gebhart/patrepeval huggingface dataset:
Enhanced Polarimetric Detection in HPLC Using a Refractive Index Equalizer (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnhanced Polarimetric Detection in HPLC Using a Refractive Index EqualizerFrancois. Maystre, Alfredo E. Bruno, Christian. Kuehner, and H. M. WidmerCite this: Anal. Chem. 1994, 66, 18, 2882–2887Publication Date (Print):September 15, 1994Publication History Published online1 May 2002Published inissue 15 September 1994https://doi.org/10.1021/ac00090a014RIGHTS & PERMISSIONSArticle Views141Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Visor-display design based on planar holographic optics (1995)

A method for designing and recording visor displays based on planar holographic optics is presented. This method can deal with the problem of recording-readout wavelength shift. The display system is composed of two holographic optical elements that are recorded on the same substrate. One element collimates the waves from each data point in the display into a plane wave that is trapped inside the substrate by total internal reflection. The other diffracts the plane waves into the eye of an observer. Because the chromatic dispersion of the first element can be corrected by the dispersion of the second, this configuration is relatively insensitive to source wavelength shifts. The method is illustrated by the design, recording, and testing of a compact holographic doublet visor display. The recording was at a wavelength of 458 nm, and readout was at 633 nm. The results indicate that diffraction-limited performance and relatively low chromatic dispersion over a wide field of view can be obtained.
Topical Methotrexate In Localized Psoriasis (2004)

A comparative study of topical methotrexate and topical tar in eighteen patients of localized psoriasis with bilateral involvement of both lower legs, equal in area and disease severity was carried out. The patients were asked to apply topical methorexate 0.25&#x0025; in a hydrophilic gel twice daily on right leg. The test sites were score, before therapy, after one month and after two months. The result with topical methotrexate preparation was promising but was comparable to topical tar formulation.
Ribozymes: A Distinct Class of Metalloenzymes (1993)

Ribozymes are an important new class of metalloenzymes that have an unlikely feature: they are made entirely of ribonucleic acid (RNA). Metal ions are essential for efficient chemical catalysis by ribozymes and are often required for the stabilization of ribozyme structure. Most ribozymes catalyze reactions at phosphorus centers through one of two major mechanistic pathways, and reaction has been observed at carbon centers. Creative experiments have revealed the position of metal ions in the active site of two ribozymes. The exploitation of variable metal geometry and reactivity has expanded ribozyme chemistry and has facilitated the application of in vitro selection for the creation of novel ribozymes.
Effect of Adjacent Layers on Crystallization and Magnetoresistance in CoFeB/MgO/CoFeB Magnetic Tunnel Junction (2006)

Crystallization must occur in order to obtain lattice matching between CoFeB and MgO in amorphous CoFeB/MgO/amorphous CoFeB magnetic tunnel junction (MTJ). However, the interface layer effect on the crystallization behavior is not yet clear. An aim of our experiments was to investigate the effects of various layers including Ta, MgO, Ru, and NiFe on the crystallization and transport properties in CoFeB/MgO/CoFeB MTJs deposited on SiO <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$_2$</tex> /Si and glass. It was found that the onset of crystallization of CoFeB and its specific orientation were dependent on the layer adjacent to CoFeB. The effects of crystallization on transport properties are also discussed.
Modification and fate of J chain in myeloma cells in the presence and absence of polymeric immunoglobulin secretion (1978)

Abstract Processing of J chain in various mouse myeloma cell lines was examined by incorporation of radioactive cystine, followed by analysis of proteins by immune precipitation and gel electrophoresis. J chain was synthesized by all myeloma‐derived cell lines examined, but not by nonmyeloma cell lines, even of B lymphocyte lineage. Secretion of J chain occurred only from cells secreting IgA or IgM. The J chain synthesized in other myeloma cell lines, was altered to a form that did not migrate at the rate of J chain during electrophoresis and was not recognized by the anti‐J chain antiserum. This alteration, probably due to degradation, occurred at a similar rate to the secretion of J chain by cell lines producing IgA or IgM. Some degradation of J chain may also occur in cell lines secreting J chain. Although the J chains from several cell lines were indistinguishable by gel electrophoresis when first synthesized, secreted J chains from three cell lines all showed slight differences in mobility both from one another and from intracellular J chain. The change in mobility occurred at or near the time of secretion of immunoglobulin, and was consistent with the addition of different amounts of carbohydrate to J chain in the three different myelomas.
Functional Interaction between T2R Taste Receptors and G-Protein α Subunits Expressed in Taste Receptor Cells (2003)

Bitter taste perception is a conserved chemical sense against the ingestion of poisonous substances in mammals. A multigene family of G-protein-coupled receptors, T2R (so-called TAS2R or TRB) receptors and a G-protein alpha subunit (Galpha), gustducin, are believed to be key molecules for its perception, but little is known about the molecular basis for its interaction. Here, we use a heterologous expression system to determine a specific domain of gustducin necessary for T2R coupling. Two chimeric Galpha16 proteins harboring 37 and 44 gustducin-specific sequences at their C termini (G16/gust37 and G16/gust44) responded to different T2R receptors with known ligands, but G16/gust 23, G16/gust11, and G16/gust5 did not. The former two chimeras contained a predicted beta6 sheet, an alpha5 helix, and an extreme C terminus of gustducin, and all the domains were indispensable to the expression of T2R activity. We also expressed G16 protein chimeras with the corresponding domain from other Galpha(i) proteins, cone-transducin (Galpha(t2)), Galpha(i2), and Galpha(z) (G16/t2, G16/i2, and G16/z). As a result, G16/t2 and G16/i2 produced specific responses of T2Rs, but G16/z did not. Because Galpha(t2) and Galpha(i2) are expressed in the taste receptor cells, these G-protein alpha(i) subunits may also be involved in bitter taste perception via T2R receptors. The present Galpha16-based chimeras could be useful tools to analyze the functions of many orphan G-protein-coupled taste receptors.
Schematic surface reconstruction (2012)

This paper introduces a schematic representation for architectural scenes together with robust algorithms for reconstruction from sparse 3D point cloud data. The schematic models architecture as a network of transport curves, approximating a floorplan, with associated profile curves, together comprising an interconnected set of swept surfaces. The representation is extremely concise, composed of a handful of planar curves, and easily interpretable by humans. The approach also provides a principled mechanism for interpolating a dense surface, and enables filling in holes in the data, by means of a pipeline that employs a global optimization over all parameters. By incorporating a displacement map on top of the schematic surface, it is possible to recover fine details. Experiments show the ability to reconstruct extremely clean and simple models from sparse structure-from-motion point clouds of complex architectural scenes.
A Chimeric Respiratory Syncytial Virus Fusion Protein Functionally Replaces the F and HN Glycoproteins in Recombinant Sendai Virus (2005)

Entry of most paramyxoviruses is accomplished by separate attachment and fusion proteins that function in a cooperative manner. Because of this close interdependence, it was not possible with most paramyxoviruses to replace either of the two protagonists by envelope glycoproteins from related paramyxoviruses. By using reverse genetics of Sendai virus (SeV), we demonstrate that chimeric respiratory syncytial virus (RSV) fusion proteins containing either the cytoplasmic domain of the SeV fusion protein or in addition the transmembrane domain were efficiently incorporated into SeV particles provided the homotypic SeV-F was deleted. In the presence of SeV-F, the chimeric glycoproteins were incorporated with significantly lower efficiency, indicating that determinants in the SeV-F ectodomain exist that contribute to glycoprotein uptake. Recombinant SeV in which the homotypic fusion protein was replaced with chimeric RSV fusion protein replicated in a trypsin-independent manner and was neutralized by antibodies directed to RSV-F. However, replication of this virus also relied on the hemagglutinin-neuraminidase (HN) as pretreatment of cells with neuraminidase significantly reduced the infection rate. Finally, recombinant SeV was generated with chimeric RSV-F as the only envelope glycoprotein. This virus was not neutralized by antibodies to SeV and did not use sialic acids for attachment. It replicated more slowly than hybrid virus containing HN and produced lower virus titers. Thus, on the one hand RSV-F can mediate infection in an autonomous way while on the other hand it accepts support by a heterologous attachment protein.
Polymorphism in the interferon-alpha gene family. (1996)

A pronounced genetic polymorphism of the interferon type I gene family has been assumed on the basis of RFLP analysis of the genomic region as well as the large number of sequences published compared to the number of loci. However, IFNA2 is the only locus that has been carefully analyzed concerning gene frequency, and only naturally occurring rare alleles have been found. We have extended the studies on a variation of expressed sequences by studying the IFNA1, IFNA2, IFNA10, IFNA13, IFNA14, and IFNA17 genes. Genomic white-blood-cell DNA from a population sample of blood donors and from a family material were screened by single-nucleotide primer extension (allele-specific primer extension) of PCR fragments. Because of sequence similarities, in some cases "nested" PCR was used, and, when applicable, restriction analysis or control sequencing was performed. All individuals carried the interferon-alpha 1 and interferon-alpha 13 variants but not the LeIF D variant. At the IFNA2 and IFNA14 loci only one sequence variant was found, while in the IFNA10 and IFNA17 groups two alleles were detected in each group. The IFNA10 and IFNA17 alleles segregated in families and showed a close fit to the Hardy-Weinberg equilibrium. There was a significant linkage disequilibrium between IFNA10 and IFNA17 alleles. The fact that the extent of genetic polymorphism was lower than expected suggests that a majority of the previously described gene sequences represent nonpolymorphic rare mutants that may have arisen in tumor cell lines.
Using F-formations to analyse spatial patterns of interaction in physical environments (2011)

There are few conceptual tools available to analyse physical spaces in terms of their support for social interactions and their potential for technological augmentation. In this paper, we describe how we used Adam Kendon's characterisation of the F-formation system of spatial organisation as a conceptual lens to analyse the social interactions between visitors and staff in a tourist information centre. We describe how the physical structures in the space encouraged and discouraged particular kinds of interactions and discuss how F-formations might be used to think about augmenting physical spaces.
Tocilizumab for Giant Cell Arteritis—A New Giant Step in an Old Disease (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION (2007)

Bacillus anthracis (anthrax) can trigger an acute inflammatory response that results in multisystem organ failure and death. Previously, we developed a mathematical model of acute inflammation after gram-negative infection that had been matched qualitatively to literature data. We modified the properties of the invading bacteria in that model to those specific to B. anthracis and simulated the host response to anthrax infection. We simulated treatment strategies against anthrax in a genetically diverse population including the following: (1) antibiotic treatment initiated at various time points, (2) antiprotective antigen vaccine, and (3) a combination of antibiotics and vaccine. In agreement with studies in mice, our simulations showed that antibiotics only improve survival if administered early in the course of anthrax infection. Vaccination that leads to the formation of antibodies to protective antigen is anti-inflammatory and beneficial in averting shock and improving survival. However, antibodies to protective antigen alone are predicted not to be universally protective against anthrax infection. Rather, our simulations suggest that an optimal strategy would require both vaccination and antibiotic administration.
Understanding video : applications, impact, and theory (1987)

PART ONE: VIDEO AS VISUAL COMMUNICATION The Development as Video The Characteristics of Video Perceiving the Image PART TWO: APPLICATIONS OF VIDEO Extensions and Expressions Using Video Experiencing New Video Forms The Economics of Communicating Through Video Forms PART THREE: DEVELOPING A THEORY OF VIDEO COMMUNICATION Extending Video Communication to Social Experience Toward a Theory of Video Communication
Potential Role of Ginseng in the Treatment of Colorectal Cancer (2008)

Colorectal cancer remains one of the most prevalent cancer and a leading cause of cancer related death in the US. Many currently used chemotherapeutic agents are derived from botanicals. Identifying herbal sources, including those from ginseng family, to develop better anti-cancer therapies remains an essential step in advancing the treatment of the cancer. In this article, potential roles of ginseng herbs, especially American ginseng and notoginseng, in colorectal cancer therapeutics are presented. The major pharmacologically active constituents of ginsengs are ginsenosides, which can be mainly classified as protopanaxadiol and protopanaxatriol groups. Structure-activity relationship between their chemical structures and pharmacological activities are discussed. In addition, various steaming temperature and time treatment of the ginseng herbs can change ginsenoside profiles, and enhance their anti-cancer activities. This heat treatment process may increase the role of ginseng in treating colorectal cancer.
The Real Estate Brokerage Industry and Antitrust Implications (1981)

First quarter reports of 1980 evidenced a drop of new housing starts by 22%. 4. The federal antitrust statutes are found in three main acts: the Sherman Act, ch.647, 26 Stat.209; the Clayton Act, ch.323, 38 Stat.730 (current version at 15objectives of which are to assure a competitive economy."From the very beginning, antitrust ... was considered a bulwark against arbitrary action and oppression at the hands of the economically powerful ... ."5The underlying theory is that through a truly competitive marketplace, the lowest price will be found for goods to satisfy consumer wants while, at the same time, preserving scarce resources as best as possible.Such a system suggests that the "consumer (through his willingness or refusal to buy) will decide what and how much shall be produced and that competition among producers (with the production of the highest quality product at the lowest price) will determine who will manufacture it."6It would appear that this economic goal is somewhat thwarted when the providers of services who are supposed U.S.C. 12-27, 44 (1976) with particular provisions often identified themselves for the specific area of antitrust activity codified: the Robinson-Patman Act, ch.592,
A role for lipid droplets in inter‐membrane lipid traffic (2009)

All cells have the capacity to accumulate neutral lipids and package them into lipid droplets. Recent proteomic analyses indicate that lipid droplets are not simple lipid storage depots, but rather complex organelles that have multiple cellular functions. One of these proposed functions is to distribute neutral lipids as well as phospholipids to various membrane-bound organelles within the cell. Here, we summarize the lipid droplet-associated membrane-trafficking proteins and review the evidence that lipid droplets interact with endoplasmic reticulum, endosomes, peroxisomes, and mitochondria. Based on this evidence, we present a model for how lipid droplets can distribute lipids to specific membrane compartments.
State of Charge Estimation of Lithium-Ion Batteries in Electric Drive Vehicles Using Extended Kalman Filtering (2012)

A more accurate battery state of charge (SOC) estimation method for electric drive vehicles is developed based on a nonlinear battery model and an extended Kalman filter (EKF) supported by experimental data. A nonlinear battery model is constructed by separating the model into a nonlinear open circuit voltage and a two-order resistance-capacitance model. EKF is used to eliminate the measurement and process noise and remove the need of prior knowledge of initial SOC. A hardware-in-the-loop test bench was built to validate the method. The experimental results show that the proposed method can estimate the battery SOC with high accuracy.
Single‐agent lenalidomide in relapsed/refractory mantle cell lymphoma: results from a UK phase II study suggest activity and possible gender differences (2012)

We present data from a phase II study investigating a novel treatment strategy for relapsed/refractory mantle cell lymphoma (MCL). Twenty-six patients received lenalidomide 25 mg/d (days 1-21 of a 28-d cycle) for up to 6 cycles followed by low-dose maintenance lenalidomide (15 mg) in responding patients. Eight patients achieved complete or partial response to give an overall response rate of 31% with median response duration of 22·2 months [95% confidence interval (CI) 0·0-53·6] and median progression-free survival (PFS) of 3·9 months (95% CI 0·0-11·1). An additional six patients (23%) achieved stable disease. Eleven patients received maintenance with median PFS of 14·6 months (95% CI 7·3-21·9). Correlative studies showed that peripheral T and Natural Killer (NK) cells increased in responding patients by 40-60% over the first 6 cycles with an initial dip in NK cells suggestive of tumour infiltration. Peripheral regulatory T cells were increased in MCL patients (P = 0·001) and expanded further following lenalidomide. Sequential plasma analysis showed increased IL12 p40 and IL7 alongside decreased MMP9, IL10, and adiponectin. Finally, a significant correlation (P = 0·02) between gender and response suggested that female MCL patients were more sensitive to lenalidomide than males. In summary, we confirm the activity, safety and immunomodulatory properties of lenalidomide in MCL and highlight its potential as a low-dose maintenance agent.
Interaction-driven speech input (1998)

article Free Access Share on Interaction-driven speech input: a data-driven approach to the capture of both local and global language constraints Author: Jerome R. Bellegarda View Profile Authors Info & Claims ACM SIGCHI BulletinVolume 30Issue 2April 1998 pp 102–105https://doi.org/10.1145/279044.279168Online:01 April 1998Publication History 0citation86DownloadsMetricsTotal Citations0Total Downloads86Last 12 Months19Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
In vitroandIn vivoCharacterization of MDX-1401 for Therapy of Malignant Lymphoma (2009)

The low doses of antibody required for ADCC activity irrespective of donor genotype, the ability to mediate ADCC in target cells expressing low levels of CD30, and increased in vivo efficacy support the development of MDX-1401 for treatment of malignant lymphoma.
Digital expression profiles of human endogenous retroviral families in normal and cancerous tissues. (2004)

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections that became fixed in the germ line DNA millions of years ago. The fact that humoral and cellular immune responses against HERV-encoded proteins have been identified in cancer patients suggests that these antigens might be used in cancer immunotherapy or diagnosis. We analyzed the digital expression patterns of the HERV-K (HML-2), -W, -H and -E families in normal and cancerous tissues. Thirty-one proviral members of the HERV-K family and one representative each for the other HERV families were used as probes to search human EST data. Matching of HERV proviruses to ESTs was HERV family-specific and the expression profiles of the HERV families distinct. The HERV-K family was expressed in normal tissues such as muscle, skin and brain, as well as in germ cell tumors and other cancerous tissues. HERV-H was the only family expressed in cancers of the intestine, bone marrow, bladder and cervix, and was more highly expressed than the other families in cancers of the stomach, colon and prostate. In contrast, HERV-W was predominantly expressed in normal placenta. Expression patterns were confirmed by MPSS (massively parallel signature sequencing) data where available. For the HERV-K family, we mapped most ESTs to their corresponding proviruses and assessed the coding capacities of the matched proviruses. This study shows that HERV families are more widely expressed than originally thought and that some members of the HERV-K and -H families could encode targets for cancer immunotherapy.