gebhart/patrepeval huggingface dataset:
Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding (1997)

Units of 2-ureido-4-pyrimidone that dimerize strongly in a self-complementary array of four cooperative hydrogen bonds were used as the associating end group in reversible self-assembling polymer systems. The unidirectional design of the binding sites prevents uncontrolled multidirectional association or gelation. Linear polymers and reversible networks were formed from monomers with two and three binding sites, respectively. The thermal and environmental control over lifetime and bond strength makes many properties, such as viscosity, chain length, and composition, tunable in a way not accessible to traditional polymers. Hence, polymer networks with thermodynamically controlled architectures can be formed, for use in, for example, coatings and hot melts, where a reversible, strongly temperature-dependent rheology is highly advantageous.
Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy (2015)

Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability.
Overall survival (OS) in patients (Pts) with diagnostic positive (Dx+) breast cancer: Subgroup analysis from a phase 2 study of enzalutamide (ENZA), an androgen receptor (AR) inhibitor, in AR+ triple-negative breast cancer (TNBC) treated with 0-1 prior lines of therapy. (2017)

1089 Background: The AR may be a novel therapeutic target for pts with AR-driven TNBC. ENZA, a potent AR inhibitor approved in men with metastatic prostate cancer, was evaluated in this phase 2 study of pts with AR+ TNBC. A genomic signature associated with AR-driven biology was identified; updated OS results in pts treated with 0-1 prior lines of therapy are presented. Methods: This is an open-label, Simon two-stage study (NCT01889238) of ENZA monotherapy in advanced AR+ TNBC (AR &gt; 0% by IHC). Bone-only disease and unlimited prior regimens were allowed; CNS metastases or seizure history were exclusionary. The primary endpoint was clinical benefit rate at 16 weeks (CBR16) in evaluable pts (AR &gt; 10% and ≥1 postbaseline assessment). OS was an exploratory endpoint. Results in intent-to-treat (ITT) and evaluable pts were presented previously (Traina TA et al. J Clin Oncol. 2015;33:1003). Results: 118 pts were enrolled (ITT). CBR16 in 78 evaluable pts was 33.3%. Of the 118 ITT pts, 56 were Dx+ and 62 were Dx–; ≥50% received 0-1 prior lines of therapy (28 Dx+, 37 Dx–). As of 26 Nov 2016 there were 83 deaths (median follow-up 28 mo); median OS (mOS) was 13 mo (95% CI; 8-18). In the Dx+ subgroup there were 32 deaths (mOS 20 mo [95% CI; 13-29]) vs 51 deaths in the Dx– subgroup (mOS 8 mo [95% CI; 5-11]). In pts with 0-1 prior lines of therapy, there were 13 deaths in the Dx+ subgroup (mOS 29 mo [95% CI; 19-not reached] vs 28 in the Dx– subgroup (mOS 10 mo [95% CI; 7-15]). The most common adverse events (AEs) were fatigue and nausea; fatigue was the only grade 3 related AE in &gt; 5% of pts. A multi-covariate Cox analysis identified Dx status (+ vs –) and line of therapy (0-1 vs ≥2) as the only variables significantly associated with OS. Conclusions: In this study, the mOS of pts with Dx+ TNBC who received 0-1 prior lines of therapy appears longer than that of unselected historic controls. ENZA may represent a therapeutic option in pts with AR+ TNBC who would otherwise receive cytotoxic chemotherapy and is currently being evaluated in ENDEAR, a phase 3 study in pts with Dx+ advanced TNBC and 0-1 prior lines of therapy. Clinical trial information: NCT01889238.
Urgency is a non-monotonic function of pulse rate (2007)

Magnitude estimation was used to assess the experience of urgency in pulse-train stimuli (pulsed white noise) ranging from 3.13 to 200 Hz. At low pulse rates, pulses were easily resolved. At high pulse rates, pulses fused together leading to a tonal sensation with a clear pitch level. Urgency ratings followed a nonmonotonic (polynomial) function with local maxima at 17.68 and 200 Hz. The same stimuli were also used in response time and pitch scaling experiments. Response times were negatively correlated with urgency ratings. Pitch scaling results indicated that urgency of pulse trains is mediated by the perceptual constructs of speed and pitch.
Emerging clinical applications of electrical stimulation: opportunities for restoration of function. (2002)

Emerging clinical application of electrical stimulation in three systems is reviewed. In the bladder, stimulation of sacral posterior roots reduces reflex incontinence and significantly improves bladder capacity. With the combination of anterior and posterior root stimulation, bladder control can be achieved without the need for rhizotomy. Preliminary research demonstrates that bladder contractions may also be generated by stimulation of the urethral sensory branch of the pudendal nerve, even after acute spinal cord transection, while inhibition of the bladder and control of urge incontinence can be achieved by stimulation of the whole pudendal nerve. Spinal cord stimulation can modulate the activity of the intrinsic cardiac nervous system involved in the regulation of regional cardiac function and significantly reduce the pain associated with angina pectoris. Finally in the area of upper airway disorders, functional electrical stimulation has great potential for increasing life support as well as for quality of life in chronic ailments, particularly obstructive sleep apnea and dysphagia.
Ocular Therapeutics: Pharmacology and Clinical Application (1997)

This therapeutic reference available worldwide, combines pharmacology and the clinical application of medications used in ophthalmology to provide ophthalmologists and eyecare practitioners the information needed to treat ocular conditions. Current concepts in medical therapy are reviewed for all common and many rare eye diseases. With this book, physicians can identify the signs and symptoms of eye diseases and administer the most current therapy. Ocular Therapeutics presents many treatment modalities, including new, controversial and possible future regimens. Many practical tips are provided, such as solutions not to mix, particular points to watch when applying painful medications, and where to obtain rare medications. This comprehensive resource is divided into two sections. The first consists of 10 chapters devoted to the pharmacology of drugs used in ophthalmology. These chapters establish a foundation of knowledge by offering background information on drug agents and medications, as well as their use in daily practice and mechanism of action. The second section follows through with 16 clinically based chapters, providing descriptions of disease entities involving the eye and adnexa, grouped according to anatomical location, and relates a short discussion on aetiology with practical suggestions for rational treatments. With over 2000 references, a wealth of cross-references and an extensive drug index, Ocular Therapeutics serves as both a comprehensive, up-to-date reference and a handy practical guide.
Surface Properties of Silk Fibroin Films and Their Interaction with Fibroblasts (2005)

There is a growing interest in the use of silk as a biomaterial for tissue engineering. Silk threads from Bombyx mori have a fibrous core of fibroin, the protein responsible for biocompatibility and bioactivity, which is surrounded by a family of "gummy" proteins, called sericins, which are almost completely removed during silk degumming. Three different methanol treatments on regenerated fibroin films were used to convert viscous solutions of Silk I to an insoluble crystalline form (Silk II), in an attempt to devise new processing protocols for the creation of a cell guiding fibroin surface. Human fibroblasts (MRC5 line) were used as probes of the cell-biomaterial interaction in the early stages of the process (1 h, 3 h, 6 h and 4 d after seeding). The effect of each treatment on cell adhesion, spreading and distribution was monitored by scanning electron microscopy (SEM) and was correlated to superficial properties (like roughness and crystallinity) and fibroin conformation by means of atomic force microscopy (AFM), used in both topographical and acoustic mode, and attenuated total internal reflection infrared spectroscopy (FTIR-ATR). It was found that traditional methanol treatments where fibroin films were soaked in methanol solution produced roughness patterns that affected only the very early stages of fibroblast adhesion (until 3 h from seeding), while the new treatment proposed could really dialogue with the cells. Its non-homogeneous surface can explain the existence of cells spreading in specific directions and the presence of cell repellent areas even 4 d after seeding.
Plasmonic Nanopore for Electrical Profiling of Optical Intensity Landscapes (2013)

We present a novel method for sensitive mapping of optical intensity distributions at subdiffraction-limited resolution. This is achieved with a novel device, a plasmonic nanopore, which combines a plasmonic bowtie nanoantenna with a 10 nm-in-diameter solid-state nanopore. Variations in the local optical intensity modulate the plasmonic heating, which we measure electrically through changes in the ionic conductance of the nanopore. We demonstrate the method by profiling the focal volume of a 10 mW laser beam that is tightly focused by a high-numerical-aperture microscope objective. The results show a complex three-dimensional intensity distribution that closely matches predictions obtained by theoretical calculations of the optical system. In addition to laser profiling, the ionic conductance of a nanopore is also shown to provide quantitative estimates of the temperature in the proximity of single plasmonic nanostructures.
Probabilistic motion pixel detection for the reduction of ghost artifacts in high dynamic range images from multiple exposures (2014)

Abstract This paper presents an algorithm for compositing a high dynamic range (HDR) image from multi-exposure images, considering inconsistent pixels for the reduction of ghost artifacts. In HDR images, ghost artifacts may appear when there are moving objects while taking multiple images with different exposures. To prevent such artifacts, it is important to detect inconsistent pixels caused by moving objects in consecutive frames and then to assign zero weights to the corresponding pixels in the fusion process. This problem is formulated as a binary labeling problem based on a Markov random field (MRF) framework, the solution of which is a binary map for each exposure image, which identifies the pixels to be excluded in the fusion process. To obtain the ghost map, the distribution of zero-mean normalized cross-correlation (ZNCC) of an image with respect to the reference frame is modeled as a mixture of Gaussian functions, and the parameters of this function are used to design the energy function. However, this method does not well detect faint objects that are in low-contrast regions due to over- or under-exposure, because the ZNCC does not show much difference in such areas. Hence, we obtain an additional ghost map for the low-contrast regions, based on the intensity relationship between the frames. Specifically, the intensity mapping function (IMF) between the frames is estimated using pixels from high-contrast regions without inconsistent pixels, and pixels out of the tolerance range of the IMF are considered moving pixels in the low-contrast regions. As a result, inconsistent pixels in both the low- and high-contrast areas are well found, and thus, HDR images without noticeable ghosts can be obtained.
Affinity labeling of rat liver thyroid hormone nuclear receptor. (1980)

The thyroid hormone receptor from rat liver nuclei has been covalently labeled with the N-bromoacetyl derivatives of L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3). Displacement binding studies showed that, in the presence of 100-fold molar excess of unlabeled N-bromoacetyl-T3 or T4, binding of [125I]T3 or [125I]T4 was nearly totally inhibited. Heat inactivation of the receptor (55 degrees C for 15 min) resulted in parallel losses in the binding of T3 (95%) and N-bromoacetyl-T3 (93%). These results indicated that T3 and T4 and their bromoacetyl derivatives compete for the same binding site. The nuclear receptor showed identical behavior in high-pressure liquid chromatography (HPLC) whether bound to T3 or T4 or covalently labeled with their bromoacetyl derivatives. HPLC provided a single-step 100-fold purification of the nuclear receptor. Na-DodSO4 gel electrophoresis of the nuclear receptor labeled with N-bromoacetyl derivatives of [125I]T3 or [125I]T4 showed one major radioactive component with a molecular weight of 56,000. Furthermore, in the absence of denaturant, the nuclear receptor either bound to [125I]T3 or covalently labeled with N-bromoacetyl-[125I]T3 showed identical mobility. These results suggested that the nuclear receptor is a single polypeptide chain and binds either T3 or T4. Nuclear receptors covalently linked with N-bromoacetyl derivatives of [125I]T3 or [125I]T4 may be useful as a marker for the preparative purification of receptor.
RSVP: a new resource ReSerVation Protocol (1993)

A resource reservation protocol (RSVP), a flexible and scalable receiver-oriented simplex protocol, is described. RSVP provides receiver-initiated reservations to accommodate heterogeneity among receivers as well as dynamic membership changes; separates the filters from the reservation, thus allowing channel changing behavior; supports a dynamic and robust multipoint-to-multipoint communication model by taking a soft-state approach in maintaining resource reservations; and decouples the reservation and routing functions. A simple network configuration with five hosts connected by seven point-to-point links and three switches is presented to illustrate how RSVP works. Related work and unresolved issues are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Oxidation and mass spectra of 4,4-dimethyloxazolidine-N-oxyl (doxyl) derivatives of ketones (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidation and mass spectra of 4,4-dimethyloxazolidine-N-oxyl (doxyl) derivatives of ketonesSunwen Chou, J. A. Nelson, and T. A. SpencerCite this: J. Org. Chem. 1974, 39, 16, 2356–2361Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://doi.org/10.1021/jo00930a006RIGHTS & PERMISSIONSArticle Views229Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (762 KB) Get e-Alerts Get e-Alerts
Comparison of the Regulation, Metabolic Functions, and Roles in Virulence of the Glyceraldehyde-3-Phosphate Dehydrogenase Homologues gapA and gapB in Staphylococcus aureus (2010)

The Gram-positive bacterium Staphylococcus aureus contains two glyceraldehyde-3-phosphate dehydrogenase (GAPDH) homologues known as GapA and GapB. GapA has been characterized as a functional GAPDH protein, but currently there is no biological evidence for the role of GapB in metabolism in S. aureus. In this study we show through a number of complementary methods that S. aureus GapA is essential for glycolysis while GapB is essential in gluconeogenesis. These proteins are reciprocally regulated in response to glucose concentrations, and both are influenced by the glycolysis regulator protein GapR, which is the first demonstration of the role of this regulator in S. aureus and the first indication that GapR homologues control genes other than those within the glycolytic operon. Furthermore, we show that both GapA and GapB are important in the pathogenesis of S. aureus in a Galleria mellonella model of infection, showing for the first time in any bacteria that both glycolysis and gluconeogenesis have important roles in virulence.
Daptomycin disrupts membrane potential in growing Staphylococcus aureus (1991)

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.
A simple method for the preparation of homogeneous phospholipid vesicles (1977)

A new method is described for the preparation of homogeneously sized, single-lamellar phospholipid vesicles. This method, wich is based on differential high-speed ultracentrifugation, has the advantages of a higher vesicle yield without dilution and rapidity of preparation when compared to the molecular-sieve technique. The homogeneity of vesicle dispersions, prepared by this new method, is examined by several physical techniques and found to be comparable to the best samples prepared by molecular-sieve chromatography.
Co‐Delivery of Oxaliplatin and Demethylcantharidin via a Polymer–Drug Conjugate (2013)

A Pt (IV) complex which combined the bioactivities of both oxaliplatin and demethylcantharidin (DMC) is synthesized and delivered by a polymer-drug conjugate for combination chemotherapy. Oxaliplatin is released from the polymer-drug conjugate within cancer cell by reduction to attack nuclear DNA, while a dose of DMC is also hydrolyzed subsequently to block DNA damage-induced defense mechanisms by serine/threonine phosphatase 2A (PP2A) inhibition. In vitro evaluation shows that the polymer-drug conjugate with dual modes of action upon cancer cells displays higher cytotoxicity against SKOV-3 cells than that of free drugs. This enhanced cytotoxicity is attributed to the synergistic effect between oxaliplatin and DMC, as well as the effective intracellular internalization of the micelles observed by confocal laser scanning microscopy (CLSM) imaging.
A New Approach Towards the Combined Algorithm Selection and Hyper-parameter Optimization Problem (2019)

Machine learning algorithms often have many hyper-parameters that can be tuned to improve empirical performance. However, manually exploring the complex search spaces is tedious and cannot guarantee to find satisfactory outcomes. Recently, the Efficient Global Optimization (EGO) algorithm for solving the hyper-parameter optimization problem have shown substantial improvements. However, these algorithms cannot easily be expanded to include the selection of an algorithm. Automatically determining and optimizing an algorithm is known as the combined algorithm selection and hyper-parameter optimization (CASH) problem. In this paper, a novel mixed integer efficient global optimization algorithm and its variants are proposed to solve the CASH problem efficiently. The proposed algorithm is compared with a wide set of state-of-the-art algorithms in both a Black Box Optimization and a CASH problem setting. For the CASH problem setup, seven machine learning algorithms are optimized for a large set of classification t asks. Results show that the proposed algorithms outperform on the black box optimization task and can also outperform alternative state-of-the-art approaches on the CASH problem for specific instances.
Transform Image Coding. (1978)

In recent years, considerable research effort has been done to optimize various digital communication channels. The significant growth of both commercial and military communication systems has emphasized the need for efficient data compression procedures. In the case of image transmission, the requirement is particularly demanding because of the significant amount of information to be transmitted. In this report, image compression procedures based on transform techniques are reviewed. The emphasis is on adaptive and, especially, on rate adaptive algorithms. The discussion includes an historical review, theoretical development, and illustrative examples of the transform image coding field. (Author)