gebhart/patrepeval huggingface dataset:
A Terahertz Chemical Microscope to Visualize Chemical Concentrations in Microfluidic Chips (2007)

Here, a new type of terahertz chemical microscope (TCM) is proposed and developed, and the first demonstration of imaging the chemical concentration in fluid channels is reported. Fluid samples flow through channels possessing a semiconductor sensing plate as a bottom wall. Terahertz (THz) waves are radiated from the sensing plate as a result of femtosecond laser illumination. Because the amplitude of the THz radiation depends on the concentration of ions adsorbed on the surface of the plate, the ion distribution in the fluid channels can be visualized by scanning the laser across the plate. An image showing separated solutions with two different proton concentrations is successfully observed as the first demonstration of this instrument.
Polythiolesters (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolythiolestersC. S. Marvel and Alex KotchCite this: J. Am. Chem. Soc. 1951, 73, 3, 1100–1102Publication Date (Print):March 1, 1951Publication History Published online1 May 2002Published inissue 1 March 1951https://pubs.acs.org/doi/10.1021/ja01147a063https://doi.org/10.1021/ja01147a063research-articleACS PublicationsRequest reuse permissionsArticle Views319Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Consistent inexact graph matching applied to labelling coronary segments in arteriograms (2003)

As part of the development directed at the automated reporting of the location and degree of stenoses in a coronary arterial tree, the authors address the issue of automated labelling of coronary segments. With a priori information of the coronary anatomy related to the projection geometry, the branches of a coronary tree are labelled by a consistent inexact graph matching (CIGM) technique. They describe the CIGM technique, the cost functions and associated parameters, a representation of the segments of the arterial tree and their experience in labelling arteries in routinely acquired arteriograms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: MULTIPLE METAL‐CARBON BONDS. 6. THE REACTION OF NIOBIUM AND TANTALUM NEOPENTYLIDENE COMPLEXES WITH SIMPLE OLEFINS‐ A ROUTE TO METALLOCYCLOPENTANES (1977)

Abstract Die nucleophilen Titelverbindungen (II), die aus den Komplexen (I) dargestellt wurden, reagieren mit Olefinen wie Äthylen zu neuen Olefinen wie (III) durch Umlagerung intermediär gebildeter Metallocyclobutane.
Failure of Estrogen Plus Progestin Therapy for Prevention (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Providing Fine-Grained Access Control for Mobile Programs Through Binary Editing (1998)

Abstract : With the advent of WWW, there is considerable interest in programs that can migrate from one host to another and execute. For instance, Java programs are increasingly being used to add dynamic content to a web page. When a user accesses the web page through a browser, the browser migrates the Java program and executes it at the user's site. Mobile programs are appealing because they support efficient utilization of network resources and extensibility of information servers. However, since they cross administrative domains, they have the ability to access a host site's protected resources. For instance, they can potentially read a user's private files, access and modify personal information, and steal proprietary information. In this paper, we present a novel approach for allowing a site to protect and control the local resources that external Java programs can access. In this approach, a site uses a declarative policy language to specify a set of constraints on accesses to local resources and the conditions under which they apply. A set of code transformation tools enforce these constraints on a Java program by integrating the code for checking access constraints into the program and the site's resource definitions. Executions of the resulting modified mobile program and resources satisfy all access constraints, thereby protecting the site's resources. Because this approach does not require resources to make an explicit call to a reference monitor, as implemented in the Java runtime system, the approach does not depend upon a particular runtime system implementation.
Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet. (1995)

High levels of CD36 expression are found in triglyceride storing and secreting cells such as differentiated adipocytes and mammary secretory epithelial cells and in some capillary endothelial cells. We have found high levels of CD36 in the capillary endothelium of murine adipose tissue and in cardiac and skeletal muscles. Muscle cells themselves were CD36 negative. No CD36 was found in brain endothelium. Cardiac and skeletal muscle tissues are highly oxidative and catabolize long-chain fatty acids as a source of energy while brain tissue does not use long-chain fatty acids for energy production. Since capillary endothelial cell CD36 expression appeared to correlate with parenchymal cell fatty acid utilization and since CD26 has been identified recently as a long-chain fatty acid-binding protein, we examined heart tissue CD36 expression in murine models of insulin-dependent (nonobese diabetic, NOD) and non-insulin-dependent diabetes mellitus (KKAY). Diabetic NOD and KKAY mice had serum triglyceride levels 2.6- and 4.2-fold higher, respectively, than normal mice and exhibited 7- and 3.5-fold higher levels of heart microsomal CD36, respectively, than control mice. Mice fed a 40% fat diet expressed heart tissue CD36 at a level 3.5-fold higher than those fed a 9% fat diet. These data suggest that endothelial cell CD36 expression is related to parenchymal cell lipid metabolism.
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity (2008)

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown. In this study, we show that leptin, which instead inhibits insulin secretion, partly uses the sympathetic nervous system to fulfill this function. Remarkably, for our purpose, an osteoblast-specific ablation of sympathetic signaling results in a leptin-dependent hyperinsulinemia. In osteoblasts, sympathetic tone stimulates expression of Esp, a gene inhibiting the activity of osteocalcin, which is an insulin secretagogue. Accordingly, Esp inactivation doubles hyperinsulinemia and delays glucose intolerance in ob/ob mice, whereas Osteocalcin inactivation halves their hyperinsulinemia. By showing that leptin inhibits insulin secretion by decreasing osteocalcin bioactivity, this study illustrates the importance of the relationship existing between fat and skeleton for the regulation of glucose homeostasis.
The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion (2005)

Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, we derived a conditional knockout of HNF-4α using the Cre-loxP system. Surprisingly, deletion of HNF-4α in β cells resulted in hyperinsulinemia in fasted and fed mice but paradoxically also in impaired glucose tolerance. Islet perifusion and calcium-imaging studies showed abnormal responses of the mutant β cells to stimulation by glucose and sulfonylureas. These phenotypes can be explained in part by a 60% reduction in expression of the potassium channel subunit Kir6.2. We demonstrate using cotransfection assays that the Kir6.2 gene is a transcriptional target of HNF-4α. Our data provide genetic evidence that HNF-4α is required in the pancreatic β cell for regulation of the pathway of insulin secretion dependent on the ATP-dependent potassium channel.
Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium-Catalyzed Cross-Coupling Reactions of Organoboron CompoundsNorio. Miyaura and Akira. SuzukiCite this: Chem. Rev. 1995, 95, 7, 2457–2483Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/cr00039a007https://doi.org/10.1021/cr00039a007research-articleACS PublicationsRequest reuse permissionsArticle Views90442Altmetric-Citations11246LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Skeletal Muscles of Ambulant Children with Duchenne Muscular Dystrophy: Validation of Multicenter Study of Evaluation with MR Imaging and MR Spectroscopy (2013)

The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.
Romania and NATO: The time for a real partnership (1997)

Romania, after many years of Communist rule, returned to democratic rule, last November, As a result, His Majesty King Michael of Romania was allowed back to his native country for the first time since 1947. In this speech His Majesty explains Romania's position on NATO membership, making the case that Romania is now ready to become a member of the North Atlantic Organisation; it is now a democratic country with a government firmly in control of the military forces and a people of whom, 90 per cent favours NATO membership. Participation in NATO is a necessity not only for the stability of Romania and its neighbours but for the security of the whole of Europe. While there is broad backing for Romanian membership of NATO in large parts of Europe, King Michael appeals to Britain to join the group of supporting countries.
Separation and Characterization of Toxic and Nontoxic Forms of Lipid A (1984)

Highly purified and well-characterized samples of precursors and derivatives of bacterial lipopolysaccharides (LPS) were used to study the relationship between the chemical structure of lipid A and its toxicity. These samples included lipids X and Y (monosaccharide precursors of lipid A) from Escherchia coli MN7; incomplete lipid A (a disaccharide precursor of lipid A) from Salmonella typhimurium i50; and monophosphoryl lipid A, TLC-3 (a derivative of LPS), from S. typhimurium G30/C21. In addition, a diphosphoryl lipid A, TLC-3, was prepared from LPS of S. typhimurium G30/C21 and characterized by positive fast atom bombardment mass spectrometry. The diphosphoryl lipid A, TLC-3 fraction, was determined to be very toxic by the chick embryo lethal-dose test (CELD50 = 0.0064 microgram). Lipids X and Y, incomplete lipid A, and monophosphoryl lipid A (TLC-3), were all nontoxic (CELD50 greater than 10 micrograms). These results suggest a multiple structural requirement for toxicity of lipid A. Toxic lipid A must contain all of the following components: a glucosamine disaccharide, a sugar-1-phosphate, and normal fatty acid(s).
Activation of platelet heparitinase by vascular cell lysates. (1995)

Tumour cells have been reported to contain an activator of platelet heparitinase which is absent from normal cells. Using an assay which measures the degradation of radiolabelled heparin, we observed that lysates of metastatic melanoma cells did activate platelet radiolabelled heparin, we observed that lysates of metastatic melanoma cells did activate platelet heparitinase but that lysates of arterial endothelial and smooth muscle cells did likewise, with the latter being particularly effective. The activator largely survived a 10 min preincubation of the cell lysates at 70 degrees C, but not at 100 degrees C. Experimental results indicated that the contents of 10(5) vascular smooth muscle cells could increase platelet heparitinase activity in vitro to 6 times its initial value. We suggest such activation may have physiological relevance and may even assist the development of certain cardiovascular diseases in man.
Late embryogenesis‐abundant genes encoding proteins with different numbers of hydrophilic repeats are regulated differentially by abscisic acid and osmotic stress (1992)

Summary The late embryogenesis‐abundant ( Lea ) genes, which are suggested to act as desiccation protectants during seed desiccation and in water‐stressed seedlings, can be induced by abscisic acid (ABA) and various kinds of water‐related stress. Using cotton Lea cDNAs as probes it was found that several of the Lea genes are conserved at the mRNA level in dicots and monocots. By screening a barley cDNA library with a cotton Lea D19 cDNA a family of three members was isolated. The putative B19 proteins have strong similarities to the Em protein in wheat and to LEA proteins from several dicots. However, the middle part of the B19 proteins consists of a 20‐amino acid motif repeated three and four times in B19.3 and B19.4, respectively, but only once in B19.1. The gene products are strongly hydrophilic, the internal 20‐amino acid motif being the most hydrophilic part. This motif is found once in cotton Lea D19 but is repeated twice in cotton Lea D132, indicating that the repeats are universal among monocot and dicot B19‐like genes. The B19 genes are regulated similarly during embryo development, but to very different levels. In contrast, they are differentially regulated by ABA and various types of osmotic stress. In immature embryos all three genes are responsive to ABA and mannitol. However, B19.1 is also responsive to salt. Cold stress does not induce B19 mRNAs; only a stabilization of the transcript levels is seen. These results suggest that the responses to salt stress and exogenous ABA operate through different pathways.
Feasibility study of VLSI device layer transfer by CMP PETEOS direct bonding (2002)

Reports here the first results of using plasma enhanced CVD TEOS (Si(C/sub 2/H/sub 5/O)/sub 4/) oxide (PETEOS) and associated CMP (Chemical Mechanical Polishing) technology to form a flat layer on the surface of a processed VLSI bulk Si wafer for direct bonding. The undoped PETEOS oxide has also been used as a bonding layer for substrates onto which the IC layer is to be transfered and whose surfaces are not favorable for bonding.
EVOLVING RIBOSOME STRUCTURE: DOMAINS IN ARCHAEBACTERIA, EUBACTERIA, EOCYTES AND EUKARYOTES (1985)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
The influence of polyaspartate additive on the growth and morphology of calcium carbonate crystals. (2021)

I would like to acknowledge several people who have been helpful throughout my graduate career.First, I feel veiy fortunate to have had the experience of working under the advisement of Dr. David Tirrell, and I am sui^I am not alone in that regard."It is nut o find an advisor who is both an
TANSLEY REVIEW NO. 5 FRUCTANS AND THE METABOLISM OF SUCROSE IN VASCULAR PLANTS (1986)

The occurrence, structure and metabolism of fructose polymers in tissues of vascular plants are discussed in relation to the metabolism of sucrose. Distinctions are made between long-term and short-term storage of such polymers and the regulatory mechanisms which govern accumulation are examined. The roles of various fructosyltransferases in the synthesis of the different fructan structures from sucrose are outlined. The potential selective advantages of the possession of fructan metabolism in different species are assessed with reference to possible roles as cryoprotectants, in osmotic control and as storage carbohydrates whose metabolism can continue at low temperatures (0 to 5°C). It is concluded that the complexity and variety of fructan structures and of the associated enzyme systems has resulted in an incomplete understanding of their physiology and biochemistry, but their significance as an alternative storage polysaccharide in both leaves and storage organs should not be underestimated. Contents I. Introduction II. The structure of fructans in vascular plants: variations on a theme 2 III. The enzymes of fructan synthesis: common elements and sources of structural diversity 5 IV. The comparative biology of fructan metabolism: diversity in occurrence and function 11 V. Concluding remarks 19 Acknowledgements 19 References 19.
Elevated Circulating Levels of Monocyte Chemoattractant Protein-1 in Patients With Restenosis After Coronary Angioplasty (2001)

Inflammation plays a pathogenic role in the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA). Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant of monocytes; however, its role in the pathophysiology of restenosis is still unclear. We set out to investigate the role of MCP-1 in restenosis after PTCA. In addition, we tested the hypothesis that MCP-1 exerts its effect, at least in part, by inducing O(2)(-) generation in circulating monocytes. Plasma levels of MCP-1 were measured before and 1, 5, 15, and 180 days after PTCA in 50 patients (30 males and 20 females, aged 62+/-5 years) who underwent PTCA and who had repeated angiograms at 6-month follow-up. Restenosis occurred in 14 (28%) patients. The MCP-1 level was no different at baseline between patients with or without restenosis. However, after the procedure, restenotic patients, compared with nonrestenotic patients, had statistically significant (P<0.0001) elevated levels of MCP-1. In contrast, plasma levels of other chemokines, such as RANTES and interleukin-8, did not differ between the 2 groups after PTCA. Higher MCP-1 throughout the study was correlated with restenosis. Moreover, increased MCP-1 was significantly correlated with increased monocyte activity, as reflected by enhanced O(2)(-) generation. Finally, multivariate regression analysis showed that the MCP-1 plasma level measured 15 days after PTCA was the only statistically significant independent predictor of restenosis (beta=0.688, P<0.0001). This study suggests that MCP-1 production and macrophage accumulation in the balloon-injured vessel may play a pivotal role in restenosis after PTCA. MCP-1 may induce luminal renarrowing, at least in part, by inducing O(2)(-) release in monocytes. Further understanding of the mechanism(s) by which MCP-1 is produced and acts after arterial injury may provide insight into therapies to limit the progression of atherosclerosis and restenosis after balloon angioplasty.
Blind Frequency-Offset Estimation for OFDM/OQAM Systems (2007)

This paper deals with the problem of blind carrier-frequency offset (CFO) estimation in orthogonal frequency-division multiplexing (OFDM) systems based on offset quadrature amplitude modulation (OFDM/OQAM). Specifically, by assuming that the number of subcarriers is sufficiently large, the received signal is modeled as a complex Gaussian random vector (CGRV). Since the OFDM/OQAM signal results to be a noncircular (NC) process (i.e., its relation function is different from zero), by exploiting the generalized probability density function for NC-CGRVs, the unconditional maximum-likelihood algorithm for CFO estimation in nondispersive channel is derived. Moreover, due to its computational complexity, a more feasible estimator is considered. The performance of the proposed estimators, assessed via computer simulation, is compared with that of recently proposed CFO estimators exploiting second-order cyclostationarity and with the Gaussian Crameacuter-Rao bound
Paracrine stimulation of keratinocytes in vitro and continuous delivery of epidermal growth factor to wounds in vivo by genetically modified fibroblasts transfected with a novel chimeric construct. (1997)

A single application of irradiated EGF genetransfected fibroblasts to wounds can thus continuously deliver the transgene in vivo and could be used to administer drugs to the wound bed during the crucial first seven days of wound-healing.
Inhibition of β-glucuronidase by natural glucuronides ofKampo, medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate (1993)

1. 7-Ethyl-10-[4-(piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11), a potent anticancer agent currently under development for clinical use, is metabolized in vivo to 7-ethyl-10-hydroxycamptothecin (SN-38), which is subsequently conjugated to 7-ethyl-10-hydroxycamptothecin glucuronide (SN-38-glucuronide). The SN-38-glucuronide was hydrolysed by beta-glucuronidase from E. coli to aglycones and glucuronic acid. 2. Four purified natural glucuronides including baicalin, wogonoside, luteolin-3'-glucuronide, and glycyrrhizin, inhibited beta-glucuronidase using SN-38-glucuronide as substrate. The inhibition potencies of these natural glucuronides toward beta-glucuronidase were similar to that of saccharic acid 1,4-lactone. 3. These results indicate that plant materials of Kampo (Japanese herbal) medicines containing these glucuronides could be used in vivo to decrease the enterohepatic circulation of SN-38 and possibly that of other drugs.