gebhart/patrepeval huggingface dataset:
Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide. (1999)

A unique lymphoid lineage, Valpha14 NKT cells, bearing an invariant Ag receptor encoded by Valpha14 and Jalpha281 gene segments, play crucial roles in various immune responses, including protective immunity against malignant tumors. A specific ligand of Valpha14 NKT cells is determined to be alpha-galactosylceramide (alpha-GalCer) which is presented by the CD1d molecule. Here, we report that dendritic cells (DCs) pulsed with alpha-GalCer effectively induce potent antitumor cytotoxic activity by specific activation of Valpha14 NKT cells, resulting in the inhibition of tumor metastasis in vivo. Moreover, a complete inhibition of B16 melanoma metastasis in the liver was observed when alpha-GalCer-pulsed DCs were injected even 7 days after transfer of tumor cells to syngeneic mice where small but multiple metastatic nodules were already formed. The potential utility of DCs pulsed with alpha-GalCer for tumor immunotherapy is discussed.
Attractiveness of trans-Trimedlure and Its Four Isomers in Field Tests with the Mediterranean Fruit Fly (Diptera: Tephritidae)1 (1987)

Journal Article Attractiveness of trans-Trimedlure and Its Four Isomers in Field Tests with the Mediterranean Fruit Fly (Diptera: Tephritidae) Get access T. P. McGovern, T. P. McGovern Agricultural Research Service, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar R. T. Cunningham, R. T. Cunningham Agricultural Research Service, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar B. A. Leonhardt B. A. Leonhardt Agricultural Research Service, U.S. Department of Agriculture Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 80, Issue 3, 1 June 1987, Pages 617–620, https://doi.org/10.1093/jee/80.3.617 Published: 01 June 1987 Article history Received: 07 July 1986 Accepted: 12 February 1987 Published: 01 June 1987
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3 (2000)

Treatment of human artery wall cells with apolipoprotein A-I (apoA-I), but not apoA-II, with an apoA-I peptide mimetic, or with high density lipoprotein (HDL), or paraoxonase, rendered the cells unable to oxidize low density lipoprotein (LDL). Human aortic wall cells were found to contain 12-lipoxygenase (12-LO) protein. Transfection of the cells with antisense to 12-LO (but not sense) eliminated the 12-LO protein and prevented LDL-induced monocyte chemotactic activity. Addition of 13( S )-hydroperoxyoctadecadienoic acid [13( S )-HPODE] and 15( S )-hydroperoxyeicosatetraenoic acid [15( S )-HPETE] dramatically enhanced the nonenzymatic oxidation of both 1-palmitoyl-2-arachidonoylsn -glycero-3-phosphocholine (PAPC) and cholesteryl linoleate. On a molar basis 13( S )-HPODE and 15( S )-HPETE were approximately two orders of magnitude greater in potency than hydrogen peroxide in causing the formation of biologically active oxidized phospholipids (m/z 594, 610, and 828) from PAPC. Purified paraoxonase inhibited the biologic activity of these oxidized phospholipids. HDL from 10 of 10 normolipidemic patients with coronary artery disease, who were neither diabetic nor receiving hypolipidemic medications, failed to inhibit LDL oxidation by artery wall cells and failed to inhibit the biologic activity of oxidized PAPC, whereas HDL from 10 of 10 age-and sex-matched control subjects did. We conclude that a ) mildly oxidized LDL is formed in three steps, one of which involves 12-LO and each of which can be inhibited by normal HDL, and b ) HDL from at least some coronary artery disease patients with normal blood lipid levels is defective both in its ability to prevent LDL oxidation by artery wall cells and in its ability to inhibit the biologic activity of oxidized PAPC. -
Physical One-Way Functions (2002)

Modern cryptographic practice rests on the use of one-way functions, which are easy to evaluate but difficult to invert. Unfortunately, commonly used one-way functions are either based on unproven conjectures or have known vulnerabilities. We show that instead of relying on number theory, the mesoscopic physics of coherent transport through a disordered medium can be used to allocate and authenticate unique identifiers by physically reducing the medium's microstructure to a fixed-length string of binary digits. These physical one-way functions are inexpensive to fabricate, prohibitively difficult to duplicate, admit no compact mathematical representation, and are intrinsically tamper-resistant. We provide an authentication protocol based on the enormous address space that is a principal characteristic of physical one-way functions.
Videotex Services: Network and Terminal Alternatives (1979)

Videotex has provisionally become the generic name for interactive systems offering visual information services using a suitably modified or augmented home TV set, telephone and/or data networks, and videotex service centres. This paper starts by briefly introducing the videotex system concept and service possibilities. Examples of existing systems are also given. The main body of the paper considers two areas where new technology has a key role in videotex: in the network of service centres and communications facilities, and in the terminals, both at the information provider's end and at the consumer's end.. The trade-offs between multiple-format databases, source coding, terminal complexity and compatibility are examined. The possible solutions to terminal design range from a single, rigid design to an arbitrary combination method. The paper proposes a Layered Capability Structure (LCS) which promotes an evolutionary approach to terminal design.
Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta (1984)

Human chorionic gonadotropin (hCG) is a placental hormone essential for the maintenance of pregnancy. While the alpha subunit of this hormone is encoded by a single gene, the beta subunit is encoded by a complex family of seven very similar genes or pseudogenes. Two approaches have been taken to establish which of these genes are functional. First, we have used two restriction enzyme site polymorphisms to correlate 15 independently isolated beta hCG cDNA clones with their corresponding genes. Second, we have used transient expression in COS cells to assay for correctly-initiated transcription from six of the seven beta hCG gene promoters. From these data, we conclude that, at most, only three of the seven beta hCG genes are expressed in the placenta. Comparison of the sequences of a functional and a non-functional beta hCG gene reveals no obvious differences, such as promoter changes, that could account for this differential expression.
Structure and Heterogeneity of Antibodies (1966)

Review Articles| March 17 2009 Structure and Heterogeneity of Antibodies Subject Area: Hematology , Oncology E.A. Kabat E.A. Kabat Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, Neurological Institute, Presbyterian Hospital, New York, N. Y. Search for other works by this author on: This Site PubMed Google Scholar Acta Haematol (1966) 36 (3-4): 198–238. https://doi.org/10.1159/000209100 Article history Published Online: March 17 2009 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation E.A. Kabat; Structure and Heterogeneity of Antibodies. Acta Haematol 31 December 1966; 36 (3-4): 198–238. https://doi.org/10.1159/000209100 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Haematologica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
DEATH BY DISTRACTION (2000)

In-vehicle telematics will soon include email, beepers and the Internet. Automakers claim it will be safe, but safety experts say it could prove deadly
Implementation of early monitor by advanced ebeam metrology for charging damage failure mechanism (2011)

Based on failure analysis data the estimated failure mechanism in capacitor like device structures was created on wafer in Front End of Line. In the study the optimal process step for electron beam inspection (EBI) on Hermes Microvision eScanlite system was identified within various process steps. Finally an electron beam inspection monitor for early warning was established specifically to identify this fail mechanism with ADC (Automated Defect Classification) and statistical process control.
Buspirone treatment of sexual dysfunction associated with selective serotonin re‐uptake inhibitors (1994)

Abstract A retrospective study was done of sixteen patients treated with adjunctive buspirone in the context of sexual dysfunction associated with the use of selective serotonin re‐uptake inhibitors (SSRls). Sexual functioning was rated as much or very much improved in 11 patients (69%). Treatment was generally very well tolerated. However, several patients who had become less irritable after treatment with an SSRI, reported increased irritability. The results suggest adjunctive buspirone may be useful in the management of sexual dysfunction associated with SSRIs; possible mechanisms of action are discussed. Depression 2:109–112 (1994). © 1994 Wiley‐Liss, Inc.
The Effect of Apolipoprotein A-II on the Structure and Function of Apolipoprotein A-I in a Homogeneous Reconstituted High Density Lipoprotein Particle (1997)

In this study we examined the effects of apoA-II on the structure and function of apoA-I in homogeneous reconstituted HDL (rHDL). First, we measured the binding of apoA-II to apoA-I-rHDL, containing dipalmitoylphosphatidylcholine or palmitoyloleoylphosphatidylcholine, and the degree of apoA-I displacement at various ratios of apolipoproteins. Using fluorescence methods, we determined that apoA-II binding is rapid, irreversible, and associated with apoA-I displacement only when the molar ratio of apoA-II/apoA-I is greater than 1:2. Next, we used the stable apoA-II/apoA-I-rHDL complex at the apoA-II/apoA-I ratio of 1:2 to examine its physical properties, apoA-I structure, and reactivity with lecithin:cholesterol acyltransferase (LCAT). Using chemical cross-linking in conjunction with fluorescence and electrophoretic methods, we demonstrated that the conformation of apoA-I must be flexible to allow apoA-II binding to the apoA-I-rHDL particles and showed that the hybrid particles have an unchanged Stokes diameter. Fluorescence and circular dichroism measurements revealed little or no change in the secondary structure or in the N-terminal domain of apoA-I, but showed a marked destabilization of apoA-I to denaturation by guanidine hydrochloride. Limited tryptic digestion indicated that the central region of apoA-I becomes accessible to proteolysis in the hybrid particles. Together, these results suggest that amphipathic alpha-helices of apoA-II replace four central helices of one apoA-I molecule (residues approximately 99-187) in the complex and in the process destabilize apoA-I. Thus, apoA-II binding at physiologic ratios may not completely displace apoA-I from HDL, but may provide a reservoir of easily exchangeable apoA-I. Finally, we showed that the reaction of the hybrid HDL with LCAT was inhibited 2-5-fold, relative to apoA-I-rHDL, due to a corresponding increase in the apparent Km value. This suggests that LCAT binding to the hybrid particles is sterically hindered by the excess protein (portions of apoA-I and apoA-II not bound to lipid). Therefore, apoA-II can modulate the reaction of HDL with LCAT by decreasing LCAT binding to hybrid particles and making the enzyme available for reaction with other substrates.
Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. (1992)

Infection by certain human papillomavirus types is regarded as the major risk factor in the development of cervical cancer, one of the most common cancers of women worldwide. Analysis of the immunogenic and structural features of papillomavirus virions has been hampered by the inability to efficiently propagate the viruses in cultured cells. For instance, it has not been established whether the major capsid protein L1 alone is sufficient for virus particle assembly. In addition, it is not known whether L1, L2 (the minor capsid protein), or both present the immunodominant epitopes required for induction of high-titer neutralizing antibodies. We have expressed the L1 major capsid proteins of bovine papillomavirus type 1 and human papillomavirus type 16 in insect cells via a baculovirus vector and analyzed their conformation and immunogenicity. The L1 proteins were expressed at high levels and assembled into structures that closely resembled papillomavirus virions. The self-assembled bovine papillomavirus L1, in contrast to L1 extracted from recombinant bacteria or denatured virions, also mimicked intact bovine papillomavirus virions in being able to induce high-titer neutralizing rabbit antisera. These results indicate that L1 protein has the intrinsic capacity to assemble into empty capsid-like structures whose immunogenicity is similar to infectious virions. This type of L1 preparation might be considered as a candidate for a serological test to measure antibodies to conformational virion epitopes and for a vaccine to prevent papillomavirus infection.
Cervical Epidermal Growth Factor‐Receptor (EGF‐R) and Serum Insulin‐Like Growth Factor II (IGF‐II) Levels are Potential Markers for Cervical Cancer1 (2000)

Cervical epithelial EGF-R and serum IGF-II levels may be used for the diagnosis and prognosis of cervical cancer.
DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor. (1980)

The nonspecific DNA binding capacity of repressor protein has been assessed by boundary sedimentation of repressor and calf thymus DNA fragmented by shearing and by nitrocellulose ultrafiltration employing labeled lambdaplac DNA in the presence of inducer concentrations sufficient to insure dissociation of repressor from the operator region of the DNA. These methods gave values in good agreement with values previously reported in the literature. The association constants for the interaction of repressor with operator DNA fragments and lambdaplac DNA have been measured and found to differ by approximately 100-fold at low salt concentrations, but the difference decreases to 4-fold at salt concentrations near the physiological value. The equilibrium association constant for the repressor-operator DNA fragment is significantly less sensitive to salt concentration than the corresponding constant for lambdaplac DNA. Inducer decreases the salt concentration dependence of repressor-operator DNA fragment only slightly. Measurement of the association constants for the interaction of the trypsin-resistant core protein with operator DNA fragment and lambdaplac DNA indicate that the core protein binds to the two DNA's with the same affinity. This result contrasts with the differential affinity of intact repressor for these two DNA's. In addition, the core protein association constants for operator DNA fragment and lambdaplac DNA display minimal dependence on the salt concentration. These results suggest a role for nonionic interactions in the binding of core protein to operator DNA.
Composition, antibacterial, antioxidant and antiproliferative activities of essential oils from three Origanum species growing wild in Lebanon and Greece (2015)

The essential oils from Origanum dictamnus, Origanum libanoticum and Origanum microphyllum were analysed by GC-MS, finding carvacrol, p-cymene, linalool, γ-terpinene and terpinen-4-ol as major components. The antioxidant activity by the DPPH and FRAP tests and the antiproliferative activity against two human cancer cell lines, LoVo and HepG2, were investigated, showing that the essential oil of O. dictamnus was statistically the most inhibitory on both the cell lines, while all the oils exerted a weak antioxidant activity. Furthermore, the samples were tested against 10 Gram-negative and Gram-positive bacteria; all the oils were active on Gram-positive bacteria but O. dictamnus essential oil was the most effective (MIC = 25-50 μg/mL), showing also a good activity against the Gram-negative Escherichia coli (MIC = 50 μg/mL). Data suggest that these essential oils and particularly O. dictamnus oil could be used as valuable new flavours with functional properties for food or nutraceutical products.
Perturbations in B cell responsiveness to CD4+T cell help in HIV-infected individuals (2003)

HIV infection induces a wide array of B cell dysfunctions. We have characterized the effect of plasma viremia on the responsiveness of B cells to CD4(+) T cell help in HIV-infected patients. In HIV-negative donors, B cell proliferation correlated with CD154 expression on activated CD4(+) T cells and with the availability of IL-2, whereas in HIV-infected viremic patients, reduced B cell proliferation was observed despite normal CD154 expression on activated CD4(+) T cells. Reduced triggering of B cells by activated CD4(+) T cells was clearly observed in HIV-infected viremic patients compared with aviremic patients with comparable CD4(+) T cell counts, and a dramatic improvement in B cell function was observed in patients whose plasma viremia was controlled by effective antiretroviral therapy. The degree of B cell dysfunction in viremic patients correlated strongly with the inability of B cells to express CD25 in response to activated CD4(+) T cells, resulting in an inability to mount a normal proliferative response to IL-2. Similar defects in responsiveness to IL-2 were observed in the B cells of HIV-infected viremic patients in the context of B cell receptor stimulation. These data provide new insight into the mechanisms associated with ineffective humoral responses in HIV disease.
An Introduction to Stem Cell Biology (2010)

The field of stem cell biology has undergone tremendous expansion over the past two decades. Scientific investigation has continued to expand our understanding of these complex cells at a rapidly increasing rate. This understanding has produced a vast array of potential clinical applications. This article will serve as an overview of the current state of stem cell research as it applies to scientific and medical applications. Included in the discussion is a review of the many different types of stem cells, including but not limited to adult, embryonic, and perinatal stem cells. Also, this article describes somatic cell nuclear transfer, an exciting technology that allows the production of totipotent stem cells from fully differentiated cells, thereby eliminating the use of embryonic sources. This discussion should serve as a review of the field of stem cell biology and provide a foundation for the reader to better understand the interface of stem cell technology and facial plastic and reconstructive surgery.
Dual Control by Divalent Cations and Mitogenic Cytokines of α4β1 and α5β1 Integrin Avidity Expressed by Human Hemopoietic Cells (1998)

Beta-1 integrins have essential functions in hemopoietic and immune systems by controlling phenomenons such as cell homing and cell activation. The function alpha 4 beta 1 and alpha 5 beta 1 integrins is regulated by divalent cations and, as demonstrated more recently, by mitogenic cytokines which activate them by "inside-out" mechanisms. Using the adhesive interaction of a cytokine-dependent human hemopoietic cell line to immobilized fibronectin, we have analyzed the requirements in divalent cations Mn2+, Mg2+ and Ca2+ for alpha 4 beta 1 and alpha 5 beta 1 activation by "inside-out" mechanisms triggered by cytokines such as granulocyte-macrophage colony stimulating factor or KIT ligand, or by external conformational constraints with the function-activating anti-beta 1 integrin monoclonal antibody 8A2. The intrinsic difference between these two modes of beta 1 integrin activation was revealed by their different requirements in divalent cations. We found that in the absence of any divalent cations, alpha 4 beta 1 and alpha 5 beta 1 were non-functional even after further stimulation by cytokines or 8A2. However, whilst either Ca2+, Mg2+ or Mn2+ were able to restore adhesive functions of alpha 4 beta 1 and alpha 5 beta 1 when activated by 8A2, only Mg2+ and Mn2+ were able to support activation of alpha 4 beta 1 and alpha 5 beta 1 by cytokines. Furthermore, high concentrations of Ca2+ exceeding 20 mM dramatically inhibited cell adhesion to fibronectin induced by Mn2+ and cytokines but not by 8A2. On the contrary, in the presence of both Ca2+ and Mg2+, Mn2+ had an additive effect on the activation of alpha 4 beta 1 and alpha 5 beta 1 by mitogenic cytokines. The presence of the absence of these divalent cations did not inhibit early tyrosine phosphorylation induced by the binding of KIT ligand to its tyrosine-kinase receptor KIT. Therefore, we propose that in hemopoietic cells, Ca2+, Mg2+ and Mn2+ may modulate in vivo alpha 4 beta 1 and alpha 5 beta 1 regulation by mitogenic cytokines, a phenomenon involved in the regulation of hemopoietic progenitor cell homing within the bone marrow.
Libckpt: transparent checkpointing under Unix (1995)

Checkpointing is a simple technique for rollback recovery: the state of an executing program is periodically saved to a disk file from whichitcan be recovered after a failure. While recent research has developed a collection of powerful techniques for minimizing the overhead of writing checkpoint files, checkpointing remains unavailable to most application developers. In this paper we describe libckpt, a portable checkpointing tool for Unix that implements all applicable performance optimizations which are reported in the literature. While libckpt can be used in a mode whichis almost totally transparent to the programmer, it also supports the incorporation of user directives into the creation of checkpoints. This user-directed checkpointing is an innovation which is unique to our work.