gebhart/patrepeval huggingface dataset:
High-performance photovoltaic perovskite layers fabricated through intramolecular exchange (2015)

The band gap of formamidinium lead iodide (FAPbI3) perovskites allows broader absorption of the solar spectrum relative to conventional methylammonium lead iodide (MAPbI3). Because the optoelectronic properties of perovskite films are closely related to film quality, deposition of dense and uniform films is crucial for fabricating high-performance perovskite solar cells (PSCs). We report an approach for depositing high-quality FAPbI3 films, involving FAPbI3 crystallization by the direct intramolecular exchange of dimethylsulfoxide (DMSO) molecules intercalated in PbI2 with formamidinium iodide. This process produces FAPbI3 films with (111)-preferred crystallographic orientation, large-grained dense microstructures, and flat surfaces without residual PbI2. Using films prepared by this technique, we fabricated FAPbI3-based PSCs with maximum power conversion efficiency greater than 20%.
Chemistry of tissues. 4. Methylation studies on hyaluronic acid (1951)

The hypothesis is advanced that a diet high in sucrose stimulates the processes of mineralization by maintaining a maximum level of glycogen in the developing tooth.
Antibody Imprint of a Membrane Protein Surface (1998)

Structural features of the integral membrane protein flavocytochrome b (Cyt b) were discovered using an antibody "imprint" of the Cyt b surface. Amino acid sequences were selected from a random nonapeptide phage-display library by their affinity for the monoclonal antibody 44.1 binding site, which recognizes the native conformation of the p22 subunit of Cyt b. Transferred nuclear Overhauser effect spectroscopy and rotating frame Overhauser effect spectroscopy NMR were used to study the antibody-bound conformation of a synthetic peptide derived from phage-displayed sequences. The NMR data supported the phage-display analysis suggesting the existence of a complex epitope and allowed the modeling of the close spatial proximity of the epitope components 29TAGRF33 and 183PQVNPI188 from discontinuous regions of p22. Although these regions are separated by two putative membrane-spanning domains and are 150 residues apart in the sequence, they appear to combine to form a complex epitope on the cytosolic surface of the transmembrane protein. NMR constraints, measured from the antibody-bound conformation of a composite peptide mimetic of the Cyt b epitope, and one constraint inferred from the phage-display results, were used to demonstrate the close proximity of these two regions. This information provides a low resolution view of the tertiary structure of the native discontinuous epitope on the Cyt b surface. Given additional antibodies, such imprint analysis has the potential for producing structural constraints to help support molecular modeling of this and other low abundance or noncrystallizable proteins.
Fast motion vector estimation using multiresolution-spatio-temporal correlations (1997)

We propose a new fast algorithm for block motion vector (MV) estimation based on the correlations of the MVs existing in spatially and temporally adjacent as well as hierarchically related blocks. We first establish a basic framework by introducing new algorithms based on spatial correlation and then spatio-temporal correlations before integrating them with a multiresolution scheme for the ultimate algorithm. The main idea is to effectively exploit the information obtained from the corresponding block at a coarser resolution level and spatio-temporal neighboring blocks at the same level in order to select a good set of initial MV candidates and then perform further local search to refine the MV result. We show with experimental results that, in comparison with the full search algorithm, the proposed algorithm achieves a speed-up factor ranging from 150 to 310 with only 2-7% mean square error (MSE) increase and a similar rate-distortion performance when applied to typical test video sequences.
The mGluR6 5′ Upstream Transgene Sequence Directs a Cell-Specific and Developmentally Regulated Expression in Retinal Rod and ON-Type Cone Bipolar Cells (1997)

We generated transgenic mice, using 9.5 kilobase pairs of the 5' upstream sequence from the mouse metabotropic glutamate receptor subtype 6 (mGluR6) gene fused to the beta-galactosidase (lacZ) reporter gene, and investigated the promoter function of the cell-specific and developmentally regulated expression of mGluR6. Most of the independent transgenic lines commonly showed the lacZ expression in the defined cell layers of the retina, and four transgenic lines were characterized in detail for cell-specific lacZ expression patterns by X-gal staining and lacZ immunostaining. The lacZ-expressing retinal cells were classified into two cell types. One cell type was identified as rod bipolar cells on the basis of colocalization of protein kinase C (PKC) immunoreactivity and morphological criteria. The other cell type was PKC-immunonegative and resided at the cell layers corresponding precisely to ON-type cone bipolar cells. The latter bipolar cells were found to exist as a large cell population comparable to rod bipolar cells. This observation was confirmed by coimmunostaining of dissociated retinal cells with the lacZ and PKC antibodies. The ontogeny analysis indicated that the lacZ expression completely agrees with a temporal expression pattern of mGluR6 during retinal development. This study demonstrates that the mGluR6 5' upstream genomic sequence is capable of directing a cell-specific and developmentally regulated expression of mGluR6 in ON-type bipolar cells and supports the view that mGluR6 is responsible for ON responses in both the rod and cone systems.
Pressure and Blanchard Altitudes Computed from Atmospheric Data Gathered from May through July 2000 at White Sands, New Mexico (2001)

An altitude reference is usually required to damp the error 
growth in the inherently unstable vertical channel of an 
Inertial Navigation System (INS). This altitude reference 
is commonly obtained by computing the pressure altitude 
based on a standard atmospheric model for the standard 
day via the aircraft Central Air Data Computer (CADC). 
However, due to significant errors in pressure altitude, the 
altitude and vertical velocity errors exhibited by the pressure altitude stabilized vertical channel can be 
unacceptably large and this can adversely impact high 
accuracy applications such as landing on an aircraft 
carrier and weapon delivery. A more precise altitude 
reference for use in the INS vertical channel can be 
obtained using the Blanchard algorithm, which computes 
altitude from atmospheric pressure, temperature, aircraft 
ground velocity, and wind velocity data. 
In order to compare the pressure and Blanchard altitude 
errors, atmospheric data gathered from May through July 
2000 at White Sands Missile Range, New Mexico was 
utilized from radiosonde measurements taken at altitudes 
from approximately 4,100 ft to 60,000 ft (18.3 km). The 
radiosonde is an instrument carried aloft by a balloon; it 
sends atmospheric pressure, temperature, and humidity to 
the ground by means of a small radio transmitter. 
This paper describes the algorithms and results of the 
pressure and Blanchard altitude computations from the 
weather data collected at White Sands Missile Range 
from May through July 2000. Comparison of pressure and 
Blanchard altitude errors shows that Blanchard altitude is 
a much more precise altitude reference than pressure 
altitude for the atmospheric data gathered in the May 
through July 2000 time frame at White Sands Missile 
Range.
Infectious Complications in Adults with Bone Marrow Transplantation and T-Cell Depletion of Donor Marrow (1986)

The infectious complications of bone marrow transplantation were reviewed in 43 adults, 22 of whom received transplants from HLA-matched donors without T-cell depletion and 21 of whom received donor marrow pretreated with the murine anti-T-cell monoclonal antibody CT-2 and complement. Recipients of HLA-mismatched, T-cell-depleted transplants had a higher rate of bacteremia (1.33 compared with 0.64 per patient, p = 0.05) and especially systemic fungal infections (0.92 compared with 0.14 per patient, p less than 0.001) than recipients of transplants from HLA-identical donors without T-cell depletion; two thirds of these infections occurred during the granulocytopenic period early after transplantation. Recipients of HLA-identical but T-cell-depleted transplants also had significantly more systemic fungal infections (0.77 per patient, p less than 0.001). T-cell depletion was associated with delayed engraftment, more prolonged granulocytopenia, and more severe lymphopenia and was shown by stepwise multivariate regression analysis to be the most powerful predictor of systemic fungal infection (r = 0.512, p less than 0.0001). Whereas ex-vivo T-cell depletion may reduce the risk of severe graft-versus-host disease, it may predispose the patient to infection, especially with fungi.
Urate transport in the proximal tubule: in vivo and vesicle studies (1985)

The transport of urate in the mammalian nephron is largely confined to the proximal tubule. Depending on the species, net reabsorption or net secretion is observed. The rat, like the human and the mongrel dog, demonstrates net reabsorption of urate and has been the most extensively studied species. The unidirectional reabsorption and secretion of urate in the rat proximal tubule occur via a passive and presumably paracellular route and by a mediated transcellular route. The reabsorption of urate, and possibly its secretion, can occur against an electrochemical gradient. A variety of drugs and other compounds affect the reabsorption and secretion of urate. The effects of these agents depend on their site of application (luminal or blood), concentration, and occasionally their participation in transport processes that do not have affinity for urate. Recent studies with renal brush border and basolateral membrane vesicles from the rat and brush border vesicles from the dog have determined the mechanisms for urate transport across the luminal and antiluminal membranes of the proximal tubule cell. Brush border membrane vesicles contain an anion exchanger with affinity for urate, hydroxyl ion, bicarbonate, chloride, lactate, p-aminohippurate (PAH), and a variety of other organic anions. Basolateral membrane vesicles contain an anion exchanger with affinity for urate and chloride but not for PAH. Both membrane vesicle preparations also permit urate translocation by simple diffusion. A model for the transcellular reabsorption and secretion of urate in the rat proximal tubule is proposed. This model is based on the vesicle studies, and it can potentially explain the majority of urate transport data obtained with in vivo techniques.
Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis (2000)

Apoptosis or programmed cell death plays an essential role during development of the immune system, in immune responses, and in the control of tissue homeostasis in the adult. An important physiological mediator of apoptosis is the Fas/APO-1/CD95 receptor (FasR), a surface receptor belonging to the tumor necrosis factor receptor family. Apoptosis consists of a series of characteristic features that occur following activation of caspases, a collective term for apoptosis-specific proteases. The focus in FasR research has been on determining the mechanisms resulting in caspase activation. However, the role of phosphorylation-based signaling has received increasing attention both as an outcome of FasR activation and as a factor regulating FasR responses. Tyrosine-directed phosphorylation has been implicated to be induced and required during FasR stimulation. The FasR also activates all major signaling pathways that belong to the family of mitogen-activated protein kinase (MAPK) pathways, by either caspase-independent or -dependent mechanisms. Furthermore, phosphorylation-based signaling serves as a potent modifier of FasR responses. In this respect, especially the extracellular signal-regulated kinase and the phosphoinositide 3-kinase signaling pathways have been established as important regulators. This type of control seems to be directly phosphorylation-mediated without the requirement of newly synthesized proteins. Signaling through phosphorylation also regulates the expression of the Fas ligand (FasL), the FasR, as well as various other proteins that affect the outcome of receptor stimulation. While the involvement of phosphorylation has been established in FasR responses, the targets, molecular mechanisms, and biological significance of this aspect of the FasR signaling machinery still require further elucidation.
Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0 /G1 Phase of the Cell Cycle (1997)

Using simultaneous Hoechst 33342 (Hst) and Pyronin Y (PY) staining for determination of DNA and RNA content, respectively, human CD34+ cells were isolated in subcompartments of the G0 /G1 phase of the cell cycle by flow cytometric cell sorting. In both bone marrow (BM) and mobilized peripheral blood (MPB) CD34+ cells, primitive long-term hematopoietic culture-initiating cell (LTHC-IC) activity was higher in CD34+ cells isolated in G0 (G0CD34+ cells) than in those residing in G1 (G1CD34+ cells). However, as MPB CD34+ cells displayed a more homogeneous cell-cycle status within the G0 /G1 phase and a relative absence of cells in late G1 , DNA/RNA fractionation was less effective in segregating LTHC-IC in MPB than in BM. BM CD34+ cells belonging to four subcompartments of increasing RNA content within the G0 /G1 phase were evaluated in functional assays. The persistence of CD34 expression in suspension culture was inversely correlated with the initial RNA content of test cells. Multipotential progenitors were present in G0 or early G1 subcompartments, while lineage-restricted granulomonocytic progenitors were more abundant in late G1 . In vitro hematopoiesis was maintained for up to 6 weeks with G0CD34+ cells, whereas production of clonogenic progenitors was more limited in cultures initiated with G1CD34+ cells. To test the hypothesis that primitive LTHC-ICs would reenter a state of relative quiescence after in vitro division, BM CD34+ cells proliferating in ex vivo cultures were identified from their quiescent counterparts by a relative loss of membrane intercalating dye PKH2, and were further fractionated with Hst and PY. The same functional hierarchy was documented within the PKH2dim population whereby LTHC-IC frequency was higher for CD34+ cells reselected in G0 after in vitro division than for CD34+ cells reisolated in G1 or in S/G2 + M. However, the highest LTHC-IC frequency was found in quiescent PKH2bright CD34+ cells. Together, these results support the concept that cells with distinct hematopoietic capabilities follow different pathways during the G0 /G1 phase of the cell cycle both in vivo and during ex vivo culture.
Reanalysis of Old Eötvös Data Suggests 5th Force…To Some (1986)

Newton's gravitational constant has been with us for three centuries. Yet despite our long and intimate acquaintance, we know this fundamental constant of nature to little better than a part per thousand. Astronomical data are of scant use, because they always involve G multiplied by the mass of the Earth or some celestial body, and our knowledge of the mean density of such bodies is even more uncertain. Our best knowledge of G comes from modern variants of the classic Cavendish experiment, measuring the horizontal force between test bodies at distances up to a few meters in the laboratory.
Some closure features of locally testable affine-invariant properties (2013)

We prove that the class of locally testable affine-invariant properties is closed under sums, intersections and “lifts”. The sum and intersection are two natural operations on linear spaces of functions, where the sum of two properties is simply their sum as a vector space. The “lift” is a less natural property that has been studied before. Previously such results were known for “single-orbit characterized ” affine-invariant properties, which known to be a subclass of locally testable ones, and are potentially a strict subclass. The fact that the intersection of locally-testable affine-invariant properties are locally testable could have been derived from previously known general results on closure of property testing under set-theoretic operations, but was not explicitly observed before. The closure under sum and lifts is implied by an affirmative answer to a central question attempting to characterize locally testable affine-invariant properties, but the status of that question remains wide open. Affine-invariant properties are clean abstractions of commonly studied, and extensively used, algebraic properties such linearity and low-degree. Thus far it is not known what makes affine-invariant properties locally testable — no characterizations are known, and till this work it was not clear if they satisfied any closure properties. This work shows that the class of locally testable affine-invariant properties are closed under some very natural operations. Our tech-niques use ones previously developed for the study of “single-orbit characterized ” properties, but manage to apply them to the potentially more general class of all locally testable ones via a simple connection that may be of broad interest in the study of affine-invariant properties.
Tuberous Sclerosis Complex and Epilepsy: Recent Developments and Future Challenges (2007)

Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs, caused by mutations in one of the tumor suppressor genes, TSC1 or TSC2. About 80% of affected patients have a new mutation, and the remaining 20% have inherited a TSC gene mutation from a parent. The disorder affects approximately 1 in 6000 individuals. Cortical tubers are the neuropathological hallmark of TSC. The most common neurological manifestations of TSC are epilepsy, mental retardation, and autistic behavior. Epilepsy occurs in up to 80-90% of patients and is often intractable, with a poor response to anticonvulsant medications. While the molecular basis of TSC is well established, far less is known about the mechanisms of epilepsy in this disorder. In this article, we first summarize known clinical aspects of TSC with emphasis on its neurological features. Then, based on the molecular, pathological, immunohistochemical, neurochemical, and physiological properties of tubers in patients with TSC and in animal models, we discuss possible mechanisms of seizures and epileptogenesis in TSC. Finally, we provide an updated literature review and a consensus statement from the Tuberous Sclerosis Complex Working Group for future research into the mechanisms of epilepsy in TSC.
Antisense technology: biological utility and practical considerations (1993)

Antisense RNA and DNA techniques have been developed as a relatively recent approach to the specific modulation of gene expression in vitro and in vivo. This review discusses general considerations for the application of antisense techniques. We shall examine the relative advantages and disadvantages of DNA versus RNA techniques, as well as the common pitfalls peculiar to each strategy.
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains (2007)

Glucagon, a hormone secreted from the alpha-cells of the endocrine pancreas, is critical for blood glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia to induce hepatic glucose output. The control of glucagon secretion is multifactorial and involves direct effects of nutrients on alpha-cell stimulus-secretion coupling as well as paracrine regulation by insulin and zinc and other factors secreted from neighboring beta- and delta-cells within the islet of Langerhans. Glucagon secretion is also regulated by circulating hormones and the autonomic nervous system. In this review, we describe the components of the alpha-cell stimulus secretion coupling and how nutrient metabolism in the alpha-cell leads to changes in glucagon secretion. The islet cell composition and organization are described in different species and serve as a basis for understanding how the numerous paracrine, hormonal, and nervous signals fine-tune glucagon secretion under different physiological conditions. We also highlight the pathophysiology of the alpha-cell and how hyperglucagonemia represents an important component of the metabolic abnormalities associated with diabetes mellitus. Therapeutic inhibition of glucagon action in patients with type 2 diabetes remains an exciting prospect.
DGPS broadcasts using the Radio Broadcast System (RBDS) for IVHS (1993)

The Global Positioning System (GPS) is the primary choice in intelligent vehicle highway systems (IVHS) for vehicle location monitoring. The use of GPS technology in the autonomous mode is not accurate enough in urban environments. The major problem in vehicle location monitoring has been providing some form of efficient digital GPS (DGPS) correction broadcast. A cost effective solution to providing DGPS corrections for IVHS uses the new Radio Broadcast Data Standard (RBDS). The standard defines the broadcast format for transmitting data over existing FM radio station subcarriers.
Small bowel bacterial overgrowth in subjects living in residential care homes (1999)

the percentage of volunteers with a positive breath test was much lower than in previous studies. This may be due to the relatively unselected nature of the volunteers. Treatment of bacterial overgrowth resulted in a small but significant improvement in anthropometric indices. The lack of association of positive breath tests with baseline anthropomorphic measurements or bowel habit highlights the occult nature of the bacterial overgrowth and questions its clinical importance.
Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors. (1993)

Interleukin (IL)-1 refers to a group of three polypeptide hormones with a wide range of cellular targets. Two types of IL-1 receptor have been identified and characterized by cDNA cloning. Both human type I and type II IL-1 receptors contain extracellular domains of approximately 310 residues and a single membrane-spanning region. The type I receptor contains a cytoplasmic domain of 213 residues. The cytoplasmic region of the type II receptor is 29 residues in length. It has been found recently that a number of cells express both forms of receptor. By analogy with other cytokine receptor systems, the two IL-1 receptors might be expected to form a heterodimeric complex, the type II receptor being an alpha-chain-like structure, functioning only to bind ligand, and associating with the type I receptor (a beta-chain-like structure) which would transduce signals. In this report we show that this is not the case, but rather that IL-1, when complexed to type II receptor, cannot bind type I receptors, and vice versa. These data show that the complex patterns often observed for IL-1 binding to cells cannot be accounted for by the same type of mechanism that underlies the behavior of, for example, the IL-2 system.
The Application of Spatial Shifting for Peak-to-Average Power Ratio Reduction in MIMO OFDM Systems (2006)

This paper investigates the application of spatial shifting (SS) of partial transmit sequences (PTSs) in multiple-input multiple-output OFDM. The technique rearranges the transmit (TX) vector in such a way that subparts are transmitted on those TX branches that result in the lowest overall peak-to-average power ratio. The application of different subcarrier grouping schemes and the combination of SS with phase shifting (PS) of the PTSs is investigated. Furthermore, a transparent extension of the techniques, without extra signalling overhead, is proposed. Numerical results prove the effectiveness of the SS and the combined SS/PS approach