gebhart/patrepeval huggingface dataset:
Pulmonary brucellosis. (1989)

Pulmonary abnormalities in brucellosis are rare. We report on nine cases (five adults and four children) with pulmonary brucellosis. All presented with fever, cough and mucopurulent sputum, and most had abnormal signs in the chest. Radiography of the chest showed pneumonic patches or consolidation in five patients, pleural effusion in three, granuloma of the lung in one and a picture of interstitial pneumonitis in one. All the patients had a brucella agglutination titre of 1:320 or more, and an elevated titre in the brucella-specific enzyme linked immunosorbent assay of IgM, IgG and IgA. Blood cultures grew Brucella melitensis in six patients while the pleural fluid aspirate grew the same organism in two of three patients. Treatment with oral oxytetracycline, doxycycline, rifampicin, trimethoprim-sulfamethoxazole alone, in combination with each other or together with intramuscular streptomycin was successful in all patients. All our patients recovered and none relapsed.
Nucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediates (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediatesRobert L. Letsinger and Kelvin K. OgilvieCite this: J. Am. Chem. Soc. 1969, 91, 12, 3350–3355Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/ja01040a042https://doi.org/10.1021/ja01040a042research-articleACS PublicationsRequest reuse permissionsArticle Views808Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Implementation of damped-oscillation crane control for existing ac induction motor-driven cranes (1993)

The Oak Ridge National Laboratory (ORNL) has implemented damped-oscillation crane control on one of its existing ac induction motor-driven facility overhead cranes. The purpose of this engineering grade test has been to determine feasibility, determine control and interfacing specifications, and establish the capability of newly available ac motor-control hardware. A flux vector inverter drive is used in the initial demonstration to investigate acceptability for swing-free crane control. Motor performance and restrictions are also examined. Control hardware design is based upon the Environmental Restoration and Waste Management (ER WM) Robotics Technology Development Program (RTDP) standards. This includes the use of the VME bus and Motorola 680X0-based CPU boards for the hardware and UNIX and VxWorks for the software. However, smaller, cheaper, and more simple embedded controller design constraints are also considered in order to make the technology more attractive for general industrial use. Theoretical background, specific implementation, and recommendations are presented in this paper.
Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs (2015)

Treatment of chronic HIV-1 infection with potent broadly neutralizing HIV-1 MAbs has been shown to significantly reduce plasma viremia. However, the antiviral effect of MAb treatment during acute HIV-1 infection is unknown. Here, we demonstrate that MAbs targeting the HIV-1 envelope glycoprotein both suppress acute SHIV plasma viremia and limit CD4 T cell-associated viral DNA. These findings provide support for clinical trials of MAbs as adjunctive therapy with antiretroviral therapy during acute HIV-1 infection.
Service-Driven Web Manufacturing: A Roadmap from Methodology to Applications. (2006)

This invited talk deals with studying a service-driven web manufacturing methodology and exploring its potential applications in industry. In the aspect of methodology, basic equipment e-service model, manufacturing executive system configuration, and system running in the context of real-time information scheduling, sharing and tracking mechanism are three key issues that should be solved in advance. On the basis of our bottom-up research strategy, first of all, an e-service fundamental model attached to any a CNC machine tool is put forward. It is actually a server front-end of the machine tool and is able to provide online service functions including machining data sampling and handling, process quality control, machining operations visualization, collaboration, etc, through three modes, that is, access mode, subscription mode and broadcast mode. In terms of connecting all server front-ends with each other, secondly, we establish a web-based manufacturing executive system referring to decomposing the manufacturing tasks and allocating necessary manufacturing resources by means of using both BOM and Gantt charts. Furthermore, this web-based manufacturing executive system in a “Browser/Server/Web Database” three-tire architecture can run under the control of real-time information scheduling, sharing and tracking mechanism based on a time-dependent instantiated template net (TIT-net). As methodology verification, we use an industrial case to demonstrate the methodology mentioned above. The further potential applications in industry are also discussed in detail in this invited talk.
Fontolizumab, a humanised anti-interferon antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease (2005)

Treating active CD with fontolizumab was well tolerated and resulted in increased rates of clinical response and remission compared with placebo.
Chromosome alterations in 21 non‐small cell lung carcinomas (1990)

Cytogenetic analysis was performed on 16 primary tumors, 2 effusions, and 3 cell lines from 21 patients with non-small cell lung cancer (NSCLC). In 20 patients specimens were obtained prior to initiating cytotoxic therapy. Extensive clonal chromosome alterations were found in all cases. The most frequent numerical changes were polysomy 7 and polysomy 20 (each seen in 12 specimens). In addition, tumor cells from another six cases exhibited partial trisomy 7, with the shortest region of overlap (SRO) at 7p11-p13. Rearrangements of chromosomes 1, 3, 6, 8, 11, 15, 17, and 19 were each observed in nine or more tumors. Breakpoints were clustered at several chromosomal sites, including 1p13, 3p13, 15p11-q11, 17p11, and 19q13. Recurrent loss involving 1p, 3p, 6q, 11p, 15p, 17p, and 19q were each seen in at least eight cases. The SRO of 3p losses was at band 3p21. Double minute chromosomes were found in three tumors. Overall, our findings indicate that even though karyotypes in newly diagnosed NSCLC are very complex, recurrent cytogenetic changes can be identified. The high incidence of loss of 17p (14 of 21 specimens) appears to be compatible with reports implicating the TP53 gene (at band 17p13) as a frequent site for genetic alteration in lung cancer. Moreover, the recurrence of loss of 3p (12 cases) and 11p (10 cases) is also consistent with recent molecular evidence. The existence of other "hot spots" for cytogenetic change, particularly those involving specific regions on chromosomes 7, 15, and 19, warrants further molecular investigation of these sites in NSCLC.
Serum Amyloid A is a Better Predictor of Clinical Outcomes than C-Reactive Protein in Non-ST-Segment Elevation Acute Coronary Syndromes (2007)

Regardless of the level of CRP, elevated SAA is associated with adverse 30-day outcomes in patients with NSTE-ACS, so SAA is a better predictor of clinical outcome than CRP in these patients.
DNA Sequences Essential for Replication of the B Genome Component of Tomato Golden Mosaic Virus (1989)

Gwen N. Revington, Garry Sunter, David M. Bisaro, DNA Sequences Essential for Replication of the B Genome Component of Tomato Golden Mosaic Virus, The Plant Cell, Vol. 1, No. 10 (Oct., 1989), pp. 985-992
Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study (1989)

Although numerous studies have confirmed the presence of larger cerebral ventricles in schizophrenia, the locus of tissue loss remains elusive. By analyzing magnetic resonance scans with computerized image analysis, the authors determined gray and white matter volumes in the temporal lobes and prefrontal regions of 17 patients with schizophrenia and 17 age- and sex-matched normal subjects. The volume of temporal lobe gray matter was 20% smaller in the patients than in the control subjects. The lateral ventricular volume was 67% larger in the patients and, when normalized for brain size, correlated inversely with the volume of temporal lobe gray matter.
Peer-to-peer internet telephony using SIP (2005)

P2P systems inherently have high scalability, robustness and fault tolerance because there is no centralized server and the network self-organizes itself. This is achieved at the cost of higher latency for locating the resources of interest in the P2P overlay network. Internet telephony can be viewed as an application of P2P architecture where the participants form a self-organizing P2P overlay network to locate and communicate with other participants. We propose a pure P2P architecture for the Session Initiation Protocol (SIP)-based IP telephony systems. Our P2P-SIP architecture supports basic user registration and call setup as well as advanced services such as offline message delivery, voice/video mails and multi-party conferencing. We also provide an overview of practical challenges for P2P-SIP such as firewall, Network Address Translator (NAT) traversal and security.
Mesenteric B cells centrally inhibit CD4+T cell colitis through interaction with regulatory T cell subsets (2005)

Inflammatory bowel disease reflects an aberrant mucosal CD4+ T cell response to commensal enteric bacteria. In addition to regulatory T cell subsets, recent studies have revealed a protective role of B cells in murine CD4+ T cell colitis, but the relationship of their action to T cell immunoregulation is unknown. Here we report that mesenteric lymph node (MLN) B cells protect mice from colitis induced by Galphai2-/- CD4+ T cells. Protection required the transfer of both B cells and CD8alpha+ T cells; neither cell type alone was sufficient to inhibit CD4+ T cell-mediated colitis. Similar results were also observed in colitis induced by CD4+CD45RBhi T cells. Immunoregulation was associated with localization of B cells and expansion of CD4-CD8- CD3+NK1.1+ T cells in the secondary lymphoid compartment, as well as expansion of CD4+CD8alpha+ T cells in the intestinal intraepithelial compartment. MLN B cells from Galphai2-/- mice were deficient in a phenotypic subset and failed to provide cotransfer colitis protection. These findings indicate that protective action of B cells is a selective trait of MLN B cells acquired through a Galphai2-dependent developmental process and link B cells with the formation of regulatory T cells associated with mucosal immune homeostasis.
In Vitro Production of a TRH‐Homologous Peptide and His‐Pro Diketopiperazine by Human Semen (1985)

Fresh human semen, diluted 1:1 v/v with 0.15 M NaCl- 0.05 M phosphate, pH 7.5, undergoes a 3-fold increase in total thyrotropin-releasing hormone (TRH) immunoreactivity on incubation at 4 C for 8 to 16 hours. To identify the mechanism for this increase, pooled human semen was incubated at 4, 37, and 60 C, and the change in composition of the immunoreactive TRH peptides was quantitated by high pressure liquid chromatography and radioimmunoassay of TRH. His-Pro diketopiperazine, a biologically active metabolite of TRH consisting of a cyclic dipeptide of histidine and proline, also was measured by specific RIA. The concentration of TRH (pGlu-His-Pro-NH2) dropped precipitously within the first hour after dilution and incubation at all temperatures studied. A hydrophobic TRH-homologous peptide with the amino acid composition (Glu,X,Y,Pro), where X and Y are neutral, nonaromatic amino acids, increased 8-fold during 16 hours of incubation at 4 C. This TRH-homologous peptide is not derived from TRH because it lacks the histidine is not derived from TRH because it lacks the histidine residue. A 3- to 23-fold increase in His-Pro diketopiperazine levels occurred after 4 hours at 37 C. This was not due primarily to enzymatic removal of the pyroglutamyl residue from TRH by pyroglutamate aminopeptidase, since about 1 hour after ejaculation the initial His-Pro diketopiperazine levels were 9.7 +/- 5.1 micrograms/ml, or approximately 1000-fold greater than the corresponding levels of seminal TRH. Because cycloheximide, which blocks ribosomal protein biosynthesis, did not inhibit in vitro production of the TRH-homologous peptide and the His-Pro cyclic dipeptide, these peptides, like TRH, most likely arise from post-translational cleavage and processing from pre-existing macromolecular precursor proteins.
Free Radical Additions Involving Fluorine Compounds. IV. The Addition of Dibromodifluoromethane to Some Fluoroölefins1 (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree Radical Additions Involving Fluorine Compounds. IV. The Addition of Dibromodifluoromethane to Some Fluoroölefins1Paul Tarrant, Alan M. Lovelace, and Marvin R. LilyquistCite this: J. Am. Chem. Soc. 1955, 77, 10, 2783–2787Publication Date (Print):May 1, 1955Publication History Published online1 May 2002Published inissue 1 May 1955https://doi.org/10.1021/ja01615a033RIGHTS & PERMISSIONSArticle Views375Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (670 KB) Get e-Alerts Get e-Alerts
Interspecies biofilms ofPseudomonas aeruginosaandBurkholderia cepacia (2001)

The leading cause of morbidity and mortality in cystic fibrosis (CF) continues to be lung infections with Pseudomonas aeruginosa biofilms. Co-colonization of the lungs with P aeruginosa and Burkholderia cepacia can result in more severe pulmonary disease than P. aeruginosa alone. The interactions between P. aeruginosa biofilms and B. cepacia are not yet understood; one possible association being that mixed species biofilm formation may be part of the interspecies relationship. Using the Calgary Biofilm Device (CBD), members of all genomovars of the B. cepacia complex were shown to form biofilms, including those isolated from CF lungs. Mixed species biofilm formation between CF isolates of P. aeruginosa and B. cepacia was readily achieved using the CBD. Oxidation-fermentation lactose agar was adapted as a differential agar to monitor mixed biofilm composition. Scanning electron micrographs of the biofilms demonstrated that both species readily integrated in close association in the biofilm structure. Pseudomonas aeruginosa laboratory strain PAO1, however, inhibited mixed biofilm formation of both CF isolates and environmental strains of the B. cepacia complex. Characterization of the soluble inhibitor suggested pyocyanin as the active compound.
Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes (1998)

A growing number of human tumor antigens have been described that can be recognized by cytotoxic T lymphocytes (CTLs) in a major histocompatibility complex (MHC) class I-restricted fashion. Serological screening of cDNA expression libraries, SEREX, has recently been shown to provide another route for defining immunogenic human tumor antigens. The detection of antibody responses against known CTL-defined tumor antigens, e.g., MAGE-1 and tyrosinase, raised the question whether antibody and CTL responses against a defined tumor antigen can occur simultaneously in a single patient. In this paper, we report on a melanoma patient with a high-titer antibody response against the "cancer-testis" antigen NY-ESO-1. Concurrently, a strong MHC class I-restricted CTL reactivity against the autologous NY-ESO-1-positive tumor cell line was found. A stable CTL line (NW38-IVS-1) was established from this patient that reacted with autologous melanoma cells and with allogeneic human histocompatibility leukocyte antigen (HLA)-A2(-), NY-ESO-1-positive, but not NY-ESO-1-negative, melanoma cells. Screening of NY-ESO-1 transfectants with NW38-IVS-1 revealed NY-ESO-1 as the relevant CTL target presented by HLA-A2. Computer calculation identified 26 peptides with HLA-A2-binding motifs encoded by NY-ESO-1. Of these, three peptides were efficiently recognized by NW38-IVS-1. Thus, we show that antigen-specific humoral and cellular immune responses against human tumor antigens may occur simultaneously. In addition, our analysis provides a general strategy for identifying the CTL-recognizing peptides of tumor antigens initially defined by autologous antibody.
First-principles study of codoping in lanthanum bromide (2015)

Codoping of Ce-doped ${\text{LaBr}}_{3}$ with Ba, Ca, or Sr improves the energy resolution that can be achieved by radiation detectors based on these materials. Here, we present a mechanism that rationalizes this enhancement on the basis of first-principles electronic structure calculations and point defect thermodynamics. It is shown that incorporation of Sr creates neutral ${V}_{\text{Br}}\text{\ensuremath{-}}{\text{Sr}}_{\text{La}}$ complexes that can temporarily trap electrons. As a result, Auger quenching of free carriers is reduced, allowing for a more linear, albeit slower, scintillation light yield response. Experimental Stokes shifts can be related to different ${\text{Ce}}_{\text{La}}\text{\ensuremath{-}}{\text{Sr}}_{\text{La}}\text{\ensuremath{-}}{V}_{\text{Br}}$ triple complex configurations. Codoping with other alkaline as well as alkaline-earth metals is considered as well. Alkaline elements are found to have extremely small solubilities on the order of 0.1 ppm and below at 1000 K. Among the alkaline-earth metals the lighter dopant atoms prefer interstitial-like positions and create strong scattering centers, which has a detrimental impact on carrier mobilities. Only the heavier alkaline-earth elements (Ca, Sr, Ba) combine matching ionic radii with sufficiently high solubilities. This provides a rationale for the experimental finding that improved scintillator performance is exclusively achieved using Sr, Ca, or Ba. The present mechanism demonstrates that codoping of wide-gap materials can provide an efficient means for managing charge carrier populations under out-of-equilibrium conditions. In the present case dopants are introduced that manipulate not only the concentrations but also the electronic properties of intrinsic defects without introducing additional gap levels. This leads to the availability of shallow electron traps that can temporarily localize charge carriers, effectively deactivating carrier-carrier recombination channels. The principles of this mechanism are therefore not specific to the material considered here but can be adapted for controlling charge carrier populations and recombination in other wide-gap materials.
Large-Scale Point Cloud Semantic Segmentation with Superpoint Graphs (2018)

We propose a novel deep learning-based framework to tackle the challenge of semantic segmentation of large-scale point clouds of millions of points. We argue that the organization of 3D point clouds can be efficiently captured by a structure called superpoint graph (SPG), derived from a partition of the scanned scene into geometrically homogeneous elements. SPGs offer a compact yet rich representation of contextual relationships between object parts, which is then exploited by a graph convolutional network. Our framework sets a new state of the art for segmenting outdoor LiDAR scans (+11.9 and +8.8 mIoU points for both Semantic3D test sets), as well as indoor scans (+12.4 mIoU points for the S3DIS dataset).
Multirate filter banks and transform coding gain (1998)

An analytical derivation of quantization error in filter banks using additive and signal dependent noise models is presented. The coding gain over PCM is derived for both noise models. Interesting properties of coding gain in optimized filter banks with an AR(1) input signal model, asymptotic performance of multirate systems, and the analytical constraints required to achieve such performance are discussed. Connections to the recent developments of optimal subband systems are presented.
Effect of Vertical Alignment on Driver Perception of Horizontal Curves (2003)

The perception of the driver of the road features ahead is an important human factor that can considerably affect traffic safety and design consistency, and should be addressed in road design. An erroneous perception of the road can lead to actions that may compromise traffic safety. Previous studies have shown that combined horizontal and vertical alignments can cause a wrong perception of the horizontal curvature. In this paper, the hypothesis that the perception of the driver of the horizontal curvature is affected by the overlapping vertical alignment is examined analytically. Computer animation was selected as a three-dimensional presentation method of the road perspective, and was found to produce a realistic view of the road. A sample of drivers was interviewed to determine the radius of a horizontal curve on a level grade that would look equal to a radius of a horizontal curve overlapping with a vertical curve. The statistical analysis showed that the horizontal curvature looked consistently sharper when it overlapped with a crest curve and consistently flatter when it overlaps with a sag curve. Field measurements of operating speed profiles on a selected sample of combined alignments confirmed that, for the selected sample of alignments, driver behavior on horizontal curves depended on the overlapping vertical curve rather than the vertical grade of the approach tangent.