gebhart/patrepeval huggingface dataset:
Epitope mapping of the branched chain alpha -ketoacid dehydrogenase dihydrolipoyl transacylase (BCKD-E2) protein that reacts with sera from patients with idiopathic dilated cardiomyopathy. (1994)

Sera from 29 of 48 patients with idiopathic dilated cardiomyopathy (IDCM) and six of six patients with dilated cardiomyopathy (DCM) secondary to suspected viral myocarditis were shown to react with the branched chain alpha-ketoacid dehydrogenase (BCKD) complex mitochondrial proteins. Whereas sera from only 1 of 26 patients with ischemic heart disease showed reactivity against the BCKD complex protein, 0 of 30 sera from normal human volunteers, 0 of 64 sera from patients with lupus, and 0 of 34 sera from patients with rheumatoid arthritis showed detectable reactivity, denoting an element of specificity for the reactivity of sera from IDCM patients. The major reactivity was localized to the dihydrolipoyl transacylase (E2) component of BCKD complex. By using recombinant techniques, the immunodominant BCKD-E2 epitope recognized by sera from IDCM patients was localized to amino acid (aa) sequences 116 to 134. Each of the IDCM sera that reacted with the native BCKD complex was shown to react with the immunodominant peptide, as defined by a peptide inhibition ELISA and by an ELISA using the reactive peptide conjugated to BSA. Sera from IDCM patients that reacted with the native BCKD complex and the reactive peptide also showed inhibition of BCKD enzyme activity. The possible mechanisms for the induction of the Abs and the implications of these findings for the pathogenesis of IDCM are discussed.
Analysis of Human Epidural Pressures (1992)

Lumbar epidural pressure is greater than atmospheric pressure when referenced to zero at the dorsal spine level.
Infections with Herpes Simplex Viruses (1986)

IN the 12 years since the last review of herpes simplex virus (HSV) infections in these pages,1 there have been substantial advances in our knowledge of the clinical manifestations, pathogenesis, and therapy of these infections. The epidemic of sexually transmitted HSV infection that has occurred in the past decade, the concomitant increase in neonatal herpes, and the increasing recognition of the diversity and morbidity of HSV infections in immunocompromised patients have heightened awareness of these agents among medical professionals, the public, and the press.2 3 4 5 6 The development of clinically useful antiviral therapy for HSV infections has made recognition of the clinical . . .
Control of surface functionality in the synthesis of dendritic macromolecules using the convergent-growth approach (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTControl of surface functionality in the synthesis of dendritic macromolecules using the convergent-growth approachCraig J. Hawker and J. M. J. FrechetCite this: Macromolecules 1990, 23, 21, 4726–4729Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ma00223a036https://doi.org/10.1021/ma00223a036research-articleACS PublicationsRequest reuse permissionsArticle Views576Altmetric-Citations162LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced Skin Regeneration by Herbal Extract‐Coated Poly‐L‐Lactic Acid Nanofibrous Scaffold (2017)

The wound healing process is directly related to the type of treatment. Existing methods of treatment are not responsive enough for severe wounds. The aim of this study was the potential capacity investigation of poly-L-lactic acid (PLLA) nanofibrous scaffolds coated by aloe vera gel for wound dressing applications. In this study, electrospinning method was used for preparing PLLA nanofibers, and after characterization by SEM and MTT, its influence on the wound healing process was investigated with and without aloe vera gel as a wound dressing in full-thickness skin defect in mice. Band-Aids were used as a positive control and vaseline gauze as a negative control. SEM and MTT assays confirmed the nanometer size and biocompatibility of fabricated nanofibers. Macroscopic and histopathological characteristics were evaluated at the end of days 7, 12, and 17 and their results showed that the gel-coated scaffold accelerated the wound-healing process compared with other groups. At the end of the experiment, it was shown that during the whole time of study, gel-coated scaffold had the highest overall repair score. Therefore, gel-coated PLLA scaffold would be an ideal construct for wound healing and skin regenerative medicine application.
Inhalation of Dry Powder Mannitol Improves Clearance of Mucus in Patients with Bronchiectasis (1999)

Bronchiectasis is a disease characterized by hypersecretion and retention of mucus requiring physical and pharmacologic treatment. Recently we reported that inhalation of dry powder mannitol markedly increases mucociliary clearance (MCC) in asthmatic and in healthy subjects (Daviskas, E., S. D. Anderson, J. D. Brannan, H. K. Chan, S. Eberl, and G. Bautovich. 1997. Inhalation of dry-powder mannitol increases mucociliary clearance. Eur. Respir. J. 10:2449-2454). In this study we investigated the effect of mannitol on MCC in patients with bronchiectasis. Eleven patients 40 to 62 yr of age inhaled mannitol (approximately 300 mg) from a Dinkihaler. MCC was measured over 90 min, in the supine position, on three occasions involving: mannitol or control or baseline, using a radioaerosol technique. On the control day patients reproduced the breathing maneuvers and the number of coughs induced by the mannitol. Mannitol significantly increased MCC over the 75 min from the start of the intervention compared with control and baseline in the whole right lung, central, and intermediate region. Mean (+/- SEM) clearance with mannitol was 34.0 +/- 5.0% versus 17.4 +/- 3.8% with control and 11.7 +/- 4.4% with baseline in the whole right lung (p < 0.0001). The mean number of coughs induced by mannitol was 49 +/- 11. In conclusion, inhalation of dry powder mannitol increased clearance of mucus and thus has the potential to benefit patients with bronchiectasis.
Big-Data Architecture for Cyber Attack Graphs Representing Security Relationships in NoSQL Graph Databases (2014)

Abstract—We introduce a new modeling framework for mapping vulnerability paths through networks and associating them with observed attacker activities. We merge a complex blend of network relationships and events, such as topology, firewall policies, host configurations, vulnerabilities, attack patterns, intrusion alerts, and logs. Our persistence layer includes Neo4j, a Not Only SQL (NoSQL) database optimized for graphs. We explore how the Neo4j property-graph data model supports analysis and queries within our problem domain. For interoperability with other tools, we employ standardized cyber-security data exchange language. We show that our approach supports the same kinds of graph analytics as an existing attack graph tool, through the application of the Neo4j Cypher query language. We then extend those analytics through a much richer model of the network environment and attacker/defender activities. Our work represents the first investigation of cyber attack graph analysis based on graph databases – an important class of NoSQL database. Keywords-attack graphs; topological vulnerability analysis; network attack modeling; cyber security standards; cluster computing; NoSQL databases I.
Linear optical quantum computing with photonic qubits (2007)

Linear optics with photon counting is a prominent candidate for practical quantum computing. The protocol by Knill, Laflamme, and Milburn [2001, Nature (London) 409, 46] explicitly demonstrates that efficient scalable quantum computing with single photons, linear optical elements, and projective measurements is possible. Subsequently, several improvements on this protocol have started to bridge the gap between theoretical scalability and practical implementation. The original theory and its improvements are reviewed, and a few examples of experimental two-qubit gates are given. The use of realistic components, the errors they induce in the computation, and how these errors can be corrected is discussed.
SYNTHESIS AND EVALUATION OF FLUORINE-18 LABELED ROTENONE ANALOGS (1994)

VanBrocklin, H. E.; O'Neil, J. P.; Enas, J. D.; Hanrahan, S. M.; Taylor, S. E. Author Information
A novel beta-thalassemia frameshift mutation (codon 14/15), detectable by direct visualization of abnormal restriction fragment in amplified genomic DNA (1988)

A new frameshift mutation due to an insertion of G between codon 14/15 of the beta-globin gene was found in two unrelated Chinese patients with Cooley's anemia. The first patient (W.S.) was homozygous for haplotype 5 (Chinese) and carried a codon 41/42 (four base pair deletion) mutant, while the second patient (C.K.) was homozygous for haplotype 2 (Chinese), and also had a codon 17 (A----T) nonsense mutation. Molecular cloning and M13 sequencing of the beta gene in patient W.S. revealed that the new mutant was found in a beta-globin gene framework type 3 (Asian). Direct sequencing was performed on polymerase chain reaction-amplified genomic DNA from patient C.K. With the new mutation, an additional BstNI or EcoRII recognition site is generated and the abnormal restriction fragment (134 basepair) can be directly visualized on polyacrylamide gel electrophoresis of the amplified genomic DNA.
LookinGood: Enhancing Performance Capture with Real-time Neural Re-Rendering (2018)

Motivated by augmented and virtual reality applications such as telepresence, there has been a recent focus in real-time performance capture of humans under motion. However, given the real-time constraint, these systems often suffer from artifacts in geometry and texture such as holes and noise in the final rendering, poor lighting, and low-resolution textures. We take the novel approach to augment such real-time performance capture systems with a deep architecture that takes a rendering from an arbitrary viewpoint, and jointly performs completion, super resolution, and denoising of the imagery in real-time. We call this approach neural (re-)rendering, and our live system "LookinGood". Our deep architecture is trained to produce high resolution and high quality images from a coarse rendering in real-time. First, we propose a self-supervised training method that does not require manual ground-truth annotation. We contribute a specialized reconstruction error that uses semantic information to focus on relevant parts of the subject, e.g. the face. We also introduce a salient reweighing scheme of the loss function that is able to discard outliers. We specifically design the system for virtual and augmented reality headsets where the consistency between the left and right eye plays a crucial role in the final user experience. Finally, we generate temporally stable results by explicitly minimizing the difference between two consecutive frames. We tested the proposed system in two different scenarios: one involving a single RGB-D sensor, and upper body reconstruction of an actor, the second consisting of full body 360 degree capture. Through extensive experimentation, we demonstrate how our system generalizes across unseen sequences and subjects. The supplementary video is available at http://youtu.be/Md3tdAKoLGU.
The Fuzzy logistics of intraflagellar transport (2012)

![Figure][1] 

IFT43 (green) localizes to the cilia of wild-type cells (left) but not cells lacking Fuz (right).



The planar cell polarity protein Fuzzy (Fuz) promotes ciliogenesis by delivering intraflagellar transport (IFT) proteins to the basal bodies of primary cilia, [Brooks and
VoIP Hacks : Tips & Tools for Internet Telephony (Hacks) (2005)

Voice over Internet Protocol (VoIP) is gaining a lot of attention these days, as more companies and individuals switch from standard telephone service to phone service via the Internet. The reason is simple: A single network to carry voice and data is easier to scale, maintain, and administer. As an added bonus, it's also cheaper, because VoIP is free of the endless government regulations and tariffs imposed upon phone companies. VoIP is simply overflowing with hack potential, and VoIP Hacks is the practical guide from O'Reilly that presents these possibilities to you. It provides dozens of hands-on projects for building a VoIP network, showing you how to tweak and customize a multitude of exciting things to get the job done. Along the way, you'll also learn which standards and practices work best for your particular environment. Among the quick and clever solutions showcased in the book are those for: gauging VoIP readiness on an enterprise network using SIP, H.323, and other signaling specifications providing low-layer security in a VoIP environment employing IP hardphones, analog telephone adapters, and softPBX servers dealing with and avoiding the most common VoIP deployment mistakes In reality, VoIP Hacks contains only a small subset of VoIP knowledge-enough to serve as an introduction to the world of VoIP and teach you how to use it to save money, be more productive, or just impress your friends. If you love to tinker and optimize, this is the one technology, and the one book, you must investigate.
Iodomethylzinc Phosphates:  Powerful Reagents for the Cyclopropanation of Alkenes (2005)

A new family of zinc carbenoids derived from phosphoric acids was developed and used in the cyclopropanation of allylic alcohols and ethers and also of unfunctionalized olefins. The use of the chiral phosphoric acid of a 3,3'-disubstituted BINOL leads to efficient stereocontrol, affording the cyclopropanes of allylic and homoallylic ethers with complete conversions and up to 93% ee. A catalytic version of this reaction using 10 mol % of the chiral phosphate reagent is also disclosed.
High Protein Diet and Huntington's Disease (2015)

Huntington's disease (HD) is a neurodegenerative disorder caused by the huntingtin (HTT) gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT) exists in the liver and causes urea cycle deficiency. A low protein diet (17%) restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories) than in mice (~22%). We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein) for 5 days, followed by a high protein diet (HPD, 26.3% protein) for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington's Disease Rating Scale (UHDRS). The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378) in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression.
[Specific control of gene expression by oligonucleotides: from chemistry to clinical aspects]. (1997)

Oligonucleotides can be synthesized for specific regulation of gene expression within the living cell. The oligonucleotide acts either on messenger RNA (nonsense and ribozyme strategies) or on DNA (triple helix or antigene strategy). This pharmacological approache requires chemically modified oligonucleotides and appropriate vectors. Applications in gene therapy can also be developed using a DNA vector to produce regulator RNA (nonsense, ribozyme, antigene) within the same cells. Early clinical trials are being conducted to determine the therapeutic efficacy of these two approaches.
Bacteriophage Resistance in Lactococcus lactis ssp. lactis Using Antisense Ribonucleic Acid (1992)

Antisense RNA against a conserved bacteriophage gene when expressed in a Lactococcus lactis ssp. lactis strain renders it resistant to bacteriophage infection. Two open reading frames have been identified in a L. lactis ssp. lactis bacteriophage that are conserved in a majority of isolates. They code for an 18-kDa (designated GP18C) protein and a 24-kDa (GP24C) protein, respectively, which are arranged along with previously identified open reading frames in a tandem motif similar to other bacteriophages. The presence of gp18C and gp24C in a number of bacteriophage isolates was confirmed by polymerase chain reaction using primers specific for these regions. Plasmids bearing various fragments of gp18C, gp24C, or both were constructed such that the respective open reading frames were positioned in the antisense direction relative to the Lactococcus lactis ssp. cremoris Wg2 promoter, p59. These antisense RNA-producing vectors inhibited the efficiency of plaquing of L. lactis ssp. lactis bacteriophage phi 7-9 up to 50%; the resulting plaques were extremely small and irregular in shape. The replication of the bacteriophage was severely inhibited, and the total number decreased over the first 3 h during infection in strains expressing antisense RNA compared with the host strain alone, in which the bacteriophage number increased 10(4)-fold.
New developments in biochemical mass spectrometry: electrospray ionization (1990)

The principles, development, and recent application of electrospray ionization-mass spectrometry (ESI-MS) to biological compounds are reviewed. ESI-MS methods now allow determination of accurate molecular weights for proteins extending to over 50,000, and in some cases well over 100,000. Similar capabilities are being developed for oligonucleotides. The instrumentation used for ESI-MS is briefly described and it is shown that, although ionization efficiency appears to be uniformly high, detector sensitivity may be directly correlated with molecular weight. The use of tandem mass spectrometry (e.g., MS/MS) for extending collision-induced dissociation (CID) methods to the structural studies of large molecules is described. For example, effective CID of various albumin species (molecular weight approximately 66,000) can be obtained, far larger than obtainable for singly charged molecular ions. The combination of capillary electrophoresis, in both free solution zone electrophoresis and isotachophoresis formats, as well as microcolumn liquid chromatography with ESI-MS, provides the capability for on-line separation and analysis of subpicomole quantities of proteins. These and other new developments related to ESI-MS are illustrated by a range of examples. Fundamental considerations suggest even more impressive developments may be anticipated related to detection sensitivity and methods for obtaining structural information.
Determination of Dextran with Anthrone (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Dextran with AnthroneT. A. Scott, Jr. and E. H. MelvinCite this: Anal. Chem. 1953, 25, 11, 1656–1661Publication Date (Print):November 17, 1953Publication History Published online1 May 2002Published inissue 17 November 1953https://pubs.acs.org/doi/10.1021/ac60083a023https://doi.org/10.1021/ac60083a023research-articleACS PublicationsRequest reuse permissionsArticle Views1779Altmetric-Citations900LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Eukaryotic Selenocysteine Incorporation Follows a Nonprocessive Mechanism That Competes with Translational Termination (2000)

The synthesis of eukaryotic selenoproteins involves the recoding of an internal UGA codon as a site for selenocysteine incorporation. This recoding event is directed by a selenocysteine insertion sequence in the 3'-untranslated region. Because UGA also functions as a signal for peptidyl-tRNA hydrolysis, we have investigated how the rates of translational termination and selenocysteine incorporation relate to cis-acting elements in the mRNA as well as to trans-acting factors in the cytoplasm. We used cis-elements from the phospholipid glutathione peroxidase gene as the basis for this work because of its relatively high efficiency of selenocysteine incorporation. The last two codons preceding the UGA were found to exert a far greater influence on selenocysteine incorporation than nucleotides downstream of it. The efficiency of selenocysteine incorporation was generally much less than 100% but could be partially enhanced by concomitant overexpression of the tRNA(Sec) gene. The combination of two or three UGA codons in one reading frame led to a dramatic reduction in the yield of full-length protein. It is therefore unlikely that multiple incorporations of selenocysteine are processive with respect to the mode of action of the ribosomal complex binding to the UGA site. These observations are discussed in terms of the mechanism of selenoprotein synthesis and its ability to compete with termination at UGA codons.
Claudins and paracellular transport: an update (2007)

These findings reveal tantalizing clues to claudin biology and function. Much remains unknown, however, and these findings will hopefully encourage further research in this important area.