gebhart/patrepeval huggingface dataset:
Catalytic Dehydrogenation of Cycloalkanes to Arenes by a Dihydrido Iridium P−C−P Pincer Complex (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTCatalytic Dehydrogenation of Cycloalkanes to Arenes by a Dihydrido Iridium P−C−P Pincer ComplexMukta Gupta, Chrystel Hagen, William C. Kaska, Roger E. Cramer, and Craig M. JensenView Author Information Department of Chemistry, University of Hawaii Honolulu, Hawaii 96822 Department of Chemistry, University of California Santa Barbara, California 93106 Cite this: J. Am. Chem. Soc. 1997, 119, 4, 840–841Publication Date (Web):January 29, 1997Publication History Received25 July 1996Published online29 January 1997Published inissue 1 January 1997https://pubs.acs.org/doi/10.1021/ja962560xhttps://doi.org/10.1021/ja962560xrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views4975Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Catalysts,Hydrocarbons,Hydrogen,Organic reactions Get e-Alerts
A Single-Stage Grid Connected Inverter Topology for Solar PV Systems With Maximum Power Point Tracking (2007)

This paper proposes a high performance, single-stage inverter topology for grid connected PV systems. The proposed configuration can not only boost the usually low photovoltaic (PV) array voltage, but can also convert the solar dc power into high quality ac power for feeding into the grid, while tracking the maximum power from the PV array. Total harmonic distortion of the current, fed into the grid, is restricted as per the IEEE-519 standard. The proposed topology has several desirable features such as better utilization of the PV array, higher efficiency, low cost and compact size. Further, due to the very nature of the proposed topology, the PV array appears as a floating source to the grid, thereby enhancing the overall safety of the system. A survey of the existing topologies, suitable for single-stage, grid connected PV applications, is carried out and a detailed comparison with the proposed topology is presented. A complete steady-state analysis, including the design procedure and expressions for peak device stresses, is included. Necessary condition on the modulation index "M" for sinusoidal pulsewidth modulated control of the proposed inverter topology has also been derived for discontinuous conduction mode operation. All the analytical, simulation and experimental results are presented.
Immunotherapy of a murine lymphoma by adoptive transfer of syngeneic macrophages activated with bisantrene. (1986)

Macrophages from mice treated with a novel antineoplastic agent, bisantrene, were shown previously to be highly active in inhibiting the proliferation of tumor cells in culture. These activated cells have now been found to protect mice from dying of progressive tumors when injected into animals. The effect was observed not only in a Winn-type tumor cell neutralization assay but also in a setting of therapeutic intervention. Multiple treatments with bisantrene-activated cells seemed more effective than a single treatment. Macrophages appeared to be the major effectors in this system, since treatment with carrageenan abolished the protective effect. Thus, present findings suggest that in addition to a direct cytotoxic effect of bisantrene, the activation of macrophages may contribute to the overall antitumor activity of the drug.
Silicon nanowire devices (2000)

Transport measurements were carried out on 15–35 nm diameter silicon nanowires grown using SiH4 chemical vapor deposition via Au or Zn particle-nucleated vapor-liquid-solid growth at 440 °C. Both Al and Ti/Au contacts to the wires were investigated. The wires, as produced, were essentially intrinsic, although Au nucleated wires exhibited a slightly higher conductance. Thermal treatment of the fabricated devices resulted in better electrical contacts, as well as diffusion of dopant atoms into the nanowires, and increased the nanowire conductance by as much as 104. Three terminal devices indicate that the doping of the wires is p type.
A Phase I Trial of In Vivo Gene Therapy with the Herpes Simplex Thymidine Kinase/Ganciclovir System for the Treatment of Refractory or Recurrent Ovarian Cancer. Iowa Methodist Medical Center, Des Moines, Iowa (1996)

III. Scientific Abstract This study will evaluate the safety and efficacy of in vivo gene transfer of the Herpes Simplex-thymidine kinase (HStk) gene using PA317/LTKOSN.2 vector producing cells (VPC) in patients with recurrent or refractory ovarian cancer. Insertion of the HStk gene into tumor cells confers a sensitivity to the anti-herpes drug ganciclovir (GCV). The HStk/GCV system induces a bystander effect and an anti-tumor immune response. HStk VPC have destroyed intraperitoneal tumors growing in animals. This selective destruction of growing tumors in situ is thought to result from the production of toxic GCV metabolites within the tumor. This procedure has resulted in the cure of experimental animals with limited toxicity. Therefore, we propose to apply this technique for the treatment of refractory or relapsed ovarian cancer. Adult women (≥18 years) with recurrent or refractory ovarian cancer, will be evaluated for the extent and location(s) of their disease before being entered into the study. Patients will have a CT scan and peritonoscopy with biopsy to confirm the diagnosis. During peritonoscopy, eligible patients will have a Tenckhoff catheter placed. HStk VPC will be infused into the peritoneal space. Two weeks later, GCV will be administered at 5 mg/kg/dose IV b.i.d. for 14 days. Patients will only receive one cycle of therapy in this dose escalation protocol. After the completion of the course of GCV, the patient will then be followed at least every 4 weeks for the first 6 months and then at 2 to 6 month intervals. This protocol is related in principle to RAC approved protocols for the treatment of brain tumors in adults and children. This protocol is novel in the site of administration of the HStk VPC and the dose escalation schema.
Effects of urogastrone-epidermal growth factor on intestinal brush border enzymes and mitotic activity. (1991)

The wet weight of the stomach, small intestine, caecum, and colon were significantly reduced (p less than 0.001) in intravenously fed rats compared with orally fed controls. Human epidermal growth factor (urogastrone) reversed this atrophy. Detailed analysis of the small intestine showed a similar effect on intestinal crypt cell population, mitoses per crypt, and protein content. Brush border gamma glutamyltransferase and alpha glucosidase activities were reduced by up to 50% throughout the small intestine of the animals fed intravenously. The specific activities (mU/mg protein) were unchanged, as a concomitant decrease in the tissue weight and protein content also occurred. Intestinal brush border enzyme activities in the rats treated with urogastrone-epidermal growth factor were restored to those seen in the orally fed rats except for alpha glucosidase activity in the proximal gut. In addition, the specific activity of gamma glutamyltransferase was highly significantly increased (p less than 0.01) in all regions of the small intestine. Thus, although urogastrone administration prevents the decrease in brush border enzyme activity seen after the removal of luminal nutrition, the response seems to differ depending on the intestinal location, with the specific activities of some enzymes being higher than those seen in orally fed rats. Urogastrone-epidermal growth factor can thus significantly increase the functional ability of the intestine in addition to its trophic effects.
New insights into bone morphogenetic protein signaling: focus on angiogenesis (2009)

Better understanding of the BMP signaling pathway and its regulators can have potentially great effects on therapeutic strategies from cardiovascular disease to cancer.
Amino‐terminal deletion of 53% of dystrophin results in an intermediate Duchenne‐Becker muscular dystrophy phenotype (1994)

We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production of a dystrophin protein composing only 53% of the normal polypeptide chain. Such an inframe deletion would be expected to cause Becker muscular dystrophy. We did not obtain evidence for alternative splicing or for RNA editing. Immunocytochemical analysis of skeletal muscle showed that a dystrophin-related polypeptide was detectable with antibody directed against the carboxyl-terminal part of the polypeptide but not with antibodies directed against the amino-terminal part, although labeling by antibody against the carboxyl-terminal was faint and patchy. The severity of the disease in this case may be due to the lack of the amino-terminal, actin-binding domain of dystrophin.
Mobil identifies extended-reach-drilling advantages, possibilities in North Sea (1986)

Extended reach drilling (ERD) is an integrated methodology for drilling high-angle well bores with long horizontal displacements. Because long-term profitability is a primary concern of the oil and gas industry, major efforts are under way to optimize drilling procedures to make operations more cost effect. All phases of drilling are being subjected to close scrutiny of the involved economics. Now emerging is the possibility of obtaining substantial savings by upgrading conventional directional drilling techniques into advanced procedures for drilling high-angle, extended-reach well bores. Such a capability offers a variety of applications with the potential for significant reductions in cost. Utilization of ERD procedures could be made to: Develop offshore reservoirs now considered uneconomical; Drill under shipping lanes or under environmentally sensitive areas; Accelerate production by drilling long sections of nearly horizontal hole in producing formations; Provide an alternative for some subsea completions; Reduce the number of platforms necessary to develop a large reservoir.
Antifungal activity of ajoene derived from garlic (1987)

The antifungal activity of six fractions derived from garlic was investigated in an in vitro system. Ajoene had the strongest activity in these fractions. The growth of both Aspergillus niger and Candida albicans was inhibited by ajoene at less than 20 micrograms/ml.
False negative rates in Drosophila cell-based RNAi screens: a case study (2011)

RNAi reagents that target the same gene do not always yield consistent results due to false positives and weak or ineffective reagents. False positive results can be partially minimized by filtering with transcriptome data. RNAi libraries with multiple reagents per gene also reduce false positive and false negative outcomes when inconsistent results are disambiguated carefully.
Parenteral Nutrition Product Shortages (2012)

Product (drug) shortages have had a significant impact on the healthcare system, particularly on patients and clinicians. This has been especially true with patients requiring parenteral nutrition (PN). The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) has dealt with PN product shortages in the past on behalf of its members and their patients. However, the shortage severity and duration have made dealing with the PN product shortages in 2010-2012 extremely challenging.
High-frequency regeneration of base-band vocoders by multi-pulse excitation (2005)

In this paper, we propose a new method for the regeneration of the high-frequency band in base-band vocoders. This approach takes advantage of the quasi-harmonic structure of voiced speech in the time domain, while existing techniques capitalize on this structure in the frequency domain (squaring, full wave rectifying, interpolation, etc ...). We show that the high frequency part of the excitation signal, which is usually regenerated by a frequency duplication of the harmonic structure of the base-band, always presents time variations which can be modeled by a pulse/noise combination. The position and amplitudes of the pulses are shown to be critical for the good reconstruction of the speech wave-form, in the sense that a slight jitter can produce an audible roughness. We report simulation results on a complete vocoder implemented at 7.2 kbps.
The Cytoplasmic Tail Slows the Folding of Human Immunodeficiency Virus Type 1 Env from a Late Prebundle Configuration into the Six-Helix Bundle (2004)

Effects of the cytoplasmic tail (CT) of human immunodeficiency virus type 1 Env on the process of membrane fusion were investigated. Full-length Env (wild type [WT]) and Env with its CT truncated (DeltaCT) were expressed on cell surfaces, these cells were fused to target cells, and the inhibition of fusion by peptides that prevent Env from folding into a six-helix bundle conformation was measured. For both X4-tropic and R5-tropic Env proteins, DeltaCT induced faster fusion kinetics than did the WT, and peptides were less effective at inhibiting DeltaCT-induced fusion. We tested the hypothesis that the inhibitory peptides were less effective at inhibiting DeltaCT-induced fusion because DeltaCT folds more quickly into a six-helix bundle. Early and late intermediates of WT- and DeltaCT-induced fusion were captured, and the ability of peptides to block fusion when added at the intermediate stages was quantified. When added at the early intermediate, the peptides were still less effective at inhibiting DeltaCT-induced fusion but they were equally effective at preventing WT- and DeltaCT-induced fusion when added at the late intermediate. We conclude that for both X4-tropic and R5-tropic Env proteins, the CT facilitates conformational changes that allow the trimeric coiled coil of prebundles to become optimally exposed. But once Env does favorably expose its coiled coil to inhibitory peptides, the CT hinders subsequent folding into a six-helix bundle. Because of this facilitation of maximal exposure and hindrance of bundle formation, the coiled coil is optimally exposed for a longer time for WT than for DeltaCT. This accounts for the greater peptide inhibition of WT-induced fusion.
New efficient sulfurizing reagents for the preparation of oligodeoxyribonucleotide phosphorothioate analogues (1995)

A set of new sulfurizing agents representing disulfides of arylsulfonic acids has been developed for the automated synthesis of phosphorothioate oligonucleotide analogues via the phosphoramidite method. These reagents, such as bis(benzenesulfonyl)disulfide, bis(p-toluenesulfonyl)disulfide, bis(p-methoxybenzensulfonyl)disulfide, and bis (p-chlorobenzenesulfonyl) disulfide, are easily prepared crystalline solid compounds. They are relatively inexpensive, easy to handle, and efficiently convert internucleotide cyanoethyl phosphite to the phosphorothioate triester within 1-2 min. The efficiency of phosphorothioate oligonucleotide synthesis with the use of these reagents is comparable to that of phosphodiester oligonucleotides.
Identification and characterization of Cu2O‐ and ZnO‐binding polypeptides by Escherichia coli cell surface display: toward an understanding of metal oxide binding (2004)

We have used the FliTrx cell surface display system to identify disulfide-constrained dodecapeptides binding to the semiconducting metal oxides Cu(2)O and ZnO. Sequence analysis of the inserts revealed that the two populations exhibit similar, yet subtly different patterns of amino acid usage. Both sets of binders were enriched in arginine, tryptophan, and glycine with a higher degree of positional preference in the case of Cu(2)O binders. Tyrosine, proline, and serine were underrepresented in both populations. Peptides binding electrodeposited Cu(2)O or ZnO with high avidity could be subdivided into two classes based on pI and hydrophilicity. In the hydrophilic and positively charged Class I binders, the Arg-X-X-Arg tetrapeptide appears to be implicated in metal oxide binding, whereas Arg-Arg and Arg-Lys pairs allow for discrimination between Cu(2)O and ZnO. Molecular dynamics simulations of the disulfide-constrained peptides suggest that the aforementioned motifs are important to properly orient two basic residues that are likely to contact the metal oxides. The implications of our results in understanding the rules governing the interaction between peptides and inorganic compounds and in their use for the design of hybrid nanoarchitectures are discussed.
γ-Secretase Catalyzes Sequential Cleavages of the AβPP Transmembrane Domain (2009)

The biogenesis of the amyloid-beta peptide (Abeta) is a central issue in Alzheimer's disease (AD) research. Abeta is produced by beta- and gamma-secretases from the amyloid-beta protein precursor (AbetaPP). These proteases are targets for the development of therapeutic compounds to downregulate Abeta production. gamma-secretase has received more attention 1) because it generates the C-terminus of Abeta, which is important in the pathogenesis of AD because the longer Abeta species are more amyloidogenic, and 2) because it cleaves AbetaPP within its transmembrane domain. In the understanding the mechanism of gamma-secretase cleavage, three major cleavage sites have been identified, namely, gamma-cleavage site at Abeta(40/42), zeta-cleavage site at Abeta(46), and epsilon-cleavage site at Abeta(49). Moreover, the novel finding that some of the known gamma-secretase inhibitors inhibit the formation of secreted Abeta(40) and Abeta(42), but cause an intracellular accumulation of long Abeta(46), provided information extremely important for the development of strategies aimed at the design of gamma-secretase inhibitors to prevent and treat AD. In addition, it has been established that the C-terminus of Abeta is generated by a series of sequential cleavages: first, epsilon-cleavage, followed by zeta-cleavage and finally by gamma-cleavage, commencing from the membrane boundary to the middle of the AbetaPP membrane domain.
Treatment of Peptic Ulcer with Gastric Mucin. (1930)

In the literature on gastric secretion, the capacity of mucus to lower the free acid in the stomach is repeatedly suggested. While working on the “Relationship between Gastric Secretion and Basal Secretion of the Stomach” Lim determined that the concentration of the mucus in the stomach is highest at the lower secretion rates. The problem here was to determine the effect of increasing the mucus content of the stomach upon the free HCl. To evaluate the antacid effect of gastric mucin, it was necessary to either stimulate the secretion of mucin or to administer mucin by mouth. In these experiments attempts at stimulation failed to give consistent results, therefore a neutral preparation of hog mucin was prepared. Two ounces of this mucin in the stomach of Pavlov pouch dogs, after stimulation with 1 mgm. of histamine, was found sufficient to keep the stomach free of free HCl despite the fact that the pouches in these dogs showed adequate gastric secretion. Free HCl would always be present if the same experim...
S-centered radicals (1999)

Structures of Sulphur - Centered Radicals (D. Armstrong & D. Chipman). Thermochemistry of Sulfur Radicals (D. Armstrong). SOx Radical Monoanions - Reactions in Solution and in the Gas Phase (R. Huie & L. Sieck). The Chemistry of Gas Phase Organic Sulfur - Centered Radicals (S. Urbanski & P. Wine). Sulfur Centered Reactive Intermediates as Studied by Radiation Chemical and Complementary Techniques (K. Asmus & M. Bonifacic). Reactions of Aromatic Thiyl Radicals (O. Ito). Reactions of Thiyl Radicals in the Solid Phase (Y. Razskazovskii & M. Mel'nikov). The Sulfoxyl Radicals: Formation, Structure and Kinetics (Y. Razskazovskii, et al.). Organic Sulfuranyl Radicals (P. Margeretha). Thiyl Radicals in Biology: Their Role as a Molecular Switch Central to Cellular Oxidative Stress (P. Wardman). Sulfur Centered Radicals in Organic Synthesis (C. Chatgilialoglu, et al.).
X-linked inhibitor regulating TRAIL-induced apoptosis in chemoresistant human primary glioblastoma cells. (2003)

These results support the use of selective or tailored therapeutic strategies that synergistically sensitize chemoresistant glioblastoma to TRAIL-mediated apoptosis by administering appropriate XIAP downregulating agents.
A major human immunodeficiency virus type 1-initiated killing pathway distinct from apoptosis (1997)

We have investigated the relative contribution of apoptosis or programmed cell death (PCD) to cell killing during acute infection with T-cell-tropic, cytopathic human immunodeficiency virus type 1 (HIV-1), by employing diverse strategies to inhibit PCD or to detect its common end-stage sequelae. When Bcl-2-transfected cell lines were infected with HIV-1, their viability was only slightly higher than that of control infections. Although the adenovirus E1B 19-kDa protein has been reported to be a stronger competitor of apoptosis than Bcl-2, it did not inhibit HIV-mediated cell death better than Bcl-2 protein. Competition for Fas ligand or inactivation of the Fas pathway secondary to intracellular mutation (MOLT-4 T cells) also had modest effects on overall cell death during acute HIV infection. In contrast to these observations with HIV infection or with HIV envelope-initiated cell death, Tat-expressing cell lines were much more susceptible (200% enhancement) to Fas-induced apoptosis than controls and Bcl-2 overexpression strongly (75%) inhibited this apoptotic T-cell death. PCD associated with FasR ligation resulted in the cleavage of common interleukin-1beta-converting enzyme (ICE)-protease targets, poly(ADP-ribose) polymerase (PARP) and pro-ICE, whereas cleaved products were not readily detected during HIV infection of peripheral blood mononuclear cells or T-cell lines even during periods of extensive cell death. These results indicate that one important form of HIV-mediated cell killing proceeds by a pathway that lacks the characteristics of T-cell apoptosis. Our observations support the conclusion that at least two HIV genes (env and tat) can kill T cells by distinct pathways and that an envelope-initiated process of T-cell death can be discriminated from apoptosis by many of the properties most closely associated with apoptotic cell death.