gebhart/patrepeval huggingface dataset:
Proline-directed phosphorylation of human Tau protein. (1992)

The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A). When phosphorylated by proline-directed protein kinase in vitro, tau was found to incorporate up to 4.4 mol of phosphate/mol of protein. Isoelectric focusing of the tryptic phosphopeptides demonstrated the presence of five distinct peptides with pI values of approximately 6.9, 6.5, 5.6-5.9, 4.7, and 3.6. Mapping of the tryptic phosphopeptides by high performance liquid chromatography techniques demonstrated three distinct peaks. Data from gas phase sequencing, amino acid analysis, and phosphoamino acid analysis suggest that proline-directed protein kinase phosphorylates tau at four sites. Each site demonstrates the presence of a proline residue on the carboxyl-terminal side of the phosphorylated residue. Two phosphorylation sites are located adjacent to the three-repeat microtubule-binding domain that has been found to be required for the in vivo co-localization of tau protein to microtubules. Two other putative phosphorylation sites are located within the identified epitope of the monoclonal antibody Tau-1. Phosphorylation of these sites altered the immunoreactivity of tau to Tau-1 antibody. Since the neuronal microtubule-associated protein tau is multiply phosphorylated in Alzheimer's disease, and Tau-1 immunoreactivity is similarly reduced in neurofibrillary tangles and enhanced after dephosphorylation, phosphorylation at one or more of these sites may correlate with abnormally phosphorylated sites in tau protein in Alzheimer's disease.
Triterpenoids Display Single Agent Activity in a Mouse Model of CLL/SBL. (2006)

Abstract The synthetic triterpenoid 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic Acid (CDDO) induces apoptosis of leukemia cells through a novel mechanism and has recently entered Phase I human clinical trials. We studied the effects of CDDO and its imidazolide derivative (CDDO-Im) on cultured human chronic lymphocytic leukemia (CLL) cells and on B cells from TRAF2DN/Bcl-2 transgenic mice, a new mouse model of CLL and small B cell lymphoma (SBL). Both triterpenoids efficiently induced death of malignant human and mouse B-cells ex vivo, although CDDO-Im was over 10-fold more potent than CDDO. Treating TRAF2DN/Bcl-2 mice that had developed leukemia with liposome-formulated CDDO or CDDO-Im resulted in significant reductions of B cells in blood, spleen and lung, with CDDO-Im more potent than CDDO, while treatment with empty liposomes had no impact on disease. Analysis of blood cells recovered from treated mice showed that CDDO-Im is a potent inducer of cell dead in vivo. Furthermore, CDDO-Im efficiently eradicated mouse CLL cells but had a lesser effect on the viability of normal B cells. These results demonstrate that triterpenoids CDDO and CDDO-Im reduce leukemia and lymphoma burden in vivo in a transgenic mouse model of CLL/SBL and suggest that CDDO-based synthetic triterpenoids should be tested for clinical activity in patients with CLL. Our results also provide evidence of the suitability of our mouse model of CLL/SBL as a preclinical platform for chemotherapeutic drug testing.
Design and test of novel integrate and dump filter (I&D) for optical Gbit/s system applications (1991)

An innovative integrated and dump circuit (I&amp;D) attractive for Gbit/s applications is presented. The new circuit avoids the dumping signal. Initial tests indicate that the I&amp;D improves the receiver sensitivity of 1Gbit/s baseband and optical DPSK systems.
Detailed Implosion Modeling of DT-Layered Experiments on the National Ignition Facility (2012)

Abstract not provided
Purification and Properties of Rat D-3-Hydroxyacyl-CoA Dehydratase: D-3-Hydroxyacyl-CoA Dehydratase/D-3-Hydroxyacyl-CoA Dehydrogenase Bifunctional Protein (1996)

We have previously purified two D-3-hydroxyacyl-CoA dehydratase preparations from human liver. One preparation contained a 77-kDa polypeptide and smaller polypeptides, and the other was a homodimer of a 46-kDa polypeptide. Three different purified rat peroxisomal D-3-hydroxyacyl-CoA dehydratase preparations have been reported. Therefore, rat enzyme was purified in this study to confirm the enzyme structure. Two preparations with similar molecular structures to the human enzyme preparations were obtained, and these were similar to each other in immunochemical and catalytic properties. It was suggested that the native enzyme was a homodimer of the 77-kDa polypeptide, and this enzyme was modified to a homodimer of the 46-kDa polypeptide, because conversion of the 77-kDa polypeptide to smaller polypeptides including the 46-kDa polypeptide was clearly observed during purification. Rat liver subcellular fractionation study indicates that this enzyme is located in peroxisomes. The enzyme preparation containing the 77-kDa polypeptide catalyzed the D-3-hydroxyacyl-CoA dehydrogenase reaction as well as the dehydratase reaction. Thus, it is proposed that this enzyme is D-3-hydroxyacyl-CoA dehydratase/ D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.
Lifetime of an excited molecule near a metal mirror: Energy transfer in the Eu3+/silver system (1974)

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Percutaneous Penetration of Methyl Nicotinate at Three Anatomic Sites: Evidence for an Appendageal Contribution to Transport? (1991)

Percutaneous absorption of the vasodilator methyl nicotinate (MN) was evaluated in human volunteers at three anatomic sites (forehead, forearm and palm) using the technique of laser Doppler flowmetry (LDF). The experiments were designed to test the hypothesis that the kinetics and extent of skin penetration are dependent upon the appendageal density at the site of application. The LDF technique measured the increase in skin blood flow elicited by topically applied MN once the chemical had penetrated to the microvasculature. Significant differences in the measured LDF responses at the three sites were found, and further analysis of the data suggested that MN penetration was greatest through forehead skin, least through the palm and intermediate across the skin of the forearm. A correlation therefore existed between apparent MN absorption and appendageal density.
DOD standard transmission control protocol (1980)

article DOD standard transmission control protocol Share on Author: Jon Postel View Profile Authors Info & Claims ACM SIGCOMM Computer Communication ReviewVolume 10Issue 4October 1980 pp 52–132https://doi.org/10.1145/1040132.1040134Published:01 October 1980 47citation390DownloadsMetricsTotal Citations47Total Downloads390Last 12 Months33Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Sonodynamic Antitumor Effect of Protoporphyrin IX Disodium Salt on S180 Solid Tumor (2007)

The results implied that the antitumor effect of ultrasound could be enhanced in the presence of PPIX which might be involved in a sonochemical mechanism.
Syntheses of Pyrrolo[2,3‐d]pyrimidine 2′,3′‐Dideoxyribonucleosides Related to 2′,3′‐Dideoxyadenosine and 2′,3′‐Dideoxyguanosine and Inhibitory Activity of 5′‐Triphosphates on HIV‐1 Reverse Transcriptase (1991)

Abstract The synthesis of 4‐chloropyrroIo[2,3‐ d ]pyrimidine and 2‐amino‐4‐chloropyrrolo[2,3‐ d ]pyrimidine α‐ D ‐ and β‐ D ‐2′,3′‐dideoxyribonucleosides 6a , b and 7a , b is described ( Scheme 1 ). Glycosylation of the pyrrolo[2,3‐ d ]‐pyrimidinyl anions of 1a , b with in situ prepared 2,3‐dideoxy‐α/β‐ D ‐ glycero ‐pentofuranosyl chloride ( 2 ) was regioselective but afforded anomeric mixtures of the 2′,3′‐dideoxyribonucleosides 3a / 4a and 3b / 4b , respectively. The glycosylation products were deprotected and subjected to nucleophilic displacement yielding various pyrrolo[2,3‐ d ]pyrimidine 2′,3′‐deoxyribonucleosides related to 2′,3′‐dideoxyadenosine and 2′,3′‐dideoxyguanosine. One‐pot phosphorylation gave the corresponding triphosphates. Some of them are strong inhibitors of HIV‐1 reverse transcriptase, similar to corresponding purine 2′,3′‐dideoxynucleotides, but exhibit a better selectivity index in comparison to DNA polymerases. According to that, the N( 7 ) of the purine moiety is not an essential binding position of ddATP or ddGTP at the active centre of HIV‐1 reverse transcriptase.
TheNPAS3gene—emerging evidence for a role in psychiatric illness (2006)

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.
Room-Temperature Chemiresistive Effect of ${\rm TiO}_{2}\!-\!{\rm B}$ Nanowires to Nitroaromatic and Nitroamine Explosives (2010)

Semiconducting <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm TiO}_{2}\!\!-\!\!{\rm B}$</tex></formula> nanowires were synthesized and their chemical sensor performance was studied. It was found that the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">${\rm TiO}_{2}\!-\!{\rm B}$</tex></formula> nanowires exhibited a large and reversible change in electrical resistivity when exposed to trace vapor of nitroaromatic and nitroamine explosives. The sensor showed high sensitivity and fast response at room temperature. The chemiresistive effect was attributed to the adsorption of high electronegativity explosives on the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm TiO}_{2}\!-\!{\rm B}$</tex></formula> nanowires and a consequent depletion of charge carriers in the nanowires by surface states created by the explosive molecules. The role of the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm TiO}_{2}\!-\!{\rm B}$</tex></formula> nanowires is proposed to impart both an extremely large surface area for the adsorption of gas molecules and a surface enriched in hydroxyl groups which connect to nitro groups of the explosive molecules. Chemiresistive sensors made of <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">${\rm TiO}_{2}\!-\!{\rm B}$</tex></formula> semiconducting nanowires promised to achieve micro-sized devices with several orders of magnitude reduction in dimensions, weight, and power consumption over current explosive detectors.
Least square method that based on relative error (2003)

Least square method has been using in each domain of science and technology, but only suitable for equal pricision data-because the evaluation is on the basis of the roughly the same absolute error. But most data of science research and observation is often evaluated by the relative error of the observation amount, that is , the larger the observation amount is, the larger the permissible and real observation error is. From this point of view, if we set up a new least square method, taking the least square sum of relative fitness error as premise, then we can just expect that, the new method will possess more wide ranging use and more practical significance. This article shows the practical result of the new least square method.
Direct demonstration of a correspondence between the dopamine islands and acetylcholinesterase patches in the developing striatum. (1981)

The distribution of dopamine-containing processes in the striatum of fetal and neonatal cats was studied by immunohistochemical and glyoxylic acid histofluorescence methods and compared to the distribution of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) observed by thiocholine histochemistry in the same or serially adjoining sections. Both methods for demonstrating the dopamine innervation revealed the characteristic patchwork of dopamine "islands" in the caudoputamen, in which catecholamine histofluorescence or tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2]-like immunoreactivity was concentrated into 0.2- to 0.6-mm-wide patches. Both methods also demonstrated a high degree of patterning of the dopamine innervation in the ventral striatum, including the nucleus accumbens septi. A detailed and striking match was found between these configurations and the compartmental distribution of acetylcholinesterase observed in the caudoputamen and ventral striatum of the same brains. The correspondence between the dopamine and acetylcholinesterase figures was most obvious in the fetal brains, in which the background acetylcholinesterase staining was lightest, but matches between the dopamine islands and acetylcholinesterase patches could still be seen in the kittens. There was no clear alignment of striatal cell bodies stained for acetylcholinesterase with either the dopamine or the acetylcholinesterase-positive patches. Nor was there an obvious correspondence between dopamine and acetylcholinesterase in the striatal background matrix. We conclude that, at least during ontogenesis, it is the clustered arrangements of dopamine and acetylcholinesterase that are, in particular, tightly linked, and we suggest that information about the maturation of these clusters may be crucial in assessing the functions of striatal dopamine and acetylcholinesterase in the adult.
Isoform-specific Activation and Structural Diversity of Calmodulin Kinase I (1997)

We earlier confirmed that there are isoforms of Ca2+/calmodulin (CaM)-dependent protein kinase I (CaM kinase I) (CaM kinase Ibeta1 and Igamma) beside CaM kinase Ialpha by cDNA cloning (Yokokura, H., Terada, O., Naito, Y., and Hidaka, H. (1997) Biochim. Biophys. Acta 1338, 8-12). Here, we demonstrate the existence of an isoform-specific activation mechanism of CaM kinase I and alternative splicing specifically regulating CaM kinase I (CaM kinase Ibeta2) in the central nervous system. To cast light on isoform structure-enzyme activity relationships, CaM kinase Ibeta1, Ibeta2, and Ialpha were expressed separately using a baculovirus/Sf9 cell expression system. The novel CaM kinase Ibeta2 isoform demonstrated similar catalytic activity to those of CaM kinase Ibeta1 and Ialpha. Interestingly, CaM kinase Ibeta1 and Ibeta2 both can activate CaM kinase Ialpha activity via phosphorylation at Thr177. Reverse transcribed-polymerase chain reaction analysis showed that CaM kinase Ibeta2 is dominant in the cerebrum and cerebellum, whereas CaM kinase Ibeta1 is present in peripheral tissues such as liver, heart, lung, kidney, spleen, and testis. CaM kinase Ibeta2 was also detected with an anti-CaM kinase Ibeta2 antibody in PC12 cells. The results indicate that alternative splicing is a means for tissue-specific expression of CaM kinase Ibeta. Thus the Thr177 residue of CaM kinase Ialpha is phosphorylated by not only CaM kinase kinase but also CaM kinase Ibeta for activation of the enzyme.
Normalised Givens rotations for recursive least squares processing (2002)

An algorithm for recursive least squares optimisation based on the method of QR decomposition by Givens rotations is reformulated in terms of parameters whose magnitude is never greater than one. In view of the direct analogy to statistical normalisation, it is referred to as the normalised Givens rotation algorithm. An important consequence of the normalisation is that most of the resulting least squares computation may be carried out using fixed point arithmetic. This should enable the design of a much simpler application specific integrated circuit to implement the Givens rotation processor for adaptive filtering and beamforming.
Interventions for mycosis fungoides (2012)

This review identified trial evidence for a range of different topical and systemic interventions for mycosis fungoides. Because of substantial heterogeneity in design, small sample sizes, and low methodological quality, the comparative safety and efficacy of these interventions cannot be established on the basis of the included RCTs. Taking into account the possible serious adverse effects and the limited availability of efficacy data, topical and skin-directed treatments are recommended first, especially in the early stages of disease. More aggressive therapeutic regimens may show improvement or clearance of lesions, but they also result in more adverse effects; therefore, they are to be considered with caution. Larger studies with comparable, clearly-defined end points for all stages of mycosis fungoides, and a focus on safety, quality of life, and duration of remission as part of the outcome measures, are necessary.
Polymeric Materials Encyclopedia, Twelve Volume Set (1996)

Additives Biodegradable Polymers Biomaterials for the Body Biomimetic Materials Biosensors Blends Block Copolymers Block Copolymer Micelles Comb-like Polymers Commercial Resins, Plastics, Elastomers Composites Compatibilizers Conducting Polymers Contact Lens Materials Controlled Release Dendrictic Polymers Dendrimers Dental Polymers Immobilized Enzymes Electrorheological Fluids Engineering Plastics Ferroelectric Polymers Ferromagnetic Polymers Fillers Flame-Resistant Material Flocculants Fluorine-containing Polymers Functional Polymers Gas Barrier Polymers Gas Separation Membranes Gelling Agents Group Transfer Polymerization Cyclopolymerization Hair and Skin Care Polymers Hairy Rod-Like Polymers High Solids Coatings Host-Guest Chemistry Hydrophilic Polymers Hydrophilic Surfaces Hydrogels Hyper-Branched Polymers Immortal Polymerization Inclusion Polymerization Inorganic/Organic Hybrids Interpenetrating Polymer Networks Ionomers Ladder Polymers Liquid Crystalline Polymers Living Polymers (Radical, Cation, Anion, and Coordination) Macrocyclic Polymers Macromonomers Membranes Metallocene Catalysis Metal Complexation Polymers Microbial Polymers Microencapsulated particles Microspheres Molecular Assemblies Molecular Complexes Molecular Composites Molecular Recognition Monodisperse Particles Monodisperse Polymers Network Polymers New Catalysts Systems New Fabrics New Initiating Systems New Living Polymer Systems New Polymerization Methods New Resins Nonlinear Optical Materials Nonthrombogenic Polymers Nucleic Acid Analogs Olefin-Carbon Monoxide Copolymers Optically Active Polymers Organometallic Polymers Pervaporation Membranes Phase Transfer Catalysts Phosphorous-Containing Polymers Photochromic Polymers Photoinitiators New Polymer Systems Poly (Ether Ketone) Poly (Ether Sulfone) Polyelectrolytes Polyelectrolyte Complexes Polyesters Polyimides Polymers from Natural Resources Polysilanes Preceramic Polymers Recycling Ring-Opening Polymerization Smart Materials Star Polymers Supramolecular Assembly Surface Modification Polymeric Surfactants Suture Materials Thermoplastic Composites Thermoreversible Gels Water-Borne Coatings Ziegler-Natta Catalysts Zwitterionic Polymerization
In Vivo Measurements of Vascular Oxygen Tension in Tumors Using MRI of a Fluorinated Blood Substitute (1989)

The authors measured the level of blood oxygenation in vivo in a series of rats with implanted mammary adenocarcinoma. The technique used was 19F magnetic resonance imaging of a perfluorochemical blood substitute. The method is based on the effect of oxygen on the T1 relaxation time of the fluorochemical and allows the determination of mean vascular PO2 independent of the blood volume in the tissue. The PO2 levels in the liver, lung, and spleen also were determined and were consistent with previously reported results. When the rats breathed air, the tumor PO2 levels were somewhat lower than in the other organs and were in a range typical of venous blood. When the rat was given 100% oxygen to breathe, the tumor PO2 levels increased far less than the PO2 levels of the other organs. This may indicate a greatly diminished blood flow to this particular tumor.
Formation of Stable Platinum Nanoparticles by Laser Ablation in Water (2003)

Platinum nanoparticles were produced by laser ablation of a platinum metal plate in an aqueous solution of sodium dodecyl sulfate (SDS). The absorption spectrum of the platinum nanoparticles was essentially the same as that of platinum nanoparticles chemically prepared in a solution. The size distribution of the nanoparticles thus produced was measured to be in the range of 1−7 nm in diameter by an electron microscope. The abundance of the nanoparticles changes with the concentration of SDS in the solution. Stable platinum nanoparticles were found to be produced by this method even in pure water.
An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS (2006)

To realize multiplexed sample preparation on a digital microfluidic chip for high-throughput Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS), several fluidic functions need to be integrated. These include the generation of multiple droplets from a reservoir and parallel in-line sample purification. In this paper, we develop two critical new functions in handling protein solutions and standard proteomic reagents with electrowetting-on-dielectric (EWOD) actuation, leading to an integrated chip for multiplexed sample preparation for MALDI-MS. The first is a voltage sequence designed to generate a series of droplets from each of the three reservoirs--proteomic sample, rinsing fluid, and MALDI reagents. It is the first time that proteomic reagents have been dispensed using EWOD in an air (as opposed to oil) environment. The second is a box-in-box electrode pattern developed to allow droplet passing over dried sample spots, making the process of in-line sample purification robust for parallel processing. As a result, parallel processing of multiple sample droplets is demonstrated on the integrated EWOD-MALDI-MS chip, an important step towards high-throughput MALDI-MS. The MS results, collected directly from the integrated devices, are of good quality, suggesting that the tedious process of sample preparation can be automated on-chip for MALDI-MS applications as well as other high-throughput proteomics applications.
The synthesis of the new zeolite, ERS-7, and the determination of its structure by simulated annealing and synchrotron X-ray powder diffraction (1998)

The new zeolite ERS-7 (EniRicerche-molecular-Sieve-7), which was synthesized within a narrow temperature and compositional range using N,N-dimethylpiperidinium as a structure directing agent, has a structure consisting of 17-sided (46546582) picnic-basket-shaped cages connected by 8-membered ring windows.