gebhart/patrepeval huggingface dataset:
The Passionate Steward: Recovering Christian Stewardship from Secular Fundraising (2004)

Hyperlipemia rabbit models established with high cholesterol and fat diet were treated with direct moxibustion and medicinal cake-separated moxibustion. The post-treatment plasma 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha) and thromboxane B2 (TXB2) contents were determined by radioimmunoassay. Results indicated that the plasma 6-keto-PGF1alpha content significantly increased, the TXB2 level decreased (P < 0.05) and the TXB2 /6-keto-PGF1alpha ratio also decreased (P < 0.01) in the medicinal cake-separated moxibustion group as compared with those in the model group respectively, but there was no significant difference between the medicinal cake-separated moxibustion group and the direct moxibustion group (P > 0.05), suggesting that both the medicinal cake-separated moxibustion and direct moxibustion can regulate the plasma 6-keto-PGF1alpha and TXB2 contents, and the TXB2/6-keto-PGF1alpha ratio with similar actions, and have a certain protective action on endothelial cells of the aorta in the rabbit of hyperlipemia.
A practical guide to external cardiac pacing (2008)

External (transcutaneous) pacing is a temporary means of pacing a patient's heart during an emergency. Pulses of electrical current are delivered through the patient's chest to stimulate the cardiac muscle to contract. It restores electrical stimulation to the myocardium in an emergency setting and its advantage is that it can be initiated quickly by any healthcare professional who has undertaken the necessary training. This article provides the reader with a greater understanding of external pacing by exploring some of the theoretical and practical issues associated with the procedure.
Dynamic Kinetic Resolutions Catalyzed by a Planar-Chiral Derivative of DMAP:  Enantioselective Synthesis of Protected α-Amino Acids from Racemic Azlactones (1998)

ADVERTISEMENT RETURN TO ISSUECommunicationNEXTDynamic Kinetic Resolutions Catalyzed by a Planar-Chiral Derivative of DMAP: Enantioselective Synthesis of Protected α-Amino Acids from Racemic AzlactonesJack Liang, J. Craig Ruble, and Gregory C. FuView Author Information Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Cite this: J. Org. Chem. 1998, 63, 10, 3154–3155Publication Date (Web):April 16, 1998Publication History Received25 February 1998Published online16 April 1998Published inissue 1 May 1998https://pubs.acs.org/doi/10.1021/jo9803380https://doi.org/10.1021/jo9803380rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views3315Altmetric-Citations144LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Catalysts,Dynamic kinetic resolution,Reaction products,Stereoselectivity Get e-Alerts
The Process of Designing Appropriate Smart Homes: Including the User in the Design (2001)

Information and Communication Technology (ICT) has recently been relocated from an external entity brought into the home, to an internal feature of the domestic environment extending the range of the home beyond the ‘bricks and mortar’. Whilst other European countries such as Germany and Sweden have embraced the technology for its environmental and functional properties, the UK has been slow to adopt smart home technology except as a toy for the rich and famous. A number of research projects have considered the use of smart home technology within a range of social spheres, demonstrating the technology for a wide range of people with differing levels of disabilities and older people whilst developing a software suite that enables people to design smart homes that reflect people’s needs. Smart homes can be useful; enhancing the quality of life for people whose life is limited by their domestic environment. This paper seeks to consider how smart home technology can be incorporated appropriately within the design process, exploring the difficulties in determining the most appropriate type of technology to meet the needs of people. The paper concludes with a set of guidelines to inform future designs within this area.
Raji-K562 hybrids and their use for trioma production. (1988)

Cells from the B lymphoblastoid cell line Raji (Burkitt lymphoma) and from the myeloid-erythroid cell line K562 (subline AB5), stained by two different fluorochromes, were fused in vitro by means of PEG. Hybrid cells exhibiting heterofluorescence were isolated in a cell sorter (FACS III). They were cloned and analyzed for both Raji and K562 derived antigens. Hybrid cells retained the excellent growth behaviour of AB5 cells while expressing also Raji antigens. One of the hybrids (BD7) was used for trioma production when fused with human stimulated spleen cells. Trioma cells representing a fusion product of three parental cells may be useful for studying problems of gene regulation and expression.
70.20 Which is bigger— e π or π e (1986)

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Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism (1991)

Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) neurons by inhibiting monoamine oxidase B necessary to mediate the conversion of MPTP to MPP+, its active metabolite, in astroglia. Mice were pretreated with saline or the PD-producing toxin, MPTP (30 mg/kg) daily for 5 days and then after a further 3 days (to allow for the metabolism and excretion of the MPTP) were treated with deprenyl (0.25 or 10 mg/kg) or saline 3 times weekly for 20 days. In three series of mice treated with MPTP alone or MPTP-saline, serial sections through the SNc showed that averages of 37-42% of tyrosine hydroxylase (TH) immunoreactive neurons were lost gradually over 20 days. Joint counts of the numbers of TH-immunoreactive and Nissl-stained SNc somata from immediately adjacent sections established that the reductions in the numbers of TH-immunoreactive somata at 20 days after MPTP treatment represented neuronal death. Deprenyl treatment reduced the loss of TH-immunoreactive SNc neurons to averages of 14-16% for the 10-mg/kg and 0.25-mg/kg doses, respectively, and joint Nissl/TH counts for adjacent sections showed that reduction in the loss of TH-immunoreactive soma represented the rescue of SNc neurons that would have died by 20 days. The gradual loss of SNc neurons over the 20 days following MPTP exposure may reflect the toxin's axotomy-like effects on SNc neurons or the prolonged action of sequestered MPP+.(ABSTRACT TRUNCATED AT 250 WORDS)
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo (2015)

The high-grade pulmonary neuroendocrine tumors, small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC), remain among the most deadly malignancies. Therapies that effectively target and kill tumor-initiating cells (TICs) in these cancers should translate to improved patient survival. Patient-derived xenograft (PDX) tumors serve as excellent models to study tumor biology and characterize TICs. Increased expression of delta-like 3 (DLL3) was discovered in SCLC and LCNEC PDX tumors and confirmed in primary SCLC and LCNEC tumors. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues. A DLL3-targeted antibody-drug conjugate (ADC), SC16LD6.5, comprised of a humanized anti-DLL3 monoclonal antibody conjugated to a DNA-damaging pyrrolobenzodiazepine (PBD) dimer toxin, induced durable tumor regression in vivo across multiple PDX models. Serial transplantation experiments executed with limiting dilutions of cells provided functional evidence confirming that the lack of tumor recurrence after SC16LD6.5 exposure resulted from effective targeting of DLL3-expressing TICs. In vivo efficacy correlated with DLL3 expression, and responses were observed in PDX models initiated from patients with both limited and extensive-stage disease and were independent of their sensitivity to standard-of-care chemotherapy regimens. SC16LD6.5 effectively targets and eradicates DLL3-expressing TICs in SCLC and LCNEC PDX tumors and is a promising first-in-class ADC for the treatment of high-grade pulmonary neuroendocrine tumors.
Progressive Trust Formation within the South African Fresh Produce Industry through the use of Self-Service Technologies (2015)

When using self-service solutions to deliver services, the challenge is to retain the trust of the end user.&#13;\nThis is specifically the case when dealing with end users in the fresh produce market environment. This&#13;\nsector has not seen the adoption of self-service technologies, specifically in southern Africa. In this&#13;\npaper we propose a model to enhance our understanding of trust formation using self-service&#13;\ntechnologies. A qualitative research approach based on a case study was followed to create the model.&#13;\nThis case study offers insight into how the dynamics of the product, supporting services, and the&#13;\ntechnology shapes trust forming behavior.
Improved iterative error analysis for endmember extraction from hyperspectral imagery (2008)

Automated image endmember extraction from hyperspectral imagery is a challenge and a critical step in spectral mixture analysis (SMA). Over the past years, great efforts were made and a large number of algorithms have been proposed to address this issue. Iterative error analysis (IEA) is one of the well-known existing endmember extraction methods. IEA identifies pixel spectra as a number of image endmembers by an iterative process. In each of the iterations, a fully constrained (abundance nonnegativity and abundance sum-to-one constraints) spectral unmixing based on previously identified endmembers is performed to model all image pixels. The pixel spectrum with the largest residual error is then selected as a new image endmember. This paper proposes an updated version of IEA by making improvements on three aspects of the method. First, fully constrained spectral unmixing is replaced by a weakly constrained (abundance nonnegativity and abundance sum-less-or-equal-to-one constraints) alternative. This is necessary due to the fact that only a subset of endmembers exhibit in a hyperspectral image have been extracted up to an intermediate iteration and the abundance sum-to-one constraint is invalid at the moment. Second, the search strategy for achieving an optimal set of image endmembers is changed from sequential forward selection (SFS) to sequential forward floating selection (SFFS) to reduce the so-called "nesting effect" in resultant set of endmembers. Third, a pixel spectrum is identified as a new image endmember depending on both its spectral extremity in the feature hyperspace of a dataset and its capacity to characterize other mixed pixels. This is achieved by evaluating a set of extracted endmembers using a criterion function, which is consisted of the mean and standard deviation of residual error image. Preliminary comparison between the image endmembers extracted using improved and original IEA are conducted based on an airborne visible infrared imaging spectrometer (AVIRIS) dataset acquired over Cuprite mining district, Nevada, USA.
Oral Sildenafil in the Treatment of Erectile Dysfunction (1998)

Oral sildenafil is an effective, well-tolerated treatment for men with erectile dysfunction.
Genomic and functional conservation of sedative-hypnotic targets in the zebrafish (2007)

These results demonstrate conservation of gene, protein and function for many established sedative hypnotic pathways. The results indicate feasibility of conducting large-scale pharmacogenomic screens to isolate novel proteins modulating susceptibility to hypnotic compounds in a vertebrate system.
Rescue and replication of adeno-associated virus type 2 as well as vector DNA sequences from recombinant plasmids containing deletions in the viral inverted terminal repeats: selective encapsidation of viral genomes in progeny virions (1996)

The adeno-associated virus type 2 (AAV) genome can be successfully rescued from recombinant plasmids following transfection in adenovirus-infected human cells. However, following rescue, the AAV genome undergoes preferential replication and encapsidation, whereas little replication and packaging of the vector DNA sequences occur. In view of the crucial role in the rescue, replication, and packaging of the proviral genome played by the AAV inverted terminal repeats (ITRs), which consist of a palindromic hairpin (HP) structure and a 20-nucleotide stretch, designated the D-sequence, that is not involved in the HP-formation, we evaluated the involvement of the individual ITRs as well as their components in the selective viral DNA replication and encapsidation. A number of recombinant AAV plasmids that contained deletions-substitutions in different regions of the individual ITRs were constructed and examined for their potential to allow rescue, replication, and/or packaging in adenovirus-infected human cells in vivo. The results reported here document that (ii) two HP structures and one D-sequence are sufficient for efficient rescue and preferential replication of the AAV DNA, (ii) two HP structures alone allow a low-level rescue and replication of the AAV DNA, but rescue and replication of the vector DNA sequences also occur in the absence of the D-sequences, (iii) one HP structure and two D-sequences, but not one HP structure and one D-sequence, also allow rescue and replication of the AAV as well as the vector DNA sequences, (iv) one HP structure alone or two D-sequences, but not one D-sequence alone, allow replication of the full-length plasmid DNA, but no rescue of the AAV genome occurs, (v) no rescue-replication occurs in the absence of the HP structures and the D-sequences, (vi) in the absence of the D-sequences, the HP structures are insufficient for successful encapsidation of the AAV genomes, and (vii) the AAV genomes containing only one ITR structure can be packaged into biologically active virions. Thus, the D-sequence plays a crucial role in the efficient rescue and selective replication and encapsidation of the AAV genome. Furthermore, the D-sequence specifically interacts with a hitherto unknown host-cell protein that we have designated the D-sequence-binding protein (D-BP). These studies illustrate that the D-sequence-D-BP interaction constitutes an important step in the AAV life cycle.
Thermal Neutron Scintillator Detectors Based on Poly (2-Vinylnaphthalene) Composite Films (2011)

A series of novel <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> Li-loaded plastic scintillation films have been designed and fabricated to detect thermal neutrons. Organolithium salts containing enriched <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> Li were synthesized and interspersed in a series of matrices comprising a polymer doped with an antenna fluor. Thermal neutron capture by <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sup> Li produces charged particles with kinetic energy which is sufficient to ionize and excite the polymeric matrix. This energy is collected by the antenna fluor, which produces a photonic response detectable by a photomultiplier tube. Design and optimization of these scintillation films is discussed herein. A current problem in the design and fabrication of polymeric composite materials is phase separation. The matrix is a low-dielectric aromatic polymer; hence, ionic molecules in the composite tend to phase-separate from the matrix and produce agglomerates which decrease the quantum efficiency by scattering and/or quenching the photonic response to thermal neutrons. Based on the experimental results, the importance of synthesizing polymers with high quantum yield and efficiency in energy migration and transport for making effective composite neutron scintillators is emphasized.
Concentrations of serotonin in plasma--a test for appendicitis? (1988)

We assessed the value of measuring serotonin (5-hydroxytryptamine) in plasma (by HPLC) in the diagnosis of acute appendicitis. Values for patients with subsequently confirmed appendicitis (11-145 nmol/L, median 70 nmol/L) significantly (P congruent to 0.005) exceeded those for patients with abdominal pain in whom appendicitis was only a possible diagnosis (2-45 nmol/L, median 20 nmol/L). The results for appendicitis patients were bimodally distributed, with low results found in patients where surgery revealed gangrenous appendicitis with little viable appendicular tissue. We conclude that measuring serotonin may be of value in confirming or excluding the diagnosis of early acute appendicitis where the physical signs are equivocal, and thus helps reduce unnecessary appendectomies. However, serotonin is of little help in diagnosing gangrenous appendicitis, where physical signs are more likely to be clearcut.
Advanced methods for I/Q imbalance compensation in communication receivers (2001)

I/Q signal processing is widely utilized in today's communication receivers. However, all I/Q processing receiver structures, such as the low-IF receiver, face a common problem of matching the amplitudes and phases of the I and Q branches. In practice, imbalances are unavoidable in the analog front-end, which results in finite and usually insufficient rejection of the image frequency band. This causes the image signal to appear as interference on top of the desired signal. We carry out general signal analysis of an imbalanced I/Q processing receiver and propose novel methods for I/Q imbalance compensation using baseband digital signal processing. A simple structure for compensation is derived, based on a traditional adaptive interference canceller. Improved image rejection can also be obtained by using more advanced blind source separation techniques. Theoretical analysis of the performance of the proposed imbalance compensation structures is presented. In addition, some simulation results are provided in order to further evaluate the performance of the proposed methods. The results indicate that the I/Q imbalance can be effectively compensated during the normal operation of the receiver even in the rapidly changing case, as long as a linear system model for the imbalance is valid.
Gametophytic Self-Incompatibility Reexamined (1983)

The conventional hypothesis of gametophytic self-incompatibility in the angiosperms involves one to four multiallelic incompatibility loci and the positive inhibition of incompatible pollen tubes. However, this concept does not accommodate recent experimental data indicating that there may be many loci. An alternative hypothesis which incorporates many loci and complementary pollen-style interactions suggests that there may be no S gene, as previously thought, and that gametophytic self-incompatibility is perhaps merely one aspect of extensive pollen-style interactions.
Effect of pH on Hemoglobin-Catalyzed Lipid Oxidation in Cod Muscle Membranes in Vitro and in Situ (2005)

The effect of pH and hemoglobin on oxidation of the microsomal lipids of cod was determined in isolated microsomes and in washed cod muscle. An increase of hemoglobin concentration from 0.5 to 15 microM accelerated lipid oxidation in both systems. In cod microsomes the rate of lipid oxidation increased in the order pH 6.8 >> pH 7.6 > pH 8.4 > pH 6.0 > pH 3.5. However, in washed cod muscle a decrease of pH from 7.8 to 6.8 greatly increased the lag phase and decreased the rate of lipid oxidation. A further decrease in pH to 3.5 decreased the lag phase and increased the rate of lipid oxidation further. A decrease of pH from 7.6 to 6.4 greatly reduced the affinity of hemoglobin for oxygen. Formation of methemoglobin due to autoxidation occurred more rapidly at pH 6.0 than at pH 7.5. Structural changes of the isolated microsomal membranes could be the reason for the unexpected slow lipid oxidation in microsomes at pH 6.0 and below.
Ranking refinement and its application to information retrieval (2008)

We consider the problem of ranking refinement, i.e., to improve the accuracy of an existing ranking function with a small set of labeled instances. We are, particularly, interested in learning a better ranking function using two complementary sources of information, ranking information given by the existing ranking function (i.e., a base ranker) and that obtained from users' feedbacks. This problem is very important in information retrieval where the feedback is gradually collected. The key challenge in combining the two sources of information arises from the fact that the ranking information presented by the base ranker tends to be imperfect and the ranking information obtained from users' feedbacks tends to be noisy. We present a novel boosting framework for ranking refinement that can effectively leverage the uses of the two sources of information. Our empirical study shows that the proposed algorithm is effective for ranking refinement, and furthermore significantly outperforms the baseline algorithms that incorporate the outputs from the base ranker as an additional feature.
DNA Is Taken Up by Root Hairs and Pollen, and Stimulates Root and Pollen Tube Growth (2010)

Phosphorus (P) enters roots as inorganic phosphate (P(i)) derived from organic and inorganic P compounds in the soil. Nucleic acids can support plant growth as the sole source of P in axenic culture but are thought to be converted into P(i) by plant-derived nucleases and phosphatases prior to uptake. Here, we show that a nuclease-resistant analog of DNA is taken up by plant cells. Fluorescently labeled S-DNA of 25 bp, which is protected against enzymatic breakdown by its phosphorothioate backbone, was taken up and detected in root cells including root hairs and pollen tubes. These results indicate that current views of plant P acquisition may have to be revised to include uptake of DNA into cells. We further show that addition of DNA to P(i)-containing growth medium enhanced the growth of lateral roots and root hairs even though plants were P replete and had similar biomass as plants supplied with P(i) only. Exogenously supplied DNA increased length growth of pollen tubes, which were studied because they have similar elongated and polarized growth as root hairs. Our results indicate that DNA is not only taken up and used as a P source by plants, but ironically and independent of P(i) supply, DNA also induces morphological changes in roots similar to those observed with P limitation. This study provides, to our knowledge, first evidence that exogenous DNA could act nonspecifically as signaling molecules for root development.