gebhart/patrepeval huggingface dataset:
STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN® II (1987)

Abstract Using three methods to attempt to identify the presence of ester‐linked porphyrins in Photofrin® II, lithium aluminum hydride reduction, basic hydrolysis and proton NMR. it can be concluded that 40‐50% of such linkages are present. The majority of the remaining material is cleaved by acid hydrolysis, which is consistent with the ether structure proposed earlier. earlier.
LexA protein of Escherichia coli represses expression of the Tn5 transposase gene (1991)

The LexA protein of Escherichia coli represses expression of a variety of genes that, by definition, constitute the SOS regulon. Genetic evidence suggests that Tn5 transposition is also regulated by the product of the lexA gene (C.-T. Kuan, S.-K. Liu, and I. Tessman, Genetics 128:45-57, 1991). We now show that the LexA protein represses expression of the tnp gene, located in the IS50R component of Tn5, which encodes a transposase, and that LexA does not repress expression of the IS50R inh gene, which encodes an inhibitor of transposition. Elimination of LexA resulted in increased expression of the tnp gene by a factor of 2.7 +/- 0.4, as indicated by the activity of a lacZ gene fused to the tnp gene. LexA protein retarded the electrophoretic movement of a 101-bp segment of IS50R DNA that contained a putative LexA protein-binding site in the tnp promoter; the interaction between the LexA repressor and the promoter region of the tnp gene appears to be relatively weak. These features show that the IS50R tnp gene is a member of the SOS regulon.
Solving the starting problem (2006)

Run-time conflicts can affect even the most rigorously tested software systems. A reliance on execution-based testing makes it prohibitively costly to test every possible interaction among potentially thousands of programs with complex configurations. In order to reduce configuration problems, detect developer errors, and reduce developer effort, we have created a new first class operating system abstraction, the application abstraction, which enables both online and offline reasoning about programs and their configuration requirements.We have implemented a subset of the application abstraction for device drivers in the Singularity operating system. Programmers use the application abstraction by placing declarative statements about hardware and communication requirements within their code. Our design enables Singularity to learn the input/output and interprocess communication requirements of drivers without executing driver code. By reasoning about this information within the domain of Singularity's strong software isolation architecture, the installer can execute a subset the system's resource management algorithm at install time to verify that a new driver will not conflict with existing software. This abstract representation also allows the system to run the full algorithm at driver start time to ensure that there are never resource conflicts between executing drivers, and that drivers never use undeclared resources.
Mental deficiency, alterations in performance, and CNS abnormalities in Overgrowth syndromes (2003)

Mental deficiency, alterations in performance, and central nervous system (CNS) abnormalities are discussed in the following overgrowth syndromes: Sotos syndrome, Weaver syndrome, Proteus syndrome, neurofibromatosis type 1, fragile X syndrome, syndromes with neonatal hypoglycemia, Simpson-Golabi-Behmel syndrome, hemihyperplasia, Sturge-Weber syndrome, Bannayan-Riley-Ruvalcaba/Cowden syndrome, macrocephaly-autism syndrome, PEHO syndrome, chromosomal syndromes, and other miscellaneous syndromes.
Inhibition of Prostate Cancer Cell Growth by Human Secreted PDZ Domain-Containing Protein 2, a Potential Autocrine Prostate Tumor Suppressor (2006)

A possible role of the PDZ domain-containing protein 2 (PDZD2) in prostate tumorigenesis has been suggested. Besides, PDZD2 is posttranslationally cleaved by a caspase-dependent mechanism to form a secreted PDZ domain-containing protein 2 (sPDZD2) with unknown functions in humans. In this study, we demonstrate the endogenous expression of PDZD2 and secretion of sPDZD2 in cancerous DU145, PC-3, 22Rv1, LNCaP, and immortalized RWPE-1 prostate epithelial cells. Inhibition of endogenous sPDZD2 production and secretion by DU145, PC-3, 22Rv1, and RWPE-1 cells via the caspase-3 inhibitor Z-DEVD-FMK resulted in increased cell proliferation, which was abrogated by treatment with exogenous recombinant sPDZD2. Whereas sPDZD2-induced antiproliferation in DU145, PC-3, and 22Rv1 cells, it induced apoptosis in LNCaP cells. The data suggest that endogenous sPDZD2, produced by caspase-3-mediated cleavage from PDZD2, may function as a novel autocrine growth suppressor for human prostate cancer cells. The antiproliferative effect of sPDZD2 was apparently mediated through slowing the entry of DU145, PC-3, and 22Rv1 cells into the S phase of the cell cycle. In DU145 cells, this can be attributed to stimulated p53 and p21(CIP1/WAF1) expression by sPDZD2. On the other hand, the apoptotic effect of sPDZD2 on LNCaP cells was apparently mediated via p53-independent Bad stimulation. Together our results indicate the presence of p53-dependent and p53-independent PDZD2/sPDZD2 autocrine growth suppressive signaling pathways in human prostate cancer cells and suggest a novel therapeutic approach of harnessing the latent tumor-suppressive potential of an endogenous autocrine signaling protein like sPDZD2 to inhibit prostate cancer growth.
Gamma radiation effects in Yb-doped optical fiber (2007)

Abstract not provided.
The Pathogenesis of Podagra (1977)

Precipitation of crystals from solution is a relatively simple phenomenon that should be explained by changes in concentration, temperature, pH, or other local factors. Which of these factors determines the preferential precipitation of urate crystals at the base of the big toe? Podagra correlates with degenerative joint disease of the toe, often follows abuse of the feet, and classically occurs in the middle of the night. These characteristics suggest that crystals may form in resolving synovial effusions. The urate concentration must transiently rise in such an effusion because water will leave the joint space twice as fast as urate. If the local concentration surpasses the solubility of urate, crystals will form that may than induce acute podagra.
Coronary Heart Disease Prediction From Lipoprotein Cholesterol Levels, Triglycerides, Lipoprotein(a), Apolipoproteins A-I and B, and HDL Density Subfractions (2001)

Optimal LDL-C values are <100 mg/dL in both women and men. LDL-C, HDL-C, TG, and Lp(a), without additional apolipoproteins or lipid subfractions, provide substantial CHD prediction, with much higher RR in women than men.
Nanoscale CMOS circuit leakage power reduction by double-gate device (2004)

Leakage power for extremely scaled (Leff = 25 nm) double-gate devices is examined. Numerical two-dimensional simulation results for double-gate CMOS device/circuit power are presented from physics principle, identifying that double-gate technology is an ideal candidate for low-power applications. Unique double-gate device features resulting from gate-gate coupling are discussed and effectively exploited for optimal low-leakage device design. Design trade-offs for double-gate CMOS power and performance are suggested for low-power and high-performance applications. Total power consumptions of static and dynamic circuits and latches for double-gate device are analyzed considering state dependency, showing that leakage current is reduced by a factor of over 10X, compared with conventional bulk-Si counterpart.
Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America (2009)

Evidence-based guidelines for managing patients with intra-abdominal infection were prepared by an Expert Panel of the Surgical Infection Society and the Infectious Diseases Society of America. These updated guidelines replace those previously published in 2002 and 2003. The guidelines are intended for treating patients who either have these infections or may be at risk for them. New information, based on publications from the period 2003-2008, is incorporated into this guideline document. The panel has also added recommendations for managing intra-abdominal infection in children, particularly where such management differs from that of adults; for appendicitis in patients of all ages; and for necrotizing enterocolitis in neonates.
Endogenous hydrogen sulfide and the cardiovascular system-what's the smell all about? (2006)

Gasotransmitter research is relevant to the pathophysiology of a number of cardiovascular disease processes.
Review of 20 years of range sensor development (2004)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Relationship between Napping and Melatonin in the Blind (1997)

Daytime sleepiness is a common complaint in blind subjects. Abnormally timed melatonin has been invoked as a possible cause of both daytime sleepiness and nighttime awakening. In free-running blind individuals, there is an opportunity to assess the relationship between endogenous melatonin rhythms and subjective sleepiness and naps. The aim of this study was to characterize melatonin rhythms and simultaneously to evaluate subjective napping. A total of 15 subjects with no conscious light perception (NPL) were studied for 1 month. Prior to the study, sleep disorders were assessed using the Pittsburgh Sleep Quality Index. Cosinor and regression analysis revealed that 9 of the 15 NPL subjects had free-running 6-sulphatoxymelatonin (aMT6s) rhythms (period [tau] range = 24.34 to 24.79 h), 3 were entrained with an abnormal phase, and 3 were normally entrained. Most of the subjects (13 of 15) had daytime naps; the 2 individuals who did not made conscious efforts not to do so. Subjects with abnormal aMT6s rhythms had more naps of a longer duration than did those with normal rhythms. Free-running nap rhythms occurred only in subjects with free-running aMT6s rhythms. The 2 abnormally entrained subjects who napped did so at times that coincided with high levels of aMT6s (mean aMT6s acrophase [phi] +/- SD = 14.30 +/- 1.08 h, 20.30 +/- 0.62 h; mean nap time +/- SD = 14.01 +/- 3.60 h, 18.23 +/- 3.20 h, respectively). Regardless of aMT6s rhythm abnormality, significantly more naps occurred with a 4-h period before and after the estimated aMT6s acrophase. In 4 free-running subjects, aMT6s acrophase (phi) passed through an entire 24-h period. When aMT6s was in a normal phase position (24:00 to 06:00 h), night-sleep duration tended to increase with a significant reduction in the number and duration of naps. Sleep onset and offset times tended to advance and delay as the aMT6s rhythms advanced and delayed. Our results show a striking relationship between the timing of daytime production of melatonin and the timing of daytime naps. This suggests that abnormally timed endogenous melatonin may induce sleepiness in blind subjects.
Does culture matter in ABA-based autism interventions? Parent and professional experiences in the UK and China (2017)

The present study compared cultural differences in the UK and China in relation to Applied Behaviour Analysis (ABA)-based interventions for children with autism. In the UK, seven participants were interviewed (five professionals and two parents of children with autism). In China, eight participants took part in interviews (five professionals and three parents). Marked cultural and policy differences were found in the delivery of ABA-based early interventions for children with autism in the UK and China, e.g., home vs. school programmes.
Absolute requirement for GTP in activation of human neutrophil NADPH oxidase in a cell-free system: role of ATP in regenerating GTP. (1992)

Guanine and/or adenine nucleotides appear to be involved in the activation of the superoxide-generating NADPH oxidase of phagocytic cells. Their precise roles, however, are unclear, as much of the evidence for their involvement comes from experiments in which nucleotides have been added to complex systems already rich in both endogenous nucleotides and enzymes capable of interconverting them. To circumvent this problem we have examined the role of nucleotides in neutrophil NADPH oxidase activation by using a cell-free system in which adenine and guanine nucleotide concentrations were carefully controlled and monitored by (i) depletion of endogenous nucleotides by extensive dialysis and charcoal treatment; (ii) reconstitution of the depleted system with reagents analyzed for purity; and (iii) measurement of nucleotide levels in cytosol preparations and in oxidase reaction mixtures by HPLC analysis. In contrast to previous reports that have demonstrated only a several-fold enhancement of oxidase activity by GTP or its analogs, we have shown that oxidase activation was absolutely dependent upon GTP in reactions containing dialyzed cytosol in which the total endogenous nucleotide levels were reduced by greater than 99.5%. Kinetic studies revealed that GTP is required at or before the rate-limiting step in oxidase activation. Two nonhydrolyzable analogs of GTP, guanosine 5'-(gamma-thio)triphosphate and guanylyl imidodiphosphate, were even more active than GTP, suggesting the involvement of one or more GTP-binding proteins. In contrast, ATP was neither necessary nor sufficient for oxidase activation. If reaction mixtures were contaminated with GDP and/or GMP, however, ATP (but not its nonhydrolyzable analog adenylyl imidodiphosphate) could indirectly support oxidase activation by means of endogenous enzymes that catalyze the ATP-dependent conversion of GMP and GDP to GTP.
Switched-capacitor building blocks for adaptive systems (1981)

A number of switched-capacitor (SC) building blocks useful in adaptive systems are presented. These include a phase-lock loop, a tracking filter, a second-order equalizer with programmable gain, zeros' frequency and zeros' Q factor, a quadrature sine-wave generator, and a synchronous demodulator. It is shown, how a number of these signal processing blocks can be combined together to produce an adaptive channel equalizer. The operation of most of the circuits presented has been verified using discrete prototypes.
A Model for Calculating the Uniformity of Applications from Lateral Move Irrigation (1988)

Spatial variations in the depths of water applied over fields irrigated by lateral move irrigation machines occur as a result of a large number of factors. Most of these factors have been analysed individually and sometimes in combination but a model incorporating all factors is not available to designers. In this paper the sources and significance of the variability of irrigation applications are discussed. A model for calculating the uniformity of applied depths from lateral move machines is described, incorporating all the factors which influence applied depths. The grid spacing to be used in the calculations and its relationship to the plant root zone extent is discussed. The effect of varying the grid spacing is illustrated using applied depths calculated along a single transect across a field.
Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients. (1994)

To determine the optimal conditions for preparation of serum specimens for quantitative hepatitis C virus RNA determination, patient samples were processed such that differences in time from clot formation to centrifugation, centrifugation to separation of serum and collection of serum until freezing could be independently assessed. The effects of multiple cycles of freezing and thawing were also determined. There was progressive and significant loss of hepatitis C virus RNA activity when the time from the formation of the clot until centrifugation was longer than 2 hr. This reduction reached 32% after 6 hr and 49% after 24 hr. If centrifugation was performed immediately after formation of the clot, loss of hepatitis C virus RNA activity was reduced to less than 10% even though the serum remained unseparated from the clot for up to 6 hr. Centrifugation of blood through a paraffin plug (serum separator tube) prevented loss of hepatitis C virus RNA activity for up to 24 hr. There was no loss of hepatitis C virus RNA activity with up to three freeze-thaw cycles. When patient specimens were prepared under these optimal conditions, the sensitivity of the quantitative branched DNA signal amplification assay in patients with hepatitis C virus infection was 83% and the specificity in patients with liver disease was 100%. Fluctuations in hepatitis C virus RNA levels were shown to correlate with biochemical changes observed in patients treated with recombinant interferon-alpha 2b. These data demonstrate that improper or inconsistent methods of serum preparation may result in falsely low and unreliable levels of hepatitis C virus RNA.(ABSTRACT TRUNCATED AT 250 WORDS)
Interpretable Convolutional Neural Networks (2018)

This paper proposes a method to modify a traditional convolutional neural network (CNN) into an interpretable CNN, in order to clarify knowledge representations in high conv-layers of the CNN. In an interpretable CNN, each filter in a high conv-layer represents a specific object part. Our interpretable CNNs use the same training data as ordinary CNNs without a need for any annotations of object parts or textures for supervision. The interpretable CNN automatically assigns each filter in a high conv-layer with an object part during the learning process. We can apply our method to different types of CNNs with various structures. The explicit knowledge representation in an interpretable CNN can help people understand the logic inside a CNN, i.e. what patterns are memorized by the CNN for prediction. Experiments have shown that filters in an interpretable CNN are more semantically meaningful than those in a traditional CNN. The code is available at https://github.com/zqs1022/interpretableCNN.
Inhaled Nitric Oxide in Preterm Infants Undergoing Mechanical Ventilation (2006)

Inhaled nitric oxide therapy improves the pulmonary outcome for premature infants who are at risk for bronchopulmonary dysplasia when it is started between 7 and 21 days of age and has no apparent short-term adverse effects. (ClinicalTrials.gov number, NCT00000548 [ClinicalTrials.gov] .).
Coverage and Rate Analysis for Millimeter Wave Cellular Networks (2014)

Millimeter wave (mmWave) holds promise as a carrier frequency for fifth generation cellular networks. Because mmWave signals are sensitive to blockage, prior models for cellular networks operated in the ultra high frequency (UHF) band do not apply to analyze mmWave cellular networks directly. Leveraging concepts from stochastic geometry, this paper proposes a general framework to evaluate the coverage and rate performance in mmWave cellular networks. Using a distance-dependent line-of-site (LOS) probability function, the locations of the LOS and non-LOS base stations are modeled as two independent non-homogeneous Poisson point processes, to which different path loss laws are applied. Based on the proposed framework, expressions for the signal-to-noise-and-interference ratio (SINR) and rate coverage probability are derived. The mmWave coverage and rate performance are examined as a function of the antenna geometry and base station density. The case of dense networks is further analyzed by applying a simplified system model, in which the LOS region of a user is approximated as a fixed LOS ball. The results show that dense mmWave networks can achieve comparable coverage and much higher data rates than conventional UHF cellular systems, despite the presence of blockages. The results suggest that the cell size to achieve the optimal SINR scales with the average size of the area that is LOS to a user.
Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters (2009)

Species of Aspergillus produce a diverse array of secondary metabolites, and recent genomic analysis has predicted that these species have the capacity to synthesize many more compounds. It has been possible to infer the presence of 55 gene clusters associated with secondary metabolism in Aspergillus flavus; however, only three metabolic pathways-aflatoxin, cyclopiazonic acid (CPA) and aflatrem-have been assigned to these clusters. To gain an insight into the regulation of and to infer the ecological significance of the 55 secondary metabolite gene clusters predicted in A. flavus, we examined their expression over 28 diverse conditions. Variables included culture medium and temperature, fungal development, colonization of developing maize seeds and misexpression of laeA, a global regulator of secondary metabolism. Hierarchical clustering analysis of expression profiles allowed us to categorize the gene clusters into four distinct clades. Gene clusters for the production of aflatoxins, CPA and seven other unknown compound(s) were identified as belonging to one clade. To further explore the relationships found by gene expression analysis, aflatoxin and CPA production were quantified under five different cell culture environments known to be conducive or nonconducive for aflatoxin biosynthesis and during the colonization of developing maize seeds. Results from these studies showed that secondary metabolism gene clusters have distinctive gene expression profiles. Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus.
Array expansion (2014)

A common problem in restructuring programs for vector or parallel execution is the suppression of false dependencies which originate in the reuse of the same memory cell for unrelated values. The method is simple and well understood in the case of scalars. This paper gives the general solution for the case of arrays. The expansion is done in two steps: first, modify all definitions of the offending array in order to obtain the single assignment property. Then, reconstruct the original data flow by adapting all uses of the array. This is done with the help of a new algorithm for solving parametric integer programs. The technique is quite general and may be used for other purposes, including program checking, collecting array predicates, etc.
A glow discharge treatment to immobilize poly(ethylene oxide)/poly(propylene oxide) surfactants for wettable and non-fouling biomaterials (1992)

A non-fouling (protein resistant) polymer surface was achieved using an argon glow discharge treatment of a polyethylene surface which had been precoated with various poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) tri-block copolymer surfactants. The surfactant is first deposited on the polymer surface via a solvent swelling and evaporation method. Then the coated surfactant is immobilized on the substrate surface by an inert gas discharge treatment. ESCA and water contact angle () measurements on treated and solvent washed surfaces show significant increases in both surface O/C ratios and surface water wettability (0 < 30°) compared to LDPE control surfaces, revealing the presence of PEO on the treated surfaces. A great reduction of fibrinogen adsorption on the modified surfaces is also observed for the highest PEO content surfactants. This simple surface modification process may have wide applicability to obtain wettable polymer surfaces in general, and non-fouling biomaterial surfaces in specific.