gebhart/patrepeval huggingface dataset:
Clear weather meteorological effects on propagation at frequencies above 1 GHz (1981)

This paper reviews the various effects the clear atmosphere may have on the propagation of radio waves above 1 GHz. The role of the transfer processes at the lower boundary of the atmosphere in modifying the refractive index structure of air masses is reviewed, and some results of modification of refractive index and its structure constant by the lower boundary are shown. The formation of various classes of elevated layers is discussed and examples are shown of subsidence layer formation. The formation of refractive structures capping the convective boundary layer is discussed and examples of monsoonal refractive layers are shown. Examples of refractive index gradients and structure constant distributions in the neighborhood of frontal interfaces are also shown and discussed.
The Catalytic Nanodiode:  Gas Phase Catalytic Reaction Generated Electron Flow Using Nanoscale Platinum Titanium Oxide Schottky Diodes (2005)

Forty microampere current was generated on a platinum-titanium dioxide Schottky diode during the platinum catalyzed steady-state oxidation of carbon monoxide at 80 degrees C. For reaction events that produced four CO(2) molecules, three injected electrons were collected in a diode comprising a 5 nm thick platinum and a 150 nm titanium dioxide film. The electron injection flux depends on the thickness of the platinum and the titanium dioxide diode properties as well as the conditions of the catalytic reactions.
Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors (1991)

A fast and efficient method for medium scale purification of recombinant human tumor necrosis factor beta (rTNF-beta) from Escherichia coli cells is described. The purified rTNF-beta displayed biological activity similar to rTNF-alpha in a WEHI 164 cell cytotoxicity assay. The titration curve of rTNF-beta and elution profiles of rTNF-beta in gel filtration experiments were different from those of rTNF-alpha. However, light scattering and ultra-centrifugation studies showed that both cytokines have trimeric structures in solution at 0.5 mg/ml, with minor differences in the distribution of nontrimeric species. rTNF-beta bound to purified 55- and 75-kDa TNF receptors with high affinity. The binding of rTNF-beta to either receptor was analyzed on Scatchard plots and compared with that of rTNF-alpha.
Structural and kinetic aspects of chemical reactions in DNA duplexes. Information on DNA local structure obtained from chemical ligation data (1991)

Chemical ligation of oligonucleotides in double-stranded helices has been considered in its structural-kinetic aspect. A study was made of (i) two series of DNA duplexes with various arrangements of reacting groups in the ligation junction induced by mispairing or by alteration of furanose structure (the replacement of dT unit with rU, aU, IU, xU, dxT ones) and of (ii) eight synthetic water-soluble carbodiimides with different substituents at N1 and N3 atoms. We assumed that some information on the local structure of modified sites in the duplex can be obtained from kinetic parameters of oligonucleotide coupling reaction. The ratio of kinetic constants k 3 /(k 2 + k 3 ) for productive and nonproductive decomposition of the activated phosphomonoester derivative apparently reflects the reaction site structure: for a given duplex this parameter is virtually independent of the condensing agent composition. Based on the analysis of the chemical ligation kinetics a suggestion has been made about the conformation of some modified units in the double helix.
WEEKLY 24-HOUR INFUSION WITH HIGH-DOSE 5-FLUOROURACIL AND 6S-LEUCOVORIN AS A 2ND-LINE THERAPY IN ADVANCED COLORECTAL-CANCER RESISTANT TO A 5-FLUOROURACIL/6S-LEUCOVORIN BOLUS COMBINATION (1995)

Recently, experimental data suggested the possibility that resistance to 5FU may be overcome by administering the drug in a different schedule. To test this hypothesis we treated seventeen patients, who failed to respond to a common 5FU/leucovorin bolus regimen, with an intravenous infusion of 6S-leucovorin, at a dose of 250 mg/m(2), concurrently with 5FU at 2,600 mg/m(2) over a 24-hour period. Treatment was repeated every week. No patient achieved an objective response. Six patients showed stable disease and 11 progressed on therapy. The treatment with 5FU infusion, at least in this schedule, is not effective in patients with 5FU bolus resistant colon cancer.
Contribution of the Endothelium to the Glomerular Permselectivity Barrier in Health and Disease (2007)

Loss of GFR and proteinuria can result from glomerular endothelial cell injury.
Refined structure of human carbonic anhydrase II at 2.0 Å resolution (1988)

The structure of human erythrocytic carbonic anhydrase II has been refined by constrained and restrained structure-factor least-squares refinement at 2.0 A resolution. The conventional crystallographic R value is 17.3%. Of 167 solvent molecules associated with the protein, four are buried and stabilize secondary structure elements. The zinc ion is ligated to three histidyl residues and one water molecule in a nearly tetrahedral geometry. In addition to the zinc-bound water, seven more water molecules are identified in the active site. Assuming that Glu-106 is deprotonated at pH 8.5, some of the hydrogen bond donor-acceptor relations in the active site can be assigned and are described here in detail. The O gamma 1 atom of Thr-199 donates its proton to the O epsilon 1 atom of Glu-106 and can function as a hydrogen bond acceptor only in additional hydrogen bonds.
Simian T-Cell Lymphotropic Virus Type 1 from Mandrillus sphinx as a Simian Counterpart of Human T-Cell Lymphotropic Virus Type 1 Subtype D (1998)

A recent serological and molecular survey of a semifree-ranging colony of mandrills (Mandrillus sphinx) living in Gabon, central Africa, indicated that 6 of 102 animals, all males, were infected with simian T-cell lymphotropic virus type 1 (STLV-1). These animals naturally live in the same forest area as do human inhabitants (mostly Pygmies) who are infected by the recently described human T-cell lymphotropic virus type 1 (HTLV-1) subtype D. We therefore investigated whether these mandrills were infected with an STLV-1 related to HTLV-1 subtype D. Nucleotide and/or amino acid sequence analyses of complete or partial long terminal repeat (LTR), env, and rex regions showed that HTLV-1 subtype D-specific mutations were found in three of four STLV-1-infected mandrills, while the remaining monkey was infected by a different STLV-1 subtype. Phylogenetic studies conducted on the LTR as well as on the env gp21 region showed that these three new STLV-1 strains from mandrills fall in the same monophyletic clade, supported by high bootstrap values, as do the sequences of HTLV-1 subtype D. These data show, for the first time, the presence of the same subtype of primate T-cell lymphotropic virus type 1 in humans and wild-caught monkeys originating from the same geographical area. This strongly supports the hypothesis that mandrills are the natural reservoir of HTLV-1 subtype D, although the possibility that another monkey species living in the same area could be the original reservoir of both human and mandrill viruses cannot be excluded. Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently.
TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes (2005)

Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an invariant T cell antigen receptor (TCR) alpha chain, and unusual requirements for thymic selection. They rapidly produce many cytokines after stimulation and thus influence diverse immune responses and pathogenic processes. Because of intensive research effort, we have learned much about factors promoting the development and survival of NKT cells, regulation of their cytokine production, and the means by which they influence dendritic cells and other cell types. Despite this progress, knowledge of the natural antigen(s) they recognize and their physiologic role remain incomplete. The activation of NKT cells paradoxically can lead either to suppression or stimulation of immune responses, and we cannot predict which will occur. Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation.
Enhancement of Adenovirus-Mediated Gene Delivery by Use of an Oligopeptide with Dual Binding Specificity (1999)

The efficiency of human adenovirus serotype 5 (Ad5) transgene delivery was tested on several human and animal cell lines in vitro, by using a bimodular 35-mer oligopeptide carrying two peptide domains with different ligand specificities. One domain mimicked the fiber knob-binding region of the alpha2 domain of human MHC-1 molecules (MH20), and the other corresponded to the gastrin-releasing peptide (GRP). Two synthetic peptides with different configurations were analyzed in Ad-mediated gene transfer assays using Ad5Luc3 vector carrying the luciferase reporter gene. One peptide (GRP-MH20) had the GRP domain on the N-terminal side of MH20, while the other (MH20-GRP), the C-terminally amidified GRP, was on the C-terminal side of MH20. The GRP-MH20 peptide, but not MH20-GRP, was capable of enhancing luciferase gene delivery to Ad-susceptible cells in a GRP receptor-dependent manner. More importantly, GRP-MH20 could also confer susceptibility to Ad infection to normal or cancer cells that lack fiber receptors for the virus. Our data suggested that GRP receptors could function efficiently as alternative attachment receptors for Ad5, but that Ad5 bound to GRP receptors still depended, at least partially, on the penton base-mediated endocytotic pathway for subsequent cell entry. Gene delivery by a human adenovirus serotype 5 (Ad5) vector was assayed with a bimodular oligopeptide carrying two peptide domains of different binding specificities. One domain was a high-affinity peptide ligand of the Ad5 fiber knob (MH20), and the other corresponded to the gastrin-releasing peptide (GRP). The synthetic peptide GRP-MH20 was found to be capable of enhancing Ad-mediated gene transfer to Ad-susceptible cells in a GRP receptor-dependent manner. More importantly, GRP-MH20 could also confer susceptibility to Ad infection to normal or cancer cells that lack fiber receptors. Our data suggested that GRP receptors could function efficiently as alternative attachment receptors for Ad5, but virus bound to GRP receptors still depended partially on the penton base-mediated pathway for cell entry.
Down Syndrome: Neuropsychology and Animal Models (2000)

THE NEUROPSYCHOLOGY OF DOWN SYNDROME Down syndrome (DS) is the most prevalent genetic cause of mental retardation, affecting 1 in 700 live births (Stoll, Alembik, Dott, & Roth, 1990). It is caused by the presence of all or part of an extra copy of the 21st chromosome. Although this disorder has been recognized for more than a century (Down, 1866), the cognitive phenotype, with the exception of the language deficit and early onset dementia, is not well described. In addition, the mechanisms by which extra copies of normal (indeed, essential) genes produce the cognitive phenotype are not understood. This chapter reviews the known cognitive phenotype of DS and the contribution of existing animal models to the understanding of DS, providing an overview of the various types of animal models followed by a detailed analysis of the segmental trisomies.
A 200-MHz all-digital QAM modulator and demodulator in 1.2- μm CMOS for digital radio applications (1991)

A 200-MHz universal all-digital quadrature modulator and demodulator are presented for implementing the front-end signal processing functions for high-bit-rate digital radio applications. The modulator chip accepts a pair of 8-b in-phase and quadrature data streams and generates a band-limited IF digital output. The demodulator chip accepts a digitized IF input signal and generates a pair of filtered in-phase and quadrature baseband signals. The modulator and demodulator chips each incorporate matched 40-tap finite-impulse-response (FIR) square-root Nyquist filters and can accommodate symbol rates up to Mbd. The modulator chip can generate any arbitrary signal constellation within a rectangular grid of 256*256 points, thus resulting in a generic chip set suitable for a wide variety of high-bit-rate digital modem designs using various advanced multilevel modulation formats such as M-ary QAM. Both chips were fabricated in a 1.2- mu m CMOS process.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In search of design principles for tools and practices to support communication within a learning community (1998)

article Free Access Share on In search of design principles for tools and practices to support communication within a learning community Authors: Stephanie Houde View Profile , Rachel Bellamy View Profile , Laureen Leahy View Profile Authors Info & Claims ACM SIGCHI BulletinVolume 30Issue 2April 1998 pp 113–118https://doi.org/10.1145/279044.279171Online:01 April 1998Publication History 31citation217DownloadsMetricsTotal Citations31Total Downloads217Last 12 Months15Last 6 weeks11 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Synthese von (−)‐(R)‐Nephthenol und (−)‐(R)‐Cembren A (1988)

Synthesis of (−)‐( R )‐Nephthenol and (−)‐( R )‐Cembren A Starting for L ‐serine,(−)‐( R )‐nephthenol((−)‐ 2 ) and (−)‐( R )‐cembren A((−)‐ 3 ) were synthesized.
Reflectins: The Unusual Proteins of Squid Reflective Tissues (2004)

A family of unusual proteins is deposited in flat, structural platelets in reflective tissues of the squid Euprymna scolopes. These proteins, which we have named reflectins, are encoded by at least six genes in three subfamilies and have no reported homologs outside of squids. Reflectins possess five repeating domains, which are highly conserved among members of the family. The proteins have a very unusual composition, with four relatively rare residues (tyrosine, methionine, arginine, and tryptophan) comprising approximately 57% of a reflectin, and several common residues (alanine, isoleucine, leucine, and lysine) occurring in none of the family members. These protein-based reflectors in squids provide a marked example of nanofabrication in animal systems.
Methods for IPv4-IPv6 transition (2003)

The future Internet networks are expected to use IPv6 version rather than the IPv4 one. This is mainly due to the limitations of IPv4 in terms of addresses, routing and security QoS issues developed by the Internet community are also tailored for both versions and will be easily deployed in both sides. Since a huge amount of sub-networks are already installed for the v4 version, it is difficult to imagine ISPs starting deploying the v6 version without some assurance that old legacy networks will still be able to connect to the Internet. In this paper we present some mechanisms that have been proposed to ease this transition especially for v4 users that still want to communicate with their old applications. We present also an IPv6 tunneling mechanism that has some advantages over the other models. We show how one could use such a mechanism to transparently establish hybrid communications between two worlds in both ways and discuss some important issues like scalability and performance.
Paracrine regulation of osteoclast formation and activity: milestones in discovery. (2004)

The molecular and physiological mechanisms of control of osteoclast formation and activity have been explained with the discovery of three members of the Tumour Necrosis Factor superfamily. Receptor activator of NF-kappaB ligand (RANKL) is the type II membrane protein in cells of the osteoblastic lineage which interacts with its receptor, RANK, on hemopoietic precursors to promote osteoclast formation and maintain their viability and activity. The process is further regulated by the decoy receptor, osteoprotegerin (OPG), also produced by stromal/osteoblastic cells, and which binds to RANKL to prevent RANKL stimulation of osteoclast formation. These discoveries fulfilled predictions that came from more than 20 years of research in bone cell biology in predominantly rodent systems. The hypothesis that the osteoblast lineage directed osteoclast function introduced the concept of intercellular communication in bone. It needed new methods to be developed to test it, and there were many who contributed to this. With a number of identifiable milestones from the early 1980s on, a highly convincing case was made for the existence of what turned out to be RANKL and RANK. As it happened, OPG came first, and the background biological information was so instructive that it was obvious that OPG would lead to the final answer. By that stage the necessary methods were all in place, and in a short time all the key molecular regulators were identified. Ultimate proof of their physiological importance came from genetic experiments in mice.
Influence of Donor Microbiota on the Severity of Experimental Graft-versus-Host-Disease (2012)

The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell-mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.
Zwitterionic DNA (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTZwitterionic DNAHiromasa Hashimoto, Marek G. Nelson, and Christopher SwitzerCite this: J. Am. Chem. Soc. 1993, 115, 16, 7128–7134Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00069a009https://doi.org/10.1021/ja00069a009research-articleACS PublicationsRequest reuse permissionsArticle Views547Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Factors Affecting Foam Circulation in Oil Wells (1972)

This paper was prepared for presentation at the 47th Annual Fall Meeting of the Society of Petroleum Engineers held in San Antonio, Tex., Oct. 8–11, 1972. Permission to copy is restricted to an abstract of not more than 300 words. Illustrations may not be copied. The abstract should contain conspicuous acknowledgment of where and by who the paper is presented. Publication elsewhere after publication in the JOURNAL paper is presented. Publication elsewhere after publication in the JOURNAL OF PETROLEUM TECHNOLOGY or the SOCIETY OF PETROLEUM ENGINEERS JOURNAL is usually granted upon request to the Editor of the appropriate journal provided agreement to give proper credit is made. provided agreement to give proper credit is made. Discussion of this paper is invited. Three copies of any discussion should be sent to the Society of Petroleum Engineers office. Such discussion may be presented at the above meeting and, with the paper, may be considered for publication in one of the two SPE magazines. Abstract The utility of aqueous foams as circulating fluids in wells with low bottomhole pressure has been established. Although foams are simple to prepare, their behavior to changes in flow and well parameters is complex. The effects parameters is complex. The effects on foam flow of a number of these parameters were investigated by parameters were investigated by using a computerized mathematical model developed from newly reported research. Trends in job design factors such as injection pressure, bottomhole pressure, pressure, bottomhole pressure, circulation time and lifting ability are shown to be related to flow velocity and the liquid volume fraction of foam. A series of figures, some operating rules and a table summarizing directional trends of these design factors for a number of the more important flow and well parameters are presented. It is concluded that foam job design studies should be done when new lob objectives, well configurations or fields are encountered. Introduction The effectiveness and economic attractiveness of aqueous foam as a circulating fluid in well cleanout and drilling operations has been shown. Foam is increasingly important for a wide variety of oil field work where its low density and relatively high solids-lifting capability are needed. Foam has been successfully used in conventional and thru-tubing operations both onshore and offshore, in hard rock and soft sand provinces, and in permafrost areas. A vast amount of permafrost areas. A vast amount of experience with this unusual fluid is now commercially available from a number of service companies who have completed approximately two thousand foam circulation jobs. Prediction of optimum gas and liquid rates, pressures, circulation time or solids-lifting ability is often difficult because of the complexity of foam circulation in wells.