gebhart/patrepeval huggingface dataset:
Perceptual audio coding using adaptive pre- and post-filters and lossless compression (2002)

This paper proposes a versatile perceptual audio coding method that achieves high compression ratios and is capable of low encoding/decoding delay. It accommodates a variety of source signals (including both music and speech) with different sampling rates. It is based on separating irrelevance and redundancy reductions into independent functional units. This contrasts traditional audio coding where both are integrated within the same subband decomposition. The separation allows for the independent optimization of the irrelevance and redundancy reduction units. For both reductions, we rely on adaptive filtering and predictive coding as much as possible to minimize the delay. A psycho-acoustically controlled adaptive linear filter is used for the irrelevance reduction, and the redundancy reduction is carried out by a predictive lossless coding scheme, which is termed weighted cascaded least mean squared (WCLMS) method. Experiments are carried out on a database of moderate size which contains mono-signals of different sampling rates and varying nature (music, speech, or mixed). They show that the proposed WCLMS lossless coder outperforms other competing lossless coders in terms of compression ratios and delay, as applied to the pre-filtered signal. Moreover, a subjective listening test of the combined pre-filter/lossless coder and a state-of-the-art perceptual audio coder (PAC) shows that the new method achieves a comparable compression ratio and audio quality with a lower delay.
Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor. (1982)

From the electric organ of Torpedo californica, we purified mRNA that, when translated in vitro, produces polypeptides immunoprecipitable by antibodies against purified acetylcholine receptor. A novel cloning system [Okayama, H. & Berg, P. (1982) Mol. Cell. Biol. 2, 161-170] was used to produce a cDNA library from this mRNA. This library contained clones with receptor sequences identified by differential hybridization and hybridization-selection. We describe a clone of 2,030 base pairs with sequences appropriate for the amino-terminal amino acids of the gamma subunit of acetylcholine receptor. This clone contains 82 bases 5' of the codon for the amino-terminal amino acid of the mature protein. A portion of this sequence codes for a methionine followed by a 16-amino acid polypeptide that is contiguous to the amino-terminal amino acid of the mature protein and that has the characteristics of a leader peptide. The cDNA insert hybridizes to a 2,100-base RNA present in electric organ but not in the brain of T. californica.
Comparative genomic hybridization in the detection of DNA copy number abnormalities in uveal melanoma. (1994)

Genomic instability appears to play an important role in the development, growth, invasiveness, and eventual metastasis of the neoplastic cell. We have used a powerful new technique, comparative genomic hybridization, to evaluate genetic alterations in 10 fresh frozen uveal melanomas. Comparative genomic hybridization utilizes dual fluorescence in situ hybridization to characterize chromosome deletions and duplications, allowing for simultaneous evaluation of the entire human genome. Several consistent chromosomal abnormalities were detected. This study confirmed previous findings obtained using standard cytogenetic techniques but demonstrated an increased incidence in abnormalities of chromosomes 3 and 8; there was loss of chromosome 3 and duplication of 8q. In addition, we identified, although less frequently, other recurrent abnormal regions including alterations on chromosomes 6p, 7q, 9p, and 13q.
Synthesis and Anti-HSV-1 Activity of 6 Substituted Pyrazolo[3,4-d]Pyridazin-7-one Nucleosides (1998)

Abstract a new series of 6-substituted N1- and N2 -β-D-ribofuranosyl-pyrazolo[3,4-d]pyridazin-7(6H)-one derivatives (8a-g, 9b-d and 9f-g) has been prepared in the aim to explore the structure-activity relationships and improve the antiviral activity of a series of N1-and N2 -β-D-ribofuranosyl-pyrazolo[4,3-d]pyrimidin-7(6H)-one derivatives previously reported by us. The studied compounds were preliminary tested for their in vitroa antiviral activity against HSV-1. Among them 8f and 9f were found 2 fold more active than those belonging to the parent series.
Determinants of DNA-Binding Specificity of ETS-Domain Transcription Factors (1996)

Several mechanisms are employed by members of transcription factor families to achieve sequence-specific DNA recognition. In this study, we have investigated how members of the ETS-domain transcription factor family achieve such specificity. We have used the ternary complex factor (TCF) subfamily as an example. ERK2 mitogen-activated protein kinase stimulates serum response factor-dependent and autonomous DNA binding by the TCFs Elk-1 and SAP-la. Phosphorylated Elk-1 and SAP-la exhibit specificities of DNA binding similar to those of their isolated ETS domains. The ETS domains of Elk-1 and SAP-la and SAP-2 exhibit related but distinct DNA-binding specificities. A single residue, D-69 (Elk-1) or V-68 (SAP-1), has been identified as the critical determinant for the differential binding specificities of Elk-1 and SAP-1a, and an additional residue, D-38 (Elk-1) or Q-37 (SAP-1), further modulates their DNA binding. Creation of mutations D38Q and D69V is sufficient to confer SAP-la DNA-binding specificity upon Elk-1 and thereby allow it to bind to a greater spectrum of sites. Molecular modelling indicates that these two residues (D-38 and D-69) are located away from the DNA-binding interface of Elk-1. Our data suggest a mechanism in which these residues modulate DNA binding by influencing the interaction of other residues with DNA.
Guanylyl Cyclase C–Induced Immunotherapeutic Responses Opposing Tumor Metastases Without Autoimmunity (2008)

Immunologic partitioning together with immunologic privilege highlight the potential of mucosa-restricted antigens, particularly GCC, as therapeutic targets for metastatic cancer.
Critical Role Played by Cyclin D3 in the MyoD-Mediated Arrest of Cell Cycle during Myoblast Differentiation (1999)

During the terminal differentiation of skeletal myoblasts, the activities of myogenic factors regulate not only tissue-specific gene expressions but also the exit from the cell cycle. The induction of cell cycle inhibitors such as p21 and pRb has been shown to play a prominent role in the growth arrest of differentiating myoblasts. Here we report that, at the onset of differentiation, activation by MyoD of the Rb, p21, and cyclin D3 genes occurs in the absence of new protein synthesis and with the requirement of the p300 transcriptional coactivator. In differentiated myocytes, cyclin D3 also becomes stabilized and is found nearly totally complexed with unphosphorylated pRb. The detection of complexes containing cyclin D3, cdk4, p21, and PCNA suggests that cdk4, along with PCNA, may get sequestered into high-order structures held together by pRb and cyclin D3. Cyclin D3 up-regulation and stabilization is inhibited by adenovirus E1A, and this correlates with the ability of E1A to promote pRb phosphorylation; conversely, the overexpression of cyclin D3 in differentiated myotubes counteracts the E1A-mediated reactivation of DNA synthesis. These results indicate that cyclin D3 critically contributes to the irreversible exit of differentiating myoblasts from the cell cycle.
Neural Architecture Search: A Survey (2018)

Deep Learning has enabled remarkable progress over the last years on a variety of tasks, such as image recognition, speech recognition, and machine translation. One crucial aspect for this progress are novel neural architectures. Currently employed architectures have mostly been developed manually by human experts, which is a time-consuming and error-prone process. Because of this, there is growing interest in automated neural architecture search methods. We provide an overview of existing work in this field of research and categorize them according to three dimensions: search space, search strategy, and performance estimation strategy.
A defective replicase gene induces resistance to cucumber mosaic virus in transgenic tobacco plants. (1992)

Nicotiana tabacum cv. Turkish Samsun NN plants were transformed with a modified and truncated replicase gene encoded by RNA-2 of cucumber mosaic virus strain Fny. The replicase gene had been modified by deleting a 94-base-pair region spanning nucleotides 1857-1950; the deletion also caused a shift in the open reading frame, resulting in a truncated translation product approximately 75% as large as the full-length protein. Upon transformation via Agrobacterium tumefaciens, transgenic plants were obtained that were resistant to virus disease when challenged with either cucumber mosaic virus virions or RNA at concentrations up to 500 micrograms/ml or 50 micrograms/ml, respectively, the highest concentrations tested. This resistance was absolute, as neither symptoms nor virus could be detected in uninoculated leaves, even after prolonged incubation (120 days after inoculation). These data suggest, therefore, that such a "replicase-mediated" resistance strategy may be applicable to other plant and animal viruses.
Performance Management for Cloud Services: Implementation and Evaluation of Schedulers for OpenStack (2013)

To achieve the best performance out of an IaaS cloud, the resource management layer must be able to distribute the workloads it is tasked with optimally on the underlying infrastructure. A utilization-based scheduler can take advantage of the fact that allocated resources and actual resource usage often differ to make better-informed decisions of where to place future requests. This thesis presents the design, implementation and evaluation of an initial placement controller that uses host utilization data as one of its inputs to help place virtual machines according to one of a number of supported management objectives. The implementation, which builds on top of the OpenStack cloud platform, deals with two different objectives, namely, balanced load and energy efficiency. The thesis also discusses additional objectives and how they can be supported. A testbed and demonstration platform consisting of the aforementioned controller, a synthetic load generator and a monitoring system are built and used during evaluation of the system. Results indicate that the scheduler performs equally well for both objectives using synthetically generated request patterns of both interactive and batch type workloads. A discussion of current limitations of the scheduler and ways to overcome those conclude the thesis. Among the things discussed are how the rate at which host utilization data is collected limits the performance of the scheduler and under which circumstances dynamic placement of virtual machines must be used to complement utilization-based scheduling to avoid the risk of overloading the cloud.
Spatiotemporal Dynamics of Sensory Responses in Layer 2/3 of Rat Barrel Cortex MeasuredIn Vivoby Voltage-Sensitive Dye Imaging Combined with Whole-Cell Voltage Recordings and Neuron Reconstructions (2003)

The spatiotemporal dynamics of the sensory response in layer 2/3 of primary somatosensory cortex evoked by a single brief whisker deflection was investigated by simultaneous voltage-sensitive dye (VSD) imaging and whole-cell (WC) voltage recordings in the anesthetized rat combined with reconstructions of dendritic and axonal arbors of L2/3 pyramids. Single and dual WC recordings from pyramidal cells indicated a strong correlation between the local VSD population response and the simultaneously measured subthreshold postsynaptic potential changes in both amplitude and time course. The earliest VSD response was detected 10-12 msec after whisker deflection centered above the barrel isomorphic to the stimulated principal whisker. It was restricted horizontally to the size of a single barrel-column coextensive with the dendritic arbor of barrel-column-related pyramids in L2/3. The horizontal spread of excitation remained confined to a single barrel-column with weak whisker deflection. With intermediate deflections, excitation spread into adjacent barrel-columns, propagating twofold more rapidly along the rows of the barrel field than across the arcs, consistent with the preferred axonal arborizations in L2/3 of reconstructed pyramidal neurons. Finally, larger whisker deflections evoked excitation spreading over the entire barrel field within approximately 50 msec before subsiding over the next approximately 250 msec. Thus the subthreshold cortical map representing a whisker deflection is dynamic on the millisecond time scale and strongly depends on stimulus strength. The sequential spatiotemporal activation of the excitatory neuronal network in L2/3 by a simple sensory stimulus can thus be accounted for primarily by the columnar restriction of L4 to L2/3 excitatory connections and the axonal field of barrel-related pyramids.
Extending the radiosity method to include specularly reflecting and translucent materials (1990)

An extension of the radiosity method is presented that rigorously accounts for the presence of a small number of specularly reflecting surfaces in an otherwise diffuse scene, and for the presence of a small number of specular or ideal diffuse transmitters. The relationship between the extended method and earlier radiosity and ray-tracing methods is outlined. It is shown that all three methods are based on the same general equation of radiative transfer. A simple superposition of the earlier radiosity and ray-tracing methods in order to account for specular behavior is shown to be physically inconsistent, as the methods are based on different assumptions. Specular behavior is correctly included in the present method. The extended radiosity method and example images are presented.
Active specific immunotherapy with tumor cells andCorynebacterium parvum. A phase I study (1979)

Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvum were given as weekly intracutaneous injections to fifteen patients with residual malignant disease. The toxicity was minimal and distinctly less than has been seen with tumor cell-BCG immunotherapy. A goal of 4 injections of 107 cells each was possible in only 4 patients because of limitations in methods of disaggregation and quantity of tumor available. The feasibility aspects are discussed and a case report of a prolonged regression is presented.
The landscape of kinase fusions in cancer (2014)

Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has uncovered numerous genes recurrently mutated, deleted or amplified, but gene fusions have not been characterized as extensively. Here we develop heuristics for reliably detecting gene fusion events in RNA-seq data and apply them to nearly 7,000 samples from The Cancer Genome Atlas. We thereby are able to discover several novel and recurrent fusions involving kinases. These findings have immediate clinical implications and expand the therapeutic options for cancer patients, as approved or exploratory drugs exist for many of these kinases.
Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer (1988)

We have used a retroviral vector that codes for the bacterial enzyme beta-galactosidase to study cell lineage in the rat cerebral cortex. This vector has been used to label progenitor cells in the cerebral cortices of rat embryos during the period of neurogenesis. When these embryos are allowed to develop to adulthood, the clones of cells derived from the marked progenitor cells can be identified histochemically. In this way, we can ask what are the lineage relationships between different neural cell types. From these studies, we conclude that there are two distinct types of progenitor cells in the developing cortex. One generates only grey matter astrocytes, whereas the second gives rise to neurones - both pyramidal and nonpyramidal - and to another class of cells that we have tentatively identified as glial cells of the white matter. We have also been able to address the question of how neurones are dispersed in the cortex during histogenesis. It had been previously hypothesized that clonally related neurones migrated radially to form columns in the mature cortex. However, we find that clones of neurones do not form radial columns; rather, they tend to occupy the same or neighbouring cortical laminae and to be spread over several hundreds of micrometers of cortex in the horizontal dimension. This spread occurs in both mediolateral and rostrocaudal directions.
Selective Glucocorticoid Receptor Ligands (2007)

Glucocorticoids are four-ring steroid compounds that regulate a wide range of physiological systems ranging from embryonic respiratory development, immune function and responses to acute or chronic stress. Glucocorticoids are taken up by many target cells where they bind and activate cytoplasmic glucocorticoid receptors (GRs), which then dimerize, translocate to the nucleus and function as ligand-dependent transcriptional regulators. Synthetic glucocorticoids such as dexamethasone and prednisolone have for decades been the cornerstone for the clinical treatment of inflammatory diseases, such as rheumatoid arthritis and asthma, yet prolonged use have undesirable side-effects such as persistent immune suppression, metabolic imbalance, obesity, diabetes, and osteoporosis. Detailed understanding of the cell signaling mechanisms of GR action has led to the development of novel selective glucocorticoid receptor ligands that appear to offer more efficient treatments for a number of diseases while eliciting fewer side-effects. Additionally, in cell-based and animal model systems a number of compounds such as the methane sulphonamides and a novel compound A-348441 have shown promise as GR antagonists. Other classes of ligands such as the benzopyranoquinolines and the arylpyrazoles have further been shown to selectively influence the transcriptional regulatory properties of GRs on different target gene in various cellular contexts. These selective GR modulators are believed to initiate transcriptional co-regulator recruitment that in turn promotes specific gene responses relevant to the more efficient and specific treatment of inflammatory conditions and metabolic diseases such as type-2 diabetes.
Micro Total Analysis Systems. Latest Advancements and Trends (2006)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMicro Total Analysis Systems. Latest Advancements and TrendsPetra S. Dittrich, Kaoru Tachikawa, and Andreas ManzView Author Information Institute for Analytical Sciences, Bunsen-Kirchhoff-Strasse 11, D-44139 Dortmund, Germany Cite this: Anal. Chem. 2006, 78, 12, 3887–3908Publication Date (Web):April 28, 2006Publication History Published online28 April 2006Published inissue 1 June 2006https://pubs.acs.org/doi/10.1021/ac0605602https://doi.org/10.1021/ac0605602review-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views8931Altmetric-Citations820LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Fluid dynamics,Genetics,Liquids,Microchips Get e-Alerts
Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory. (1979)

Both athymic nude mice and normal mice primed with a T-cell independent antigen, i.e. dinitrophenylated dextran (DNP-DE), at a sub-immunogenic dose, produced very poor anti-DNP responses to a later challenge with the same antigen. B-cell memory was expressed, however, as an enhanced IgM response after the challenge of the DNP-DE-primed mice with the T-cell dependent antigen (dinitrophenylated haemocyanin, DNP-KLH) in the presence of functional T-cells. Moreover, DNP-DE-primed spleen cells also revealed an enhanced IgM response after adoptive transfer into irradiated recipients and challenge with DNP-DE. The injections of DNP-DE-primed nude mouse serum into unprimed mice resulted in the reduction of anti-DNP response to the immunization with DNP-DE. These results indicate that (a) T-cell independent DNP-DE causes the differentiation of B cells not only into antibody-forming cells but also into memory cells, (b) these memory cells can be triggered in situ by the T-cell dependent DNP-KLH in the presence of helper T cells but not by T-cell independent antigen, and (c) some humoral factor(s) induced by DNP-DE-priming seems to interfere with the expression of B-cell memory only when challenged with T-cell independent DNP-DE.
Total Thoracic and partial to total Lumbar Sympathectomy, Splanchnicectomy and Celiac Ganglionectomy for Hypertension (1953)

Grimson, Keith S. M.D.; Orgain, Edward S. M.D.; Aderson, Banks M.D.; D'Angelo, George J. M.D. Author Information
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis (2002)

Hematopoietic stem cells (HSCs) maintain hematopoiesis by giving rise to all types of blood cells. Recent reports suggest that HSCs also possess the potential to generate nonhematopoietic tissues. To evaluate the underlying mechanisms in the commitment of HSCs into multitissue and multihematopoietic lineages, we performed oligonucleotide array analyses targeting for prospectively purified HSCs, multipotent progenitors (MPPs), common lymphoid progenitors (CLPs), and common myeloid progenitors (CMPs). Here we show that HSCs coexpress multiple nonhematopoietic genes as well as hematopoietic genes; MPPs coexpress myeloid and lymphoid genes; CMPs coexpress myeloerythroid, but not lymphoid genes, whereas CLPs coexpress T-, B-, and natural killer-lymphoid, but not myeloid, genes. Thus, the stepwise decrease in transcriptional accessibility for multilineage-affiliated genes may represent progressive restriction of developmental potentials in early hematopoiesis. These data support the hypothesis that stem cells possess a wide-open chromatin structure to maintain their multipotentiality, which is progressively quenched as they go down a particular pathway of differentiation.
Extrapulmonale Tuberkulose (2010)

Die pulmonale Tuberkulose ist eine selten Erkankungen mit abnehmender Inzidenz in Deutschland, noch seltener ist die extrapulmonale Tuberkulose mit 960 Fällen im Jahr 2007 in Deutschland. 47,8% der Fälle sind Lymphknoten-Manifestationen.
Notes on coelomycetes. II. Concerning the Fusicoccum anamorph of Botryosphaeria ribis (1987)

The Fusicoccum anamorph of Botryosphaeria ribis Grossenb.& Duggar is described and illustrated from collections made on several hosts in the southeastern United States and from pure culture.