gebhart/patrepeval huggingface dataset:
Hirudins: From Leeches to Man (1996)

Hirudins are a group of highly homologous polypeptides from the medicinal leech, Hirudo medicinalis. They have an extremely high and specific affinity for thrombin and are consequently potent anticoagulants. They inhibit platelet aggregation induced by thrombin and efficiently inhibit thrombin when it is bound to a fibrin clot. Recombinant hirudins have now been produced and have been used to show a wide range of effects on thrombosis in animal models. They are particularly effective against venous-type thrombi and have greater effects than heparins on the platelet-rich thrombi in arteries. Recombinant hirudins are currently undergoing clinical trails in deep venous thrombosis and acute coronary syndrome and as an adjunct to thrombolysis in myocardial infarction. Results from pilot trials indicate promising advantages over the currently used antithrombotic agents. Larger clinical trails have been initiated and we await with great interest their imminent publication.
Glucose Metabolism of Human Prostate Cancer Mouse Xenografts (2005)

We hypothesized that the glucose metabolism of prostate cancer is modulated by androgen. We performed in vivo biodistribution and imaging studies of [F-18] fluorodeoxyglucose (FDG) accumulation in androgen-sensitive (CWR-22) and androgen-independent (PC-3) human prostate cancer xenografts implanted in castrated and noncastrated male athymic mice. The growth pattern of the CWR-22 tumor was best approximated by an exponential function (tumor size in mm3 = 14.913 e(0.1086 x days), R2 = .96, n = 5). The growth pattern of the PC-3 tumor was best approximated by a quadratic function (tumor size in mm3 = 0.3511 x days2 + 49.418 x day - 753.33, R2 = .96, n = 3). The FDG accumulation in the CWR-22 tumor implanted in the castrated mice was significantly lower, by an average of 55%, in comparison to that implanted in the noncastrated host (1.27 vs. 2.83, respectively, p < .05). The 3-week maximal standardized uptake value (SUVmax) was 0.99 +/- 0.43 (mean +/- SD) for CWR-22 and 1.21 +/- 0.32 for PC-3, respectively. The 5-week SUVmax was 1.22 +/- 0.08 for CWR-22 and 1.35 +/- 0.17 for PC-3, respectively. The background muscle SUVmax was 0.53 +/- 0.11. Glucose metabolism was higher in the PC-3 tumor than in the CWR-22 tumor at both the 3-week (by 18%) and the 5-week (by 9.6%) micro-PET imaging sessions. Our results support the notions that FDG PET may be useful in the imaging evaluation of response to androgen ablation therapy and in the early prediction of hormone refractoriness in men with metastatic prostate cancer.
Diabetes and Cardiovascular Disease (1979)

Based on 20 years of surveillance of the Framingham cohort relating subsequent cardiovascular events to prior evidence of diabetes, a twofold to threefold increased risk of clinical atherosclerotic disease was reported. The relative impact was greatest for intermittent claudication (IC) and congestive heart failure (CHF) and least for coronary heart disease (CHD), which was, nevertheless, on an absolute scale the chief sequela. The relative impact was substantially greater for women than for men. For each of the cardiovascular diseases (CVD), morbidity and mortality were higher for diabetic women than for nondiabetic men. After adjustment for other associated risk factors, the relative impact of diabetes on CHD, IC, or stroke incidence was the same for women as for men; for CVD death and CHF, it was greater for women. Cardiovascular mortality was actually about as great for diabetic women as for diabetic men. (<i>JAMA</i>241:2035-2038, 1979)
Evolutionary relationship of Rickettsiae and mitochondria (2001)

Phylogenetic data support an origin of mitochondria from the alpha-proteobacterial order Rickettsiales. This high-rank taxon comprises exceptionally obligate intracellular endosymbionts of eukaryotic cells, and includes family Rickettsiaceae and a group of microorganisms termed Rickettsia-like endosymbionts (RLEs). Most detailed phylogenetic analyses of small subunit rRNA and chaperonin 60 sequences consistently show the RLEs to have emerged before Rickettsiaceae and mitochondria sister clades. These data suggest that the origin of mitochondria and Rickettsiae has been preceded by the long-term mutualistic relationship of an intracellular bacterium with a pro-eukaryote, in which an invader has lost many dispensable genes, yet evolved carrier proteins to exchange respiration-derived ATP for host metabolites as envisaged in classic endosymbiont theory.
Synthesis of 2',3'-Dideoxy-D-erythro-hex-2'-enopyranosyl Nucleosides from 5-Aminouracils and 3,4,6-Tri-O-acetyl-D-glucal (1992)

Condensation of silylated N,Ndisubstituted aminouracils (4) and 3,4,6-tri-@acetyl-D-glucal (3) in the presence of TMS triflate as catalyst gave anomeric mixtures of 2',3'dideoxy-D-rythrohex-2'-enopyranosylnucleosides (5) and ( 6).The pure fi and nanomers were separated by chromatography and deprotected with a saturated solution of ammonia in methanol to give 1- (2',3'dideoxy-fiD-erythroh~-2~nopyranosyl)nou1acils (7) and their corresponding w anomers (a), respectively.The anomeric configurations of these nucleosides were assigned by nmr analysis of the &hydro derivatives 9 and 10 obtained by hydrogenation of 7a and 8a, respective ly.No significant acitivity against HIV-1 was found.Important advances1 in virus chemotherapy have been made during the last few years using a variety of compounds with potent and selective antiviral activity.lS2This search has been further promoted by the advent of AIDS (acquired immunodeficiency syndrome) and the identification of a retrovirus, now termed human immunodeficiency virus (HIV), as the causative agenL3 Nevertheless, there is a permanent need for an effective antiviral research towards new and more potent or selective drugs.Various nucleoside derivatives having double bonds between C-2 and C-3 of the sugar portions are known to have antibiotic acitivity.*In AIDS therapy, the main interest of unsaturated compounds has been focused on furanosyl nucleosides: whereas the interest in pyranosyl analogues has been stimulated by Blasticidin S being a 2'-enopyranosylcytosine with antibiotic and antitumoral activity."nother important application of Blasticidin S is its action as fungicide against rice blast disease in Japan.'In this paper we describe a series of new N,Ndisubstituted 5-aminouracils and their corresponding 2',3'-unsaturated pyranosyl nucleosides that may have interesting biological activities.
Biological characterization of a novel biodegradable antimicrobial polymer synthesized with fluoroquinolones (2001)

Biomaterial-related infections continue to represent a significant challenge to the medical community. Several approaches have been utilized to incorporate antimicrobial agents at the surface of implant devices in attempts to delay or eliminate the formation of biofilms. To date, most of these strategies have focused on drug conjugation or diffusion-limited systems for the delivery of such pharmaceutical agents. More recently, work has been presented on the feasibility of incorporating drugs into the backbone of polymers as a main-chain monomer. When sequenced into the backbone of the polymer with other monomers that are hydrolytically sensitive to enzyme-catalyzed breakdown, it is thought that drugs may be able to be selectively released. Specifically, degradable polyurethanes have been synthesized with fluoroquinolone antibiotics and have shown an ability to kill bacteria when released following degradation of the polymer chains by the macrophage-derived enzyme cholesterol esterase. However, specificity of the cleavage sites in the polymer was difficult to control. Since cholesterol esterase has specificity for hydrophobic moieties, it is desirable to alter the formulation of the polyurethanes to incorporate long hydrophobic monomers immediately adjacent to the ciprofloxacin molecule. Hence, the current study focuses on evaluating the enzyme-catalyzed degradation of a degradable polyurethane synthesized with 1,12 diisocyanatododecane as a substitute for 1,6 diisocyanatohexane, which was used in previous work. Validation of specific ciprofloxacin release and the generation of antimicrobial are shown. A preliminary cell study to assess the cytotoxicity of this biodegradable antibiotic polymer shows that the material has no observable effects on cell proliferation or cell membrane structure.
The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network (2001)

Many intracellular vesicle transport pathways involve GTP hydrolysis by the ADP-ribosylation factor (ARF) type of monomeric G proteins, under the control of ArfGAP proteins. Here we show that the structurally related yeast proteins Gcs1 and Age2 form an essential ArfGAP pair that provides overlapping function for TGN transport. Mutant cells lacking the Age2 and Gcs1 proteins cease proliferation, accumulate membranous structures resembling Berkeley bodies, and are unable to properly process and localize the vacuolar hydrolase carboxypeptidase (CPY) and the vacuolar membrane protein alkaline phosphatase (ALP), which are transported from the TGN to the vacuole by distinct transport routes. Immunofluorescence studies localizing the proteins ALP, Kex2 (a TGN resident protein), and Vps10 (the CPY receptor for transport from the TGN to the vacuole) suggest that inadequate function of this ArfGAP pair leads to a fragmentation of TGN, with effects on secretion and endosomal transport. Our results demonstrate that the Gcs1 + Age2 ArfGAP pair provides overlapping function for transport from the TGN, and also indicate that multiple activities at the TGN can be maintained with the aid of a single ArfGAP.
[The role of pharmacological tests in detecting disorders in the bronchial patency and bronchial reactivity of patients with chronic glomerulonephritis]. (1992)

Data are reported of a study of the effect of atrovent, salbutamol and acetylcholine on bronchial patency and reactivity of the bronchi in 89 patients with glomerulonephritis (age: 17-49 years) with normal renal function and at the stage of chronic renal failure. The tests proved highly informative. Latent bronchospasm was found in 12.1% of patients with chronic glomerulonephritis. In 76.3% of patients at the stage of chronic renal failure hyperreactivity of the bronchi was found. The revealed changes require early diagnosis and treatment.
Inhibition of theophylline metabolism by long-term allopurinol administration (1981)

Administration of an oral dose of allopurinol (300 mg every 12 hr) for 14 consecutive days increased the mean theophylline area under the curve (AUC) 27% and mean theophylline half-life (t1/2) 25%, whereas the mean theophylline clearance (Cl) decreased 21%. Allopurinol did not alter either apparent volume of distribution (aVd) or gastrointestinal absorption (Cmax and tmax) of theophylline. After 28 consecutive days of allopurinol administration, theophylline disposition was the same as that on day 14. Thus, given in a dose of 300 mg every 12 hr for 14 or 28 days, allopurinol inhibits theophylline metabolism, despite the failure of allopurinol in lower doses given for only 7 days to alter theophylline disposition. These results emphasize the need to investigate several different doses and durations of administration within therapeutic ranges before firm conclusions can be drawn concerning the influence of one drug on the disposition of another.
The P2X7receptor as a therapeutic target (2008)

We describe the recent discoveries of novel P2X(7) receptor-selective antagonists, along with their biological activity and therapeutic potential.
The effect of azelastine on the early allergic response (1992)

To study the effect of azelastine on the immediate reaction to nasal allergen challenge, we performed a double blind, placebo-controlled cross-over clinical trial. Thirteen subjects with seasonal allergic rhinitis underwent nasal challenge with antigen 4 hr after a single oral 2 mg dose of azelastine. The response was monitored by counting the number of sneezes and by measuring the levels of histamine, prostaglandin D2, immunoreactive sulphidopeptide leukotrienes, kinis and TAME-esterase activity in recovered nasal lavages. After a single dose of azelastine, there was a significant reduction in sneezing (10 vs 2, P = 0.01) and in the median levels of recovered TAME-esterase activity (63.1 vs 17.5 c.p.m. x 10(-3), P = 0.01), immunoreactive sulphidopeptide leukotrienes (7.5 vs 2.1 ng/ml, P = 0.03) and kinins (1370 vs 251 pg/ml, P = 0.03), with no significant reduction in the median levels of histamine (3.7 vs 1.2 ng/ml, P = 0.2) and prostaglandin D2 (70 vs 70 pg/ml, P = 0.2) compared to placebo (numbers represent total increase over diluent challenge). These results suggest that azelastine does not inhibit mast cell activation but affects the consequences of released histamine, namely sneezing, increased vascular permeability and the generation of kinins. The results further suggest that other cells, in addition to mast cells, might be responsible for the generation of leukotrienes during the early allergic response, and that azelastine reduces their ability to generate this mediator or that inhibition of leukotriene release from mast cells occurs at lower drug concentrations.
Modeling Message Roles and Influence in Q&A Forums (2010)

We are modeling roles of individual messages and participants in Q&A discussion forums. In this paper, we present a mixed network model that represents message exchanges and message influences within a discussion thread. We first model individual message roles and thread-level user roles using discussion content features. We then combine the resulting message roles and the user roles to generate the overall influence network. Message influences and their aggregation over the network are analyzed using B-centrality measures. We use the results in identifying the most influential message in answering the initial question of the thread.
Cross-layer QoS and its application in congestion control (2010)

The paper proposes a preliminary design of cross-layer quality of service applied to congestion control in future Internet. This is an alternative solution to QoS-aware routing, whenever the infrastructure operator cannot add new resources, and/or when re-routing is not possible. Dedicated software, running in each node, collects a list of local parameters such as available transfer rate and one-way delay between all neighbors. Then this real-time status information is distributed to all the in-network management enabled nodes that are allowed to be reached. Due to the statistics regarding individual link traffic, a minimal network coding scheme, triggered by cross-layer quality of service, is temporarily activated. This system presents an enhanced distributed routing that preserves the performances of the running services, despite the congestion which cannot be eliminated.
Safety and Immunogenicity of Low and High Doses of Trivalent Live Cold‐Adapted Influenza Vaccine Administered Intranasally as Drops or Spray to Healthy Children (1998)

The safety and immunogenicity of various doses of trivalent cold-adapted influenza vaccine (CAIV-T) administered intranasally by drops or spray to children aged 18-71 months was examined. CAIV-T containing A/Johannesburg/33/94 (H3N2), B/Panama/45/90, and A/Texas/36/91 (H1N1) was safe and well-tolerated. At the highest CAIV-T dose, 90%, 50%, and 16% of initially seronegative subjects seroconverted to the H3N2, B, and H1N1 antigens, respectively. The lower immunologic response to the H1N1 vaccine strain compared with the other strains was associated with a low frequency of H1N1 shedding. No statistically significant differences in reactogenicity or immunogenicity were detected between subjects who received CAIV-T by drops or spray. In conclusion, this CAIV-T was safe and induced acceptable immunologic responses to 2 of the 3 vaccine strains. Studies are needed to confirm previous observations that receipt of two doses of this vaccine results in immunologic responses that confer protection to all 3 circulating influenza virus strains.
Ranibizumab in neovascular age-related macular degeneration (2006)

Neovascular age-related macular degeneration (AMD) is a visually devastating condition resulting from choroidal neovascularization and secondary photoreceptor loss. Ranibizumab and bevacizumab are medications that target vascular endothelial growth factor (VEGF). While other therapies have demonstrated some ability to reduce the risk of losing vision from neovascular AMD, most patients continue to lose some degree of central visual acuity. There is growing evidence that intravitreal administration of ranibizumab and bevacizumab is effective in significantly improving the visual acuity in patients with neovascular age-related macular degeneration.
Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study (2014)

Low ScvO2 was common in the first hours of admission to the ICU for severe sepsis or septic shock even when clinical resuscitation endpoints were achieved and even when arterial lactate was normal. A ScvO2 below 70% in the first hours of ICU admission and six hours later was associated with day-28 mortality.
Efficacy and Safety of CE-224,535, an Antagonist of P2X7Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate (2012)

CE-224,535 was not efficacious, compared with placebo, for the treatment of RA in patients with an inadequate response to MTX. CE-224,535 demonstrated an acceptable safety and tolerability profile.
HOE-39866 use in Chemical Fallow Systems (1989)

Studies were conducted to determine the usefulness of HOE-39866 (HOE-00661) in chemical fallow systems on the Canadian prairies. HOE-39866 at 0.5 to 1.0 kg ai/ha controlled Russian thistle, kochia, green foxtail, wild oats, and wheat comparable to paraquat, glyphosate, and glyphosate plus the isopropylamine salt of 2,4-D. However, control of barley with HOE-39866 was unacceptable. HOE-39866 was compatible in tank mixtures with ammonium sulfate, paraquat, chlorsulfuron, and metsulfuron. Ammonium sulfate improved weed control when HOE-39866 was applied at 0.25 kg/ha but not at 0.75 kg/ha. Adding paraquat at 0.07 to 0.21 kg ai/ha to HOE-39866 improved control of grass species over HOE-39866 alone. Adding chlorsulfuron and metsulfuron to HOE-39866 provided greater initial control of certain species as well as residual control of many weeds. HOE-39866 alone or in conjunction with other herbicides is an alternative to the herbicides used in chemical fallow systems.
Erasable Optical Storage in Bistable Liquid Crystal Cells (1992)

In this paper, we present a new kind of bistable liquid crystal display (Filled Nematic) using static light scattering, and its application as a high resolution laser-addressed display. The new material consists of small inorganic particles dispersed in a nematic liquid crystal. In dispersion the particles form internal interfaces with a large specific surface making it possible to stabilize different director configurations. We report the key parameters for reversible optical data storage in this medium and give a first explanation of the physical mechanism of the laser-writing process.
Functional analysis of NsrR, a nitric oxide‐sensing Rrf2 repressor in Neisseria gonorrhoeae (2008)

Nitric oxide (NO) has been shown to be an important component of the human immune response, and as such, it is important to understand how pathogenic organisms respond to its presence. In Neisseria gonorrhoeae, recent work has revealed that NsrR, an Rrf2-type transcriptional repressor, can sense NO and control the expression of genes responsible for NO metabolism. A highly pure extract of epitope-tagged NsrR was isolated and mass spectroscopic analysis suggested that the protein contained a [2Fe-2S] cluster. NsrR/DNA interactions were thoroughly analysed in vitro. Using EMSA analysis, NsrR::FLAG was shown to interact with predicted operators in the norB, aniA and nsrR upstream regions with a K(d) of 7, 19 and 35 nM respectively. DNase I footprint analysis was performed on the upstream regions of norB and nsrR, where NsrR was shown to protect the predicted 29 bp binding sites. The presence of exogenously added NO inhibited DNA binding by NsrR. Alanine substitution of C90, C97 or C103 in NsrR abrogated repression of norB::lacZ and inhibited DNA binding, consistent with their presumed role in co-ordination of a NO-sensitive Fe-S centre required for DNA binding.
Metallindikatoren II. Beziehungen zwischen Struktur und Komplexbildungsvermögen bei Verwandten des Murexids (1949)

Abstract 1. Methin‐bis‐barbitursäure (Ia), Methin‐bis‐(1,3‐dimethyl‐barbitursäure) (IIa) und Barbituryl‐azin‐(4‐methyl‐uracil) (VIII) wurden in reinem Zustande erhalten und charakterisiert. In Lösung konnte der sehr unbeständige Farbstoff: Azin‐bis‐dimedon (III) erhalten und untersucht werden. Weiter wurden das Reduktionsprodukt von Ia, die Methylen‐bis‐barbitursäure, sowie die äthylen‐bis‐barbitursäure erstmals dargestellt und charakterisiert.
An interactive graphics display architecture (2002)

A technique for redesigning a display controller within a traditional graphics display system is outlined. By performing complicated computations within the display controller, the system may be optimized for the needs of a virtual reality display system. Wide angle viewing lens effects and response to user head rotations may be compensated for within the display controller, avoiding the rendering bottleneck. The architecture allows image overlaying to provide more realistic scenes and a mechanism for focusing the time of the rendering engine on sections of the scene which change the most frequently.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Chemists Seek Greater Recognition for Catalysis (1993)

RETURN TO ISSUEPREVNewsNEXTChemists Seek Greater Recognition for Catalysis▪ Catalysis Society meeting mulls over international efforts to increase funding, gain direction for the disciplineJOSEPH HAGGINView Author Information C&EN ChicagoCite this: Chem. Eng. News 1993, 71, 22, 23–27Publication Date (Print):May 31, 1993Publication History Published online12 November 2010Published inissue 31 May 1993https://pubs.acs.org/doi/10.1021/cen-v071n022.p023https://doi.org/10.1021/cen-v071n022.p023newsACS PublicationsCopyright © 1993 American Chemical SocietyArticle Views521Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Catalysis Get e-Alerts