gebhart/patrepeval huggingface dataset:
전남 지역 일부 대학생의 음료섭취실태와 관련요인 연구 (2016)

Objectives: The purpose of the study was to investigate the beverage consumption and related factors of undergraduates in Jeonnam. Methods: A self-reported questionnaire was completed by 480 undergraduates in Jeonnam from June 1 to 15, 2016 based on convenience sampling. The questionnaire consisted of general characteristics of the subjects, beverage intake frequency, and awareness of beverage. Results: Carbonated beverage intake was 3.05 times per week and five kinds of beverage consumption was 12.48 times per week. Higher beverage intake was closely related to male students, higher beverage purchase, and lower awareness toward oral health impact by beverage and sugar contents. Conclusions: The recognition level of beverage related to oral health had an impact on the frequency of drink intake. It is necessary to educate the dietary guide for appropriate oral health management in beverage intake.
Colorful Image Colorization (2016)

Given a grayscale photograph as input, this paper attacks the problem of hallucinating a plausible color version of the photograph. This problem is clearly underconstrained, so previous approaches have either relied on significant user interaction or resulted in desaturated colorizations. We propose a fully automatic approach that produces vibrant and realistic colorizations. We embrace the underlying uncertainty of the problem by posing it as a classification task and use class-rebalancing at training time to increase the diversity of colors in the result. The system is implemented as a feed-forward pass in a CNN at test time and is trained on over a million color images. We evaluate our algorithm using a "colorization Turing test," asking human participants to choose between a generated and ground truth color image. Our method successfully fools humans on 32% of the trials, significantly higher than previous methods. Moreover, we show that colorization can be a powerful pretext task for self-supervised feature learning, acting as a cross-channel encoder. This approach results in state-of-the-art performance on several feature learning benchmarks.
Monoclonal antibody-defined human pancreatic cancer-associated antigens. (1985)

Three pancreatic cancer-associated antigens were characterized by use of monoclonal antibodies in immunobinding studies with various cellular and soluble target antigens, in immunoprecipitation, and in immunoperoxidase staining. C54-0 represents a tumor-associated Mr 122,000 antigen, which appears to be widely distributed on various epithelial tumors and to a lower extent on normal tissue. C1-N3 antigen exhibited a more restricted distribution, reacting with pancreatic and various gastrointestinal tract tumors as well as with chronically inflamed pancreatic tissue. The most specific antigen expression was observed for C1-P83 antigen, found on all exocrine tumors of the pancreas, but not on normal or chronically inflamed pancreatic tissue.
Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. (2001)

All individuals with Down syndrome (DS) eventually develop the neuropathology of Alzheimer's disease (AD), which is characterized by a premature loss of basal forebrain cholinergic neurons. Similarly, between 4 and 6 months of age, Ts65Dn mice, which model DS, lose cholinergic markers in their medial septal neurons. It is not known whether Ts65Dn mice have age-related learning deficits as well. Control and Ts65Dn mice were tested at several ages in context discrimination. Controls at all ages showed no deficits in learning this task. Ts65Dn mice younger than 3 months demonstrated impaired learning, suggesting a possible developmental delay in Ts65Dn mice. Four-month-old Ts65Dn mice showed no deficits, whereas Ts65Dn mice older than 5 months were impaired in learning the task. Therefore, Ts65Dn mice have an age-related learning impairment that coincides with their age-related neuroanatomical abnormalities and, consequently, may be a useful model of AD.
The MIP Family of Integral Membrane Channel Proteins: Sequence Comparisons, Evolutionary Relationships, Reconstructed Pathway of Evolution, and Proposed Functional Differentiation of the Two Repeated Halves of the Proteins (1993)

The major intrinsic protein (MIP) of the bovine lens fiber cell membrane was the first member of the MIP family of proteins to be sequenced and characterized. It is probably a homotetramer with transmembrane channel activity that plays a role in lens biogenesis or maintenance. The polypeptide chain of each subunit may span the membrane six times, and both the N- and C-termini face the cell cytoplasm. Eighteen sequenced or partially sequenced proteins from bacteria, yeast, plants, and animals have now been shown to be members of the MIP family. These proteins appear to function in (1) metazoan development and neurogenesis (MIP and BIB), (2) water transport across the human erythrocyte membrane (ChIP), (3) communication between host plant cells and symbiotic nitrogen-fixing bacteria (NOD), (4) transport across the tonoplast membrane during plant seed development (alpha-TIP), (5) water stress-induced resistance to desiccation in plants (Wsi-TIP), (6) suppression of a genetic growth defect on fermentable sugars in yeast (FPS1), and (7) transport of glycerol across bacterial cell membranes (GlpF). One other sequenced member of the MIP family (ORF1 of Lactococcus lactis) has no known physiological function. The biochemical functions of the eukaryotic proteins are not well established. Computer analyses have revealed that the first and second halves of all MIP family proteins probably arose by a tandem, intragenic, duplication event. Thus, the primary structure of putative transmembrane helices 1 to 3 is similar to that of putative transmembrane helices 4 to 6 even though they are of opposite orientation in the membrane. Among the most conserved residues in these two repeated halves are a membrane-embedded glutamate (E) in helices 1 and 4, an asparagine-proline-alanine (NPA) sequence in the loops between helices 2 and 3 (cytoplasmically localized) and helices 5 and 6 (extracellularly localized), and a glycine within helices 3 and 6. Statistical analyses suggest that the two halves of these proteins have evolved to serve distinct functions: the first half is more important for the generalized or common functions of these proteins, while the second half of these proteins is more differentiated to provide specific or dissimilar functions of the proteins. The apparent origin of MIP family proteins by duplication of a three-spanner precursor protein suggests an evolutionary origin distinct from other transport proteins with six transmembrane spanners.(ABSTRACT TRUNCATED AT 400 WORDS)
Structural Requirements for Biological Activity of the Ninth and Tenth FIII Domains of Human Fibronectin (1997)

The ninth and tenth type III domains of fibronectin each contain specific cell binding sequences, RGD in FIII10 and PHSRN in FIII9, that act synergistically in mediating cell adhesion. We investigated the relationship between domain-domain orientation and synergistic adhesive activity of the FIII9 and FIII10 pair of domains. The interdomain interaction of the FIII9-10 pair was perturbed by introduction of short flexible linkers between the FIII9 and FIII10 domains. Incremental extensions of the interdomain link between FIII9 and FIII10 reduced the initial cell attachment, but had a much more pronounced effect on the downstream cell adhesion events of spreading and phosphorylation of focal adhesion kinase. The extent of disruption of cell adhesion depended upon the length of the interdomain linker. Nuclear magnetic resonance spectroscopy of the wild type and mutant FIII9-10 proteins demonstrated that the structure of the RGD-containing loop is unaffected by domain-domain interactions. We conclude that integrin-mediated cell adhesion to the central cell binding domain of fibronectin depends not only upon specific interaction sites, but also on the relative orientation of these sites. These data have implications for the molecular mechanisms by which integrin-ligand interactions are achieved.
Two-tone optical heterodyne spectroscopy using buried double heterostructure lead–salt diode lasers (1988)

Two-tone optical heterodyne detection using single mode buried double heterostructure lead-salt diode lasers is studied. Residual amplitude modulation with these lasers is found to be substantially smaller than has been noted in previous work with mesa stripe lasers, permitting improved sensitivity for measurement of small optical absorption. Minimum detectable absorption well below 10(-5) is measured at a laser power of 3 microW, in good agreement with signal-to-noise calculations using the experimental values of the FM and AM modulation indices. Optical heterodyne detection with two-tone modulation at 145 and 155 MHz is found to be nearly an order of magnitude more sensitive than conventional second harmonic detection at kilohertz frequencies. In addition to improved detection sensitivity, the double heterostructure lasers offer the important advantages of single mode operation above liquid nitrogen temperature.
A Cost-Effective Scheme of High-Radix Optical Burst Switch Based on Fast Tunable Lasers and Cyclic AWG (2012)

This paper proposes a new scheme using single N×N cyclic AWG and fast tunable lasers to realize a high-radix kN×kN optical burst switch, which is cost-effective compared with kN×kN AWG and cascaded N×N AWGs schemes.
Tautomerism in N-Heterocycles. IV. Pyrazino[2,3-d]pyridazine-5,8-diol (1979)

Pyrazino[2,3-d]pyridazine-5,8-diol as the neutral molecule in aqueous solution has been shown to exist predominantly as 8-hydroxypyrazino[2,3-d]pyridazin-5(6 H )-one by comparison of its u.v.spectra and p K a values with those of N - and O -methyl derivatives.
Designing a Physical Aid to Support Active Reading on Tablets (2015)

Tablet computers and portable eReaders are gradually becoming the preferred platform for the consumption of textual materials. However, although these technologies are powerful, it is widely acknowledged that print documents better support the advanced active reading tasks necessary to gain a deep understanding of a text. While prior work to address this issue has aimed improve digital eReaders by either leveraging familiar physical affordances or by extending paper's capabilities with digital tools, in this paper we propose a juncture of these two approaches. We first present a formative study that captures the needs and requirements of users during active reading tasks with tablets. We instantiate the findings in the design of a simple physical aid to support active reading: a smart bookmark. We then define an interaction space for this device, describe a set of interfaces designed to facilitate active reading and close with a user study that assesses the potential of the bookmark device and interaction techniques.
The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation (2008)

Idiopathic pneumonia syndrome (IPS) refers to a diffuse, noninfectious, acute lung injury after hematopoietic stem cell transplantation. Historically, IPS is associated with respiratory failure and mortality rates exceeding 50%. Preclinical studies have implicated tumor necrosis factor-alpha as an important effector molecule in the development of disease. We studied the tumor necrosis factor-alpha inhibitor, etanercept, combined with corticosteroids in treating 15 patients (median age, 18 years; range, 1-60 years) with IPS. Eight of 15 patients required mechanical ventilation at therapy onset. Etanercept was administered subcutaneously at a dose of 0.4 mg/kg (maximum 25 mg) twice weekly, for a maximum of 8 doses. Therapy was well tolerated with no infectious pulmonary complications noted. Ten of 15 patients had a complete response, defined as the ability to discontinue supplemental oxygen support during study therapy. The median time to complete response was 7 days (range, 3-18 days), with a day 28 survival of 73%. IPS onset was associated with elevations of several inflammatory proteins in the bronchoalveolar lavage fluid and plasma, and response to therapy correlated with reductions in pulmonary and systemic inflammation. The combination of etanercept and corticosteroids is safe and is associated with high response rates and improved survival in patients with IPS.
Biochemical and growth inhibitory effects of the erythro and threo isomers of gamma-fluoromethotrexate, a methotrexate analogue defective in polyglutamylation. (1989)

We previously reported (J. Galivan et al., Proc. Natl. Acad. Sci. USA, 82: 2598-2602, 1985) the synthesis and characterization of DL-erythro,threo-gamma-fluoromethotrexate (FMTX). The individual diastereomers, DL-erythro-FMTX (eFMTX) and DL-threo-FMTX (tFMTX), and their radiolabeled counterparts have now been prepared and characterized. Transport of eFMTX (Km = 9.3 microM; Vmax = 7.5 pmol/min/10(7) cells) was similar to that of methotrexate (MTX: Km = 6.6-9.9 microM; Vmax = 11.4-14.2 pmol/min/10(7) cells), while tFMTX (Km = 65.1 microM; Vmax = 8.4 pmol/min/10(7) cells) was transported less efficiently. Both isomers were able to saturate intracellular dihydrofolate reductase and accumulate further as unbound intracellular drug. Based on competition experiments and studies with MTX transport-defective cell lines, both isomers utilized the reduced folate/MTX transport system. Efflux half-times for the isomers were similar to those of MTX. Each isomer was equivalent to MTX in its ability to inhibit dihydrofolate reductase activity and bind to intracellular dihydrofolate reductase when the intracellular drug concentration was limiting. Both isomers had drastically diminished capacity to be metabolized to poly(gamma-glutamyl) metabolites by isolated folylpolyglutamate synthetase and in whole cells; tFMTX was metabolized to a slightly lesser extent than eFMTX. Using the CCRF-CEM human leukemia and H35 rat hepatoma cell lines, the growth-inhibitory effects of eFMTX were almost the same as those of MTX during continuous exposure, while tFMTX was slightly less potent. This difference in growth-inhibitory potency of the two isomers correlated with their ability to inhibit de novo thymidylate synthesis in the H35 cell line. These results indicate that both diastereomers of FMTX are similar in their properties to MTX, except that both are incapable of being readily converted to polyglutamate derivatives. As a result of these properties, both isomers could be used under appropriate conditions in comparative studies with MTX to define the roles of MTX polyglutamates.
RETRACTED: RNA-Mediated Synthesis of Palladium Nanoparticles on Au Surfaces (2006)

RNA catalysts for the shape-controlled synthesis of Pd particles from the precursor complex trisdibenzylideneacetone dipalladium ([Pd2(DBA)3] were recently discovered in our laboratory (J. Am. Chem. Soc. 2005, 127, 17814-17818). In the work described here, RNA codes for hexagonal Pd platelets and Pd cubes were covalently immobilized on gold surfaces and evaluated for their activity toward particle synthesis. When coupled to gold via oligoethylene glycol linkers, both RNA sequences were able to catalyze the formation of Pd particles with the same shape control previously observed in solution. For low surface coverages, the average distance between RNA molecules on the surface was estimated at ca. 300 nm, yet large (e.g., dimensions of hundreds of nanometers) Pd hexagons and cubes still formed. This surprising result suggests that a single RNA molecule may be sufficient for nucleating and controlling the shapes of these particles. Finally, the use of surface-bound RNA as a tool for directing the orthogonal synthesis of materials on surfaces was demonstrated. Patterning the RNA code for Pd hexagons next to the code for Pd cubes, followed by incubation in a solution containing [Pd2(DBA)3], resulted in the spontaneous formation of spatially distinct spots of hexagonal and cubic particles.
Micro Electro Thermo Fluidic (METF) liquid microprocessor (2002)

A liquid microprocessor concept based on a new actuator principle is introduced for a true automation of liquid handling in chemical analysis. Silicon microvalves do not satisfy the requirements of an absolute leaktightness, a zero functional dead volume, particle tolerance and reliability providing unlimited working life which requirements are met with Micro Electro Thermo Fluidic (METF) valves. Other beneficial features are no moving part reliability, very small size in comparison to flow resistance, noncontact sensing of valve position. METF actuator principle is a phase change between liquid and solid within the controlled liquid itself, thus requiring extra costs, a special heat sink. Liquid microprocessor architecture utilizes partition of functions for reliable integration. The five logic positions of METE valves form a "microcode" for simple programming of liquid processing steps. Hydraulic liquid dispensing in METF liquid processor eliminates surface tension errors and makes possible nanoliter liquid processing. The high reliability of hermetic liquid processing functions and inherent sensing and control of each METE step opens a true miniaturization and automation potential for chemical and biochemical analysis.
Animal illness and human emotion. Decision-making concerning pets with loss of autonomic function. (1991)

Appropriate communication with clients is essential when dealing with pets that have conditions associated with loss of autonomic function. These conditions include fecal and urinary incontinence, megaesophagus, and feline constipation. These conditions require a strong commitment to long-term caretaking with frequent frustrations on behalf of the client. Evaluation of the owner's personality types as well as the entire home situation is essential in assisting clients with their decision on how to deal with the problems. Each case should be evaluated based on multiple factors. Ideally, the veterinarian needs to go beyond offering medical advice and should help facilitate the decision-making process based on the ability of the client to deal with the care of a pet with a chronic problem. Different approaches to dealing with these often difficult situations will be discussed.
Optical tap array using distributed-index planar microlens (1982)

The letter describes a novel optical tap array by using a two-dimensional array of planar microlenses. The present device is used to monitor a part of light which is transmitted through optical fibres. Planar microlenses to focus the light have been monolithically fabricated by the use of the electromigration technique; the focal length is 3 mm and NA is 0.15. The coupling efficiency of the initial device was 52% for coupling multimode graded-index fibres.
Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture (1971)

✓ Rat glial tumors, induced by weekly injections of N-nitrosomethylurea for 8 months, were plated and propagated in culture. Cells grew as a glial tumor when injected back into various sites in newborn rats, and were then carried for many generations by transplantations from rat to rat or by alternate culture and animal passage. Light, phase, and electron microscopy of the cultured cells showed great variability among the glial types in all the primary tumors, in the cultures grown from them, and in the secondary in vivo tumors grown from the cultures. Many unmistakable stigmata of glia were conserved. Cloned cultures (derived from a single cell) were frozen and stored, and upon thawing resumed growth with their original histological appearance. Tumor lines from these cultured cloned strains showed much more constant growth rates and cell types; two stable lines were carried for many generations: a slow-growing astrocytoma and a faster growing glioblastoma. The distinctive neural protein called “S-100” was detected in soluble extracts of cultured cells from all five different primary tumors studied and the secondary tumors grown from them. It represented 0.2% to 0.4% of the soluble proteins extracted from the cultures, and was also present in some clonal strains and their derived tumors. One clonal strain after a few hundred generations continues to synthesize S-100. It is concluded that clonally derived cultures of gliomas histologically similar to those in man provide a stable and suitable model in rats for the study of human glia and gliomas.
Possible involvement of eicosanoids in the pharmacological action of bromelain. (1986)

Bromelain, a proteolytic enzyme extracted from pineapple plants, was investigated for its capacity to interfere with arachidonic acid metabolism, since prostaglandins and other eicosanoids are well-known to be involved in the pathogenesis of inflammatory diseases. Bromelain was tested for its ability to interfere with eicosanoids generation in vivo in two experimentally-induced inflammatory reactions in the rat. Also antiplatelet aggregation activity of bromelain was studied in ex vivo rat platelets. The results seem to indicate an interference of bromelain with arachidonic acid cascade, which, however, deserves further investigation to be better assessed.
LogTM: Log-based Transactional Memory (2006)

Transactional memory (TM) simplifies parallel programming by guaranteeing that transactions appear to execute atomically and in isolation. Implementing these properties includes providing data version management for the simultaneous storage of both new (visible if the transaction commits) and old (retained if the transaction aborts) values. Most (hardware) TM systems leave old values "in place" (the target memory address) and buffer new values elsewhere until commit. This makes aborts fast, but penalizes (the much more frequent) commits. In this paper, we present a new implementation of transactional memory, log-based transactional memory (LogTM), that makes commits fast by storing old values to a per-thread log in cacheable virtual memory and storing new values in place. LogTM makes two additional contributions. First, LogTM extends a MOESI directory protocol to enable both fast conflict detection on evicted blocks and fast commit (using lazy cleanup). Second, LogTM handles aborts in (library) software with little performance penalty. Evaluations running micro- and SPLASH-2 benchmarks on a 32-way multiprocessor support our decision to optimize for commit by showing that only 1-2% of transactions abort.
DNA Recognition Interfaces:  The Influence of Interfacial Design on the Efficiency and Kinetics of Hybridization (2005)

The effect of the surface chemistry of DNA recognition interfaces on DNA hybridization at a gold surface was investigated using both electrochemistry and the quartz crystal microbalance (QCM) technique. Different DNA recognition interfaces were prepared using a two-component self-assembled monolayer consisting of thiolated 20-mer probe single-stranded DNA (ss-DNA) containing either a 3‘-mercaptopropyl or a 3‘-mercaptohexyl linker group and an alcohol-terminated diluent layer with 2-, 6-, or 11-carbon length. The influence of the interfacial design on the hybridization efficiency, the affinity constant (Ka) describing hybridization, and the kinetics of hybridization was assessed. It was found that the further the DNA was above the surface defined by the diluent layer the higher the hybridization efficiency and Ka. The kinetics of DNA hybridization was assessed using both a QCM and an electrochemical approach to ascertain the influence of the interface on both the initial binding of target DNA to the surface and the formation of a complete duplex. These measurements showed that the length of the diluent layer has a large impact on the time taken to form a perfect duplex but no impact on the initial recognition of the target DNA by the immobilized probe DNA.