gebhart/patrepeval huggingface dataset:
Inversion of Configuration at the Metal in Diastereomeric Imido Alkylidene Monoaryloxide Monopyrrolide Complexes of Molybdenum (2008)

The two diastereomers of Mo(NAr)(CHCMe(2)Ph)(2,5-dimethylpyrrolide)(1), (S(M)R(1))-2 and (R(M)R(1))-2, respectively, where 1 is an enantiomerically pure (R) phenoxide and Ar = 2,6-diisopropylphenyl, form adducts with PMe(3). One of these ((R(M)R(1))-2(PMe(3))) has been isolated. An X-ray structure reveals that PMe(3) has added trans to the pyrrolide; it is a model for where an olefin would attack the metal. Trimethylphosphine will catalyze slow interconversion of (S(M)R(1))-2 and (R(M)R(1))-2 via formation of weak PMe(3) adducts. Reactions between (S(M)R(1))-2 or (R(M)R(1))-2 and ethylene yield Mo(NAr)(CH(2))(Me(2)Pyr)(1) species in which the configuration at Mo is inverted by ethylene at a rate of the order of the NMR time scale at 22 degrees C via formation of metallacyclobutane intermediates with imido and aryloxide ligands in axial positions. A reactant olefin is proposed to approach Mo and the product olefin to leave Mo trans to the pyrrolide.
Dinucleotide repeat polymorphism at the D14S45 locus (1991)

Journal Article Dinucleotide repeat polymorphism at the D14S45 locus Get access J.A. Luty, J.A. Luty Oregon Health Sciences UniversityPortland, OR 97201, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Litt M. Litt * Oregon Health Sciences UniversityPortland, OR 97201, USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 15, 11 August 1991, Page 4308, https://doi.org/10.1093/nar/19.15.4308 Published: 11 August 1991
Toward an understanding of musical gesture : mapping expressive intention with the digital baton (1996)

Thesis (M.S.)--Massachusetts Institute of Technology, Program in Media Arts & Sciences, 1996.
Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries (2019)

Providing ES after nerve repair improved regeneration and recovery in rats, with minimal differences in therapeutic efficacy to FK506, further demonstrating its clinical potential to improve management of nerve injuries.
Proteolytic Degradation of Amyloid -Protein (2012)

The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A growing number of AβDPs have been identified, which, under physiological and/or pathophysiological conditions, contribute significantly to the determination of endogenous cerebral Aβ levels. Despite more than a decade of investigation, the complete set of AβDPs remains to be established, and our understanding of even well-established AβDPs is incomplete. Nevertheless, the study of known AβDPs has contributed importantly to our understanding of the molecular pathogenesis of Alzheimer disease (AD) and has inspired the development of several novel therapeutic approaches to the regulation of cerebral Aβ levels. In this article, we discuss the general features of Aβ degradation and introduce the best-characterized AβDPs, focusing on their diverse properties and the numerous conceptual insights that have emerged from the study of each.
Transcriptional Profiling Reveals Novel Interactions between Wounding, Pathogen, Abiotic Stress, and Hormonal Responses in Arabidopsis, (2002)

Mechanical wounding not only damages plant tissues, but also provides pathways for pathogen invasion. To understand plant responses to wounding at a genomic level, we have surveyed the transcriptional response of 8,200 genes in Arabidopsis plants. Approximately 8% of these genes were altered by wounding at steady-state mRNA levels. Studies of expression patterns of these genes provide new information on the interactions between wounding and other signals, including pathogen attack, abiotic stress factors, and plant hormones. For example, a number of wound-responsive genes encode proteins involved in pathogen response. These include signaling molecules for the pathogen resistance pathway and enzymes required for cell wall modification and secondary metabolism. Many osmotic stress- and heat shock-regulated genes were highly responsive to wounding. Although a number of genes involved in ethylene, jasmonic acid, and abscisic acid pathways were activated, many in auxin responses were suppressed by wounding. These results further dissected the nature of mechanical wounding as a stress signal and identified new genes that may play a role in wounding and other signal transduction pathways.
Epidemiology of Chronic Daily Headache in the General Population (1999)

Almost 5% of the general population (9% of women) suffers from chronic daily headache, the proportion of chronic tension-type headache and transformed migraine being quite similar. Less than one third overuse analgesics. The prevalence of chronic daily headache subtypes shown here differs from data obtained from headache clinics, emphasizing that caution is needed in extrapolating data from specialized units to the general population.
Augmented surfaces (1999)

This paper describes our design and implementation of a computer augmented environment that allows users to smoothly interchange digital information among their portable computers, table and wall displays, and other physical objects. Supported by a camera-based object recognition system, users can easily integrate their portable computers with the pre-installed ones in the environment. Users can use displays projected on tables and walls as a spatially continuous extension of their portable computers. Using an interaction technique called hyperdragging, users can transfer information from one computer to another, by only knowing the physical relationship between them. We also provide a mechanism for attaching digital data to physical objects, such as a videotape or a document folder, to link physical and digital spaces.
Sexing of sperm by flow cytometry (1988)

Economics dictate that livestock producers will be under increasing pressure to optimise output. A technique for sex pre-selection could help by reducing the number of females required to produce a given number of progeny of the desired sex; the technique would be particularly useful to the dairy industry. Live mammalian sperm, stained with a vital dye and analysed by flow cytometry, show a bimodal fluorescence distribution. Such bimodality may represent two overlapping subpopulations of X- and Y-chromosome bearing sperm. To test this hypothesis, sperm from the two subpopulations were separated using the sorting capacity of a flow cytometer and were used for the insemination of suitably prepared females. The sex of the resulting progeny was determined either by anatomical criteria or by identification of the sex chromosomes by karyotyping. Insufficient data are available so far to provide statistically significant evidence in support of the hypothesis, but a preliminary sequential analysis indicates a progressive tendency towards significance.
DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri (2004)

These data support the hypothesis that aneuploidization precedes integration of HR-HPV genomes in the progression of cervical dysplasia. Accordingly, deregulated viral oncogene expression appears to result first in chromosomal instability and aneuploidization and is subsequently followed by integration of HR-HPV genomes in the affected cell clones.
Gene expression profiling identifies ARSD as a new marker of disease progression and the sphingolipid metabolism as a potential novel metabolism in chronic lymphocytic leukemia (2012)

ARSD is a novel prognostic factor as the time to start therapy is shorter in patients with high levels of ARSD protein and sphingolipid metabolism could represent a new biological mechanism in CLL.
Superior Characteristics of RuO2/GaN Schottky-Type UV Photodetector (2001)

A RuO2/GaN Schottky diode was designed and fabricated for application as a UV photodetector. The fabricated RuO2/GaN Schottky diode showed a breakdown at over —50 V, plus a leakage current of 9 nA/cm2 at —5 V with a good uniformity that was one order of magnitude lower than that of a Pt/GaN Schottky diode under the same epitaxial conditions. The proposed RuO2/GaN Schottky photodiode also exhibited a UV-visible rejection ratio of 3 × 105 and responsivity of 0.23 A/W at 330 nm.
Adaptive interpolation filters and high-resolution displacements for video coding (2006)

Standardized hybrid video coding systems are based on motion compensated prediction with fractional-pel displacement vector resolution. In the recent video coding standard H.264/AVC, a displacement vector resolution of 1/4-pel is applied. In order to estimate and compensate these fractional-pel displacements, interpolation filters are used. So far, these interpolation filters are invariant. The same filter with the same filter-coefficients is applied for all sequences and for all images of a sequence. Therefore, it is not possible to consider nonstationary statistical properties of the video signal and the motion compensated prediction process like aliasing, quantization errors, and displacement estimation errors. This paper presents two techniques that improve the motion compensated prediction and accordingly the coding efficiency. The first technique applies an adaptive interpolation filter that uses filter-coefficients which are adapted once per image. The adapted filter-coefficients are coded and transmitted. The second technique is based on an increased displacement vector resolution of 1/8-pel. In combination, the developed techniques indicate bit-rate reductions up to 25 % compared to H.264/AVC.
Agency plus automation: Designing artificial intelligence into interactive systems (2019)

Much contemporary rhetoric regards the prospects and pitfalls of using artificial intelligence techniques to automate an increasing range of tasks, especially those once considered the purview of people alone. These accounts are often wildly optimistic, understating outstanding challenges while turning a blind eye to the human labor that undergirds and sustains ostensibly "automated" services. This long-standing focus on purely automated methods unnecessarily cedes a promising design space: one in which computational assistance augments and enriches, rather than replaces, people's intellectual work. This tension between human agency and machine automation poses vital challenges for design and engineering. In this work, we consider the design of systems that enable rich, adaptive interaction between people and algorithms. We seek to balance the often-complementary strengths and weaknesses of each, while promoting human control and skillful action. We share case studies of interactive systems we have developed in three arenas-data wrangling, exploratory analysis, and natural language translation-that integrate proactive computational support into interactive systems. To improve outcomes and support learning by both people and machines, we describe the use of shared representations of tasks augmented with predictive models of human capabilities and actions. We conclude with a discussion of future prospects and scientific frontiers for intelligence augmentation research.
The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis (2018)

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix production, impairing function and contributing to pulmonary fibrosis. Hedgehog and Wnt signaling are developmental signal cascades that play an essential role in regulating embryogenesis and tissue homeostasis. Recently, it has been reported that both hedgehog and Wnt signaling play important roles in pulmonary fibrogenesis. Thus, the identification of specific target regulators may yield new strategy for pulmonary fibrosis therapies. In our work, we demonstrated the critical role of Gli1, Wnt7b, Wnt10a and Fzd10 in the process of pulmonary fibrogenesis in vitro and in vivo. Gli1 was induced in LR-MSCs following TGF-β1 treatment and fibrotic lung tissues. Inhibition of Gli1 suppressed myofibroblast differentiation of LR-MSCs and pulmonary fibrosis, and decreased the expression of Wnt7b, Wnt10a and β-catenin. Gli1 bound to and increased promoter activity of the Wnt7b and Wnt10a genes, and Wnt7b and Wnt10a were critical activators of Wnt/β-catenin signaling. It was noteworthy that Fzd10 knockdown reduced Wnt7b and Wnt10a-induced activation of Wnt/β-catenin signaling, which imply that Wnt7b and Wnt10a may be the ligands for Fzd10. Moreover, siRNA-mediated inhibition of Fzd10 prevented TGF-β1-induced myofibroblast differentiation of LR-MSCs in vitro and impaired bleomycin-induced pulmonary fibrosis. We conclude that hedgehog and Wnt/β-catenin signaling play a critical role in promoting myofibroblast differentiation of LR-MSCs and development of pulmonary fibrosis. These findings elucidate a therapeutic approach to attenuate pulmonary fibrosis through targeted inhibition of Gli1 or Fzd10.
Chemical composition of seeds of some species of the genusGossypium (1977)

SUMMARY Chemical analyses were carried out on the three main commercial varieties in the Sudan and some wild species of Gossypium. A genome-specific pattern was not found for either the oil content, fatty acids, amino acids or seed index. G. sturtianum differed significantly from the other species in oil content with a substantial amount of unsaturated fatty acids and of the essential amino acids. A breeding programme has been started to incorporate such desirable characters into the commercial varieties.
cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans (1996)

Several genes that encode members of the cadherin superfamily have been identified in Caenorhabditis elegans. Based on the roles of cadherins in vertebrates and Drosophila, it is expected that they function in the control of epithelial morphogenesis, an event which is poorly understood at the molecular level in C. elegans. Reporter genes under the control of upstream sequences from one of these genes, cdh-3, are expressed in developing epithelial cells, but also in a number of neuroectodermal cells that extend processes along some of these epithelial cells. We generated a loss-of-function mutation in cdh-3 by transposon-mediated deletion mutagenesis. This mutation affects the morphogenesis of a single cell, hyp10, which forms the tip of the nematode tail. The lack of detectable defects associated with the other cells expressing cdh-3 reporter constructs hints at the existence of other genes that can compensate for cdh-3 loss of function.
The Design, Development, and Field Testing of a Water-Cut Meter Based on a Microwave Technique (1990)

Abstract This paper will describe a new and unique instrument to accurately determine the water-cut of an oil-water emulsion. The basic principle of the measurement is based on a novel technique, commonly called oscillator load-pull, which detects the microwave characteristics of the emulsion. This measurement technique will be described simply and concisely. The design and development of the measurement pipe section and the necessary microwave oscillator source and control electronics will be discussed. Laboratory calibration data for the microwave water-cut meter will be presented. Installation of the instrument at a production facility will be described and field test results will be presented. Performance of the microwave water-cut meter will be compared to other water-in-crude determination methods including distillation and centrifugal separation.
Longterm Survival Among Patients with Scleroderma-associated Pulmonary Arterial Hypertension Treated with Intravenous Epoprostenol (2009)

This study reports longterm survival rates for patients with scleroderma-associated PAH treated with i.v. epoprostenol. Although comparisons to historical data should be made with caution, this study reports a better survival outcome than natural history data on patients with scleroderma-associated PAH.
Deletion of the p16 and p15 Genes in Human Bladder Tumors (1995)

Alteration of the p16 and p15 genes, especially coincident homozygous deletion, appears to be a common event in bladder cancer.
Disruption of a Magnaporthe grisea cutinase gene. (1992)

Using a one-step strategy to disrupt CUT1, a gene for cutinase, cut1- mutants were generated in two strains of Magnaporthe grisea. One strain, pathogenic on weeping lovegrass and barley and containing the arg3-12 mutation, was transformed with a disruption vector in which the Aspergillus nidulans ArgB+ gene was inserted into CUT1. Prototrophic transformants were screened by Southern hybridization, and 3 of 53 tested contained a disrupted CUT1 gene (cut1::ArgB+). A second strain, pathogenic on rice, was transformed with a disruption vector in which a gene for hyg B resistance was inserted into CUT1. Two of the 57 transformants screened by Southern hybridization contained a disrupted CUT1 gene (cut1::Hyg). CUT1 mRNA was not detectable in transformants that contained a disrupted gene. Transformants with a disrupted CUT1 gene failed to produce a cutin-inducible esterase that is normally detected by activity staining on non-denaturing polyacrylamide gels. Enzyme activity, measured either with tritiated cutin or with p-nitrophenyl butyrate as a substrate, was reduced but not eliminated in strains with a disrupted CUT1 gene. The infection efficiency of the cut1- disruption transformants was equal to that of the parent strains on all three host plants. Lesions produced by these mutants had an appearance and a sporulation rate similar to those produced by the parent strains. We conclude that the M. grisea CUT1 gene is not required for pathogenicity.
3-D simulation of strained Si/SiGe heterojunction FinFETs (2004)

The 3D structure and simulation of strained Si/SiGe FinFETs is proposed in this paper. A channel doping of 10/sup 16/ cm/sup -3/, dual polysilicon gate 1.5 nm gate oxide, abrupt source/drain-to-channel junctions, and a Si/sub 0.8/Ge/sub 0.2/ body with fixed 5 nm surrounding Si are used in the 3D simulation. Strained Si/SiGe device at the threshold voltage (V/sub T/) yields a better gate control, smaller roll-off characteristics, smaller subthreshold swing, and significant g/sub m/ enhancement. This novel strained Si/SiGe FinFET with the enhanced carrier mobility and heterojunction confinement is demonstrated with greatly improved performance for NMOS by 3-D simulation.
A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics (1998)

A unified view of polymer, dumbbell, and oligonucleotide nearest-neighbor (NN) thermodynamics is presented. DNA NN DeltaG degrees 37 parameters from seven laboratories are presented in the same format so that careful comparisons can be made. The seven studies used data from natural polymers, synthetic polymers, oligonucleotide dumbbells, and oligonucleotide duplexes to derive NN parameters; used different methods of data analysis; used different salt concentrations; and presented the NN thermodynamics in different formats. As a result of these differences, there has been much confusion regarding the NN thermodynamics of DNA polymers and oligomers. Herein I show that six of the studies are actually in remarkable agreement with one another and explanations are provided in cases where discrepancies remain. Further, a single set of parameters, derived from 108 oligonucleotide duplexes, adequately describes polymer and oligomer thermodynamics. Empirical salt dependencies are also derived for oligonucleotides and polymers.
Fat Liquefaction: Effect of Low-Level Laser Energy on Adipose Tissue (2002)

Low-level laser energy has been increasingly used in the treatment of a broad range of conditions and has improved wound healing, reduced edema, and relieved pain of various etiologies. This study examined whether 635-nm low-level lasers had an effect on adipose tissue in vivo and the procedural implementation of lipoplasty/liposuction techniques. The experiment investigated the effect of 635-nm, 10-mW diode laser radiation with exclusive energy dispersing optics. Total energy values of 1.2 J/cm(2), 2.4 J/cm(2), and 3.6 J/cm(2) were applied on human adipose tissue taken from lipectomy samples of 12 healthy women. The tissue samples were irradiated for 0, 2, 4, and 6 minutes with and without tumescent solution and were studied using the protocols of transmission electron microscopy and scanning electron microscopy. Nonirradiated tissue samples were taken for reference. More than 180 images were recorded and professionally evaluated. All microscopic results showed that without laser exposure the normal adipose tissue appeared as a grape-shaped node. After 4 minutes of laser exposure, 80 percent of the fat was released from the adipose cells; at 6 minutes of laser exposure, 99 percent of the fat was released from the adipocyte. The released fat was collected in the interstitial space. Transmission electron microscopic images of the adipose tissue taken at x60,000 showed a transitory pore and complete deflation of the adipocytes. The low-level laser energy affected the adipose cell by causing a transitory pore in the cell membrane to open, which permitted the fat content to go from inside to outside the cell. The cells in the interstitial space and the capillaries remained intact. Low-level laser-assisted lipoplasty has a significant impact on the procedural implementation of lipoplasty techniques.
Convergent functional groups. 2. Structure and selectivity in olefin epoxidation with peracids (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvergent functional groups. 2. Structure and selectivity in olefin epoxidation with peracidsJ. Rebek Jr., L. Marshall, J. McManis, and R. WolakCite this: J. Org. Chem. 1986, 51, 10, 1649–1653Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jo00360a003https://doi.org/10.1021/jo00360a003research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts