gebhart/patrepeval huggingface dataset:
Application of monoclonal antibodies for endothelin to hypertensive research. (1990)

We developed six kinds of monoclonal antibodies against endothelin (ET)-1 recognizing different epitopes with high affinities (5 x 10(10) M-1 to 5 x 10(11) M-1). Using these monoclonal antibodies, we developed radioimmunoassays for ET-1 with different specificities. Cross-reactivities with ET-2 ranged from 80% to 100%, and those with ET-3 ranged from 3% to 60%. Patients with essential hypertension (n = 20) showed a significant elevation in the plasma ET-1-LI level compared with age-matched control subjects (n = 12) (30.1 +/- 1.4 pg/ml versus 18.5 +/- 0.9 pg/ml, p less than 0.01). The plasma ET-1-LI level in hypertensive patients in stages II and III (World Health Organization classification) was significantly higher than that in those patients in stage I. There was no significant correlation between the plasma ET-1-LI level and systolic blood pressure (r = 0.11), diastolic blood pressure (r = -0.13), or age (r = 0.24) in all patients studied who had essential hypertension. In the neutralization experiment, monoclonal antibodies attenuated ET-1-induced contraction of rat aortic rings and the pressor action of ET-1 in pithed rats in vivo. The present study demonstrates the elevated plasma ET-1-LI level in patients with essential hypertension. Monoclonal antibodies developed in this study can become powerful tools to investigate the pathophysiological significance of ET in essential hypertension.
Metal-Enhanced Fluorescence (MEF) Due to Silver Colloids on a Planar Surface:  Potential Applications of Indocyanine Green to in Vivo Imaging (2003)

We examined the effects of metallic silver colloids on the fluorescence spectral properties of indocyanine green (ICG), which is a dye widely used for in vivo medical testing. Silver colloids from a suspension bind spontaneously to amine-coated surfaces. These colloid-coated surfaces were found to cause a 30-fold increase in the intensity of ICG, which was held close to the metal surface by adsorbed albumin. The increased intensities of ICG were also associated with decreased lifetimes and increased photostability, which are indicative of modifying the fluorophores radiative decay rate. These results suggest the use of metal colloid-enhanced ICG for applications to retinal angiography and vascular imaging and as a contrast agent for optical tomography.
The Present Educational Conditions and the Demanding Outlook of Nursing in Oriental Medicine (1998)

The purpose of this research is to provide basic data for the demanding outlook and the Nursing education by grasping the present educational conditions of nursing in oriental medicine. The results of survey and study on 112 nationwide schools (47 Department of nursing and 65 Nursing junior colleges) and data of the Korean Oriental Medicine Association and General Assembly in Sep. 1998 are as follows. 1. The number of nurse Oriental Medicine hospitals require in 2002 will have increased at least 700 or more. Public health centers' and other centers' requirements will increase more and more. 2. Education of nursing in oriental medicine is offered at practice in 14 universities (29.8%) among 47 Universities and 35 colleges (53.8%) among 65 colleges. 3. Nursing education in Oriental Medicine is mostly offered in the first term of the second year at universities with 5 to 10 points, and the second term of the third year at colleges with 2 points. According to this result, we would like to suggest as follows; A nurse whose main interesting subject is human beings will be an important figure as a medical information administrator in 21 century, namely, a nurse will play the leading part in the hospital administration more than a doctor. We must take much more interest arid exert ourselves in developing education of nursing in oriental medicine because in the future it will be the one and only field in the world, so we can export our Nursing manpower.
Development of a Field Method for Evaluating the Service Life of Organic Vapor Cartridges: Results of Laboratory Testing Using Carbon Tetrachloride (1989)

A new method for determining the service life of respirator cartridges has been developed and tested in a laboratory setting. The method involves using small respirator carbon tubes (RCTs) packed with sorbent obtained from a respirator cartridge of interest. The tubes may be taken into an industrial setting and used to evaluate the work environment. A sample tube is placed directly behind the RCT and periodically replaced. This tube acts as a backup section to the RCT. The sample tube can be brought back to a laboratory and analyzed for the contaminant of interest using validated sampling methods specific for the contaminant. Alternatively, a direct-reading instrument can be placed at the exit end of the RCT to obtain "real-time" breakthrough information. The results, when combined with existing sorbent theories, can be used to predict the service life of a respirator cartridge. The advantage of using RCTs is that, unlike respirator cartridges, they can be taken into the field and used with traditional high-flow air sampling pumps. This method is designed to be able to determine the service life of respirator cartridges even when multiple contaminants are present in the workplace. Results of initial laboratory studies, using carbon tetrachloride as a challenge agent, indicated that RCTs were capable of predicting cartridge service life within an accuracy of +/- 15%.
Crystal Structures of Δ1-Piperideine-2-carboxylate/Δ1-Pyrroline-2-carboxylate Reductase Belonging to a New Family of NAD(P)H-dependent Oxidoreductases (2005)

Delta(1)-Piperideine-2-carboxylate/Delta(1)-pyrroline-2-carboxylate reductase from Pseudomonas syringae pv. tomato belongs to a novel sub-class in a large family of NAD(P)H-dependent oxidoreductases distinct from the conventional MDH/LDH superfamily characterized by the Rossmann fold. We have determined the structures of the following three forms of the enzyme: the unliganded form, the complex with NADPH, and the complex with NADPH and pyrrole-2-carboxylate at 1.55-, 1.8-, and 1.7-A resolutions, respectively. The enzyme exists as a dimer, and the subunit consists of three domains; domain I, domain II (NADPH binding domain), and domain III. The core of the NADPH binding domain consists of a seven-stranded predominantly antiparallel beta-sheet fold (which we named SESAS) that is characteristic of the new oxidoreductase family. The enzyme preference for NADPH over NADH is explained by the cofactor binding site architecture. A comparison of the overall structures revealed that the mobile domains I and III change their conformations to produce the catalytic form. This conformational change plays important roles in substrate recognition and the catalytic process. The active site structure of the catalytic form made it possible to identify the catalytic Asp:Ser:His triad and investigate the catalytic mechanism from a stereochemical point of view.
High operating temperature XBn-InAsSb bariode detectors (2011)

A bariode is a new type of "diode-like" semiconductor photonic device, in which the transport of majority carriers is blocked by a barrier in the depletion layer, while minority carriers, created thermally or by the absorption of light, are allowed to pass freely across the device. In an n-type bariode, also known as an XB<sub>n</sub>n structure, both the active photon absorbing layer and the barrier layer are doped with electron donors, while in a p-type bariode, or XB<sub>p</sub>p structure, they are both doped with electron acceptors. An important advantage of bariode devices is that their dark current is essentially diffusion limited, so that high detector operating temperatures can be achieved. In this paper we report on MWIR n-type bariode detectors with an InAsSb active layer and an AlSbAs barrier layer, grown on either GaSb or GaAs substrates. For both substrate types, the bariodes exhibit a bandgap wavelength of ~ 4.1 &mu;m and operate with Background Limited Performance (BLIP) up to at least 160K at F/3. Different members of the XBnn device family are investigated, in which the contact layer material, "X", is changed between n-InAsSb and p-GaSb. In all cases, the electro-optical properties of the devices are similar, showing clearly the generic nature of the bariode device architecture. Focal Plane Array detectors have been made with a pitch of 15 or 30&mu;m. We present radiometric performance data and images from our Blue Fairy (320&times;256) and Pelican (640&times;512) detectors, operating at temperatures up to 180K. We demonstrate for both GaSb and GaAs substrates that detector performance can be achieved which is close to "Rule 07", the benchmark for high quality, diffusion limited, Mercury Cadmium Telluride (MCT) devices.
Kinetically controlled peptide bond formation in anhydrous alcohol catalyzed by the industrial protease alcalase (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetically controlled peptide bond formation in anhydrous alcohol catalyzed by the industrial protease alcalaseShui Tein Chen, Shiah Yun Chen, and Kung Tsung WangCite this: J. Org. Chem. 1992, 57, 25, 6960–6965Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jo00051a052https://doi.org/10.1021/jo00051a052research-articleACS PublicationsRequest reuse permissionsArticle Views313Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Imaging Aβ Plaques in Living Transgenic Mice with Multiphoton Microscopy and Methoxy-X04, a Systemically Administered Congo Red Derivative (2002)

The identification of amyloid deposits in living Alzheimer disease (AD) patients is important for both early diagnosis and for monitoring the efficacy of newly developed anti-amyloid therapies. Methoxy-X04 is a derivative of Congo red and Chrysamine-G that contains no acid groups and is therefore smaller and much more lipophilic than Congo red or Chrysamine-G. Methoxy-X04 retains in vitro binding affinity for amyloid beta (Abeta) fibrils (Ki = 26.8 nM) very similar to that of Chrysamine-G (Ki = 25.3 nM). Methoxy-X04 is fluorescent and stains plaques, tangles, and cerebrovascular amyloid in postmortem sections of AD brain with good specificity. Using multiphoton microscopy to obtain high-resolution (1 microm) fluorescent images from the brains of living PSI/APP mice, individual plaques could be distinguished within 30 to 60 min after a single i.v. injection of 5 to 10 mg/kg methoxy-X04. A single i.p. injection of 10 mg/kg methoxy-X04 also produced high contrast images of plaques and cerebrovascular amyloid in PSI/APP mouse brain. Complementary quantitative studies using tracer doses of carbon- 11-labeled methoxy-X04 show that it enters rat brain in amounts that suggest it is a viable candidate as a positron emission tomography (PET) amyloid-imaging agent for in vivo human studies.
Studies on the Synthesis of Insulin from Natural and Synthetic A and B Chains. III. Synthetic Insulins* (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the Synthesis of Insulin from Natural and Synthetic A and B Chains. III. Synthetic Insulins*Panayotis G. Katsoyannis, Anthony C. Trakatellis, Clyde Zalut, Stanley Johnson, Andrew Tometsko, Gerald Schwartz, and James GinosCite this: Biochemistry 1967, 6, 9, 2656–2668Publication Date (Print):September 1, 1967Publication History Published online1 May 2002Published inissue 1 September 1967https://pubs.acs.org/doi/10.1021/bi00861a003https://doi.org/10.1021/bi00861a003research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer (2012)

Bcl-2 targeting by navitoclax shows limited single-agent activity against advanced and recurrent SCLC. Correlative analyses suggest several putative biomarkers of clinical benefit. Preclinical models support that navitoclax may enhance sensitivity of SCLC and other solid tumors to standard cytotoxics. Future studies will focus on combination therapies.
A Low-Cost Storage Server for Movie on Demand Databases (1994)

With recent advances in storage and network technology it is now possible to provide movie on demand (MOD) service, eliminating the inflexibility inherent in todays broadcast cable systems. A MOD server is a computer system that stores movies in compressed digital form and provides support for different portions of compressed movie data to be accessed and transmitted concurrently. In this paper, we present a low-cost storage architecture for a MOD server that relies principally on disks. The high bandwidths of disks in conjunction with a clever strategy for striping movies on them is utilized in order to enable simultaneous access and transmission of &amp;quot;certain&amp;quot; different portions of a movie. We also present a wide range of schemes for implementing VCRlike functions. 1 Introduction The movie on demand (MOD) concept has become exceedingly popular with telecommunications, computer and cable companies. Viewers that subscribe to a MOD service have access to a much wider feature set Permis...
Imprinting Well‐Controlled Nanopores in Organosilicate Dielectric Films: Triethoxysilyl‐Modified Six‐Armed Poly(ϵ‐caprolactone) and Its Chemical Hybridization with an Organosilicate Precursor (2005)

A triethoxysilyl-terminated, six-armed poly(ϵ-caprolactone) porogen is synthesized and the terminal groups are found to significantly reduce the aggregation of the porogen molecules in an organosilicate precursor via their hybridization reaction with the precursor. The porogen molecules successfully imprint nanopores in the organosilicate dielectric thin film (see Figure) through their sacrificial thermal decomposition.
Identification of Metastasis-Associated Receptor Tyrosine Kinases in Non–Small Cell Lung Cancer (2005)

Development of distant metastasis after tumor resection is the leading cause of death in early-stage non-small cell lung cancer (NSCLC). Receptor tyrosine kinases (RTK) are involved in tumorigenesis but only few RTKs have been systematically studied in NSCLC. Here, we provide quantitative real-time reverse transcription-PCR expression data of all RTKs (n=56) in primary tumors of 70 patients with early-stage (I-IIIA) NSCLC. Overall, 33 RTKs were expressed in at least 25% of the patients. Several RTKs were significantly expressed higher in tumors that ultimately metastasized. The hazard risk for metastasis development in stage I/II disease was increased at least 3-fold for tumors with high expression levels of insulin receptor, neurotrophic tyrosine receptor kinase 1, epidermal growth factor receptor, ERBB2, ERBB3, platelet-derived growth factor receptor beta, fibroblast growth factor receptor 1, or leukocyte tyrosine kinase. Relative risks were reduced 3-fold by expression of EPHB6 or DKFZ1. Three members of the epidermal growth factor receptor family were associated with a high risk of metastasis, emphasizing the validity of our data. High ERBB3 expression was significantly associated with decreased survival. Taken together, our genome-wide RTK expression map uncovered the previously unknown value of several RTKs as potential markers for prognosis and metastasis prediction in early-stage NSCLC. The identified RTKs represent promising novel candidates for further functional analyses.
AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling (2016)

The host protein Stimulator of Interferon Genes (STING) has been shown to be essential for recognition of both viral and intracellular bacterial pathogens, but its regulation remains unclear. Previously, we reported that mitochondrial membrane potential regulates STING-dependent IFN-β induction independently of ATP synthesis. Because mitochondrial membrane potential controls calcium homeostasis, and AMP-activated protein kinase (AMPK) is regulated, in part, by intracellular calcium, we postulated that AMPK participates in STING activation; however, its role has yet to be been defined. Addition of an intracellular calcium chelator or an AMPK inhibitor to either mouse macrophages or mouse embryonic fibroblasts (MEFs) suppressed IFN-β and TNF-α induction following stimulation with the STING-dependent ligand 5,6-dimethyl xanthnone-4-acetic acid (DMXAA). These pharmacological findings were corroborated by showing that MEFs lacking AMPK activity also failed to up-regulate IFN-β and TNF-α after treatment with DMXAA or the natural STING ligand cyclic GMP-AMP (cGAMP). As a result, AMPK-deficient MEFs exhibit impaired control of vesicular stomatitis virus (VSV), a virus sensed by STING that can cause an influenza-like illness in humans. This impairment could be overcome by pretreatment of AMPK-deficient MEFs with type I IFN, illustrating that de novo production of IFN-β in response to VSV plays a key role in antiviral defense during infection. Loss of AMPK also led to dephosphorylation at Ser-555 of the known STING regulator, UNC-51-like kinase 1 (ULK1). However, ULK1-deficient cells responded normally to DMXAA, indicating that AMPK promotes STING-dependent signaling independent of ULK1 in mouse cells.
Coded exposure photography (2006)

In a conventional single-exposure photograph, moving objects or moving cameras cause motion blur. The exposure time defines a temporal box filter that smears the moving object across the image by convolution. This box filter destroys important high-frequency spatial details so that deblurring via deconvolution becomes an ill-posed problem.Rather than leaving the shutter open for the entire exposure duration, we "flutter" the camera's shutter open and closed during the chosen exposure time with a binary pseudo-random sequence. The flutter changes the box filter to a broad-band filter that preserves high-frequency spatial details in the blurred image and the corresponding deconvolution becomes a well-posed problem. We demonstrate that manually-specified point spread functions are sufficient for several challenging cases of motion-blur removal including extremely large motions, textured backgrounds and partial occluders.
Forward+: Bringing Deferred Lighting to the Next Level (2012)

This paper presents Forward+, a method of rendering many lights by culling and storing only lights that contribute to the pixel. Forward+ is an extension to traditional forward rendering. Light culling, implemented using the compute capability of the GPU, is added to the pipeline to create lists of lights; that list is passed to the final rendering shader, which can access all information about the lights. Although Forward+ increases workload to the final shader, it theoretically requires less memory traffic compared to compute-based deferred lighting. Furthermore, it removes the major drawback of deferred techniques, which is a restriction of materials and lighting models. Experiments are performed to compare the performance of Forward+ and deferred lighting.
Mobility enhancement and quantum mechanical modeling in Ge/sub x/Si/sub 1-x/ channel MOSFETs from 90 to 300 K (2002)

A peak hole inversion layer mobility of 290 cm/sup 2//V-s has been achieved at room temperature in Ge/sub x/Si/sub 1-x/ buried channel pMOSFETs. The peak mobility rises to 970 cm/sup 2//V-s at 90 K. This corresponds to a 50% enhancement in the effective mobility over Si control devices at room temperature and enhancements of over 100% at 90 K. The mobility of MOS-gated Ge/sub x/Si/sub 1-x/ buried channel transistors can be effectively modeled at room temperature by considering the dependence of the surface scattering on the average separation of carriers from the Si/SiO/sub 2/ interface. The mobility for devices with a 75-AA and a 105-AA Si spacer layer was tested and accurately modeled at room temperature using parameters extracted from a Si control device. At low temperatures ( approximately 90 K) an additional scattering term must be included to better fit the data. It is suggested that this additional term could result from alloy scattering in the Ge/sub x/Si/sub 1-x/ channel.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Agricultural activity recognition with smart-shirt and crop protocol (2015)

Accurate recognition of agricultural activity has a direct bearing on improving farm productivity in terms of achieving crop yield improvements, imparting precision training to farmers wherever needed, and measuring their efforts. Moreover, farm activities are not independent of each other. Cultivation of any crop is associated with a defined pattern of farmer activities called the crop protocol. With an indigenously developed garment for the farmer called smart-shirt, we propose a model for activity classification which has a mean activity prediction accuracy of over 88% for seven classes. The performance of numerous classifiers-SVM, Naive Byes, K-NN, LDA and QDA-is rigorously evaluated and compared for activity prediction. We also propose a model to use the a priori information associated with the crop protocol to recognize the major activity when presented with an unclear evidence of reported activities.