gebhart/patrepeval huggingface dataset:
Quaternion-Based Kalman Filter With Vector Selection for Accurate Orientation Tracking (2012)

Human body orientation estimation from microinertial/magnetic sensor units is highly important for synthetic environments, robotics, and other human-computer interaction applications. In practice, the main challenge is how to deal with linear acceleration interference and magnetic disturbance which always cause significant attitude-estimation errors. In this paper, we present a novel quaternion-based Kalman filter with vector selection scheme for accurate human body orientation estimation using an inertial/magnetic sensor unit. In the proposed algorithm, the gyroscope measurement is used as an input to construct the linear process equation, and the accelerometer and magnetometer measurements are manipulated to establish the linear pseudomeasurement equation. A linear Kalman filter is then deployed to estimate the body orientation. In the Kalman filter framework, a vector selection scheme is designed to protect the algorithm against undesirable conditions such as temporary intensive movement and magnetic disturbance and enable it to acquire more accurate orientation estimation. The experimental results have shown that the proposed algorithm can provide accurate attitude estimations with regard to the ground truth.
The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression (1996)

Hypoxia-inducible factor-1 (HIF-1), a DNA-binding complex implicated in the regulation of gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1alpha, and HIF-1beta. One partner, HIF-1beta, had been recognized previously as the aryl hydrocarbon receptor nuclear translocator (ARNT), an essential component of the xenobiotic response. In the present work, ARNT-deficient mutant cells, originally derived from the mouse hepatoma line Hepa1c1c7, have been used to analyze the role of ARNT/HIF-1beta in oxygen-regulated gene expression. Two stimuli were examined: hypoxia itself and desferrioxamine, an iron-chelating agent that also activates HIF-1. Induction of the DNA binding and transcriptional activity of HIF-1 was absent in the mutant cells, indicating an essential role for ARNT/HIF-1beta. Analysis of deleted ARNT/HIF-1beta genes indicated that the basic, helix-loop-helix, and PAS domains, but not the amino or carboxyl termini, were necessary for function in the response to hypoxia. Comparison of gene expression in wild type and mutant cells demonstrated the critical importance of ARNT/HIF-1beta in the hypoxic induction of a wide variety of genes. Nevertheless, for some genes a reduced response to hypoxia and desferrioxamine persisted in these mutant cells, clearly distinguishing ARNT/HIF-1beta-dependent and ARNT/HIF-1beta-independent mechanisms of gene activation by both these stimuli.
Novel Slow- and Fast-Type Drug Release Round-Window Microimplants for Local Drug Application to the Cochlea: An Experimental Study in Guinea Pigs (2004)

Novel drug release microimplants (0.8 x 1.14 mm; custom-made by Leiras, now Schering OY, Finland) of slow- and fast-release types containing either 0.9 mg beclomethasone or no drug at all were placed unilaterally onto the round-window membrane (RWM) of 45 guinea pigs for a maximum duration of 28 days. The following parameters were tested on days 1, 14 and 28 after implantation: threshold levels of beclomethasone in the perilymph of the scala tympani, auditory brain stem responses (ABR thresholds and ABR threshold shifts), RWM morphology and hair cell loss (cytocochleograms). None of the animals in the non-implanted control group (n = 5) or placebo implant group (n = 15), but all animals in the slow-release-type implant group (n = 15) and fast-release-type implant group (n = 15) revealed the presence of beclomethasone on day 1 (34.9 and 64.3 pg/microl, respectively), day 14 (43.8 and 46.9 pg/microl, respectively) and day 28 after implantation (4.7 and 60.5 pg/microl, respectively). Histology of the RWMs appeared normal, and cytocochleograms revealed no inner hair cell loss and outer hair cell loss within normal ranges (from 0.5 +/- 0.4 to 0.8 +/- 0.2% per cochlea) in both ears in all experimental groups at any time during examination (days 1, 14 and 28). Initial values of ABR thresholds at 3, 6, 9 and 12 kHz did not differ significantly in any of the experimental groups. In non-implanted controls, no significant differences of ABR thresholds were observed in all frequencies tested in either ear on days 1, 14 and 28 compared to initial values, and ABR threshold shifts ranged from -3 +/- 5 dB (min.) to +5 +/- 7 dB (max.). On day 28 after implantation, there were no significant differences of ABR threshold shifts between this and the implant groups, except for 6 kHz of the slow-release device. Therefore, the placebo implants, the slow-release and the fast-release beclomethasone implants appear suitable for further experiments.
Australia and the Global Financial Crisis: A Highly Efficient Policy Response at the Cost of Locking in Structural Imbalances (2010)

This paper was prepared for the October 2010 LINK Conference. Indicators of the structural vulnerability of the Australian economy are examined, and the Australian fiscal policy stimulus measures and the outcomes for Australia are discussed. A quantitative assessment is undertaken to measure the impact of the fiscal response. This paper has two objectives. The first is to explain the reasons for the Australian outcome and the effective policy response. The second objective is to document the reasons why a stand-alone crisis for the Australian economy can be expected over the next decade and probably within the next 5 years, commencing in 2013 or thereabouts.
Effect of heat and sodium dodecyl sulfate on solubilization of proteins before two-dimensional polyacrylamide gel electrophoresis. (1984)

To solubilize biological samples, sodium dodecyl sulfate (SDS) frequently is added and the mixture heated at 70-100 degrees C. However, two-dimensional polyacrylamide gel electrophoresis of a single protein after SDS treatment has not been reported. When rabbit-muscle creatine kinase was so run, we saw considerable difference in the gel staining pattern for the heated and nonheated enzyme dissolved in the SDS solution. After heating for 10 min at 95 degrees C the number of silver-stained spots apparent increased, and staining of several spots intensified. After 60 min, most of the discrete spots disappeared. Evidently the peptide backbone had been hydrolyzed. When the enzyme was simply left at room temperature for four days, the effects were similar. Appearance of new spots and loss of spots apparently are caused by heating alone but are intensified by SDS. Experiments with human serum albumin yielded similar results.
Robust Visual Inertial Odometry Using a Direct EKF-Based Approach (2015)

In this paper, we present a monocular visual-inertial odometry algorithm which, by directly using pixel intensity errors of image patches, achieves accurate tracking performance while exhibiting a very high level of robustness. After detection, the tracking of the multilevel patch features is closely coupled to the underlying extended Kalman filter (EKF) by directly using the intensity errors as innovation term during the update step. We follow a purely robocentric approach where the location of 3D landmarks are always estimated with respect to the current camera pose. Furthermore, we decompose landmark positions into a bearing vector and a distance parametrization whereby we employ a minimal representation of differences on a corresponding σ-Algebra in order to achieve better consistency and to improve the computational performance. Due to the robocentric, inverse-distance landmark parametrization, the framework does not require any initialization procedure, leading to a truly power-up-and-go state estimation system. The presented approach is successfully evaluated in a set of highly dynamic hand-held experiments as well as directly employed in the control loop of a multirotor unmanned aerial vehicle (UAV).
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD) (2007)

The immunomodulator FTY720 (FTY) has been shown to be beneficial in experimental models of organ transplantation and autoimmunity. We show that FTY significantly inhibited but did not prevent graft-versus-host disease (GVHD) in lethally irradiated or nonirradiated allogeneic recipients. Although most studies implicate prevention of lymphocyte egress from lymphoid organs as the primary mechanism of action, our data indicate that FTY effects on the host are more likely to be responsible for GVHD inhibition. FTY reduced splenic CD11c+ cells by 50%, and similarly reduced CD4+ and CD8+ T-cell responder frequencies in the spleen early after transplantation. Imaging of GFP+ effectors indicated that FTY modified donor effector T-cell migration to secondary lymphoid organs, but did not uniformly trap T cells in lymph nodes or prevent early effector migration to GVHD parenchymal target organs. Administration of FTY only prior to transplantation inhibited GVHD, indicating that the primary function of FTY may be targeted to host cells. FTY was additive with regulatory T cells for GVHD inhibition. FTY slightly impaired but did not abrogate a graft-versus-leukemia (GVL) effect against C1498, a myeloid leukemia. Our data further define the mechanisms of action and provide insight as to the potential clinical uses of FTY in allogeneic bone marrow transplant recipients.
Tumor lymphangiogenesis and metastatic spread—New players begin to emerge (2006)

The metastatic spread of tumor cells is the most lethal aspect of cancer and can occur via various routes, including the lymphatic vasculature. Studies of tumor models in animals and clinicopathological data have indicated that growth of lymphatic vessels (lymphangiogenesis) in the vicinity of solid tumors may contribute to lymphatic metastasis. Research over the past 5 years has identified a range of lymphangiogenic growth factors that could conceivably play a role in promoting tumor lymphangiogenesis and lymphatic metastasis. The most extensively studied signaling system that promotes lymphangiogenesis in tumors involves the secreted lymphangiogenic proteins vascular endothelial growth factor-C (VEGF-C) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor-3 (VEGFR-3). More recent studies have identified other signaling molecules that can also promote lymphangiogenesis in vivo, including hepatocyte growth factor and members of the fibroblast growth factor, angiopoietin, platelet-derived growth factor and insulin-like growth factor families of secreted proteins. This article provides an overview of the molecular mechanisms that control lymphangiogenic signaling, emphasizing the more recently identified lymphangiogenic growth factors and the roles they may play in cancer biology. Molecular approaches for inhibiting lymphangiogenic signaling in cancer, designed to restrict tumor metastasis, are also examined.
Structure And Evolution Of Calcium-Modulated Protein (1980)

This review suggests that the intracellular functions of calcium are best understood in terms of calcium's functioning as a second messenger. Further, when functioning as a second messenger, calcium completes its mission not by transferring charge nor by binding to lipid but by binding to specific targets, calcium-modulated proteins. This concept is broadly interpreted to include proteins involved in calcium transport. There is strong evidence that many, if not all, of these calcium-modulated proteins are homologs. Their structures and properties are contrasted to those of extracellular calcium-binding proteins which are not homologous to one another or to the intracellular calcium-modulated proteins. Finally, this line of thought leads to a suggestion of the evolutionary reason for the choice of calcium as the sole inorganic second messenger.
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. (1994)

The promoter of the murine gene encoding inducible nitric oxide synthase (iNOS) contains an NF-kappa B site beginning 55 base pairs upstream of the TATA box, designated NF-kappa Bd. Reporter constructs containing truncated promoter regions, when transfected into macrophages, revealed that NF-kappa Bd is necessary to confer inducibility by bacterial lipopolysaccharide (LPS). Oligonucleotide probes containing NF-kappa Bd plus the downstream 9 or 47 base pairs bound proteins that rapidly appeared in the nuclei of LPS-treated macrophages. The nuclear proteins bound to both probes in an NF-kappa Bd-dependent manner, but binding was resistant to cycloheximide only for the shorter probe. The proteins binding both probes reacted with antibodies against p50 and c-rel but not RelB; those binding the shorter probe also reacted with anti-RelA (p65). Pyrrolidine dithiocarbamate, which acts as a specific inhibitor of NF-kappa B, blocked both the activation of the NF-kappa Bd-binding proteins and the production of NO in LPS-treated macrophages. Thus, activation of NF-kappa B/Rel is critical in the induction of iNOS by LPS. However, additional, newly synthesized proteins contribute to the NF-kappa Bd-dependent transcription factor complex on the iNOS promoter in LPS-treated mouse macrophages.
Content Centric Networking in tactical and emergency MANETs (2010)

Reliable and secure content distribution in a disruptive environment is a critical challenge due to high mobile and lossy channels. Traditional IP networking and wireless protocols tend to perform poorly. In this paper, we propose Content Centric Networking (CCN) for emergency wireless ad hoc environments. CCN is a novel communication architecture capable to access and retrieve content by name. This new approach achieves scalability, security, and efficient network resource management in large scale disaster recovery and battlefield networks. Existing Internet CCN schemes cannot be directly applied to wireless mobile ad hoc networks due to different environments and specific limitations. Thus, we must extend the CCN architecture by introducing features and requirements especially designed for disruptive networks. We prove feasibility and performance gain of the new design via implementation and experimentation.
Particulate Matter Air Pollution and Cardiovascular Disease (2010)

In 2004, the first American Heart Association scientific statement on "Air Pollution and Cardiovascular Disease" concluded that exposure to particulate matter (PM) air pollution contributes to cardiovascular morbidity and mortality. In the interim, numerous studies have expanded our understanding of this association and further elucidated the physiological and molecular mechanisms involved. The main objective of this updated American Heart Association scientific statement is to provide a comprehensive review of the new evidence linking PM exposure with cardiovascular disease, with a specific focus on highlighting the clinical implications for researchers and healthcare providers. The writing group also sought to provide expert consensus opinions on many aspects of the current state of science and updated suggestions for areas of future research. On the basis of the findings of this review, several new conclusions were reached, including the following: Exposure to PM <2.5 microm in diameter (PM(2.5)) over a few hours to weeks can trigger cardiovascular disease-related mortality and nonfatal events; longer-term exposure (eg, a few years) increases the risk for cardiovascular mortality to an even greater extent than exposures over a few days and reduces life expectancy within more highly exposed segments of the population by several months to a few years; reductions in PM levels are associated with decreases in cardiovascular mortality within a time frame as short as a few years; and many credible pathological mechanisms have been elucidated that lend biological plausibility to these findings. It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM(2.5) exposure and cardiovascular morbidity and mortality. This body of evidence has grown and been strengthened substantially since the first American Heart Association scientific statement was published. Finally, PM(2.5) exposure is deemed a modifiable factor that contributes to cardiovascular morbidity and mortality.
REVIEW OF MECHANICAL PROPERTIES OF OIL SHALES: IMPLICATIONS FOR EXPLOITATION AND BASIN MODELLING (2007)

Mechanical properties of oil shales as a function of temperature and pressure are reviewed.Implications of evolution of these properties for in situ exploitation and basin modelling are explored.Mechanical properties at room temperature are well known.The existing data suggest a positive correlation between oil shale grade (organic matter content) and Poisson ratio, whereas tensile and compressive strength as well as modulus of elasticity show negative correlations.These properties are strongly affected by temperature.An increase in temperature results in loss of strength and decrease in Young's modulus.Strength follows a logarithmic decrease with increasing temperature, depending on grade.Creep is much enhanced by elevated temperature.Extrapolation of laboratory data to nature suggests that tensile fracturing may occur more easily during petroleum generation, and creep is more prominent in oil shales than in other rocks at this depth in the crust.More high-temperature experiments are required to validate these conclusions.
Scanning Probe Lithography Using Self-Assembled Monolayers (2003)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTScanning Probe Lithography Using Self-Assembled MonolayersStephan Krämer, Ryan R. Fuierer, and Christopher B. GormanView Author Information Department of Chemistry, North Carolina State University, Box 8204, Raleigh, North Carolina 27695-8204 Cite this: Chem. Rev. 2003, 103, 11, 4367–4418Publication Date (Web):October 1, 2003Publication History Received9 April 2003Published online1 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/cr020704mhttps://doi.org/10.1021/cr020704mresearch-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views4646Altmetric-Citations386LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Gold,Lithography,Molecules,Scanning tunneling microscopy,Silicon Get e-Alerts
Properties of polyisobutylene‐polyurethane block copolymers: I. Macroglycols from ozonolysis of isobutylene‐isoprene copolymer (1983)

Abstract The properties of a series of polyisobutylene (PIB) based polyurethanes were studied and compared to those reported in the literature for polyether, polyester, and polybutadiene‐based polyurethanes. Good phase separation was reflected in the invariance of the soft segment T n with increasing hard segment content. Increasing hard segment content resulted in larger domains, higher modulus and lower ultimate elongation. The modulus above the soft segment T n was higher than that previously reported for polyurethanes of similar hard segment contant; improved phase separation and short contour lengths of the PIB chains were cited as possible causes of this behavior. Stress‐strain data indicated a change from isolated to interconnected domain morphology with incerasing hard segment contant. Generally similar trends were seen for all types of urethanes. The overall properties of polybutadiene polyurethanes were closest to those of the polyisobutylene polyurethanes studied. The properties of both of these systems were suggested to suffer from significant synthesis problems in urethane formation due to the incompatibility of the nonpolar hydrocarbon soft segment and the polar diol chain extender. Preliminary environmental tests indicated that polyisobutylene based materials exhibit improved hydrolytic stability and reduced moisture permeability compared to polyether and polyester polyurethanes and greater oxidative stability compared to polybutadiene based materials.
Inhibition of Protein Tyrosine Phosphorylation in T Cells by a Novel Immunosuppressive Agent, Leflunomide (1995)

Leflunomide, a novel immunosuppressive drug, is able to prevent and reverse allograft and xenograft rejection in rodents, dogs, and monkeys. It is also effective in the treatment of several rodent models of arthritis and autoimmune disease. In vitro studies indicate that leflunomide is capable of inhibiting anti-CD3- and interleukin-2 (IL-2)-stimulated T cell proliferation. However, the biochemical mechanism for the inhibitory activity of leflunomide has not been elucidated. In this study, we characterized the inhibitory effects of leflunomide on Src family (p56lck and p59fyn)-mediated protein tyrosine phosphorylation. Leflunomide was able to inhibit p59fyn and p56lck activity in in vitro tyrosine kinase assays. The IC50 values for p59fyn (immunoprecipitated from either Jurkat or CTLL-4 cell lysate) autophosphorylation and phosphorylation of the exogenous substrate, histone 2B, were 125-175 and 22-40 microM respectively, while the IC50 values for p56lck (immunoprecipitated from Jurkat cell lysates) autophosphorylation and phosphorylation of histone 2B were 160 and 65 microM respectively. We also demonstrated the ability of leflunomide to inhibit protein tyrosine phosphorylation induced by anti-CD3 monoclonal antibody in Jurkat cells. The IC50 values for total intracellular tyrosine phosphorylation ranged from 5 to 45 microM, with the IC50 values for the zeta chain and phospholipase C isoform gamma 1 being 35 and 44 microM respectively. Leflunomide also inhibited Ca2+ mobilization in Jurkat cells stimulated by anti-CD3 antibody but not in those stimulated by ionomycin. Distal events of anti-CD3 monoclonal antibody stimulation, namely, IL-2 production and IL-2 receptor expression on human T lymphocytes, were also inhibited by leflunomide. Finally, tyrosine phosphorylation in CTLL-4 cells stimulated by IL-2 was also inhibited by leflunomide. These data collectively demonstrate the ability of leflunomide to inhibit tyrosine kinase activity in vitro, and suggest that inhibition of tyrosine phosphorylation events may be the mechanism by which leflunomide functions as an immunosuppressive agent.