gebhart/patrepeval huggingface dataset:
METAL-DIELECTRIC COMPOSITE FILTERS WITH CONTROLLED SPECTRAL WINDOWS OF TRANSPARENCY (2003)

In this report we show the possibility of broadband low-pass filters with windows of transparency in pre-set spectral ranges. Those filters are based on the unique optical properties of metal-dielectric composites near the percolation threshold. In such composites, metal clusters of different sizes and shapes have different plasmon resonances and resonate nearly independently at different wavelengths. All together, the resonant plasmon modes cover a very broad spectral range. Applying the effect of spectrally selective photo-modification, we develop a procedure that creates mid-infrared windows of transparency within the broadband filters. We also investigate the possibilities of making low-pass filters composed of spheroids and conductive sticks with certain distributions of aspect ratios.
Soluble Adhesion Molecules Reflect Endothelial Cell Activation in Ischemic Stroke and in Carotid Atherosclerosis (1997)

The elevated levels of sE-selectin indicate that endothelial cell activation occurs both in the acute stage of ischemic stroke and in previously symptomatic carotid atherosclerosis. Increased sP-selectin concentrations reflect endothelial cell activation as well but may also be caused by platelet activation.
Effect of Six Decades of Selective Breeding on Soybean Protein Composition and Quality:  A Biochemical and Molecular Analysis (2006)

To evaluate the extent of the genetic change and its effects on the seed protein composition of soybean cultivars released during the past 60 years, representative ancestral cultivars and those derived from selective breeding were grown in a side-by-side comparison. Total seed protein content, determined by combustion analysis of nitrogen, revealed a decline in the protein content after decades of selection and breeding. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis comparison of protein profiles of the soybean cultivars indicated that relative expression of most of the seed storage proteins had not varied substantially from the ancestral lines to the present commercial cultivars. There was noticeably less beta-subunit of beta-conglycinin, a protein devoid of sulfur amino acids, in the modern cultivars represented by Mustang, Pioneer 93B09, and Asgrow 3602. Comparison of the amino acid profiles of soybean seed, a benchmark of the protein's nutritional quality, revealed that the ancestral progenitor, G. soja, was significantly higher in cysteine, glutamic acid, histidine, and arginine than either the ancestral or the modern cultivars. Selective breeding over the past 60 years minimally affected the overall amino acid composition. The degree of divergence in the DNA sequence of the genes encoding glycinin and beta-conglycinin in the ancestral and modern cultivars was investigated using Southern hybridization and the polymerase chain reaction. Even though some restriction fragment polymorphisms could be detected, overall, the banding patterns were remarkably similar among the ancestral cultivars and those derived from them, suggesting a high degree of conservation of seed-storage protein genes. The results of our study suggest that selection and breeding for yield during the past 60 years had no major influence on the protein composition, ostensibly because of limited genetic diversity among the parental lines.
Chemical natures and distributions of metal impurities in multicrystalline silicon materials (2006)

Abstract We present a comprehensive summary of our observations of metal‐rich particles in multicrystalline silicon (mc‐Si) solar cell materials from multiple vendors, including directionally‐solidified ingot‐grown, sheet, and ribbon, as well as multicrystalline float zone materials contaminated during growth. In each material, the elemental nature, chemical states, and distributions of metal‐rich particles are assessed by synchrotron‐based analytical x‐ray microprobe techniques. Certain universal physical principles appear to govern the behavior of metals in nearly all materials: (a) Two types of metal‐rich particles can be observed (metal silicide nanoprecipitates and metal‐rich inclusions up to tens of microns in size, frequently oxidized), (b) spatial distributions of individual elements strongly depend on their solubility and diffusivity, and (c) strong interactions exist between metals and certain types of structural defects. Differences in the distribution and elemental nature of metal contamination between different mc‐Si materials can largely be explained by variations in crystal growth parameters, structural defect types, and contamination sources. Copyright © 2006 John Wiley &amp; Sons, Ltd.
A novel symbiotic nitrogen-fixing member of the Ochrobactrum clade isolated from root nodules of Acacia mangiu (2004)

Ten strains of root nodule bacteria were isolated from the nodules of Acacia mangium grown in the Philippines and Thailand. Partial sequences (approx. 300 bp) of the 16S rRNA gene of each isolate were analyzed. The nucleotide sequences of strain DASA 35030 indicated high homology (>99%) with members of the genus Ochrobactrum in Brucellaceae, although the sequences of other isolates were homologous to those of two distinct genera Bradyrhizobium and Rhizobium. The strain DASA 35030 was strongly suggested to be a strain of Ochrobactrum by full length sequences of the 16S rRNA gene, fatty acids composition, G+C contents of the DNA, and other physiological characteristics. Strain DASA 35030 induced root nodules on A. mangium, A. albida and Paraserianthes falcataria. The nodules formed by strain DASA 35030 fixed nitrogen and the morphology of the nodules is the same as those of nodules formed by the other isolates. This is the first report that the strain of Ochrobactrum possesses complete symbiotic ability with Acacia.
Splice Modification to Restore Functional Dystrophin Synthesis in Duchenne Muscular Dystrophy (2010)

In little more than a decade, induced exon skipping as a therapy to treat Duchenne muscular dystrophy (DMD) has progressed from a concept tested in vitro, to pre-clinical evaluation in mouse and dog models, and recent completion of Phase I clinical trials in man. There is no longer any doubt that antisense oligomers can redirect dystrophin gene processing and by-pass protein truncating mutations after direct injection into muscle. Proof-of-concept has been demonstrated in human dystrophic muscle, with trials in Leiden and London showing that two different oligomer chemistries can restore the reading-frame in selected DMD patients by excising dystrophin exon 51. Systemic delivery of both oligomer types into DMD patients has commenced with promising results but it remains to be established if this therapy will have measurable clinical benefits. Targeted removal of exon 51 will only be directly applicable to about one in ten DMD individuals, and the immediate challenges include development of appropriate and effective delivery regimens, and extending splice-switching therapies to other dystrophin gene lesions. The success of induced exon skipping has spawned a number of "fusion therapies", including vector-mediated dystrophin exon skipping and ex vivo viral delivery of splice-switching antisense molecules into myogenic stem cells, followed by implantation, which may address long term oligomer delivery issues. This review summarizes the pivotal events leading to the completion of the first proof-of-concept trials and speculates on some of the scientific, ethical, regulatory and commercial challenges facing targeted exon skipping for the treatment of DMD.
M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis (2009)

Antiangiogenic therapy for the treatment of cancer and other neovascular diseases is desired to be selective for pathological angiogenesis and lymphangiogenesis. Macrophage colony-stimulating factor (M-CSF), a cytokine required for the differentiation of monocyte lineage cells, promotes the formation of high-density vessel networks in tumors and therefore possesses therapeutic potential as an M-CSF inhibitor. However, the physiological role of M-CSF in vascular and lymphatic development, as well as the precise mechanisms underlying the antiangiogenic effects of M-CSF inhibition, remains unclear. Moreover, therapeutic potential of M-CSF inhibition in other neovascular diseases has not yet been evaluated. We used osteopetrotic (op/op) mice to demonstrate that M-CSF deficiency reduces the abundance of LYVE-1(+) and LYVE1(-) macrophages, resulting in defects in vascular and lymphatic development. In ischemic retinopathy, M-CSF was required for pathological neovascularization but was not required for the recovery of normal vasculature. In mouse osteosarcoma, M-CSF inhibition effectively suppressed tumor angiogenesis and lymphangiogenesis, and it disorganized extracellular matrices. In contrast to VEGF blockade, interruption of M-CSF inhibition did not promote rapid vascular regrowth. Continuous M-CSF inhibition did not affect healthy vascular and lymphatic systems outside tumors. These results suggest that M-CSF-targeted therapy is an ideal strategy for treating ocular neovascular diseases and cancer.
Sterospecific Syntheses and Spectroscopic Properties of Isomeric 2,4,6,8‐Undecatetraenes. New Hydrocarbons from the Marine Brown Alga Giffordia mitchellae. Part IV. (1987)

Abstract Giffordene (=(2 Z ,4 Z ,6 E ,8 Z )‐2,4,6,8‐undecatetraene; 9f ) and five steroisomers are new C 11 H 16 hydrocarbons from the marine brown alga Giffordia mitchellae . Their synthesis is based on non‐stereoselective Wittig reactions of ( E )‐2‐alkenals with appropriate acetylenic phosphoranes and subsequent chromatographic separation of the resulting ( E/Z )‐pairs. The uniform enynes (&gt;98% purity) are then stereospecifically reduced to ( Z )‐alkenes with Zn(Cu/Ag) in aq. MeOH at r.t. 13 C‐ and 1 H‐NMR data of the new tetraenes are presented. Biosynthetically, giffordene ( 9f ) originates from dodeca‐3,6,9‐trienoic acid via an unstable (3 Z ,5 Z ,8 Z )‐1,3,5,8,‐undecatetraene followed by a thermally allowed antarafacial 1,7‐sigmatropic hydrogen shift to the (2 Z ,4 Z ,6 E ,8 Z )‐isomer 9f .
Induction of Ferritin Synthesis by Oxidative Stress (1995)

Ferritin, by regulating the "free" intracellular iron pool, controls iron-catalyzed generation of reactive oxygen species, but its role in oxidative damage is still unclear. We show that ferritin synthesis is significantly stimulated in the liver of rats subjected to oxidative stress by treatment with phorone, a glutathione-depleting drug. RNA-bandshift assays document reduced activity of iron regulatory factor, in particular of IRFB, the cytoplasmic protein that post-transcriptionally controls ferritin mRNA translation. Furthermore, Northern blot analysis shows increased accumulation of H and L subunit mRNAs, and nuclear run-on experiments provide evidence of transcriptional activation. Direct measurements of intracellular free iron levels by EPR indicate that the increased ferritin synthesis can be mediated by an expansion of the free iron pool. An early drop of ferritin content after phorone treatment indicates that part of the iron that fuels the free pool might derive from ferritin degradation. Present data seem to suggest that, under conditions of oxidative stress, liver ferritin can represent either a pro- or an anti-oxidant in a time-dependent manner. In fact, its early degradation contributes to expand the intracellular free iron pool that, later on, activates multiple molecular mechanisms to reconstitute ferritin content, thus limiting the pro-oxidant challenge of iron.
Glycaemic separation and risk factor control in the Veterans Affairs Diabetes Trial: an interim report (2008)

VADT is maintaining the expected A1C in both STD and INT, and LDL-C, triglycerides and blood pressure are at target. The trial is continuing to June 2008. It will be the first long-term completed type 2 diabetes study of the role of glycaemia on CV disease with modern treatments.
Self‐Supported Formation of Needlelike Co3O4 Nanotubes and Their Application as Lithium‐Ion Battery Electrodes (2007)

A one-step, self-supported topotactic transformation approach for synthesizing electrochemically active Co3O4 needlelike nanotubes is reported. Used as the active material in the negative electrode of a rechargeable lithium ion battery, the Co3O4 nanotubes manifest ultrahigh Li storage capacity with improved cycle life and rate capability. These features are discussed in terms of the unique structure of the materials. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2008/c2412_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
BIOCHEMISTRY OF THE SOLUBLE METHANE MONOOXYGENASE (1994)

The soluble form of methane monooxygenase (MMO) catalyzes the reaction NAD(P)H + O2 + CH4 + H+-->NAD(P)+ + H2O + CH3OH. Many other hydrocarbons serve as adventitious substrates. MMO consists of three protein components: component B, reductase, and hydroxylase (MMOH), the active site of which contains a hydroxo-bridged dinuclear iron cluster that is the site of catalysis. Such a cluster has not been previously associated with oxygenases, and spectroscopic studies have been conducted to ascertain its structural features and accessibility. The mechanism of MMO has been investigated through the use of diagnostic chemical reactions and transient kinetics. Both approaches are consistent with a mechanism in which the diiron cluster is first reduced to the diferrous state and then reacts with O2. The O-O bond is apparently cleaved heterolytically to yield water and an [Fe(IV).Fe(IV)]=O species, which purportedly abstracts a hydrogen atom from methane to yield a substrate radical and a diiron cluster-bound hydroxyl radical. Recombination of the radicals yields the product methanol. An intermediate with the properties of the novel [Fe(IV).Fe(IV)] = O species has been trapped and characterized. This is the first such species to be isolated in biology. Meanwhile, the reductase and component B have roles in catalysis beyond simple electron transfer from NAD(P)H. These roles appear to be related to regulation of catalysis, and are mediated by the formation of specific component complexes that alter the physical and catalytic properties of MMOH at different stages of the turnover cycle.
Chronic Sequelae of Foodborne Disease (1997)

In the past decade the complexity of foodborne pathogens, as well as their adaptability and ability to cause acute illness, and in some cases chronic (secondary) complications, have been newly appreciated. This overview examines long-term consequences of foodborne infections and intoxications to emphasize the need for more research and education.
High and intermediate resolution DNA typing systems for class I HLA-A, B, C genes by hybridization with sequence-specific oligonucleotide probes (SSOP). (1999)

DNA typing systems for alleles of the HLA class I loci A, B, C at intermediate (IR) and high resolution (HR) levels were developed. The approaches combine locus-specific amplification of genomic DNA by the polymerase chain reaction (PCR) and hybridization with sequence-specific oligonucleotide probes (SSOP). The SSOP were designed to match nucleotide sequences at all polymorphic sites of exons 2 and 3 at these loci. Alleles and genotypes for these loci are assigned by their unique hybridization patterns. Some genotypes with particular allele combinations resulted in the same hybridization pattern. These genotype ambiguities were resolved by performing additional group-specific amplifications with appropriate GSA primers and hybridization with informative SSOP. At intermediate resolution level, many groups of alleles of HLA-A and B with the same serologic equivalence resulted in the same hybridization pattern. Both HR and IR typing approaches required the design, validation and testing of locus- and group-specific primers and sequence-specific oligonucleotide probes (SSOP). Single locus-specific amplification and hybridization with sets of 67 SSOP for HLA-A, 99 for HLA-B and 57 for HLA-C allowed us to identify unequivocally the majority of A, B, C alleles at HR level. To resolve ambiguous genotypes at HLA-B, we performed 4 GSA with 5' primers at codon 45-46 and hybridization with selected sets of SSOP. About 22,415 high resolution typing results were obtained (4,953A, 6,621B, 10,841C). In these samples, 63 HLA-A, 170 HLA-B and 40 HLA-C alleles were observed. In the course of these studies, more than 30 new alleles have been identified. In IR testing, sets of 39 SSOP for HLA-A typing and 59 SSOP for HLA-B typing allowed us to obtain maximal resolution of the majority of common genotypes. To achieve IR level, the majority of SSOP selected were those that span codons encoding amino acid residues located in the alpha helical segments of the class I molecules. A total of 50,522 samples were typed for HLA-A and B at IR level. Approximately 2.0% of them carried ambiguous genotypes associated with alternative switches of Bw4/w6 related sequences. All these ambiguities were resolved by Bw4/Bw6 GSA by 2 primer pairs (77N-IALR-83/3B.1; 77S-DLRG-83/3B.1) and hybridization with 9 selected SSOP Testing was performed by individual hybridization of replicate dot blot membranes with the SSOP of the corresponding set. The approach was robust and cost-effective in large-scale HLA class I molecular typing. The resolution provided by HLA-A, B IR reached serologic split-level or higher. The description of primers and probes for HLA class I typing may be utilized as starting elements for development of second generation methods with a more rapid turn around time.
Picosecond Q-switched microchip lasers (2002)

Q-switched microchip lasers have the potential to produce pulses of less than 100-ps duration with peak powers in excess of 1 MW. Here the author designs a Nd:YAG microchip laser.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Line-by-line pulse shaping control for optical arbitrary waveform generation (2005)

We demonstrate a fundamental operation for generating complex waveforms in the optical domain - line-by-line pulse shaping control for optical arbitrary waveform generation (O-AWG). Independent manipulation of the spectral amplitude and phase of individual lines from a mode-locked frequency comb, or spectral line-by-line pulse shaping, leads to synthesis of user-specified ultrafast optical waveforms with unprecedented control. Coupled with recent advances in frequency stabilized mode-locked lasers, line-by-line pulse shaping control should have significant impact to fields drawing upon developments in the field of ultrafast science.
Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. (1993)

A human glioblastoma cell line produced VEGF, which enhanced the proliferation of BCE cells and induced an elongated shape in collagen gels. VEGF and bFGF increased the rate of proliferation and the number of cord-like structures in a synergistic manner.
R2D2: Repeatable and Reliable Detector and Descriptor (2019)

Interest point detection and local feature description are fundamental steps in many computer vision applications. Classical methods for these tasks are based on a detect-then-describe paradigm where separate handcrafted methods are used to first identify repeatable keypoints and then represent them with a local descriptor. Neural networks trained with metric learning losses have recently caught up with these techniques, focusing on learning repeatable saliency maps for keypoint detection and learning descriptors at the detected keypoint locations. In this work, we argue that salient regions are not necessarily discriminative, and therefore can harm the performance of the description. Furthermore, we claim that descriptors should be learned only in regions for which matching can be performed with high confidence. We thus propose to jointly learn keypoint detection and description together with a predictor of the local descriptor discriminativeness. This allows us to avoid ambiguous areas and leads to reliable keypoint detections and descriptions. Our detection-and-description approach, trained with self-supervision, can simultaneously output sparse, repeatable and reliable keypoints that outperforms state-of-the-art detectors and descriptors on the HPatches dataset. It also establishes a record on the recently released Aachen Day-Night localization dataset.
Current Approaches in the Treatment of Relapsed and Refractory Acute Myeloid Leukemia (2015)

The limited sensitivity of the historical treatment response criteria for acute myeloid leukemia (AML) has resulted in a different paradigm for treatment compared with most other cancers presenting with widely disseminated disease. Initial cytotoxic induction chemotherapy is often able to reduce tumor burden to a level sufficient to meet the current criteria for "complete" remission. Nevertheless, most AML patients ultimately die from their disease, most commonly as clinically evident relapsed AML. Despite a variety of available salvage therapy options, prognosis in patients with relapsed or refractory AML is generally poor. In this review, we outline the commonly utilized salvage cytotoxic therapy interventions and then highlight novel investigational efforts currently in clinical trials using both pathway-targeted agents and immunotherapy based approaches. We conclude that there is no current standard of care for adult relapsed or refractory AML other than offering referral to an appropriate clinical trial.
Perpendicular anisotropy in granular Co–Zr–O films (2005)

Soft granular Co–M–O films have promise for application in high-frequency thin-film inductors. But granular Co-based films are often found with perpendicular anisotropy, which can result in stripe domains and poor hysteresis behavior. Film microstructure was analyzed for Co-rich Co–Zr–O granular films with and without stripe-domain behavior. It is suggested that perpendicular anisotropy originates from columnar structure with Co columns perpendicular to film plane. The appearance of columnar structure is determined by sputter pressure and oxygen content.
Neurophysiology of stress urinary incontinence. (2004)

Stress urinary incontinence (SUI) involves involuntary leakage of urine in response to abdominal pressure caused by activities such as sneezing and coughing. The condition affects millions of women worldwide, causing physical discomfort as well as social distress and even social isolation. Until recently, SUI was approached by clinicians as a purely anatomic problem requiring behavioral or surgical therapy. Over the past several years, extensive basic and clinical research in the field of neurourology has enhanced our understanding of the complex neural circuitry regulating normal function of the lower urinary tract. As a result, novel concepts have emerged regarding possible neurologic dysfunctions that might underlie the development of SUI, as well as potential novel strategies for pharmacologic therapy. This article reviews the normal neurophysiologic control of lower urinary tract function and considers potential pharmacologic approaches to correcting SUI.
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack (2006)

In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day reduced the overall incidence of strokes and of cardiovascular events, despite a small increase in the incidence of hemorrhagic stroke. (ClinicalTrials.gov number, NCT00147602 [ClinicalTrials.gov].).