gebhart/patrepeval huggingface dataset:
Genetic restriction of autoreactive acetylcholine receptor-specific T lymphocytes in myasthenia gravis. (1985)

Human autoreactive helper T lymphocytes with specificity for acetylcholine receptor (AChR) were isolated from three HLA-DR3-positive patients who had myasthenia gravis (MG), an autoimmune disease known to be associated with HLA-DR3 in the North European population. The antigen-specific T cells were evaluated for genetic restriction. Antigen presentation studies were performed with mitomycin C-treated accessory cells from a panel of HLA-typed unrelated donors. AChR-induced proliferation of the autoreactive T cells was maximal in the presence of autologous or HLA-DR-compatible antigen-presenting cells. In two DR-heterozygous patients both parental DR specificities served as restriction elements of the polyclonal AChR-reactive T cell populations. Preferential restriction to HLA-DR3 was observed in one patient, but this was also seen with PPD-specific T cells from the same donor. A series of monoclonal antibodies against HLA class II molecules was used for inhibition experiments. The inhibitory effects of the antibodies were not due to unspecific toxicity and could be observed after separate treatment of the antigen-presenting cells but not of the responding T cells. Several monoclonal antibodies against monomorphic HLA-DR determinants (DA 231, MAS 53, MAS 54, L243, OKIa1) had pronounced inhibitory effects. Anti-HLA-DQ(DC) monoclonal antibodies (Leu-10; TU 22) had only mild or no inhibitory effects in two patients but significantly inhibited AChR-specific T cells in one patient. A monoclonal antibody against HLA-DR3 (antibody 16.23) was not or was only weakly inhibitory in the DR3-positive patients, although it bound to autologous T line cells and B cells by indirect immunofluorescence. In one patient it was possible to compare the inhibition patterns of AChR-specific and PPD-specific T cells. Most of the monoclonal antibodies affected AChR- and PPD-specific T cells to a similar extent, but three antibodies (TU 22, 36, 39) inhibited PPD-specific T cells more than AChR-specific T cells, indicating the possibility of differential restriction of antigen- and autoantigen-specific T cells. It is suggested that the in vitro system described here may be helpful for the evaluation of anti-HLA class II antibodies as potential immunotherapeutic reagents.
Estimating local mean signal strength of indoor multipath propagation (1997)

We explore techniques for the measurement of local mean signal strength at 900 MHz and 2 GHz. In particular, we characterize the impact of transmitter and receiver antenna rotation on the estimated local mean. Then, we explore the collection of high resolution data while moving along a linear trajectory and using linear averaging techniques to estimate the local mean. With this information, the best measurement techniques can be chosen depending on the required speed versus accuracy tradeoff. Finally, we use a ray tracing propagation model to evaluate different methods of calculating the local mean signal strength for indoor environments.
Wash‐in rate on the basis of dynamic contrast‐enhanced MRI: Usefulness for prostate cancer detection and localization (2005)

The wash-in rate based on DCE-MRI is a useful parameter for prostate cancer detection and localization.
Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice (2009)

Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.
Cruciferous Plants: Phytochemical Toxicity Versus Cancer Chemoprotection (2009)

The Cruciferae (also known as the Brassicaceae) are the family of plants that include the various familiar members of the species Brassica oleracea (e.g., broccoli, cabbage, cauliflower, kale, Brussels sprouts) as well as many other plants that are widely consumed in various parts of the world. Forage and root brassicas are widely used as winter feeds for cattle and sheep. A striking and characteristic chemical property of cruciferous plants is their high content of glucosinolates (more than 120 types), which often approaches 1% or more of their dry weight. The interest devoted to this group of natural products is caused by the appreciable biological effects of both the intact glucosinolates (GSLs) and especially the complex group of glucosinolate transformation products produced in non-enzymatic and enzymatic reactions. Depending on the concentration and structural types of these compounds, their biological effects can be toxic, anti-nutritional or beneficial to health. Most serious economic problems in livestock seem to result from rapeseed meal; arising from GSLs or their breakdown products. In contrast, GSLs and their isothiocyanate (ITC) hydrolysis products are reportedly well-known protectors against carcinogenesis. GSLs play further protective and evolutionarily important roles in plants. These include allelopathy (suppression of growth of neighboring plants), specific positive and negative feeding cues for some insects and broad antibiotic properties including nematocidal, antimicrobial, antifungal, antiprotozoal and insecticidal activities. The controversy in the referred actions contributed to crucifers' phytochemicals has been exclusively discussed.
Adaptive system correction for robust Fourier ptychographic imaging (2013)

Fourier ptychography (FP) is a recently developed imaging approach that bypasses the resolution limit defined by the lens' aperture. In current FP imaging platforms, systematic noise sources come from the intensity fluctuation of multiple LED elements and the pupil aberrations of the employed optics. These system uncertainties can significantly degrade the reconstruction quality and limit the achievable resolution, imposing a restriction on the effectiveness of the FP approach. In this paper, we report an optimization procedure that performs adaptive system correction for Fourier ptychographic imaging. Similar to the techniques used in phase retrieval, the reported procedure involves the evaluation of an image-quality metric at each iteration step, followed by the estimation of an improved system correction. This optimization process is repeated until the image-quality metric is maximized. As a demonstration, we used this process to correct for illumination intensity fluctuation, to compensate for pupil aberration of the optics, and to recover several unknown system parameters. The reported adaptive correction scheme may improve the robustness of Fourier ptychographic imaging by factoring out system imperfections and uncertainties.
A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems (2008)

Doses of 0.37-2.21 mg kg(-1) of CNS 7056 produced sedation for 9-25 min without excessive respiratory or cardiovascular depression, and would be suitable for pharmacokinetic studies. The power in the alpha band of the EEG can be used as a continuous measure of the sedative effects of CNS 7056.
Liquid Cooling of Tractive Lithium Ion Batteries Pack with Nanofluids Coolant (2014)

The heat generated from tractive lithium ion batteries during discharge-charge process has great impacts on the performances of tractive lithium ion batteries pack. How to solve the thermal abuse in tractive lithium ion batteries pack becomes more and more urgent and important for future development of electrical vehicles. In this work, TiO2, ZnO and diamond nanofluids are prepared and utilized as coolants in indirect liquid cooling of tractive lithium ion batteries pack. The results show that nanofluids present superior cooling performance to that of pure fluids and the diamond nanofluid presents relatively excellent cooling abilities than that of TiO2 and ZnO nanofluids. During discharge process, the temperature distribution of batteries in batteries pack is uniform and stable, due to steady heat dissipation by indirect liquid cooling. It is expected that nanofluids could be considered as a potential alternative for indirect liquid cooling in electrical vehicles.
Atomic Layer Deposition of Rhenium–Aluminum Oxide Thin Films and ReOx Incorporation in a Metal–Organic Framework (2017)

Methyltrioxorhenium (ReO<sub>3</sub>Me) is introduced as the first rhenium atomic layer deposition (ALD) precursor and used to grow rhenium-aluminum oxide thin films in combination with trimethylaluminum (TMA-AlMe<sub>3</sub>). The growth rate of the smooth Re-Al oxide films, with general stoichiometry Re<sub>x</sub>Al<sub>y</sub>O<sub>3x</sub>, has been monitored by in situ quartz crystal microbalance (QCM) and ex situ ellipsometry, and found to be 3.2 Å/cycle. X-ray photoelectron spectroscopy (XPS) revealed the mixed valent composition of the film with Re(III) species being the main component. In addition, ReO<sub>3</sub>Me has been successfully used to deposit rhenium oxide in NU-1000, a mesoporous zirconium-based metal-organic framework (MOF). The metalated MOF was found to retain porosity and crystallinity and to be catalytically active for ethene hydrogenation.
EPIZOOTIOLOGY OF BLUETONGUE: THE SITUATION IN THE UNITED STATES OF AMERICA (1975)

Bluetongue was first reported in the United States in 1948 in sheep in Texas. The virus has now been isolated from sheep in 19 States. When the disease first occurs in a flock, the morbidity may reach 50 to 75% and mortality 20 to 50%. In subsequent years, the morbidity may be only 1 to 2% with very few deaths. Difference in breed susceptibility has not been observed. Natural bluetongue infection has not been observed in Angora or dairy goats. Bluetongue virus was first isolated from cattle, in Oregon, in 1959. The virus has now been isolated from cattle in 13 States. In cattle, the disease is usually inapparent but can cause mild to severe clinical disease and neonatal losses. Natural clinical bluetongue has also been reported in bighorn sheep, exotic ruminants in a zoo, mule deer, and white-tailed deer. Serological evidence of exposure to the virus has also been found in other species of ruminants in the wild. Inoculation of virulent bluetongue virus, vaccine virus, or natural disease can cause congenital deformities and neonatal losses in calves, lambs, and white-tailed deer fawns. Culicoides is considered the important insect vector of bluetongue. The virus has also been isolated from sheep keds and cattle lice. U.S. field strains of the virus fit into four serologic groups. No cross reactions were found between bluetongue and epizootic haemorrhagic disease of deer viruses. Cattle are considered significant virus reservoirs. It is necessary to use washed erythrocytes, rather than whole blood, and to inoculate susceptible sheep, rather than embryonated chicken eggs, to detect longer-term viraemia in cattle.
A phase 1b study of the anticancer stem cell agent demcizumab (DEM) and gemcitabine (GEM) with or without paclitaxel protein bound particles (nab-paclitaxel) in patients with pancreatic cancer. (2014)

279 Background: Delta-like ligand 4 (DLL4) is a ligand that activates the Notch pathway. DEM is a humanized IgG 2 anti-DLL4 antibody that inhibits tumor growth and decreases cancer stem cell (CSC) frequency in minimally passaged human xenograft models. In addition, DEM has been shown to have an antiangiogenic effect and showed synergistic activity when combined with GEM and nab-paclitaxel in human pancreatic tumor-derived xenograft models. Methods: Pts with 1 st line stage pancreatic cancer received DEM (2.5 every 2 or 4 wks or 5 mg/kg every 4 wks) and GEM 1000 mg/m 2 7 of 8 wks, then 3 of every 4 wks. The primary objective was to determine the MTD of DEM. Other objectives were safety, efficacy, immunogenicity, PK and biomarkers of Notch signaling and CSCs. Results: Twenty four pts were enrolled; 8 received 2.5 mg/kg every 2 wks, 8 received 2.5 mg/kg every 4 wks &amp; 8 received 5 mg/kg every 4 wks of DEM. Three (12.5%) and 21 (87.5%) pts had stage III and IV disease, respectively. Related AEs (all grades) in &gt; 15% of pts were: fatigue (29%), hypertension (29%), vomiting (29%), nausea (25%), thrombocytopenia (21%) and decreased appetite (21%). The hypertension was managed with oral anti-hypertensives. Increased BNP values appear to be an early indicator of the cardiac effects of DEM and mildly elevated values are being used to initiate cardioprotective therapy with an ACE inhibitor or carvedilol. One pt who received 5 mg/kg developed reversible pulmonary hypertension and heart failure on study day 143. As a result, the duration of DEM will be limited to 70 days in subsequent cohorts. Four of 16 (25%) pts had a RECIST partial response and 7 had stable disease. The median PFS for the 5 mg/kg cohort was 5.9 months. The PK and immunogenicity data will also be presented. Conclusions: DEM plus GEM were generally well tolerated with fatigue, hypertension, and vomiting being the most common drug related AEs. Encouraging early clinical activity was observed. The duration of DEM is being limited to 70 days and nab-paclitaxel is also being given in subsequent cohorts. The first cohort of pts receiving GEM, nab-paclitaxel, and DEM has been enrolled and &gt; 100 days of follow-up on these pts will be presented. Clinical trial information: NCT01189929.
Signaling Entropy Label Capability Using IS-IS (2015)

Multi Protocol Label Switching (MPLS) has defined a mechanism to load
balance traffic flows using Entropy Labels (EL). An ingress LSR cannot
insert ELs for packets going into a given tunnel unless an egress LSR
has indicated that it can process ELs for that tunnel. This draft
defines a mechanism to signal that capability using IS-IS. This
mechanism is useful when the label advertisement is also done via IS-
IS.
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors (1999)

Synthetic benzamide derivatives were investigated for their ability to inhibit histone deacetylase (HDA). In this study, one of the most active benzamide derivatives, MS-27-275, was examined with regard to its biological properties and antitumor efficacy. MS-27-275 inhibited partially purified human HDA and caused hyperacetylation of nuclear histones in various tumor cell lines. It behaved in a manner similar to other HDA inhibitors, such as sodium butyrate and trichostatin A; MS-27-275 induced p21(WAF1/CIP1) and gelsolin and changed the cell cycle distribution, decrease of S-phase cells, and increase of G1-phase cells. The in vitro sensitivity spectrum of MS-27-275 against various human tumor cell lines showed a pattern different than that of a commonly used antitumor agent, 5-fluorouracil, and, of interest, the accumulation of p21(WAF1/CIP1) tended to be faster and greater in the cell lines sensitive to MS-27-275. MS-27-275 administered orally strongly inhibited the growth in seven of eight tumor lines implanted into nude mice, although most of these did not respond to 5-fluorouracil. A structurally analogous compound to MS-27-275 without HDA-inhibiting activity showed neither the biological effects in cell culture nor the in vivo therapeutic efficacy. These results suggest that MS-27-275 acts as an antitumor agent through HDA inhibition and may provide a novel chemotherapeutic strategy for cancers insensitive to traditional antitumor agents.
Preparation of Organobentonites (2000)

In this paper,the gel test and thixotropy test have been done by myself-made organobentonites.The results show that myself-made organobentonites have attained country's standard.
Binding characteristics of dimeric IgG subclass complexes to human neutrophils. (1989)

Immune complexes were prepared by incubation of human IgG paraproteins with F(ab')2 fragments of the mAb K35 against the kappa-L chain of human IgG. The composition of these complexes was analyzed by centrifugation over sucrose gradients, by gel filtration, by RIA with either IgG Sepharose or K35 Sepharose and by double-labeling studies. The results indicated that the complexes consist of saturated tetramers composed of two IgG molecules cross-linked by two F(ab')2 fragments of the mAb. These complexes were used to study the binding of the different IgG subclasses to human neutrophils at 4 degrees C. Human neutrophils bound IgG3 complexes approximately three times faster than IgG1 complexes. Binding of IgG2 or IgG4 dimers to the neutrophils was undetectable. The same number of IgG1 complexes and IgG3 complexes bound to the neutrophils, but considerable inter-donor variation was found (mean number of Fc gamma R per neutrophil: 190,000, range 120,000 to 400,000). The Ka for the binding of IgG1 complexes to neutrophils (median 11 x 10(7) M-1) was lower than the Ka for the binding of IgG3 complexes (median 47 x 10(7) M-1). Competition studies between labeled IgG1 complexes or IgG3 complexes and unlabeled complexes showed that the Fc gamma R of human neutrophils do not display an IgG subclass specificity. Incubation of neutrophils with a mAb against the FcRIII completely blocked the binding of IgG1 complexes and IgG3 complexes. Incubation with a mAb against the FcRII reduced the affinity of the complexes for the neutrophils but had no effect on the maximum number of complexes bound. This indicates that one complex may bind simultaneously to one FcRIII and to one FcRII.
Laser diode area melting for high speed additive manufacturing of metallic components (2017)

Additive manufacturing processes have been developed to a stage where they can now be routinely used to manufacture net-shape high-value components. Selective Laser Melting (SLM) comprises of either a single or multiple deflected high energy fibre laser source(s) to raster scan, melt and fuse layers of metallic powdered feedstock. However this deflected laser raster scanning methodology is high cost, energy inefficient and encounters significant limitations on output productivity due to the rate of feedstock melting. This work details the development of a new additive manufacturing process known as Diode Area Melting (DAM). This process utilises customised architectural arrays of low power laser diode emitters for high speed parallel processing of metallic feedstock. Individually addressable diode emitters are used to selectively melt feedstock from a pre-laid powder bed. The laser diodes operate at shorter laser wavelengths (808 nm) than conventional SLM fibre lasers (1064 nm) theoretically enabling more efficient energy absorption for specific materials. The melting capabilities of the DAM process were tested for low melting point eutectic BiZn2.7 elemental powders and higher temperature pre-alloyed 17-4 stainless steel powder. The process was shown to be capable of fabricating controllable geometric features with evidence of complete melting and fusion between multiple powder layers.
Microbiota, Antibiotics, and Obesity (2014)

The causes of obesity, other than genes and environment, are poorly understood. A recent study showed that exposure of mice to antibiotics in early life induced lasting effects on body composition owing to alteration of the intestinal microbiota.
Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells (2004)

Spermatogonial stem cells (SSCs) self-renew and produce large numbers of committed progenitors that are destined to differentiate into spermatozoa throughout life. However, the growth factors essential for self-renewal of SSCs remain unclear. In this study, a serum-free culture system and a transplantation assay for SSCs were used to identify exogenous soluble factors that promote proliferation of SSCs. Mouse pup testis cells were enriched for SSCs by selection with an anti-Thy-1 antibody and cultured on STO (SIM mouse embryo-derived thioguanine and ouabain resistant) feeders in a serum-free defined medium. In the presence of glial cell line-derived neurotrophic factor (GDNF), SSCs from DBA/2J strain mice formed densely packed clumps of cells and continuously proliferated. However, other strains of mice required the addition of soluble GDNF-family receptor alpha-1 and basic fibroblast growth factor to support replication. The functional transplantation assay proved that the clump-forming cells are indeed SSCs. Thus, GDNF-induced cell signaling plays a central role in SSC self-renewal. The number of SSCs in culture doubled every 5.6 days, and the clump-forming cells strongly expressed Oct-4. Under these conditions, SSCs proliferated over 6 months, reconstituted long-term spermatogenesis after transplantation into recipient testes, and restored fertility to infertile recipients. The identification of exogenous factors that allow continuous proliferation of SSCs in vitro establishes the foundation to study the basic biology of SSCs and makes possible germ-line modification by sophisticated technologies. Moreover, the ability to recover, culture indefinitely, and transplant SSCs will make the germ-line of individual males available for periods extending beyond a normal lifetime.
EXTRACTING ATTRIBUTES AND THEIR VALUES FROM WEB PAGES (2003)

We propose a method for extracting attributes and their values from Web pages. Our method makes use of word distributions estimated from plain Web pages. The key idea is to estimate word distribution by consulting ontologies built from HTML tables. In a series of experiments, we show that estimated word distributions are useful for extracting attributes and their values in various kinds of HTML representations other than tables.
Factor XSanto Domingo. Evidence that the severe clinical phenotype arises from a mutation blocking secretion. (1991)

Factor X (FX) is a vitamin K-dependent plasma protein required for the intrinsic and extrinsic pathways of blood coagulation. FXSanto Domingo is a hereditary FX deficiency which is characterized clinically by a severe bleeding diathesis. The proposita has a FX activity of less than 1% and a FX antigen of less than 5%. We have determined the molecular basis of the defect in the FXSanto Domingo gene by amplification of all eight exons with polymerase chain reaction and subsequent sequence analysis. The patient is homozygous for a G----A transition in exon I at codon -20 (numbering the alanine at the NH2 terminus of the mature protein as +1), resulting in the substitution of arginine for glycine in the carboxy-terminal part of the signal peptide. This amino acid change occurs near the presumed cleavage site of the signal peptidase. We hypothesized that the mutation might prevent cleavage by the signal peptidase which in turn would impair proper secretion of the FX protein. To test this hypothesis, we compared the expression of wild type and mutant FX cDNA in a human kidney cell line. Wild type and mutant constructs in the expression vector pCMV4 were introduced into the human embryonic kidney cell line 293 by calcium phosphate transfection. FX antigen levels in the supernatant of the cells harboring the wild type construct were 2.4 micrograms/10(7) cells per 24 h, whereas antigen levels in media from cells containing the FXSanto Domingo construct were undetectable. No FX antigen was detected in the cell lysates of cells transfected with the mutant construct. To insure that the difference in protein levels was not due to a difference in steady state levels of mRNA, Northern analysis was performed on RNA from the cell lysates of both constructs. The results showed a transcript of the same size, present in roughly equal amounts, in both cases. Thus, the defect in the signal sequence of FXSanto Domingo exerts its effect posttranscriptionally. FXSanto Domingo is the first described example of a bleeding diathesis due to a mutation in the signal sequence.