gebhart/patrepeval huggingface dataset:
Iκκ Mediates NF-κB Activation in Human Immunodeficiency Virus-Infected Cells (1999)

Human monocytes and macrophages are persistent reservoirs of human immunodeficiency virus (HIV) type-1. Persistent HIV infection of these cells results in increased levels of NF-kappaB in the nucleus secondary to increased IkappaBalpha, IkappaBbeta, and IkappaBepsilon degradation, a mechanism postulated to regulate viral persistence. To characterize the molecular mechanisms regulating HIV-mediated degradation of IkappaB, we have sought to identify the regulatory domains of IkappaBalpha targeted by HIV infection. Using monocytic cells stably expressing different transdominant molecules of IkappaBalpha, we determined that persistent HIV infection of these cells targets the NH2 but not the COOH terminus of IkappaBalpha. Further analysis demonstrated that phosphorylation at S32 and S36 is necessary for HIV-dependent IkappaBalpha degradation and NF-kappaB activation. Of the putative N-terminal IkappaBalpha kinases, we demonstrated that the Ikappakappa complex, but not p90(rsk), is activated by HIV infection and mediates HIV-dependent NF-kappaB activation. Analysis of viral replication in cells that constitutively express IkappaBalpha negative transdominant molecules demonstrated a lack of correlation between virus-induced NF-kappaB (p65/p50) nuclear translocation and degree of viral persistence in human monocytes.
The ALCELL process--a proven alternative to kraft pulping (1991)

Presentation du procede Alcell, qui utilise l'ethanol aqueux comme liqueur de cuisson. On obtient des pâtes blanchies de haute qualite a partir de feuillus et de plantes annuelles. Il apparait que de telles installations peuvent etre economiquement interessantes pour une production d'environ 300t/j.
Session Initiation Protocol for Telephones (SIP-T): Context and Architectures (2002)

The popularity of gateways that interwork between the PSTN (Public Switched Telephone Network) and SIP networks has motivated the publication of a set of common practices that can assure consistent behavior across implementations. This document taxonomizes the uses of PSTN-SIP gateways, provides uses cases, and identifies mechanisms necessary for interworking. The mechanisms detail how SIP provides for both 'encapsulation' (bridging the PSTN signaling across a SIP network) and 'translation' (gatewaying).
Statistics for behavioral sciences (1985)

By far the best-selling introduction to statistics for students in the behavioral and social sciences, this text continues to offer straightforward instruction, accuracy, built-in learning aids, and real-world examples. The goal of STATISTICS FOR THE BEHAVIORAL SCIENCES, 8th Edition is to not only teach the methods of statistics, but also to convey the basic principles of objectivity and logic that are essential for science and valuable in everyday life. Authors Frederick Gravetter and Larry Wallnau help students understand statistical procedures through a conceptual context that explains why the procedures were developed and when they should be used. Students have numerous opportunities to practice statistical techniques through Learning Checks, examples, step-by-step Demonstrations, and problems. A strong ancillary package includes PowerLecture, which contains lecture slides, JoinIn Student Response System content, and a computerized test bank; Enhanced WebAssign, a complete and easy-to-use homework management system; WebTutor; an Instructor's Manual/TestBank, plus other online and print resources.
The evolution of vertebrate Toll-like receptors (2005)

The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular patterns has maintained a largely unchanging TLR recognition in all vertebrates. There are six major families of vertebrate TLRs. This repertoire is distinct from that of invertebrates. TLRs within a family recognize a general class of pathogen-associated molecular patterns. Most vertebrates have exactly one gene ortholog for each TLR family. The family including TLR1 has more species-specific adaptations than other families. A major family including TLR11 is represented in humans only by a pseudogene. Coincidental evolution plays a minor role in TLR evolution. The sequencing phase of this study produced finished genomic sequences for the 12 Takifugu rubripes TLRs. In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt.
Modeling the Spinal Cord Neural Circuitry Controlling Cat Hindlimb Movement During Locomotion (2002)

The spinal cord neural circuitry was modeled as a network of interacting neuronal modules (NMs). Each NM includes a network of alpha-motoneurons, Renshaw, Ia and Ib interneurons, and interneurons associated with the central pattern generator (CPG). The CPG was integrated with reflex circuits. Each of two three-joint hindlimbs was actuated by 9 one- and two-joint flexor and extensor muscles. The objective was to find the network architecture within and between the NMs that provides stable locomotion with different gaits, realistic patterns of muscle activation, and limb movement kinematics. The results of modeling are discussed in the context of experimental data on cat locomotion.
Tools for DNS debugging (1994)

Although widely used (and most of the times unnoticed), DNS (Domain Name System) is too much overlooked, in the sense that people, especially administrators, tend to ignore possible anomalies as long as applications that need name-to-address mapping continue to work. This document presents some tools available for domain administrators to detect and correct those anomalies.
Carbon dioxide activation and catalytic lactone synthesis by telomerization of butadiene and carbon dioxide (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon dioxide activation and catalytic lactone synthesis by telomerization of butadiene and carbon dioxidePierre. Braunstein, Dominique. Matt, and Dominique. NobelCite this: J. Am. Chem. Soc. 1988, 110, 10, 3207–3212Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ja00218a033https://doi.org/10.1021/ja00218a033research-articleACS PublicationsRequest reuse permissionsArticle Views1341Altmetric-Citations132LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Relationship Between Venture Capitalists and Managers in New Firms: Determinants of Contractual Covenants (1994)

Two types of opportunism, managerial and competitive, are described. Contractual covenants that control these types of opportunism are used when they are likely to occur, i.e., when there are obstacles to monitoring management behavior and when returns to starting new firms are large. These ideas are subjected to empirical test. The relationship between managers in new firms and venture capitalists is receiving increased attention in the literature (Norton and Tenenbaum 1990; Sahlman, 1988). The determinants and implications of several attributes of these relationships have been examined, including the percentage of a new firm's equity held by venture capitalists, the number of seats on the board controlled by venture capitalists, and the post‐funding activities of venture capitalists (e.g., helping the new firm raise additional capital, contacting customers, replacing management) (Barney, Busenitz, Fiet, and Moesel, 1989). While our understanding of the relationship between managers in new firms and venture capitalists is growing, one particularly important component of that relationship has yet to receive significant attention in the literature: the details of the formal contractual arrangement between managers in a new firm and venture capitalists. Often called the “terms and conditions” of the relationship between managers and venture capitalists, these contractual details specify the rights and obligations of both managers and venture capitalists throughout their entire relationship in a series of covenants (Fiet, 1991). Among other items, contractual covenants can specify limits on capital expenditures, limits on managerial salaries, limitations on raising additional outside capital, technology non‐disclosure agreements, and conditions for forcing a change in managing and liquidating the deal. The purpose of this paper is to understand the determinants of the formal contractual arrangements between managers in new firms and venture capitalists.
Resonant Electron Scattering by Defects in Single-Walled Carbon Nanotubes (2001)

We report the characterization of defects in individual metallic single-walled carbon nanotubes by transport measurements and scanned gate microscopy. A sizable fraction of metallic nanotubes grown by chemical vapor deposition exhibits strongly gate voltage-dependent resistance at room temperature. Scanned gate measurements reveal that this behavior originates from resonant electron scattering by defects in the nanotube as the Fermi level is varied by the gate voltage. The reflection coefficient at the peak of a scattering resonance was determined to be about 0.5 at room temperature. An intratube quantum dot device formed by two defects is demonstrated by low-temperature transport measurements.
Effects of floating body on double polysilicon partially depleted SOI nonvolatile memory cell (2003)

The floating-body effect of nonvolatile memory cells fabricated using partially depleted silicon-on-insulator (SOI) technology has been investigated using two-dimensional numerical device simulation. Compared with similar bulk devices, the floating-body effect of partially depleted SOI MOSFETs introduces instability in the value of the drain current during sensing and extra hot-electron gate current in programming. The effects of the drain-current instability on the error margins in read operation are studied. The floating-body effect is found to be heavily dependent on biasing condition.
Application and Mechanism of Inhalation Profile Improvement of DPI Formulations by Mechanofusion with Magnesium Stearate (2008)

In our previous paper, we reported the inhalation properties of dry powder inhaler (DPI) formulations containing Compound A and mechanofusion-processed lactose carriers. The mechanofusion process with magnesium stearate (Mg-St) on the lactose carrier enhanced the fine particle fraction (FPF) value of the Andersen cascade impactor (ACI) study. The increase of FPF seemed to be associated with the increase of the dispersibility of drug particles. The objectives of this study were (1) to evaluate the applicability of lactose carrier mechanofusion-processed with Mg-St and (2) to examine the mechanism of FPF alteration by the mechanofusion process applied on the lactose carrier with or without additive. The inhalation profiles of DPI formulations containing four different pharmaceutical compounds were evaluated with an ACI. The dispersibility of the formulations was observed by particle size distribution measurement in the air stream and the adhesive force was measured bydirect separation method. It was found that higher FPF was obtained with lactose mechanofusion-processed with Mg-St as compared to control lactose carriers for all four compounds. This suggested that mechanofusion process with Mg-St is widely applicable in DPI formulations. The homogenization of surface adhesiveness was attributed to the increased FPF of the DPI including lactose mechanofusion-processed with Mg-St, as suggested by the combination of several physicochemical characteristics. Combination of different characterization methods would be of help to clarify the whole mechanism which defines the inhalation properties of DPI formulations.
A study of OFDM system applying frequency diversity (2002)

An OFDM system is widely known as a modulation scheme, which can reduce the effect of frequency selective fading. However, under a large frequency selective fading environment, it is difficult to demodulate correctly even with appropriate equalization. In this paper, an OFDM system applying a frequency diversity scheme is proposed. In this system, the same symbols are transmitted on several sets of carriers, and at the receiver end, these symbols are combined so as to maximize the signal to noise ratio. As the experimental result, it is shown that as the fading level becomes larger, the proposed system provides a larger gain in the bit error rate characteristics than the conventional system.
The Glu(B13) carboxylates of the insulin hexamer form a cage for cadmium and calcium ions (1985)

Substitution of Cd2+ for Zn2+ yields a hexameric insulin species containing 3 mol of metal ion per hexamer. The Cd2+ binding loci consist of the two His(B10) sites and a new site involving the Glu(B13) residues located at the center of the hexamer [Sudmeier, J. L., Bell, S. J., Storm, M. C., & Dunn, M. F. (1981) Science (Washington, D.C.) 212, 560-562]. Substitution of Co2+ or Co3+ for Zn2+ gives hexamers containing 2 mol of metal per hexamer. Insulin solutions to which both Cd2+ and Co2+ have been added in a ratio of 6:2:1 [In]:[Co2+]:[Cd2+] followed by oxidation to the exchange-inert Co3+ state yield stable hybrid species containing both Co3+ and Cd2+ with a composition of (In)6(Co3+)2Cd2+. The kinetics of the reaction of 2,2',2"-terpyridine (terpy) with the exchange-labile (In)6(Cd2+)2 and (In)6(Co2+)2 derivatives are biphasic and involve the rapid formation of an intermediate with coordination of one terpy molecule to each protein-bound metal ion; then, in a rate-limiting step the terpy-coordinated metal ion dissociates from the protein, and a second molecule of terpy binds to the metal ion to form a bis complex. Reaction of the exchange-inert Co3+ ions of (In)6(Co3+)2 with terpy is a slow apparent first-order process (t1/2 = 13.1 h). In contrast to the kinetic behavior of (In)6(Co2+)2 and (In)6(Cd2+)2, the Cd2+ ions bound to the hybrid (In)6(Co3+)2Cd2+ react quite slowly with terpy (t1/2 = 1 h at pH 8.0).(ABSTRACT TRUNCATED AT 250 WORDS)
Primary structure and expression of a gamete lytic enzyme in Chlamydomonas reinhardtii: similarity of functional domains to matrix metalloproteases. (1992)

A gamete lytic enzyme (GLE) of Chlamydomonas reinhardtii is a zinc metalloprotease and mediates digestion of the cell walls of the two mating-type gametes during mating as a necessary prelude to cell fusion. The nucleotide sequence analysis of a cDNA revealed that GLE is synthesized in a preproenzyme form, a 638-amino acid polypeptide (Mr, 69,824) with a 28-amino acid signal peptide, a 155-amino acid propolypeptide, and a 455-amino acid mature polypeptide (Mr, 49,633). A potential site for autocatalytic activation was contained within the propolypeptide and a zinc binding site found within the mature polypeptide; both sites were highly homologous to those in mammalian collagenase. A putative calcium binding site was present in the near C-terminal region of the mature GLE. Both propolypeptide and mature polypeptide had potential sites for asparagine-linked glycosylation, and the Arg-(Pro)3 and Arg-(Pro)2 motifs, which are known to exist in hydroxyproline-rich glycoproteins of the Chlamydomonas cell wall. Northern blot analysis revealed that steady-state levels of the 2.4-kilobase GLE mRNA increased during growth and mitotic cell division in the vegetative cell cycle and also increased markedly during gametogenesis under nitrogen-starved conditions.
Instrument Engineers' Handbook, Volume One (2003)

Unsurpassed in its coverage, usability, and authority since its first publication in 1969, the three-volume Instrument Engineers' Handbook continues to be the premier reference for instrument engineers around the world. It helps users select and implement hundreds of measurement and control instruments and analytical devices and design the most cos
3D beamforming trials with an active antenna array (2012)

Beamforming techniques for mobile wireless communication systems like LTE using multiple antenna arrays for transmission and reception to increase the signal-to-noise-and-interference ratio (SINR) are state of the art. The increased SINR is not only due to a larger gain in the direction of the desired user, but also due to a better control of the spatial distribution of interference in the cell. To further enhance the system performance not only the horizontal, but also the vertical dimension can be exploited for beam pattern adaptation, thus giving an additional degree of freedom for interference avoidance among adjacent cells. This horizontal and vertical beam pattern adaptation is also referred to as 3D beamforming in the following. This paper describes investigations of the potential of 3D beamforming with lab and field trial setups and provides initial performance results.
Optical Absorption of the Transition Elements in Vitreous Silica (1974)

The optical absorption of 3d transition elements in fused silica was studied. A series of high‐quality silica glasses doped with 0.01 to 0.1 wt% of each transition element (V through Cu) was prepared by a vapor hydrolysis technique. Their optical spectra were measured, and their practical absorptivities were calculated between 200 and 2000 nm. In the proposed waveguide use range (∼ 850 nm), V and Cr appear to absorb most (a pract = 2.6 and 1.2 dB/km ppbw −1 (metal), respectively) and Cu the least (a pract ≃0). Comparisons are made with data for conventional glasses.
Optimal local shape description for rotationally non-symmetric optical surface design and analysis (2008)

A local optical surface representation as a sum of basis functions is proposed and implemented. Specifically, we investigate the use of linear combination of Gaussians. The proposed approach is a local descriptor of shape and we show how such surfaces are optimized to represent rotationally non-symmetric surfaces as well as rotationally symmetric surfaces. As an optical design example, a single surface off-axis mirror with multiple fields is optimized, analyzed, and compared to existing shape descriptors. For the specific case of the single surface off-axis magnifier with a 3 mm pupil, >15 mm eye relief, 24 degree diagonal full field of view, we found the linear combination of Gaussians surface to yield an 18.5% gain in the average MTF across 17 field points compared to a Zernike polynomial up to and including 10th order. The sum of local basis representation is not limited to circular apertures.
L-Glutamine Supplementation Improves Nelfinavir-Associated Diarrhea in HIV-Infected Individuals (2003)

In this population of HIV-positive participants, L-glutamine 30 g/day significantly (p <.01) reduced the severity of nelfinavir-associated diarrhea and produced improved quality of life compared with placebo.
Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1 (2007)

Apoptosis signal-regulating kinase (ASK) 1 is a mitogen-activated protein kinase kinase kinase (MAP3K) in the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase pathways that play multiple important roles in cytokine and stress responses. Here we show that ASK2, a highly related serine/threonine kinase to ASK1, also functions as a MAP3K only in a heteromeric complex with ASK1. We found that endogenous ASK2 was constitutively degraded in ASK1-deficient cells, suggesting that ASK1 is required for the stability of ASK2. ASK2 in a heteromeric complex with a kinase-negative mutant of ASK1 (ASK1-KN) effectively activated MAP2K and was more competent to respond to oxidative stress than ASK2 alone. Knockdown of ASK2 revealed that ASK2 was required for oxidative stress-induced JNK activation. These results suggest that ASK2 forms a functional MAP3K complex with ASK1, in which ASK1 supports the stability and the active configuration of ASK2. Moreover, ASK2 was found to activate ASK1 by direct phosphorylation, suggesting that ASK1 and ASK2 in a heteromeric complex facilitate their activities to each other by distinct mechanisms. Such a formation of functional heteromeric complex between different MAP3Ks may be advantageous for cells to cope with a wide variety of stimuli by fine regulation of cellular responses.
The Retinal Nerve Fiber Layer Thickness in Ocular Hypertensive, Normal, and Glaucomatous Eyes With Optical Coherence Tomography (2000)

These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes.
Monoclonal antibody–drug conjugates (2005)

This review covers cytotoxic antibody–drug conjugates for use in oncology. The focus is on drug conjugates of current interest, such as those of the taxanes, maytansines, CC-1065 and the duocarmycins, the calicheamicins and other enediynes, and the auristatins. A few classes of drug conjugates from earlier work are also mentioned, such as those of the antifolates, vinca alkaloids, and the anthracyclines. Also covered are some more recent linker systems that are useful for making antibody–drug conjugates. This review does not cover conjugates of plant toxins, other bioactive proteins, enzymes (i.e., antibody-directed enzyme prodrug therapy [ADEPT]), radioisotopes (photodynamic therapy), or conjugates made with secondary carriers for the cytotoxic agent, such as liposomes or polymers.
Regulation of ribonuclease III processing by double-helical sequence antideterminants (1997)

The double helix is a ubiquitous feature of RNA molecules and provides a target for nucleases involved in RNA maturation and decay. Escherichia coli ribonuclease III participates in maturation and decay pathways by site-specifically cleaving double-helical structures in cellular and viral RNAs. The site of cleavage can determine RNA functional activity and half-life and is specified in part by local tertiary structure elements such as internal loops. The involvement of base pair sequence in determining cleavage sites is unclear, because RNase III can efficiently degrade polymeric double-stranded RNAs of low sequence complexity. An alignment of RNase III substrates revealed an exclusion of specific Watson-Crick bp sequences at defined positions relative to the cleavage site. Inclusion of these "disfavored" sequences in a model substrate strongly inhibited cleavage in vitro by interfering with RNase III binding. Substrate cleavage also was inhibited by a 3-bp sequence from the selenocysteine-accepting tRNASec, which acts as an antideterminant of EF-Tu binding to tRNASec. The inhibitory bp sequences, together with local tertiary structure, can confer site specificity to cleavage of cellular and viral substrates without constraining the degradative action of RNase III on polymeric double-stranded RNA. Base pair antideterminants also may protect double-helical elements in other RNA molecules with essential functions.