gebhart/patrepeval huggingface dataset:
trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis:  Applications in Asymmetric Synthesis and Molecular Recognition (1997)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTtrans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis: Applications in Asymmetric Synthesis and Molecular RecognitionYoussef L. Bennani and Stephen HanessianView Author Information Abbott Laboratories, 100 Abbott Park, AP10, Abbott Park, Illinois 60064-3500, and Department of Chemistry, Université de Montréal, B.P. 6128, Succursale Centre-Ville, Montreal, Quebec, H3C 3J7, Canada Cite this: Chem. Rev. 1997, 97, 8, 3161–3196Publication Date (Web):December 18, 1997Publication History Received18 March 1997Revised1 August 1997Published online18 December 1997Published inissue 1 December 1997https://pubs.acs.org/doi/10.1021/cr9407577https://doi.org/10.1021/cr9407577research-articleACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views5597Altmetric-Citations366LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Hydrocarbons,Ligands,Reaction products,Stereoselectivity Get e-Alerts
Nested linear/lattice codes for Wyner-Ziv encoding (2002)

We construct structured codes for lossy compression with uncoded side information at the decoder. These codes aim at achieving the optimal performance, given by the Wyner-Ziv (1976) rate-distortion function, for two typical settings. For binary symmetric source/side-information, we show that a pair of nested linear binary codes, each individually "good" in the classical sense, approaches the WZ-function relative to the Hamming distortion measure. For the quadratic Gaussian case we show a similar result at high SNR, using a pair of nested lattices and their associated lattice-decoding functions.
Anomalous Behaviour of Newcastle Disease Virus Haemagglutinin-Neuraminidase Protein in Western Blotting Analysis of Monoclonal Antibody Binding Sites (1986)

Previous studies with a particular monoclonal antibody (MAb 445) raised against the Ulster strain of Newcastle disease virus (NDV) have shown that this MAb immunoprecipitates only the 74,000 mol. wt. (74K) haemagglutinin-neuraminidase protein (HN) of both Ulster and Beaudette C strains of NDV. Using the technique of Western blotting, it is shown that under certain denaturing conditions virion proteins comigrating in SDS-polyacrylamide gels with the faster migrating 67K fusion protein and 53K nucleocapsid/nucleocapsid-associated protein, as well as the 74K HN, all reacted strongly with MAb 445 and with MAb 14 which is also directed against the HN protein. Analysis of this anomalous behaviour using SDS-polyacrylamide diagonal gel electrophoresis has led to the unexpected conclusion that the 74K HN can electrophorese as three immunoreactive species of apparent mol. wt. 74K, 67K and 53K. If the Western blotting technique is to be applied to proteins which have not been sufficiently denatured (in an attempt to preserve epitope integrity) it is important to establish that no additional proteins remain associated with the protein bands that react with the MAb.
Optical properties of porcine skin dermis between 900 nm and 1500 nm (2000)

The weak absorption of shortwave infrared light by skin tissues between 700 and 1500 nm offers an important window for diagnosis by optical means. The strong scattering of shortwave infrared light by the skin, however, presents a challenge to the modelling of light propagation through the skin and the understanding of skin optics. We have measured the collimated and diffuse transmittance and diffuse reflectance of porcine skin dermis samples within 30 h post-mortem. Monte Carlo simulations have been performed to inversely determine the absorption coefficient, scattering coefficient and anisotropy factor of the dermis samples in the spectral range from 900 to 1500 nm. We further analyse the sensitivity of the values of the parameters to the experimental errors and inverse calculation procedures. The state of the cellular integrity of the skin samples following optical measurements was verified using transmission electron microscopy. These results were correlated to study post-mortem effects on the in vitro optical properties of porcine dermis. We concluded that for samples stored within crushed ice for up to 30 h post-mortem the wavelength dependence of optical properties of the dermis remains unchanged while the values of the parameters vary moderately due to modification of the water content of the tissue.
Protein Pattern Assembly by Active Control of a Triblock Copolymer Monolayer (2006)

We present an electrically programmable technique that can rapidly assemble proteins into high-resolution, arbitrarily shaped patterns. Controlled protein adsorption is achieved by switching the nanoscale surface arrangement of a triblock copolymer monolayer on microelectrodes in an engineered microfluidic device via an electric potential. Our technique is the first capable of configuring differential protein densities into patterns by varying the applied control voltage, providing the possibility to tune signals for complex analytes, test conditions, or quantification.
Abdominal Aortic Aneurysm Rupture following Endoluminal Graft Deployment: Report of a Predictable Event (2000)

Type II endoleaks can lead to aneurysm rupture. Three-dimensional (3D) spiral CT angiography offers an opportunity to track endoleak volume and the effect of exposure to systemic pressure on the aneurysm sac.
Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study (2010)

This randomized, open-label, active-controlled, dose-finding phase IIb study evaluated the efficacy and safety of trabedersen (AP 12009) administered intratumorally by convection-enhanced delivery compared with standard chemotherapy in patients with recurrent/refractory high-grade glioma. One hundred and forty-five patients with central reference histopathology of recurrent/refractory glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA) were randomly assigned to receive trabedersen at doses of 10 or 80 µM or standard chemotherapy (temozolomide or procarbazine/lomustine/vincristine). Primary endpoint was 6-month tumor control rate, and secondary endpoints included response at further timepoints, survival, and safety. Six-month tumor control rates were not significantly different in the entire study population (AA and GBM). Prespecified AA subgroup analysis showed a significant benefit regarding the 14-month tumor control rate for 10 µM trabedersen vs chemotherapy (p= .0032). The 2-year survival rate had a trend for superiority for 10 µM trabedersen vs chemotherapy (p = .10). Median survival for 10 µM trabedersen was 39.1 months compared with 35.2 months for 80 µM trabedersen and 21.7 months for chemotherapy (not significant). In GBM patients, response and survival results were comparable among the 3 arms. Exploratory analysis on GBM patients aged ≤55 years with Karnofsky performance status >80% at baseline indicated a 3-fold survival at 2 and 3 years for 10 µM trabedersen vs chemotherapy. The frequency of patients with related or possibly drug-related adverse events was higher with standard chemotherapy (64%) than with 80 µM trabedersen (43%) and 10 µM trabedersen (27%). Superior efficacy and safety for 10 µM trabedersen over 80 µM trabedersen and chemotherapy and positive risk-benefit assessment suggest it as the optimal dose for further clinical development in high-grade glioma.
Chemie der α‐Aminonitrile 1. Mitteilung Einleitung und Wege zu Uroporphyrinogen‐octanitrilen (1987)

Chemistry of α‐Aminonitriles I: Introduction and Pathways to Uroporphyrinogen‐octanitriles. An introduction to experimental studies on the chemistry of α‐aminonitriles potentially relevant to the problems of prebiotic chemistry is presented. The framework of conditions wherein the investigation is chosen to be carried out implies both molecular oxygen and ‐ whenever feasible ‐ water to be excluded from reaction conditions. This study focusses on 2‐amino‐2‐propenenitrile ( 3 ) ( Scheme 6 ) as central starting material of reaction sequences which aim at the nitrile forms of proteinogenic amino acids as well as at the aza forms of building blocks of biological cofactor molecules as their targets ( Scheme 5 ). Schemes 13,16,23 as well as 25 and 26 summarize reaction sequences by which 3 is transformed within the defined framework of conditions into the thermodynamic (statistically controlled) mixture of the four isomeric uroperphyrinogen‐octanitriles 57–60 . HPLC's of such mixtures document the dominance of the least symmetrical isomer whose constitutional pattern of peripheral substituents happens to be the one percent in all biological porphinoids. Preparative procedures for the synthesis of 3 (Scheme 9), the β,β‐disubstituted pyrrol‐nitriles 30,53 and 54 ( Scheme 19 ) as well as the porphyrinogenoctakis(propionitrile) and‐octakis(acetonitrile) 65 and 66 , respectively ( Scheme 24 ) are given.
Molecular determinants of acute inflammatory responses to biomaterials. (1996)

The frequent inflammatory responses to implanted medical devices are puzzling in view of the inert and nontoxic nature of most biomaterials. Because implant surfaces spontaneously adsorb host proteins, this proteinaceous film is probably important in the subsequent attraction of phagocytes. In fact, earlier we found that acute inflammatory responses to experimental polyethylene terephthalate implants in mice require the precedent adsorption of one particular host protein, fibrinogen. The present investigations were aimed at defining the molecular determinants of fibrinogen-mediated acute inflammatory responses to implanted biomaterials. We find: (a) plasmin degradation of purified fibrinogen into defined domains reveals that the proinflammatory activity resides within the D fragment, which contains neither the fibrin cross-linking sites nor RGD sequences; (b) the major (and, perhaps, exclusive) proinflammatory sequence appears to be fibrinogen gamma 190-202, previously shown to interact with CD11b/CD18 (Mac-1). The chemically synthesized peptide, cross-linked to albumin (which itself does not promote inflammatory responses), mimics the proinflammatory effect of adsorbed native fibrinogen; and (c) this sequence probably promotes inflammatory responses through interactions with Mac-1 because phagocyte accumulation on experimental implants is almost completely abrogated by administration of recombinant neutrophil inhibitory factor (which blocks CD11b-fibrin(ogen) interaction). We conclude that improved knowledge of such surface-protein-phagocyte interactions may permit the future development of more biocompatible implantable materials.
Sum-rate analysis for full-duplex underlay device-to-device networks (2014)

A theoretical framework is presented for the evaluation of sum ergodic rate of a full-duplex underlay device-to-device network, when it shares the uplink resources of a conventional cellular user. The sum-rate of the full-duplex network is compared with a half-duplex network with equivalent radio frequency hardware complexity. Closed-form approximations are derived for the sum ergodic rate of the systems. Furthermore, the sum-rate performances are investigated for the case when a transmit power constraint is imposed on the underlay network to minimize the interference on the cellular network. The analytical results presented can be used as a tool to identify when full-duplex transmissions are viable in underlay device-to-device networks.
Comparative Effects of Levofloxacin and Ofloxacin on the Normal Oral and Intestinal Microflora (1997)

The aim of the study was to study the ecological effects of levofloxacin, compared to that of ofloxacin, on the oral and intestinal human microflora. 10 healthy volunteers received levofloxacin (500 mg) and 10 subjects were given ofloxacin (400 mg) perorally, once daily for 7 days. Saliva and stool samples were obtained prior to drug administration, during administration (days 2, 4 and 7), and after withdrawal of the agents (days 9, 11, 14 and 21). The concentrations of levofloxacin and ofloxacin in the saliva and faecal samples, respectively, were assayed, and quantitative and qualitative microbiological analyses were performed. Oral administration of levofloxacin and ofloxacin led to low drug concentrations in the saliva, which corresponded with mild disturbances in the oral microflora. High drug levels were obtained in the intestinal tract, and both agents caused a selective reduction in the normal microflora, mainly directed towards aerobic Gram-negative bacteria. There was no significant difference between levofloxacin and ofloxacin, regarding ecological effects on the normal oral and intestinal microflora. From an ecological point of view, these agents acted favourably, since no major selection of resistant strains occurred in the normal microflora during administration.
Portable vehicle navigation system (NV-1): Its features and operability (1993)

The NV-1 described is a vehicle navigation system which has been developed primarily for the aftersales market. The user can easily remove this stand-alone system from the vehicle. The system uses a CD-ROM disc on which is stored a map database whose format is standardized and widely compatible. The user can enjoy a variety of software by merely changing the disc. Use is also made of a variety of CD-ROMs containing additional information, which is classified according to intended application. Since this navigation sytem incorporates a speech recognition function, the user can perform a series of operations without touching the controls or looking at the screen.
Non‐anaphylactic surface‐exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination (2004)

Our results indicate the mechanistic importance of blocking antibodies for allergy vaccination and present a B cell epitope-based approach for the rational design of safe peptide allergy vaccines whenever the structure of the disease-eliciting allergen is known.
The Eosinophil Component of the Alveolitis in Idiopathic Pulmonary Fibrosis: Signs of Eosinophil Activation in the Lung Are Related to Impaired Lung Function (1989)

The number of eosinophils and the concentrations of eosinophil cationic protein (ECP), a specific granule constituent of eosinophil granulocytes, were measured in bronchoalveolar lavage (BAL) fluid from patients (n = 22) with idiopathic pulmonary fibrosis (IPF). The median recovery of eosinophils during lavage performance was 4% (range, zero to 49) of the nonepithelial cells and significantly increased compared with the recovery in healthy control subjects (less than 1%) and in control patients with sarcoidosis (1%; range, zero to 7). The median BAL fluid concentration of ECP was in IPF 13.3 micrograms/L (range, 2 to 118) and significantly increased compared with the concentrations in healthy control subjects (2.7 micrograms/L; range, less than 2 to 8) and in control patients (6.6 micrograms/L; range, less than 2 to 64). The BAL fluid concentrations of myeloperoxidase (MPO) were also significantly increased in IPF, indicating a local neutrophil activation. A significant correlation was found between BAL fluid ECP and MPO, suggesting a common activator of eosinophils and neutrophils. BAL fluid eosinophils and ECP correlated with the reduced diffusion capacity of the lung but not with vital capacity or forced expiratory volume. It is concluded that eosinophil activation is part of the inflammatory process in IPF. ECP and other cytotoxic eosinophil products may play a pathophysiologic role for the lung damage in this disease.
Implications of coverage-dependent O adsorption for catalytic NO oxidation on the late transition metals (2014)

Cluster-expansion-based kinetic model reveals that adsorbate interactions both promote and inhibit NO oxidation on the late transition metals.
Complementary-LVTSCR ESD protection scheme for submicron CMOS IC's (2002)

There is one LVTSCR (Low Voltage Trigger SCR) device merged with short-channel NMOS and another LVTSCR device merged with short-channel PMOS in a complementary style to offer effective and direct ESD discharging paths from the input or output pads to V/sub SS/ and V/sub DD/ powerlines. The DC switching voltage of LVTSCR devices is lowered to the snapback voltage of short-channel NMOS and PMOS devices. Experimental results show that it has an excellent ESD protection capability in a smaller layout area.
Long‐term treatment with GTS‐21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex (1996)

The synthetic nicotinic agonist GTS-21 and nicotine were compared in aged rats for their ability to enhance cognition and affect the density of brain nicotine receptor subtypes. At 15 min before to daily behavioral testing in the Morris water maze, aged rats were injected intraperitoneally with GTS-21 (2.6 μmoles/kg; 1.0 mg/kg), nicotine (1.2 μmoles/kg; 0.2 mg/kg), or saline. After 1 month of treatment, the density of α7 and α4β2 nicotinic receptor subtypes in the brain was determined using [125I]α-bungarotoxin and [3H]cytisine binding assays, respectively. Compared to saline controls, GTS-21 and nicotine-treated rats showed significantly greater water maze acquisition, but not greater memory retention. GTS-21 treatment caused an increase in the density of α4β2 binding sites in the neostriatum, but not in the neocortex, and did not affect α7 binding site densities in any of the brain areas analyzed. Nicotine treatment had no effect on either α4β2 binding site densities in the brain areas evaluated. Because GTS-21 acts preferentially on brain nicotinic receptors while having little activity at neuromuscular junction nicotinic receptors, these results indicate that GTS-21 may have therapeutic value to treat age-associated memory impairment and/or Alzheimer's disease. Drug Dev. Res. 39:19–28. © 1997 Wiley-Liss, Inc.
Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis (2015)

In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage. Serum levels of sLLT1 were increased in all patient groups (patients with early- and late-stage RA, seropositive arthralgia and spondyloarthropathy) when compared to healthy subjects.
Adult mesenchymal stem cells (2007)

Adult mesenchymal stem cells (MSCs) are a population of multipotent cells found primarily in the bone marrow. They have long been known to be capable of osteogenic, adipogenic and chondrogenic differentiation and are currently the subject of a number of trials to assess their potential use in the clinic. Recently, the plasticity of these cells has come under close scrutiny as it has been suggested that they may have a differentiation potential beyond the mesenchymal lineage. Myogenic and in particular cardiomyogenic potential has been shown in vitro. MSCs have also been shown to have the ability to form neural cells both in vitro and in vivo, although the molecular mechanisms underlying these apparent transdifferentiation events are yet to be elucidated. We describe here the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for future applications in regenerative medicine.
The chick chorioallantoic membrane as a novel in vivo model for the testing of biomaterials (2002)

Current in vivo models for testing biomaterials are time and labor intensive as well as expensive. This article describes a new approach for testing biomaterials in vivo using the chorioallantoic membrane (CAM) of the developing chicken embryo, as an alternative to the traditional mammalian models. Fertilized chicken eggs were incubated for 4 days, at which time a small window was cut in the shell of the egg. After 1 week of incubation, the CAM received several test materials, including the endotoxin LPS, a cotton thread and a Silastic tubing. One day and 1 week later, the tissue response to the test materials was assessed using gross, histological, and scanning electron microscope evaluations. The inflammatory response of the chorioallantoic membrane to biomaterials was fully characterized and found to be similar to that of the mammalian response and was also seen to vary according to test materials. We also found that the structure and geometry of the test materials greatly influenced the incorporation of the samples in the CAM. The similarity of the tissue response of the CAM with the mammalian models, plus the low cost, simplicity, and possibility to continuously visualize the test site through the shell window make this animal model particularly attractive for the rapid in vivo screening of biomaterials.
Retroviral-Mediated Gene Transfer for Engineering Tumor-Reactive T-Cells (2006)

Immunotherapy for cancer has taken several approaches including vaccinating patients to elicit T-cell responses to tumor antigens and adoptive transfer of tumor-reactive T-cells to patients. Vaccination has historically been ineffective in generating objective clinical responses. Whereas adoptive cell transfer therapy has shown some promise, the difficulties in obtaining the large number of requisite tumor-reactive T-cells warrant investigation into alternate models of immunotherapy. A novel approach is the retroviral-mediated transfer of genes encoding recognition of tumor antigens into peripheral blood T-cells. By cloning genes for T-cell receptors that mediate antitumor reactivity and introducing them into a patient’s own T-cells, we can rapidly generate the large number of T-cells necessary for adoptive transfer therapy for any patient, regardless of the patient’s immune status.
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. (1988)

Two overlapping cDNA clones encoding human DNA topoisomerase II were identified by two independent methods. In one, a human cDNA library in phage lambda was screened by hybridization with a mixed oligonucleotide probe encoding a stretch of seven amino acids found in yeast and Drosophila DNA topoisomerase II; in the other, a different human cDNA library in a lambda gt11 expression vector was screened for the expression of antigenic determinants that are recognized by rabbit antibodies specific to human DNA topoisomerase II. The entire coding sequences of the human DNA topoisomerase II gene were determined from these and several additional clones, identified through the use of the cloned human TOP2 gene sequences as probes. Hybridization between the cloned sequences and mRNA and genomic DNA indicates that the human enzyme is encoded by a single-copy gene. The location of the gene was mapped to chromosome 17q21-22 by in situ hybridization of a cloned fragment to metaphase chromosomes and by hybridization analysis with a panel of mouse-human hybrid cell lines, each retaining a subset of human chromosomes.