gebhart/patrepeval huggingface dataset:
Deregulated Repression of c-Jun Provides a Potential Link to its Role in Tumorigenesis (2004)

The transcription factor c-Jun cooperates with oncogenic alleles of ras in malignant transformation. Constitutively active Ras causes, via activation of mitogen activated protein kinases, phosphorylation of c-Jun which is essential for subsequent target gene activation and tumorigenesis. Studying the mechanisms controlling c-Jun activity we found that its transcription activation function is actively repressed by a presumably multimeric repressor complex that includes histone deacetylase 3 as a critical subunit. Suppression of c-Jun is relieved by MAP kinase-mediated phosphorylation and/or titration of inhibitor components. The viral tumorigenic counterpart of c-Jun, v-Jun, escapes this inhibition, suggesting deregulated transcriptional activity of c-Jun as a relevant cause for carcinogenesis.
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4)

Restricts

Clonal Expansion of Helper T Cells (2001)

Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansion of proliferating CD4(+) T cells. The regulation of CTLA-4 expression and function ensures that, after approximately 3 cell divisions of expansion, most progeny will succumb to either proliferative arrest or death over the ensuing three cell divisions. The quantitative precision of the counterbalance hinges on the graded, time-independent induction of CTLA-4 expression during the first three cell divisions. In contrast to the limits imposed on unpolarized cells, T helper type 1 (Th1) and Th2 effector progeny may be rescued from proliferative arrest by interleukin (IL)-12 and IL-4 signaling, respectively, allowing appropriately stimulated progeny to proceed to the stage of tissue homing. These results suggest that the cell-autonomous regulation of CTLA-4 induction may be a central checkpoint of clonal expansion of CD4(+) T cells, allowing temporally and spatially restricted growth of progeny to be dictated by the nature of the threat posed to the host.
Development of Three-Dimensional Dental Scanning Apparatus Using Structured Illumination (2017)

We demonstrated a three-dimensional (3D) dental scanning apparatus based on structured illumination. A liquid lens was used for tuning focus and a piezomotor stage was used for the shift of structured light. A simple algorithm, which detects intensity modulation, was used to perform optical sectioning with structured illumination. We reconstructed a 3D point cloud, which represents the 3D coordinates of the digitized surface of a dental gypsum cast by piling up sectioned images. We performed 3D registration of an individual 3D point cloud, which includes alignment and merging the 3D point clouds to exhibit a 3D model of the dental cast.
A Process Variation Tolerant Self-Compensating Sense Amplifier Design (2009)

Lithography related CD variations, fluctuations in dopant density, oxide thickness and parametric variations of devices are identified as major challenges in ITRS. Due to growth in size of embedded SRAMs as well as usage of sense amplifier based signaling techniques, process variation in sense amplifiers lead to significant loss of yield. In this paper, we present a process variation tolerant self-compensating sense amplifier design, using an active compensation circuitry. Results from statistical simulation in a 32 nm process show that the proposed active compensation is highly effective in restoring yield at a level comparable to that of sense amplifiers without significant process variations.
SPIRE spinous process stabilization plate: biomechanical evaluation of a novel technology (2006)

The SPIRE plate effectively stabilized the spine, and the test results compare favorably with other fixation techniques that are more time consuming to perform and have greater inherent risks.
What Determines Buyer‐Seller Relationship Quality? An Investigation from the Buyer's Perspective (2002)

SUMMARY In today's environment, businesses are increasingly dependent on the relationships they have with their suppliers and are demanding that they adhere to high standards. It is increasingly important that buyers have strong relationships with their suppliers to stay ahead of competition. The establishment, development, and maintenance of relationships between exchange partners is crucial to achieving success (Morgan and Hunt 1994). The goal of this research is to further investigate the nature of buyer‐seller relationships from the buyer's perspective and to address the question — what determines the quality of buyer‐seller relationships? Many factors may contribute to the quality of a buyer‐seller relationship. Quality may depend on the nature of the organizations involved, the individuals in the organizations, and the nature of the situation. This study considers two main sets of variables, interpersonal and aspects of the relationship. Interpersonal variables describe the characteristics of individual company representatives, while aspects of the relationship variables describe the situations buyers and sellers face. A unique aspect of this study is that it considers the role both of individuals and of the organizations they represent.
A steroid-binding protein mediates estrogen-dependent inhibition of growth of MCF-7 breast cancer cells. (2000)

We have described two different proteins that mediate MCF-7 cell growth inhibition (1). One is estrogen-dependent and is a heterodimer consisting of a heavy (54 kDa) and light (29 kDa) chain. This protein is distinct from cortisol-binding globulin (CBG), sex hormone-binding protein (SBP or SHBG) and albumin (HSA). It may be fetal steroid binding protein (FSBP). The other is not estrogen dependent, but may be related to the estrogen-dependent protein. Since these are large proteins they must be acting at the level of the plasma membrane, not traditional intracellular estrogen receptors, and inhibit MCF-7 cell growth.
Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α (1999)

A series of isoquinolin-1-ones and quinazolin-4-ones and related derivatives were prepared and evaluated for their ability to inhibit tumor necrosis factor alpha (TNFalpha) production in human peripheral blood monocytes stimulated with bacterial lipopolysaccharide (LPS). In an effort to optimize the TNFalpha inhibitory activity, a homologous series of N-alkanoic acid esters was prepared. Several electrophilic and nucleophilic substitutions were also carried out. Alkanoic acid esters of four carbons were found to be optimum for activity in both the isoquinoline and quinazoline series. Ring substituents such as fluoro, bromo, nitro, acetyl, and aminomethyl on the isoquinoline ring resulted in a significant loss of activity. Likewise, similar groups on the quinazoline ring also reduced inhibitory activity. However, the 6- and 7-aminoquinazoline derivatives, 75 and 76, were potent inhibitors, with IC(50) values in the TNFalpha in vitro assay of approximately 5 microM for each. An in vivo mouse model of pulmonary inflammation was then used to evaluate promising candidate compounds identified in the primary in vitro assay. Compound 75 was selected for further study in this inhalation model, and was found to reduce the level of TNFalpha in brochoalveolar lavage fluid of LPS-treated mice by about 50% that of control mice. Thus, compounds such as 75, which can effectively inhibit proinflammatory cytokines such as TNFalpha in clinically relevant animal models of inflammation and fibrosis, may have potential as new antiinflammatory agents. Finally, a quinazoline derivative suitable to serve as a photoaffinity radiolabeled compound was prepared to help identify the putative cellular target(s) for these TNFalpha inhibitors.
ChemInform Abstract: Synthesis of 7‐Benzylamino‐6‐chloro‐2‐piperazino‐4‐pyrrolidinopteridine and Novel Derivatives Free of Positional Isomers. Potent Inhibitors of cAMP‐Specific Phosphodiesterase and of Malignant Tumor Cell Growth. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Vesicle-Templated Polymer Hollow Spheres (1998)

A cross-linking polymerization of hydrophobic monomers within the surfactant bilayer of vesicles leads to the formation of a quasi-two-dimensional polymer network. Depending on the dimensions of the templating vesicles, polymer hollow spheres can be produced with diameters ranging from several tens of nanometers up to hundreds of micrometers. The hollow sphere morphology of the polymer particles is proved by confocal laser scanning microscopy, scanning electron microscopy, and static and dynamic light scattering. After extraction of the surfactant matrix, the polymer particles contract considerably without loss of their spherical shape. The extend of the contraction depends sensitively on the cross-linking density of the polymer network and shows a similar scaling behavior as branched polymers.
Effect of Sampling Geometry on Elemental Emissions in Laser-Induced Breakdown Spectroscopy (1996)

In laser-induced breakdown spectroscopy (LIBS), a focused laser pulse is used to ablate material from a surface and form a laser plasma that excites the vaporized material. Geometric factors, such as the distance between the sample and the focusing lens and the method of collecting the plasma light, can greatly influence the analytical results. To obtain the best quantitative results, one must consider this geometry. Here we report the results of an investigation of the effect of sampling geometry on LIBS measurements. Diagnostics include time-resolved spectroscopy and temporally and spectrally resolved imaging using an acousto-optic tunable filter (AOTF). Parameters investigated include the type of lens (cylindrical or spherical) used to focus the laser pulse onto the sample, the focal length of the lens (75 or 150 mm), the lens-to-sample distance (LTSD), the angle-of-incidence of the laser pulse onto the sample, and the method used to collect the plasma light (lens or fiber-optic bundle). From these studies, it was found that atomic emission intensities, plasma temperature, and mass of ablated material depend strongly on the LTSD for both types of lenses. For laser pulse energies above the breakdown threshold for air, these quantities exhibit symmetric behavior about an LTSD approximately equal to the back focal length for cylindrical lenses and asymmetric behavior for spherical lenses. For pulse energies below the air breakdown threshold, results obtained for both lenses display symmetric behavior. Detection limits and measurement precision for the elements Be, Cr, Cu, Mn, Pb, and Sr, determined with the use of 14 certified reference soils and stream sediments, were found to be independent of the lens used. Time-resolved images of the laser plasma show that at times &gt;5 μs after plasma formation a cloud of emitting atoms extends significantly beyond the centrally located, visibly white, intense plasma core present at early times (&lt;0.3 μs). It was determined that, by collecting light from the edges of the emitting cloud, one can record spectra using an ungated detector (no time resolution) that resemble closely the spectra obtained from a gated detector providing time-resolved detection. This result has implications in the development of less expensive LIBS detection systems.
Population Pharmacokinetics of Allopurinol in Full-Term Neonates With Perinatal Asphyxia (2006)

In newborn infants, allopurinol is being tested as a free radical scavenger to prevent brain damage caused by reperfusion and oxygenation after perinatal hypoxia and ischemia (birth asphyxia). To develop rational dosing schemes for future studies, knowledge of the pharmacokinetics in this patient group is essential. In the present study, a population pharmacokinetic model was designed and validated for allopurinol in this specific patient group. One-compartment and 2-compartment models were fitted to plasma concentration time data of 24 newborns entered in 2 clinical trials using nonlinear mixed effects modeling. A bootstrap procedure was performed to check the robustness of the model. The data were best described using a 1-compartment model with linear elimination. Estimated pharmacokinetic parameters were volume of the central compartment (V, 0.79 L/kg) and total body clearance (CL, 0.078 L/h/kg), with 42% and 60% interindividual variability, respectively. The median values for these parameters of 1000 bootstrap replicates were very similar (95% confidence intervals were 0.67 to 0.96 and 0.054 to 0.10 for V and CL, respectively), indicating the robustness of the model. A population pharmacokinetic model has been designed and validated which adequately describes the data of 2 clinical studies in critically ill newborn infants. The model will be used to design dosing strategies for future evaluation of the benefits of allopurinol in these patients.
Improving alignment for SMT by reordering and augmenting the training corpus (2009)

We describe the LIU systems for English-German and German-English translation in the WMT09 shared task. We focus on two methods to improve the word alignment: (i) by applying Giza++ in a second phase to a reordered training corpus, where reordering is based on the alignments from the first phase, and (ii) by adding lexical data obtained as high-precision alignments from a different word aligner. These methods were studied in the context of a system that uses compound processing, a morphological sequence model for German, and a part-of-speech sequence model for English. Both methods gave some improvements to translation quality as measured by Bleu and Meteor scores, though not consistently. All systems used both out-of-domain and in-domain data as the mixed corpus had better scores in the baseline configuration.
MicroRNA expression in the adult mouse central nervous system (2008)

MicroRNAs are approximately 22 nucleotide endogenous noncoding RNAs that post-transcriptionally repress expression of protein-coding genes by base-pairing with the 3'-untranslated regions of the target mRNAs. We present here an inventory of miRNA expression profiles from 13 neuroanatomically distinct areas of the adult mouse central nervous system (CNS). Microarray profiling in combination with real-time RT-PCR and LNA (locked nucleic acid)-based in situ hybridization uncovered 44 miRNAs displaying more than threefold enrichment in the spinal cord, cerebellum, medulla oblongata, pons, hypothalamus, hippocampus, neocortex, olfactory bulb, eye, and pituitary gland. These findings suggest that a large number of mouse CNS-expressed miRNAs may be associated with specific functions within these regions. Notably, more than 50% of the identified mouse CNS-enriched miRNAs showed different expression patterns compared to those reported in zebrafish, although the mature miRNA sequences are nearly 100% conserved between the two vertebrate species. The inventory of miRNA profiles in the adult mouse CNS presented here provides an important step toward further elucidation of miRNA function and miRNA-related gene regulatory networks in the mammalian central nervous system.
ChemInform Abstract: STUDIES OF NUCLEOSIDES AND NUCLEOTIDES. LXXIV. PURINE CYCLONUCLEOSIDES. 34. 4. A NEW METHOD FOR THE SYNTHESIS OF 2′‐SUBSTITUTED 2′‐DEOXYADENOSINES (1978)

Abstract Das Acetylierungsprodukt (Ib) des Cyclonuc1eosids(Ia) wird über die Stufen (II), (IIIa) und (IIIb) zum mesylierten Nucleosid (IIIc) umgesetzt, dessen Reaktion mit Na‐azid das Azidoderivat (IV) liefert.
XDS (2010)

The usage and control of recent modifications of the program package XDS for the processing of rotation images are described in the context of previous versions. New features include automatic determination of spot size and reflecting range and recognition and assignment of crystal symmetry. Moreover, the limitations of earlier package versions on the number of correction/scaling factors and the representation of pixel contents have been removed. Large program parts have been restructured for parallel processing so that the quality and completeness of collected data can be assessed soon after measurement.
Argumentation Mining (2016)

Argumentation mining aims at automatically extracting structured arguments from unstructured textual documents. It has recently become a hot topic also due to its potential in processing information originating from the Web, and in particular from social media, in innovative ways. Recent advances in machine learning methods promise to enable breakthrough applications to social and economic sciences, policy making, and information technology: something that only a few years ago was unthinkable. In this survey article, we introduce argumentation models and methods, review existing systems and applications, and discuss challenges and perspectives of this exciting new research area.
Synthesis of Macrocyclic Urea Kinase Inhibitors (2007)

An efficient and convergent route was developed for the synthesis of a novel class of urea-based macrocyclic kinase inhibitors. The synthesis is featured with an efficient urea formation by using a key carbamate intermediate and with a smooth ring-closure olefin metathesis. Furthermore, the hydrogenations of the resulting olefins were investigated in this complex macrocyclic ring system.
Superhydrophobic and Low Light Reflectivity Silicon Surfaces Fabricated by Hierarchical Etching (2008)

Silicon is employed in a variety of electronic and optical devices such as integrated circuits, photovoltaics, sensors, and detectors. In this paper, Au-assisted etching of silicon has been used to prepare superhydrophobic surfaces that may add unique properties to such devices. Surfaces were characterized by contact angle and contact angle hysteresis. Superhydrophobic surfaces with reduced hysteresis were prepared by Au-assisted etching of pyramid-structured silicon surfaces to generate hierarchical surfaces. Consideration of the Laplace pressure on hydrophobized hierarchical surfaces gives insight into the manner by which contact is established at the liquid/composite surface interface. Light reflectivity from the etched surfaces was also investigated to assess application of these structures to photovoltaic devices.
Molecular characterization and expression analysis of a highly conserved ricemago nashi1homolog (2001)

Mago Nashi, a protein initially shown to be essential in the development of the Drosophila oocyte, is highly conserved among species and shows no homology to any other known cellular proteins. Here we report the nucleotide sequence of a cDNA and a partial gene that encode rice Mago Nashi protein homologs. In addition, we present the tissue-specific expression pattern of mago nashi at the level of RNA and protein. The rice Mago Nashi protein shares at least 73% amino acid identity with all known animal homologs. Genomic DNA gel blot analysis indicates that two copies of the mago nashi gene exist in the rice genome, one of which has identical intron positions to those found in an Arabidopsis homolog. mago nashi is expressed in root, leaf and developing seed tissue as determined by RNA and protein gel blot analysis. Evidence from Drosophila, Caenorhabditis elegans and human studies of Mago Nashi suggests that a major function of this protein is its involvement in RNA localization. The highly conserved amino acid sequence of all Mago Nashi protein homologs across kingdoms suggests that the plant version of this protein may similarly be involved in RNA localization.
Cross-Linked Normal Hexagonal and Bicontinuous Cubic Assemblies via Polymerizable Gemini Amphiphiles (2003)

The synthesis and lyotropic liquid-crystalline (LLC) phase behavior of a homologous series of intrinsically cross-linkable gemini surfactants are described. These novel bis(alkyl-1,3-diene)-based phosphonium gemini amphiphiles exhibit "normal" hexagonal (H(I)), Type I bicontinuous cubic (Q(I)), and lamellar (L(alpha)) phases in water, and can be photocross-linked with retention of phase architecture in each case. On the basis of their locations on the phase diagram, their powder X-ray diffraction profiles, and the physical properties of the cross-linked materials, the Q(I) phases formed by these gemini monomers are consistent with four possible bicontinuous cubic architectures with P or I space group symmetry that have been identified previously for small molecule amphiphiles. The extent of polymerization (i.e., the degree of diene conversion) achieved in the LLC phases was determined to be in the 23% to 71% range using UV-vis spectrometry, which is more than sufficient to extensively stabilize the systems. The resulting cross-linked H(I), L(alpha), and Q(I) phases are stable up to 300 degrees C in air. To our knowledge, these reactive amphiphiles constitute the first example of a polymerizable gemini surfactant, and the first example of a cross-linkable amphiphile system that can be polymerized in both the H(I) and a Q(I) mesophase with retention of phase microstructure.
Experimental arthritis in CC chemokine receptor 2–null mice closely mimics severe human rheumatoid arthritis (2004)

The prevailing paradigm is that in human rheumatoid arthritis (RA), the accumulation of monocytes and T cells in the joint, mediated in part by such CC chemokine receptors (CCRs) as CCR2 and CCR5, respectively, plays a central role in disease pathogenesis. To further validate this paradigm, we conducted proof-of-principle studies and tested the hypothesis that gene inactivation of Ccr2 or Ccr5 will ameliorate experimental RA. Contrary to our expectations, we found that in two well-established murine models of experimental RA, CCR2 expression in the hematopoietic cell compartment served as a negative regulator of autoantibody production as well as arthritic disease onset, severity, and resolution. In contrast, the RA phenotype in Ccr5-null mice was similar to that of WT mice. Remarkably, the collagen-induced arthritis phenotype of Ccr2-/- mice mimicked closely that of severe human RA, including production of rheumatoid factor, enhanced T cell production, and monocyte/macrophage accumulation in the joints. Our findings demonstrate an essential protective role of CCR2 expression in RA, indicate the existence of alternative receptors responsible for monocyte/macrophage accumulation to inflamed joints, and emphasize the need to clarify carefully the complex effects of the chemokine system in RA before they can be considered as therapeutic targets.
A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni. (1990)

We present evidence that a subset of mRNAs in the human parasitic trematode Schistosoma mansoni contain an identical 36-nucleotide spliced leader (SL) sequence at their 5' termini. The SL is derived from a 90-nucleotide nonpolyadenylylated RNA (SL RNA), presumably by trans-splicing. Neither the SL nor the SL RNA share significant sequence identity with previously described trans-spliced leaders and SL RNAs in trypanosomatid protozoans or nematodes. However, several features, such as predicted secondary structure, trimethylguanosine cap, and potential Sm binding site, suggest similarities among SL RNAs in widely divergent organisms. Our evidence also indicates that the exon 3 acceptor site of the 3-hydroxy-3-methylglutaryl-CoA reductase gene can be spliced either to the SL by trans-splicing or to an upstream exon, 2, by cis-splicing. The presence of a SL sequence in S. mansoni, a member of the phylum Platyhelminthes, suggests that transplicing may be a common feature of other lower invertebrates.