gebhart/patrepeval huggingface dataset:
Stretchable Interconnects for Elastic Electronic Surfaces (2005)

Elastic electronic surfaces will integrate stiff thin film devices onto compliant polymer substrates. These surfaces may be stretched once or many times, by up to tens of percent strain. One way to make such an elastic electronic surface is to distribute rigid subcircuit islands over the polymer surface, and then fabricate active devices on the islands. These islands need to be interconnected with stretchable metallization. We describe stretchable interconnects made of stripes of thin gold film patterned on elastomeric membranes. These membranes can be stretched by up to twice their initial length and maintain electrical conduction. We review the fabrication of these conductors, present their electrical and mechanical properties, and summarize our model for their extreme stretchability. Using such stretchable interconnects, we made the first elastic circuit, an inverter of thin film transistors. The circuit remains functional when stretched and relaxed by 12% strain.
New, Highly Active Metal Catalysts for the Hydrolysis of Borohydride (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew, Highly Active Metal Catalysts for the Hydrolysis of BorohydrideHerbert C. Brown and Charles A. BrownCite this: J. Am. Chem. Soc. 1962, 84, 8, 1493–1494Publication Date (Print):April 1, 1962Publication History Published online1 May 2002Published inissue 1 April 1962https://doi.org/10.1021/ja00867a034RIGHTS & PERMISSIONSArticle Views1237Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (258 KB) Get e-Alerts Get e-Alerts
A six-month trial of valacyclovir in the Epstein-Barr virus subsetof chronic fatigue syndrome: Improvement in left ventricularfunction (2002)

This study was designed to determine safety and efficacy of a 6-month trial of valacyclovir in single-virus Epstein-Barr virus (EBV) persistent infection. Phase I of this study used four specific criteria to define a subset of patients with chronic fatigue syndrome (CFS). In the second phase, myocardial dynamics were measured by MUGA rest/stress radionuclide ventriculographic (RVG) examinations pre- and posttreatment with valacyclovir. In phase I, a trial was performed in 19 consecutive CFS patients with the following diagnostic conditions: patients met criteria for diagnosis of CFS; they had had CFS for less than 1 year. They demonstrated repetitively abnormal oscillating T waves (ischemic or flat) at 24-h Holter monitoring; and they had elevated serum IgM antibody titers to EBV viral capsid antigen and/or total diffuse early antigen as measured by the enzyme-linked immunosorbent assay method. The treatment group comprised 10 CFS patients with no serum antibodies to human cytomegalovirus, but the control group (nine CFS patients) had, additionally, high titers of serum antibodies (IgG) to conformational structural antigens of human cytomegalovirus. Both the parallel treatment and control CFS groups received valacyclovir 1.0-1.5 gm q.6.h. for 6 months. This valacyclovir dose achieved serum acyclovir C(max) of > 7 microm and high antiviral activity versus EBV (IC(50) of 4.4-13.3 m). In phase II, six additional CFS patients met the same four criteria as the 19 CFS patients in phase I. They had, however, been ill for a mean of 55.8 months. Thus, 25 CFS patients comprise this study. The studies were carried out at a single outpatient practice in Birmingham, MI, U.S.A. Before initiating valacyclovir, and after 6 months of treatment, clinical and laboratory observations were made. The CFS Energy Index point score (Table I) was used to record each CFS patient's functional capacity at baseline and after 1, 3 and 6 months of valacyclovir. Energy Index point scores, as well as EBV and human cytomegalovirus serum antibody titers were assessed. In the second phase, left ventricular dynamics were repeated after 6 months of treatment with valacyclovir. We concluded that the 16 CFS patients (included in both phases of this study) with EBV-persistent infection (EBV single-virus subset) are improved after 6 months of continuous pharmacokinetic dosing with valacyclovir. Nine CFS patients with EBV/human cytomegalovirus co-infection did not benefit from 6 months of similar treatment. Valacyclovir is not an effective anti-human cytomegalovirus antiviral drug. Unimproved CFS patients with co-infections EBV and human cytomegalovirus may require combined treatment with valacyclovir and another drug more active against human cytomegalovirus. This preliminary trial, with a small number of patients, may be critical to an appropriately designed larger, double-blind, placebo-controlled trial.
Inkjet printing of conductive materials: a review (2012)

Purpose The purpose of this paper is to present an exhaustive review of research studies and activities in the inkjet printing of conductive materials. Design/methodology/approach This paper gives a detailed literature survey of research carried out in inkjet printing of conductive materials. Findings This article explains the inkjet printing process and the various types of conductive inks. It then examines the various factors that affect the quality of inkjet printed interconnects such as printing parameters, materials and substrate treatments. Methods of characterising both the inkjet printing process and the electrical properties of printed conductive materials are also presented. Finally relevant applications of this technology are described. Originality/value Inkjet printing is currently one of the cheapest direct write techniques for manufacturing. The use of this technique in electronic manufacturing, where interconnects and other conductive features are required is an area of increasing relevance to the fields of electronics manufacturing, packaging and assembly. This review paper would therefore be of great value and interest to this community.
The Isoelectric Points of Solid Oxides, Solid Hydroxides, and Aqueous Hydroxo Complex Systems (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Isoelectric Points of Solid Oxides, Solid Hydroxides, and Aqueous Hydroxo Complex SystemsGeorge A. ParksCite this: Chem. Rev. 1965, 65, 2, 177–198Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/cr60234a002https://doi.org/10.1021/cr60234a002research-articleACS PublicationsRequest reuse permissionsArticle Views10509Altmetric-Citations2900LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Role of tryptophan-388 of GLUT1 glucose transporter in glucose-transport activity and photoaffinity-labelling with forskolin (1993)

GLUT1 glucose-transporter cDNA was modified to substitute leucine for Trp-388 and transfected into Chinese hamster ovary cells using the expression vector termed pMTHneo. This tryptophan residue is conserved among most of the facilitative glucose-transporter isoforms and has been proposed to be the photolabelling site of forskolin, a competitive inhibitor of glucose transport. In addition, this residue is located on membrane-spanning helix 10 which is suggested to contain the dynamic segment of the transporter. The mutated glucose transporter was expressed and inserted into the plasma membrane in a fashion similar to the wild-type. Unexpectedly, this mutation did not abolish photolabelling with forskolin. However, the mutation induced a marked decrease in 2-deoxyglucose uptake with a 4-fold decrease in turnover number and a 1.25-fold increase in Km compared with the wild-type GLUT1. A similar decrease in zero-trans influx activity was also observed for 3-O-methylglucose. In contrast, no apparent decrease was observed in zero trans efflux activity for 3-O-methylglucose. The mutation decreased the turnover number of the glucose transporter in equilibrium exchange influx for 3-O-methylglucose by 33% without any change in Km. These results indicate that (1) Trp-388 is not the photolabelling site for forskolin, if we assume that the labelling occurs at a single site and (2) Trp-388 is more likely to be involved in interconversion between the inward-facing and outward-facing conformers of GLUT1 than binding of glucose, and thus, substitution of leucine for Trp-388 in this dynamic segment would decrease the rate of alternating conformation, which would preferentially affect the influx activity.
Ontology-based knowledge representation for bioinformatics (2000)

Much of biology works by applying prior knowledge ('what is known') to an unknown entity, rather than the application of a set of axioms that will elicit knowledge. In addition, the complex biological data stored in bioinformatics databases often require the addition of knowledge to specify and constrain the values held in that database. One way of capturing knowledge within bioinformatics applications and databases is the use of ontologies. An ontology is the concrete form of a conceptualisation of a community's knowledge of a domain. This paper aims to introduce the reader to the use of ontologies within bioinformatics. A description of the type of knowledge held in an ontology will be given.The paper will be illustrated throughout with examples taken from bioinformatics and molecular biology, and a survey of current biological ontologies will be presented. From this it will be seen that the use to which the ontology is put largely determines the content of the ontology. Finally, the paper will describe the process of building an ontology, introducing the reader to the techniques and methods currently in use and the open research questions in ontology development.
The development of Cowdria ruminantium in neutrophils. (1987)

The sequential development of C. ruminantium (Kwanyanga and Kümm isolates) was followed in caprine leukocyte cultures by light microscopy, direct immunofluorescent microscopy (DFA), indirect immunoflourescent microscopy (IFA) and transmission electron microscopy (TEM). During the febrile response, one to several small cocci, large ring forms or rods were observed in neutrophils in blood smears and cytopreparations of neutrophil fractions using Diff Quik stain, Giemsa stain, DFA and TEM. One to several C. ruminantium colonies were seen in up to 35% of neutrophils maintained in vitro for 18 h to 5 days. The organisms were located in neutrophil phagosomes by TEM and were enveloped by two trilamellar unit membranes. Initially, C. ruminantium was tightly enclosed within phagosomes. At 20 h of incubation, organisms were frequently observed undergoing binary fission within enlarged phagosomal vacuoles. At later time periods, neutrophils harboured fully formed colonies (morula) containing numerous organisms. An occasional C. ruminantium-infected macrophage (Kümm isolate), and an occasional infected eosinophil (Kümm and Kwanyanga isolate) were found.
A Brief Survey of Text Mining (2005)

The enormous amount of information stored in unstructured texts cannot simply be used for further processing by computers, which typically handle text as simple sequences of character strings. Therefore, specific (pre-)processing methods and algorithms are required in order to extract useful patterns. Text mining refers generally to the process of extracting interesting information and knowledge from unstructured text. In this article, we discuss text mining as a young and interdisciplinary field in the intersection of the related areas information retrieval, machine learning, statistics, computational linguistics and especially data mining. We describe the main analysis tasks preprocessing, classification, clustering, information extraction and visualization. In addition, we briefly discuss a number of successful applications of text mining.
Low insertion loss and low dispersion penalty InGaAsP quantum-well high-speed electroabsorption modulator for 40-Gb/s very-short-reach, long-reach, and long-haul applications (2002)

We present a metal-organic-chemical-vapor-deposition-grown low-optical-insertion-loss InGaAsP/InP multiple-quantum-well electroabsorption modulator (EAM), suitable for both nonreturn-to-zero (NRZ) and return-to-zero (RZ) applications. The EAM exhibits a dynamic (RF) extinction ratio of 11.5 dB at 1550 nm for 3 Vp-p drive under 40-Gb/s modulation. The optical insertion loss of the modulator in the on-state is -5.2 dB at 1550 nm. In addition, the EAM also exhibits a 3-dB small-signal response (S21) of greater than 38 GHz, allowing it to be used in both 40-Gb/s NRZ and 10-Gb/s RZ applications. The dispersion penalty at 40 Gb/s is measured to be 1.2 dB over /spl plusmn/40 ps/nm of chromatic dispersion. Finally, we demonstrate 40-Gb/s transmission performance over 85 km and 700 km.
A nested relational approach to processing SQL subqueries (2005)

One of the most powerful features of SQL is the use of nested queries. Most research work on the optimization of nested queries focuses on aggregate subqueries. However, the solutions proposed for non-aggregate subqueries are still limited, especially for queries having multiple subqueries and null values. In this paper, we show that existing approaches to queries containing non-aggregate subqueries proposed in the literature (including rewrites) are not adequate. We then propose a new efficient approach, the nested relational approach, based on the nested relational algebra. Our approach directly unnests non-aggregate subqueries using hash joins, and treats all subqueries in a uniform manner, being able to deal with nested queries of any type and any level. We report on experimental work that confirms that existing approaches have difficulties dealing with non-aggregate subqueries, and that our approach offers better performance. We also discuss some possibilities for algebraic optimization and the issue of integrating our approach in a relational database system.
Self-consistent mean field theory of the microphases of diblock copolymers (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-consistent mean field theory of the microphases of diblock copolymersJ. D. Vavasour and M. D. WhitmoreCite this: Macromolecules 1992, 25, 20, 5477–5486Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ma00046a055https://doi.org/10.1021/ma00046a055research-articleACS PublicationsRequest reuse permissionsArticle Views945Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemistry and Structure-Activity Relationships of Mecamylamine and Derivatives (1962)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTChemistry and Structure-Activity Relationships of Mecamylamine and DerivativesClement A. Stone, Mary L. Torchiana, Katherine L. Meckelnberg, John. Stavorski, Meyer. Sletzinger, Gustav A. Stein, William V. Ruyle, Donald F. Reinhold, Walter A. Gaines, Heinz. Arnold, and Karl. PfisterCite this: J. Med. Chem. 1962, 5, 4, 665–690Publication Date (Print):July 1, 1962Publication History Published online1 May 2002Published inissue 1 July 1962https://pubs.acs.org/doi/10.1021/jm01239a001https://doi.org/10.1021/jm01239a001research-articleACS PublicationsRequest reuse permissionsArticle Views316Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR (2006)

Using this simple approach, GAPDH was found to be the most suitable housekeeping gene for expression studies in reticulocytes while the commonly used B2M should be avoided.
Nuclear morphometry predicts disease-free interval for clinically localized adenocarcinoma of the prostate treated with definitive radiation therapy (1999)

Men treated for prostate cancer often have unexpected outcomes despite predictive models based on stage, grade and prostate-specific antigen (PSA). Previous results have indicated that nuclear morphometry can predict patient outcome in urologic malignancies. Application of this analytical method in prostate cancer treated with radiation therapy is limited. We have evaluated the predictive ability of nuclear morphometry in such patients. Histologic sections from 23 men with clinically localized adenocarcinoma of the prostate treated with radiation therapy were studied. Nuclear morphometric parameters were assessed using a previously described and validated system. Univariate and multivariate logistic regression analyses and a Cox proportional hazards model were used to assess the ability of nuclear morphometric parameters to predict recurrence and disease-free interval. Ten patients had no recurrence with median follow-up of 47. 5 months, while 13 had recurrence. Gleason grade was not predictive of treatment outcome. Pre-treatment PSA data, available for only 11 patients, were predictive of treatment outcome. Several nuclear morphometric parameters predicted recurrence, including upper quartile of suboptimal circle fit and upper quartile of feret-diameter ratio. A prognostic factor score incorporating these 2 parameters was derived, which predicted disease-free interval (p = 0.0014). Int. J. Cancer (Pred. Oncol.) 84:594-597, 1999.
Factorized Decision Trees for Active Learning in Recommender Systems (2013)

A key challenge in recommender systems is how to profile new users. A well-known solution for this problem is to use active learning techniques and ask the new user to rate a few items to reveal her preferences. The sequence of queries should not be static, i.e in each step the best query depends on the responses of the new user to the previous queries. Decision trees have been proposed to capture the dynamic aspect of this process. In this paper we improve decision trees in two ways. First, we propose the Most Popular Sampling (MPS) method to increase the speed of the tree construction. In each node, instead of checking all candidate items, only those which are popular among users associated with the node are examined. Second, we develop a new algorithm to build decision trees. It is called Factorized Decision Trees (FDT) and exploits matrix factorization to predict the ratings at nodes of the tree. The experimental results on the Netflix dataset show that both contributions are successful. The MPS increases the speed of the tree construction without harming the accuracy. And FDT improves the accuracy of rating predictions especially in the last queries.
Induction of CD4+ and CD8+ T-Cell Responses to the Human Stromal Antigen, Fibroblast Activation Protein: Implication for Cancer Immunotherapy (2005)

This study identifies FAP, a protease preferentially expressed in tumor-associated fibroblasts, as a candidate human stromal antigen to target in the setting of cancer immunotherapy, and shows that differential expression of stromal products is not a sufficient criteria to indicate its immunogenicity in a vaccination setting.