gebhart/patrepeval huggingface dataset:
Imprecision in Computer Vision (1982)

Visual perception has perplexed researchers in philosophy and psychology for centuries. Now it’s also perplexing computer scientists. Despite persistent efforts by many noted scientists, it is still unclear how our brain “sees” the visual signals received by our eyes [10]. Earlier it was believed that a good understanding of optics, the retinal image, and the anatomy and physiology of eye and brain would unravel the puzzle of visual perception. However, the many advances in these fields have not solved the problem.
Detection of aberrant DNA methylation in unique Prader — Willi syndrome patients and its diagnostic implications (1994)

Most patients with Prader-Willi syndrome have a deletion of 15q11-13 or maternal uniparental disomy for chromosome 15. The shortest region of deletion overlap is presently defined by the gene for the small nuclear ribonucleoprotein N (SNRPN). We have investigated the integrity of SNRPN as well as the methylation status of D15S63 (PW71) in two patients with apparently normal chromosomes 15 of biparental origin. SNRPN is normal in one patient and deleted in the other one. Both patients are intact at the D15S63 locus, but have an abnormal methylation pattern. These results suggest that a DNA sequence close to SNRPN determines the methylation status of D15S63 and that the methylation test does not only detect the common deletions and uniparental disomy, but other rare lesions as well.
RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes (2005)

Notch is a transmembrane receptor that determines cell fates and pattern formation in all animal species. After ligand binding, proteolytic cleavage steps occur and the intracellular part of Notch translocates to the nucleus, where it targets the DNA-binding protein RBP-Jkappa/CBF1. In the absence of Notch, RBP-Jkappa represses Notch target genes through the recruitment of a corepressor complex. We and others have identified SHARP as a component of this complex. Here, we functionally demonstrate that the SHARP repression domain is necessary and sufficient to repress transcription and that the absence of this domain causes a dominant negative Notch-like phenotype. We identify the CtIP and CtBP corepressors as novel components of the human RBP-Jkappa/SHARP-corepressor complex and show that CtIP binds directly to the SHARP repression domain. Functionally, CtIP and CtBP augment SHARP-mediated repression. Transcriptional repression of the Notch target gene Hey1 is abolished in CtBP-deficient cells or after the functional knockout of CtBP. Furthermore, the endogenous Hey1 promoter is derepressed in CtBP-deficient cells. We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes.
Dasatinib (BMS-354825) Tyrosine Kinase Inhibitor Suppresses Invasion and Induces Cell Cycle Arrest and Apoptosis of Head and Neck Squamous Cell Carcinoma and Non–Small Cell Lung Cancer Cells (2005)

This study showed that Src inhibition in HNSCC and NSCLC has antitumor effects in vitro. This suggests that dasatinib would have therapeutic activity against these tumors. Clinical studies in these tumor types are warranted.
Mannose-binding protein gene polymorphism in systemic lupus erythematosus (1995)

Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
All‐Hex Mesh Generation via Volumetric PolyCube Deformation (2011)

Abstract While hexahedral mesh elements are preferred by a variety of simulation techniques, constructing quality all‐hex meshes of general shapes remains a challenge. An attractive hex‐meshing approach, often referred to as sub‐mapping, uses a low distortion mapping between the input model and a PolyCube (a solid formed from a union of cubes), to transfer a regular hex grid from the PolyCube to the input model. Unfortunately, the construction of suitable PolyCubes and corresponding volumetric maps for arbitrary shapes remains an open problem. Our work introduces a new method for computing low‐distortion volumetric PolyCube deformations of general shapes and for subsequent all‐hex remeshing. For a given input model, our method simultaneously generates an appropriate PolyCube structure and mapping between the input model and the PolyCube. From these we automatically generate good quality all‐hex meshes of complex natural and man‐made shapes.
Renaturation of recombinant human neurotrophin‐3 from inclusion bodies using a suppressor agent of aggregation (1998)

Escherichia coli has been widely used in the production of recombinant proteins. One of the drawbacks inherent in this method is that the proteins produced in the cells often form inactive inclusion bodies. Usually, the inclusion bodies can be separated from other cell components, solubilized by denaturants such as guanidine hydrochloride or urea, and then renatured through a refolding process such as dilution or dialysis. However, it has been shown that biologically active recombinant human neurotrophin-3 cannot be obtained at high yield by this procedure due to aggregation and precipitation of the protein. We applied the refolding process using the aggregation suppressor L-arginine in the renaturation of neurotrophin-3, and obtained biologically active neurotrophin-3 at high yield from the inclusion bodies. Consequently, about 10 mg of purified neurotrophin-3 was prepared from 1 litre of culture broth.
Solid‐Phase Methodology for Synthesis of O‐Alkylated Aromatic Oligoamide Inhibitors of α‐Helix‐Mediated Protein–Protein Interactions (2013)

Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).
RDF metadata for XML access control (2003)

In this paper we present an access control framework that provides flexible security granularity for XML documents. RDF statements are used to represent security objects and to express security policy. The concepts of simple security object and association security object are defined. Our model allows to express and enforce access control on XML trees and their associations. Access control rules, corresponding to (s, o, ±a) triples, are represented as RDF statements with properties access type, user, and object. A history file is maintained for each user that allows decision-making using temporal data.
The overactive bladder: neuropharmacological basis of clinical management (1999)

The overactive bladder continues to pose a major challenge to clinicians treating lower urinary tract disorders, not least because our understanding of the pathogenesis of detrusor overactivity is still relatively limited. However, progress in understanding the basis of the overactive bladder is moving steadily forward, accompanied by a growing number of different forms of treatment. New pharmacological treatments and variations in the mode of delivery of older agents offer hope of efficacy with fewer side-effects. Neuromodulation is also offering a viable alternative to surgery in patients unresponsive to medical treatment.
2-Hydroxyethyl Methacrylate (HEMA): Chemical Properties and Applications in Biomedical Fields (1992)

Abstract 2-Hydroxyethyl methacrylate is a monomer with numerous applications. More than 1500 publications have been devoted to this product since 1967,2000 publications or patents mention the corresponding polymer, and a greater number of works involve copolymers incorporating this monomer.
On the Regulation of DNA Replication in Bacteria (1963)

The deoxyribonucleotide sequence containing the genetic information of a cell participates in two distinct chemical processes. In the first one, generally called replication, free deoxyribonucleotides are linearly assembled by specific base-pairing to form an identical sequence, or replica of the original structure. The second process, or transcription, allows the genetic material to perform its physiological functions consisting essentially in the production of specific proteins at a suitable rate. As a first step, transcription involves the production of messengers which carry to the protein-forming-centers the information necessary to specify the structure of the polypeptide chains. Messenger synthesis by DNA is a process probably closely similar to that of replication, with the differences that it involves ribo-, instead of deoxyribonucleotides and that, in all likelihood, only one of the DNA strands is used for copying into an RNA transcript.
Arabidopsis thaliana Centromere Regions: Genetic Map Positions and Repetitive DNA Structure (1997)

The genetic positions of the five Arabidopsis thaliana centromere regions have been identified by mapping size polymorphisms in the centromeric 180-bp repeat arrays. Structural and genetic analysis indicates that 180-bp repeat arrays of up to 1000 kb are found in the centromere region of each chromosome. The genetic behavior of the centromeric arrays suggests that recombination within the arrays is suppressed. These results indicate that the centromere regions of A. thaliana resemble human centromeres in size and genomic organization.
Fluid Mechanics of Heart Valves (2004)

Valvular heart disease is a life-threatening disease that afflicts millions of people worldwide and leads to approximately 250,000 valve repairs and/or replacements each year. Malfunction of a native valve impairs its efficient fluid mechanic/hemodynamic performance. Artificial heart valves have been used since 1960 to replace diseased native valves and have saved millions of lives. Unfortunately, despite four decades of use, these devices are less than ideal and lead to many complications. Many of these complications/problems are directly related to the fluid mechanics associated with the various mechanical and bioprosthetic valve designs. This review focuses on the state-of-the-art experimental and computational fluid mechanics of native and prosthetic heart valves in current clinical use. The fluid dynamic performance characteristics of caged-ball, tilting-disc, bileaflet mechanical valves and porcine and pericardial stented and nonstented bioprostheic valves are reviewed. Other issues related to heart valve performance, such as biomaterials, solid mechanics, tissue mechanics, and durability, are not addressed in this review.
A Fluorescence Assay for Leucine Zipper Dimerization:  Avoiding Unintended Consequences of Fluorophore Attachment (1999)

Formation of α-helical coiled-coil dimers represents one of the simplest examples of a specific protein−protein interaction. This dimerization mode is commonly observed among transcription regulator proteins, where the process is referred to as leucine zipper formation. Inhibitors of leucine zipper dimerization would allow one to control gene expression. As a first step toward identifying such inhibitors, we have developed a fluorescence-based assay for homodimerization of peptides corresponding to the leucine zipper region of the Jun protein. The assay involves attachment of 7-hydroxycoumarin to the N-terminus of the Jun peptide. Upon dimerization, pairs of fluorophores are held near one another, which leads to self-quenching. Disruption of the dimer is signaled by an increase of 7-hydroxycoumarin fluorescence. Development of this assay proved to be more complex than expected, because we found that two commonly used fluorescent tags, pyrene and fluorescein, induce high-order aggregation of leucine zipper−fluorophore conjugates. This aggregation was demonstrated to result from cooperativity between the fluorophore and peptide portions. A third common fluorophore, 7-diethylaminocoumarin, significantly stabilized the Jun homodimer. Of the four fluorophores we examined, 7-hydroxycoumarin caused the least perturbation of leucine zipper peptide behavior.
Neurotrophin p75 Receptor (p75 NTR ) Promotes Endothelial Cell Apoptosis and Inhibits Angiogenesis (2008)

Diabetes impairs endothelial function and reparative neovascularization. The p75 receptor of neurotrophins (p75(NTR)), which is scarcely present in healthy endothelial cells (ECs), becomes strongly expressed by capillary ECs after induction of peripheral ischemia in type-1 diabetic mice. Here, we show that gene transfer-induced p75(NTR) expression impairs the survival, proliferation, migration, and adhesion capacities of cultured ECs and endothelial progenitor cells (EPCs) and inhibits angiogenesis in vitro. Moreover, intramuscular p75(NTR) gene delivery impairs neovascularization and blood flow recovery in a mouse model of limb ischemia. These disturbed functions are associated with suppression of signaling mechanisms implicated in EC survival and angiogenesis. In fact, p75(NTR) depresses the VEGF-A/Akt/eNOS/NO pathway and additionally reduces the mRNA levels of ITGB1 [beta (1) integrin], BIRC5 (survivin), PTTG1 (securin) and VEZF1. Diabetic mice, which typically show impaired postischemic muscular neovascularization and blood perfusion recovery, have these defects corrected by intramuscular gene transfer of a dominant negative mutant form of p75(NTR). Collectively, our data newly demonstrate the antiangiogenic action of p75(NTR) and open new avenues for the therapeutic use of p75(NTR) inhibition to combat diabetes-induced microvascular liabilities.
Myocardial Boring for the Ischemic Heart (1967)

IN 1706, Raymond Vieussens 1 discovered the small openings on the endocardium which communicate with the coronary arteries. Two years later, Thebesius described the numerous openings for venous blood in the auricles and ventricles 2 which are now commonly referred to as the thebesian circulation. In 1933, Wearn 3 demonstrated direct communications between the heart chambers and the myocardial sinusoids, which he called arterioluminal and arteriosinusoidal vessels. In the event of gradual closure of the orifices of the coronary arteries, the thebesian circulation of Wearn's circulation can supply the heart muscle with sufficient blood to enable it to maintain an efficient circulation. 4 Nordenstroem 5 demonstrated the passage of contrast media from the myocardium (myocardiogram) to the left ventricular lumen in a patient with coronary artery stenosis, which he thought might be radiological expression of the thebesian circulation. Thebesian or Wearn's circulation might play an important role in the blood
A rapidly adaptive lossless compression algorithm for high fidelity audio coding (2002)

A new adaptive algorithm for lossless compression of digital audio is presented. The algorithm is derived from ideas from both dictionary coding and source-modeling. An adaptive Lempel-Ziv (1977) style fixed dictionary coder is used to build a source model that fuels an arithmetic coder. As a result, variable length strings drawn from the source alphabet are mapped onto variable length strings that are on average shorter. The authors show that this algorithm outperforms arithmetic coding or Lempel-Ziv coding working alone on the same source (in their experiments the source is an ADPCM quantizer). Adaptation heuristics for the Lempel-Ziv coder, relevant data structures, and a discussion of audio source modeling (entropy estimation) experiments are described. While the algorithm presented herein is designed to be used as a post-compressor in a lossy audio transform coding system, it is well suited for any instance where non-stationary source outputs must be compressed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
On the formulation of the image reconstruction problem in magnetic particle imaging (2013)

In magnetic particle imaging (MPI), the spatial distribution of magnetic nanoparticles is determined by applying various static and dynamic magnetic fields. Due to the complex physical behavior of the nanoparticles, it is challenging to determine the MPI system matrix in practice. Since the first publication on MPI in 2005, different methods that rely on measurements or simulations for the determination of the MPI system matrix have been proposed. Some methods restrict the simulation to an idealized model to speed up data reconstruction by exploiting the structure of an idealized MPI system matrix. Recently, a method that processes the measurement data in x-space rather than frequency space has been proposed. In this work, we compare the different approaches for image reconstruction in MPI and show that the x-space and the frequency space reconstruction techniques are equivalent.
Synergism between Etoposide and 17-AAG in Leukemia Cells: Critical Roles for Hsp90, FLT3, Topoisomerase II, Chk1, and Rad51 (2007)

The repair of potentially lethal DNA damage by etoposide in leukemia cells is dependent on intact and functioning FLT3 especially leukemias with ITD-FLT3. These data suggest a rational therapeutic strategy for FLT3(+) leukemias that combines etoposide or other DNA-damaging agents with Hsp90/FLT3 inhibitors such as 17-AAG.
Microbiota, Disease, and Back to Health: A Metastable Journey (2012)

Alterations in the composition of the commensal microbiota have been observed in many complex diseases. Understanding the basis for these changes, how they relate to disease risk or activity, and the mechanisms by which the symbiotic state of colonization resistance and host homeostasis is restored is critical for future therapies aimed at manipulating the microbiota.
Inducer-responsive expression of the cloned human interferonβ1gene introduced into cultured mouse cells (1982)

A hybrid plasmid was constructed from pSV2-Ecogpt (Mulligan and Berg, 1981) and the cloned 1.8 kilobase chromosomal DNA segment which contains the human interferon (HIFN-beta 1) gene and its flanking sequences. Cultured mouse FM3A cells were transfected by the hybrid plasmid and several Ecogpt+ clones were selected. Southern blot analysis of the DNA from these mouse cell clones showed that two of them contained a few copies of the 1.8 kilobase human DNA. Synthesis of mRNA characteristic of the HIFN-beta 1 mRNA increased as measured by RNA blot analysis when those clones were treated with Newcastle disease virus or with poly(I):poly(C). In addition, the induced mouse cell clones gave rise to the synthesis of human IFN-beta 1. These results suggest the presence of a unique nucleotide sequence in the 1.8 kilobase DNA which is sufficient for the inducer-responsive expression of the human IFN-beta 1 gene.
Passive Protection of Diabetic Rats with Antisera Specific for the Polysaccharide Portion of the Lipopolysaccharide Isolated from Pseudomonas pseudomallei (1994)

Polyclonal and monoclonal antisera raised to tetanus toxoid-conjugated polysaccharide of lipopolysaccharide (lps) and purified lps of Pseudomonas pseudomallei that reacted with a collection of 41 strains of this bacterium from 23 patients are described. The common antigen recognized by these sera was within the polysaccharide component of the lps of the cells. The sera were specific for P pseudomallei in that none of 37 strains of other bacteria, including 20 Gram-negative and three Gram-positive species, were recognized, although cross-reaction occurred using the anticonjugate serum with some strains of Pseudomonas cepacia serotype A, a closely related bacterium. Passive protection studies using a diabetic rat model of P pseudomallei infection showed that partially purified rabbit polyclonal and mouse monoclonal antisera were protective when the median lethal dose was raised by four to five orders of magnitude. The wide distribution of the polysaccharide antigen among isolates of P pseudomallei used in this study and the protective role of antibody to the conjugated polysaccharide antigen suggest potential as a vaccine.
PREVALENCIA DE LACTANCIA MATERNA EN ESPAÑA (2019)

La lactancia materna ofrece numerosos beneficios tanto al recien nacido como a la madre. La OMS recomienda una lactancia materna exclusiva hasta el sexto mes de vida y una lactancia mixta hasta los 2 anos o mas. Pese a no ser datos oficiales, la prevalencia estimada en Espana de LM es de 71% a las 6 semanas de vida, 66.5% a los 3 meses, 49.6% a los 6 meses y 20% al ano de vida. Los principales factores asociados al abandono de la lactancia materna son: parto traumatico, padecer depresion postparto u otra afeccion psicologica, incorporacion temprana al trabajo, problemas con la lactancia y bajo nivel educacional. Como enfermeros podemos incidir en la educacion maternal respecto a la forma correcta de enganche y succion asi como la posicion a la hora de amamantar, ademas de proporcionar apoyo emocional. Palabras clave: lactancia materna, abandono, temprano, prevalencia, exclusiva, inicio, enfermera, factor.
Provenance-aware storage systems (2006)

A Provenance-Aware Storage System (PASS) is a storage system that automatically collects and maintains provenance or lineage, the complete history or ancestry of an item. We discuss the advantages of treating provenance as meta-data collected and maintained by the storage system, rather than as manual annotations stored in a separately administered database. We present a PASS implementation, discussing the challenges and performance cost, and the new functionality it enables. We show that with reasonable overhead, we can provide useful functionality not available in today’s file systems or provenance management systems.
Swelling Behavior and Mechanical Properties of Chemically Cross-Linked Gelatin Gels for Biomedical Use (1999)

Cross-linked gelatin gels are used as biomaterials in living tissues, either as bioadhesives or as devices for sustained drug release. As these applications involve surgical insertion of gels, the effect of cross-linking on mechanical properties is relevant. The effect of cross-linking on the gel water uptake is also relevant for the kinetics of drug release. Equally important is the influence of initial amounts of gelatin in the gelling solutions. We investigated the influence of cross-linking (with glutaraldehyde) and of gelatin content upon the equilibrium water content and tensile properties of resulting gels. A range of gels was prepared with gelatin contents of 10 to 40% wt, and cross-linked with 2.5 to 50% wt glutaraldehyde. The increase in gelatin content and degree of cross-linking reduced the water uptake of gels from about 60-65% wt to about 50% wt. The tensile characteristics were differentially affected. While the increase of cross-linking induced a decrease of toughness and elasticity and an increase of stiffness, it did not affect the ultimate strength of gels. On the contrary, the increase of gelatin content induced a definite increase of the ultimate strength but did not significantly affect the other properties.
Information archiving with bookmarks (1998)

Article Information archiving with bookmarks: personal Web space construction and organization Share on Authors: David Abrams Perceptual Robotics, Inc., 1840 Oak Ave., Evanston, IL Perceptual Robotics, Inc., 1840 Oak Ave., Evanston, ILView Profile , Ron Baecker Knowledge Media Design Institute, University of Toronto, Toronto, ON M5S 1A4 Knowledge Media Design Institute, University of Toronto, Toronto, ON M5S 1A4View Profile , Mark Chignell Interactive Media Laboratory, University of Toronto, Toronto, ON M5S 1A4 Interactive Media Laboratory, University of Toronto, Toronto, ON M5S 1A4View Profile Authors Info & Claims CHI '98: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsJanuary 1998 Pages 41–48https://doi.org/10.1145/274644.274651Published:01 January 1998 163citation2,116DownloadsMetricsTotal Citations163Total Downloads2,116Last 12 Months63Last 6 weeks14 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access