gebhart/patrepeval huggingface dataset:
Topological superconductivity and Majorana fermions in metallic surface states (2012)

Heavy metals, such as Au, Ag, and Pb, often have sharp surface states that are split by strong Rashba spin-orbit coupling. The strong spin-orbit coupling and two-dimensional nature of these surface states make them ideal platforms for realizing topological superconductivity and Majorana fermions. In this paper we further develop a proposal to realize Majorana fermions at the ends of quasi-one-dimensional metallic wires. We show how superconductivity can be induced on the metallic surface states by a combination of proximity effect, disorder, and interactions. Applying a magnetic field along the wire can drive the wire into a topologically nontrivial state with Majorana end states. Unlike the case of a perpendicular field, where the chemical potential must be fine-tuned near the Rashba band crossing, the parallel field allows one to realize Majorana fermions for an arbitrarily large chemical potential. We then show that, despite the presence of a large carrier density from the bulk metal, it is still possible to effectively control the chemical potential of the surface states by gating. The simplest version of our proposal, which involves only an Au(111) film deposited on a conventional superconductor, should be readily realizable.
HOXandNon‐HOXHomeobox Genes in Leukemic Hematopoiesis (2002)

Dysregulation of homeobox (HB)-containing genes is becoming increasingly recognized as the underlying basis of many hematologic malignancies. Expression of clustered HB (HOX) genes within the hematopoietic system, and enforced overexpression and knockout studies have provided support for the concept that these homeodomain-containing transcription factors play a significant role in the developmental biology of hematopoietic cells. Diverged HB (non-HOX) genes have recently been identified as either cofactors and/or accelerators of leukemic disease mediated by HOX genes or as bona fide oncogenes. In this review, we examine the evidence that supports a central role for HB genes in normal and malignant hematopoiesis, paying particular attention to the non-HOX class and the possible mechanisms through which they contribute to leukemic transformation.
Introduction to Random Processes (1986)

Introduction to random processes , Introduction to random processes , کتابخانه دیجیتال جندی شاپور اهواز
Cockroach allergen (Bla g 1) in school dust (1997)

We conclude that Bla g 1 is detectable at potentially significant concentrations in some inner city schools. Furthermore, the level of exposure is different between different schools and between sites within individual schools.
Combination pharmacotherapy for neuropathic pain: current evidence and future directions (2005)

Current drugs reduce neuropathic pain and improve mood and quality of life. However, as single agents they are limited by incomplete efficacy and dose-limiting adverse effects. Recent experimental and clinical data support the potential of combination pharmacotherapy for neuropathic pain. Therapeutic benefits may include greater efficacy, lower doses and fewer adverse effects. Due to potential adverse, as well as beneficial, drug interactions, safety and efficacy of specific combinations must be empirically evaluated. Techniques such as isobolographic analysis, response-surface modeling and other model-free tests have been used in order to characterize analgesic interactions as antagonistic, additive or synergistic. Whether synergistic or not, a clinically useful combination could simply have additive or even subadditive analgesia, provided that there is less additivity for side effects. Despite widespread clinical use, there are surprisingly few published observations on combination therapy for neuropathic pain. This review discusses future directions and proposes research strategies aimed at bridging current knowledge gaps, including safety, compliance and cost–effectiveness; discovering optimal drug combinations and dose ratios; comparing concurrent with sequential combination therapy; and combining more than two drugs. Continued close integration of basic and clinical sciences is crucial in further harnessing the potential of combination pharmacotherapy in neuropathic pain.
The Carboxylation of Active Methylene Compounds with Diphenylcarbodiimide and Potassium Carbonate (1990)

Abstract Active methylene compounds were carboxylated by employing the reagent system, diphenylcarbodiimide and potassium carbonate, in dimethyl sulfoxide at room temperature and atmospheric pressure. The reaction proceeded even in the absence of carbon dioxide, but the carboxylation easily proceeded in carbon dioxide atmosphere.
Catheter with an anchoring tip for chronic joint capsule perfusion. (1992)

An orthopedic catheter for long-term access to the synovial joint is anchored by a hollow threaded tap that penetrates the capsule through a hole drilled in the surrounding bone. The proximal end of the catheter is connected to either an implantable drug infusion pump or an implantable access port for continuous or intermittent perfusion or sampling. Four catheters were evaluated in dogs. Three were attached to ports, the fourth to a pump. Water (one trial, 22 weeks) and hyaluronic acid (HA) (5 mg/ml; two trials of 8 weeks each) were administered through ports twice weekly in 1.5 ml boluses; 5 mg/ml HA was delivered by pump (1 trial of 33 weeks) at 0.31 ml/day.
Ultralow-Noise Packaged 1.55-µm Semiconductor External-Cavity Laser with 0.37-W Output Power (2009)

We demonstrate a semiconductor external-cavity laser comprising a slab-coupled optical waveguide amplifier (SCOWA) and a fiber Bragg grating. The laser exhibits a Lorentzian linewidth of 1.75 kHz and a sidemode suppression ratio &gt; 80 dB.
In Vivo Robotic Laparoscopy (2005)

Laparoscopy reduces patient trauma but limits the surgeon's ability to view or touch the surgical environment directly. The surgeon's ability to visualize and manipulate target organs can be improved using currently available external robotic systems. However, tool tip orientation and optimal camera placement remain limited because the robot instruments and cameras are still constrained by the entry incisions. Placing a robot completely within the abdominal cavity would provide an unconstrained platform that could provide an enhanced field of view from arbitrary angles and dexterous manipulators not constrained by the abdominal wall fulcrum effect. Several in vivo robots have been developed and successfully tested in a porcine model. These in vivo robots have been used to observe trocar and tool insertions and placement, and to provide additional camera angles that improved surgical visualization. Equipped with a grasper, such robots will provide task assistance. These in vivo robots will be much less expensive than the current generation of large external robotic surgical systems and will ultimately allow a surgeon to be a remote first responder irrespective of the location of the patient.
Modulation of endothelial cell functions by different molecular species of interleukin 1 (1987)

Different molecular species of interleukin 1 (IL 1) were examined for the spectrum of responses elicited in human endothelial cells (HEC), including synthesis of prostacyclin (PGI2), tissue-type procoagulant activity (PCA), platelet activating factor (PAF), and plasminogen activator inhibitor (PA-I). The IL 1 preparations utilized for the present study included a natural, partially purified IL 1, a preparation purified to homogeneity with extensive homology with the derived aminoacid IL 1 beta (pI7) sequence denominated “22K factor,” murine recombinant IL 1 alpha, human recombinant IL 1 alpha (pI5) and beta (pI7). Natural, partially purified IL 1, a mixture of alpha and beta species, induced the entire spectrum of responses in HEC. Production of PA-I was elicited by all forms of IL 1 tested. PGI2 and PCA were elicited by “22K factor” and by human recombinant IL 1 beta and alpha but not by murine recombinant IL 1 alpha. PAF synthesis was stimulated by murine and human recombinant IL 1 alpha but not by human recombinant IL 1 beta and 22K factor. Thus the available different molecular forms of IL 1 elicit largely but not completely overlapping patterns of responses in HEC. The IL 1 pathway of regulation of HEC functions might provide a basis for novel strategies in therapeutically oriented research on vessel wall disorders.
Toward a Molecular Basis of Alcohol Use and Abuse (1994)

The 39 chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent informat
Electrical Properties Tomography in the Human Brain at 1.5, 3, and 7T: A Comparison Study (2013)

The transceive phase assumption is most accurate for low-field strengths and low permittivity and in symmetric objects. The phase-only conductivity reconstruction is only applicable at 1.5 and 3T for the investigated geometries. The measurement precision was found to benefit from a higher field strength, which is related to increased signal-to-noise ratio (SNR) and increased curvature of the B1 (+) field.
Male and Female Athletes' and Nonathletes' Expectations about Sport Psychology Consulting (2001)

Abstract The purpose of this study was to explore expectations of athletes and nonathletes about sport psychology consulting. Tinsley's (1982) Expectations About Coun-seling-Brief form was revised using sport psychology terms. The revised instrument, Expectations About Sport Psychology Consulting (EASPC) questionnaire, was administered to 111 athletes (64 male and 47 female) and 166 nonathletes (72 male and 94 female) attending an NCAA Division I university. Confirmatory factor analysis showed that the data fit the hypothesized 3-factor model (i.e., personal commitment, facilitative conditions, and consultant expertise). A 2 (College Sport Participation) 2 (Gender) MANOVA and follow-up discriminant function analyses revealed that females had higher expectancies of personal commitment than did males whereas males believed that consultants were more directive and more capable of solving problems quickly than did females. No significant differences were obtained between athletes and their peers. The results indicate that the EASPC instrument might be a valuable tool for determining expectations about sport psychology consulting.
The TickerTAIP parallel RAID architecture (1993)

Traditional disk arrays have a centralized architecture, with a single controller through which all requests flow. Such a controller is a single point of failure, and its performance limits the maximum size that the array can grow to. We describe here TickerTAIP, a parallel architecture for disk arrays that distributed the controller functions across several loosely-coupled processors. The result is better scalability, fault tolerance, and flexibility.
Pharmacological characterization of the chemokine receptor, CCR5 (2002)

1. We investigated the effects of a number of naturally occurring chemokines (MIP-1alpha, MIP-1beta, RANTES, MCP-2, MCP-3, MCP-4) on different processes linked to the chemokine receptor CCR5 in recombinant CHO cells expressing the receptor at different levels. 2. Internalization of CCR5 following chemokine treatment was studied and MIP-1alpha, MIP-1beta and RANTES (50 nM) were able to induce internalization (similar50%) of the receptor. Internalization due to MCP-2, MCP-3 and MCP-4 was less (similar20%). 3. Phosphorylation of CCR5 following chemokine treatment was studied and MIP-1alpha, MIP-1beta and RANTES (50 nM) were able to induce phosphorylation of CCR5 whereas the other chemokines did not induce CCR5 phosphorylation. 4. MIP-1alpha, MIP-1beta, RANTES and MCP-2 were able to stimulate [(35)S]-GTPgammaS binding, an index of receptor/G protein activation, whereas MCP-3 and MCP-4 had no effect in this assay. MCP-2 was a partial agonist (similar80%) compared to MIP-1alpha, MIP-1beta and RANTES, which gave similar maximal stimulations in this assay. 5. MIP-1alpha, MIP-1beta, RANTES, MCP-2 and MCP-4 were able to stimulate increases in intracellular calcium ions via activation of CCR5 whereas MCP-3 was without effect. 6. It is concluded that different chemokines interacting with CCR5 mediate different patterns of cellular responses.
[Substances with antiviral activity. XIII. Synthesis and in vitro activity of thiosemicarbazones of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindoles]. (1980)

A series of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindole thiosemicarbazones was synthesized and investigated for antiviral activity against vaccinia virus IHD strain and parainfluenza virus type 3, HA-I/CR-8 strain. The results confirmed the previously observed high activity against vaccinia virus of m-substituted benzoyl derivatives. On the contrary, the analogous benzyl derivatives showed marginal activity; the compound (V c), however, was the most active against the parainfluenza virus.
A full-color SXGA TN AMLCD for military head-mounted displays and viewer applications (2008)

We report progress in developing a 0.97-in diagonal AMLCD with a full color SXGA resolution. A 1280&times;1024&times;3 dot array was developed with integrated color pixel filters to create an SXGA color pixel array. These displays are fabricated on 8-inch SOI wafers and transferred to glass wafers to produce transmissive liquid crystal displays. Improvements have been made in this AMLCD to bring the fabrication process to manufacturing. Fabricating a 3.9 million pixel dot display on a 1-inch die required a new display design and fabrication in an 8-inch wafer line. The 8-inch process provided enhanced process capabilities and tighter design rules to achieve good performance and reasonable starting yields. An ASIC driver and ultra thin efficient backlight were developed to miniaturize the display module and to reduce total power to < 750mW for soldier mounted applications. Total package size is less than 0.5 in<sup>3</sup>. The ASIC will also drive Kopin SVGA and VGA color displays singly or in pairs for binocular applications. An end-to-end 8-inch wafer process was established at the wafer foundry and at Kopin. A 3-year manufacturing technology insertion program (Mantech) has begun to optimize the 8-inch line processes and the SXGA color display. Meeting yield and performance goals will reduce display cost and enable systems performance goals. Key results include vivid, high-resolution color, wide viewing angles and low power operation. Performance data and specifications will be presented.
MBNL1 Is the Primary Determinant of Focus Formation and Aberrant Insulin Receptor Splicing in DM1 (2004)

In myotonic dystrophy 1 (DM1), aggregation of the mutant DMPK RNA into RNA-protein complexes containing MBNL1 and MBNL2 has been linked to aberrant splicing of the insulin receptor (IR) RNA. In a parallel line of investigation, elevated levels of CUG-binding protein (CUG-BP) have been shown to result in altered IR splicing in DM1. The relative importance of MBNL1, MBNL2, and CUG-BP in DM1 pathogenesis is, however, unclear. Here we have demonstrated that either small interfering RNA-mediated down-regulation of MBNL1 and MBNL2 or the overexpression of CUG-BP in normal myoblasts results in abnormal IR splicing. Our results suggest that CUG-BP regulates the equilibrium of splice site selection by antagonizing the facilitatory activity of MBNL1 and MBNL2 on IR exon 11 splicing in a dose-dependent manner. We have shown that CUG-BP levels are elevated in DM1 cells by mechanisms that are independent of MBNL1 and MBNL2 loss. Importantly, rescue experiments in DM1 myoblasts demonstrated that loss of MBNL1 function is the key event, whereas the overexpression of CUG-BP plays a secondary role in the aberrant alternative splicing of IR RNA in DM1. Small interfering RNA-mediated down-regulation of MBNL1, MBNL2, and CUG-BP in DM1 myoblasts demonstrated that MBNL1 plays a critical role in the maintenance of DM1 focus integrity. Thus, these experiments demonstrate that sequestration of MBNL1 by the expanded CUG repeats is the primary determinant of both DM1 focus formation and the abnormal splicing of the IR RNA in DM1 myoblasts. The data therefore support MBNL1-mediated therapy for DM1.
Long-Term Health and Predictors of Survival for Hyperthyroid Cats Treated with Iodine 131 (2001)

Abstract Two hundred thirty-one cats treated with radioactive iodine at the Texas Veterinary Medical Teaching Hospital were followed for a median of 25 months by means of an ambidirectional (prospective, retrospective) cohort study design. Cox proportional hazards models were used to determine predictors of survival based on data at the time of hyperthyroid diagnosis (collected retrospectively) and found that only age at diagnosis and sex of the cat were predictors of survival. Increasing age (for each year of age, relative risk [RR] = 1.2, 95% confidence interval [CI] = 1.1–1.3) and being male (RR = 0.68, 95% CI = 0.5–0.9) increased likelihood of death. Tables predicting survival after diagnosis and treatment of hyperthyroidism for various age and sex combinations were created. In addition, Cox proportional hazard models were run with all data available at the end of the study (collected retrospectively and prospectively) including number and type of major health problems reported at the time of death or censoring. In this model, significant factors were age at diagnosis, sex, and either type of major health problem or number of health problems. Cats with renal disease or cancer were more likely not to survive and increasing from none to 2 health problems also decreased survival. Renal problems and cancer were the most common health problems at the time of death or censoring. This study provides estimates of duration of survival for cats successfully treated for hyperthyroidism with radioactive iodine, which can be useful in assisting with client treatment decisions.
Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation. (1988)

The iC3b receptor (CR3) is required for neutrophil adhesive functions, including homotypic aggregation. Because stimuli that enhance neutrophil adhesion also induce up-regulation of surface CR3, it is widely held that these two responses are causally related. We have dissociated CR3 display (immunofluorescence) from CR3 function (aggregation). Neutrophils isolated at 4 degrees C and rewarmed to 37 degrees C up-regulated surface CR3 twofold, but did not aggregate. The kinetics of FMLP-induced CR3 up-regulation were discordant with those of aggregation. In the absence of extracellular divalent cations, CR3 expression increased twofold after exposure to FMLP, but neutrophils did not aggregate. FMLP elicited 3.5-fold more aggregation than the ionophore A23187, yet less than one-half as much CR3 up-regulation. 3 mM sodium salicylate inhibited aggregation 55 +/- 4%, but had no effect on CR3 up-regulation. Conversely, 1 mM tetracaine completely inhibited CR3 up-regulation, while significantly enhancing aggregation. Neutroplasts expressed CR3, but did not up-regulate the receptor; in contrast, FMLP induced CR3-dependent aggregation of neutroplasts. We conclude that, although constitutive surface CR3 is required for neutrophil aggregation, the up-regulation of CR3 is neither necessary nor sufficient to promote cell-cell adhesion.
Sugar Effects on Murine Sarcoma Virus Transformation (1973)

Transformation of NIH Swiss mouse fibroblasts by a murine sarcoma virus was influenced by the type of carbohydrate in the culture medium. Exposure to D-mannose and 2-deoxy-D-glucose caused a reduction in the number of transformed colonies in vitro and tumor formation in vivo. This is a new type of interference in the transformation process, manifested also by the absence of the pronounced enhancement of hexose entry into transformed cells, characteristic of a sarcoma virus infection. The uptake of D-glucose, D-mannose, and D-galactose, was repressed by normal mouse cells grown in the presence of D-mannose and D-glucose in the medium, while uptake of the same sugars was derepressed in cells grown in media containing D-xylose, L-xylose, or L-arabinose. D-Galactose had an intermediate effect on hexose uptake and permitted derepression. In every case, enhancement of the primary transport by sarcoma virus transformation was consistently beyond that observed at any time in the derepressed control cells, demonstrating the occurrence of another mechanism of enhancement of hexose uptake after sarcoma virus infection.
Sexually Transmitted Infections Among US Women and Men (2013)

Sexually transmitted infections are common in the United States, with a disproportionate burden among young adolescents and adults. Public health efforts to address STIs should focus on prevention among at-risk populations to reduce the number and impact of STIs.
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION (1959)

Lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials. The entire procedure can be carried out in approximately 10 minutes; it is efficient, reproducible, and free from deleterious manipulations. The wet tissue is homogenized with a mixture of chloroform and methanol in such proportions that a miscible system is formed with the water in the tissue. Dilution with chloroform and water separates the homogenate into two layers, the chloroform layer containing all the lipids and the methanolic layer containing all the non-lipids. A purified lipid extract is obtained merely by isolating the chloroform layer. The method has been applied to fish muscle and may easily be adapted to use with other tissues.