gebhart/patrepeval huggingface dataset:
User-Specific Hand Modeling from Monocular Depth Sequences (2014)

This paper presents a method for acquiring dense nonrigid shape and deformation from a single monocular depth sensor. We focus on modeling the human hand, and assume that a single rough template model is available. We combine and extend existing work on model-based tracking, subdivision surface fitting, and mesh deformation to acquire detailed hand models from as few as 15 frames of depth data. We propose an objective that measures the error of fit between each sampled data point and a continuous model surface defined by a rigged control mesh, and uses as-rigid-as-possible (ARAP) regularizers to cleanly separate the model and template geometries. A key contribution is our use of a smooth model based on subdivision surfaces that allows simultaneous optimization over both correspondences and model parameters. This avoids the use of iterated closest point (ICP) algorithms which often lead to slow convergence. Automatic initialization is obtained using a regression forest trained to infer approximate correspondences. Experiments show that the resulting meshes model the user's hand shape more accurately than just adapting the shape parameters of the skeleton, and that the retargeted skeleton accurately models the user's articulations. We investigate the effect of various modeling choices, and show the benefits of using subdivision surfaces and ARAP regularization.
Coherent Spin Control at the Quantum Level in an Ensemble-Based Optical Memory (2015)

Long-lived quantum memories are essential components of a long-standing goal of remote distribution of entanglement in quantum networks. These can be realized by storing the quantum states of light as single-spin excitations in atomic ensembles. However, spin states are often subjected to different dephasing processes that limit the storage time, which in principle could be overcome using spin-echo techniques. Theoretical studies suggest this to be challenging due to unavoidable spontaneous emission noise in ensemble-based quantum memories. Here, we demonstrate spin-echo manipulation of a mean spin excitation of 1 in a large solid-state ensemble, generated through storage of a weak optical pulse. After a storage time of about 1 ms we optically read-out the spin excitation with a high signal-to-noise ratio. Our results pave the way for long-duration optical quantum storage using spin-echo techniques for any ensemble-based memory.
Molecular oxygen and carbon monoxide binding to "jellyfish" type iron(II) porphyrins (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular oxygen and carbon monoxide binding to "jellyfish" type iron(II) porphyrinsYoshio Uemori and Eishin KyunoCite this: Inorg. Chem. 1989, 28, 9, 1690–1694Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ic00308a019https://doi.org/10.1021/ic00308a019research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene. (1988)

We investigated the cis-acting sequences that function in the B-cell-specific and interferon-gamma-inducible expression of the HLA-DR alpha gene, a human class II major histocompatibility complex gene. The effects of 5' deletions on the activity of the DR alpha promoter and the influence of upstream DR alpha promoter elements on the activity of the herpes simplex virus thymidine kinase promoter were examined by a transient transfection assay in human B-, T-, and fibroblast cell lines. We show that the DR alpha gene is regulated by positive and negative cis-acting sequences between positions -1300 and +31 from the site of initiation of transcription. We also demonstrate that the DR alpha promoter sequences from positions -116 to -92 and from -136 to -80 are the minimal sequences required for conferring B-cell specificity and interferon-gamma inducibility upon the Herpes simplex virus thymidine kinase promoter, respectively.
Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients (2008)

Plasma gelsolin may be a valuable marker for severe sepsis. Recovery of depleted plasma gelsolin levels correlated with clinical improvement. The prognostic role of plasma gelsolin in critical illness requires further investigation in a large cohort.
IL-33: A Potential Therapeutic Target in Autoimmune Diseases (2012)

Interleukin 33 (IL-33) is a newly described member of the IL-1 superfamily of cytokines. Through activation of the ST2 receptor, which is widely expressed particularly by helper T 2 cells and mast cells, IL-33 is involved in T-cell-mediated immune responses. Many previous studies have demonstrated that IL-33 may have a pleiotropic function in different diseases, and it could represent a novel target for the treatment of a range of diseases. Recent works have explored the role of IL-33 in chronic autoimmune diseases, such as systemic sclerosis, inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus. These results indicate that IL-33 may contribute to the pathogenesis of chronic autoimmune diseases. Hence, in this review, we discuss the biological features of IL-33 and summarize recent advances on the role of IL-33 in the pathogenesis and treatment of autoimmune diseases.
Ghana, Lesotho, and South Africa: Regional Expansion of Water Supply in Rural Areas (2004)

Water, sanitation, and hygiene are essential for achieving all the Millennium Development Goals (MDGs) and hence for contributing to poverty eradication globally. This case study contributes to the learning process on scaling up poverty reduction by describing and analyzing three programs in rural water and sanitation in Africa: the national rural water sector reform in Ghana, the national water and sanitation program in South Africa, and the national sanitation program in Lesotho. These national programs have made significant progress towards poverty elimination through improved water and sanitation. Although they are all different, there are several general conclusions that can validly be drawn from them: Top-level political commitment to water and sanitation, sustained consistently over a long time period, is critically important to the success of national sector programs. Clear legislation is necessary to give guidance and confidence to all the agencies working in the sector. Devolution of authority from national to local government and communities improves the accountability of water and sanitation programs. The involvement of a wide range of local institutions-social, economic, civil society, and media-empowers communities and stimulates development at the local scale. The sensitive, flexible, and country-specific support of external agencies can add significant momentum to progress in the water and sanitation sector.
The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells. (1989)

Immunoprecipitation and Western immunoblotting studies were undertaken using purified high-affinity antibodies against a synthetic peptide corresponding to a portion of the deduced retinoblastoma (RB) protein. On SDS-PAGE, normal human cells showed an RB protein pattern consisting of a lower sharp band with a Mr of 110 kD and a more variable region above this band with a Mr ranging from 110 kD to 116 kD. The 110 kD band represents the unphosphorylated Rb protein whereas the broader, less well defined region is the phosphorylated RB protein in which molecular mass heterogenicity results from varying amount of phosphorylation. This pattern repeats once at a lower Mr in which a 98 kD band and 98-104 kD variable region can be visualized. This latter conformation seems to represent the unphosphorylated and phosphorylated RB protein translated from the second AUG codon of the RB mRNA. Cellular RB mRNA extracted from normal fibroblasts was translated in vitro reinforcing the usage of this second start codon. A higher ratio of phosphorylated to unphosphorylated Rb protein was seen in cells growing in log phase compared to those arrested in G1 phase. Our present studies also detected two candidates for RB-associated cellular proteins with a Mr of 124 kD and 55 kD respectively. In addition, shortened versions of RB-isoantigenic proteins were found in retinoblastoma and osteosarcoma cell lines.
Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes (1993)

We have synthesized three bisacridine intercalators containing a galactose residue(s) to target DNA to cell surface receptors for use in gene-delivery systems. Each of the bisacridines could intercalate into DNA with micromolar dissociation constants. Bisacridines containing a single galactose on either a three- or six-carbon spacer from the secondary amine of spermidine-bisacridine could mediate binding of DNA to the soluble galactose receptor Ricinus communis lectin (RCA I), but not to the asialoglycoprotein receptor on primary hepatocytes. A trigalactosyl dilysyl bisacridine [(Gal-6)3Lys2-bA] compound could mediate the binding of DNA to both the ricin lectin and to primary hepatocytes. Binding of the (Gal-6)3Lys2-bA-DNA to the hepatocytes could be blocked by asialoorosomucoid. On the basis of luciferase expression, (Gal-6)3Lys2-bA did not induce transfection of the hepatocytes when attached to the pCLUC4 plasmid encoding the firefly luciferase gene.
Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine (1996)

It is proposed here that the delayed cytotoxicity of thioguanine involves the postreplicative DNA mismatch repair system. After incorporation into DNA, the thioguanine is chemically methylated by S-adenosylmethionine to form S6-methylthioguanine. During DNA replication, the S6-methylthioguanine directs incorporation of either thymine or cytosine into the growing DNA strand, and the resultant S6-methylthioguanine-thymine pairs are recognized by the postreplicative mismatch repair system. Azathioprine, an immunosuppressant used in organ transplantation, is partly converted to thioguanine. Because the carcinogenicity of N-nitrosamines depends on formation of O6-alkylguanine in DNA, the formation of the analog S6-methylthioguanine during azathioprine treatment may partly explain the high incidence of cancer after transplantation.
[Clinico-pharmacological case (2). Bradycardia and ventricular tachycardia of the torsades de pointes type as a side effect of vasopressin: 3 case reports]. (1996)

We present three patients with ornipressin-induced bradycardia, one of which developed also ventricular tachycardia of the torsade de pointes type. All three patients were treated with this vasopressin derivative because of bleeding esophageal varices due to portal hypertension in liver cirrhosis. Bradycardia ceased after discontinuing ornipressin therapy. One patient was treated successfully with atropine, one with isoprenalin and magnesium (he had to be defibrillated); the third patient recovered after cessation of ornipressin administration. Bradycardia is a known but rarely reported side effect of vasopressin and its derivatives. Animal studies suggest that this effect is due to its cardiodepressive action and also to a vagus-mediated reflex following vasopressin-induced increase in blood pressure. When injected directly into the ventricles of the brain, vesopressin leads to a decrease of the heart rate without affecting blood pressure; however, it remains unclear whether this mechanism is responsible for bradycardia after intravenous administration. Careful monitoring is essential during the treatment with vasopressin and its derivatives.
Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide (1998)

Sixteen metastatic breast cancer patients were immunized with a low dose (5 micrograms) of a 16 amino acid MUC1 peptide (GVTSAPDTRPAPGSTA) conjugated to KLH (BP16-KLH) plus DETOX adjuvant and evaluated for antibody titers against MUC1 peptide and KLH and for cytotoxic lymphocyte (CTL) activity using class 1 HLA-matched MUC1-positive tumor targets. All patients generated strong anti-KLH IgG responses. Only 3 patients developed an anti-MUC1 IgG response, which was weak in magnitude. As it is controversial whether human cancer patients generate class-1-restricted CTL against MUC1, we examined anti-MUC1 CTL activity of PBLs following 4 immunizations with BP16-KLH. The generation of MUC1-specific CTLs required only a 6-day in vitro stimulation of patients' T-cells with synthetic MUC1-peptide-pulsed autologous APCs. The assay for CTL activity was a 4 hour 51Cr release from labeled adenocarcinoma target cells. Eleven of the 16 immunized patients were tested for CTL activity using class-1-matched adenocarcinoma target cell lines. Evidence for class-1-restricted killing of MUC1-expressing tumor cell lines was obtained in 7 of these 11 patients.
The Relationship between Serum Human Immunodeficiency Virus Type 1 (HIV‐1) RNA Level, CD4 Lymphocyte Percent, and Long‐Term Mortality Risk in HIV‐1—Infected Children (1997)

Association of human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 cell percent, and mortality was examined in stored sera from 254 infected children in an intravenous immunoglobulin infection prophylaxis trial. Ninety-two children (36.2%) died (41 during the study, 51 during long-term follow-up). The geometric mean baseline HIV-1 RNA level was 104,626 copies/mL, and the mean CD4 cell percent was 25%. Relative risk of death (RR) was 2.1 if the baseline RNA level was >100,000 copies/mL (95% confidence interval [CI], 1.4-3.0) and was 3.0 if the baseline CD4 cell percent was <15% (95% CI, 2.2-4.0). If RNA levels increased after baseline, the RR was 1.8 (95% CI, 1.3-2.6), and if the CD4 cell percent dropped to <15%, the RR was 2.8 (95% CI, 1.6-4.9). In a multivariate model, both baseline RNA level and CD4 cell percent were independently associated with mortality risk. In a time-dependent model, the RR per log10 increase in HIV-1 RNA copy numbers was 2.8 (95% CI, 2.1-3.6) and per 5 percentage point decrement in CD4 cell percent was 1.3 (95% CI, 1.2-1.5). Both variables should be considered for in decision-making regarding therapy and evaluation of antiretroviral response.
Heterogeneity of growth potential of adult rat hepatocytes in vitro (2000)

Nearly pure populations of small hepatocytes (SHs), parenchymal hepatocytes (PHs), and nonparenchymal cells (NPCs) were prepared from the adult rat, and cocultures of hepatocytes and NPCs were reconstituted from them first to obtain the direct evidence that NPCs promote the growth of hepatocytes and second to compare the growth potential between SHs and PHs. SHs and PHs underwent multiple divisions when cocultured with NPCs, whereas neither SHs nor PHs formed colonies at 10 days when cultured alone. Stellate cells in the NPCs were shown to be responsible for this growth promotion. SHs showed a higher growth capacity than PHs. To clearly show the relationship between the growth potential and the size of hepatocytes, SHs and PHs were further fractionated by a fluorescence-activated cell sorter, because the size distribution of SHs and PHs was half overlapped. SHs produced 2 cell populations, SH-R2 and SH-R3. The former showed a greater extent of granularity and autofluorescence than the latter. In contrast, PHs produced only 1 population (PH-R2), which corresponded to the SH-R2. The size of hepatocytes of SH-R3 was smaller (17.1 +/- 0.2 microm) than those of SH-R2 (22.6 +/- 0.5 microm) and PH-R2 (24.1 +/- 0.1 microm) and there was not a significant overlap in the size distribution between the 2 groups. The hepatocytes of SH-R3 were highly replicative and 4 or 5 times higher in their growth potential than those of SH-R2 and PH-R2. We concluded that the growth potential of hepatocytes is heterogeneous and is correlated with their size and the extent of their granularity and autofluorescence.
Dual Calcium Ion Regulation of Calcineurin by Calmodulin and Calcineurin B (1994)

The dependence of calcineurin on Ca2+ for activity is the result of the concerted action of calmodulin, which increases the turnover rate of the enzyme and modulates its response to Ca2+ transients, and of calcineurin B, which decreases the Km of the enzyme for its substrate. The calmodulin-stimulated protein phosphatase calcineurin is under the control of two functionally distinct, but structurally similar, Ca(2+)-regulated proteins, calmodulin and calcineurin B. The Ca(2+)-dependent activation of calcineurin by calmodulin is highly cooperative (Hill coefficient of 2.8-3), and the concentration of Ca2+ needed for half-maximum activation decreases from 1.3 to 0.6 microM when the concentration of calmodulin is increased from 0.03 to 20 microM. Conversely, the affinity of calmodulin for Ca2+ is increased by more than 2 orders of magnitude in the presence of a peptide corresponding to the calmodulin-binding domain of calcineurin A. Calmodulin increases the Vmax without changing the Km value of the enzyme. Unlike calmodulin, calcineurin B interacts with calcineurin A in the presence of EGTA, and Ca2+ binding to calcineurin B stimulates native calcineurin up to only 10% of the maximum activity achieved with calmodulin. The Ca(2+)-dependent activation of a proteolyzed derivative of calcineurin, calcineurin-45, which lacks the regulatory domain, was used to study the role of calcineurin B. Removal of the regulatory domain increases the Vmax of calcineurin, as does binding of calmodulin, but it also increases the affinity of calcineurin for Ca2+. Ca2+ binding to calcineurin B decreases the Km value of calcineurin without changing its Vmax.(ABSTRACT TRUNCATED AT 250 WORDS)
TOWARD DEVELOPMENT OF IMAGING MODALITIES FOR ISLETS AFTER TRANSPLANTATION: INSIGHTS FROM THE NATIONAL INSTITUTES OF HEALTH WORKSHOP ON BETA CELL IMAGING (2004)

The consensus among investigators at the imaging workshop was that an accurate and reproducible in vivo measure of functional islet mass is critically needed to further the strides that have been made in both islet transplantation and diabetes research as a whole. Such measures would potentially allow the assessment of islet engraftment and the early recognition of graft loss, leading to greater improvements in islet graft survival and function.
Atypical Protein Kinase Cι Is an Oncogene in Human Non–Small Cell Lung Cancer (2005)

Protein kinase C (PKC) isozymes have long been implicated in carcinogenesis. However, little is known about the functional significance of these enzymes in human cancer. We recently showed that the atypical PKC (aPKC) isozyme PKCiota is overexpressed in human non-small cell lung cancer (NSCLC) cells and that PKCiota plays a critical role in the transformed growth of the human lung adenocarcinoma A549 cell line in vitro and tumorigenicity in vivo. Here we provide compelling evidence that PKCiota is an oncogene in NSCLC based on the following criteria: (a) aPKCiota is overexpressed in the vast majority of primary NSCLC tumors; (b) tumor PKCiota expression levels predict poor survival in patients with NSCLC; (c) the PKCiota gene is frequently amplified in established NSCLC cell lines and primary NSCLC tumors; (d) gene amplification drives PKCiota expression in NSCLC cell lines and primary NSCLC tumors; and (e) disruption of PKCiota signaling with a dominant negative PKCiota allele blocks the transformed growth of human NSCLC cells harboring PKCiota gene amplification. Taken together, our data provide conclusive evidence that PKCiota is required for the transformed growth of NSCLC cells and that the PKCiota gene is a target for tumor-specific genetic alteration by amplification. Interestingly, PKCiota expression predicts poor survival in NSCLC patients independent of tumor stage. Therefore, PKCiota expression profiling may be useful in identifying early-stage NSCLC patients at elevated risk of relapse. Our functional data indicate that PKCiota is an attractive target for development of novel, mechanism-based therapeutics to treat NSCLC.
Feedforward Interference Cancellation in Radio Receiver Front-Ends (2007)

An interference cancellation technique is described for improving the dynamic range of receivers. A feedforward approach is used to attenuate large interferers before the down-conversion mixer in a receiver. This is accomplished with no measurable impact on the in-band noise performance. Techniques to cancel interference within a narrowband and also in multiple bands are described. Simulation results and measurements from a discrete prototype system are used to validate the approach.
Development of Freeway Travel Time Forecasting Models by Integrating Different Sources of Traffic Data (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Artificial neural network (ANN) techniques are applied to build a travel time estimation model. The model exhibits a functional relation between real-time traffic data as the input variables and the actual bus travel time as the output variable. A great quantity of traffic data is collected from intercity buses equipped with global positioning systems, vehicle detectors along the roadway, and the incident database. For model development, data from neighboring sections and time intervals are considered to present the time–space relation of traffic. To account for the various methods of specifying freeway sections, four criteria are employed to partition the freeway into comparable units. These are based on interchanges, similar distances, travel times, and geometry. The southern part of the number one national freeway in Taiwan is selected as the case study. In most sections of the four partitions, the mean absolute percentage errors (MAPEs) of the predicted travel time are under 20%, which indicates a good forecasting effect. For practical use purposes, the path travel time is obtained from the section models with a dynamic forecast concept. Through the validation process, the MAPEs of the travel times at each O–D path (from Original point to Destination point) are known to be mostly under 20%. These results suggest that this dynamic forecasting approach is practical and reliable for modeling travel time characteristics. </para>