gebhart/patrepeval huggingface dataset:
Ochratoxine A et néphropathie humaine en Tunisie : dix ans d'étude (2003)

L'ochratoxine A (OTA) est une mycotoxine connue essentiellement pour ses effets néphrotoxiques. Des études réalisées dans les régions balkaniques ont fortement soupçonné l'OTA d'être le principal agent causal de la Néphropathie Endémique des Balkans (NEB). Cependant, malgré les nombreuses investigations réalisées, l'implication de l'OTA dans cette néphropathie humaine est encore sujette à controverse. En Tunisie, une néphropathie interstitielle chronique (NIC) à étiologie indéterminée, similaire à la NEB, où l'OTA semble également être impliquée, a été bien caractérisée. Dans ce travail, nous nous proposons d'apporter des preuves supplémentaires impliquant davantage l'OTA dans cette néphropathie. Nous présentons le bilan d'une étude rétrospective de dix ans (1991-2001) engageant 954 néphropathes et 205 individus sains. Dans ce bilan, nous comparons les contaminations sériques en OTA dans trois groupes : un groupe d'individus sains ne présentant aucune pathologie (205 sujets), un groupe de néphropathes présentant une NIC inexpliquée (383 sujets) et un groupe de néphropathes à étiologie connue (571 sujets). La détection et le dosage de l'OTA sont réalisés après extraction à partir des échantillons sériques suivie d'une analyse par chromatographie liquide haute performance (HPLC) avec détection de fluorescence. Nous montrons que l'incidence la plus importante de la contamination sérique en OTA est trouvée dans le groupe présentant une NIC inexpliquée. En effet, dans ce groupe, le pourcentage d'individus OTA-positifs est de 97 % et il n'est que de 73 % et de 86 % respectivement chez les individus sains et chez ceux présentant d'autres néphropathies à étiologie connue. Les concentrations moyennes sont également plus élevées dans le groupe de NIC d'étiologie inconnue (50.77 ± 4.75 ng/ml) que dans les autres groupes de contrôle (2.35 ± 0.90 ng/ml) ou de néphropathes à etiologies connues (9.96 ± 3 ng/ml). Notre étude renforce davantage le rôle de VOTA dans cette néphropathie et la désigne comme agent causal très probable.
[Uricolytic therapy. Value of urate oxidase in the treatment of hyperuricemias]. (1975)

In addition to uricosuric agents and purine synthesis inhibitors, Urate Oxydase may be used in the treatment of hyperuricaemia. This substance breaks down uric acid to allantoin which is soluble and easily excreted. Use of the medication in 14 cases of major gout with tophi and 9 cases of hyperuricaemia secondary to renal insufficiency showed the good tolerance of the substance and it's clinical and biological effectiveness.
Moral Fictionalism (2008)

Book Review| July 01 2008 Moral Fictionalism Mark Eli Kalderon, Moral Fictionalism. Oxford: Oxford University Press, 2005. xii + 193 pp. Tristram McPherson Tristram McPherson Search for other works by this author on: This Site Google The Philosophical Review (2008) 117 (3): 445–448. https://doi.org/10.1215/00318108-2008-004 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Tristram McPherson; Moral Fictionalism. The Philosophical Review 1 July 2008; 117 (3): 445–448. doi: https://doi.org/10.1215/00318108-2008-004 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsThe Philosophical Review Search Advanced Search The text of this article is only available as a PDF. Cornell University2008 Article PDF first page preview Close Modal You do not currently have access to this content.
Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell. (1989)

We have studied the in vivo spleen colony-forming ability and marrow repopulating ability of murine bone marrow cells differing in mitochondrial activity. Following centrifugal elutriation the cells were sorted on the basis of rhodamine-123 fluorescence intensity within a predetermined light scatter window. It is shown that a class of hemopoietic stem cells exists that differs from the majority of day-12 spleen colony-forming units (CFU-S) in that it has low mitochondrial activity and a high capacity to generate in time new day-12 CFU-S and cells that rescue recipients from radiation-inflicted death. These data add direct evidence for the identity of pre-CFU-S and CFU-S by physical separation.
Entwicklung eines Verfahrens zum transvaskulären Aortenklappenersatz (2004)

Bei einem stetig zunehmenden Patientengut mit behandlungsbedurftigen Aortenklappenvitien und relevanten Begleiterkrankungen, welche das Risiko eines operativen Klappenersatzes erhohen, wurde ein Verfahren zum transvaskularen Ersatz der Aortenklappe entwickelt. In umfangreichen In-vitro-Experimenten konnte gezeigt werden, dass eine biologische Herzklappenprothese, die in das proximale Ende eines selbstexpandierenden Nitinolstents eingenaht wurde, nach Zusammenfalten und Implantation mit einem 7 mm dicken Katheter stromungsdynamisch einer nativen Herklappe ahnliche Eigenschaften in einem kunstlichen Kreislaufmodell aufweist. Der Aortenklappenstent wurde uber einen Zugang von der Arteria subclavia unter Rontgendurchleuchtung erfolgreich in Schweine am schlagenden Herzen implantiert, indem beim Freisetzen des Klappenstents aus dem Katheter die alte Aortenklappe gegen die Wand gepresst wurde, wahrend sich gleichzeitig die Bioprothese orthotop entfaltete. Unter Steigerung des Blutdruckes und der Pulsfrequenz durch Katecholamininfusionen konnte sowohl im Katheterruckzug als auch bei den Dopplerflussmessungen mittels transosophagealer Echokardiographie keine Fehlfunktion des Aortenklappenstents festgestellt werden. Dieses neu entwickelte Verfahren des transvaskularen Klappenersatzes, welche minimalinvasiv ohne Narkose und ohne Eroffnung des Brustkorbes moglich ist, kann zukunftig bei Hochrisikopatienten eine alternative Behandlungsmethode fur Aortenklappenerkrankungen darstellen.
The Debate over Schooling:Influences of Dewey and Thorndike (1991)

(1991). The Debate over Schooling: Influences of Dewey and Thorndike. Childhood Education: Vol. 68, No. 2, pp. 71-75.
Experimental Pancreatitis in the Rat (1980)

Necrotic lesions caused by the intraductal injection of sodium taurocholate in rat pancreas were studied by electron microscopy. The early (1 and 15 min after the injection) ductal cells were often necrotic. The acinar cell damage was characterized by mitochondrial swelling, vesiculation of the granular endoplasmic reticulum, and dissolution of cellular membranes. At later time intervals (1, 3, and 6 h) there were necrotic acinar cells with heterogeneous cytoplasmic inclusions representing degenerative cell organelles and their remnants. At 6, 12, and 24 h there were autophagic vacuoles in sublethally damaged acinar cells. The zymogen granules seemed relatively well preserved throughout the experiment. The vascular lesions consisted of endothelial detachment, extravasation of erythrocytes, thrombosis, and poikilocytosis. It was concluded that the initial cell injury was caused by the detergent action of the injected bile salt.
Facile Synthesis of Troilite (2007)

Low-temperature synthetic pathways can result in crystallization of metastable materials. These methods have been widely explored for the preparation of metal oxides. Adaptation of nonhydrolytic sol-gel chemistry to non-oxide systems offers an elegant route to transition-metal sulfides. The method can be exploited for the facile and reproducible synthesis of iron sulfide crystallizing in the troilite structure. This phase is only found in meteorites and planets and has previously been obtained by high-temperature or high-energy ball-milling methods. "Nonhydrolytic" sol-gel processing results in direct crystallization of troilite with no need for further calcination.
Degradation of the Tumor Suppressor PML by Pin1 Contributes to the Cancer Phenotype of Breast Cancer MDA-MB-231 Cells (2007)

Promyelocytic leukemia protein (PML) is an important regulator due to its role in numerous cellular processes including apoptosis, viral infection, senescence, DNA damage repair, and cell cycle regulation. Despite the role of PML in many cellular functions, little is known about the regulation of PML itself. We show that PML stability is regulated through interaction with the peptidyl-prolyl cis-trans isomerase Pin1. This interaction is mediated through four serine-proline motifs in the C terminus of PML. Binding to Pin1 results in degradation of PML in a phosphorylation-dependent manner. Furthermore, our data indicate that sumoylation of PML blocks the interaction, thus preventing degradation of PML by this pathway. Functionally, we show that in the MDA-MB-231 breast cancer cell line modulating levels of Pin1 affects steady-state levels of PML. Furthermore, degradation of PML due to Pin1 acts both to protect these cells from hydrogen peroxide-induced death and to increase the rate of proliferation. Taken together, our work defines a novel mechanism by which sumoylation of PML prevents Pin1-dependent degradation. This interaction likely occurs in numerous cell lines and may be a pathway for oncogenic transformation.
Real-time 6-DOF monocular visual SLAM in a large-scale environment (2014)

Real-time approach for monocular visual simultaneous localization and mapping (SLAM) within a large-scale environment is proposed. From a monocular video sequence, the proposed method continuously computes the current 6-DOF camera pose and 3D landmarks position. The proposed method successfully builds consistent maps from challenging outdoor sequences using a monocular camera as the only sensor, while existing approaches have utilized additional structural information such as camera height from the ground. By using a binary descriptor and metric-topological mapping, the system demonstrates real-time performance on a large-scale outdoor environment without utilizing GPUs or reducing input image size. The effectiveness of the proposed method is demonstrated on various challenging video sequences including the KITTI dataset and indoor video captured on a micro aerial vehicle.
Expression of Heat Shock Protein After Ischemic Preconditioning in Rabbit Hearts (1998)

Previous studies have shown that preconditioning (PC) with a brief ischemic episode induces heat shock protein (HSP) in cardiac tissue. However, it is unclear when and where in the left ventricle HSP is expressed after PC. Hence, the expression of HSP was studied in rabbit hearts at various time intervals after PC using immunohistochemical methods. Rabbits were preconditioned four times with 5 min of occlusion and 5 min of reperfusion of the coronary artery and then were killed at 0, 3, 24, 48, 72 and 168 h after the PC (n=4, for each time interval). Samples were obtained from the subendocardium and subepicardium of the preconditioned and nonpreconditioned wall and these were processed to 4 microm thick cryosections. The sections were immunolabelled with mouse monoclonal IgGs against HSP 72/73. Positive immunoreactivity was observed as early as 3 h after PC, persisting up to 72 h but not detected at 168 h. HSP was expressed not only in the preconditioned myocardium but also in the remote nonpreconditioned myocardium. There was a wide variation in expression among myocytes. Expression was dominant in myocytes compared with vessel walls. It was concluded that PC induced transient and inhomogeneous expression of HSP in rabbit hearts.
Lipopolysaccharide-Induced Gelatinase Granule Mobilization Primes Neutrophils for Activation by Galectin-3 and Formylmethionyl-Leu-Phe (2001)

We have earlier shown that galectin-3, a lactose-binding mammalian lectin that is secreted from activated macrophages, basophils, and mast cells, induces activation of the NADPH oxidase in exudated but not in peripheral blood neutrophils (A. Karlsson, P. Follin, H. Leffler, and C. Dahlgren, Blood 91:3430-3438, 1998). The alteration in responsiveness occurring during extravasation correlated with mobilization of the gelatinase and/or specific granules to the cell surface, indicating a role for mobilizable galectin-3 receptors. In this study we have investigated galectin-3-induced NADPH oxidase activation, measured as superoxide production, in lipopolysaccharide (LPS)-primed neutrophils. Upon galectin-3 challenge, the LPS-primed cells produced superoxide, both extracellularly and intracellularly. A primed extracellular response to formylmethionyl-Leu-Phe (fMLF) was also achieved. The exposure of complement receptors 1 and 3 as well as the formyl peptide receptor on the cell surface was markedly increased after LPS treatment, indicating that granule fusion with the plasma membrane had occurred. Further assessment of specific markers for neutrophil granules showed that the LPS treatment had mobilized the gelatinase granules but only a minor fraction of the specific granules. We thus suggest that the mechanism behind LPS priming lies at the level of granule (receptor) mobilization for galectin-3 as well as for fMLF.
Antiviral Potency of Drug—Gene Therapy Combinations against Human Immunodeficiency Virus Type 1 (1997)

Gene therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infection using intracellular immunization strategies is currently being tested in clinical trials. With the continuing development of potent antiretroviral drugs (e.g., reverse transcriptase [RT] and protease [PR] inhibitors), it is likely that HIV-1 gene therapy will be applied to humans concurrently receiving such antiretroviral medication. In this study, we assessed the in vitro antiviral efficacy of two gene therapy strategies (trans-dominant RevM10, Gag antisense RNA) in combination with clinically relevant RT (AZT, ddC) or PR (indinavir) inhibitors. Retrovirally transduced, human T cell lines expressing antiviral gene constructs were inoculated with high doses of HIV-1HXB3 in the presence or absence of inhibitors. The combination of RevM10 or Gag antisense RNA with antiviral drugs inhibited HIV-1 replication 10-fold more effectively than the single antiviral drug regimen alone. More importantly, we also addressed whether gene therapy strategies are effective against drug-resistant HIV-1 isolates. Both the RevM10 and Gag antisense RNA strategies showed antiviral efficacy against several RT inhibitor-resistant HIV-1 isolates equivalent to their inhibition of HIV-1HXB3 replication. In summary, our data demonstrate the greater than additive antiviral efficacy of gene therapy strategies and RT or PR inhibitors, and that gene therapy approaches are effective against drug-resistant HIV-1 viral isolates.
Projective surfaces with many skew lines (2004)

We give an example of a smooth surface <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="normal upper S Subscript d Baseline subset-of double-struck upper P 3 left-parenthesis double-struck upper C right-parenthesis"> <mml:semantics> <mml:mrow> <mml:msub> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="normal">S</mml:mi> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi>d</mml:mi> </mml:mrow> </mml:msub> <mml:mo> ⊂ </mml:mo> <mml:msub> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="double-struck">P</mml:mi> </mml:mrow> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mn>3</mml:mn> </mml:mrow> </mml:msub> <mml:mo stretchy="false">(</mml:mo> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mi mathvariant="double-struck">C</mml:mi> </mml:mrow> <mml:mo stretchy="false">)</mml:mo> </mml:mrow> <mml:annotation encoding="application/x-tex">\mathrm {S}_{d}\subset \mathbb {P}_{3}(\mathbb {C})</mml:annotation> </mml:semantics> </mml:math> </inline-formula> of degree <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="d"> <mml:semantics> <mml:mi>d</mml:mi> <mml:annotation encoding="application/x-tex">d</mml:annotation> </mml:semantics> </mml:math> </inline-formula> that contains <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="d dot left-parenthesis d minus 2 right-parenthesis plus 2"> <mml:semantics> <mml:mrow> <mml:mi>d</mml:mi> <mml:mo> ⋅ </mml:mo> <mml:mo stretchy="false">(</mml:mo> <mml:mi>d</mml:mi> <mml:mo> − </mml:mo> <mml:mn>2</mml:mn> <mml:mo stretchy="false">)</mml:mo> <mml:mo>+</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> <mml:annotation encoding="application/x-tex">d \cdot (d-2) + 2</mml:annotation> </mml:semantics> </mml:math> </inline-formula> pairwise disjoint lines. In particular, our example shows that the degree in Miyaoka’s bound is sharp.
Nectin‐dependent localization of synaptic scaffolding molecule (S‐SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus (2003)

These results indicate that S-SCAM localizes at the PAs in the CA3 area of the hippocampus in a nectin-dependent manner and suggest that S-SCAM serves as a scaffolding molecule at the PAs after maturation of the synapses and at the SJs during the maturation.
Expression of the REB transcriptional activator in rice grains improves the yield of recombinant proteins whose genes are controlled by a Reb -responsive promoter (2001)

The gene encoding the rice transcription factor, REB (rice endosperm bZIP) was cloned from a bacterial artificial chromosome library of rice. The cloned 6,227-bp-long Reb gene is composed of six exons and five introns and is flanked by a 1.2-kb 5' promoter and a 1.2-kb 3' terminator region. The function of the Reb gene was explored by a transient assay by using a rice immature endosperm system. The effector constructs containing the native gene or fusion genes linking Reb to the rice actin (Act) or globulin (Glb) gene promoters and the reporter gene construct Glb-beta-glucuronidase (GUS) were used in this study. When these effector constructs were cotransferred with the reporter uidA gene encoding GUS under the control of the Glb promoter into immature rice endosperm cells, the Glb promoter was activated. The transient GUS expression was 2.0 to 2.5-fold higher with the effector construct than without. When the upstream activation sequence containing the GCCACGT(A/C)AG motifs of the Glb promoter was deleted, the activation by REB was abolished. On the other hand, a gain-of-function experiment showed that inserting the upstream activation sequence into the glutelin-1 (Gt1) promoter made it responsive to activation by REB. When cotransformed with Reb gene, mature transgenic rice grains containing the human lysozyme gene driven by the Glb promoter produced 3.7-fold more lysozyme. Accumulation of recombinant lysozyme in mature seed ranged from 30.57 to 279.61 microg.mg(-1) total soluble protein in individual transformants from 30 independent transformation events. Thus, our results show that REB is not only a transcriptional activator, it can also be used to increase the expression of recombinant protein in transgenic rice grains.
Near-Earth Laser Communications (2010)

This chapter is an introduction to the near-Earth laser communication technology. By near-Earth, we mean high-altitude platforms and Earth-orbiting satellites. Justification for high bandwidth delivery capability as well as key advantages and challenges of laser communications are discussed in detail. Critical elements of each subassembly are introduced and elaborated separately for the flight and the ground subsystems. These include the atmospheric effects, laser transmitter, receiver, optomechanical assembly, laser beam acquisition tracking and pointing, modulation and coding. Past successful optical communications links and upcoming field demonstrations and major operational use cases are also summarized here. Each of the following chapters expands on these topics in much greater detail.
A disease resistance gene in Arabidopsis with specificity for two different pathogen avirulence genes. (1994)

The RPS3 and RPM1 disease resistance loci of Arabidopsis confer resistance to Pseudomonas syringae strains that carry the avirulence genes avrB and avrRpm1, respectively. We have previously shown that RPS3 and RPM1 are closely linked genetically. Here, we show that RPS3 and RPM1 are in fact the same gene. We screened a mutagenized Arabidopsis population with a P. syringae strain carrying avrB and found 12 susceptible mutants. All 12 mutants were also susceptible to an isogenic strain carrying avrRpm1, indicating a loss of both RPS3 and RPM1 functions. No mutants were recovered that lost only RPS3 function. Genetic analysis of four independent mutants revealed that the lesions were in RPS3. Thus, a single gene in Arabidopsis confers resistance that is specific to two distinct pathogen avirulence genes--a gene-for-genes interaction. This observation suggests that the RPS3/RPM1 gene product can bind multiple pathogen ligands, or alternatively, that it does not function as a receptor.
Effect of Fusobacterium necrophorum leukotoxoid vaccine on susceptibility to experimentally induced liver abscesses in cattle. (1997)

The efficacy and the optimum dose of Fusobacterium necrophorum crude leukotoxoid vaccine required to immunize and protect steers against experimentally induced liver abscesses were evaluated. The vaccine consisted of cell-free culture supernatant of a high leukotoxin-producing strain of F. necrophorum, inactivated with formalin and homogenized with an adjuvant. Twenty-five steers were assigned randomly to the following five treatment groups: control; three doses (1.0, 2.0, and 5.0 mL) of the culture supernatant; and 2.25 mL of the concentrated supernatant (equivalent to 5 mL of the original supernatant). Vaccine was injected subcutaneously on d 0 and 21. Blood samples were collected weekly to monitor antileukotoxin antibody titers. Three weeks after the second vaccination (d 42), all steers were injected intraportally with F. necrophorum culture to induce liver abscesses. Three weeks later (d 63), steers were euthanatized and necropsied; livers were examined and protection assessed. Antileukotoxin antibody titers in the control steers generally did not differ from the baseline (wk 0) titers. The titers in the vaccinated groups increased, more so after the second injection, and the increase was generally dose-dependent. Necropsy examination revealed that all steers in the control group had abscesses in the liver. In the vaccinated groups, two of five steers in the 1.0-mL group and one each in the 2.0-, 5.0-, and 2.25-mL (concentrated) groups had liver abscesses. Antileukotoxin antibody titers were higher (P < .05) in steers that did not develop abscesses than in steers that developed abscesses. The difference suggested a protective effect of antileukotoxin antibodies against experimentally induced liver abscesses.