gebhart/patrepeval huggingface dataset:
Injectable Electronic Identification, Monitoring, and Stimulation Systems (1999)

Historically, electronic devices such as pacemakers and neuromuscular stimulators have been surgically implanted into animals and humans. A new class of implants made possible by advances in monolithic electronic design and implant packaging is small enough to be implanted by percutaneous injection through large-gauge hypodermic needles and does not require surgical implantation. Among these, commercially available implants, known as radio frequency identification (RFID) tags, are used for livestock, pet, laboratory animal, and endangered-species identification. The RFID tag is a subminiature glass capsule containing a solenoidal coil and an integrated circuit. Acting as the implanted half of a transcutaneous magnetic link, the RFID tag is powered by and communicates with an extracorporeal magnetic reader. The tag transmits a unique identification code that serves the function of identifying the animal. Millions of RFID tags have been sold since the early 1980s. Based on the success of the RFID tags, research laboratories have developed injectable medical implants, known as micromodules. One type of micromodule, the microstimulator, is designed for use in functional-neuromuscular stimulation. Each microstimulator is uniquely addressable and could comprise one channel of a multichannel functional-neuromuscular stimulation system. Using bidirectional telemetry and commands, from a single extracorporeal transmitter, as many as 256 microstimulators could form the hardware basis for a complex functional-neuromuscular stimulation feedback-control system. Uses include stimulation of paralyzed muscle, therapeutic functional-neuromuscular stimulation, and neuromodulatory functions such as laryngeal stimulation and sleep apnea.
Position location using wireless communications on highways of the future (1996)

With the advances in wireless communications and low-power electronics, accurate position location may now be accomplished by a number of techniques which involve commercial wireless services. Emerging position location systems, when used in conjunction with mobile communications services, will lead to enhanced public safety and revolutionary products and services. The fundamental technical challenges and business motivations behind wireless position location systems are described, and promising techniques for solving the practical position location problem are treated.
Can multilevel signaling improve the spectral efficiency of ASK optical FDM systems? (1993)

The question of whether multilevel signaling can improve the spectral efficiency of optical frequency division multiplexing (FDM) systems is investigated. Multilevel amplitude-shift keying (ASK) and a receiver consisting of an optical channel selection filter (specifically, a single-stage Fabry-Perot), a pin diode for direct detection, and an integrator are assumed. It is also assumed that additive noise is negligible and that the major impairments are adjacent channel interference and intersymbol interference. The analysis shows that, for such a receiver, there is no advantage to going beyond binary signaling. It is also shown that this finding holds up when additive and phase noises and alternative approaches to filtering are considered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Peri‐operative stroke in general surgical patients (1997)

The incidence and aetiology of peri-operative stroke in patients undergoing general surgical procedures are reviewed. Some general recommendations on the peri-operative anaesthetic management of these patients are summarised.
Composite electroceramics (1986)

Abstract Some of the concepts employed in composite electroceramics are reviewed in this paper: connectivity, sum and product properties, coupled phase transformations, polychromatic percolation, mechanical stress and electric field concentration, and symmetry rules. Electronic applications are described for most of the ideas.
Immunology of the human papilloma virus in relation to cancer (1994)

Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore, vaccines targeted to these proteins may provide an opportunity to prevent and treat HPV-associated malignancies. The encouraging results from recent experimental vaccination systems in animal models suggest that continued exploration in these systems might lead to trials on human subjects and might allow us to prevent HPV infection or control its potentially life-threatening consequences.
A dual-metal-trench Schottky pinch-rectifier in 4H-SiC (1998)

Characteristics of high-voltage dual-metal-trench (DMT) SiC Schottky pinch-rectifiers are reported for the first time. At a reverse bias of 300 V, the reverse leakage current of the SiC DMT device is 75 times less than that of a planar device while the forward bias characteristics remain comparable to those of a planar device. In this work, 4H-SiC pinch-rectifiers have been fabricated using a small/large barrier height (Ti/Ni) DMT device structure. The DMT structure is specially designed to permit simple fabrication in SiC. The Ti Schottky contact metal serves as a self-aligned trench etch mask and only four basic fabrication steps are required.
Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants (1999)

Rapid production of protein-based tumor-specific vaccines for the treatment of malignancies is possible with the plant-based transient expression system described here. We created a modified tobamoviral vector that encodes the idiotype-specific single-chain Fv fragment (scFv) of the immunoglobulin from the 38C13 mouse B cell lymphoma. Infected Nicotiana benthamiana plants contain high levels of secreted scFv protein in the extracellular compartment. This material reacts with an anti-idiotype antibody by Western blotting, ELISA, and affinity chromatography, suggesting that the plant-produced 38C13 scFv protein is properly folded in solution. Mice vaccinated with the affinity-purified 38C13 scFv generate >10 micrograms/ml anti-idiotype immunoglobulins. These mice were protected from challenge by a lethal dose of the syngeneic 38C13 tumor, similar to mice immunized with the native 38C13 IgM-keyhole limpet hemocyanin conjugate vaccine. This rapid production system for generating tumor-specific protein vaccines may provide a viable strategy for the treatment of non-Hodgkin's lymphoma.
Maternal Exposure to Exogenous Nitrogen Compounds and Complications of Pregnancy (1997)

Increased lipid peroxidation and reduced antioxidant activity have been reported with pregnancy complications. Given that exogenous oxidants stimulate formation of lipid peroxides, the authors investigated the relationship between exposure to nitrogen-oxidizing species and pregnancy complications and took into account markers of antioxidant and oxidant status. The study sample included pregnant women who were from an area polluted by oxidized nitrogen compounds. Methemoglobin, a biomarker of individual exposure, was determined, as were measures of oxidant/antioxidant status, including glutathione balance and lipid peroxide levels. Only 10 women experienced normal pregnancies. The most common complications were anemia (67%), threatened abortion/premature labor (33%), and signs of preeclampsia (23%). Methemoglobin was elevated significantly in all three conditions, compared with normal pregnancies. Reduced:total glutathione decreased, whereas lipid peroxide levels increased. These results suggest that maternal exposure to environmental oxidants can increase the risk of pregnancy complications through stimulation of the formation of cell-damaging lipid peroxides and from a decrease in maternal antioxidant reserves.
Special Education and Spiritual Formation (2010)

Faith-learning integration is a complex and sometimes challenging issue for university faculty, and something which our students have not likely engaged in. Rather than “integration,” emphasis will be on how Christian thought informs educational practice, and contributes to our spiritual formation, igniting flames of faith-learning and helping prepare caring and competent teachers.
Screening helical CT for mass screening of lung cancer: application of low-dose and single-breath-hold scanning. (1998)

Screening helical CT with low-dose and single-breath-hold scanning shows promise for lung cancer screening.
Microvascular Occlusive Lesions in Primary Thrombocythaemia (1977)

S ummary . Although haemorrhagic manifestations are common in primary thrombocythaemia, microvascular occlusive lesions often leading to peripheral gangrene are frequent and can be the sole clinical manifestation of the disease. Twenty‐seven patients were followed for periods of 6 months to 14 years. The microvascular occlusive group of nine patients presented with distal gangrene of toes, a purple mottled appearance of the skin resembling lesions of livedo reticularis pain aggravated by warmth and erythromelalgia. These ischaemic lesions appearing without demonstrable arterial disease indicate a primary role of the platelets in the occlusive process. None of these patients presented with haemorrhagic symptoms but many later showed abnormal post‐traumatic bleeding. The ischaemic lesions including the gangrenous toes were completely reversed by treatment and did not recur. Ten patients presented with characteristic features of primary haemorrhagic thrombocythaemia. The haemorrhagic manifestations ranged from small, recurrent and multiple ecchymoses to recurring gastro‐intestinal blood loss, massive spontaneous haematoma and excessive post‐operative bleeding. An asymptomatic group of six patients were diagnosed during routine investigation of other disorders. In none of them did a causal relationship seem possible. The miscellaneous group consisted of two patients with the characteristic clinical and haematological features of primary thrombocythaemia who when successfully treated, developed polycythaemia. Busulphan was shown to be effective in controlling the proliferative process in all groups.
Multiple trellis coded modulation (MTCM) (1988)

The authors demonstrate a trellis coded modulation technique referred to as multiple trellis coded modulation (MTCM) wherein more than one channel symbol per trellis branch is transmitted. They have found simple two-state trellis codes for symmetric MPSK multiple phase-shift keying and AM modulations that can achieve 3-dB gain over uncoded modulation at very high signal-to-noise ratios without bandwidth expansion or reduction in information bit rate. The gain of these codes with respect to previously reported two-state trellis codes is between 1 and 2 dB at very high signal-to-noise ratios, depending on the number of bits per Hertz transmitted. These gains are achieved for those of the equivalent conventional trellis codes with the same number of states in the trellis diagram. The authors note that additional computations per branch are needed for the multiple trellis coding scheme. The concept can be extended to a higher number of states and other types of modulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Using planning techniques to provide feedback in interactive learning environments (2002)

A scheme for domain and task representation in an interactive learning environment is described. The approach, based on recent enhancements to a classic AI planning formulation, enables suitable feedback to be incorporated economically into tutors for a range of procedural domains. The method is applied to the problem of simulating the operation of a video cassette recorder and representing tasks within this domain.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains (2016)

Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane. Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is not fully understood. Different experiments have led to different models, including (<i>i</i>) blockage of cell wall synthesis, (<i>ii</i>) membrane pore formation, and (<i>iii</i>) the generation of altered membrane curvature leading to aberrant recruitment of proteins. To determine which model is correct, we carried out a comprehensive mode-of-action study using the model organism <i>Bacillus subtilis</i> and different assays, including proteomics, ionomics, and fluorescence light microscopy. We found that daptomycin causes a gradual decrease in membrane potential but does not form discrete membrane pores. Although we found no evidence for altered membrane curvature, we confirmed that daptomycin inhibits cell wall synthesis. Interestingly, using different fluorescent lipid probes, we showed that binding of daptomycin led to a drastic rearrangement of fluid lipid domains, affecting overall membrane fluidity. Importantly, these changes resulted in the rapid detachment of the membrane-associated lipid II synthase MurG and the phospholipid synthase PlsX. Both proteins preferentially colocalize with fluid membrane microdomains. Delocalization of these proteins presumably is a key reason why daptomycin blocks cell wall synthesis. Finally, clustering of fluid lipids by daptomycin likely causes hydrophobic mismatches between fluid and more rigid membrane areas. This mismatch can facilitate proton leakage and may explain the gradual membrane depolarization observed with daptomycin. Targeting of fluid lipid domains has not been described before for antibiotics and adds another dimension to our understanding of membrane-active antibiotics.
Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes (2008)

CB1 receptor blockade increases mitochondrial biogenesis in white adipocytes by inducing the expression of eNOS. This is linked to the prevention of high-fat diet-induced fat accumulation, without concomitant changes in food intake.
Preserving Coherence in Quantum Computation by Pairing Quantum Bits (1997)

A scheme for protecting quantum states from both independent and cooperative decoherence is proposed. The scheme operates by pairing each qubit (two-state quantum system) with an ancilla qubit and by encoding the states of the qubits into corresponding coherence-preserving states of qubit pairs. In this scheme, amplitude damping (loss of energy) as well as phase damping (dephasing) is prevented by a strategy called ``free-Hamiltonian elimination.'' We further extend the scheme to include quantum gate operations and show that loss and decoherence during such operations can also be prevented.
The effect of triclosan on mediators of gingival inflammation (1995)

Triclosan (2,4,4',-trichloro-2'-hydroxydiphenylether) is a well-known and widely used nonionic antibacterial agent which has recently been introduced in toothpastes and mouthrinses. The efficacy of triclosan-containing toothpaste and mouthrinse to reduce both plaque and gingivitis in long-term clinical trials has been well documented. Until recently, it was generally assumed that triclosan's effect on gingival inflammation was due to its antimicrobial and anti-plaque effect. It has now become apparent that triclosan may have a direct anti-inflammatory effect on the gingival tissues. Several in vitro studies were conducted to evaluate the effect of triclosan on 4 primary enzymes of the pathways of arachidonic acid metabolism, cyclo-oxygenase 1, cyclo-oxygenase 2, 5-lipoxygenase and 15-lipoxygenase. These pathways lead to the production of known mediators of inflammation such as the prostaglandins, leukotrienes and lipoxins. Triclosan inhibited both cyclooxygenase 1 and cyclo-oxygenase 2 with IC-50 values of 43 microM and 227 microM, respectively. Triclosan also inhibited 5-lipoxygenase with an IC-50 of 43 microM. The 15-lipoxygenase was similarly inhibited by triclosan with an IC-50 of 61 microM. Hence, triclosan has the ability to inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism with similar efficacy. In cell culture experiments, it was found that triclosan inhibited IL-1 beta induced prostaglandin E2 production by human gingival fibroblasts in a concentration dependent manner, and at relatively low concentrations. These data, taken together, indicate that triclosan can inhibit formation of several important mediators of gingival inflammation.(ABSTRACT TRUNCATED AT 250 WORDS)
Recombinant Tissue-Type Plasminogen Activator (Alteplase) for Ischemic Stroke 3 to 5 Hours After Symptom Onset (1999)

This study found no significant rt-PA benefit on the 90-day efficacy end points in patients treated between 3 and 5 hours. The risk of symptomatic ICH increased with rt-PA treatment. These results do not support the use of intravenous rt-PA for stroke treatment beyond 3 hours.
Structural basis for chemokine recognition and activation of a viral G protein–coupled receptor (2015)

Chemokines are small proteins that function as immune modulators through activation of chemokine G protein-coupled receptors (GPCRs). Several viruses also encode chemokines and chemokine receptors to subvert the host immune response. How protein ligands activate GPCRs remains unknown. We report the crystal structure at 2.9 angstrom resolution of the human cytomegalovirus GPCR US28 in complex with the chemokine domain of human CX3CL1 (fractalkine). The globular body of CX3CL1 is perched on top of the US28 extracellular vestibule, whereas its amino terminus projects into the central core of US28. The transmembrane helices of US28 adopt an active-state-like conformation. Atomic-level simulations suggest that the agonist-independent activity of US28 may be due to an amino acid network evolved in the viral GPCR to destabilize the receptor's inactive state.
Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey (2000)

We studied the corticocortical connections of architectonically defined areas of parietal and temporoparietal cortex, with emphasis on areas in the intraparietal sulcus (IPS) that are implicated in visual and somatosensory integration. Retrograde tracers were injected into selected areas of the IPS, superior temporal sulcus, and parietal lobule. The distribution of labeled cells was charted in relation to architectonically defined borders throughout the hemisphere and displayed on computer-generated three-dimensional reconstructions and on cortical flat maps. Injections centered in the ventral intraparietal area (VIP) revealed a complex pattern of inputs from numerous visual, somatosensory, motor, and polysensory areas, and from presumed vestibular- and auditory-related areas. Sensorimotor projections were predominantly from the upper body representations of at least six somatotopically organized areas. In contrast, injections centered in the neighboring ventral lateral intraparietal area (LIPv) revealed inputs mainly from extrastriate visual areas, consistent with previous studies. The pattern of inputs to LIPv largely overlapped those to zone MSTdp, a newly described subdivision of the medial superior temporal area. These results, in conjunction with those from injections into other parietal areas (7a, 7b, and anterior intraparietal area), support the fine-grained architectonic partitioning of cortical areas described in the preceding study. They also support and extend previous evidence for multiple distributed networks that are implicated in multimodal integration, especially with regard to area VIP. J. Comp. Neurol. 428:112–137, 2000. © 2000 Wiley-Liss, Inc.
<title>Calibration of TV cameras through RBF networks</title> (1997)

Distortions are introduced by standard TV cameras on the filmed images. These are due to optics and electronics and cause a systematic displacement of the image points with respect to their true position which is given by the geometrical perspective. In order to correct this error, in classical photogrammetrical approaches, the coordinates of the points are transformed through global polynomials whose coefficients are estimated from a set of reference points placed on regular grids. These approaches do not work well when, as in most of the cases, the distortions are highly irregular, and residual errors over the images can be relatively high. In this paper a solution based on RBF networks is proposed. It takes advantage of the quasi-local nature of the network elements to get a uniform small residual distortion error over all the TV image. The structural parameters of the network (namely their number and variance) are set according to criteria inspired to linear filtering theory and the weights are computed following a MAP criterion. Tests on simulated distortions and on real data have been carried. The results reported here show that the RBF networks achieve a better reduction of the distortions in all the tested conditions.
Hepatitis E virus (2006)

Hepatitis E virus (HEV) is the aetiological agent of non-HAV enterically transmitted hepatitis. It is the major cause of sporadic as well as epidemic hepatitis, which is no longer confined to Asia and developing countries but has also become a concern of the developed nations. In the Indian subcontinent, it accounts for 30-60% of sporadic hepatitis. It is generally accepted that hepatitis E is mostly self-limited and never progresses to chronicity. It has a higher mortality in pregnant women where the disease condition is accentuated with the development of fulminant liver disease. Currently, no antiviral drug or vaccine is licensed for HEV, although a vaccine candidate is in clinical trials. HEV genome is 7.2kb in size with three open reading frames (ORFs) and 5' and 3' cis acting elements, which have important roles to play in HEV replication and transcription. ORF1 codes for methyl transferase, protease, helicase and replicase; ORF2 codes for the capsid protein and ORF3 for a protein of undefined function. HEV has recently been classified in the genus Hepevirus of the family Hepeviridae. There are four major recognised genotypes with a single known serotype. The absence of a reliable in vitro propagation system is an obstacle to deciphering HEV biology. The genome of HEV has been cloned, sequenced and the infectious nature of these replicons has been established. However, questions related to replication, transcription, virus-host interactions and pathogenesis remain to be answered. This comprehensive review summarises the progress made so far in HEV research, and addresses some of the unanswered questions.
Flag Commit: Supporting Efficient Transaction Recovery in Flash-Based DBMSs (2011)

Owing to recent advances in semiconductor technologies, flash disks have been a competitive alternative to traditional magnetic disks as external storage media. In this paper, we study how transaction recovery can be efficiently supported in database management systems (dbmss) running on slc flash disks. Inspired by the classical shadow-paging approach, we propose a new commit scheme, called flagcommit, to exploit the unique characteristics of flash disks such as fast random read access, out-place updating, and partial page programming. To minimize the need of writing log records, we embed the transaction status into flash pages through a chain of commit flags. Based on flagcommit, we develop two recovery protocols, namely commit-based flag commit (cfc) and abort-based flag commit (afc), to meet different performance needs. They are flexible to support no-force buffer management and fine-grained concurrency control. Our performance evaluation based on the tpc-c benchmark shows that both cfc and afc outperform the state-of-the-art recovery protocols.