gebhart/patrepeval huggingface dataset:
Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis (2009)

Anemia of cancer and chronic inflammatory diseases is a frequent complication affecting quality of life. For cancer patients it represents a particularly bad prognostic. Low level of erythropoietin is considered as one of the causes of anemia in these pathologies. The deficiency in erythropoietin production results from pro-inflammatory cytokines effect. However, few data is available concerning molecular mechanisms involved in cytokine-mediated anemia. Some recent publications have demonstrated the direct effect of pro-inflammatory cytokines on cell differentiation towards erythroid pathway, without erythropoietin defect. This suggested that pro-inflammatory cytokine-mediated signaling pathways affect erythropoietin activity. They could interfere with erythropoietin-mediated signaling pathways, inducing early apoptosis and perturbing the expression and regulation of specific transcription factors involved in the control of erythroid differentiation. In this review we summarize the effect of tumor necrosis factor (TNF)alpha, TNF-related apoptosis-inducing ligand (TRAIL), and interferon (IFN)-gamma on erythropoiesis with a particular interest for molecular feature.
Angular-momentum biasing: A new paradigm for linear, magnetic-free, non-reciprocal devices (2014)

A paradigm to obtain magnetic-free, linear non-reciprocal devices is presented based on biasing with the angular-momentum vector, achieved either by directly spinning a loading material or by imparting spatiotemporal modulation over a substrate. This technique is shown to be applicable to any range of the electromagnetic spectrum, and even to different types of waves, such as acoustic waves. Furthermore, it can be realized with integration-friendly materials, such as metals and semiconductors, thus opening a path for the much sought realization of integrated, compact and linear non-reciprocal components.
A potential RNA drug target in the hepatitis C virus internal ribosomal entry site (2000)

Subdomain IlId from the hepatitis C virus (HCV) internal ribosome entry site (IRES) has been shown to be essential for cap-independent translation. We have conducted a structural study of a 27-nt fragment, identical in sequence to IlId, to explore the structural features of this subdomain. The proposed secondary structure of IlId is comprised of two 3 bp helical regions separated by an internal loop and closed at one end by a 6-nt terminal loop. NMR and molecular modeling were used interactively to formulate a validated model of the three-dimensional structure of IlId. We found that this fragment contains several noncanonical structural motifs and non-Watson-Crick base pairs, some of which are common to other RNAs. In particular, a motif characteristic of the rRNA alpha-sarcin/ricin loop was located in the internal loop. The terminal loop, 5'-UUGGGU, was found to fold to form a trinucleotide loop closed by a trans-wobble U.G base pair. The sixth nucleotide was bulged out to allow stacking of this U.G pair on the adjacent helical region. In vivo mutational analysis in the context of the full IRES confirmed the importance of each structural motif within IIId for IRES function. These findings may provide clues as to host cellular proteins that play a role in IRES-directed translation and, in particular, the mechanism through which host ribosomes are sequestered for viral function.
Iodinated Contrast Media and Their Adverse Reactions (2008)

Cross-use of technology between nuclear medicine and radiology technologists is expanding. The growth of PET/CT and the increasing use of intravenous contrast agents during these procedures bring the nuclear medicine technologist into direct contact with these agents and their associated complications. A basic understanding of the occurrence, risk factors, clinical features, and management of these procedures is of increasing importance to the nuclear medicine technologist. After reading this article, the technologist will be able to list the factors that increase the risk of contrast reactions; understand ways to minimize the occurrence of contrast reactions; and develop a plan to identify, treat, and manage the reactions effectively.
World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites (2008)

The World Health Organization (WHO) estimates that >2 million people will have started antiretroviral therapy (ART) by the end of 2006. As the development of some HIV drug resistance (HIVDR) is inevitable in populations taking ART, the emergence of HIVDR must be balanced against the benefits of providing ART, including improved health outcomes and decreased HIV/AIDS-associated morbidity and mortality. ART programmes should operate to minimize the emergence of HIVDR in populations receiving therapy and HIVDR itself must be monitored to ensure ongoing regimen efficacy. ART regimens in resource-limited settings are usually selected at the national level following a public health approach: generally only one first-line regimen with alternate regimen(s) incorporating within-class drug substitutions are available in the public sector. The WHO has developed a population-based HIVDR assessment and prevention strategy, which includes standardized HIVDR monitoring surveys in populations receiving first-line ART at sentinel sites. The WHO surveys monitor HIVDR prevention in sentinel sites by utilizing a standardized, minimum-resource prospective survey methodology to assess the success of adult and paediatric ART sites in preventing HIVDR emergence during the first year of ART. The surveys also identify associated factors that can be addressed at the level of the ART site or programme. WHO HIVDR monitoring surveys are designed to be integrated easily into a country's ongoing, routine HIV-related evaluation activities. Performed regularly at representative sites, the data generated will inform evidence-based decision making regarding national and global ART regimen selection and minimize the emergence of HIVDR at a population level.
Executing stream joins on the cell processor (2007)

Low-latency and high-throughput processing are key requirements of data stream management systems (DSMSs). Hence, multi-core processors that provide high aggregate processing capacity are ideal matches for executing costly DSMS operators. The recently developed Cell processor is a good example of a heterogeneous multi-core architecture and provides a powerful platform for executing data stream operators with high-performance. On the down side, exploiting the full potential of a multi-core processor like Cell is often challenging, mainly due to the heterogeneous nature of the processing elements, the software managed local memory at the co-processor side, and the unconventional programming model in general.

In this paper, we study the problem of scalable execution of windowed stream join operators on multi-core processors, and specifically on the Cell processor. By examining various aspects of join execution flow, we determine the right set of techniques to apply in order to minimize the sequential segments and maximize parallelism. Concretely, we show that basic windows coupled with low-overhead pointer-shifting techniques can be used to achieve efficient join window partitioning, column-oriented join window organization can be used to minimize scattered data transfers, delay-optimized double buffering can be used for effective pipelining, rate-aware batching can be used to balance join throughput and tuple delay, and finally SIMD (single-instruction multiple-data) optimized operator code can be used to exploit data parallelism. Our experimental results show that, following the design guidelines and implementation techniques outlined in this paper, windowed stream joins can achieve high scalability (linear in the number of co-processors) by making efficient use of the extensive hardware parallelism provided by the Cell processor (reaching data processing rates of a 13 GB/sec) and significantly surpass the performance obtained form conventional high-end processors (supporting a combined input stream rate of 2000 tuples/sec using 15 minutes windows and without dropping any tuples, resulting in a 8.3 times higher output rate compared to an SSE implementation on dual 3.2Ghz Intel Xeon).
The Alkyltert-Butyl Ether Intermediate 2-Hydroxyisobutyrate Is Degraded via a Novel Cobalamin-Dependent Mutase Pathway (2006)

Fuel oxygenates such as methyl and ethyl tert-butyl ether (MTBE and ETBE, respectively) are degraded only by a limited number of bacterial strains. The aerobic pathway is generally thought to run via tert-butyl alcohol (TBA) and 2-hydroxyisobutyrate (2-HIBA), whereas further steps are unclear. We have now demonstrated for the newly isolated beta-proteobacterial strains L108 and L10, as well as for the closely related strain CIP I-2052, that 2-HIBA was degraded by a cobalamin-dependent enzymatic step. In these strains, growth on substrates containing the tert-butyl moiety, such as MTBE, TBA, and 2-HIBA, was strictly dependent on cobalt, which could be replaced by cobalamin. Tandem mass spectrometry identified a 2-HIBA-induced protein with high similarity to a peptide whose gene sequence was found in the finished genome of the MTBE-degrading strain Methylibium petroleiphilum PM1. Alignment analysis identified it as the small subunit of isobutyryl-coenzyme A (CoA) mutase (ICM; EC 5.4.99.13), which is a cobalamin-containing carbon skeleton-rearranging enzyme, originally described only in Streptomyces spp. Sequencing of the genes of both ICM subunits from strain L108 revealed nearly 100% identity with the corresponding peptide sequences from M. petroleiphilum PM1, suggesting a horizontal gene transfer event to have occurred between these strains. Enzyme activity was demonstrated in crude extracts of induced cells of strains L108 and L10, transforming 2-HIBA into 3-hydroxybutyrate in the presence of CoA and ATP. The physiological and evolutionary aspects of this novel pathway involved in MTBE and ETBE metabolism are discussed.
Synthesis of Some Novel Bis 1,3,4-Oxadiazole Fused Azo Dye Derivatives as Potent Antimicrobial Agents (2011)

bis(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)azo dyes were synthesized by multistep reaction sequences, which is diazotized and coupled with different napthols and quinoline. Structure of newly synthesized compounds were characterized and confirmed by IR, NMR and Mass spectral studies. The newly synthesized azo dye fused with (5-(furan-2-yl)-1,3,4- oxadiazole) were screened for their acute toxicity and gross behavioral studies and in-vitro anti-microbial activity. Synthesized compounds exhibit significant biological activity and can certainly hold greater promise in discovering safer biologically active molecules.
Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide (1998)

Bacterial lipopolysaccharide (LPS) induces activation of the transcription factor nuclear factor kappaB (NF-kappaB) in host cells upon infection. LPS binds to the glycosylphosphatidylinositol (GPI)- anchored membrane protein CD14, which lacks an intracellular signaling domain. Here we investigated the role of mammalian Toll-like receptors (TLRs) as signal transducers for LPS. Overexpression of TLR2, but not TLR1, TLR4, or CD14 conferred LPS inducibility of NF-kappaB activation in mammalian 293 cells. Mutational analysis demonstrated that this LPS response requires the intracellular domain of TLR2. LPS signaling through TLR2 was dependent on serum which contains soluble CD14 (sCD14). Coexpression of CD14 synergistically enhanced LPS signal transmission through TLR2. In addition, purified recombinant sCD14 could substitute for serum to support LPS-induced TLR2 activation. LPS stimulation of TLR2 initiated an interleukin 1 receptor-like NF-kappaB signaling cascade. These findings suggest that TLR2 may be a signaling component of a cellular receptor for LPS.
Dynamic user task scheduling for mobile robots (2011)

We present our efforts to deploy mobile robots in office environments, focusing in particular on the challenge of planning a schedule for a robot to accomplish user-requested actions. We concretely aim to make our CoBot mobile robots available to execute navigationalbased tasks requested by users, such as telepresence, and picking up and delivering messages or objects at different locations. We contribute an efficient webbased approach in which users can request and schedule the execution of specific tasks. The scheduling problem is converted to a mixed integer programming problem. The robot executes the scheduled tasks using a synthetic speech and touch-screen interface to interact with users, while allowing users to follow the task execution online.
Essential oil composition, phenolic content, antioxidant, and antimicrobial activity of cultivatedSatureja rechingeriJamzad at different phenological stages (2015)

Satureja rechingeri is a rare endemic and endangered species found in Iran. Its propagation, variations in essential oil and phenolic content, as well as antioxidant and antimicrobial activities at different phenological stages are reported in this study. The chemical composition of essential oils obtained by hydro-distillation from the aerial parts were determined by GC and GC-MS. A total of 47 compounds were identified in the essential oils of S. rechingeri at different phenological stages. The major components of all oils were carvacrol (83.6%-90.4%), p-cymene (0.8%-2.9%) and γ-terpinene (0.6%-2.4%). The total phenolic content and the antioxidant activity of methanolic extracts were determined with the Folin-Ciocalteau reagent and by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) assay, respectively. Total phenols varied from 35.5 to 37.5 mg gallic acid equivalents/g dry weight (dw), and IC50 values in the radical scavenging assay ranged from 46.2 to 50.2 mg/mL, while those in the FRAP assay were between 49.6 and 52.5 μM quercetin equivalents/g dw. By the disc diffusion method and by determination of the minimum inhibitory concentrations (MIC), the essentials oils of the various phenological stages were found to have high activities against four medically important pathogens.
High-Efficiency DC-DC Converter With High Voltage Gain and Reduced Switch Stress (2007)

In this paper, a high-efficiency dc-dc converter with high voltage gain and reduced switch stress is proposed. Generally speaking, the utilization of a coupled inductor is useful for raising the step-up ratio of the conventional boost converter. However, the switch surge voltage may be caused by the leakage inductor so that it will result in the requirement of high-voltage-rated devices. In the proposed topology, a three-winding coupled inductor is used for providing a high voltage gain without extreme switch duty-cycle and enhancing the utility rate of magnetic core. Moreover, the energy in the leakage inductor is released directly to the output terminal for avoiding the phenomenon of circulating current and the production of switch surge voltage. In addition, the delay time formed with the cross of primary and secondary currents of the coupled inductor is manipulated to alleviate the reverse-recovery current of the output diode. It can achieve the aim of high-efficiency power conversion. Furthermore, the closed-loop control methodology is utilized in the proposed scheme to overcome the voltage drift problem of the power source under the variation of loads. Some experimental results via an example of a proton exchange membrane fuel cell power source with 250-W nominal rating are given to demonstrate the effectiveness of the proposed power conversion strategy
[The distribution of antibiotically-resistant organisms in the environment with special attention to salmonellae]. (1996)

Antibiotic resistant determinants (R) prevail in environmental bacteria independent of antibiotic application in human and veterinary medicine als well as in agriculture. Due to horizontal gene transfer (plasmids) the spread of R. determinants to pathogenic bacteria occur in relation to selection pressure. Since salmonella bacteria have been found to persist in environmental habitats for a long time they will serve as recipients as a reservoir (donors).
Effects of propranolol on bone metabolism in the rat (1991)

Propranolol, a nonspecific beta-blocker has many physiologic effects. Its effects on bone in vivo are unknown, although beta receptor sites have been found on osteoblasts. In this study, the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation. In a group of nonsurgical rats, propranolol treatment increased femoral torsional strength on biomechanical testing. In the rat surgical model used, right femora were fixed to a polyethylene plate and then defects were created mid-diaphysis and subsequently filled with demineralized bone matrix. These rats (defect rats) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days. In the defect rats, increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol-treated groups. Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol-treated rats revealed increased callus and bone union. The results of this study indicate that propranolol treatment can significantly affect bone properties.
Generation of band-specific painting probes from a single microdissected chromosome (1993)

We have developed a modified strategy for the generation of regional probes for human chromosomes by microdissection and degenerate oligonucleotide primed PCR. This modification dramatically increases the efficiency of amplification by pretreatment of the dissected chromatin with topoisomerase I (Topo I) before PCR. This protocol has enabled us to construct region-specific probes for fluorescence in situ hybridization (FISH) from a single microdissected chromosome. Results are presented which convincingly demonstrate that this new method generates high intensity region-specific FISH probes, while at the same time significantly decreasing the time-consuming and labor-intensive aspects of microdissection. The reduction of the number of copies required to generate a useful probe also significantly decreases the risk of contamination during the microdissection process. We believe this advance will allow microdissection to be more widely used in the cytogenetic analysis of chromosome rearrangements in both cancer and hereditary diseases. In addition, this method now makes it possible to construct a series of non-overlapping band-specific DNA microclone libraries to provide complete coverage of individual chromosomes for physical mapping.
The Index of Cognitive Activity: measuring cognitive workload (2003)

The Index of Cognitive Activity is an innovative technique that provides an objective psychophysiological measurement of cognitive workload. As users operate in increasingly complex environments, it is essential that the designers of these environments understand the cognitive demands placed on the users. The Index of Cognitive Activity (ICA) provides an important estimate of the levels of cognitive effort of the user. The ICA is based on changes in pupil dilation that occur as a user interacts with a visual display. The Index is described, and several applications are presented.
Herpes simplex virus type 2 inhibition of Fas ligand expression (1996)

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are common human pathogens. In this report we demonstrate the capacity of HSV-2, but not HSV-1, to inhibit the activity and cell surface expression of Fas ligand, an important molecule involved in T-cell apoptosis and cell-mediated cytotoxicity. Cells infected with HSV-2 retained Fas ligand intracellularly instead of expressing it on the cell surface. Addition of anti-Fas antibodies markedly inhibited HSV-2 viral production, suggesting that the capacity of the virus to regulate Fas ligand expression, and thereby programmed cell death, may represent a powerful mechanism for the virus to enhance viral replication.
Plastic Resin Pellets as a Transport Medium for Toxic Chemicals in the Marine Environment (2000)

Plastic resin pellets (small granules 0.1-0.5 centimeters in diameter) are widely distributed in the ocean all over the world. They are an industrial raw material for the plastic industry and are unintentionally released to the environment both during manufacturing and transport. They are sometimes ingested by seabirds and other marine organisms, and their adverse effects on organisms are a concern. In the present study, PCBs, DDE, and nonylphenols (NP) were detected in polypropylene (PP) resin pellets collected from four Japanese coasts. Concentrations of PCBs (4-117 ng/g), DDE (0.16-3.1 ng/g), and NP (0.13-16 microg/g) varied among the sampling sites. These concentrations were comparable to those for suspended particles and bottom sediments collected from the same area as the pellets. Field adsorption experiments using PP virgin pellets demonstrated significant and steady increase in PCBs and DDE concentrations throughout the six-day experiment, indicating that the source of PCBs and DDE is ambient seawater and that adsorption to pellet surfaces is the mechanism of enrichment. The major source of NP in the marine PP resin pellets was thought to be plastic additives and/or their degradation products. Comparison of PCBs and DDE concentrations in mari
中国、印度、苏联和美国早期的制盐方法 (1990)

由于欧洲的制盐方法受到有限的资源,以及少数国家重商主义者制定的政策的影响,这些制盐方法的历史给人的印象是:与中国、印度、苏联和美国等大陆性国家所采用的方法略有不同。各国都拥有各种各样的盐源。由于这些国家仅仅拥有基本的运输系统,而这种状况一直持续到19世纪,因此它们特别明瞭地展现出了各种各样、持续不变的制盐方法。 迄止1935年,大约80％的中国盐是从海里获得的。P·泽特可夫认为能够断定一
Wide-Area Demand-Side Control for Inter-Area Oscillation Mitigation in Power Systems (2018)

Inter-area oscillations have severely limited maximum power transfer among different areas in large-scale interconnected power grid. If not quickly damped as soon as possible, they may cause system breakup and even lead to large cascading blackouts. To increase the damping of inter-area oscillations, both power system stabilizer (PSS) and flexible AC transmission system (FACTS) controller have been widely considered, which affect the real power flow indirectly. However, the effectiveness of these controllers is restricted to the neighborhood of a prescribed set of operating conditions. In this paper, wide-area demand-side control is developed to directly modulate the real power of end-user loads for oscillation mitigation. The proposed control strategy is implemented in a hierarchical manner. At the device layer, individual end-user loads independently turn ON or OFF in response to the broadcasted signals from the coordinator during the real time. At the supervisory layer, autonomous responses of end-user loads are coordinated to ensure the desired power modulation. The effectiveness of the proposed wide-area demand-side control in improving small-signal stability is illustrated by simulations on a large-scale test system.