gebhart/patrepeval huggingface dataset:
Planar integrated magnetics design in wide input range DC-DC converter for fuel cell application (2010)

In the most power electronics converters, the overall volume is mainly determined by the number of parts and the size of passive components. Integrated magnetics and planar magnetics techniques therefore have been an excellent option in order to reduce the count and the size of magnetic components, hereby increasing the power density of converters. A new planar integrated magnetics (PIM) technique for a phase-shift plus duty cycle controlled hybrid bi-directional DC/DC converter is presented and investigated in this paper. The main magnetic components including one boost inductor and two independent transformers are integrated into an E-I-E core geometry. Utilizing the flux cancellation as the principle of uncoupling, the transformers and the boost inductor are integrated, to reduce the total ferrite volume and core loss. The transformers and inductor are wound in the outer legs and the center legs respectively. The uncoupling effect between them is determined by the winding connections. The middle I-core provides a shared low reluctance flux path, uncoupling the two independent transformers. With the air gaps shift into the center legs, the magnetizing inductance of transformers will not be decreased due to there is no air gap throughout the flux paths generated by the two transformers. The new PIM structure can be extended to other topologies. To verify the validity of design approach and theoretical analysis, a lab prototype with PIM has been built, and tested. Comparing with the discrete structure, the result demonstrated a great improvement in profile and volume without sacrificing electrical performance.
Name-it: naming and detecting faces in video by the integration of image and natural language processing (1997)

We have been developing Name-It, a system that associates faces and names in news videos. First, as the only knowledge source, the system is given news videos which include image sequences and transcripts obtained from audio tracks or closed caption texts. The system can then either infer the name of a given face and output the name candidates, or can locate the faces in news videos by a name. To accomplish this task, the system extracts faces from image sequences and names from transcripts, both of which might correspond to key persons in news topics. The proposed system takes full advantage of advanced image and natural language processing. The image processing contributes to the extraction of face sequences which provide rich information for face-name association. The processing also helps to select the best frontal view of a face in a face sequence to enhance the face identification which is required for the processing. On the other hand, the natural language processing effectively...
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain (2003)

Botulinum toxin type A (BoNT-A) produced by the bacterium Clostridium botulinum is a potent inhibitor of acetylcholine release in the neuromuscular junction and has been used to treat many disorders related to excessive muscle contraction. However, BoNT-A has recently been used in pain therapy to treat myofascial pain, low back pain and various types of headaches, including migraine. The purpose of this study is to investigate the antinociceptive effect of BoNT-A and its underlying mechanism in the rat formalin inflammatory pain model. BoNT-A (3.5, 7, 15 and 30 U/kg) or vehicle was administered to the plantar surface of the right hindpaw of male Sprague-Dawley rats. BoNT-A dose-dependently (P<0.05) inhibited formalin-induced nociceptive behavior during phase 2 but not during phase 1 when administered 5 h to 12 days before formalin challenge. The onset of the antinociceptive effect started at 5 h after pre-treatment and this effect lasted for at least 12 days. BoNT-A (7 U/kg) also reduced edema. Consistent with the lack of effect in the formalin phase 1, BoNT-A, at 15 U/kg, had no effect on acute thermal nociception; no local muscle weakness was observed at this dose. Pre-treatment of rats with BoNT-A (3.5, 7 or 15 U/kg) all significantly reduced formalin-evoked glutamate (Glu) release. These results demonstrate that local peripheral injection of BoNT-A significantly reduces formalin-induced nociceptive behaviors with the absence of obvious muscle weakness. Such an antinociceptive effect of BoNT-A is associated with the inhibition of formalin-induced release of Glu (and/or neuropeptides) from primary afferent terminals.
A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. (2010)

A substantial amount of research has been conducted in an effort to understand the impact of short-term (<48 hr) total sleep deprivation (SD) on outcomes in various cognitive domains. Despite this wealth of information, there has been disagreement on how these data should be interpreted, arising in part because the relative magnitude of effect sizes in these domains is not known. To address this question, we conducted a meta-analysis to discover the effects of short-term SD on both speed and accuracy measures in 6 cognitive categories: simple attention, complex attention, working memory, processing speed, short-term memory, and reasoning. Seventy articles containing 147 cognitive tests were found that met inclusion criteria for this study. Effect sizes ranged from small and nonsignificant (reasoning accuracy: g = -0.125, 95% CI [-0.27, 0.02]) to large (lapses in simple attention: g = -0.776, 95% CI [-0.96, -0.60], p < .001). Across cognitive domains, significant differences were observed for both speed and accuracy; however, there were no differences between speed and accuracy measures within each cognitive domain. Of several moderators tested, only time awake was a significant predictor of between-studies variability, and only for accuracy measures, suggesting that heterogeneity in test characteristics may account for a significant amount of the remaining between-studies variance. The theoretical implications of these findings for the study of SD and cognition are discussed.
Mass spectrometric identification of oxidative modifications of tryptophan residues in proteins: Chemical artifact or post-translational modification? (2010)

Oxidative modification of tryptophan to kynurenine (KYN) and N-formyl kynurenine (NFK) has been described in mitochondrial proteins associated with redox metabolism, and in human cataract lenses. To a large extent, however, previously reported identifications of these modifications were performed using peptide mass fingerprinting and/or tandem-MS data of proteins separated by gel electrophoresis. To date, it is uncertain whether NFK and KYN may represent sample handling artifacts or exclusively post-translational events. To address the problem of the origin of tryptophan oxidation, we characterized several antibodies by liquid chromatography-tandem mass spectrometry, with and without the use of electrophoretic separation of heavy and light chains. Antibodies are not normally expected to undergo oxidative modifications, however, several tryptophan (Trp) residues on both heavy and light chains were found extensively modified to both doubly oxidized Trp and KYN following SDS-PAGE separation and in-gel digestion. In contrast, those residues were observed as non-modified upon in-solution digestion. These results indicate that Trp oxidation may occur as an artifact in proteins separated by SDS-PAGE, and their presence should be carefully interpreted, especially when gel electrophoretic separation methods are employed.
Fine needle aspiration minibiopsies. (1986)

During a five-and-one-half-year period, cell buttons were prepared from 393 (29%) of 1,375 fine needle aspirates. Of these, 237 were diagnostically helpful and confirmatory in conjunction with the smears. In 103 (7% of all cases), the tissue fragments in the cell button allowed a definite diagnosis or classification of the tumor that otherwise would not have been possible. The architecture that is often preserved in these minibiopsies is identical to that seen in larger tissue samples. The specimens lend themselves well to special histochemical and electron microscopic studies. Wider use of this established and simple procedure is encouraged.
Seizures and cerebral infarction in the full‐term newborn (1985)

Cerebral arterial infarction is a more common cause of neonatal seizures than has been previously appreciated. In 50 full-term newborns with seizures studied, 7 had cerebral infarction which was the second most common definable cause of seizures. We describe these 7 full-term infants with cerebrovascular accidents who presented with focal or generalized seizures. Obstetrical histories were normal in 5 of these patients. Their neurological examinations demonstrated lethargy and generalized hypotonia. Electroencephalograms demonstrated focal abnormalities in 4 infants. Computed tomographic scans in the first week of life showed infarctions in 6 newborns and in another at age 6 months. Neonatal stroke should be considered as a cause of seizures in a full-term newborn in spite of a normal obstetrical history and a nonfocal neurological examination.
A Statistical Model for Indoor Multipath Propagation (1987)

The results of indoor multipath propagation measurements using 10 ns, 1.5 GHz, radarlike pulses are presented for a medium-size office building. The observed channel was very slowly time varying, with the delay spread extending over a range up to about 200 ns and rms values of up to about 50 ns. The attenuation varied over a 60 dB dynamic range. A simple statistical multipath model of the indoor radio channel is also presented, which fits our measurements well, and more importantly, appears to be extendable to other buildings. With this model, the received signal rays arrive in clusters. The rays have independent uniform phases, and independent Rayleigh amplitudes with variances that decay exponentially with cluster and ray delays. The clusters, and the rays within the cluster, form Poisson arrival processes with different, but fixed, rates. The clusters are formed by the building superstructure, while the individual rays are formed by objects in the vicinities of the transmitter and the receiver.
Identification of a Cytolethal Distending Toxin Gene Locus and Features of a Virulence-Associated Region inActinobacillus actinomycetemcomitans (1999)

A genetic locus for a cytolethal distending toxin (CDT) was identified in a polymorphic region of the chromosome of Actinobacillus actinomycetemcomitans, a predominant oral pathogen. The locus was comprised of three open reading frames (ORFs) that had significant amino acid sequence similarity and more than 90% sequence identity to the cdtABC genes of some pathogenic Escherichia coli strains and Haemophilus ducreyi, respectively. Sonic extracts from recombinant E. coli, containing the A. actinomycetemcomitans ORFs, caused the distension and killing of Chinese hamster ovary cells characteristic of a CDT. Monoclonal antibodies made reactive with the CdtA, CdtB, and CdtC proteins of H. ducreyi recognized the corresponding gene products from the recombinant strain. CDT-like activities were no longer expressed by the recombinant strain when an OmegaKan-2 interposon was inserted into the cdtA and cdtB genes. Expression of the CDT-like activities in A. actinomycetemcomitans was strain specific. Naturally occurring expression-negative strains had large deletions within the region of the cdt locus. The cdtABC genes were flanked by an ORF (virulence plasmid protein), a partial ORF (integrase), and DNA sequences (bacteriophage integration site) characteristic of virulence-associated regions. These results provide evidence for a functional CDT in a human oral pathogen.
Agrobacterium-Mediated Transformation of Soft Fruit Rubus, Ribes, and Fragaria (2003)

Gene transfer technology is particularly useful for fruit crops where breeders are faced with long generation times because of the relatively long periods of juvenility associated with perennial plants. Also, the highly heterozygous nature of the germplasm requires the evaluation of large seedling populations and maintenance of the genotype by vegetative propagation.
Blockade of VEGFR2 and Not VEGFR1 Can Limit Diet-Induced Fat Tissue Expansion: Role of Local versus Bone Marrow-Derived Endothelial Cells (2009)

Formation of new vessels in fat tissues during DIO is largely due to angiogenesis rather than de novo vasculogenesis. Antiangiogenic treatment by blockade of VEGFR2 but not VEGFR1 may limit adipose tissue expansion.
Experimental method for the measurement of the elastic modulus of trabecular bone tissue (1989)

A procedure has been developed to measure the elastic modulus of small, irregularly shaped specimens without significantly disturbing the specimen's internal or surface structure. This procedure was developed to measure the average elastic modulus of isolated trabeculae from human cancellous bone tissue. The procedure combines direct testing of a cantilever beam-type specimen, along with finite element modeling of the specimen and the testing conditions. Initial estimates for the bone tissue material properties are input into the finite element model; differences between the calculated finite element displacement and the experimentally observed displacement allows the actual material modulus to be determined. Machined aluminum and cortical bone specimens were used to test the accuracy and repeatability of the procedure. Manipulations of the finite element models were performed to examine the effect that mesh construction errors might have on the accuracy of the results. None of the parameters examined resulted in changes in the measured finite element displacements of greater than 8%. In tests on six trabecular bone specimens, an average elastic modulus of 7.8 GPa was calculated. Even taking into account the possible sources of error, this value remains significantly less than the accepted value for cortical bone.
New treatment options in intermittent claudication: the US experience. (2001)

The goals of treatment in intermittent claudication are to modify cardiovascular risk factors and to reduce claudication pain, increase walking distance and improve quality of life. Walking distance in intermittent claudication can be improved both by exercise rehabilitation and by pharmacological treatments. At present, the only two drugs licensed in the US for the treatment of claudication symptoms are oxpentifylline and cilostazol. Although oxpentifylline has been shown to increase maximal and pain-free walking distance in a number of trials, other studies call its efficacy into question. Eight double-blind, placebo-controlled trials have established that cilostazol improves both maximal and pain-free walking distance in patients with moderate to severe intermittent claudication, with highly statistically significant differences compared with placebo. Cilostazol has also been shown to improve the physical dimensions of quality of life. Naftidrofuryl is licensed for the treatment of intermittent claudication in Europe, but not in the US. Some clinical trials have shown it to be effective in treating intermittent claudication. Promising new agents in the treatment of intermittent claudication include L-arginine, propionyl-L-carnitine, prostaglandins, and angiogenic growth factors such as vascular endothelial growth factor and basic fibroblast growth factor.
Novel Multiplex MethyLight Protocol for Detection of DNA Methylation in Patient Tissues and Bodily Fluids (2014)

Aberrant DNA methylation is a hallmark of cancer and is an important potential biomarker. Particularly, combined analysis of a panel of hypermethylated genes shows the most promising clinical performance. Herein, we developed, optimized and standardized a multiplex MethyLight assay to simultaneously detect hypermethylation of APC, HOXD3 and TGFB2 in DNA extracted from prostate cancer (PCa) cell lines, archival tissue specimens, and urine samples. We established that the assay is capable of discriminating between fully methylated and unmethylated alleles with 100% specificity and demonstrated the assay as highly accurate and reproducible as the singleplex approach. For proof of principle, we analyzed the methylation status of these genes in tissue and urine samples of PCa patients as well as PCa-free controls. These data show that the multiplex MethyLight assay offers a significant advantage when working with limited quantities of DNA and has potential applications in research and clinical settings.
QuaDRiGa: A 3-D Multi-Cell Channel Model With Time Evolution for Enabling Virtual Field Trials (2014)

Channel models are important tools to evaluate the performance of new concepts in mobile communications. However, there is a tradeoff between complexity and accuracy. In this paper, we extend the popular Wireless World Initiative for New Radio (WINNER) channel model with new features to make it as realistic as possible. Our approach enables more realistic evaluation results at an early stage of algorithm development. The new model supports 3-D propagation, 3-D antenna patterns, time evolving channel traces of arbitrary length, scenario transitions and variable terminal speeds. We validated the model by measurements in a coherent LTE advanced testbed in downtown Berlin, Germany. We then reproduced the same scenario in the model and compared several channel parameters (delay spread, path gain, K-factor, geometry factor and capacity). The results match very well and we can accurately predict the performance for an urban macro-cell setup with commercial high-gain antennas. At the same time, the computational complexity does not increase significantly and we can use all existing WINNER parameter tables. These artificial channels, having equivalent characteristics as measured data, enable virtual field trials long before prototypes are available.
A Survey of Machine Learning Techniques Applied to Software Defined Networking (SDN): Research Issues and Challenges (2018)

In recent years, with the rapid development of current Internet and mobile communication technologies, the infrastructure, devices and resources in networking systems are becoming more complex and heterogeneous. In order to efficiently organize, manage, maintain and optimize networking systems, more intelligence needs to be deployed. However, due to the inherently distributed feature of traditional networks, machine learning techniques are hard to be applied and deployed to control and operate networks. Software defined networking (SDN) brings us new chances to provide intelligence inside the networks. The capabilities of SDN (e.g., logically centralized control, global view of the network, software-based traffic analysis, and dynamic updating of forwarding rules) make it easier to apply machine learning techniques. In this paper, we provide a comprehensive survey on the literature involving machine learning algorithms applied to SDN. First, the related works and background knowledge are introduced. Then, we present an overview of machine learning algorithms. In addition, we review how machine learning algorithms are applied in the realm of SDN, from the perspective of traffic classification, routing optimization, quality of service/quality of experience prediction, resource management and security. Finally, challenges and broader perspectives are discussed.
MethPrimer: designing primers for methylation PCRs (2002)

MethPrimer, based on Primer 3, is a program for designing PCR primers for methylation mapping. It first takes a DNA sequence as its input and searches the sequence for potential CpG islands. Primers are then picked around the predicted CpG islands or around regions specified by users. MethPrimer can design primers for BSP and MSP. Results of primer selection are delivered through a web browser in text and in graphic view.
Pragmatics and word meaning (1998)

In this paper, we explore the interaction between lexical semantics and pragmatics. We argue that linguistic processing is informationally encapsulated and utilizes relatively simple ‘taxonomic’ lexical semantic knowledge. On this basis, defeasible lexical generalisations deliver defeasible parts of logical form. In contrast, pragmatic inference is open-ended and involves arbitrary real-world knowledge. Two axioms specify when pragmatic defaults override lexical ones. We demonstrate that modelling this interaction allows us to achieve a more refined interpretation of words in a discourse context than either the lexicon or pragmatics could do on their own.
Acute respiratory infections in the developing world (1987)

Issues in International Pediatric Infectious Diseases. Edited by Kenneth J. Bart, M.D. From the Office of Health, Bureau for Science and Technology, Agency for International Development, United States Department of State, Washington, DC.
Firearm Identification System Based on Ballistics Image Processing (2008)

Characteristic markings on the cartridge case and projectile of a fired bullet are created when it is fired. Over thirty different features within these marks can be distinguished, which in combination produce a "fingerprint" for a firearm. By analyzing features within such a set of firearm fingerprints, it will be possible to identify not only the type and model of a firearm, but also each every individual weapon as effectively as human fingerprint identification. A new analytic system based on fast Fourier transform (FFT) for identifying the projectile specimens by the line-scan imaging technique is proposed in this paper. Experimental results show that the proposed system can be used for firearm identification efficiently and precisely through digitizing and analyzing the fired projectiles specimens.
Single-cell printing to form three-dimensional lines of olfactory ensheathing cells (2008)

Biological laser printing (BioLP) is a unique tool capable of printing high resolution two- and three-dimensional patterns of living mammalian cells, with greater than 95% viability. These results have been extended to primary cultured olfactory ensheathing cells (OECs), harvested from adult Sprague-Dawley rats. OECs have been found to provide stimulating environments for neurite outgrowth in spinal cord injury models. BioLP is unique in that small load volumes ( approximately microLs) are required to achieve printing, enabling low numbers of OECs to be harvested, concentrated and printed. BioLP was used to form several 8 mm lines of OECs throughout a multilayer hydrogel scaffold. The line width was as low as 20 microm, with most lines comprising aligned single cells. Fluorescent confocal microscopy was used to determine the functionality of the printed OECs, to monitor interactions between printed OECs, and to determine the extent of cell migration throughout the 3D scaffold. High-resolution printing of low cell count, harvested OECs is an important advancement for in vitro study of cell interactions and functionality. In addition, these cell-printed scaffolds may provide an alternative for spinal cord repair studies, as the single-cell patterns formed here are on relevant size scales for neurite outgrowth.
Parabolic Radon transform, sampling and efficiency (2001)

Abstract A good choice of the sampling in the transform domain is essential for a successful application of the parabolic Radon transform. The parabolic Radon transform is computed for each temporal frequency and is essentially equivalent to the nonuniform Fourier transform. This leads to new and useful insights in the parabolic Radon transform. Using nonuniform Fourier theory, we derive a minimum sampling interval for the curvature parameter and a maximum curvature range for which stability is guaranteed for general (irregular) sampling. A significantly smaller sampling interval requires stabilization. If diagonal stabilization is used, no gain in resolution is obtained. In contrast to conventional implementations, the curvature sampling interval is proposed to be inversely proportional to the temporal frequency. This results in improved quality of the transform and yields significant savings in computation time.