gebhart/patrepeval huggingface dataset:
Direct Detection and Quantification of Transition Metal Ions in Human Atherosclerotic Plaques: Evidence for the Presence of Elevated Levels of Iron and Copper (2004)

These data support the hypothesis that iron accumulates in human lesions and may contribute to disease progression.
Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency (2009)

Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable. (ClinicalTrials.gov number, NCT00520780).
Adipositas: Inflammation im viszeralen Fettgewebe (2010)

Metabolic syndrome/adiposity as a global problem. High risk to develope diabetes mellitus 2 and atherosclerosis. Relation between adiposity and inflammatory cells in visceral adipose tissue. Difference between diabetics and non-diabetics. CD-4 positive T-lymphocytes, CD-68 (macrophages), CD-31 (endothelial cells) and HLA-DR positive cells are detectable in human visceral adipose tissue. CD-4 positive T-lymphocytes as a possible new therapy-method in adiposity.
Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). (1994)

Intensive multifactor risk reduction conducted over 4 years favorably altered the rate of luminal narrowing in coronary arteries of men and women with coronary artery disease and decreased hospitalizations for clinical cardiac events.
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells (2013)

Significant advances in cellular reprogramming technologies and hematopoietic differentiation from human pluripotent stem cells (hPSCs) have already enabled the routine production of multiple lineages of blood cells in vitro and opened novel opportunities to study hematopoietic development, model genetic blood diseases, and manufacture immunologically matched cells for transfusion and cancer immunotherapy. However, the generation of hematopoietic cells with robust and sustained multilineage engraftment has not been achieved. Here, we highlight the recent advances in understanding the molecular and cellular pathways leading to blood development from hPSCs and discuss potential approaches that can be taken to facilitate the development of technologies for de novo production of hematopoietic stem cells.
Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor (1991)

We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage-dependent and anchorage-independent growth of U-87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF receptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development of these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization of basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors.
GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis (2009)

G protein-coupled receptor 119 (GPR119) is expressed in pancreatic islets and intestine, and is involved in insulin and incretin hormone release. GPR119-knockout (Gpr119(-/-)) mice were reported to have normal islet morphology and normal size, body weight (BW), and fed/fasted glucose levels. However, the physiological function of GPR119 and its role in maintaining glucose homeostasis under metabolic stress remain unknown. Here, we report the phenotypes of an independently generated line of Gpr119(-/-) mice under basal and high-fat diet (HFD)-induced obesity. Under low-fat diet feeding, Gpr119(-/-) mice show normal plasma glucose and lipids, but have lower BWs and lower post-prandial levels of active glucagon-like peptide 1 (GLP-1). Nutrient-stimulated GLP-1 release is attenuated in Gpr119(-/-) mice, suggesting that GPR119 plays a role in physiological regulation of GLP-1 secretion. Under HFD-feeding, both Gpr119(+)(/)(+) and Gpr119(-/-) mice gain weight similarly, develop hyperinsulinemia and hyperleptinemia, but not hyperglycemia or dyslipidemia. Glucose and insulin tolerance tests did not reveal a genotypic difference. These data show that GPR119 is not essential for the maintenance of glucose homeostasis. Moreover, we found that oleoylethanolamide (OEA), reported as a ligand for GPR119, was able to suppress food intake in both Gpr119(+)(/)(+) and Gpr119(-/-) mice, indicating that GPR119 is not required for the hypophagic effect of OEA. Our results demonstrate that GPR119 is important for incretin and insulin secretion, but not for appetite suppression.
On the Existence of a Surface Wave in Dipole Radiation over a Plane Earth (1950)

In a paper published in 1909, Sommerfeld stated the existence of a surface-type wave in the radiation of a vertical Hertzian dipole over a plane earth. Weyl, in 1919, objected to this solution. Despite a great number of papers on this problem, it had not been definitively settled so far. Its solution is given in the present paper by proving in a quite general way that this surface wave cannot be included in the said dipole radiation and by pointing out a thusfar hidden error in Sommerfeld's computation.
Designing interfaces: patterns for effective interaction design (2005)

This convenient resource offers advice on creating user-friendly interface designs--whether they're delivered on the Web, a CD, or a smart&amp;amp;quot; devices like a cell phone. Solutions to common UI design problems are expressed as a collection of patterns--each one containing concrete examples, recommendations, and warnings. Intended for designers with basic UI design knowledge
In Vivo Treatment with a MHC Class I-Restricted Blocking Peptide Can Prevent Virus-Induced Autoimmune Diabetes (1998)

We tested the in vivo potential of a MHC class I-restricted blocking peptide to sufficiently lower an anti-viral CTL response for preventing virus-induced CTL-mediated autoimmune diabetes (insulin-dependent diabetes mellitus (IDDM)) in vivo without affecting systemic viral clearance. By designing and screening several peptides with high binding affinities to MHC class I H-2Db for best efficiency in blocking killing of target cells by lymphocytic choriomeningitis virus (LCMV) and other viral CTL, we identified the peptide for this study. In vitro, it selectively lowered CTL killing restricted to the Db allele, which correlated directly with the affinity of the respective epitopes. Expression of the blocking peptide in the target cell lowered recognition of all Db-restricted LCMV epitopes. In addition, in vitro expansion of LCMV memory CTL was prevented, resulting in decreased IFN-gamma secretion. In vivo, a 2-wk treatment with this peptide lowered the LCMV Db-restricted CTL response by over threefold without affecting viral clearance. However, the CTL reduction by the peptide treatment was sufficient to prevent LCMV-induced IDDM in rat insulin promoter-LCMV-glycoprotein transgenic mice. Following LCMV infection, these mice develop IDDM, which depends on Db-restricted anti-self (viral) CTL. Precursor numbers of splenic LCMV-CTL in peptide-treated mice were reduced, but their cytokine profile was not altered, indicating that the peptide did not induce regulatory cells. Further, non-LCMV-CTL recognizing the blocking peptide secreted IFN-gamma and did not protect from IDDM. This study demonstrates that in vivo treatment with a MHC class I blocking peptide can prevent autoimmune disease by directly affecting expansion of autoreactive CTL.
Structure-Activity Studies of the Binding of Modified Peptide Nucleic Acids (PNAs) to DNA (1994)

Peptide nucleic acid (PNA) oligomers where one of the repeating backbone units is extended with a methylene group to either N-(2-aminoethyl)-beta-alanine or N-(3-aminopropyl)glycine were prepared. Alternatively, the linker to the nucleobase was extended from methylenecarbonyl to ethylenecarbonyl. The thermal stability of the hybrids between these PNA oligomers and complementary DNA oligonucleotides was significantly lower than that of the corresponding complexes involving unmodified PNA. However, the sequence selectivity was retained. Thymidyl decamers with all N-(2-aminoethyl)-beta-alanine or N-(3-aminopropyl)glycine backbones were prepared and shown to be unable to hybridize to the complementary (dA)(10) oligonucleotides, whereas a PNA decamer containing only ethylenecarbonyl linkers between the nucleobases and the N-(2-aminoethyl)glycine backbone showed weak but sequence-specific affinity for complementary DNA. All hybrids involving homopyrimidine PNA oligomers exhibited (PNA)(2)/DNA stoichiometry, whereas mixed-sequence PNA oligomers formed PNA/DNA duplexes. The preferred binding direction between the modified PNA and DNA in the duplex motifs was antiparallel, as previously reported for complexes involving unmodified PNA.
Streaming data integration: Challenges and opportunities (2010)

In this position paper, we motivate the need for streaming data integration in three main forms including across multiple streaming data sources, over multiple stream processing engine instances, and between stream processing engines and traditional database systems. We argue that this need presents a broad range of challenges and opportunities for new research. We provide an overview of the young state of the art in this area and further discuss a selected set of concrete research topics that are currently under investigation within the scope of our MaxStream federated stream processing project at ETH Zurich.
Protein expression and glycosylation in CHO cells (2001)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2001.
A Conformation-Specific Monoclonal Antibody Reacting with Fusion-Active gp41 from the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein (1998)

The gp41 subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein plays a major role in the membrane fusion step of viral infection. The ectodomain of gp41 contains a six-helix structural domain that likely represents the core of the fusion-active conformation of the molecule. A monoclonal antibody (MAb), designated NC-1, was generated and cloned from a mouse immunized with the model polypeptide N36(L6)C34, which folds into a stable six-helix bundle. NC-1 binds specifically to both the alpha-helical core domain and the oligomeric forms of gp41. This conformation-dependent reactivity is dramatically reduced by point mutations within the N-terminal coiled-coil region of gp41 which impede formation of the gp41 core. NC-1 binds to the surfaces of HIV-1-infected cells only in the presence of soluble CD4. These results indicate that NC-1 is capable of reacting with fusion-active gp41 in a conformation-specific manner and can be used as a valuable biological reagent for studying the receptor-induced conformational changes in gp41 required for membrane fusion and HIV-1 infection.
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction (2000)

Administration of JAK2 inhibitor resulted in deterioration of myocardial viability in AMI hearts. The JAK/STAT pathway is activated in AMI myocardium and plays a pivotal role in cytoprotective signaling.
Immunotherapy with the trifunctional anti‐CD20 x anti‐CD3 antibody FBTA05 (Lymphomun) in paediatric high‐risk patients with recurrent CD20‐positive B cell malignancies (2014)

Children with B cell malignancies refractory to standard therapy are known to have a poor prognosis and very limited treatment options. Here, we report on the treatment and follow-up of ten patients diagnosed with relapsed or refractory mature B-cell Non Hodgkin Lymphoma (B-NHL), Burkitt leukaemia (B-AL) or pre B-acute lymphoblastic leukaemia (pre B-ALL). All children were treated with FBTA05 (now designated Lymphomun), an anti-CD3 x anti-CD20 trifunctional bispecific antibody (trAb) in compassionate use. Within individual treatment schedules, Lymphomun was applied (a) after allogeneic stem cell transplantation (allo-SCT, n = 6) to induce sustained long-term remission, or (b) stand alone prior to subsequent chemotherapy to eradicate residual disease before allo-SCT (n = 4). Nine of ten children displayed a clinical response: three stable diseases (SD), one partial remission (PR) and five induced or sustained complete remissions (CR). Five of these nine responders died during follow-up. The other patients still maintain CR with a current overall survival of 874-1424 days (median: 1150 days). In conclusion, despite the dismal clinical prognosis of children refractory to standard therapy, immunotherapy with Lymphomun resulted in a favourable clinical outcome in this cohort of refractory paediatric patients.
Coherent Control for Spectroscopy and Manipulation of Biological Dynamics (2005)

Motivated originally by the goal of steering a photoreaction into desired product channels, the concept of coherent control is to adapt the spectral and temporal characteristics of the excitation light to the inherent molecular resonances and dynamics, such that these can be selectively addressed and manipulated. In the last decade, the ultrafast dynamics of many atomic and molecular quantum systems in the gas and condensed phase have been controlled successfully. Motivations in chemistry are now 1) to perform spectroscopy by coherent control, which requires a deeper understanding of control mechanisms, 2) to treat more complex, biological photoreactions, and 3) the pragmatic use of coherent control techniques, for example, for pulse compression or enhanced contrast in multiphoton microscopy. As examples for 1) and 2) we review here the combined effort and interplay of conventional spectroscopy and coherent control experiments, applied to the energy flow in the light-harvesting complex LH2 from bacterial photosynthesis. Closed-loop control experiments allowed the characteristic coupling frequency of internal conversion in the carotenoid in LH2 to be extracted. Open-loop three-pulse control experiments, on the other hand, could directly observe an anticipated Raman-excited carotenoid ground state. As a variant of difference spectroscopy, coherent control has thus served to gain complementary spectroscopic knowledge about the energy flow in carotenoids by comparing natural to manipulated dynamics. Finally, we propose future coherent control experiments on the electronic state structure of carotenoids and discuss prospects of coherent control for other biological chromophores.
Pitfalls in the use of interference screws for anterior cruciate ligament reconstruction: Brief report (1989)

Arthroscopically assisted bone patellar tendon bone reconstruction of the anterior cruciate ligament (ACL) is becoming an increasingly popular surgical technique. Use of interference screw fixation of the bone plugs within bony tunnels has been shown to improve fixation and pull-out strength. Several potential pitfalls exist which can jeopardize results of the surgical procedure when this form of fixation is used. This article describes the potential pitfalls and suggests methods to avoid them.
Effect of observer metamerism on colour matching of display and surface colours (2008)

Abstract We studied the individual variability of asymmetric metameric colour matching between computer displays and object colour stimuli in conditions typical for the surface colour industries. Using two different computational techniques, we assessed the contribution of observer metamerism to this variability. In the studied conditions of spatially separated computer display and surface colour stimuli, this contribution was found to be insignificant for all colours but neutrals. In the chromaticness plane, the range of matches made by different observers practically coincides with the range of matches made by an individual observer. Consequently, we conclude that in the task of matching spatially separated display and surface colours, the range of matches made by a group of observers cannot be determined from variations in their colour‐matching functions, and thus the paradigm of the Standard Deviate Observer is shown to be inapplicable to the studied conditions. We suggest that individual variability in these conditions is governed by mechanisms of chromatic discrimination, and can be modeled by advanced colour difference formulae with suitably adjusted parametric coefficients. © 2008 Wiley Periodicals, Inc. Col Res Appl, 33, 346–359, 2008
Nucleic acid and related compounds. 75. Synthesis and radical-induced ring-opening reactions of 2'-deoxyadenosine-2'-spirocyclopropane and its uridine analogs. Mechanistic probes for ribonucleotide reductases (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNucleic acid and related compounds. 75. Synthesis and radical-induced ring-opening reactions of 2'-deoxyadenosine-2'-spirocyclopropane and its uridine analogs. Mechanistic probes for ribonucleotide reductasesVicente Samano and Morris J. RobinsCite this: J. Am. Chem. Soc. 1992, 114, 10, 4007–4008Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://doi.org/10.1021/ja00036a077RIGHTS & PERMISSIONSArticle Views307Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (327 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen. (1988)

The carboxy-terminal tail of nucleoplasmin, which specifies entry into the cell nucleus, contains four short sequences that are similar to previously identified nuclear location sequences. We show that none of these is able to locate chicken muscle pyruvate kinase to the cell nucleus. Deletion analysis was used to determine the limits of a nuclear location sequence and indicated that a 14-amino acid segment (RPAATKKAGQAKKK) should function as a minimal nuclear location sequence. When tested directly, however, this sequence was unable to locate pyruvate kinase to the cell nucleus. Restoration of three amino acids of nucleoplasmin sequence at either end of this sequence generated sequences that were able to locate pyruvate kinase to the cell nucleus. The 14-amino acid proposed minimal nuclear location sequence is present in the functional sequences, AVKRPAATKKAGQAKKK, RPAATKKAGQAKKKKLD, and the sequence AVKRPAATKKAGQAKKKKLD, which has additional amino acids at both ends. The minimal sequence element is therefore necessary but not sufficient for transport into the cell nucleus. This unusual feature of the nucleoplasmin nuclear location sequence suggests ways in which it could interact with the nuclear transport mechanism.
Alleviating catastrophic forgetting using context-dependent gating and synaptic stabilization (2018)

Humans and most animals can learn new tasks without forgetting old ones. However, training artificial neural networks (ANNs) on new tasks typically causes them to forget previously learned tasks. This phenomenon is the result of "catastrophic forgetting," in which training an ANN disrupts connection weights that were important for solving previous tasks, degrading task performance. Several recent studies have proposed methods to stabilize connection weights of ANNs that are deemed most important for solving a task, which helps alleviate catastrophic forgetting. Here, drawing inspiration from algorithms that are believed to be implemented in vivo, we propose a complementary method: adding a context-dependent gating signal, such that only sparse, mostly nonoverlapping patterns of units are active for any one task. This method is easy to implement, requires little computational overhead, and allows ANNs to maintain high performance across large numbers of sequentially presented tasks, particularly when combined with weight stabilization. We show that this method works for both feedforward and recurrent network architectures, trained using either supervised or reinforcement-based learning. This suggests that using multiple, complementary methods, akin to what is believed to occur in the brain, can be a highly effective strategy to support continual learning.
The characterization of an alanine racemase mutant ofEscherichia coli (1972)

SUMMARY Among temperature-sensitive mutants of Escherichia coli a strain was discovered requiring D-alanine for growth. It was proved to possess an altered alanine racemase. The structural gene for this enzyme, designated alr , is located between metB and pur A . The properties of the enzyme and its locus suggest that it is not under control of the mechanisms which regulate mucopeptide formation. A suppressor of the alr mutation was discovered near trp , and termed msuA .
Spherical silicon-shell photonic band gap structures fabricated by laser-assisted chemical vapor deposition (2007)

Laser-assisted chemical vapor deposition was applied in fabricating three-dimensional (3D) spherical-shell photonic band gap (PBG) structures by depositing silicon shells covering silica particles, which had been self-assembled into 3D colloidal crystals. The colloidal crystals of self-assembled silica particles were formed on silicon substrates using the isothermal heating evaporation approach. A continuous wave Nd:YAG laser (1064nm wavelength) was used to deposit silicon shells by thermally decomposing disilane gas. Periodic silicon-shell∕silica-particle PBG structures were obtained. By removing the silica particles enclosed in the silicon shells using hydrofluoric acid, hollow spherical silicon-shell arrays were produced. This technique is capable of fabricating structures with complete photonic band gaps, which is predicted by simulations with the plane wave method. The techniques developed in this study have the potential to flexibly engineer the positions of the PBGs by varying both the silica particle size and the silicon-shell thickness. Ellipsometry was used to investigate the specific photonic band gaps for both structures.