gebhart/patrepeval huggingface dataset:
A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy (1994)

The proliferation of epithelial cells lining the small intestinal mucosa may be regulated by microenvironmental signals leading to differentiation of precursor cells in the small intestinal crypts. Proliferation of hematopoietic cells within the hematopoietic microenvironment is known to be regulated by a growing number of glycoprotein growth factors in a hierarchial fashion. We studied the effects of administration of the microenvironment-derived hematopoietic growth factor interleukin-11 (IL-11) on mice given combination radiation/chemotherapy. Treatment of such mice with IL-11 led to significantly increased survival and evidence of rapid recovery of the small intestinal mucosa, which is severely damaged by these cytoxic agents. This recovery was associated with an increase in the mitotic index of crypt cells and an increased frequency of staining of these cells with a monoclonal antibody to proliferating cell nuclear antigen, a member of the cyclin family of nuclear antigens.
Solid dispersions of carbamazepine with Gelucire 44/14 and 50/13 (2000)

La preparation de dispersions solides est une methode efficace pour augmenter la vitesse de dissolution de principes actifs peu solubles, et donc ameliorer leur biodisponibilite. La methode de la fusion du transporteur a ete utilisee pour preparer differents types de dispersions solides de carbamazepine et deux types de Gelucire (44/ 14 et 50/13). Les caracteristiques physiques des melanges binaires ont ete determinees par microscopie a platine chauffante, analyse enthalpique differentielle, diffractometrie de rayons X sur poudre et spectroscopie infrarouge de reflexion diffuse a transformee de Fourier. Enfin, des etudes de dissolution in vitro ont ete effectuees. Les cinetiques de dissolution ont montre que les deux Gelucire entrainaient une augmentation notable de la vitesse de dissolution de la carbamazepine, meme en presence d'une faible proportion de transporteur. L'amelioration de la dissolution du principe actif a ete attribuee a la reduction de la taille de ses particules eta l'augmentation de leur mouillabilite quand le polymere est dissous.
Network support for IP traceback (2001)

This paper describes a technique for tracing anonymous packet flooding attacks in the Internet back toward their source. This work is motivated by the increased frequency and sophistication of denial-of-service attacks and by the difficulty in tracing packets with incorrect, or "spoofed," source addresses. We describe a general purpose traceback mechanism based on probabilistic packet marking in the network. Our approach allows a victim to identify the network path(s) traversed by attack traffic without requiring interactive operational support from Internet service providers (ISPs). Moreover, this traceback can be performed "post mortem"-after an attack has completed. We present an implementation of this technology that is incrementally deployable, (mostly) backward compatible, and can be efficiently implemented using conventional technology.
ABCC1 polymorphism Arg723Gln (2168G > A) is associated with lung cancer susceptibility in a Chinese population (2011)

1. In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1-induced multidrug resistance. The aim of the present study was to further investigate the association of this polymorphism with lung cancer susceptibility and chemotherapy response in a Chinese population. 2. A total of 77 lung cancer patients (54 men, 23 women) and 71 cancer-free controls (49 men, 22 women) were enrolled in the study. Genomic DNA was extracted from peripheral blood and all samples were genotyped using polymerase chain reaction-restriction fragment length polymorphism. 3. Individuals carrying the 723Gln (A) allele have a 3.4-fold increased risk (adjusted odds ratio (OR) 3.42; 95% confidence interval (CI) 1.29-9.06; P = 0.013) of lung cancer compared with wild-type individuals. Further stratified analysis indicated that older individuals (> 50 years) carrying the 723Gln (A) allele have the highest susceptibility to lung cancer (adjusted OR 4.10; 95% CI 1.25-13.48; P = 0.020). However, no substantial association was found between the Arg723Gln (2168G > A) polymorphism and chemotherapy response in Chinese lung cancer patients. 4. In conclusion, the Arg723Gln (2168G > A) polymorphism of ABCC1 appears to be a potential susceptibility marker for lung cancer in the Chinese population, especially in older people.
Vinorelbine Tartrate and Paclitaxel Combinations: Enhanced Activity Against In Vivo P388 Murine Leukemia Cells (1995)

Results suggest that the overlapping toxic effects of vinorelbine tartrate and paclitaxel might not be a deterrent to their use in combination drug therapy. When used appropriately, rather than having enhanced toxic effects, otherwise toxic doses were better tolerated and survival improved over single-agent therapy.
Next Generation 5G Wireless Networks: A Comprehensive Survey (2016)

The vision of next generation 5G wireless communications lies in providing very high data rates (typically of Gbps order), extremely low latency, manifold increase in base station capacity, and significant improvement in users' perceived quality of service (QoS), compared to current 4G LTE networks. Ever increasing proliferation of smart devices, introduction of new emerging multimedia applications, together with an exponential rise in wireless data (multimedia) demand and usage is already creating a significant burden on existing cellular networks. 5G wireless systems, with improved data rates, capacity, latency, and QoS are expected to be the panacea of most of the current cellular networks' problems. In this survey, we make an exhaustive review of wireless evolution toward 5G networks. We first discuss the new architectural changes associated with the radio access network (RAN) design, including air interfaces, smart antennas, cloud and heterogeneous RAN. Subsequently, we make an in-depth survey of underlying novel mm-wave physical layer technologies, encompassing new channel model estimation, directional antenna design, beamforming algorithms, and massive MIMO technologies. Next, the details of MAC layer protocols and multiplexing schemes needed to efficiently support this new physical layer are discussed. We also look into the killer applications, considered as the major driving force behind 5G. In order to understand the improved user experience, we provide highlights of new QoS, QoE, and SON features associated with the 5G evolution. For alleviating the increased network energy consumption and operating expenditure, we make a detail review on energy awareness and cost efficiency. As understanding the current status of 5G implementation is important for its eventual commercialization, we also discuss relevant field trials, drive tests, and simulation experiments. Finally, we point out major existing research issues and identify possible future research directions.
Relationship of donor HLA antibody strength to the development of transfusion‐related acute lung injury (2010)

A correlation between the HLA antibody strength and development of TRALI was indicated. The antibody strength measured by ELISA could be used as the basis for the screening of HLA antibodies in place of the fluorescence beads method. This study provided clues to the establishment of a cutoff value for HLA antibody screening in an evidence-based manner for the prevention of TRALI.
Simple analytic spiral K-space algorithm (1999)

The exact, hardware-constrained design of a spiral k-space trajectory requires the solution of a differential equation, thereby making real-time prescription difficult on scanners with limited computational power. This study describes a closed-form approximate solution for interleaved Archimedian spiral trajectories that closely matches the exact design. Both slew rate-limited and amplitude-limited regimes are incorporated. Magn Reson Med 42:412-415, 1999.
A height-weight formula to estimate the surface area of man (1916)

Using the method previously described before this society, it has been possible, with the aid of Miss Sawyer and Mr. Stone, to measure the surface area of a total of 10 individuals. The “Linear Formula” previously described, when applied to these, gives an average error of 1.5 per cent. The chief limitation of the “Linear Formula” is that it involves the taking of 19 measurements. In the literature of the respiratory metabolism already published the only data given in regard to most of the subjects are the height and weight.On the basis of the actual measurement of the surface of 10 subjects of widely varying shape, formulas have been constructed on the plan of A = W1/a X H1/b X C, in which A is the surface area in square cm., W is the weight in kilograms and H the height in cm. and C a constant. Various formulas were tried, care being taken that 3/a + 1/b should always equal 2 in order that the formula might remain bi-dimensional. The formula A = W1/3 X H1/1 X C gave an average error of $$ 3.3 per cent. The formula A = W1/2 X H1/2 X C gave an average error of 2.2 per cent. It was evident that values for 1/a somewhere between 1/3 and 1/2 would give better results. By a rather lengthy process of calculation it was found that the average error could be reduced to 1.7 per cent. if the formula were made A = W1/2.35 X H1/1.38 X C. The calculation is not difficult if logarithms be used but a chart has been devised by means of which it is possible to estimate the surface area at a glance.
Synthesis and study of n-(2-mercapto-4,5-disubstituted phenyl)-n'-substituted-phenyl thioureas as possible antituberculosis agents. (1987)

A series of N-(2-mercapto-4,5-disubstituted-phenyl)-N'-substituted phenyl thioureas have been synthesized and screened in vitro against H37 Rv strain of Mycobacteriumtuberculosis. The antitubercular activity of these compounds vary from 50 mug/ml to 0.6 mug/ml.
Stable Mixed Hematopoietic Chimerism in DLA-Identical Littermate Dogs Given Sublethal Total Body Irradiation Before and Pharmacological Immunosuppression After Marrow Transplantation (1997)

Postgrafting cyclosporine (CSP) given for 35 days resulted in establishment of stable marrow grafts from DLA-identical canine littermates after otherwise suboptimal, but nevertheless, lethal conditioning with 450 cGy of total body irradiation (TBI). We now asked whether sustained allografts could be achieved after sublethal TBI or without TBI. Five groups of recipients were studied. Dogs in group 1 were given 200 cGy TBI and postgrafting CSP, 15 mg/kg twice daily by mouth on days -1 to 35 posttransplant. Dogs in group 2 were given 200 cGy TBI and methotrexate (MTX), 0.4 mg/kg intravenously (I.V.) on days 1, 3, 6, and 11 along with CSP. Dogs in group 3 were given 200 cGy TBI and CSP along with mycophenolate mofetil (MMF), 10 mg/kg twice daily subcutaneously (S.C.) on days 0 to 27 after transplant, a novel immunosuppressive combination. Dogs in group 4 were given 100 cGy TBI and MMF/CSP. Dogs in group 5 were not given TBI and they received MMF/CSP posttransplant. Allografts were assessed by (Ca)n dinucleotide repeat polymorphism studies in cells from peripheral blood, lymph nodes, and marrow. Dogs in group 1 had transient mixed donor-host hematopoietic chimerism for no more than 4 weeks. Three of six dogs in group 2 had transient mixed chimerism for 3 to 11 weeks, and three have remained stable mixed chimeras for up to 60 weeks now. Four of five dogs in group 3 have remained stable mixed chimeras for 54 to 57 weeks now, while one lost the allograft after 12 weeks. All dogs in groups 4 and 5 rejected their allografts after 2 to 12 weeks. In summary, the establishment of stable mixed hematopoietic chimerism following nonmyelosuppressive and nontoxic conditioning programs has remained a difficult goal. Here we present evidence in a large random-bred animal species that this goal may be achievable with pharmacological immunosuppression postgrafting, capable of inhibiting both host-versus-graft (HVG) and graft-versus-host (GVH) reactions in the setting of DLA-identical grafts.
Using GM (1,1) Optimized by MFO with Rolling Mechanism to Forecast the Electricity Consumption of Inner Mongolia (2016)

Accurate and reliable forecasting on annual electricity consumption will be valuable for social projectors and power grid operators. With the acceleration of electricity market reformation and the development of smart grid and the energy Internet, the modern electric power system is becoming increasingly complex in terms of structure and function. Therefore, electricity consumption forecasting has become a more difficult and challenging task. In this paper, a new hybrid electricity consumption forecasting method, namely grey model (1,1) (GM (1,1)), optimized by moth-flame optimization (MFO) algorithm with rolling mechanism (Rolling-MFO-GM (1,1)), was put forward. The parameters a and b of GM (1,1) were optimized by employing moth-flame optimization algorithm (MFO), which is the latest natured-inspired meta-heuristic algorithm proposed in 2015. Furthermore, the rolling mechanism was also introduced to improve the precision of prediction. The Inner Mongolia case discussion shows the superiority of proposed Rolling-MFO-GM (1,1) for annual electricity consumption prediction when compared with least square regression (LSR), GM (1,1), FOA (fruit fly optimization)-GM (1,1), MFO-GM (1,1), Rolling-LSR, Rolling-GM (1,1) and Rolling-FOA-GM (1,1). The grey forecasting model optimized by MFO with rolling mechanism can improve the forecasting performance of annual electricity consumption significantly.
Hiding in Plain Sight: Interleukin-11 Emerges as a Master Regulator of Fibrosis, Tissue Integrity, and Stromal Inflammation (2020)

Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease, kidney disease, drug-induced liver injury, and nonalcoholic steatohepatitis. IL-11 is a member of the IL-6 cytokine family and has several distinct properties that define its unique and nonredundant roles in disease. The IL-11 receptor is highly expressed on stromal, epithelial and polarized cells, where noncanonical IL-11 signaling drives the three pathologies common to all fibro-inflammatory diseases-myofibroblast activation, parenchymal cell dysfunction, and inflammation-while also inhibiting tissue regeneration. This cytokine has been little studied, and publications on IL-11 peaked in the early 1990s, when it was largely misunderstood. Here we describe recent advances in our understanding of IL-11 biology, outline how misconceptions as to its function came about, and highlight the large potential of therapies targeting IL-11 signaling for treating human disease.
Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease (2015)

Pediatric IBD is associated with reduced diversity in both fungal and bacterial gut microbiota. Specific Candida taxa were found to be increased in abundance in the IBD samples. These data emphasize the potential importance of fungal microbiota signatures as biomarkers of pediatric IBD, supporting their possible role in disease pathogenesis.
Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones. Rapid induction of a similar protein in both tissues. (1986)

Two-dimensional electrophoresis was used to detect a protein (ic) synthesized in rat corpus luteum cells in response to acute stimulation by human chorionic gonadotropin or dibutyryl cyclic AMP. This induced protein ic is isoelectric at pH 6.5 (isoelectric focusing) and has an apparent molecular weight of 28,000 (sodium dodecyl sulfate electrophoresis). The human chorionic gonadotropin or dibutyryl cyclic AMP dose response and time course of synthesis of the protein parallel those of progesterone synthesis in stimulated luteal cells. Additionally, cycloheximide, which inhibits the increase in progesterone formation caused by human chorionic gonadotropin or cAMP, also inhibits the synthesis of ic. Proteolytic polypeptide mapping suggests that ic has a very similar primary structure to another protein (pc), which has the same molecular weight as ic, differs from ic in pI, and is synthesized only in unstimulated cells. These polypeptide maps also demonstrate the close similarity of pc and ic to two proteins p and i, synthesized in control and in adrenocorticotropic hormone-stimulated rat adrenal cortex cells, respectively (Krueger, R. J. and Orme-Johnson, N. R. (1983) J. Biol. Chem. 258, 10159-10167). In both adrenal cortex and corpus luteum, binding of a tissue-specific polypeptide hormone acts via cAMP to cause increased steroidogenesis and induction of the synthesis of protein i (ic), with the same time course and hormone dose dependence. Also in both tissues, inhibition of protein synthesis at the level of translation (e.g. by cycloheximide addition) causes inhibition of i (ic) synthesis and of stimulated steroid production. This close correlation between the two different tissues in conditions which cause induction of the synthesis of these proteins suggests that the proteins may be common intermediaries in the control by polypeptide hormones of steroidogenesis in endocrine tissues.
Precision medicine in heritable cancer: when somatic tumour testing and germline mutations meet (2016)

Cancer is among the leading causes of death and disfigurement worldwide with an estimated global incidence of 14 million and ~8.2 million cancer-related deaths per annum. An estimated 5-10% of all cancers are hereditary, meaning a single gene mutation contributed to development of the cancer. In other words, inherited cancer has a worldwide incidence of ~1.4 million new cases per annum and a global prevalence of 300 million, and are often poorly recognised. The increase in genetic sequencing capability combined with the decrease in the cost of testing has altered both regulatory policy and clinical oncology practice Well-known examples of clinically important cancer susceptibility syndromes such as those caused by genetic mutations in highly penetrant genes such as <i>BRCA1/2</i> hereditary breast-ovarian cancer syndrome genes have provided the framework for the practice of clinical cancer genetics. There is no question that these tests have provided clinical benefit to the patient and her/his family. However, with the expanding role of next generation sequencing in tumour profiling as well as in germline testing, clinicians are now faced with significant new challenges and potentially unexpected opportunities. Issues such as determining how best to deal with gene variants of uncertain clinical significance and the issue of incidental findings of hereditary cancer risk may be encountered during tumour genomic testing will require a concerted effort and dialogue on the part of the broad genomic community.
Restriction fragment length polymorphism of the human c-fms gene. (1985)

By using blot hybridization with a v-fms probe, a polymorphism for EcoRI, HindIII, and BamHI restriction endonuclease sites associated with the human c-fms locus was observed in a random adult population. This restriction fragment length polymorphism can be explained on the basis of the existence of two alleles, a and b, and is due to a short (congruent to 500 base pairs) deletion characteristic of allele a. The distribution in the analyzed population (48 unrelated individuals) is 23% heterozygotes ab, 75% homozygotes bb, and 2% homozygotes aa. Though the inheritance of this polymorphism follows a Mendelian pattern, the children from couples ab X bb are of the following genotype: 74% ab and 26% bb. These deviations from the expected frequencies of 50% suggest a selective pressure in favor of heterozygotes.
4-Amino-7-chloroquinolines: Probing Ligand Efficiency Provides Botulinum Neurotoxin Serotype A Light Chain Inhibitors with Significant Antiprotozoal Activity (2013)

Structurally simplified analogues of dual antimalarial and botulinum neurotoxin serotype A light chain (BoNT/A LC) inhibitor bis-aminoquinoline (1) were prepared. New compounds were designed to improve ligand efficiency while maintaining or exceeding the inhibitory potency of 1. Three of the new compounds are more active than 1 against both indications. Metabolically, the new inhibitors are relatively stable and nontoxic. 12, 14, and 15 are more potent BoNT/A LC inhibitors than 1. Additionally, 15 has excellent in vitro antimalarial efficacy, with IC90 values ranging from 4.45 to 12.11 nM against five Plasmodium falciparum (P.f.) strains: W2, D6, C235, C2A, and C2B. The results indicate that the same level of inhibitory efficacy provided by 1 can be retained/exceeded with less structural complexity. 12, 14, and 15 provide new platforms for the development of more potent dual BoNT/A LC and P.f. inhibitors adhering to generally accepted chemical properties associated with the druggability of synthetic molecules.
Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus. (1989)

The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale. There was no significant differences between the mean percentage degrees of pruritus recorded with placebo, clemastine and ketotifen. By contrast, the mean percentage degree of pruritus recorded with prednisolone was significantly lower than those with the other three treatments. If these results are confirmed in patients with malaria, it might be more rational to administer a single prophylactic dose of prednisolone in those who experience very disturbing pruritus with chloroquine.
PNA forms an i-motif (2005)

A C-rich PNA hexanucleotide, p(C5T), has been shown to form an i-motif by nanoelectrospray ionization mass spectrometry coupled with H/D exchange, to have thermal stability comparable with its DNA analogue, but to exist over a much narrower pH range.
Muscle-Like Pneumatic Actuators for Below-Knee Prostheses, (2000)

This paper reports on the design of a biorobotic actuator intended for use in a powered, below-knee prosthesis. Design requirements for the artificial muscle and tendon are based on the properties of the natural limb. As biological properties often exhibit significant variability, data from a variety of vertebrate species are extracted from published reports in the biological literature and used to specify model parameters of both muscle and tendon. To achieve the required relationships between force, length, velocity, and activation, an artificial myo-tendinous actuator is proposed whose components include a flexible, pneumatic actuator, a hydraulic damper, and die compression springs. To verify performance, a series of tests were conducted that enveloped the conditions expected from a muscle-tendon unit used as an actuator for a below-knee prosthesis. The experimental results show the force-length-velocity properties of the artificial myo-tendinous actuator to be similar to its biological counterpart.