gebhart/patrepeval huggingface dataset:
Band-edge discontinuities of strained-layer InxGa1−xAs/GaAs heterojunctions and quantum wells (1989)

The conduction-band discontinuity (ΔEc ) and the band-gap offset (ΔEgh) of InxGa1−xAs/GaAs multiple quantum wells grown on GaAs substrates by molecular beam epitaxy are investigated for 0&amp;lt;x&amp;lt;0.3. The band gap of strained InxGa1−xAs , determined from the excitonic transition of room-temperature transmission spectra, is found to be linearly dependent on x and is in good agreement with the calculated values. The band-gap offset is found to be ΔEgh =1.15x eV. The conduction-band offset, compiled from published data, is ΔEc =0.75x eV, and thus (ΔEc /ΔEgh)=0.65 independent of x.
110 kv Cau Go transmission line and substation EMP (2004)

This is an environmental assessment for Vietnam's Transmission and Distribution Development Project, in which the Playcu-Phulam transmission line integrates small and medium power generation, such as linking hydropower in the western highlands with the rest of the country. Transmission lines will help create a reliable, economical power supply in the South. Construction activities such as cutting trees, clearing routes, digging foundation holes, transporting material, and tensioning conductors can cause soil erosion. Mitigating options include soil replacing, and tree and grass planting. To offset hunting and poaching, fences will be erected and foresty controllers will increase their supervision and inspections. To prevent fire or explosion caused by hazardous spills, construction crews will be supplied protection equipment. To reduce disease risk in construction camps, medical and hygienic measures for handling water and foodstuffs will be firmly adhered to. During the operational phase, the threat of soil erosion around the towers can be alleviated by building a foundation embankment or contouring on sloping land. Trees posing a safety hazard because they are too close to transmission lines will be cut down periodically. A resettlement action plan recommends solutions for compensation, population relocation, and household restoration.
Modeling of capillary forces and binding sites for fluidic self-assembly (2002)

Massively parallel self-assembly is emerging as an efficient, low-cost alternative to conventional pick-and-place assembly of microfabricated components. The fluidic self-assembly technique we have developed exploits hydrophobic-hydrophilic surface patterning and capillary forces of an adhesive liquid between binding sites to drive the assembly process. To achieve high alignment yield, the desired assembly configuration must be a (global) energy minimum, while other (local) energy minima corresponding to undesired configurations should be avoided. Thus, the design of an effective fluidic self-assembly system using this technique requires an understanding of the interfacial phenomena involved in capillary forces; improvement of its performance involves the global optimization of design parameters such as binding site shapes and surface chemistry. This paper presents a model and computational tools for the efficient analysis and simulation of fluidic self-assembly. The strong, close range attractive forces that govern our fluidic self-assembly technique are approximated by a purely geometric model, which allows the application of efficient algorithms to predict system behavior. Various binding site designs are analyzed, and the results are compared with experimental observations. For a given binding site design, the model predicts the outcome of the self assembly process by determining minimum energy configurations and detecting unwanted local minima, thus estimating expected yield. These results can be employed toward the design of more efficient self-assembly systems.
Three-Dimensional Solution Structure of Lactoferricin B, an Antimicrobial Peptide Derived from Bovine Lactoferrin (1998)

The solution structure of bovine lactoferricin (LfcinB) has been determined using 2D 1H NMR spectroscopy. LfcinB is a 25-residue antimicrobial peptide released by pepsin cleavage of lactoferrin, an 80 kDa iron-binding glycoprotein with many immunologically important functions. The NMR structure of LfcinB reveals a somewhat distorted antiparallel beta-sheet. This contrasts with the X-ray structure of bovine lactoferrin, in which residues 1-13 (of LfcinB) form an alpha-helix. Hence, this region of lactoferricin B appears able to adopt a helical or sheetlike conformation, similar to what has been proposed for the amyloidogenic prion proteins and Alzheimer's beta-peptides. LfcinB has an extended hydrophobic surface comprised of residues Phe1, Cys3, Trp6, Trp8, Pro16, Ile18, and Cys20. The side chains of these residues are well-defined in the NMR structure. Many hydrophilic and positively charged residues surround the hydrophobic surface, giving LfcinB an amphipathic character. LfcinB bears numerous similarities to a vast number of cationic peptides which exert their antimicrobial activities through membrane disruption. The structures of many of these peptides have been well characterized, and models of their membrane-permeabilizing mechanisms have been proposed. The NMR solution structure of LfcinB may be more relevant to membrane interaction than that suggested by the X-ray structure of intact lactoferrin. Based on the solution structure, it is now possible to propose potential mechanisms for the antimicrobial action of LfcinB.
[Preparation and identification of monoclonal antibody against UGP2]. (2007)

The study was aimed to generate monoclonal antibodies (mAbs) against homo sapiens UDP-glucose pyrophosphorylase 2 (UGP2). Normal human liver tissues homogenized, and cytosolic proteins isolated by centrifugation were used to immunize BALB/c mice to generate mAbs by hybridoma technique. The mAbs were identified by ELISA, Western blot, and immunohistochemistry assay. The antibody specificity was confirmed by Uni-ZAP expression library screening. The results indicated that one hybridoma BAD062 secreting specific mAb against UGP2 was established. The Ig subclass of this mAb was IgG(2b) (kappa), and it could be used in ELISA, Western blot, immunohistochemistry assay. The antigen recognized by BAD062 mAb was localized in the hepatocyte cytoplasm, with molecular weight of 56 kD in the cytosolic proteins of human liver tissue. The BAD062 mAb was further confirmed by immunoscreening of Uni-ZAP XR liver cDNA expression library. It is concluded that a hybridoma cell line stably secretes specific mAb against UGP2. This mAb reacted with UGP2 in ELISA, Western blot, immunohistochemistry assay, and would be very useful for the UGP2 studies.
A New QPSK Lock Detector for Digital Receiver (1997)

A new lock detection algorithm for digital QPSK receiver is proposed. Analysis of the detector's output characteristics is given and is verified by using computer simulation. performance degradation due to carrier jitter is also considered. Analytic and simulated results show that the proposed algorithm is very useful as a lock detector in the digital receiver because it has a good detection performance and simple structure.
Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 × 1012) sequences (1994)

A decapeptide positional-scanning synthetic-peptide combinatorial library (PS-SPCL) made up of four trillion (4 x 10(12) decapeptides was synthesized; its use is illustrated here for the study of a peptide-antibody interaction. This library was prepared by a chemical-mixture approach using a specific ratio of amino acids empirically determined to give approximately equimolar incorporation of each amino acid during each coupling step. Despite the immense number of decapeptides making up each peptide mixture [approx. 200 billion (2 x 10(11)], specific sequences having nanomolar affinities for a peptide-antibody interaction could be readily identified. Upon screening this decapeptide PS-SPCL in this well characterized system, the known six-residue antigenic-determinant sequence was found, with the most specific residues appearing to 'walk through' the ten positions of the peptide library. More importantly, it appears that antibody recognition in this system is stronger when the antigenic determinant is located at the C-terminus of the decapeptide library. Individual decapeptides corresponding to sequences derived from the most active peptide mixtures at each position were synthesized to confirm the results of the screening; 15 peptides were found to have IC50 values between 0.6 and 9.5 nM, four of which were found to be 5-10 times more active than the known six- and 13-residue control peptides. These results further illustrate the power of the positional-scanning peptide library concept, and extend its practical range to a decamer library composed of four trillion (4 x 10(12) decapeptides.
Interleukin-12 expression in human lymphomas and nonneoplastic lymphoid disorders (1995)

Interleukin-12 (IL-12), a cytokine with in vitro and in vivo immunomodulatory effects, is produced by lymphocytes and stimulated monocytes. Little is known about the production and possible role of IL-12 in human lymphoproliferative disorders. We examined IL-12 expression by immunohistochemistry using antibodies recognizing the p40, p35 subunits, and the p70 heterodimeric IL-12 protein, and by Northern blot in lymph nodes from patients with Hodgkin's disease (HD), non-Hodgkin's lymphomas (NHL), and nonneoplastic lymphoid lesions. In the majority of the HD cases (28 of 34), IL-12 immunoreaction was found in small lymphoid cells cultured around Hodgkin and Reed-Sternberg (H&RS) cells. No IL-12 signal was seen in H&RS cells. Transcripts for IL-12 were found by Northern and dot blot analysis in 13 of 19 (IL-12 p40) and 11 of 19 (IL-12 p35) cases. The HD cases were further examined for the presence of Epstein-Barr virus (EBV) latent membrane protein (LMP-1). All cases with EBV-LMP-1 positivity (22 of 34 cases) also expressed IL-12. No IL-12 immunoreaction was found in neoplastic cells of 33 cases of various NHLs, which were all LMP-1 negative and showed no EBV-genome sequence, as assessed by polymerase chain reaction (PCR). In 24 nonneoplastic lymphoid lesions, few dispersed IL-12 positive cells were seen in the parafollicular area and in the sinus of the lymph node. The marked presence of IL-12 in the majority of HD cases indicates that IL-12 might play a role in the pathobiology of HD, suggesting that this cytokine is involved in EBV-positive HD.
Full-Automatic Dj Mixing System With Optimal Tempo Adjustment Based On Measurement Function Of User Discomfort. (2009)

[TODO] Add abstract here.
104. Studies on specific chemical fission of peptide links. Part III. Fission of peptides containing one glutamic acid residue (1961)

A. R. Battersby and J. J. Reynolds, J. Chem. Soc., 1961, 524 DOI: 10.1039/JR9610000524
Production of Activated Carbon from Biochar Using Chemical and Physical Activation: Mechanism and Modeling (2007)

Biochar, a solid product of fast pyrolysis of biomass, was converted to activated carbon by physical (steam) and chemical (potassium hydroxide) activation. The effects of operating conditions on the BET surface area and the reaction yield of physically and chemically activated carbons were investigated. Two models for BET surface area and reaction yield of each activated carbon were developed. Using these models, the optimum operating conditions for production of activated carbons with large surface area and high yield were determined. The BET surface area and yield of products predicted by models and from experiments at optimum operating conditions showed good agreement. The effects of activating agent on the chemical structure of biochar, duringchemical activation, were investigated by thermogravimetric method and infrared spectroscopy.
Combined MTOR and autophagy inhibition (2014)

The combination of temsirolimus (TEM), an MTOR inhibitor, and hydroxychloroquine (HCQ), an autophagy inhibitor, augments cell death in preclinical models. This phase 1 dose-escalation study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with TEM in cancer patients. In the dose escalation portion, 27 patients with advanced solid malignancies were enrolled, followed by a cohort expansion at the top dose level in 12 patients with metastatic melanoma. The combination of HCQ and TEM was well tolerated, and grade 3 or 4 toxicity was limited to anorexia (7%), fatigue (7%), and nausea (7%). An MTD was not reached for HCQ, and the recommended phase II dose was HCQ 600 mg twice daily in combination with TEM 25 mg weekly. Other common grade 1 or 2 toxicities included fatigue, anorexia, nausea, stomatitis, rash, and weight loss. No responses were observed; however, 14/21 (67%) patients in the dose escalation and 14/19 (74%) patients with melanoma achieved stable disease. The median progression-free survival in 13 melanoma patients treated with HCQ 1200mg/d in combination with TEM was 3.5 mo. Novel 18-fluorodeoxyglucose positron emission tomography (FDG-PET) measurements predicted clinical outcome and provided further evidence that the addition of HCQ to TEM produced metabolic stress on tumors in patients that experienced clinical benefit. Pharmacodynamic evidence of autophagy inhibition was evident in serial PBMC and tumor biopsies only in patients treated with 1200 mg daily HCQ. This study indicates that TEM and HCQ is safe and tolerable, modulates autophagy in patients, and has significant antitumor activity. Further studies combining MTOR and autophagy inhibitors in cancer patients are warranted.
Understanding and Engineering Social Dynamics (2016)

All activities on social media evolve with time. Consequently, being able to understand and engineer social dynamics, the way how various properties of social media evolve, is a central question for social networks research. While recent work has studied social dynamics from various angles, two important properties of social dynamics are yet to be addressed, i.e., heterogeneous features and signatures at multiple time scales. However, considering heterogeneous features is necessary to build a general tool with wide applicability, whereas considering multiple time scales is indispensable to study how social dynamics in different time scales interact with one another. In this thesis, we aim at addressing these two properties using computational algorithms with statistical groundings. In particular, we propose scalable and effective methods for three basic tasks: pattern mining, structure decomposition, and data driven dynamics engineering. For each task, the proposed methods are analyzed formally and verified empirically. The results reveal several interesting insights and demonstrate various practical applications, such as dynamics prediction, anomaly detection, and targeted intervention. Finally, the methods we propose in this thesis are general enough to handle multi-dimensional time series; we have explored this direction by considering other applications, such as human behavior recognition and macroeconomics.
Mammalian cell delivery via aerosol deposition (2004)

The objective of this study was to test the hypothesis that bovine dermal fibroblasts can survive aerosol delivery via an airbrush with mean cell survival rates greater than 50%. This technology has great implications for burn and other wound therapies, for delivery of genetically altered cells in gene therapies, and for tissue engineering with tissue scaffolds. Bovine dermal fibroblasts were suspended at a concentration of 200,000 cells/mL in Hank's Balanced Salt Solution, and delivered into six-well tissue culture plates using a Badger 100G airbrush. Cells were delivered through three nozzle diameters (312, 484, and 746 microm) at five different air pressures (41, 55, 69, 96, and 124 kPa). Nine repetitions were performed for each treatment group, and cell viability was measured using trypan blue exclusion assay. Mean cell viability ranged from 37 to 94%, and depended on the combination of nozzle diameter and delivery pressure (p < 0.0001). Linear regression analysis was used to develop a stochastic model of cell delivery viability as a function of nozzle diameter and delivery air pressure. This study demonstrates the feasibility of using an airbrush to deliver viable cells in an aerosol to a substrate.
Subunit association and side-chain reactivities of bovine erythrocyte superoxide dismutase in denaturing solvents (1979)

The copper- and zinc-containing superoxide dismutase of bovine erythrocytes retains its native molecular weight of 32 000 in 8.0 M urea for at least 72 h at 25 degrees C, as evidenced by sedimentation equilibrium analysis. Subsequent to prolonged exposure to urea, the dimeric enzyme could be dissociated by sodium dodecyl sulfate in the absence of reductants, indicating the absence of unnatural disulfide cross-links. The sulfhydryl group of cysteine-6 was unreactive toward 5,5'-dithiobis(2-nitrobenzoic acid) or bromoacetic acid in both neutral buffer and 8.0 M urea. The histidine residues of the enzyme were resistant to carboxymethylation in neutral buffer and 8.0 M urea. However, when the enzyme was exposed to bromoacetic acid in the presence of 6.0 M guanidinium chloride and 1 mM (ethylenedinitriol)tetraacetic acid (EDTA), both sulfhydryl and histidine alkylation were observed. Guanidinium chloride (6.0 M) increased the reactivity of the sulfhydryl group of cysteine-6 and allowed the oxidative formation of disulfide-bridged dimers. This was prevented by 1 mM EDTA. It follows that 8.0 M urea neither dissociates the native enzyme into subunits nor produces a conformation detectably different than that possessed under native conditions.
Efficacy Results of a Trial of a Herpes Simplex Vaccine (2012)

In a study population that was representative of the general population of HSV-1- and HSV-2-seronegative women, the investigational vaccine was effective in preventing HSV-1 genital disease and infection but not in preventing HSV-2 disease or infection. (Funded by the National Institute of Allergy and Infectious Diseases and GlaxoSmithKline; ClinicalTrials.gov number, NCT00057330.).
Collecting Internet Malware Based on Client-side Honeypot (2008)

With the improvement of software security, attacks based on RPC vulnerabilities declined, however, attacks based on client application software vulnerabilities have increased. Such client application software includes Web browsers, email client and office. The spread of malware using these software vulnerabilities has become a severe threat to todaypsilas Internet. In allusion to this kind of threat, this paper designed an Internet malware collecting system based on client-side honeypot. This system can not only collect malware but also detect malicious Web site. It uses a unique network crawler based on client-side attack techniques to collect source of URL, and it collects URL and attachments from emails, then it creates software processes to open URL or files, and uses a device-drive monitor to detect malicious behaviors. It gives an alarm and locates the malicious file, and sends the malware coming through the Internet to the collecting server. We introduce the design and implement of this system and give the results.
Distributed shared persistent memory (2017)

Next-generation non-volatile memories (NVMs) will provide byte addressability, persistence, high density, and DRAM-like performance. They have the potential to benefit many datacenter applications. However, most previous research on NVMs has focused on using them in a single machine environment. It is still unclear how to best utilize them in distributed, datacenter environments.
Texaphyrins: Tumor Localizing Redox Active Expanded Porphyrins (2011)

Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.
Peptide nucleic acid (PNA) (2006)

PNA (peptide nucleic acid) is a DNA mimic in which the natural deoxyribosephosphate diester backbone of the nucleic acid has been exchanged for a pseudo peptide (amide) backbone composed of 2-aminoethyl glucine unit having the nucleobase attached to the glycine nitrogen via an ‘acetyl’ linker [l–4] (Figure 1). This backbone structure is homomorphous to that of the natural nucleic acid as indicated by chemical bond distances as well as by computer model building. PNA was originally conceived as a reagent designed to bind sequence specifically to double stranded DNA via major groove triplex recognition [1]. Quite surprisingly, however, it was discovered that binding of homopyrimidin PNA to double stranded targets takes place via a strand displacement mechanism involving an extremely stable PNA2 –DNA triplex (Figure 2) [1,5,6]. Furthermore, PNA oligomers also recognize complemen-
Lysophospholipids in development: Miles apart and edging in (2004)

Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are endogenous bioactive lipids that participate in the regulation of mammalian cell proliferation, apoptosis, migration, and angiogenesis. These processes are each critical for successful embryogenesis, raising the possibility that lysophospholipid signaling may contribute to normal animal development. In fact, recent studies in developmental model systems have established that S1P and LPA are necessary for diverse developmental programs including those required for morphogenesis of vertebrate reproductive, cardiovascular and central and peripheral nervous systems (PNS), as well as the establishment of maternal-fetal circulation and the immune system. Genetic, morphological, and biochemical characterization of developmental model systems offer powerful approaches to elucidating the molecular mechanisms of lysophospholipid signaling and its contributions to animal development and postnatal physiology. In this review, the routes of S1P and LPA metabolism and our current understanding of lysophospholipid-mediated signal transduction in mammalian cells will be summarized. The evidence implicating lysophospholipid signaling in the development of specific vertebrate systems will then be reviewed, with an emphasis on signals mediated through G protein-coupled receptors of the Edg family. Lastly, recent insights derived from the study of simple metazoan models and implications regarding lysophospholipid signaling in organisms in which Edg receptors are not conserved will be explored.
Interdisciplinary Gerontology Education Online: A Developmental Process Model (2004)

Distance education online in gerontology in academic settings is designed to reflect content relevant to gerontology practices, academic standards, teaching strategies, and technology that embrace content delivery while enhancing learning. A balance with community services and needs for older adult populations, academic integrity, stakeholders, and resources, with an interdisciplinary and multidisciplinary student-centered approach are important. Considering these factors and based on a needs assessment, this article describes a process model used to create an interdisciplinary gerontology education program for online delivery at Florida Gulf Coast University (FGCU). The realities, pearls of wisdom, and lessons learned from creating and implementing the FGCU online interdisciplinary undergraduate gerontology education in the academic setting are also presented.