gebhart/patrepeval huggingface dataset:
Collection of Vehicle Activity Data by Video Detection for Use in Transportation Planning (2000)

Advanced traffic management systems allow video image detection to supplement and improve data inputs in transportation modeling efforts. Video detection systems use machine vision technology, the interaction of video cameras, and specialty computer hardware and software to measure traffic. Traffic parameters such as hourly flows, density, vehicle speed, level of service, and other parameters derived from measured and default values are automatically computed. However, the accuracy of video image detection systems is dependent upon factors such as the camera height, location, and angle above the roadway. Environmental factors such as rain, sun intensity, and day/night also affect vehicle detection accuracy. Existing transportation models can benefit from video image detection technology and improved travel demand models can be developed from such data, providing video detection is accurate. This paper examines how transportation models can benefit from video data. A commercially available system is used to collect data from freeway segments in Atlanta, Georgia. The detected vehicle counts, classifications, and average speeds are compared to true counts obtained over the same interval. Differences in these traffic parameters are determined as a function of camera location and site conditions that constrain the accuracy of video detection. The analytical results lead to recommendations on use of video detected traffic parameters in model improvement.
Increasing vigilance on the medical/surgical floor to improve patient safety (2007)

This study demonstrates the accuracy and precision of the signal processing algorithms in the (L)G(1TM) system. Future work will focus on assessing the system's impact on patient outcomes and its integration into the nursing workflow.
A New Phenacyl-Type Handle for Polymer Supported Peptide Synthesis (1985)

A new phenacyl-type handle, [4-(2-bromopropionyl)phenoxy]acetic acid (PPOA, 4) is introduced for polymer supported peptide synthesis. The new anchoring system is easily accessible for synthesis, and PPOA-anchored peptides are readily split off by nucleophiles and photolytic reaction.
A Recombinant Protein of Two High Molecular Weight Glutenins Alters Gluten Polymer Formation in Transgenic Wheat (1997)

Wheat high molecular weight glutenin subunits (HMW-GS) are the most important determinants of its superiority for making leavened bread. Following synthesis, these proteins are sequestered into the endoplasmic reticulum and assemble into extremely large elastic polymers, linked by noncovalent and intermolecular disulfide bonds. To study the structural requirements for the assembly of HMW-GS, we have expressed in transgenic wheat a recombinant protein between two cognate x- and y-type subunits. In contrast to the natural polymerized x- and y-type HMW-GS, a significant amount of the recombinant subunit remained monomeric. Nonreducing SDS-polyacrylamide gel electrophoresis, coupled with limited proteolysis, showed that the monomeric form of the recombinant subunit contained an unusual intramolecular disulfide bond, linking an N-terminal cysteine to the single C-terminal cysteine residue. In addition, sucrose gradient analysis revealed that this intramolecular disulfide bond impeded the ability of the recombinant subunit to assemble into polymers. Despite of its altered assembly, a notable amount of the overexpressed recombinant subunit was also present in glutenin polymers. Moreover, its presence significantly altered the subunit composition of the polymer. Our results show that it is possible to modify gluten assembly and properties by expressing recombinant HMW-GS in transgenic wheat, and have a major implication for the improvement of wheat bread-making quality.
The role of neutrophils in myocardial ischemia–reperfusion injury (1999)

Reperfusion of ischemic myocardium is necessary to salvage tissue from eventual death. However, reperfusion after even brief periods of ischemia is associated with pathologic changes that represent either an acceleration of processes initiated during ischemia per se, or new pathophysiological changes that were initiated after reperfusion. This 'reperfusion injury' shares many characteristics with inflammatory responses in the myocardium. Neutrophils feature prominently in this inflammatory component of postischemic injury. Ischemia-reperfusion prompts a release of oxygen free radicals, cytokines and other proinflammatory mediators that activate both the neutrophils and the coronary vascular endothelium. Activation of these cell types promotes the expression of adhesion molecules on both the neutrophils and endothelium, which recruits neutrophils to the surface of the endothelium and initiate a specific cascade of cell-cell interactions, leading first to adherence of neutrophils to the vascular endothelium, followed later by transendothelial migration and direct interaction with myocytes. This specific series of events is a prerequisite to the phenotypic expression of reperfusion injury, including endothelial dysfunction, microvascular collapse and blood flow defects, myocardial infarction and apoptosis. Pharmacologic therapy can target the various components in this critical series of events. Effective targets for these pharmacologic agents include: (a) inhibiting the release or accumulation of proinflammatory mediators, (b) altering neutrophil or endothelial cell activation and (c) attenuating adhesion molecule expression on endothelium, neutrophils and myocytes. Monoclonal antibodies to adhesion molecules (P-selectin, L-selectin, CD11, CD18), complement fragments and receptors attenuate neutrophil-mediated injury (vascular injury, infarction), but clinical application may encounter limitations due to antigen-antibody reactions with the peptides. Humanized antibodies and non-peptide agents, such as oligosaccharide analogs to sialyl Lewis, may prove effective in this regard. Both nitric oxide and adenosine exhibit broad spectrum effects against neutrophil-mediated events and, therefore, can intervene at several critical points in the ischemic-reperfusion response, and may offer greater benefit than agents that interdict at a single point in the cascade. The understanding of the molecular processes regulating actions of neutrophils in ischemic-reperfusion injury may be applicable to other clinical situations, such as trauma, shock and organ or tissue (i.e. vascular conduits) transplantation.
A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? (2000)

Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins.
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrophoretic analysis of the major polypeptides of the human erythrocyte membraneG. Fairbanks, Theodore L. Steck, and D. F. H. WallachCite this: Biochemistry 1971, 10, 13, 2606–2617Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/bi00789a030https://doi.org/10.1021/bi00789a030research-articleACS PublicationsRequest reuse permissionsArticle Views4517Altmetric-Citations6745LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Experimental Study of Ti—Sn—Y System Phase Equilibria at 473 K (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Novel Method for Predicting Dexterous Individual Finger Movements by Imaging Muscle Activity Using a Wearable Ultrasonic System (2013)

Recently there have been major advances in the electro-mechanical design of upper extremity prosthetics. However, the development of control strategies for such prosthetics has lagged significantly behind. Conventional noninvasive myoelectric control strategies rely on the amplitude of electromyography (EMG) signals from flexor and extensor muscles in the forearm. Surface EMG has limited specificity for deep contiguous muscles because of cross talk and cannot reliably differentiate between individual digit and joint motions. We present a novel ultrasound imaging based control strategy for upper arm prosthetics that can overcome many of the limitations of myoelectric control. Real time ultrasound images of the forearm muscles were obtained using a wearable mechanically scanned single element ultrasound system, and analyzed to create maps of muscle activity based on changes in the ultrasound echogenicity of the muscle during contraction. Individual digit movements were associated with unique maps of activity. These maps were correlated with previously acquired training data to classify individual digit movements. Preliminary results using ten healthy volunteers demonstrated this approach could provide robust classification of individual finger movements with 98% accuracy (precision 96%-100% and recall 97%-100% for individual finger flexions). The change in ultrasound echogenicity was found to be proportional to the digit flexion speed (R(2)=0.9), and thus our proposed strategy provided a proportional signal that can be used for fine control. We anticipate that ultrasound imaging based control strategies could be a significant improvement over conventional myoelectric control of prosthetics.
Symmetry detection and dynamic variable ordering of decision diagrams (1994)

Knowing that some variables are symmetric in a function has numerous applications; in particular, it can help produce better variable orders for Binary Decision Diagrams (BDDs) and related data structures (e.g., Algebraic Decision Diagrams). It has been conjectured that there always exists an optimum order for a BBD wherein symmetric variables are contiguous. We propose a new algorithm for the detection of symmetries, based on dynamic reordering, and we study its interaction with the reordering algorithm itself. We show that combining sifting with an efficient symmetry check for contiguous variables results in the fastest symmetry detection algorithm reported to date and produces better variable orders for many BDDs. The overhead on the sifting algorithm is negligible.
A Dose-Escalation Study of Oxaliplatin and Vinorelbine in Patients with Advanced Solid Tumors (2002)

The results of this phase I study demonstrate that V and OX can be combined at clinically effective and relevant doses to be further evaluated in patients with breast and ovarian cancer.
Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (2020)

Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of COR-001, NCT02868229.
Pharmacokinetics of intravitreal carbenicillin, cefazolin, and gentamicin in rhesus monkeys. (1983)

Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus monkeys. Carbenicillin (1,000 micrograms), cefazolin (1,000 micrograms), or gentamicin (100 micrograms) was injected intravitreally. Vitreous and aqueous humors were aspirated at intervals up to 96 hours after injection. The half-life values in the vitreous humor were: carbenicillin 10 hours, cefazolin 7 hours, and gentamicin 33 hours. Concomitant intraperitoneal administration of probenecid prolonged the vitreal half-life of carbenicillin to 20 hours and of cefazolin to 30 hours. The estimated vitreous volumes in these monkeys were approximately 3.0-4.0 ml. These results are consistent with the hypothesis that, in primates as in rabbits, beta-lactam antibiotics are eliminated via the retinal route and the aminoglycoside via the anterior route. This supports the applicability of the rabbit model to the treatment of endophthalmitis in humans.
Online temporal calibration for camera–IMU systems: Theory and algorithms (2014)

When fusing visual and inertial measurements for motion estimation, each measurement’s sampling time must be precisely known. This requires knowledge of the time offset that inevitably exists between the two sensors’ data streams. The first contribution of this work is an online approach for estimating this time offset, by treating it as an additional state variable to be estimated along with all other variables of interest (inertial measurement unit (IMU) pose and velocity, biases, camera-to-IMU transformation, feature positions). We show that this approach can be employed in pose-tracking with mapped features, in simultaneous localization and mapping, and in visual–inertial odometry. The second main contribution of this paper is an analysis of the identifiability of the time offset between the visual and inertial sensors. We show that the offset is locally identifiable, except in a small number of degenerate motion cases, which we characterize in detail. These degenerate cases are either (i) cases known to cause loss of observability even when no time offset exists, or (ii) cases that are unlikely to occur in practice. Our simulation and experimental results validate these theoretical findings, and demonstrate that the proposed approach yields high-precision, consistent estimates, in scenarios involving either known or unknown features, with both constant and time-varying offsets.
Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer's disease (2015)

The hippocampal complex is affected early in Alzheimer's disease (AD). Increasingly, altered functional connectivity of the hippocampus is recognized as an important feature of preclinical AD. Carriers of the APOEɛ4 allele are at an increased risk for AD, which could lead to altered hippocampal connectivity even in healthy older adults. To test this hypothesis, we used a paired-associates memory task to examine differences in task-dependent functional connectivity of the anterior and posterior hippocampus in nondemented APOEɛ4 carriers (n = 34, 18F) and noncarriers (n = 46, 31F). We examined anterior and posterior portions of the hippocampus separately to test the theory that APOEɛ4-mediated differences would be more pronounced in the anterior region, which is affected earlier in the AD course. This study is the first to use a psychophysiological interaction approach to query the context-dependent connectivity of subregions of the hippocampus during a memory task in adults at increased genetic risk for AD. During encoding, APOEɛ4 carriers had lower functional connectivity change compared to baseline between the anterior hippocampus and right precuneus, anterior insula and cingulate cortex. During retrieval, bilateral supramarginal gyrus and right precuneus showed lower functional connectivity change with anterior hippocampus in carriers. Also during retrieval, carriers showed lower connectivity change in the posterior hippocampus with auditory cortex. In each case, APOEɛ4 carriers showed strong negative connectivity changes compared to noncarriers where positive connectivity change was measured. These differences may represent prodromal functional changes mediated in part by APOEɛ4 and are consistent with the anterior-to-posterior theory of AD progression in the hippocampus.
Neuropathological Alterations in Alzheimer Disease (2011)

The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. Despite their inherently cross-sectional nature, postmortem studies have enabled the staging of the progression of both amyloid and tangle pathologies, and, consequently, the development of diagnostic criteria that are now used worldwide. In addition, clinicopathological correlation studies have been crucial to generate hypotheses about the pathophysiology of the disease, by establishing that there is a continuum between "normal" aging and AD dementia, and that the amyloid plaque build-up occurs primarily before the onset of cognitive deficits, while neurofibrillary tangles, neuron loss, and particularly synaptic loss, parallel the progression of cognitive decline. Importantly, these cross-sectional neuropathological data have been largely validated by longitudinal in vivo studies using modern imaging biomarkers such as amyloid PET and volumetric MRI.
Parkinsonism with HIV infection (1998)

We describe six patients with parkinsonism and another 10 patients with parkinsonian features with human immunodeficiency virus (HIV) infection. In 50% of these patients, the symptoms were precipitated by neuroleptics. In the remaining patients, no obvious cause other than HIV infection was identified. Discontinuation of the neuroleptics produced complete recovery in one patient and partial or no response in others. Rapid progression of parkinsonism was noted in two patients, one of whom was treated with high-dose zidovudine (AZT) and benztropine. We conclude that patients with AIDS are at risk of developing an akinetic parkinsonism which may be precipitated by the use of neuroleptics, response to treatment is variable, and parkinsonism may be another primary HIV-induced syndrome.
Construction of Compactly Supported Non-Stationary Biorthogonal Wavelet System Based on Exponential B-splines (2006)

We construct new classes of non-stationary biorthogonal wavelet system, based on the exponential B-splines by the notion of asymtotically equivalent subdivison scheme. To illustrate our construction and results in this paper, we present some examples which reflect more successful application to signal analysis than classical biorthoganl wavelet generated by polynomial splines.
Measuring GSK3 Expression and Activity in Cells (2008)

Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action ofWnts. This protein kinase is ubiquitously expressed and has high inherent activity but is inhibited by activation of Wnt signalling or activation of growth factor receptor tyrosine kinases (e.g. insulin, nerve growth factor [NGF], platelet-derived growth factor [PDGF], etc.). The degree of inhibition of GSK3 in cells treated with such reagents is dependent on the cell type and the stimulus used. Therefore, the ability to accurately measure GSK3 activity in cells is an important aspect of GSK3 research. The activity of GSK3 is reduced by posttranslational modification (phosphorylation) and this can be measured by immunoblot with specific reagents (indirect), or by immunoprecipitation and assay (direct), as long as the modification is protected during these procedures. However, inhibition by phosphorylation is specific to cellular activation by growth factors and nutrients. Wnt inhibition of GSK3 does not involve phosphorylation of these residues on GSK3 and therefore it cannot be measured using this modification. Currently, the simplest way to assess Wnt inhibition of GSK3 is to monitor phosphorylation of specific GSK3 substrates in cells (e.g. beta-catenin). Alternatively, Wnt inhibition of GSK3 can be measured by partial purification of cellular GSK3 by ion exchange chromatography and assay of fractions or possibly by immunoprecipitation and assay. In this chapter, we demonstrate the use of the different approaches to measure GSK3 activity in SH-SY5Y cells, describe the best antibodies currently available, and discuss the potential drawbacks of each method.
Tunnel-Effect Displacement Sensor (1989)

Tunnel position sensor simple device measuring small displacements or accelerations. Used to make compact, sensitive accelerometers or strain gauges or to measure impacts of particles. Variation in distance between two electrodes measured via variation in tunneling current between them. Tunnel microsensors provide versatility for application as accelerometers, force sensors, strain sensors, particle detectors, and other devices for space applications.
Virtual hierarchies to support server consolidation (2007)

Server consolidation is becoming an increasingly popular technique to manage and utilize systems. This paper develops CMP memory systems for server consolidation where most sharing occurs within Virtual Machines (VMs). Our memory systems maximize shared memory accesses serviced within a VM, minimize interference among separate VMs, facilitate dynamic reassignment of VMs to processors and memory, and support content-based page sharing among VMs. We begin with a tiled architecture where each of 64 tiles contains a processor, private L1 caches, and an L2 bank. First, we reveal why single-level directory designs fail to meet workload consolidation goals. Second, we develop the paper's central idea of imposing a two-level virtual (or logical) coherence hierarchy on a physically flat CMP that harmonizes with VM assignment. Third, we show that the best of our two virtual hierarchy (VH) variants performs 12-58% better than the best alternative flat directory protocol when consolidating Apache, OLTP, and Zeus commel workloads on our simulated 64-core CMP.