gebhart/patrepeval huggingface dataset:
cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. (1993)

We report the nucleotide sequence of the mouse ret proto-oncogene (proto-ret) and the deduced amino acid sequence. It encodes a transmembrane tyrosine kinase of 1115 amino acids that shows 83% homology with the human proto-Ret protein. The amino acid sequence revealed that the structures of the extracellular domain as well as the tyrosine kinase domain are similar in human and mouse proto-Ret proteins. Interestingly, the extracellular domains of both human and mouse proto-Ret proteins contain a cadherin-related sequence that is known to be important for Ca(2+)-dependent homophilic binding of the cadherins. When we examined transcription of the proto-ret gene in a variety of mouse tissues, it was detected in lymph nodes of C3H/HeJ-gld/gld mice and in normal mouse spinal cord. Furthermore, its transcription was found in the Neuro-2a mouse neuroblastoma cell line but not in 13 other rodent cell lines surveyed. Western blot analysis showed that proto-Ret proteins are expressed as 140-kDa and 160-kDa glycoproteins in Neuro-2a cells.
MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production (2016)

Pattern recognition receptors are critical for the detection of invading microorganisms. They activate multiple pathways that lead to the induction of proinflammatory responses and pathogen clearance. The intensity and duration of this immune reaction must be tightly controlled spatially and temporally in every tissue by different negative regulators. We hypothesized that monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) might play a role in maintaining immune homeostasis in the epithelium both under physiological conditions and upon bacterial infection. To this end, we examined the distribution of the MCPIP-1 transcript and protein in various tissues. The MCPIP-1 protein level was higher in epithelial cells than in myeloid cells. MCPIP-1 exerted RNase activity towards the interleukin (IL)-8 transcript and the lifespan of IL-8 was determined by the presence of the stem-loops/hairpin structures at the 3'UTR region of IL-8 mRNA. Moreover, using fully active, purified recombinant MCPIP-1 protein, we elucidated the mechanism by which MCPIP-1 controls the IL-8 mRNA level. In conclusion, we uncovered a novel IL-8-dependent mechanism via which MCPIP-1 maintains epithelial homeostasis. This study reveals for the first time that MCPIP-1 plays a crucial anti-inflammatory role not only in myeloid cells but also in epithelial cells.
Murine amyloid protein AA in casein-induced experimental amyloidosis. (1977)

Amyloidosis was induced in mice by 25 subcutaneous injections of casein. The splenic amyloid fibrils were identified by electron microscopy to be closely associated with reticular cells. After isolation of the fibrils by simple physical techniques, their ultrastructure revealed single filaments of 80 to 100 A width, which were rigid, nonbranching, and of indeterminate length. This is comparable to previous studies on human preparations. The amyloid fibrils were dissociated by solution in guanidine and chromatography. The resultant amyloid fibril protein was characterized as to its molecular weight, amino acid analysis, and amino-terminal sequence. It was thus definitely identified as protein AA, the major component of secondary amyloidosis. An antibody to this protein, murine AA, identified a cross-reacting mouse serum protein SAA and indicated a species specificity when tested against human preparations. A comparison is made with the AA protein in another murine model as well as AA proteins from human, guinea pig, monkey, and mink amyloidosis.
Effects of c-myc first exons and 5' synthetic hairpins on RNA translation in oocytes and early embryos of Xenopus laevis. (1996)

Mammalian c-myc transcripts have long G/C-rich 5' untranslated regions (UTRs) that may fold into secondary structural elements that may impede translation. We have examined the effects of different c-myc first exons, which produce most of the 5' UTR of c-myc transcripts, on translation in Xenopus oocytes and embryos, by placing these structures upstream of a chloramphenicol acetyltransferase (CAT) reporter. Our results demonstrate that the human c-myc first exon inhibits reporter translation in both oocytes and embryos. Unlike their mammalian counterparts, Xenopus c-mycI first exons initiated at either promoter 1 or promoter 2 do not impede translation. We conclude that translation inhibition reported in a previous investigation (Lazarus, 1992. Oncogene, 7:1037) utilizing Xenopus c-mycI 5' non-coding elements was due to the inclusion of nonrelevant non-transcribed sequences. Previous investigators have reported that inhibition of translation in Xenopus oocytes by 5' secondary structure is alleviated after fertilization (Lazarus et al., 1988. Oncogene 3:517; Fu et al., 1991, Science 251:807). We repeated the experiments of Fu et al., examining the effects on translation by a highly stable synthetic hairpin. The hairpin severely [correction of severly] restricted translation in both oocytes and embryos, indicating that highly stable 5' secondary structure is equally inhibitory in oocytes and embryos.
The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations (1986)

Single-stranded cDNA clones complementary to the 5' end of TMV RNA have been used to explore the conditions necessary for efficient 'hybrid arrest of translation' in the reticulocyte lysate. It is shown that incubations of 20 minutes at 60 degrees in 0.1 M KCl are sufficient to give almost complete arrest of translation using a clone complementary to the 5'-non-coding region and first 171 coding nucleotides of TMV RNA. However, hybrids with DNA complementary to regions of the mRNA downstream of the first AUG gave variable and in some cases almost no arrest of translation in the reticulocyte lysate unless they were first digested with RNase H. A simple and rapid method for giving complete and highly specific arrest of translation of particular mRNAs in complex mixtures has been developed using both cDNA clones and synthetic oligodeoxynucleotides in conjunction with RNase H digestion. Evidence is presented that suggests that 'hybrid arrest of translation' in the wheat-germ cell-free system is primarily due to the action of RNase H. When a reticulocyte lysate was doped with 20 U/ml of RNase H, its ability to translate unannealed mRNA was unaffected but it translated DNA/RNA hybrids extremely poorly.
Positive Inotropic Effect of Ouabain on Isolated Heart Is Accompanied by Activation of Signal Pathways that Link (2003)

Exposure of cultured rat cardiac myocytes to ouabain is known to cause the interaction of Na + /K + -ATPase with adja- cent proteins, leading to activation of multiple signal transduction pathways, regulation of growth-related genes, and hypertrophy. The aim of this work was to determine if the proximal signaling events identified in cultured myocytes also occur in isolated intact hearts of rat and guinea pig in response to positive inotropic doses of ouabain. Langendorff rat heart preparations were exposed to 50 µM ouabain to produce positive inotropy without toxicity, and assayed for Src kinase, protein kinase C, and extracellular signal- regulated kinases 1 and 2 (ERK1/2). These kinases were rapidly activated by ouabain as in cultured cells. In isolated guinea pig hearts, 1 µM ouabain caused ERK1/2 activation comparable to the effect of 50 µM ouabain in rat heart and consistent with the higher ouabain sensitivity of the contractility of guinea pig heart. These data show that the proximal ouabain-induced signal pathways previously noted in cultured cells are not artifacts of dispersion/culturing of myocytes, and are not the peculiar prop- erties of the rat heart with its relatively low ouabain sensitivity. They also suggest that treatment with positive inotropic doses of cardiac glycosides is likely to be associated with changes in the cardiac phenotype.
The Stick-e Document: a Framework for Creating Context-aware Applications (1996)

There is increasing interest in computer applications that are aware of the user’s context. Currently these applications are normally hand-crafted. A lot of them consist of presenting information to users as they enter a given context, for example a tourist nearing a site within a city or a visitor moving round a building. The paper presents a new form of document, and the supporting software, which allows such applications to be created simply by building a new document. The motivation is to make the creation and use of these applications as easy as creating and using web pages. KEY WORDS Document Context-aware PDA HTML Stick-e 1
Une nouvelle classe de polymeres d'α‐olefines ayant une régularité de structure exceptionnelle (1955)

Abstract Les propriétés exceptionnelles d'une nouvelle classe d'hydrocarbures macromoléculaires à structure linéaire obtenus par polymérisation d'α‐oléfines sont décrites. La haute température de fusion, la cristallinité élevée, la faible solubilité, les propriétés mécaniques spéciales de ces polymères sont attribuées à une régularité particulière de structure due à l'existence, dans chaque macromolécule, de longues successions ordonnées d'atomes de carbone asymétriques ayant la même configuration stérique. Pour ce type particuler d'ordonnement d'atomes de carbone asymétriques dans des macromolécules linéaires, on propose le terme “isotaxique.”
A Possible Role for the High Mobility Group Box Transcription Factor Tcf-4 in Vertebrate Gut Epithelial Cell Differentiation (1999)

The Wingless (Wg)/Wnt signaling pathway activates High Mobility Group (HMG)-box transcription factors of the T-cell Factor (Tcf)/Lymphoid Enhancer Factor (LEF) subfamily and mediates diverse functions in development, possibly including endoderm and gut differentiation. Determinants of tissue specificity in the response to Wg/Wnt signaling remain unknown. We have identified Tcf-4 as the predominant Tcf/LEF factor in the developing mouse gut. During fetal development, Tcf-4 mRNA expression is restricted to gut epithelium and specific regions of the brain, the thalamus and roof of the midbrain. In adults, expression is widespread, with highest levels observed in the liver, an endodermally derived organ, and persists in the gastrointestinal tract. Murine Tcf-4 has multiple RNA splice variants with consequently significant heterogeneity in sequences 3' to the HMG box. Microinjection of mRNA or plasmid DNA encoding Tcf-4 into Xenopus embryos results in ectopic expression of molecular markers of endoderm and differentiated gut epithelium in isolated animal cap explants. Taken together, these findings point to a potentially important function for Tcf-4 in development of the vertebrate gastrointestinal tract.
Estrogen Control of Progesterone Receptor in Human Breast Cancer: Role of Estradiol and Antiestrogen* (1978)

Estrogen antagonists are widely used in the treatment of breast cancer, and studies of their mechanism of action may provide clues to an understanding of tumor growth regulation and mechanisms of normal estrogen action. We have used human breast cancer cells in long term culture as an in vitro model to study the roles of estradiol and the antiestrogens, tamoxifen and nafoxidine, on cell growth and progesterone receptor (PgR) induction. Tamoxifen is found to have dual dose-dependent estrogenic/antiestrogenic properties. With 1 micrometer tamoxifen, cell growth and PgR induction are suppressed. These effects are reversed by estradiol. At lower doses (less than 0.1 micrometer), however, tamoxifen is a potent estrogen and rapidly induces (24--48 h) PgR, which increases 4- to 10-fold after 4--6 days and falls if tamoxifen is removed. Induction of PgR by estradiol is weaker but follows a similar time course. Tamoxifen-induced PgR is similar to that induced by estradiol; it sediments at 8S on sucrose density gradients, is a tight binder (R5020 Kd, 1.7 micrometer at 4 C and 0.87 nM at 15 C), and can be translocated to the nucleus by R5020. The dual properties of tamoxifen are not due to metabolic formation of an active antiestrogen from a prohormone precursor. In contrast, the action of the antiestrogen nafoxidine is not biphasic in MCF-7 cells; it does not induce PgR over a wide dose range and at high doses, the compound inhibits cell growth.
Modeling the Melting Temperature of Nanoparticles by an Analytical Approach (2007)

The dependency of the surface-to-volume coordination number upon particle size has been obtained by an analytical function based upon our previous work, and a model for melting temperature as a function of size is presented. This expression for the melting temperature is a nonlinear relation in terms of the reciprocal of size. Also, the geometrical characteristics of nanoclusters have been applied to our general equation for the melting temperature of nanoparticles. It was found that the results of considering the geometrical characteristics of nanoclusters are in good agreement with the melting temperature achieved by the derived analytical function. Finally, this model has been compared with other theoretical models as well as the available experimental data. The predictions are consistent with the experimental data.
Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: a phase I study. (1999)

A Phase I radioimmunotherapy trial was conducted in which radioconjugated monoclonal antibody (MAb) was directly infused into the tumor or postoperative tumoral bed in patients with high-grade malignant glioma. BC-4, a murine MAb that recognizes tenascin, was used in these studies. The MAb was labeled with 90Y, a pure beta emitter with maximum energy of 2.284 MeV, which can penetrate into tissue up to 0.5-0.7 cm. Stable 90Y-labeled MAb conjugates were prepared using the chelator p-isothiocyanatobenzyl derivative of diethylenetriaminepentaacetic acid (ITC-Bz-DTPA), obtaining >95% labeling efficiency and conserving the antibodies' immunoreactivity (>85%). Twenty patients, 2 with anaplastic astrocytoma and 18 with glioblastoma, were included in the study. All of the patients had been treated previously with conventional therapies (surgery, external radiotherapy, and chemotherapy) and presented with progressive disease not amenable to further treatment. A dose-escalation study was performed using doses ranging from 5-30 mCi (185-1110 MBq) of 90Y-labeled MAb BC-4. The protein dose of MAb was always 1 mg. Three patients were treated at the 5, 10, 15, and 20 mCi levels, and the 25- and 30-mCi doses were each administered to 4 patients. Systemic toxicity was completely absent in all of the patients. The maximum tolerated dose to the brain was 25 mCi (925 MBq). The average dose to the tumor was 3200 cGy/mCi. Doses to the liver, bone marrow, and kidneys were below 10 cGy/mCi in all of the cases. Biodistribution studies demonstrated that the 90Y-labeled MAb accreted exclusively in the neoplastic area without any diffusion into the normal brain or other normal organs. No clinical responses were recorded because of the very advanced stage of disease at the time of radioimmunotherapy.
Scheduling alternative activities (1999)

In realistic scheduling problems, there may be choices among resources or among process plans. We formulate a constraint-based representation of alternative activities to model problems containing such choices. We extend existing constraint-directed scheduling heuristic commitment techniques and propagators to reason directly about the fact that an activity does not necessarily have to exist in a final schedule. Experimental results show that an algorithm using a novel texture-based heuristic commitment technique together with extended edge-finding propagators achieves the best overall performance of the techniques tested.
Configuration for micro pH sensor (2003)

A fully integrated pH sensor with a built-in reference electrode is proposed. An iridium oxide microelectrode and a pH-insensitive field-effect transistor are used as a pH sensor and a reference electrode, respectively. The sensitivity of the proposed device matches well with the estimated value to within 0.3 mV/pH deviation.
Switching iron sucrose to ferric carboxymaltose associates to better control of iron status in hemodialysis patients (2018)

In this real-life study in HD patients, a switch from IS to FCM resulted in an improvement of iron status parameters despite a lower weekly dose of FCM. Furthermore, the ESA dose was reduced during FCM, while hemoglobin levels increased.
Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells (2013)

Our data indicate that triggering of SIRPα has antileukemic effect and may function as a potential therapeutic target in AML.
VIRTUALIZATION TECHNIQUES & TECHNOLOGIES: STATE-OF-THE-ART (2011)

Today virtualization is not just a possibility but it is becoming mainstream in data centers across the business world. Virtualization technology is popular today for hosting Internet and cloud-based computer services. Technology is evolving at a rapid rate and virtualization is no longer just about consolidation and cost savings, It is about the agility and flexibility needed for service delivery in data centers, including production environment and the infrastructure that supports the most mission-critical applications. Virtualization is a rapidly evolving technology that provides a range of benefits to computing systems, such as improved resource utilization and management, application isolation and portability and system reliability. Among these features, live migration, resources management, IT infrastructure consolidation are core functions. Virtualization technology also enables IT personnel to respond to business needs more rapidly with lower cost and improved operational efficiencies. Virtualization technologies are changing the IT delivery model to provide on-demand self-service access to a shared pool of computing resources via broad network. The analysis of this survey will enable a better understanding of basic concept of virtualization, virtualization techniques, technologies, services and motivate especially Information Technologies (IT) staff as a detailed framework for the companies working in different industrial sectors. The evolution of datacenter transformation from traditional approach to virtualization i.e. from dedicated processing to pooled processing with strategic business values and methodologies are analyzed in details in this paper. This paper also discusses what virtualization is, how organizations can benefit from adopting virtualization into future IT plans.
DIME: a programming environment for unstructured triangular meshes on a distributed-memory parallel processor (1988)

DIME (Distributed Irregular Mesh Environment) is a user environment written in C for manipulation of an unstructured triangular mesh in two dimensions. The mesh is distributed among the separate memories of the processors, and communication between processors is handled by DIME; thus the user writes C-code referring to the elements and nodes of the mesh and need not be unduly concerned with the parallelism. A tool is provided for the user to make an initial coarse triangulation of a region, which may then be adaptively refined and load-balanced. DIME provides many graphics facilities for examining the mesh, including contouring and a Postscript hard-copy interface. DIME also runs on sequential machines.
Grouped and Hierarchical Model Selection through Composite Absolute Penalties (2007)

Extracting useful information from high-dimensional data is an important part of the focus of today’s statistical research and practice. Penalized loss function minimiza-tion has been shown to be effective for this task both theoretically and empirically. With the virtues of both regularization and sparsity, the L1-penalized L2 minimization method Lasso has been popular in regression models. In this paper, we combine different norms including L1 to form an intelligent penalty in order to add side information to the fitting of a regression or classification model to obtain reasonable estimates. Specifically, we introduce the Composite Absolute Penal-ties (CAP) family which allows the grouping and hierarchical relationships between the predictors to be expressed. CAP penalties are built by defining groups and com-bining the properties of norm penalties at the across group and within group levels. Grouped selection occurs for non-overlapping groups. In that case, we give a Bayesian 1 interpretation for CAP penalties. Hierarchical variable selection is reached by defining groups with particular overlapping patterns. In the computation aspect, we propose using the BLASSO and cross-validation to obtain CAP estimates. For a subfamily of CAP estimates involving only the L1 and L ∞ norms, we introduce the iCAP algorithm to trace the entire regularization path for the grouped selection problem. Within this subfamily, unbiased estimates of the degrees of freedom (df) are derived allowing the regularization parameter to be selected without cross-validation. CAP is shown to im-prove on the predictive performance of the LASSO in a series of simulated experiments including cases with p&amp;gt;&amp;gt; n and mis-specified groupings. When the complexity of a model is properly calculated, iCAP is seen to be parsimonious in the experiments. 1
The 1944 Education Act and outdoor education: from policy to practice (1999)

(1999). The 1944 Education Act and outdoor education: from policy to practice. History of Education: Vol. 28, No. 2, pp. 157-172.
An Open-Framework Germanate with Polycubane-Like Topology (1999)

Body-centered Ge9 parallelepiped building blocks form the basis of the structure of [Ge9O18(OH)4]⋅2 (H2ppz)⋅0.5 (H2O) (ASU-14, ppz=piperazine). In this new structure type for an open-framework germanate (see picture for a section of the structure) the building blocks are linked together at each of their eight vertices to give the rare polycubane topology with an intersecting channel system of ten- and eight-membered rings (pore sizes 5×6 and 4×4 Å2, respectively) in which the piperazinium cations and water molecules reside.
Improving the Gate Stability of ZnO Thin-Film Transistors with Aluminum Oxide Dielectric Layers (2008)

We report on the fabrication of gate-stable ZnO thin-film transistors (TFTs) with aluminum oxide dielectric. When an off-stoichiometric was deposited at room temperature, the ZnO-TFT revealed unreliable transfer characteristics: a large drain current-gate bias hysteresis and a large amount of threshold voltage shift under gate-bias stress. As rapid thermal annealing (RTA) in ambient was applied onto at prior to ZnO channel deposition, the gate-bias reliability of the ZnO device was improved. The RTA might cause our surface to be more stoichiometric and thus to be resistant against ZnO sputter-induced damage. When the bottom-gate ZnO-TFT was fabricated with a stoichiometric dielectric grown by atomic layer deposition (ALD), our device showed much more stable electrical characteristics than with the sputter-deposited off-stoichiometric . Last, as an ultimate effort to improve the gate reliability, we fabricated a top-gate ZnO-TFT device adopting the same thick ALD-grown stoichiometric as in the bottom-gate device. Our top-gate device with the dielectric then showed no hysteresis and no shift after several times of gate bias sweep. We conclude that both the high quality dielectric and optimized device structure are necessary to realize electrically stable ZnO-TFTs.