gebhart/patrepeval huggingface dataset:
Palynology as a palaeoenvironmental indicator in the Brent Group, northern North Sea (1992)

Abstract The Brent Group of the northern North Sea can be subdivided into a series of 12 assemblage units on the basis of palynomorph and kerogen abundances. These assemblages, which can be identified on a regional basis, have been recognized extensively throughout wells of the Brent Group depositional area. They represent changes in the environment, kerogen source and depositional setting and can be linked to lithostratigraphical units. Changes in assemblages through the Brent Group reflect an initial restricted marine environment followed by progradation in a regressive regime. Progradation ceased and the maximum point of regression occurred within the ‘Mid’ Ness Formation, after which deposition occurred within an abandonment and transgressive regime. These features are defined by palynological data, thus providing input into the regional understanding of Brent Group deposition. The palynological assemblages of the Brent Group are illustrated with reference to two wells: 211/18a-A31 from the Thistle Field and 3/3-5A from the Ninian Field. Palynomorph assemblages within the Brent Group are largely facies controlled and have an intimate relationship with lithofacies. The identification of these assemblages, therefore, allows for the positive identification of individual lithostratigraphical and reservoir units, particularly in problematic sections where stratigraphical interpretations based on other disciplines are hampered by faulting and truncation or lack of conventional core material and wireline log data, particularly where sidewall core samples are available.
Compartmentalized expression of RANTES in a murine model of endotoxemia. (1995)

Systemic exposure to LPS initiates a complex sequence of events culminating in organ-specific leukocyte recruitment and end organ injury. We hypothesized that RANTES, a C-C chemokine with potent M phi (mononuclear phagocyte) chemotactic activity, is expressed in vivo in response to endotoxemia, and that this protein may play an important role in the recruitment of M phi to the lung. CD-1 mice were challenged with LPS (200 micrograms), resulting in a maximal fourfold increase in polymorphonuclear leukocyte (neutrophils) at 6 h post LPS, and a 2.4-fold increase in numbers of M phi within lung minces at 24 h. A time-dependent increase in RANTES mRNA was detected in lung after LPS treatment, whereas minimal quantities of RANTES mRNA were detected in blood buffy coats and liver. Furthermore, treatment with LPS resulted in time-dependent increase in RANTES protein within lung homogenates, with immunolocalization to alveolar epithelial cells. The pretreatment of mice with goat anti-RANTES Ab significantly inhibited the influx of lung M phi, but not polymorphonuclear leukocyte and lymphocytes, at 24 h post-LPS challenge. Lastly, the pretreatment of animals with soluble TNF receptor: Ig construct 2 h before LPS resulted in a 60% reduction in steady state levels of RANTES mRNA within lung homogenates at 4 h post-LPS. Our observations suggest that RANTES represents an important mediator of lung M phi recruitment in the setting of endotoxemia, and that the expression of RANTES in vivo is dependent upon the endogenous production of TNF.
Antenna-Pattern Diversity Versus Space Diversity for Use at Handhelds (2004)

This paper investigates diversity for dual-antenna systems operating in indoor environments. First, an approximated equation of the diversity gain is derived for different combining techniques. These theoretical results show that the two-term approximation, as generally used in the literature , is too rough an estimate. Consequently, a new six-term approximation is derived. Next, it is demonstrated by a comparison of theoretical and experimental diversity gain values that, due to mutual coupling between the two antennas in practice, the diversity gain will not approach 0 dB if the distance between the two antennas approaches zero. Finally, it is concluded from measurements at 900 MHz that antenna-pattern diversity is a better choice than space diversity for use at handhelds.
Matching 3D models with shape distributions (2002)

Measuring the similarity between 3D shapes is a fundamental problem, with applications in computer vision, molecular biology, computer graphics, and a variety of other fields. A challenging aspect of this problem is to find a suitable shape signature that can be constructed and compared quickly, while still discriminating between similar and dissimilar shapes. In this paper, we propose and analyze a method for computing shape signatures for arbitrary (possibly degenerate) 3D polygonal models. The key idea is to represent the signature of an object as a shape distribution sampled from a shape function measuring the global geometric properties of an object. The primary motivation for this approach is to reduce the shape matching problem to the comparison of probability distributions, which is simpler than traditional shape matching methods that require pose registration, feature correspondence or model fitting. We find that the dissimilarities between sampled distributions of simple shape functions (e.g. the distance between two random points on a surface) provide a robust method for discriminating between classes of objects (e.g. cars versus airplanes) in a moderately sized database, despite the presence of arbitrary translations, rotations, scales, reflections, tessellations, simplifications and model degeneracies. They can be evaluated quickly, and thus the proposed method could be applied as a pre-classifier in an object recognition system or in an interactive content-based retrieval application.
Ribonucleases from the extreme thermophilic archaebacterium S. solfataricus (1993)

A purification procedure consisting of DEAE-Sephacel chromatography, heparin-Sepharose CL-6B chromatography and Mono-S chromatography led to the isolation of three proteins endowed with RNase activity from the thermoacidophilic archaebacterium Sulfolobus solfataricus. They were referred to as p1, p2 and p3, according to their elution order from the Mono-S column. Complete amino acid sequence of p2 and partial sequence of p3 displayed high sequence similarity to the 7-kDa DNA-binding proteins previously isolated in Sulfolobus strains [Choli, T., Wittman-Liebold, B. & Reinhardt, R. (1988) J. Biol. Chem. 263, 7087-7093]. The molecular mass of p2, calculated from sequence data, was 7.02 kDa, which compares fairly well with the value of 7.4 kDa determined by SDS/PAGE. Gel filtration of the molecule under native conditions displayed, however, a largely prevailing form with an assessed molecular mass of 13.0 kDa, which points to a dimeric structure. Kinetic characterization of protein p2 showed a broad pH optimum in the range 6.7-7.6 using yeast RNA as substrate; also, it was shown that activity was unaffected by EDTA, Mg2+ and phosphate. The enzyme did not accept as substrate any homopolyribonucleotide, which points to a rather narrow substrate specificity. This was also confirmed by incubating p2 with tRNA(fMet)Met (fMet, N-formylmethionine) from Escherichia coli: the hydrolysis products were thus identified as 3'-phosphooligonucleotides.
Wireless Power Transmission: From Far Field to Near Field (2013)

Wireless power has been a topic of interest from the early 20th century until today. This paper traces the history of wireless power transmission starting with Nikola Tesla, continuing on to experiments with beaming power using microwaves. Examining the difference between near-field and far-field techniques, this paper continues into modern times explaining why near-field technique is more suitable for consumer electronic devices and exploring the near-field transmission of power via the magnetic field. Examples of short-range and midrange wireless power systems are explored.
TRAVEL DECISION MAKING - THE ROLE OF HABIT (2021)

The complexity of travel decision making is widely recognized and has previous been studied by the means of grand models and process studies. This study has used the Self-Reported Habit Index of Verplanken and Orbell (2003) to measure habit strength in 23 statements concerning travel decision making. The four subdecisions of particular interest in this study were; where and when to go on vacation, what to do, as well as how to travel to the chosen destination. The developed instrument unfolds a well recognized structure of travel behavior, results which validate the statements of SRHI and its applicability to the field of tourism. This research adds to the field of travel decision making by emphasizing the possibility to identify sub-decisions that are made out of habit and to use habit as a platform for tourist segmentation.
Small-molecule cyclic αVβ3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion (2007)

Abnormal adhesion of sickle red blood cells (SS RBCs) to vascular endothelium may play an important role in vasoocclusion in sickle cell disease. Accruing evidence shows that endothelial alpha V beta 3-integrin has an important role in SS RBC adhesion because of its ability to bind several adhesive proteins implicated in this interaction. In the present studies, we tested therapeutic efficacy of small-molecule cyclic pentapeptides for their ability to block alpha V beta 3-mediated SS RBC adhesion by using two well-established assay systems, i.e., cultured human umbilical vein endothelial cells (HUVEC) and artificially perfused mesocecum vasculature of the rat under flow conditions. We tested the efficacy of two RGD-containing cyclic pentapeptides, i.e., cRGDFV (EMD 66203) and cRGDF-ACHA (alpha-amino cyclohexyl carboxylic acid) (EMD 270179), based on their known ability to bind alpha V beta 3. An inactive peptide, EMD 135981 (cR beta-ADFV) was used as control. Cyclization and the introduction of D-Phe (F) results in a marked increase in the ability of cyclic peptides to selectively bind alpha V beta 3 receptors. In the mesocecum vasculature, both EMD 66203 and EMD 270179 ameliorated platelet-activating factor-induced enhanced SS RBC adhesion, postcapillary blockage, and significantly improved hemodynamic behavior. Infusion of a fluorescent derivative of EMD 66203 resulted in colocalization of the antagonist with vascular endothelium. Also, pretreatment of HUVEC with either alpha V beta 3 antagonist resulted in a significant decrease in SS RBC adhesion. Because of their metabolic stability, the use of these cyclic alpha V beta 3 antagonists may constitute a novel therapeutic strategy to block SS RBC adhesion and associated vasoocclusion under flow conditions.
Chemistry of naturally occurring polyamines. 11. Unsaturated spermidine and spermine derivatives (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of naturally occurring polyamines. 11. Unsaturated spermidine and spermine derivativesSrinivasan Nagarajan and Bruce GanemCite this: J. Org. Chem. 1987, 52, 22, 5044–5046Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/jo00231a044https://doi.org/10.1021/jo00231a044research-articleACS PublicationsRequest reuse permissionsArticle Views628Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phylogenetic Analysis of the Main Neutralization and Hemagglutination Determinants of All Human Adenovirus Prototypes as a Basis for Molecular Classification and Taxonomy (2005)

Human adenoviruses (HAdV) are responsible for a wide spectrum of diseases. The neutralization epsilon determinant (loops 1 and 2) and the hemagglutination gamma determinant are relevant for the taxonomy of HAdV. Precise type identification of HAdV prototypes is crucial for detection of infection chains and epidemiology. epsilon and gamma determinant sequences of all 51 HAdV were generated to propose molecular classification criteria. Phylogenetic analysis of epsilon determinant sequences demonstrated sufficient genetic divergence for molecular classification, with the exception of HAdV-15 and HAdV-29, which also cannot be differentiated by classical cross-neutralization. Precise sequence divergence criteria for typing (<2.5% from loop 2 prototype sequence and <2.4% from loop 1 sequence) were deduced from phylogenetic analysis. These criteria may also facilitate identification of new HAdV prototypes. Fiber knob (gamma determinant) phylogeny indicated a two-step model of species evolution and multiple intraspecies recombination events in the origin of HAdV prototypes. HAdV-29 was identified as a recombination variant of HAdV-15 (epsilon determinant) and a speculative, not-yet-isolated HAdV prototype (gamma determinant). Subanalysis of molecular evolution in hypervariable regions 1 to 6 of the epsilon determinant indicated different selective pressures in subclusters of species HAdV-D. Additionally, gamma determinant phylogenetic analysis demonstrated that HAdV-8 did not cluster with -19 and -37 in spite of their having the same tissue tropism. The phylogeny of HAdV-E4 suggested origination by interspecies recombination between HAdV-B (hexon) and HAdV-C (fiber), as in simian adenovirus 25, indicating additional zoonotic transfer. In conclusion, molecular classification by systematic sequence analysis of immunogenic determinants yields new insights into HAdV phylogeny and evolution.
Frame synchronization using distributed sequences (2000)

Frame synchronization is traditionally achieved by inserting a given sequence periodically into the data stream. Here, a new method of synchronization is introduced in which the synchronization sequence is not contiguous, but is interleaved with the data symbols. The properties of these distributed sequences are investigated, and requirements are specified for detectability of these sequences when inserted in random data. Methods for constructing and searching for good sequences are presented. It is demonstrated that this new method reduces the probability of false synchronization over traditional methods in the presence of additive white Gaussian noise.
Role of thymidine in biochemical modulation: a review. (1987)

The role of thymidine in the treatment of cancer has been under clinical investigation for nearly a decade. Clinical trials have demonstrated that it lacks antitumor activity in its own right. In this review, the mechanism of action and rationale for the use of thymidine as a biochemical modulator of standard agents such as 5-fluorouracil, 1-beta-D-arabinofuranosylcytosine, and methotrexate are summarized. With this background, the clinical trials which have been conducted with thymidine, either alone or in combination, are described. We suggest a number of further studies of the role of thymidine in the biochemical modulation of antimetabolites.
Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits (1999)

The effects of atorvastatin (3 mg kg(-1)) and simvastatin (3 mg kg(-1)) on hepatic enzyme activities involved in very low density lipoprotein metabolism were studied in coconut oil/cholesterol fed rabbits. Plasma cholesterol and triglyceride levels increased 19 and 4 fold, respectively, after 7 weeks of feeding. Treatment with statins during the last 4 weeks of feeding abolished the progression of hypercholesterolaemia and reduced plasma triglyceride levels. 3-Hydroxy-3-methyl-glutaryl Coenzyme A reductase, acylcoenzyme A:cholesterol acyltransferase, phosphatidate phosphohydrolase and diacylglycerol acyltransferase activities were not affected by drug treatment. Accordingly, hepatic free cholesterol, cholesteryl ester and triglyceride content were not modified. Simvastatin treatment caused an increase (72%) in lipoprotein lipase activity without affecting hepatic lipase activity. Atorvastatin caused a reduction in hepatic phospholipid content and a compensatory increase in CTP:phosphocholine cytidylyl transferase activity. The results presented in this study suggest that, besides the inhibitory effect on 3-hydroxy-3-methyl-glutaryl Coenzyme A reductase, simvastatin and atorvastatin may have additional effects that contribute to their triglyceride-lowering ability.
In vitro and in vivo effects of lead on specific 3H-MK-801 binding to NMDA-receptors in the brain of mice. (1995)

The in vitro and vivo effects of lead on the NMDA-receptors in adult and juvenile mice were studied by means of receptor binding assays. Adult female NMRI-mice received 100 and 1,000 ppm lead as nitrate in their drinking water for 30 and 90 days. Perinatal exposure was achieved by treating gestating mice from the 5th day post conception with 0, 100 or 1,000 ppm lead in their drinking water. Characterization of the NMDA N-methyl-D-aspartate)-receptor was carried out ex vivo using binding studies on homogenates of the forebrain with the non competitive NMDA-antagonist 3H-MK-801. In vitro, complete inhibition of the radioligand binding was found with half maximal inhibiting concentrations (IC50-values) of 19.7 +/- 2.6 microM (SEM) in absence of amino acids and 9.5 +/- 0.9 in presence of glutamate and glycine. These concentrations are in a range which could be achieved in vivo, e.g. the lead content in the forebrain of juvenile mice treated with 1,000 ppm lead was 10.0 +/- 1.8 mumol/kg wet weight. It was speculated that lead binds at the zinc binding site. In the presence of amino acids and divalent cations, such as calcium or magnesium, low lead concentrations lead to a significant increase in receptor affinity. Analysis of the saturation experiments carried out on forebrain homogenates of lead-treated animals showed a slight increase in receptor density of 13 or 15% with an unchanged Kd-value only in the adult animals treated with 100 ppm lead and in absence of stimulating amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)
The sequence of human retinal S‐antigen reveals similarities with α‐transducin (1988)

The complete amino acid sequence of human retinal S-antigen (48 kDa protein), a retinal protein involved in the visual process has been determined by cDNA sequencing. The largest cDNA was 1590 base pairs (bp) and it contained an entire coding sequence. The similarity of nucleotide sequence between the human and bovine is approximately 80%. The predicted amino acid sequence indicates that human S-antigen has 405 residues and its molecular mass is 45050 Da. The amino acid sequence homology between human and bovine is 81%. There is no overall sequence similarity between S-antigen and other proteins listed in the National Biomedical Research Foundation (NBRF) protein data base. However, local regions of sequence homology with alpha-transducin (T alpha) are apparent including the putative rhodopsin binding and phosphoryl binding sites. In addition, human S-antigen has sequences identical to bovine uveitopathogenic sites, indicating that some types of human uveitis may in part be related to the animal model of experimental autoimmune uveitis (EAU).
Dynamic Nanoinscribing for Continuous and Seamless Metal and Polymer Nanogratings (2009)

Nanoscale grating structure can be utilized in many practical applications in optics, flat-panel displays, and biosensors. We present a dynamic nanoinscribing (DNI) technique for directly creating large-area, truly continuous nanograting patterns in a variety of metal or polymer materials with feature size down to sub-50 nm and at very high speed (10 cm/sec). DNI is carried out under either ambient temperature or with a brief heating time on the order of 10 micros, which minimizes damage on UV or thermosensitive functional materials. We also demonstrated future applications of the DNI process into the simple, one-step fabrication of split-ring resonator (SRR) structures for negative index materials.
Smarter presentations: exploiting homography in camera-projector systems (2002)

Standard presentation systems consisting of a laptop connected to a projector suffer from two problems: (1) the projected image appears distorted (keystoned) unless the projector is precisely aligned to the projection screen; (2) the speaker is forced to interact with the computer rather than the audience. This paper shows how the addition of an uncalibrated camera, aimed at the screen, solves both problems. Although the locations, orientations and optical parameters of the camera and projector are unknown, the projector-camera system calibrates itself by exploiting the homography between the projected slide and the camera image. Significant improvements are possible over passively calibrating systems since the projector actively manipulates the environment by placing feature points into the scene. For instance, using a low-resolution (160/spl times/120) camera, we can achieve an accuracy of /spl plusmn/3 pixels in a 1024/spl times/768 presentation slide. The camera-projector system infers models for the projector-to-camera and projector-to-screen mappings in order to provide two major benefits.
A simple energy-conserving system: Proton reduction coupled to proton translocation (2003)

Oxidative phosphorylation involves the coupling of ATP synthesis to the proton-motive force that is generated typically by a series of membrane-bound electron transfer complexes, which ultimately reduce an exogenous terminal electron acceptor. This is not the case with Pyrococcus furiosus, an archaeon that grows optimally near 100 degrees C. It has an anaerobic respiratory system that consists of a single enzyme, a membrane-bound hydrogenase. Moreover, it does not require an added electron acceptor as the enzyme reduces protons, the simplest of acceptors, to hydrogen gas by using electrons from the cytoplasmic redox protein ferredoxin. It is demonstrated that the production of hydrogen gas by membrane vesicles of P. furiosus is directly coupled to the synthesis of ATP by means of a proton-motive force that has both electrochemical and pH components. Such a respiratory system enables rationalization in this organism of an unusual glycolytic pathway that was previously thought not to conserve energy. It is now clear that the use of ferredoxin in place of the expected NAD as the electron acceptor for glyceraldehyde 3-phosphate oxidation enables energy to be conserved by hydrogen production. In addition, this simple respiratory mechanism readily explains why the growth yields of P. furiosus are much higher than could be accounted for if ATP synthesis occurred only by substrate-level phosphorylation. The ability of microorganisms such as P. furiosus to couple hydrogen production to energy conservation has important ramifications not only in the evolution of respiratory systems but also in the origin of life itself.
Fetal wound healing (2012)

Successful therapies that help minimize postnatal scar formation can be realized through understanding the cellular and molecular mechanisms of fetal regenerative wound healing. These insights will have implications not only for cutaneous wound healing, but also potentially for any disease process characterized by excessive fibroplasia.