gebhart/patrepeval huggingface dataset:
Efficient production of C60 (buckminsterfullerene), C60H36, and the solvated buckide ion (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient production of C60 (buckminsterfullerene), C60H36, and the solvated buckide ionR. E. Haufler, J. Conceicao, L. P. F. Chibante, Y. Chai, N. E. Byrne, S. Flanagan, M. M. Haley, S. C. O'Brien, C. Pan, and . et al.Cite this: J. Phys. Chem. 1990, 94, 24, 8634–8636Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/j100387a005https://doi.org/10.1021/j100387a005research-articleACS PublicationsRequest reuse permissionsArticle Views2581Altmetric-Citations872LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Performance Improvement Effect of the Convergence Rate and Interference Cancellation in SLC (1999)

This paper showed the convergence rate and the performance of interference cancellation using Applebaum and DMI algorithms in adaptive sidelobe canceller. Applebaum algorithm is used widely due to simplicity but it has a slow convergence rate and the problem of eigenvalue spread. DMI algorithm converges rapidly but has computational load and hardware complexity. We compared the performance and complexity using Applebaum and DMI algorithms in Adaptive SLC that requires rapid convergence rate and the performance and conclude that DMI algorithm is more efficient for adaptive SLC.
VEGF/Flk1 Signaling Cascade Transactivates Etv2 Gene Expression (2012)

Previous reports regarding the genetic hierarchy between Ets related protein 71 (Er71/Etv2) and Flk1 is unclear. In the present study, we pursued a genetic approach to define the molecular cascade between Etv2 and Flk1. Using a transgenic Etv2-EYFP reporter mouse, we examined the expression pattern of Etv2 relative to Flk1 in the early conceptus. Etv2-EYFP was expressed in subset of Flk1 positive cells during primitive streak stages, suggesting that Flk1 is upstream of Etv2 during gastrulation. Analysis of reporter gene expression in Flk1 and Etv2 mutant mice further supports the hypothesis that Flk1 is necessary for Etv2 expression. The frequency of cells expressing Flk1 in Etv2 mutants is only modestly altered (21% decrease), whereas expression of the Etv2-EYFP transgenic reporter was severely reduced in the Flk1 null background. We further demonstrate using transcriptional assays that, in the presence of Flk1, the Etv2 promoter is activated by VEGF, the Flk1 ligand. Pharmacological inhibition studies demonstrate that VEGF mediated activation is dependent on p38 MAPK, which activates Creb. We identify the VEGF response element in the Etv2 promoter and demonstrate that Creb binds to this motif by EMSA and ChIP assays. In summary, we provide new evidence that VEGF activates Etv2 by signaling through Flk1, which activates Creb through the p38 MAPK signaling cascade.
Measuring breathlessness during histamine challenge: a simple standardized procedure in asthmatic patients (1999)

One of the problems in research on symptom perception during histamine challenge has been the difficulty in finding both a valid and practical parameter of the "perceptiveness" for bronchoconstriction in a subject. The purpose of this study was to validate whether the slope in the linear regression model between stimulus and sensation during histamine challenge is an appropriate index for the "perceptiveness" for bronchoconstriction by comparing it with the classical Stevens' law. One hundred and thirty-four asthmatic patients were included in the study and underwent a bronchial challenge with histamine. The relationship between the change in visual analogue scale (VAS) values and the change in forced expiratory volume in one second (FEV1) as percentage of baseline value was analysed by determining both the exponent n in deltaVAS=k x (%deltaFEV1)n and the slope alpha in deltaVAS=k + alpha(%deltaFEV1). The best-fitting line of both the exponential and the linear regression model were determined by the least-squares method in which the percentage explained variation (R2) was compared. The median value of R2 of the exponential regression line and the linear regression line was 0.76 and 0.83, respectively, and significantly different. The Spearman rank correlation coefficient between exponent n in the exponential model deltaVAS=k x (%deltaFEV1)n and the slope alpha in the linear regression model deltaVAS=k + alpha(%deltaFEV1) was 0.87 (95% confidence interval 0.83-0.91). On the basis of the results, it was concluded that the linear regression coefficient can be used as a valid expression to describe the "perceptiveness" of an asthmatic subject instead of Stevens' power function during histamine challenge.
Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)-a veterinary cooperative oncology group (VCOG) consensus document (2009)

Standardized assessment of response to therapy for lymphoma in dogs is lacking, making critical comparisons of treatment protocols difficult. This Veterinary Cooperative Oncology Group (VCOG) consensus document, based on the recommendations of a subcommittee of ACVIM board-certified veterinary oncologists, was unanimously adopted at the 29th Annual Conference of the Veterinary Cancer Society (VCS) by the VCOG membership. It has integrated guidance from the response assessment criteria established for lymphoma in human patients using standards available in routine veterinary oncology practices that are simple, repeatable and consistently applicable. These guidelines are intended only for use in dogs, where peripheral lymphadenopathy represents the principal component of their disease and as such do not critically assess extranodal disease (e.g., primary cutaneous, central nervous system, gastrointestinal). It is hoped these guidelines will be widely adopted and serve to facilitate the comparison of current and future treatment protocols used in the therapy of dogs.
A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest [published erratum appears in Blood 1991 Oct 1;78(7):1899] (1991)

A major feature of human immunodeficiency virus (HIV) infection is disordered B-cell function, which paradoxically includes both pathologic overactivity (elevated serum antibodies, lymphadenopathy, and increased risk for lymphoma) and underactivity (impaired antibody immunity, particularly to bacterial polysaccharide antigens). B-cell immune dysfunction contributes significantly to HIV-related morbidity and also represents an obstacle to eventual definitive treatment by anti-HIV immunization. Our laboratory has recently identified in normal B-cell populations certain VH gene subfamilies with a developmentally regulated pattern of utilization. In particular, B cells bearing rearranged VH3L were rare in the germinal center but uniformly abundant in the blood and lymphoid mantle zone. We used this index gene subfamily as a clonal criterion for the pattern of B-cell development in lymphocytes of HIV-positive individuals. In a series of 19 HIV-positive subjects, a striking deficit of VH3L B cells was observed; in contrast, none of the 16 normal subjects showed this abnormality. Other VH subfamilies (VH1N, VH4/6, and VH5N) were unaffected in the HIV-positive patients. This VH3L clonal deficit and other recent phenotype and histopathologic findings suggest that the general B-cell dysfunction in HIV is due to a discreet maturational arrest at the germinal center stage.
Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications (2011)

Injectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical operation in a minimally invasive way, causing smaller scar size and less pain for patients. Therefore, they have found a variety of biomedical applications, such as drug delivery, cell encapsulation, and tissue engineering. This critical review systematically summarizes the recent progresses on biodegradable and injectable hydrogels fabricated from natural polymers (chitosan, hyaluronic acid, alginates, gelatin, heparin, chondroitin sulfate, etc.) and biodegradable synthetic polymers (polypeptides, polyesters, polyphosphazenes, etc.). The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification. The gelation and biodegradation which are two key factors to affect the cell fate or drug delivery are highlighted. A brief outlook on the future of injectable and biodegradable hydrogels is also presented (326 references).
Engineering the Phase Front of Light with Phase-Change Material Based Planar lenses (2015)

A novel hybrid planar lens is proposed to engineer the far-field focusing patterns. It consists of an array of slits which are filled with phase-change material Ge2Sb2Te5 (GST). By varying the crystallization level of GST from 0% to 90%, the Fabry-Pérot resonance supported inside each slit can be spectrally shifted across the working wavelength at 1.55 µm, which results in a transmitted electromagnetic phase modulation as large as 0.56π. Based on this geometrically fixed platform, different phase fronts can be constructed spatially on the lens plane by assigning the designed GST crystallization levels to the corresponding slits, achieving various far-field focusing patterns. The present work offers a promising route to realize tunable nanophotonic components, which can be used in optical circuits and imaging applications.
Process Optimization Using Design of Experiments (1997)

The use of design of experiments (DOE) software and methods allowed the authors to quantify the effects of changes in coating process conditions on the quality and performance of film-coated tablets. The application of DOE has the potential to allow rapid optimization of coating performance in a wide range of customer application environments to meet changing customer needs. Aqueous film-coating processes can influence many quality aspects of the final coated product, including coated-tablet moisture content, surface roughness, gloss, coating efficiency, and coating uniformity. Colorcon’s aqueous tablet-coating formulations must be capable of meeting these and other customer requirements in different application environments around the world using
Pancreatic cancer: why is it so hard to treat? (2013)

No common malignancy is as rapidly and inevitably fatal as pancreatic ductal adenocarcinoma (PDA). This grim fact has driven substantial research efforts into this disease in recent decades. Unfortunately, the investment has yet to result in a meaningful increase in 5-year survival. This has prompted many pancreatic cancer researchers and advocates to redouble their efforts, but also requires one to step back and ask why the previous efforts were lacking and to consider why pancreatic cancer is so difficult to treat. The difficulties are legion. PDA is characterized by an insidious clinical syndrome, but is rarely diagnosed at a time when surgical resection is feasible. We lack markers of early detection and screening programs remain unproven even in high risk populations. The location of the tumor in the retroperitoneum, the advanced age of patients, and the systemic effects of disease limit the options for local therapy. Chemotherapy may provide a small benefit, but most efforts to improve on the current regimens consistently and stubbornly fail in advanced clinical trials. The molecular and cellular features of ductal pancreatic tumors are aggressive and underlay multiple levels of therapeutic resistance. Non-cell-autonomous features including stromal proliferation, reduced vascular density and immune suppression also contribute to therapeutic resistance. Growing awareness of these the fundamental features of PDA has begun to guide ongoing research efforts. Clinical trials are now specifically targeting these tumor properties and actively focusing on the therapeutic implications of tumor stroma. As reviewed here, reflecting on the fundamental question of why pancreatic cancer is so difficult to treat is a necessary and informative exercise that will aid our efforts to improve patient outcomes. These efforts will lead to improvements in clinical trial design, expand our focus to include the molecular and histologic implications of novel treatment paradigms, and ultimately change the lives of our patients.
Schistosoma mansoniproteins attenuate gastrointestinal motility disturbances during experimental colitis in mice (2010)

Treatment with S. mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.
Thermal Decomposition of Tetrakis(ethylmethylamido) Titanium for Chemical Vapor Deposition of Titanium Nitride (2006)

The thermal decomposition of tetrakis(ethylmethylamido) titanium (TEMAT) has been investigated in Ar and <TEX>$H_2$</TEX> gas atmospheres at gas temperatures of 100-400 <TEX>${^{\circ}C}$</TEX> by using Fourier Transform infrared spectroscopy (FTIR) as a fundamental study for the chemical vapor deposition (CVD) of titanium nitride (TiN) thin film. The activation energy for the decomposition of TEMAT was estimated to be 10.92 kcal/mol and the reaction order was determined to be the first order. The decomposition behavior of TEMAT was affected by ambient gases. TEMAT was decomposed into the intermediate forms of imine (C=N) compounds in Ar and <TEX>$H_2$</TEX> atmosphere, but additional nitrile (RC<TEX>$\equiv$</TEX>N) compound was observed only in <TEX>$H_2$</TEX> atmosphere. The decomposition rate of TEMAT under <TEX>$H_2$</TEX> atmosphere was slower than that in Ar atmosphere, which resulted in the extension of the regime of the surface reaction control in the CVD TiN process.
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination (2012)

These results identify CSPGs as a nonpermissive substrate for OPCs and oligodendrocytes, and as a prominent impediment to remyelination. The data suggest the requirement for the neutralization of CSPGs for repair after demyelination.
Prediction of Breast Tumor Progression by Integrity of Free Circulating DNA in Serum (2006)

Integrity of serum circulating DNA is a promising molecular biomarker for detecting breast cancer tumor progression and regional LN metastases.
Keloid and Hypertrophic Scars: Comparative Histopathological and Immunohistochemical Study (2010)

Keloids and hypertrophic scars are different expressions of the same derailment of wound healing; their biological behaviors and appearances are quite different. The clinical differences between hypertrophic scars and keloids have long been recognized. However, distinguishing between the two types of scars on histology is sometimes difficult as the ‘keloid collagen’, the hallmark of keloid, is not always present. Plus the α-smooth muscle actins, a differentiating marker of hypertrophic scar is variably expressed in both forms of scars. The present study is an attempt to reinforce the validity of existing criteria and to investigate additional distinguishing features to facilitate the distinction between these two entities. The morphological features and the expression of α-smooth muscle actins in myofibroblasts in the two conditions have been investigated. These results demonstrate that keloids are characterized by the presence of collagen fibers, which are abnormally large, dense, broad, glassy, eosinophilic, focally fragmented complexes, arranged haphazardly and packed together by “keloid collagen”. In contrast hypertrophic scars exhibit collagen, which is discretely nodular, fibrillar with fairly regular thickness of fibers with its long axis parallel to the epidermis. It was confirmed that such nodular structures are always present in hypertrophic scar and rarely in keloid. Furthermore, keloid scars occasionally show myofibroblasts expressing α-smooth muscle actins, while hypertrophic scars are negative for α-smooth muscle actins
WINTER ROAD MAINTENANCE DECISION SUPPORT SYSTEM PROJECT: OVERVIEW AND STATUS (2004)

For several years, the U.S. Federal Highway Administration (FHWA) Office of Transportation Operations Road Weather Management Program has been involved in the development of a guidance tool for winter road maintenance decision makers. The tool, known as the maintenance decision support system (MDSS), is the culmination of work by a consortium of national laboratories, directed by FHWA with feedback from both the state departments of transportation and the private sector. The MDSS combines advanced weather and road condition prediction with automated rules of practice to produce a customized and optimized set of treatment recommendations for winter road maintenance managers. The potential payoff is higher mobility and safety on roadways, and more efficient and cost-effective use of staff, equipment, and chemicals. The latter would produce a reduced impact on the environment. This paper describes the history, development, and status of the MDSS project. Preliminary results and lessons learned from a field demonstration, future development efforts, and the technology transfer plan is discussed.
Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants (2016)

Ruminants have the remarkable ability to convert human-indigestible plant biomass into human-digestible food products, due to a complex microbiome residing in the rumen compartment of their upper digestive tract. Here we report the discovery that rumen microbiome components are tightly linked to cows' ability to extract energy from their feed, termed feed efficiency. Feed efficiency was measured in 146 milking cows and analyses of the taxonomic composition, gene content, microbial activity and metabolomic composition was performed on the rumen microbiomes from the 78 most extreme animals. Lower richness of microbiome gene content and taxa was tightly linked to higher feed efficiency. Microbiome genes and species accurately predicted the animals' feed efficiency phenotype. Specific enrichment of microbes and metabolic pathways in each of these microbiome groups resulted in better energy and carbon channeling to the animal, while lowering methane emissions to the atmosphere. This ecological and mechanistic understanding of the rumen microbiome could lead to an increase in available food resources and environmentally friendly livestock agriculture.
Expression and bioactivity of a human single-chain Fv antibody against the HBsAg (2002)

Objective:To produce human anti-HBsAg scFv which has activity of HBsAg binding.Methods:The V H and V L gene,amplified from the vector including human Fab fragment against HBsAg which was acquired by phage display,were linked together by(Gly 4Ser) 3 as a single-chain Fv antibody,which was then inserted into the vector pQE-40 and expressed as inclusion body in E.coli M15.Results:The optimal condition of induction was found to induce the culture of recombinant at 0.6 OD 600 for 6 hours.Under this experiment condition,the target protein amounted 31% of the total protein,reaching its highest production.The lysed inclusion body was purified by Ni 2+ charged column and the target protein was refolded by dialysis,so obtained the r-scFv to a purity of 97% with the bioactivity of HBsAg binding.The affinity constant of the refolded scFv was confirmed by non-competed ELISA to be 0.23×108 mol/L.Conclusion:The stable and efficient expression of scFv in M15-pQE40 can produce scFv antibody against HBsAg and this antibody could be the foundation for further clinic research.
Detection of Organ-Confined Prostate Cancer Is Increased Through Prostate-Specific Antigen—Based Screening (1993)

Screening based on PSA identifies some men with prostate cancer who have a significantly increased proportion of organ-confined tumors compared with those detected through evaluation for an abnormal DRE alone.
On the Justification of Complex Nonconsummate Offences (2007)

In zahlreichen Beiträgen werden alte und neue Fragen aus dem Bereich der Strafrechtsdogmatik analysiert und interpretiert. Einige Beiträge gehören in das weite Feld der Rechtsphilosophie und der juristischen Hermeneutik-Themen, denen sich Heike Jung in den letzten Jahren seines schaffensreichen akademischen Arbeitslebens immer stärker gewidmet hat. Gegenstand der meisten Abhandlungen sind jedoch Heike Jungs Aufsätze zur Theorie und Praxis des Strafprozesses, der Kriminologie und des Sanktionssystems. Den Strafprozess durch Diskurselemente anzureichern, in der Kriminologie die hermeneutische Dimension nicht zu vergessen und das Resozialisierungsprinzip, kontrafaktisch, zu postulieren, das ist Heike Jungs ceterum censeo – und diese Dimensionen werden in den Aufsätzen renommierter Autoren kongenial untersucht.
Post-transcriptional regulation of chloramphenicol acetyl transferase (1984)

The +1 site for initiation of inducible chloramphenicol acetyl transferase (CAT) mRNA encoded by plasmid pC194 was determined experimentally by using [alpha-32P]ATP-labeled runoff transcripts partially digested with T1 RNase. By partial digestion of the in vitro transcripts with S1, T1, and cobra venom nucleases as probes of mRNA conformation, single- and double-stranded regions, respectively, were also identified. Thus, a prominent inverted complementary repeat sequence was demonstrated spanning the +14 to +50 positions, which contain the complementary sequences CCUCC and GGAGG (the Shine and Dalgarno sequence for synthesis of CAT) symmetrically apposed and paired as part of a perfect 12-base-pair inverted complementary repeat sequence (-19.5 kcal [ca. -81.7 kJ] per mol). The CAT mRNA was stable to digestion by T1 RNase at the four guanosine residues in the Shine and Dalgarno sequence GGAGG , even at 60 degrees C, suggesting that nascent CAT mRNA allows ribosomes to initiate protein synthesis inefficiently and that induction involves post-transcriptional unmasking of the Shine and Dalgarno sequence. Consistent with this model of regulation, we found that cells carrying pC194 , induced with chloramphenicol, contain about the same concentration of pulse-labeled CAT-specific RNA as do uninduced cells. Induction of CAT synthesis by the non- acetylatable chloramphenicol analog fluorothiamphenicol was tested by using minicells of Bacillus subtilis carrying pC194 as well as minicells containing the cloned pC194 derivatives in which parts of the CAT structural gene were deleted in vitro with BAL 31 exonuclease. Optimal induction of both full-length (active) and deleted (inactive) CAT required similar concentrations of fluorothiamphenicol, whereas induction by chloramphenicol required a higher concentration for the wild-type full-length (active) CAT than for the (inactive) deleted CAT. Because synthesis of deleted CAT was inducible, we infer that CAT plays no direct role in regulating its own synthesis.
Imaging the Internal Structure of the Rat Cochlea Using Optical Coherence Tomography at 0.827 μm and 1.3 μm (2004)

These images reflect the ability of OCT to provide images of the internal cochlea structure with micron scale resolution and at near-real time frame rates.