gebhart/patrepeval huggingface dataset:
Control of nonlinear mechatronics systems by using universal learning networks (2003)

Nonlinear elements such as friction, dead zone, backlash are mixed in most mechatronics systems, and these are factors that make control accuracy of systems decrease and cause an oscillation. In this paper, a design method for nonlinear mechatronics control systems is proposed, in which both of the control object and its controller are represented by using a universal learning network, and the network parameters are trained using a random search algorithm called RasID. In this approach, knowledge and experience about models and controllers are easily incorporated into the network including the nonlinear elements and their compensation elements expressed by non-differentiable functions. Some simulations of a nonlinear crane control system with dead-zone characteristic were carried out. The effectiveness of the proposed design method is illustrated via simulations.
Diastereomers of 5'-O-adenosyl 3'-O-uridyl phosphorothioate: chemical synthesis and enzymic properties (1979)

A procedure is described for the synthesis of the title compounds via phosphotriester intermediates. The 2-cyanoethyl group is used to protect the P-SH function during the course of the synthesis. Resolution of the phosphorus diastereomers is accomplished at the phosphotriester stage. Removal of the 2-cyanoethyl group without racemization, followed by removal of the other protective groups, affords the optically pure diastereomers of 5'-O-adenosyl 3'-O-uridyl phosphorothioate. Their designation as Rp and Sp follows from the stereospecificity in the hydrolysis catalyzed by RNase A. These diastereomers are useful for the investigation of the stereospecificity as well as of the stereochemical course of action of nucleases. Snake venom exonuclease hydrolyses only the Rp diastereomer, whereas both diastereomers are substrates for RNases A and T2. The results with the latter indicate that RNase T2 also operates by an in-line mechanism.
KINETICS OF CELL RENEWAL, CELL MIGRATION AND CELL LOSS IN THE HAIRLESS MOUSE DORSAL EPIDERMIS (1968)

ABSTRACT Forty hairless mice were given injections of tritiated thymidine every 4th hour during 10 days. At 24 hr intervals groups of four mice were killed. The numbers of labelled basal and differentiating cells were determined by autoradiography with a stripping film technique. To determine the background activity skin sections from uninjected control mice were subjected to the same stripping film procedure. Another group of hairless mice was given one single pulse labelling with tritiated thymidine. The number of labelled mitoses was scored for 12 hr after the injection. At 10, 12 and 15 hr after the injection, the numbers of labelled basal and differentiating cells were also determined. A mathematical model of cell population kinetics in the epidermis has been suggested. The results of different simulations on this model were compared with the observed results. The curve of mean grain counts under continuous labelling increased from day to day with two well‐defined plateaux. The percentage of all labelled cells increased rapidly up to the 3rd day, and thereafter the curves gradually flattened off. When basal cells and differentiated cells were considered separately the labelling index of the basal cells increased rapidly for the first 3 days and then flattened off at the 100% level on the 5th day. The labelling index of the differentiating cells was low during the first 3–4 days. Then a steep increase in the percentage of labelled differentiating cells was seen, but the curve flattened off again close to the 100 % level after the 7th day. The labelled mitosis curve had its maximum 5 hr after the thymidine injection. The curve fell again to almost zero at 12 hr. Ten, 12 and 15 hr after the injection, 6, 7 and 7% respectively of the labelled cells were found in the spinous layer. It was concluded that three grains over each nucleus could be used as lower limit for considering a cell as labelled. On this basis, tritiated thymidine injections every 4th hour can be considered as continuous labelling.
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE (1999)

Parkinson's disease (PD) is an age-related neurodegenerative disorder that affects approximately 1 million persons in the United States. It is characterized by resting tremor, rigidity, bradykinesia or slowness, gait disturbance, and postural instability. Pathological features include degeneration of dopaminergic neurons in the substantia nigra pars compacta coupled with intracytoplasmic inclusions known as Lewy bodies. Neurodegeneration and Lewy bodies can also be found in the locus ceruleus, nucleus basalis, hypothalamus, cerebral cortex, cranial nerve motor nuclei, and central and peripheral components of the autonomic nervous system. Current treatment consists of a dopamine replacement strategy using primarily the dopamine precursor levodopa. While levodopa provides benefit to virtually all PD patients, after 5-10 years of treatment the majority of patients develop adverse events in the form of dyskinesia (involuntary movements) and fluctuations in motor response. Further, disease progression is associated with the development of dementia, autonomic dysfunction, and postural instability, which do not respond to levodopa therapy. Accordingly, research efforts have been directed toward understanding the etiology and pathogenesis of PD in the hope of developing a more effective therapy that will slow or halt the natural progression of PD. This paper reviews recent advances.
Report of the ad hoc committee for the re-evaluation of the species definition in bacteriology. (2002)

An ad hoc committee for the re-evaluation of the species definition in bacteriology met in Gent, Belgium, in February 2002. The committee made various recommendations regarding the species definition in the light of developments in methodologies available to systematists.
Long‐term durability of the interface in FRP composites after exposure to simulated physiologic saline environments (1994)

Fiber/matrix interfacial bond strength significantly influences the mechanical behavior of fiber-reinforced polymer (FRP) composites. Interfacial bond strength durability is therefore particularly important in the development of FRP composites for implant applications where diffused moisture may potentially weaken the material over time. In this study, the long-term durability of interfacial bonding in carbon fiber/380 grade polyetheretherketone (C/PEEK) and carbon fiber/polysulfone (C/PSF) composites was investigated after exposure to hygrothermal environments. A single fiber pull-out test was used to quantitatively determine the ultimate bond strength (UBS) of the samples following exposure. Samples were tested at three temperatures (37, 65, and 95 degrees C) for six time periods (0-5000 h) and in two environments (dry and physiologic saline-immersed). A mathematical model based on nth order chemical reaction kinetics was applied to describe the long-term durability of the interface. The results of this study indicate that interfacial bond strengths in C/PSF and C/PEEK (380 grade) composites are significantly decreased by exposure to physiologic saline and are functions of both time and temperature. For each material, the kinetics of degradation analysis predicts further bond strength losses following initial saturation, which then stabilizes at temperature-dependent equilibrium bond strength levels.
Convolutional neural networks on surfaces via seamless toric covers (2017)

The recent success of convolutional neural networks (CNNs) for image processing tasks is inspiring research efforts attempting to achieve similar success for geometric tasks. One of the main challenges in applying CNNs to surfaces is defining a natural convolution operator on surfaces. In this paper we present a method for applying deep learning to sphere-type shapes using a global seamless parameterization to a planar flat-torus, for which the convolution operator is well defined. As a result, the standard deep learning framework can be readily applied for learning semantic, high-level properties of the shape. An indication of our success in bridging the gap between images and surfaces is the fact that our algorithm succeeds in learning semantic information from an input of raw low-dimensional feature vectors. We demonstrate the usefulness of our approach by presenting two applications: human body segmentation, and automatic landmark detection on anatomical surfaces. We show that our algorithm compares favorably with competing geometric deep-learning algorithms for segmentation tasks, and is able to produce meaningful correspondences on anatomical surfaces where hand-crafted features are bound to fail.
Collecting user access patterns for building user profiles and collaborative filtering (1998)

The paper proposes a new learning mechanism to extract user preferences transparently for a World Wide Web recommender system. The general idea is that we use the entropy of the page being accessed to determine its interestingness based on its occurrence probability following a sequence of pages accessed by the user. The probability distribution of the pages is obtained by collecting the access patterns of users navigating on the Web. A finite context-model is used to represent the usage information.
Precise control of broadband frequency chirps using optoelectronic feedback (2009)

We demonstrate the generation of wideband frequency sweeps using a semiconductor laser in an optoelectronic feedback loop. The rate and shape of the optical frequency sweep is locked to and determined by the frequency of a reference electronic signal, leading to an agile, high coherence swept-frequency source for laser ranging and 3-D imaging applications. Using a reference signal of constant frequency, a transform-limited linear sweep of 100 GHz in 1 ms is achieved, and real-time ranging with a spatial resolution of 1.5 mm is demonstrated. Further, arbitrary frequency sweeps can be achieved by tuning the frequency of the input electronic signal. Broadband quadratic and exponential optical frequency sweeps are demonstrated using this technique.
Large-area 97-μm pitch indirect-detection active-matrix flat-panel imager (AMFPI) (1998)

The development of the highest resolution, large-area, active- matrix, flat-panel, imager (AMFPI) thus far reported is described. This imager is based on a 97 micrometer pixel pitch array with each pixel comprising a single a-Si:H TFT coupled to a discrete a-Si:H n-i-p photodiode. While the initial configuration chosen for fabrication is a 2048 X 2048 pixel array, a larger monolithic array format of 3072 X 4096 pixels is also permitted by the design. When coupled to an overlying scintillator such as a phosphor screen or CsI:Tl, the array allows indirect detection of incident radiation. The array is operated in conjunction with a recently completed electronic acquisition system featuring asynchronous operation, a large addressing range, fast analog signal extraction and digitization, and 16-bit digitization. This imager, whose empirical characterization will be reported in a subsequent paper, was developed as an engineering prototype to allow investigation of the performance limits of the most aggressive array designs permitted by present active-matrix technology. The development of this new imager builds upon knowledge acquired from the iterative design, fabrication, and quantitative evaluation of earlier engineering prototypes based on a series of 127 micrometer pitch arrays. This paper summarizes the general program of research leading to this new device and puts this in the context of world-wide developments in indirect and direct detection AMFPI technology. Some limitations of present AMFPI technology are described, and possible solutions are discussed. Specifically, the incorporation of multiplexers based on poly-crystalline silicon circuitry into the array design, to facilitate very high resolution imagers, are proposed. In addition, strategies to significantly improve AMFPI performance at very low exposures, such as those commonly encountered in fluoroscopy, involving the reduction of additive noise (such as through lower preamplifier noise) and the enhancement of system gain (such as through the use of lead iodide) are discussed and initial calculations illustrating potential levels of performance are presented.
Extending Q-Learning to General Adaptive Multi-Agent Systems (2003)

Recent multi-agent extensions of Q-Learning require knowledge of other agents&amp;apos; payoffs and Q-functions, and assume game-theoretic play at all times by all other agents. This paper proposes a fundamentally different approach, dubbed &amp;quot;Hyper-Q&amp;quot; Learning, in which values of mixed strategies rather than base actions are learned, and in which other agents&amp;apos; strategies are estimated from observed actions via Bayesian inference. Hyper-Q
Guest Editorial: Assessing Risks and Benefits of Genistein and Soy (2006)

His research focuses on cholesterol and and bile acid metabolism in liver disease and on nutrition related to estrogen and phytoestrogen
Identifying CpG sites with different differential methylation frequencies in colorectal cancer tissues based on individualized differential methylation analysis (2017)

A big challenge to clinical diagnosis and therapy of colorectal cancer (CRC) is its extreme heterogeneity, and thus it would be of special importance if we could find common biomarkers besides subtype-specific biomarkers for CRC. Here, with DNA methylation data produced by different laboratories, we firstly revealed that the relative methylation-level orderings (RMOs) of CpG sites within colorectal normal tissues are highly stable but widely disrupted in the CRC tissues. This finding provides the basis for using the RankComp algorithm to identify differentially methylated (DM) CpG sites in every individual CRC sample through comparing the RMOs within the individual sample with the stable RMOs predetermined in normal tissues. For 75 CRC samples, RankComp detected averagely 4,062 DM CpG sites per sample and reached an average precision of 91.34% in terms that the hypermethylation or hypomethylation states of the DM CpG sites detected for each cancer sample were consistent with the observed differences between this cancer sample and its paired adjacent normal sample. Finally, we applied RankComp to identify DM CpG sites for each of the 268 CRC samples from The Cancer Genome Atlas and found 26 and 143 genes whose promoter regions included CpG sites that were hypermethylated and hypomethylated, respectively, in more than 95% of the 268 CRC samples. Individualized pathway analysis identified six pathways that were significantly enriched with DM genes in more than 90% of the CRC tissues. These universal DNA methylation biomarkers could be important diagnostic makers and therapy targets for CRC.
Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers (2008)

Graft-versus-tumor effects can be achieved after allogeneic bone marrow transplantation in patients with malignancies of the kidney or hematopoietic system but are often accompanied by severe graft-versus-host-disease (GVHD). We sought to maximize graft-versus-tumor while minimizing GVHD using tumor-specific allogeneic effector T cells rather than open-repertoire T cells. We transferred allogeneic CD8(+) pmel-1 or CD4(+) TRP-1 T cells specific for the melanoma-associated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into B16-melanoma-bearing mice. Mice receiving a preparative regimen of nonmyeloablating (5 Gy) total body irradiation experienced the rapid rejection of tumor-specific allogeneic lymphocytes with no impact on tumor growth. However, when mice were given more intense total body irradiation conditioning regimens combined with autologous bone marrow transplantation, adoptively transferred allogeneic tumor-specific T lymphocytes persisted at detectable levels for several weeks and mediated significant regression of large, vascularized tumors. We found that the risk of GVHD was low when tumor-specific T cells were transferred and significant toxicity was observed only when substantial numbers of open repertoire allogeneic naive T cells were mixed with the tumor-specific lymphocytes. Taken together, these data indicate that the use of tumor-specific allogeneic CD8(+) T cells or CD4(+) can result in significant antitumor effects in the absence of measurable GVHD.
Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability (2013)

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.
<title>Watermark capacity measure incorporating a model of the human visual system</title> (2001)

The problem of evaluating the maximum number of information bits that can be hidden within an image is considered; usually it is addressed by looking at the watermarking process as a communication task, in which the signal, i.e. the watermark, is transmitted over the channel, the host data acts the part of. Thus the maximum number of information bits is the capacity of the watermark-channel. By relying on experimental results in which the dependence of the watermark capacity upon the watermark strength G is evidenced, the knowledge of the maximum allowed watermark level, under the constraint of watermark invisibility, is required. G is often interactively adjusted to the image at hand, because no simple algorithm exists that permits to fit the watermark level according to the characteristics of the host image. Hence, a novel algorithm to model the Human Visual System has been developed which considers frequency sensitivity, local luminance and contrast masking effects. The proposed method exploits a block based DCT decomposition of the image, that permits to trade off between spatial and frequency localisation of the image features and disturbs. Through this model, the maximum allowable watermark strength is determined in a completely automatic mode and then the value of watermark capacity is computed.
Inkjet-printed gold nanoparticle electrochemical arrays on plastic. Application to immunodetection of a cancer biomarker protein (2011)

Electrochemical detection combined with nanostructured sensor surfaces offers potentially low-cost, high-throughput solutions for detection of clinically significant proteins. Inkjet printing offers an inexpensive non-contact fabrication method for microelectronics that is easily adapted for incorporating into protein immunosensor devices. Herein we report the first direct fabrication of inkjet-printed gold nanoparticle arrays, and apply them to electrochemical detection of the cancer biomarker interleukin-6 (IL-6) in serum. The gold nanoparticle ink was printed on a flexible, heat resistant polyimide Kapton substrate and subsequently sintered to create eight-electrode arrays costing <0.2 euro per array. The inkjet-printed working electrodes had reproducible surface areas with RSD <3%. Capture antibodies for IL-6 were linked onto the eight-electrode array, and used in sandwich immunoassays. A biotinylated secondary antibody with 16-18 horseradish peroxidase labels was used, and detection was achieved by hydroquinone-mediated amperometry. The arrays provided a clinically relevant detection limit of 20 pg mL(-1) in calf serum, sensitivity of 11.4 nA pg(-1) cm(-2), and a linear dynamic range of 20-400 pg mL(-1).
Free Interleukin (IL)-18 Levels, and the Impact of IL18 and IL18BP Genetic Variation, in CHD Patients and Healthy Men (2007)

IL-18 levels, which are determined in part by variation in IL18, play a role in CHD development and postsurgery outcome.
The epidemiology of anxiety disorders: a review (2003)

Epidemiological studies show that anxiety disorders are highly prevalent and an important cause of functional impairment; they constitute the most frequent menial disorders in the community. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsive disorder (OCD) are less frequent (2% lifetime prevalence), and there are discordant results for social phobia (SP) (2%-16%) and generalized anxiety disorder (GAD) (3%-30%). These studies underline the importance of an accurate definition of disorders using unambiguous diagnostic and assessment criteria. The boundaries between anxiety disorders are often ill defined and cases may vary widely according to the definition applied. Simple phobia, agoraphobia, and GAD are more common in vmrnen, while there is no gender différence for SP, PD, and OCD, Anxiety disorders are more common in separated, divorced, and widowed subjects; their prevalence is highest in subjects aged 25 to 44 years and lowest in subjects aged >65 years. The age of onset of the different types of anxiety disorders varies widely: phobic disorders begin early in life, whereas PD occurs in young adulthood. Clinical - rather than epidemiological - studies have examined risk factors such as life events, childhood experiences, and familial factors. Anxiety disorders have a chronic and persistent course, and are frequently comorbid with other anxiety disorders, depressive disorders, and substance abuse. Anxiety disorders most frequently precede depressive disorders or substance abuse, Comorbid diagnoses may influence risk factors like functional impairment and quality of life. It remains unclear whether certain anxiety disorders (eg, PD) are risk factors for suicide. The comorbidity of anxiety disorders has important implications for assessment and treatment and the risk factors should be explored. The etiology, natural history, and outcome of these disorders need to be further addressed in epidemiological studies.
A role for proteinase-activated receptor–1 in inflammatory bowel diseases (2004)

Proteinase-activated receptor–1 (PAR1), a G protein–coupled receptor activated by thrombin, is highly expressed in different cell types of the gastrointestinal tract. The activity of thrombin and of other proteinases is significantly increased in the colon of inflammatory bowel disease (IBD) patients. Since PAR1 activation in tissues other than the gut provoked inflammation, we hypothesized that PAR1 activation in the colon is involved in the pathogenesis of IBD. Here, we demonstrate that PAR1 is overexpressed in the colon of IBD patients. In mice, intracolonic administration of PAR1 agonists led to an inflammatory reaction characterized by edema and granulocyte infiltration. This PAR1 activation–induced inflammation was dependent on B and T lymphocytes. Moreover, PAR1 activation exacerbated and prolonged inflammation in a mouse model of IBD induced by the intracolonic administration of trinitrobenzene sulfonic acid (TNBS), while PAR1 antagonism significantly decreased the mortality and severity of colonic inflammation induced by TNBS and dextran sodium sulfate. In these 2 models, colitis development was strongly attenuated by PAR1 deficiency. Taken together, these results imply an important role for PAR1 in the pathogenesis of experimental colitis, supporting the notion that PAR1 inhibition may be beneficial in the context of IBD and possibly in other chronic intestinal inflammatory disorders.