gebhart/patrepeval huggingface dataset:
Adaptive control of unknown plants using dynamical neural networks (1994)

In this paper, we are dealing with the problem of controlling an unknown nonlinear dynamical system. The algorithm is divided into two phases. First a dynamical neural network identifier is employed to perform "black box" identification and then a dynamic state feedback is developed to appropriately control the unknown system. We apply the algorithm to control the speed of a nonlinearized DC motor, giving in this way an application insight. In the algorithm, not all the plant states are assumed to be available for measurement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Rule Based Expert Systems: The Mycin Experiments of the Stanford Heuristic Programming Project (The Addison-Wesley series in artificial intelligence) (1984)

We analyze factors determining women's decisions to participate in the labor market and provide elderly care and nonfinancial support to their (grand)children. We use data from the Mexican Health and Aging Study, a survey of people aged 50 and over, applying a three-equation, reduced-form SUR model. Results suggest that care needs are the driving force behind caregiving activities. Traditional roles also appear to be relevant in the labor force participation decision: women with a closer labor market connection when they were young are more likely to work. Simulations of demographic changes illustrate potential effects for future caregiving and participation rates.
Platinum Monolayer Electrocatalysts for O<sub>2</sub> Reduction: Characterization and Synthesis Scale-up (2013)

Development of active, durable, platinum monolayer oxygen reduction reaction catalysts for use in polymer electrolyte membrane fuel cells.
Development of a Nonlinear Material Model for an Internally Confined Hollow Reinforced Concrete Member (2007)

A nonlinear concrete model was developed for a new-type column, internally confined hollow RC column (ICH RC column), with modification of Mander et al.'s uniaxial stress-strain model. An ICH RC column is a hollow RC column which has a straight or corrugated tube inside of itself to enhance its ductility or stiffness by internal confinement. To determine stress-strain model of the concrete in an ICH RC column, possible failure modes of an ICH RC column were suggested and confining pressure was derived from equilibriums for each failure mode. From derived equations, a computer program was coded and the developed analysis model was verified by being compared with results from previous experimental researches. Parametric studies were performed for some examples and the analytical results showed that internally confined concrete has enhanced strength and ductility with comparison of unconfined or biaxially confined concrete.
[Future perspectives of bone marrow and stem cell activation for autologous transplantation]. (1991)

Autologous bone marrow transplantation has gained an increasing role in modern oncology. The use of circulating progenitors from the peripheral blood as autografts might have some important advantages, since leukaphereses are better tolerable than a BM harvest, could be done immediately following chemotherapy, are possible in patients with previous irradiation to the pelvis and might be less contaminated with malignant progenitor cells. We have shown that monitoring transplants with the relatively simple in vitro assay for myeloid progenitor cells is predictive for hematopoietic recovery in animal models as well as in the clinical setting. Moreover, stem cells harvested during repeated leukapheresis were able to repopulate permanently the irradiated BM. Using recombinant human granulocyte/macrophage colony stimulating factor, large quantities of progenitor cells can be mobilized into the peripheral blood and collected for autotransplantation, in particular if used directly following chemotherapy. Cell separation studies showed that a bone marrow/blood barrier retains some subpopulations of progenitor cells which might lead to the preferential circulation of normal stem cells following chemotherapy. Methods are described to distinguish normal and leukemic progenitor cells which will help in the future to assay autografts both for their repopulating ability and their contamination with tumor cells.
Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants (2008)

Aims: To evaluate the association between the presence of bacterial pathogens in the amniotic cavity at the time of preterm delivery and neuromotor outcome at two years adjusted age in preterm infants born at ≤33 weeks' gestation. Methods: The cohort included 114 preterm infants, born at 23–33 weeks' gestation to mothers with amniotic cavity cultures taken during cesarean delivery who were subsequently evaluated at 24.0±1.1 months corrected age with the Bayley Scales of Infant Development II and a standardized neurologic examination. Results: A group of 67 infants with negative amniotic cavity cultures was compared to 47 infants with positive amniotic cavity cultures ( Ureaplasma urealyticum (Uu) in 32 cases and other bacteria in 15 cases). Patients with positive amniotic cavity cultures had a significantly higher risk for an adverse psychomotor development index (PDI) score (OR 3.1, CI 1.3–7.1), an abnormal neurologic outcome (OR 4.8, CI 1.7–13.8), and a higher probability for diagnosis of cerebral palsy (OR 4.8, CI 1.4–16.4) at two years compared to patients with negative culture results. Isolation of Uu at birth was associated with a particular adverse outcome of preterm infants. Conclusions: Isolation of pathogens from the amniotic cavity at birth is significantly associated with abnormal PDI and adverse neuromotor outcome in preterm infants, irrespective of gestational age and birthweight.
Identification of putative insect brush border membrane-binding molecules specific to Bacillus thuringiensis delta-endotoxin by protein blot analysis (1991)

Binding sites for insecticidal toxins of Bacillus thuringiensis are located in the brush border membranes of insect midguts. Two approaches were used to investigate the interactions of B. thuringiensis subsp. kurstaki HD-73 CryIA(c) toxin with brush border membrane vesicles from sensitive and naturally resistant insects: 125I-toxin-vesicle binding assays and protein blots probed with 125I-CryIA(c) toxin. In bioassays, Manduca sexta and Heliothis virescens larvae were highly sensitive, Helicoverpa zea larvae were moderately sensitive, and Spodoptera frugiperda larvae were resistant to CryIA(c) toxin. Studies of binding of 125I-CryIA(c) toxin to brush border membrane vesicles from the larval midguts revealed that all insects tested had high-affinity, saturable binding sites. Significantly, S. frugiperda larvae bind but are not killed by CryIA(c) toxin. Labeled CryIA(c) toxin incubated with protein blots identifies a major binding molecule of 120 kDa for M. sexta and 148 kDa for S. frugiperda. H. virescens and H. zea are more complex, containing 155-, 120-, 103-, 90-, and 63-kDa proteins as putative toxin-binding molecules. H. virescens also contains a minor toxin-binding protein of 81 kDa. These experiments provide information that can be applied toward a more detailed characterization of B. thuringiensis toxin-binding proteins.
The Use of Complementary and Alternative Medicine Among Chinese Women with Breast Cancer (2008)

Given the high prevalence of CAM use in patients with breast cancer and the variety of types of CAM, more research is needed to determine the impact of CAM's effectiveness and safety and interaction with conventional cancer treatment on breast cancer survival.
191 (2012)

Introduction: Cardiac arrest (CA) is an important cause of morbidity and mortality in the adult and pediatric populations. Women and adult female animals demonstrate better outcomes after CA compared to male counterparts, due in large part to their higher levels of circulation estrogen (E2). Consistent with this, E2 treatment is neuroprotective in adult male and female animals following CA via estrogen receptor? (ER?) binding. We investigated the neuroprotective effects of treatment with E2 and ER? agonist DPN in our novel mouse model of pediatric CA. Hypothesis: E2 treatment after CA/cardiopulmonary resuscitation will reduce CA1 hippocampal neuronal death via ER? signaling in male and female juvenile mice. Methods: Male and female juvenile (prepubertal; postnatal day 20-25) mice (C57Bl/6, n=18 and 20, respectively) underwent CA induced by intravenous potassium chloride injection. Following 6 min of ischemia, mice were resuscitated with mechanical ventilation, epinephrine, and chest compressions. 30 min after return of circulation, mice were treated with intravenous E2 (100 µg/kg), ER? agonist diarylpropiolnitrile (DPN, 240 µg/kg), or vehicle. Histopathology with hematoxylin and eosin staining for analysis of CA1 hippocampal neuronal death was performed 3 d after CA/CPR. Neuronal death was calculated as % dead/total neurons, data expressed as mean±SEM. Results: Male and female juvenile mice treated with vehicle exhibited a similar degree of hippocampal CA1 neuronal death after CA/CPR (74 ± 3 and 68 ± 6%, respectively). Treatment with E2 resulted in significantly less neuronal death in male but not female mice (40 ± 11 and 58 ± 6%, respectively). DPN treatment did not provide significant neuroprotection to either male or female mice (64 ± 4% and 52 ± 14%, respectively). Conclusions: Our findings suggest that E2-mediated protection in the juvenile brain after CA/CPR occurs via a different receptor than in the adult brain, and demonstrates gender specificity that is unique to this prepubertal population. We are now investigating the neuroprotective effects of other estrogen receptors, ER? and the non-classical ER GPR30 to determine the mechanism of E2 neuroprotection observed in juvenile males.
Examining the Frequency of Phlebotomy in Patients with Polycythemia Vera (PV) in the United States: An Analysis of Data from the REVEAL Study (2017)

Abstract Background:Phlebotomy is integral to the clinical management of patients with PV; however, it may be inconvenient and/or poorly tolerated. Frequent and long-term phlebotomies may cause iron deficiency, increased symptom burden, and lost productivity. This analysis from the Prospective Observational Study of Patients With PV in US Clinical Practices (REVEAL) describes the patient-reported burden of phlebotomies at enrollment and ≤6 months post-enrollment. Design: REVEAL is a prospective, observational study of patients aged ≥18 years with PV under physician supervision. Physician assessments and patient-reported outcomes are being collected every 3 months. Phlebotomy-related burden of patients is evaluated using the 21-item phlebotomy burden questionnaire (PBQ-21) administered every 3 months, assessing frequency, time needed, inconvenience, and phlebotomy-related adverse effects. Of the 2510 enrolled patients, 1173 had ≥1 phlebotomy within 3 months before enrollment and completed the PBQ-21 questionnaire. Phlebotomy-related effects and bother/inconvenience (≤24 hours following the procedure) are graded from 1 (not at all) to 4 (extremely). Findings: Median (range) age was 65 (22-95) years; patients were mostly male (61.0%) and white (91.2%). Median disease duration (PV diagnosis to enrollment) was 3.2 years (range, 0-39.2). At enrollment, newly diagnosed patients ( Conclusion: Patients with newly diagnosed PV experience a greater number of phlebotomies than those with a longer history of the disease. Irrespective of duration of disease, patients enrolled in REVEAL continued to receive phlebotomies at rate of approximately 8 phlebotomies per year. Patients reported spending a considerable amount of time undergoing phlebotomies and missing work. Patients continue to report distress, bother, and inconvenience due to phlebotomies. Implications: These findings provide healthcare professionals with important insight into the patient-reported burden of phlebotomy and may help guide individualized treatment decisions. Disclosures Boccia: Amgen: Honoraria, Speakers Bureau; Celgene: Honoraria, Speakers Bureau; Center for Cancer and Blood Disorders: Research Funding; Abbvie: Honoraria, Speakers Bureau; DSI: Honoraria, Speakers Bureau; Takeda: Honoraria, Speakers Bureau; Genentech: Honoraria, Speakers Bureau. Sanz-Altamira: Incyte Corporation: Research Funding. Khan: Incyte Corporation: Research Funding. Berenzon: Incyte Corporation: Research Funding. Friedman: Incyte Corporation: Research Funding. Naim: Incyte Corporation: Employment, Equity Ownership. Paranagama: Incyte Corporation: Employment, Equity Ownership. Mesa: Novartis Pharmaceuticals Corporation: Consultancy; Promedico: Research Funding; Ariad: Consultancy; Galena Biopharma, Inc.: Consultancy; Gilead Sciences, Inc.: Research Funding; CTI BioPharma Corp.: Research Funding; Celgene Corporation: Research Funding; Incyte Corporation: Research Funding.
Human Monoclonal Antibody: 2. Simultaneous Expression of IgG and IgM with Similar Binding Specificities by a Human Hybrid Clone (1987)

The human hybridoma clone JDB1 has been in continuous culture for over 40 months. This clone simultaneously produces both IgG and IgM. These two molecules have been separated and examined immunochemically. Both of the simultaneously secreted immunoglobulins contain lambda light chains. In addition, both of the antibodies react with breast cancer cells but not in an identical fashion. The implications of this multiple antibody response and the heterogeneity of tumor antigens is discussed.
Synthesis of potential antineoplastic agents. XX. Compounds related to the 3-o-nitrophenylhydrazone of isatin (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of potential antineoplastic agents. XX. Compounds related to the 3-o-nitrophenylhydrazone of isatinFrank D. PoppCite this: J. Med. Chem. 1969, 12, 1, 182–184Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/jm00301a054https://doi.org/10.1021/jm00301a054research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intracellular Signaling Events in CD77-Mediated Apoptosis of Burkitt's Lymphoma Cells (1997)

In the hematopoietic system CD77, a glycolipid surface antigen, is restricted to group I Burkitt's lymphoma (BL) cell lines and a subset of germinal center B lymphocytes. Recently, we have reported that recombinant B subunits of Verotoxin, which specifically binds to CD77, induce programmed cell death of CD77+ BL cells. Here, we show that an anti-CD77 monoclonal antibody (38.13) immobilized on tissue culture dishes also induces apoptosis, and we have explored the signal transducing events leading to this cell death. We show that ligation of CD77 antigen causes an increase of the intracellular Ca2+ concentration owing to an influx of extracellular Ca2+ through calcium channels. Chelation of extracellular Ca2+ with EGTA partially prevents anti-CD77-induced apoptosis, indicating that this process is probably Ca2+ dependent. We show that the cross-linking of CD77 provokes an increase of intracellular cAMP levels followed by cAMP-dependent protein kinase activation. We report that BL cells produce ceramide when they are exposed to 38.13 but, unexpectedly, without a concomitant decrease in sphingomyelin or CD77 content. Finally, we provide evidence that C2-ceramide, calcium ionophore, and forskolin (which increases intracellular levels of cAMP) independently induce apoptosis of CD77+ BL cells and, moreover, that C2-ceramide and forskolin strongly synergize to cause cell death. The possible role of CD77-mediated apoptosis in the B cell selection that occurs in germinal centers is discussed.
A novel zero-overlap/enclosure metal interconnection technology for high density logic VLSIs (2002)

A novel metal interconnection structure with self-defined metal overlap/enclosure of contact/via-hole technology utilizing polysilicon side-wall spacers and plug (SEMOCS) is proposed. It can realize a drastic reduction of metal pitch for high-density logic VLSIs. In addition, by applying a selective CVD-W technique to the via-hole filling, zero metal overlap of the via was also achieved. To verify the advantages of the technology, it was applied to a 32-b CMOS multiplier with triple-level metal interconnections. The chip area was reduced and higher-speed multiplication was achieved due to the reduction of parasitic capacitance resulting from the shrinkage of diffusion area and metal length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Video Based Reconstruction of 3D People Models (2018)

This paper describes a method to obtain accurate 3D body models and texture of arbitrary people from a single, monocular video in which a person is moving. Based on a parametric body model, we present a robust processing pipeline to infer 3D model shapes including clothed people with 4.5mm reconstruction accuracy. At the core of our approach is the transformation of dynamic body pose into a canonical frame of reference. Our main contribution is a method to transform the silhouette cones corresponding to dynamic human silhouettes to obtain a visual hull in a common reference frame. This enables efficient estimation of a consensus 3D shape, texture and implanted animation skeleton based on a large number of frames. Results on 4 different datasets demonstrate the effectiveness of our approach to produce accurate 3D models. Requiring only an RGB camera, our method enables everyone to create their own fully animatable digital double, e.g., for social VR applications or virtual try-on for online fashion shopping.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats (2012)

Physical and chemical constraints imposed by the periinfarct glial scar may contribute to the limited clinical improvement often observed after ischemic brain injury. To investigate the role of some of these mediators in outcome from cerebral ischemia, we treated rats with the growth-inhibitory chondroitin sulfate proteoglycan neurocan, the growth-stimulating heparan sulfate proteoglycan glypican, or the chondroitin sulfate proteoglycan-degrading enzyme chondroitinase ABC. Neurocan, glypican, or chondroitinase ABC was infused directly into the infarct cavity for 7 d, beginning 7 d after middle cerebral artery occlusion. Glypican and chondroitinase ABC reduced glial fibrillary acidic protein immunoreactivity and increased microtubule-associated protein-2 immunoreactivity in the periinfarct region, and glypican- and chondroitinase ABC-treated rats showed behavioral improvement compared with neurocan- or saline-treated rats. Glypican and chondroitinase ABC also increased neurite extension in cortical neuron cultures. Glypican increased fibroblast growth factor-2 expression and chondroitinase ABC increased brain-derived neurotrophic factor expression in these cultures, whereas no such effects were seen following neurocan treatment. Thus, treatment with glypican or enzymatic disruption of neurocan with chondroitinase ABC improves gross anatomical, histological, and functional outcome in the chronic phase of experimental stroke in rats. Changes in growth factor expression and neuritogenesis may help to mediate these effects.
Inhibitor of Apoptosis Proteins: Translating Basic Knowledge into Clinical Practice (2004)

The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has increased, the knowledge is being translated into clinically useful applications in the diagnosis and treatment of malignancy. For example, IAPs such as survivin are being investigated as diagnostic markers for the presence of occult malignancy. In addition, IAP overexpression is a poor prognostic marker in a variety of solid tumors and hematologic malignancies. Finally, IAPs are attractive therapeutic targets, and efforts are under way to develop antisense and chemical IAP inhibitors that may be useful for the treatment of a variety of malignancies. For all of these potential clinical applications, however, the challenge remains to incorporate these findings into actual clinical practice.
Effect of Chitosan-N-Acetylcysteine Conjugate in a Mouse Model of Botulinum Toxin B–Induced Dry Eye (2009)

Topically applied C-NAC might protect the ocular surface in dry eye syndrome, as evidenced by decreased inflammatory cytokine expression.
On SDM/WDM FBG sensor net for shape detection of endoscope (2006)

A novel slim FBG (fiber Bragg grating) sensor wire and its application in real-time dynamic shape detection of colonoscopes are presented. The SDIM/WDM (spatial division multiplex and wavelength division multiplex) sensing network is composed of 20 FBG sensors in four channels. The sensors are mounted on the body of a slim flexible wire, which can be inserted into the biopsy channel of a colonoscope. The FBG sensors are used to capture deformation of the sensor wire. A signal processing system and novel software are designed to reconstruct the shape of the colonoscope. Configuration of experimental system, experimental results and the temperature influence are also discussed.