gebhart/patrepeval huggingface dataset:
State of Art on ORC Applications for Waste Heat Recovery and Micro-cogeneration for Installations up to 100kWe (2015)

The growing cost for energy production and distribution as well as problems related to environmental pollution have induced an increasing interest in the research of alternative solutions and in particular innovative technologies capable of compromising energy production cost, optimization and guaranteeing environmental sustainability. One of the technologies of increasing interest in recent years is the Organic Rankine Cycle (ORC). These systems are generally suitable for the recovery of low grade heat at low pressure this is a major advantage of the system in terms of safety and management. Furthermore, they enhance simple operation, low maintenance, and the use of a working fluid that is environmentally friendly. This paper presents a comprehensive and current literature overview of micro generation systems up to 100kWe. A working fluid screening criteria has been discussed taking into account the environmental impact as well as the thermo-physical properties of various potential working fluids. From the analyses it emerges that the fluid most used in installed ORC systems is the R245fa also confirmed by means of a computational code developed for micro-systems of the size range. Components and expander selection has also been examined, the study reveals that the most suitable expander for the applications of these plant size ranges are the scroll for small installations and the vane or screw expanders for larger installations. Finally a detailed list of characteristics of both industrial and experimental prototype application is presented with references to their manufacturers.
Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. (1984)

Monoclonal antibodies (MAbs) of predefined specificity have been generated by utilizing a synthetic peptide reflecting amino acid positions 10-17 of the Hu-rasT24 gene product as immunogen. These MAbs, designated RAP-1 through RAP-5 (RA, ras; P, peptide), have been shown to react with the ras gene product p21. Since the Hu-ras reactive determinants (positions 10-17) have been predicted to be within the tertiary structure of the p21 molecule, it was not unexpected that denaturation of cell extracts or tissue sections with Formalin or glutaraldehyde enhanced binding of the RAP MAbs. When paraffin-embedded Formalin-fixed tissue sections and the avidin-biotin complex immunoperoxidase method were used, the RAP MAbs clearly defined enhanced ras p21 expression in the majority of human colon and mammary carcinomas. The majority of all abnormal ducts and lobules from fibroadenoma and fibrocystic disease patients were negative, as were all normal mammary and colonic epithelia examined. The findings reported here form the basis for quantitative radioimmunoassays for a ras translational product and provide a means to evaluate ras p21 expression within individual cells of normal tissues and benign, "premalignant," and malignant lesions.
Magnetic properties of V-doped ZnO thin films (2005)

Ferromagnetic V-doped ZnO films were fabricated by the conventional pulsed-laser deposition technique on R-cut sapphire substrates from a ceramic target that was made by sol-gel method. All films are highly crystallized to be wurtzite. V-doped ZnO thin films grown at 600–650°C show room-temperature ferromagnetism along with a spin-glass-like behavior at low temperatures. It is found that V atoms were distributed very uniformly in the ZnO matrix. However, different growth conditions could result in different values of the saturation magnetic moment, and an increase of the substrate temperature above 650°C seems to favor a secondary phase, which is antiferromagnetic.
Estimating Dominance in Multi-Party Meetings Using Speaker Diarization (2010)

With the increase in cheap commercially available sensors, recording meetings is becoming an increasingly practical option. With this trend comes the need to summarize the recorded data in semantically meaningful ways. Here, we investigate the task of automatically measuring dominance in small group meetings when only a single audio source is available. Past research has found that speaking length as a single feature, provides a very good estimate of dominance. For these tasks we use speaker segmentations generated by our automated faster than real-time speaker diarization algorithm, where the number of speakers is not known beforehand. From user-annotated data, we analyze how the inherent variability of the annotations affects the performance of our dominance estimation method. We primarily focus on examining of how the performance of the speaker diarization and our dominance tasks vary under different experimental conditions and computationally efficient strategies, and how this would impact on a practical implementation of such a system. Despite the use of a state-of-the-art speaker diarization algorithm, speaker segments can be noisy. On conducting experiments on almost 5 hours of audio-visual meeting data, our results show that the dominance estimation is robust to increasing diarization noise.
OMNI: OpenFlow MaNagement Infrastructure (2011)

Managing computer networks is challenging because of the numerous monitoring variables and the difficulty to autonomously configure network parameters. This paper presents the OpenFlow MaNagement Infrastructure (OMNI), which helps the administrator to control and manage OpenFlow networks by providing remote management based on a web interface. OMNI provides flow monitoring and dynamic flow configuration through a service-oriented architecture. OMNI also offers an Application Programming Interface (API) for collecting data and configuring the OpenFlow network. We propose a multi-agent system based on OMNI API that reduces packet loss rates. We evaluate both the OMNI management applications and the multi-agent system performance using a testbed. Our results show that the multi-agent system detects and reacts to a packet-loss condition in less than three monitoring intervals.
Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C (1998)

In patients with chronic hepatitis C, initial therapy with interferon and ribavirin was more effective than treatment with interferon alone.
PHOTOINDUCED ELECTRON TRANSFER QUENCHING OF EXCITED Ru(II) POLYPYRIDYLS BOUND TO DNA: THE ROLE OF THE NUCLEIC ACID DOUBLE HELIX (1991)

In the presence of double helical polynucleotides (sodium poly(dA-dT).poly(dA-dT) or calf thymus DNA), the efficiency of oxidative or reductive electron transfer between photoexcited ruthenium(II) chelates Ru(tap)2(hat)2+ or Ru(phen)2+(3) (where tap = 1,4,5,8-tetraazaphenanthrene, hat = 1,4,5,8,9,12-hexaazatriphenylene, and phen = 1,10-phenanthroline) and appropriate cationic quenchers (ethidium, Ru(NH3)3+(6), methyl viologen, or M(phen)3+(3), where M = Co, Rh, Cr) increases 1-2 orders of magnitude compared to the efficiency of the same quenching in microhomogeneous aqueous medium (kq = 0.3-1.8 x 10(9) M-1 s-1). The enhancement is more pronounced when the binding constant of the quencher (10(3) less than Kb less than 10(6) M-1) is large. Similar trends are found when the biopolymers are replaced by sodium poly(styrenesulfonate) (PSS). The accelerated electron transfer process is proposed to be due mainly to the effect of accumulation of the reagents in the electrostatic field of the polymer; if corrections for this effect are introduced (e.g. ratioing [quencher]/[polynucleotide]), the reaction rate becomes essentially independent of the polymer concentration. Based upon a model for electron transfer reaction of the complexes within a small cylindrical interface around the DNA helix, calculations of the bimolecular electron transfer rate constants are computed to be 10(3) times smaller when the reactants are bound to the double-stranded polynucleotides and decreased mobility of the cationic species is apparent. The effect is less pronounced if a simpler polyelectrolyte (PSS) is employed. Emission lifetimes of the Ru(II) polypyridyls bound to the DNA (0.32-2 microseconds, double exponential decays) are discussed as well.
Nicotinic acid: the broad‐spectrum lipid drug. A 50th anniversary review (2005)

Nicotinic acid has, like the Roman God Janus, two faces. One is the vitamin. The other is the broad-spectrum lipid drug. The Canadian pathologist Rudolf Altschul discovered 50 years ago that nicotinic acid in gram doses lowered plasma levels of cholesterol. From the point of view of treatment of the dyslipidaemias that are risk factors for clinical atherosclerosis nicotinic acid is a miracle drug. It lowers the levels of all atherogenic lipoproteins--VLDL and LDL with subclasses as well as Lp(a)--and in addition it raises more than any other drug the levels of the protective HDL lipoproteins. Trials have shown that treatment with nicotinic acid reduces progression of atherosclerosis, and clinical events and mortality from coronary heart disease. The new combination treatment with statin-lowering LDL and nicotinic acid-raising HDL is reviewed. A basic effect of nicotinic acid is the inhibition of fat-mobilizing lipolysis in adipose tissue leading to a lowering of plasma free fatty acids, which has many metabolic implications which are reviewed. The very recent discovery of a nicotinic acid receptor and the finding that the drug stimulates the expression of the ABCA 1 membrane cholesterol transporter have paved the way for exciting and promising new 50 years in the history of nicotinic acid.
Architecture considerations for tracing incoherent rays (2010)

This paper proposes a massively parallel hardware architecture for efficient tracing of incoherent rays, e.g. for global illumination. The general approach is centered around hierarchical treelet subdivision of the acceleration structure and repeated queueing/postponing of rays to reduce cache pressure. We describe a heuristic algorithm for determining the treelet subdivision, and show that our architecture can reduce the total memory bandwidth requirements by up to 90% in difficult scenes. Furthermore the architecture allows submitting rays in an arbitrary order with practically no performance penalty. We also conclude that scheduling algorithms can have an important effect on results, and that using fixed-size queues is not an appealing design choice. Increased auxiliary traffic, including traversal stacks, is identified as the foremost remaining challenge of this architecture.
Transport of hemolysin across the outer membrane of Escherichia coli requires two functions (1983)

Among a large collection of hemolysis-negative mutants obtained by mutagenesis of the Hly plasmid pHly152 with Tn5, we have isolated two classes of mutants which are defective in the transport of hemolysin across the outer membrane. The two cistrons (hylBa and hlyBb) which are affected in these mutants are located adjacent to each other on the hly determinant but are transcribed from different promoters. Recombinant plasmids were constructed which carry the two functions as combined or separated cistrons. These were shown to complement the two types of transport mutants. Studies on the compartmentation of hemolysin in these two classes of mutants indicate that most hemolysin (greater than 70%) in hlyBa mutants is located in the periplasmic space, whereas in hlyBb mutants a larger portion of hemolysin is associated with the outer membrane fraction. The phenotypic appearance of colonies from hlyBb mutants is that of beta-hemolytic Escherichia coli strains, indicating that a substantial portion of hemolysin has already reached the outside of the outer membrane without being released into the medium. Release was achieved readily when hlyBb mutants were complemented with a recombinant plasmid carrying hlyBb.
Double-Scale Roughness and Superhydrophobicity on Metalized Toray Carbon Fiber Paper (2009)

A simple, inexpensive route for the fabrication of a superhydrophobic metal surface is described. Carbon-carbon composite paper (Toray TGP-H) is electroplated with copper. The copper layer is made hydrophobic by self-assembling a monolayer of dodecanethiol. The surface topography required to induce superhydrophobic behavior is achieved by varying the plating bath composition (Cl-, PEG, and SPS additives) and the time of deposition (effective thickness of the Cu layer). The surface morphology created by the original arrangement of the carbon fibers in the Toray paper (diameter 8 microm, spacing 30 microm) does not produce superhydrophobic behavior. This is true for both continuous and incomplete copper coatings. Truly superhydrophobic behavior (large contact angles, 160-165 degrees, and very small contact angle hysteresis, 2 to 3 degrees) is achieved when a continuous copper layer is deposited on the carbon fibers and also a second micrometer-range roughness is developed as a result of the formation of small copper crystallites (size approximately 1 microm).
Outsourcing the decryption of ABE ciphertexts (2011)

Attribute-based encryption (ABE) is a new vision for public key encryption that allows users to encrypt and decrypt messages based on user attributes. For example, a user can create a ciphertext that can be decrypted only by other users with attributes satisfying (“Faculty ” OR (“PhD Student ” AND “Quals Completed”)). Given its expressiveness, ABE is currently being considered for many cloud storage and computing applications. However, one of the main efficiency drawbacks of ABE is that the size of the ciphertext and the time required to decrypt it grows with the complexity of the access formula. In this work, we propose a new paradigm for ABE that largely eliminates this overhead for users. Suppose that ABE ciphertexts are stored in the cloud. We show how a user can provide the cloud with a single transformation key that allows the cloud to translate any ABE ciphertext satisfied by that user’s attributes into a (constant-size) El Gamal-style ciphertext, without the cloud being able to read any part of the user’s messages. To precisely define and demonstrate the advantages of this approach, we provide new security definitions for both CPA and replayable CCA security with outsourcing, several new constructions, an implementation of our algorithms and detailed performance measurements. In a typical configuration, the user saves significantly on both bandwidth and decryption time, without increasing the number of transmissions.
Phase-shifted PWM control-a new integrated controller eases the design of efficient high-frequency bridge power switching (2002)

An integrated controller which is optimised for zero-voltage resonant switching of a square-wave bridge power topology is introduced. By modulating the power with phase control high efficiency can be achieved at high frequencies with the added benefit of constant frequency operation. Adaptable to both voltage and current mode control, this IC provides both regulating intelligence and fault protection.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Identifying Collocations for Recognizing Opinions (2001)

Subjectivity in natural language refers to aspects of language used to express opinions and evaluations (Banfield, 1982; Wiebe, 1994). There are numerous applications for which knowledge of subjectivity is relevant, including genre detection, information extraction, and information retrieval. This paper shows promising results for a straightforward method of identifying collocational clues of subjectivity, as well as evidence of the usefulness of these clues for recognizing opinionated documents. 1
MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability (2013)

Adaptor proteins are involved in the assembly of various intracellular complexes and the regulation of cellular functions. Membrane-associated guanylate kinase inverted 2 (MAGI2), also known as synaptic scaffolding molecule (S-SCAM), plays a critical role in signal transduction by assembling and anchoring its ligands. However, the role of MAGI2 in mediating apoptosis remains largely unknown. In the present study, BEL-7404 human hepatocellular carcinoma cells were transfected with a plasmid containing myc-MAGI2 or an empty plasmid and cell viability was then determined using the Cell Counting kit-8. Apoptosis was also detected using an Annexin V apoptosis assay. The cells were then treated with various doses of staurosporine (STS) for different periods of time. The overexpression of myc-MAGI2 was found to sensitize the BEL-7404 cells to apoptosis in response to STS in a time- and dose-dependent manner. Our results demonstrated that MAGI2 enhanced STS-induced apoptosis by increasing the protein expression of cytoplasmic phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and decreasing its protein degradation. The apoptotic sensitivity of the cells caused by the overexpression of myc-MAGI2 was reversed by the silencing of PTEN expression by PTEN siRNA, thus revealing a momentous role of PTEN in the enhancement of the sensitivity of cancer cells to STS-induced apoptosis by MAGI2. Finally, we observed that the MAGI-PTEN complex triggered by MAGI2 overexpression reduced the phosphorylation levels of AKT. These results suggest that MAGI2 overexpression enhances the sensitivity of cancer cells harboring ectopic PTEN to STS-induced apoptosis.
Expression of Cell Adhesion Molecules in Dilated Cardiomyopathy (1999)

Inflammatory endothelial activation is present in 67% of DCM patients. Because CAM expression correlates with the immunohistological diagnosis of InfCM and counterreceptor-bearing intramyocardial infiltrates, evaluation of endothelial CAMs might be of diagnostic significance in InfCM.
Dramatic Pituitary Hyperplasia in Transgenic Mice Expressing a Human Growth Hormone-Releasing Factor Gene (1988)

A transgenic animal model system was used to analyze the mitogenic effects of GRF on its target cell, the pituitary somatotroph. We have previously established a strain of mice that express a mouse metallothionein-I/human GRF (hGRF) fusion gene, and that grow to be abnormally large due to GH hypersecretion. We show here that chronic GRF production in these mice leads to the development of enormous pituitary glands. The increase in pituitary size appears to be largely the result of a selective proliferation (hyperplasia) of somatotrophs, the GH-producing cells. This observation provides direct evidence that a neuropeptide may act as a specific trophic factor for its target cell. In addition to this effect on pituitary development, we find that the pituitary is a major site of expression of mouse metallothionein-I/hGRF mRNA, and of hGRF peptide. This tissue specificity was unexpected in that neither component of the fusion gene is highly expressed in the normal pituitary. It suggests that pituitary somatotrophs might produce and respond to GRF in an essentially autocrine fashion in these transgenic animals.
Rauwolfia Alkaloids. XIV. Derivatives of Yohimbé Alkaloids (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRauwolfia Alkaloids. XIV. Derivatives of Yohimbé AlkaloidsCharles F. Huebner, R. Lucas, H. B. MacPhillamy, and Hyla Ames TroxellCite this: J. Am. Chem. Soc. 1955, 77, 2, 469–472Publication Date (Print):January 1, 1955Publication History Published online1 May 2002Published inissue 1 January 1955https://pubs.acs.org/doi/10.1021/ja01607a074https://doi.org/10.1021/ja01607a074research-articleACS PublicationsRequest reuse permissionsArticle Views269Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fabrication of high-aspect-ratio polymer-based electrostatic comb drives using the hot embossing technique (2003)

We report on the formation of a lateral comb drive on poly-methyl-meth-acrylate (PMMA) using the hot embossing technique. A hot embossing mold insert is fabricated on a silicon wafer by means of lithography and inductive coupled plasma dry etching. The comb drive microstructure is hot embossed under a molding force of 35000 N at 130 °C. We demonstrate the comb drive, 80 units of interdigitated parallel capacitors with the finger gap and width both being 10 μm. The minimum feature size is 5 μm and the thickness of the structure is 60 μm, which makes the aspect ratio 12:1. The comb drive strokes 5 μm under an actuation potential of 180 V. We also present a brief description of the design and simulation with ANSYS.
STAT3 and MAPK in human lung cancer tissues and suppression of oncogenic growth by JAB and dominant negative STAT3 (2004)

To search for the signaling events in lung carcinoma relevant to its tumorigenesis, we investigated the phosphorylation of MAPK and STAT3 in human lung carcinoma tissues and their paired normal tissues. Although relative amounts of MAPK levels differed among the cases examined, no clear difference in MAPK levels was observed between tumor tissues and their paired normal tissues. Of 79 cases examined, only 7 cases (8.9%) showed tumor-specific phosphorylation of MAPK, whereas 41 cases (52%) showed more than 2-fold lower levels of MAPK phosphorylation in tumor tissues. In contrast to MAPK, 42 cases (53%) showed tumor-specific increase in STAT3 expression. In addition, 15 cases (19%) showed tumor-specific increase of STAT3 phosphorylation and 51 cases (65%) had STAT3 phosphorylation proportional to its expression. Moreover, exogenous expression of either JAB or dominant negative STAT3 in lung carcinoma cell lines led to the suppression of STAT3 phosphorylation and the drastic reduction of anchorage- independent growth of the cells. Taken together, our results suggest that JAK-STAT3 signaling has a pivotal role for oncogenic growth of lung carcinoma cells.
In vivo adenovirus-mediated gene transfer into ocular tissues. (1994)

Replication-deficient adenoviruses have been successfully used to transfer foreign DNA into a variety of cells including post-mitotic cells, in vivo. In the eyes, most of the cells are quiescent or slowly dividing. They constitute the obligatory targets of gene transfer for a number of ocular diseases that have been elucidated at the molecular level and are potential targets for gene therapy. We have therefore analysed the ability of an adenovirus vector to transfer in vivo the Escherichia coli lacZ gene into ocular cells of mice. Injection of up to 3 x 10(7) p.f.u. into the vitreous body, the anterior chamber or the peribulbar space, did not result in any detectable cytopathic effect and was associated with endocytosis of viral particles in corneal endothelial, photoreceptor, bipolar, ganglionic and oculomotor muscle cells, depending on the administration route. At the viral titer used (3 x 10(7) p.f.u.), the expression was detected for at least 50 days. These results open new prospects for the treatment of some retinal hereditary disorders and acquired corneal or retinal alterations due to inflammatory disease.