gebhart/patrepeval huggingface dataset:
Characterization of the Volatile Constituents in the Essential Oil of Pistacia lentiscus L. from Different Origins and Its Antifungal and Antioxidant Activity (2007)

Essential oil (EO) from aerial parts (leaves, juvenile branches, and flowers when present) of Pistacia lentiscus L. growing wild in five localities of Sardinia (Italy) was extracted by steam-distillation (SD) and analyzed by gas chromatography (GC), FID, and GC-ion trap mass spectrometry (ITMS). Samples of P. lentiscus L. were harvested between April and October to study the seasonal chemical variability of the EO. A total of 45 compounds accounting for 97.5-98.4% of the total EO were identified, and the major compounds were alpha-pinene (14.8-22.6%), beta-myrcene (1-19.4%), p-cymene (1.6-16.2%), and terpinen-4-ol (14.2-28.3%). The yields of EO (v/dry w) ranged between 0.09 and 0.32%. Similar content of the major compounds was found in samples from different origins and seasonal variability was also observed. The EOs were tested for their antifungal activity against Aspergillus flavus, Rhizoctonia solani, Penicillium commune, Fusarium oxysporum. Two samples were weakly effective against Aspergillus flavus. Furthermore, terpinenol and alpha-terpineol, two of the major components of EO of Pistacia lentiscus L., totally inhibited the mycelian growth of A. flavus. Quite good antioxidant activity of the EO was also found.
OpenQoS: An OpenFlow controller design for multimedia delivery with end-to-end Quality of Service over Software-Defined Networks (2012)

OpenFlow is a Software Defined Networking (SDN) paradigm that decouples control and data forwarding layers of routing. In this paper, we propose OpenQoS, which is a novel OpenFlow controller design for multimedia delivery with end-to-end Quality of Service (QoS) support. Our approach is based on QoS routing where the routes of multimedia traffic are optimized dynamically to fulfill the required QoS. We measure performance of OpenQoS over a real test network and compare it with the performance of the current state-of-the-art, HTTP-based multi-bitrate adaptive streaming. Our experimental results show that OpenQoS can guarantee seamless video delivery with little or no video artifacts experienced by the end-users. Moreover, unlike current QoS architectures, in OpenQoS the guaranteed service is handled without having adverse effects on other types of traffic in the network.
Advances in multiplex PCR: balancing primer efficiencies and improving detection success (2012)

<b>1.</b> Multiplex PCR is a valuable tool in many biological studies but it is a multifaceted procedure that has to be planned and optimised thoroughly to achieve robust and meaningful results. In particular, primer concentrations have to be adjusted to assure an even amplification of all targeted DNA fragments. Until now, total DNA extracts were used for balancing primer efficiencies; however, the applicability for comparisons between taxa or different multiple-copy genes was limited owing to the unknown number of template molecules present per total DNA. <b>2.</b> Based on a multiplex system developed to track trophic interactions in high Alpine arthropods, we demonstrate a fast and easy way of generating standardised DNA templates. These were then used to balance the amplification success for the different targets and to subsequently determine the sensitivity of each primer pair in the multiplex PCR. <b>3.</b> In the current multiplex assay, this approach led to an even amplification success for all seven targeted DNA fragments. Using this balanced multiplex PCR, methodological bias owing to variation in primer efficiency will be avoided when analysing field-derived samples. <b>4.</b> The approach outlined here allows comparing multiplex PCR sensitivity, independent of the investigated species, genome size or the targeted genes. The application of standardised DNA templates not only makes it possible to optimise primer efficiency within a given multiplex PCR, but it also offers to adjust and/or to compare the sensitivity between different assays. Along with other factors that influence the success of multiplex reactions, and which we discuss here in relation to the presented detection system, the adoption of this approach will allow for direct comparison of multiplex PCR data between systems and studies, enhancing the utility of this assay type.
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (2015)

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.
Adipose-derived Stem Cells for Tissue Repair and Regeneration: Ten Years of Research and a Literature Review (2009)

Stem cell based therapies for the repair and regeneration of various tissues and organs offer a paradigm shift that may provide alternative therapeutic solutions for a number of diseases. Although embryonic stem cells and induced pluripotent stem cells are theoretically highly beneficial, there are various limitations to their use imposed by cell regulations, ethical considerations, and genetic manipulation. Adult stem cells, on the other hand, are more easily available, with neither ethical nor immunoreactive considerations, as long as they are of autologous tissue origin. Much research has focused on mesenchymal stem cells isolated from bone marrow stroma which have been shown to possess adipogenic, osteogenic, chondrogenic, myogenic, and neurogenic potential in vitro. However bone marrow procurement is extremely painful for patients and yields low numbers of harvested cells. When compared with bone marrow-derived mesenchymal stem cells, adipose-derived stem cells are equally capable of differentiating into cells and tissues of mesodermal origin. Because human adipose tissue is ubiquitous and easily obtainable in large quantities under local anesthesia with little patient discomfort, it may provide an alternative source of stem cells for mesenchymal tissue regeneration and engineering. Based on our previous experimental findings, this review highlights the molecular characteristics, the potential for differentiation, the potential for wound healing, and the future role of adipose-derived stem cells in cell-based therapies and tissue engineering.
The combination of cyclophosphamide and human T cells genetically engineered to target CD19 can eradicate established B‐cell lymphoma (2008)

T cells genetically engineered to express tumour-targeting receptors are attractive anti-cancer therapeutic agents. Human T cells engrafted with a chimeric receptor specific for the B-cell lymphoma antigen CD19 fused to the CD3zeta receptor (aCD19z) are functional in vitro. Current successful clinical protocols targeting melanoma use pre-conditioning chemotherapy in combination with T cells. This study demonstrated that interleukin-2 expanded aCD19z T cells combined with cyclophosphamide effectively treated five-day established Raji B-cell lymphoma in an immunocompromised model system with 50% of mice surviving >100 days. This observation strongly supports the combination of antibody targeted T cells with chemotherapy as a novel approach for the therapy of CD19(+) B-cell malignancies.
Stylization and abstraction of photographs (2002)

Good information design depends on clarifying the meaningful structure in an image. We describe a computational approach to stylizing and abstracting photographs that explicitly responds to this design goal. Our system transforms images into a line-drawing style using bold edges and large regions of constant color. To do this, it represents images as a hierarchical structure of parts and boundaries computed using state-of-the-art computer vision. Our system identifies the meaningful elements of this structure using a model of human perception and a record of a user's eye movements in looking at the photo; the system renders a new image using transformations that preserve and highlight these visual elements. Our method thus represents a new alternative for non-photorealistic rendering both in its visual style, in its approach to visual form, and in its techniques for interaction.
Research of Ground-Penetrating Radar for Detection of Mines and Unexploded Ordnance: Current Status and Research Strategy (1999)

Abstract : This report documents the results of an IDA assessment of the state of research on ground penetrating radar (GPR) as applied to countermine and unexploded ordnance clearance. This report examines existing GPR research and development efforts with emphasis on missions where GPR has the potential to provide a unique capability and to achieve operationally meaningful performance. We identify data collections and analyses that will be necessary both to make decisions about the suitability of GPR for particular missions and to achieve performance gains necessary for operational utility. The potential capabilities of ground penetrating radar could, if realized, make it a useful tool for the detection of mines and UXO. These potential capabilities, however, have not been demonstrated in practice. In most cases, performance is limited by clutter, not by insufficient target signal for detection in noise. Thus, discrimination of targets from clutter is the fundamental problem to be solved to improve GPR target detection performance. Among the numerous research efforts that must be undertaken to advance GPR in any application are soil characterization, discrimination, and modeling. Since it is likely that radar will be paired with another sensor for any application, research to support sensor fusion is important.
[Extracellular matrix, matrix-degrading proteases and vascular calcification]. (2008)

Vascular calcification is a common phenomena among atherosclerosis, diabetes, chronic kidney failure and aging. Recently, extensive researches have shown that the mechanisms of vascular calcification share great similarity with physiological mineralization rather than a passive deposition of calcium and phosphate. As a major component of blood vessels, the extracellular matrix (ECM) proteins not only provide a scaffold for normal vasculature, but also regulate the attachment, proliferation, migration and differentiation of vascular cells through ECM-cell interaction. Furthermore, it also serves as a reservoir for growth factors or cytokines. Previous studies have indicated the potential importance of ECM and ECM degrading proteases during vascular calcification. Extracellular matrix not only provides a major site for calcium and phosphate deposition, but also actively participates in the process of calcification through an accelerating or inhibitory effect. Multiple extracellular matrix proteins have been altered during the calcification. The disturbance of the delicate balance of ECM homeostasis may affect the evolution of vascular calcification. On the other hand, matrix degrading proteases (such as MMPs) may be involved in the occurrence and development of vascular calcification by affecting matrix or non-matrix substances (such as cytokines or growth factors). The current review summarizes the recent advance on vascular calcification in the context of ECM and MMPs.
Congenital Long-QT Syndrome Caused by a Novel Mutation in a Conserved Acidic Domain of the Cardiac Na + Channel (1999)

We characterized the genetics and molecular pathophysiology of a novel SCN5A sodium channel mutation, E1784K. The functional defect exhibited by the mutant channel causes delayed myocardial repolarization, and our data on the effects of multiple charge neutralizations in this region of the C-terminus suggest that the molecular mechanism of channel dysfunction involves an allosteric rather than a direct effect on channel gating.
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma (2007)

The role of B-cell receptor (BCR)-mediated survival signals in diffuse large B-cell lymphoma (DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation, and activation of the spleen tyrosine kinase (SYK), which initiates downstream events and amplifies the initial BCR signal. BCRs also transmit low-level tonic survival signals in the absence of receptor engagement. Herein, we assess the role of SYK-dependent tonic BCR survival signals in DLBCL cell lines and primary tumors and evaluate the efficacy of an ATP-competitive inhibitor of SYK, R406, in vitro. R406 induced apoptosis of the majority of examined DLBCL cell lines. In R406-sensitive DLBCL cell lines, R406 specifically inhibited both tonic- and ligand-induced BCR signaling (autophosphorylation of SYK525/526 and SYK-dependent phosphorylation of the B-cell linker protein [BLNK]). The majority of examined primary DLBCLs also exhibited tonic- and ligand-induced BCR signaling; in these primary tumors, BCR signaling was also inhibited by R406. Of note, BCR-dependent and R406-sensitive DLBCL cell lines were independently identified as "BCR-type" tumors by transcriptional profiling. Therefore, SYK-dependent tonic BCR signaling is an important and potentially targetable survival pathway in some, but not all, DLBCLs. In addition, R406-sensitive DLBCLs can be identified by their transcriptional profiles.
Deep r -th Root of Rank Supervised Joint Binary Embedding for Multivariate Time Series Retrieval (2018)

Multivariate time series data are becoming increasingly common in numerous real world applications, e.g., power plant monitoring, health care, wearable devices, automobile, etc. As a result, multivariate time series retrieval, i.e., given the current multivariate time series segment, how to obtain its relevant time series segments in the historical data (or in the database), attracts significant amount of interest in many fields. Building such a system, however, is challenging since it requires a compact representation of the raw time series which can explicitly encode the temporal dynamics as well as the correlations (interactions) between different pairs of time series (sensors). Furthermore, it requires query efficiency and expects a returned ranking list with high precision on the top. Despite the fact that various approaches have been developed, few of them can jointly resolve these two challenges. To cope with this issue, in this paper we propose a Deep r-th root of Rank Supervised Joint Binary Embedding (Deep r-RSJBE) to perform multivariate time series retrieval. Given a raw multivariate time series segment, we employ Long Short-Term Memory (LSTM) units to encode the temporal dynamics and utilize Convolutional Neural Networks (CNNs) to encode the correlations (interactions) between different pairs of time series (sensors). Subsequently, a joint binary embedding is pursued to incorporate both the temporal dynamics and the correlations. Finally, we develop a novel r-th root ranking loss to optimize the precision at the top of a Hamming distance ranking list. Thoroughly empirical studies based upon three publicly available time series datasets demonstrate the effectiveness and the efficiency of Deep r-RSJBE.
[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2 (2013)

Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Despite progress in developing chemotherapeutics for the treatment of NSCLC, primary and secondary resistance limits therapeutic success. NSCLC cells exhibit multiple mutations in the epidermal growth factor receptor (EGFR), which cause aberrant activation of diverse cell signaling pathways. Therefore, suppression of the inappropriate amplification of EGFR downstream signaling cascades is considered to be a rational therapeutic and preventive strategy for the management of NSCLC. Our initial molecular target-oriented virtual screening revealed that the ginger components, including [6]-shogaol, [6]-paradol and [6]-gingerol, seem to be potential candidates for the prevention and treatment of NSCLC. Among the compounds, [6]-shogaol showed the greatest inhibitory effects on the NSCLC cell proliferation and anchorage-independent growth. [6]-Shogaol induced cell cycle arrest (G1 or G2/M) and apoptosis. Furthermore, [6]-shogaol inhibited Akt kinase activity, a downstream mediator of EGFR signaling, by binding with an allosteric site of Akt. In NCI-H1650 lung cancer cells, [6]-shogaol reduced the constitutive phosphorylation of signal transducer and activator of transcription-3 (STAT3) and decreased the expression of cyclin D1/3, which are target proteins in the Akt signaling pathway. The induction of apoptosis in NCI-H1650 cells by [6]-shogaol corresponded with the cleavage of caspase-3 and caspase-7. Moreover, intraperitoneal administration of [6]-shogaol inhibited the growth of NCI-H1650 cells as tumor xenografts in nude mice. [6]-Shogaol suppressed the expression of Ki-67, cyclin D1 and phosphorylated Akt and STAT3 and increased terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling-positivity in xenograft tumors. The current study clearly indicates that [6]-shogaol can be exploited for the prevention and/or treatment of NSCLC.
Methods for Labeling Quantum Dots to Biomolecules (2004)

Semiconductor quantum dots (QDs) are thought to be the most promising fluorescent probe for biological and biomedical applications because of their unique size-dependent optical and electronic properties. QD bioconjugates provide important advantages over conventional organic dyes. This review compares the optical properties of nanoparticles and dyes and describes the surface modification of the QDs and the methods for biomolecules conjugating to QDs. In addition, the effect of QDs on normal physiology in real biological applications is discussed.
Exposure of platelet fibrinogen receptors by ADP and epinephrine. (1979)

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Self-routing photonic switching with optically processed control (1990)

As transmission rates in fiber-optic networks increase, routing optical signals using electronic processing will become increasingly difficult. This limitation can be overcome by performing the required processing optically. Self-routing of optical signals through a switching node using optically processed control is demonstrated. Packet headers are encoded with packet destination addresses using either optical code-division or time-division encoding schemes. An optical routing controller reads the destination addresses and appropriately sets the photonic switch using an optical look-up table. The results of several experiments demonstrating optical control of a photonic switch are described.
Unraveled mechanism in silk engineering: Fast reeling induced silk toughening (2009)

We theoretically and experimentally study the mechanical response of silkworm and spider silks against stretching and the relationship with the underlying structural factors. It is found that the typical stress-strain profiles are predicted in good agreement with experimental measurements by implementing the “β-sheet splitting” mechanism we discovered and verified, primarily varying the secondary structure of protein macromolecules. The functions of experimentally observed structural factors responding to the external stress have been clearly addressed, and optimization of the microscopic structures to enhance the mechanical strength will be pointed out, beneficial to their biomedical and textile applications.
Inhibition of the Interaction between HIV-1 Integrase and its Cofactor LEDGF/p75: A Promising Approach in Anti-Retroviral Therapy (2011)

Although 25 compounds are currently licensed as anti-HIV drugs, the development of multidrug-resistant viruses, as well as their severe side effects, compromise their efficacy and limit treatment options. The search for new targets in order to cure AIDS has revealed that the inhibition of some protein-protein interactions in the HIV life cycle may provide an important new approach to fight this disease. The interaction between HIV-1 integrase (IN) and Lens Epithelium-Derived Growth Factor (LEDGF/p75) has increasingly gained attention as a valuable target for a novel anti-retroviral strategy. This article reviews the discovery and development of molecules capable of interrupting the LEDGF/p75-IN interaction reported to date.
Artificial DNA (2002)

Combining elements of biochemistry, molecular biology, and immunology, artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis, hybridization, amplification, protein engineering, anti-sense technology, DNA vaccines, protein vaccines, recombinant antibodies, screening fo
Temperature and SAR calculations for a human head within volume and surface coils at 64 and 300 MHz (2004)

Attempts to ensure RF safety in MRI often rely on assumptions about local temperature from local SAR levels. The relationship between local SAR and local temperature is not, however, straightforward. In cases where high SAR levels are required due to pulse sequence demands, calculations of temperature may be preferable to calculations of SAR because of the more direct relationship between temperature and safety.
Antiretroviral Activity of Semisynthetic Derivatives of Glycopeptide Antibiotics (2003)

A variety of semisynthetic derivatives of natural antibacterial glycopeptide antibiotics such as vancomycin, eremomycin, ristocetin A, teicoplanin A(2)-2, DA-40926, their aglycons, and also the products of their partial degradation with a destroyed or modified peptide core show marked anti-retroviral activity in cell culture. In particular, aglycon antibiotic derivatives containing various substituents of a preferably hydrophobic nature displayed activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and Moloney murine sarcoma virus at a 50% inhibitory concentration in the lower micromolar (1-5 microM) concentration range while not being cytostatic against human lymphocytic cells at 250 microM or higher. The mode of anti-HIV action of the antibiotic aglycon derivatives could be ascribed to inhibition of the viral entry process.
DNA Probes Using Fluorescence Resonance Energy Transfer (FRET): Designs and Applications (2001)

Fluorescence resonance energy transfer (FRET) is widely used in biomedical research as a reporter method. Oligonucleotides with a DNA backbone and one or several chromophore tags have found multiple applications as FRET probes. They are especially advantageous for the real-time monitoring of biochemical reactions and in vivo studies. This paper reviews the design and applications of various DNA-based probes that use FRET The approaches used in the design of new DNA FRET probes are discussed.
Treatment of IgM antibody associated polyneuropathies using rituximab (2003)

In patients with IgM autoantibody associated peripheral neuropathies, rituximab treatment is followed by reduced serum concentrations of IgM, but not IgG, antibodies, and by improvement in strength. Additional studies, with placebo controls and blinded outcome measures, are warranted to further test the efficacy of rituximab treatment of IgM associated polyneuropathies.