gebhart/patrepeval huggingface dataset:
A Spike and Slab Restricted Boltzmann Machine (2011)

We introduce the spike and slab Restricted Boltzmann Machine, characterized by having both a real-valued vector, the slab, and a binary variable, the spike, associated with each unit in the hidden layer. The model possesses some practical properties such as being amenable to Block Gibbs sampling as well as being capable of generating similar latent representations of the data to the recently introduced mean and covariance Restricted Boltzmann Machine. We illustrate how the spike and slab Restricted Boltzmann Machine achieves competitive performance on the CIFAR-10 object recognition task.
Effective Use of Donor MHC Class I Gene Therapy in Organ Transplantation: Prevention of Antibody-Mediated Hyperacute Heart Allograft Rejection in Highly Sensitized Rat Recipients (2000)

Immunologically sensitized recipients present one of the most critical problems in clinical organ transplantation today, since preformed antibodies rapidly destroy donor tissue expressing specific MHC class I antigens (Ag). Therefore, sensitized patients are either unable to receive a compatible organ, or experience a prolonged waiting period. In this study we examined the effectiveness of donor MHC class I gene therapy in preventing hyperacute rejection (HR) of rat heart allografts in passively sensitized recipients. Our gene therapy strategy to address this problem is based on the phenomenon that liver transplants, which resist antibody-mediated HR, produce soluble MHC class I Ag capable of neutralizing preformed antibodies and suppressing the immune response. To mimic this "liver effect," we used liposomes to transfect cultured recipient (Lewis-RT1.Al) hepatocytes with plasmid DNA encoding the soluble donor MHC class I Ag, RT1.Aa. Control or RT1.Aa-transfected hepatocytes were implanted intrasplenically into Lewis recipients 1 day prior to heterotopic ACI (RT1.Aa) heart transplantation and injection of 6 ml of anti-ACI hyperimmune serum (HIS). Results showed that nearly all recipients receiving ACI-specific HIS and control hepatocytes experienced HR, while none of the recipients receiving HIS and hepatocytes expressing soluble RT1.Aa developed HR. Furthermore, active immunosuppression by soluble RT1.Aa was evidenced by prolongation of allograft survival, compared with controls not receiving HIS. In summary, soluble donor-MHC class I Ag gene therapy can prevent antibody-mediated destruction associated with HR. Future development of a similar strategy in humans may significantly improve the results of clinical organ transplantation in immunologically sensitized recipients.
The systemic inflammatory response syndrome: definitions and aetiology (1998)

Systemic inflammatory response syndrome (SIRS) is the clinical expression of the action of complex intrinsic mediators of the acute phase reaction. SIRS can be precipitated by events such as infection, trauma, pancreatitis, and surgery. At times, SIRS can compromise the function of various organ systems resulting in Multiple Organ Dysfunction Syndrome (MODS). SIRS and MODS are graded expressions of the inflammation associated with acute illness. Mild forms are frequent in general wards for both medical and surgical patients but those with severe forms require intensive care. Clinicians should learn to identify SIRS in their patients at an early stage to determine the underlying cause and treatment before the SIRS progresses to a more severe form.
Device Requirements for Optical Interconnects to Silicon Chips (2009)

We examine the current performance and future demands of interconnects to and on silicon chips. We compare electrical and optical interconnects and project the requirements for optoelectronic and optical devices if optics is to solve the major problems of interconnects for future high-performance silicon chips. Optics has potential benefits in interconnect density, energy, and timing. The necessity of low interconnect energy imposes low limits especially on the energy of the optical output devices, with a ~ 10 fJ/bit device energy target emerging. Some optical modulators and radical laser approaches may meet this requirement. Low (e.g., a few femtofarads or less) photodetector capacitance is important. Very compact wavelength splitters are essential for connecting the information to fibers. Dense waveguides are necessary on-chip or on boards for guided wave optical approaches, especially if very high clock rates or dense wavelength-division multiplexing (WDM) is to be avoided. Free-space optics potentially can handle the necessary bandwidths even without fast clocks or WDM. With such technology, however, optics may enable the continued scaling of interconnect capacity required by future chips.
The Leishmaniases (1974)

The leishmaniases form a constellation of diseases resulting from invasion of the reticuloendothelial (or, lymphoid-macrophage) system of a vertebrate host by hemoflagellates of the genus Leishmania. Ordinarily, the parasites are transmitted by the bite of a small, hairy sandfly of the family Phlebotomidae, in which there is a developmental cycle in the mid-gut. Multiplication of parasites at intracellular sites ordinarily begins around the site of the original infection. There may be limitation of the organisms to that area, or may metastasize to other locations in the lymphoid-macrophage system. Clinical manifestations of diverse character result from such infections, as indicated by the terms cutaneous, muco-cutaneous, and visceral leishmaniasis. The taxonomy of the Leishmania has posed numerous and complex problems, and strains or demes of the organisms may alter response of the patient to both the parasites and to agents used in treatment of the leishmaniases.
Lymphoma Diagnosis and Plasma Epstein‐Barr Virus Load during Vicriviroc Therapy: Results of the AIDS Clinical Trials Group A5211 (2009)

CCR5 antagonism by vicriviroc treatment in treatment-experienced patients was not associated with reactivation of EBV infection.
Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A (1995)

Polyomavirus middle T antigen (MT) is the major transforming protein of the virus. It functions through interactions with a number of cellular proteins involved in cell proliferation. MT forms complexes with protein phosphatase 2A (PP2A), pp60c-src, phosphatidylinositol 3-kinase, and Shc. We introduced both deletion and point mutations into three regions of MT and examined their ability to associate with PP2A and pp60c-src. The first 25 amino acid residues of MT are required for association with PP2A and pp60c-src. Amino acids 105 to 111, comprising the sequence Cys-Arg-Met-Pro-Leu-Thr-Cys, is also required for complex formation between MT and PP2A. However, the sequence Asp-Lys-Gly-Gly (amino acids 44 to 47), also found in the B subunit of PP2A, is dispensable for complex formation between MT and PP2A. We find a strict correlation between the ability of MT to associate with PP2A and the ability of MT to associate with pp60c-src. One mutant, L5E, associates with a phosphatase other than PP2A, pp60c-src, and phosphatidylinositol 3-kinase in a manner similar to that of wild-type MT yet is reduced in its transforming ability on NIH 3T3 cells.
Factors that bind to adeno-associated virus terminal repeats (1989)

We have identified and characterized a DNA-protein complex that forms with the adeno-associated virus (AAV) terminal repeats. The complex formed only if the terminal palindrome was in the covalently closed or hairpin configuration; little if any binding was detected with the open duplex form of the terminal repeat. This fact suggested that both secondary structure and primary sequence are essential elements of recognition. DNase I protection studies indicated that virtually all of the A-A' palindrome and significant portions of the B-B' and C-C' palindromes are protected. The postulated terminal resolution site of AAV also is protected. Restriction mapping of the sequences necessary for binding indicated that almost all of the terminal palindrome must be present for binding to occur. Hairpins which are similar in size and shape to the AAV termini did not exhibit competition for binding, and the complex formed only if AAV-infected extracts were used. Thus, the binding reaction is specific for AAV sequences. The viral-coded nonstructural proteins Rep78 and Rep68 comigrated with the DNA-protein complex on neutral acrylamide gels, suggesting that one or both of these proteins are components of the complex. The characteristics of the complex suggested that it has a role in AAV DNA replication.
Quadrotor analysis and model free control with comparisons (2013)

Inspired by the limitations of traditional PID controllers and the different performance in ideal and realistic cases, the existing quadrotors, their applications and control methods have been intensively studied in this dissertation. Many challenges are shown: embedded quadrotor systems have limit computational resources and energy; the aerodynamic dynamics is rather complex and poorly known; environment has many disturbances and uncertainties; many control methods have been proposed in ideal scenarios in literature without comparison. Therefore, this dissertation focuses on these main points in control of quadrotors.A kinematic model and a dynamic model are proposed, including all the important aerodynamic forces and moments. A simplified dynamic model is also given based on some applications. Then, the dynamics of quadrotor is analyzed. Using the normal form theory, the model of quadrotor is simplified to a simplest form named the normal form, which exhibits all possible dynamic properties of the original system. The bifurcations of its normal form are then studied, and the system can be further simplified at its bifurcation point using the center manifold theory.Based on the research of the applications in the first chapter, five typical realistic scenarios are proposed: an ideal case, the cases with wind disturbance, parameter uncertainties, sensor noises and actuator faults. These realistic cases can show comprehensively the performance of control methods respect to the ideal cases. An event triggered scheme is also proposed with the time triggered scheme in order to further save computational resources. Then, a newly proposed method the model free control is presented. It is a simple but efficient technique for the nonlinear, unknown or partially known dynamics. A backstepping control and a sliding mode control are also proposed for the sake of comparison.All the control methods are implemented in the time and event triggered schemes in five different scenarios. In order to keep closer to realistic situations, the control gains of each methods are not changed in different scenarios. Based on the study in the first chapter, ten criteria are chosen for measuring the performance of control methods, such as the maximum absolute tracking error, the error variance, the actuation steps, the energy consumption, etc.
A Tale of Two Sites: On Defining the Carrier Concentration in Garnet‐Based Ionic Conductors for Advanced Li Batteries (2015)

Solid electrolytes based on the garnet crystal structure have recently been identified as a promising material to enable advance Li battery cell chemistries because of the unprecedented combination of high ionic conductivity and electrochemical stability against metallic Li. To better understand the mechanisms that give rise to high conductivity, the goal of this work is to correlate Li site occupancy with Li‐ion transport. Toward this goal, the Li site occupancy is studied in cubic garnet as a function of Li concentration over the compositions range: Li 7− x La 3 Zr 2− x Ta x O 12 ( x = 0.5, 0.75, and 1.5). The distribution of Li between the two interstitial sites (24d and 96h) is determined using neutron and synchrotron diffraction. The bulk conductivity is measured on &gt;97% relative density polycrystalline specimens to correlate Li‐ion transport as a function of Li site occupancy. It is determined that the conductivity changes nonlinearly with the occupancy of the octahedral (96h) Li site. It is shown that the effective carrier concentration is dependent on the Li site occupancy and suggests that this is a consequence of significant carrier–carrier coulombic interactions. Furthermore, the observation of maximum conductivity near Li = 6.5 mol is explained.
Electrochemical determination of the ionization potential and electron affinity of poly(9,9-dioctylfluorene) (1998)

We report cyclic voltammetry measurements for the blue electroluminescent conjugated polymer poly(9,9-dioctylfluorene). Both oxidation and reduction potentials are determined and thus estimates of both the ionization potential Ip and electron affinity Ea of the polymer are obtained for the same sample under the same experimental conditions. We estimate Ip=5.80 eV and Ea=2.12 eV. These results disagree with the common assumption that Ea is, to good approximation, given by the difference between Ip and the optical gap. Measurements on indium tin oxide/polyfluorene/calcium light emitting diode structures are consistent with the deductions from the electrochemical data.
Overview of Allison/AGTSR interactions (1995)

Morgantown Energy Technology Center`s Tom Bechtel`s perseverance resulted in the creation of the Advanced Gas Turbine Systems Research (AGTSR) initiative in 1992. His foresight resulted in establishing an advanced gas turbine research center. The center is supported by the Government and industry. The industry serves in an oversight role, and helps select the type of research projects to be conducted by universities. AGTSR now represents an effective university and industry partnership, and is recognized as a positive mechanism. Allison Engine Company (Allison) continues to be an active participant and a strong supporter of the Advanced Gas Turbine Systems Research initiative at Clemson University. Allison took part in early formulation stages of this university/industry consortium. We have been a member of the consortium since its inception in 1992. Allison`s senior management is cognizant of the benefits of these jointly sponsored research programs. Over the years, Allison has promoted cooperative gas turbine research and advanced technology development at many universities. This activity is conducted through direct assignments at Allison for university students, and support of research projects at various universities, focused on different disciplines of gas turbine research.
Are Stressful Life Events Risk Factors for Herpes Zoster? (1990)

To determine if psychologically stressful life events are risk factors for herpes zoster, we conducted a case-control study of zoster and self-reported recent negative life events and major changes in spousal relationships. The subjects were 101 healthy community-dwelling cases of zoster and 101 healthy controls matched for age, sex, and race and generated by random digit dialing. The Geriatric Scale of Recent Life Events was administered to case and control subjects, and additional questions were asked regarding the perception of the life event. The results showed that case subjects experienced negative life events significantly more often than subjects in the control groups in the 2 months before zoster onset by analysis of discordant pairs (26 versus 10, odds ratio 2.60, 95% confidence interval [CI] 1.13, 6.27, P = .012), 3 months before (29 versus 11, odds ratio 2.64, 95% CI 1.20, 6.04, P = .007), or 6 months before (35 versus 16, odds ratio 2.00, 95% CI 1.04, 3.93, P = .012). The mean number of total life events was significantly higher in cases at 6 months before zoster (case means = 2.64, control means = 1.82, P = .008), but there were no significant differences at 2, 3, or 12 months before. There were no significant differences between case subjects and control subjects for spousal events, or any given single life event. In conclusion, we found that whereas patients with herpes zoster experienced the same kinds of life events in the year preceding the illness as did control subjects, recent events perceived as stressful were significantly more common among patients with zoster.(ABSTRACT TRUNCATED AT 250 WORDS)
Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells (1991)

We have used site-directed insertion and point mutagenesis in an attempt to increase the cytotoxic potency and receptor-binding affinity of the diphtheria-toxin-related interleukin-2 (IL-2) fusion toxins. Previous studies have demonstrated that both the DAB486-IL-2 and DAB389-IL-2 forms of the fusion toxin consist of three functional domains: the N-terminal fragment-A-associated ADP-ribosyltransferase, the hydrophobic-membrane-associating domains, and the C-terminal receptor-binding domain of human IL-2. By insertion mutagenesis we have increased the apparent flexibility of the polypeptide chain between the membrane-associating domains and the receptor-binding domain of this fusion toxin. In comparison to DAB486-IL-2, the cytotoxic potency of the insertion mutants was increased by approximately 17-fold for high-affinity IL-2-receptor-bearing cell lines in vitro. Moreover, competitive displacement experiments using [125I]rIL-2 demonstrate that the increase in cytotoxic potency correlates with an increase in receptor-binding affinity for both the high and intermediate forms of the IL-2 receptor.
Photoinduced Insulator-to-Metal Transition in a Perovskite Manganite (1997)

We have observed an insulator-to-metal (I-M) transition triggered by the photocarrier injection into the charge-ordered (CO) state of a perovskite manganite crystal, ${\mathrm{Pr}}_{0.7}{\mathrm{Ca}}_{0.3}{\mathrm{MnO}}_{3}$. The photocurrent is a highly nonlinear function of applied electric field and of light intensity; both show a threshold behavior for the I-M transition. The dependence of the anomalous photocurrent on the excitation photon energy and the temperature excludes the laser heating as the cause of the effect, suggesting the photocarrier-mediated collapse of the CO state.
PDL1 Regulation by p53 via miR-34 (2015)

We identified a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis. Our results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer.
Mechanisms which contribute to the long‐term survival of spores of Bacillus species (1994)

Journal Article Mechanisms which contribute to the long‐term survival of spores of Bacillus species Get access P. Setlow P. Setlow Department of Biochemistry, University of Connecticut Health Center, Farmington, CT, USA Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030‐3305, USA. Search for other works by this author on: Oxford Academic Google Scholar Journal of Applied Bacteriology, Volume 76, Issue S23, 1 June 1994, Pages 49S–60S, https://doi.org/10.1111/j.1365-2672.1994.tb04357.x Published: 01 June 1994
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. (1995)

Glycosaminoglycan-modified isoforms of CD44 have been implicated in growth factor presentation at sites of inflammation. In the present study we show that COS cell transfectants expressing CD44 isoforms containing the alternatively spliced exon V3 are modified with heparan sulfate (HS). Binding studies with three HS-binding growth factors, basic-fibroblast growth factor (b-FGF), heparin binding-epidermal growth factor (HB-EGF), and amphiregulin, showed that the HS-modified CD44 isoforms are able to bind to b-FGF and HB-EGF, but not AR. b-FGF and HB-EGF binding to HS-modified CD44 was eliminated by pretreating the protein with heparitinase or by blocking with free heparin. HS-modified CD44 immunoprecipitated from keratinocytes, which express a CD44 isoform containing V3, also bound to b-FGF. We examined whether HS-modified CD44 isoforms were expressed by activated endothelial cells where they might present HS-binding growth factors to leukocytes during an inflammatory response. PCR and antibody-binding studies showed that activated cultured endothelial cells only express the CD44H isoform which does not contain any of the variably spliced exons including V3. Immunohistological studies with antibodies directed to CD44 extracellular domains encoded by the variably spliced exons showed that vascular endothelial cells in inflamed skin tissue sections do not express CD44 spliced variants. Keratinocytes, monocytes, and dendritic cells in the same specimens were found to express variably spliced CD44. 35SO4(-2)-labeling experiments demonstrated that activated cultured endothelial cells do not express detectable levels of chondroitin sulfate or HS-modified CD44. Our results suggest that one of the functions of CD44 isoforms expressing V3 is to bind and present a subset of HS-binding proteins. Furthermore, it is probable that HS-modified CD44 is involved in the presentation of HS-binding proteins by keratinocytes in inflamed skin. However, our data suggests that CD44 is not likely to be the proteoglycan principally involved in presenting HS-binding growth factors to leukocytes on the vascular cell wall.
Enhanced leg exercise endurance with a high-carbohydrate diet and dihydroxyacetone and pyruvate (1990)

The effects of dietary supplementation of dihydroxyacetone and pyruvate (DHAP) on metabolic responses and endurance capacity during leg exercise were determined in eight untrained males (20-30 yr). During the 7 days before exercise, a high-carbohydrate diet was consumed (70% carbohydrate, 18% protein, 12% fat; 35 kcal/kg body weight). One hundred grams of either Polycose (placebo) or dihydroxyacetone and pyruvate (treatment, 3:1) were substituted for a portion of carbohydrate. Dietary conditions were randomized, and subjects consumed each diet separated by 7-14 days. After each diet, cycle ergometer exercise (70% of peak oxygen consumption) was performed to exhaustion. Biopsy of the vastus lateralis muscle was obtained before and after exercise. Blood samples were drawn through radial artery and femoral vein catheters at rest, after 30 min of exercise, and at exercise termination. Leg endurance was 66 +/- 4 and 79 +/- 2 min after placebo and DHAP, respectively (P less than 0.01). Muscle glycogen at rest and exhaustion did not differ between diets. Whole leg arteriovenous glucose difference was greater (P less than 0.05) for DHAP than for placebo at rest (0.36 +/- 0.05 vs. 0.19 +/- 0.07 mM) and after 30 min of exercise (1.06 +/- 0.14 vs. 0.65 +/- 0.10 mM) but did not differ at exhaustion. Plasma free fatty acids, glycerol, and beta-hydroxybutyrate were similar during rest and exercise for both diets. Estimated total glucose oxidation during exercise was 165 +/- 17 and 203 +/- 15 g after placebo and DHAP, respectively (P less than 0.05). It is concluded that feeding of DHAP for 7 days in conjunction with a high carbohydrate diet enhances leg exercise endurance capacity by increasing glucose extraction by muscle.