gebhart/patrepeval huggingface dataset:
Viability and Function of Stored Sickle Erythrocytes (1980)

Functional and metabolic characteristics of fresh and three-week stored erythrocytes from patients with sickle cell anemia were compared. The storage-related changes in ATP, 2,3-DPG, and P50 in sickle erythrocytes were similar to those in control (HbA) red blood cells. After storage in CPD, sickle erythrocytes maintained significantly higher levels of 2,3-DPG (mean 2.20 +/- 0.73 mM/ml RBC) than did control cells (mean 0.36 +/- 0.13 mM/ml RBC). The posttransfusion recovery and survival of stored SS erythrocytes in autologous recipients and in an animal test system were at least as good as those before storage. Tolerance of the storage lesion by sickle erythrocytes is probably related to their young mean cell age. These results also suggest that the option of autotransfusion should be explored for selected patients with sickle cell disease in special clinical settings.
Iron-Catalyzed 1,4-Hydroboration of 1,3-Dienes (2009)

A chemo-, regio-, and stereoselective iron-catalyzed 1,4-hydroboration of dienes that affords gamma-disubstituted allylboranes has been developed. 1,4-Hydroboration of 2-substituted dienes forms allylborane products with (E)-trisubstituted double bonds exclusively.
Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction (2011)

The reaction of [1.1.1]propellane with di-tert-butyl azodicarboxylate and phenylsilane in the presence of Mn(dpm)(3) to give di-tert-butyl 1-(bicyclo[1.1.1]pentan-1-yl)hydrazine-1,2-dicarboxylate is described. Subsequent deprotection gives 1-bicyclo[1.1.1]pentylhydrazine followed by reduction to give 1-bicyclo[1.1.1]pentylamine. The reported route marks a significant improvement over the previous syntheses of 1-bicyclo[1.1.1]pentylamine in terms of scalability, yield, safety, and cost.
Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides. (1982)

Fibroblasts are known to have chemotactic responses to two components of the extracellular matrix, collagen and fibronectin. To extend these observations to other extracellular connective tissue macromolecules and their proteolytic fragments, fibroblasts from adult human skin and from late-gestation (270 d), fetal bovine ligaments were studied for chemotactic responsiveness to tropoelastin and elastin-derived peptides. Bovine ligament tropoelastin and elastin-derived peptides, generated from either human aortic elastin with human neutrophil elastase or from bovine ligament elastin with pancreatic elastase, elicited chemotactic responses that were maximal at 0.2 micrograms/ml (3 X 10(-9) M) and 0.5-2.0 micrograms protein/ml, respectively. Fractionation of the elastin-derived peptides by gel filtration (Bio-Gel P-10) indicated that comparable levels of chemotactic activity were present in all fractions, and amino acid analysis of the fractions showed no relationship between chemotactic activity and desmosine concentration. Taken in conjunction with the observations on tropoelastin, it appears that fibroblast chemotaxis to elastin components does not involve the cross-links of elastin. These results demonstrate that the influences of the connective tissue matrix upon fibroblast migration might include elastin precursors and fragments of elastin.
Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens (1998)

Little is known about the function of human cancer/testis antigens (CTAs), such as MAGE, BAGE, GAGE, HOM-MEL-40, and NY-ESO-1, the expression of which is restricted to human malignancies and testis. When screening a cDNA expression library enriched for testis-specific representative long transcripts for reactivity with high-titered IgG antibodies from the serum of a patient with renal cell carcinoma, one repeatedly detected antigen, designated HOM-TES-14, turned out to be encoded by the synaptonemal complex protein 1 (SCP-1) gene. SCP-1 is known to be selectively expressed during the meiotic prophase of spermatocytes and is involved in the pairing of homologous chromosomes, an essential step for the generation of haploid cells in meiosis I. Investigation of a broad spectrum of normal and malignant tissues revealed expression of SCP-1 transcripts and antigen selectively in a variety of neoplastic tissues and tumor cell lines. Immunofluorescence microscopy analysis with specific antiserum showed a cell cycle phase-independent nuclear expression of SCP-1 protein in cancer cells. SCP-1 differs from other members of the class of CTA by its localization on chromosome 1 and its frequent expression in malignant gliomas, breast, renal cell, and ovarian cancer. The aberrant expression of SCP-1 in tumors might contribute to their genomic instability and suggests that the functional role of other CTA might also relate to meiosis.
Intrapulmonary Delivery of XCL1-Targeting Small Interfering RNA in Mice Chronically Infected with Mycobacterium tuberculosis (2008)

Mice infected for 60 days with Mycobacterium tuberculosis were treated with aerosolized XCL1-targeting small interfering RNA (siRNA) to induce local and transient suppression of XCL1/lymphotactin (an important chemokine in tuberculoid granuloma formation). The local pulmonary siRNA therapy resulted in a 50% decrease in the total amount of xcl1 gene transcripts at 3 days, and 40 to 50% protein suppression 3 and 5 days after treatment. Reduced XCL1 expression in the lungs was associated with decreased numbers of T lymphocytes, reduction in the IFN-gamma response, disorganized granulomatous lesions, and higher fibrosis when compared with control mice treated with either PBS or nontargeting siRNA. This indicates that a transient but strong modulation of the production of XCL1 in the lungs has a significant effect on the influx of IFN-gamma-secreting T cells, as well as local pathology, but without significantly altering containment of the infection.
Mapping the Physiological Parameters of Articular Cartilage with Magnetic Resonance Imaging (1999)

The ability of magnetic resonance imaging (MRI) to visualize the spatial distribution of parameters related to the physiological and structural properties of tissues makes it an ideal tool for the study of articular cartilage. A variety of ingenious MRI methods have been devised to probe the complex composition and biochemistry of normal and degenerate articular cartilage. In this article we review the current status of this research and pose some questions concerning the future directions of articular cartilage research and clinical applications.
Unsupervised Machine Learning for Networking: Techniques, Applications and Research Challenges (2019)

While machine learning and artificial intelligence have long been applied in networking research, the bulk of such works has focused on supervised learning. Recently, there has been a rising trend of employing unsupervised machine learning using unstructured raw network data to improve network performance and provide services, such as traffic engineering, anomaly detection, Internet traffic classification, and quality of service optimization. The growing interest in applying unsupervised learning techniques in networking stems from their great success in other fields, such as computer vision, natural language processing, speech recognition, and optimal control (e.g., for developing autonomous self-driving cars). In addition, unsupervised learning can unconstrain us from the need for labeled data and manual handcrafted feature engineering, thereby facilitating flexible, general, and automated methods of machine learning. The focus of this survey paper is to provide an overview of applications of unsupervised learning in the domain of networking. We provide a comprehensive survey highlighting recent advancements in unsupervised learning techniques, and describe their applications in various learning tasks, in the context of networking. We also provide a discussion on future directions and open research issues, while identifying potential pitfalls. While a few survey papers focusing on applications of machine learning in networking have previously been published, a survey of similar scope and breadth is missing in the literature. Through this timely review, we aim to advance the current state of knowledge, by carefully synthesizing insights from previous survey papers, while providing contemporary coverage of the recent advances and innovations.
Use of the Tetracycline-controlled Transcriptional Silencer (tTS) to Eliminate Transgene Leak in Inducible Overexpression Transgenic Mice (2001)

The doxycycline-inducible reverse tetracycline transactivator (rtTA) is frequently used to overexpress transgenes in a temporally regulated fashion in vivo. These systems are, however, often limited by the levels of transgene expression in the absence of dox administration. The tetracycline-controlled transcriptional silencer (tTS), a fusion protein containing the tet repressor and the KRAB-AB domain of the kid-1 transcriptional repressor, is inhibited by doxycycline. We hypothesized that tTS would tighten control of transgene expression in rtTA-based systems. To test this hypothesis we generated mice in which the CC10 promoter targeted tTS to the lung, bred these mice with CC10-rtTA-interleukin 13 (IL-13) mice in which IL-13 was overexpressed in an inducible lung-specific fashion, and compared the IL-13 production and phenotypes of parental mice and the triple transgenic CC10-rtTA/tTS-IL-13 progeny of these crosses. In the CC10-rtTA-IL-13 mice, IL-13, mucus metaplasia, inflammation, alveolar enlargement, and enhanced lung volumes were noted at base line and increased greatly after doxycycline administration. In the triple transgenic tTS animals, IL-13 and the IL-13-induced phenotype could not be appreciated without doxycycline. In contrast, tTS did not alter the induction of IL-13 or the generation of the IL-13 phenotype by doxycycline. Thus, tTS effectively eliminated the baseline leak without altering the inducibility of rtTA-regulated transgenes in vivo. Optimal "off/on" regulation of transgene expression can be accomplished with the combined use of tTS and rtTA.
LEAF OF ALOE VERA IN TREATMENT OF ROENTGEN RAY ULCERS (1937)

The treatment of roentgen ray and radium ulcers with the fresh whole leaf of Aloe vera was first described by Collins and Collins<sup>1</sup>in 1935. Wright<sup>2</sup>in 1936 published an additional report on its use, stating that he had obtained gratifying results. The technic of application of both the fresh whole leaf and an ointment containing the intestinal contents of the leaf have been described by these men. Since the publication of these two papers many patients have undoubtedly been treated by this method. For the most part, however, the results are relatively unknown, since cases in which that treatment was used have been reported only by word of mouth or in the transactions of certain societies.<sup>3</sup> Any one who has seen the horrible suffering endured by patients with some of the late sequelae of roentgen and radium irradiation and who realizes the utter futility of previous
A stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep syntheses (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stable and easily prepared catalyst for the enantioselective reduction of ketones. Applications to multistep synthesesE. J. Corey, Raman K. Bakshi, Saizo Shibata, Chung Pin Chen, and Vinod K. SinghCite this: J. Am. Chem. Soc. 1987, 109, 25, 7925–7926Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ja00259a075https://doi.org/10.1021/ja00259a075research-articleACS PublicationsRequest reuse permissionsArticle Views11381Altmetric-Citations799LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Addition of an Alginate to a Modified Zeolite Improves Hemostatic Performance in a Swine Model of Lethal Groin Injury (2009)

Application of the compound zeolite hemostat can effectively control hemorrhage and dramatically reduce mortality from a lethal groin wound. In addition to its antibacterial properties, Ag- and Zn-substituted zeolite hemostat can decrease the exothermic reaction and greatly attenuate the heat-induced tissue injury.
Demethylation of DNA by decitabine in cancer chemotherapy (2004)

Genes involved in all aspects of tumor development and growth can become aberrantly methylated in tumor cells, including genes involved in apoptosis and cell cycle regulation. Decitabine, 2'-deoxy-5-azacytidine, can inhibit DNA methyltransferases and reverse epigenetic silencing of aberrantly methylated genes. Nucleoside DNA methyltransferase inhibitors, such as decitabine, have been reported to have antitumor activity, especially against hematologic malignancies. Such demethylating agents have been proposed to reactivate tumor suppressor genes aberrantly methylated in tumor cells, leading to inhibition of tumor growth. An important consequence of this is that, unlike conventional cytotoxic agents, it may be best to use such drugs at concentrations lower than the maximum tolerated dose and in a manner dependent on their demethylating activity. Furthermore, synergistic activity with other types of investigational epigenetic therapies and existing chemotherapies opens the possibility of rational combinations and scheduling of these agents based on their biologic activity.
Dielectric Integrity of High-Temperature Nanocomposites (2008)

The addition of nanoscale metal oxide fillers to polymers has been shown, in many cases, to lead to an improvement in the dielectric breakdown strength and voltage endurance. In this paper, dielectric properties for silica- and alumina-filled polyamideimide (PAI) thin films are reported as a function of particle loading. The dispersion and thermal behavior are quantified. Experiments were also conducted using particulates which were functionalized with Aminopropyltriethoxysilane in order to augment the chemical bonding to the host matrix. The glass transition temperature and decomposition temperature are reported as a function of nanoparticle type and loading. The dielectric strength is provided for both AC and DC voltages. It was found that the enhancement in breakdown strength for a nanocomposite formulation is greater under DC conditions than AC. In addition, alumina filled PAI was found to exhibit greater electrical breakdown strength than silica filled PAI. A discussion of possible reasons is included.
Management education in Hong Kong: needs and challenges (1995)

Examines Hong Kong′s current requirements in terms of management training and development against the various challenges to be met in providing for those needs. Much of the available training material is produced by Western theorists and practitioners and aimed at Western consumers. The problems involved in transferring such material to the Hong Kong context far exceed those of language and translation. Considerable cultural gaps have to be narrowed, not only in adapting the training material to ensure its relevance, but also in matters of style of delivery, in order to meet the training needs of today′s Chinese students of management.
PRODUCTION OF CO AND CH4 IN ELECTROCHEMICAL REDUCTION OF CO2 AT METAL ELECTRODES IN AQUEOUS HYDROGENCARBONATE SOLUTION (1985)

Abstract The total analysis of gaseous and soluble products was carried out in the electrochemical reduction of CO2 (current density 5 mA cm−2) on various electrode metals. HCOO− was predominantly produced at Cd, In, Sn, and Pb cathodes. Ag and Au principally gave CO. CH4 was formed in an appreciable amount at Cu cathode.
Clinical Efficacy in the Treatment of Overactive Bladder Refractory to Anticholinergics by Posterior Tibial Nerve Stimulation (2012)

PTNS is a valid, minimally invasive treatment option with minimum morbidity for patients with OAB refractory to treatment with anticholinergics.
VisGuides: A Forum for Discussing Visualization Guidelines (2018)

This paper presents VisGuides, a discussion platform to facilitate the collection, evaluation, critique, revision, and dissemination of visualization guidelines. As visualization becomes a more widespread discipline with much more attention by designers and the general public, we need to ensure mechanisms for communicating, transferring, and accessing visualization knowledge. A visualization guideline can be anything ranging from good practices, empirical studies, and survey reports with the goal to inform visualization design and understanding. Thus, our forum aims (i) to collect visualization guidelines, (ii) to discuss guidelines and collect respective empirical references, and in the long run, (iii) to establish formal knowledge about guidelines by analyzing the forum content and the consensus of discussions. This paper describes the VisGuides forum and outlines our preliminary research towards shedding more light on visualization guidelines. VisGuides is accessible online at visguides.org.
Reaction of Organic Compounds with Hydrazine. XI (1962)

Reductive action of hydrazine hydrate on quinones was examined and systematic reduction was carried out on 16 kinds of various substituted quinones by which the corresponding hydroxyl compounds were obtained in a good yield. This reduction did not cause any side reaction even in quinones with functional groups and hydrazine hydrate was found to be a mild agent, better suited than the existing reducing agents.
Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis (1984)

Twenty-two of 32 sporadic cases of amyotrophic lateral sclerosis had argyrophilic spheroids, 20 micrometers or larger, in the anterior horns of the spinal cords. The fine structure of these spherical bodies was characterized by interwoven, small bundles of 10 nm neurofilaments. Scattered mitochondria, vesicles and fragments of smooth endoplasmic reticulum were commonly found among the bundles of neurofilaments. The spheroids were present not only in the myelinated axons, but also in the perikarya of the anterior horn cells. In anterior horn neurons occasional fragments of rough endoplasmic reticulum, lipofuscin and even nuclei were found among the neurofilaments, in addition to the other components. Rarely, some filamentous accumulations contained unusual features such as paracrystalline arrays, polyglucosan bodies and honeycomb-like structures. Linear densities, associated with ribosome-like particles, were found scattered within focal collections of randomly arranged neurofilaments in some perikarya of two cases. Occasional mitochondria with regularly arranged short protrusions on the outer membrane were observed in the myelinated axons in one case.
Human papilloma virus detection by in situ hybridisation signal amplification based on biotinylated tyramine deposition (1996)

Aim-To describe a method for amplifying human papilloma virus (HPV) in situ hybridisation (ISH) signals.Methods-Three human cervical cell lines, namely CaSKi, HeLa and SiHa, containing different copy numbers of integrated HPV DNA were studied. Following ISH, catalysed reporter deposition (CARD), based on the deposition of biotinylated tyramine at the location of the DNA probe, was used to amplify the ISH signal.Results-Using CARD-ISH, one to three HPV type 16 copies were detected in situ both in cell suspensions and paraffin wax sections of SiHa cells. CARD-ISH can also be used to detect oncogenic HPV DNA sequences, such as HPV types 16 and 18, in routinely processed formalin fixed, paraffin wax embedded cervical specimens.Conclusions-CARD-ISH is a fast and highly sensitive ISH method for the routine detection of low copy number HPV DNA sequences in cervical cell lines and routinely processed tissue sections. Application of this technology also enables the routine detection and cellular localisation of other viral DNA sequences present at copy numbers below the detection limit of conventional ISH methods.
Chip‐based microfluidic devices coupled with electrospray ionization‐mass spectrometry (2005)

We present the current status of the development of microfluidic devices fabricated on different substrates for coupling with electrospray ionization-mass spectrometry (ESI-MS). Until now, much success has been gained in fabricating the ESI chips, which show better performances due to miniaturization when compared with traditional methods. Integration of multiple steps for sample preparation and ESI sample introduction, however, remains a great challenge. This review covers the main technical development of electrospray device that were published from 1997 to 2004. This article does not attempt to be exclusive. Instead, it focuses on the publications that illustrated the breath of the development and applications of microchip devices for MS-based analysis.
Discovery is never by chance (2009)

Serendipity has a long tradition in the history of science as having played a key role in many significant discoveries. Computer scientists, valuing the role of serendipity in discovery, have attempted to design systems that encourage serendipity. However, that research has focused primarily on only one aspect of serendipity: that of chance encounters. In reality, for serendipity to be valuable chance encounters must be synthesized into insight. In this paper we show, through a formal consideration of serendipity and analysis of how various systems have seized on attributes of interpreting serendipity, that there is a richer space for design to support serendipitous creativity, innovation and discovery than has been tapped to date. We discuss how ideas might be encoded to be shared or discovered by 'association-hunting' agents. We propose considering not only the inventor's role in perceiving serendipity, but also how that inventor's perception may be enhanced to increase the opportunity for serendipity. We explore the role of environment and how we can better enable serendipitous discoveries to find a home more readily and immediately.
DC Gas-Discharge Display Panel with LaB6 Thin-Film Cathode (1987)

A dc gas-discharge display panel with LaB 6 thin-film cathodes is proposed for data information systems. A thin-film, having a crystallographic orientation of [100], was formed on a Ni thick-film using the electron-beam evaporation technique. The low work function of the crystallographic orientation provided a low operating voltage. The normal cathode fall potential for the thin-film cathode in a Ne+Ar (0.4%) gas discharge was approximately 80 V, about 1/2 that of the commonly used Ni thick-film cathode. The display panel consisted of two glass plates: cathodes were formed on one plate (substrate) and anodes on the other. The cathodes and anodes were perpendicular to each other, and were separated by barriers formed in parallel between the anodes. Low voltage, high luminance, high luminous efficiency and stable operation were attained without the use of Hg.