gebhart/patrepeval huggingface dataset:
REVISIÓN SISTEMATICA EN BUSCA DE UN PROCEDIMIENTO PARA LA VALORACIÓN ENFERMERA DE LA NEUROPATÍA PERIFÉRICA DIABÉTICA: SEGUNDA FASE DEL ESTUDIO "NEUDIACAN®". (2018)

Resumen: La neuropatía periférica diabética (NPD) es una de las complicaciones más comunes y problemáticas de la diabetes mellitus puesto que supone la principal causa de úlceras y amputaciones en miembros inferiores. Como resultado de la primera fase del estudio NEUDIACAN® no se detectó ningún procedimiento validado para la valoración de la NPD entre los profesionales sanitarios de Atención Primaria del Servicio Canario de la Salud. Por ello, se procedió a realizar una búsqueda en la literatura científica de algún sistema de valoración, con el fin de encontrar algún instrumento como una escala, test, procedimiento o protocolo que estuviera validado para uso enfermero y que cumpliera características que le permitiese ser aplicado en el ámbito de la atención primaria para prevenir la aparición de complicaciones como el pie diabético.
The Electrophoretic α; 1 -Globulin Pattern of Serum in α; 1 -Antitrypsin Deficiency (1963)

(1963). The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency. Scandinavian Journal of Clinical and Laboratory Investigation: Vol. 15, No. 2, pp. 132-140.
Glomectomy in carotid sinus syncope and associated arrythmias: symptomatic bradycardia, atrial flutter and atrial fibrillation. (2006)

We conclude that our data support the efficiency of G in pts with NMS (either cardioinhibitor or vasodepressor), as well as in related arrhythmias. PM is indicated in pts with associated diseases: intrinsic SSS, AV block, atrial fibrillation with bradycardia.
From embryonal carcinoma cells to neurons: The P19 pathway (1994)

The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct-3 and Brn-2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation.
Semidominant Soybean Mutation for Resistance to Sulfonylurea Herbicides (1989)

A soybean [ Glycine max (L.) Merr. I mutation conferring resistance to a wide range of sulfonylurea (SU) herbicides would greatly enhance the weed control options available to soybean farmers. This report describes the selection, characterization, and potential utility of such mutants. Seed mutagenesis (using N‐nitroso‐N‐methylurea and ethyl methanesulfonate) followed by selection for resistance to chlorsulfuron [2‐chloro‐N‐[(4‐methoxy‐6‐methyl‐l,3,5‐triazin‐2‐yl)aminocarbonyl] benzenesulfonamide] yielded a soybean mutant with a high degree of resistance to both postemergence and pre‐emergence applications of a variety of SU herbicides. Resistance was monogenic, semidominant, and not allelic to any of the previously identified recessive genes hs1 , hs2 , or hs3 that confer tolerance to SU herbicides. Biochemical tests indicate that the mechanism of resistance is reduced sensitivity of acetolactate synthase to SU inhibition. The SU resistance afforded by this mutation (designated Alsl ) can be used to enhance soybean weed control options and can serve as a selectable marker for seed purification.
Crystal Structure of Fucose-Specific Lectin from Aleuria aurantia Binding Ligands at Three of Its Five Sugar Recognition Sites, (2003)

Aleuria aurantia possesses a fucose-specific lectin (AAL) that is widely used as a specific probe for fucose. Fucosylated sugars often play pivotal roles in many cellular processes. We have determined the crystal structure of AAL at 2.24 A resolution in complex with only three fucose molecules in its five sugar binding sites of a six-fold beta-propeller structure. Very recently, the structure of AAL has been independently determined, showing that all the five binding sites were occupied by fucose molecules [Wimmerova, M., et al. (2003) J. Biol. Chem. 278, 27059-27067]. Stabilization of the arginine conformation bound to fucose molecules plays an essential role in generating the difference in the affinity in the five binding sites. Binding models with a couple of saccharides based on biochemical assays suggest that hydrophobic contacts also play important roles in AAL recognizing its ligand.
Self-Control Demands (2015)

Recent theoretical developments and findings in basic research suggest self-control demands (SCDs) to be a unique job stressor. A series of studies in different work settings have corroborated this view. The results show that different forms of SCDs (impulse control, resisting distractions, overcoming inner resistances) (a) contribute significant portions of unique variance to the prediction of various measures of job strain, (b) mutually strengthen each other in their effects on strain, and (c) interact with other forms of SCDs. Furthermore, the relation of SCDs to strain is moderated by various resources like job control, affective organizational commitment, and self-control capacity. Finally, SCDs mediate the relationship between workload and strain.
Anatomy of the Anterior Sacroiliac Joint With Reference to Lumbosacral Nerves (2000)

There are no detailed descriptions of the neural structures that may be seen during surgical interventions of the pelvis. Anatomic dissections were performed to see which nerves are endangered in approaches to the anterior sacroiliac joint for plate fixations. Sixty cadavers were dissected bilaterally. Fifty-one were male and nine were female. L4 and L5 nerve roots were followed along the sacroiliac joint from the intervertebral foramen to the entrance into the lesser pelvis. Measurements were made between the nerves and sacroiliac joint from the proximal end of the joint to the pelvic brim. The L4 nerve root and the lumbosacral trunk (and not the L5 nerve root) were the nerves most susceptible to injury because of their course and proximity to the sacroiliac joint. As a result, during the anterior approach and fixation of the sacroiliac joint with plates, extreme care should be taken to identify the L4 nerve root or lumbosacral trunk or both at the anteroinferior third of the joint because the distance between the nerve and the joint is less than 1 cm.
Studies on Polynucleotides. XXV.1 The Stepwise Synthesis of Specific Deoxyribopolynucleotides (5).1 Further Studies on the Synthesis of Internucleotide Bond by the Carbodiimide Method. The Synthesis of Suitably Protected Dinucleotides as Intermediates in the Synthesis of Higher Oligonucleotides3 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Polynucleotides. XXV.1The Stepwise Synthesis of Specific Deoxyribopolynucleotides (5).1Further Studies on the Synthesis of Internucleotide Bond by the Carbodiimide Method. The Synthesis of Suitably Protected Dinucleotides as Intermediates in the Synthesis of Higher Oligonucleotides3H. Schaller and H. G. KhoranaCite this: J. Am. Chem. Soc. 1963, 85, 23, 3828–3835Publication Date (Print):December 1, 1963Publication History Published online1 May 2002Published inissue 1 December 1963https://pubs.acs.org/doi/10.1021/ja00906a022https://doi.org/10.1021/ja00906a022research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Solid phase synthesis of oligodeoxyribonucleoside phosphorodithioates from thiophosphoramidites (1991)

Oligonucleoside phosphorodithioates 1 are modified DNA sequences with potential use as antisense oligonucleotides. The preparation of up to 20-mers containing all four bases by solid phase synthesis is described, with details on the preparation of the four monomer units (protected nucleoside thiophosphoramidites 2), the conditions used for the assembly of the strands with up to 19 phosphorodithioate linkages, and the purification and characterisation of the products. Full-length homogeneity of HPLC-purified all-phosphorodithioate products is demonstrated by PAGE, but 31P NMR discloses the presence of phosphorothioate impurities (typically 8-9%), the origin of which is discussed. Oligonucleoside phosphorodithioates are freely soluble in water at neutral or basic pH, and are very stable towards oxidation, hydrolysis, and nuclease cleavage. Their ability to hybridize to complementary DNA has been studied by UV melting point (Tm) measurements. The observed depression of Tm, 0.5-2 degrees C per phosphorodithioate linkage, is higher that the 0.4-0.6 degrees C found for phosphorothioates.
An Efficient Synthesis of Substituted 3(4)-Nitropyrroles from Nitroalkenes and Tosylmethyl Isocyanides (1996)

A series of 3(4)-nitropyrroles with alkenyl substituents in the 2- and 3-positions (or 3-position only) is synthesized efficiently in one operation by a base-induced addition of tosylmethyl isocyanide (TosMIC), or unsaturated homologs of TosMIC, to nitroalkenes.
Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y 12 Antagonist, With Clopidogrel in Percutaneous Coronary Intervention (2005)

In this phase 2 study, which was designed to assess safety when administered at the time of percutaneous coronary intervention, prasugrel and clopidogrel both resulted in low rates of bleeding. The results of this trial serve as a foundation for the large phase 3 clinical trial designed to assess both efficacy and safety.
Present and Future Role of Chemical Mechanical Polishing in Wafer Bonding (1998)

Almost all direct wafer bonding has been conducted between chemical-mechanically polished substrates or between thin films that were present on top of the polished substrates. Introducing chemical mechanical polishing in the wafer bonding will make a large range of materials suitable for direct wafer bonding, which has found and will find more, applications in integrated circuits, integrated optics, sensors and actuators, and microelectromechanical systems.
Challenges of WiFi-Enabled and Solar-Powered Sensors for Smart Ports (2016)

Increasing shipment volumes in the space-limited Hamburg port area demand a more efficient way of port organization. To achieve this goal, a key aspect of Hamburg's smart port initiative is to deploy wireless sensors and actuators to realize a cyber-physical port. However, the required large number of sensor and actuator devices raises two essential challenges. Firstly, external power provision infrastructure would be non-economic, inflexible, and therefore infeasible. Secondly, connecting common cyber-physical system devices to the Internet requires additional infrastructure and thus complexity due to the need for gateways. Our research tackles these challenges by investigating the applicability of novel, low-power IEEE802.11 WiFi-based devices to enable communication with existing or planned WiFi access points while being reliably and autarkicly powered by solar power. As a first step, we analyzed the power consumption of a low-power IEEE802.11 WiFi platform. Our measurements show promising results that allow us to propose methods for energy conservation and dimensioning of a miniature solar power supply.
Expression of Laminin α3, α4, and α5 Chains by Alveolar Epithelial Cells and Fibroblasts (1998)

Laminins are principal components of basement membranes. Eleven laminin isoforms are known, each a heterotrimer composed of polypeptide chains designated alpha, beta, and gamma. Five alpha chains have been identified to date: alpha1, alpha2, alpha3, alpha4, and alpha5. Recent studies of fetal and adult mouse lung show prominence of alpha3, alpha4, and alpha5 in alveolar tissue, and point to differences in the cellular expression of these alpha chains in the developing alveolus. We examined isolated rat alveolar type II cells and lung fibroblasts for expression of laminins alpha3, alpha4, and alpha5. We found that laminin alpha3 was expressed only by alveolar epithelial cells, that laminin alpha4 was expressed only by lung fibroblasts, and that laminin alpha5 was expressed primarily by alveolar epithelial cells. Metabolic labeling and immunoprecipitation confirmed the production of laminin alpha4 by fibroblasts and laminin alpha5 by alveolar epithelial cells in culture. These studies indicate that different alveolar cell types contribute different laminin alpha chains to the laminin isoforms in alveolar basement membranes. Immunohistochemistry showed colocalization of these laminin alpha chains with the laminin beta1, beta2, and gamma1 chains, indicating the likelihood that laminins 6 to 11 are present in alveolar basement membranes.
Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells (2008)

High lactate generation and low glucose oxidation, despite normal oxygen conditions, are commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this altered metabolic phenotype has long been correlated with malignant progression and poor clinical outcome. However, the mechanistic relationship between altered glucose metabolism and malignancy remains poorly understood. Here we show that inhibition of pyruvate dehydrogenase complex (PDC) activity contributes to the Warburg metabolic and malignant phenotype in human head and neck squamous cell carcinoma. PDC inhibition occurs via enhanced expression of pyruvate dehydrogenase kinase-1 (PDK-1), which results in inhibitory phosphorylation of the pyruvate dehydrogenase alpha (PDHalpha) subunit. We also demonstrate that PDC inhibition in cancer cells is associated with normoxic stabilization of the malignancy-promoting transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha) by glycolytic metabolites. Knockdown of PDK-1 via short hairpin RNA lowers PDHalpha phosphorylation, restores PDC activity, reverts the Warburg metabolic phenotype, decreases normoxic HIF-1alpha expression, lowers hypoxic cell survival, decreases invasiveness, and inhibits tumor growth. PDK-1 is an HIF-1-regulated gene, and these data suggest that the buildup of glycolytic metabolites, resulting from high PDK-1 expression, may in turn promote HIF-1 activation, thus sustaining a feed-forward loop for malignant progression. In addition to providing anabolic support for cancer cells, altered fuel metabolism thus supports a malignant phenotype. Correction of metabolic abnormalities offers unique opportunities for cancer treatment and may potentially synergize with other cancer therapies.
Low noise reversible MDCT (RMDCT) and its application in progressive-to-lossless embedded audio coding (2005)

A reversible transform converts an integer input to an integer output, while retaining the ability to reconstruct the exact input from the output sequence. It is one of the key components for lossless and progressive-to-lossless audio codecs. In this work, we investigate the desired characteristics of a high-performance reversible transform. Specifically, we show that the smaller the quantization noise of the reversible modified discrete cosine transform (RMDCT), the better the compression performance of the lossless and progressive-to-lossless codec that utilizes the transform. Armed with this knowledge, we develop a number of RMDCT solutions. The first RMDCT solution is implemented by turning every rotation module of a float MDCT (FMDCT) into a reversible rotation, which uses multiple factorizations to further reduce the quantization noise. The second and third solutions use the matrix lifting to implement a reversible fast Fourier transform (FFT) and a reversible fractional-shifted FFT, respectively, which are further combined with the reversible rotations to form the RMDCT. With the matrix lifting, we can design the RMDCT that has less quantization noise and can still be computed efficiently. A progressive-to-lossless embedded audio codec (PLEAC) employing the RMDCT is implemented with superior results for both lossless and lossy audio compression.
Adenovirus Methods and Protocols (1998)

In Adenovirus Methods and Protocols, William S.M. Wold has organized a collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems and for the adenovirus-mediated transformation of cells to a malignant state. Each method is written by a prominent investigator well-versed in the technique and includes a brief background discussion, as well as tried and true step-by-step instructions. Adenovirus Methods and Protocols will be useful to both entry-level and senior scientists seeking to enter the adenovirus field, to researchers from other areas wishing to construct adenovirus vectors for their own research, and to adenovirologists wanting to enter new sectors of research. Its cutting-edge techniques are certain to make it today's reference of choice, one from which even expert researchers will learn many productive and time-saving techniques
The expression of human beta2 microglobulin on human spermatozoa (1976)

The expression of human beta2-microglobulin was detected on human spermatozoa from 7 donors using a cytotoxicity assay and indirect immunofluorescence. Inhibition experiments using purified beta2-microglobulin demonstrated the specificities of these reactions. We were able to localize beta2-microglobulin on human spermatozoa on the post-acrosomal region at a similar location to those described for HL-A antigen and for early embryonic antigen +t12, but also at the end of the intermediary piece and the beginning of the tail.
Depth of Field in Plenoptic Cameras (2009)

Certain new algorithms used by plenoptic cameras require focused microlens images. The range of applicability of these algorithms therefore depends on the depth of field of the relay system comprising the plenoptic camera. We analyze the relationships and tradeoffs between camera parameters and depth of field and characterize conditions for optimal refocusing, stereo, and 3D imaging.
Serotonin in autism and pediatric epilepsies (2004)

Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development--and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This review explores the hypothesis that an early disturbance in the serotonin system affects cortical development and the development of thalamocortical innervation, and is a potential mechanism, common to autism and pediatric epilepsies associated with cortical dysplasia. An argument is made that cortical malformation leads to abnormalities of thalamocortical connectivity, and that serotonin plays a critical role in this process. Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed.
Differential Binding of IgG and IgA to Mucus of the Female Reproductive Tract (2013)

Cells of the endocervix are responsible for the secretion of mucins, which provide an additional layer of protection to the female reproductive tract (FRT). This barrier is likely fortified with IgA as has previously been shown in the gastrointestinal tract and lungs of mice. Mucus associated IgA can facilitate clearance of bacteria. While a similar function for IgG has been proposed, an association with mucus has not yet been demonstrated. Here we find that IgA and IgG are differentially associated with the different types of mucus of the FRT. We observed that while both IgA and IgG are stably associated with cervical mucus, only IgG is associated with cervicovaginal mucus. These findings reveal that antibodies can bind tightly to mucus, where they can play a significant role in the fortification of the mucus barriers of the FRT. It may be possible to harness this interaction in the development of vaccines designed to protect the FRT mucosal barriers from sexually transmitted diseases such as HIV.
A noisy-channel approach to contextual advertising (2007)

Contextual advertising is a growing category of search advertising. It presents a particular challenge to ad placement systems because of the sparseness of the language of advertising. We present a system that is language independent and knowledge free based on SVM ranking. We evaluate it on a large number of advertisements appearing on real Web pages. Our contribution is two new classes of features of similarity between ads and Web pages based on machine translation technologies. We show that our features significantly improve performance over baseline techniques.
Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. (1996)

The terminal differentiation of myelinating glia involves complex interactions that culminate in the formation of myelin. The POU domain transcription factor Tst-1/Oct-6/SCIP is expressed transiently during myelination, and we report here that it has a critical role in this developmental process. Deletion of the Tst-1/Oct-6/SCIP gene produces a severe defect in peripheral myelination by arresting Schwann cell maturation before axonal wrapping. Unexpectedly, the activation of major myelin-specific genes appears to be unaffected by the Tst-1/Oct-6/SCIP mutation, demonstrating that multiple, independently regulated events are required for terminal differentiation of Schwann cells. In addition, aberrant differentiation and migration of specific neurons in Tst-1/Oct-6/SCIP mutant homozygotes is associated with a fatal breathing defect, providing a model for investigating the regulation of pulmonary homeostasis.