gebhart/patrepeval huggingface dataset:
Nanosecond laser induced ignition thresholds and reaction velocities of energetic bimetallic nanolaminates (2008)

Thresholds for optically igniting self-propagating reactions are quantified for energetic Ni/Ti, Co/Al, and Al/Pt nanolaminates, where smaller enthalpy material pairs required larger laser ignition fluences. The threshold fluences (J/cm2) for ignition by 30 ns laser pulses focused to ∼8 μm spot size varied from 720 to 15 000 J/cm2 for Ni/Ti, 8.6 to 380 J/cm2 for Co/Al, and 3.2 to 27 J/cm2 for Al/Pt. Conversely, smaller enthalpy nanolaminates exhibited reduced steady-state propagation speeds ranging from 0.05 to 0.9 m/s for Ni/Ti, 0.6 to 8.5 m/s for Co/Al, and 24 to 73 m/s for Al/Pt. Increasing the laser spot diameter tenfold reduced the ignition threshold fluence by as much as two orders of magnitude.
An analysis of pilot contamination on multi-user MIMO cellular systems with many antennas (2011)

This paper considers a two-cell cellular system with multiple antennas at the base station (BS) and single antenna user terminals. In such a scenario, the presence of channel state information (CSI) at the BS is essential for efficient system performance. In reciprocal TDD systems, CSI can be obtained via uplink training. Since only finite time-frequency resources are available, such uplink training generally must be performed using non-orthogonal resources (for different users), leading to pilot contamination between users who train simultaneously. In particular, we analyze the rate of convergence of SINR (in presence of pilot contamination) as the number of antennas (M) at the BS increases to an infinite limit. The effect of SNR and the fading coefficients of the user channels on this rate of convergence is also determined.
Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines. (1980)

Approximately 30 to 40% of human leukemic cell lines are completely deficient in the purine catabolic enzyme 5'-methylthioadenosine phosphorylase. Using two 5'-methylthioadenosine phosphorylase-negative leukemias, we have for the first time been able to measure the synthesis and biological effects of 5'-methylthioadenosine (MTA) in intact mammalian tumor cells. Malignant cells lacking this enzyme, unlike enzyme-positive cells, excreted MTA into the culture medium at a rate of 0.58 to 0.70 nmol/hr/mg protein. The production of the nucleoside was inhibited effectively by nontoxic concentrations of methylglyoxal bis(guanylhydrazone), a putrescine-depending S-adenosylmethionine decarboxylase inhibitor, and also by spermidine and spermine but was enhanced by putrescine. In a reciprocal fashion, MTA at low concentrations progressively increased both the synthesis and concentration of putrescine but suppressed spermine production. The unique alterations in polyamine metabolism induced by elevated MTA levels could offer a selective growth advantage to the 5'-methylthioadenosine phosphorylase-deficient cells and thus may be related to the high frequency of this enzyme deficiency among human leukemic cell lines.
Access methods for text (1985)

This paper compares text retrieval methods intended for office systems. The operational requirements of the office environment are discussed, and retrieval methods from database systems and from information retrieval systems are examined. We classify these methods and examine the most interesting representatives of each class. Attempts to speed up retrieval with special purpose hardware are also presented, and issues such as approximate string matching and compression are discussed. A qualitative comparison of the examined methods is presented. The signature file method is discussed in more detail.
The Diagnosis and Medical Management of Advanced Neuroendocrine Tumors (2004)

Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms that originate from endocrine glands such as the pituitary, the parathyroids, and the (neuroendocrine) adrenal, as well as endocrine islets within glandular tissue (thyroid or pancreatic) and cells dispersed between exocrine cells, such as endocrine cells of the digestive (gastroenteropancreatic) and respiratory tracts. Conventionally, NETs may present with a wide variety of functional or nonfunctional endocrine syndromes and may be familial and have other associated tumors. Assessment of specific or general tumor markers offers high sensitivity in establishing the diagnosis and can also have prognostic significance. Imaging modalities include endoscopic ultrasonography, computed tomography and magnetic resonance imaging, and particularly, scintigraphy with somatostatin analogs and metaiodobenzylguanidine. Successful treatment of disseminated NETs requires a multimodal approach; radical tumor surgery may be curative but is rarely possible. Well-differentiated and slow-growing gastroenteropancreatic tumors should be treated with somatostatin analogs or alpha-interferon, with chemotherapy being reserved for poorly differentiated and progressive tumors. Therapy with radionuclides may be used for tumors exhibiting uptake to a diagnostic scan, either after surgery to eradicate microscopic residual disease or later if conventional treatment or biotherapy fails. Maintenance of the quality of life should be a priority, particularly because patients with disseminated disease may experience prolonged survival.
Osteoclasts and odontoclasts: signaling pathways to development and disease (2010)

Osteoclasts are cells essential for physiologic remodeling of bone and also play important physiologic and pathologic roles in the dentofacial complex. Osteoclasts and odontoclasts are necessary for tooth eruption yet result in dental compromise when associated with permanent tooth internal or external resorption. The determinants that separate their physiologic and pathologic roles are not well delineated. Clinical cases of primary eruption failure and root resorption are challenging to treat. Mineralized tissue resorbing cells undergo a fairly well characterized series of differentiation stages driven by transcriptional mediators. Signal transduction via cytokines and integrin-mediated events comprise the detailed pathways operative in osteo/odontoclastic cells and may provide insights to their targeted regulation. A better understanding of the unique aspects of osteoclastogenesis and osteo/odontoclast function will facilitate effective development of new therapeutic approaches. This review presents the clinical challenges and delves into the cellular and biochemical aspects of the unique cells responsible for resorption of mineralized tissues of the craniofacial complex.
Geometrically consistent stereo seam carving (2011)

Image retargeting algorithms attempt to adapt the image content to the screen without distorting the important objects in the scene. Existing methods address retargeting of a single image. In this paper we propose a novel method for retargeting a pair of stereo images. Naively retargeting each image independently will distort the geometric structure and make it impossible to perceive the 3D structure of the scene. We show how to extend a single image seam carving to work on a pair of images. Our method minimizes the visual distortion in each of the images as well as the depth distortion. A key property of the proposed method is that it takes into account the visibility relations between pixels in the image pair (occluded and occluding pixels). As a result, our method guarantees, as we formally prove, that the retargeted pair is geometrically consistent with a feasible 3D scene, similar to the original one. Hence, the retargeted stereo pair can be viewed on a stereoscopic display or processed by any computer vision algorithm. We demonstrate our method on a number of challenging indoor and outdoor stereo images.
Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus (2001)

The expression level of the human telomerase reverse transcriptase (hTERT) is a rate-limiting determinant of telomerase activity. Several alternatively spliced variants of hTERT transcript are currently known. We have studied the expression of the splicing variants arising in the transcript encoding the reverse transcriptase domain, and have compared this to the telomerase activity in 27 endometria, 14 myometria and 18 endometrial carcinomas. Telomerase activity and the full-length hTERT transcript were observed in endometrial samples from the proliferative and early secretory phases, but not in those from the late secretory phase. Steady-state expression of the hTERT splicing variant entirely lacking exon 7 and exon 8 was observed in the endometria throughout the menstrual cycle. In the analysed myometria, this type of splicing variant was the most commonly detected, and telomerase activity occurred in only three samples. In both endometria and myometria, the expression of the full-length transcript correlated well with the telomerase activity. In each of the endometrial carcinomas, telomerase activity was detected and the full-length transcript was found together with varying combinations of deletion splicing variants. These results suggest that regulation of splicing in the transcript encoding the hTERT reverse transcriptase domain is associated with telomerase activation in uterine tissues.
Herbicide-Resistant Crops: Agricultural, Economic, Environmental, Regulatory, and Technological Aspects (1996)

Herbicide-Resistant Crops - Background and Perspectives The Technology: Mechanisms of Action and Resistance to Herbicide. Techniques for Producing Herbicide-Resistant Crops. New Weed Control Opportunities: Development of Soybeans with a Roundup Ready Gene. Phospinothricin-Resistant Crops. Cotton Weed Control Using the BXN System. Triazine-Resistant Crops: The Agronomic Impact and Physiological Consequences of Chloroplast Mutation. Sulfonylurea Herbicide-Resistant Crops. Management.
Intercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation (2002)

The production of functional female gametes is essential for the propagation of all vertebrate species. The growth of oocytes within ovarian follicles and their development to mature eggs have fascinated biologists for centuries, and scientists have long realized the importance of the ovarian follicle's somatic cells in nurturing oogenesis and delivering the oocyte to the oviduct by ovulation. Recent studies have revealed key roles of the oocyte in folliculogenesis and established that bidirectional communication between the oocyte and companion somatic cells is essential for development of an egg competent to undergo fertilization and embryogenesis. The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action.
Pricing the Internet (1996)

This is a paper about pricing the Internet. The focus is the use of pricing for usage of the infrastructure for transmitting and receiving IP packets, rather than of services such as WWW, FTP, Archie, Gopher, etc. In this we propose subscription based pricing, and a mechanism based on dynamic host address allocation drawn from a set of separately routed addresses to give priority levels. The idea of subscriptions here is not that all service pricing should be achieved through subscriptions per se. They are seen as a way of policing priority access to service bottlenecks, and thus can be deployed incrementally at weak interconnection points in a network, or between ISPs. Users of these subscriptions could easily be entire organisations (represented by network numbers, or CIDRized collections of network numbers, or ASs and so on). These organisations could employ refinement techniques to provide more usage oriented charging if needed.
Purification, characterisation and reaction mechanism of monofunctional 2‐hydroxypentadienoic acid hydratase from Escherichia coli (1998)

2-Hydroxypentadienoic acid hydratase is found on many bacterial catabolic pathways responsible for the degradation of aromatic compounds. Monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli has been purified 3800-fold to homogeneity, using enzymatically generated 2-hydroxypentadienoic acid as substrate. The purified 28-kDa protein requires a divalent metal ion for activity, optimum activity being obtained with Mn2+. Steady-state kinetic parameters were measured (Km = 41 +/- 4 microM, k(cat) = 450 s(-1)), the enzyme exhibiting substrate inhibition at high substrate concentrations. The pH/rate profile and inhibition by group-specific reagents were examined, and evidence was obtained for essential cysteine and tryptophan residues. An amino acid sequence alignment of the inferred amino acid sequence with nine other sequences was carried out and revealed several conserved sequence motifs. The substrate for the enzymatic reaction was found to be the dienol tautomer of 2-hydroxypentadienoic acid. Analysis of the reaction products by HPLC confirmed the identity of the 4-hydroxy-2-ketopentanoic acid product. Analogues of possible reaction intermediates were tested as inhibitors, and sodium oxalate was found to act as a potent enzyme inhibitor (Ki = 4.9 +/- 0.7 microM). The potent inhibition by oxalate is consistent with a mechanism in which tautomerisation to 2-ketopent-3-enoic acid takes place at the active site, followed by conjugate addition of water.
Alkaline Proteinase Inhibitor of Pseudomonas aeruginosa (2000)

The apr locus of Pseudomonas aeruginosa encodes alkaline proteinase (APR), a member of the metzincin metalloendopeptidase superfamily, and an 11.4-kDa alkaline proteinase inhibitor (APRin). We describe here the expression in Escherichia coli and characterization of full-length and N-terminally truncated APRin proteins. Fluorescence and circular dichroism spectra indicated that the recombinant proteins were folded into native-like structures. Analytical ultracentrifugation showed that APRin was monomeric and formed a 1:1 complex with APR. Binding of wild-type APRin to APR occurred with association (k(on)) and dissociation (k(off)) rate constants of 0.29 +/- 0.06 x 10(6) m(-1) s(-1) and 1.15 +/- 0.08 x 10(-6) s(-1) to give an equilibrium dissociation constant (K(D)) of approximately 4 x 10(-12) m (25 degrees C, pH 7.0, ionic strength 2.4 m). The association rate decreased by approximately 2-fold in 20% glycerol and increased by approximately 3-fold in 0.1 m NaCl. The glycerol effect suggests a diffusion-limited reaction, and the small salt effect indicates that electrostatic interactions contribute little to binding. Deletion of residues 1-10, 1-6, or 6-10 abolished inhibition, and deletion of residues 1-2, 1-3, 1-4, and 1-5 resulted in a progressively decreased affinity of APRin for APR (K(D) = 0.12 micrometer the Delta(1-5) mutant). Substitution of APRin residues 6-10 with a (Gly)(5) or (Pro)(5) linker restored inhibitory activity of the Delta(6-10) mutant but with a 100- and 50-fold reduction in K(D). Log k(on) for the full-length and truncated inhibitors correlated with the solvent-accessible surface area of their N-terminal regions, suggesting that increased interactions and/or desolvation of these residues in the transition state for binding contribute to the enhanced association rate. Treatment of APRin with pseudolysin, also secreted by P. aeruginosa, resulted in removal of residues 1-5. APRin was neither an inhibitor nor a substrate of other metzincins, including collagenase or gelatinases A or B.
A general approach to the synthesis of 1,6-, 1,7-, and 1,8-naphthyridines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general approach to the synthesis of 1,6-, 1,7-, and 1,8-naphthyridinesJames A. TurnerCite this: J. Org. Chem. 1990, 55, 15, 4744–4750Publication Date (Print):July 1, 1990Publication History Published online1 May 2002Published inissue 1 July 1990https://pubs.acs.org/doi/10.1021/jo00302a049https://doi.org/10.1021/jo00302a049research-articleACS PublicationsRequest reuse permissionsArticle Views1946Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inhalt des Kontrollrechts und seine Wahrnehmung durch Große und Kleine Anfragen, Fragestunden und Aktuelle Stunden (1982)

I. 1. Da für das parlamentarische Regierungssystem es ein Wesensmerkmal ist, daß die Regierung dem Parlament Rede und Antwort stehen muß, bedarf es einer Regelung, wer für das Parlament und in welcher Form fragen kann.
Second Generation Antisense Oligonucleotides—Inhibition of PKC-α andc-rafKinase Expression by Chimeric Oligonucleotides Incorporating 6″-Substituted Carbocyclic Nucleosides and 2″-O-Ethylene Glycol Substituted Ribonucleosides (1997)

Abstract 6′-substituted carbocyclic deoxyribonucleosides and 2′-O-ethylene glycol substituted ribonucleosides have been evaluated as building blocks for antisense oligonucleotides. Within the former class 6′-hydroxy substituted building blocks in combination with internucleoside phosphorothioate linkages have the potential to enhance antisense activity. 2′-O-ethylene glycol substituted ribonucleosides generally allow for the construction of potent antisense oligonucleotides with reduced phosphorothioate content, but differences exist in their effects on biological activity in cell culture in spite of virtually identical effects on RNA-binding affinity. Activity enhancement was most pronounced for a 2′-O-methoxyethyl substituent.
Protein Microarray Signature of Autoantibody Biomarkers for the Early Detection of Breast Cancer (2010)

Cancer patients spontaneously generate autoantibodies (AAb) to tumor-derived proteins. To detect AAb, we have probed novel high-density custom protein microarrays (NAPPA) expressing 4988 candidate tumor antigens with sera from patients with early stage breast cancer (IBC), and bound IgG was measured. We used a three-phase serial screening approach. First, a prescreen was performed to eliminate uninformative antigens. Sera from stage I-III IBC (n = 53) and healthy women (n = 53) were screened for AAb to all 4988 protein antigens. Antigens were selected if the 95th percentile of signal of cases and controls were significantly different (p < 0.05) and if the number of cases with signals above the 95th percentile of controls was significant (p < 0.05). These 761 antigens were screened using an independent set of IBC sera (n = 51) and sera from women with benign breast disease (BBD) (n = 39). From these, 119 antigens had a partial area under the ROC curve (p < 0.05), with sensitivities ranging from 9-40% at >91% specificity. Twenty-eight of these antigens were confirmed using an independent serum cohort (n = 51 cases/38 controls, p < 0.05). Using all 28 AAb, a classifier was identified with a sensitivity of 80.8% and a specificity of 61.6% (AUC = 0.756). These are potential biomarkers for the early detection of breast cancer.
25th Anniversary Article: Scalable Multiscale Patterned Structures Inspired by Nature: the Role of Hierarchy (2013)

Multiscale, hierarchically patterned surfaces, such as lotus leaves, butterfly wings, adhesion pads of gecko lizards are abundantly found in nature, where microstructures are usually used to strengthen the mechanical stability while nanostructures offer the main functionality, i.e., wettability, structural color, or dry adhesion. To emulate such hierarchical structures in nature, multiscale, multilevel patterning has been extensively utilized for the last few decades towards various applications ranging from wetting control, structural colors, to tissue scaffolds. In this review, we highlight recent advances in scalable multiscale patterning to bring about improved functions that can even surpass those found in nature, with particular focus on the analogy between natural and synthetic architectures in terms of the role of different length scales. This review is organized into four sections. First, the role and importance of multiscale, hierarchical structures is described with four representative examples. Second, recent achievements in multiscale patterning are introduced with their strengths and weaknesses. Third, four application areas of wetting control, dry adhesives, selectively filtrating membranes, and multiscale tissue scaffolds are overviewed by stressing out how and why multiscale structures need to be incorporated to carry out their performances. Finally, we present future directions and challenges for scalable, multiscale patterned surfaces.
139: A journey to performance excellence utilizing the Malcolm Baldrige model in a bone marrow transplant unit (2007)

Continuous quality improvement is critical for organizations as they strive to provide performance excellence. The Baldrige award used to recognize role model behaviors is the highest achievement in the United States for business and service excellence. Health care currently comprises over half of all applicants. The approach is unique in that it is not prescriptive, rather it provides a framework for the description of what the applicant does, how they perform this service and how well they compare to others providing similar services. Although few win, applying forces the applicant to examine how they perform core services using 6 broad categories: Leadership, Strategic Planning, Customer Service, Information management, Human Resource Focus and Process management. For each a results section evaluates how well you perform relative to your competition. Such an approach is well suited to transplant centers. To prepare our application we divided into groups focusing on each core area to prepare answers to the criteria questions addressing issues such as ethics, employee and client satisfaction. These were reviewed by senior leadership to create the final document. As we prepared opportunities for improvement (OFIs) were identified, new processes and corresponding measurement tools were developed. Even before submission this allowed our program to refine and align strategic goals and integrate these throughout the entire BMT team. It also significantly enhanced team building by providing an atmosphere of ownership. For some organizations self assessment may be sufficient. Programs who formally apply are evaluated by specially trained examiners who provide feedback on strengths and OFIs based on the criterion outlined in the application. Programs who move forward to consensus or site visit receive feedback at the highest level achieved. Importantly the feedback does not suggest how to improve but rather highlights areas that may not have been addressed and why they are important to achieving your goals. The program determines how best to address these gaps. As a result of our feedback some changes we implemented included modifying the leadership structure, developing a formal strategic plan, new surveys to capture referring physician satisfaction and preferences. Using the Baldrige model aligns leaders, provides focus to organizational priorities and gives an outside perspective measured against other similar high performing organizations.