Bacterial Long Chain Fatty Acid Transport: Gateway to a Fatty Acid-responsive Signaling System (2004)

Exogenous long chain fatty acids (LCFAs) 1The abbreviations used are: LCFA, long chain fatty acid; ACSL, acyl-CoA synthetase; LCA-CoA, long chain acyl-CoA; LDAO, lauryldimethylamine N-oxide.1The abbreviations used are: LCFA, long chain fatty acid; ACSL, acyl-CoA synthetase; LCA-CoA, long chain acyl-CoA; LDAO, lauryldimethylamine N-oxide. influence a myriad of cellular processes including intracellular signaling and patterns of gene expression. Some cell types accumulate distinct classes of LCFAs whereas others accumulate or release fatty acids following some type of external stimulus (i.e. hormonal or nutritional cues). Given the energetic cost of fatty acid synthesis on one hand and (at least in the mammalian system) the necessity for obtaining essential fatty acids from the environment, the transport of LCFAs must necessarily represent a fundamental biological process. The biochemical mechanisms underpinning fatty acid transport involve specific proteins and enzymes, which act either directly at the membrane or indirectly at the level of downstream metabolism. Distinct membrane-bound and membrane-associated fatty acid transport proteins have been identified and characterized in a number of different systems including bacteria, yeast, and mammals (1Abumrad N. Harmon C. Ibrahimi A. J. Lipid Res. 1998; 39: 2309-2318Abstract Full Text Full Text PDF PubMed Google N. C. Ibrahimi A. PubMed Google PubMed Google J. PubMed Google PubMed Google A. A. 1998; PubMed Google Full Text PDF PubMed Google and biochemical of transport in the The of the transport and of which in in patterns of the the proteins for fatty acid and The of membrane-bound fatty acid transport membrane-associated long chain acyl-CoA and a long chain The fatty acid transport and downstream fatty a fundamental in which a number of of and in transport of LCFAs the cell of the transport the and the the The of long chain the the of the the which in the of in fatty acid and in 1998; PubMed Google and Lipid Res. PubMed Google The in the of and the the of the fatty acid transport and in Res. PubMed Google J. PubMed Google J. PubMed Google identified and of the of the fatty acid and distinct including Res. PubMed Google J. PubMed Google J. PubMed Google identified the gene in and at a of the fatty acid transport J. PubMed Google characterized the for the of fatty acids and in the of fatty acid transport for the transport in the membrane fatty acids from the membrane J. 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Some cell types accumulate distinct classes of LCFAs whereas others accumulate or release fatty acids following some type of external stimulus (i.e. hormonal or nutritional cues). Given the energetic cost of fatty acid synthesis on one hand and (at least in the mammalian system) the necessity for obtaining essential fatty acids from the environment, the transport of LCFAs must necessarily represent a fundamental biological process. The biochemical mechanisms underpinning fatty acid transport involve specific proteins and enzymes, which act either directly at the membrane or indirectly at the level of downstream metabolism. Distinct membrane-bound and membrane-associated fatty acid transport proteins have been identified and characterized in a number of different systems including bacteria, yeast, and mammals (1Abumrad N. Harmon C. Ibrahimi A. J. Lipid Res. 1998; 39: 2309-2318Abstract Full Text Full Text PDF PubMed Google N. C. Ibrahimi A. PubMed Google PubMed Google J. PubMed Google PubMed Google A. A. 1998; PubMed Google Full Text PDF PubMed Google The and biochemical of transport in the The of the transport and of which in in patterns of the the proteins for fatty acid and The of membrane-bound fatty acid transport membrane-associated long chain acyl-CoA and a long chain The fatty acid transport and downstream fatty a fundamental in which a number of of and in transport of LCFAs the cell of the transport the and the the The of long chain the the of the the which in the of in fatty acid and in 1998; PubMed Google and Lipid Res. PubMed Google The in the of and the the of the fatty acid transport and in Res. PubMed Google J. PubMed Google J. PubMed Google identified and of the of the fatty acid and distinct including Res. PubMed Google J. PubMed Google J. PubMed Google identified the gene in and at a of the fatty acid transport J. PubMed Google characterized the for the of fatty acids and in the of fatty acid transport for the transport in the membrane fatty acids from the membrane J. PubMed Google a and PubMed Google identified a type acyl-CoA fatty acids the gene in the of LCFAs and a the of the PubMed Google and A. PubMed Google identified the gene in the of a in the transport of the of the gene membrane-bound fatty acid the transport of LCFAs and in A. PubMed Google J. Full Text PDF PubMed Google J. Full Text PDF PubMed Google and of J. Full Text PDF PubMed Google in the membrane and for The of in the membrane and in the transport of fatty acids the in the J. PubMed Google Lipid Res. PubMed Google J. Full Text PDF PubMed Google PubMed Google PubMed Google J. PubMed Google PubMed Google the of the and the long chain acyl-CoA Lipid Res. PubMed Google J. Full Text PDF PubMed Google the of fatty acid transport and LCA-CoA, in the of long chain fatty and 1998; PubMed Google Lipid Res. 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