gebhart/patrepeval huggingface dataset:
Serum amyloid A and high‐density lipoprotein cholesterol: serum markers of inflammation in sarcoidosis and other systemic disorders (2001)

Hypocholesterolemia has been observed in several inflammatory diseases such as rheumatoid arthritis, myeloproliferative disorders, systemic lupus erythematosus and sarcoidosis. Serum amyloid A is an acute-phase reactant that is related to the high-density lipoprotein cholesterol. This review discusses the relationship between the activation of the cells of the monocyte-macrophage system, determined by the serum amyloid A levels, and the lipid metabolism, measured as alterations in plasma lipoprotein concentrations. The mechanisms of this association during acute inflammation are also discussed in this review.
Mapping Hydraulic Fracture Growth and Geometry Using Microseismic Events Detected by a Wireline Retrievable Accelerometer Array (1998)

Abstract Technology has advanced to the point where microseismic monitoring of hydraulic fractures can provide critical information for fracture optimization. Important elements of a monitoring system include the receivers, the telemetry system, and automatic processing of the vast amounts of - data. Procedures and additional data requirements are discussed and examples of the important results which can be obtained are illustrated. P. 335
Comparative Genomics of Gene Expression in the Parasitic and Free-Living Nematodes Strongyloides stercoralis and Caenorhabditis elegans (2004)

Although developmental timing of gene expression is used to infer potential gene function, studies have yet to correlate this information between species. We analyzed 10,921 ESTs in 3311 clusters from first- and infective third-stage larva (L1, L3i) of the parasitic nematode Strongyloides stercoralis and compared the results to Caenorhabditis elegans, a species that has an L3i-like dauer stage. In the comparison of S. stercoralis clusters with stage-specific expression to C. elegans homologs expressed in either dauer or nondauer stages, matches between S. stercoralis L1 and C. elegans nondauer-expressed genes dominated, suggesting conservation in the repertoire of genes expressed during growth in nutrient-rich conditions. For example, S. stercoralis collagen transcripts were abundant in L1 but not L3i, a pattern consistent with C. elegans collagens. Although a greater proportion of S. stercoralis L3i than L1 genes have homologs among the C. elegans dauer-specific transcripts, we did not uncover evidence of a robust conserved L3i/dauer 'expression signature.' Strikingly, in comparisons of S. stercoralis clusters to C. elegans homologs with RNAi knockouts, those with significant L1-specific expression were more than twice as likely as L3i-specific clusters to match genes with phenotypes. We also provide functional classifications of S. stercoralis clusters.
Hypergranulation tissue: a nontraumatic method of management. (1994)

Granulation tissue above the periwound area is usually considered an impediment to wound healing. Although there is very little in the literature regarding hypergranulation tissue, the fact that there are numerous treatments by various wound clinicians demonstrates the recognition of its presence as a clinical problem. The paucity of published information prompted the authors to design a study to collect objective data on a treatment method they had found useful in their practices. This article explores the issue of hypergranulation and offers a nontraumatic method of management. A prospective non-controlled correlational study was undertaken with ten patients and twelve wounds using a polyurethane foam dressing to reduce hypergranulation tissue. The results demonstrated a significant decrease in height of 2 mm of granulation tissue from initial measurements to measurements taken two weeks later (p < 0.01).
Surface reaction probability in hydrogenated amorphous silicon growth (1994)

We deposit hydrogenated amorphous silicon (a-Si:H) on a novel ‘‘macroscopic’’ trench substrate using both remote hollow cathode (HC) silane discharges and reactive magnetron sputter (RMS) deposition sources. Both methods produce state of the art optoelectronic quality a-Si:H. We analyze the surface coverage profiles in terms of the surface reaction probability β, using a Monte Carlo simulation to correct for particle reflection and loss. We also measure the deposited film quality as a function of position in the trench. For low power silane HC deposition, we find β=0.28±0.05, whereas for the RMS case β=0.97±0.05. In contrast to the prevailing thinking in the a-Si:H field, this result demonstrates that β is not universally correlated with film quality. We discuss the role of energetic particle bombardment in RMS that permits high quality films to be deposited despite the high precursor reactivity.
[Rotational and vibrational state distributions of CsH in the reactions of Cs(6 2D5/2) with H2]. (2010)

The nascent quantum state distributions of the CsH product resulting from the reaction Cs(6D5/2) with Hz were determined using a laser pump-probe technique in a five-arm crossed heat-pipe oven. Cs-H2 mixture was irradiated with pulses of 885.4 nm radiation from a OPO laser, populating 6D5/2 state by two-photon absosption. Laser induced fluorescence was used to detect CsH molecules directly at the collision volume by scanning pulse tunable dye laser over X 1 sigma+ (v", J") --> A 1 sigma+ (v', J' = J" +/- 1) absorption line. The vibration bands (v" = 0, v' = 6) and (v" = 1, v' = 9) were chosen. For the investigated reaction, the nascent CsH product molecules were found to populate the lowest two vibrational (v" = 0, 1) levels of the ground electronic state but could not be detected in any higher vibrational state. Rotational distributions of CsH products obtained for v" = 0 and 1 states appear to be monomodal , peaking in J = 6-8. The rotational population profile is roughly consistent with a statistical distribution at the system temperature. A plot of logarithm of relative population of states J divided by the degeneracy factor (2J + 1) against J (J + 1) was yielded. The linearity of the plot establishes the Boltzmann form for rotational distributions of both the v" = 0 and 1. The rotational temperatures are (458 +/- 20) K and (447 +/- 18) K for v = 0 and 1, respectively. The nascent CsH rotational temperatures were found to be slightly below the cell temperature. The relative vibrational population was determined to be 0.527 and 0.473. The average vibrational and rotational energy release can be computed. The relative fractions (fv), (fR) and (fT) of average energy disposal were derived as 0.25, 0.10 and 0.65 respectively, having a major translation energy release. All of the above results support the assumption that the Cs(6 2D5/2)-H2 reaction occurs primarily in a collinear geometry by a harpoon mechanism but not an insertion.
Human demodicosis: revisit and a proposed classification (2014)

Human Demodex mites (Demodex folliculorum and Demodex brevis) hold a high rank in the evolutionary and phylogenetic hierarchy of the skin microbiome, although in most people their presence is of no consequence. While human demodicosis is a skin disease sui generis, it can mimic many other inflammatory dermatoses, such as folliculitis, rosacea and perioral dermatitis, leading to unspecific and confusing descriptions in the literature. Here, we propose to classify human demodicosis into a primary form and a secondary form, which is associated mainly with immunosuppression. The clinical manifestations of primary demodicosis may include (i) spinulate demodicosis, currently known as pityriasis folliculorum, involving sebaceous hair follicles without visible inflammation; (ii) papulopustular/nodulocystic or conglobate demodicosis with pronounced inflammation affecting most commonly the perioral and periorbital areas of the face; (iii) ocular demodicosis, inducing chronic blepharitis, chalazia or, less commonly, keratoconjunctivitis; and (iv) auricular demodicosis causing external otitis or myringitis. Secondary demodicosis is usually associated with systemic or local immunosuppression. Treatment is only weakly evidence based, and the most effective concentrations of acaricides remain to be determined. Optimization of an in vitro or ex vivo culture model is necessary for future studies. Endosymbiosis between certain bacteria and Demodex mites in the pathogenesis of demodicosis deserves more attention. Further clinical observations and experiments are needed to prove our hypothesis.
Measuring Hair (2009)

Despite myriad claimed benefits, the primary purpose of a hair conditioner is to reduce the magnitude of the forces associated with combing or brushing of the hair (1), especially when wet (2,3). This is generally accomplished by the deposition of conditioning agents that lubricate the hair fiber, diminishing surface friction and, therefore, combing forces (4).
Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs (2007)

Special delivery: The hydrophobic anticancer drug camptothecin was incorporated into fluorescent mesoporous silica nanoparticles (see image) and delivered to various cancer cells to induce cell death. These results suggest a method to overcome the insolubility problem of many anticancer drugs, which is considered to be one of the major challenges in cancer therapy.
Prediction of T-cell epitopes of hepatitis C virus genotype 5a (2014)

The predicted conserved T-cell epitopes analysed in this study will contribute towards the future design of HCV vaccine candidates which will avoid variation in genotypes, which in turn will be capable of inducing broad HCV specific immune responses.
A chlamydial major outer membrane protein extract as a trachoma vaccine candidate. (1995)

These data demonstrate that despite evidence of vigorous MOMP-specific and other chlamydia-specific serologic and cell-mediated immunity, as well as anamnestic serologic responses to chlamydia, vaccination with OGP-MOMP was only partially protective against chlamydial ocular disease. The partial protection correlated best with tear immunoglobulin A responses after mucosal immunization and with local and systemic immunoglobulin G responses after peripheral immunization, suggesting that alternative chlamydial antigens may have to be considered in future vaccine development to induce more effective protective immunity and that evaluation of efficacy must be appropriate to route of immunization.
Windows NT TCP/IP network administration (1998)

From the Publisher:
Windows NT TCP/IP Network Administration is a complete guide to setting up and running a TCP/IP network on Windows NT. It starts with the fundamentals - the protocols, routing, and setup. Beyond that, all the important networking services provided as part of Windows NT - including IIS, RRAS, DNS, WINS, and DHCP - are presented in detail. This book is the NT administrator's indispensable guide.
Clinical importance of Demodex folliculorum in patients receiving phototherapy (2007)

Demodicidosis should be included in the differential diagnosis of facial eruptions in patients receiving phototherapy.
Chemoradiotherapy in the Management of Locally Advanced Pancreatic Carcinoma: A Qualitative Systematic Review (2009)

No standard treatment exists, but there are two options for treatment of LAPC; these are gemcitabine-based chemotherapy and chemoradiotherapy. Induction chemotherapy followed by a chemoradiotherapy is a promising strategy for selection of patients without early metastatic/progressing disease.
Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells (2010)

Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding of the underlying mechanisms remains incomplete. Here, we show that high expression of the microRNA miR-375 in ERα-positive breast cell lines is a key driver of their proliferation. miR-375 overexpression was caused by loss of epigenetic marks including H3K9me2 and local DNA hypomethylation, dissociation of the transcriptional repressor CTCF from the miR-375 promoter, and interactions of ERα with regulatory regions of miR-375. Inhibiting miR-375 in ERα-positive MCF-7 cells resulted in reduced ERα activation and cell proliferation. A combination of expression profiling from tumor samples and miRNA target prediction identified RASD1 as a potential miR-375 target. Mechanistic investigations revealed that miR-375 regulates RASD1 by targeting the 3' untranslated region in RASD1 mRNA. Additionally, we found that RASD1 negatively regulates ERα expression. Our findings define a forward feedback pathway in control of ERα expression, highlighting new strategies to treat ERα-positive invasive breast tumors.
A Generalisation of the ICP Algorithm for Articulated Bodies (2008)

The ICP algorithm has been extensively used in computer vision for regis-tration and tracking purposes. The original formulation of this method is restricted to the use of non-articulated models. A straightforward generali-sation to articulated structures is achievable through the joint minimisation of all the structure pose parameters, for example using Levenberg-Marquardt (LM) optimisation. However, in this approach the aligning transformation cannot be estimated in closed form, like in the original ICP, and the approach heavily suffers from local minima. To overcome this limitation, some au-thors have extended the straightforward generalisation at the cost of giving up some of the properties of ICP. In this paper, we present a generalisation of ICP to articulated structures, which preserves all the properties of the original algorithm. The key idea is to divide the articulated body into parts, which can be aligned rigidly in the way of the original ICP, with additional constraints to keep the articulated structure intact. Experiments show that our method reduces the residual registration error by a factor of ≈2. 1
Regulation of TRAIL Expression by the Phosphatidylinositol 3-Kinase/Akt/GSK-3 Pathway in Human Colon Cancer Cells (2002)

The intestinal mucosa is a rapidly-renewing tissue characterized by cell proliferation, differentiation, and eventual apoptosis with progression up the vertical gut axis. The inhibition of phosphatidylinositol (PI) 3-kinase by specific chemical inhibitors or overexpression of the lipid phosphatase PTEN enhances enterocyte-like differentiation in human colon cancer cell models of intestinal differentiation. In this report, we examined the role of PI 3-kinase inhibition in the regulation of apoptotic gene expression in human colon cancer cell lines HT29, HCT-116, and Caco-2. Inhibition of PI 3-kinase with the chemical inhibitor wortmannin increased TNF-related apoptosis-inducing ligand (TRAIL; Apo2) mRNA and protein expression. Similarly, overexpression of the tumor suppressor protein PTEN, an antagonist of PI 3-kinase signaling, resulted in the increased expression of TRAIL. Activation of PI 3-kinase by pretreatment with IGF-1, a gut trophic factor, markedly attenuated the induction of TRAIL by wortmannin. Moreover, overexpression of active Akt, a downstream target of PI 3-kinase, or inhibition of GSK-3, a downstream target of active Akt, completely blocked the induction of TRAIL by wortmannin. Consistent with findings that TRAIL is induced by agents that enhance intestinal cell differentiation, TRAIL expression was specifically localized to the differentiated cells of the colon and small bowel. Adenovirus-mediated overexpression of TRAIL increased DNA fragmentation of HCT-116 cells, demonstrating the functional activity of TRAIL induction. Taken together, our findings demonstrate induction of the TRAIL by inhibition of PI 3-kinase in colon cancer cell lines. These results identify TRAIL, a novel TNF family member, as a downstream target of the PI 3-kinase/Akt/GSK-3 pathway and may have important implications for better understanding the role of the PI 3-kinase pathway in intestinal cell homeostasis.
Nanoparticle Assemblies with Molecular Springs: A Nanoscale Thermometer (2005)

A temperature-dependent emission is observed for CdTe nanoparticles connected to Au nanoparticles by a flexible poly(ethyleneglycol) (PEG) link acting as a molecular spring (see picture). The extension of the PEG springs varies depending on the temperature, which causes variations in CdTe emission caused by plasmon–exciton interactions. A theoretical model of plasmon–exciton coupling explains the optical and thermal effects. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z501264_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (2010)

For luminescent quantum dots (QDs) to realize their full potential as intracellular labeling, imaging and sensing reagents, robust noninvasive methods for their delivery to the cellular cytosol must be developed. Our aim in this study was to explore a range of methods aimed at delivering QDs to the cytosol. We have previously shown that QDs functionalized with a polyarginine 'Tat' cell-penetrating peptide (CPP) could be specifically delivered to cells via endocytic uptake with no adverse effects on cellular proliferation. We began by assessing the long-term intracellular fate and stability of these QD-peptide conjugates. We found that the QDs remained sequestered within acidic endolysosomal vesicles for at least three days after initial uptake while the CPP appeared to remain stably associated with the QD throughout this time. We next explored techniques designed to either actively deliver QDs directly to the cytosol or to combine endocytosis with subsequent endosomal escape to the cytosol in several eukaryotic cell lines. Active delivery methods such as electroporation and nucleofection delivered only modest amounts of QDs to the cytosol as aggregates. Delivery of QDs using a variety of transfection polymers also resulted in primarily endosomal sequestration of QDs. However, in one case the commercial PULSin reagent did facilitate a modest cytosolic dispersal of QDs, but only after several days in culture and with significant polymer-induced cytotoxicity. Finally, we demonstrated that an amphiphilic peptide designed to mediate cell penetration and vesicle membrane interactions could mediate rapid QD uptake by endocytosis followed by a slower efficient endosomal release which peaked at 48 h after initial delivery. Importantly, this QD-peptide bioconjugate elicited minimal cytotoxicity in the cell lines tested.
Muscle-Based Gene Therapy and Tissue Engineering to Improve Bone Healing (2002)

Failed fracture healing is a significant problem in orthopaedics, often seen in patients with scaphoid fractures, high-energy injuries, and osteoporosis. Current treatments often result in poor outcomes and donor site morbidity. Gene therapy has been the focus of much recent research to improve bone healing. In the current review, the authors specifically evaluate the use of muscle-derived cells as a gene delivery vehicle and inducible osteoprogenitor cell that can enhance bone regeneration. Muscle-derived cells have been used to deliver bone morphogenetic protein-2 and produce ectopic bone. These cells express osteocalcin and have been found within newly generated bone in locations normally occupied by osteoblasts and osteocytes. Finally, it is shown that muscle-derived cells coupled with ex vivo gene therapy can heal critical-sized calvarial defects.
Dynamic task allocation for robots via auctions (2006)

We present an auction-based method for the allocation of tasks to a group of robots. The robots operate in a 2D environment for which they have a map. Tasks are locations in the map that have to be visited by the robots. Unexpected obstacles and other delays may prevent a robot from being able to complete its allocated tasks. Therefore tasks not yet achieved are rebid every time a robot accomplishes a task. This provides an opportunity to improve the allocation of the remaining tasks and to reduce the overall task completion time. We present experimental results that we have obtained in simulation using Player/Stage with this task allocation mechanism
Animal models of dementia (1995)

Abstract The major use of animal models for dementia is in the development of new therapeutic drugs. In contrast to other areas in psychopharmacology, where the predictive validity of animal models can be established by examining their response to known therapeutic agents, the search for antidementia drugs is hampered by the absence of recognized clinically effective reference compounds. Research scientists are therefore obliged to validate their models in terms of their similarity to the clinical condition. A second problem is the therapeutic target. Although antidementia drugs are intended to improve cognition in a general sense, the foremost therapeutic targets are the deficits in memory and attention associated with aging. The aging animal would appear to represent the best available model providing it can be shown that the cognitive deficits observed are similar to those observed in old age in humans. A logical consequence of this approach is to validate other experimental models in terms of their resemblance to naturally occurring age‐related impairments. To illustrate these points, this paper reviews data obtained in aging animals in various behavioral models and the effects of drugs thereon. Comparisons are made between drug effects in aged animals with those observed in experimental models in young animals in which cognitive deficits are induced by anticholinergic drug treatment or lesions to cholinergic‐rich brain regions. It is concluded that aging induces cognitive deficits mainly associated with short‐term memory but that other aspects of cognition, namely attention and information processing speed, also decline with age. Putative antidementia drugs, particularly those facilitating cholinergic transmission, appear frequently to have more marked effects in experimental deficit models than in aged animals themselves. © 1995 Wiley‐Liss, Inc.
Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death (2012)

Cancer cells are long known to exhibit increased aerobic glycolysis, but glycolytic inhibition has not offered a viable chemotherapeutic strategy in part because of the systemic toxicity of antiglycolytic agents. However, recent studies suggest that a combined inhibition of glycolysis and mitochondrial function may help overcome this issue. In this study, we investigated the chemotherapeutic efficacies of mitochondria-targeted drugs (MTD) in combination with 2-deoxy-d-glucose (2-DG), a compound that inhibits glycolysis. Using the MTDs, termed Mito-CP and Mito-Q, we evaluated relative cytotoxic effects and mitochondrial bioenergetic changes in vitro. Interestingly, both Mito-CP and Mito-Q synergized with 2-DG to decrease ATP levels in two cell lines. However, with time, the cellular bioenergetic function and clonogenic survival were largely restored in some cells. In a xenograft model of human breast cancer, combined treatment of Mito-CP and 2-DG led to significant tumor regression in the absence of significant morphologic changes in kidney, liver, or heart. Collectively, our findings suggest that dual targeting of mitochondrial bioenergetic metabolism with MTDs and glycolytic inhibitors such as 2-DG may offer a promising chemotherapeutic strategy.