gebhart/patrepeval huggingface dataset:
Copper(II)/Tertiary Amine Synergy in Photoinduced Living Radical Polymerization: Accelerated Synthesis of ω-Functional and α,ω-Heterofunctional Poly(acrylates) (2013)

Photoinduced living radical polymerization of acrylates, in the absence of conventional photoinitiators or dye sensitizers, has been realized in "daylight'"and is enhanced upon irradiation with UV radiation (λ(max) ≈ 360 nm). In the presence of low concentrations of copper(II) bromide and an aliphatic tertiary amine ligand (Me6-Tren; Tren = tris(2-aminoethyl)amine), near-quantitative monomer conversion (>95%) is obtained within 80 min, yielding poly(acrylates) with dispersities as low as 1.05 and excellent end group fidelity (>99%). The versatility of the technique is demonstrated by polymerization of methyl acrylate to a range of chain lengths (DP(n) = 25-800) and a number of (meth)acrylate monomers, including macromonomer poly(ethylene glycol) methyl ether acrylate (PEGA480), tert-butyl acrylate, and methyl methacrylate, as well as styrene. Moreover, hydroxyl- and vic-diol-functional initiators are compatible with the polymerization conditions, forming α,ω-heterofunctional poly(acrylates) with unparalleled efficiency and control. The control retained during polymerization is confirmed by MALDI-ToF-MS and exemplified by in situ chain extension upon sequential monomer addition, furnishing higher molecular weight polymers with an observed reduction in dispersity (Đ = 1.03). Similarly, efficient one-pot diblock copolymerization by sequential addition of ethylene glycol methyl ether acrylate and PEGA480 to a poly(methyl acrylate) macroinitiator without prior workup or purification is also reported. Minimal polymerization in the absence of light confers temporal control and alludes to potential application at one of the frontiers of materials chemistry whereby precise spatiotemporal "on/off" control and resolution is desirable.
Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER) (2019)

The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degraders based on the proteolysis targeting chimeras (PROTAC) concept. Our efforts have resulted in the discovery of highly potent and effective PROTAC ER degraders, as exemplified by ERD-308 (32). ERD-308 achieves DC<sub>50</sub> (concentration causing 50% of protein degradation) values of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively, and induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines. Significantly, ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells. Further optimization of ERD-308 may lead to a new therapy for advanced ER+ breast cancer.
Shared Desktop: a collaborative tool for sharing 3-D applications among different Window systems (1997)

software application that supports the sharing of three-dimensional graphics and audio across the network. The Shared Desktop application enables the collaborative use of any application over local and long-distance networks, as well as interoperation among Windows- and UNIXbased computers. Its simple user interface employs screen capture and data compression techniques and a high-level protocol to transmit packets using TCP/IP over the Internet. An advanced product development effort undertaken by graphics engineers in the DIGITAL Workstations Group led to the creation of a new software application called Shared Desktop. One project goal was to enable collaboration among users of three-dimensional (3-D)
Screening for Major Depression in Epilepsy with Common Self‐report Depression Inventories (2005)

Common self-report depression measures can be used to screen for major depression in clinical settings. Use of these measures will assist in the clinical identification of patients with major depression so that treatment can be initiated.
Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice (2016)

Post-traumatic stress disorder (PTSD) has been declared 'a life sentence' based on evidence that the disorder leads to a host of physical health problems. Some of the strongest empirical research - in terms of methodology and findings - has shown that PTSD predicts higher risk of cardiometabolic diseases, specifically cardiovascular disease (CVD) and type 2 diabetes (T2D). Despite mounting evidence, PTSD is not currently acknowledged as a risk factor by cardiovascular or endocrinological medicine. This view is unlikely to change absent compelling evidence that PTSD causally contributes to cardiometabolic disease. This review suggests that with developments in methods for epidemiological research and the rapidly expanding knowledge of the behavioral and biological effects of PTSD the field is poised to provide more definitive answers to questions of causality. First, we discuss methods to improve causal inference using the observational data most often used in studies of PTSD and health, with particular reference to issues of temporality and confounding. Second, we consider recent work linking PTSD with specific behaviors and biological processes, and evaluate whether these may plausibly serve as mechanisms by which PTSD leads to cardiometabolic disease. Third, we evaluate how looking more comprehensively into the PTSD phenotype provides insight into whether specific aspects of PTSD phenomenology are particularly relevant to cardiometabolic disease. Finally, we discuss new areas of research that are feasible and could enhance understanding of the PTSD-cardiometabolic relationship, such as testing whether treatment of PTSD can halt or even reverse the cardiometabolic risk factors causally related to CVD and T2D.
Quasi-static approach approximation for 6 degrees-of-freedom haptic rendering (2004)

In this paper, we propose a quasi-static approximation (QSA) approach to simulate the movement of the movable object in 6-degrees-of-freedom (DOF) haptic rendering. In our QSA approach, we solve for static equilibrium during each haptic time step, ignoring any dynamical properties such as inertia. The major contribution of this approach is to overcome the computational instability problem in overly stiff systems arising from numerical integration of second-order differential equations in previous dynamic models. Our primary experimental results on both simulated aircraft geometry and a large-scale real-world aircraft engine showed that our QSA approach was capable of maintaining the 1000Hz haptic refresh rate with more robust collision avoidance and more reliable force and torque feedback.
Polarization and Phase-Shifting for 3D Scanning of Translucent Objects (2007)

Translucent objects pose a difficult problem for traditional structured light 3D scanning techniques. Subsurface scattering corrupts the range estimation in two ways: by drastically reducing the signal-to-noise ratio and by shifting the intensity peak beneath the surface to a point which does not coincide with the point of incidence. In this paper we analyze and compare two descattering methods in order to obtain reliable 3D coordinates for translucent objects. By using polarization-difference imaging, subsurface scattering can be filtered out because multiple scattering randomizes the polarization direction of light while the surface reflectance partially keeps the polarization direction of the illumination. The descattered reflectance can be used for reliable 3D reconstruction using traditional optical 3D scanning techniques, such as structured light. Phase-shifting is another effective descattering technique if the frequency of the projected pattern is sufficiently high. We demonstrate the performance of these two techniques and the combination of them on scanning real-world translucent objects.
Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs (2003)

The anti-HIV-1 activity of this oligonucleotide was increased when the phosphodiester and 2'-hydroxyl groups on the oligonucleotide backbones were replaced with a phosphorothioate and 2'-O-methyl backbone; thus Gm3Um4Gm3-s may inhibit HIV-1 infection, at least in part, by blocking the interaction between gp120 and CD4.
Electrophysiological and Morphological Changes in Striatal Spiny Neurons in R6/2 Huntington's Disease Transgenic Mice (2001)

We examined passive and active membrane properties and synaptic responses of medium-sized spiny striatal neurons in brain slices from presymptomatic (approximately 40 days of age) and symptomatic (approximately 90 days of age) R6/2 transgenics, a mouse model of Huntington's disease (HD) and their age-matched wild-type (WT) controls. This transgenic expresses exon 1 of the human HD gene with approximately 150 CAG repeats and displays a progressive behavioral phenotype associated with numerous neuronal alterations. Intracellular recordings were obtained using standard techniques from R6/2 and age-matched WT mice. Few electrophysiological changes occurred in striatal neurons from presymptomatic R6/2 mice. The changes in this age group were increased neuronal input resistance and lower stimulus intensity to evoke action potentials (rheobase). Symptomatic R6/2 mice exhibited numerous electrophysiological alterations, including depolarized resting membrane potentials, increased input resistances, decreased membrane time constants, and alterations in action potentials. Increased stimulus intensities were required to evoke excitatory postsynaptic potentials (EPSPs) in neurons from symptomatic R6/2 transgenics. These EPSPs had slower rise times and did not decay back to baseline by 45 ms, suggesting a more prominent component mediated by activation of N-methyl-D-aspartate receptors. Neurons from both pre- and symptomatic R6/2 mice exhibited reduced paired-pulse facilitation. Data from biocytin-filled or Golgi-impregnated neurons demonstrated decreased dendritic spine densities, smaller diameters of dendritic shafts, and smaller dendritic fields in symptomatic R6/2 mice. Taken together, these findings indicate that passive and active membrane and synaptic properties of medium-sized spiny neurons are altered in the R6/2 transgenic. These physiological and morphological alterations will affect communication in the basal ganglia circuitry. Furthermore, they suggest areas to target for pharmacotherapies to alleviate and reduce the symptoms of HD.
Application of Ionic Liquid Halide Nucleophilicity for the Cleavage of Ethers:  A Green Protocol for the Regeneration of Phenols from Ethers (2004)

We have used the high nucleophilicity of bromide ion in the form of the ionic liquid, 1-n-butyl-3-methylimidazolium bromide ([bmim][Br]), for the nucleophilic displacement of an alkyl group to regenerate a phenol from the corresponding aryl alkyl ether. Using 2-methoxynaphthalene (1) as a model compound, we found that the combination of ionic liquid [bmim][Br] and p-toluenesulfonic acid with warming effected demethylation in 14 h, affording the desired product 2-naphthol (2) in good yield (97%). Various other protic acids (MsOH, hydrochloric acid (35%), dilute sulfuric acid (50%)) could be used as a proton source in this demethylation reaction. Under the same conditions, cleavage of alkyl alkyl ether 2-(3-methoxypropyl)naphthalene yielded mixture of corresponding 2-(3-bromopropyl)naphthalene and 2-(3-hydroxypropyl)naphthalene. Dealkylation of various aryl alkyl ethers could also be achieved using significantly reduced (i.e., stoichiometric) amounts of concentrated hydrobromic acid (47%) in the ionic liquid. Both procedures afforded the desired products in moderate to good yield; however, cleavage of aryl alkyl cyclic ether, 2,3-dihydrobenzofuran, resulted in low yield of the desired product o-2-bromoethylphenol. The convenience of this method for ether cleavage and its effectiveness using only a moderate excess of hydrobromic acid make it attractive as a green chemical method.
Miniature Internal Penta-Band Monopole Antenna for Mobile Phones (2010)

A compact T-slit monopole antenna with slotted ground plane in the mobile phone for penta-band operation is proposed. In this configuration, the antenna comprises a T-slit monopole printed on the top ungrounded portion of an FR4 substrate of small size of 47 × 5.4 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and a slotted ground plane etched on the back side of the substrate of size of 47 × 10 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . In addition, an inverted-L copper strip is soldered to the end edge of the monopole for extending the electrical length of the antenna for GSM band; that is, the proposed antenna occupies a small volume of 47 × 10 × 5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> inside the mobile phone and is suitable to operate as an internal antenna. By controlling the related parameters, the proposed antenna can resonates at different operating bands to cover GSM850/900 and DCS/PCS/UMTS operations independently.
Evaluating Liveness by Face Images and the (2005)

A technique evaluating liveness in short face image se- quences is presented. The intended purpose of the proposed system is to assist in a biometric authentication framework, by adding liveness awareness in a non-intrusive manner. Analysing the trajectories of single parts of a live face reveal valuable information to discriminate it against a spoofed one. The proposed system uses a lightweight novel optical flow, which is especially applicable in face motion estimation based on the structure tensor and a few frames. It uses a model-based local Gabor decomposition and SVM experts for face part detection. An alternative approach for face part detection using optical flow pattern matching is introduced as well. Experimental results on the proposed system are presented.
Maya USA (2010)

By degrees it has come to pass that working men have been surrendered, isolated and helpless, to the hardheartedness of employers and the greed of unchecked competition … To this must be added that the hiring of labor and the conduct of trade are concentrated in the hands of comparatively few; so that a small number of very rich men have been able to lay upon the teeming masses of the laboring poor a yoke little better than that of slavery itself (Pope Leo XIII 1891).
Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization (1993)

A human growth hormone expression construct was delivered intracellularly into the abdominal skin of mice by particle bombardment-mediated gene transfer. Using this technology, the in vivo delivery of antigen-encoding expression vectors affixed to gold microprojectiles results in de novo antigen production in target skin and development of specific antibody responses. In this study, we examined the contribution of various delivery parameters to the resultant protein expression and related antibody responses. The highest levels of both protein expression and antibody production were correlated with particle delivery to the epidermis while deliveries extending into the dermis resulted in decreased protein and antibody production. Optimal immune responses were also shown to be dependent upon the delivery of a sufficient number of DNA-coated gold particles, indicating that a dose-response relationship exists between the number of particles delivered and the resultant protein expression and antibody production. Further, maximal protein expression and associated antibody titers were elicited with surprisingly small amounts of DNA. The practicality of targeting skin and the use of three to four orders of magnitude less DNA than is typically required in direct DNA inoculation studies demonstrates the potential utility of this emerging technology for the rapid production of antibodies in laboratory animals, and in the development of a new class of human clinical vaccines based upon direct, intracellular DNA delivery.
New approaches for the detection of early activation products in thrombotic states. (1986)

The occurrence of a consumption coagulopathy as well as prethrombotic and thrombotic states are connected with the formation of thrombin. The proteinase acts upon physiological substrates leading to activation products, e.g. fibrinopeptides, platelet factors or thrombin-antithrombin III-complex. For the determination of such products we have developed immunochemical assays, which detect parameters of a direct or indirect action of thrombin in a specific and sensitive manner: 1. ELISA for determination of platelet factor 4; 2. Latex-test for determination of D-Dimer; 3. ELISA for determination of thrombin-antithrombin III complex. Preliminary results from clinical investigations indicate that the determination of these parameters can be valuable for the diagnosis of activation processes of the clotting system.
Hematopoietic growth factors and cytokines (1994)

Hematopoietic Growth Factors. Interleukins and Cytokines. Colony-Stimulating Factors. Interferons. Tumor Necrosis Factors. Erythropoietic Growth Factors. Platelet-Derived Growth Factor. Transferrins.
Regio- and Stereoselective Ni-Catalyzed 1,4-Hydroboration of 1,3-Dienes: Access to Stereodefined (Z)-Allylboron Reagents and Derived Allylic Alcohols (2010)

A catalytic regio- and stereoselective 1,4-hydroboration of 1,3-dienes was accomplished with pinacolborane in the presence of Ni(cod)(2) and PCy(3). This reaction exhibits broad substrate scope operating on a range of substituted dienes and occurs with generally high levels of selectivity and efficiency. Reactivity patterns suggest that the reactive conformation of the diene is the S-cis form. The intermediate allylboronate can be oxidized to stereodefined allylic alcohols or can be used in stereoselective carbonyl addition reactions.
Muscarinic M1receptor agonists and M2receptor antagonists as therapeutic targets in Alzheimer’s disease (2002)

AbstractAlzheimer's disease is the most common form of senile dementia and is of increasing medical and economic importance. One of the earliest findings in the systematic study of Alzheimer's disease was the progressive loss of acetylcholinergic neurons. This lead to the so-called cholinergic hypothesis of Alzheimer's disease and provoked a search for cholinergic replacement therapies. This has resulted in compounds capable of inhibiting the catabolism of acetylcholine (acetylcholinesterase inhibitors) being licensed for the treatment of Alzheimer's disease. However, the search for directly acting, selective, muscarinic M1 receptor agonists and M2 receptor antagonists, that are capable of increasing acetylcholine levels in the neocortex, has not yet proved successful. For the muscarinic agonists this failure has been largely due to the difficulty in finding genuinely selective compounds. As a result, there has been a reduction in the number published patents in this area. This review discusses the rationale, progress and the possible future for these two potential approaches to the therapy of Alzheimer's disease especially in light of some recent patents containing selective compounds.KeywordsacetylcholineAlzheimer's diseaseM1 receptor agonistsM2 receptor antagonistsmuscarinic receptors
Comparison of In Vitro Activities of 17 Antifungal Drugs against a Panel of 20 Dermatophytes by Using a Microdilution Assay (2003)

The in vitro activities of 17 antifungal drugs against a panel of 20 dermatophytes comprising 6 different species were determined using a microdilution assay according to the NCCLS M38-P method with some modifications. Terbinafine was the most potent systemic drug while tolnaftate and amorolfine were the most active topical agents.
Phase I Trial of Continuous Infusion Interleukin-2 and Doxorubicin in Patients with Refractory Malignancies (1991)

A phase I trial was performed to assess the immunomodulatory activities, maximum tolerated doses, and the toxicity of recombinant interleukin-2 (rIL-2) administered in combination with doxorubicin to patients with refractory malignancies. Therapy was administered to successive cohorts of four to six patients who were treated at three different dose levels (1A, 1B, 2A). Levels 1-2 refer to doxorubicin (40 or 60 mg/m2) given as an intravenous (i.v.) bolus on day 1, and levels A-B refer to rIL-2 (1.0 or 3.0 x 10(6) U/m2) given as a continuous i.v. infusion on days 2-5, 9-12, and 16-19. Cycles were repeated every 28 days. Seventeen patients were entered in the trial. Dose limiting toxicity consisted of neutropenia, and the maximum tolerated dose (MTD) of the combination was doxorubicin 40 mg/m2 and rIL-2 3.0 x 10(6) U/m2. No objective responses were observed. Lymphocytosis related to rIL-2 occurred and flow cytometry demonstrated significant increases in the following subsets: CD3+CD25+HLADr+ and CD11b-CD16c+CD8-. Natural killer cell activity and lymphokine-activated killer (LAK) cell precursors were increased in patients treated at dose levels 1A and 1B (40 mg/m2 doxorubicin), but no consistent changes in LAK activity were noted. No clinical responses were seen and the overall toxicity of this combination was moderate to severe. Administration of doxorubicin prior to rIL-2 does not enhance the immunologic effects of rIL-2.
Hydroaminoalkylation of Unactivated Olefins with Dialkylamines (2008)

The intermolecular addition of the alpha-C-H bonds of unactivated dialkylamines to unactivated olefins in the presence of the chloro amido complex [TaCl3(NEt2)2]2 (2) is described. This process forms the branched insertion products in high yields (up to 96%) and selectivities, and represents a rare example of an intermolecular amine-olefin coupling reaction that does not require preactivation of either substrate. The reaction is shown to encompass the addition of the primary C-H bonds in linear- and branched-methylamines, as well as secondary C-H bonds in higher dialkylamines. The related chloroanilido complex [TaCl3(NMePh)2]2 (4) is also shown to catalyze the addition of N-alkyl-arylamines to olefins at temperatures as low as 90 degreesC. 1H NMR spectroscopy, identification of the catalyst structure, and deuterium-labeling experiments all suggest that reactions catalyzed by 2 and 4 occur by turnover-limiting generation of an eta2-imine complex. These labeling studies also imply that more favorable partitioning of the eta2-imine complex toward reaction with alkene versus regeneration of the starting bis-amido complex accounts for the higher reactivity of the mixed halide amido catalyst versus a homoleptic amido complex.