gebhart/patrepeval huggingface dataset:
INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID (1969)

The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. Two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. In the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after the tumor was grown to moderate size caused a regression of the tumor. In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.
The Unwilling Hosts: State, Society and the Control of Guest Workers in South Korea (2002)

(2002). The Unwilling Hosts: State, Society and the Control of Guest Workers in South Korea. Asia Pacific Business Review: Vol. 8, No. 4, pp. 67-94.
[Mediastinal adenopathy and cancer of the prostate]. (1991)

The authors report a case of metastases from a carcinoma of prostate producing mediastinal adenopathy with compression. The clinical presentation was unusual as this is an unusual area for lymphadenopathy and an abnormal lymphatic pattern was invoked as a possible cause or that the lymphatic channels communicating with these nodes had an abnormal thoracic duct. The aetiological diagnosis was facilitated by the presence of a specific prostatic antigen on the lymph node biopsy which allowed one to use an effective androgen suppression therapy.
Development of new IgE specificities to hymenoptera allergens during venom-specific immunotherapy. (2005)

These results confirm that sIgE levels tend to reduce during SIT, and the bands identifying some allergens in the blot tend to decrease or disappear. Nonetheless venom SIT can be responsible for the induction of new sensitisations to other venom allergens, apparently without clinical relevance.
A method for specific amplification and PCR sequencing of individual members of multigene families: application to the study of steroid 21-hydroxylase deficiency. (1992)

Mutations at the human HLA-linked CYP21B locus are responsible for 21-hydroxylase deficiency, a recessively inherited disorder of steroidogenesis. The scope for PCR-based analysis of the CYP21B gene has been restricted by the very high sequence homology between CYP21B and a closely related pseudogene, CYP21A. Here we describe a novel PCR sequencing strategy that allows the independent amplification of the entire CYP21B coding sequence and the subsequent enzyme-mediated conversion of the PCR product to a single-stranded form for dideoxy sequencing. We have used this approach to characterize the 21-hydroxylase deficiency allele associated with HLA-B55, the most frequent HLA marker associated with a CYP21B point mutation in the British population, and also an HLA-B35 associated allele of Asian origin. Allele-specific oligonucleotide (ASO) hybridization analyses have confirmed the selective amplification of CYP21B genes and the identity of the pathological mutations. The method can be adapted to permit selective amplification and PCR sequencing of individual closely related members of other multigene families and small-copy-number repetitive DNA families.
Construction of A Multiple Myeloma Diagnostic Model by Magnetic Bead‐Based MALDI‐TOF Mass Spectrometry of Serum and Pattern Recognition Software (2009)

A diagnosis of multiple myeloma (MM) is difficult to make on the basis of any single laboratory test result. Accurate diagnosis of MM generally results from a number of costly and invasive laboratory tests and medical procedures. The aim of this work is to find a new, highly specific and sensitive method for MM diagnosis. Serum samples were tested in groups representing MM (n = 54) and non-MM (n = 108). These included a subgroup of 17 plasma cell dyscrasias, a subgroup of 17 reactive plasmacytosis, 5 B cell lymphomas, and 7 other tumors with osseus metastasis, as well as 62 healthy donors as controls. Bioinformatic calculations associated with MM were performed. The decision algorithm, with a panel of three biomarkers, correctly identified 24 of 24 (100%) MM samples and 46 of 49 (93.88%) non-MM samples in the training set. During the masked test for the discriminatory model, 26 of 30 MM patients (sensitivity, 86.67%) were precisely recognized, and all 34 normal donors were successfully classified; patients with reactive plasmacytosis were also correctly classified into the non-MM group, and 11 of the other patients were incorrectly classified as MM. The results suggested that proteomic fingerprint technology combining magnetic beads with MALDI-TOF-MS has the potential for identifying individuals with MM. The biomarker classification model was suitable for preliminary assessment of MM and could potentially serve as a useful tool for MM diagnosis and differentiation diagnosis.
Apple Polyphenols, Phloretin and Phloridzin: New Trapping Agents of Reactive Dicarbonyl Species (2008)

Reactive dicarbonyl species, such as methylglyoxal (MGO) and glyoxal (GO), have received extensive attention recently due to their high reactivity and ability to form advanced glycation end products (AGEs) with biological substances such as proteins, phospholipids, and DNA. In the present study, we found that both phloretin and its glucoside, phloridzin, the major bioactive apple polyphenols, could efficiently trap reactive MGO or GO to form mono- and di-MGO or GO adducts under physiological conditions (pH 7.4, 37 degrees C). More than 80% MGO was trapped within 10 min, and 68% GO was trapped within 24 h by phloretin. Phloridzin also had strong trapping efficiency by quenching more than 70% MGO and 60% GO within 24 h. The glucosylation of the hydroxyl group at position 2 could significantly slow down the trapping rate and the formation of MGO or GO adducts. The products formed from phloretin (or phloridzin) and MGO (or GO), combined at different ratios, were analyzed using LC/MS. We successfully purified the major mono-MGO adduct of phloridzin and found that it was a mixture of tautomers based on the one- and two-dimensional NMR spectra. Our LC/MS and NMR data showed that positions 3 and 5 of the phloretin or phloridzin A ring were the major active sites for trapping reactive dicarbonyl species. We also found that phloretin was more reactive than lysine and arginine in terms of trapping reactive dicarbonyl species, MGO or GO. Our results suggest that dietary flavonoids that have the same A ring structure as phloretin may have the potential to trap reactive dicarbonyl species and therefore inhibit the formation of AGEs.
Human endogenous retroviruses in health and disease: a symbiotic perspective (2004)

nature within the genome, HERVs have obvious potential for genetic disorders.
Thermodynamic analysis on energy densities of batteries (2011)

The average increase in the rate of the energy density of secondary batteries has been about 3% in the past 60 years. Obviously, a great breakthrough is needed in order to increase the energy density from the current 210 Wh kg−1 of Li-ion batteries to the ambitious target of 500–700 Wh kg−1 to satisfy application in electrical vehicles. A thermodynamic calculation on the theoretical energy densities of 1172 systems is performed and energy storage mechanisms are discussed, aiming to determine the theoretical and practical limits of storing chemical energy and to screen possible systems. Among all calculated systems, the Li/F2 battery processes the highest energy density and the Li/O2 battery ranks as the second highest, theoretically about ten times higher than current Li-ion batteries. In this paper, energy densities of Li-ion batteries and a comparison of Li, Na, Mg, Al, Zn-based batteries, Li-storage capacities of the electrode materials and conversion reactions for energy storage, in addition to resource and environmental concerns, are analyzed.
Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors (1995)

Many members of the cytokine receptor superfamily initiate intracellular signaling by activating members of the Jak family of tyrosine kinases. Activation of the same Jaks by multiple cytokines raises the question of how these cytokines activate distinct intracellular signaling pathways. Selection of particular substrates--the transcriptional activator Stat3 and protein tyrosine phosphatase PTP1D--that characterize responses to the ciliary neurotrophic factor-interleukin-6 cytokine family depended not on which Jak was activated, but was instead determined by specific tyrosine-based motifs in the receptor components--gp130 and LIFR--shared by these cytokines. Further, these tyrosine-based motifs were modular, because addition of a Stat3-specifying motif to another cytokine receptor, that for erythropoietin, caused it to activate Stat3 in a ligand-dependent fashion.
Fast and Effective Gold Leaching from a Desulfurized Gold Ore Using Acidic Sodium Chlorate Solution at Low Temperature (2013)

The effects of various leaching conditions for gold extraction from sulfur-containing gold ore using acidic sodium chlorate solution were investigated. The contents of gold and sulfur from the ore were 55.7 g/ton and 11.67 wt %, respectively. It was found that the presence of sulfur greatly inhibited gold extraction. The optimal desulfurization temperature, desulfurization time, leaching temperature, leaching time, adding rate of NaClO3, HCl concentration, weight ratio of NaCl to sample, agitation speed, and ratio of liquid lixiviant volume to solid sample weight were 650 °C, 2 h, 40 °C, 45 min, 0.25 mL/min, 3 M HCl, 0.2, 250 rpm, and 10, respectively. The gold extraction percentage and the weight loss percentage of the sample were 97% and 8.8%, respectively, under these optimal conditions. Gold leaching by this method was very fast and effective, and the temperature was low. These characteristics made it possible to apply this method in continuous operation mode in industry.
Separation of the Polyethylene Liner From Acetabular Cup Metal Backing (1992)

In three young patients with cementless Porous Coated Anatomic (PCA) total hip prostheses implanted two to four years previously, the polyethylene liner separated from metal backing. These cups were of the original PCA design, manufactured and packaged as single assembled components, rather than the more recent two-piece components packaged with interchangeable liners separate from the metal backing. Each case of separation was associated with the failure of the thin outer polyethylene rim and central polyethylene peg on the back of the liner that secures it to the metal backing. Cup liners should be securely attached to the metal backing. The possibility of polyethylene failure is considerable when cementless metal-backed acetabular cups are used in active young patients.
Bid-mediated Mitochondrial Pathway Is Critical to Ischemic Neuronal Apoptosis and Focal Cerebral Ischemia (2002)

We have investigated the role of the BH3-only pro-death Bcl-2 family protein, Bid, in ischemic neuronal death in a murine focal cerebral ischemia model. Wild-type and bid-deficient mice of inbred C57BL/6 background were subjected to 90-min ischemia induced by left middle cerebral artery occlusion followed by 72-h reperfusion. The volume of ischemic infarct was significantly smaller in the bid-deficient brains than in the wild-type brains, suggesting that Bid participated in the ischemic neuronal death. Indeed, following the ischemic treatment there was a significant reduction of apoptosis in the ischemic areas, particularly in the inner infarct border zone (the penumbra), of the bid-deficient brains. In addition, activation of Bid in the wild-type brains could be readily detected at approximately 3 h after ischemia, as evidenced by its proteolytic cleavage and translocation to the mitochondria as determined using Western blot analysis and immunofluorescence staining. Correspondingly, mitochondrial release of cytochrome c could be detected around the same time Bid was cleaved in the wild-type brains. However, no significant cytochrome c release was detected in the bid-deficient brains until 24 h later. This suggests that, although the mitochondrial apoptosis pathway might be activated by multiple mechanisms during focal cerebral ischemia, Bid is critical to its early activation. This notion was further supported by the finding that caspase-3 activation was severely impaired in the bid-deficient brains, whereas activation of caspase-8 was much less affected. Taken together, these data suggest that Bid is activated early in neuronal ischemia in a caspase-8-dependent fashion and that Bid is perhaps one of the earliest and most potent activators of the mitochondrial apoptosis pathway. Thus, the role of Bid in the induction of ischemic neuronal death may render this molecule an attractive target for future therapeutic intervention.
Complete genome sequence of a newly isolated lytic bacteriophage, EFAP-1 ofEnterococcus faecalis, and antibacterial activity of its endolysin EFAL-1 (2009)

Bacteriophage EFAP-1 and its lytic protein, EFAL-1, can be utilized as potent antimicrobial agents against Enterococcus spp. strains resistant to conventional antibiotics in hospital infections and also as environmental disinfectants to control disease-causing Enterococcus spp. in dairy farms.
Conformational analysis. XX. Stereochemistry of reaction of Grignard reagents with ortho esters. Synthesis of 1,3-dioxanes with axial substituents at C-2 (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational analysis. XX. Stereochemistry of reaction of Grignard reagents with ortho esters. Synthesis of 1,3-dioxanes with axial substituents at C-2Ernest L. Eliel and Franz W. NaderCite this: J. Am. Chem. Soc. 1970, 92, 3, 584–590Publication Date (Print):February 1, 1970Publication History Published online1 May 2002Published inissue 1 February 1970https://pubs.acs.org/doi/10.1021/ja00706a028https://doi.org/10.1021/ja00706a028research-articleACS PublicationsRequest reuse permissionsArticle Views444Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Giant spin hall effect (GSHE) logic design for low power application (2015)

Conventional CMOS transistors will reach its power wall, a huge leakage power consumption limits the performance growth when technology scales down, especially beyond 45nm technology nodes. Spin based devices are one of the alternative computing technologies that aims to replace the current MOS based circuits by taking the advantage of their attractive characteristics, including non-volatility, high integration density and small cell area. The development of technologies such as spin-transfer torque random access memory (STT-RAM) and spin torque majority gate logic has become a story of great success. However, most of these technologies faces problems like, small operation margin, poor fan-out ability, etc. As the latest spin technology, Giant Spin Hall Effect (GSHE) Magnetic Tunneling Junction (MTJ) demonstrates a much better operation speed, switching probability and resistance margin. By leveraging the benefit of greater power efficiency and area density, GSHE MTJ elements become a suitable candidate for spintronic logic gates. Compare with traditional MOS transistors based logic gates, GSHE MTJ based logic can operate as a non-volatile memory and requires a much smaller number of elements to perform same logical operations (i.e., 'AND', 'OR', 'NAND' or 'NOR' gate.). And compare with other spin based logics, GSHE MTJ based logic also provides an better performance, excellent CMOS process compatibility and great fan-out ability.
Humantenna (2012)

Computer vision and inertial measurement have made it possible for people to interact with computers using whole-body gestures. Although there has been rapid growth in the uses and applications of these systems, their ubiquity has been limited by the high cost of heavily instrumenting either the environment or the user. In this paper, we use the human body as an antenna for sensing whole-body gestures. Such an approach requires no instrumentation to the environment, and only minimal instrumentation to the user, and thus enables truly mobile applications. We show robust gesture recognition with an average accuracy of 93% across 12 whole-body gestures, and promising results for robust location classification within a building. In addition, we demonstrate a real-time interactive system which allows a user to interact with a computer using whole-body gestures
Optical nanolithography using a scanning near-field probe with an integrated light source (2008)

An ultracompact near-field optical probe is described that is based on a single, integrated assembly consisting of a gallium nitride (GaN) light-emitting diode (LED), a microlens, and a cantilever assembly containing a hollow pyramidal probe with a subwavelength aperture at its apex. The LED emits ultraviolet light and may be used as a light source for near-field photolithographic exposure. Using this simple device compatible with many commercial atomic force microscope systems, it is possible to form nanostructures in photoresist with a resolution of 35 nm, corresponding to λ/10.
P‐124: A 17.3‐inch WQHD Top‐Emission Foldable AMOLED Display with Outstanding Optical Performance and Visual Effects (2020)

A 17.3‐inch WQHD foldable AMOLED display with 10 bit depth was developed. Electrical regulation was carried out to realize high uniformity and contrast ratio. Nearly 100% Adobe and DCI‐P3 coverage revealed its outstanding color expression capacity. De‐mura and IR‐drop compensation IP were integrated to improve visual effects and user experience.
12. A Convolution Approach to N-Sided Patches and Vertex Blending (1994)

12.1. Introduction and Background Most commercial surface modelers used today employ four-sided patches joined together in what is topologically equivalent to a rectangular grid (e.g., Catia™, Geomod™, Euclid™, STRIM™, etc.). This is due primarily to the convenience of generalizing curve definitions by incorporating two orthogonal parameters into one surface. Coons' methods and the more specific tensor product approaches are examples [Far90]. However, objects that are not topologically a rectangular mesh create difficult problems for these methods (see Fig. 12.1). This creates the need for multisided or “N-sided” patches. A number of schemes for creating such patches have been developed and proposed. Objects of general topology require such patches. Initial attempts to solve the topology problem used four-sided Coons' patches degenerated to obtain three-sided patches [Fau78]. Special case three-and five-sided patches have been developed that use similar methods [Bar73], [Far86], [Cha84]. Another approach combined three-sided and four-sided patches into one more general patch [Jen87]. A popular technique joined four-sided patches at a common midpoint to form N-sided “macropatches” [Chi83], [Var87], [Hah89], [Sar87]. Recently, the definition of homogeneous, smooth N-sided patches has been developed [Var87], [Loo89], [Blo89].
Short synthesis of parabactin (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTShort synthesis of parabactinRaymond J. Bergeron and Steven J. KlineCite this: J. Am. Chem. Soc. 1982, 104, 16, 4489–4492Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/ja00380a032https://doi.org/10.1021/ja00380a032research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A uniform 290 nm periodic square structure on ZnO fabricated by two-beam femtosecond laser ablation (2007)

A uniform submicron periodic square structure was fabricated on the surface of ZnO by a technique of two linearly polarized femtosecond laser beams with orthogonal polarizations ablating material alternately. The formed two-dimensional ordering submicron structure consists of close-packed submicron squares with a spacial periodicity of 290 nm, which arises from the intercrossing of two orthogonal submicron ripple structures induced by the two beams respectively. The result demonstrates a noninterference effect of two-beam ablation based on the alternate technique, which should come from the polarization-dependent enhancement of the subwavelength ripple structure and the large interval of two alternate pulses. This two-beam alternate ablation technique is expected to open up prospects for the submicron fabrication of wide-bandgap materials.
Effect of culture temperature on fatty acid composition ofChlorella sorokiniana (1970)

Abstract Chlorella sorokiniana was grown for extraction of fatty acids at seven temperatures ranging from 14 C to 38 C. The predominant fatty acids in C. sorokiniana grown at 38 C were saturated (46% of total); at 22 C, triunsaturated (40% of total); and at 14 C diunsaturated (47% of total). Increasing temperature resulted in an increase in the degree of unsaturation from 14 C to 22 C, but further increases in temperature always resulted in a decrease in unsaturation. At any point in the temperature range used, an increased temperature always resulted in fatty acids with a lower average chain length. Total fatty acid production was greatest at the extremes of temperature and lowest at 26 C. The chain length and degree of saturation of fatty acids increased at temperatures lower than 22 C. Therefore, the fatty acids of C. sorokiniana do not have an increasingly lower melting point when the culture temperature is reduced at temperatures 22 C or below.