gebhart/patrepeval huggingface dataset:
Limited Downlink Network Coordination in Cellular Networks (2007)

We investigate the downlink throughput of cellular systems where groups of M antennas - either co-located or spatially distributed - transmit to a subset of a total population of K > M users in a coherent, coordinated fashion in order to mitigate intercell interference. We consider two types of coordination: the capacity-achieving technique based on dirty paper coding (DPC), and a simpler technique based on zero-forcing (ZF) beamforming with per-antenna power constraints. During a given frame, a scheduler chooses the subset of the K users in order to maximize the weighted sum rate, where the weights are based on the proportional-fair scheduling algorithm. We consider the weighted average sum throughput among K users per cell in a multi-cell network where coordination is limited to a neighborhood of M antennas. Consequently, the performance of both systems is limited by interference from antennas that are outside of the M coordinated antennas. Compared to a 12-sector baseline which uses the same number of antennas per cell site, the throughput of ZF and DPC achieve respective gains of 1.5 and 1.75.
Species differences in small molecule binding to αIIbβ3 are the result of sequence differences in 2 loops of the αIIb β propeller (2008)

Compared with human platelets, rodent platelets are less responsive to peptides and peptidomimetics containing an arginine-glycine-aspartic acid (RGD) motif. Using chimeric human-rat alphaIIbbeta3 molecules, we found that this difference in Arg-Gly-Asp-Ser (RGDS) sensitivity was the result of amino acid substitutions at residues 157, 159, and 162 in the W3:4-1 loop and an Asp-His replacement at residue 232 in the W4:4-1 loop of the alphaIIb beta propeller. Introducing the entire rat W3:4-1 and W4:4-1 loops into human alphaIIbbeta3 also decreased the inhibitory effect of the disintegrins, echistatin and eristostatin, and the alphaIIbbeta3 antagonists, tirofiban and eptifibatide, on fibrinogen binding, whereas the specific point mutations did not. This suggests that RGDS interacts with alphaIIb in a different manner than with these small molecules. None of these species-based substitutions affected the ability of alphaIIbbeta3 to interact with RGD-containing macromolecules. Thus, human von Willebrand factor contains an RGD motif and binds equally well to adenosine diphosphate-stimulated human and rodent platelets, implying that other motifs are responsible for maintaining ligand binding affinity. Many venoms contain RGD-based toxins. Our data suggest that these species amino acids differences in the alphaIIb beta-propeller represent an evolutionary response by rodents to maintain hemostasis while concurrently protecting against RGD-containing toxins.
Probabilistic CFG with latent annotations (2005)

This paper defines a generative probabilistic model of parse trees, which we call PCFG-LA. This model is an extension of PCFG in which non-terminal symbols are augmented with latent variables. Fine-grained CFG rules are automatically induced from a parsed corpus by training a PCFG-LA model using an EM-algorithm. Because exact parsing with a PCFG-LA is NP-hard, several approximations are described and empirically compared. In experiments using the Penn WSJ corpus, our automatically trained model gave a performance of 86.6% (F1, sentences ≤ 40 words), which is comparable to that of an unlexicalized PCFG parser created using extensive manual feature selection.
Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis (1991)

The expression pattern and DNA sequence of a newly identified gene, CNC (cap'n'collar), suggest a role for this gene in cephalic patterning during Drosophila embryogenesis. In situ hybridization reveals transcripts localized to the mandibular segment and the hypopharyngeal and labral primordia first detectable in late blastoderm stages. Sequence analysis of cDNA clones from the CNC locus shows the CNC gene product to be related to transcription factors of the leucine zipper (bZIP) class. Based on its protein sequence, we propose that CNC is a subunit of a heterodimeric regulatory protein involved in the control of head morphogenesis.
Nucleotide and deduced amino acid sequences for the four variable domains of the major outer membrane proteins of the 15 Chlamydia trachomatis serovars (1989)

The amino acid sequences of major outer membrane proteins (MOMPs) from Chlamydia trachomatis serovars A, B, C, L1, and L2 are predominantly conserved but have four variable domains (VDs) in which major neutralizing and serotyping antigenic determinants are located. Because these MOMP VDs are primarily responsible for antigenic differences between serovars and are associated with important immunological and biological properties, we undertook studies focused on defining these sequences within the MOMPs of all 15 C. trachomatis serovars. We used oligonucleotide primer extension sequencing of MOMP mRNA to determine the nucleotide and deduced amino acid sequences of the four MOMP VDs of the 15 C. trachomatis serovars. Comparative amino acid sequence homologies of all four domains separated the serovars into three groups: group 1, serovars B, Ba, D, E, L1, and L2; group 2, serovars G and F; and group 3, serovars A, C, H, I, J, K, and L3. Hydrophilicity and charge values for each domain were determined. The MOMP VDs of given serovars with the greatest total hydrophilicity and charge values were found to be the location of antigenic determinants recognized by MOMP-specific monoclonal antibodies. These findings should be useful for predicting MOMP antigenic determinants and testing the antigenic properties of these VDs by using synthetic peptides corresponding to each MOMP VD. The potential usefulness of the VD sequence information is discussed in relation to the development of defined synthetic peptides and oligonucleotides that may be used to develop new serological and diagnostic assays for C. trachomatis infections.
Learning Word Vectors for Sentiment Analysis (2011)

Unsupervised vector-based approaches to semantics can model rich lexical meanings, but they largely fail to capture sentiment information that is central to many word meanings and important for a wide range of NLP tasks. We present a model that uses a mix of unsupervised and supervised techniques to learn word vectors capturing semantic term–document information as well as rich sentiment content. The proposed model can leverage both continuous and multi-dimensional sentiment information as well as non-sentiment annotations. We instantiate the model to utilize the document-level sentiment polarity annotations present in many online documents (e.g. star ratings). We evaluate the model using small, widely used sentiment and subjectivity corpora and find it out-performs several previously introduced methods for sentiment classification. We also introduce a large dataset of movie reviews to serve as a more robust benchmark for work in this area. recognition, part of speech tagging, and document retrieval (Turney and Pantel, 2010; Collobert and Weston, 2008; Turian et al., 2010). In this paper, we present a model to capture both semantic and sentiment similarities among words. The semantic component of our model learns word vectors via an unsupervised probabilistic model of documents. However, in keeping with linguistic and cognitive research arguing that expressive content and descriptive semantic content are distinct (Kaplan, 1999; Jay, 2000; Potts, 2007), we find that this basic model misses crucial sentiment information. For example, while it learns that wonderful and amazing are semantically close, it doesn’t capture the fact that these are both very strong positive sentiment words, at the opposite end of the spectrum from terrible and awful. Thus, we extend the model with a supervised sentiment component that is capable of embracing many social and attitudinal aspects of meaning (Wilson
Pancreatoduodenectomy: a complicated solution. (1990)

1. Pancreatoduodenectomy is an effective operative procedure for benign large tumors and cancers of the pancreas and periampullary sites and extensive trauma to these areas. 2. Pancreatoduodenectomy may be performed in two stages: total excision of pancreas, subtotal excision, and pyloric exclusion procedures. 3. Carcinoma of the proximal pancreas is a serious medicosurgical problem, and radical pancreatoduodenectomy is the most effective form of therapy. 4. Pancreatoduodenectomy is a major operative procedure with serious intraoperative and postoperative complications that are directly related to the experience of the surgeon.
Biodegradable nanofiber-based piezoelectric transducer (2019)

Piezoelectric materials, a type of "smart" material that generates electricity while deforming and vice versa, have been used extensively for many important implantable medical devices such as sensors, transducers, and actuators. However, commonly utilized piezoelectric materials are either toxic or nondegradable. Thus, implanted devices employing these materials raise a significant concern in terms of safety issues and often require an invasive removal surgery, which can damage directly interfaced tissues/organs. Here, we present a strategy for materials processing, device assembly, and electronic integration to 1) create biodegradable and biocompatible piezoelectric PLLA [poly(l-lactic acid)] nanofibers with a highly controllable, efficient, and stable piezoelectric performance, and 2) demonstrate device applications of this nanomaterial, including a highly sensitive biodegradable pressure sensor for monitoring vital physiological pressures and a biodegradable ultrasonic transducer for blood-brain barrier opening that can be used to facilitate the delivery of drugs into the brain. These significant applications, which have not been achieved so far by conventional piezoelectric materials and bulk piezoelectric PLLA, demonstrate the PLLA nanofibers as a powerful material platform that offers a profound impact on various medical fields including drug delivery, tissue engineering, and implanted medical devices.
Natural History of Asymptomatic Left Ventricular Systolic Dysfunction in the Community (2003)

Individuals with ALVD in the community are at high risk of CHF and death, even when only mild impairment of EF is present. Additional studies are needed to define optimal therapy for mild ALVD.
The dragon continuous speech recognition system (1990)

We present a 1000-word continuous speech recognition (CSR) system that operates in real time on a personal computer (PC). The system, designed for large vocabulary natural language tasks, makes use of phonetic Hidden Markov models (HMM) and incorporates acoustic, phonetic, and linguistic sources of knowledge to achieve high recognition performance. We describe the various components of this system. We also present our strategy for achieving real time recognition on the PC. Using a 486-based PC with a 29K-based add-on board, the recognizer has been timed at 1.1 times real time.
Guiding people to information (2000)

We describe Rosetta, a digital library system for scientific literature. Rosetta makes it easy for people to find the information for which they are looking even when using short, imprecise queries. Rosetta indexes research articles based on the way they have been described when cited in other documents. The concise descriptions that occur in citations are similar to the short queries people typically form when searching; therefore, citations make a better basis for indexing than do the words used within a research article itself. Using this indexing technique we are able to provide a user interface that presents users with an automatically generated directory of the information space surrounding a query. Our objective with this interface is to present people with the information for which they have asked as well as the information for which they may have intended to ask.
Preparation of Platinum Supported on Pregraphitized Carbon Blacks (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Platinum Supported on Pregraphitized Carbon BlacksF. Coloma, A. Sepulveda-Escribano, J. L. G. Fierro, and F. Rodriguez-ReinosoCite this: Langmuir 1994, 10, 3, 750–755Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://doi.org/10.1021/la00015a025Request reuse permissionsArticle Views1031Altmetric-Citations166LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (773 KB) Get e-Alertsclose Get e-Alerts
Multi-Class Uncertainty Calibration via Mutual Information Maximization-based Binning (2020)

Post-hoc multi-class calibration is a common approach for providing high-quality confidence estimates of deep neural network predictions. Recent work has shown that widely used scaling methods underestimate their calibration error, while alternative Histogram Binning (HB) methods often fail to preserve classification accuracy. When classes have small prior probabilities, HB also faces the issue of severe sample-inefficiency after the conversion into K one-vs-rest class-wise calibration problems. The goal of this paper is to resolve the identified issues of HB in order to provide calibrated confidence estimates using only a small holdout calibration dataset for bin optimization while preserving multi-class ranking accuracy. From an information-theoretic perspective, we derive the I-Max concept for binning, which maximizes the mutual information between labels and quantized logits. This concept mitigates potential loss in ranking performance due to lossy quantization, and by disentangling the optimization of bin edges and representatives allows simultaneous improvement of ranking and calibration performance. To improve the sample efficiency and estimates from a small calibration set, we propose a shared class-wise (sCW) calibration strategy, sharing one calibrator among similar classes (e.g., with similar class priors) so that the training sets of their class-wise calibration problems can be merged to train the single calibrator. The combination of sCW and I-Max binning outperforms the state of the art calibration methods on various evaluation metrics across different benchmark datasets and models, using a small calibration set (e.g., 1k samples for ImageNet).
Apolipoprotein E ε4 is associated with rapid progression of multiple sclerosis (2001)

These results suggest no effect of the APOE genotype on susceptibility to MS, but indicate an association of the APOE epsilon4 allele with a more severe course of the disease.
Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury. (2002)

Amyloid beta protein (Abeta) increases free radical production and lipid peroxidation in PC12 nerve cells, leading to apoptosis and cell death. The effect of ursolic acid from Origanum majorana L. on Abeta-induced neurotoxicity was investigated using PC12 cells. Pretreatment with isolated ursolic acid and vitamin E prevented the PC12 cell from reactive oxygen species (ROS) toxicity that is mediated by Abeta. The ursolic acid resulted in decreased Abeta toxicity assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH), and trypan blue assay. Thus, treatment with these antioxidants inhibited the Abeta-induced neurotoxic effect. Therefore, these results indicate that micromolar Abeta-induced oxidative cell death is reduced by ursolic acid from Origanum majorana L.
Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. (1992)

We estimated whether single collections of cord blood contained sufficient cells for hematopoietic engraftment of adults by evaluating numbers of cord blood and adult bone marrow myeloid progenitor cells (MPCs) as detected in vitro with steel factor (SLF) and hematopoietic colony-stimulating factors (CSFs). SLF plus granulocyte-macrophage (GM)-CSF detected 8- to 11-fold more cord blood GM progenitors [colony-forming units (CFU)-GM] than cells stimulated with GM-CSF or 5637 conditioned medium (CM), growth factors previously used to estimate cord blood CFU-GM numbers. SLF plus erythropoietin (Epo) plus interleukin 3 (IL-3) enhanced detection of cord blood multipotential (CFU-GEMM) progenitors 15-fold compared to stimulation with Epo plus IL-3. Under the same conditions, bone marrow CFU-GM and CFU-GEMM were only enhanced in detection 2- to 4- and 6- to 8-fold. Increased detection of cord blood CFU-GEMM correlated directly with decreased detection of cord blood erythroid burst-forming units (BFU-E). In contrast, adult bone marrow CFU-GEMM and BFU-E numbers were both enhanced by SLF plus Epo plus IL-3. This suggests that most cord blood BFU-E may actually be CFU-GEMM. Cord blood collections (n = 17) contained numbers of MPCs (especially CFU-GM) similar to the number found in nine autologous bone marrow collections. To assess additional sources of MPCs, the peripheral blood of 1-day-old infants was assessed. However, average concentrations of MPCs circulating in these infants were only 30-46% that in their cord blood. Expansion of cord blood MPCs was also evaluated. Incubation of cord blood cells for 7 days with SLF resulted in 7.9-, 2.2-, and 2.7-fold increases in numbers of CFU-GM, BFU-E, and CFU-GEMM compared to starting numbers; addition of a CSF with SLF resulted in even greater expansion of MPCs. The results suggest that cord blood contains a larger number of early profile MPCs than previously recognized and that there are probably sufficient numbers of cells in a single cord blood collection to engraft an adult. Although the expansion data must be considered with caution, as human marrow repopulating cells cannot be assessed directly, in vitro expansion of cord blood stem and progenitor cells may be feasible for clinical transplantation.
PF-03732010: A Fully Human Monoclonal Antibody against P-Cadherin with Antitumor and Antimetastatic Activity (2010)

These findings suggest that interrupting the P-cadherin signaling pathway may be a novel therapeutic approach for cancer therapy. PF-03732010 is presently undergoing evaluation in Phase 1 clinical trials.
Thymus-Independent Antigens: The Preparation of Covalent, Hapten-Ficoll Conjugates (1975)

A general approach is presented for covalently attaching carboxyl and primary amino groups to Ficoll and other high molecular weight polysaccharides in a readily controlled manner. The polysaccharides are omicron-carboxymethylated with chloroacetate in NaOH solutions. Amino groups are next introduced by monoamide formation with ethylenediamine using a water-soluble carbodiimide. Reactions are carried out in aqueous solutions; excess reactants and by-products are removed by dialysis. Three different ways for coupling the 2,4-dinitrophenyl hapten to the amino derivative of Ficoll are described. Preliminary evidence indicates that 2,4-dinitrophenyl-Ficolls, prepared by procedures developed in this study, are potent thymus-independent antigens which can specifically stimulate B cells both in vivo and in vitro. Hapten-Ficoll conjugates should be exceptionally useful for studies of B lymphocyte activation because of the ready availability of the starting material and the ease with which a wide variety of hapten derivatives may be prepared.
Near-infrared optical properties ofex vivohuman skin and subcutaneous tissues measured using the Monte Carlo inversion technique (1998)

The absorption and transport scattering coefficients of caucasian and negroid dermis, subdermal fat and muscle have been measured for all wavelengths between 620 and 1000 nm. Samples of tissue 2 mm thick were measured ex vivo to determine their reflectance and transmittance. A Monte Carlo model of the measurement system and light transport in tissue was then used to recover the optical coefficients. The sample reflectance and transmittance were measured using a single integrating sphere 'comparison' method. This has the advantage over conventional double-sphere techniques in that no corrections are required for sphere properties, and so measurements sufficiently accurate to recover the absorption coefficient reliably could be made. The optical properties of caucasian dermis were found to be approximately twice those of the underlying fat layer. At 633 nm, the mean optical properties over 12 samples were 0.033 mm(-1) and 0.013 mm(-1) for absorption coefficient and 2.73 mm(-1) and 1.26 mm(-1) for transport scattering coefficient for caucasian dermis and the underlying fat layer respectively. The transport scattering coefficient for all biological samples showed a monotonic decrease with increasing wavelength. The method was calibrated using solid tissue phantoms and by comparison with a temporally resolved technique.
Cloning and Sequence Analysis of Simian Transforming Growth Factor-β cDNA (1987)

We have isolated a cDNA clone coding for the simian TGF-beta precursor from a cDNA library made from an African green monkey cell line, BSC-40. The deduced amino acid sequence of the mature simian TGF-beta shows 100% homology with that of the human TGF-beta: Strong sequence homology was found between the precursor regions of the human and simian proteins with only five amino acid changes out of 278. The simian (and murine) precursor sequence was found to code for one less amino acid residue than the human. The implications of these results with respect to the isolation of a growth inhibitor from these cells functionally related to the TGF-beta molecule are discussed.
In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone (2015)

MOD-4023 is a novel long-acting version of human growth hormone (hGH), containing the carboxy-terminal peptide (CTP) of human chorionic gonadotropin (hCG). MOD-4023 is being developed as a treatment for adults and children with growth hormone deficiency (GHD), which would require fewer injections than currently available GH formulations and thus reduce patient discomfort and increase compliance. This study characterizes MOD-4023's binding affinities for the growth hormone receptor, as well as the pharmacokinetic and pharmacodynamics, toxicology, and safety profiles of repeated dosing of MOD-4023 in Sprague-Dawley rats and Rhesus monkeys. Although MOD-4023 exhibited reduced in vitro potency and lower affinity to the GH receptor than recombinant hGH (rhGH), administration of MOD-4023 every 5 days in rats and monkeys resulted in exposure comparable to daily rhGH, and the serum half-life of MOD-4023 was significantly longer. Repeated administration of MOD-4023 led to elevated levels of insulin-like growth factor 1 (IGF-1), and twice-weekly injections of MOD-4023 resulted in larger increase in weight gain with fewer injections and a lower accumulative hGH dose. Thus, the increased half-life of MOD-4023 in comparison to hGH may increase the frequency of protein-receptor interactions and compensate for its decreased in vitro potency. MOD-4023 was found to be well-tolerated in rats and monkeys, with minimal adverse events, suggesting an acceptable safety profile. These results provide a basis for the continued clinical development of MOD-4023 as a novel treatment of GHD in children and adults.