gebhart/patrepeval huggingface dataset:
Heparin and cilazapril together inhibit injury-induced intimal hyperplasia. (1991)

Both heparin and the angiotensin converting enzyme inhibitor cilazapril inhibit intimal thickening in rat carotid arteries injured by the passage of a balloon catheter. The purpose of this study was to determine if combinations of the two drugs were more effective than either drug alone and whether the effect could be accounted for by inhibition of smooth muscle cell proliferation. Heparin (0.1-0.3 mg/kg/hr) administered by continuous intravenous infusion with or without cilazapril (0-25 mg/kg/day p.o.) produced a dose-dependent inhibition of smooth muscle accumulation at 14 days after rat carotid ballooning. At the lower doses, the inhibitory effects of heparin and cilazapril were additive when the drugs were used together. This overall effect on growth was reflected in decreased smooth muscle cell proliferation at 2 and 7 days. A 7-day course of heparin combined with cilazapril, a regimen that might be applicable in the clinical setting, produced an 80% inhibition of intimal thickening at 28 days. These results provide evidence that heparin and cilazapril together might prove to be more effective than either drug alone in the control of intimal hyperplasia after arterial injury.
Synthesis of Monodisperse Spherical Nanocrystals (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Racemic cis-5-Hydroxy-3-phthalimidoglutarimide. A Metabolite of Thalidomide Isolated from Human Plasma (2005)

[reaction: see text] A synthesis of the glutarimide-derived metabolite of thalidomide, 5'-hydroxythalidomide (2), is described. The synthesis employed the lactone derivative of N-benzyloxycarbonyl (CBZ)-protected 4-hydroxyglutamic acid 12, which is prepared by a de novo route from diethyl acetamidomalonate. The reaction of 12 with 4-methoxybenzylamine gave the corresponding isoglutamine, which then provided the key CBZ-protected N-PMB-glutarimide 14 after dehydration. Deprotection of both the CBZ and PMB groups followed by phthalimidation and deacetylation of the 3-amino-5-acetoxyglutarimide 16 afforded 2.
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes (2009)

Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities-some defined principally by genetic features-that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes.
Infection of a child in Hong Kong by an influenza A H3N2 virus closely related to viruses circulating in European pigs (2001)

Influenza virus A/Hong Kong/1774/99, isolated from a young child with mild influenza, was shown to be similar in its antigenic and genetic characteristics to H3N2 viruses circulating in pigs in Europe during the 1990s and in particular to be closely related to viruses isolated from two children in the Netherlands in 1993. Similar viruses had previously not been identified outside Europe. Although there is little evidence as to how the child contracted the infection, it appears likely that pigs in southern China were the source of infection. Characteristics shared with the European swine viruses include resistance to the anti-influenza drugs amantadine and rimantadine. Thus not only does this incident once again highlight the potential of pigs as a source of novel human influenza viruses, but also indicates the potential for emergence of amantadine-resistant human viruses.
Object structure in the Emerald system (1986)

Emerald is an object-based language for the construction of distributed applications. The principal features of Emerald include a uniform object model appropriate for programming both private local objects and shared remote objects, and a type system that permits multiple user-defined and compiler-defined implementations. Emerald objects are fully mobile and can move from node to node within the network, even during an invocation. This paper discusses the structure, programming, and implementation of Emerald objects, and Emerald's use of abstract types.
Miniature all-silica fiber optic pressure and acoustic sensors (2005)

We present a miniature diaphragm-based Fabry-Perot (F-P) interferometric fiber optic sensor fabricated by novel techniques for pressure or acoustic wave measurement that is only approximately 0.32 mm in diameter. By choosing different diaphragm thicknesses and effective diameters, we obtain a sensor measurement range from 5 to 10,000 psi (1 psi = 51.72 Torr) and a frequency response up to 2 MHz. In addition, the sensor's F-P cavity can be set from micrometers to millimeters with a precision of several nanometers. With the all-silica structure, the sensor is reliable, biocompatible, and immune to electromagnetic interference and has high-temperature sensing capability.
A Novel Tuberculosis DNA Vaccine in an HIV-1 p24 Protein Backbone Confers Protection against Mycobacterium tuberculosis and Simultaneously Elicits Robust Humoral and Cellular Responses to HIV-1 (2012)

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major infectious disease worldwide. Moreover, latent M. tuberculosis infection is more likely to progress to active TB and eventually leads to death when HIV infection is involved. Thus, it is urgent to develop a novel TB vaccine with immunogenicity to both M. tuberculosis and HIV. In this study, four uncharacterized T cell epitopes from MPT64, Ag85A, Ag85B, and TB10.4 antigens of M. tuberculosis were predicted, and HIV-1-derived p24, an immunodominant protein that can induce protective responses to HIV-1, was used as an immunogenic backbone. M. tuberculosis epitopes were incorporated separately into the gene backbone of p24, forming a pP24-Mtb DNA vaccine. We demonstrated that pP24-Mtb immunization induced a strong M. tuberculosis-specific cellular response as evidenced by T cell proliferation, cytotoxicity, and elevated frequency of gamma interferon (IFN-γ)-secreting T cells. Interestingly, a p24-specific cellular response and high levels of p24-specific IgG were also induced by pP24-Mtb immunization. When the protective effect was assessed after mycobacterial challenge, pP24-Mtb vaccination significantly reduced tissue bacterial loads and profoundly attenuated the mycobacterial infection-related lung inflammation and injury. Our findings demonstrated that the pP24-Mtb tuberculosis vaccine confers effective protection against mycobacterial challenge with simultaneously elicited robust immune responses to HIV-1, which may provide clues for developing novel vaccines to prevent dual infections.
A new GPU-based approach to the Shortest Path problem (2013)

The Single-Source Shortest Path (SSSP) problem arises in many different fields. In this paper we present a GPU-based version of the Crauser et al. SSSP algorithm. Our work significantly speeds up the computation of the SSSP, not only with respect to the CPU-based version, but also to other state-of-the-art GPU implementation based on Dijkstra, due to Martín et al. Both GPU implementations have been evaluated using the last Nvidia architecture (Kepler). Our experimental results show that the new GPU-Crauser algorithm leads to speed-ups from 13× to 220× with respect to the CPU version and a performance gain of up to 17% with respect the GPU-Martên algorithm.
CHLORIN AND PORPHYRIN DERIVATIVES AS POTENTIAL PHOTOSENSITIZERS IN PHOTODYNAMIC THERAPY (1991)

In order to find a photosensitizer with better optical properties and pharmacokinetics than Photofrin II, a series of new photosensitizers related to methyl pheophorbide-a and chlorin-e6 were synthesized. These compounds absorb at substantially longer wavelengths (lambda max 660 nm) than does Photofrin II (630 nm) and show promise for use in photodynamic therapy. Among the porphyrins, we observed that long carbon chain ether derivatives are better photosensitizers than their ester analogs. These sensitizers were tested for in vivo photosensitizing activity vis-a-vis Photofrin II, using the standard screening system of DBA/2 mice bearing transplanted SMT/F tumors. Most of these photosensitizers were found to have better tumoricidal photosensitizing activity than Photofrin II and demonstrated more rapid attenuation of normal tissue photosensitivity with time after administration vis-a-vis Photofrin II.
Critical Update and Emerging Trends in Epidermal Growth Factor Receptor Targeting in Cancer (2005)

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB receptor family that is abnormally activated in many epithelial tumors. The aberrant activation of the EGFR leads to enhanced proliferation and other tumor-promoting activities, which provide a strong rationale to target this receptor family. There are two classes of anti-EGFR agents: monoclonal antibodies (MAbs) directed at the extracellular domain of the receptor and small molecule, adenosine triphosphate-competitive inhibitors of the receptor's tyrosine kinase. Anti-EGFR MAbs have shown antitumor activity in advanced colorectal carcinoma, squamous cell carcinomas of the head and neck, non-small-cell lung cancer (NSCLC) and renal cell carcinomas. The tyrosine kinase inhibitors (TKIs) have a partially different activity profile. They are active against NSCLC, and a specific EGFR inhibitor has shown improvement in survival. Recently, mutations and amplifications of the EGFR gene have been identified in NSCLC and predict for enhanced sensitivity to anti-EGFR TKIs. In addition to specific anti-EGFR TKIs, there are broader acting inhibitors such as dual EGFR HER-2 inhibitors and combined anti-pan-ErbB and antivascular endothelial growth factor receptor inhibitors. Current research efforts are directed at selecting the optimal dose and schedule and identifying predictive factors of response and resistance beyond EGFR gene mutations and/or amplifications. Finally, there is a need for improved strategies to integrate anti-EGFR agents with conventional therapies and to explore combinations with other molecular targeted approaches including other antireceptor therapies, receptor-downstream signaling transduction inhibitors, and targeted approaches interfering with other essential drivers of cancer, such as angiogenesis.
The effects of thalidomide and two analogues on the regenerating forelimb of the newt (1977)

Oral administration (3 mg/day) of thalidomide during the dedifferentiation and early limb-bud stages of newt forelimb regeneration produced a variety of specific limb deformities. Proximal and preaxial skeletal elements were the most severely malformed, e.g. preaxial hemimelia, severe proximal deformities, and preaxial polydactyly. Likewise, oral, daily doses (3 mg) of the teratogenic analogue, EM12, on days 7 and 8 following bilateral amputation caused the same incidence and type of forelimb abnormalities as did thalidomide. Conversely, the non-teratogenic analogue, EM87, when orally administered (3 mg/day) on days 7 and 8 post-amputation resulted in a low rate of limb deformities, similar in type to those seen in control regenerates. The type of limb deformities observed in the regenerating newt forelimb following thalidomide treatment nearly mimic those seen in the human and monkey syndromes. Therefore, the newt represents a possible model for investigating some of the problems associated with thalidomide teratogenesis.
Photophysics and photochemistry of oxygen sensors based on luminescent transition-metal complexes (1991)

A detailed study of the photophysics and photochemistry of&#13;\npolymer-immobilized luminescent transition-metal complex&#13;\noxygen sensors is presented. Emphasis is on understanding&#13;\nthe underlying origin of the nonlinear Stern-Volmer quenching response. Microheterogeneity is important in both photophysical and photochemical behavior, and the nonlinear&#13;\nquenching responses in RTV 118 silicone rubber can be adequately described by a two-site model, although detailed&#13;\nlifetime measurements suggest a more complex Underlying&#13;\nsystem. Counterion studies with quenching counterions are&#13;\nshown to be useful probes of the structure of the complex in&#13;\nthe polymer. While oxygen enhances photochemical instability, singlet oxygen is not directly implicated in sensor decomposition. In the photochemistry there is at least one reactive and one much less reactive site, although the photochemistry and quenching measurements probably sample different populations of sites. The existence of reactive sites suggests that stability can be enhanced by a preliminary photolysis to eliminate the more reactive sites.
Quantitative imaging of I‐124 using positron emission tomography with applications to radioimmunodiagnosis and radioimmunotherapy (1991)

Positron emission tomography (PET) is potentially useful for the quantitative imaging of radiolabeled antibodies, leading in turn to improved dosimetry in radioimmunotherapy. Iodine-124 is a positron-emitting nuclide with appropriate chemical properties and half-life (4.2 days) for such studies since the radiolabeling of antibodies with iodine is well understood and the half-life permits measurements over several days. Unfortunately, I-124 has a complex decay scheme with many high-energy gamma rays and a positron abundance of only 25%. It has therefore been largely ignored as a PET-imaging nuclide. However, measurements made with phantoms and animals under realistic conditions using a BGO-based PET scanner have shown that satisfactory imaging and quantitation can be achieved. Investigations of spatial resolution, the linearity of regional observed count rate versus activity in the presence of other activity, and the visualization and quantitation of activity in spheres with different surrounding background activities were carried out with phantoms up to 22 cm in diameter. Compared with F-18, spatial resolution was only slightly degraded (13.5 mm FWHM vs 12 mm FWHM) while linearity was the same over a 10:1 activity range (0.015 to 0.15 MBq/ml for I-124). The visualization and quantitation of spheres was also slightly degraded when using similar imaging times. Increasing the imaging time for I-124 reduced the difference. To verify that the technique would work in vivo, measurements were made of human neuroblastoma tumors in rats which had been injected with I-124 labeled 3F8 antibody. Although the number of samples was small, good agreement was achieved between image-based measurements and direct measurements of excised 4-g tumors. Thus quantitative imaging of I-124 labeled antibodies appears to be possible under realistic conditions.
The Galileo and Pioneer Venus ultraviolet spectrometer experiments - Solar Lyman-alpha latitude variation at solar maximum from interplanetary Lyman-alpha observations (1992)

Solar Ly-alpha latitude variation at solar maximum is examined on the basis of interplanetary Ly-alpha observations made during the Galileo and Pioneer Venus UV spectrometer experiments. A comparison is made of the latitude variation of the interplanetary (IP) Ly-alpha signal in 1986 at solar minimum from Pioneer Venus and in 1990 at solar maximum from Galileo. The Galileo EUV spectrometer shows that a large enhancement of the IP Ly-alpha emission occurred over the intervening four years near the solar equator. An IP Ly-alpha model is developed which considers the latitude variation of the solar Ly-alpha flux. The model fit to the data shows a 25-percent decrease of the full disk solar Ly-alpha flux from solar equator to solar pole in 1990. A detailed study of the Galileo IP Ly-alpha observations on day-of-year 190, 193, 197, and 200 in 1990 reveals that large variations occur in response to the 27-d solar variation. Analysis of these data shows that a maximum variation of 20 percent can be expected in the IP Ly-alpha upwind intensity over this 27-d period.
Accuracy analysis of an image-guided system for vertebroplasty spinal therapy based on electromagnetic tracking of instruments (2008)

Vertebroplasty is a minimally invasive procedure in which bone cement is pumped into a fractured vertebral body that has been weakened by osteoporosis, long-term steroid use, or cancer. In this therapy, a trocar (large bore hollow needle) is inserted through the pedicle of the vertebral body which is a narrow passage and requires great skill on the part of the physician to avoid going outside of the pathway. In clinical practice, this procedure is typically done using 2D X-ray fluoroscopy. To investigate the feasibility of providing 3D image guidance, we developed an image-guided system based on electromagnetic tracking and our open source software platform the Image-Guided Surgery Toolkit (IGSTK). The system includes path planning, interactive 3D navigation, and dynamic referencing. This paper will describe the system and our initial evaluation.
Effects of Androgens, Estrogens and Corticoids on Strontium Kinetics in Man1 (1966)

The effects of estrogens, androgens and corticoids on kinetics of stable strontium metabolism were evaluated. The rapidly miscible pool volume, bone deposition rate and urinary excretion rate were determined before and after treatment of 67 subjects with androgens and estrogens, 44 subjects with corticoids and 34 subjects with placebos. Androgens and estrogens decreased urinary excretion rates and estrogens tended to decrease bone deposition. They thus appear to be anticatabolic for bone instead of anabolic, as previously thought. Estrogens may also be anti-anabolic. Corticoids did not decrease bone deposition rates, but did uniformly increase urinary excretion rates. They thus do not appear to be anti-anabolic for bone, as previously thought. Correction of bone deposition rates for fecal excretion rates did not affect the results. These studies did not reveal whether the changes in urinary excretion rates induced by both gonadal and glucocorticoid steroids were attributable to effects on the kidney, on the bone, or both.
Solvent selection via miscibility number (1972)

In formulating a mixed solvent or selecting a reaction medium, chemists have to deal with the phenomena of liquid miscibility. The author has collected and correlated a great amount of miscibility data; a typical portion of the master chart constructed from these data is illustrated. The liquids are arranged in an order that results in a stair-step arrangement of the boundaries between miscibility (m) and borderline-immiscibility (b). The hypothetical property that determines this order may be called lipophilicity, or affinity for oil-like substances. Finally the range between the extremes of low and high lipophilicity was partitioned into 31 classes, each composed of liquids showing the same miscibility relationships with other liquids. Assuming that the intervals between these miscibility classes are made as uniform as possible according to some logical criterion, the position of a class in the series should have quantitative significance as a measure of lipophilicity. This serial number is called the miscibility number, or M-number for short. A chart illustrating the relationship between the standard solvents (and the miscibility classes) is presented. An alphabetic list of organic liquids that have been given M-numbers also is shown. When applied to other pairs of liquids selected from the tabulr data,more » it leads to a high percentage of valid predictions.« less
Selection of features for the classification of wood board defects (1999)

We compare three methods for selecting features that have recently been applied to the classification of defects on wood boards. A first method is based on statistical measures to determine how well features differentiate between classes. A second method consists of leaving out each of the features in turn and performing classification on the remaining features. A third method is based on genetic algorithms. The performances of the three methods are measured on a database containing color images of 900 pine wood defects classified into 9 categories. The best overall performance obtained was 93% of correct classifications on a test set, with only 20 out of 72 original features.
A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins (1991)

The major immediate-early (IE) promoter of human cytomegalovirus directs the expression of several differentially spliced and polyadenylated mRNAs that encode isoformic proteins with apparent molecular masses of 55, 72, and 86 kDa. All of these proteins are potent transcriptional regulatory proteins. We are interested in the collateral interactions between human cytomegalovirus and human immunodeficiency virus (HIV) in the context of dual infection of a cell. The roles of the specific IE protein isoforms and their respective response elements involved in trans activation of the HIV long terminal repeat (LTR) are not known. Here we present evidence that major IE proteins IE86, IE72, and IE55 are capable of trans-activating the HIV LTR in a T-cell line, HUT-78. The IE55 isoform noncooperatively stimulates the HIV LTR in the presence of either isoform IE72 or IE86. Interactions between isoforms IE72 and IE86, however, result in strong synergistic activation of the LTR. Our results suggest that a specific 155-amino-acid protein domain that is unique for the IE86 protein participates in this synergic interaction. Point mutational analysis of the LTR identified a distinct cis-acting target site, located between nucleotide positions -174 and -163, that mediates exclusively synergistic trans activation by the IE72 and IE86 proteins. Finally, this study underscores the role of a cellular intermediate(s) for communicating the synergic interactions between two IE trans activators.