gebhart/patrepeval huggingface dataset:
Blind Source Separation Using Temporal Predictability (2001)

A measure of temporal predictability is defined and used to separate linear mixtures of signals. Given any set of statistically independent source signals, it is conjectured here that a linear mixture of those signals has the following property: the temporal predictability of any signal mixture is less than (or equal to) that of any of its component source signals. It is shown that this property can be used to recover source signals from a set of linear mixtures of those signals by finding an un-mixing matrix that maximizes a measure of temporal predictability for each recovered signal. This matrix is obtained as the solution to a generalized eigenvalue problem; such problems have scaling characteristics of O(N3), where N is the number of signal mixtures. In contrast to independent component analysis, the temporal predictability method requires minimal assumptions regarding the probability density functions of source signals. It is demonstrated that the method can separate signal mixtures in which each mixture is a linear combination of source signals with supergaussian, subgaussian, and gaussian probability density functions and on mixtures of voices and music.
Collision Detection and Reaction: A Contribution to Safe Physical Human-Robot Interaction (2008)

In the framework of physical Human-Robot Interaction (pHRI), methodologies and experimental tests are presented for the problem of detecting and reacting to collisions between a robot manipulator and a human being. Using a lightweight robot that was especially designed for interactive and cooperative tasks, we show how reactive control strategies can significantly contribute to ensuring safety to the human during physical interaction. Several collision tests were carried out, illustrating the feasibility and effectiveness of the proposed approach. While a subjective “safety” feeling is experienced by users when being able to naturally stop the robot in autonomous motion, a quantitative analysis of different reaction strategies was lacking. In order to compare these strategies on an objective basis, a mechanical verification platform has been built. The proposed collision detection and reactions methods prove to work very reliably and are effective in reducing contact forces far below any level which is dangerous to humans. Evaluations of impacts between robot and human arm or chest up to a maximum robot velocity of 2.7 m/s are presented.
The TF:VIIa Complex: Clinical Significance, Structure-function Relationships and Its Role in Signaling and Metastasis (2001)

Summary In healthy humans, blood vessel-tissue factor is found primarily in the adventitia and thus physically separated from coagulation factors, which mainly circulate in an inactive form. Following injury, TF is exposed to blood and initiates the coagulation cascade. The resulting fibrin formation is an essential part for the initial repair of vessel damage to minimize blood-loss (reviewed by (1-4). Therefore, TF may be considered to form a hemostatic sheath around blood vessels essential for hemostasis and appears to be essential for life inasmuch as no TF deficiency has been reported and TF knockout mice do not survive beyond the perinatal period.
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex (1997)

During neuronal migration to the developing cerebral cortex, neurons regulate radial glial cell function and radial glial cells, in turn, support neuronal cell migration and differentiation. To study how migrating neurons and radial glial cells influence each others' function in the developing cerebral cortex, we examined the role of glial growth factor (a soluble form of neuregulin), in neuron-radial glial interactions. Here, we show that GGF is expressed by migrating cortical neurons and promotes their migration along radial glial fibers. Concurrently, GGF also promotes the maintenance and elongation of radial glial cells, which are essential for guiding neuronal migration to the cortex. In the absence of GGF signaling via erbB2 receptors, radial glial development is abnormal. Furthermore, GGF's regulation of radial glial development is mediated in part by brain lipid-binding protein (BLBP), a neuronally induced, radial glial molecule, previously shown to be essential for the establishment and maintenance of radial glial fiber system. The ability of GGF to influence both neuronal migration and radial glial development in a mutually dependent manner suggests that it functions as a mediator of interactions between migrating neurons and radial glial cells in the developing cerebral cortex.
Synthesis and GC-MS Analysis of Alkylthiophenes. (1993)

C2～C4アルキルチオフェン類には49種類の化合物が存在するが,市販の試薬として一般に入手可能なのはその中の6種類程度であるので,残りの化合物のうちの36種類の化合物と20種類のC5-アルキルチオフェン類を合成した。ジメチル-,トリメチル-およびテトラメチルチオフェン類は,シリカーアルミナ触媒上でテトラメチルベンゼンからメチルチオフェンヘメチル基を移行させることにより合成した。他の化合物は塩化アルミニウム触媒上で,市販のチオフェン類と臭化アルキルを反応させることにより合成した。たとえば,エチルメチルチオフェソ類はメチルチオフェンと臭化エチルおよびエチルチオフェソとヨウ化メチルの反応で合成され,合成経路および合成された化合物に関する沸点データの報告値から異性体の構造を決定した.合成されたチオフェン類の混合物について,分子量ごとにGC-MSを用いてイオンクロマトグラムを測定し,多くの異性体について保持時間のインデックスを作成した。
Notes - Catalytic Reduction of 2-Acylthiophenes (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Catalytic Reduction of 2-AcylthiophenesPrice Truitt, E. Holst, and George SammonsCite this: J. Org. Chem. 1957, 22, 9, 1107–1109Publication Date (Print):September 1, 1957Publication History Published online23 April 2003Published inissue 1 September 1957https://pubs.acs.org/doi/10.1021/jo01360a603https://doi.org/10.1021/jo01360a603research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes (1988)

Lipid vesicles with a positive surface charge have been prepared by using mixtures of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) together with low mole fractions of a cationic lipid analogue, 1,2-bis(oleoyloxy)-3-(trimethylammonio)propane (DOTAP). We have used measurements of vesicle aggregation, lipid mixing, contents mixing, and contents leakage to examine the interactions between these vesicles and similar vesicles that carry a negative surface charge. Mixtures of vesicles with opposite surface charges aggregate readily at physiological or lower ionic strengths, and the extent of this aggregation is enhanced for vesicles that contain high proportions of PE relative to PC. Mixing of lipids and aqueous contents can also be observed between such vesicles, particularly when the vesicles contain substantial proportions of PE. Surprisingly, these latter processes are strongly promoted by monovalent salts and do not proceed at very low ionic strengths. PE/DOTAP vesicles show substantial lipid mixing with negatively charged vesicles containing high proportions of phosphatidylcholine, as well as with human erythrocyte ghosts, on a time scale of a few minutes. These interactions are strongly promoted both by the presence of high levels of PE in the cationic vesicles and by the presence of complementary surface charges on the two membrane populations.
Characterization of EuS Nanotubes in Quantum Confinement (2009)

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009
Massively parallel fabrication of repetitive nanostructures: nanolithography for nanoarrays (2009)

This topical review provides an overview of nanolithographic techniques for nanoarrays. Using patterning techniques such as lithography, normally we aim for a higher order architecture similarly to functional systems in nature. Inspired by the wealth of complexity in nature, these architectures are translated into technical devices, for example, found in integrated circuitry or other systems in which structural elements work as discrete building blocks in microdevices. Ordered artificial nanostructures (arrays of pillars, holes and wires) have shown particular properties and bring about the opportunity to modify and tune the device operation. Moreover, these nanostructures deliver new applications, for example, the nanoscale control of spin direction within a nanomagnet. Subsequently, we can look for applications where this unique property of the smallest manufactured element is repetitively used such as, for example with respect to spin, in nanopatterned magnetic media for data storage. These nanostructures are generally called nanoarrays. Most of these applications require massively parallel produced nanopatterns which can be directly realized by laser interference (areas up to 4 cm2 are easily achieved with a Lloyd's mirror set-up). In this topical review we will further highlight the application of laser interference as a tool for nanofabrication, its limitations and ultimate advantages towards a variety of devices including nanostructuring for photonic crystal devices, high resolution patterned media and surface modifications of medical implants. The unique properties of nanostructured surfaces have also found applications in biomedical nanoarrays used either for diagnostic or functional assays including catalytic reactions on chip. Bio-inspired templated nanoarrays will be presented in perspective to other massively parallel nanolithography techniques currently discussed in the scientific literature. © 2009 IOP Publishing Ltd.
Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats (1990)

Hypothalamic neuropeptides play a role in appetite and weight regulation. Food restriction for 2 weeks and food deprivation for 4 days were used as models to characterize the effects of weight loss on hypothalamic peptide gene expression in male and female rats. We used in situ hybridization to examine the mRNA levels of hypothalamic peptides which stimulate and inhibit food intake and found selective effects primarily in the arcuate nucleus. Neuropeptide Y (NPY) mRNA was increased and pro-opiomelanocortin (POMC) and galanin (GAL) mRNA were decreased in the hypothalamic arcuate nucleus and corticotropin-releasing hormone (CRH) mRNA was decreased in the hypothalamic paraventricular nucleus in male and female food-restricted and food-deprived rats. Food restriction produced larger changes in peptide mRNA expression than did food deprivation. Changes in NPY, POMC and CRH gene expression induced by food restriction were greater in male than female rats. Elevated NPY and reduced CRH gene expression may be a compensatory physiological response to restore food intake in food-restricted and food-deprived animals. The discrete changes in NPY, POMC, GAL and CRH gene expression in food-restricted and food-deprived animals suggest the involvement of these peptides in abnormal appetitive behavior and weight loss associated with human eating disorders.
Early temporal‐specific responses and differential sensitivity to lithium and Wnt‐3A exposure during heart development (2006)

Members of both Wnt and bone morphogenetic protein (BMP) families of signaling molecules are important in heart development. We previously demonstrated that beta-catenin, a key downstream intermediary of the canonical Wnt signaling pathway, delineates the dorsal boundary of the cardiac compartments in an anteroposterior progression. We hypothesized the progression involves canonical Wnt signaling and reflects development of the primary body axis of the embryo. A similar anteroposterior signaling wave leading to cardiac cell specification involves inductive signaling by BMP-2 synthesized by the underlying endoderm in anterior bilateral regions. Any molecule that disrupts the normal balance of Wnt and BMP concentrations within the heart field may be expected to affect early heart development. The canonical Wnt signaling step mimicked by lithium involves inactivation of glycogen synthase kinase-3beta (GSK-3beta; Klein and Melton [1996] Proc. Natl. Acad. Sci. U. S. A. 93:8455-8459). We show that lithium, Wnt-3A, and an inhibitor of GSK-3beta, SB415286, affect early heart development at the cardiac specification stages. We demonstrate that normal expression patterns of key signaling molecules as Notch-1 and Dkk-1 are altered in the anterior mesoderm within the heart fields by a one-time exposure to lithium, or by noggin inhibition of BMP, at Hamburger and Hamilton (HH) stage 3 during chick embryonic development. The severity of developmental defects is greatest with exposure to lithium or Wnt-3A at HH stage 3 and decreases at HH stage 4. Taken together, our results demonstrate that there are temporal-specific responses and differential sensitivities to lithium/Wnt-3A exposure during early heart development.
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. (1988)

The antiviral antibiotic brefeldin A (BFA) strongly inhibits the protein secretion in cultured rat hepatocytes (Misumi, Y., Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., and Ikehara, Y. (1986) J. Biol. Chem. 261, 11398-11403). We have further examined the inhibitory effect of the drug on intracellular transport of albumin by an immunocytochemical technique with peroxidase-conjugated Fab fragments of anti-rat albumin IgG. In hepatocytes treated with BFA (2.5 micrograms/ml) for 1 h at 37 degrees C, no characteristic structures of the Golgi complex could be observed, and albumin was diffusely distributed in the endoplasmic reticulum (ER), nuclear envelope, and small vesicles around, in contrast to its condensed localization in the Golgi complex in the control cells. Such an unusual distribution of the secretory protein, however, was rearranged to the normal localization in the Golgi complex after 4 h even in the presence of the drug, possibly due to a metabolism of the drug to an inert form. Exposure of the cells to BFA with constant renewals (2.5 micrograms/ml at 1-h intervals) or at a higher concentration (10 micrograms/ml) caused a prolonged accumulation of albumin in the ER, resulting in its dilation. These results indicate that BFA primarily blocks the protein transport from the ER to the Golgi complex, consistent with the biochemical data previously reported.
Thienamycin total synthesis. 1. Synthesis of azetidinone precursors of (.+-.)-thienamycin and its stereoisomers (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThienamycin total synthesis. 1. Synthesis of azetidinone precursors of (.+-.)-thienamycin and its stereoisomersF. Aileen Bouffard, David B. R. Johnston, and Burton G. ChristensenCite this: J. Org. Chem. 1980, 45, 6, 1130–1135Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/jo01294a042https://doi.org/10.1021/jo01294a042research-articleACS PublicationsRequest reuse permissionsArticle Views378Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Serotyping of Adenoviruses on Conjunctival Scrapings by PCR and Sequence Analysis (1999)

To detect and identify adenovirus (Ad), we investigated hypervariable regions (HVRs) of Ad by using a combination of PCR and direct sequencing (PCR-sequence) method. Primers for nested PCR to amplify the conserved region in the hexon protein containing HVRs were designed based on hexon gene sequences derived from GenBank. These two primer sets amplified a DNA fragment of 7 HVRs from 16 prototypes of Ad, which were divided into five subgenera, including seven serotypes that are the predominant causative agents of acute conjunctivitis in Japan, and from 31 recent conjunctival scraping specimens from patients with adenoviral conjunctivitis. HVR DNA sequences were determined by means of universal sequence primers. Analysis of the predicted amino acid homology of HVRs among Ad prototypes suggested three regions, HVR4, -5, and -7, to be candidates for the neutralization epitopes. The clinical serotype of specimens was determined by the PCR-sequence method with reference to these three HVRs. The serotype determined according to this method was identical to that obtained by culture isolation and the neutralization test (NT) in all scraping samples, whereas the results of this method did not match PCR and restriction fragment length polymorphism (PCR-RFLP) analysis in five samples. It took only three days to detect Ad and to identify the serotype, in contrast to culture isolation-NT, which took at least 2 weeks. These findings indicate that our newly developed PCR-sequence method is applicable for the detection and serotyping of human Ads.
Sorting of differentiated neurons using Phototransistor-based optoelectronic tweezers for cell replacement therapy of neurodegenerative diseases (2009)

A major challenge in cell replacement therapy for neurological diseases is the sorting of differentiated neurons because conventional cell sorting techniques require cells in suspension. Recently, spherical glass beads have been demonstrated as a movable growth substrate, allowing transport of differentiated neurons without dissociation. Phototransistor-based optoelectronic tweezers provides a gentle mean to optically manipulate cells. By combining these two approaches, we demonstrated fluorescent-activated automatic sorting of differentiated neurons. We envision employing this cell sorting system for cell replacement therapy to treat neurodegenerative diseases and other nerve injuries.
Preparation and Characterization of Antibodies to the Urinary Fragment of the Human Chorionic Gonadotropin β-Subunit* (1988)

hCG is a glycoprotein hormone composed of two dissimilar subunits (alpha and beta) and is normally synthesized by trophoblastic tissue. Its measurement by immunoassay is widely employed as a test for pregnancy, but can be complicated by cross-reactivity with human (h) LH. Immunoassays based on the beta-subunit of hCG have been employed to decrease this cross-reactivity with hLH, but when these assays are used with urine specimens, the antibodies employed also detect a fragment of hCG beta, which can lead to significant differences in measurement. To overcome these problems, we have developed a series of monoclonal antibodies to the beta fragment of hCG recovered from pregnancy urine. Some of the antibodies that bind to this beta fragment are directed to a region of hCG beta that is different from the epitopes recognized by antibodies raised against the intact beta-subunit. The new epitopes available in the hCG beta fragment form the basis for novel immunoassays. These beta fragment antibodies are used in conjunction with other antibodies, directed to different epitopes of the hormone, to produce a series of immunoradiometric assays that can discriminate among intact hormone, free hCG beta, and hCG beta fragment. The hCG beta fragment antibodies described herein have affinities between 10(9) and 10(11) M-1 for the beta fragment and exhibit varying degrees of discrimination between the hCG beta fragment, the beta-subunits of hCG and hLH, and intact hCG and hLH.
Photonic Integration on the Hybrid Silicon Evanescent Device Platform (2008)

This paper reviews the recent progress of hybrid silicon evanescent devices. The hybrid silicon evanescent device structure consists of III‐V epitaxial layers transferred to silicon waveguides through a low‐temperature wafer bonding process to achieve optical gain, absorption, and modulation efficiently on a silicon photonics platform. The low‐temperature wafer bonding process enables fusion of two different material systems without degradation of material quality and is scalable to wafer‐level bonding. Lasers, amplifiers, photodetectors, and modulators have been demonstrated with this hybrid structure and integration of these individual components for improved optical functionality is also presented. This approach provides a unique way to build photonic active devices on silicon and should allow application of silicon photonic integrated circuits to optical telecommunication and optical interconnects.
External iodine atoms influence over the intersystem crossing rate of cyanine iodide ion pair in benzene solution (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExternal iodine atoms influence over the intersystem crossing rate of cyanine iodide ion pair in benzene solutionBjorn Sauerwein and Gary B. SchusterCite this: J. Phys. Chem. 1991, 95, 5, 1903–1906Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/j100158a006https://doi.org/10.1021/j100158a006research-articleACS PublicationsRequest reuse permissionsArticle Views299Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts