gebhart/patrepeval huggingface dataset:
Efficacy and tolerability of an investigational nitric oxide–releasing topical gel in patients with molluscum contagiosum: A randomized clinical trial (2019)

Of the doses studied, SB206 12% applied once daily provided the best balance between MC lesion clearance and tolerability for evaluation in a larger study.
Active Profiling of Physical Devices at Internet Scale (2016)

Nowadays, more and more physical devices embed computing and networking capabilities and are visible on the Internet. These devices include webcams, net-printers, and industrial control equipments, etc. Collecting information about these devices is crucial to preserve cyber-security and facilitate security auditing for system administrators. In this paper, we propose a scalable framework for physical device profiling. It leverages banner grabbing to identify device types and running services, and uses clock skew to determine a device ID. Our framework scales well. We implement a prototype system and use it to profile Webcams and industrial control device. The results show that our system can effectively profile and identify Webcams in real time. We deploy it on the cloud server and use it to detect 4 billion IP addresses to profile 1.2 million Webcams and more than 60 thousand industrial control devices in 20 hours.
Nanopore DNA sensors in CMOS with on-chip low-noise preamplifiers (2011)

We present an integrated platform for single-molecule electrochemical analysis in which solid-state nanopore sensors are post-fabricated into a custom CMOS preamplifier die. The usable bandwidth of solid-state nanopore sensors is typically constrained by noise caused by parasitic impedances from the sensor's support substrate and external measurement electronics. By integrating the sensor with a dedicated amplifier we provide a path to significantly reduce these parasitics. The new system includes a low-noise 8-channel preamplifier in a 0.13μm CMOS process. The chip is post-processed to fabricate Ag/AgCl microelectrodes and silicon nitride nanopores.
Episodic Dural Stimulation in Awake Rats: A Model for Recurrent Headache (2007)

Repeated IS stimulation of the dura produces a chronic state of trigeminal hypersensitivity and potentiates the response to GTN. This hyperresponsiveness outlasts the last IS infusion and is the basis of our rat model of recurrent headache. This model can be used to study the changes in the brain and periphery induced by repeated trigeminovascular nociceptor activation and has the potential to elucidate the mechanisms for the transition of episodic to chronic headache.
AV blocking due to asynchronous vagal stimulation in rats (2000)

The parasympathetic nervous system innervates the heart through two cervical vagal branches. The right vagal branch mainly influences the heart rate by the modulation of the rhythmogenesis of the sinoatrial node. The left branch predominantly influences the conduction properties of the atrioventricular (AV) node. We investigated the effect of asynchronous stimulation by the vagal nerves on the occurrence of irregularities in heart rate. In rats, the vagal nerves were isolated and cut. Different vagal stimulation patterns (continuous, pulsed) were applied. The heart was beating spontaneously under continuous vagal stimulation. In case of pulsed vagal stimulation, the atria were paced at different rates. Asynchronicity was induced by delaying the right stimulus with respect to the left stimulus (early right) or the left stimulus with respect to the right stimulus (early left). The value of the fraction of deviated R-R or P-Q intervals in the distribution in the histogram was used to characterize irregularities during a stimulation protocol (duration in case of continuous stimulation: 20 s; pulsed stimulation: 120 s). Under both stimulation patterns (continuous or pulsed), we found that early left vagal stimulation introduced a much larger fraction of deviated intervals in the R-R or P-Q histogram (in R-R: 29.1 +/- 4.9%; in P-Q: 12.90 +/- 1.95%) than early right vagal stimulation (in R-R: 7.4 +/- 2.0%; in P-Q: 1. 05 +/- 0.50%) or synchronous stimulation (in R-R: 8.2 +/- 3.6%; in P-Q: 2.15 +/- 0.75%). We conclude that early stimulation by the left vagal nerve can introduce irregularities in heart rate, mainly due to different degrees of AV nodal blockade.
A high‐resolution analysis of chromatin structure along p53 sequences (1996)

A detailed investigation of how nucleosomes are formed and arranged on the DNA sequence is a prerequisite to understanding the molecular mechanisms of DNA-dependent processes such as transcription, replication, DNA repair, and mutagenesis. In this report we analyzed the chromatin structure of exons 5–8 of the p53 gene in human fibroblasts. We mapped at the nucleotide level the positions of DNase I and micrococcal nuclease cleavage sites in permeabilized cells. Areas of clear DNase I protection, which would be indicative of the binding of sequence-specific proteins, were not detected. Instead, the micrococcal nuclease and DNase digestion patterns suggested that this region was covered by nucleosomes and that two areas spanning exons 5 and 6 are occupied preferentially. These nucleosomes could influence DNA damage distribution, repair of certain lesions, and other aspects of the mutagenesis process in p53 sequences. © 1996 Wiley-Liss, Inc.
Brain Activity Changes Associated With Treadmill Training After Stroke (2009)

Despite the strong subcortical contributions to gait control, rehabilitation-associated walking improvements are associated with cortical activation changes. This is similar to findings in upper limb rehabilitation with some differences in the involved cortical areas. We observed bihemispheric activation increases with greater recovery both in cortical and subcortical regions with movement of the paretic foot. However, although the dorsal premotor cortex appears to play an important role in recovery of hand movements, evidence for the involvement of this region in lower extremity recovery was not found.
Task constraints in visual working memory (1998)

This paper examines the nature of visual representations that direct ongoing performance in sensorimotor tasks. Performance of such natural tasks requires relating visual information from different gaze positions. To explore this we used the technique of making task relevant display changes during saccadic eye movements. Subjects copied a pattern of colored blocks on a computer monitor, using the mouse to drag the blocks across the screen. Eye position was monitored using a dual-purkinje eye tracker, and the color of blocks in the pattern was changed at different points in task performance. When the target of the saccade changed color during the saccade, the duration of fixations on the model pattern increased, depending on the point in the task that the change was made. Thus different fixations on the same visual stimulus served a different purpose. The results also indicated that the visual information that is retained across successive fixations depends on moment by moment task demands. This is consistent with previous suggestions that visual representations are limited and task dependent. Changes in blocks in addition to the saccade target led to greater increases in fixation duration. This indicated that some global aspect of the pattern was retained across different fixations. Fixation durations revealed effects of the display changes that were not revealed in perceptual report. This can be understood by distinguishing between processes that operate at different levels of description and different time scales. Our conscious experience of the world may reflect events over a longer time scale than those underlying the substructure of the perceptuo-motor machinery.
Influence of a superactivated charcoal on the toxic effects of aflatoxin or T-2 toxin in growing broilers (1997)

To evaluate the effectiveness of a superactivated charcoal (SAC) in alleviating mycotoxicosis, two experiments were conducted in which 432 male broiler chicks (216 per experiment) were fed diets containing 4 mg aflatoxin (AF) or 6 mg T-2 toxin/kg of diet, with and without 0.5% SAC, from 1 to 21 d of age. Feeding AF and T-2 toxin significantly decreased BW gain over the 21-d experimental period. Inclusion of SAC in the diet containing AF resulted in BW gains that were intermediate between gains of chicks fed AF and those of controls. No benefits were seen in BW gain when SAC + T-2 toxin was fed. Feeding AF increased relative weights of liver, spleen, and kidney; however, only liver weight in Experiment 1 was similar to controls when SAC was included. Of the blood parameters altered by AF (decreased cholesterol, inorganic phosphorus, total protein, and urea nitrogen, and increased mean corpuscular volume and hematocrit in Experiment 1; decreased albumin and total protein, and increased creatine kinase in Experiment 2) only urea nitrogen, hematocrit, and inorganic phosphorus (Experiment 1) and hematocrit (Experiment 2) were comparable to controls when SAC was included in the diet. Feeding T-2 toxin decreased serum cholesterol, total protein, urea nitrogen, and mean corpuscular volume; however, only cholesterol and mean corpuscular volume were improved with the addition of SAC (Experiment 1). Oral lesions were observed in birds fed T-2 toxin with no difference in severity when SAC was added in Experiment 1, however in Experiment 2, birds fed SAC + T-2 had a significantly lower lesion scores than those fed T-2 alone. Mortality was noted in both experiments but was not influenced by SAC treatment. These findings suggest that the addition of dietary SAC is marginally effective in alleviating some of the toxic affects associated with AF, but was of little benefit when T-2 toxin was fed to growing broiler chicks.
SH3 Domain-mediated Interaction of Dystroglycan and Grb2 (1995)

Dystroglycan is a novel laminin receptor that links the extracellular matrix and sarcolemma in skeletal muscle. The dystroglycan complex containing alpha- and beta-dystroglycan also serves as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. beta-Dystroglycan has now been expressed in vitro and shown to directly interact with Grb2, an adapter protein involved in signal transduction and cytoskeletal organization. Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem-5, demonstrated that the dystroglycan-Grb2 association is through beta-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains. Affinity chromatography has also shown endogenous skeletal muscle Grb2 interacts with beta-dystroglycan. Immunoprecipitation experiments have demonstrated that Grb2 associates with alpha/beta-dystroglycan in vivo in both skeletal muscle and brain. The specific dystroglycan-Grb2 interaction may play an important role in extracellular matrix-mediated signal transduction and/or cytoskeleton organization in skeletal muscle that may be essential for muscle cell viability.
Lovastatin Decreases the Receptor-Mediated Degradation of Acetylated and Oxidized LDLs in Human Blood Monocytes During the Early Stage of Differentiation Into Macrophages (1999)

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are used therapeutically to upregulate the LDL receptor-mediated removal of plasma cholesterol by the liver. Several lines of evidence indicate that these drugs also exert direct effects on the metabolism of native and modified LDL in extrahepatic cells. We studied the effects of lovastatin (LOV) on the degradation of native, acetylated, and oxidized LDL, and on levels of mRNA encoding for the LDL, types I and II class A macrophage scavenger, and CD36 receptors in human blood monocytes at different stages of their maturation into adherent macrophages. LOV (10 micromol/L) reduced the degradation of acetylated LDL when added to freshly isolated cells cultured for 2 (81+/-4% of control, P<0.05) and 5 (76+/-6%, of control, P<0.05) days. The degradation of oxidized LDL was also reduced in cells treated with LOV for 2 days after seeding (51+/-3% of control, P<0. 001) but not in 5-day-old cells. LOV had no significant effect on the degradation of either acetylated or oxidized LDL when added to fully matured macrophages allowed to differentiate under control conditions for 7 days before incubations with 10 micromol/L LOV for an additional 2 days. In contrast, LOV increased the degradation of native LDL in these cells at all 3 stages of cell differentiation. LOV also reduced class A types I and II macrophage scavenger receptor and CD36 mRNA levels in 2- and 5-day-old cells but not in the more mature macrophages. These data suggest that 3-hydroxy-3-methylglutaryl-coenzyme A inhibitors may reduce the expression and function of the class A types I and II macrophage scavenger receptor and CD36 in monocytes, during the early stages of their differentiation into adherent macrophages. These effects, if operative in vivo, may slow down the development of the atherosclerotic plaque and thus contribute to the beneficial effects of these drugs.
Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. (1996)

The catalytic, or third domain of Pseudomonas exotoxin A (PEIII) catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, inhibiting protein synthesis. We have determined the structure of PEIII crystallized in the presence of NAD to define the site of binding and mechanism of activation. However, NAD undergoes a slow hydrolysis and the crystal structure revealed only the hydrolysis products, AMP and nicotinamide, bound to the enzyme. To better define the site of NAD binding, we have now crystallized PEIII in the presence of a less hydrolyzable NAD analog, beta-methylene-thiazole-4-carboxamide adenine dinucleotide (beta-TAD), and refined the complex structure at 2.3 angstroms resolution. There are two independent molecules of PEIII in the crystal, and the conformations of beta-TAD show some differences in the two binding sites. The beta-TAD attached to molecule 2 appears to have been hydrolyzed between the pyrophosphate and the nicotinamide ribose. However molecule 1 binds to an intact beta-TAD and has no crystal packing contacts in the vicinity of the binding site, so that the observed conformation and interaction with the PEIII most likely resembles that of NAD bound to PEIII in solution. We have compared this complex with the catalytic domains of diphtheria toxin, heat labile enterotoxin, and pertussis toxin, all three of which it closely resembles.
PAIN SCORES AND SIDE EFFECTS IN RESPONSE TO LOW LEVEL LASER THERAPY (LLLT) FOR MYOFASCIAL TRIGGER POINTS. (1997)

Clinically, Low Level Laser Therapy - LLLT has been used successfully in the treatment of chronic pain but many have questioned the scientific basis for its use. Many studies have been poorly designed or poorly controlled. A double-blind, placebo-controlled, random-allocation study was designed to analyse the effect of second daily infrared (IR) laser (820 nm, 25 mW) and visible red laser (670 nm, 10 mw) at 1 J/cm2 and 5 J/cm2 on chronic pain. Forty-one consenting subjects with chronic pain conditions exhibiting myofascial trigger points in the neck and upper trunk region underwent five treatment sessions over a two week period. To assess progress, pain scores were measured using visual analogue scales before and after each treatment. The incidence of side effects was recorded. AII groups demonstrated significant reductions in pain over the duration of the study with those groups which received infrared (820 nm) laser at 1 J/cm2 and 5 J/cm2. demonstrating the most significant effects (p ‹ 0.001). Only those subjects who had active laser treatment experienced side effects. Results indicated that responses to LLLT at the parameters used in this study are subject to placebo and may be dependent on power output, dose and/or wavelength.
How to Upgrade 1500 Workstations on Saturday, and Still Have Time to Mow the Yard on Sunday (1995)

Imagine: It's Saturday afternoon. You run a script, watch it for a while, then go home. When you come back the next day, 1500 workstations and fileservers have new operating systems installed, complete with all your local customizations, with the user data on each one undisturbed and without leaving your office. On December 17, 1994, we did just that.

This paper will describe the infrastructure that allows us to perform completely automated updates of a large distributed network of HP UNIX computers. First, we will describe the policies we designed for distributed systems administration. Next, we will describe the tools which we developed or collected to implement these policies, and we will describe how to put it all together to do an upgrade. Throughout we will explain the philosophy behind it all and how our particular implementation could be generalized to other sites. Finally, we will describe some of the lessons learned along the way.
The fundamentals of metal combustion in composite explosives revealed by high speed microphotography (1989)

The antiplasmodium assay-guided investigation of the roots, stem bark, and leaves of <i>Persea americana</i> Mill. led to the isolation of a new fatty alcohol, perseatriol (<b>1</b>), along with six known compounds (<b>2-7</b>). Their structures were elucidated based on the analysis of their NMR and MS data. All crude extracts and fractions exhibited good antiplasmodial activity on <i>Plasmoduim falciparum</i> 3D7 with IC<sub>50</sub> values ranging from 0.76 to 10.5 μg/mL; they also displayed cytotoxicity against HeLa cells with low selectivity indexes (SIs). A preliminary <i>Plasmodium</i> lactate dehydrogenase (pLDH) assay was also performed on the isolated compounds. 9,9'-Di-<i>O</i>-feruloyl-5,5'-dimethoxysecoisolariciresinol (<b>4</b>) turned out to be non-toxic and displayed the best activities on <i>P. falciparum</i> with an IC<sub>50</sub> value of 0.05 μM, comparable to the reference drug chloroquine with an IC<sub>50</sub> value of 0.03 μM. Furthermore, besides compound <b>4</b>, this work reports the first isolation of lutein (<b>2</b>) and scopoletin (<b>3</b>) from <i>P. americana</i>. The crude extracts of roots, stem bark, and leaves of <i>P. americana</i>, their fractions and compounds completely suppressed the growth of <i>P. falciparum</i>. The observed activity supports the use of <i>P. americana</i> in folk medicine for the treatment of malaria.
Phage viability in organic media: insights into phage stability (1998)

The stability of the filamentous phages derived from phagemid pG8H6 has been examined in a range of solvents and solvent mixtures. The results show an enhanced capacity to infect E. coli after exposure to various organic solvent-water mixtures. The dependence of stability upon solvent hydrophobicity was demonstrated. Furthermore, conditions have been identified which should allow the application of phage display libraries based upon pG8H6 in organic media.
A GUIDE FOR APPROPRIATING ITIL V3 GOOD PRACTICES IN SME:LABORATORIOS MEREY CASE STUDY (2009)

Small and medium-sized enterprises (SME) are the main
					development engine of economy, particularly in countries in
					development, as is the case in Colombia. To be competitive, SME
					must use tested frameworks in its productive and support processes.
					In this paper we present a proposal we develop to help
					appropriation process of Information Technology Infrastructure
					Library (ITIL) good practices in SME in a successful way. We also
					present the proposal application in Laboratorios Merey Ltda., a
					Colombian medium enterprise, and this experience results.
Multiple-access capacity in mobile user satellite systems (1995)

The channel capacity of a satellite direct sequence CDMA system is analyzed including the effects of faded user interference, overlapping antenna beams, imperfect equalization of the antenna pattern across an antenna cell, and diversity reception. Simplified models are used to describe the impact of these effects on the channel capacity of single and multiple cofrequency CDMA systems. In a comparison of the uplink and downlink paths, the uplink of the CDMA system is shown to limit the channel capacity because the downlink can utilize code-orthogonality and coherent demodulation. In a multiple system comparison between band-shared CDMA and band-segmented FDMA/TDMA technologies, FDMA/TDMA is shown to provide about the same capacity for uniformly distributed traffic conditions over many cells and dramatically better capacity when traffic is concentrated in one cell. Due to the peak nature of telephony, this result supports the use of band-segmented systems in mobile user satellite systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin. (1980)

Highly specific antibodies (affinity-purified or hybridoma) directed against cell surface immunoglobulins on normal or neoplastic murine B lymphocytes were covalently coupled to the A chain of the plant toxin ricin. Such conjugates containing antibodies specific for IgM, for either of the two allotypes of IgD, or for the idiotype of the B cell tumor BCL1 rapidly bound in vitro to cells expressing the corresponding surface antigen and inhibited protein synthesis in such cells. The results demonstrate that A chain-coupled anti-idiotype antibody may be useful as a tumor-specific cytotoxic agent.
Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method (2004)

To identify differentially expressed genes in human HCC in China, we applied a modified SSH method for cDNA subtraction. Such modification has made the method more effective for subtraction. We have obtained 36 and 24 differentially expressed cDNA fragments after modified SSH from 4 paired samples of human HCC and non-HCC tissues, respectively. Reverse Northern blotting analysis was performed to further identify the genes differentially expressed in the HCC and non-HCC tissue samples. There were 25 genes really overexpressed in HCC, and their corresponding encoding molecules may reflect the events of cell accelerated metabolism, proliferation, angiogenesis, anti-apoptosis, tumorigenesis (TLH107, TFH9) and the potential for metastasis. Of the 25 genes overexpressed in HCC, 5 were novel and their full-length cDNAs were cloned. These 5 novel genes are functionally associated with the occurrence and development of HCC according to the Database analysis. In the paired non-HCC tissues, there were 15 genes lowly or not expressed in HCC, and their encoding proteins function as tumor suppressors (TFA3, TFA11), acute-phase reactive proteins, and the blood plasma proteins that are mainly or exclusively synthesized in the liver. The distinct profiles of the differentially expressed genes in HCC and the paired non-HCC tissues have partially reflected the genetic alterations during HCC tumorigenesis. The novel HCC-specific gene TLH6 and the CT antigen encoding gene TLH107 may have diagnostic and therapeutic potentials in HCC and/or other solid cancers.