gebhart/patrepeval huggingface dataset:
A compact eyetracked optical see-through head-mounted display (2012)

An eye-tracked head-mounted display (ET-HMD) system is able to display virtual images as a classical HMD does, while additionally tracking the gaze direction of the user. There is ample evidence that a fully-integrated ETHMD system offers multi-fold benefits, not only to fundamental scientific research but also to emerging applications of such technology. For instance eyetracking capability in HMDs adds a very valuable tool and objective metric for scientists to quantitatively assess user interaction with 3D environments and investigate the effectiveness of various 3D visualization technologies for various specific tasks including training, education, and augmented cognition tasks. In this paper, we present an innovative optical approach to the design of an optical see-through ET-HMD system based on freeform optical technology and an innovative optical scheme that uniquely combines the display optics with the eye imaging optics. A preliminary design of the described ET-HMD system will be presented.
Neuropeptide Y receptor in the rat brain (1984)

The specific binding of the chloramine-T iodinated neuropeptide Y (125I-NPY) to membranes from rat cerebral cortex was investigated using equilibrium binding and kinetic methods. The equilibrium binding of 125I-NPY at 37 degrees C was characterized by a Kd value of 0.38 nM. The receptor densities in the cerebral cortex, hypothalamus and cerebellum were 0.45 pmol/mg, 0.47 pmol/mg and 0.04 pmol/mg protein respectively. The binding site for 125I-NPY was sensitive to treatment with proteolytic enzymes and thiol reagents. The binding showed a sharp optimum at pH 7-7.7 and was inhibited by increasing concentrations of Mg2+.
SCORM-MPEG: An ontology of interoperable metadata for multimedia and e-Learning (2015)

The convergence of digital media offers an integration of ICT focused on telecommunications and multimedia domain (under responsibility of the Moving Picture Experts Group, ISO/IEC JTC1 SC29) and the ICTE (the ICT for Education), managed by the ISO/IEC JTC1 SC36, highlighting the MPEG standards, employees as content and metadata to the multimedia Digital TV and the technologies applied to e-Learning. Regarding this, there is the problem of developing an interoperable matching for normative bases, achieving an innovative proposal in the convergence between digital telecommunications and applications for e-Learning, also essentially multimedia. To reach this purpose it is proposed to create a standard ontology of interoperable metadata for web, digital TV and extensions for mobile devices based on the integration between MPEG-21 and SCORM metadata standards. The methodology used consists on building an ontology MPEG-21 SCORM which can be achieved on making a correspondence through the XPath language, managed by the W3C. The employ of the XPath language is desirable for matching and mapping both metadata schema patterns - integrating MPEG-21 (mostly Digital Item Declaration Language) and SCORM metadata schema. The practical purpose is the creation and storage of objects for use in digital telecommunications as Digital Television, in an interoperable way with the e-Learning industry, here as description metadata for all sorts of media and hypermedia to create learning objects.
Semiconductor Hetero- and Nanostructures (2001)

In this thesis, chemical beam epitaxy was used to fabricate nm-sized crystalline structures. Most of the systems were based on heterostructures, i.e., combinations of different kinds of crystalline materials. One-dimensional quantum structures were investigated in two systems, the Stranski-Krastanow grown horizontal GaAs wires on GaP substrates, and the Vapour-Liquid-Solid grown vertical GaAs and InAs nanowhiskers. In addition, the heterostructural interface between GaP and a Si substrate was optimized and investigated. The strain-induced formation of horizontal GaAs quantum wires was studied with atomic force microscope and in situ electron diffraction. The density of the wires could be varied from single, monolithic elongted islands transforming into a corrugated surface. The critical occurrence of anti-phase domain related defects in the growth of heteroepitaxial GaP on Si has been approached. The influence of surface orientation and the selective growth on atomicaly flat sub-µm Si areas have been investigated, resulting in succesful fabrication of defect free GaP nanocrystals. In this system, 200 µm wide pn-junctions containing a heterointerface were fabricated. Semiconductor nanowhiskers have been investigated for InAs and GaAs, with the focus on control of size, position, density and growth rate of the whiskers. Hetereostructures containing InAs and GaAs segments in nanowhiskers have also been pursued.
Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines (1996)

Accessory cell-surface molecules involved in the entry of human immunodeficiency virus-type 1 into cells have recently been identified and shown to belong to the family of chemokine receptors. Treatment of human cell lines with soluble monomeric gp120 at 37 degrees C induced an association between the surface CD4-gp120 complex and a 45-kilodalton protein, which can be down-modulated by the phorbol ester phorbol 12-myristate 13-acetate. The three proteins were coprecipitated from the cell membranes with antibodies to CD4 or to gp120. The 45-kilodalton protein comigrated with fusin on sodium dodecyl sulfate gels and reacted with rabbit antisera to fusin in protein immunoblots. No 45-kilodalton protein could be coprecipitated from similarly treated nonhuman cells. However, infection of 3T3.CD4.401 cells with vaccinia-fusin recombinant virus (vCBYF1), followed by gp120 treatment, resulted in coprecipitation of fusin and CD4.401 molecules from their membranes. Together these data provide evidence for physical association between fusin and the CD4-gp120 complex on cell membranes.
Coagulation assessment by rotation thrombelastometry in normal pregnancy (2009)

We analysed changes in coagulation during normal pregnancy with a novel point-of-care device based on thrombelastometry (ROTEM). We compared the results obtained with those of standard coagulation tests in 104 patients: 20 non-pregnant women (controls) and 84 women in the first (T1, n = 17), second (T2, n = 9) and third (T3, n = 58) trimesters of pregnancy. We measured the clotting time (CT), the maximum clot firmness (MCF), the early clot amplitude at 5 and 15 minutes (CA(5), CA(15)) and the clot lysis index (CLI(30)) with four tests containing specific reagents. (a) The INTEM test involving ellagic acid activated the intrinsic pathway and (b) the EXTEM test using tissue factor triggered the extrinsic pathway; (c) The FIBTEM test based on a platelet inhibitor (cytochalasin D) evaluated the contribution of fibrinogen to clot formation and (d) the APTEM test was similar to the EXTEM but was based on inhibition in vitro of fibrinolysis by aprotinin. CT and CLI(30) were not significantly modified during pregnancy whereas MCF, CA(5) and CA(15) (INTEM, EXTEM, FIBTEM) increased significantly between the second and third trimesters (e.g. median [interquartile range]: MCF-FIBTEM, 13 [11-16] mm vs. 19 [17-23] mm, respectively, in controls and T3, p < 0.001). EXTEM values were not significantly different from those measured with APTEM. There were significant correlations between the results obtained with ROTEM and those from standard coagulation tests. ROTEM analysis showed a marked increase in coagulability during normal pregnancy. ROTEM values may serve as the basis for future studies in pregnant women.
A chemical probe technique for the determination of reactive halogen species in aqueous solution: Part 1 – bromide solutions (2006)

Abstract. Reactive halogen species (X*=X•, •X2-, X2 and HOX, where X=Br, Cl, or I) in seawater, sea-salt particles, and snowpacks play important roles in the chemistry of the marine boundary layer. Despite this, relatively little is known about the steady-state concentrations or kinetics of reactive halogens in these environmental samples. In part this is because there are few instruments or techniques that can be used to characterize aqueous reactive halogens. To better understand this chemistry, we have developed a chemical probe technique that can detect and quantify aqueous reactive bromine and chlorine species (Br*(aq) and Cl*(aq)). This technique is based on the reactions of short-lived X*(aq) species with allyl alcohol (CH2=CHCH2OH) to form stable 3-halo-1,2-propanediols that are analyzed by gas chromatography. Using this technique in conjunction with competition kinetics allows determination of the steady state concentrations of the aqueous reactive halogens and, in some cases, the rates of formation and lifetimes of X* in aqueous solutions. We report here the results of the method development for aqueous solutions containing only bromide (Br-).
Biologic markers in endometrial cancer treatment (2009)

With a lifetime risk among women of 2-3%, endometrial cancer is the most common pelvic gynecologic malignancy in industrialized countries. Approximately 75% of cases are diagnosed at an early stage with a tumor confined to the uterine corpus. Although most patients are cured by surgery alone, about 15-20% with no signs of locally advanced or metastatic disease at primary treatment recurs, with limited responsiveness to systemic therapy. The most common basis for determining the risk of recurrent disease has been classification of endometrial cancers into two subtypes. Type I, associated with a good prognosis, accounts for the majority of cases and is associated with a low-stage, low-grade and endometrioid histology. In contrast, type II, associated with a poor prognosis, is characterized by a high-stage, high-grade and non-endometrioid histology. However, the prognostic value of this distinction is limited, as up to 20% of type I endometrial cancers recur, while half of type II cancers do not. We review the current literature on epidemiology, etiology, pathology, molecular alterations, staging, treatment and prognostic factors in endometrial cancer. Ongoing molecular-based clinical trials and newly reported molecular alterations with a potential for development of new targeted therapy are discussed.
Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus (1987)

Human cytomegalovirus contains a phosphorylated matrix protein of 65,000 apparent molecular weight (65K phosphoprotein; pp65) and a related phosphoprotein of 71,000 molecular weight (pp71). The 65K phosphoprotein is usually by far the most abundant structural component found in culture-grown purified virus particles. This study describes the precise mapping of the genes for both polypeptides, giving the entire nucleotide sequences and the exact positions of the respective transcripts. The 65K phosphoprotein is coded for by the 5'-terminal part of an abundant 4-kilobase (kb) mRNA. The 71K phosphoprotein corresponds to the single translational reading frame of a rare nonspliced 1.9-kb mRNA that is coterminal with the 4-kb transcript. The promoter for 4-kb mRNA appears to be unusual in structure; it does not contain a characteristic TATA sequence. The expression of antigenic epitopes from pp65 may allow improved serodiagnosis of human cytomegalovirus infections.
Rapid reversal of alpha 2‐adrenoceptor agonist effects by atipamezole in human volunteers. (1991)

1. The ability of atipamezole, a specific and selective alpha 2-adrenoceptor antagonist, to reverse the pharmacological effects induced by the alpha 2-adrenoceptor agonist dexmedetomidine was studied in six healthy male volunteers. Each volunteer received in four sessions in a randomized and single-blind manner three different doses (6.7 micrograms kg-1, 27 micrograms kg-1 and 67 micrograms kg-1) of atipamezole or saline placebo as 5 min i.v. infusions preceded by a fixed i.v. dose of dexmedetomidine (0.67 micrograms kg-1). 2. Dexmedetomidine caused profound sedation, with the subjects actually falling asleep. This was effectively reversed by the two highest doses of antipamezole. 3. Dexmedetomidine reduced salivary flow on average by 70%. A rapid and full reversal of this effect was seen after the highest dose of antipamezole. 4. Hypotension induced by dexmedetomidine was also effectively antagonized by atipamezole. Bradycardia was very modest after dexmedetomidine in this study, and thus no reversal of alpha 2-adrenoceptor agonist-induced bradycardia could be demonstrated. 5. Plasma noradrenaline concentrations were reduced by 80% by dexmedetomidine. This was effectively antagonized by atipamezole, and the highest dose caused a 50% overshoot in plasma noradrenaline concentrations over the basal levels. 6. It is concluded that the effects of dexmedetomidine are effectively reversible by atipamezole. A dose ratio of 10:1 for atipamezole:dexmedetomidine was clearly insufficient for this purpose, but ratios in the range of 40:1 to 100:1 were found to be effective in the current experimental situation.
Properties and Derivatives of α-Lipoic Acid (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties and Derivatives of α-Lipoic AcidArthur F. Wagner, Edward Walton, George E. Boxer, Myron P. Pruss, Frederick W. Holly, and Karl FolkersCite this: J. Am. Chem. Soc. 1956, 78, 19, 5079–5081Publication Date (Print):October 1, 1956Publication History Published online1 May 2002Published inissue 1 October 1956https://pubs.acs.org/doi/10.1021/ja01600a069https://doi.org/10.1021/ja01600a069research-articleACS PublicationsRequest reuse permissionsArticle Views1249Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computational techniques for fast hyperthermia temperature optimization (1999)

Hyperthermia temperature optimization involves arriving at a temperature distribution which minimizes a stated goal function, the goal function having a biological basis in maximizing tumor cell kill while not exceeding normal tissue toxicity. This involves the computationally intensive process of multiple evaluations of the temperature goal function, requiring repeated evaluations of the power deposition and its corresponding temperature distribution. Two computational schemes are proposed to expedite the temperature optimization process: (1) temperature distribution evaluation by superpositioning precomputed distributions, and (2) using representative tissue groups (rather than every point in the domain) to evaluate the goal function. The application of these schemes is illustrated with a typical optimization problem, as applied to symmetric and asymmetric, heterogeneous models. Application of these schemes reduced the optimization time on a DEC Alpha 1000 4/266 (Alpha is a registered trademark of Digital Equipment Corporation.) from several h to min, with little difference in results. The computational schemes, though demonstrated in the context of electromagnetic hyperthermia, are generally applicable to other forms of nonionizing radiation employed in hyperthermia therapy.
Laser Detection of Pollution (1978)

Spectroscopic analysis is a useful technique for identifying and quantitatively determining the presence of specific gaseous constituents. Development of high-power tunable lasers has made the spectroscopic technique for detection of trace constituents in the atmosphere very attractive for practical applications. In this article three of the currently used modes for laser detection of pollution are reviewed: (i) long-path measurements, (ii) laser Raman (differential absorption) measurements, and (iii) optoacoustic detection. Progress in the field has been extremely rapid in the last few years and very useful and reliable data on air pollution can now be obtained routinely with the techniques described.
Purification and characterization of a lipopeptide produced by Bacillus thuringiensis CMB26 (2004)

Compared with surfactin and iturin, the lipopeptide from B. thuringiensis CMB26 showed stronger antifungal activity against phytopathogenic fungi. This lipopeptide is a candidate for the biocontrol of pathogens in agriculture.
Immunoradiometric Assay of Thyroglobulin in Patients with Differentiated Thyroid Carcinomas: Need for Thyroglobulin Recovery Tests (1998)

As interference from thyroglobulin autoantibodies appears to have been overcome in new commercial thyroglobulin assays by the use of monoclonal antibodies, the need for thyroglobulin recovery tests became uncertain. Sera (n=45) from patients with differentiated thyroid carcinomas were selected on the basis of a thyroglobulin recovery value below 70% in the Dynotest Tg immunoradiometric assay (Brahms) routinely used in our laboratory. Serum thyroglobulin levels were then measured using three other commercial immunoradiometric assays: thyroglobulin ERIA (Pasteur), HTGK (Sorin) and ELSA HTG (Cis Bio International). Thyroglobulin autoantibodies were measured using the Thyrak assay (Brahms). Although many patients were thyroglobulin antibodies-negative (< 200 U/ml, n=26), most immunoradiometric assays failed to detect thyroglobulin in patients with evidence of recurrence. Low thyroglobulin values associated with low thyroglobulin recovery in thyroglobulin antibody-negative patients appear to be more biologically relevant than a single low thyroglobulin value, which can lead to lack of medical intervention. We conclude that the thyroglobulin recovery test is a prerequisite for the correct interpretation of serum thyroglobulin levels determined with immunoradiometric assays in the follow-up of thyroglobulin autoantibody-negative patients treated for differentiated thyroid carcinomas.
Learning Nature's Way: Biosensing with Synthetic Nanopores (2007)

Synthetic sensors use molecular recognition events in nanometer-scale pores for selective detection of proteins, nucleotides, and drugs.
Location-based data raise ethical issues for cultural heritage (2019)

AAAS issues guidelines for scientists, volunteers, and others increasingly using such data
Structure−Activity Relationships for Substrate-Based Inhibitors of Human Complement Factor B (2009)

Human complement is a cascading network of plasma proteins important in immune defense, cooperatively effecting recognition, opsonization, destruction, and removal of pathogens and infected/damaged cells. Overstimulated or unregulated complement activation can result in immunoinflammatory diseases. Key serine proteases in this cascade are difficult to study due to their multiprotein composition, short lifetimes, formation on membranes, or serum circulation as inactive zymogens. Factor B is inactive at pH 7, but a catalytically active serine protease under alkaline conditions, enabling structure-activity relationship studies for 63 substrate-based peptide inhibitors with 4-7 residues and a C-terminal aldehyde. A potent factor B inhibitor was hexpeptide Ac-RLTbaLAR-H (IC(50) 250 nM, pH 9.5), which at pH 7 also blocked formation of membrane attack complex via the "alternative pathway" of complement activation and inhibited human complement mediated lysis of rabbit erythrocytes. Inhibitors of factor B may be valuable probes and drug leads for complement mediated immunity and disease.
Human recombinant insulin and amyloidosis: an unexpected association. (2010)

A 48-year-old patient with diabetes mellitus was treated with human (recombinant) insulin. He developed cutaneous amyloidosis twice at different locations where subcutaneous insulin had been injected. There were no signs of systemic amyloidosis. Additional pathological-anatomical investigations demonstrated insulin in one (the most recent) amyloid tumour. A limited number of similar cases have been reported in the literature, although mostly associated with porcine insulin. Cutaneous amyloidosis may be associated with local injections of human (recombinant) insulin. One should therefore also consider this diagnosis when finding tumours at sites where insulin has been injected.
Erectile function after radical prostatectomy. (2000)

The early detection of prostate cancer through the use of prostate-specific antigen screening has resulted in the performance of many more radical prostatectomy procedures as a curative treatment for this disease. Many patients who are candidates for this procedure already suffer from erectile dysfunction, and the incidence of inadequate erections following radical prostatectomy is certainly high. Nerve-sparing procedures during performance of this operation are encouraged as the incidence of erectile dysfunction is lower if one or both nerves are spared. If the patient is already impotent before the procedure, medical treatments with oral agents, intraurethral compounds, or intracorporally injected medications may be more effective with the nerves intact. Early institution of medical therapy, specifically intracorporal injections, after 2 months postoperatively has resulted in a higher incidence of spontaneous return of erections at 1 year. Vacuum erection devices may be successful in restoring erections but extensive practice in their use is necessary, and they may be unappealing to many patients. A penile prosthesis will restore erections if the patient is so motivated for implantation of such a device. These are expensive and require invasive surgery, but satisfaction rates among patients and partners who have used them have been in the range of 85%, the highest satisfaction rate among all of the treatments of erectile dysfunction.
End-to-end QoS provisioning in mobile heterogeneous networks (2004)

The remarkable advances in information technologies bring a heterogeneous environment for mobile users and service providers. This heterogeneity exists in wireless access technologies, networks, user terminals, applications, service providers, and so on. The ability to provide seamless and adaptive quality of service in such a heterogeneous environment is key to the success of next-generation wireless communications systems. There has been a considerable amount of QoS research recently. However, the main part of this research has been in the context of individual architectural components, and much less progress has been made in addressing the issue of an overall QoS architecture for the mobile Internet. This article first summarizes the state-of-the-art QoS techniques and standardization activities, then examines in detail important challenges in building a ubiquitous QoS framework over the heterogeneous environment, and finally proposes a QoS framework integrating a three-plane network infrastructure and a unified terminal cross-layer adaptation platform to provide seamless support for future applications.