gebhart/patrepeval huggingface dataset:
Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer (2004)

The Benzopyrones are a group of compounds whose members include coumarins and flavonoids. Dietary exposure to benzopyrones is quite significant, as these compounds are found in vegetables, fruit, seeds, nuts, coffee, tea and wine. It is estimated that the average western diet contains approximately 1 g/day of mixed benzopyrones. It is, therefore, not difficult to see why extensive research into their pharmacological and therapeutic properties is underway over many years. Coumarin is a natural substance that has shown anti-tumour activity in vivo, with the effect believed to be due to its metabolites (e.g. 7-hydroxycoumarin). This review is based on recent studies of coumarins and coumarin related compounds. Therefore, the focus will be on these relevant compounds and their therapeutic importance. A recent study has shown that 7-hydroxycoumarin inhibits the release of Cyclin D1, which is overexpressed in many types of cancer. This knowledge may lead to its use in cancer therapy. Esculetin inhibits growth and cell cycle progression by inducing arrest of the G(1) phase in HL-60 leukaemia cells, resulting from the inhibition of retinoblastoma protein phosphorylation. Recent studies investigating the potential of flavonoids as therapeutic agents have suggested they may have use in various therapeutic settings ranging from leukaemia treatment to the treatment of patients with HIV. Genistein is a well-known isoflavone and is a tyrosine kinase inhibitor. Studies have indicated that genistein elicits inhibitory effects on cell growth of various carcinoma cell-lines and may be a potential candidate for cancer therapy. In our research, we have investigated the effects of coumarins and coumarin-related compounds on a panel of cell-lines. The most recent work involves two cell-lines, MCF-7 a breast carcinoma and A549 a lung carcinoma. Microtitre assays were performed along with real-time analysis of cell viability using a biosensor called the Cytosensor microphysiometer. These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds.
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury (2010)

Acetaminophen (APAP) hepatotoxicity is the main cause of acute liver failure in humans. Although mitochondrial oxidant stress and induction of the mitochondrial permeability transition (MPT) have been implicated in APAP-induced hepatotoxicity, the link between these events is unclear. To investigate this, this study evaluated APAP hepatotoxicity in mice deficient of cyclophilin D, a protein component of the MPT. Treatment of wild type mice with APAP resulted in focal centrilobular necrosis, nuclear DNA fragmentation and formation of reactive oxygen (elevated glutathione disulphide levels) and peroxynitrite (nitrotyrosine immunostaining) in the liver. CypD-deficient (Ppif(-/-)) mice were completely protected against APAP-induced liver injury and DNA fragmentation. Oxidant stress and peroxynitrite formation were blunted but not eliminated in CypD-deficient mice. Thus, mitochondrial oxidative stress and induction of the MPT are critical events in APAP hepatotoxicity in vivo and at least part of the APAP-induced oxidant stress and peroxynitrite formation occurs downstream of the MPT.
Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange (2007)

Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain (half-molecule) with a heavy-light chain pair from another molecule, which results in bispecific antibodies. Mutagenesis studies revealed that the third constant domain is critical for this activity. The impact of IgG4 Fab arm exchange was confirmed in vivo in a rhesus monkey model with experimental autoimmune myasthenia gravis. IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.
Preparation and reactions of 2,6-di-tert-butyl-4-(9-fluorenylidene)-1,4-benzoquinone (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of 2,6-di-tert-butyl-4-(9-fluorenylidene)-1,4-benzoquinoneHans Dieter Becker and Kenneth GustafssonCite this: J. Org. Chem. 1976, 41, 2, 214–221Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/jo00864a007https://doi.org/10.1021/jo00864a007research-articleACS PublicationsRequest reuse permissionsArticle Views670Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen. (1989)

SS-A/Ro is a nucleocytoplasmic ribonucleoprotein (RNP) particle that is a common target of autoimmune response in Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). Previously, SS-A/Ro has been shown to be composed of at least two polypeptide antigens of 60 and 52 kD noncovalently associated with a set of small RNAs, designated Y1-Y5. A serum from an SS patient was selected to screen a lambda gt11 cDNA library constructed from human T cell lymphoblastic leukemia (MOLT-4) mRNA. An immunoreactive clone was isolated that possessed a 1.8-kb cDNA insert. In vitro transcription and translation of the cDNA resulted in the synthesis of a 57.5-kD polypeptide which was specifically immunoprecipitated by SS-A/Ro antisera. The identity of the cDNA encoded protein as the 60-kD SS-A/Ro antigen was established by proteolytic peptide mapping of the cDNA-encoded protein and the 60-kD HeLa cell antigen. The sequence of the cDNA shows that the 60-kD SS-A/Ro protein possesses both RNA binding protein consensus sequences and a single zinc-finger motif. Recombinant SS-A/Ro antigen produced in bacteria proved to be a sensitive and specific reagent for detection of anti-SS-A/Ro antibodies in patient sera. The availability of the 60-kD SS-A/Ro cDNA will enable detailed analysis of the molecular structure and function of the SS-A/Ro RNP particle and its role in autoimmune pathology.
A Wearable Wireless Reflectance Pulse Oximeter for Remote Triage Applications (2006)

To save life, casualty care requires that trauma injuries are accurately and expeditiously assessed in the field. Thus, it is important that victims will be rapidly stabilized and vital signs continuously monitored to detect potential life threatening conditions that may require critical life saving measures. This paper describes the initial bench testing of a wearable wireless pulse oximeter system, which includes a forehead mounted optical sensor, and compares its performance with that of a Masimo SET pulse oximeter.
Biocompatible Graphene Oxide-Based Glucose Biosensors (2010)

This letter demonstrates that a novel, highly efficient enzyme electrode can be directly obtained using covalent attachment between carboxyl acid groups of graphene oxide sheets and amines of glucose oxidase. The resulting biosensor exhibits a broad linear range up to 28 mM x mm(-2) glucose with a sensitivity of 8.045 mA x cm(-2) x M(-1). The glucose oxidase-immobilized graphene oxide electrode also shows a reproducibility and a good storage stability, suggesting potentials for a wide range of practical applications. The biocompatibility of as-synthesized graphene oxide nanosheets with human cells, especially retinal pigment epithelium (RPE) cells, was investigated for the first time in the present work. Microporous graphene oxide exhibits good biocompatibility and has potential advantages with respect to cell attachment and proliferation, leading to opportunities for using graphene-based biosensors for the clinical diagnosis.
Identification and characterization of high affinity antisense PNAs for the human unr (upstream of N-ras) mRNA which is uniquely overexpressed in MCF-7 breast cancer cells (2005)

We have recently shown that an MCF-7 tumor can be imaged in a mouse by PET with 64Cu-labeled Peptide nucleic acids (PNAs) tethered to the permeation peptide Lys4 that recognize the uniquely overexpressed and very abundant upstream of N-ras or N-ras related gene (unr mRNA) expressed in these cells. Herein we describe how the high affinity antisense PNAs to the unr mRNA were identified and characterized. First, antisense binding sites on the unr mRNA were mapped by an reverse transcriptase random oligonucleotide library (RT-ROL) method that we have improved, and by a serial analysis of antisense binding sites (SAABS) method that we have developed which is similar to another recently described method. The relative binding affinities of oligodeoxynucleotides (ODNs) complementary to the antisense binding sites were then qualitatively ranked by a new Dynabead-based dot blot assay. Dissociation constants for a subset of the ODNs were determined by a new Dynabead-based solution assay and were found to be 300 pM for the best binders in 1 M salt. PNAs corresponding to the ODNs with the highest affinities were synthesized with an N-terminal CysTyr and C-terminal Lys4 sequence. Dissociation constants of these hybrid PNAs were determined by the Dynabead-based solution assay to be about 10 pM for the highest affinity binders.
A discrete multitone transceiver system for HDSL applications (1991)

A discrete multitone (DMT) transceiver design for high bit rate digital subscriber line (HDSL) access is presented and analyzed. The DMT transmitter and receiver structure and algorithms are detailed, and the computational requirements of DMT for HDSL are estimated. At a sampling rate of 640 kHz, using an appropriate combination of a short finite-impulse-response (FIR) equalizer and a length-512 DMT system, 1.6 Mb/s data transmission is possible within the carrier serving area (CSA) at an error rate of 10/sup -7/ on a single twisted pair. A significant performance margin can be achieved when two coordinated twisted pairs are used to deliver a total data rate of 1.6 Mb/s. In terms of a performance-per-computation figure of merit, the DMT system is an excellent candidate for HDSL implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunity Induced By Primary Human Cytomegalovirus Infection Protects Against Secondary Infection Among Women Of Childbearing Age (1995)

To determine if immunity to human cytomegalovirus (HCMV) protects women from acquiring HCMV from their children, a blinded, randomized protocol was used to monitor seronegative women who received placebo or Towne vaccine (approximately 500 pfu) and seropositive women. Each group was similar for mean maternal (33 years) and child age (18 months) and duration of viral shedding by the child (15 months). Among 19 placebo recipients, 9 developed primary infection; 8 of 19 vaccines but only 3 of 42 naturally seropositive subjects had evidence of acquiring HCMV from their child. Wild type infection and Towne vaccine induced similar mean lymphoproliferative responses to HCMV antigens, but one dose of Towne vaccine produced mean neutralizing titers 10- to 20-fold lower than those after wild type infection. Thus, a vaccine that induces immune responses equal to those induced by wild type virus may protect healthy women from acquiring HCMV from their children.
Non-symmetrical diarylcarboxylic acids via rhodium(i)-catalyzed regiospecific cross-dehydrogenation coupling of aromatic acids: twofold direct C–H bond activations in water (2016)

An efficient, regiospecific, and general cross-dehydrogenative coupling reaction of free aryl acids to generate non-symmetrical diaryl acids was developed. This strategy involves a two fold direct C–H activation catalyzed by rhodium in water, and can be easily scaled up.
Improving dialogue classification using a topic space representation and a Gaussian classifier based on the decision rule (2014)

In this paper, we study the impact of dialogue representations and classification methods in the task of theme identification of telephone conversation services having highly imperfect automatic transcriptions. Two dialogue representations are firstly compared: the classical Term Frequency-Inverse Document Frequency with Gini purity criteria (TF-IDF-Gini) method and the Latent Dirichlet Allocation (LDA) approach. We then propose to study an original classification method that takes advantage of the LDA topic space representation, highlighted as the best dialogue representation. To do so, two assumptions about topic representation led us to choose a Gaussian process (GP) based method. This approach is compared with a Support Vector Machine (SVM) classification method. Results show that the GP approach is a better solution to deal with the multiple theme complexity of a dialogue, no matter the conditions studied (manual or automatic transcriptions). We finally discuss the impact of the topic space reduction on the classification accuracy.
Agronomic and Seed Characteristics of Soybean Lines with Increased Oleate Content (2008)

Soybean [ Glycine max (L.) Merr.] lines have been developed with the ol allele for elevated oleate from the mutant line M23 and alleles for reduced linolenate as a means of increasing stability of the oil. The purpose of this study was to evaluate the influence of elevated oleate content on agronomic and seed traits. From each of three segregating populations, 27 low‐linolenate lines with a mean oleate content &gt;500 g kg −1 and 27 low‐linolenate lines with a mean oleate content &lt;280 g kg −1 were selected for evaluation in three Iowa environments in 2007. The mean seed yield of the mid‐oleate (MO) lines was significantly less by 12% than the lines with conventional oleate (CO) content and the highest yielding lines in each population were of the CO type. The mean protein content of the MO lines was significantly greater by 14 g kg −1 and their mean oil content significantly less by 7 g kg −1 than the CO lines. The mean differences between the MO and CO lines were &lt;1 d for time of maturity, 3 cm for plant height, 0.3 for lodging score, and 8 mg seed −1 for seed weight. The primary challenge for developing commercially acceptable MO lines derived from M23 will be to overcome the difference in yield compared with CO lines.
Sucralfate--alternative therapy for peptic-ulcer disease. (1983)

The pharmacology, pharmacokinetics, clinical studies, adverse reactions, and dosage of sucralfate (Carafate, Marion Laboratories), a unique drug for peptic-ulcer disease, are reviewed. Sucralfate exerts its antiulcer effect by binding with proteinacious material, neutralizing local acidity without affecting gastric pH, and forming a protective barrier at the ulcer site. It also inhibits the diffusion of hydrogen ion, inhibits the action of pepsin, and adsorbs bile salts. Approximately 3-5% of an orally administered dose of sucralfate is absorbed; more than 90% of the dose is excreted unchanged in the feces. Sucralfate remains at the site of gastric ulcers for up to six hours. In the treatment of duodenal ulcers, sucralfate is more effective than placebo and comparable with cimetidine and intensive antacid therapy. Healing rates for gastric ulcers are less impressive but are comparable with those produced by cimetidine and antacids. Additive or synergistic effects of sucralfate with cimetidine or intensive antacid therapy have not been studied. Sucralfate has few side effects because it is not absorbed; most frequently reported are constipation (3-4%), xerostomia (1%), and skin eruptions (0.6%). No drug-drug interactions have been reported. The recommended dose of sucralfate is 1 g four times a day one hour before meals and at bedtime. Sucralfate is a unique antiulcer drug that compares favorably with cimetidine and antacid therapy in terms of safety and efficacy. Sucralfate is FDA-approved for short-term (up to eight weeks) treatment of duodenal ulcers.
Towards Requirements for IP Routers (1994)

The goal of this work is to replace RFC-1009, Requirements for
Internet Gateways ([INTRO:1]) with a new document. It defines and
discusses requirements for devices which perform the network layer
forwarding function of the Internet protocol suite. This memo provides
information for the Internet community. This memo does not specify an
Internet standard of any kind.
Supplementing Rations with Tocopherol and Ethoxyquin to Increase Oxidative Stability of Milk (1967)

A Latin-square change-over feeding trial was conducted to study the feasibility of supplementing cow rations with antioxidants to aid in practical control of oxidized flavor in milk. Ethoxyquin supplement, at 0.01.25% of the dIT matter intakei caused a slight increase in milk toeopherol (P < 0.1) and in oxidative stability of the milk (P < 0.05) as measured by the TBA test. Determinations of ethoxyquin by a fluorimetric method indicated that ethoxyquin was present in the milk of three cows that were fed the antioxidant for seven days at. 0.015% of dry matter intake. Supplementary dl-a-tocopheryl acetate, fed at 0.0025% of tocopherol in the dry matter, increased the concentration of toeopherol in the milk (P < 0.01), the oxidative stability of the nfilk (P < 0.01) by both TBA test and flavor scores) and of' the milk fat (P < 0.01 by induction period test). Supplementing cows' rations with tocopherol is feasible as a practical method of delaying the development of oxidized flavor in milk.
A single nucleotide polymorphism of the TNRC9 gene associated with breast cancer risk in Chinese Han women (2014)

A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, including 388 breast cancer patients and 482 healthy controls, via the PCR-single strand conformation polymorphism procedure and by sequence detection. We found that the T allele and the TT genotype of the SNP rs38033662 is significantly associated with risk for breast cancer in Chinese Han women; however, no significant association was found for rs1362548 or rs1123428. We conclude that SNP rs3803662 is a putative risk factor for breast cancer in Chinese Han women.
Burkholderia phytofirmans sp. nov., a novel plant-associated bacterium with plant-beneficial properties (2005)

A Gram-negative, non-sporulating, rod-shaped, motile bacterium, with a single polar flagellum, designated strain PsJN(T), was isolated from surface-sterilized onion roots. This isolate proved to be a highly effective plant-beneficial bacterium, and was able to establish rhizosphere and endophytic populations associated with various plants. Seven related strains were recovered from Dutch soils. Based on 16S rRNA gene sequence data, strain PsJN(T) and the Dutch strains were identified as representing a member of the genus Burkholderia, as they were closely related to Burkholderia fungorum (98.7 %) and Burkholderia phenazinium (98.5 %). Analysis of whole-cell protein profiles and DNA-DNA hybridization experiments confirmed that all eight strains belonged to a single species. Strain PsJN(T) had a DNA G+C content of 61.0 mol%. Only low levels of DNA-DNA hybridization to closely related species were found. Qualitative and quantitative differences in fatty acid composition between strain PsJN(T) and closely related species were identified. The predominant fatty acids in strain PsJN(T) were 16 : 0, 18 : 1omega7c and summed feature 3 (comprising 16 : 1omega7c and/or iso-15 : 0 2-OH). Isolate PsJN(T) showed high 1-aminocyclopropane-1-carboxylate deaminase activity and is therefore able to lower the ethylene level in a developing or stressed plant. Production of the quorum-sensing signal compound 3-hydroxy-C8-homoserine lactone was detected. Based on the results of this polyphasic taxonomic study, strain PsJN(T) and the seven Dutch isolates are considered to represent a single, novel species, for which the name Burkholderia phytofirmans sp. nov. is proposed. The type strain is strain PsJN(T) (=LMG 22146(T) = CCUG 49060(T)).
Low insertion loss and high linearity PHEMT SPDT and SP3T switch ICs for WLAN 802.11 a/b/g applications (2004)

GaAs SPDT and SP3T antenna switch ICs for IEEE 802.11 a/b/g applications are developed. By using advanced Skyworks PHEMT technologies, it is possible to achieve an insertion loss as low as 0.55 dB for SPDT switch, 0.5 dB lower than any previously reported DC-6 GHz band switch, and high linearity with 55 dBm input IP3 and a high isolation over 20 dB at 3 V; the SP3T switch also exhibits excellent performance with an insertion loss of 0.9 dB, input IP3 of 47 dBm and isolation over 25 dB throughout DC-6 GHz band. The high performance comes from the following technologies: series and shunt topology with dual-gate FETs, AlGaAs/InGaAs/AlGaAs 0.5 /spl mu/m EPI-based process with a fully selective dual recess etch, and the relatively shallow pinch off voltage of -0.5 V (Y. Tkachenko et al., Euro. Microwave Conf. Dig., pp. 1041-1045, 1997).
随心而行--降压有方，乐施小善 (2011)

我们距离2012年又近了一步--“2012”这四个数字是否让你浑身打颤，毛骨悚然又神经紧绷？如果是，那你在2011年这一年就得好好调节情绪，降降压咯，从学生的“减负”到如今全民“减压”，如何调整身心状态，以便更好地面对逐渐加快的社会节奏和日趋沉重的各种责任，