gebhart/patrepeval huggingface dataset:
Antigenicity of Cholera Toxoid in Humans (1977)

A cholera toxoid was produced by heating of a purified cholera toxin and treatment of the resulting toxoid procholeragenoid with a formaldehyde solution. When given subcutaneously and intramuscularly to volunteers in doses of 3-100 microng, the toxoid produced no noteworthy side effects, but the injections produced a dose-dependent rise in level of toxin-neutralizing antibodies in serum. Administration of toxoid in combination with whole-cell vaccine induced antitoxin levels that seemed to be higher than those induced by toxoid alone, but statistical analysis revealed a significant difference only between titers after administration of 10 microng of toxoid alone and those after administration of 10 microng of toxoid in combination with whole-cell vaccine.
Treponema phagedenis has at least two proteins residing together on its periplasmic flagella (1986)

Treponema phagedenis is an anaerobic, motile spirochete with several periplasmic flagella (PFs) at each cell end. This study provides the first genetic evidence that multiple protein species are associated with the PFs. In addition, these proteins were found to reside together on a given PF. Nonmotile mutants which lacked the PFs were isolated, and spontaneous revertants to motility regained the PFs. These results suggest that the PFs are involved in the motility of T. phagedenis. Isolated PFs had two major protein bands with molecular weights of 33,000 and 39,800, as revealed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Western blots with monoclonal and polyclonal antibodies indicated that both proteins were absent in the PF mutants but present in the revertants. Immunoelectron microscopy revealed that the 39,800-molecular-weight protein was distributed along the entire PF. Immunoprecipitation analysis suggested that the 39,800- and 33,000-molecular-weight proteins were closely associated in situ.
Single-tree method for grammar-directed search (1999)

We present a very fast and accurate fast-match algorithm which, when followed by a regular beam search restricted within only the subset of words selected by the fast-match, can speed up the recognition process by at least two orders of magnitude in comparison to a typical single-pass speech recognizer utilizing the Viterbi (or beam) search algorithm. In this search strategy, the recognition vocabulary is structured as a single phonetic tree in the fast-match pass. The search on this phonetic tree is a variation of the Viterbi algorithm. Especially, we are able to use a word bigram language model without making copies of the tree during the search. This is a novel fast-match algorithm that has two important properties: high-accuracy recognition and run-time proportional to only the cube root of the vocabulary size.
A real-time RTL engineering-change method supporting on-line debugging for logic-emulation applications (1997)

In recent years, logic emulation has been widely used as a key design veri cation methodology in many complex CPU, telecom, and multimedia design projects. When using logic emulation for design veri cation, designers often need t o p erform engineering changes as a r esult of design debugging of a design speci cation modi cation. One of the essential issues to engineering changes is the turn-around time. Ideally, after designers modify their designs, they resume their debugging and veri cation tasks immediately. However, converting a design from its Register-Transfer-Level RTL description to a target emulator is a time-consuming procedure which may take hours. Such long engineeringchange turn-around times are unacceptable by the designers. In this paper, we present a real-time RTL engineering-change method supporting on-line debugging for logic-emulation applications. We propose a novel design method which is able to link design data generated at di erent design stages in a uni ed way. Using this method, the users can immediately locate the portion of the circuit design a ected by the design modi cation from its RTL speci cation. This feature p r ovides users with a fast time-to-debug environment by signi cantly improving the e ciency of the engineering-change process. We have developed a p r ototype system Quick ECO supporting interactive on-line RTL engineering changes. Experimental results on a number of industrial designs are reported to demonstrate the e ectiveness of the proposed method.
Transforming growth factor-alpha is a potential mediator of estrogen action in the mouse uterus. (1992)

To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the expression of transforming growth factor-alpha (TGF alpha) in mouse uterus was investigated. Our results show that estrogen induces the expression of TGF alpha mRNA in the mouse uterus in a dose- and time-dependent manner. The up-regulation of TGF alpha transcripts occurs predominantly in uterine epithelial cells. RIA and Western blot analysis demonstrate that immunoreactive TGF alpha protein is secreted at high levels into mouse uterine luminal fluid after estrogen treatment. The induction of uterine TGF alpha mRNA is specific to estrogen; nonestrogenic steroids did not induce expression. Antibody specific to TGF alpha significantly reduces estrogen-mediated uterine growth, which supports the concept that TGF alpha is a mitogen for the reproductive tract. Analysis of TGF alpha/EGF receptors by binding, affinity labeling, and phosphorylation studies indicates that functional receptors are present in the mouse uterus after estrogen exposure. Thus, our data support a physiological role for TGF alpha and its receptor pathway in the female mouse reproductive tract.
A novel cache architecture with enhanced performance and security (2008)

Caches ideally should have low miss rates and short access times, and should be power efficient at the same time. Such design goals are often contradictory in practice. Recent findings on efficient attacks based on information leakage in caches have also brought the security issue up front. Design for security introduces even more restrictions and typically leads to significant performance degradation. This paper presents a novel cache architecture that can simultaneously achieve the above goals. Specifically, cache miss rates are reduced with dynamic remapping and longer cache indices, access-time overhead overcome with astute low-level circuit design, and information leakage thwarted by a security-aware cache replacement algorithm together with the performance enhancing mechanisms. We present both theoretical analysis and experimental results, using the SPEC2000 suite to evaluate the cache miss behavior, and CACTI and HSPICE to validate the circuit design. Our results show that the proposed cache architecture has low miss rates comparable to a highly associative cache and short access times and power efficiency close to that of a direct-mapped cache. At the same time it can thwart cache-based software side-channel attacks, providing both legacy and security-enhanced software a much higher degree of security. Additional benefits that the proposed cache architecture can bring, like fault tolerance and hot-spot mitigation, are also discussed briefly.
An approach for virtual machine image security (2014)

Cloud security being the main hindrance in adoption of cloud computing has some most vulnerable security concerns as: virtualization, data and storage. Here, to provide virtualization security, the components of virtualization (such as hypervisors, virtual machines, and virtual machine images) must be secured using some improvised security mechanisms. Amongst all components, Virtual machine images (VM images) are considered to be the fundamental of whole cloud security. Hence must be secured from every possible attack. In this paper, a security protocol is proposed to mainly protect the VM images from two of the possible attacks. One is the channel attack like man-in-the-middle attack (MITM attack) and second is the attack by a malicious executing environment. It is using a concept of symmetric key's component distribution providing an integrity based confidentiality and self-protection. This protection is based on an encapsulated mobile agent. Here one key component is generated and distributed in a secure manner and the other key component is derived by host platform itself using its own available resource configuration information. In order to verify the validity of this approach in overcoming different kind of security attacks, BAN logic based formal representation is presented.
CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells (2002)

At present most treatments for cancers are designed to eliminate cancer cells directly. In a landmark publication nearly 30 years ago, Folkman (1) proposed antiangiogenesis as a potential target in cancer therapy. Numerous investigators have since attempted to exploit this concept (for recent reviews see refs. 2,3). In particular, the development of monoclonal antibodies (MAbs) directed against tumor endothelium has attracted the greatest attention. The progressive growth of solid tumors beyond a few mm3 requires the continuous formation of new blood vessels, a process known as tumor angiogenesis (1,4). Tumor growth and metastasis are angiogenesisdependent. Therefore, either prevention of tumor angiogenesis (antiangiogenic therapy)* or selective destruction of tumor’s existing blood vessels (vascular targeting therapy)* may be a potentially effective strategy for the treatment of solid tumors and control of tumor metastasis (1,5–8).
Chemical synthesis and properties of analogs of adenosylcobalamin (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical synthesis and properties of analogs of adenosylcobalaminHarry P. C. HogenkampCite this: Biochemistry 1974, 13, 13, 2736–2740Publication Date (Print):June 1, 1974Publication History Published online1 May 2002Published inissue 1 June 1974https://pubs.acs.org/doi/10.1021/bi00710a012https://doi.org/10.1021/bi00710a012research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pharmacogenetics of Tamoxifen Biotransformation Is Associated With Clinical Outcomes of Efficacy and Hot Flashes (2005)

In tamoxifen-treated patients, women with the CYP2D6 *4/*4 genotype tend to have a higher risk of disease relapse and a lower incidence of hot flashes, which is consistent with our previous observation that CYP2D6 is responsible for the metabolic activation of tamoxifen to endoxifen.
The Measurement of the Aeration of Culture Media (1951)

SUMMARY: The aeration of culture media can be measured in terms of ø L (defined below) which is dependent on rate of air flow, agitation, etc. Two methods of measuring ø L are given, based on the polarographic estimation of dissolved oxygen. For penicillin and streptomycin fermentations there is a correlation between the amount of antibiotic produced and ø L.
VIDRIOS ROMANOS DEL MUSEO DE CIUDAD REAL (1990)

Revista especializada en la publicación de trabajos originales de investigación en Prehistoria y Arqueología. Es la publicación periódica más antigua de la UAM. Su enfoque abierto a cualquier temática y época pasada, hasta la más cercana, que sea objeto de la Ciencia arqueológica se abre a una decidida proyección internacional en la que quiere basar su futuro inmediato.
Critical appraisal of the current practice in murine TNBS-induced colitis (2006)

There is no standard practice in the induction of colitis by 2,4,6-trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6-trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendations for the future use of the model.
Ultra-fast photoacoustic flow cytometry with a 05 MHz pulse repetition rate nanosecond laser (2010)

In vivo photoacoustic (PA) flow cytometry (PAFC) has great potential for detecting disease-associated biomarkers in blood and lymph flow, as well as real-time control of the efficacy of photothermal (PT) and other therapies through the counting of circulating abnormal objects. We report on a high speed PAFC with a Yb-doped fiber laser having a 0.5-MHz pulse repetition rate at a wavelength of 1064 nm, pulse width of 10 ns, and energy up to 100 microJ. This is the first biomedical application of PA and PT techniques operating at the highest pulse repetition rate of nanosecond lasers that provide 100-fold enhancement in detection speed of carbon nanotube clusters, as well as real-time monitoring of the flow velocity of individual targets through the width of PA signals. The laser pulse rate limits for PT and PA techniques depending on the sizes of laser beam and targets and flow velocity are discussed. We propose time-overlapping mode and generation of periodic nano- and microbubbles as PA-signal and PT-therapy amplifiers, including discrimination of small absorbing targets among large ones. Taking into account the relatively low level of background signals from most biotissues at 1064 nm, our data suggest that a nanosecond Yb-doped fiber laser operating at high pulse repetition rate could be a promising optical source for time-resolved PA and PT cytometry, imaging, microscopy, and therapy, including detection of nanoparticles and cells flowing at velocities up to 2.5 m/s.
Elucidation of discontinuous linear determinants in peptides. (1990)

Synthetic peptides, made by the method of simultaneous multiple peptide synthesis, were coupled to the protein carrier keyhole limpet hemocyanin and used to raise mAb. Omission and substitution analogs of the original peptides were tested by ELISA to characterize their reactivity with the respective mAb. Linear antigenic determinants were located for 18 different peptides by using omission analogs. The length of the antigenic determinants ranged from 2 to 8 residues, with an average of 6 residues. The three aromatic amino acids, phenylalanine, tryptophan, and tyrosine, the charged hydrophilic amino acids, aspartic acid and lysine, and the neutral amino acid alanine were found to occur most often in the determinant region of the peptides tested, whereas asparagine, cysteine, and histidine occurred the least often. Alanine substitution analogs provided more information than omission analogs by enabling the determination of which side chain groups of the antigenic determinant residues were not critical for binding to the mAb. Detailed, "fingerprint" information about the interaction of the peptide, GASPYPNLSNQQT, and its mAb was obtained by synthesizing a complete series of analogs with individual substitutions for each position of the antigenic determinant, PYPNLS, with the 19 other amino acids. These results suggest that, at the amino acid level, all antigenic determinants of synthetic peptides defined by mAb can be considered discontinuous linear determinants.
Gemcitabine Combined with Gefitinib in Patients with Inoperable or Metastatic Pancreatic Cancer: A Phase II Study of the Hellenic Cooperative Oncology Group with Biomarker Evaluation (2008)

The combination of gemcitabine and gefitinib was evaluated in advanced pancreatic cancer. Totally, 53 patients were treated with a 7 week cycle of gemcitabine (1,000 mg/m(2) given weekly) followed by six 4 week cycles of gemcitabine given on days 1, 8 and 15. Gefitinib 250 mg was administered daily. Responses were seen in 6, and stabilization of the disease in 12 patients. The main toxicity was myelotoxicity (92%). The 6-month progression-free survival (PFS) was 30%. Median PFS was 4.1 months and median survival 7.3 months with a 1 year survival rate of 27%. The above combination demonstrated promising activity in advanced pancreatic cancer.
The Melanopic Sensitivity Function Accounts for Melanopsin-Driven Responses in Mice under Diverse Lighting Conditions (2013)

In addition to rods and cones, photoreception in mammals extends to a third retinal cell type expressing the photopigment melanopsin. The influences of this novel opsin are widespread, ranging from pupillary and circadian responses to brightness perception, yet established approaches to quantifying the biological effects of light do not adequately account for melanopsin sensitivity. We have recently proposed a novel metric, the melanopic sensitivity function (V(Z)λ), to address this deficiency. Here, we further validate this new measure with a variety of tests based on potential barriers to its applicability identified in the literature or relating to obvious practical benefits. Using electrophysiogical approaches and pupillometry, initially in rodless+coneless mice, our data demonstrate that under a very wide range of different conditions (including switching between stimuli with highly divergent spectral content) the V(Z)λ function provides an accurate prediction of the sensitivity of melanopsin-dependent responses. We further show that V(Z)λ provides the best available description of the spectral sensitivity of at least one aspect of the visual response in mice with functional rods and cones: tonic firing activity in the lateral geniculate nuclei. Together, these data establish V(Z)λ as an important new approach for light measurement with widespread practical utility.
Effects of focusing on the scattering of sound by sound (1989)

The effects of absorption on the scattering of sound by sound were discussed by the authors at the previous meeting [J. Acoust. Soc. Am. Suppl. 1 85, S5 (1989)]. In the present paper, the effects of focusing are considered. The Khokhlov-Zabolotskaya-Kuznetsov equation is used to derive asymptotic results for the sum and difference frequency sound that is generated by the noncollinear interaction of focused sound beams radiated from displaced Gaussian sources. As in the case of unfocused primary beams, there are two main contributions to the nonlinearly generated sound field: pumped sound and scattered sound. Attention is devoted to the effects of focusing on the relative and absolute levels of the pumped and scattered waves. Strong focusing causes the pumped and scattered sound fields to broaden and overlap, which increases the difficulty of identifying the scattered sound. Numerical results are presented. [Work supported by ONR (CMD and MFH), IR&amp;D Program of ARL:UT, and VISTA/STATOIL (JNT and ST).]
Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR (2013)

MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3' untranslated regions, primarily via seed sequences (nucleotides 2 to 8 in the mature miRNA sequence). A number of individual miRNAs and miRNA families share seed sequences and targets, but differ in the sequences outside of the seed. miRNAs have been implicated in the etiology of a wide variety of human diseases and therefore represent promising therapeutic targets. However, potential redundancy of different miRNAs sharing the same seed sequence and the challenge of simultaneously targeting miRNAs that differ significantly in nonseed sequences complicate therapeutic targeting approaches. We recently demonstrated effective inhibition of entire miRNA families using seed-targeting 8-mer locked nucleic acid (LNA)-modified antimiRs in short-term experiments in mammalian cells and in mice. However, the long-term efficacy and safety of this approach in higher organisms, such as humans and nonhuman primates, have not been determined. We show that pharmacological inhibition of the miR-33 family, key regulators of cholesterol/lipid homeostasis, by a subcutaneously delivered 8-mer LNA-modified antimiR in obese and insulin-resistant nonhuman primates results in derepression of miR-33 targets, such as ABCA1, increases circulating high-density lipoprotein cholesterol, and is well tolerated over 108 days of treatment. These findings demonstrate the efficacy and safety of an 8-mer LNA-antimiR against an miRNA family in a nonhuman primate metabolic disease model, suggesting that this could be a feasible approach for therapeutic targeting of miRNA families sharing the same seed sequence in human diseases.
A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. (1993)

Monoclonal antibody PR1 binds to the surface of normal prostate cells and to adenocarcinomas of the prostate. The cDNAs coding for the heavy and light chain variable regions of monoclonal antibody PR1 were cloned by PCR techniques. A recombinant toxin was then constructed that has the heavy chain variable region of monoclonal antibody PR1 connected to the light chain variable region by a flexible peptide linker to create a single-chain Fv; the Fv in turn is fused to a truncated form of Pseudomonas exotoxin. The resulting recombinant immunotoxin PR1(Fv)-PE38KDEL was produced in Escherichia coli and accumulated in inclusion bodies. After denaturation and renaturation, active monomeric molecules with a molecular mass of approximately 65 kDa were purified to homogeneity. PR1(Fv)-PE38KDEL binds specifically to cells containing the PR1 antigen and is very cytotoxic toward a subset of LNCaP cells that express the PR1 antigen on their surface.
Application integration: Constructing composite applications from interactive components (1993)

Abstract Creating new applications by integrating user interface and application components is a relatively new idea which is currently of wide interest. A significant part of this problem is clearly defining the separation between user interface and application components. This paper proposes a new design methodology based on the concept of an abstract data view (ADV), a structuring method which cleanly defines this separation. A number of examples of composite interactive documents, ones which could contain several different user interfaces with entities such as text, calculations, drawings and possibly even multi‐media presentations, illustrate the ADV concept. These examples lead naturally to the introduction of the concept of hole , a user interface area in a composite interactive document which is managed by an external program, and uses ADVs. Prototypes of a number of systems supporting ADVs and holes are currently running in our laboratory.
The Influence of Androgen Deprivation Therapy on Dihydrotestosterone Levels in the Prostatic Tissue of Patients with Prostate Cancer (2004)

The source of dihydrotestosterone in prostatic tissue after androgen deprivation therapy involves intracrine production within the prostate, converting adrenal androgens to dihydrotestosterone. Dihydrotestosterone still remaining in prostate tissue after androgen deprivation therapy may require new therapies such as treatment with a combination of 5alpha-reductase inhibitors and antiandrogens, as well as castration.