gebhart/patrepeval huggingface dataset:
歌坛《狮子王》：爱如《风中之烛》 (2001)

2000年7月27日，伦敦海德公园上空，响彻云霄的掌声和欢呼声里，一个深情而富有磁性的歌声让人荡气回肠，一位摇滚巨星的最新个人演唱会正在此举行，而那动人的旋律，想必整个世界都不会陌生：这首《今夜你能否感应我的爱》(Can You Feel My Love Tonight)曾作为迪斯尼动画巨片《狮子王》主题曲获得了奥斯卡最佳歌曲奖。
Probing the mer- to fac-Isomerization of Tris-Cyclometallated Homo- and Heteroleptic (C,N)3 Iridium(III) Complexes (2008)

We have developed techniques which allow for covalent tethering, via a "hetero" cyclometallating ligand, of heteroleptic tris-cyclometallated iridium(III) complexes to polymeric supports (for application in light-emitting diode technologies). This involved the selective synthesis and thorough characterization of heteroleptic [Ir(C,N) 2(C',N')] tris-cyclometallated iridium(III) complexes. Furthermore, the synthesis and characterization of heteroleptic [Ir(C,N) 2OR] complexes is presented. Under standard thermal conditions for the synthesis of the facial ( fac) isomer of tris-cyclometallated complexes, it was not possible to synthesize pure heteroleptic complexes of the form [Ir(C,N) 2(C',N')]. Instead, a mixture of homo- and heteroleptic complexes was acquired. It was found that a stepwise procedure involving the synthesis of a pure meridonial ( mer) isomer followed by photochemical isomerization of this mer to the fac isomer was necessary to synthesize pure fac-[Ir(C,N) 2(C',N')] complexes. Under thermal isomerization conditions, the conversion of mer-[Ir(C,N) 2(C',N')] to fac-[Ir(C,N) 2(C',N')] was also not a clean reaction, with again a mixture of homo- and heteroleptic complexes acquired. An investigation into the thermal mer to fac isomerization of both homo- and heteroleptic tris-cyclometallated complexes is presented. It was found that the process is an alcohol-catalyzed reaction with the formation of an iridium alkoxide [Ir(C,N) 2OR] intermediate in the isomerization process. This catalyzed reaction can be carried out between 50 and 100 degrees C, the first such example of low-temperature mer-fac thermal isomerization. We have synthesized analogous complexes and have shown that they do indeed react so as to give fac-tris-cyclometallated products. A detailed explanation of the intermediates (and all of their stereoisomers, in particular when systems of the generic formula [M(a,b) 2(a',b')] are synthesized) formed in the mer to fac isomerization process is presented, including how the formed intermediates react further, and the stereoisomeric products they yield.
Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. (2002)

We have reported previously that sigma-2 receptors are expressed in high densities in a variety of tumor cell types (B. J. Vilner et al., Cancer Res., 55: 408-413, 1995) and that various sigma ligands have cytotoxic effects (B. J. Vilner et al., J. Neurosci., 15: 117-134, 1995). Other investigators have demonstrated increased expression of sigma-2 receptors in rapidly proliferating tumors (R. H. Mach et al., Cancer Res., 57: 156-161, 1997) and the ability of some sigma ligands to inhibit proliferation (P. J. Brent and G. T. Pang, Eur. J. Pharmacol., 278: 151-160, 1995). We demonstrate here the ability of sigma-2 receptor agonists to induce cell death by a mechanism consistent with apoptosis. In breast tumor cell lines that are sensitive (MCF-7) and resistant (MCF-7/Adr-, T47D, and SKBr3) to antineoplastic agents, incubation with the sigma-2 subtype-selective agonists CB-64D and CB-184 produced dose-dependent cytotoxicity (measured by lactate dehydrogenase release into medium). The EC(50) for this response was similar across cell lines, irrespective of p53 genotype and drug-resistance phenotype. CB-64D and the subtype nonselective sigma-2 agonists haloperidol and reduced haloperidol induced terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining in MCF-7 and T47D cells, indicating that cell death occurs via apoptosis. Apoptosis was also indicated by increases in Annexin V binding caused by CB-64D. In MCF-7 cells, cytotoxicity and Annexin V binding induced by the antineoplastics doxorubicin and actinomycin D was partially or completely abrogated by certain specific and general inhibitors of caspases. In contrast, caspase inhibitors had no effect on sigma-2 receptor-mediated (CB-64D and CB-184) cytotoxicity or Annexin V binding. Marked potentiation of cytotoxicity was observed when a subtoxic dose of CB-184 was combined with doxorubicin or actinomycin D, both in drug-sensitive (MCF-7) and drug-resistant (MCF-7/Adr-) cell lines. Haloperidol potentiated doxorubicin only in drug-resistant cells. These findings suggest the involvement of a novel p53- and caspase-independent apoptotic pathway used by sigma-2 receptors, which is distinct from mechanisms used by some DNA-damaging, antineoplastic agents and other apoptotic stimuli. These observations further suggest that sigma-2 receptors may be targets that can be therapeutically exploited in the treatment of both drug-sensitive and drug-resistant metastatic tumors.
Determination of Menstrual Blood Loss (1964)

There is a need for a simple and reliable method of measuring menstrual blood loss. Such measurements could be useful in clinical practice and in basic studies. A simple chemical method for quantifying blood loss is described. The method involves extracting tampons and towels used in blood collection for 20 hours with a sodium hydroxide solution. This method which has been used for 2 years is thought to be accurate and convenient. The method should be useful in determining the cause of iron deficiency anemia and for studies on the effect of various treatments on excessive menstrual bleeding.
Immune Modulation by Chemotherapy or Immunotherapy to Enhance Cancer Vaccines (2011)

Chemotherapy has been a mainstay in cancer treatment for many years. Despite some success, the cure rate with chemotherapy remains unsatisfactory in some types of cancers, and severe side effects from these treatments are a concern. Recently, understanding of the dynamic interplay between the tumor and immune system has led to the development of novel immunotherapies, including cancer vaccines. Cancer vaccines have many advantageous features, but their use has been hampered by poor immunogenicity. Many developments have increased their potency in pre-clinical models, but cancer vaccines continue to have a poor clinical track record. In part, this could be due to an inability to effectively overcome tumor-induced immune suppression. It had been generally assumed that immune-stimulatory cancer vaccines could not be used in combination with immunosuppressive chemotherapies, but recent evidence has challenged this dogma. Chemotherapies could be used to condition the immune system and tumor to create an environment where cancer vaccines have a better chance of success. Other types of immunotherapies could also be used to modulate the immune system. This review will discuss how immune modulation by chemotherapy or immunotherapy could be used to bolster the effects of cancer vaccines and discuss the advantages and disadvantages of these treatments.
Nanoscale contact electrodes for significant radiation power enhancement in photoconductive terahertz emitters (2013)

We present a photoconductive terahertz emitter that incorporates nanoscale plasmonic contact electrodes to offer significantly higher radiation powers compared to conventional photoconductive terahertz emitters. Radiation enhancement is the result of reducing the average transport path of photogenerated carriers to the plasmonic contact electrodes and, thus, increasing the number of the photocarriers that can be routed to the terahertz antenna in a sub-picosecond time-scale to efficiently contribute to terahertz radiation. We experimentally demonstrate up to 50 times higher terahertz radiation powers from the presented plasmonic photoconductive terahertz emitter compared to a similar conventional photoconductive terahertz emitter without plasmonic contact electrodes.
Oxprenolol and propranolol in anxiety states. A double-blind comparative study. (1976)

The efficacy of oxprenolol (Trasicor) and propranolol in controlling anxiety was compared in a double-blind study of patients with anxiety and tension. Efficacy was assessed by the investigator with the aid of a psychiatric rating scale consisting of 19 items, bythe patients using visual analogue scales, and by the investigator's and the patients' over-all assessments. Tolerance to the drugs was evaluated by over-all assessment and by means of a checklist of signs and symptoms which emerged during treatment. Little difference in the efficacy of the two drugs was observed. Both were effective in the treatment of anxiety and tension. In general, oxprenolol was significantly better tolerated than propranolol. Evidence of the intrinsic sympathomimetic activity of oxprenolol emerged during the course of the study or, alternatively, evidence that propranolol had a greater cardiac-depressant effect.
RD-OPT: an efficient algorithm for optimizing DCT quantization tables (2002)

The Discrete Cosine Transform (DCT) is widely used in lossy image and video compression schemes such as JPEG and MPEG. In this paper we describe RD-OPT, an efficient algorithm for constructing DCT quantization tables with optimal rate-distortion tradeoffs for a given image. The algorithm uses DCT coefficient distribution statistics in a novel way and uses a dynamic programming strategy to produce optimal quantization tables over a wide range of rates and distortions. It can be used to compress images at any desired signal-to-noise ratio or compressed size.
Wrist rehabilitation in chronic stroke patients by means of adaptive, progressive robot-aided therapy (2013)

Despite distal arm impairment after brain injury is an extremely disabling consequence of neurological damage, most studies on robotic therapy are mainly focused on recovery of proximal upper limb motor functions, routing the major efforts in rehabilitation to shoulder and elbow joints. In the present study we developed a novel therapeutic protocol aimed at restoring wrist functionality in chronic stroke patients. A haptic three DoFs (degrees of freedom) robot has been used to quantify motor impairment and assist wrist and forearm articular movements: flexion/extension (FE), abduction/adduction (AA), pronation/supination (PS). This preliminary study involved nine stroke patients, from a mild to severe level of impairment. Therapy consisted in ten 1-hour sessions over a period of five weeks. The novelty of the approach was the adaptive control scheme which trained wrist movements with slow oscillatory patterns of small amplitude and progressively increasing bias, in order to maximize the recovery of the active range of motion. The primary outcome was a change in the active RoM (range of motion) for each DoF and a change of motor function, as measured by the Fugl-Meyer assessment of arm physical performance after stroke (FMA). The secondary outcome was the score on the Wolf Motor Function Test (WOLF). The FMA score reported a significant improvement (average of 9.33±1.89 points), revealing a reduction of the upper extremity motor impairment over the sessions; moreover, a detailed component analysis of the score hinted at some degree of motor recovery transfer from the distal, trained parts of the arm to the proximal untrained parts. WOLF showed an improvement of 8.31±2.77 points, highlighting an increase in functional capability for the whole arm. The active RoM displayed a remarkable improvement. Moreover, a three-months follow up assessment reported long lasting benefits in both distal and proximal arm functionalities. The experimental results of th- s preliminary clinical study provide enough empirical evidence for introducing the novel progressive, adaptive, gentle robotic assistance of wrist movements in the clinical practice, consolidating the evaluation of its efficacy by means of a controlled clinical trial.
Transient, nonlethal expression of genes in vertebrate cells by recombinant entomopoxviruses (1997)

The group B entomopoxvirus (EPV) from Amsacta moorei (AmEPV) productively infects only insect cells. A series of AmEPV-lacZ recombinants was constructed in which the lacZ gene was regulated by either late (the AmEPV spheroidin or the cowpox virus A-type inclusion [ATI]) or early (the AmEPV esp [early strong promoter; derived from a 42-kDa AmEPV protein] or the Melolontha melolontha EPV fusolin, fus) virus promoters. When the AmEPV recombinants were used to infect vertebrate cells, beta-galactosidase expression occurred (in >30% of the cells) when lacZ was regulated by either the fus or esp early promoters but not when lacZ was regulated by the late promoters (spheroidin or ATI). Therefore, AmEPV enters vertebrate cells and undergoes at least a partial uncoating and early, but not late, viral genes are expressed. Neither viral DNA synthesis nor cytopathic effects were observed under any infection conditions. When an AmEPV recombinant virus containing the Aequorea victoria green fluorescent protein gene (gfp) under the control of the esp promoter was used to infect vertebrate cells at a low multiplicity of infection, single fluorescent cells resulted, which continued to divide over a period of several days, ultimately forming fluorescent cell clusters, suggesting that vertebrate cells survive the infection and continue to grow. Therefore, AmEPV may prove to be a highly efficient, nontoxic method of gene delivery into vertebrate cells for transient gene expression.
Trade-Off between Bile Resistance and Nutritional Competence Drives Escherichia coli Diversification in the Mouse Gut (2011)

Bacterial diversification is often observed, but underlying mechanisms are difficult to disentangle and remain generally unknown. Moreover, controlled diversification experiments in ecologically relevant environments are lacking. We studied bacterial diversification in the mammalian gut, one of the most complex bacterial environments, where usually hundreds of species and thousands of bacterial strains stably coexist. Herein we show rapid genetic diversification of an Escherichia coli strain upon colonisation of previously germ-free mice. In addition to the previously described mutations in the EnvZ/OmpR operon, we describe the rapid and systematic selection of mutations in the flagellar flhDC operon and in malT, the transcriptional activator of the maltose regulon. Moreover, within each mouse, the three mutant types coexisted at different levels after one month of colonisation. By combining in vivo studies and determination of the fitness advantages of the selected mutations in controlled in vitro experiments, we provide evidence that the selective forces that drive E. coli diversification in the mouse gut are the presence of bile salts and competition for nutrients. Altogether our results indicate that a trade-off between stress resistance and nutritional competence generates sympatric diversification of the gut microbiota. These results illustrate how experimental evolution in natural environments enables identification of both the selective pressures that organisms face in their natural environment and the diversification mechanisms.
Innate Lymphoid Cells and Type 2 (Th2) Mediated Immune Responses ? Pathogenic or Beneficial? (2011)

OPINION article Front. Immunol., 28 November 2011Sec. Inflammation volume 2 - 2011 | https://doi.org/10.3389/fimmu.2011.00068
Evaluation of a Multi-wavelength Reflectance System for Determination of Tissue Optical Properties in the UVA-VIS (2007)

Tissue optical properties at ultraviolet-A and visible wavelengths are needed to elucidate diagnostic device performance. We have developed a multi-wavelength fiberoptic reflectance system for optical property measurement and evaluated its performance using hemoglobin-based tissue phantoms.
Micro-architecture of the VAX 9000 (2002)

The VAX 9000 CPU, a high-performance scalar processor with an integrated vector facility, is discussed. The implementation of the macropipeline found in the four major subsystems of the VAX 9000 is highlighted. The subsystems are the instruction fetch and decode unit (IBOX), the execution unit (EBOX), the data cache and main memory interface (MBOX), and the vector processing unit (VBOX). IBOX combines a 1-cycle access virtual instruction cache with a 25-B instruction buffer and an instruction decode crossbar. The VAX 9000 EBOX performs all scalar operations. It is a pipelined design incorporating a microsequencer to control functional unit operation. The MBOX of the VAX 9000 is the primary source of memory data, and so it is the home of the actual address translation buffer and the data cache. It is multiported and pipelined with two autonomous pipeline segments. The VBOX is an optional arithmetic unit which accelerates arithmetic-intensive code applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
CORRELATION BETWEEN GANGLIOSIDE DISTRIBUTION AND HISTOLOGICAL GRADING OF HUMAN ASTROCYTOMAS (1985)

Changes in membrane lipid content and composition have been repeatedly detected in experimentally induced as well as spontaneous tumors. Previous data on ganglioside analysis in human astrocytomas suggested a possible correlation between their content and pattern and the histological grading of these tumors. In our study we could definitely prove this correlation: in fact the level of malignancy, passing from grade I to grade IV, is associated with a statistically significant increase of a ganglioside identified as ganglioside GD3. Another important modification in the ganglioside pattern of human astrocytomas is the decrease in polysialylated species with increasing level of malignancy.
UHF RFCPUs on Flexible and Glass Substrates for Secure RFID Systems (2007)

A flexible RFID tag communicates using UHF RF signals at 915MHz, consists of an 8b CPU, and employs a DES and anti-side channel attack routine in firmware. The tag realizes stable clock generation by a digital control clock generator, and occupies an area of 10.5 times 8.9mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , is 145mum thick, consumes 0.54mW at 1.5V supply, and communicates with a maximum range of 43cm at a power of 9dBm.
Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo (2004)

These results suggest that extracorporeal cardiac SW therapy is an effective and noninvasive therapeutic strategy for ischemic heart disease.
Effect of substitutions on the thermoelectric figure of merit of half-Heusler phases at 800 °C (2006)

The merit of thermally stable MNiSn (M=Ti, Zr, Hf) half-Heusler phases, as n-type thermoelectric materials, for high-temperature power generation has been examined. Sb doping at the Sn site is shown to increase both the figure of merit, ZT, and the temperature at which ZT is maximized. The benefits of increased alloying at the M and Ni sites, on the thermal conductivity and thermoelectric transport properties, have also been investigated. The thermoelectric figure of merit, ZT∼0.8 at T∼800°C, for select Sb-doped MNiSn alloys was found to meet or exceed the industry benchmark set by SiGe alloys.
A thymidine triphosphate shape analog lacking Watson–Crick pairing ability is replicated with high sequence selectivity (1997)

Compound 1 (F), a nonpolar nucleoside analog that is isosteric with thymidine, has been proposed as a probe for the importance of hydrogen bonds in biological systems. Consistent with its lack of strong H-bond donors or acceptors, F is shown here by thermal denaturation studies to pair very poorly and with no significant selectivity among natural bases in DNA oligonucleotides. We report the synthesis of the 5'-triphosphate derivative of 1 and the study of its ability to be inserted into replicating DNA strands by the Klenow fragment (KF, exo- mutant) of Escherichia coli DNA polymerase I. We find that this nucleotide derivative (dFTP) is a surprisingly good substrate for KF; steady-state measurements indicate it is inserted into a template opposite adenine with efficiency (Vmax/Km) only 40-fold lower than dTTP. Moreover, it is inserted opposite A (relative to C, G, or T) with selectivity nearly as high as that observed for dTTP. Elongation of the strand past F in an F-A pair is associated with a brief pause, whereas that beyond A in the inverted A-F pair is not. Combined with data from studies with F in the template strand, the results show that KF can efficiently replicate a base pair (A-F/F-A) that is inherently very unstable, and the replication occurs with very high fidelity despite a lack of inherent base-pairing selectivity. The results suggest that hydrogen bonds may be less important in the fidelity of replication than commonly believed and that nucleotide/template shape complementarity may play a more important role than previously believed.
Position Effects On Eukaryotic Gene Expression (1990)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate (2011)

Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to generate sphingosine-1-phosphate (S1P), a pluripotent lipophilic mediator implicated in a variety of cellular events. Here we show that the activity of β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for amyloid-β peptide (Aβ) production, is modulated by S1P in mouse neurons. Treatment by SphK inhibitor, RNA interference knockdown of SphK, or overexpression of S1P degrading enzymes decreased BACE1 activity, which reduced Aβ production. S1P specifically bound to full-length BACE1 and increased its proteolytic activity, suggesting that cellular S1P directly modulates BACE1 activity. Notably, the relative activity of SphK2 was upregulated in the brains of patients with Alzheimer's disease. The unique modulatory effect of cellular S1P on BACE1 activity is a novel potential therapeutic target for Alzheimer's disease.
The effects of acute and chronic exercise on the vasculature (2010)

Regular physical activity (endurance training, ET) has a strong positive link with cardiovascular health. The aim of this review is to draw together the current knowledge on gene expression in different cell types comprising the vessels of the circulatory system, with special emphasis on the endothelium, and how these gene products interact to influence vascular health. The effect beneficial effects of ET on the endothelium are believed to result from increased vascular shear stress during ET bouts. A number of mechanosensory mechanisms have been elucidated that may contribute to the effects of ET on vascular function, but there are questions regarding interactions among molecular pathways. For instance, increases in flow brought on by ET can reduce circulating levels of viscosity and haemostatic and inflammatory variables that may interact with increased shear stress, releasing vasoactive substances such as nitric oxide and prostacyclin, decreasing permeability to plasma lipoproteins as well as the adhesion of leucocytes. At this time the optimal rate-of-flow and rate-of-change in flow for determining whether anti-atherogenic or pro-atherogenic processes proceed remain unknown. In addition, the impact of haemodynamic variables differs with vessel size and tissue type in which arteries are located. While the hurdles to understanding the mechanism responsible for ET-induced alterations in vascular cell gene expression are significant, they in no way undermine the established benefits of regular physical activity to the cardiovascular system and to general overall health. This review summarizes current understanding of control of vascular cell gene expression by exercise and how these processes lead to improved cardiovascular health.