gebhart/patrepeval huggingface dataset:
Machine prognostics based on health state estimation using SVM (2008)

The ability to accurately predict the remaining useful life of machine components is critical for continuous operations in machines which can also improve productivity and enhance system safety. In condition-based maintenance (CBM), effective diagnostics and prognostics are important aspects of CBM which provide sufficient time for maintenance engineers to schedule a repair and acquire replacement components before the components finally fail. All machine components have certain characteristics of failure patterns and are subjected to degradation processes in real environments. This paper describes a technique for accurate assessment of the remnant life of machines based on prior expert knowledge embedded in closed loop prognostics systems. The technique uses Support Vector Machines (SVM) for classification of faults and evaluation of health for six stages of bearing degradation. To validate the feasibility of the proposed model, several fault historical data from High Pressure Liquefied Natural Gas (LNG) pumps were analysed to obtain their failure patterns. The results obtained were very encouraging and the prediction closely matched the real life particularly at the end of term of the bearings.
The ice/water interface: Molecular dynamics simulations of the basal, prism, {2021}, and {2110} interfaces of ice Ih (2001)

The structure and dynamics of the {0001} (basal), {101̄0} (prism), {202̄1}, and {21̄1̄0} ice Ih/water interfaces have been investigated using molecular dynamics and the flexible CF1 central force model of water. The translational order profile, the average density profile, and the diffusion profile have been calculated for all four interfaces as a function of distance normal to the interface. Dynamical molecular trajectories have been used to explore the loss of translational order from within the crystal region, through the interface, and into the liquid region. The thickness of the interfaces has been determined from each order parameter and compared with results from rigid models of water and experiment. The high index faces have thinner interfacial regions than the basal and prism interfaces. All interfacial regions contain molecules that are neither ice-like nor water-like.
Emergency and Compassionate‐Use INDs and Accelerated NDA or ANDA Approvals—Procedures, Benefits and Pitfalls (2002)

This chapter contains sections titled: Emergency INDs ‘Compassionate Use’: the Treatment IND Accelerated Approvals: Serious and Life-Threatening Diseases Accelerated Approvals: ANDAs and Generic Drugs References
Characterization of the T cell recognition of hepatitis B surface antigen (HBsAg) by good and poor responders to hepatitis B vaccines (2000)

To study the regulation of the human cellular immune response to HBsAg we produced a series of HBsAg-specific T cell lines from good and poor responders to the hepatitis B vaccine. All T cell lines expressed CD4 on their membrane and could therefore be considered of the helper/inducer phenotype. The different HBsAg-specific T cell lines were restricted by HLA-DRB5*0101, DRB1*1201, -DRB1*0701, -DRB1*0301, -DPB1*0201, -DPB1*0402, and -DPB1*0901. In good responders to the hepatitis B vaccine different HLA molecules could act as restricting element. In poor responders the diversity of HLA class II restriction determinants was more limited. This leads us to conclude that the immune response to HBsAg is multispecific and polyclonal in good responders and paucispecific and oligoclonal in poor responders to the hepatitis B vaccine. By using a panel of synthetic peptides representing selected sequences of the HBsAg, the fine specificities of each of these T cell lines could be determined. Strikingly, the majority of the identified T cell epitopes was located in and around the first hydrophobic transmembranous region of the HBsAg. This was observed in T cell lines from good and poor vaccine responders, without distinction. The remarkable T cell immunogenicity of this region may reside in its richness in binding motifs for a variety of HLA class II determinants.
Minerals in Whey and Whey Fractions (1978)

Liquid and dried acid and sweet wheys and the concentrates and permeates obtained from ultrafiltration of whey were analyzed for major and trace minerals. Calcium, magnesium, sodium, and potassium were determined by atomic absorption and phosphorus by a colorimetric method. Zinc, iron, copper, and manganese were determined by flameless atomic absorption. The composition of all wheys and their fractions differed in nutritionally important minerals. Calcium was three times as great and zinc twenty times as great in acid whey as in sweet whey.
Fibronectin and alpha5 integrin regulate keratinocyte cell cycling. A mechanism for increased fibronectin potentiation of T cell lymphokine-driven keratinocyte hyperproliferation in psoriasis. (1998)

In addition to being T lymphocyte-driven, psoriasis may be due in part to abnormal integrin expression. Normal-appearing (uninvolved) skin from psoriatic patients was examined to determine whether altered fibronectin or its receptor expression is detectable before development of psoriatic lesions. In contrast to skin from normal subjects, we detect by immunofluorescence the abnormal presence of plasma fibronectin in the basal cell layer of the epidermis of psoriatic uninvolved skin. Furthermore, increased fibronectin exposure superinduces the in vitro cell cycle induction and expansion of psoriatic nonlesional keratinocytes in response to a cocktail of T cell lymphokines. Fibronectin alone also appeared to increase cell cycle entry among uninvolved but not normal keratinocytes. Concordantly, the alpha5 integrin fibronectin receptor, but not alpha2 or alpha3, is overexpressed in the in vivo nonlesional psoriatic epidermis. The involvement of alpha5beta1 in the early outgrowth of clonogenic keratinocytes in the ex vivo culture was demonstrated by the ability of anti-alpha5 mAb to inhibit keratinocyte growth on fibronectin. Thus, the fibronectin receptor appears to be one of the components required for the development of the hyperresponsiveness of psoriatic keratinocytes to signals for proliferation provided by lymphokines produced by intralesional T lymphocytes in psoriasis.
Estimating Potential Transpiration of Apple Trees Using Theoretical Non-Water-Stressed Baselines (2015)

To maximize irrigation efficiency, applied water has to be precisely adjusted to the crop water use. This study develops a method based on the energy balance of a single apple leaf to calculate potential transpiration (Ep) for the whole apple tree. The Ep model was based on two main submodels predicting canopy temperature (Tc) and total canopy conductance (gT). The gT model was derived by simplifying the energy budget to rely on only climatic data and an empirical coefficient. These submodels were evaluated using the canopy temperature data collected in a Fuji apple orchard during the 2007, 2008, and 2013 growing seasons. The applicability of the Ep model was examined on (1) well-watered, young Fuji apple trees, and (2) well-irrigated, older apple trees bearing little fruit. Predicted potential transpiration rates at both scenarios were compared with those predicted by the ASCE standardized Penman–Monteith values for alfalfa (ETr). Daily average weather data collected during the three growing seasons provided the inputs to the Ep model and its components. With the exception of air temperature measured in the orchard, the rest of the meteorological data were obtained from a local weather station. The canopy temperatures of the fully watered trees were predicted during midseason with mean absolute errors (MAEs) of about 0.41, 0.33, and 0.23°C in 2007, 2008, and 2013, respectively. These MAEs were better than the individual IRT accuracy of ±0.6°C. The coefficient of variation (CV) of the predictions averaged 2% over the experiment plots/years, being better than that of the measurements (CV=4.8%) with the exception of one plot in 2007 with little difference (3% versus 2%). Ep was fairly correlated with ETr on warm and dry days (R2=0.58, p<0.001) with slope and intercept values of close to 1.0 and 0.0, respectively. The model was able to reflect the high degree of coupling between the apple trees and the humidity of the surrounding air during cold and humid periods as Ep resulted in significantly lower values. The overall results of the experiments with Fuji apple trees showed that the non-water-stressed baselines and potential transpiration of Fuji apple trees can be estimated using the proposed approach.
[Comparison study on total flavonoid content and anti-free redical activity of the leaves of bamboo, phyllostachys nigra, and Ginkgo bilabo]. (2002)

The TF content and anti-free radical activity the bamboo leaf are comparable with the leaf of ginkgo biloba, which is a kind of potential resources for natural antioxidant and free radical scavenger.
VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION (2005)

As the global eradication of wild poliovirus nears, the World Health Organization (WHO) is addressing challenges unprecedented in public health. The live, attenuated oral poliovirus vaccine (OPV), used for more than four decades to interrupt poliovirus transmission, and the vaccine of choice for developing countries, is genetically unstable. Reversion of the small number of substitutions conferring the attenuated phenotype frequently occurs during OPV replication in humans and is the underlying cause of the rare cases of vaccine-associated paralytic poliomyelitis (VAPP) in OPV recipients and their close contacts. Whereas VAPP has long been recognized, two other adverse events have been identified more recently: (a) long-term excretion of highly evolved vaccine-derived polioviruses (VDPVs) in persons with primary immunodeficiencies, and (b) polio outbreaks associated with circulating VDPVs in areas with low rates of OPV coverage. Developing a posteradication strategy to minimize the risks of VDPV emergence and spread has become an urgent WHO priority.
Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine inalkB Escherichia coli (2004)

AlkB repairs 1-alkyladenine and 3-methylcytosine lesions in DNA by directly reversing the base damage. Although repair studies with randomly alkylated substrates have been performed, the miscoding nature of these and related individually alkylated bases and the suppression of mutagenesis by AlkB within cells have not yet been explored. Here, we address the miscoding potential of 1-methyldeoxyadenosine (m1A), 3-methyldeoxycytidine (m3C), 3-ethyldeoxycytidine (e3C), 1-methyldeoxyguanosine (m1G), and 3-methyldeoxythymidine (m3T) by synthesizing single-stranded vectors containing each alkylated base, followed by vector passage through Escherichia coli. In SOS(-), AlkB-deficient cells, m1A was only 1% mutagenic; however, m3C and e3C were 30% mutagenic, rising to 70% in SOS(+) cells. In contrast, the mutagenicity of m1G and m3T in AlkB(-) cells dropped slightly when SOS polymerases were expressed (m1G from 80% to 66% and m3T from 60% to 53%). Mutagenicity was abrogated for m1A, m3C, and e3C in wild-type (AlkB(+)) cells, whereas m3T mutagenicity was only partially reduced. Remarkably, m1G mutagenicity was also eliminated in AlkB(+) cells, establishing it as a natural AlkB substrate. All lesions were blocks to replication in AlkB-deficient cells. The m1A, m3C, and e3C blockades were completely removed in wild-type cells; the m1G blockade was partially removed and that for m3T was unaffected by the presence of AlkB. All lesions demonstrated enhanced bypass when SOS polymerases were induced. This work provides direct evidence that AlkB suppresses both genotoxicity and mutagenesis by physiologically realistic low doses of 1-alkylpurine and 3-alkylpyrimidine DNA damage in vivo.
Differential stimulation of sea urchin early and late H2B histone gene expression by a gastrula nuclear extract after injection into Xenopus laevis oocytes. (1988)

Sea urchin early histone genes are active in preblastula embryos; late histone genes are maximally expressed during subsequent stages of embryogenesis. We used the Xenopus laevis oocyte to assay for trans-acting factors involved in this differential regulation. Sea urchin nuclear proteins were prepared by extracting gastrula-stage chromatin successively with 0.45, 1, and 2 M NaCl. We injected three fractions into oocytes along with plasmids bearing sea urchin early and late H2b histone genes. While neither the 0 to 0.45 M nor the 1 to 2 M salt fraction affected H2b gene expression, the 0.45 to 1 M salt fraction stimulated early and late H2b mRNA levels significantly. Late H2b gene expression was stimulated preferentially when the early and late genes were coinjected into the same oocytes. This extract did not stimulate the accumulation of transcripts of injected herpesvirus thymidine kinase genes or of the sea urchin Spec 1 gene, suggesting that the stimulatory activity is not a general transcription factor. We localized the DNA sequence required for the stimulatory effect to a region of the late H2b gene located between -43 and +62 relative to the transcription start site. A component of the 0.45 to 1 M salt wash fraction specifically bound to the 105-base-pair late gene DNA sequence and to the corresponding early gene fragment. The abundance of this binding activity decreased on a per genome basis during early development of the sea urchin.
On the Computation of the Discrete Cosine Transform (1978)

An <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> -point discrete Fourier transform (DFT) algorithm can be used to evaluate a discrete cosine transform by a simple rearrangement of the input data. This method is about two times faster compared to the conventional method which uses a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2N</tex> -point DFT.
Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis (2002)

EGFRvIII was first reported in human glioblastomas. Subsequent reports indicated EGFRvIII protein to be frequently detected in several other human cancers, but not in normal tissues. Our previous studies suggested that EGFRvIII could induce a transformation from ligand-dependent non-tumorigenic cell line to ligand-independent malignant phenotype cells in vitro and in vivo. Transfection of EGFRvIII in MCF-7 cell line resulted in a 3-fold increase in colony formation and significantly enhanced tumorigenicity in nude mice (p < 0.001). EGFRvIII could also induce ErbB-2 phosphorylation. The existence and significance of EGFRvIII transcript in human breast cancer, however, was not reported. In our study, we detected the presence of EGFRvIII mRNA and revealed a high incidence (67.8%) of EGFRvIII transcript in human primary invasive breast cancer by utilizing laser capture microdissection (LCM)/RT-PCR to capture pure breast cancer cells. In addition, 57.1% of the infiltrating breast carcinomas expressed both EGFRwt and EGFRvIII mRNA in the same tumor. There is no detectable EGFRvIII mRNA in normal breast tissue. Evaluation of the EGFRwt and EGFRvIII protein levels in the same sample sets by immunohistochemical analysis further confirmed the LCM/RT-PCR finding. Our study provides first direct evidence of high incidence of coexpression of EGFRvIII and EGFRwt in human invasive breast cancer tissue. The unique characteristics and high prevalence of EGFRvIII in invasive human breast cancer as well as negative expression in normal breast may suggest its important role in breast carcinogenesis and make it an ideally potential target for treatment of breast cancer without interrupting normal EGFR signaling.
Fine-granularity loading schemes using adaptive Reed-Solomon coding for discrete multitone modulation systems (2005)

In this paper, we present a fine granularity loading scheme using joint optimization of modulation and coding for discrete multitone (DMT) modulation towards achieving maximum information rate conveyed. While most existing algorithms strived for the optimal energy distribution to maximize rate, the bits loaded were always constrained to integers. It was initially believed that most (not all) of the granularity losses could be recovered through 'bit-rounding' and 'energy re-scaling' after an optimal 'water-filling' approach. But this was observed only for the total power constrained case. With the advent of peak power constraint, we show that the room for optimization in the energy domain severely constrained and granularity losses constitute a significant percentage of the achievable data rate. To recover these losses, we propose a loading scheme that integrates the coding scheme with the bit-loading algorithm. For achieving near-continuous rate adaptation, the family of Reed-Solomon (RS) codes has been used for their low redundancy, high flexibility in correction capability and highly programmable architecture. Simulation results with very high bit rate digital subscriber line (VDSL)-DMT system show more than 20% improvement in most cases.
Stimuli-Controlled Hydrogels and Their Applications (2017)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTStimuli-Controlled Hydrogels and Their ApplicationsItamar WillnerView Author Information The Hebrew University of JerusalemCite this: Acc. Chem. Res. 2017, 50, 4, 657–658Publication Date (Web):April 18, 2017Publication History Published online18 April 2017Published inissue 18 April 2017https://doi.org/10.1021/acs.accounts.7b00142Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views5517Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (165 KB) Get e-AlertsSUBJECTS:Cells,Hydrogels,Materials,Peptides and proteins,Stimuli-responsive Get e-Alerts
Polymer-Free Carbon Nanotube Thermoelectrics with Improved Charge Carrier Transport and Power Factor (2016)

Here, semiconducting single-walled carbon nanotubes (s-SWCNTs) have recently attracted attention for their promise as active components in a variety of optical and electronic applications, including thermoelectricity generation. Here we demonstrate that removing the wrapping polymer from the highly enriched s-SWCNT network leads to substantial improvements in charge carrier transport and thermoelectric power factor. These improvements arise primarily from an increase in charge carrier mobility within the s-SWCNT networks because of removal of the insulating polymer and control of the level of nanotube bundling in the network, which enables higher thin-film conductivity for a given carrier density. Ultimately, these studies demonstrate that highly enriched s-SWCNT thin films, in the complete absence of any accompanying semiconducting polymer, can attain thermoelectric power factors in the range of approximately 400 μW m<sup>-1</sup>K<sup>-2</sup>, which is on par with that of some of the best single-component organic thermoelectrics demonstrated to date.
[Dot-blot analysis in laboratory diagnosis of hemorrhagic fever with renal syndrome]. (1996)

A sensitive micro EIA utilizing antigen or antibody dotted onto nitrocellulose filters (Dot-ELISA, Dot-blot) has been developed for laboratory diagnosis of hemorrhagic fever with the renal syndrome (HFRS) by detecting the virus specific IgM and IgG in the sera of HFRS patients and the antigen in crude lung suspensions of wild rodents. Measurements of specific IgM and IgG in paired HFRS sera collected during the first month of the disease showed clear-cut seroconversion and 100% correlation with the results of immunofluorescent test. The results of antigen detection in lung suspensions of 605 wild rodents trapped in various regions of Russia were identical to standard ELISA results. This rapid and inexpensive test may be useful in early serologic diagnosis of HFRS and in field serological and epizootological studies.
Serum 25-hydroxyvitamin D levels modulate the acute-phase response associated with the first nitrogen-containing bisphosphonate infusion (2009)

The acute-phase response (APR) is the most frequent side effect after the first dose of intravenous nitrogen-containing bisphosphonates (N-BPs). It has been demonstrated in vitro that N-BPs stimulate gammadelta T-cell proliferation and production of cytokines and that vitamin D is able to modulate them. Therefore, we have studied the relationship between bone metabolism parameters, particularly for 25-hydroxyvitamin D [25(OH)D], and APR in patients treated with 5 mg zoledronic acid intravenously. Ninety N-BP-naive osteoporotic women (63.7 +/- 10.6 years of age) were stratified for the occurrence of APR (APR(+)) or not (APR(-)) and quantified by body temperature and C-reactive protein (CRP). The APR(+) women had significantly lower 25(OH)D levels than the APR(-) women. Levels of 25(OH)D were normal (>30 ng/mL) in 31% of APR(+) women and in 76% of APR(-) women. The odds ratio (OR) to have APR in 25(OH)D-depleted women was 5.8 [95% confidence interval (CI) 5.30-6.29; p < .0002] unadjusted and 2.38 (95% CI 1.85-2.81; p < .028) after multiple adjustments (for age, body mass index, CRP, calcium, parathyroid hormone, and C-telopeptide of type I collagen). Levels of 25(OH)D were negatively correlated with postdose body temperature (r = -0.64, p < .0001) and CRP (r = -0.79, p < .001). An exponential increase in fever and CRP has been found with 25(OH)D levels lower than 30 ng/mL and body temperature less than 37 degrees C, whereas normal CRP was associated with 25(OH)D levels above 40 ng/mL. The association between post-N-BPs APR and 25(OH)D suggests an interesting interplay among N-BPs, 25(OH)D, and the immune system, but a causal role of 25(OH)D in APR has to be proven by a randomized, controlled trial. However, if confirmed, it should have some practical implications in preventing APR.