gebhart/patrepeval huggingface dataset:
Fast SAGD and Geomechanical Mechanisms (2002)

Abstract This paper outlines a new variation of the SAGD process, called Fast SAGD. Numerical simulation of the Fast SAGD process using a thermal reservoir simulation software package is performed in order to investigate the operating strategy. A geomechanical model is used to analyze the impact of geomechanics on the recovery process. It is concluded from this study that, besides gravity, steam drive, shear failure, and pore volume deformation are the additional mechanisms in this recovery process. Clearly, Fast SAGD is a process with high productivity and low cumulative steam-oil ratio. Introduction Cyclic steam stimulation (CSS) was first discovered in Western Venezuela in 1959 and developed in the field. In Alberta, injection of any fluid into the oil sands is problematic because of the very low mobility of the in situ bitumen. As a result, the injection pressure is increased to a level to part the formation. In Cold Lake1, an injection pressure of 12 MPa is reached and steam is introduced into the formation at high rates of about 200 m3/day. However, the major problem with CSS as it is practiced in Alberta is that typically 15 to 20% of the bitumen is recovered from the resource, even in a pattern comprised of closely spaced vertical wells. For a reservoir with gas cap or bottom water, the parting pressure would probably leak more heat into the over/under burden by heat convection and decrease heat efficiency. The Steam-Assisted Gravity Drainage (SAGD) process was developed in the 1980s, and currently several pilot projects are operated in Alberta. In this process, steam is injected continuously into a horizontal well, located parallel to, and closely above, a horizontal production well at the base of the reservoir. Heated oil drains by gravity and steam fills the vacated pore volume. It has been reported that SAGD is an attractive recovery process, which results in low steam-oil ratios (SOR). However, a challenge for the SAGD is to try to promote the lateral and downward expansion of the steam chamber2. A new process, called Fast SAGD, which combines SAGD and CSS, was recently3,4 proposed. Reservoir simulation of the process has shown that Fast SAGD is a process with relatively high productivity and low operating pressure. FAST SAGD PROCESS Fast SAGD is a combination of both SAGD and CSS, as can be seen in Figure 1. After the SAGD steam chamber is developed, steam is injected into a single horizontal well, called offset well, 50 m away from the SAGD well pair, in a cyclic mode in order to help propagate the steam chamber expansion down the reservoir. The first cycle lasts one year, nine months of steam injection followed by three months of production. In the second cycle, after six months of steam injection, the offset well is converted to a production well for the remainder of time. Meanwhile, extra steam is injected into the SAGD injector to maintain and expand the combined steam chamber that is generated by the offset well. Two-week soak is considered in the cyclic steaming of the offset well.
Response Characterization of an Inexpensive Aerosol Sensor (2017)

Inexpensive aerosol sensors have been considered as a complementary option to address the issue of expensive but low spatial coverage air quality monitoring networks. However, the accuracy and response characteristics of these sensors is poorly documented. In this study, inexpensive Shinyei PPD42NS and PPD60PV sensors were evaluated using a novel laboratory evaluation method. A continuously changing monodisperse size distribution of particles was generated using a Vibrating Orifice Aerosol Generator. Furthermore, the laboratory results were validated in a field experiment. The laboratory tests showed that both of the sensors responded to particulate mass (PM) concentration stimulus, rather than number concentration. The highest detection efficiency for the PPD42NS was within particle size range of 2.5-4 µm, and the respective optimal size range for the PPD60PV was 0.7-1 µm. The field test yielded high PM correlations (R² = 0.962 and R² = 0.986) for viable detection ranges of 1.6-5 and 0.3-1.6 µm, when compared to a medium cost optical dust monitor. As the size distribution of atmospheric particles tends to be bimodal, it is likely that indicatively valid results could be obtained for the PM<sub>10-2.5</sub> size fraction (particulate mass in size range 2.5-10 µm) with the PPD42NS sensor. Respectively, the PPD60PV could possibly be used to measure the PM<sub>2.5</sub> size fraction (particulate mass in size below 2.5 µm).
Serial Processing in the Human Somatosensory System (2004)

Although numerous anatomical and electrophysiological findings in animal studies have supported a hierarchical scheme of somatosensory processing, precise activation timings of each cortical area are not known. Therefore we examined the temporal relationship of activities among multiple cortical areas using magnetoencephalography in humans. We found activations in Brodmann's areas 3b, 4, 1, 5 and the secondary somatosensory cortex region in the right hemisphere following transcutaneous electrical stimulation of the dorsum of the left hand. The mean onset latencies of each cortical activity were 14.4, 14.5, 18.0, 22.4 and 21.7 ms, respectively. The differences of onset latencies among these activations indicated the serial mode of processing both through the postcentral gyrus and through the primary and secondary somatosensory cortices.
Lipid Peroxidation and Antioxidant Status in Head and Neck Squamous Cell Carcinoma Patients (2009)

Oxidative stress, a consequence of an imbalance between the formation and inactivation of reactive oxygen species, may be involved in the pathogenesis of many diseases including cancer. To evaluate the magnitude of oxidative stress, a study on the plasma levels of superoxide dismutase, total thiols, ascorbic acid and malondialdehyde (MDA) has been done in head and neck squamous cell carcinoma patients before the start of any oncological treatment and compared with healthy controls. The specific activity of superoxide dismutase in cancer patients is decreased significantly when compared to the control (p < 0.05). The total thiol and ascorbic acid levels are significantly reduced (p < 0.005) whereas MDA levels are significantly increased in the patients (p < 0.00005). Our findings show that the oxidative stress is elevated in cancer patients as evidenced by elevated levels of lipid peroxidation products and depletion of enzymatic and non-enzymatic antioxidants.
Bisphosphonates (2007)

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. There is considerable new knowledge about how BPs work. Their classical pharmacological effects appear to result from two key properties: their affinity for bone mineral and their inhibitory effects on osteoclasts. Mineral binding affinities differ among the clinically used BPs and may influence their differential distribution within bone, their biological potency, and their duration of action. The inhibitory effects of the nitrogen-containing BPs (including alendronate, risedronate, ibandronate, and zoledronate) on osteoclasts appear to result from their inhibition of farnesyl pyrophosphate synthase (FPPS), a key branch-point enzyme in the mevalonate pathway. FPPS generates isoprenoid lipids used for the posttranslational modification of small GTP-binding proteins essential for osteoclast function. Effects on other cellular pathways, such as preventing apoptosis in osteocytes, are emerging as other potentially important mechanisms of action. As a class, BPs share several common properties. However, as with other classes of drugs, there are obvious chemical, biochemical, and pharmacological differences among the various individual BPs. Each BP has a unique profile that may help to explain potential important clinical differences among the BPs, in terms of speed of onset of fracture reduction, antifracture efficacy at different skeletal sites, and the degree and duration of suppression of bone turnover. As we approach the 40th anniversary of the discovery of their biological effects, there remain further opportunities for using their properties for medical purposes.
Genomlc analysis II: isolation of high molecular weight heteroduplex DNA following differential methylase protection and Formamide-PERT hybridization (1986)

Understanding the nature of DNA sequence differences among individuals is important to the understanding of fundamental questions in biology. To analyze such differences in complex genomes new approaches must be developed. We report two new techniques which aid in this effort. First, we have developed a modification of the Phenol Emulsion Reassociation Technique (PERT) that allows hybridization of long (20 kb and longer) single copy heteroduplex DNA fragments from human genomic DNAs. Secondly, by using a differential methylase protection technique we have shown that double methylase resistant heteroduplex DNA molecules can be size fractionated away from reannealed single methylase resistant homoduplex DNA molecules. These methods will be useful in obtaining DNA from chromosomal subregions linked to the inheritance of a specific trait or condition as described in the preceding paper and could also be used to create a map of the chromosomal subregion which includes the gene for the trait.
Quasi-ZVS active auxiliary commutation circuit for two switches forward converter (2002)

This paper presents a family of single-ended power converters that, adequately designed and commanded, can perform ZVS turn-off and turn-on with a value near to zero namely quasi-ZVS (QZVS) at main switches. The auxiliary circuit presents low reactive energy and is composed of one inductor, one diode and one switch, which operate with ZCS. To demonstrate the feasibility of the proposed technique, it is applied to a two switch forward converter. It is not necessary the use of a third winding in the transformer nor auxiliary voltage sources to achieve soft switching. The implementation is possible due to the use of an appropriate command, different than is used conventionally in two switch forward converters. Complete analysis of the operation stages, as well as the design procedures for the correct operation of the converter are presented. Experimental results obtained from a prototype of 250W/48V@100kHz demonstrate the feasibility of this active auxiliary commutation circuit (AACC) applied to two switch forward converters. Furthermore, a new concept of switching is introduced, where the main switches commutate with QZVS.
Peptides Derived from BH3 Domains of Bcl-2 Family Members:  A Comparative Analysis of Inhibition of Bcl-2, Bcl-xL and Bax Oligomerization, Induction of Cytochrome c Release, and Activation of Cell Death (2002)

Overexpression of Bcl-2, an anti-apoptotic oncoprotein, is commonly observed in a variety of human malignancies and is associated with resistance to chemotherapy and radiotherapy. Although the precise mechanism of Bcl-2 action remains elusive, current evidence indicates that Bcl-2 inhibits apoptosis by binding and inhibiting pro-apoptotic molecules such as Bax. Therefore, agents that disrupt the ability of Bcl-2, or other anti-apoptotic molecules, to bind to pro-apoptotic molecules may have therapeutic value. Several studies have shown that the BH3 domains of Bcl-2 and Bax are critically important for Bax/Bcl-2 heterodimerization. In this report, we designed and synthesized peptides based on the BH3 domains of three distinct Bcl-2 family members, Bcl-2, Bax and Bad. In vitro interaction assays were used to compare the abilities of the different peptides to inhibit Bax/Bcl-2 and Bax/Bcl-x(L) heterodimerization, as well as Bcl-2 and Bax homodimerization. Bax BH3 peptide (20-amino acids) potently inhibited both Bax/Bcl-2 and Bax/Bcl-x(L) interactions, exhibiting IC(50) values of 15 and 9.5 microM, respectively. The Bad BH3 peptide (21 amino acids) was slightly more potent than Bax BH3 at inhibiting Bax/Bcl-x(L) but failed to disrupt Bax/Bcl-2. Bcl-2 BH3 peptide (20-amino acids) was inactive toward Bax/Bcl-2 and had only a weak inhibitory effect on Bax/Bcl-x(L) heterodimerization. All three BH3 peptides failed to significantly inhibit homodimerization of Bcl-2 or Bax. Consistent with its ability to disrupt Bax/Bcl-2 heterodimerization, Bax BH3 peptide was able to overcome Bcl-2 overexpression and induce cytochrome c release from mitochondria of Bcl-2-overexpressing Jurkat T leukemic cells. Bad BH3 peptide, while potently inducing cytochrome c release in wild-type Jurkat cells, only partially overcame the effects of Bcl-2 overexpression. Bcl-2 BH3 failed to induce cytochrome c release, even in wild-type cells. Delivery of the Bax BH3 and Bad BH3 peptides into wild-type Jurkat cells induced comparable levels of cell death. In cells overexpressing Bcl-2, the potency of Bax BH3 peptide was similar to that seen in wild-type cells, while the efficacy of Bad BH3 peptide was reduced. By contrast, in Bcl-x(L)-overexpressing cells, Bad BH3 exhibited greater cell-killing activity than Bax BH3. The Bcl-2 BH3 peptide and a mutant Bax BH3 peptide had no appreciable effect on Jurkat cells. Together, our data suggest that agents based on the Bax BH3 domain may have therapeutic value in cancers overexpressing Bcl-2, while agents based on the BH3 domain of Bad may be more useful for tumors overexpressing Bcl-x(L).
Longitudinal examination of health outcomes associated with botulinum toxin use in children with cerebral palsy. (2004)

A prospective cohort study with annual follow-up was conducted on 172 children with spastic type cerebral palsy receiving botulinum toxin type A (BTX) injections for spasticity management. A mixed modeling procedure was used to identify changes in both physical functioning outcomes for the child (using the WeeFIM measure) as well as quality of life of the parent caregiver (using the Stein and Reissman Impact on the Family Scale) with increasing utilization of BTX injections. The study found that each additional BTX injection administration was associated with a 2.3% improvement in the WeeFIM compared to the average baseline score (p < .01). Similarly, the study found an improvement of 2.5% compared to baseline in the parent's overall perception of the severity of the child's condition with each additional BTX injection administration (p < .001). These findings suggest that BTX injections may be associated with beneficial outcomes in childhood spasticity.
Microfluidics Digital PCR Reveals a Higher than Expected Fraction of Fetal DNA in Maternal Plasma (2008)

Microfluidics digital PCR represents an improvement over previous methods for quantifying fetal DNA in maternal plasma, enabling diagnostic and research applications requiring precise quantification. This approach may also impact other diagnostic applications of plasma nucleic acids, e.g., in oncology and transplantation.
Analysis of the Antiviral Activities of Natural IFN- α Preparations and Their Subtype Compositions (2001)

Here we report on the antiviral effects of two commercially available natural interferon-alpha (IFN-alpha) preparations, their subtype compositions, and the effects of combinations of pairs of the subtypes on virally infected cells. Our results show that the antiviral effects of these preparations depend on the target cell and on the infecting virus. The component subtypes vary with the preparations, and combinations of pairs of IFN-alpha subtypes may have synergistic or competitive effects. Our results suggest that optimal preparations of synergistically acting subtypes may provide more therapeutic benefit to patients.
Comprehensive Survey on Distance/Similarity Measures between Probability Density Functions (2007)

Distance or similarity measures are essential to solve many pattern recognition problems such as classification, clustering, and retrieval problems. Various distance/similarity measures that are applicable to compare two probability density functions, pdf in short, are reviewed and categorized in both syntactic and semantic relationships. A correlation coefficient and a hierarchical clustering technique are adopted to reveal similarities among numerous distance/similarity measures.
Clinical results of radionuclide therapy of neuroendocrine tumours with 90Y-DOTATATE and tandem 90Y/177Lu-DOTATATE: which is a better therapy option? (2011)

The results indicate that therapy with tandem radioisotopes (90Y/177Lu-DOTATATE) provides longer overall survival than with a single radioisotope (90Y-DOTATATE) and the safety of both methods is comparable.
Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene (1992)

TS/A is a spontaneous adenocarcinoma, apparently not immunogenic in BALB/cnAnCr mice. TS/A cells are unable to stimulate a syngeneic antitumor response either in vitro or in vivo. To evaluate the immunogenic potential of IL-2-releasing neoplastic cells, we used an expression vector to introduce the cDNA coding for murine IL-2 into TS/A cells. Six clones releasing between 30 and 6800 U of IL-2/10(5) cells/ml/48 h have been isolated. Both low (30 U, B1.30) and high (6000 U, B4.6000) IL-2-releasing clone are capable of stimulating a proliferative and cytotoxic response in syngeneic cultures. While the B1.30 clone grows in 60% of syngeneic mice with a delayed pattern, the five clones that release higher levels of IL-2 are promptly rejected. Rejection is associated with neutrophil infiltration, the intensity of which is directly proportional to the amount of IL-2 released. NK cells and CD4+ lymphocytes are uninfluential, whereas CD8+ lymphocytes play only a minor role. This neutrophil-dominated rejection leaves a long-lasting, tumor-specific, T lymphocyte-mediated immune memory. For its induction, CD4+ lymphocytes are required. Their specific activation appears to depend on both the amount of IL-2 released and the granulocyte-mediated reaction that may lead to a more efficient presentation of tumor-associated Ag. These data support the notion that, after transduction of IL-2 gene, cancer cells may elicit an immune antitumor response, and stress the potential use of IL-2 as a component of new tumor vaccines.
Inhibition of internalization of glucose transporters and IGF-II receptors. Mechanism of action of MHC class I-derived peptides which augment the insulin response in rat adipose cells. (1993)

Peptides from the alpha 1 domain of the major histocompatibility complex class I antigen (MHC class I), e.g. Dk-(61-85) and Dk-(62-85), have been shown previously to augment glucose uptake in insulin-stimulated cells and to inhibit insulin receptor internalization (Stagsted, J., Reaven, G. M., Hansen, T., Goldstein, A., and Olsson, L. (1990) Cell 62, 297-307). We now report that these peptides inhibit by 80-100% the internalization of glucose transporters (GLUT4) and insulin-like growth factor II (IGF-II) receptors in insulin-stimulated cells and correspondingly double insulin-stimulated glucose transport activity and the number of GLUT4 and IGF-II receptors on the cell surface. In addition, the peptides enhance the apparent affinity about 3-fold of IGF-II binding to its receptor. It is concluded that the effects of the peptides on glucose transport and IGF-II binding are a consequence of the peptide-mediated inhibition of internalization of GLUT4 and IGF-II receptor. The active peptides are derived from the alpha 1 domain of a MHC class I molecule, suggesting that the latter is involved in regulation of internalization of cell surface integral membrane proteins such as the GLUT4 and IGF-II and insulin receptors.
Reduction of threshold voltage sensitivity in SOI MOSFET's (1995)

The threshold voltage sensitivity, of fully depleted SOI MOSFET's to variations in SOI silicon film thickness was examined through both simulation and device experiments. The concept of designing the channel V/sub th/ implant to achieve a constant dose within the film, rather than a constant doping concentration, was studied for a given range of film thicknesses. Minimizing the variation in retained dose reduced the threshold voltage sensitivity to film thickness for the range of t/sub si/ examined. One-dimensional process simulations were performed to determine the optimal channel implant condition that would reduce the variation in retained dose using realistic process parameters for both NMOS and PMOS device processes. SOI NMOS transistors were fabricated. The experimental results confirmed the simulation findings and achieved a reduced threshold voltage sensitivity.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inflamed gut mucosa: downstream of interleukin‐10 (2011)

The discovery of inherited deregulations in the IL-10 signalling cascade is not only considered the missing link between IL-10 and intestinal homeostasis, but also demonstrates how findings made in animal models help explaining human disease.
Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf (1996)

Although the involvement of protein kinase C (PKC) in the activation of the mitogen-activated protein (MAP) kinase pathway has been implicated through experiments using 12-O-tetradecanoylphorbol-13-acetate (TPA), there has been no direct demonstration that PKC activates the MAP kinase pathway. A Raf-dependent intact cell assay system for monitoring the activation of MAPK/ERK kinase (MEK) and extracellular signal-related kinase (ERK) permitted us to evaluate the role of PKC isotypes in MAP kinase activation. Treatment of cells with TPA or epidermal growth factor resulted in the activation of MEK and ERK. The activation of the MAP kinase pathway triggered by epidermal growth factor was completely inhibited by dominant-negative Ras (RasN17), whereas the activation triggered by TPA was not, consistent with previous observations. The introduction of an activated point mutant of PKCdelta, but not PKCalpha or PKCepsilon, resulted in the activation of the MAP kinase pathway. The activation of MEK and ERK by an activated form of PKCdelta requires the presence of c-Raf and is independent of RasN17. These results demonstrate that activation of PKCdelta is sufficient for the activation of MEK and ERK and that the pathway operates in a manner dependent on c-Raf and independent of Ras.
Experimental Autoimmune Encephalomyelitis in Mice: Immunologic Response to Mouse Spinal Cord and Myelin Basic Proteins (1975)

Abstract It was confirmed that experimental autoimmune encephalomyelitis EAE, could be induced in SJL/J mice with mouse spinal cord homogenate. It was shown that induction of EAE in mice was critically dependent on the concentration of pertussis vaccine. The encephalitogen present in mouse brain was the basic protein of myelin. The smaller form of the mouse and rat basic proteins induced EAE; thus the mouse like the rat responds to determinants other than the “tryptophan region,” which induces EAE in guinea-pigs. Mice with EAE developed a cell-mediated immune response to myelin basic protein, as judged by inhibition of peritoneal cell migration. However, levels of antibody to mouse basic protein were low, as judged by radioimmunoassay. The establishment of this autoimmune disease model in the mouse will allow the application of well established techniques for the analysis of the immunologic mechanisms leading to disease manifestation.