gebhart/patrepeval huggingface dataset:
A New Depression Scale Designed to be Sensitive to Change (1979)

The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described. Ratings of 54 English and 52 Swedish patients on a 65 item comprehensive psychopathology scale were used to identify the 17 most commonly occurring symptoms in primary depressive illness in the combined sample. Ratings on these 17 items for 64 patients participating in studies of four different antidepressant drugs were used to create a depression scale consisting of the 10 items which showed the largest changes with treatment and the highest correlation to overall change. The inner-rater reliability of the new depression scale was high. Scores on the scale correlated significantly with scores on a standard rating scale for depression, the Hamilton Rating Scale (HRS), indicating its validity as a general severity estimate. Its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change. The practical and ethical implications in terms of smaller sample sizes in clinical trials are discussed.
Contributions of tissue culture studies to an understanding of the biology of cancer: a review. (1957)

In this review recent contributions of tissue culture studies are related to some of the current thinking on cancer biology. Special attention is directed to the view of the natural history of cancer as a kind of developmental process that involves both tumor and host. The topics of carcinogenesis, carcinoma in situ , local invasion, metastasis, diagnosis, and chemotherapy are considered.

Tissue culture technics appear to have particular promise in elucidating some of the primary mechanisms in the developmental biology of cancer, especially in the realm of interaction between cancer and normal cells.

Two points of speculation on the mechanisms of invasion are offered. These appear to be plausible on the basis of preliminary experiments and are being examined with further experimentation. One point suggests that a mechanism acting to limit the spread of cancer comes into operation for tumors that produce extensive dissolution of the surrounding ground substance. According to this scheme such lysis is accompanied by progressive coalescing and matting of connective tissue fibers, tending to confine the expansive growth of the tumor.

The other point suggests that aggregates of cancer cells function as supracellular units and that the mechanisms controlling the size and duplication of such units are related to the capacity of tumors to invade normal tissues.
From dirt to shovels (2008)

An ad hoc data source is any semistructured data source for which useful data analysis and transformation tools are not readily available. Such data must be queried, transformed and displayed by systems administrators, computational biologists, financial analysts and hosts of others on a regular basis. In this paper, we demonstrate that it is possible to generate a suite of useful data processing tools, including a semi-structured query engine, several format converters, a statistical analyzer and data visualization routines directly from the ad hoc data itself, without any human intervention. The key technical contribution of the work is a multi-phase algorithm that automatically infers the structure of an ad hoc data source and produces a format specification in the PADS data description language. Programmers wishing to implement custom data analysis tools can use such descriptions to generate printing and parsing libraries for the data. Alternatively, our software infrastructure will push these descriptions through the PADS compiler, creating format-dependent modules that, when linked with format-independent algorithms for analysis and transformation, result infully functional tools. We evaluate the performance of our inference algorithm, showing it scales linearlyin the size of the training data - completing in seconds, as opposed to the hours or days it takes to write a description by hand. We also evaluate the correctness of the algorithm, demonstrating that generating accurate descriptions often requires less than 5% of theavailable data.
Spectrum-sliced fiber amplifier light source for multichannel WDM applications (1993)

A potentially inexpensive light source for multichannel WDM applications is proposed. The high-power amplified spontaneous emission (ASE) from an erbium-doped fiber amplifier (EDFA), which is already in the single-mode fiber, can be efficiently divided into many channels by using an integrated optic wavelength-division-multiplexing (WDM) demultiplexer. This spectrum-sliced ASE can be used as light sources for WDM systems in place of several wavelength-selected DFB lasers. To demonstrate the principle, the 40-nm-wide ASE spectrum of an EDFA was sliced using a narrow optical filter (3-dB bandwidth: 1.3 nm), and the resulting source was used for the transmission of up to 1.7 Gb/s of data. The problem of spontaneous-spontaneous beat noise in these sources is dealt with. It is estimated that the total capacity would be about 40 Gb/s, realistically, since the channel spacing should be at least three times the optical bandwidth of each channel to avoid crosstalk.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dupuytren's disease: diagnosis and treatment. (2007)

Dupuytren's disease is a progressive condition that causes the fibrous tissue of the palmar fascia to shorten and thicken. The disease is common in men older than 40 years; in persons of Northern European descent; and in persons who smoke, use alcohol, or have diabetes. Patients present with a small, pitted nodule (or multiple nodules) on the palm, which slowly progresses to contracture of the fingers. The disease initially can be managed with observation and nonsurgical therapy. It will regress without treatment in approximately 10 percent of patients. Steroid injection into the nodule has been shown to reduce the need for surgery. Surgical referral should be made when metacarpophalangeal joint contracture reaches 30 degrees or when proximal interphalangeal joint contracture occurs at any degree. Timing of surgical intervention varies, but surgery is usually performed when the metacarpophalangeal joint contracture exceeds 40 degrees or when the proximal interphalangeal joint contracture exceeds 20 degrees. In-office percutaneous needle aponeurotomy is an alternative to surgery.
Infection of a chimpanzee with hepatitis C virus grown in cell culture. (1998)

Culture supernatant harvested from Daudi cells, a lymphoplastoid cell line, after 58 days of infection with the H77 strain of hepatitis C virus (HCV), was inoculated into a chimpanzee. HCV RNA, as detected by RT-PCR, first appeared in the serum and liver 5 and 6 weeks, respectively, after inoculation. Peripheral blood mononuclear cells (PBMC) collected on week 7 were also positive for HCV RNA. The major sequences of hypervariable region 1 (HVR1) of the viral genome recovered from the inoculated chimpanzee were the ones which were the majority in the original H77 inoculum and not those which were in the majority in the culture supernatant. Only the sequence recovered from PBMC was the same as the major one found in the cell culture.
Inhibition of a Golgi Complex Lysophospholipid Acyltransferase Induces Membrane Tubule Formation and Retrograde Trafficking (2003)

Recent studies have suggested that formation of Golgi membrane tubules involves the generation of membrane-associated lysophospholipids by a cytoplasmic Ca2+-independent phospholipase A2 (PLA2). Herein, we provide additional support for this idea by showing that inhibition of lysophospholipid reacylation by a novel Golgi-associated lysophosphatidylcholine acyltransferase (LPAT) induces the rapid tubulation of Golgi membranes, leading in their retrograde movement to the endoplasmic reticulum. Inhibition of the Golgi LPAT was achieved by 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976), a previously characterized antagonist of acyl-CoA cholesterol acyltransferase. The effect of CI-976 was similar to that of brefeldin A, except that the coatomer subunit beta-COP remained on Golgi-derived membrane tubules. CI-976 also enhanced the cytosol-dependent formation of tubules from Golgi complexes in vitro and increased the levels of lysophosphatidylcholine in Golgi membranes. Moreover, preincubation of cells with PLA2 antagonists inhibited the ability of CI-976 to induce tubules. These results suggest that Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a PLA2 or by inhibition of an LPAT. These two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation.
Protamine inhibits coronary collateral development in a canine model of repetitive coronary occlusion (1995)

Protamine has been demonstrated to inhibit angiogenesis in vitro and in vivo; however, its effect on coronary collateral development has not been examined. The present investigation tested the hypothesis that subcutaneously administered protamine inhibits canine coronary collateral development in response to chronic myocardial ischemia. Dogs underwent daily, repetitive, 2-min, left anterior descending coronary artery (LAD) occlusions for 22 consecutive days. Regional myocardial blood flow (radioactive microspheres), LAD segment shortening, and coronary flow debt repayment were measured in saline-treated (n = 7) and protamine-treated (n = 6) dogs on days 1, 8, 15, and 22. Coronary collateral development in saline-treated dogs was demonstrated by time-dependent significant (P < 0.05) increases in collateral blood flow to ischemic myocardium [day 1 0.10 +/- 0.01 vs. day 22 0.88 +/- 0.05 (SE) ml.min-1.g-1], progressive normalization of myocardial contractile function during LAD occlusion, and successive reduction in flow debt repayment. In contrast, protamine treatment significantly attenuated, increases in collateral perfusion (day 1 0.13 +/- 0.02 vs. day 22 0.36 +/- 0.03 ml.min-1.g-1). Regional contractile dysfunction and postocclusive reactive hyperemic responses were sustained over time in protamine-treated compared with saline-treated dogs. The results demonstrate that protamine inhibits coronary collateral development in response to chronic myocardial ischemia.
Chirped pulse enhancement of multiphoton absorption in molecular iodine (1998)

Chirp effects on three photon absorption yields in I2 vapor are investigated using femtosecond pulses with center wavelengths in the region 550–600 nm. Enhancements of as much as a factor of 3 are observed for chirped pulses with respect to transform-limited, zero chirp pulses. Theoretical considerations and model calculations suggest that wave packet dynamics play an important role.
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis (2010)

Our findings suggest that dietary saturated fat plays a protective role against MCDD-induced steatohepatitis, whereas TLR-2 deficiency exacerbated NASH. The mechanism underlying the response to dietary fat and TLR-2 likely involves altered signalling via the TLR-4 pathway.
New ranking algorithms for parsing and tagging (2001)

This paper introduces new learning algorithms for natural language processing based on the perceptron algorithm. We show how the algorithms can be efficiently applied to exponential sized representations of parse trees, such as the "all subtrees" (DOP) representation described by (Bod 1998), or a representation tracking all sub-fragments of a tagged sentence. We give experimental results showing significant improvements on two tasks: parsing Wall Street Journal text, and named-entity extraction from web data.
Two-dimensional conductometric detection in ion chromatography: sequential suppressed and single column detection (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional conductometric detection in ion chromatography: sequential suppressed and single column detectionIngemar. Berglund, Purnendu K. Dasgupta, Jorge L. Lopez, and Osamu. NaraCite this: Anal. Chem. 1993, 65, 9, 1192–1198Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/ac00057a015https://doi.org/10.1021/ac00057a015research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Influence of carbon nanotube length on toxicity to zebrafish embryos (2012)

There is currently a large difference of opinion in nanotoxicology studies of nanomaterials. There is concern about why some studies have indicated that there is strong toxicity, while others have not. In this study, the length of carbon nanotubes greatly affected their toxicity in zebrafish embryos. Multiwalled carbon nanotubes (MWCNTs) were sonicated in a nitric acid solution for 24 hours and 48 hours. The modified MWCNTs were tested in early developing zebrafish embryo. MWCNTs prepared with the longer sonication time resulted in severe developmental toxicity; however, the shorter sonication time did not induce any obvious toxicity in the tested developing zebrafish embryos. The cellular and molecular changes of the affected zebrafish embryos were studied and the observed phenotypes scored. This study suggests that length plays an important role in the in vivo toxicity of functionalized CNTs. This study will help in furthering the understanding on current differences in toxicity studies of nanomaterials.
An Introduction to Helium Ion Microscopy and its Nanotechnology Applications (2006)

A new imaging technology based on a scanning helium ion beam has been realized. This technology has several advantages over the traditional SEM. Due to the very high source brightness, and the shorter wavelength of the helium ions, it is possible to focus the ion beam to a smaller probe size relative to a SEM. Also, as the ion beam interacts with the sample, it does not suffer from a large excitation volume, and hence provides sharp images on a wide range of materials. Compared to a SEM, the secondary electron yield is quite high - allowing for imaging with currents as low as 1 femtoamp. The detectors provide information-rich images which offer topographic, material, crystallographic, and electrical properties of the sample. In contrast to other ion beams, there is no discernable sample damage due to the relatively light mass of the helium ion.
Transfer of human lymph chylomicron constituents to other lipoprotein density fractions during in vitro lipolysis (1982)

To ascertain whether chylomicron constituents would be transferred to low density lipoprotein (LDL, d 1.019-1.063 g/ml) and high density lipoprotein (HDL, d 1.063-1.21 g/ml) density fractions during lipolysis in the absence of other lipoproteins, the in vitro effect of bovine milk lipoprotein lipase on human thoracic duct lymph chylomicrons in the presence of albumin was examined. In incubations without lipase, over 90% of chylomicron constituents remained in the 1.006 g/ml supernate, and large particles ranging in diameter mainly from 750-6000 A were observed by electron microscopy. After the addition of lipase, lipolysis ranged from 69.0-94.6% and numerous collapsed particles with redundant surface were seen, as well as smaller particles within the LDL and HDL density region. With lipolysis, the majority of chylomicron cholesterol and phospholipid mass was transferred to LDL and HDL, while chylomicron apolipoprotein (apo) A-I, A-II, and C-II mass was transferred mainly to HDL. Utilizing either radioiodinated apoA-I and apoA-II reassociated with chylomicrons or radiolabeled chylomicrons, a similar redistribution of apoA-I and apoA-II radioactivity was noted with lipolysis. In contrast, chylomicron apoB (mainly B-48) radioactivity was transferred predominantly to LDL with lipolysis. These data are consistent with the concept that during lymph chylomicron triglyceride hydrolysis, chylomicron apolipoproteins, cholesterol, and phospholipid can be transferred to the LDL and HDL density regions in the absence of acceptor particles.
Chemistry of oxaziridines. 18. Synthesis and enantioselective oxidations of the [(8,8-dihalocamphoryl)sulfonyl]oxaziridines (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of oxaziridines. 18. Synthesis and enantioselective oxidations of the [(8,8-dihalocamphoryl)sulfonyl]oxaziridinesFranklin A. Davis, Michael C. Weismiller, Christopher K. Murphy, R. Thimma Reddy, and Band Chi ChenCite this: J. Org. Chem. 1992, 57, 26, 7274–7285Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://doi.org/10.1021/jo00052a050RIGHTS & PERMISSIONSArticle Views1193Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
New Approach to the Synthesis of Deoxyribonucleoside Phosphoramidite Derivatives (1986)

Abstract The deoxyribonucleoside phosphoramidites with various protecting groups at phosphorus have been prepared rapidly in good yields in one-pot reaction from bis(diisopropylamino)chlorophosphine as a new phosphitylating agent without isolation of bis(diisopropylamino)alkoxyphosphines.
Lens transglutaminase and cataract formation. (1981)

A protein polymer characteristically present in human cataract was shown to contain significant amounts of gamma-glutamyl-epsilon-lysine isopeptides. It is proposed that these crosslinks are produced by the action of transglutaminase (R-glutaminyl-peptide:amine-gamma-glutamyl-yltransferase, EC 2.3.2.13), which is all the more plausible because lens contains the enzyme and endogenous protein substrates for it. The enzyme is similar to that obtained from liver and is Ca2+ dependent. Highest apparent activity is found in lens cortex. When cortex homogenate from the rabbit was incubated in the presence of Ca2+ with either [14C]putrescine or with dansylcadaverine, a a selective incorporation of the radioactive or fluorescent amine into the heavier subunits (Mr approximately 26,000 and 30,000) of beta-crystallins could be demonstrated. Possible modes of regulating the crosslinking activity of this enzyme in lens are discussed.
Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies (2018)

Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. Here, we evaluate a potent broadly protective influenza virus vaccine candidate that uses nucleoside-modified and purified mRNA encoding full-length influenza virus HA formulated in lipid nanoparticles (LNPs). We demonstrate that immunization with HA mRNA-LNPs induces antibody responses against the HA stalk domain of influenza virus in mice, rabbits, and ferrets. The HA stalk-specific antibody response is associated with protection from homologous, heterologous, and heterosubtypic influenza virus infection in mice.
Differential cell division history between neutrophils and macrophages in their development from granulocyte–macrophage progenitors (2006)

The appearance of monocytes before neutrophils in the blood during haematopoietic recovery in myelosuppressive patients is commonly observed, thus suggesting a difference in the cell division history between these two lineages in the differentiation from granulocyte-macrophage (GM) progenitors. We investigated the cell division histories of murine GM progenitors. When analysed by the dye dilution method, GM progenitors gave rise to Gr-1+Fms+ and Gr-1+Fms- cells that passed through similar rounds of cell division during initial 5 d of culture. The Gr-1+Fms+ cells showed morphological features of monocytes, while Gr-1+Fms- cells exhibited an immature morphology of neutrophils. In the subsequent culture, a decline in the number of Gr-1+Fms+ cells was observed, while Gr-1+Fms- cells increased. The proliferation of Gr-1+Fms- cells and no cell division of Gr-1+Fms+ cells were confirmed by DNA staining, Ki-67 expression, membrane dye staining and bromodeoxyuridine incorporation. These Gr-1+Fms- cells acquired mature neutrophil morphology, whereas Gr-1+Fms+ cells became macrophages. These results demonstrate that GM progenitors generate postmitotic monocytes earlier than mature neutrophils. Our data may also offer one explanation for the rapid recovery of monocytes in comparison with neutrophils in the early phase of haematopoietic regeneration.