gebhart/patrepeval huggingface dataset:
Use of Puffers for Disruption of Sex Pheromone Communication of Codling Moths (Lepidoptera: Tortricidae) in Walnut Orchards (1996)

Journal Article Use of Puffers for Disruption of Sex Pheromone Communication of Codling Moths (Lepidoptera: Tortricidae) in Walnut Orchards Get access Harry H. Shorey, Harry H. Shorey 1 Department of Entomology, University of California, Riverside, CA 92521 1Affiliated with University of California, Kearney Agricultural Center, 9240 South Riverbend Avenue, Parlier, CA 92648. Search for other works by this author on: Oxford Academic PubMed Google Scholar Roland G. Gerber Roland G. Gerber 1 Department of Entomology, University of California, Riverside, CA 92521 1Affiliated with University of California, Kearney Agricultural Center, 9240 South Riverbend Avenue, Parlier, CA 92648. Search for other works by this author on: Oxford Academic PubMed Google Scholar Environmental Entomology, Volume 25, Issue 6, 1 December 1996, Pages 1398–1400, https://doi.org/10.1093/ee/25.6.1398 Published: 01 December 1996 Article history Received: 21 December 1995 Accepted: 14 August 1996 Published: 01 December 1996
Involuntary movement disorders associated with felbamate (1995)

Two children developed involuntary movements while taking felbamate as an adjunct to their antiepileptic regimen. One exhibited choreoathetosis and the other an acute dystonic reaction. In both children the symptoms resolved with no recurrence after felbamate discontinuance.
43.4: Low Power LC Display Using In‐Ga‐Zn‐Oxide TFTs Based on Variable Frame Frequency (2010)

Abstract By using an oxide semiconductor, we successfully prototyped a 3.4‐inch QHD LCD panel including data and scan drivers; their power consumption is reduced by variable frame frequency (from 1/60 fps to 120 fps) depending on images. Low frame frequency in displaying still images on a PC monitor can reduce eyestrain.
The kinetic mechanism of heme binding to human apohemoglobin. (1983)

The formation of hemoglobin from free CO-heme and apoprotein is, at minimum, a two-step process. The first reaction involves very rapid equilibration of the heme groups with hydrophobic regions of the globin molecule. The spectrum of the resultant heme-globin complex is analogous to that of CO-heme incorporated into phospholipid membranes. The Soret absorbance maximum of this species is at about 413 nm, which suggests strongly that the iron-histidine bond has not been formed. The equilibrium dissociation constant for the formation of the heme-globin complex is 6.2 +/- 2 microM at pH 7.2 and 10 degrees C. This constant increases with increasing pH, with the addition of inositol hexaphosphate, with modification of the protoporphyrin vinyl groups, and with increasing glycerol concentration. The second step in hemoglobin formation is unimolecular and appears to involve a large conformational transition which results in iron-histidine bond formation and the appearance of a native CO-hemoglobin spectrum. The rate of this process is 500 +/- 150 s-1 at pH 7.2 and 10 degrees C and is little affected by changes in pH, the addition of organic phosphates, or heme modification. Increasing the solvent viscosity to about 10 c.p. by the addition of 50% glycerol causes a 10-fold decrease in the rate of this conformational change. This suggests that large protein movements, presumably folding around the heme, are involved in the final stages of hemoglobin formation. Iron-histidine bond formation does not appear to be a rate-limiting step.
Evidence for High Frequency of Chromosomal Mosaicism in Spontaneous Abortions Revealed by Interphase FISH Analysis (2005)

Numerical chromosomal imbalances are a common feature of spontaneous abortions. However, the incidence of mosaic forms of chromosomal abnormalities has not been evaluated. We have applied interphase multicolor fluorescence in situ hybridization using original DNA probes for chromosomes 1, 9, 13, 14, 15, 16, 18, 21, 22, X, and Y to study chromosomal abnormalities in 148 specimens of spontaneous abortions. We have detected chromosomal abnormalities in 89/148 (60.1%) of specimens. Among them, aneuploidy was detected in 74 samples (83.1%). In the remaining samples, polyploidy was detected. The mosaic forms of chromosome abnormality, including autosomal and sex chromosomal aneuploidies and polyploidy (31 and 12 cases, respectively), were observed in 43/89 (48.3%) of specimens. The most frequent mosaic form of aneuploidy was related to chromosome X (19 cases). The frequency of mosaic forms of chromosomal abnormalities in samples with male chromosomal complement was 50% (16/32 chromosomally abnormal), and in samples with female chromosomal complement, it was 47.4% (27/57 chromosomally abnormal). The present study demonstrates that the postzygotic or mitotic errors leading to chromosomal mosaicism in spontaneous abortions are more frequent than previously suspected. Chromosomal mosaicism may contribute significantly to both pregnancy complications and spontaneous fetal loss.
MicroRNAs and haematology: small molecules, big function (2007)

MicroRNAs are a recently discovered class of small ( approximately 22nt) endogenously expressed translational-repressor RNAs that play key roles in many cellular pathways and whose aberrant expression appears to be a common feature of malignancy. MicroRNAs are expressed in specific haematological cell types and play important regulatory roles in early haematopoietic differentiation, erythropoiesis, granulocytosis, megakaryocytosis and lymphoid development. Additionally, there is an emerging body of research to suggest that microRNAs play an important role in the pathology of haematological malignancies. MicroRNAs have been found to act as both tumour suppressor molecules [e.g. MIRN15A (miR-15a), MIRN16-1 (miR-16-1)] in leukaemias and have oncogenic properties [e.g. MIRN155 (miR-155) and MIRN17-92 (miR-17-miR-92) cluster] in lymphomas. This review discusses the rapidly accumulating research that points to the major role microRNAs play in both haematopoiesis and haematological malignancy.
Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines (1997)

In the course of examining epitope-specific CTL responses to intramuscular plasmid DNA immunization with influenza nucleoprotein (NP)-expressing vectors, a nonimmunogenic mutant NP (NP(o)) was identified. The coding region of NP(o) differed from the wild-type A/PR/8/34 NP sequence (designated NP(v)) by three amino acid alterations in the carboxyl-terminal portion of the molecule remote from the H-2K(d) epitope (147-155) being monitored. Correction of these mutations restored the immunogenicity of the native sequence, indicating that sequence alterations remote from the CTL epitope in question can profoundly influence its immunogenicity. In an effort to identify general, nonstructural means of enhancing the CTL response to weak plasmid DNA immunogens, vectors were constructed expressing NP(o) in tandem with the costimulatory molecules B7-1 or B7-2. Co-linear expression of NP(o) with B7-2, but not B7-1, significantly increased the NP epitope-specific CTL response. In addition, coinjection of these NP(o) plasmids with granulocyte-macrophage CSF- and/or IL-12-expressing vectors also restored near native NP-specific CTL responses. Thus, the coexpression of certain costimulatory molecules and/or cytokines, in concert with a non-self gene delivered as an intramuscular plasmid DNA immunogen, can significantly enhance Ag-specific CTL responses.
Spatially resolved spectral interferometry for determination of subsurface structure (1999)

We describe an instrument capable of obtaining two-dimensional images of subsurface structure in real time with no moving parts. The technique is based on spectral interferometry and uses an imaging spectrograph to obtain spatially resolved spectra. A test sample consisting of microscope coverslips and a Ronchi grating was measured, illustrating the system's depth resolution of 38 mum and transverse resolution of at least 12.7 mum . The technique is readily adaptable to endoscopic delivery as well as three-dimensional real-time image acquisition.
Priming of immune responses to hepatitis B surface antigen in young mice immunized in the presence of maternally derived antibodies (2001)

Early vaccination is necessary to protect infants from various infectious diseases. However, this is often unsuccessful largely due to the immaturity of the neonatal immune system. Furthermore, maternally derived antibodies can interfere with active immunization. We have previously shown in young mice that immune responses against several different antigens can be improved by the addition of oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG ODN). In this study we have evaluated immunization of newborn (1-7-day-old) BALB/c mice against hepatitis B surface antigen (HBsAg), with alum and/or CpG ODN, in the presence of high levels of maternal antibody against HBsAg (anti-HBs). Seroconversion rates and anti-HBs titers were compared to those induced by a HBsAg-expressing plasmid, since other studies had suggested DNA vaccines to be superior to protein vaccines in young mice with maternal antibody. HBsAg/alum/CpG ODN was superior to DNA vaccine in inducing HBsAg-specific CTL responses in young mice in the presence of maternally transferred anti-HBs antibodies. However, B cell responses to both HBsAg/alum/CpG ODN and DNA vaccines remained weak in the presence of maternally transferred anti-HBs antibodies.
Rate process model for arterial tissue thermal damage: Implications on vessel photocoagulation (1994)

A numerical model for thermal damage to human arterial tissue is presented, based on protein denaturation kinetics. The model involves determination of coefficients of rate processes A & delta E, which are tissue type-dependent (arterial tissue in this study), and definition of threshold damage. A feedback-controlled constant surface temperature device was used to induce 80 coagulative lesions of arterial human tissue ranging in temperature from 66 degrees C to 76 degrees C and in duration from 15 to 1,500 seconds. The measured coefficients were determined to be A = 5.6 x 10(63) s-1 and delta E = 430 KJ mole-1. These numerical values closely approximate the coefficients of the rate process for denaturation of collagen molecules. These and other histological observations strongly suggest collagen to be the primary coagulating component of arterial tissue at the onset of thermal coagulative damage. The ability of this model to predict onset of tissue coagulation during laser coagulation was studied using 10 postmortem human arterial samples exposed to argon laser irradiation.
Evaluation of Radiolabeled (Hetero)Aromatic Analogues of N-(2-diethylaminoethyl)-4-iodobenzamide for Imaging and Targeted Radionuclide Therapy of Melanoma (2008)

Targeted radionuclide therapy using radioiodinated compounds with a specific affinity for melanoma tissue is a promising treatment for disseminated melanoma, but the candidate with the ideal kinetic profile remains to be discovered. Targeted radionuclide therapy concentrates the effects on tumor cells, thereby increasing the efficacy and decreasing the morbidity of radiotherapy. In this context, analogues of N-(2-diethylaminoethyl)-4-iodobenzamide (BZA) are of interest. Various (hetero)aromatic analogues 5 of BZA were synthesized and radioiodinated with (125)I, and their biodistribution in melanoma-bearing mice was studied after i.v. administration. Most [ (125)I] 5-labeled compounds appeared to bind specifically and with moderate-to-high affinity to melanoma tumor. Two compounds, 5h and 5k, stood out with high specific and long-lasting uptake in the tumor, with a 7- and 16-fold higher value than BZA at 72 h, respectively, and kinetic profiles that makes them promising agents for internal targeted radionuclide therapy of melanoma.
Structural analysis of unstable intermediate and stable forms of recombinant fowlpox virus (1991)

The stability and structure of the products of recombination in a fowlpox virus (FPV) system using the thymidine kinase (TK) gene as the insertion site were examined. A 4.6 kb chimeric DNA fragment from the pUV1 expression vector, containing the bacterial lacZ gene and the vaccinia virus P7.5 promoter, was ligated into the XbaI site of the FPV TK gene. The resulting vector, pFTKlacZb, was transfected into chicken embryo fibroblast cultures infected with FPV at an m.o.i. of 0.1. Recombinants were screened for the expression of beta-galactosidase. Five recombinants were isolated and plaque-purified to 80 to 90% for expression of beta-glucosidase. Serial cell culture passage of the recombinants led to the gradual reappearance of the non-recombinant parental phenotype. Southern hybridization analysis of EcoRI fragments from all five recombinants indicated that a single cross-over homologous recombination had occurred between either the 5' or the 3' end fragments of the TK gene, generating unstable intermediate recombinants incorporating the entire pFTKlacZb vector. Secondary intermolecular or intramolecular recombination of intergenic repetitive sequences within the intermediate recombinants appears to have resulted in frequent regeneration of the parental genotype and an infrequent generation of more stable recombinants. A method was developed to select stable recombinants by passage of the intermediate recombinants in chicken embryo fibroblast cultures treated with 5-bromo-2'-deoxyuridine.
Spin-transfer excitations of permalloy nanopillars for large applied currents (2005)

Using measurements of the spectra of microwave-frequency resistance oscillations, we determine the room-temperature phase diagram of magnetic excitations caused by torques from dc spin-polarized currents in (thin permalloy)/copper/(thick permalloy) multilayer samples. We extend the measurements to larger values of current than have been reported previously. We find several additional modes that we are able to identify with motion of the thick magnetic layer as well as the thin one. Peaks in the microwave spectra at multiple frequencies suggest that spatially nonuniform dynamical states can be important in some circumstances. We compare the experimental phase diagram with simple theoretical models and achieve a good qualitative agreement.
Distinct Specificities of Inwardly Rectifying K+Channels for Phosphoinositides (1999)

Activation of several inwardly rectifying K(+) channels (Kir) requires the presence of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)). The constitutively active Kir2.1 (IRK1) channels interact with PtdIns(4,5)P(2) strongly, whereas the G-protein activated Kir3.1/3.4 channels (GIRK1/GIRK4), show only weak interactions with PtdIns(4,5)P(2). We investigated whether these inwardly rectifying K(+) channels displayed distinct specificities for different phosphoinositides. IRK1, but not GIRK1/GIRK4 channels, showed a marked specificity toward phosphates in the 4,5 head group positions. GIRK1/GIRK4 channels were activated with a similar efficacy by PtdIns(3,4)P(2), PtdIns(3,5)P(2), PtdIns(4,5)P(2), and PtdIns(3,4,5)P(3). In contrast, IRK1 channels were not activated by PtdIns(3,4)P(2) and only marginally by high concentrations of PtdIns(3,5)P(2). Similarly, high concentrations of PtdIns(3,4,5)P(3) were required to activate IRK1 channels. For either channel, PtdIns(4)P was much less effective than PtdIns(4,5)P(2), whereas PtdIns was inactive. In contrast to the dependence on the position of phosphates of the phospholipid head group, GIRK1/GIRK4, but not IRK1 channel activation, showed a remarkable dependence on the phospholipid acyl chains. GIRK1/GIRK4 channels were activated most effectively by the natural arachidonyl stearyl PtdIns(4,5)P(2) and much less by the synthetic dipalmitoyl analog, whereas IRK1 channels were activated equally by dipalmitoyl and arachidonyl stearyl PtdIns(4,5)P(2). Incorporation of PtdInsP(2) into the membrane is necessary for activation, as the short chain water soluble diC(4) PtdIns(4,5)P(2) did not activate either channel, whereas activation by diC(8) PtdIns(4, 5)P(2) required high concentrations.
Robust estimation of resource consumption for SQL queries using statistical techniques (2012)

The ability to estimate resource consumption of SQL queries is crucial for a number of tasks in a database system such as admission control, query scheduling and costing during query optimization. Recent work has explored the use of statistical techniques for resource estimation in place of the manually constructed cost models used in query optimization. Such techniques, which require as training data examples of resource usage in queries, offer the promise of superior estimation accuracy since they can account for factors such as hardware characteristics of the system or bias in cardinality estimates. However, the proposed approaches lack robustness in that they do not generalize well to queries that are different from the training examples, resulting in significant estimation errors. Our approach aims to address this problem by combining knowledge of database query processing with statistical models. We model resource-usage at the level of individual operators, with different models and features for each operator type, and explicitly model the asymptotic behavior of each operator. This results in significantly better estimation accuracy and the ability to estimate resource usage of arbitrary plans, even when they are very different from the training instances. We validate our approach using various large scale real-life and benchmark workloads on Microsoft SQL Server.
Spray-dried enteric solid dispersion as a novel oral delivery system for a pentapeptide analog of thymopentin (1992)

IRI-426 (Ac-Arg-Pro-Asp-Val-Phe-NH2) is a biologically active and enzyme-resistant analog of thymopentin (Arg-Lys-Asp-Val-Tyr), a pentapeptide corresponding to an active site of the thymic hormone thymopoietin. Enteric formulation of this enzyme resistant pentapeptide could be valuable for oral administration by providing protection from acid proteolysis in the gastric juice and release and absorption in the duodenum. Using a drug-to-polymer ratio of 1 to 10, an enteric solid dispersion of IRI-426 was prepared with an acid-insoluble, pH-sensitive polymer Eudragit S-100, by the spray-drying technique. The USP rotating paddle method and 190 proof ethyl alcohol, USP were used as received. All solvents used in the analytical procedure were of HPLC grade.
Making feasible walking motion of humanoid robots from human motion capture data (2003)

This work presents a study of the human/humanoid locomotion system and a method for adaptation of the human motion capture data (HMCD) for driving a humanoid robot. The analysis uses the previously defined concept of the zero moment point (ZMP) which provides a basis for the adaptation of the HMCD. An appropriate model of the robot foot, in agreement with the HMCD, is proposed. This model is used to plan a desired ZMP trajectory. A scheme for approximately matching the actual ZMP trajectory to the desired ZMP trajectory, through periodic joint motion correction at selected joints, is discussed. A method for resolving the ground reaction forces at the foot is also proposed.
Effect of Increased Temperature in Apical Regions of Maize Ears on Starch-Synthesis Enzymes and Accumulation of Sugars and Starch (1985)

Apical florets of maize (Zea mays L.) ears differentiate later than basal florets and form kernels which have lower dry matter accumulation rates. The purpose of this study was to determine whether increasing the temperature of apical kernels during the dry matter accumulation period would alter the difference in growth rate between apical and basal kernels. Apical regions of field-grown maize (cultivar Cornell 175) ears were heated to 25 3C from 7 days after pollination to maturity (tip-heated ears) and compared with unheated ears (control). In controls, apicalkernel endosperm had 24% smaller dry weight at maturity, lower concentration of sucrose, and lower activity of ADP-Glc starch synthase than basal-kernel endosperm, whereas ADP-Glc-pyrophosphorylase (ADPG-PPase) activities were similar. In tip-heated ears apical-kernel endosperm had the same growth rate and final weight as basal-kernel endosperm and apical kernels had higher sucrose concentrations, higher ADP-Glc starch synthase activity, and similar ADPG-PPase activity. Total grain weight per ear was not increased by tip-heating because the increase in size of apical kernels was partially offset by a slight decrease in size of the basal-and middle-position kernels. Tip-heating hastened some of the developmental events in apical kernels. ADPG-PPase and ADP-Glc starch synthase activities reached peak levels and starch con- centration began rising earlier in apical kernels. However, tip-heating did not shorten the period of starch accumulation in apical kernels. The results indicate that the lower growth rate and smaller size of apical kernels are not solely determined by differences in prepollination floret development.
Optical Properties and Sugar Content Determination of Commercial Carbonated Drinks using Surface Plasmon Resonance (2007)

In this study, an optical sensor based on Kretschmann SPR technique was used to detect the sugar content in commercial carbonated drinks. Three samples of carbonated drinks labeled as "Coke", "100 Plus" and "F&amp;N Orange" have been chosen for angle scan SPR measurements. All the measurements were carried out at room temperature using He-Ne laser beam (632.8nm, 5mW) as a light source. The commercially available carbonated samples were diluted by adding distilled water to produce solutions with different sugar content. The results show that the shift of resonance angle (&amp;Delta;&amp;theta;&lt;sub&gt;SPP&lt;/sub&gt;) increases linearly with the sugar content in which the detection limit and sensor sensitivity could be quantified. Therefore, this technique could be used as optical sensor for detecting sugar content in carbonated soft drinks.
Data distribution satellite system architecture concept (1990)

This paper describes a future communications satellite system architecture concept called the Data Distribution Satellite (DDS). The DDS is envisioned as a new system to be used as an adjunct to TDRS/TDAS for distributing new NASA science data throughout the U.S. as well as internationally. The DDS would also provide networking capability for interchange of science database files among science users and NASA archive depositories. Experimenters would be able to access and control their experimental packages remotely, relieving astronaut workload. This paper gives a conceptual system design based on year 1995 technology. Features of the design include use of Ku and Ka-bands, use of fixed spot beams, 2 Gb/s throughput, and on-board demodulation and switching. The satellite dry mass is 1,300 kg and end-of-life power is 4 kW.
Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain (2016)

It has been reported that oscillatory gamma activity participates in brief acute pain and tonic ongoing pain. It is of great interest to determine whether the gamma activity is involved in chronic pain since chronic pain is a more severe pathological condition characterized by pain persistency. To investigate the oscillatory gamma activity in chronic pain, in the present study, we recorded spontaneous electrocorticogram (ECoG) signals during chronic pain development in rats with chronic inflammatory pain induced by monoarthritis. Power spectrum analysis of ECoG data showed that gamma power increased significantly at the late stage of chronic inflammatory pain. The increased gamma activity occurred mainly at electrodes over primary somatosensory cortices. In rats with chronic pain, the gamma power was positively correlated with the hyperalgesia measured by laser energy that elicited hindpaw withdrawal response. Furthermore, an increased coupling between the amplitude of gamma power and the phase of theta oscillations was observed in chronic inflammatory pain condition. These results indicate an enhanced spontaneous gamma activity in chronic pain and suggest a potential biomarker for the severity of chronic pain.