gebhart/patrepeval huggingface dataset:
Color Correction in Color Printing1 (1948)

In a three-color print, the color of any area that is large in comparison with the size of the dots of the structured image can be regarded as an additive mixture of eight colors: the unprinted paper stock; the cyan, magenta, and yellow of the individual ink dots; the red, green, and blue that result when ink dots overlap in pairs; and the black that results when all three ink dots overlap. Since the extent of overlapping is determined by the sizes of the dots, the color of the additive mixture can be expressed by three equations. The straightforward attack on the problem of color reproduction is to solve these fundamental equations for the required dot sizes on the assumption that, in every area, the tristimulus values of the reproduction should be equal to those of the original. This has not been accomplished hitherto, because it involves solving three simultaneous equations of third degree, each containing eight terms. However, a relatively simple electronic equation-solving network has been constructed which solves these equations with ample precision in 0.001 second. By using this network in connection with a scanning machine of the type described in the preceding paper, full color correction is achieved. A corresponding set of equations can be written for the additive mixture produced in four-color printing, wherein the fourth color is black. Since the three equations now contain four unknowns, an additional condition must be imposed. From the standpoint of the printing requirements, it is desirable that at least one of the color dots be absent, or of some predetermined minimal size, in every region of the reproduction. An extension of the principles embodied in the electronic network mentioned above imposes this condition and yields a continuous solution to the three fourth-degree equations.
Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment (2020)

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the resident pancreas parenchymal cell repair program. Many solid tumor types including pancreatic cancer have severe tumor fibrosis called desmoplasia. Desmoplastic stroma is coopted by the tumor as a support structure and CAFs aid in tumor growth, invasion, and metastases. This stroma is caused by cancer associated fibroblasts (CAFs), which lay down extensive connective tissue in and around the tumor cells. CAFs represent a heterogeneous population of cells that produce various paracrine molecules such as transforming growth factor-beta (TGF-beta) and platelet derived growth factors (PDGFs) that aid tumor growth, local invasion, and development of metastases. The hard, fibrotic shell of desmoplasia serves as a barrier to the infiltration of both chemo- and immunotherapy drugs and host immune cells to the tumor. Although there have been recent improvements in chemotherapy and surgical techniques for management of pancreatic cancer, the majority of patients will die from this disease. Therefore, new treatment strategies are clearly needed. CAFs represent an under-explored potential therapeutic target. This paper discusses what we know about the role of CAFs in pancreatic cancer cell growth, invasion, and metastases. Additionally, we present different strategies that are being and could be explored as anti-CAF treatments for pancreatic cancer.
Bidirectional recurrent neural networks (1997)

In the first part of this paper, a regular recurrent neural network (RNN) is extended to a bidirectional recurrent neural network (BRNN). The BRNN can be trained without the limitation of using input information just up to a preset future frame. This is accomplished by training it simultaneously in positive and negative time direction. Structure and training procedure of the proposed network are explained. In regression and classification experiments on artificial data, the proposed structure gives better results than other approaches. For real data, classification experiments for phonemes from the TIMIT database show the same tendency. In the second part of this paper, it is shown how the proposed bidirectional structure can be easily modified to allow efficient estimation of the conditional posterior probability of complete symbol sequences without making any explicit assumption about the shape of the distribution. For this part, experiments on real data are reported.
Uncovering the true cost of hydrogen production routes using life cycle monetisation (2020)

Hydrogen has been identified as a potential energy vector to decarbonise the transport and chemical sectors and achieve global greenhouse gas reduction targets. Despite ongoing efforts, hydrogen technologies are often assessed focusing on their global warming potential while overlooking other impacts, or at most including additional metrics that are not easily interpretable. Herein, a wide range of alternative technologies have been assessed to determine the total cost of hydrogen production by coupling life-cycle assessments with an economic evaluation of the environmental externalities of production. By including monetised values of environmental impacts on human health, ecosystem quality, and resources on top of the levelised cost of hydrogen production, an estimation of the “real” total cost of hydrogen was obtained to transparently rank the alternative technologies. The study herein covers steam methane reforming (SMR), coal and biomass gasification, methane pyrolysis, and electrolysis from renewable and nuclear technologies. Monetised externalities are found to represent a significant percentage of the total cost, ultimately altering the standard ranking of technologies. SMR coupled with carbon capture and storage emerges as the cheapest option, followed by methane pyrolysis, and water electrolysis from wind and nuclear. The obtained results identify the “real” ranges for the cost of hydrogen compared to SMR (business as usual) by including environmental externalities, thereby helping to pinpoint critical barriers for emerging and competing technologies to SMR.
Depth Intra Coding for 3D Video Based on Geometric Primitives (2015)

This paper presents an advanced depth intra-coding approach for 3D video coding based on the High Efficiency Video Coding (HEVC) standard and the multiview video plus depth (MVD) representation. This paper is motivated by the fact that depth signals have specific characteristics that differ from those of natural signals, i.e., camera-view video. Our approach replaces conventional intra-picture coding for the depth component, targeting a consistent and efficient support of 3D video applications that utilize depth maps or polygon meshes or both, with a high depth coding efficiency in terms of minimal artifacts in rendered views and meshes with a minimal number of triangles for a given bit rate. For this purpose, we introduce intra-picture prediction modes based on geometric primitives along with a residual coding method in the spatial domain, substituting conventional intra-prediction modes and transform coding, respectively. The results show that our solution achieves the same quality of rendered or synthesized views with about the same bit rate as MVD coding with the 3D video extension of HEVC (3D-HEVC) for high-quality depth maps and with about 8% less overall bit rate as with 3D-HEVC without related depth tools. At the same time, the combination of 3D video with 3D computer graphics content is substantially simplified, as the geometry-based depth intra signals can be represented as a surface mesh with about 85% less triangles, generated directly in the decoding process as an alternative decoder output.
Courteous glass (2014)

Small and always-on, wearable video cameras disrupt social norms that have been established for traditional hand-held video cameras, which explicitly signal when and which subjects are being recorded to people around the camera-holder. We first discuss privacy-related social cues that people employ when recording other people (as a camera-holder) or when being recorded by others (as a bystander or a subject). We then discuss how low-fidelity sensors such as far-infrared imagers can be used to capture these social cues and to control video cameras accordingly in order to respect the privacy of others. We present a few initial steps toward implementing a fully functioning wearable camera that recognizes social cues related to video privacy and generates signals that can be used by others to adjust their privacy expectations.
Formic Acid Catalysed Rearrangement of 5?-Methyldihydrothevinols (=3,6-Dimethoxy-5,17-dimethyl-4,5-epoxy-6,14-ethanomorphinan-7-methanols): Synthesis of New Doubly Bridged Morphinan Derivatives (2005)

We recently showed that substitution of a 5beta-methyl group allows the isolation of 14-alkenyldihydrocodeinones from the action of hot formic acid on certain dihydrothevinols. It has now been shown that, in those dihydrothevinols which are converted to stable side chain olefins by such treatment, introduction of a 5beta-methyl group results in the formation of new doubly bridged morphinan derivatives in addition to the dihydrocodeinones or olefins. The new morphinans have low affinities for opioid receptors.
Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes. (2002)

Great advances have been made in the management of diabetes during the past decade. Whereas only one class of oral medications (the sulfonylureas) was available for the treatment of type 2 diabetes in the early 1990s, we now have five classes of oral antidiabetic agents from which to choose. The thiazolidinedione class of medications was first introduced to the United States when troglitazone was marketed during early 1997. Rosiglitazone, approved by the FDA during the spring of 1999, was the second thiazolidinedione to be marketed in the United States. Similar to troglitazone, rosiglitazone improves insulin sensitivity in patients with type 2 diabetes by activating peroxisome proliferator-activated receptor-gamma (PPARgamma) receptors in adipose tissues, skeletal muscles, and the liver. The efficacy and safety of rosiglitazone therapy in patients with type 2 diabetes have been demonstrated in a number of clinical studies, which are summarized in this article. Selected characteristics of rosiglitazone are compared with those of pioglitazone--the other thiazolidinedione currently available in the United States. Edema of mild to moderate severity has been reported in approximately 5% of patients treated with rosiglitazone during clinical trials. Therefore, caution must be taken when this agent is administered to patients with heart failure. Rosiglitazone has also been associated with elevations of total, LDL, and HDL cholesterol during clinical trials. However, the LDL:HDL cholesterol ratio or the total:HDL cholesterol ratio has mostly been observed to be unchanged. Although liver toxicity has not been observed with rosiglitazone during clinical trials, the safety of this drug for long-term usage and in larger patient populations remains to be established in further clinical studies and in postmarketing experience.
Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts (1996)

A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. The outer membrane (OM) and isolated lipopolysaccharide (LPS) of S. montevideo showed a higher affinity for these cationic peptides than did the corresponding B. abortus OM and LPS. We took advantage of the moderate sensitivity of R B. abortus to cationic peptides to construct live R B. abortus-S-LPS chimeras to test the activities of polymyxin B, lactoferricin B, and EDTA. Homogeneous and abundant peripheral distribution of the heterologous S-LPS was observed on the surface of the chimeras, and this coating had no effect on the viability or morphology of the cells. When the heterologous LPS corresponded to the less sensitive bacterium S B. abortus S19, the chimeras were more resistant to cationic peptides; in contrast, when the S-LPS was from the more sensitive bacterium S. montevideo, the chimeras were more susceptible to the action of peptides and EDTA. A direct correlation between the amount of heterologous S-LPS on the surface of chimeric Brucella cells and peptide sensitivity was observed. Whereas the damage produced by polymyxin B in S. montevideo and B. abortus-S. montevideo S-LPS chimeras was manifested mainly as OM blebbing and inner membrane rolling, lactoferricin B caused inner membrane detachment, vacuolization, and the formation of internal electron-dense granules in these cells. Native S and R B. abortus strains were permeable to the hydrophobic probe N-phenyl-1-naphthylamine (NPN). In contrast, only reduced amounts of NPN partitioned into the OMs of the S. montevideo and B. abortus-S. montevideo S-LPS chimeras. Following peptide exposure, accelerated NPN uptake similar to that observed for S. montevideo was detected for the B. abortus-S. montevideo LPS chimeras. The partition of NPN into native or EDTA-, polymyxin B-, or lactoferricin B-treated LPS micelles of S. montevideo or B. abortus mimicked the effects observed with intact cells, and this was confirmed by using micelle hybrids of B. abortus and S. montevideo LPSs. The results showed that LPS is the main cause of B. abortus' resistance to bactericidal cationic peptides, the OM-disturbing action of divalent cationic chelants, and OM permeability to hydrophobic substances. It is proposed that these three features are related to the ability of Brucella bacteria to multiply within phagocytes.
Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol. (1999)

We found and previously reported a new mammalian DNA polymerase inhibitor from a sea alga, Gigartina tenella, (Ohta K., et al., Chem. Pharm. Bull., 46, 684-686, 1998). It was a new sulfolipid compound that belonged in the class of sulfoquinovosyldiacylglycerol. The biochemical properties have been investigated here. The compound, temporarily designated KM043, potently inhibited the activities of mammalian DNA polymerase alpha(pol. alpha) and DNA polymerase beta(pol. beta) and terminal deoxynucleotidyl transferase (TdT), and moderately, human immunodeficiency virus reverse transcriptase (HIV-RT). KM043 dose-dependently inhibited their activities, and each of their IC50 values was 0.25 microM for pol. alpha, 0.38 microM for TdT, 3.6 microM for pol. beta, or 11.2 microM for HIV-RT, and almost complete inhibition of each was achieved at 1.0 to 2.0 microM for pol. alpha and TdT, 7.5 microM for pol. beta and about 30 microM for HIV-RT. However, the compound did not influence the activities of prokaryotic DNA polymerases such as E. coli DNA polymerase I, and DNA metabolic enzymes like DNase 1. Inhibition of pol. alpha or beta by KM043 was non-competitive with both the DNA template and the substrate deoxythymidine 5'-triphosphate (dTTP). KM043 was weakly cytotoxic to cultured HeLa-S3 cells, and the IC50 value was 80 microM. KM043 could synergistically enhance the cytocidal effect of an anti-cancer chemotherapy agent, bleomycin. In the presence of 50 microM KM043, the effect ratio of (bleomycin plus KM043)/(bleomysin only) decreased from 0.76 to 0.22.
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. (1994)

Transgenic mice were generated by using the alpha-myosin heavy chain promoter coupled to the coding sequence of a constitutively active mutant alpha 1B-adrenergic receptor (AR). These transgenic animals demonstrated cardiac-specific expression of this alpha 1-AR with resultant activation of phospholipase C as shown by increased myocardial diacylglycerol content. A phenotype consistent with cardiac hypertrophy developed in adult transgenic mice with increased heart/body weight ratios, myocyte cross-sectional areas, and ventricular atrial natriuretic factor mRNA levels relative to nontransgenic controls. These transgenic animals may provide insight into the biochemical triggers that induce hypertrophy in cardiac disease and serve as a convenient experimental model for studies of this condition.
Influence of burst TENS stimulation on the healing of Achilles tendon suture in man. (2003)

Retrograde or antidromic stimulation of the nociceptive C fibres is known to lead to the release of sensory neuropeptides Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) by the peripheral endings of these ultra-thin nerve fibres. These neuropeptides have, among others, a vasodilatory effect, which explains why they play a role in the healing of soft tissues. Burst TENS (Transcutaneous Electric Nerve Stimulation) is known to be most effective in influencing C fibre-evoked activity. This is why burst TENS was used in a randomised study as a stimulus for the healing of the sutured Achilles tendon in 10 patients, versus 10 others who received no stimulus. There was one drop-out in each group, so that 2 x 9 patients remained available for the study. A needle biopsy, performed after six weeks, showed no significant influence of burst TENS on the histological healing stage, as compared with a rat study. However, a semi-quantitative evaluation of the number of fibroblasts showed a significant advantage for the stimulated group: p = 0.007. This means that burst TENS might influence healing of Achilles tendon sutures in man. But above all, it means that a histochemical study of the influence of burst TENS on the release of substance P and CGRP, after suture of the Achilles tendon in man, would be worthwhile.
Distributed compression of binary sources using conventional parallel and serial concatenated convolutional codes (2003)

It is shown how conventional parallel (turbo) and serial concatenated convolutional codes can be used to compress close to the Slepian-Wolf limit for the correlated binary sources. Conventional refers to codes already used in channel coding. Focusing on the asymmetric case of compression of an equipolarable memoryless binary source with side information at the decoder, the approach is based on modeling the correlation as a channel and using syndromes. The encoding and decoding procedures are explained in detail. The performance achieved is seen to be better than the recently published results using nonconventional turbo codes and close to the Slepian-Wolf limit.
Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural dysfunction (2008)

AVE7688 is an effective treatment for microvascular and neural disease in ZDF rats. Thus, vasopeptidase inhibitors may be an effective treatment for diabetic microvascular and neural complication in type 2 diabetes.
ChemInform Abstract: FREE RADICAL HETEROCYCLIZATION OF ACETYLENIC THIOLS (1981)

Abstract Die photoinduzierte Cyclisierung der Alkinthiole (I) bzw. (V) unter mannigfaltigen Bedingungen liefert über intermediäre Radikale in wechselnden.
Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis (1992)

Hirudin from the leech Hirudo medicinalis is a most powerful anticoagulant, and many isoforms have been described. In the present work, the primary structure of two hirudins from the leech Hirudinaria manillensis has been elucidated. The antithrombotic activity is similar to that of H. medicinalis hirudins although the sequence identity is below 60%. Surprisingly, the hirudins were found to be glycosylated at one site. Sugar analysis after methanolysis yielded fucose, galactose, and N-acetylgalactosamine. These results combined with data from matrix-assisted laser desorption ionization mass spectrometry, plasma desorption mass spectrometry, capillary zone electrophoresis, and lectin-binding tests indicate that the sequence is Fuc-Gal beta 1-3GalNAc-(O-threonine). This structure shows an interesting similarity to human blood group H determinants.
Bacterial cooperation in the wild and in the clinic: Are pathogen social behaviours relevant outside the laboratory? (2012)

Individual bacterial cells can communicate via quorum sensing, cooperate to harvest nutrients from their environment, form multicellular biofilms, compete over resources and even kill one another. When the environment that bacteria inhabit is an animal host, these social behaviours mediate virulence. Over the last decade, much attention has focussed on the ecology, evolution and pathology of bacterial cooperation, and the possibility that it could be exploited or destabilised to treat infections. But how far can we really extrapolate from theoretical predictions and laboratory experiments to make inferences about 'cooperative' behaviours in hosts and reservoirs? To determine the likely importance and evolution of cooperation 'in the wild', several questions must be addressed. A recent paper that reports the dynamics of bacterial cooperation and virulence in a field experiment provides an excellent nucleus for bringing together key empirical and theoretical results which help us to frame - if not completely to answer - these questions.
Mitochondrial Copy Number is Associated with Colorectal Cancer Risk (2012)

The findings of the present study support that mtDNA may play a critical role in the colorectal carcinogenesis in humans.
45nm low power CMOS logic compatible embedded STT MRAM utilizing a reverse-connection 1T/1MTJ cell (2009)

This paper reports a 45 nm spin-transfer-torque (STT) MRAM embedded into a standard CMOS logic platform that employs low-power (LP) transistors and Cu/low-k BEOL. We believe that this is the first-ever demonstration of embedded STT MRAM that is fully compatible with the 45 nm logic technology. To ensure the switching margin, a novel "reverse-connection" 1T/1MT cell has been developed with a cell size of 0.1026 ¿m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This cell is utilized to build embedded memory macros up to 32 Mbits in density. Device attributes and design windows have been examined by considering PVT variations to secure operating margins. Promising early reliability data on endurance, read disturb, and thermal stability have been obtained.