gebhart/patrepeval huggingface dataset:
Tumor-Infiltrating Lymphocytes Exhibiting High Ex Vivo Cytolytic Activity Fail to Prevent Murine Melanoma Tumor Growth In Vivo (1998)

The identification of tumor-associated Ags recognized by CD8+ CTL and prevention of tumor outgrowth by adoptive transfer of these CTL demonstrates that CD8+ T cells play a major role in antitumor immunity. We have generated B16.F10 melanoma cells that express the glycoprotein epitope amino acid 33-41 (GP33) of the lymphocytic choriomeningitis virus (LCMV) to examine antitumor CD8+ T cell response in C57BL/6 mice immune to LCMV and in mice transgenic for the LCMV GP33-specific P14 TCR (P14 TCR mice). We find that B16.F10GP33 tumor cells grew in syngeneic C57BL/6 mice without inducing T cell tolerance. LCMV infection or adoptive transfer of LCMV-specific effector T cells delayed but did not prevent growth of preestablished tumors in these mice. However, B16.F10GP33 tumor cells were rejected in mice immune to LCMV and in mice treated with LCMV-specific effector T cells on the same day as the tumor. Surprisingly, B16.F10GP33 tumor cells grew in P14 TCR transgenic mice despite an abundance of tumor-associated Ag-specific CD8+ T cells. In these mice, freshly isolated tumor-infiltrating lymphocytes exhibited an activated phenotype and displayed high GP33-specific cytolytic activity when assessed ex vivo. Thus, B16.F10GP33 melanoma cells are able to initiate, but not to sustain, a GP33-specific CTL response sufficient to clear the tumor enduringly.
Involvement of Recombination Genes in Growth and Viability of Escherichia coli K-12 (1971)

We have studied the growth properties of 17 isogenic strains of Escherichia coli K-12 differing only in the recA, recB, recC , and sbcA alleles. We have observed the following. (i) All recombination deficient strains have decreased growth rates and decreased viabilities compared with recombination proficient strains. The large populations of nonviable cells in Rec − cultures may arise by spontaneous lethal sectoring (9). (ii) A recA mutant strain which is entirely recombination deficient and which shows high ultraviolet sensitivity and “reckless” deoxyribonucleic acid (DNA) breakdown has approximately the same growth rate and twice the viability as recB and recC mutant strains which have residual recombination proficiency, moderate ultraviolet sensitivity, and “cautious” DNA breakdown. (iii) Indirectly suppressed ( sbcA − ) recombination proficient (Rec + ) revertants of recB and recC mutant strains have approximately normal growth rates and are three times as viable as their Rec − ancestors (but not as viable as rec + cells). We suggest the following hypothesis to account for the low viability of Rec − E. coli . Single-strand breaks in the DNA duplex, necessary for normal bacterial growth, may be repaired in a Rec + cell. Failure of Rec − cells to repair this normal DNA damage may lead to the observed loss of viability.
Informe APEI sobre movilidad (2011)

APEI report on mobile web. Contents: 1: In a context of mobility. 2: The web goes mobile. 3: A brief tour today. 4: Mobile devices. 5: Operating systems and mobile browsers. 6: Connectivity. 7: The mobile web standards. 8: Content for the mobile web. 9: Web and mobile libraries. 10: The application model. 11: Geo. 12: Two-dimensional codes. 13: Augmented Reality. 14: Other uses of mobile devices. 15: Bibliography. 16: Tools for the mobile web.
SENSIM: A simulation program for solid-state pressure sensors (1982)

A simulation program is described which is capable of calculating the output response of silicon piezoresistive or capacitive pressure sensors as a function of both pressure and temperature. A thermoelastic plane-stress formulation is used in calculating the stress and deflection of the transducer diaphragm. Both analytical and finite-difference solution methods are available, depending on the sensor structure. Diaphragm thickness taper, oxide and package stress, and rim effects are simulated. For capacitive structures, the program accurately predicts the diaphragm deflection and pressure sensitivity as a function of pressure and temperature. Stepped diaphragm structures are shown to be capable of improving pressure sensitivity by as much as 50 percent. The package-induced thermal drift for electrostatically sealed glass-silicon devices is typically less than 0.05 mmHg/°C.
Novel LiCoO2 Cathode Material with Al2O3 Coating for a Li Ion Cell (2000)

A high-performance LiCoO2 cathode was successively fabricated by a sol−gel coating of Al2O3 to the LiCoO2 particle surfaces and subsequent heat treatment at 600 °C for 3 h. Unlike bare LiCoO2, the Al2O3-coated LiCoO2 cathode exhibits no decrease in its original specific capacity of 174 mA h/g (vs lithium metal) and excellent capacity retention (97% of its initial capacity) between 4.4 and 2.75 V after 50 cycles. A similar excellent capacity retention of the coated LiCoO2 is also observed in a Li ion cell (C/LiCoO2). This is because the high concentration of Al atoms at the particle surface region leads to the enhancement of structural stability of LiCoO2 during cycling, which originates from the disappearance of the phase transition from a hexagonal to monoclinic phase.
Statistical language modeling using the CMU-cambridge toolkit (1997)

The CMU Statistical Language Modeling toolkit was released in 1994 in order to facilitate the construction and testing of bigram and trigram language models. It is currently in use in over 40 academic, government and industrial laboratories in over 12 countries. This paper presents a new version of the toolkit. We outline the conventional language modeling technology, as implemented in the toolkit, and describe the extra e ciency and functionality that the new toolkit provides as compared to previous software for this task. Finally, we give an example of the use of the toolkit in constructing and testing a simple language model.
Solubility of carbon dioxide in molten alkali halides and nitrates and their binary mixtures (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of carbon dioxide in molten alkali halides and nitrates and their binary mixturesEizo Sada, Shigeo Katoh, Hidehumi Yoshii, Ikuo Takemoto, and Naofumi ShiomiCite this: J. Chem. Eng. Data 1981, 26, 3, 279–281Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/je00025a017https://doi.org/10.1021/je00025a017research-articleACS PublicationsRequest reuse permissionsArticle Views311Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Revisiting hybrid and GMM-HMM system combination techniques (2013)

In this paper we investigate techniques to combine hybrid HMM-DNN (hidden Markov model - deep neural network) and tandem HMM-GMM (hidden Markov model - Gaussian mixture model) acoustic models using: (1) model averaging, and (2) lattice combination with Minimum Bayes Risk decoding. We have performed experiments on the “TED Talks” task following the protocol of the IWSLT-2012 evaluation. Our experimental results suggest that DNN-based and GMM-based acoustic models are complementary, with error rates being reduced by up to 8% relative when the DNN and GMM systems are combined at model-level in a multi-pass automatic speech recognition (ASR) system. Additionally, further gains were obtained by combining model-averaged lattices with the one obtained from baseline systems.
Sympathetically maintained pain (1999)

Leriche’s report1 during World War I that periarterial sympathectomy relieves pain in soldiers with nerve injury popularized the hypothesis that sympathetic efferent activity in some way augments chronic pain, and launched a series of sympathoablative treatments that remain in common use today. United States physicians carry out approximately 43,000 sympathetic nerve blocks per year for the treatment of pain.2 Blocks that result in pain relief prompt more permanent interruption of the sympathetic chain by surgery, by injection of neurolytic agents, or by thermocoagulation. The diagnosis in most of these patients is reflex sympathetic dystrophy (RSD), more recently termed complex regional pain syndrome (CRPS) type I, consisting of pain, allodynia, or hyperalgesia disproportionate to the inciting injury and edema, changes in skin blood flow, or abnormal sudomotor activity in the painful region; or causalgia caused by a peripheral nerve injury, now termed CRPS type II.3

The rationale for sympathoablative treatments was strengthened in the 1980s by animal studies showing that sympathetic efferent activity may augment pain in models of both nerve injury and inflammation, and that anatomic changes, such as increased densities of axonal adrenergic receptors or sympathetic fiber sprouting into dorsal root ganglia, may underlie sympathetically maintained pain after nerve injury.4

As the field of pain research has matured, there have been critiques of the “sympathetic hypothesis.” Raja et al.5 pointed out that only some patients with nerve injury or RSD respond to sympathetic nerve blockade, and they proposed that patients’ pain be defined as “sympathetically maintained” or “sympathetically independent” according to their response to temporary sympathetic nerve block. They also criticized local anesthetic blocks of the sympathetic ganglion as being invasive, difficult to blind, and confounded by a large …
Magnetic mesa structures fabricated by reactive ion etching with CO/NH3/Xe plasma chemistry for an all-silicon quantum computer (2005)

Micromachining of magnetic materials is becoming a crucial technology for future magnetic systems/devices such as high-density magnetic recording heads, high-density patterned media, magnetic quantum devices, and micro-magnetic smart systems. NiFe alloy, one of the typical ferromagnetic materials, can be deposited and fabricated using current thin film and micromachining technologies, and it has found various applications in microsensors, microactuators, and microsystems. In our recent work, Ni45Fe55 alloy with the highest saturation magnetic-flux density was selected as the micro-magnet for an all-silicon quantum computer. The micro-magnet was designed to create a large magnetic field gradient and to distinguish 29Si nuclear spins arranged as chains in a 28Si matrix with Larmor frequencies. This paper reports the micromachining of a Ni45Fe55 alloy mesa structure for an all-silicon quantum computer and the preliminary evaluation of its effectiveness using a magnetic force microscope (MFM) and a superconducting quantum interference device (SQUID).
<title>Wavelength tuning and multiple-wavelength generation using a reflection-type liquid crystal spatial light modulator</title> (2001)

A reflection-type spatial light modulator using twisted nematic (TN) liquid crystal (the liquid crystal pixel mirror or LCPM) is employed to realize a new type of digitally tunable, narrow line-width (less than 0.1 nm, instrument-limited), multi-wavelength semiconductor laser. The laser is based on a novel folded telescopic grating-loaded external cavity with LCPM at the focal plane of the folded telescope. With a 50-pixel LCPM, the single wavelength digitally tunable range of a visible laser diode was from 650.8 to 661.24 nm in 0.21 nm steps by biasing the individual pixels. Further, the wavelength can be switched and reset with a response time of 13.6 ms. By biasing two pixels at the same time, obtain dual-wavelength output with the wavelength tunable from 0.21 to 10.4 nm. Generation of tunable triple wavelengths with equal or arbitrary wavelength separation are also demonstrated. Preliminary results on such a laser operating at 1550 nm is also shown.
Industrial-scale production and purification of a heterologous protein in Lactococcus lactis using the nisin-controlled gene expression system NICE: The case of lysostaphin (2005)

This is the first example that shows that nisin-regulated gene expression in L. lactis can be used at industrial scale to produce large amounts of a target protein, such as lysostaphin. Downstream processing was simple and in a few steps produced a highly purified and active enzyme.
Class I MHC-restricted recognition of cells expressing a gene encoding a 41 amino acid product of the influenza hemagglutinin. (1988)

Class I H-2Kd-restricted influenza hemagglutinin (HA)-specific CTL recognize two immuno-dominant sites as represented by synthetic peptides spanning epitopes located in the HA1 and hydrophobic transmembrane domains of the influenza HA. Using a vaccinia virus recombinant expression system, we have examined CTL recognition of HA deletion mutants expressed in target cells. We have demonstrated that a truncated influenza HA gene encoding only the transmembrane anchor region containing a class I recognition site and a short segment of the cytoplasmic tail of the HA can be efficiently presented to class I CTL. These results set the stage for detailed analyses of the intracellular events associated with Ag presentation to class I CTL and offer novel possibilities for future vaccine design.
Empirical modelling of human gaits for bipedal robots (2007)

Modelling of human motion through a discrete sequence of motion primitives, retaining elements of skillful or unique motion of an individual is addressed. Using wireless inertial motion sensors, a skeletal model of the fluid human gait was gathered. The posture of the human model is described by nine sets of euler angles for each sample. An intrinsic classification algorithm known as Minimum Message Length encoding (MML) is deployed to segment the stream of data and subsequently formulate certain Gaussian Mixture Models (GMM) that contain a plausible range of motion primitives. The removal of certain less seemingly important modes has been shown to significantly affect the fluidity of a gait cycle. The approach is described and the outcomes so far are provided. 1
Optical Power of the Isolated Human Crystalline Lens (2008)

The lens power decreases with age, due mainly to a decrease in the contribution of the gradient. The use of a constant equivalent refractive index value to calculate lens power with the lens maker formula will underestimate the power of young lenses and overestimate the power of older lenses.
Synthesis of (-)-shikimate and (-)-quinate 3-phosphates by differentiation of the hydroxyl functions of (-)-shikimic and (-)-quinic acids (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (-)-shikimate and (-)-quinate 3-phosphates by differentiation of the hydroxyl functions of (-)-shikimic and (-)-quinic acidsLatifa Chahoua, Michel Baltas, Liliane Gorrichon, Pierre Tisnes, and Chantal ZeddeCite this: J. Org. Chem. 1992, 57, 21, 5798–5801Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/jo00047a049https://doi.org/10.1021/jo00047a049research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Flavonoids의 약리작용(I) -Flavonoies 구조와 과민반응 억제작용과의 상관성- (1990)

The activities of twenty-one flavonoids and their related compounds on the hypersensitivity reaction against various antigens were studied in vitro...
Chitosan‐based injectable hydrogel as a promising in situ forming scaffold for cartilage tissue engineering (2013)

Chitosan-beta glycerophosphate-hydroxyethyl cellulose (CH-GP-HEC) is a biocompatible and biodegradable scaffold exhibiting a sol-gel transition at 37°C. Chondrogenic factors or mesenchymal stem cells (MSCs) can be included in the CH-GP-HEC, and injected into the site of injury to fill the cartilage tissue defects with minimal invasion and pain. The possible impact of the injectable CH-GP-HEC on the viability of the encapsulated MSCs was assessed by propidium iodide-fluorescein diacetate staining. Proliferation of the human and rat MSCs was also determined by MTS assay on days 0, 7, 14 and 28 after encapsulation. To investigate the potential application of CH-GP-HEC as a drug delivery device, the in vitro release profile of insulin was quantified by QuantiPro-BCA™ protein assay. Chondrogenic differentiation capacity of the encapsulated human MSCs (hMSCs) was also determined after induction of differentiation with transforming growth factor β3. MSCs have very good survival and proliferative rates within CH-GP-HEC hydrogel during the 28-day investigation. A sustained release of insulin occurred over 8 days. The CH-GP-HEC hydrogel also provided suitable conditions for chondrogenic differentiation of the encapsulated hMSCs. In conclusion, the high potential of CH-GP-HEC as an injectable hydrogel for cartilage tissue engineering is emphasised.
Editorial Vol.23 (2013)

TEORÍA Y PRAXIS No. 23, Junio-Diciembre 2013; 1-2
Temperature-Controlled Regioselectivity in the Reductive Cleavage of p-Methoxybenzylidene Acetals (2004)

The regioselective ring opening of pyranosidic 4,6-p-methoxybenzylidene acetals with BH(3)/Bu(2)BOTf in THF can be tuned by adjusting the reaction temperature and reagent concentrations. Reductive cleavage at 0 degrees C resulted in the exclusive formation of 4-O-p-methoxybenzyl (PMB) ethers, whereas reaction at -78 degrees C produced 6-O-PMB ethers in high yields. The latter condition was observed to be compatible with a variety of acid-sensitive functional groups, including allyl and enol ethers. The presence of water does not interfere with reductive ring opening and may contribute toward in situ generation of H(+) as a catalyst for 6-O-PMB ether formation. Reductive cleavage under rigorously aprotic conditions is greatly decelerated, and yields only the 4-O-PMB ether. The temperature-dependent reductive cleavage of the 4,6-acetal can be described in terms of kinetic versus thermodynamic control: Lewis-acid coordination of the more accessible O-6 is favored at higher temperatures, whereas protonation of the more basic but sterically encumbered O-4 predominates at low temperatures.
The Sall2 Transcription Factor Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons (2008)

Nerve growth factor (NGF) regulates the functions of neurons by binding the p75 neurotrophin receptor (p75NTR) and TrkA receptors. It is shown here that it has been found that the Sall2 transcription factor forms a complex with p75NTR. NGF dissociates Sall2 from p75NTR and also activates TrkA, which promotes translocation of Sall2 into the nucleus. Nuclear Sall2 activates target genes that modulate the growth and development of neurons. Thus, one way that p75NTR and TrkA can modulate the functions of neurons is by regulating the localization and actions of Sall2.
Isolation and x-ray crystal structure of the tetrameric lithium-coordinated .alpha.-sulfonimidoyl carbanion [(Me3Si)CH[S(O)(NSiMe3)]Li]4: the first structure of an .alpha.-SO substituted lithium alkyl having no external donor ligands (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and x-ray crystal structure of the tetrameric lithium-coordinated .alpha.-sulfonimidoyl carbanion [(Me3Si)CH[S(O)(NSiMe3)]Li]4: the first structure of an .alpha.-SO substituted lithium alkyl having no external donor ligandsHans Joachim Gais, Uwe Dingerdissen, Carl Krueger, and Klaus AngermundCite this: J. Am. Chem. Soc. 1987, 109, 12, 3775–3776Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/ja00246a041https://doi.org/10.1021/ja00246a041research-articleACS PublicationsRequest reuse permissionsArticle Views92Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Predictors of self-perceived competency in cancer screening examinations. (2002)

Student hands-on experience is crucial in the development of cancer screening competency.