gebhart/patrepeval huggingface dataset:
Evaluation of a monoclonal immunoradiometric assay for prostate-specific antigen. (1987)

We evaluated the analytical performance of a new monoclonal immunoradiometric assay ("M-PSA") for prostate-specific antigen ("Tandem"; Hybritech Inc.) in comparison with a monoclonal immunoradiometric assay ("M-PAP") for mass measurement of prostatic acid phosphatase ("Tandem") and with a conventional enzyme-activity assay ("E-PAP") for prostatic acid phosphatase (EC 3.1.3.2). For M-PSA, the CVs were 1.3-3.0% within-run and 3.0-4.9% between-run. The minimum detectable mass concentration was 0.10 microgram/L, and linearity extended to 100 micrograms/L. The reference interval for M-PSA in 178 healthy men was 0-2.8 micrograms/L. Serum specimens from men with prostatic disease (primarily prostatic carcinoma and benign prostatic hypertrophy) were assayed by the three methods. Correlation was best between mass measurement (M-PAP) and enzyme activity (E-PAP) for prostatic acid phosphatase (r = 0.958). Results for PSA did not correlate well with those for either M-PAP (r = 0.629) or E-PAP (r = 0.387). PSA was increased in a higher percentage of specimens from men with earlier (clinical stage B) prostatic carcinoma than were results from either assay for PAP.
Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes (1999)

In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar H2O2 concentrations display impaired insulin stimulated GLUT4 translocation from internal membrane pools to the plasma membrane (Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kannety, H., and Bashan, N. (1998) Diabetes 47, 1562-1569). In this study we further characterize the cellular mechanisms responsible for this observation. Two-hour exposure to approximately 25 microM H2O2 (generated by adding glucose oxidase to the medium) resulted in disruption of the normal insulin stimulated insulin receptor substrate (IRS)-1 and phosphatidylinositol (PI) 3-kinase cellular redistribution between the cytosol and an internal membrane pool (low density microsomal fraction (LDM)). This was associated with reduced insulin-stimulated IRS-1 and p85-associated PI 3-kinase activities in the LDM (84 and 96% inhibition, respectively). The effect of this finding on the downstream insulin signal was demonstrated by a 90% reduction in insulin stimulated protein kinase B (PKB) serine 473 phosphorylation and impaired activation of PKBalpha and PKBgamma. Both control and oxidized cells exposed to heat shock displayed a wortmannin insensitive PKB serine phosphorylation and activity. These data suggest that activation of PKB and GLUT4 translocation are insulin signaling events dependent upon a normal insulin induced cellular compartmentalization of PI 3-kinase and IRS-1, which is oxidative stress-sensitive. These findings represent a novel cellular mechanism for the induction of insulin resistance in response to changes in the extracellular environment.
Inducing an Incipient Terahertz Finite Plasmonic Crystal in Coupled Two Dimensional Plasmonic Cavities (2012)

We measured a change in the current transport of an antenna-coupled, multigate, GaAs/AlGaAs field-effect transistor when terahertz electromagnetic waves irradiated the transistor and attribute the change to bolometric heating of the electrons in the two dimensional electron channel. The observed terahertz absorption spectrum indicates coherence between plasmons excited under adjacent biased device gates. The experimental results agree quantitatively with a theoretical model we developed that is based on a generalized plasmonic transmission line formalism and describes an evolution of the plasmonic spectrum with increasing electron density modulation from homogeneous to the crystal limit. These results demonstrate an electronically induced and dynamically tunable plasmonic band structure.
Digital receivers and transmitters using polyphase filter banks for wireless communications (2003)

Provides a tutorial overview of multichannel wireless digital receivers and the relationships between channel bandwidth, channel separation, and channel sample rate. The overview makes liberal use of figures to support the underlying mathematics. A multichannel digital receiver simultaneously down-converts a set of frequency-division-multiplexed (FDM) channels residing in a single sampled data signal stream. In a similar way, a multichannel digital transmitter simultaneously up-converts a number of baseband signals to assemble a set of FDM channels in a single sampled data signal stream. The polyphase filter bank has become the architecture of choice to efficiently accomplish these tasks. This architecture uses three interacting processes to assemble or to disassemble the channelized signal set. In a receiver, these processes are an input commutator to effect spectral folding or aliasing due to a reduction in sample rate, a polyphase M-path filter to time align the partitioned and resampled time series in each path, and a discrete Fourier transform to phase align and separate the multiple baseband aliases. In a transmitter, these same processes operate in a related manner to alias baseband signals to high order Nyquist zones while increasing the sample rate with the output commutator.
Compound sensory action potential in normal and pathological human nerves (2003)

The compound sensory nerve action potential (SNAP) is the result of phase summation and cancellation of single fiber potentials (SFAPs) with amplitudes that depend on fiber diameter, and the amplitude and shape of the SNAP is determined by the distribution of fiber diameters. Conduction velocities at different conduction distances are determined by summation of SFAPs of varying fiber diameters, and differ in this respect, also, from the compound muscle action potential (CMAP) for which conduction velocities are determined by the very fastest fibers in the nerve. The effect and extent of temporal dispersion over increasing conduction distance is greater for the SNAP than CMAP, and demonstration of conduction block is therefore difficult. In addition, the effect of temporal dispersion on amplitude and shape is strongly dependent on the number of conducting fibers and their distribution, and, with fiber loss or increased conduction velocity variability changes of the SNAP may be smaller than expected from normal nerve. The biophysical characteristics of sensory and motor fibers differ, and this may to some extent determine divergent pathophysiological changes in sensory and motor fibers in different polyneuropathies. In this review, different factors that characterize sensory fibers and set the SNAP apart from the CMAP are discussed to emphasize the supplementary and complementary information that can be obtained from sensory conduction studies. Sensory conduction studies require particular effort and attention to theory and practical detail that may be time consuming.
Investigating the Hydrogen-Bonding Model of Urea Denaturation (2009)

The direct binding mechanism for urea-based denaturation of proteins was tested with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAM). Thermodynamic measurements of the polymer's hydrophobic collapse were complemented by Fourier transform infrared (FTIR) spectroscopy, Stokes radius measurements, and methylated urea experiments. It was found that the lower critical solution temperature (LCST) of PNIPAM decreased as urea was added to the solution. Therefore, urea actually facilitated the hydrophobic collapse of the macromolecule. Moreover, these thermodynamic measurements were strongly correlated with amide I band data which indicated that the decrease in the LCST was coupled to the direct hydrogen bonding of urea to the amide moieties of the polymer. In addition, the hydrogen bonding was found to be highly cooperative, which is consistent with a cross-linking (bivalent binding) mechanism. Cross-linking was confirmed by Stokes radius measurements below the polymer's LCST using gel filtration chromatography. Finally, phase transition measurements with methylurea, dimethylurea, and tetramethylurea indicated that these substituted compounds caused the LCST of PNIPAM to rise with increasing methyl group content. No evidence could be found for the direct binding of any of these methylated ureas to the polymer amide moieties by FTIR. These results are inconsistent with a direct hydrogen-bonding mechanism for the urea-induced denaturation of proteins.
Independent Validation of a Model Using Cell Line Chemosensitivity to Predict Response to Therapy (2013)

Model predictions were better than chance in all three datasets. However, these scores added little to existing clinical predictors; statistically significant contributions were likely to be too small to change clinical practice. These findings suggest that discovering better predictors will require both cell line data and a clinical training dataset of patient samples.
Invasive group A streptococcal infections in children with varicella in Southern California (1996)

Invasive GAS disease, including streptococcal toxic shock-like syndrome, is a serious complication of varicella. Physicians should be alert for the complication of GAS when fever and localized swelling or signs of cellulitis develop 3 days or more after the onset of varicella. Widespread use of varicella vaccine may decrease invasive GAS infections in this setting.
Recent Progress in the Development of Few Mode Fiber Amplifiers (2015)

We review the performances of both core and cladding pumped few-mode erbium doped fiber amplifiers supporting 6 spatial modes (4 mode groups) which incidentally the highest mode count demonstrated to date.
Support vector machine techniques for nonlinear equalization (2000)

The emerging machine learning technique called support vector machines is proposed as a method for performing nonlinear equalization in communication systems. The support vector machine has the advantage that a smaller number of parameters for the model can be identified in a manner that does not require the extent of prior information or heuristic assumptions that some previous techniques require. Furthermore, the optimization method of a support vector machine is quadratic programming, which is a well-studied and understood mathematical programming technique. Support vector machine simulations are carried out on nonlinear problems previously studied by other researchers using neural networks. This allows initial comparison against other techniques to determine the feasibility of using the proposed method for nonlinear detection. Results show that support vector machines perform as well as neural networks on the nonlinear problems investigated. A method is then proposed to introduce decision feedback processing to support vector machines to address the fact that intersymbol interference (ISI) data generates input vectors having temporal correlation, whereas a standard support vector machine assumes independent input vectors. Presenting the problem from the viewpoint of the pattern space illustrates the utility of a bank of support vector machines. This approach yields a nonlinear processing method that is somewhat different than the nonlinear decision feedback method whereby the linear feedback filter of the decision feedback equalizer is replaced by a Volterra filter. A simulation using a linear system shows that the proposed method performs equally to a conventional decision feedback equalizer for this problem.
Activin receptor antagonists for cancer-related anemia and bone disease (2012)

Sotatercept is a novel receptor fusion protein that functions as a soluble trap to sequester ligands of activin receptor type IIA (ActRIIA). Preclinically, the murine version of sotatercept increased red blood cells (RBC) in a model of chemotherapy-induced anemia, inhibited tumor growth and metastasis, and exerted anabolic effects on bone in diverse models of multiple myeloma. Clinically, sotatercept increases RBC markedly in healthy volunteers and patients with multiple myeloma. With a rapid onset of action differing from erythropoietin, sotatercept is in clinical development as a potential first-in-class therapeutic for cancer-related anemia, including those characterized by ineffective erythropoiesis as in myelodysplastic syndromes. Anabolic bone activity in early clinical studies and potential antitumor effects make sotatercept a promising therapeutic candidate for multiple myeloma and malignant bone diseases. Antitumor activity has been observed preclinically with small-molecule inhibitors of transforming growth factor-β receptor type I (ALK5) that also antagonize the closely related activin receptors ALK4 and ALK7. LY-2157299, the first such inhibitor to enter clinical studies, has shown an acceptable safety profile so far in patients with advanced cancer. Together, these data identify activin receptor antagonists as attractive therapeutic candidates for multiple diseases.
A Novel GRISM-Based Probe for Spectrally Encoded Confocal Microscopy (2002)

A device capable of performing endoscopic confocal microscopy could potentially provide physicians with a tool for performing in vivo, non-invasive, subcellular diagnostic imaging. Recently, a novel, sub-micrometer resolution, spectrally encoded confocal microscopy (SECM) imaging system has been presented. It incorporates a quasimonochromatic light source and a diffraction grating to simultaneously detect the reflectivity at multiple points along a transverse line within the sample. Since this method does not require fast spatial scanning within the probe, it is capable of being miniaturized and incorporated into a catheter or endoscope. The work in this abstract demonstrates a novel design for a 10 mm diameter SECM probe, based on a double prism GRISM, which can be used laparoscopically. Furthermore, this design can be scaled without significant modification to less than 5 mm to allow integration with large bore endoscopes.
Systemic interleukin 2 therapy for human prostate tumors in a nude mouse model. (1998)

Once the regional lymph nodes become involved in prostate carcinoma, 85% of patients develop distant metastases within 5 years, and metastatic disease is difficult to treat. We have investigated the effect of systemic interleukin 2 (IL-2) treatment on metastatic prostate carcinoma using a xenograft tumor model. Cells from a PC-3/IF cell line, produced by intrafemoral injection of human PC-3 prostate carcinoma cells, were injected in the prostate of Balb/c nude mice. Prostate tumors and para-aortic lymph nodes were resected, and tumor cells were recultured and passaged in the prostate in vivo to produce new cell lines. On day 6 following prostatic injection of these cell lines, mice were treated with i.p. injections of IL-2 at 25,000-50,000 units/ day for 5 consecutive days. The effect of IL-2 on tumor progression was assessed, and histological studies were performed on prostate tumor and lymph node sections. The tumor cell lines generated by serial prostate injection were tumorigenic and metastasized to regional para-aortic lymph nodes. Tumors of 0.4 cm were obtained by day 16 and grew to 1-1.5 cm by day 40 with metastasis to para-aortic lymph nodes. Following two to three weekly courses of 5 days of 25,000-40,000 units/day of IL-2, the growth of prostate tumors was inhibited by 94%. Higher doses of 50,000 units/ day were toxic. Histologically, prostate sections showed vascular damage manifested by multifocal hemorrhages and an influx of lymphocytes and polymorphonuclear cells into disintegrating tumors and areas of necrosis containing numerous apoptotic cells. In contrast to control mice, para-aortic lymph nodes were not enlarged in responding mice. These findings suggest that systemic IL-2 therapy can induce an antitumor response in prostate tumors and control their growth and metastasis.
A Summary of the X.500(96) User Schema for use with LDAPv3 (1997)

This document provides an overview of the attribute types and object classes defined by the ISO and ITU-T committees in the X.500 documents, in particular those intended for use by directory clients. This is the most widely used schema for LDAP/X.500 directories, and many other schema definitions for white pages objects use it as a basis. This document does not cover attributes used for the administration of X.500 directory servers, nor does it include attributes defined by other ISO/ITU-T documents.
C-Reactive Protein and Antibacterial Activity in Blood Plasma of Colostrum-Fed Calves and the Effect of Lactulose (2003)

Several milk proteins are very important for immunological defense and can be absorbed in the intestine of calves in the first hours after birth. The influence of colostrum intake and the effect of additional lactulose application on the concentration of C-reactive protein (CRP) in blood were investigated. The CRP is known as a mediator of innate immunity. Results were compared to the bovine acute phase protein haptoglobin, and to lactalbumin, lactoferrin, and immunoglobulins in plasma from calves. After colostrum intake, the concentration of most proteins were strongly increased. The data show, for the first time, a significant increase of CRP in the blood of calves 1 d after colostrum intake (nonlactulose group, n = 10), and an even more significant increase in CRP concentration (1 d postpartum) was measured in the group of animals with additional application of lactulose (lactulose group, n = 10) when compared to the nonlactulose group. In an in vitro assay with the plasma of these animals, an increased bactericidal activity was detected against Morganella morganii (1 d postpartum) in both groups, but again a higher activity occurred in the lactulose group. The results of these investigations emphasize the importance of colostrum intake during the first hours after birth for the defense potential of newborn calves. In addition, lactulose may have a positive effect in the period of passive transfer of colostrum proteins and in the immune defense.
Querying and mining of time series data (2008)

The last decade has witnessed a tremendous growths of interests in applications that deal with querying and mining of time series data. Numerous representation methods for dimensionality reduction and similarity measures geared towards time series have been introduced. Each individual work introducing a particular method has made specific claims and, aside from the occasional theoretical justifications, provided quantitative experimental observations. However, for the most part, the comparative aspects of these experiments were too narrowly focused on demonstrating the benefits of the proposed methods over some of the previously introduced ones. In order to provide a comprehensive validation, we conducted an extensive set of time series experiments re-implementing 8 different representation methods and 9 similarity measures and their variants, and testing their effectiveness on 38 time series data sets from a wide variety of application domains. In this paper, we give an overview of these different techniques and present our comparative experimental findings regarding their effectiveness. Our experiments have provided both a unified validation of some of the existing achievements, and in some cases, suggested that certain claims in the literature may be unduly optimistic.
Modeling Tau Polymerization in Vitro:  A Review and Synthesis (2003)

The major antigenic component of neurofibrillary pathology in a large number of neurodegenerative diseases consists of the microtubule-associated protein tau. It is currently unclear how tau protein makes the transition from an important component of the microtubule-based cytoskeleton to an insoluble polymerized state. In vitro techniques have been employed to study the polymerization of tau in an effort to understand the underlying molecular mechanisms responsible for this process. These efforts have resulted in the elucidation of roles played by the different parts of the molecule in the polymerization process. Here we discuss the advantages and disadvantages of the various techniques used to model tau polymerization and the discoveries arising from these techniques that have led to a better structural understanding of tau polymerization in relation to Alzheimer's disease and other tauopathies.
C 4 -Dicarboxylate Degradation in Aerobic and Anaerobic Growth (2004)

C4-dicarboxylates, like succinate, fumarate, L- and D-malate, tartrate, and the C4-dicarboxylic amino acid aspartate, support aerobic and anaerobic growth of Escherichia coli and related bacteria and can serve as carbon and energy sources. In aerobic growth, the C4-dicarboxylates are oxidized in the citric acid cycle. Due to the interruption of the citric acid cycle under anaerobic conditions, anaerobic metabolism of the C4-dicarboxylates depends on fumarate reduction to succinate. In some related bacteria (e.g., Klebsiella), degradation of C4-dicarboxylates, like tartrate, uses a different mechanism and pathway. It requires the functioning of an Na+-dependent and membrane-associated oxaloacetate decarboxylase. Due to the incomplete function of the citric acid cycle in anaerobic growth, succinate supports only aerobic growth of E. coli. This chapter describes the pathways of and differences in aerobic and anaerobic C4-dicarboxylate metabolism and the physiological consequences. The citric acid cycle, fumarate respiration, and fumarate reductase are discussed here only in the context of aerobic and anaerobic C4-dicarboxylate metabolism. Some recent aspects of C4-dicarboxylate metabolism, such as transport and sensing of C4-dicarboxylates, and their relationships are treated in more detail.
Heat-Treated Transition Metal Hexacyanometallates as Electrocatalysts for Oxygen Reduction Insensitive to Methanol (2004)

Highly active catalysts for electrochemical reduction of oxygen insensitive to the presence of methanol were prepared from transition metal hexacyanometallate precursors by heat-treatment with carbon black under an inert atmosphere. The catalytic activity for oxygen reduction was examined with the floating electrode technique under an air atmosphere at room temperature. The electrolyte used in most of the measurements was 1 M sodium phosphate buffer solution (pH 7.5), whereas acid and alkaline solutions were also used in addition to the neutral buffer solution to examine the catalytic activity of the prepared catalyst over a wide range of pH. Remarkable enhancements in the catalytic activity were observed for samples heat-treated at temperatures higher than 500°C. Among several 3d-transition metals incorporated in the inorganic precursor, the combination of cobalt and iron incorporated at neighboring sites gave the highest activity, comparable to that of platinum black catalyst (Pt/C). The catalytic activity for oxygen reduction was not affected by the presence of 2.5 M methanol in the electrolyte, while that of Pt/C was severely impaired by the presence of methanol. The catalysts prepared from the inorganic precursors were characterized by X-ray diffraction (XRD), infrared (IR), and X-ray photoelectron spectroscopy (XPS) measurements. The XRD and IR data indicated that the cyanide structure of the inorganic precursor was decomposed when heating beyond 500°C. The XPS data indicated that the oxidation states of cobalt and iron are close to metallic ones and two types of nitrogen forming new bonding are present in the heat-treated samples. The same structural and spectral changes were observed for samples heat-treated without carbon black. From these results, the evolution of the high catalytic activity by heat-treating the inorganic precursors is discussed. © 2004 The Electrochemical Society. All rights reserved.