gebhart/patrepeval huggingface dataset:
Collagen-mediated platelet activation and PI3K (2003)

Phosphatidylinositol 3–kinase (PI3K) is a phospholipid kinase that is involved in diverse cellular events, including the prevention of apoptosis, regulation of glucose metabolism, chemotaxis, and cell proliferation. It is far from obvious what role this enzyme would play in a platelet—a
ExPASy: SIB bioinformatics resource portal (2012)

ExPASy (http://www.expasy.org) has worldwide reputation as one of the main bioinformatics resources for proteomics. It has now evolved, becoming an extensible and integrative portal accessing many scientific resources, databases and software tools in different areas of life sciences. Scientists can henceforth access seamlessly a wide range of resources in many different domains, such as proteomics, genomics, phylogeny/evolution, systems biology, population genetics, transcriptomics, etc. The individual resources (databases, web-based and downloadable software tools) are hosted in a 'decentralized' way by different groups of the SIB Swiss Institute of Bioinformatics and partner institutions. Specifically, a single web portal provides a common entry point to a wide range of resources developed and operated by different SIB groups and external institutions. The portal features a search function across 'selected' resources. Additionally, the availability and usage of resources are monitored. The portal is aimed for both expert users and people who are not familiar with a specific domain in life sciences. The new web interface provides, in particular, visual guidance for newcomers to ExPASy.
Successful Treatment of an Angiogenic Disease (1989)

A hypothesis was proposed in the Journal in 1971 that the growth of tumors depends on angiogenesis.1 This concept is now widely accepted because of supporting data from experimental studies and clinical observations carried out over the intervening years.2 These studies led to the discovery of angiogenic polypeptides, the elucidation of their complete amino acid sequences, and the cloning of their genes.2 The angiogenic proteins range in molecular weight from 5500 to 45,000 and can be classified according to their effects on vascular endothelium. Some, such as platelet-derived endothelial-cell growth factor (PD-ECGF),3 are mitogenic, chemotactic, or both in a manner . . .
A Multicenter Risk Index for Atrial Fibrillation After Cardiac Surgery (2004)

We have developed and validated models predicting the occurrence of atrial fibrillation after CABG surgery based on an analysis of a large multicenter international cohort. Our findings suggest that treatment with beta-blockers, ACE inhibitors, and/or nonsteroidal anti-inflammatory drugs may offer protection. Atrial fibrillation after CABG surgery is associated with important complications.
Crystal Structure of Human Tryptophanyl-tRNA Synthetase Catalytic Fragment (2004)

Human tryptophanyl-tRNA synthetase (hTrpRS) produces a full-length and three N terminus-truncated forms through alternative splicing and proteolysis. The shortest fragment that contains the aminoacylation catalytic fragment (T2-hTrpRS) exhibits the most potent angiostatic activity. We report here the crystal structure of T2-hTrpRS at 2.5 A resolution, which was solved using the multi-wavelength anomalous diffraction method. T2-hTrpRS shares a very low sequence homology of 22% with Bacillus stearothermophilus TrpRS (bTrpRS); however, their overall structures are strikingly similar. Structural comparison of T2-hTrpRS with bTrpRS reveals substantial structural differences in the substrate-binding pocket and at the entrance to the pocket that play important roles in substrate binding and tRNA binding. T2-hTrpRS has a wide opening to the active site and adopts a compact conformation similar to the closed conformation of bTrpRS. These results suggest that mammalian and bacterial TrpRSs might use different mechanisms to recognize the substrate. Modeling studies indicate that tRNA binds with the dimeric enzyme and interacts primarily with the connective polypeptide 1 of hTrpRS via its acceptor arm and the alpha-helical domain of hTrpRS via its anticodon loop. Our results also suggest that the angiostatic activity is likely located at the alpha-helical domain, which resembles the short chain cytokines.
Purification of genomic sequences from bacteriophage libraries by recombination and selectionin vivo (1983)

Cloned genes have been purified from recombinant DNA bacteriophage libraries by a method exploiting homologous reciprocal recombination in vivo. In this method 'probe' sequences are inserted in a very small plasmid vector and introduced into recombination-proficient bacterial cells. Genomic bacteriophage libraries are propagated on the cells, and phage bearing sequences homologous to the probe acquire an integrated copy of the plasmid by reciprocal recombination. Phage bearing integrated plasmids can be purified from the larger pool of phage lacking plasmid integrates by growth under the appropriate selective conditions.
GaN Substrates—Progress, Status, and Prospects (2009)

Recent advances in the research, development, and commercial production of native GaN substrates with low defect density and high structural and optical quality have attracted a renewed interest in development of nitride devices based on native substrates. The still low yet rapidly increasing availability of native GaN substrates opens the full potential of GaN devices and has accelerated progress in the development of several electronic and optoelectronic devices. In this paper, progress in the primary competing growth techniques for producing native GaN substrates will be reviewed. The technological issues pertaining to faster scalability of GaN substrate production will be discussed. The current state-of-the-art substrate material properties and the future prospects for the growth approaches and substrate quality will be presented.
Event Processing and Stream Reasoning with ETALIS (2012)

This thesis presents the ETALIS Language for Events (ELE), a declarative rule-based language for Event Processing (EP) and Stream Reasoning (SR). ELE features a well-defined semantics, and provides strong event processing and reasoning capabilities. In this work we present ELE and show how its EP and SR capabilities have the potential to provide powerful real time intelligence. We provide a prototype implementation of the language, and present evaluation results for a few implemented scenarios.
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells (2000)

1. The pharmacological properties of K(ATP) channels generated by stable co-expression of the sulphonylurea receptor SUR1 and the inwardly rectifying K(+) channel Kir6.2 were characterized in HEK-293 cells. 2. [(3)H]-Glyburide (glibenclamide) bound to transfected cells with a B(max) value of 18.5 pmol mg(-1) protein and with a K(D) value of 0.7 nM. Specific binding was displaced by a series of sulphonylurea analogues with rank order potencies consistent with those observed in pancreatic RINm5F insulinoma and in the brain. 3. Functional activity of K(ATP) channels was assessed by whole cell patch clamp, cation efflux and membrane potential measurements. Whole cell currents were detected in transfected cells upon depletion of internal ATP or by exposure to 500 microM diazoxide. The currents showed weak inward rectification and were sensitive to inhibition by glyburide (IC(50)=0.92 nM). 4. Metabolic inhibition by 2-deoxyglucose and oligomycin treatment triggered (86)Rb(+) efflux from transfected cells that was sensitive to inhibition by glyburide (IC(50)=3.6 nM). 5. Diazoxide, but not levcromakalim, evoked concentration-dependen decreases in DiBAC(4)(3) fluorescence responses with an EC(50) value of 14.1 microM which were attenuated by the addition of glyburide. Diazoxide-evoked responses were inhibited by various sulphonylurea analogues with rank order potencies that correlated well with their binding affinities. 6. In summary, results from ligand binding and functional assays demonstrate that the pharmacological properties of SUR1 and Kir6.2 channels co-expressed in HEK-293 cells resemble those typical of native K(ATP) channels described in pancreatic and neuronal tissues.
Melatonin. A Mammalian Pineal Hormone* (1981)

PROBABLY no other organ in the body has suffered so long from a lack of its true functional recognition as the pineal gland. For more than two centuries the pineal was thought to be the seat of the soul or a vestigial remnant of the parietal eye. However, pineal research over the last 20 years has contributed significantly to unraveling the functional significance of this enigmatic endocrine gland. In this respect the isolation and characterization of melatonin by Lerner et al. (1) in 1958 constituted a landmark inasmuch as it was the first substance to be characterized in the pineal gland that reproduced many of the effects of pineal extracts or reversed the endocrine sequelae of pinealectomy. Today the pineal gland is recognized as an active functioning neuroendocrine organ that responds primarily to photic stimuli (and secondarily to hormonal signals originating in target tissues), exhibits circadian rhythms, and influences the metabolic activity of a host of endocrine glands.
On mammary stem cells (2005)

Mammary gland stem cells are a quiescent and self-renewing population within the mammary gland that are capable of giving rise to the differentiated ductal, alveolar and myoepithelial cells. To identify mammary gland stem cells, several investigators have employed a variety of methods including: non-adherent mammosphere cultures; 5-bromo-2-deoxy-uridine (BrdU) label-retention studies; cell-surface markers, such as Sca1 and CD49f; and Hoechst dye efflux. These methods have helped identify and further characterize signal transduction pathways such as the Notch, Wnt and Hedgehog pathways that may be important for the self-renewal and fate determination of mammary gland stem cells. Stem cells within the mammary gland have been proposed to underpin many types of breast cancer. A better understanding of the signal transduction pathways and the molecules that are responsible for the self-renewal and survival of these cells will be essential in the design of more effective therapies aimed at the eradication of both cancer-initiating cells and breast cancer stem cells.
The TREC-2001 Cross-Language Information Retrieval Track: Searching Arabic using English, French or Arabic Queries (2001)

Ten groups participated in the TREC-2001 cross-language information retrieval track, which focussed on retrieving Arabic language documents based on 25 queries that were originally prepared in English. French and Arabic translations of the queries were also available. This was the first year in which a large Arabic test collection was available, so a variety of approaches were tried and a rich set of experiments performed using resources such as machine translation, parallel corpora, several approaches to stemming and/or morphology, and both pre-translation and post-translation blind relevance feedback. On average, forty percent of the relevant documents discovered by a participating team were found by no other team, a higher rate than normally observed at TREC. This raises some concern that the relevance judgment pools may be less complete than has historically been the case.
Characterization of the human receptor for T-cell growth factor. (1983)

Anti-Tac monoclonal antibody has been identified as a putative antibody against the receptor for T-cell growth factor (TCGF). We now show that: (i) TCGF blocks 85% of 3H-labeled anti-Tac binding to phytohemagglutinin-activated lymphoblasts and (ii) both anti-Tac and anti-TCGF immunoprecipitate a protein band that appears to represent TCGF crosslinked to its receptor on HUT-102B2 cells. In HUT-102B2 cells, the TCGF receptor is a Mr 50,000 glycoprotein with internal disulfide bond(s) and a pI of 5.5-6.0, and it represents approximately equal to 0.05% of total cellular de novo protein synthesis. It contains a peptide of Mr 33,000 that is processed to a mature form that includes N-linked and O-linked sugars and sialic acid.
SMS: The Short Message Service (2007)

Although it is a widely used communication mechanism for cell phone users, SMS is far more than just a technology for teenage chat. SMS technology evolved out of the global system for mobile communications standard, an internationally accepted cell phone network specification the European Telecommunications Standards Institute created. The 3rd Generation Partnership Project maintains the SMS standard. SMS messages are handled via a short message service center that the cellular provider maintains for the end devices. The SMSC can send SMS messages to the end device using a maximum payload of 140 octets. This defines the upper bound of an SMS message to be 160 characters using 7-bit encoding. It is possible to specify other schemes such as 8-bit or 16-bit encoding, which decreases the maximum message length to 140 and 70 characters, respectively.
The internet worm program: an analysis (1989)

On the evening of 2 November 1988, someone infected the Internet with a worm program. That program exploited flaws in utility programs in systems based on BSD-derived versions of UNIX. The flaws allowed the program to break into those machines and copy itself, thus infecting those systems. This program eventually spread to thousands of machines, and disrupted normal activities and Internet connectivity for many days.This report gives a detailed description of the components of the worm program---data and functions. It is based on study of two completely independent reverse-compilations of the worm and a version disassembled to VAX assembly language. Almost no source code is given in the paper because of current concerns about the state of the "immune system" of Internet hosts, but the description should be detailed enough to allow the reader to understand the behavior of the program.The paper contains a review of the security flaws exploited by the worm program, and gives some recommendations on how to eliminate or mitigate their future use. The report also includes an analysis of the coding style and methods used by the author(s) of the worm, and draws some conclusions about his abilities and intent.
Effects of an Oral Growth Hormone Secretagogue in Older Adults (2009)

In healthy older adults at risk for functional decline, administration of the oral GHS capromorelin may improve body composition and physical function.
Molecular Analysis of Cellulose Biosynthesis in Arabidopsis (1998)

Cellulose, an abundant, crystalline polysaccharide, is central to plant morphogenesis and to many industries. Chemical and ultrastructural analyses together with map-based cloning indicate that the RSW1 locus of Arabidopsis encodes the catalytic subunit of cellulose synthase. The cloned gene complements the rsw1 mutant whose temperature-sensitive allele is changed in one amino acid. The mutant allele causes a specific reduction in cellulose synthesis, accumulation of noncrystalline beta-1,4-glucan, disassembly of cellulose synthase, and widespread morphological abnormalities. Microfibril crystallization may require proper assembly of the RSW1 gene product into synthase complexes whereas glucan biosynthesis per se does not.
Amino-Linked Ribozymes: Post-Synthetic Conjugation of Half-Ribozymes (1997)

Abstract A convergent approach, based on the reductive amination of 3′-phospho-glycaldehyde-ribozyme 3 with 5′-aminohexyLribozyme 1 generated an amino-linked ribozyme 4 in good yields. Catalytic activity of the cross-linked ribozyme is discussed.
Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase. (2001)

Given the expression of HLA-A2 and HLA-A3 antigen in the general population, these findings extend the potential applicability of hTERT as a therapeutic target to >60% of all cancer patients. The characterization of hTERT as a polyepitope, polyallelic tumor-associated antigen may provide an approach for circumventing therapy-induced resistance potentially mediated by antigenic- and allelic-loss tumor escape mutants.
HUMAN FOLLICLE-STIMULATING HORMONE (1968)

Journal Article HUMAN FOLLICLE-STIMULATING HORMONE Get access PAUL ROOS PAUL ROOS Search for other works by this author on: Oxford Academic Google Scholar Acta Endocrinologica (Norway), Volume 59, Issue 1_Supplement, Dec 1968, Pages S11–S93, https://doi.org/10.1530/acta.0.059S011 Published: 01 December 1968
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism (2005)

Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-dependent signaling. The downstream effectors of this pathway have not been previously defined. In this report, we identify a key target of the LIF self-renewal pathway by showing that STAT3 directly regulates the expression of the Myc transcription factor. Murine ES cells express elevated levels of Myc and following LIF withdrawal, Myc mRNA levels collapse and Myc protein becomes phosphorylated on threonine 58 (T58), triggering its GSK3beta dependent degradation. Maintained expression of stable Myc (T58A) renders self-renewal and maintenance of pluripotency independent of LIF. By contrast, expression of a dominant negative form of Myc antagonizes self-renewal and promotes differentiation. Transcriptional control by STAT3 and suppression of T58 phosphorylation are crucial for regulation of Myc activity in ES cells and therefore in promoting self-renewal. Together, our results establish a mechanism for how LIF and STAT3 regulate ES cell self-renewal and pluripotency.
LNA-antisense rivals siRNA for gene silencing. (2004)

Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing unprecedented binding affinity toward complementary DNA and RNA while obeying the Watson-Crick base-pairing rules. For efficient gene silencing in vitro and in vivo, fully modified or chimeric LNA oligonucleotides have been applied. LNA oligonucleotides are commercially available, can be transfected using standard techniques, are non-toxic, lead to increased target accessibility, can be designed to activate RNase H, and function in steric block approaches. LNA-Antisense, including gapmer LNA containing a central DNA or phosphorothioate-DNA segment flanked by LNA gaps, rivals siRNA as the technology of choice for target validation and therapeutic applications.<br/><br/>
Stypandrol, a Toxic Binaphthalenetetrol Isolated from Stypandra imbricata (1985)

The compound responsible for the toxicity of the plant Stypandra imbricata has been isolated and shown to be 7,7'-diacetyl-6,6'- dimethyl-2,2'-binaphthalene-1,1',8,8'-tetrol (5) by spectroscopic and single-crystal X-ray diffraction methods.
Pharmacological Therapy for Acute Lung Injury (2010)

Many pharmacological therapies have been investigated for use in acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). These therapies can broadly be classified as being either anti-inflammatory or physiology based. Despite promising pre-clinical and small clinical studies almost all therapies have been shown to be unsuccessful in large scale randomized controlled trials. The evidence for pharmacological treatment for ALI/ARDS is reviewed. Potential future treatments are also presented.
Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative information (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative informationDavid M. Haaland and Edward V. ThomasCite this: Anal. Chem. 1988, 60, 11, 1193–1202Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ac00162a020https://doi.org/10.1021/ac00162a020research-articleACS PublicationsRequest reuse permissionsArticle Views5298Altmetric-Citations2001LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Plasticity in Expression of the Glutamate Transporters GLT-1 and GLAST in Spinal Dorsal Horn Glial Cells following Partial Sciatic Nerve Ligation (2009)

These results indicate that the expression of glutamate transporters in astrocytes and microglia are differentially regulated following nerve injury.
Characterization of Escherichia coli serotype O157:H7 (1988)

A total of 174 strains of Escherichia coli serotype O157:H7 representing human isolates obtained from outbreaks and sporadic cases of hemorrhagic colitis, hemolytic-uremic syndrome, and nonbloody diarrheal illnesses as well as from asymptomatic carriers across Canada and the United States were examined. E. coli serotype O157:H7 possessed distinct biochemical markers, a 100% negative reaction for beta-glucuronidase and sorbitol, and a 100% positive reaction for raffinose and dulcitol; all strains otherwise were biochemically typical of E. coli. The vast majority (97%) of the strains were susceptible to commonly used antimicrobial agents. All strains produced readily detectable levels of Verotoxin; however, with polymyxin extraction, nearly 50% of the strains showed up to a 10-fold increase in the toxin level. None were found to mediate hemagglutination of human group A erythrocytes with or without D-mannose. The majority (approximately 70%) of the strains showed localized and diffuse adherence to HEp-2 cells and Henle 407 cells, and the adherence patterns were not very different from those observed among other E. coli strains. Twenty phage types were recognized, with phage types 1 and 2 accounting for 65% of the test strains. Plasmid analysis indicated three basic plasmid profiles: profile I was characterized by 68.7- and 4.2-megadalton (MDa) plasmids (62% of strains), profile II was characterized by 66.2- and 1.8-MDa plasmids (20% of strains), and profile III was characterized by a 62.5-MDa plasmid (18% of strains). A small number (19%) of the strains carried at least one additional plasmid over the basic complements, and these could be considered to constitute a miscellaneous category. None of the above-described characteristics of E. coli serotype O157:H7 could be directly correlated with one another, with the nature of infection, or with the geographical distribution of strains.