gebhart/patrepeval huggingface dataset:
Aplicación de técnicas de mastopexia con solución de Klein modificada. (2009)

Background : Breasts has always played an important role in female image. Breast ptosis is a disease which is frequently consulted to plastic surgeons. A correction was performed applying mastopexy in a minor outpatient surgery using modified Klein´s solution in minimal concentrations of lidocaine which avoid bleeding. Objectives: To describe the aesthetic results in the usage of mastopexy with Klein´s solution specifying: behavior of pain, bleeding during the surgery process, presence of complications and the satisfaction exploration in surgical operated patients. Method: A series of cases consisted of 40 patients who came to the plastic surgery consultation at the University Hospital “Dr. Gustavo Aldereguia Lima” in Cienfuegos city with breast ptosis from January 2005 to January 2006, using three mastopexy techniques (pedicle fixation, periareolar fixation, and dermal fixation). Pain was assessed during the operation and after the operation, as well as the satisfaction level of the patients and the aesthetic results obtained. Results: 75 per cent of the studied patients were among 20 and 39 years old. Klein´s solution modified with an anesthetic method was administered. 87.5 per cent stated no not feel pain showing the efficacy of the solution. Complications were minimal, only in two of the patients who presented partial wound dehiscence without any other surgical intervention. Conclusions: It was evidenced the efficacy of the Klein´s solution in the breast ptosis correction. It is recommended the usage of this solution due to the advantages it offers. It is also very economic in its usage.
Metameric effect between natural teeth and the shade tabs of a shade guide (2010)

The objective of this study was to evaluate metameric effects, that is, the dependence of the colours of teeth and shade tabs on the illuminant used. The colours of 49 teeth of 37 participants and of the corresponding shade tabs of the 3D-Master (VITA Zahnfabrik; colour match DeltaE(ab)< 2) were measured using an intra-oral spectrophotometer (VITA Easyshade). Spectral reflectance data (from 400 to 700 nm) were recorded. Commission Internationale de l'Eclairage (CIE) L*a*b* values were calculated for D65 (reference daylight), A (incandescent light), and TL84 (store/office light) as reference illuminants. A modified metamerism index (Mod-M) and hue-angle ratios were calculated to express differences between tooth and tab colour relative to the difference observed under D65 illumination. The Mod-M for teeth and tabs was greater than unity (indicating a greater colour difference relative to D65) by 57.1% for A and by 49.3% for TL84. Hue-angle ratios of teeth and tabs using the test illuminants were different from those obtained using the standard illuminant D65. If teeth and shade tab matching is conducted using daylight illumination, the colour difference may not be the same under other lighting conditions, leading to perceptible, or even unacceptable, colour differences under these conditions.
Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions. (1987)

Antibody to an estrogen inducible mouse uterine protein (Teng, C. T., Walker, M. P., Bhattacharyya, S. N., Klapper, D. G., DiAugustine, R. P., and McLachlan, J. A. (1986) Biochem. J. 240, 413-422) has been used to isolate cDNA to the messenger RNA. Analysis of the deduced primary structure and additional biochemical characterization indicates that the protein is lactotransferrin. An increase in the level of lactotransferrin mRNA of at least 300-fold can be induced in the mouse uterus by estrogen. In contrast, the mRNA is virtually undetectable in rat uterine tissue following estrogen administration. The estrogenic stimulation in mouse uterus contrasts with the known prolactin dependence in mammary gland.
Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. (1999)

Leflunomide is a novel immunosuppressive and antiinflammatory agent currently being tested for treatment of autoimmune diseases and transplant rejection. NF-kappa B is a transcription factor activated in response to a wide variety of inflammatory stimuli, including TNF, but whether leflunomide blocks NF-kappa B activation is not known. In the present report we demonstrate that treatment of a human T cell line (Jurkat) with leflunomide blocks TNF-mediated NF-kappa B activation in a dose- and time-dependent manner, with maximum inhibition at 5-10 microM. Inhibition was not restricted to TNF-induced activation, because leflunomide also inhibited NF-kappa B activation induced by other inflammatory agents, including phorbol ester, LPS, H2O2, okadaic acid, and ceramide. Leflunomide blocked the degradation of I kappa B alpha and subsequent nuclear translocation of the p65 subunit, steps essential for NF-kappa B activation. This correlated with inhibition of dual specificity-mitogen-activated protein kinase kinase as well as an Src protein tyrosine kinase, p56lck, by leflunomide. Reducing agents did not reverse the effect of leflunomide. Leflunomide also suppressed the TNF-activated NF-kappa B-dependent reporter gene expression. Our results thus indicate that leflunomide is a potent inhibitor of NF-kappa B activation induced by a wide variety of inflammatory stimuli, and this provides the molecular basis for its anti-inflammatory and immunosuppressive effects.
Immobilization in Surface-Tethered Lipid Vesicles as a New Tool for Single Biomolecule Spectroscopy (2001)

Single-molecule fluorescence studies of functional biomolecule dynamics rely on the ability to provide biologically relevant experimental conditions. Long measurement times on single molecules require their immobilization, which might modify their dynamics through interactions with the trapping medium, e.g., a glass surface or a polymer gel. In an effort to overcome this problem we have devised a new immobilization technique, based on the confinement of single biomolecules inside 100 nm surface-tethered lipid vesicles. The number of molecules in each vesicle can be accurately determined from fluorescence time traces; under our experimental conditions the number distribution of encapsulated molecules obeys a Poisson distribution with an average occupancy of 0.65 molecules per vesicle. It is further shown that the distribution of fluorescence polarization values of trapped molecules can serve as a sensitive probe for their freedom of motion and thus for the environment they sample inside the liposomes. Polarization distributions are obtained for two vesicle-entrapped labeled proteins, bovine serum albumin and adenylate kinase, and compared with distributions measured for the same proteins directly adsorbed on glass. From the significant relative narrowing of the distributions for encapsulated molecules, it is concluded that their motion within the vesicles is quite similar to free solution.
Role of psilocybin in the treatment of depression (2016)

Psilocybin is a naturally occurring alkaloid, pharmacologically similar to the classic hallucinogen lysergic acid diethylamide (LSD). Although primarily used as a recreational drug or an entheogen in particular cultural settings, recent population based studies have shown that it does not lead to serious physical or mental health problems or dependent use. In view of recent work demonstrating psilocybin's potential to increase subjective sense of wellbeing and because of its novel mechanism of 5-HT<sub>2A</sub> serotonin receptor agonism, it is being explored for possible therapeutic utility in mood and anxiety disorders.
An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1) (1980)

A variant subline (KG-1a) of the human acute myelogenous leukemia (AML) cell line (KG-1) has been isolated. The cells retain the same constitutive markers as the parent line, including HLA antigens, isoenzymes, and karyotype. The cells from the subline are morphologically and histochemically undifferentiated blast cells, while the parent cells and several of its clones are at the myeloblast and promyelocyte stages of development. The variant cells do not respond to colony-stimulating factor (CSF), and they do not express the human la antigen, nor a recently characterized AML antigen. The parent KG-1 cells are stimulated to proliferate in the presence of CSF and the cells express the la and AML antigen. Variant AML cell lines, such as KG-1a, will be useful in vitro models for investigating cellular response to CSF and for studying antigen expression in leukemic cells.
The effect of thalidomide on arachidonic acid metabolism in human polymorphonuclear leukocytes and platelets (1986)

The effect of thalidomide on the metabolism of arachidonic acid by purified washed human platelets and polymorphonuclear leukocytes was examined. The drug was found to be without effect under the conditions used. The action of thalidomide cannot therefore be attributed to a direct inhibition of prostaglandin or leukotriene biosynthesis.
Incidencia de agenesia dental en perros Beagle. Resultados preliminares (2011)

Forty-nine Beagle dogs coming from CENPALAB were maintained under
the same coexistence, feeding and handling regime in the Bioterio of
Medicine High School “Victoria de Giron” tributary to studies of dental
implant all them. The aim of this paper was to know of dental agenesis
incidence in this race. Buccal clinical exams, previous to implants surgeries were carried out in all animals which were anesthetized with
Propofol 1% for endovenous via and the taking of X-rays, using a digital
X-rays of high frequency equipment was realized as definitive diagnosis.
Eigth dogs presented dental agenesis. Most of the dental agenesis was
classified as hipodontia with the 8 cases presentation. This congenital
absence was presented in jaw only and it affected specifically to
premolars in all cases. We concluded that general incidence was of
16,3% of the studied dogs population's total.
Antiinflammatory effect of Rho kinase blockade via inhibition of NF‐κB activation in rheumatoid arthritis (2008)

The results of this study provide new evidence that blockade of ROK inhibits activation of NF-kappaB and production of proinflammatory cytokines, suggesting a critical role of ROK in the synovial inflammation of RA. Specific inhibition of ROK may be a novel therapeutic approach in RA.
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs (2005)

TNF family members and their receptors contribute to increased gene expression for inflammatory processes and intracellular cascades leading to programmed cell death, both via activation of NF-kappaB. TNF receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins binding to various receptors of the TNFR family. In an attempt to delineate the role of individual TRAFs, we compared NF-kappaB activation by CD40(wt) and CD40 mutants with different TRAF recruitment patterns. Recognized only recently, NF-kappaB signaling occurs at least via two different pathways. Each pathway results in nuclear translocation of two different Reldimers, the canonical p50/RelA and the noncanonical p52/RelB. Here, we show that via TRAF6, CD40 mediates only the activation of the canonical NF-kappaB pathway. Via TRAF2/5, CD40 activates both the canonical and the noncanonical NF-kappaB pathways. We observed that TRAF3 specifically blocked the NF-kappaB activation via TRAF2/5. This inhibitory effect of TRAF3 depends on the presence of an intact zinc finger domain. Paradoxically, suppression of TRAF2/5-mediated NF-kappaB activation by TRAF3 resulted in enhanced transcriptional activity of TRAF6-mediated canonical NF-kappaB emanating from CD40. We also observed that 12 TNFR family members (p75TNFR, LTbetaR, RANK, HVEM, CD40, CD30, CD27, 4-1BB, GITR, BCMA, OX40, and TACI) are each capable of activating the alternative NF-kappaB pathway and conclude that TRAF3 serves as a negative regulator of this pathway for all tested receptors.
CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin (2001)

The chemokine thymus and activation-regulated chemokine (TARC; CCL17) is displayed by cutaneous (but not intestinal) venules, and is thought to trigger vascular arrest of circulating skin homing memory T cells, which uniformly express the TARC receptor CC chemokine receptor (CCR)4. Cutaneous T cell-attracting chemokine (CTACK; CCL27), expressed by skin keratinocytes, also attracts cutaneous memory T cells, and is hypothesized to assist in lymphocyte recruitment to skin as well. Here we show that chronic cutaneous inflammation induces CD4 T cells expressing E-selectin binding activity (a marker of skin homing memory cells) in draining lymph node, and that these E-selectin ligand+ T cells migrate efficiently to TARC and to CTACK. In 24 h in vivo homing assays, stimulated lymph node T cells from wild-type mice or, surprisingly, from CCR4-deficient donors migrate efficiently to inflamed skin; and an inhibitory anti-CTACK antibody has no effect on wild-type lymphocyte recruitment. However, inhibition with anti-CTACK monoclonal antibody abrogates skin recruitment of CCR4-deficient T cells. We conclude that CTACK and CCR4 can both support homing of T cells to skin, and that either one or the other is required for lymphocyte recruitment in cutaneous delayed type hypersensitivity.
Microwave Discharge Cavities Operating at 2450 MHz (1965)

Five simple microwave cavities for producing discharges in gases were tested in He and H2 at pressures from 1 μ to 1 atm. Three of the cavities are commonly used, and two have been recently designed. One of the newly designed cavities offered a considerable improvement over early models with respect to compactness, ease of attachment to the system, and efficiency.
In Vino Vitalis? Compounds Activate Life-Extending Genes (2003)

LONGEVITY RESEARCHSeveral naturally occurring small molecules extend the life of yeast cells by approximately 70% and offer some protection to cultured human cells exposed to radiation, researchers reported online in Nature on 24 August. The molecules belong to a family of chemicals known as polyphenols, some of which are prominent components of grapes, red wine, olive oil, and other foods.
Heat‐shock tagging: a simple method for expression and isolation of plant genome DNA flanked by T‐DNA insertions (2000)

This paper describes expression profiles of the Arabidopsis HSP18.2 heat-shock gene promoter by using three different reporter genes, and the application of this promoter to a method we have developed to drive heat-shock-dependent transcription of plant genome DNA flanked by T-DNA insertions. We show that, irrespective of the location of the T-DNA insertion, an HSP18.2 promoter towards the left border of the T-DNA effectively induces transcription of flanking genome sequences in response to heat shock. If polyadenylated, tagged transcripts can be easily identified by RT-PCR.
A WDM cross-connected star multihop optical network (2003)

The authors propose a star topology for multihop lightwave networks in which the conventional N*N passive star coupler is replaced by fixed wavelength division multiplexing (WDM) cross-connects. The proposed topology overcomes three major limitations of the conventional star topology. First, it reduces the number of wavelengths needed in a (p,k) ShuffleNet from kp/sup k+1/ wavelengths in the conventional topology to p wavelengths in the proposed one. Second, the signal power loss due to the 1/N power splitting at the star coupler no longer exists in the WDM cross-connects and, therefore, the restriction on the supported number of users by the star network is alleviated. Third, it completely eliminates the need for wavelength filtering at the input to the receivers, as is the case in the conventional star topology. The use of 2*2 WDM lapped couplers as a cheap WDM cross-connect for a (2,k) ShuffleNet is investigated. A p*p star coupler followed by p fiber Fabry-Perot filters can be used as a p*p WDM cross-connect for a (p,k) ShuffleNet at the expense of using p/sup 2/ rather than p wavelengths.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of phospholipase C and apolipophorin III on the structure and stability of lipophorin subspecies. (1994)

Four distinct subspecies of the insect hemolymph lipoprotein, lipophorin, that range in diacylglycerol (DAG) content from approximately 100 to 1000 molecules per particle, were treated with phospholipase C. Lipid analysis demonstrated that both phosphatidylcholine and phosphatidylethanolamine were hydrolyzed to DAG. Phospholipase C was used to remove 74-82% of the phospholipid of different lipophorins and these were analyzed for aggregation. Low density lipophorin (LDLp), the largest subspecies, with a diameter of approximately 23 nm, developed turbidity (monitored by sample absorbance at 340 nm) suggesting the formation of lipoprotein aggregates. High density lipophorin-adult (HDLp-A) and high density lipophorin-wanderer 1 (HDLp-W1) also displayed an increase in A340 when incubated with phospholipase C, although the maximal increase observed was considerably less than that for LDLp on a per particle basis. Phospholipase C caused only a minimal increase in A340 in a fourth subspecies, high density lipophorin-wanderer 2 (HDLp-W2), which contains an even lower amount of DAG. Electron microscopy was used to evaluate changes in particle morphology as a result of phospholipid depletion. HDLp-W2 and HDLp-W1 showed signs of progressive aggregation and particle fusion. A similar aggregation/fusion was seen in the case of high density lipophorin adult (HDLp-A) while LDLp samples contained multiple aggregation/fusion foci and resultant very large particles. In the presence of exogenous apolipophorin III (apoLp-III), phospholipase C-induced lipophorin aggregation/fusion was prevented. Electron microscopy of LDLp and HDLp-A samples revealed that apoLp-III-stabilized, phospholipase C-treated particles had a morphology similar to that of control particles.(ABSTRACT TRUNCATED AT 250 WORDS)
Detection and Characterization of Plasmids in Pseudomonas aeruginosa Strain PAO (1973)

Using a variety of techniques, it has been established that the sex factor FP2 has a density of 1.717 g/cm(3) (corresponding to a guanine plus cytosine [G + C] content of 58%) and a mean circular contour length of 28.5 +/- 0.6 mum (corresponding to a molecular weight of 59 x 10(6)). Another sex factor FP39 has a density of 1.719 g/cm(3) (corresponding to a G + C content of 60%) and a mean circular contour length of 26.5 +/- 0.5 mum (corresponding to a molecular weight of 55 x 10(6)). It appears that all, or nearly all, of the FP sex factor deoxyribonucleic acid occurs as covalent circular molecules under the conditions employed. In addition, these procedures have been used to demonstrate that strain PAO, a naturally occurring female (i.e., FP(-)) strain of Pseudomonas aeruginosa, harbors a number of cryptic plasmids having similar densities to the bulk of the cell deoxyribonucleic acid (1.726 g/cm(3)) and occurring as covalent circular molecules.
Total synthesis of the tumor-associated Lex family of glycosphingolipids (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of the tumor-associated Lex family of glycosphingolipidsK. C. Nicolaou, T. J. Caulfield, H. Kataoka, and N. A. StylianidesCite this: J. Am. Chem. Soc. 1990, 112, 9, 3693–3695Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00165a084https://doi.org/10.1021/ja00165a084research-articleACS PublicationsRequest reuse permissionsArticle Views2201Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
AMINO ACID DATING (1985)

Investigation of amino acids in fossils over the past thirty years has revealed that residual amino acids may exist in fossils from throughout the Phanerozoic portion of the geologic column, that the amino acid pattern in a given fossil changes with age due to differences in stability among the twenty amino acids of which proteins are constructed, and that the ratio of right-handed to left-handed forms (D/L ratio) of amino acids increases with age from zero in the proteins of living organisms to the ratios which are characteristic of amino acids produced synthetically (the racemic ratios). The possibilities for using these characteristics as a means for determining fossil age are frustrated by variations of the amino acid pattern among individual living organisms of the same species, and by the critical dependency of the racemization probability for an amino acid molecule on temperature, water concentration in the environment, alkalinity of the environment, association with other molecules (free state or a component of a macromolecule), size of the macromolecule of which it may be a component, specific location in the structure of a macromolecule, catalytic effect of clay surfaces with which it may be associated, presence of aldehydes and metal ions, concentration of buffer compounds in the environment, and ionic strength of the environment. In spite of these complications, fossils of similar characteristics, and which have experienced similar conditions of preservation, can be placed in a relative age sequence on the basis of D/L ratios. Due to the strong dependency of racemization rates on temperature, water concentration, and alkalinity, uncertainties regarding conditions of preservation can leave amino-acid-based age relationships among even similar fossils open to question. At the present time there is insufficient knowledge concerning the effective average racemization rate in a fossil as a function of time to justify dependence on D/L ratios for a quantitative determination of age. The survival of amino acids in fossils from the Paleozoic era and the trend for the apparent racemization rate constant to decrease with conventional fossil age assignment raise a serious question concerning the accuracy with which radioisotope age data have been used to represent the real-time history of fossils.