gebhart/patrepeval huggingface dataset:
A 0.4-μm CMOS 10-Gb/s 4-PAM pre-emphasis serial link transmitter (1999)

A serial link transmitter fabricated in a large-scale integrated 0.4-/spl mu/m CMOS process uses multilevel signaling (4-PBM) and a three-tap pre-emphasis filter to reduce intersymbol interference (ISI) caused by channel low-pass effects. Due to the process-limited on-chip frequency, the transmitter output driver is designed as a 5:1 multiplexer to reduce the required clock frequency to one-fifth the symbol rate, or 1 GHz. At 5 Gsym/s (10 Gbis), a data eye opening with a height >350 mV and a width >100 ps is achieved at the source. After 10 m of a copper coaxial cable (PE142LL), the eye opening is reduced to 200 mV and 90 ps with pre-emphasis, and to zero without filtering, The chip dissipates 1 W with a 3.3-V supply and occupies 1.5/spl times/2.0 mm/sup 2/ of die area.
A new male-sterile strain in Wabash soybeans (1977)

Journal Article A new male-sterile strain in Wabash soybeans Get access H. K. CHAUDHARI, H. K. CHAUDHARI Assistant professor Norfolk State CollegeNorfolk, VA 23504 Search for other works by this author on: Oxford Academic PubMed Google Scholar W. H. DAVIS W. H. DAVIS Soybean breeder Ring Around Products, Inc., Research DivisionPlainview, TX 79072 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 68, Issue 4, July 1977, Pages 266–267, https://doi.org/10.1093/oxfordjournals.jhered.a108831 Published: 01 July 1977
Factors underlying the cell growth-related bystander responses to alpha particles. (2000)

Increases in cell proliferation are widely viewed as being of importance in carcinogenesis. We report that exposure of normal human lung fibroblasts to a low dose of alpha particles like those emitted by radon/radon progeny stimulates their proliferation in vitro, and this response also occurs when unirradiated cells are treated with supernatants from alpha-irradiated cells. We attribute the promitogenic response to superoxide dismutase- and catalase-inhibitable a particle-induced increases in the concentrations of transforming growth factor beta1 (TGF-beta1) in cell supernatants. TGF-beta1 at concentrations commensurate with those in the supernatants capably induces increases in intracellular reactive oxygen species (ROS) in unirradiated cells. Furthermore, the addition of supernatants from alpha-irradiated cells to unirradiated cells decreases cellular levels of TP53 and CDKN1A and increases CDC2 and proliferating cell nuclear antigen in the latter. Like the increased intracellular ROS bystander effect, this "decreased TP53/CDKN1A response" can be mimicked in otherwise untreated cells by the addition of low concentrations of TGF-beta1. Our results indicate that alpha particle-associated increases in cell growth correlate with intracellular increases in ROS along with decreases in TP53 and CDKN1A, and that these cellular responses are mechanistically coupled. As well, the proliferating cell nuclear antigen and CDC2 increases that occur along with the decreased TP53/CDKN1A bystander effect also would expectedly favor enhanced cell growth. Such processes may account for cell hyperplastic responses in the conducting airways of the lower respiratory track that occur after inhalation exposure to radon/ radon progeny, as well as, perhaps, other ROS-associated environmental stresses.
INTERACTION OF PROJECTILES AND COMPOSITE ARMOR. PART II (1969)

Abstract : This report describes basic experimental and theoretical investigations of the interaction of projectiles and lightweight armor. The armor of interest is a very hard and relatively inflexible facing plate (ceramic) bonded to a flexible backing plate (fiber glass or aluminum alloy). The theoretical work concerns: (1) development of an analytical model for describing the restraining mechanisms of the armor and for prediction of ballistic limits, (2) checkout and use of a simple computer code for obtaining stress fields in brittle facing plates and projectiles caused by impact at normal incidence. The experimental work concerns: (1) the use of high-speed photography and flash X-ray techniques for specific investigations such as observing fracture conoids in facing plates, (2) demonstrating that stresses in ceramic facing plates can be measured by manganin stress gages.
Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin. (1988)

The action of inositol 1,4,5-trisphosphate (InsP3) in releasing intracellular Ca2+ is shown to be competitively and potently antagonized by the glycosaminoglycan, heparin. Using either permeabilized cells of the DDT1MF-2 smooth muscle cell line, or an isolated microsomal membrane fraction derived from intact cells, heparin (4-6 kDa) at 10 micrograms/ml was observed to completely block the action of InsP3 in releasing Ca2+ accumulated via the ATP-dependent Ca2+ pump. In permeabilized cells, heparin had no effect on Ca2+ pump activity or on passive Ca2+ fluxes contributing to equilibrium Ca2+ accumulation. Heparin up to 100 micrograms/ml had no effect on the GTP-activated Ca2+ translocation process previously characterized in this cell line. Half-maximal inhibition of Ca2+ release activated by 10 microM InsP3 occurred with heparin at approximately 0.6 and 0.2 microgram/ml in permeabilized cells and isolated microsomes, respectively. Using microsomes, InsP3 dose-response curves in the presence and absence of 0.2 microgram/ml heparin (approximately 40 nM) revealed a 10-fold increase in apparent Km for InsP3 (0.31 microM in the absence of heparin) with no change in Vmax, indicating a competitive action of heparin. The results revealed a very high apparent affinity of heparin for the InsP3 active site, with a calculated Ki value of 2.7 nM. Heparin was shown to rapidly (within 20 s) reverse prior full activation of InsP3-mediated Ca2+ release returning the Ca2+ equilibrium back to that observed without InsP3. This reversal occurs even after prolonged (6 min) InsP3 activation. These results indicate a specific, high affinity, and competitive antagonism of the InsP3 active site by heparin. The rapidly induced reversal of InsP3-activated Ca2+ release by heparin strongly suggests that InsP3 directly activates a channel which remains open only while InsP3 is associated and closes immediately upon InsP3 dissociation.
Decreased Phorbol Myristate Acetate-Induced Release of Tumor Necrosis Factor- and Interleukin-l from Peripheral Blood Monocytes of Patients Chronically Infected with Hepatitis C Virus (1996)

Hepatitis C virus (HCV) has been detected in peripheral blood mononuclear cells (PBMC) from persons chronically infected with HCV. Reports describe altered monocytic function during HCV infection; however, the immunologic consequences of HCV tropism for human macrophages are not well defined. Thus, the possibility that HCV infection of monocytes may alter patterns of cytokine release was investigated. The in vitro secretion of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta in response to phorbol myristate acetate-stimulated monocytes and PBMC of subjects chronically infected or not infected with HCV was compared. TNF-alpha and IL-1 beta release were suppressed in cells from infected subjects. Although virus-induced immunosuppression is not a major clinical syndrome of HCV infection, the findings support a hypothesis that HCV can induce selective defects in antigen-presenting cells that may enhance the ability of HCV to persist despite the presence of cytotoxic killer cells and antibody directed against HCV.
Modified Lapidus Procedure for the Treatment of Hypermobile Hallux Valgus (2000)

The intermediate outcome of patients who underwent a modified Lapidus procedure for the treatment of hallux valgus secondary to a hypermobile first ray was evaluated with an outcome tool to determine if their pain and functional status were improved. We evaluated 31 feet in 26 patients who underwent a modified Lapidus procedure. All working patients (100%) returned to full-time work. Six patients were retired and one was unemployed prior to surgery. There was an average of eight months until sports or unlimited activities were performed, and an average 16 weeks until conventional shoes could be worn. All patients but one (96%) were satisfied with the surgery and knowing their results would have the surgery again. Postoperative pain relief satisfaction was totally satisfied in 19 patients, satisfied with reservations in six patients, and not satisfied in one patient. Postoperative appearance satisfaction was totally satisfied in 21 patients and satisfied with reservations in five patients. Postoperative joint motion was no noticeable stiffness in 22 patients, noticeable stiffness but not bothersome in three patients, and stiffness that impairs activity in one patient (two feet). In the radiographic measurements, there was an average improvement of 10 degrees in the hallux valgus angle, 10 degrees in the intermetatarsal angle, two degrees in the lateral metatarsal-floor angle and two grades in the sesamoid position. Complications experienced were five recurrent deformities, two metatarsalgias, and one deep vein thrombosis. One of the five recurrences became symptomatic and required a revision.
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system (2013)

The compound BAY 11-7082 inhibits IκBα [inhibitor of NF-κB (nuclear factor κB)α] phosphorylation in cells and has been used to implicate the canonical IKKs (IκB kinases) and NF-κB in >350 publications. In the present study we report that BAY 11-7082 does not inhibit the IKKs, but suppresses their activation in LPS (lipopolysaccharide)-stimulated RAW macrophages and IL (interleukin)-1-stimulated IL-1R (IL-1 receptor) HEK (human embryonic kidney)-293 cells. BAY 11-7082 exerts these effects by inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex), thereby preventing the formation of Lys63-linked and linear polyubiquitin chains. BAY 11-7082 prevents ubiquitin conjugation to Ubc13 and UbcH7 by forming a covalent adduct with their reactive cysteine residues via Michael addition at the C3 atom of BAY 11-7082, followed by the release of 4-methylbenzene-sulfinic acid. BAY 11-7082 stimulated Lys48-linked polyubiquitin chain formation in cells and protected HIF1α (hypoxia-inducible factor 1α) from proteasomal degradation, suggesting that it inhibits the proteasome. The results of the present study indicate that the anti-inflammatory effects of BAY 11-7082, its ability to induce B-cell lymphoma and leukaemic T-cell death and to prevent the recruitment of proteins to sites of DNA damage are exerted via inhibition of components of the ubiquitin system and not by inhibiting NF-κB.
Comparison of direct and external modulation for CATV lightwave transmission at 1.5 μm wavelength (1992)

The use of a high-power 1.5μm DFB laser and a linearised Ti: LiNbO3 Mach-Zehnder modulator as a transmitter in a CATV lightwave system is reported. The performance is compared with directly-modulated 1.5μm-wavelength DFB lasers in 60 channel transmission over 16km of conventional singlemode fibre. The transmission of 52 high-frequency channels is demonstrated (450–750 MHz) in anticipation of future CATV upgrades.
Industry Year 1986 (1986)

It is perhaps not widely known that the Royal Society of Arts, founded in the 18th century, includes in its title the words 'encouragement of manufacture and commerce'. It was therefore appropriate that the society should have proposed Industry Year 1986.
β-Diketones. II. Ultraviolet and Infrared Spectra of Some 2-Aroylcyclohexanones1,2 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTβ-Diketones. II. Ultraviolet and Infrared Spectra of Some 2-Aroylcyclohexanones1,2R. D. Campbell and H. M. GilowCite this: J. Am. Chem. Soc. 1960, 82, 20, 5426–5431Publication Date (Print):October 1, 1960Publication History Published online1 May 2002Published inissue 1 October 1960https://pubs.acs.org/doi/10.1021/ja01505a032https://doi.org/10.1021/ja01505a032research-articleACS PublicationsRequest reuse permissionsArticle Views148Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family (2000)

The sporadic form of PPH is associated with germline mutations of the gene encoding the receptor protein BMPR-II in at least 26% of cases. A molecular classification of PPH, based upon the presence or absence of BMPR2 mutations, has important implications for patient management and screening of relatives.
Induction of protective immunity against a Chlamydia trachomatis genital infection in three genetically distinct strains of mice (2003)

Summary To establish the feasibility of inducing a protective immune response against a chlamydial genital infection in animals with different genetic backgrounds, groups of C3H/HeN (H‐2 k ), BALB/c (H‐2 d ) and C57BL/6 (H‐2 b ) mice, were immunized intranasally with elementary bodies (EB) of the Chlamydia trachomatis mouse pneumonitis biovar. Following the intranasal immunization strong Chlamydia ‐specific humoral and cell‐mediated immune (CMI) responses were detected in the three strains of mice. Eight weeks following immunization the animals were challenged with C. trachomatis in the genital tract. Vaginal cultures showed that the three strains of mice immunized with EB were significantly protected in comparison to the sham immunized animals. To determine the ability of this immunization protocol to protect against infertility six weeks after the genital challenge the animals were mated. Mice of the three strains immunized with EB showed significant protection as demonstrated by the number of animals that were fertile, and the number of embryos present in their uterine horns, in comparison to the sham immunized mice.
Monoclonal Anti-Idiotypic Antibodies as Surrogates for Hepatitis B Surface Antigen (1986)

(1986). Monoclonal Anti-Idiotypic Antibodies as Surrogates for Hepatitis B Surface Antigen. International Reviews of Immunology: Vol. 1, No. 1, pp. 27-39.
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML (2008)

SDF-1alpha/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow-derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML). Here we demonstrate that the CXCR4 inhibitor AMD3465 antagonized stromal-derived factor 1alpha (SDF-1alpha)-induced and stroma-induced chemotaxis and inhibited SDF-1alpha-induced activation of prosurvival signaling pathways in leukemic cells. Further, CXCR4 inhibition partially abrogated the protective effects of stromal cells on chemotherapy-induced apoptosis in AML cells. Fetal liver tyrosine kinase-3 (FLT3) gene mutations activate CXCR4 signaling, and coculture with stromal cells significantly diminished antileukemia effects of FLT3 inhibitors in cells with mutated FLT3. Notably, CXCR4 inhibition increased the sensitivity of FLT3-mutated leukemic cells to the apoptogenic effects of the FLT3 inhibitor sorafenib. In vivo studies demonstrated that AMD3465, alone or in combination with granulocyte colony-stimulating factor, induced mobilization of AML cells and progenitor cells into circulation and enhanced antileukemic effects of chemotherapy and sorafenib, resulting in markedly reduced leukemia burden and prolonged survival of the animals. These findings indicate that SDF-1alpha/CXCR4 interactions contribute to the resistance of leukemic cells to signal transduction inhibitor- and chemotherapy-induced apoptosis in systems mimicking the physiologic microenvironment. Disruption of these interactions with CXCR4 inhibitors represents a novel strategy of sensitizing leukemic cells by targeting their protective bone marrow microenvironment.
Seven ferritin kits compared with respect to the "hook" effect. (1984)

Journal Article Seven ferritin kits compared with respect to the "hook" effect. Get access G Anido G Anido Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 30, Issue 3, 1 March 1984, Page 500, https://doi.org/10.1093/clinchem/30.3.500 Published: 01 March 1984
Design, statistical analysis and sample size calculation of a phase IIb/III study of linagliptin versus voglibose and placebo (2009)

This is the first phase IIb/III study to examine the long-term safety and efficacy of linagliptin in diabetes patients in the Japanese population.
A novel polymerase chain reaction method for detection of human immunodeficiency virus in dried blood spots on filter paper (1992)

A method for detection of proviral human immunodeficiency virus DNA in dried blood spots on filter paper by direct polymerase chain reaction (PCR) has been developed. To develop the method, a standard system was used which was prepared from cells each containing a single integrated provirus and titrated with normal donor blood. This rapid procedure provides virtually quantitative yields of nuclear DNA and exploits most of the standard methodology described for blood specimens. A nested PCR using SK38-SK39 gag as the internal primer pair was also designed; this PCR detected a single copy of provirus per filter at near theoretical frequency with SK19 probe. The utility of the procedure was demonstrated with clinical specimens. Blood spot filters from human immunodeficiency virus-infected and uninfected individuals were readily and unequivocally discriminated. The method is designed for ultimate use with large (1.5-ml) sample preparation tubes that are compatible as PCR tubes with thermal cyclers. This will permit convenient, direct single-tube PCR of dried blood specimens on filters. It should be adaptable to analysis of dried blood spots for a variety of infectious or genetic diseases.
The Effect of Divided Attention on Encoding and Retrieval in Episodic Memory Revealed by Positron Emission Tomography (2000)

The effects of divided attention (DA) on episodic memory encoding and retrieval were investigated in 12 normal young subjects by positron emission tomography (PET). Cerebral blood flow was measured while subjects were concurrently performing a memory task (encoding and retrieval of visually presented word pairs) and an auditory tone-discrimination task. The PET data were analyzed using multivariate Partial Least Squares (PLS), and the results revealed three sets of neural correlates related to specific task contrasts. Brain activity, relatively greater under conditions of full attention (FA) than DA, was identified in the occipital-temporal, medial, and ventral-frontal areas, whereas areas showing relatively more activity under DA than FA were found in the cerebellum, temporo-parietal, left anterior-cingulate gyrus, and bilateral dorsolateral-prefrontal areas. Regions more active during encoding than during retrieval were located in the hippocampus, temporal and the prefrontal cortex of the left hemisphere, and regions more active during retrieval than during encoding included areas in the medial and right-prefrontal cortex, basal ganglia, thalamus, and cuneus. DA at encoding was associated with specific decreases in rCBF in the left-prefrontal areas, whereas DA at retrieval was associated with decreased rCBF in a relatively small region in the right-prefrontal cortex. These different patterns of activity are related to the behavioral results, which showed a substantial decrease in memory performance when the DA task was performed at encoding, but no change in memory levels when the DA task was performed at retrieval.
Coagulation factor levels in plasma frozen within 24 hours of phlebotomy over 5 days of storage at 1 to 6°C (2008)

The activity of all factors assayed, except for PS, were within their normal range during the 5-day storage period. These results show comparable factor assay levels in TP prepared from fresh-frozen plasma and FP24.
Factors Associated With Persistent Subfoveal Fluid and Complete Macular Hole Closure in the PIONEER Study (2014)

Persistent subfoveal fluid following MH surgery is a common finding that appears to delay visual recovery but not effect final visual outcome. The incidence of persistent subfoveal fluid appears to be related to intraoperative alterations after ILM peeling in the outer retinal architecture (e.g., increased EZ-RPE height and SRHR width). This finding suggests a novel mechanism for facilitating MH closure through ILM peeling (e.g., altering photoreceptor/RPE adherence and increasing retinal mobility that allows for complete hole closure).
25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3 (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3J. W. Blunt, H. F. DeLuca, and H. K. SchnoesCite this: Biochemistry 1968, 7, 10, 3317–3322Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://pubs.acs.org/doi/10.1021/bi00850a001https://doi.org/10.1021/bi00850a001research-articleACS PublicationsRequest reuse permissionsArticle Views550Altmetric-Citations423LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts