gebhart/patrepeval huggingface dataset:
Synthesis of benzofurans from oxygenated phenoxyamines (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of benzofurans from oxygenated phenoxyaminesAngelo J. Castellino and Henry RapoportCite this: J. Org. Chem. 1984, 49, 23, 4399–4404Publication Date (Print):November 1, 1984Publication History Published online1 May 2002Published inissue 1 November 1984https://pubs.acs.org/doi/10.1021/jo00197a014https://doi.org/10.1021/jo00197a014research-articleACS PublicationsRequest reuse permissionsArticle Views567Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Large-scale polymeric carbon nanotube membranes with sub–1.27-nm pores (2018)

We report the first characterization study of commercial prototype carbon nanotube (CNT) membranes consisting of sub-1.27-nm-diameter CNTs traversing a large-area nonporous polysulfone film. The membranes show rejection of NaCl and MgSO<sub>4</sub> at higher ionic strengths than have previously been reported in CNT membranes, and specific size selectivity for analytes with diameters below 1.24 nm. The CNTs used in the membranes were arc discharge nanotubes with inner diameters of 0.67 to 1.27 nm. Water flow through the membranes was 1000 times higher than predicted by Hagen-Poiseuille flow, in agreement with previous CNT membrane studies. Ideal gas selectivity was found to deviate significantly from that predicted by both viscous and Knudsen flow, suggesting that surface diffusion effects may begin to dominate gas selectivity at this size scale.
PREPARATION OFN-TERT-BUTOXYCARBONYLTHIOUREA OPENS THE WAY TO PROTECTED 2-AMINOTHIAZOLES (2002)

ABSTRACT The preparation of N-tert-butoxycarbonylthiourea from thiourea and di-tert-butyldicarbonate in tetrahydrofuran is described. It has been successfully used for the preparation of 2-aminothiazole intermediates. Keywords: 2-AminothiazoleN-tert-Butoxycarbonylthiourea Acknowledgments
A closed-form solution to the autocorrelation matching method for wireless MIMO communications (2004)

Wireless MIMO (multiple input multiple output) communication techniques are proposed to boost spectrum efficiency using antenna arrays so that broadband data such as multimedia signals can be transmitted over a limited bandwidth. The AM (autocorrelation matching) method is a SOS (second-order statistics) based blind MIMO-FIR equalization technique that may enable wireless MIMO communications without identifying MIMO-FIR channels. This paper presents a closed-form solution to computing the optimal zero-forcing equalizer for the AM method using the knowledge of second-order statistics of the transmitted signals and received signals. Numerical simulations are given to show the effectiveness of the AM method and the performance of the closed-form solution.
Effect of opioid antagonists on sex hormone secretion. (2012)

Opioid antagonists seem to increase the secretion of GnRH in the hypothalamus which then causes a pulsatile release of LH in the pituitary and secretion of testosterone. According to the experiments, the frequency of pulses and concentration of LH and testosterone in plasma seem to increase. These effects are seen in both men and women (at early follicular phase). More research is needed to investigate the consequences of these effects in general.
Studying spamming botnets using Botlab (2009)

In this paper we present Botlab, a platform that continually monitors and analyzes the behavior of spamoriented botnets. Botlab gathers multiple real-time streams of information about botnets taken from distinct perspectives. By combining and analyzing these streams, Botlab can produce accurate, timely, and comprehensive data about spam botnet behavior. Our prototype system integrates information about spam arriving at the University of Washington, outgoing spam generated by captive botnet nodes, and information gleaned from DNS about URLs found within these spam messages. We describe the design and implementation of Botlab, including the challenges we had to overcome, such as preventing captive nodes from causing harm or thwarting virtual machine detection. Next, we present the results of a detailed measurement study of the behavior of the most active spam botnets. We find that six botnets are responsible for 79 % of spam messages arriving at the UW campus. Finally, we present defensive tools that take advantage of the Botlab platform to improve spam filtering and protect users from harmful web sites advertised within botnet-generated spam.
In vitro generation of antigen-specific helper T cells that collaborate with cytotoxic T-cell precursors. (1978)

Antigen-specific helper T cells are required in the generation of cytotoxic T cells from thymocyte precursors. We have demonstrated that these alloantigen-specific helper cells can be generated in vitro and that both the quantity and quality of the helpers appear to be superior to the help obtained from unprimed spleen cells. Optimal helper cell activity is produced at day two of culture when CBA splenic helper precursors are stimulated by irradiated allogeneic spleen cells. Helper cell precursors are antigen-specific cells which cannot be instructed to express forbidden receptor specificities and bear theta antigen on their surface. The helper effectors are radioresistant, theta-bearing, and antigen-specific cells.
Molecular Cloning, Expression, and Functional Significance of a Cytochrome P450 Highly Expressed in Rat Heart Myocytes (1997)

A cDNA encoding a P450 monooxygenase was amplified from reverse transcribed rat heart and liver total RNA by polymerase chain reaction using primers based on the 5'- and 3'-end sequences of two rat pseudogenes, CYP2J3P1 and CYP2J3P2. Sequence analysis revealed that this 1,778-base pair cDNA contained an open reading frame and encoded a new 502 amino acid protein designated CYP2J3. Based on the deduced amino acid sequence, CYP2J3 was approximately 70% homologous to both human CYP2J2 and rabbit CYP2J1. Recombinant CYP2J3 protein was co-expressed with NADPH-cytochrome P450 oxidoreductase in Sf9 insect cells using a baculovirus expression system. Microsomal fractions of CYP2J3/NADPH-cytochrome P450 oxidoreductase-transfected cells metabolized arachidonic acid to 14,15-, 11,12-, and 8, 9-epoxyeicosatrienoic acids and 19-hydroxyeicosatetraenoic acid as the principal reaction products (catalytic turnover, 0.2 nmol of product/nmol of cytochrome P450/min at 37 degrees C). Immunoblotting of microsomal fractions prepared from rat tissues using a polyclonal antibody raised against recombinant CYP2J2 that cross-reacted with CYP2J3 but not with other known rat P450s demonstrated abundant expression of CYP2J3 protein in heart and liver. Immunohistochemical staining of formalin-fixed paraffin-embedded rat heart tissue sections using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection localized expression of CYP2J3 primarily to atrial and ventricular myocytes. In an isolated-perfused rat heart model, 20 min of global ischemia followed by 40 min of reflow resulted in recovery of only 44 +/- 6% of base-line contractile function. The addition of 5 microM 11, 12-epoxyeicosatrienoic acid to the perfusate prior to global ischemia resulted in a significant 1.6-fold improvement in recovery of cardiac contractility (69 +/- 5% of base line, p = 0.01 versus vehicle alone). Importantly, neither 14,15-epoxyeicosatrienoic acid nor 19-hydroxyeicosatetraenoic acid significantly improved functional recovery following global ischemia, demonstrating the specificity of the biological effect for the 11, 12-epoxyeicosatrienoic acid regioisomer. Based on these data, we conclude that (a) CYP2J3 is one of the predominant enzymes responsible for the oxidation of endogenous arachidonic acid pools in rat heart myocytes and (b) 11,12-epoxyeicosatrienoic acid may play an important functional role in the response of the heart to ischemia.
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi (2002)

Eukaryotic heterochromatin is characterized by a high density of repeats and transposons, as well as by modified histones, and influences both gene expression and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, we deleted the argonaute, dicer, and RNA-dependent RNA polymerase gene homologs, which encode part of the machinery responsible for RNA interference (RNAi). Deletion results in the aberrant accumulation of complementary transcripts from centromeric heterochromatic repeats. This is accompanied by transcriptional de-repression of transgenes integrated at the centromere, loss of histone H3 lysine-9 methylation, and impairment of centromere function. We propose that double-stranded RNA arising from centromeric repeats targets formation and maintenance of heterochromatin through RNAi.
Diode-pumped femtosecond Yb:YAl/sub 3/(BO/sub 3/)/sub 4/ laser passively mode-locked by an ion-implanted SESAM (2003)

Summary form only given. We report, to our knowledge, the first semiconductor saturable absorber mirror (SESAM) mode-locked Yb:YAl/sub 3/(BO/sub 3/)/sub 4/ (Yb:YAB) laser. Apart from a fluorescence bandwidth of 20 nm, Yb:YAB has a second-order nonlinear coefficient of d/sub eff/ > 1.4 pm/V/sup 4/. With its quasi three-level energy scheme, an upper state lifetime of /spl tau//sub u/ = 0.68 ms and gain cross-section of /spl sigma//sub c/ = 0.8 /spl times/ 10/sup -20/ cm/sup 2/, Yb:YAB requires high brightness pumping and picosecond SESAM response for stable cw mode-locking. We have developed an approach involving ion-implantation and annealing of SESAMs. This versatile process enables response time tailoring on the single device level. The SESAM used in the Yb:YAB laser is shown. A half-wave layer of GaAs, grown upon a semiconductor Bragg-mirror (/spl lambda//sub B/ = 1040 nm), contained three 9.5 nm In/sub 0.26/Ga/sub 0.74/As quantum-wells QW) at the anti-node of the standing-wave intensity distribution.
Influence of proteins Bsp and FemH on cell shape and peptidoglycan composition in group B streptococcus c cThe GenBank accession number for the sequence reported in this paper is AJ305309. (2002)

Group B streptococcus (GBS) is surrounded by a capsule. However, little is known about peptidoglycan metabolism in these bacteria. In the present study, a 65 kDa protein was isolated from the culture supernatant of GBS and N-terminally sequenced, permitting isolation of the corresponding gene, termed bsp. The bsp gene was located close to another gene, designated femH, and reverse transcription-PCR revealed a bicistronic transcriptional organization for both genes. The Bsp protein was detected in the culture supernatant from 31 tested clinical isolates of GBS, suggesting a wide distribution of Bsp in these bacteria. Overexpression of bsp resulted in lens-shaped GBS cells, indicating a role for bsp in controlling cell morphology. Insertional disruption of femH resulted in a reduction of the L-alanine content of the peptidoglycan, suggesting that femH is involved in the incorporation of L-alanine residues in the interpeptide chain of the peptidoglycan of GBS.
Demand based hierarchical QoS using storage resource pools (2012)

The high degree of storage consolidation in modern virtualized datacenters requires flexible and efficient ways to allocate IO resources among virtual machines (VMs). Existing IO resource management techniques have two main deficiencies: (1) they are restricted in their ability to allocate resources across multiple hosts sharing a storage device, and (2) they do not permit the administrator to set allocations for a group of VMs that are providing a single service or belong to the same application. In this paper we present the design and implementation of a novel software system called Storage Resource Pools (SRP). SRP supports the logical grouping of related VMs into hierarchical pools. SRP allows reservations, limits and proportional shares, at both the VM and pool levels. Spare resources are allocated to VMs in the same pool in preference to other VMs. The VMs may be distributed across multiple physical hosts without consideration of their logical groupings. We have implemented a prototype of storage resource pools in the VMware ESX hypervisor. Our results demonstrate that SRP provides hierarchical performance isolation and sharing among groups of VMs running across multiple hosts, while maintaining high utilization of the storage device. 1
Positionally independent and exchangeable late budding functions of the Rous sarcoma virus and human immunodeficiency virus Gag proteins (1995)

The Gag proteins of Rous sarcoma virus and human immunodeficiency virus (HIV) each contain a function involved in a late step in budding, defects in which result in the accumulation of these molecules at the plasma membrane. In the Rous sarcoma virus Gag protein (Pr76gag), this assembly domain is associated with a PPPY motif, which is located at an internal position between the MA and CA sequences. This motif is not contained anywhere within the HIV Gag protein (Pr55gag), and the MA sequence is linked directly to CA. Instead, a late assembly function of HIV has been associated with the p6 sequence situated at the C terminus of Gag. Here we demonstrate the remarkable finding that the late assembly domains from these two unrelated Gag proteins are exchangeable between retroviruses and can function in a positionally independent manner.
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort (2009)

A model incorporating six circulating biomarkers provides an objective and quantitative estimate of the 5-year risk of developing type 2 diabetes, performs better than single risk indicators and a noninvasive clinical model, and provides better stratification than fasting plasma glucose alone.
CD4+ suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental autoimmune encephalomyelitis. (1989)

Spleen cells from rats that have recovered from experimental autoimmune encephalomyelitis (EAE) suppress the production of IFN-gamma by effector T cells of EAE in an Ag-specific manner. These postrecovery suppressor cells also inhibit EAE in vivo. Fractionation of the postrecovery suppressor spleen cells on nylon wool and OX-8 coated plates yields a nylon wool-adherent CD4+ suppressor cell population that, when cocultured with effector T cells, suppresses IFN-gamma production by these effector cells. In contrast, the nylon wool-adherent, CD4+ postrecovery suppressor cell population fails to inhibit the production of IL-2 by the effector T cells. In further experiments, the effector T cell population was depleted of CD8+ cells and cocultured with the nylon wool-adherent, CD4+ postrecovery suppressor cells, and the supernatants were assayed for IFN-gamma and IL-2. IFN-gamma production was inhibited in these cultures but IL-2 production was not inhibited. Irradiated effector T cells were cocultured with CD4+ postrecovery suppressor cells, without myelin basic protein, in an effort to determine whether the mechanism of differential lymphokine suppression involved an anti-idiotypic response against effector T cells. No IL-2 was produced, indicating that there was no CD4+ suppressor cell mediated anti-idiotypic response against effector T cells. These studies suggest that the suppressor cell is a nylon wool adherent, CD4+ T cell that functions to down-regulate EAE effector T cells by differential inhibition of lymphokine production.
Topology, Subcellular Localization, and Sequence Diversity of the Mlo Family in Plants (1999)

Barley Mlo defines the founder of a novel class of plant integral membrane proteins. Lack of the wild type protein leads to broad spectrum disease resistance against the pathogenic powdery mildew fungus and deregulated leaf cell death. Scanning N-glycosylation mutagenesis and Mlo-Lep fusion proteins demonstrated that Mlo is membrane-anchored by 7 transmembrane (TM) helices such that the N terminus is located extracellularly and the C terminus intracellularly. Fractionation of leaf cells and immunoblotting localized the protein to the plant plasma membrane. A genome-wide search for Mlo sequence-related genes in Arabidopsis thaliana revealed approximately 35 family members, the only abundant gene family encoding 7 TM proteins in higher plants. The sequence variability of Mlo family members within a single species, their topology and subcellular localization are reminiscent of the most abundant class of metazoan 7 TM receptors, the G-protein-coupled receptors.
Experimental Gas-Phase Basicity Scale of Superbasic Phosphazenes (2007)

Seventeen superbasic phosphazenes and two Verkade's bases were used to supplement and extend the experimental gas-phase basicity scale in the superbasic region. For 19 strong bases the gas-phase basicity values (GB) were determined for the first time. Among them are such well-known bases as BEMP (1071.2 kJ/mol), Verkade's Me-substituted base (1083.8 kJ/mol), Et-N=P(NMe2)2-N=P(NMe2)3 (Et-P2 phosphazene, 1106.9 kJ/mol), and t-Bu-N=P(NMe2)3 (t-Bu-P1 phosphazene, 1058.0 kJ/mol). For the first time experimental GB values were determined for P2 phosphazenes. Together with our previous results self-consistent experimental gas-phase basicity scale between 1020 and 1107 kJ/mol is now established. This way an important region of the gas-phase basicity scale, which was earlier dominated by metal hydroxide bases, is now covered also with organic bases making it more accessible for further studies. The GB values for several superbases were calculated using density functional theory at the B3LYP/6-311+G** level. For the phosphazene family the standard deviation of the correlation between the experimental and theoretical values was 6.5 kJ/mol.
Listeria monocytogenesVirulence Factors That Stimulate Endothelial Cells (1998)

Listeria monocytogenes infection of endothelial cells upregulates surface expression of adhesion molecules and stimulates neutrophil adhesion to infected cell monolayers. The experiments presented here tested the roles of specific bacterial virulence factors as triggers for this inflammatory phenotype and function. Human umbilical vein endothelial cell (HUVEC) monolayers were infected with wild-type L. monocytogenes or L. monocytogenes mutants; then surface expression of E-selectin and neutrophil adhesion were measured. The results showed that delta hly and prfA mutants were the most crippled, requiring 100-fold more mutant bacteria than wild-type bacteria for analogous stimulation. By comparison, L. monocytogenes mutants with deletions of actA, inlA, inlB, inlAB, plcA, and plcB resembled their parent strains, and a delta plcA delta plcB mutant displayed decreased intracellular growth rate but only a minor decrease in stimulation of E-selectin or neutrophil adhesion. Other experiments showed that cytochalasin D-treated HUVEC monolayers bound bacteria, but internalization and increased surface E-selectin and intercellular adhesion molecule-1 expression were profoundly inhibited. However, cytochalasin D had no effect on the HUVEC response to stimulation with lipopolysaccharide or tumor necrosis factor alpha. These data suggest that listeriolysin O production by infecting L. monocytogenes contributes to increased expression of surface E-selectin and intercellular adhesion molecule-1, but neither it nor intracellular replication are directly responsible for this event. Nonetheless it is possible that listeriolysin O potentiates the effect(s) of an other molecule(s) that directly triggers this response. Additionally, cellular invasion by L. monocytogenes appears to be critical for initiating the HUVEC response, potentially by providing a signal which results in upregulation of the necessary bacterial genes.
New high‐temperature polymers. VIII. Ordered benzoxazole‐ and benzothiazole‐imide copolymers (1969)

Abstract Ordered heterocycle copolymers of high thermal stability were prepared from aromatic dianhydrides reacted with aromatic diamines containing preformed benzoxazole or benzothiazole units. These ordered benzoxazole‐imide and benzothiazole‐imide copolymers were prepared in the form of their soluble precursor polyamic‐acids, which, after fabrication to desired shapes, were converted to the thermally stable polymer. In general, these polymers are more resistant to air oxidation at elevated temperatures than are simple aromatic polyimides, and their thermoöxidative stability is equal to or greater than that reported for benzoxazole or benzothiazole homopolymers. Unlike the o ‐hydroxyamide precursors to simple polybenzoxazoles, the amic acid precursors to benzoxazole‐imide ordered copolymers do not require temperatures above 300°C to complete ring closure nor inert atmospheres to prevent polymer degradation during ring formation. Excellent self‐supporting films and film coatings for metals were prepared. Selected compositions were readily spun to excellent fiber.