhanced when cultures were exposed to the aromatic hydrocarbon receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin. Elevated rates of E(2) hydroxylation at the C-2, -4, -6alpha and -15alpha positions were observed concomitant with the induction of cytochromes P450 1A1 and 1B1. In each cell line, 2- and 4-hydroxyestradiol (2- and 4-OHE(2)) were converted to 2- and 4-methoxyestradiol (2- and 4-MeOE(2)) by the action of catechol O:-methyltransferase. In this study, conjugation of these estrogen metabolites was investigated. A comparison of the levels of metabolites determined with and without prior treatment of the media with a crude beta-glucuronidase/sulfatase preparation showed that most of the 2-MeOE(2) present was in conjugated form, whereas 4-MeOE(2), 6alpha-OHE(2) and 15alpha-OHE(2) were minimally conjugated. Inhibitor studies suggested that it was the sulfatase activity of the preparation that hydrolyzed the 2-MeOE(2) conjugates in MCF-7 cell media; the presence of 2-MeOE(2)-3-sulfate in MCF-7 culture media was confirmed by electrospray ion-trap mass spectrometry. To identify the enzyme catalyzing this conjugation, the expression of mRNAs encoding five sulfotransferases (SULT1A1, SULT1A2, SULT1A3, SULT1E1 and SULT2A1) was evaluated in the nine cell lines by use of the reverse transcription-polymerase chain reaction. Only expression of SULT1A1 mRNA correlated with the observed conjugation of nanomolar levels of 2-MeOE(2) in these cell lines. Cloning and sequencing of SULT1A1 cDNA from MCF-7 cells revealed that mRNAs encoding two previously identified allelic variants, SULT1A1*1 ((213)Arg) and SULT1A1*2 ((213)His), were expressed in these cells. Heterologous cDNA-directed expression of either variant in MDA-MB-231 cells, which do not normally express SULT1A1, conferred 2-MeOE(2) sulfonation activity. The SULT1A1 allelic variants were also expressed in SF:9 insect cells, from which post-microsomal supernatants were used to determine K:(m) values of 0.90 +/- 0.12 and 0.81 +/- 0.06 microM for SULT1A1*1 and SULT1A1*2, respectively, with 2-MeOE(2) as substrate. These results show that SULT1A1 is an efficient and selective catalyst of 2-MeOE(2) sulfonation and, as such, may be important in modulating the anticarcinogenic effects of 2-MeOE(2) that have been described recently.
Large area selective emitters/absorbers based on 2D tantalum photonic crystals for high-temperature energy applications (2013)

We report highly selective emitters based on high-aspect ratio 2D photonic crystals (PhCs) fabricated on large area (2 inch diameter) polycrystalline tantalum substrates, suitable for high-temperature operation. As an example we present an optimized design for a selective emitter with a cut-off wavelength of 2μm, matched to the bandgap of an InGaAs PV cell, achieving a predicted spectral selectivity of 56.6% at 1200K. We present a fabrication route for these tantalum PhCs, based on standard microfabrication processes including deep reactive ion etch of tantalum by an SF6 based Bosch process, achieving high-aspect ratio cavities (&lt; 8:1). Interference lithography was used to facilitate large area fabrication, maintaining both fabrication precision and uniformity, with a cavity diameter variation of less than 2% across the substrate. The fabricated tantalum PhCs exhibit strong enhancement of the emittance at wavelengths below cut-off wavelength, approaching that of blackbody, and a steep cut-off between high and low emittance spectral regions. Moreover, detailed simulations and numerical modeling show excellent agreement with experimental results. In addition, we propose a surface protective coating, which acts as a thermal barrier coating and diffusion inhibitor, and its conformal fabrication by atomic layer deposition.
ALAS1gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice (2012)

Porphyrias are diseases caused by partial deficiencies of haem biosynthesis enzymes. Acute porphyrias are characterized by a neuropsychiatric syndrome with intermittent induction of hepatic ALAS1 (δ-aminolaevulinate synthase 1), the first and rate-limiting enzyme of the haem pathway. Acute porphyria attacks are usually treated by the administration of glucose; its effect is apparently related to its ability to inhibit ALAS1 by modulating insulin plasma levels. It has been shown that insulin blunts hepatocyte ALAS1 induction, by disrupting the interaction of FOXO1 (forkhead box O1) and PGC-1α (peroxisome-proliferator-activated receptor γ co-activator 1α). We evaluated the expression of ALAS1 in a murine model of diabetes and determined the effects of the insulinomimetic vanadate on the enzyme regulation to evaluate its potential for the treatment of acute porphyria attacks. Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1α and FOXO1-PGC-1α complex levels. Vanadate reversed ALAS1 induction, with a concomitant PI3K (phosphoinositide 3-kinase)/Akt pathway activation and subsequent reduction of nuclear FOXO1, PGC-1α and FOXO1-PGC-1α complex levels. These findings support the notion that the FOXO1-PGC-1α complex is involved in the control of ALAS1 expression and suggest further that a vanadate-based therapy could be beneficial for the treatment of acute porphyria attacks.
Samarium(III) formate (2006)

The title compound, poly[samarium(III)-tri-μ-formato], [Sm(HCO2)3]n, is isostructural with numerous lanthanide formates and comprises a three-dimensional framework assembled from SmO9 polyhedra and HCO2− anions. The Sm atom lies on a site of 3m symmetry and is coordinated by nine O atoms in a typical coordination geometry. The formate anions lie on mirror planes.
Orientation of tendons in the magnetic field and its effect on T2 relaxation times. (1985)

In vitro studies of spin-spin relaxation times of the protons or hydrogen nuclei which make up the tendon demonstrated significant dependence of T2 on orientation at physiological levels of hydration. T2 varied from approximately 250 mu sec. with the tendon aligned with the magnetic field to 22 msec. at an angle of 55 degrees or 125 degrees and 4 msec. at deviations of +/- 15 degrees from 55 degrees and 125 degrees. 55 degrees and 125 degrees are the so-called "magic angles" at which 3 cos2 theta - 1 = 0. As a result, the signal from human tendons in vivo will depend on their orientation; however, T2 is generally short enough that the signal intensity will approach 0 in MR images regardless of the orientation of the tendons, thereby preventing this phenomenon from being observed in most studies.
Telomeres, stem cells, senescence, and cancer (2004)

Mammalian aging occurs in part because of a decline in the restorative capacity of tissue stem cells. These self-renewing cells are rendered malignant by a small number of oncogenic mutations, and overlapping tumor suppressor mechanisms (e.g., p16(INK4a)-Rb, ARF-p53, and the telomere) have evolved to ward against this possibility. These beneficial antitumor pathways, however, appear also to limit the stem cell life span, thereby contributing to aging.
Detection of prostate-specific membrane antigen expressing cells in blood obtained from renal cancer patients: a potential biomarker of vascular invasion. (2000)

Originally, prostate-specific membrane antigen (PSMA) was described in benign and malignant prostate cells. On the basis of recent reports that this antigen also is expressed in normal renal proximal tubular cells and in the neovascular endothelium associated with renal carcinoma, we used a nested reverse transcriptase-polymerase chain reaction assay to evaluate whether PSMA-expressing cells might be present in specimens of peripheral blood obtained from renal cancer patients, benign renal tumor patients, and healthy volunteers. Our reverse transcriptase-polymerase chain reaction PSMA assay had a sensitivity of detecting 1 lymph node prostate cancer (LNCaP) per 10(7) lymphocytes. None of the 20 non-renal cancer controls were positive for PSMA mRNA, whereas 11 of 50 patients (22%) with diagnosed renal cancer were positive. Despite a comparative increase of PSMA positivity with stage, no statistical correlation was found. However, 44% of PSMA-positive patients had tumor size greater than 12 cm, versus only 9% in patients negative for PSMA (P = .03), and 67% of positive PSMA patients were found to have vascular invasion versus only 16% of patients negative for PSMA (P = .006; odds ratio, 10.8). This preliminary study suggests the possibility that PSMA expression in peripheral blood might be a useful biomarker for detecting or monitoring the progression of renal cancer in patients.
Energy-aware system design for wireless multimedia (2004)

In this paper, we present various challenges that arise in the delivery and exchange of multimedia information to mobile devices. Specifically, we focus on techniques for maintaining QoS to end-user multimedia applications (e.g. video streaming, multimedia conferencing) while maximizing device lifetimes. In order to cope with the resource intensive nature of multimedia applications (in terms of computation, bandwidth and consequently power) and dynamic congestion levels in wireless networks, an end-to-end approach to QoS-aware power optimization is required. We discuss the trend towards such an integrated approach that couples the architectural, OS, middleware and application layers to achieve both user experience and device energy gains. We conclude with a discussion of tools for integrated system design and testing that will aid in rapid deployment of wireless multimedia.
Educación social en la Unión Europea (2014)

El proceso de convergencia europea nos afecta en muchos aspectos y obviamente la educacion social no puede quedar al margen. En este articulo se hace una revision de algunas cuestiones en referencia a las dificultades de conceptualizacion de la Educacion social en el contexto de la Union europeo y tambien en la formacion de los futuros profesionales en este ambito. Se proponen algunos elementos para reflexionar sobre el presente y el futuro de la Educacion social. Se ponen de manifiesto las dificultades con las que nos encontramos para un acercamiento tanto en la forma de entenderla como la formacion que se ofrece
<title>Adaptive coherent suppression of multiple wide-bandwidth RFI sources in SAR</title> (2004)

This paper is concerned with suppressing multiple wide-bandwidth radio frequency interference (RFI) sources in SAR systems. A coherent processing of passive radar (sniff) data is presented to diminish the effects of wide-bandwidth as well as narrow-bandwidth RFI sources in the active radar data that are collected by a SAR system. The approach is based on a two-dimensional adaptive filtering of the active SAR data using the passive sniff data as the reference signal. A similar mathematical (signal) model and processing is also utilized to suppress self-induced resonance (SIR) signals that are generated by the interaction of the radar-carrying platform and the transmitted radar signal. Results are shown using the Army Research Laboratory (ARL) low-frequency, ultra-wideband (UWB) imaging radar (Boom-SAR).
Demographics and epidemiology of allergic and nonallergic rhinitis. (2002)

Chronic rhinitis symptoms are among the most common problems presenting to physicians. When approaching this problem the diagnostic challenge is to determine the etiology, whether it is allergic, nonallergic, or perhaps an overlap of both conditions. Estimates of the prevalence of allergic rhinitis range from as low as 9% to as high as 42%. Although nonallergic rhinitis is a well-recognized diagnosis, its prevalence has not been studied definitively. If the assumption is made that approximately 20% of the U.S. population has allergic rhinitis, then 58 million people in the United States suffer from this diagnosis. Population survey results have estimated that 19 million Americans suffer from nonallergic rhinitis. Frequently, nonallergic rhinitis occurs in tandem with allergic disease and presents as mixed rhinitis. Because 44% of patients with allergic rhinitis may have concomitant nonallergic rhinitis, it is estimated that an additional 26 million people have a nonallergic component to their rhinitis (mixed rhinitis). Therefore, a total estimated 45 million people have either pure nonallergic rhinitis or mixed rhinitis. Because nonallergic rhinitis is common, it is important to differentiate this condition from rhinitis of allergic etiology. Once the diagnosis is established, an appropriate treatment plan tailored to a specific diagnosis can be optimally designed.
An Exhaustive Swarming Search Strategy based on Distributed Pheromone Maps (2007)

[Abstract] Swarms of Unmanned Air Vehicles (UAVs) are well suited to perform missions comprising a search stage where multiple entities must be located over a wide geographic area. Because of their decentralized control architecture, swarms are scalable, robust and adapt to environmental changes. Pheromone maps are a common coordination mechanism that emulates the foraging behavior of insects. Swarming agents use such a map to coordinate with each other and to guide their search. Most pheromone frameworks require an uninterrupted wireless network connection for every agent in the swarm. This is incompatible with real world applications were UAVs are link limited because of environmental factors or mission requirements. Furthermore, search heuristics based on pheromone gradients are susceptible to local minima and only offer statistical guaranty of coverage. In this paper, we present an exhaustive search strategy and its supporting distributed pheromone map scheme. This approach does not require any network infrastructure. It relies on agents exchanging pheromones in an ad-hoc fashion. Its optimal search heuristic guaranties coverage and finite search times. Through experimental data, we show how distributed maps compare favorably with centralized ones.
Effects of Arginine on Photostability and Thermal Stability of IgG1 Monoclonal Antibodies (2009)

This study demonstrates that arginine is a highly effective solvent additive which significantly reduces the light induced aggregation of four IgG1 type monoclonal antibodies (named as IMC-1A, IMC-1B, IMC-1C and IMC-1D) as measured by size exclusion chromatography. All experiments were performed in a phosphate buffer system containing either sodium chloride or arginine hydrochloride. The protein samples were exposed to light in a photo chamber according to ICH (International Conference on Harmonization) guidelines. Thermal unfolding transition temperature (T(m)) of IMC-1A as determined by differential scanning calorimetry (DSC) was significantly decreased ( approximately 3.3 degrees C) in the presence of arginine hydrochloride as compared to in sodium chloride. However, a noticeable increase in thermal stability was observed for IMC-1B, IMC-1C and IMC-1D in the presence of arginine hydrochloride. The photostability of all these molecules was significantly enhanced by arginine hydrochloride and both a direct and inverse correlation was observed between conformational stability and photostability. To our knowledge, this paper for the first time, demonstrates that arginine hydrochloride considerably reduces the light induced aggregation of monoclonal antibodies. Arginine hydrochloride is also known to increase protein solubility and its ability to extensively reduce light induced aggregation makes it a potential solvent additive for the formulation development of therapeutic proteins.
Agonistic and Antagonistic Variants of Ciliary Neurotrophic Factor (CNTF) Reveal Functional Differences between Membrane-bound and Soluble CNTF α-Receptor (1997)

Ciliary neurotrophic factor (CNTF) drives the sequential assembly of a receptor complex containing the ligand-specific alpha-receptor subunit (CNTFR) and the signal-transducing beta-subunits gp130 and leukemia inhibitory factor receptor-beta (LIFR). CNTFR can function in either membrane-bound or soluble forms. The membrane-bound form mediates the neuronal actions of CNTF, whereas the soluble form serves to confer cytokine responsiveness to non-neuronal cells expressing gp130 and LIFR. The objective of this work was to analyze whether the two receptor isoforms differ in their ability to interact functionally with CNTF and related proteins. Two new types of CNTF variants, characterized by weakened interactions with either CNTFR or both LIFR and gp130, were developed, and the biological activities of these and other mutants were determined in non-neuronal versus neuronal cells, as well as in non-neuronal cells transfected with an expression vector for CNTFR. Membrane anchoring of CNTFR was found to render the CNTF receptor complex relatively insensitive to changes in agonist affinity for either alpha- or beta-receptor subunits and to promote a more efficient interaction with a gp130-depleting antagonistic variant of CNTF. As a result of this phenomenon, which can be rationalized in terms of the multivalent nature of CNTF receptor interaction, CNTF variants display striking changes in receptor selectivity.
Synthesis and characterization of in situ Fe2O3-coated FeF3 cathode materials for rechargeable lithium batteries (2012)

Here, a novel architecture of a core–shell structured FeF3@Fe2O3 composite with particle size of 100–150 nm and tunable Fe2O3 content is synthesized by a simple heat treatment process utilizing FeF3 with fine network structure as precursor. The structure, morphology and electrochemical performance of the pristine FeF3 and the FeF3@Fe2O3 composites are studied by XRD, SEM, TEM and discharge–charge measurements. XRD results show that the Bragg peaks of the FeF3@Fe2O3 composites are well indexed to FeF3 and Fe2O3. SEM and TEM images reveal the core–shell structure of the composites. The comparison of the electrochemical performance between the pristine FeF3 and the FeF3@Fe2O3 composites reveals that the in situ Fe2O3 coating (even with small amount, 0.6–5.2 wt%) has great influence on the improvement of electrochemical performance.
Acid-Base Balance in Bacteremic Shock (1971)

Acid-base balance studies were carried out in 30 patients in bacteremic shock who had been classed as being in "refractory" shock. Three patterns were distinguished. Compensated metabolic acidosis was present in 11 patients with six survivals and five deaths. Eight patients demonstrated decompensated metabolic acidosis with only three survivals. The remaining 11 presented with respiratory alkalosis, with nine survivals. Hypocapnia was a singularly prominent feature in 20 of the 30 patients and was not a factor in the deaths. The pH proved inadequate as index of prognosis. Most of the patients died with pH in normal limits. There was no correlation between cardiac output and the acid-base derangement. Lactacidemia proved ominous, particularly when extensive therapy failed to alter the arterial level. The best prognosis was in the group with respiratory alkalosis.
Compensation of the Piezo-Hall Effect in Integrated Hall Sensors on (100)-Si (2007)

Silicon Hall sensors are known to suffer from a long-term drift in the magnetic sensitivity between 1% and 4%, depending on the degree of moisture in the mold compound of the package. This drift is mainly caused by changes of mechanical stress exerted by the plastic package onto the die. We present a system, which continuously measures the relevant stress components, estimates the sensitivity drift, and corrects for it digitally. An individual precalibration versus temperature is necessary to achieve the required level of accuracy. Results from laboratory characterization with pressure cells and lifetime drift during qualification runs show that this system can keep the drift of magnetic sensitivity well below 1%.
Treatment of Crohn's Disease with 6-Mercaptopurine (1980)

To test the effectiveness of 6-mercaptopurine (6-MP) in the treatment of Crohn's disease, we entered 83 chronically ill patients into a two-year double-blind study comparing 6-MP with placebo. Crossover data showed that improvement occurred in 26 of 39 courses of 6-MP (67%) as compared with three of 39 courses of placebo (8%) (P less than 0.001). Non-crossover data likewise confirmed the superiority of 6-MP. The drug was more effective than placebo in closing fistulas (31 vs 6%) and in permitting discontinuation or reduction of steroid dosage (75 vs. 36%) (P less than 0.001). The onset of response to 6-MP was often delayed, with 32% of patients taking longer than three months to respond, and 19% taking longer than four months. Adverse side effects to 6-MP occurred in 10% of patients and were uniformly reversible. We conclude that 6-MP is an effective and useful agent in the management of Crohn's disease.
CloudDRN: A Lightweight, End-to-End System for Sharing Distributed Research Data in the Cloud (2013)

The cloud has proven itself as a scalable platform for Web-based applications. However, scientists and medical researchers are still searching for a simple cloud-based architecture that enables secure collaboration and sharing of distributed datasets. To date, attempts at using the cloud for this purpose generally view the cloud as simply a pool of servers upon which to run their legacy software. This approach fails to leverage the unique platform capabilities of the cloud. In this paper, we describe our Cloud Distributed Research Network (CloudDRN). We leverage the cloud for availability, reliability, scalability, and improved security as compared to legacy distributed systems while still supporting site autonomy. Our philosophy is to adapt commercial software tooling that was originally designed for business use-cases, thereby benefiting from the large built-in user community. We describe our general architecture and show an example of our system created to share distributed clinical research data. We evaluate our system in Amazon Web Services (AWS) and in Microsoft Windows Azure and find that while each cloud achieves similar financial cost, representative queries are 3.5x slower on average in Windows Azure.
Expression of B1 kinin receptors mediating paw edema and Formalin-induced nociception. Modulation by glucocorticoids (1995)

Bradykinin (BK) and Tyr8-BK induced graded rat paw edema with EC50 values of 1.9 and 1.1 nmol/paw, while des-Arg9-BK (DABK, up to 300 nmol/paw) was marginally effective. Tyr8-BK, but not DABK, also caused a dose-related increase in mouse paw edema, with an EC50 of 1.3 nmol/paw. The response to Tyr8-BK (10 nmol/paw) in rat paw edema was antagonized by B2 receptor antagonists (HOE-140 or NPC 17731, 30 nmol/paw) but not by the B1 antagonist des-Arg9[Leu8]BK (DALBK, 100 nmol/paw). Daily intraplantar injections of Tyr8-BK (10 nmol/paw) for 7 days caused progressive desensitization (D) of edema in sham-operated and adrenalectomized Wistar rats. DABK (100 nmol/paw) caused marked paw edema in D paws from both groups, which was inhibited by DALBK (100 nmol/paw) and by dexamethasone (0.5mg/kg, s.c.). Systemic injection of lipopolysaccharide (10 micrograms/mouse, 24 h prior) potentiated the first and second phases of Formalin-induced pain but had no effect on paw edema. Coinjection of DABK (2-22 nmol/paw) with low doses of Formalin in lipopolysaccharide-treated mice, which had no effect on naive animals, dose dependently potentiated both phases of Formalin-induced pain but did not modify paw edema. These effects were antagonized by DALBK with ID50 values of 21.9 (first phase) and 64.1 (second phase) nmol/paw. Thus, both progressive desensitization of B2 receptors and systemic treatment with lipopolysaccharide induce a glucocorticoid-sensitive upregulation of B1 receptors mediating paw edema in the rat and Formalin-induced nociception in mice. These results suggest that induction of upregulation of B1 receptors may play important roles in controlling inflammatory processes and hyperalgesia.