gebhart/patrepeval huggingface dataset:
Real-time deformation, registration and tracking of solids based on physical simulation (2014)

This paper proposes a novel approach to registering deformations of 3D non-rigid objects for Augmented Reality applications. Our prototype is able to handle different types of objects in real-time regardless of their geometry and appearance (with and without texture) with the support of an RGB-D camera. During an automatic offline stage, the model is processed in order to extract the data that serves as input for a physics-based simulation. Using its output, the deformations of the model are estimated by considering the simulated behaviour as a constraint. Furthermore, our framework incorporates a tracking method based on templates in order to detect the object in the scene and continuously update the camera pose without any user intervention. Therefore, it is a complete solution that extends from tracking to deformation formulation for either textured or untextured objects regardless of their geometrical shape. Our proposal focuses on providing a correct visual with a low computational cost. Experiments with real and synthetic data demonstrate the visual accuracy and the performance of our approach.
Characterizing CGI‐94 (comparative gene identification‐94) which is down‐regulated in the hippocampus of early stage Alzheimer's disease brain (2002)

The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains. Here we describe a new protein, CGI-94, that is down-regulated at the mRNA level in the hippocampus of early stage AD brain. Transfection experiments with CGI-94 as a green fluorescent protein (GFP)-fusion-protein show that this protein is translocated into the nucleus of the cell. The finding that this protein, which has a bipartite nuclear localization signal, is also observed in the cytoplasm and extracellular space points to a multifunctional protein. Immunohistochemical analyses reveal that CGI-94 is mainly expressed in neurons of the hippocampal formation and the cortex but not in the cerebellar nucleus. In conclusion, the expression of the nucleolar phosphoprotein CGI-94 appears to be disturbed in early processes of neuronal degeneration.
Hemopoiesis of the cultured whole mouse embryo. (1979)

In vitro cultured murine embryos provide a valuable methodology for studying the ontogeny of hemopoiesis in mammalian embryos. Under improved conditions, 49% of mouse embryos cultured from the blastocyst stage reached the early somite stage. The development of the embryo was arrested at different stages by omitting human cord serum from the culture medium at specific times. These observations suggest the appearance and differentiation of the first hemopoietic cells in the mouse yolk sac to be independent of a normal embryo. In the yolk sac of all cultured mouse embryos, hemopoietic cell differentiated into a major cell type, erythroblasts, and minor cell types such as monocytes, macrophages, and granulocytic cells. A small number of hemopoietic cells remained undifferentiated.
Design of BFDM/OQAM systems based on biorthogonal modulated filter banks (2002)

A new system of multicarrier modulation is described which takes advantage of the biorthogonality property to generalize the OFDM/OQAM technique into a biorthogonal frequency division multiplex scheme named BFDM/OQAM. A discrete-time analysis of this scheme leads to a discrete model of modulated transmultiplexer. Using a polyphase decomposition of this transmultiplexer, and assuming a distortion-free channel, we determine the mathematical conditions on the prototype filter allowing an exact cancellation of intersymbol and interchannel interference. Then, computationally efficient realizations of the modulators and demodulators are given. Lastly, some design examples are provided illustrating respective advantages of BFDM/OQAM and OFDM/OQAM.
Morphological features of the P-waves at surface electrocardiogram as surrogate to mechanical function of the left atrium following a successful modified maze procedure (2013)

Absent LA mechanical contraction following the modified maze operation may be accompanied by a distinguished pattern of the P-waves on the surface ECG.
Controlled Li doping of Si nanowires by electrochemical insertion method (1999)

Si nanowires (NWs) were doped with large amounts of Li+ ions by an electrochemical insertion method at room temperature. Si NWs with different doping levels were obtained by controlling the discharging/charging of Li/Si NWs cell. The microstructures of Si NWs with different doses of Li+ ions were investigated by high-resolution electron microscopy. The crystalline structure of the Si NWs was destroyed gradually with the increasing of Li+ ion dose. When the Li+ ions were extracted from the amorphous Li-doped Si NWs by the same electrochemical method, local ordering of atoms occurred and recrystallization was observed. The photoluminescence peak and intensity of Li+-doped Si NWs are closely related to the doping dose.
(Z)-Tamoxifen and Tetrasubstituted Alkenes and Dienes via a Regio- and Stereospecific Three-Component Magnesium Carbometalation Palladium(0) Cross-Coupling Strategy (2003)

[reaction: see text] The synthesis of various tetrasubstituted alkenes and dienes in a regio- and stereocontrolled manner is described. This three-component coupling strategy involves the addition of Grignard reagents to propargyl alcohols followed by palladium(0)-mediated cross-coupling with aryl or vinyl halides. This protocol has been applied to the synthesis of (Z)-Tamoxifen and related mimics.
MPEG splicing and bandwidth management (1997)

The issue of splicing programs in MPEG transport streams has been widely discussed. This paper reviews the problems encountered when splicing elementary streams and discusses the wider related system issues. A technique for splicing video streams by managing the bandwidth allocation in the multiplex is described and its benefits explained.
Randomized phase III study of platinum-doublet chemotherapy followed by gefitinib versus continued platinum-doublet chemotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC): Results of West Japan Thoracic Oncology Group trial (WJTOG (2008)

LBA8012 Background: Gefitinib is a small molecule inhibitor of the EGFR tyrosine kinase. When combined with chemotherapy, no survival gain was observed compared to chemotherapy alone (INTACT I and II). We have conducted a randomized phase III trial to evaluate whether gefitinib improves survival as maintenance therapy after platinum-doublet chemotherapy in pts with advanced NSCLC. Methods: Chemotherapy-naïve pts with advanced stage (IIIB/IV) NSCLC, ECOG PS of 0–1, and adequate organ functions were randomized to either, A) platinum-doublet chemotherapy (Carboplatin AUC 6+Paclitaxel 200mg/m2 day1 Q3w, Cisplatin 80mg/m2 day1+Irinotecan 60mg/m2 day1,8,15 Q4W, Cisplatin 80mg/m2 day1+Vinorelbine 25mg/m2 day1,8 Q3W, Cisplatin 80mg/m2 + Docetaxel 60mg/m2 day1 Q3W, or Cisplatin 80mg/m2 day1+Gemcitabine 1000mg/m2 day1, 8 Q3W) up to 6 cycles or B) platinum-doublet chemotherapy for 3 cycles followed by gefitinib 250 mg orally once daily. Pts were stratified by disease stage, gender, histology and chemotherapy regimens. The primary endpoint was overall survival (OS); secondary endpoints include progression-free survival (PFS), response rate (RR), safety and QOL. A sample size of 300 pts per group was estimated on the basis of a projected median survival of 9 months (m) in arm A and 11.4 m in arm B, with a power of 80% at 0.05 two-sided alpha to compare both group. Results: 603 pts were randomized between March 2003 and May 2005, and pt characteristics were equally distributed between arms. There was a statistically significant improvement in PFS (HR, 0.68; 95% CI, 0.57–0.80; P<0.001) in arm B; however, OS result did not reach statistical significance (P=0.10). In a pre-specified analysis of OS by histologic groups, arm B had significantly better OS than arm A in adenocarcinoma histology (n=467; HR, 0.79; 95% CI, 0.65–0.98; P=0.03). Conclusions: These results demonstrate a possible clinical benefit for maintenance therapy of gefitinib, especially in adenocarcinoma histology. No significant financial relationships to disclose.
Ristocetin - A New Tool in the Investigation of Platelet Aggregation (1971)

Summary 1. The antibotic, Ristocetin, causes precipitation of fibrinogen from platelet poor plasma, as well as platelet aggregation. 2. The precise mechanism of Ristocetin’s effect on platelets has not been elucidated, but it has been shown to initiate ADP release, which may contribute in part to its aggregating ability. 3. Ristocetin has been shown to produce aggregation in platelet rich plasma from thrombasthenic patients. 4. Three patients with Von Willebrand’s disease were examined. In 2, Ristocetin caused no platelet aggregation whatsoever, whilst the third aggregated normally. It is suggested, on this basis, that Von Willebrand’s disease may be subdivided into two types and that Ristocetin could prove to be a valuable technique for further study of this group of disorders.
Object identity (1986)

Identity is that property of an object which distinguishes each object from all others. Identity has been investigated almost independently in general-purpose programming languages and database languages. Its importance is growing as these two environments evolve and merge. We describe a continuum between weak and strong support of identity, and argue for the incorporation of the strong notion of identity at the conceptual level in languages for general purpose programming, database systems and their hybrids. We define a data model that can directly describe complex objects, and show that identity can easily be incorporated in it. Finally, we compare different implementation schemes for identity and argue that a surrogate-based implementation scheme is needed to support the strong notion of identity.
An Essential Role of N-Terminal Arginylation in Cardiovascular Development (2002)

The enzymatic conjugation of arginine to the N-termini of proteins is a part of the ubiquitin-dependent N-end rule pathway of protein degradation. In mammals, three N-terminal residues-aspartate, glutamate, and cysteine-are substrates for arginylation. The mouse ATE1 gene encodes a family of Arg-tRNA-protein transferases (R-transferases) that mediate N-terminal arginylation. We constructed ATE1-lacking mouse strains and found that ATE1-/- embryos die with defects in heart development and in angiogenic remodeling of the early vascular plexus. Through biochemical analyses, we show that N-terminal cysteine, in contrast to N-terminal aspartate and glutamate, is oxidized before its arginylation by R-transferase, suggesting that the arginylation branch of the N-end rule pathway functions as an oxygen sensor.
UNIX Host Administration in a Hererogeneous Distributed Computing Environment (1996)

Managing a computing environment consisting of hundreds of systems from multiple vendors and hundreds of users dispersed over several buildings of a research campus is a complex task. We developed a data model for representing pertinent information about our computing environment and implemented this model in a database that tracks equipment, users, and accounts. We created software that automates much of the data collection, maintains the database, and provides easy access to commonly requested information. For example, a user can find out which hosts he or she has an account on, or learn the hardware and software configuration of any host on the local network. We also created software that automates many of the tasks involved in account creation, deletion, and modification, which reduces the burden on support staff by allowing privileged users to manage accounts on their own systems.
Partial pulpotomy in young permanent teeth with deep carious lesions (1993)

The material comprised 37 young posterior teeth with deep carious lesions and exposed pulps, treated with partial pulpotomy and dressed with calcium hydroxide. The teeth were divided into two groups. Group 1 consisted of 31 teeth with no clinical or radiographic symptoms before treatment, Group 2 of 6 teeth with temporary pain, widened periodontal space periapically and/or productive osteitis, i.e. increased density of the surrounding alveolar bone. After an observation time of 24 to 140 months (mean = 56 months), healing had occurred in 29 of 31 teeth in Group 1 (93.5%) and in 4 of 6 teeth in Group 2. It was concluded that the present, as well as previously reported results indicate that partial pulpotomy may be an adequate treatment for young permanent molars with a carious exposure, although more studies are needed before the treatment can be recommended for routine clinical use.
Effect of chemically‐induced, cloned‐gene expression on protein synthesis in E. Coli (1991)

Earlier experiments in our lab investigated the metabolic limitations of cloned-gene expression in bacterial cells (for over-production of beta-lactamase). These experiments showed that the steady-state concentration of ribosomal RNA decreased upon plasmid amplification while both the synthesis rate and steady-state beta-lactamase mRNA level increased significantly. This appeared to indicate substantial limitation exist within the transnational machinery of the bacterial cell at high copy numbers. To establish the generality of this phenomenon, the impact increasing protein expression from pa plasmid by chemically inducing a strong promoter while maintaining constant copy number has been investigated. A plasmid has been constructed which contains the lacZ gene under control of the tac promoter and contains the parB stability locus to maintain plasmid stability. Using this vector, beta-galactosidase expression in chemostat cultures operated at specific growth rates of 0.6 h(-1) was induced with IPTG such that enzyme activity was varied over a 460-fold range. When fully induced beta-galactosidase protein production represented 14 wt % of total cell protein. As transcription was induced, the synthesis rate of the beta-galactosidase mRNA increased 42-fold while the steady-state level of beta-galactosidase mRNA increased only fourfold. This indicates stability may play a larger role for beta-galactosidase expression with a strong promoter than seen with beta-lactamase production in the elevated copy number system. Furthermore, rRNA synthesis rates increased at high expression rates as seen in the copy number experiments. However, unlike the amplified-plasmid system, the steady-state levels of rRNA increased as well. Since the total protein levels closely followed the steady-state level of eRNA, transnational limitations are again suggested for the chemically induced transcription system.
Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke (1998)

Insulin-like growth factors I and II (IGF-I and IGF-II) play an important role in normal growth and brain development and protect brain cells from several forms of injury. The effects of IGFs are mediated by type-I and type-II receptors and modulated by potentially six specific binding proteins that form high-affinity complexes with IGFs in blood and cerebrospinal fluid (CSF) and under most circumstances inactivate them. Because brain injury is commonly associated with increases in IGFs and their associated binding proteins, we hypothesized that displacement of this large "pool" of endogenous IGF from the binding proteins would elevate "free" IGF levels to elicit neuroprotective effects comparable to those produced by administration of exogenous IGF. A human IGF-I analog [(Leu24, 59, 60, Ala31)hIGF-I] with high affinity to IGF-binding proteins (Ki = 0.3-3.9 nM) and no biological activity at the IGF receptors (Ki = >10,000 nM) increased the levels of "free, bioavailable" IGF-I in the CSF. Intracerebroventricular administration of this analog up to 1h after an ischemic insult to the rat brain had a potent neuroprotective action comparable to IGF-I. This novel strategy for increasing "free" IGF levels in the brain may be useful for the treatment of stroke and other neurodegenerative diseases.
Diagnostic Evaluation of HER-2 as a Molecular Target: An Assessment of Accuracy and Reproducibility of Laboratory Testing in Large, Prospective, Randomized Clinical Trials (2005)

Compared with the HER-2 status determined at centralized BCIRG reference laboratories, these results indicate superiority of FISH to accurately and reproducibly assess tumors for the HER-2 alteration at outside/local laboratories for entry to clinical trials.
Arylsulfur Pentafluorides (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTArylsulfur PentafluoridesWilliam A. SheppardCite this: J. Am. Chem. Soc. 1962, 84, 16, 3064–3072Publication Date (Print):August 1, 1962Publication History Published online1 May 2002Published inissue 1 August 1962https://doi.org/10.1021/ja00875a006RIGHTS & PERMISSIONSArticle Views953Altmetric-Citations127LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (835 KB) Get e-Alertsclose Get e-Alerts
Topologies of Single-Phase Inverters for Small Distributed Power Generators: An Overview (2004)

This paper presents an overview of single-phase inverters developed for small distributed power generators. The functions of inverters in distributed power generation (DG) systems include dc-ac conversion, output power quality assurance, various protection mechanisms, and system controls. Unique requirements for small distributed power generation systems include low cost, high efficiency and tolerance for an extremely wide range of input voltage variations. These requirements have driven the inverter development toward simpler topologies and structures, lower component counts, and tighter modular design. Both single-stage and multiple-stage inverters have been developed for power conversion in DG systems. Single-stage inverters offer simple structure and low cost, but suffer from a limited range of input voltage variations and are often characterized by compromised system performance. On the other hand, multiple-stage inverters accept a wide range of input voltage variations, but suffer from high cost, complicated structure and low efficiency. Various circuit topologies are presented, compared, and evaluated against the requirements of power decoupling and dual-grounding, the capabilities for grid-connected or/and stand-alone operations, and specific DG applications in this paper, along with the identification of recent development trends of single-phase inverters for distributed power generators.
Application of siRNA Against SARS in the Rhesus Macaque Model (2008)

Containment of the SARS coronavirus (SCV) outbreak was accompanied by the rapid characterization of this new pathogen's genome sequence in 2003, encouraging the development of anti-SCV therapeutics using short interfering RNA (siRNA) inhibitors. A pair of siRNA duplexes identified as potent SCV inhibitors in vitro was evaluated for in vivo efficacy and safety in a rhesus macaque SARS model using intranasal administration with clinical viable delivery carrier in three dosing regimens. Observations of SCV-induced SARS-like symptoms, measurements of SCV RNA presence in the respiratory tract, microscopic inspections of lung histopathology, and immunohistochemistry sections from 21 tested macaques consistently demonstrated siRNA-mediated anti-SCV activity. The prophylactic and therapeutic efficacies resulted in relief of animals from SCV infection-induced fever, diminished SCV in upper airway and lung alveoli, and milder acute diffuse alveoli damage (DAD). The dosages of siRNA used, 10 to 40 mg/kg, did not show any sign of siRNA-induced toxicity. These results support that a clinical investigation of this anti-SARS siRNA therapeutic agent is warranted. The study also illustrates the capability of siRNA to enable a massive reduction in development time for novel targeted therapeutic agents. We detail a representative example of large-mammal siRNA use.
Propene Polymerization with Stereospecific Metallocene Dichloride−[Ph3C][B(C6F5)4] Using ω-Alkenylaluminum as an Alkylation Reagent and as a Functional Comonomer (2002)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTPropene Polymerization with Stereospecific Metallocene Dichloride−[Ph3C][B(C6F5)4] Using ω-Alkenylaluminum as an Alkylation Reagent and as a Functional ComonomerYoung-Gon Nam, Takeshi Shiono, and Tomiki IkedaView Author Information Tokyo Institute of Technology, Chemical Resources Laboratory, 4259 Nagatuda, Midori-ku, Yokohama 226-8503, Japan Cite this: Macromolecules 2002, 35, 18, 6760–6762Publication Date (Web):July 24, 2002Publication History Received1 April 2002Revised2 July 2002Published online24 July 2002Published inissue 1 August 2002https://pubs.acs.org/doi/10.1021/ma025528yhttps://doi.org/10.1021/ma025528yrapid-communicationACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views931Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alkyls,Catalysts,Polymerization,Polymers,Sandwich compounds Get e-Alerts
ChemInform Abstract: A STEREOSELECTIVE SYNTHESIS OF D‐ERYTHRO‐SPHINGOSINE (1973)

Abstract Die Synthese der Titelverbindung (V) erfolgt ausgehend von L‐Serin (Ia) über die Derivate (Ib) und (Ic); letzteres wird zum Aldehyd (II) hydriert, dessen Umsetzung mit dem Alan (III) das D‐erythro‐Sphingosin‐Derivat (IV) liefert (zusammen mit dem in der Natur nicht vorkommenden threo‐Isomeren).