gebhart/patrepeval huggingface dataset:
OBFS: A File System for Object-based Storage Devices (2004)

The object-based storage model, in which files are made up of one or more data objects stored on self-contained Object-Based Storage Devices (OSDs), is emerging as an architecture for distributed storage systems. The workload presented to the OSDs will be quite different from that of generalpurpose file systems, yet many distributed file systems employ general-purpose file systems as their underlying file system. We present OBFS, a small and highly efficient file system designed for use in OSDs. Our experiments show that our user-level implementation of OBFS outperforms Linux Ext2 and Ext3 by a factor of two or three, and while OBFS is 1/25 the size of XFS, it provides only slightly lower read performance and 10%--40% higher write performance.
Multiplexed Millimeter Wave Communication with Dual Orbital Angular Momentum (OAM) Mode Antennas (2015)

Communications using the orbital angular momentum (OAM) of radio waves have attracted much attention in recent years. In this paper, a novel millimeter-wave dual OAM mode antenna is cleverly designed, using which a 60 GHz wireless communication link with two separate OAM channels is experimentally demonstrated. The main body of the dual OAM antenna is a traveling-wave ring resonator using two feeding ports fed by a 90° hybrid coupler. A parabolic reflector is used to focus the beams. All the antenna components are fabricated by 3D printing technique and the electro-less copper plating surface treatment process. The performances of the antenna, such as S-parameters, near-fields, directivity, and isolation between the two OAM modes are measured. Experimental results show that this antenna can radiate two coaxially propagating OAM modes beams simultaneously. The multiplexing and de-multiplexing are easily realized in the antennas themselves. The two OAM mode channels have good isolation of more than 20 dB, thus ensuring the reliable transmission links at the same time.
The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues. (2013)

Gremlin 1 and noggin are inhibitors of bone morphogenetic protein (BMP) signaling. They are vital during early development but their role in adult tissues has remained largely unresolved. The BMP signaling pathway has also been implicated in tumorigenesis, however with emphasis on the role of the ligands and receptors. We performed a concurrent survey of gremlin 1 and noggin protein expression in multiple normal and cancer samples, using immunohistochemistry on tissue microarrays containing 96 samples from 34 different normal organs/tissue sites and 208 samples of 34 different tumor types. In majority of both normal and tumor samples, gremlin 1 and noggin expression was negative or weak. However, normal stomach and skin demonstrated distinct gremlin 1 and noggin expression indicating a role in adult tissues. Likewise, strong expression of both antagonists was detected in Leydig cells of testis. In the tumor panel, the expression patterns were more variable but elevated BMP antagonist expression was detected for the first time in few cases, such as glioblastoma, hepatocellular carcinoma and diffuse B-cell lymphoma for gremlin 1 and renal granular cell tumor and thyroid papillary carcinoma for noggin. Even though gremlin 1 and noggin were not widely expressed in adult tissues, in a subset of organs their expression pattern indicated a potential role in normal tissue homeostasis as well as in malignancies.
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. (1993)

Defects in neurotransmitter glutamate transport may be an important component of chronic neurotoxicity in diseases such as amyotrophic lateral sclerosis. There are no reliable models of slow glutamate neurotoxicity. Most previous in vitro systems have studied the rapid neurotoxic effects of direct-acting glutamate agonists. Therefore, we developed a model of slow toxicity in cultured organotypic spinal cord slices. The model was based on selective inhibition of glutamate transport, which continuously raised the concentration of glutamate in the culture medium. This resulted in the slow degeneration of motor neurons over several weeks. Motor neuron toxicity was selectively prevented by non-N-methyl-D-aspartate glutamate receptor antagonists and glutamate synthesis or release inhibitors but not by N-methyl-D-aspartate receptor antagonists. Thus, selective inhibition of glutamate transport produces a model of clinically relevant slow neurotoxicity and appears to be mediated by the action of non-N-methyl-D-aspartate receptors. This data supports the hypothesis that the slow loss of motor neurons in amyotrophic lateral sclerosis could be due, in part, to defective glutamate transport.
Construction of a Novel CHO Cell Line Coexpressing Human GlycosyItransferases and fusion PSGL-1-Immunoglobulin G (2006)

The CHO SSF3 cell line used as host for our DNA transfections has been previously adapted for growth in suspension cultures in serum-free media. The recombinant CHO SSF3 cells efficiently returned to growth in serum-free suspension culture after extended culture in monolayers using serum-supplemented media. This indicated that the preadapted cell phenotype was stable after transfection and selection of heterologous genes. Furthermore, the recombinant PSGL-1-lgG protein expressed by CHO SSF3 previously cotransfected with plasmids encoding both the N-acetyl-D-glucosaminyl-transferase and α1,3-fucosyltransferase presented a “human-like” glycosylation pattern, which was specifically recognized by anti-Lewisx antibodies. The recombinant PSGL-1 bound to P-selectin, its natural ligand, showing that it was properly glycosylated. The transfection of mammalian cell lines with plamids encoding human glycosyltransferases of defined specificity provides a tool to generate novel stable host cell lines for the production of recombinant proteins with tailored glycosylation pattern.
High-order multipolar hyperpolarizabilities with imaginary frequency for H and He (1996)

Calculations are reported of X3zz,zz,z,z(−iω;iω,0,0), X3zz,zz,x,x(−iω;iω,0,0), X3zzz,z,z,z(−iω;iω,0,0), X4zz,z,z,z,z(−iω;iω,0,0,0), and X4zz,x,x,z,z(−iω;iω,0,0,0) for H and He. These are the independent components of the atomic (quadrupole)2-(dipole)2, (octupole)-(dipole)3, and (quadrupole)-(dipole)4 hyperpolarizability tensors for an imaginary frequency iω. The first three quantities have been used for the determination of the R−8 dispersion contribution to the H-H, H-He, and He-He collision-induced pair polarizability functions. The last two quantities will be needed in future calculations of the leading order (R−7) dispersion contributions to the collision-induced first hyperpolarizability (β) for the H-He pair. The calculations were based on sum-over-states formulations with near-exact wave functions for H and highly accurate explicitly electron-correlated wave functions for He. For this reason we believe them to be of benchmark quality. © 1996 John Wiley & Sons, Inc.
Electrospinning and electrically forced jets. I. Stability theory (2001)

Electrospinning is a process in which solid fibers are produced from a polymeric fluid stream (solution or melt) delivered through a millimeter-scale nozzle. The solid fibers are notable for their very small diameters (&amp;lt;1 μm). Recent experiments demonstrate that an essential mechanism of electrospinning is a rapidly whipping fluid jet. This series of papers analyzes the mechanics of this whipping jet by studying the instability of an electrically forced fluid jet with increasing field strength. An asymptotic approximation of the equations of electrohydrodynamics is developed so that quantitative comparisons with experiments can be carried out. The approximation governs both long wavelength axisymmetric distortions of the jet, as well as long wavelength oscillations of the centerline of the jet. Three different instabilities are identified: the classical (axisymmetric) Rayleigh instability, and electric field induced axisymmetric and whipping instabilities. At increasing field strengths, the electrical instabilities are enhanced whereas the Rayleigh instability is suppressed. Which instability dominates depends strongly on the surface charge density and radius of the jet. The physical mechanisms for the instability are discussed in the various possible limits.
Experimental therapy of human glioma by means of a genetically engineered virus mutant (1991)

Malignant gliomas are the most common malignant brain tumors and are almost always fatal. A thymidine kinase-negative mutant of herpes simplex virus-1 (dlsptk) that is attenuated for neurovirulence was tested as a possible treatment for gliomas. In cell culture, dlsptk killed two long-term human glioma lines and three short-term human glioma cell populations. In nude mice with implanted subcutaneous and subrenal U87 human gliomas, intraneoplastic inoculation of dlsptk caused growth inhibition. In nude mice with intracranial U87 gliomas, intraneoplastic inoculation of dlsptk prolonged survival. Genetically engineered viruses such as dlsptk merit further evaluation as novel antineoplastic agents.
The Roots of Backpropagation: From Ordered Derivatives to Neural Networks and Political Forecasting (1994)

Scientists, engineers, statisticians, operations researchers, and other investigators involved in neural networks have long sought direct access to Paul Werbos's groundbreaking, much-cited 1974 Harvard doctoral thesis, The Roots of Backpropagation, which laid the foundation of backpropagation
Intraventricular Infusion of Apolipoprotein E Ameliorates Acute Neuronal Damage after Global Cerebral Ischemia in Mice (2000)

The ability of intraventricular infusion of apolipoprotein E (apoE) to reduce neuronal damage after global cerebral ischemia was investigated in apoE-deficient and wild-type mice. ApoE (5 microg/mL lipid-conjugated derived from human plasma; 1 microL/h, continuous infusion) significantly reduced neuronal damage in the caudate nucleus and CA2 pyramidal cell layer by approximately 50% in apoE-deficient mice after global ischemia compared to vehicle infusion. In wild-type mice infused with apoE, there was a trend for ischemic neuronal damage to be reduced. ApoE-infused mice had a marked reduction in 4-hydroxynonenal immunoreactivity, as a marker of lipid peroxidation. The results show that the presence of apoE at or after the time of injury can be neuroprotective, possibly via an anti-oxidant mechanism.
Effect of intravenous oxyfedrine on exercise in patients with ischaemic heart disease. (1991)

In a double blind crossover trial, acute effects of 8 mg intravenous oxyfedrine were compared with those of placebo in 18 patients with stable effort angina assessed by treadmill exercise testing. In the resting state, oxyfedrine caused an increase in heart rate (84 +/- 23 to 103 +/- 19 bpm, p less than 0.01), systolic blood pressure (123 +/- 16 to 133 +/- 20 mmHg, p less than 0.01) and double product (11 x 10(3) +/- 2 x 10(3) to 13.7 x 10(3) +/- 3.1 x 10(3), p less than 0.01) as compared to placebo. However, these parameters were not significantly different at the end of first or second stage of the treadmill test (p = NS). Time to one mm ST segment depression was increased with oxyfedrine as compared to placebo (1.5 +/- 1.5 to 1.9 +/- 1.5 minutes, p less than 0.05). Oxyfedrine did not increase the total duration of exercise (4.1 +/- 1.0 to 4.7 +/- 2.2 minutes, p = NS) or time to ischaemic symptoms (2.7 +/- 1.3 to 2.9 +/- 1.9 minutes, p = NS). The total work done was significantly more on oxyfedrine 312 +/- 189 joules/kg to 370 +/- 209 joules/kg, p less than 0.01) as also the double product achieved (20.6 x 10(3) +/- 6.1 x 10(3) to 22.5 x 10(3) +/- 6.4 x 10(3), p less than 0.01). It is concluded that intravenous oxyfedrine improves exercise capacity in patients with stable effort angina presumably by reducing myocardial ischaemia.
Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum (1990)

Acetoacetate decarboxylase (ADC) (EC4.1.1.4) of Clostridium acetobutylicum DSM 792 was purified to homogeneity, and its first 25 N-terminal amino acids were determined. Oligonucleotide probes deduced from this sequence were used to detect positive clones in partial gene banks derived from Sau3A and HaeIII digests with following ligation into the vector pUC9. In Escherichia coli, the 2.1-kbp HaeIII clones expressed high levels of ADC activity. The expression was independent of the orientation of the insert with respect to the lac promoter of the vector and also of the addition of isopropyl-beta-D-thiogalactopyranoside, thus indicating that sequences located on the clostridial DNA controlled transcription and translation. From the E. coli clone with the recombinant plasmid pUG93 containing the 2.1-kbp HaeIII fragment, the ADC protein was purified and compared with the native enzyme. Both were indistinguishable with respect to the molecular mass of subunits and native protein as well as to activity stain. The 2.9-kbp Sau3A fragment could be shown to contain the amino terminus of the acetoacetate decarboxylase (adc) gene but did not express enzyme activity. It partially overlapped with the HaeIII fragment, spanning together 4,053 bp of the clostridial genome that were completely sequenced. Four open reading frames (ORFs) could be detected, one of which was unambiguously assigned to the acetoacetate decarboxylase (adc) gene. Amino acid sequences of the N terminus and the catalytic center as deduced from the nucleotide sequence were identical to sequences obtained from direct analysis of the protein. Typical procaryotic transcriptional and translational start and stop signals could be found in the DNA sequence. Together with these regulatory sequences, the adc gene formed a single operon. The carboxyl terminus of the enzyme proved to be rather hydrophobic. In vitro transcription-translation assays resulted in formation of ADC and ORF3 gene product; the other two ORFs were not expressed. Whereas no homology of the adc gene and ORF2 could be detected with sequences available in the EMBL or GenBank data bases, the obviously truncated ORF1 showed significant similarity to alpha-amylase of Bacillus subtilis. The restriction pattern and N-terminal amino acid sequence (as deduced from the nucleotide sequence) of ORF3 proved to be identical to those of the large subunit of acetoacetyl coenzyme A:acetate/butyrate:coenzyme A transferase.
Prevention and Cure of Autoimmune Diabetes in Nonobese Diabetic Mice by Continuous Administration of FTY720 (2005)

FTY720, which does not cause generalized immunosuppression, may be a safe and benign therapeutic agent for chronic use to prevent or cure type 1 diabetes.
Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects (2016)

Obesity related hypertension is a major risk factor for resistant hypertension. We do not completely understand the mechanism(s) underlying the development of obesity related hypertension which hinders the development of novel treatment strategies for this condition. Data from experimental studies and small clinical trials indicate that transport of l-arginine, the substrate for nitric oxide (NO), and subsequent NO production are reduced in obesity induced hypertension. Reduced NO bioavailability can induce hypertension via multiple mechanisms. Mirmiran et al. recently analyzed data from a large population study and found that the association between dietary l-arginine and serum nitrate and nitrite was weakened in obese hypertensive subjects compared to obese normotensives. These data suggest that l-arginine dependent NO production is impaired in the former group compared to the latter which may represent a novel mechanism contributing to hypertension in the setting of obesity.
Travelling-wave optical amplifier at 1.3μm (1987)

We describe a travelling-wave optical amplifier operating at a wavelength near 1.3 μm. We demonstrate a fibre-amplifier-fibre gain of 131 dB with a gain variation of 13.1 dB. The fibre-amplifier coupling loss is 4.5 dB/interface and the amplifier facet mean reflectivity is 0.04%.
Hd3a, a Rice Ortholog of the Arabidopsis FT Gene, Promotes Transition to Flowering Downstream of Hd1 under Short-Day Conditions (2002)

Heading date 3a (Hd3a) has been detected as a heading-date-related quantitative trait locus in a cross between rice cultivars Nipponbare and Kasalath. A previous study revealed that the Kasalath allele of Hd3a promotes heading under short-day (SD) conditions. High-resolution linkage mapping located the Hd3a locus in a approximately 20-kb genomic region. In this region, we found a candidate gene that shows high similarity to the FLOWERING LOCUS T (FT) gene, which promotes flowering in Arabidopsis: Introduction of the gene caused an early-heading phenotype in rice. The transcript levels of Hd3a were increased under SD conditions. The rice Heading date 1 (Hd1) gene, a homolog of CONSTANS (CO), has been shown to promote heading under SD conditions. By expression analysis, we showed that the amount of Hd3a mRNA is up-regulated by Hd1 under SD conditions, suggesting that Hd3a promotes heading under the control of Hd1. These results indicate that Hd3a encodes a protein closely related to Arabidopsis FT and that the function and regulatory relationship with Hd1 and CO, respectively, of Hd3a and FT are conserved between rice (an SD plant) and Arabidopsis (a long-day plant).
Boosting and Differential Privacy (2010)

Boosting is a general method for improving the accuracy of learning algorithms. We use boosting to construct improved privacy-pre serving synopses of an input database. These are data structures that yield, for a given set Q of queries over an input database, reasonably accurate estimates of the responses to every query in Q, even when the number of queries is much larger than the number of rows in the database. Given a base synopsis generator that takes a distribution on Q and produces a "weak" synopsis that yields "good" answers for a majority of the weight in Q, our Boosting for Queries algorithm obtains a synopsis that is good for all of Q. We ensure privacy for the rows of the database, but the boosting is performed on the queries. We also provide the first synopsis generators for arbitrary sets of arbitrary low-sensitivity queries, i.e., queries whose answers do not vary much under the addition or deletion of a single row. In the execution of our algorithm certain tasks, each incurring some privacy loss, are performed many times. To analyze the cumulative privacy loss, we obtain an O(ε <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) bound on the expected privacy loss from a single e-differentially private mechanism. Combining this with evolution of confidence arguments from the literature, we get stronger bounds on the expected cumulative privacy loss due to multiple mechanisms, each of which provides e-differential privacy or one of its relaxations, and each of which operates on (potentially) different, adaptively chosen, databases.
Dynamic Energy Management In Cloud Data Centers: A Survey (2013)

Cloud data centers have become indispensable infrastructure for computing and data storage that facilitate the development of diversified services offered by the cloud. These data centers consume enormous amounts of electrical energy to process the cloud services resulting in large amount of CO 2 emissions, high operational cost, and affecting the lifetime of hardware equipments. This necessitates the development of efficient energy management techniques in cloud data centers for both economic and environmental standpoints. Energy management at data centers can be static or dynamic. Energy consumption can be reduced by employing dynamic energy management techniques both in hardware and software levels at cloud data centers. This paper surveys various issues related to dynamic energy management in cloud data centers.
Simple and efficient liposomal encapsulation of topotecan by ammonium sulfate gradient: stability, pharmacokinetic and therapeutic evaluation (2002)

Topotecan (TPT), a topoisomerase I inhibitor, is presently undergoing clinical evaluation worldwide. Previous studies have shown that entrapping TPT within multi-lamellar vesicle liposome can stabilize the lactone moiety, which is structurally important for biological activity. However, low drug:lipid ratios due to the amphipathic character and small entrapment volume in the unilamellar vesicle limits the development of pharmaceutically acceptable liposomal formulation. With an aim to improve on this drawback, we herein describe a method that utilizes the ammonium sulfate gradient to entrap TPT into liposomes. By this method, the encapsulation efficiency was over 90% and a drug:lipid molar ratio as high as 1:5.4 was reached. In comparison with free drug, liposome-encapsulated TPT is more stable in physiological conditions and shows higher in vitro cytotoxicity. Because of increased blood circulation time, the initial plasma concentration and area under the plasma concentration of liposomal drugs were 14 and 40 times, respectively, of those of free drug. Furthermore, liposome encapsulation enhanced the antitumor activity of TPT in syngeneic murine C-26 and human HTB-9 xenograft models in vivo. At a dose of 5 mg/kg, the tumor growth delay of liposomal formulation was significantly than that of free TPT. Based on these results, we believe that this liposomal TPT formulation is worthy of further clinical study.
Epidemic of adenovirus‐induced respiratory illness among US military recruits: Epidemiologic and immunologic risk factors in healthy, young adults*† (2001)

Adenovirus (Ad)-induced acute respiratory illnesses resurged among civilian adults and selected military training populations in the United States during the late 1990s. We examined the epidemiologic and immunologic correlates of Ad-induced respiratory illnesses during a large outbreak at an Army basic training installation in southeast United States during a 9-day period in November 1997. A total of 79 recruits hospitalized with acute respiratory illnesses were evaluated during the outbreak period; confirmation of Ad infection by isolation of Ad-like cytopathic agents from throat cultures was detected in 71 (90%) of these patients. Serotyping of 19 (27%) of these 71 isolates identified the etiologic agent to be Ad type 4 (Ad4). In addition, 30 (81%) of 37 patients in whom paired sera were collected demonstrated significant increases (i.e., 4-fold or higher) in serum anti-Ad4 neutralizing antibodies. Anti-Ad4 immunity in new recruits was found to be very low (15 to 22%). A case-control study involving 66 of the 79 hospitalized cases and 189 non-ill controls from the same units was conducted. A lower risk of hospitalization for acute respiratory illnesses was documented for female recruits (odds ratio[OR] = 0.47, P <.05) whereas, a higher risk was noted for smokers (OR = 1.89, P <.05). Unit (training company) attack rates as high as 8 to 10% per week were documented and the outbreak quickly subsided after live, oral Ad types 4 and 7 vaccination was resumed in November 1997. Re-establishment of a military Ad vaccination program is critical for control of Ad-induced acute respiratory illnesses.
Compression Artifacts Removal Using Convolutional Neural Networks (2016)

This paper shows that it is possible to train large and deep convolutional neural networks (CNN) for JPEG compression artifacts reduction, and that such networks can provide significantly better reconstruction quality compared to previously used smaller networks as well as to any other state-of-the-art methods. We were able to train networks with 8 layers in a single step and in relatively short time by combining residual learning, skip architecture, and symmetric weight initialization. We provide further insights into convolution networks for JPEG artifact reduction by evaluating three different objectives, generalization with respect to training dataset size, and generalization with respect to JPEG quality level.