gebhart/patrepeval huggingface dataset:
Business Data Communications (1990)

Business Data Communications and Security covers the fundamentals of data communications, networking, distributed applications, and network management and security. These concepts are presented in a way that relates specifically to the business environment and the concerns of business management and staff. While making liberal use of real-world case studies and charts and graphs to provide a business perspective, the book also provides the student with a solid grasp of the technical foundation of business data communications. The diverse set of projects and student exercises enables the instructor to use the book as a component in a rich and varied learning experience and to tailor a course plan to meet the specific needs of the instructor and students. This edition features a new co-author, Dr. Thomas L. Case, Professor and Chair of the Department of Information Systems at Georgia Southern University. New coverage of security-related issues is included in relevant places throughout the book to meet the needs of the IT/IS schools using this book and the growing emphasis on network security. Additionally, the Seventh edition now aligns with the ACM/AIS IS 2010 curriculum model
Connections of Inferior Temporal Areas TEO and TE with Parietal and Frontal Cortex in Macaque Monkeys (1994)

Inferior temporal cortex is perhaps the highest visual processing area and much anatomical work has focused on its connections with other visual areas in temporal and occipital cortex. Here we report connections of inferior temporal cortex with regions in the frontal and parietal lobes. Inferior temporal areas TEO and TE were injected with WGA-HRP and 3H-AA, respectively, or vice versa, in 1-week-old infant and 3-4-year-old adult monkeys (Macaca mulatta). The results indicated that whereas TEO has more extensive connections with parietal areas, TE has more extensive connections with prefrontal areas. Thus, in the intraparietal sulcus, area TEO is connected with areas LIPd, LIPv, and V3A, and with the as yet undefined region between LIPv and V3A, whereas the connections of TE are predominantly with LIPd, and to a lesser extent with LIPv. In the prefrontal cortex, area TE is connected with areas 8 and 45 in the inferior limb of the anterior bank of the arcuate sulcus, with area 12 on the inferior prefrontal convexity, and with areas 11 and 13 on the orbital surface. By contrast, the connections of area TEO are limited to areas 8, 45, and 12. Furthermore, within prefrontal cortex, the projections from areas TEO and TE terminate in different layers in areas 8 and 45, such that those from TEO terminate in all layers, whereas those from TEO terminate in layers I and V/VI only. In contrast to the connections of areas TEO and TE with various medial temporal-lobe and subcortical structures, which are immature in infant monkeys (Webster et al., 1991, 1993b), the connections with parietal and prefrontal areas appear adult-like as early as 1 week of age.
Salicylic Acid Induction-Deficient Mutants of Arabidopsis Express PR-2 and PR-5 and Accumulate High Levels of Camalexin after Pathogen Inoculation (1999)

Christiane Nawrath, , Salicylic Acid Induction-Deficient Mutants of Arabidopsis Express PR-2 and PR-5 and Accumulate High Levels of Camalexin after Pathogen Inoculation, The Plant Cell, Vol. 11, No. 8 (Aug., 1999), pp. 1393-1404
Fractals and cancer. (2000)

Recent studies have shown that fractal geometry, a vocabulary of irregular shapes, can be useful for describing the pathological architecture of tumors and, perhaps more surprisingly, for yielding insights into the mechanisms of tumor growth and angiogenesis that complement those obtained by modern molecular methods. This article outlines the basic methods of fractal geometry and discusses the value and limitations of applying this new tool to cancer research.
Detection and Quantitation of Bacteria in Platelet Products Stored at Ambient Temperature (1973)

A study of bacterial contamination in platelet products stored at ambient temperature demonstrated the presence of bacteria in 2.4 per cent of platelets as determined by culturing platelet pools. The recovery of bacteria increased as storage time prior to culture increased, which suggested bacterial proliferation during storage. While many of the bacteria recovered were normal skin flora, i.e ., diphtheroids and Staphylococcus epidermidis , pathogens such as Enterobacter cloacae, Staphylococcus aureus , and Pseudomonas spp. were recovered several times. Quantitative cultures were performed in the present study which demonstrated that most pools contained relatively few microorganisms, although some harbored more than 500 bacteria/ml after ambient temperature storage. The introduction of microorganisms during the pooling procedure can not be ruled out. Of 3,251 units not subjected to pooling, 45 (1.4%) were found to contain bacteria. Platelets kept at ambient temperature for 11 to 71 days were cultured and 38 of 631 (6.0%) individual units contained bacteria. Four additional severe patient reactions and two deaths have occurred consequent to transfusion of platelets contaminated with bacteria. These observations lead to the conclusion that caution should be exercised in the use of platelets stored at ambient temperature.
Transcription factors and their genes in higher plants (1999)

A typical plant transcription factor contains, with few exceptions, a DNA-binding region, an oligomerization site, a transcription-regulation domain, and a nuclear localization signal. Most transcription factors exhibit only one type of DNA-binding and oligomerization domain, occasionally in multiple copies, but some contain two distinct types. DNA-binding regions are normally adjacent to or overlap with oligomerization sites, and their combined tertiary structure determines critical aspects of transcription factor activity. Pairs of nuclear localization signals exist in several transcription factors, and basic amino acid residues play essential roles in their function, a property also true for DNA-binding domains. Multigene families encode transcription factors, with members either dispersed in the genome or clustered on the same chromosome. Distribution and sequence analyses suggest that transcription factor families evolved via gene duplication, exon capture, translocation, and mutation. The expression of transcription factor genes in plants is regulated at transcriptional and post-transcriptional levels, while the activity of their protein products is modulated post-translationally. The purpose of this review is to describe the domain structure of plant transcription factors, and to relate this information to processes that control the synthesis and action of these proteins.
Higher Yielding Perennials Point the Way to New Crops (1996)

Today, almost all of our major crops are herbaceous annuals—plants such as corn and soybeans that have to be replanted every year. These plants have a big advantage: They produce masses of seeds. Recent results from a few agricultural pioneers suggest, however, that it is possible to boost dramatically the seed yields of at least some perennials, including cousins to corn and wheat. These studies may eventually lead to new, more environmentally friendly crops.
Functional analysis reports. Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction (1995)

We adapted a fusion polymerase chain reaction (PCR) strategy to synthesize gene disruption alleles of any sequenced yeast gene of interest. The first step of the construction is to amplify sequences flanking the reading frame we want to disrupt and to amplify the selectable marker sequence. Then we fuse the upstream fragment to the marker sequence by fusion PCR, isolate this product and fuse it to the downstream sequence in a second fusion PCR reaction. The final PCR product can then be transformed directly into yeast. This method is rapid, relatively inexpensive, offers the freedom to choose from among a variety of selectable markers and allows one to construct precise disruptions of any sequenced open reading frame in Saccharomyces cerevisiae.
High Mobility Organic Field-Effect Transistors from Majority Insulator Blends (2016)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTHigh Mobility Organic Field-Effect Transistors from Majority Insulator BlendsMichael J. Ford†‡⊥, Ming Wang‡⊥§, Shrayesh N. Patel⊥∥, Hung Phan‡⊥§, Rachel A. Segalman†⊥∥, Thuc-Quyen Nguyen‡⊥§, and Guillermo C. Bazan*†‡⊥§View Author Information† ‡ ⊥ § †Materials Department, ‡Center for Polymers and Organic Solids, ⊥Mitsubishi Chemical Center for Advanced Materials, §Department of Chemistry and Biochemistry, ∥Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California 93106, United States*G. C. Bazan. E-mail: [email protected]Cite this: Chem. Mater. 2016, 28, 5, 1256–1260Publication Date (Web):February 4, 2016Publication History Received9 December 2015Revised29 January 2016Published online12 February 2016Published inissue 8 March 2016https://pubs.acs.org/doi/10.1021/acs.chemmater.5b04774https://doi.org/10.1021/acs.chemmater.5b04774rapid-communicationACS PublicationsCopyright © 2016 American Chemical SocietyRequest reuse permissionsArticle Views3776Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Insulators,Polymers,Porous materials,Silicon,Thin films Get e-Alerts
Chemical Constituents of Acacia catechu Leaves (1997)

Chemistry Division, Forest Research Institute. Dehradun-248 006 <em>Manuscript received 28 October 1994. revised </em>5 <em>May 1995 accepted 20 July 1995</em> Chemical Constituents of <em>Acacia catechu</em> Leaves
Benzisoxazole- and Benzisothiazole-3-carboxamides as Potential Atypical Antipsychotic Agents (1994)

A series of benzisoxazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D2 and serotonin 5HT2A and 5HT1A receptors. Several members of this series have demonstrated activity in animal models predictive of potential antipsychotic activity. In addition, compounds 18, 19, 22, 27, 28, 43, and 44 have also shown a potential for reduced EPS liability as suggested by the ratio of activity seen in mesolimbic-mediated vs nigrostriatal-mediated behavioral assays.
Synthesis of Oat Globulin Precursors (1982)

The oat (Avena sativa L.) seed globulin was found to be synthesized in vitro as 60,000 to 64,000 dalton precursors. In vivo protein labeling yielded polypeptides of 58,000 to 62,000 daltons, suggesting cleavage of signal sequences from the precursors. Further cleavage is apparently required to separate the alpha and beta polypeptide sequences which are known to form disulfide-linked 53,000 to 58,000 dalton species in the (alphabeta)(6) holoprotein. The data are discussed with respect to analogous synthesis and processing of some legume 11S storage proteins.
Potent Retinoid Synergists with a Diphenylamine Skeleton. (1998)

4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M) in the presence of 1.0 x 10(-10) M Am80 (2).
Overhauling Rdist for the '90s (1992)

The rdist program was first released as part of 4.3BSD UNIX. It was one of the first programs to address the area of automated software distribution in a timely, consistent manner in a highly distributed environment. Since its first release it has gained very wide use on almost every major UNIX platform. Despite all of its initial advances, rdist has some deficiencies which have not been addressed in any public release of the software until now. This paper describes the past, present, and future of rdist. The program’s history, operation, comparisons to other similar packages, and a number of possible future improvements in performance and functionality are described. A detailed description of rdist version 6, a major new version of the software that will be included in 4.4BSD, is presented. Version 6 rdist addresses many of the deficiencies of the original rdist, including significantly improved performance when updating large numbers of hosts, better error handling and avoidance, improved security, and cleanup of the actual source code.
Structural characterization of VGVAPG, an elastin‐derived peptide (2004)

Elastic fibers are an important component of the extracellular matrix, providing elasticity and resilience to tissues that require the ability to deform repetitively and reversibly. Among the elastin-derived peptides, the Val-Gly-Val-Ala-Pro-Gly (VGVAPG) hexapeptide is known for its chemotactic activity and metalloproteinases upregulation properties. As other elastin-derived peptides, having homologous similar sequences, do not exhibit any biological activity, the following question arises: Does the peptide-receptor interaction need a specific active conformation? Previous experimental studies including NMR and CD spectroscopies did not clearly identify the conformations adopted by the VGVAPG peptide in solution. However, structural predictions made on VGVAPG and related XGXXPG peptides suggested a folded beta-turn conformation. So we undertook a theoretical and experimental study of the VGVAPG peptide. The work presented here, which gives an overall structural description of VGVAPG behavior in water, also provides an additional insight into its structure-activity relationship. Both theoretical and experimental results suggest the existence of an ensemble of rather extended and folded conformations in solution. All the folded structures obtained exhibit a type VIII beta-turn spanning the GVAP sequence. In the lack of any structural information concerning the elastin receptor, these results suggest that such a conformation could be relevant for the peptide-receptor interaction and thus for biological activity.
Protein Modification in Aging (1988)

The age-related accumulation of abnormal forms of enzymes is attributable to posttranslational modification of protein structure and to a progressive loss with age of proteases that preferentially degrade the modified forms. The protein modifications include, but are not limited to: the oxidation of amino acid side chains (especially, side chains of prolyl, arginyl, lysyl and histidinyl residues) by mixed-function oxidation systems; the deamidation of asparaginyl and glutaminyl residues; the racemization and isomerization of aspartyl and asparaginyl residues; the isomerization of prolyl residues; the oxidation of cysteine sulfhydryl groups; and spontaneous changes in protein conformation that are apparently unlinked to changes in amino acid composition. Evidence supporting the roles of these protein modifications and of the proteases that degrade abnormal enzymes during aging is discussed, as well as a consideration of some technical limitations of the methods used in their study.
RNA-Seq Analysis of Microglia Reveals Time-Dependent Activation of Specific Genetic Programs following Spinal Cord Injury (2017)

Neurons have inherent competence to regrow following injury, although not spontaneously. Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by resident microglia and infiltrating peripheral macrophages. Microglia are the first reactive glial population after SCI and participate in recruitment of monocyte-derived macrophages to the lesion site. Both positive and negative influence of microglia and macrophages on axonal regeneration had been reported after SCI, raising the issue whether their response depends on time post-lesion or different lesion severity. We analyzed molecular alterations in microglia at several time-points after different SCI severities using RNA-sequencing. We demonstrate that activation of microglia is time-dependent post-injury but is independent of lesion severity. Early transcriptomic response of microglia after SCI involves proliferation and neuroprotection, which is then switched to neuroinflammation at later stages. Moreover, SCI induces an autologous microglial expression of astrocytic markers with over 6% of microglia expressing glial fibrillary acidic protein and vimentin from as early as 72 h post-lesion and up to 6 weeks after injury. We also identified the potential involvement of DNA damage and in particular tumor suppressor gene <i>breast cancer susceptibility gene 1</i> (<i>Brca1</i>) in microglia after SCI. Finally, we established that BRCA1 protein is specifically expressed in non-human primate spinal microglia and is upregulated after SCI. Our data provide the first transcriptomic analysis of microglia at multiple stages after different SCI severities. Injury-induced microglia expression of astrocytic markers at RNA and protein levels demonstrates novel insights into microglia plasticity. Finally, increased microglia expression of BRCA1 in rodents and non-human primate model of SCI, suggests the involvement of oncogenic proteins after CNS lesion.
Advances in synthetic siRNA delivery. (2010)

The application of RNA interference-based gene silencing technologies has the potential to treat a variety of illness. Preclinical studies and some early clinical trials have already demonstrated the utility of small interfering RNAs (siRNAs) as a potential novel therapy for the treatment of cancer, viral infections, as well as a wide range of additional diseases. To be effective, an siRNA must be taken up by specific cells, enter the cytoplasm, and be loaded onto the Argonaute protein, the catalytic core of the RNA induced silencing complex (RISC) to direct the cleavage of the homologous transcripts. To meet this need, a variety of novel siRNA delivery strategies have been developed. As our understanding of the molecular mechanisms underlying the RNAi pathway has increased so has the ability to rationally design effective silencing and delivery strategies. This review will examine the latest advances in non-viral delivery of siRNA, with special reference to targeted siRNA delivery to specific target tissues and cell types in vivo in preclinical animal models.
Evaluation of magnetic recording detection schemes for thin film media (1991)

The authors compare the error rate of fixed-delay tree-search with decision-feedback (FDTS/DF) against that of decision feedback equalization (DFE) and discrete-time peak detection (DPD). The authors begin with a description of the specific forms of FDTS/DF, DFE, and DPD, particularly the respective equalizer design used in this experiment. The data collection system is then described. Error rates from actual disk data are compared with those predicted by measuring the channel step response and assuming linear superposition holds. Error rate measurements were performed on pseudo-random
Evaluation of Biolog for identification of members of the family Micrococcaceae (1993)

The Biolog Identification System (Biolog, Inc., Hayward, Calif.) was challenged at two separate laboratories with 113 coded isolates, including 33 type strains of staphylococci, 5 strains of Micrococcus spp., and 1 strain of Stomatococcus mucilaginosus. Test parameters between the sites were controlled as much as possible. Discrepancies were arbitrated by using conventional biochemicals. Overall accuracies (correct to the species level) upon initial testing were 47.7 and 59.3%, respectively, at the two laboratories. After repeat testing of isolates generating "no identification" responses or errors, the overall accuracies increased to 69.0 and 74.3% at the two sites, respectively, revealing no significant difference in the final results at the two laboratories (78 of 113 versus 84 of 113; P > 0.05). Error rates were 7.1% at one site and 9.7% at the other. The Biolog is not yet accurate enough to serve as a primary method for identifying staphylococci.
The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer (2014)

These results strongly support further investigation of hypomethylating strategies in platinum-resistant ovarian cancer. Specifically, SGI-110 in combination with conventional and/or targeted therapeutics warrants further development in this setting.
Device and Integration Technology for Silicon Photonic Transmitters (2011)

The device and integration technology for silicon photonic transmitters are reviewed in this paper. The hybrid silicon platform enables on-chip lasers to be fabricated with silicon photonic circuits and can be integrated in the CMOS back-end flow. Laser arrays from multiple die bonding and quantum well intermixing techniques are demonstrated to extend the spectral bandwidth from the laser array of the transmitter. Two modulator technologies, silicon modulators and hybrid silicon modulators, are also described.
How to Interpret a Genome-wide Association Study (2008)

Genome-wide association (GWA) studies use high-throughput genotyping technologies to assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to clinical conditions and measurable traits. Since 2005, nearly 100 loci for as many as 40 common diseases and traits have been identified and replicated in GWA studies, many in genes not previously suspected of having a role in the disease under study, and some in genomic regions containing no known genes. GWA studies are an important advance in discovering genetic variants influencing disease but also have important limitations, including their potential for false-positive and false-negative results and for biases related to selection of study participants and genotyping errors. Although these studies are clearly many steps removed from actual clinical use, and specific applications of GWA findings in prevention and treatment are actively being pursued, at present these studies mainly represent a valuable discovery tool for examining genomic function and clarifying pathophysiologic mechanisms. This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance.