gebhart/patrepeval huggingface dataset:
Environmentally Benign Solution for Recycling Electronic Waste Using the Principles of Green Chemistry (2014)

In electronic waste recycling industry, printed wire boards (PWBs)/integrated chips (ICs) recycling is one of the most challenge tasks due to the fact that PWBs/ICs are diverse and complex in terms of materials and components makeup,as well as the original equipment manufacturing processes. In this paper, we will present environmental benign solution to recover valuable metals from PWB and integrated circuit chips (ICs) dissembled from waste PWB, based on green chemistry methodologies. We will demonstrate that the process/chemistry can selectively separate and recover precious metals from base metals. The 95%-99% recovery rate of precious metals can be achieved from the recycling of PWB and integrated circuit chips.
Regression of Lung and Colon Cancer Xenografts by Depleting or Inhibiting RLIP76 (Ral-Binding Protein 1) (2007)

Ral-binding protein 1 (RALBP1) is a stress-responsive and stress-protective multispecific transporter of glutathione conjugates (GS-E) and xenobiotic toxins. It is frequently overexpressed in malignant cells and plays a prominent antiapoptotic role selectively in cancer cells through its ability to control cellular concentration of proapoptotic oxidized lipid byproducts. In the absence of chemotherapy, depletion or inhibition of RALBP1 causes regression of syngeneic mouse B16 melanoma. Because RALBP1 transports anthracycline and Vinca alkaloid drugs, as well as GS-E, and because it confers resistance to these drugs, we proposed that depletion or inhibition of RALBP1 should cause regression of human solid tumors that overexpress RALBP1 and augment chemotherapy efficacy. Non-small-cell lung cancer (NSCLC) H358 and H520 and colon SW480 cell lines were used. Cytotoxic synergy between anti-RALBP1 immunoglobulin G (IgG), cis-diammine-dichloroplatinum (II) [CDDP], and vinorelbine was examined in cell culture and xenografts of NSCLC cells. Effects of RALBP1 depletion by antisense were examined in xenografts of NSCLC H358, NSCLC H520, and colon SW480 cells. RALBP1 depletion by phosphorothioate antisense was confirmed and was associated with rapid, complete, and sustained remissions in established s.c. human lung and colon xenografts. RALBP1 inhibition by anti-RALBP1 IgG was equally as effective as antisense and enhanced CDDP-vinorelbine in lung cancer xenografts. These studies show that RALBP1 is a transporter that serves as a key effector function in cancer cell survival and is a valid target for cancer therapy, and confirm that inhibitory modulation of RALBP1 transport activity at the cell surface is sufficient for antitumor effects.
Low-Light Irradiation at the Beginning or the End of the Daily Dark Period Accelerates Leaf Expansion and Growth in Spinacia oleracea L. (2010)

Supplemental red light irradiation at the beginning of the dark period or blue light irradiation at the end of the dark period at a low level (0.6% of the irradiance of the light period) compared to no supplemental irradiation (control) promoted biomass production and was accompanied by an increase in the leaf area in spinach. Photosynthetic rate and stomatal conductance measured under white light in the leaves of plants grown under supplemental lighting during the dark period were the same as those of the control plants. Microscopic analysis of the transverse and longitudinal directions of the leaves revealed that red light irradiation at the beginning of the dark period increased leaf cell size, while leaf cell size was not affected by blue light irradiation at the end of the dark period. These results suggest that red light irradiation at the beginning of the dark period accelerates leaf expansion by an increase in leaf cell size and blue light irradiation at the end of the dark period accelerates leaf expansion by an increase in leaf cell number. The increase in leaf area by supplemental lighting leads to an increase in photosynthesis at the whole-plant level, which contributes to the enhancement of biomass production under suboptimal light irradiation.
Tailoring Elastic Properties of Silica Aerogels Cross-Linked with Polystyrene (2009)

The effect of incorporating an organic linking group, 1,6-bis(trimethoxysilyl)hexane (BTMSH), into the underlying silica structure of a styrene cross-linked silica aerogel is examined. Vinyltrimethoxysilane (VTMS) is used to provide a reactive site on the silica backbone for styrene polymerization. Replacement of up to 88 mol % of the silicon from tetramethoxyorthosilicate with silicon derived from BTMSH and VTMS during the making of silica gels improves the elastic behavior in some formulations of the cross-linked aerogels, as evidenced by measurement of the recovered length after compression of samples to 25% strain. This is especially true for some higher density formulations, which recover nearly 100% of their length after compression to 25% strain twice. The compressive modulus of the more elastic monoliths ranged from 0.2 to 3 MPa. Although some of these monoliths had greatly reduced surface areas, changing the solvent used to produce the gels from methanol to ethanol increased the surface area in one instance from 6 to 220 m(2)/g with little affect on the modulus, elastic recovery, porosity, or density.
The Prevalence and Risk Factors of Functional Dyspepsia in a Multiethnic Population in the United States (2004)

Most subjects with dyspepsia have FD. The prevalence of FD is high but predictors of FD remain poorly defined.
Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes (2006)

Adaptor proteins (AP) play important roles in the sorting of proteins from the trans-Golgi network, but how they function in the sorting of various melanosome-specific proteins such as Pmel17, an essential structural component of melanosomes, in melanocytes is unknown. We characterized the processing and trafficking of Pmel17 via adaptor protein complexes within melanocytic cells. Proteomics analysis detected Pmel17, AP1 and AP2, but not AP3 or AP4 in early melanosomes. Real-time PCR, immunolabeling and tissue in-situ hybridization confirmed the coexpression of AP1 isoforms mu1A and mu1B (expressed only in polarized cells) in melanocytes and keratinocytes, but expression of mu1B is missing in some melanoma cell lines. Transfection with AP1 isoforms (mu1A or mu1B) showed two distinct distribution patterns that involved Pmel17, and only mu1B was able to restore the sorting of Pmel17 to the plasma membrane in cells lacking mu1B expression. Finally, we established that expression of mu1B is regulated physiologically in melanocytes by UV radiation or DKK1. These results show that Pmel17 is sorted to melanosomes by various intracellular routes, directly or indirectly through the plasma membrane, and the presence of basolateral elements in melanocytes suggests their polarized nature.
Sentinel Lymph Node Imaging Using Quantum Dots in Mouse Tumor Models (2007)

We demonstrate that quantum dots injected into two model tumors rapidly migrate to sentinel lymph nodes. PEG-coated quantum dots having terminal carboxyl, amino, or methoxyl groups all migrated from the tumor to surrounding lymph nodes similarly. Passage from the tumor through lymphatics to adjacent nodes could be visualized dynamically through the skin; at least two nodes could usually be defined. Imaging during necropsy confirmed confinement of the quantum dots to the lymphatic system and demonstrated easy tagging of sentinel lymph nodes for pathology. Examination of the sentinel nodes identified by quantum dot localization showed that at least some contained metastatic tumor foci.
Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases (2014)

The correct establishment and maintenance of DNA methylation patterns are critical for mammalian development and the control of normal cell growth and differentiation. DNA methylation has profound effects on the mammalian genome, including transcriptional repression, modulation of chromatin structure, X chromosome inactivation, genomic imprinting, and the suppression of the detrimental effects of repetitive and parasitic DNA sequences on genome integrity. Consistent with its essential role in normal cells and predominance at repetitive genomic regions, aberrant changes of DNA methylation patterns are a common feature of diseases with chromosomal and genomic instabilities. In this context, the functions of DNA methyltransferases (DNMTs) can be affected by mutations or alterations of their expression. DNMT3B, which is involved in de novo methylation, is of particular interest not only because of its important role in development, but also because of its dysfunction in human diseases. Expression of catalytically inactive isoforms has been associated with cancer risk and germ line hypomorphic mutations with the ICF syndrome (Immunodeficiency Centromeric instability Facial anomalies). In these diseases, global genomic hypomethylation affects repeated sequences around centromeric regions, which make up large blocks of heterochromatin, and is associated with chromosome instability, impaired chromosome segregation and perturbed nuclear architecture. The review will focus on recent data about the function of DNMT3B, and the consequences of its deregulated activity on pathological DNA hypomethylation, including the illicit activation of germ line-specific genes and accumulation of transcripts originating from repeated satellite sequences, which may represent novel physiopathological biomarkers for human diseases. Notably, we focus on cancer and the ICF syndrome, pathological contexts in which hypomethylation has been extensively characterized. We also discuss the potential contribution of these deregulated protein-coding and non-coding transcription programs to the perturbation of cellular phenotypes.
Rapid detection of bovine viral diarrhea virus by using RNA extracted directly from assorted specimens and a one-tube reverse transcription PCR assay (1995)

We describe a simple method for the rapid detection of bovine viral diarrhea virus (BVDV) that uses a one-tube reverse transcription PCR (RT-PCR) and total RNA extracted directly from a variety of bovine specimens, including whole blood and tissues. Reagents for both RT and PCR were combined in a one-tube, single-buffer system, and amplification was performed with a single uninterrupted thermal cycling program. Using the novel cationic surfactant tetradecyltrimethylammonium oxalate (Catrimox-14), we consistently extracted RT-PCR-quality RNA from specimens containing blood. Amplification with primers derived from conserved sequences within the BVDV 5'-untranslated region yielded a 244-bp product. Assay specificity was confirmed by ethidium bromide-stained gel electrophoresis and by chemiluminescence-assayed Southern blot hybridizations involving BVDV 5'-untranslated region-specific digoxigenin-labelled cDNA probes. The assay detection level was 0.1 50% tissue culture infectious dose of BVDV when ethidium bromide-stained gel electrophoresis was used and 0.01 50% tissue culture infectious dose of BVDV when Southern blot hybridization was used. Our method is an alternative to the conventional cell culture assays used in a diagnostic laboratory and is an improvement over existing RT-PCR assays for BVDV.
Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer (1994)

'It will form an important addition to a scientific library and a useful addition to the (contributions series) which should be part of any obstetrics and gynaecology library.' New Zealand Journal of Obstetrics and Gynaecology
Significance of TWIST and E‐cadherin expression in the metastatic progression of prostatic cancer (2007)

These results suggest that TWIST may serve as a prognostic marker for high-grade prostatic cancer. In addition, up-regulation of TWIST in combination with aberrant E-cadherin expression in primary prostatic cancer specimens may predict development of distal metastatic disease.
Importance of Terminal Base Pair Hydrogen-Bonding in 3‘-End Proofreading by the Klenow Fragment of DNA Polymerase I (2000)

We describe studies aimed at evaluating the physical factors governing the rate of 3'-end proofreading by the Klenow fragment of E. coli DNA polymerase I. Two nonpolar deoxynucleoside isosteres containing 2,4-difluorotoluene (F) and 4-methylbenzimidazole (Z), which are non-hydrogen-bonding shape mimics of thymine and adenine, respectively, are used to investigate the effects of base pair geometry and stability on the rate of this exonuclease activity. Steady-state kinetics measurements show that complementary T.A base pairs at the end of a primer-template duplex are edited 14-40-fold more slowly than mismatches. By contrast, a 3'-end T residue in a T. Z pair is edited at a rate equivalent to that of natural base mismatches despite the fact that it resembles a T.A pair in structure. Similarly, the A in an A.F pair is edited as rapidly as a mismatched pair despite its close structural mimicry of an A.T pair. Interestingly, when the base pairs are reversed and F or Z is located at the 3'-end, they are edited more slowly, possibly implicating specific interactions between the exonuclease domain and the base of the nucleotide being edited. Finally, thermal denaturation studies are carried out to investigate the relationship between editing and the ease of unwinding of the duplex. The rapid editing of bases opposite F or Z residues at the duplex terminus seems to correlate well with the stability of these base pairs when placed in a context resembling a primer-template duplex. In general, the rate of 3'-end editing appears to be governed by the rate of fraying of the DNA terminal pair, and base pair geometry appears to have little effect.
Review Article: Plasma–surface interactions at the atomic scale for patterning metals (2017)

Building upon the depth and breadth of Harold Winters's work, this paper pays tribute to his pioneering contribution in the field of plasma etching of metals, and how that knowledge base helps guide the fundamental research in these areas. The fundamental understanding of the plasma–surface interactions during metal etch is key to achieve desirable etch efficacy and selectivity at the atomic scale. This paper presents a generalized methodology, combining thermodynamic assessment and kinetic verification of surface reactions, using copper, magnetic metals, and noble metals as examples, in an effort to demonstrate the applicability of this strategy in tailoring plasma–surface interactions at the atomic scale for a wide range of materials.
Visualizing Social Networks. (2000)

The use of visual images is common in many branches of science. And reviewers often suggest that such images are important for progress in the various fields (Koestler, 1964; Arnheim, 1970; Taylor, 1971; Tukey, 1972; Klovdahl, 1981; Tufte, 1983; Belien and Leenders). The historian Alfred Crosby (1997) has gone much further. He has proposed that visualization is one of only two factors that are responsible for the explosive development of all of modern science. The other is measurement.
Electrolytes for Lithium‐Ion Batteries with High‐Voltage Cathodes (2013)

The development of a thorough understanding of the reactions of an electrolyte of a lithium-ion battery with the surface of high-voltage cathode materials and the development of novel electrolytes capable of long-term reversible cycling to high voltage is of great current interest. The high oxidation potential of the cathode surface leads to oxidation reactions of the electrolyte components near the interface. An investigation of the thermal stability of the surface layers formed on cathode materials through the combined use of SEM, thermal gravimetric analysis (TGA), and XPS revealed that the cathode particles were found to enhance the thermal stability of the electrolyte at moderately elevated temperatures. Cycling Li-ion cells to high voltage typically results in low coulombic efficiency and poor cycle life. The primary contributor to poor cycling efficiency is the electrochemical oxidation reaction of the electrolytes at high positive potentials.
HIF-1&#945; and Calcium Signaling as Targets for Treatment of Prostate Cancer by Cardiac Glycosides (2009)

Prostate cancer possesses its unique feature of low proliferation rate and slow growth. Ca(2+)-induced apoptosis is not dependent on cell cycle progression and targeting this pathway could circumvent the problems encountered using current cytotoxic chemotherapies for prostate cancer. Hypoxia-inducible factor 1alpha (HIF-1alpha) is another novel cancer drug target and inhibitors of hypoxia-response pathway are being developed. Digoxin and other cardiac glycosides, known inhibitors of the alpha-subunit of sarcolemmal Na(+)K(+)-ATPase, were recently found to block tumor growth via the inhibition of HIF-1alpha synthesis. Thus, cardiac glycosides disrupt two important cellular pathways and, therefore, may be useful as an anticancer therapy. This review will focus on HIF-1alpha and calcium signaling as novel cancer drug targets in prostate cancer. The possible application of digoxin and other cardiac glycosides in cancer therapeutics especially in prostate cancer is discussed.
Peptide antagonism as a mechanism for NK cell activation (2010)

Inhibition of natural killer (NK) cells is mediated by MHC class I receptors including the killer cell Ig-like receptor (KIR). We demonstrate that HLA-C binding peptides can function as altered peptide ligands for KIR and antagonize the inhibition mediated by KIR2DL2/KIR2DL3. Antagonistic peptides promote clustering of KIR at the interface of effector and target cells, but do not result in inhibition of NK cells. Our data show that, as for T cells, small changes in the peptide content of MHC class I can regulate NK cell activity.
An Application of Relaxation Labeling to Line and Curve Enhancement (1977)

A relaxation process is described and is applied to the detection of smooth lines and curves in noisy, real world images. There are nine labels associated with each image point, eight labels indicating line segments at various orientations and one indicating the no-line case. Attached to each label is a probability. In the relaxation process, interaction takes place among the probabilities at neighboring points. This permits line segments in compatible orientations to strengthen one another, and incompatible segments to weaken one another. Similarly, no-line labels are reinforced by neighboring no-line labels and weakened by appropriately oriented line labels. This process converges, in only a few iterations, to a condition in which points lying on long curves have achieved high line probabilities, while other points have high no-line probabilities, There is some tendency, under this process, for curves to thicken; however, a thinning procedure can be incorporated to counteract this. The process is effective even for curves of low contrast, and even when many curves lie close to one another.
Corrosion Inhibitors for Hot-Carbonate Systems (1961)

The evaluation of the effectiveness of various inhibitors on the corrosion of steel in boiling solutions of potassium carbonate saturated with carbon dioxide and hydrogen sulfide is cited. The corrosion of carbon steel in a carbonate solution saturated with carbon dioxide can be eliminated with a 0.2 percent concentration of either potassium chromate or sodium metavanadate. In solutions of carbonate saturated with carbon dioxide and hydrogen sulfide no corrosion is obtained with 0.2 percent sodium metavanadate or 0.15 percent vanadium pentoxide. The alkaline-sulfide mixture destroys oxidizing inhibitors such as potassium chromate. N-alkyl trimethylene diamines at a concentration of 0.1 percent reduce the corrosion rate to about 5 mpy. Sodium metasilicate, at a concentration of 0.6 percent, completely inhibits the corrosion, but deposits free silica in the system. Commercially available cladding materials such as the epoxy-coatings also prevent corrosion. 5.8.2, 6.2.3
Synthesis of Nitric Oxide-Releasing Gold Nanoparticles (2005)

We report the synthesis of nitric oxide-releasing gold nanoparticles formed by place-exchange reaction of hexanethiol monolayer-protected clusters with diamine nitric oxide donor precursor molecules, which are subsequently converted to N-diazeniumdiolate NO donors. The nitric oxide release from the N-diazeniumdiolate-modified gold nanoparticles is tunable by varying the number and/or the chemical structure of the exchanged amine ligands. The size and stability of NO-releasing nanoparticles may prove useful for a range of biomedical and pharmaceutical applications.
BRAF Mutations in Advanced Cancers: Clinical Characteristics and Outcomes (2011)

BRAF appears to be a druggable mutation that also defines subgroups of patients with phenotypic overlap, albeit with differences that correlate with histology or site of mutation.
Development of Multifunctional Hyaluronan-Coated Nanoparticles for Imaging and Drug Delivery to Cancer Cells (2012)

Currently, there is high interest in developing multifunctional theranostic platforms for cancer monitoring and chemotherapy. Herein, we report hyaluronan (HA)-coated superparamagnetic iron oxide nanoparticles (HA-SPION) as a promising system for targeted imaging and drug delivery. When incubated with cancer cells, HA-SPIONs were rapidly taken up and the internalization of HA-SPION by cancer cells was much higher than the NPs without HA coating. The high magnetic relaxivity of HA-SPION coupled with enhanced uptake enabled magnetic resonance imaging of cancer cells. Furthermore, doxorubicin (DOX) was attached onto the nanoparticles through an acid responsive linker. While HA-SPION was not toxic to cells, DOX-HA-SPION was much more potent than free DOX to kill not only drug-sensitive but also multi-drug-resistant cancer cells. This was attributed to differential uptake mechanisms and cellular distributions of free DOX and DOX-HA-SPION in cancer cells.
Studies on chemical constituents and immunological function activity of hairy root of Astragalus membranaceus. (1998)

Using a large-scale culture technique, the hairy roots of Astragalus membranaceus were produced with a yield reaching 10 g/L. The results from RP-HPLC detection showed that the contents of crude saponin and astragaloside i.v. in the hairy roots were 5.81% and 0.14%, respectively. Six isoflavonoid compounds were also determined. Polysaccharide analysis showed that the total polysaccharide content in the hairy roots was 22.97%; of this content, acidic 8.29% and soluble 14.88%. In comparison with the dry roots, the hairy roots contained higher crude saponin and soluble polysaccharide contents, similar astragaloside i.v. content and lower contents of 6 isoflavonoids, total and acidic polysaccharides, showing that the quality of both types of roots was similar. Regaining the immunity function of rats with low immunity after feeding the aqueous extract of the hairy roots produced by large-scale culture showed that its capacity was similar to the dry roots of A. membranaceus in increasing the immunity function. The results in this paper give evidence that the hairy roots may be a new source of A. membranaceus.