gebhart/patrepeval huggingface dataset:
[Cantonese population data of the tetranucleotide repeat locus D7S809 and its application in paternity test]. (2001)

The tetranucleotide repeat locus D7S809 was investigated in Cantonese population by polymerase chain reaction (PCR) amplification, subsequent polyacryramide gel electrophoresis and silver staining. 14 alleles and 50 genotypes were detected in 190 sample individuals. All alleles differed in size by 4 bp repeat. No interalleles were found. The heterozygosity, power of discrimination and chance of non-paternal exclusion were 0.8613, 0.9645 and 0.7184 respectively. No significant deviations from Hardy-Weinberg equilibrium were found. The D7S809 was a highly polymorphic, stable and accurate type locus and had been successfully applied to 100 paternity test cases.
In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment (1998)

How multiple chemoattractants cooperate in directing the migration of hematopoietic progenitor cells (HPC) for homing and peripheral blood mobilization has not yet been established. We report here the behavior of HPC under the influence of two different chemoattractants, stromal cell-derived factor (SDF)-1 and steel factor (SLF), and the chemotactic nature of the bone marrow (BM) environment using a two-chamber in vitro migration system. Various formulae were adopted to quantitate these effects. Based on these quantitations, SDF-1 showed only chemotactic activity, while SLF showed both chemotactic and chemokinetic activities on factor-dependent MO7e cells. SLF, like SDF-1, attracted human HPC from a population of CD34+ cells and induced actin polymerization in MO7e cells. SLF and SDF-1 cooperated in attracting MO7e cells, as well as cord blood (CB) and BM CD34+ cells. A negative concentration gradient of SLF and SDF-1, formed by the presence of chemoattractants in the upper chamber, showed potent inhibitory effects on MO7e cell migration induced by either of these chemoattractants in the lower chamber, and SDF-1 and SLF were synergistic in mobilizing cells to the lower chamber from this negative chemoattractant gradient. Plasma obtained from BM aspirates, but not CB or peripheral blood, showed strong chemotactic effects on BM and CB CD34+ cells, and an inhibitory effect in a negative gradient on SDF-1-dependent CD34+ cell migration. These in vitro migration experiments suggest that chemoattractants such as SDF-1 and SLF with other unidentified BM chemoattractants may be involved cooperatively in the migration of HPC to the BM and in preventing spontaneous mobilization of HPC out of the BM.
p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest (2008)

microRNAs provide a novel layer of regulation for gene expression by interfering with the stability and/or translation of specific target mRNAs. Overall levels of microRNAs are frequently down-regulated in cancer cells, and reducing general microRNA processing increases cancerogenesis in transgenic models, suggesting that at least some microRNAs might act as effectors in tumor suppression. Accordingly, the tumor suppressor p53 up-regulates miR-34a, a microRNA that contributes to apoptosis and acute senescence. Here, we used array hybridization to find that p53 induces two additional, mutually related clusters of microRNAs, leading to the up-regulation of miR-192, miR-194, and miR-215. The same microRNAs were detected at high levels in normal colon tissue but were severely reduced in many colon cancer samples. On the other hand, miR-192 and its cousin miR-215 can each contribute to enhanced CDKN1A/p21 levels, colony suppression, cell cycle arrest, and cell detachment from a solid support. These effects were partially dependent on the presence of wild-type p53. Antagonizing endogenous miR-192 attenuated 5-fluorouracil-induced accumulation of p21. Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest.
Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function (2008)

Increasing evidences suggest that the aberrant expression of certain gangliosides on malignant cells could affect host's anti-tumour-specific immune responses. We have recently documented the relevance of the N-glycolylated variant of GM3 ganglioside (NGcGM3), a tumour-specific non-human sialic acid containing ganglioside, for tumour progression. However, evidences about the implication of host's immunity in NGcGM3-promoted cancer progression had not been obtained previously. In this work, we compared tumour growth of X63 myeloma cells pre-treated or not with an inhibitor of the glucosylceramide synthase enzyme, in wild or CD4+ T cell-depleted BALB/c mice. Results clearly showed a relationship between the agonistic effect of NGcGM3 in tumour growth and the presence of CD4+ T lymphocytes. For the first time, a description of a ganglioside-differential effect over purified CD4+CD25- and naturally occurring regulatory CD4+CD25+ T cells is provided. While NGcGM3 similarly down-modulated the CD4 expression in both cell populations, the inhibitory capacity of the CD4+CD25+ lymphocytes and their proliferation, induced by an anti-CD3 mAb and IL2, were not modified. In a different fashion, a reduction in proliferative capacity and a noteworthy secretion of anti-inflammatory cytokines were detected when CD4+CD25- T cells were cultured in the presence of NGcGM3. Considering the relevance of dendritic cells (DC) on primary activation of T cells, the effect of NGcGM3 over DC differentiation and TLR4-mediated maturation was also assessed. Our results indicate that NGcGM3 contributes to cancer progression mainly by influencing DC and CD4+CD25- T lymphocyte functions, rather than increasing the inhibitory capacity of naturally occurring regulatory T cells.
A Dominant Stargardt's Macular Dystrophy Locus Maps to Chromosome 13q34 (1994)

A disease locus responsible for an autosomal dominant Stargardt's macular dystrophy is located on chromosome 13 band q34. Identification of the mutated gene at this locus will lead to a better understanding of macular degeneration.
Genetic relationships among the oral streptococci (1987)

Genetic relationships and species limits among the oral streptococci were determined by an analysis of electrophoretically demonstrable variation in 16 metabolic enzymes. Fifty isolates represented 40 electrophoretic types, among which the mean genetic diversity per locus was 0.857. Mannitol-1-phosphate dehydrogenase was not detected in isolates of the sanguis species complex, and glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were absent in species of the mutans complex. Clustering from a matrix of Gower's coefficient of genetic similarity placed the 40 electrophoretic types in 10 well-defined groups corresponding to the Streptococcus species S. mutans, S. sobrinus, S. cricetus, S. rattus, S. ferus, S. oralis (mitior), two distinct assemblages of S. sanguis strains, and two subdivisions of "S. milleri." The assignments of isolates to these groups were the same as those indicated by DNA hybridization experiments, and the coefficient of correlation between genetic distance estimated by multilocus enzyme electrophoresis and genetic similarity indexed by DNA hybridization was -0.897 (P less than 0.001) for 50 pairwise combinations of isolates. S. ferus, which is widely believed to be a member of the mutans complex, was shown to be phylogenetically closer to species of the sanguis complex.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (2008)

Although PCSK9 is a target for controlling hypercholesterolemia, our data indicate that upon hepatic damage, patients lacking PCSK9 could be at risk.
High-Power $\hbox{Yb}^{{\bm 3}{\bm +}}$-Doped Phosphate Fiber Amplifier (2009)

We report on the development of novel high-power light sources utilizing a Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> -doped phosphate fiber as the gain element. This host presents several key benefits over silica, particularly much higher Yb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> concentrations (up to 26 wt%), a 50% weaker stimulated Brillouin scattering (SBS) gain cross section, and the absence of observable photodarkening even at high population inversion. These properties result in a greatly increased SBS threshold compared to silica fibers, and therefore, potentially much higher output powers out of either a multimode large mode area or a single-mode fiber, which means in the latter case a higher beam quality. To quantify these predictions, we show through numerical simulations that double-clad phosphate fibers should produce as much as ~ 700 W of single-frequency output power in a step index, single-mode core. As a step in this direction, we report a short phosphate fiber amplifier doped with 12 wt% Yb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> that emits 16 W of single-frequency single-mode output. We also describe a single-mode phosphate fiber laser with a maximum output power of 57 W. The laser slope efficiency is currently limited by the fairly high fiber loss ( ~ 3 dB/m). Measurements indicate that 77% of this loss originates from impurity absorption, and the rest from scattering.
네트워크 시대 영화법의 개정 방향 (2008)

Philip Cooke, media theorist, who analysed dynamics between new media and new economy, has suggested that new media is similar to new economy sectors like IT and biotechnology. Because economy markets are dynamic, its contribution has shown the creative spirits, innovative ideas and social interactions that make new media possible as commercial products are clustered in localized spaces of the new economy. The key feature of clusters is that they are dynamic. A cluster is an arena of dense and changing vertical input-output linkages, supply chains and horizontal interfirm networks. So Cooke defined the cluster as geographically proximate firms in vertical and horizontal relationships, involving a localized enterprise support infrastructure with a shared developmental vision for business growth, based on competition and cooperation in a specific market field. As Cooke suggested above, Korean cinema law in revision must reflect the changing media circumstances. The first of these is that there should be a definite distinction between profit cinema and non-profit one. Second, revising cinema law must discriminate in favor of culture technology. Third, it should reflect the side of cinema education. Fourth, it be revised to intensify a clarity of cinema industry and non-profit cinema.
White light-emitting diodes of GaN-based Sr2SiO4:Eu and the luminescent properties (2003)

We have synthesized a Eu2+-activated Sr2SiO4 yellow phosphor and investigated an attempt to develop white light-emitting diodes (LEDs) by combining it with a GaN blue LED chip. Two distinct emission bands from the GaN-based LED and the Sr2SiO4:Eu phosphor are clearly observed at 400 nm and at around 550 nm, respectively. These two emission bands combine to give a spectrum that appears white to the naked eye. Our results showed that GaN (400-nm chip)-based Sr2SiO4:Eu exhibits a better luminous efficiency than that of the industrially available product InGaN (460-nm chip)-based YAG:Ce.
THE MACROMOLECULAR ORGANIZATION OF MEMBRANES AND ITS BEARING ON EVENTS LEADING UP TO FERTILIZATION (1975)

Summary. Current concepts of the macromolecular organization of membranes and of ways in which membrane organization may change during membrane fusion are considered briefly. The properties of the sperm membrane at different phases of its development up to fertilization are then examined in the light of this more general model.
Iterative multiuser interference reduction: turbo CDMA (1999)

We view the asynchronous random code division multiple-access (CDMA) channel as a time-varying convolutional code. We study the case where the users encode their data, and, therefore, the single user transmitters and the CDMA channel appear as the concatenation of two coding systems. At the receiver we employ serial turbo decoding strategies. Unlike conventional turbo codes where both the inner and outer code may be selected, in our case, the inner code is due to the CDMA channel which we assume to be random. Nevertheless, the decoding system resembles the decoder of a serial turbo code and single-user performance is obtained even for numbers of users approaching the spreading code length.
VITAMIN B12 DEFICIENCY IN THE ELDERLY (1999)

A COMMON CONDITION: Vitamin B12 deficiency is common in the elderly. Search for deficiency should be undertaken whenever the clinical situation could lead to vitamin deficiency whether macrocytic anemia is present or not as its development may come late. PATHOPHYSIOLOGICAL IMPLICATIONS: The potential relationships between degenerative neuropsychiatric disorders and cerebrovascular or cardiovascular disease, mainly via hyperhomocysteinemia, emphasize the importance of searching for vitamin B12 deficiency in the elderly. SPECIFIC CAUSES: In the elderly, it is important to recognize specific causes of vitamin B12 deficiency, mainly resulting from vitamin malabsorption.
The Bureaucratization of War: Moral Challenges Exemplified by the Covert Lethal Drone (2013)

This paper interrogates the bureaucratization of war, incarnate in the covert lethal drone. Bureaucracies are criticized typically for their complexity, inefficiency, and inflexibility. The present paper is concerned with their moral indifference. We explore killing, which is so highly administered, so morally remote, and of such scale, that we acknowledge a covert lethal program. This is a bureaucratized program of assassination in contravention of critical human rights.
Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. (1990)

Abstract We have isolated and sequenced cDNA clones encoding the human homolog of the mouse Lyb-2 B cell differentiation Ag. Previous data suggest that Lyb-2 might represent a growth factor or lymphokine receptor. Human Lyb-2 mRNA is expressed in normal human tonsils and bone marrow cells, in the pre-B cell line REH, in three Burkitt lymphoma cell lines, and in some EBV-transformed B cell lines, but not in antibody-secreting myeloma cell lines, T cell lines, or a promyelocytic leukemia cell line. These data indicate that expression of human Lyb-2 is restricted to B lineage cells and turned off in antibody-secreting plasma cells. A polyclonal mouse antiserum was raised against human Lyb-2 and immunoprecipitates a Mr 42,000 protein from REH, Raji, and Daudi cells and from mouse L(tk) cells transfected with the human Lyb-2 cDNA in an expression vector. The human Lyb-2 protein is related to both the asialoglycoprotein receptor and CD23, the B cell-specific FcR for IgE. These data demonstrate that human B cells express a previously undescribed cell surface protein that is homologous to mouse Lyb-2 and has a similar pattern of expression during B cell development.
Controversies and Contradictions in Statistical Process Control (2000)

AbstractStatistical process control (SPC) methods are widely used to monitor and improve manufacturing processes and service operations. Disputes over the theory and application of these methods are frequent and often very intense. Some of the controversies and issues discussed are the relationship between hypothesis testing and control charting, the role of theory and the modeling of control chart performance, the relative merits of competing methods, the relevance of research on SPC and even the relevance of SPC itself. One purpose of the paper is to offer a resolution of some of these disagreements in order to improve the communication between practitioners and researchers.KeywordsAverage Run LengthControl ChartsCumulative Sum Control ChartsExponentially Weighted Moving Average Control Charts Additional informationNotes on contributorsWilliam H. WoodallDr. Woodall is a Professor in the Department of Statistics. He is a Fellow of ASQ. His e-mail address is bwoodall@vt.edu.
Influence of mesh density on a finite element model’s response under dynamic loading (2009)

International audience
Highly Hydrophilic Polyvinylidene Fluoride (PVDF) Ultrafiltration Membranes via Postfabrication Grafting of Surface-Tailored Silica Nanoparticles (2013)

Polyvinylidene fluoride (PVDF) has drawn much attention as a predominant ultrafiltration (UF) membrane material due to its outstanding mechanical and physicochemical properties. However, current applications suffer from the low fouling resistance of the PVDF membrane due to the intrinsic hydrophobic property of the membrane. The present study demonstrates a novel approach for the fabrication of a highly hydrophilic PVDF UF membrane via postfabrication tethering of superhydrophilic silica nanoparticles (NPs) to the membrane surface. The pristine PVDF membrane was grafted with poly(methacrylic acid) (PMAA) by plasma induced graft copolymerization, providing sufficient carboxyl groups as anchor sites for the binding of silica NPs, which were surface-tailored with amine-terminated cationic ligands. The NP binding was achieved through a remarkably simple and effective dip-coating technique in the presence or absence of the N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) cross-linking process. The properties of the membrane prepared from the modification without EDC/NHS cross-linking were comparable to those for the membrane prepared with the EDC/NHS cross-linking. Both modifications almost doubled the surface energy of the functionalized membranes, which significantly improved the wettability of the membrane and converted the membrane surface from hydrophobic to highly hydrophilic. The irreversibly bound layer of superhydrophilic silica NPs endowed the membranes with strong antifouling performance as demonstrated by three sequential fouling filtration runs using bovine serum albumin (BSA) as a model organic foulant. The results suggest promising applications of the postfabrication surface modification technique in various membrane separation areas.
A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines (1994)

We have constructed stable human immunodeficiency virus (HIV) packaging cell lines that when transfected with an HIV-based retroviral vector produce packaged vectors capable of transducing susceptible CD4+ cells. This HIV-1-based retroviral vector system has the potential for providing targeted delivery and regulated expression of immunogens or antiviral agents in CD4+ cells.
Military TBI During the Iraq and Afghanistan Wars (2006)

Traumatic brain injury (TBI) is an important source of morbidity in the Iraq and Afghanistan wars. Although penetrating brain injuries are more readily identified, closed brain injuries occur more commonly. Explosion or blast injury is the most common cause of war injuries. The contribution of the primary blast wave (primary blast injury) in brain injury is an area of active research. Lessons learned from the sports concussion and civilian mild TBI literature are useful. Individuals with TBI and posttraumatic stress disorder require treatment of both conditions. Families and communities need to be cognizant of the needs of these returning veterans.
Functional Group Diversity in Dendrimers (2002)

[structure: see text] A methodology for synthesizing dendrons with different peripheral functionalities is described. The benzyl ether-based dendrons reported here were synthesized using allyl and methoxymethyl ether-based protection-deprotection strategies.
Superconducting flux qubits for high-connectivity quantum annealing without lossy dielectrics (2017)

Quantum annealing can potentially be used to find better solutions to hard optimization problems faster than purely classical hardware. To take full advantage of quantum effects such as tunneling, a physical annealer should be comprised of qubits with a sufficient degree of quantum coherence. In addition, to encode useful problems, an annealer should provide a dense physical connectivity graph between qubits. Towards these goals, we develop superconducting ``fluxmon'' flux qubits suitable for high-connectivity quantum annealing without the use of performance-degrading lossy dielectrics. We carry out in-depth studies of noise and dissipation, and of qubit-qubit coupling in the strongly nonlinear regime. We perform the first frequency-resolved measurements extracting both the quantum and classical parts of the 1/f flux noise intrinsic to superconducting devices, and observe the classical-to-quantum crossover of the noise. We also identify atomic hydrogen as a magnetic dissipation source. We then implement tunable inter-qubit coupling compatible with high connectivity, and provide direct spectroscopic measurements of ultra-strong coupling between qubits. Finally, we use our system to explore quantum annealing faster than the system thermalization time, a previously unaccessed regime.
Comparison of the Coding Efficiency of Video Coding Standards—Including High Efficiency Video Coding (HEVC) (2012)

The compression capability of several generations of video coding standards is compared by means of peak signal-to-noise ratio (PSNR) and subjective testing results. A unified approach is applied to the analysis of designs, including H.262/MPEG-2 Video, H.263, MPEG-4 Visual, H.264/MPEG-4 Advanced Video Coding (AVC), and High Efficiency Video Coding (HEVC). The results of subjective tests for WVGA and HD sequences indicate that HEVC encoders can achieve equivalent subjective reproduction quality as encoders that conform to H.264/MPEG-4 AVC when using approximately 50% less bit rate on average. The HEVC design is shown to be especially effective for low bit rates, high-resolution video content, and low-delay communication applications. The measured subjective improvement somewhat exceeds the improvement measured by the PSNR metric.
The Estrogen/Neurotrophin Connection during Neural Development: Is Co-Localization of Estrogen Receptors with the Neurotrophins and Their Receptors Biologically Relevant? (1996)

Estrogen enhances neurite growth within the developing rodent forebrain. Estrogen receptor mRNA is co-expressed with the mRNA for the neurotrophins and their receptors. Estrogen may act independently by altering growth-related genes directly, but may interact additionally with growth factors (neurotrophins) and their receptors (trks). Estrogen may also act permissively to facilitate neurotrophin actions by genomic cross-talk with neurotrophin regulatory pathways whose nuclear end points may be the same estrogen-responsive genes. Differential and reciprocal regulation of estrogen and nerve growth factor (NGF) receptor gene expression by their ligands suggests that estrogen and the neurotrophins may influence each other's actions by regulating receptor/ligand availability or by reciprocal regulation at the level of gene transcription or signal transduction. Steroid/neurotrophin interactions may stimulate the synthesis of proteins required for neuronal differentiation, survival and maintenance of function.
The Possible Role of the Catecholamines of the Corpora in Penile Erection (1979)

The etiology of impotence, which effects 50 per cent of the men with diabetes, is unknown. The neurotransmitter (norepinephrine) released from adrenergic neurons is thought to be the most direct regulator of vascular smooth muscle. We have measured the norepinephrine content of the erectile tissue of diabetic men. Our results indicate the presence of a dual neural regulator mechanism of the corpora that controls penile erection.