gebhart/patrepeval huggingface dataset:
On the Accuracy of Appliance IdentificationBased on Distributed Load Metering Data (2012)

Dynamic load management, i.e., allowing electricity utilities to remotely turn electric appliances in households on or off, represents a key element of the smart grid. Appliances should however only be disconnected from mains when no negative side effects, e.g., loss of data or thawing food, are incurred thereby. This motivates the use of appliance identification techniques, which determine the type of an attached appliance based on the continuous sampling of its power consumption. While various implementations based on different sampling resolutions have been presented in existing literature, the achievable classification accuracies have rarely been analyzed. We address this shortcoming and evaluate the accuracy of appliance identification based on the characteristic features of traces collected during the 24 hours of a day. We evaluate our algorithm using more than 1,000 traces of different electrical appliances' power consumptions. The results show that our approach can identify most of the appliances at high accuracy.
Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. (2009)

Our studies achieved successful formulation of curcumin loaded PLGA nanospheres, thus indicating that nanoparticle-based formulation of curcumin has high potential as an adjuvant therapy for clinical application in prostate cancer.
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. (2000)

Eighteen women with high-grade cervical or vulvar intraepithelial neoplasia who were positive for human papillomavirus (HPV) 16 and were HLA-A2 positive were treated with escalating doses of a vaccine consisting of a 9-amino acid peptide from amino acids 12-20 encoded by the E7 gene emulsified with incomplete Freund's adjuvant. Starting with the eleventh patient, an 8-amino acid peptide 86-93 linked to a helper T-cell epitope peptide with a covalently linked lipid tail was added. Patients with colposcopically and biopsy-proven cervical intraepithelial neoplasia/vulvar intraepithelial neoplasia II/III received four immunizations of increasing doses of the vaccine each 3 weeks apart, followed by a repeat colposcopy and definitive removal of dysplastic tissue 3 weeks after the fourth immunization. Patients were skin tested with the E7 12-20 peptide as well as control candida, mumps, and saline prior to and after the series of immunizations. Peripheral blood mononuclear cells were obtained by leucopheresis prior to and after the series of immunizations for analyses of CTL reactivity to the E7 12-20 and 86-93 epitope sequences. The presence of HPV 16 was assessed by DNA PCR on cervical scrapings and the biopsy specimens after vaccination. Pathology specimens were analyzed before and after vaccination for the presence of dysplasia, and the intralesional infiltrate of CD4/CD8 T-cells and dendritic cells was measured by immunohistochemical staining. Only 3 of 18 patients cleared their dysplasia after vaccine, but an increased S100+ dendritic cell infiltrate was observed in 6 of 6 patients tested. Cytokine release and cytolysis assays to measure E7-specific reactivity revealed increases in 10 of 16 patients tested. No positive delayed type hypersensitivity skin test reactivity was shown in any patient to HPV E7 12-20 before or after vaccinations. Virological assays showed that 12 of 18 patients cleared the virus from cervical scrapings by the fourth vaccine injection, but all biopsy samples were still positive by in situ RNA hybridization after vaccination. Six patients had partial colposcopically measured regression of their cervical intraepithelial neoplastic lesions in addition to the three complete responders. The data establish that a HPV-16 peptide vaccine may have important biological and clinical effects and suggest that future refinements of an HPV vaccine strategy to boost antigen-specific immunity should be explored.
Gain in ultra-low-threshold InAs/InGaAs quantum dot lasers (2002)

Semiconductor lasers are grown on a GaAs substrate by MBE containing self-assembled InAs quantum dots (QDs) in an InGaAs quantum well, the so-called dot-in-a-well (DWELL) structure. The QDs are /spl sim/15 nm in diameter in the basal plane and /spl sim/7 nm in height. Several wafers are investigated in detail. The in-plane dot density is either 2.5x10/sup 10/ or 7.5x10/sup 10/ cm/sup -2/. The ground-state emission wavelength is 1230-1250 nm at room temperature, and the spectral FWHM is from 40 to 75 nm. We obtained and analyzed the dependence of the gain on current density in ultra-low-threshold laser diodes with DWELL quantum-dot structures.
Template-Assisted Self-Assembly:  A Practical Route to Complex Aggregates of Monodispersed Colloids with Well-Defined Sizes, Shapes, and Structures (2001)

This paper describes a strategy that combines physical templating and capillary forces to assemble monodispersed spherical colloids into uniform aggregates with well-controlled sizes, shapes, and structures. When an aqueous dispersion of colloidal particles was allowed to dewet from a solid surface that had been patterned with appropriate relief structures, the particles were trapped by the recessed regions and assembled into aggregates whose structures were determined by the geometric confinement provided by the templates. We have demonstrated the capability and feasibility of this approach by assembling polystyrene beads and silica colloids (> or =150 nm in diameter) into complex aggregates that include polygonal or polyhedral clusters, linear or zigzag chains, and circular rings. We have also been able to generate hybrid aggregates in the shape of HF or H2O molecules that are composed of polymer beads having different diameters, polymer beads labeled with different organic dyes, and a combination of polymeric and inorganic beads. These colloidal aggregates can serve as a useful model system to investigate the hydrodynamic and optical scattering properties of colloidal particles having nonspherical morphologies. They should also find use as the building blocks to generate hierarchically self-assembled systems that may exhibit interesting properties highly valuable to areas ranging from photonics to condensed matter physics.
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression ofE. coli nitroreductase (2000)

The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that express nitroreductase become selectively sensitive to the prodrug CB1954. We have incorporated a nitroreductase expression cassette into a replication-defective adenovirus vector (Ad-CMV-ntr), which allowed efficient gene transfer to SK-OV-3 or IGROV-1 ovarian carcinoma cells. Nitroreductase levels increased in line with multiplicity of infection, and this was reflected in increasing sensitisation of the cells to CB1954, reaching an optimum (approx. 2, 000-fold sensitisation) with 25-50 p.f.u. per cell. Similar Ad-CMV-ntr-dependent sensitisation to CB1954 was seen in 3 of 6 low-passage primary ovarian tumour lines. Cells grown at low-serum concentration to inhibit proliferation remained equally susceptible to the Ad-CMV-ntr-dependent cytotoxicity of CB1954, indicating a distinct advantage over retroviral gene delivery and other popular enzyme-prodrug systems for human tumours with a low rate of cell proliferation. Additionally, cisplatin-resistant cells were sensitised towards CB1954 by Ad-CMV-ntr as efficiently as the parental cells, indicating that the system could be effective in patients with cisplatin-resistant tumours. In a murine xenograft model for disseminated peritoneal carcinomatosis with ascites, treatment of nude mice bearing intraperitoneal SUIT2 tumours with Ad-CMV-ntr and CB1954 almost doubled the median survival from 14 to 26 days (p < 0.0001).
Testosterone Levels in the Male Laboratory Rat: Variation under Experimental Conditions (1980)

This report describes the variation of testosterone (T) levels in male Wistar rats (250-300 g) bled under typical laboratory conditions. Plasma T in 114 rats ranged from 2-48 nmol/l (median 13.1; 95% confidence range, 10-15) and varied significantly (P < 0.01) during the day (07.30-16.30 h) with an acrophase between 09.00 h and 13.00 h. The distribution of plasma T levels was skewed (P < 0.05) and could be divided into basal values < 26 nmol/l and peaks > 26 nmol/l. Testosterone in testicular tissue and testis veins also varied during the day and was lower (P < 0.02) between 14.30 h and 16.30 h than from 11.30-13.30 h. It was shown that plasma T may differ significantly (P < 0.02) between groups (n = 6-7) of untreated rats bled under identical conditions and it is suggested that gonadotrophin stimulation be included in experimental designs to reduce the difficulty of differentiating between normal variability and treatment effects.
O asociacionismo español en Cuba, 1900-1930: o caso galego (1998)

"This article describes the comparison of the income distributions of Hungary and the Netherlands. In this comparison harmonised micro-data have been used to reach a high degree of comparability. The empirical results show that the inequality of household incomes was the same in both countries in the early eighties. After adjustments for differences in size and composition of households the income distribution was less equal in the Netherlands than in Hungary. The equivalence scales used were based on national budget surveys."
Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids (2010)

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are precursors of potent lipid mediators, termed eicosanoids, which play an important role in the regulation of inflammation. Eicosanoids derived from n-6 PUFAs (e.g., arachidonic acid) have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFAs [e.g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have anti-inflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived eicosanoids. While the typical Western diet has a much greater ratio of n-6 PUFAs compared with n-3 PUFAs, research has shown that by increasing the ratio of n-3 to n-6 fatty acids in the diet, and consequently favoring the production of EPA in the body, or by increasing the dietary intake of EPA and DHA through consumption of fatty fish or fish-oil supplements, reductions may be achieved in the incidence of many chronic diseases that involve inflammatory processes; most notably, these include cardiovascular diseases, inflammatory bowel disease (IBD), cancer, and rheumatoid arthritis, but psychiatric and neurodegenerative illnesses are other examples.
Extended DQRAP (XDQRAP). A cable TV protocol functioning as a distributed switch (2002)

XDQRAP, an extension of DQRAP (distributed Queueing Random Access protocol), is a multiple access protocol that like DQRAP offers a throughput equal to the offered traffic up to a load of one and with a lesser delay than any other multiple access protocol. XDQRAP, as does DQRAP, provides this performance for all values of "a", i.e., the size of the network is immaterial. XDQRAP also functions as a distributed switch in that the segments of variable length packets in a dotted system do not require encapsulation, i.e., an adaptation layer is not required. XDQRAP is described and simulation results are presented. The argument is presented that community networks should utilize random access of a shared medium on the inbound channel(s) at the MAC layer and that these community networks should utilize XDQRAP to support all voice and data transmission.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges (2014)

The tolerogenic cytokine IL9 promotes T regulatory cell function and allergic airway inflammation, but it has not been extensively studied in cancer. In this report, we used IL9-deficient mice to investigate the effects of IL9 in multiple models of breast and colon cancer development. Eliminating endogenous IL9 enabled sensitization of host T cells to tumors, leading to their early rejection without the requirement of vaccines or immunomodulatory therapies. Notably, IL9-deficient mice acquired immunologic memory, which actively protected from residual disease and tumor rechallenge, an effect linked to activation of CD8(+) T cells. Depletion of either CD8(+) or CD4(+) T cells abolished the benefits of IL9 loss to tumor control. Adoptive transfer experiments showed that T cells from tumor-rejecting IL9-deficient mice retained their effector competency in wild-type animals. Moreover, neutralizing IL9 antibody phenocopied the effects of IL9 gene deletion by slowing tumor progression in wild-type animals. Our results show the ability of IL9 to function as an inhibitor of adaptive immunity that prevents the formation of immunologic memory to a growing tumor, highlighting the potential for IL9 neutralization as a unique tool for cancer immunotherapy.
Encephalomyocarditis virus 3C protease: efficient cell-free expression from clones which link viral 5' noncoding sequences to the P3 region (1986)

All picornaviral peptides are derived by progressive posttranslational cleavage of a giant precursor polyprotein. Translation of encephalomyocarditis virus (EMC) RNA in rabbit reticulocyte extracts produces active viral peptides, including protease 3C, which is responsible for many cleavage reactions within the processing cascade. DNA plasmids containing 5' noncoding sequences of EMC linked to other portions of the viral genome were constructed and transcribed into RNA. Like virion RNA, the clone-derived transcripts directed efficient protein translation in vitro. The 5'-linked constructions may represent examples of a general method for cell-free expression of any cloned gene segment. One construction produced a self-cleaving P3 region precursor, which contained active 3C protease. A genetically engineered insertion within the 3C sequences eliminated endogenous self-cleavage activity without altering the ability of the P3 peptide to serve as substrate in bimolecular reactions with added 3C. Another plasmid encoding the L-VP0 portion of the capsid region was used to demonstrate that scission between the leader peptide (L) and capsid protein VP0 can be catalyzed by 3C. The enzyme responsible for this step was previously unidentified. A rapid purification scheme for isolation of 3C from EMC-infected HeLa cells is also presented.
The Maury Project, DataStreme Ocean, and Online Ocean Studies: AMS Initiatives in Ocean Science Education (2005)

The education program of the American Meteorological Society (AMS) has developed and nationally implemented two unique pre-college teacher enhancement programs on the ocean sciences, the Maury Project and DataStreme Ocean. In addition, the AMS has employed the successful DataStreme model to make available to colleges and universities an undergraduate distance-learning course on the fundamentals of oceanography, Online Ocean Studies. The Maury Project, established in 1994, is a partnership with the U.S. Naval Academy and State University of New York (SUNY) at Brockport, with significant support from the U.S. Navy, the National Oceanic and Atmospheric Administration (NOAA), and the National Science Foundation (NSF). The Maury Project trains and equips pre-college teachers to be peer trainers on the physical foundations of selected oceanographic topics. They are initially trained in a two-week workshop hosted by the U.S. Naval Academy. Subsequently, participating teachers present training sessions for other teachers with materials prepared by the Project. To date, approximately 300 educators have attended the workshop and tens of thousands of teachers have been peer trained. In 2003, with the goal of reaching a larger audience of pre-college teachers, the AMS in partnership with NOAA and SUNY Brockport initiated DataStreme Ocean. DataStreme Ocean is a semester-long distance-learning course on the basic understandings of oceanography and partially delivered via the Internet. Maury Project alumni work with local university and government laboratory scientists to mentor DataStreme Ocean participants. By fall 2005, over 600 teachers had been enrolled in DataStreme Ocean. Online Ocean Studies is a distance-learning introductory college-level course on the basic understandings of oceanography developed by the AMS in cooperation with NOAA. This semester-length course explores the ocean in the Earth system via investigations keyed to near real-time environmental data derived from ocean and coastal observing systems. Online Ocean Studies is a turnkey package (Web site, customized textbook, investigations manual, and secure faculty Web page) licensed from AMS and adaptable to both traditional lecture/laboratory and totally online local instruction. The AMS piloted Online Ocean Studies during spring 2005 with eleven participating colleges and universities. National implementation took place in fall 2005. Recently, the AMS embarked on a National Science Foundation-funded initiative to facilitate adoption of Online Ocean Studies by minority-serving institutions. The goal is to spur minority student interest in the geosciences.
Early Fixation of the Vertically Unstable Pelvis: The Role of Iliosacral Screw Fixation of the Posterior Lesion (1999)

Iliosacral screw fixation is a useful method of fixation in the vertically unstable pelvis but needs to be augmented by rigid anterior fixation to minimize malunion.
Changing Patterns of Transcriptional and Post-transcriptional Control of β-F1-ATPase Gene Expression during Mitochondrial Biogenesis in Liver (1995)

To elucidate the mechanisms that regulate the expression of nuclear genes during biogenesis of mammalian mitochondria, the expression pattern of the beta-subunit of the ATP synthase gene has been characterized in rat liver between day 20 in utero and 12 weeks postnatal. The parallelism existing between transcriptional activity of the gene and the amount of beta-F1-ATPase protein in liver indicates that proliferation of mitochondria is controlled at the transcriptional level. On the other hand, an increased stability (4-5-fold) of beta-F1-ATPase mRNA during early neonatal life as well as a rapid postnatal activation of translation rates affecting mitochondrial proteins appear to control mitochondrial differentiation. Immunoelectron microscopy of the F1-ATPase complex during liver development revealed that the rapid postnatal increase in the in vivo rate of F1-ATPase synthesis was mostly used for functional differentiation of pre-existing organelles (Valcarce, C., Navarrete, R. M., Encabo, P., Loeches, E., Satrústegui, J., and Cuezva, J. M. (1988) J. Biol Chem. 263, 7767-7775). The findings support that beta-F1-ATPase mRNA decay is developmentally regulated in liver, indicating that gene expression is also controlled at this level during physiological transitions that affect biogenesis of mitochondria.
Silk‐Based Conformal, Adhesive, Edible Food Sensors (2012)

An array of passive metamaterial antennas fabricated on all protein-based silk substrates were conformally transferred and adhered to the surface of an apple. This process allows the opportunity for intimate contact of micro- and nanostructures that can probe, and accordingly monitor changes in, their surrounding environment. This provides in situ monitoring of food quality. It is to be noted that this type of sensor consists of all edible and biodegradable components, holding utility and potential relevance for healthcare and food/consumer products and markets.
Lidocaine and muscimol microinjections in subthalamic nucleus reverse parkinsonian symptoms (2001)

Inactivation of neurones in the subthalamic nucleus (STN) of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated monkey model of Parkinson's disease has been shown to relieve parkinsonian motor symptoms. In patients with Parkinson's disease, neurones in the STN display hyperactive firing rates and rhythmic discharge activity such as tremor-related oscillations (3-8 Hz) and synchronous high-frequency oscillations (15-30 Hz). In this study, microinjections of lidocaine (n = 4) and muscimol, a GABA(A) receptor agonist (n = 2), were performed in the STN of six patients with Parkinson's disease to determine whether the focal suppression of STN neuronal activity can lead to an improvement in tremor, bradykinesia and rigidity. We also report the first use of microelectrode recording of the effects of microinjections on neuronal activity in the human brain (n = 2). Microinjections of 10-23 microl of lidocaine produced striking improvements in bradykinesia, limb tremor and rigidity in three out of three patients. These improvements were correlated with good therapeutic effects of subsequent STN deep brain stimulation performed in the same microelectrode trajectories as these injections. The most dramatic observation following lidocaine injections was the appearance of dyskinetic limb movements. In one patient, simultaneous microelectrode recording during an injection of 3.5 microl of lidocaine demonstrated a suppression of neuronal activity at distances of < 0.9 mm from the injection site, but no suppression was observed at > or = 1.2 mm from the injection site. Microinjections of 5-10 microl of muscimol in a region with tremor-related activity resulted in suppression of limb tremor in two out of two patients. Interestingly, in one of these patients, 4 Hz oscillatory activity was diminished in a neurone recorded 1.3 mm from the injection site, but there was no reduction in the mean firing rate or 20 Hz oscillatory activity. These results demonstrate that inactivation of neuronal activity in the STN of patients with Parkinson's disease improves motor symptoms. These findings also suggest that a focal block of the STN might alter the oscillatory activity of neurones located beyond the inhibited region.
Multidimensional comparison of shot detection algorithms (2003)

Shot change detection in video sequences mainly involves two tasks: a numeric evaluation of the degree of disparity between temporally related frames, and deciding whether a value or a series of values of that disparity is or is not a shot change. This paper focuses on the first task, and presents a methodology for comparison between different criteria to evaluate disparity between frames. The main innovation respect to other comparative studies, is that it allows a multidimensional comparative analysis based on the simultaneous consideration of several criteria. In order to overcome the problems inherent to a multidimensional approach, this method is independent of any decision process, and evaluates the performance of every criterion or set of criteria via a process that results in the obtaining of a. single numerical value, which allows an extensive study and a clear and straightforward analysis of the comparative possibilities of each technique.