gebhart/patrepeval huggingface dataset:
Iloprost treatment for refractory Raynaud's phenomenon in two infants. (2009)

Raynaud's phenomenon (RP) is rare in young children. We describe two infants with severe RP, manifesting as fingertip necrosis, who were resistant to conventional vasodilators and were treated successfully with iloprost, a prostacyclin analogue. The application of iloprost is safe and should be considered in children with threatening ischemic digits.
Tensor Decompositions and Applications (2009)

This survey provides an overview of higher-order tensor decompositions, their applications, and available software. A tensor is a multidimensional or N-way array. Decompositions of higher-order tensors (i.e., N-way arrays with $N \geq 3$) have applications in psycho-metrics, chemometrics, signal processing, numerical linear algebra, computer vision, numerical analysis, data mining, neuroscience, graph analysis, and elsewhere. Two particular tensor decompositions can be considered to be higher-order extensions of the matrix singular value decomposition: CANDECOMP/PARAFAC (CP) decomposes a tensor as a sum of rank-one tensors, and the Tucker decomposition is a higher-order form of principal component analysis. There are many other tensor decompositions, including INDSCAL, PARAFAC2, CANDELINC, DEDICOM, and PARATUCK2 as well as nonnegative variants of all of the above. The N-way Toolbox, Tensor Toolbox, and Multilinear Engine are examples of software packages for working with tensors.
Exonucleolytic degradation of double-stranded RNA by an activity in Xenopus laevis germinal vesicles (2003)

We have identified, in extracts from Xenopus laevis germinal vesicles, a 5' exonuclease activity that cleaves double-stranded RNA (dsRNA). Features of the 5' ends of dsRNAs determine whether the strands are symmetrically or asymmetrically degraded. The activity hydrolyzes in the 5' to 3' direction, releasing 5'-mononucleotides processively, favoring strands with 5'-monophosphate termini; molecules with capped ends are resistant to digestion. Because of its ability to processively digest dsRNA to mononucleotides, we have named the exonuclease Chipper, which could cooperate or compete with Dicer (an endonuclease that produces molecules with a 5'-phosphate) in the processing of dsRNA.
Fiber-Optic Bend Sensor Based on Double Cladding Fiber (2015)

We develop and investigate fiber-optic bend sensor, which is formed by a section of double cladding SM630 fiber between standard SMF-28 fibers. The principle of operation of the sensor is based on coupling of the fiber core and cladding modes at the splices of fibers having different refractive index profiles. We use two sources with wavelengths 1328 and 1545 nm to interrogate the sensor. The dependences of transmission on curvature at these wavelengths are significantly different. We show that the proposed sensor is able to perform measurements of curvature with radii from meters to 26 cm with accuracy of about 3%.
Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities. (2000)

A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
Rescue of a foreign gene by Sendai virus. (1991)

A simple protocol for the rescue of a synthetic genome into a paramyxovirus has been developed. First, a synthetic Sendai virus-like RNA, containing the antisense coding region of the chloramphenicol acetyltransferase gene replacing the coding region of the Sendai virus genome, was transcribed from a cDNA. When introduced into cells that are infected with Sendai virus, this RNA construct was transcribed, replicated, and packaged into infectious virions. The addition of infected cell extract to the RNA prior to transfection markedly enhanced levels of chloramphenicol acetyltransferase expression and rescue. However, this enhancement is not due to encapsidation of the RNA into nucleocapsids as the RNA remains nuclease-sensitive. Uninfected cell extract also enhances expression and rescue efficiency, implying involvement of a cellular factor(s) with the synthetic viral-like RNA construct that allows for enhanced polymerase recognition. This system should allow for the dissection of the various cis-acting RNA signals within the paramyxovirus genome.
Evidence of localized surface plasmon enhanced magneto-optical effect in nanodisk array (2010)

Nanodisk array with sandwich structure of Au/[Co/Pt]n/Au was fabricated by electron beam lithography combined with argon ion milling. Excitation of localized surface plasmon resonance (LSPR) was demonstrated for various disk diameters. Magneto-optical (MO) properties were measured by a home-made micro-Faraday system at wavelengths of 633 and 690 nm. Faraday ellipticity at 690 nm showed non-monotonic dependence on disk diameter and reached maximum for disk diameter of 84 nm, which was associated with LSPR at 690 nm. The experimental results show direct evidence for LSPR enhancement effect on MO properties. The optical and MO properties were fitted by average field approximation.
System architectures using Fibre Channel (2002)

The author chronicles an apparent stagnation in the design and development of the channel interfaces which connect to primarily disk and tape mass storage peripherals, and explores the effect of this stagnation on the architectures of current computer systems. He notes that the traditional distributed system architectures and the concept of standard slots are increasingly becoming the roadblocks to the adoption of new computer systems architectures and new applications. He identifies the requirements for a new type of peripheral-channel interface to break this barrier, and shows how a standard called Fibre Channel which is presently under development, will fulfill those requirements. Examples are given of the new system configurations which Fibre Channel will facilitate and which will support new applications such as multimedia.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Skipping toward Personalized Molecular Medicine (2007)

“Personalized molecular medicine.” As with other catchy terms for big ideas, such as “reversing global warming” and “renewable energy,” the concept of personalized molecular medicine is certainly important, but the path to achieving it is far from clear. When such phrases are considered, definitions are important. Does personalized molecular medicine mean the tailoring of drugs for the individual patient, an approach that evokes images of Bones on Star Trek making instantaneous diagnoses with his Tricorder followed by loud pneumatic injections of customized drugs? Such a concept would place the realization of this technology in the same time frame as the . . .
11q23-24 loss is associated with chromosomal instability in endometrial cancer (2003)

A loss of the DNA copy number at chromosomal region 11q23-24 as detected by comparative genomic hybridization (CGH) is a marker of poor prognosis in patients with endometrial cancer. Malignant tumors display genetic instability, which is classified into two types: microsatellite instability (MIN) and chromosomal instability (CIN). In the present study, we examined whether there is a relation between loss of 11q23-24 and genetic instability in endometrial adenocarcinoma. Loss of 11q23-24 was detected in 4 of 70 endometrial cancers by fluorescence in situ hybridization (FISH), and DNA aneuploidy was detected by laser scanning cytometry (LSC) in 14 tumors. All tumors with 11q23-24 loss were aneuploid, and three of them were considered to have CIN. These findings suggest that 11q23-24 contains gene(s) necessary for normal chromosome replication and cell division.
Subject and citation indexing. Part I: The clustering structure of composite representations in the Cystic Fibrosis Document Collection (1991)

The presence of clustering structure in the cystic fibrosis (CF) Document Collection is evaluated as a function of the exhaustivity of five composite representations. The composite representations are constructed from two subject descriptions, based on Medical Subject Headings and subheadings, and two citation indexes, based on the complete set of references in and a comprehensive set of citations to each document. Experimental results reveal observable evidence for clustering structure at all exhaustivity levels of all composite representations but also show that the evidence for clustering structure diminishes as the exhaustivity of each representation is decreased. The representation composed of references and citations shows less evidence of clustering structure at the exhaustive level but more uniform evidence of clustering structure over a wide range of exhaustivity levels than composite representations that include subject descriptions. The structures imposed on the CF Document Collection by all composite representations satisfy the necessary condition for a meaningful clustering outcome. © 1991 John Wiley & Sons, Inc.
Structure/Function Of Oxygen-Regulated Isoforms In Cytochrome c Oxidase (1998)

Eukaryotic cytochrome c oxidases are complex oligomeric membrane proteins composed of subunit polypeptides encoded by both nuclear and mitochondrial genomes. While the mitochondrially encoded subunits are encoded by unique genes, some of the nuclear-encoded subunits are encoded by multigene families. The isoforms produced by these multigene families are tissue-specific and/or developmentally regulated in mammals and environmentally regulated in lower eukaryotes. Isoforms for one of the subunits, V, in the yeast Saccharomyces cerevisiae and one of the subunits, VII, in the slime mold Dictyostelium discoideum are regulated differentially by oxygen concentration. Extensive studies with the yeast subunit V isoforms have revealed that the genes for these proteins are switched on or off at very low oxygen concentrations (0.5-1 micromol l-1 O2) and that they affect the catalytic properties of holocytochrome c oxidase differentially. By altering an internal step in electron transfer between heme a and the binuclear reaction center (composed of heme a3 and CuB), the 'hypoxic' isoform, Vb, enhances the catalytic constant three- to fourfold relative to the 'aerobic' isoform, Va. Modeling studies suggest that this occurs by an interaction between transmembrane helix VII of subunit I and the transmembrane helix in subunit V. The inverse regulation of these two isoforms allows cells to assemble different types of holoenzyme isoenzymes in response to oxygen concentration. Oxygen also regulates the level of transcription of the genes for the other nuclear-coded subunits of yeast cytochrome c oxidase and affects the level of two of the mitochondrially encoded subunits (I and II) post-transcriptionally. Thus, the level of cytochrome c oxidase activity that is produced at different oxygen tensions in yeast is determined in part by the number of holoenzyme molecules that are assembled and in part by the oxygen-regulated isoforms of subunit V. The possibility that this type of control exists in other organisms is considered.
Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice (1999)

The p42 and p44 mitogen-activated protein kinases (MAPKs), also called Erk2 and Erk1, respectively, have been implicated in proliferation as well as in differentiation programs. The specific role of the p44 MAPK isoform in the whole animal was evaluated by generation of p44 MAPK-deficient mice by homologous recombination in embryonic stem cells. The p44 MAPK-/- mice were viable, fertile, and of normal size. Thus, p44 MAPK is apparently dispensable and p42 MAPK (Erk2) may compensate for its loss. However, in p44 MAPK-/- mice, thymocyte maturation beyond the CD4+CD8+ stage was reduced by half, with a similar diminution in the thymocyte subpopulation expressing high levels of T cell receptor (CD3high). In p44 MAPK-/- thymocytes, proliferation in response to activation with a monoclonal antibody to the T cell receptor in the presence of phorbol myristate acetate was severely reduced even though activation of p42 MAPK was more sustained in these cells. The p44 MAPK apparently has a specific role in thymocyte development.
Handbook of Solvents (2000)

Solvents are used in nearly all industries, from cosmetics to semiconductors, and from biotechnology research to iron and steel production. This book is a comprehensive and extensive textual analysis of the principles of solvent selection and use. It is a balanced presentation of solvent performance, processing characteristics, and environment and health issues. The book is intended to help formulators select ideal solvents, safety coordinators to protect workers, legislators and inspectors to define and implement technically correct public safeguards on solvent use, handling, and disposal. The contributors are members of prestigious universities and industries from around the world. Altogether, they have written 47 books and hundreds of paper on the subject of solvents. Here they give a synthesis of their experiences and opinions on how to best change the global use of solvents in order to both benefit from the technology, and limit health, safety, and environmental risks.
Transformation of Symmetrization Order to Nuclear-Spin Magnetization by Chemical Reaction and Nuclear Magnetic Resonance (1986)

A method of obtaining very large nuclear-spin polarizations is proposed and illustrated by density-operator calculations. The prediction is that chemical reaction and rf irradiation can convert the scalar parahydrogen state into polarization of order unity on the nuclear spins of the products of molecular-hydrogen addition reactions. A means of extending the resultant sensitivity enhancement to other spins is proposed in which the transfer of order occurs through population differences not associated with magnetization.
Properties In Vivo of Chelate-Tagged Proteins and Polypeptides (1982)

Attaching chelating groups to biological molecules and adding radioactive metal ions into the chelating groups provide short-lived radiotracers for diagnostic studies. Choosing the attachment site is restricted when a small polypeptide such as bleomycin (mol wt ≈ 1400) is to be conjugated to a derivative of 1-benzyl-EDTA (mol wt ≈ 400), but the terminal amine region of bleomycin may be modified without destroying its in vivo cancer-localizing properties. A larger number of acceptable labeling sites is expected for a macromolecule such as albumin (mol wt ≈ 68,000). However, the in vivo properties of chelate-tagged albumin depend exquisitely on the chemical-labeling procedure that is used. For example, diazonium coupling yields chelate-protein conjugates which, upon being added to the circulation, are broken down quickly in the liver. On the other hand, alkylating the albumin sulfhydryl group with a relatively selective bromoacetamide reagent yields a product which resembles the native protein in vivo.
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides (1992)

Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data. Moreover, artemisinin (1) and 4 had equivalent ED50's against P. berghei in vivo in the multiple-dose Thompson test; neither showed any evidence of acute toxicity at total doses of more than 12 g/kg. Dispiro-1,2,4,5-tetraoxane 4 had IC50's comparable to those of 1 against Plasmodium falciparum clones in vitro. These results confirm the potential of dispiro-1,2,4,5-tetraoxanes as a new class of inexpensive peroxide antimalarial drugs.
Bacteriorhodopsin encapsulated in transparent sol-gel glass: a new biomaterial (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBacteriorhodopsin encapsulated in transparent sol-gel glass: a new biomaterialShuguang Wu, Lisa M. Ellerby, J. S. Cohan, Bruce Dunn, M. A. El-Sayed, J. Selverstone Valentine, and Jeffrey I. ZinkCite this: Chem. Mater. 1993, 5, 1, 115–120Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/cm00025a022https://doi.org/10.1021/cm00025a022research-articleACS PublicationsRequest reuse permissionsArticle Views403Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. (1995)

VPF/VEGF is a multifunctional cytokine that contributes to angiogenesis by both direct and indirect mechanisms. On the one hand, VPF/VEGF stimulates the ECs lining nearby microvessels to proliferate, to migrate, and to alter their pattern of gene expression. On the other hand, VPF/VEGF renders these same microvascular ECs hyperpermeable so that they spill plasma proteins into the extravascular space, leading to the clotting of extravasated fibrinogen with deposition of a fibrin gel. Extravascular fibrin serves as a provisional matrix that favors and supports the ingrowth of new blood vessels and other mesenchymal cells that generate mature, vascularized stroma. These same principles apply in tumors, in several examples of non-neoplastic pathology, and in physiological processes that involve angiogenesis and new stroma generation. In all of these examples, microvascular hyperpermeability and the introduction of a provisional, plasma-derived matrix precede and accompany the onset of EC division and new blood vessel formation. It would seem, therefore, that tumors have "borrowed" fundamental mechanisms that developed in multicellular organisms for purposes of tissue defense, renewal, and repair. VPF/VEGF, therefore has taught us something new about angiogenesis; namely, that vascular hyperpermeability and consequent plasma protein extravasation are important, perhaps essential, elements in its generation. However, this finding raises a paradox. While VPF/VEGF induces vascular hyperpermeability, other potent angiogenic factors apparently do not, at least in subtoxic concentrations that are more than sufficient to induce angiogenesis. Nonetheless, wherever angiogenesis has been studied, the newly generated vessels have been found to be hyperpermeable. How, therefore, do angiogenic factors other than VPF/VEGF lead to the formation of new and leaky blood vessels? We do not as yet have a complete answer to this question. One possibility is that at least some angiogenic factors mediate their effect by inducing or stimulating the expression of VPF/VEGF. In fact, there is already one clear example of this. TGF-alpha is a potent angiogenic factor but does not itself increase microvascular permeability. However, TGF-alpha strikingly upregulates VPF/VEGF expression in cultured keratinocytes and is thought to be responsible, at least in part, for the overexpression of VPF/VEGF in psoriasis. Moreover, overexpression of TGF-alpha, along with that of the EGF receptor with which it interacts, is characteristic of many malignant tumors, raising the possibility that TGF-alpha acts to stimulate VPF/VEGF expression in other types of epithelial cells and in this manner induces angiogenesis.(ABSTRACT TRUNCATED AT 400 WORDS)
Mucous Cytokine Levels in Chronic Rhinosinusitis–Associated Olfactory Loss (2016)

In this study, inflammatory cytokines were found in mucus collected from the olfactory cleft. Levels of IL-5, in addition to other cytokines, were associated with objective olfactory function. Further inquiry is needed to establish the source of mucous cytokines and establish whether they play a causal role in olfactory loss.
Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis (2008)

In an increasing number of cancers, tumor populations called cancer stem cells (CSCs), or tumor-initiating cells, have been defined in functional assays of self-renewal and tumor initiation. Moreover, recent work in several different cancers has suggested the CSC population as a source of chemotherapy and radiation-therapy resistance within tumors. Work in glioblastoma and breast cancers supports the idea that CSCs may possess innate resistance mechanisms against radiation- and chemotherapy-induced cancer cell death, allowing them to survive and initiate tumor recurrence. Several resistance mechanisms have been proposed, including amplified checkpoint activation and DNA damage repair as well as increased Wnt/beta-catenin and Notch signaling. Novel targeted therapies against the DNA damage checkpoint or stem-cell maintenance pathways may sensitize CSCs to radiation or other therapies. Another important category of cancer therapies are antiangiogenic and vascular targeting agents, which are also becoming integrated in the treatment paradigm of an increasing number of cancers. Recent results from our laboratory and others support a role for CSCs in the angiogenic drive as well as the mechanism of antiangiogenic agents. Identifying and targeting the molecular mechanisms responsible for CSC therapeutic resistance may improve the efficacy of current cancer therapies.
Allelic Analysis of the Maize amylose-extender Locus Suggests That Independent Genes Encode Starch-Branching Enzymes IIa and IIb (1996)

Starch branching enzymes (SBE) catalyze the formation of [alpha]-1,6-glucan linkages in the biosynthesis of starch. Three distinct SBE isoforms have been identified in maize (Zea mays L.) endosperm, SBEI, IIa, and IIb. Independent genes have been identified that encode maize SBEI and IIb; however, it has remained controversial as to whether SBEIIa and IIb result from posttranscriptional processes acting on the product of a single gene or whether they are encoded by separate genes. To investigate this question, we analyzed 16 isogenic lines carrying independent alleles of the maize amylose-extender (ae) locus, the structural gene for SBEIIb. We show that 22 d after pollination ae-B1 endosperm expressed little Sbe2b (ae)-hybridizing transcript, and as expected, ae-B1 endosperm also lacked detectable SBEIIb enzymatic activity. Significantly, we show that ae-B1 endosperm contained SBEIIa enzymatic activity, strongly supporting the hypothesis that endosperm SBEIIa and IIb are encoded by separate genes. Furthermore, we show that in addition to encoding the predominant Sbe2b-hybridizing message expressed in endosperm, the ae gene also encodes the major Sbe2b-like transcript expressed in developing embryos and tassels.