gebhart/patrepeval huggingface dataset:
Socioeconomic factors in cancer in Sweden (2003)

It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and women in 6 socioeconomic groups based on the Swedish Family-Cancer Database. Persons had to be identified with the same socioeconomic status in the census of years 1960 and 1970, or of years 1960, 1970 and 1980; the comparison group was all people according to the same censuses. Cancers were followed from years 1970 to 1998 or from 1980 to 1998. Both increased and decreased SIRs were found, and a consistent pattern emerged, although the overall SIRs for cancer did not differ much, the lowest being for farmers (0.85) and the highest for professional men (1.07) and women (1.11). At individual sites, manual workers were at risk of tobacco-, alcohol- and occupation- and human papilloma virus-related cancers and at a decreased risk at most other cancers. Manual workers and farmers showed an excess of stomach cancer; professionals had an excess of melanoma and squamous cell skin cancer. Male and female SIRs correlated highly for manual and blue-collar workers and for professionals. The overall population-attributable fraction for selected sites was 16.7% for men and 10.9% for women and it was highest, over 50%, for lung cancer in both genders.
The core Dravet syndrome phenotype (2011)

Dravet syndrome was described in 1978 by Dravet (1978) under the name of severe myoclonic epilepsy in infancy (SMEI). The characteristics of the syndrome were confirmed and further delineated by other authors over the years. According to the semiologic features, two forms have been individualized: (1) the typical, core, SMEI; and (2) the borderline form, SMEIB, in which the myoclonic component is absent or subtle. Clinical manifestations at the onset, at the steady state, and during the course of the disease are analyzed in detail for the typical Dravet syndrome, and the differential diagnosis is discussed. Onset in the first year of life by febrile or afebrile clonic and tonic-clonic, generalized, and unilateral seizures, often prolonged, in an apparently normal infant is the first symptom, suggesting the diagnosis. Later on, multiple seizure types, mainly myoclonic, atypical absences, and focal seizures appear, as well as a slowing of developmental and cognitive skills, and the appearance of behavioral disorders. Mutation screening for the SCN1A gene confirms the diagnosis in 70-80% of patients. All seizure types are pharmacoresistent, but a trend toward less severe epilepsy and cognitive impairment is usually observed after the age of 5 years.
Fluid Limits and Diffusion Approximations for Integrated Traffic Models (2005)

In this paper we consider a stochastic model describing the varying number of flows in a network. This model features flows of two types, namely file transfers (with fixed volume) and streaming traffic (with fixed duration), and extends the model of Key, Massoulié, Bain and Kelly [23] by allowing more general bandwidth allocation criteria. We analyse the dynamics of the system under a fluid scaling, and show Lyapunov stability of the fluid limits under a natural stability condition. We provide natural interpretations of the fixed points of these fluid limits. We then compare the fluid dynamics of file transfers under (i) balanced multipath routing and (ii) parallel, uncoordinated routing. We show that for identical traffic demands, parallel uncoordinated routing can be unstable while balanced multipath routing is stable. Finally, we identify multi-dimensional Ornstein-Uhlenbeck processes as second-order ap-proximations to the first-order fluid limit dynamics. 1
Novel vascular sealing device for closure of percutaneous vascular access sites (1998)

To investigate the hemostatic capabilities of a novel vascular sealing device consisting of a balloon catheter and procoagulant, vascular sheaths were placed percutaneously in the femoral arteries of dogs. The sealing device was evaluated using the balloon catheter alone in six femoral arteries and with the addition of a procoagulant, in 21 femoral arteries. The balloon catheter alone was successfully deployed in six of six femoral arteries achieving immediate hemostasis. In a second study in which the procoagulant was delivered following balloon placement, the sealing device was successfully deployed and hemostasis was achieved in 20 of 21 attempts (95%) despite removal of the balloon catheter. In a subset of fully anticoagulated animals, hemostasis was achieved in the sealing device-treated arteries at 6.5 ± 3.4 minutes, but in none of the controls (P < 0.001). This novel vascular sealing device successfully achieves rapid hemostasis in normal and anticoagulated dogs following percutaneous vascular procedures. Cathet. Cardiovasc. Diagn. 45:82–88, 1998. © 1998 Wiley-Liss, Inc.
Second-harmonic tomography of tissues:?errata (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Yici Guo, P. P. Ho, H. Savage, D. Harris, P. Sacks, S. Schantz, Feng Liu, N. Zhadin, and R. R. Alfano, "Second-harmonic tomography of tissues:?errata," Opt. Lett. 23, 733-733 (1998) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Letters (1995)

COMPARING DRESSINGS FOR DIABETIC FOOT ULCERS HYDROGEL AND NAPPY RASH ADVANCES IN THE USE OF LASERS IN DERMATOLOGY.
Application of fuzzy sets for the analysis of complex scenes (1978)

A scene analysis system should be able to work with imprecise data and should integrate pieces of evidence collected from different knowledge sources. It is shown in this paper that fuzzy set theory can be applied to scene analysis for considering the imprecise data and for employing approximate reasoning.
Insulin Resistance and Human Disease: A Short History (1998)

The notion that tissue resistance to insulin might play an important role in certain disease states is approximately 60 years old. However, recognition of its central role in this regard is a relatively recent phenomenon. In this review an effort has been made to trace a brief history of insulin resistance from its inception to its current position as the fundamental abnormality in both type 2 diabetes and Syndrome X.
Effect of Heating on the Functional Properties of Ovotransferrin (1979)

Journal Article Effect of Heating on the Functional Properties of Ovotransferrin Get access Ryo Nakamura, Ryo Nakamura Laboratory of Food Science and Nutrition, Faculty of Agriculture, Tottori University, Koyama, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Osamu Umemura, Osamu Umemura Laboratory of Food Science and Nutrition, Faculty of Agriculture, Tottori University, Koyama, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Hidehiro Takemoto Hidehiro Takemoto Laboratory of Food Science and Nutrition, Faculty of Agriculture, Tottori University, Koyama, Tottori, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 43, Issue 2, 1 February 1979, Pages 325–330, https://doi.org/10.1080/00021369.1979.10863449 Published: 01 February 1979 Article history Received: 01 September 1978 Published: 01 February 1979
Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis. (1978)

An acute phase of experimental autoimmune myasthenia gravis (EAMG) occurs transiently early in the immune response of Lewis rats to nicotinic acetylcholine receptors (AChR) when Bordetella pertussis is used as adjuvant. It is characterized by a destructive cellular attack directed at the postsynaptic membranes of muscle. Acute EAMG can be passively transferred to normal rats by IgG from serum of rats with chronic EAMG. In the present study, acute EAMG, induced either by passive transfer of syngeneic antibodies or by active immmunization, was inhibited in rats depleted of complement by treatment with cobra venom factor (CoF). Furthermore, passive transfer of antibodies in excess of the muscle's content of AChR was without any measurable effect in rats treated with CoF. Although 60% of the muscle's AChR was complexed with antibody, there was no reduction in the muscle's content of AChR, and neuromuscular transmission was not compromised as judged electromyographically by curare sensitivity. These data imply that redistribution, accelerated degradation, and impairment of the ionophore function of AChR, effects of antibodies described in vitro on extrajunctional AChR, do not play a significant role in vivo in impairing neuromuscular transmission in an intact neuromuscular junction. Complement appears to be a critical mediator of anti-AChR antibodies' pathogenicity in vivo.
Donors of HNO (2005)

Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.
SYNTHESIS OF SOME 2-(ACETOPHENON- HYDRAZIN)-THIAZOLES AND 2-(4-THIAZOLYL- METHYNHYDRAZIN)-THIAZOLES AS POTENTIAL ANTIBACTERIAL AND ANTIFUNGAL AGENTS (2010)

A new series of 2-(acetophenon-hydrazin)-thiazoles 4a-x and 2-(4-thiazolylmethine-hydrazin)-thiazoles 5a-c were synthesized starting from various thiosemicarbazones by the reaction with different α(γ))-halocarbonyle compounds. The newly synthesized compounds were characterized by IR, 1 H-NMR and mass spectral studies. Rezumat Au fost sintetizate noi serii de 2-(acetofenon-hidrazin)-tiazoli 4a-x si de 2-(4tiazolil-metinhidrazin)-tiazoli 5a-c pornind de la diferite tiosemicarbazone prin reacţia cu diferiţi compusi α(γ))-halocarbonilici. Noii compusi sintetizaţi au fost caracterizaţi prin IR, 1 H-RMN si studii spectrale de masa.
On top-k recommendation using social networks (2012)

Recommendation accuracy can be improved by incorporating trust relationships derived from social networks. Most recent work on social network based recommendation is focused on minimizing the root mean square error (RMSE). Social network based top-k recommendation, which recommends to a user a small number of items at a time, is not well studied. In this paper, we conduct a comprehensive study on improving the accuracy of top-k recommendation using social networks. We first show that the existing social-trust enhanced Matrix Factorization (MF) models can be tailored for top-k recommendation by including observed and missing ratings in their training objective functions. We also propose a Nearest Neighbor (NN) based top-k recommendation method that combines users' neighborhoods in the trust network with their neighborhoods in the latent feature space. Experimental results on two publicly available datasets show that social networks can significantly improve the top-k hit ratio, especially for cold start users. Surprisingly, we also found that the technical approach for combining feedback data (e.g. ratings) with social network information that works best for minimizing RMSE works poorly for maximizing the hit ratio, and vice versa.
Synthesis of 5- and 6-Carboxy-X-rhodamines (2008)

An efficient route is reported to 5- and 6-carboxy-X-rhodamines (compounds 1 and 2) that contain multiple n-propylene or gamma,gamma-dimethylpropylene groups bridging terminal nitrogen atoms and the central xanthene core. Gram quantities of these dyes are synthesized from inexpensive starting materials. The isolated products are activated by selective transformation of the carboxylic acid group into N-hydroxysuccinimidyl esters in situ and then conjugated with an amino group of a molecule of interest.
Attosecond twin-pulse control by generalized kinetic heterodyne mixing (2011)

Attosecond double-pulse (twin-pulse) production in high-order harmonic generation is manipulated by a combination of two-color and carrier-envelope phase-control methods. As we show in numerical simulations, both relative amplitude and phase of the double pulse can be independently set by making use of multidimensional parameter control. Two technical implementation routes are discussed: kinetic heterodyning using second-harmonic generation and split-spectrum phase-step control.
Dendritic Nanowire Ultraviolet Laser Array (2003)

Self-organized dendritic crystal growth is explored to assemble uniform semiconductor nanowires into highly ordered one-dimensional microscale arrays that resemble comb structures. The individual ZnO nanowires have uniform diameters ranging from 10 to 300 nm. They are evenly spaced on a stem with a regular periodicity of 0.1-2 micrometer. Under optical excitation, each individual ZnO nanowire serves as a Fabry-Perot optical cavity, and together they form a highly ordered nanowire ultraviolet laser array.
Implementation of a wireless pulse oximeter based on wrist band sensor (2010)

In order to develop a wrist band pulse oximeter, the detected light intensities and effective transmission depth of reflectance oximetry are investigated by analyzing the light propagation through tissue. A reflectance probe is fabricated based on the analytical results. An oxygen saturation measurement system is also implemented and some preliminary experiments are conducted. The experimental results have confirmed the feasibility of this wrist-band oximeter. Home healthcare can be ensured by transmitting the realtime measurements through wireless technology to the community monitoring system.
Learning from strong leadership (2013)

Politics in the state and federal sphere is shaping the health landscape - and the future of our professions - in so many ways.
Nicotine Transdermal Systems (1993)

Transdermal nicotine is effective for patients who are motivated to quit smoking and receive concomitant behavior support.
A new look at marine simultaneous sources (2008)

Cost is one of the fundamental factors that determines where and how a seismic survey will be conducted. Moreover, the cost of 3D seismic acquisition and processing often plays a significant role in determining whether or not a prospect is economic. Unit costs of seismic data acquisition and processing have dropped dramatically as the technology has matured; however, these economies have raised demand for larger and more complex acquisition plans. More than ever, there is a great need to gain efficiency. In this article, I discuss a field experiment carried out to test the feasibility of employing marine sources activated simultaneously. Simultaneous source firing has long been recognized as a possible strategy for achieving dramatic cost reductions in seismic data acquisition. This approach is novel in that it does not require source-signature encoding (although such encoding combined with this approach is beneficial), but, rather, relies on spatial-source positioning to allow for separation of the signals in subsequent data processing. Appropriate data processing sequences separate the interfering signals quite effectively, and this approach may be an attractive economic option for acquiring large 3D surveys, particularly when multiple vessels are already employed as in today's multiazimuth surveys.
Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells (2013)

Transfer RNAs (tRNAs) are typically considered housekeeping products with little regulatory function. However, several studies over the past 10 years have linked tRNA misregulation to cancer. We have previously reported that tRNA levels are significantly elevated in breast cancer and multiple myeloma cells. To further investigate the cellular and physiological effects of tRNA overexpression, we overexpressed tRNAi(Met) in two human breast epithelial cell lines. We then determined tRNA abundance changes and performed phenotypic characterization. Overexpression of tRNAi(Met) significantly altered the global tRNA expression profile and resulted in increased cell metabolic activity and cell proliferation. Our results extend the relevance of tRNA overexpression in human cells and underscore the complexity of cellular regulation of tRNA expression.
The Regulatory Role of Invariant NKT Cells in Tumor Immunity (2015)

Invariant natural killer T (iNKT) cells are a unique population of T lymphocytes, which lie at the interface between the innate and adaptive immune systems, and are important mediators of immune responses and tumor surveillance. iNKT cells recognize lipid antigens in a CD1d-dependent manner; their subsequent activation results in a rapid and specific downstream response, which enhances both innate and adaptive immunity. The capacity of iNKT cells to modify the immune microenvironment influences the ability of the host to control tumor growth, making them an important population to be harnessed in the clinic for the development of anticancer therapeutics. Indeed, the identification of strong iNKT-cell agonists, such as α-galactosylceramide (α-GalCer) and its analogues, has led to the development of synthetic lipids that have shown potential in vaccination and treatment against cancers. In this Masters of Immunology article, we discuss these latest findings and summarize the major discoveries in iNKT-cell biology, which have enabled the design of potent strategies for immune-mediated tumor destruction.
An Electrohydraulic Knee-Torque Controller for a Prosthesis Simulator (1977)

A new approach for evaluating advanced concepts for knee-joint control in above-knee prostheses involves the use of a simulator prosthesis which can be worn by an amputee and controlled electronically to emulate proposed future prostheses. A critical element in this system is the knee-torque controller. Realization of a powerful, lightweight, easily controlled transducer was essential to the successful development of the simulator system. This paper presents the design of such a controller and evaluates its performance. Brief examples of studies in which the new system has been applied are given. The proven viability of the device suggests that similar actuators might aid other prosthesis/orthesis studies.
An In‐vitro Study on Regeneration of Human Nucleus Pulposus by Using Gelatin/Chondroitin‐6‐Sulfate/Hyaluronan Tri‐copolymer Scaffold (2005)

Tissue engineering approaches for treating degenerative intervertebral discs aim to promote tissue regeneration then retard or even reverse the degenerative process. A gelatin/chondroitin-6-sulfate/hyaluronan tri-copolymer was developed to serve as a bioactive scaffold that could help human nucleus pulposus (NP) cells to preserve their cell viability/proliferation and promote matrix synthesis. Each scaffold was seeded with 1 x 10(6) monolayer-expanded human NP cells and then cultured in vitro. Over a 4-week cultivation period, cell-scaffold hybrids demonstrated active cell viability/proliferation and a progressive increase in net production of glycosaminoglycans. In comparison to monolayer cells, scaffold-cultured cells showed significantly higher mRNA expression in collagen II, aggrecan, Sox9, TGFbeta1, and TIMP1. Expression of mRNA was significantly suppressed in collagen I, collagen X, IL1, and Fas-associating death domain protein. Histological studies showed newly synthesized glycosaminoglycans deposits and collagen II in scaffolds. These results indicate that the tri-copolymer scaffold could be considered as a promising bioactive scaffold for regenerating human NP.
Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. (1997)

The peripheral production of leptin by adipose tissue and its putative effect as a signal of satiety in the central nervous system suggest that leptin gains access to the regions of the brain regulating energy balance by crossing the brain capillary endothelium, which constitutes the blood-brain barrier in vivo. The present experiments characterize the binding and internalization of mouse recombinant leptin in isolated human brain capillaries, an in vitro model of the human blood-brain barrier. Incubation of 125I-leptin with isolated human brain capillaries resulted in temperature-dependent binding: at 37 degrees C, approximately 65% of radiolabeled leptin was bound per milligram of capillary protein. Two-thirds of the bound radioactivity was resistant to removal by acid wash, demonstrating endocytosis of 125I-leptin into capillary cells. At 4 degrees C, binding to isolated capillaries was reduced to approximately 23%/mg of protein, the majority of which was acid wash resistant. Binding of 125I-leptin to brain capillary endothelial plasma membranes was saturable, described by a two-site binding model with a high-affinity dissociation constant of 5.1+/-2.8 nM and maximal binding capacity of 0.34+/-0.16 pmol/mg of membrane protein. Addition of porcine insulin or insulin-like growth factor at a final concentration of 100 nM had a negligible effect on leptin binding. These results provide evidence for a leptin receptor that mediates saturable, specific, temperature-dependent binding and endocytosis of leptin at the human blood-brain barrier.
Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches (2008)

The root cause of sickle cell disease is a single beta-globin gene mutation coding for the sickle beta-hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte. A multifaceted pathophysiology, triggered by erythrocyte injury induced by the sickle hemoglobin polymer, and encompassing more general cellular and tissue damage caused by hypoxia, oxidant damage, inflammation, abnormal intracellular interactions, and reduced nitric oxide bioavailability, sets off the events recognized clinically as sickle cell disease. This disease is a group of related disorders where sickle hemoglobin is the principal hemoglobin species. All have varying degrees of chronic hemolytic anemia, vasculopathy, vasoocclusive disease, acute and chronic organ damage, and shortened life span. Its complex pathophysiology, of which we have a reasonable understanding, provides multiple loci for potential therapeutic intervention.