gebhart/patrepeval huggingface dataset:
Design of a low-power consumption wearable reflectance pulse oximetry for ubiquitous healthcare system (2008)

This paper describes the designation of a real-time, wearable reflectance pulse oximetry based on a wireless sensor network. In order to monitor human physiological signals continuously, wearable reflectance pulse oximetry is built in wrist form that could used to obtain oxygen saturation of a patient unobtrusively. The wearable reflectance pulse oximetry consists of reflectance probe, SpO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> module and wireless sensor node. The reflectance probe is designed to collaborate with LEDs with wavelengths of 660nm and 940nm. SpO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> module is designed to manage almost of all of the internal processing (e.g. analog signal processing, signal collection and calibration, etc). It is based on a low-power 8 bit ATmega128L microcontroller that operates in 3V. Low-power processing SpO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> module was integrated on wireless sensor node for wireless communication. The oxygen saturation collected from wireless sensor node was transmitted wirelessly to a base-station for storage and display purposes. This paper focused on the successful integration of all these components into wearable reflectance pulse oximetry and performed its ability to measure patient’ oxygen saturation for ubiquitous healthcare system.
Chromium Picolinate Toxicity (1998)

Chromium supplements may cause serious renal impairment when ingested in excess. Medication histories should include attention to the use of OTC nutritional supplements often regarded as harmless by the public and lay media.
NK314, a Topoisomerase II Inhibitor That Specifically Targets the α Isoform (2008)

Topoisomerase II (Top2) is a ubiquitous nuclear enzyme that relieves torsional stress in chromosomal DNA during various cellular processes. Agents that target Top2, involving etoposide, doxorubicin, and mitoxantrone, are among the most effective anticancer drugs used in the clinic. Mammalian cells possess two genetically distinct Top2 isoforms, both of which are the target of these agents. Top2alpha is essential for cell proliferation and is highly expressed in vigorously growing cells, whereas Top2beta is nonessential for growth and has recently been implicated in treatment-associated secondary malignancies, highlighting the validity of a Top2alpha-specific drug for future cancer treatment; however, no such agent has been hitherto reported. Here we show that NK314, a novel synthetic benzo[c]phenanthridine alkaloid, targets Top2alpha and not Top2beta in vivo. Unlike other Top2 inhibitors, NK314 induces Top2-DNA complexes and double-strand breaks (DSBs) in an alpha isoform-specific manner. Heterozygous disruption of the human TOP2alpha gene confers increased NK314 resistance, whereas TOP2beta homozygous knock-out cells display increased NK314 sensitivity, indicating that the alpha isoform is the cellular target. We further show that the absence of Top2beta does not alleviate NK314 hypersensitivity of cells deficient in non-homologous end-joining, a critical pathway for repairing Top2-mediated DSBs. Our results indicate that NK314 acts as a Top2alpha-specific poison in mammalian cells, with excellent potential as an efficacious and safe chemotherapeutic agent. We also suggest that a series of human knock-out cell lines are useful in assessing DNA damage and repair induced by potential topoisomerase-targeting agents.
Surface Micromachined Piezoelectric Resonant Beam Filters (2000)

Piezoelectric actuation and sensing of suspended single-beam microelectromechanical system (MEMS) resonant filters is demonstrated.
Effects of Nandrolone Therapy on Forearm Bone Mineral Content in Osteoporosis (1987)

Forearm bone mineral content (BMC) was measured sequentially on and off anabolic steroid therapy in 52 postmenopausal women with osteoporosis. The steroid used was nandrolone decanoate in a dose of 50 mg every two weeks by intramuscular injection. In 16 of the patients nandrolone was given first (for 6.2 ± 0.6 months) followed by a control period (6.1 ± 1.0 months) and in 36 there was an initial control period (9.5 ± 1.1 months) followed by nandrolone (for 5.8 ± 0.4 months). Any other therapy was continued unchanged during both treatment and control periods. There was a significant rise in BMC on nandrolone (p < 0.001) and a nonsignificant fall in BMC off nandrolone. The difference between the rates of change on and off nandrolone was highly significant (+53 vs. −7 mg/cm/year; p < 0.001).
Multiple metal-carbon bonds. 19. How niobium and tantalum complexes of the type M(CHCMe3)(PR3)2Cl3 can be modified to give olefin metathesis catalysts (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple metal-carbon bonds. 19. How niobium and tantalum complexes of the type M(CHCMe3)(PR3)2Cl3 can be modified to give olefin metathesis catalystsS. M. Rocklage, J. D. Fellmann, G. A. Rupprecht, L. W. Messerle, and R. R. SchrockCite this: J. Am. Chem. Soc. 1981, 103, 6, 1440–1447Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ja00396a025https://doi.org/10.1021/ja00396a025research-articleACS PublicationsRequest reuse permissionsArticle Views629Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Global analysis of large-scale chemical and biological experiments. (2002)

Research in the life sciences is increasingly dominated by high-throughput data collection methods that benefit from a global approach to data analysis. Recent innovations that facilitate such comprehensive analyses are highlighted. Several developments enable the study of the relationships between newly derived experimental information, such as biological activity in chemical screens or gene expression studies, and prior information, such as physical descriptors for small molecules or functional annotation for genes. The way in which global analyses can be applied to both chemical screens and transcription profiling experiments using a set of common machine learning tools is discussed.
FPA144-001: A first in human study of FPA 144, an ADCC-enhanced, FGFR2b isoform-selective monoclonal antibody in patients with advanced solid tumors. (2016)

140 Background: FPA144 is a humanized monoclonal IgG1 antibody directed against the 2b Isoform of thefibroblast growth factor receptor (FGFR2b) that has been glycoengineered to enhance ADCC. Amplification of FGFR2 is found in a number of tumors, including 3 – 9% of gastric cancer, and is associated with poor prognosis. FPA144-001 is a phase 1 study in two parts: Part 1 will evaluate the safety and pharmacokinetics (PK) of FPA144 in patients with solid tumors; Part 2 will evaluate efficacy in gastric cancer patients whose tumors overexpress FGFR2b, as determined by a proprietary test. Here we present early safety and PK results from solid tumor patients treated with FPA144. Methods: A standard 3+3 design was used to assess safety, tolerability and PK of escalating doses of FPA144 in patients with advanced solid tumors (Part 1A) or recurrent/metastatic gastric cancer (Part 1B). Tumor testing for FGFR2gene amplification or FGFR2b overexpression was conducted centrally by a proprietary assay consisting of both FISH and IHC. Results: At the time of data analysis, enrollment of FPA144-001 through the 6mg/kg q2w cohort had been completed. In Part 1A, 13 patients with 8 different tumor types have been enrolled. Patients have been treated for an average of 4 cycles (range 1 – 10, median 2) or 101 days (range 28 – 287, median 43). Nine patients have discontinued the study for progressive disease or lack of clinical benefit; all others continue on study treatment. No dose-limiting toxicities have been observed, and no patients have withdrawn due to an adverse drug reaction. Upper respiratory infection, alopecia and fatigue are the AEs reported in more than one patient; one SAE of dyspnea and pyrexia not related to drug has been reported. PK analysis demonstrates non-linear clearance in doses up to 3mg/kg, likely due to receptor-mediated clearance. Conclusions: FPA144 is a glycoengineered monoclonal antibody directed against FGFR2b that is being developed for the treatment of patients with tumors that overexpress FGFR2b. FPA144 has been safely administered at doses up to 6mg/kg q2w; dose escalation continues. Updated safety, PK and anti-tumor activity will be presented. Clinical trial information: NCT02318329.
Nucleotide Variation at the CHALCONE ISOMERASE Locus in Arabidopsis thaliana (2000)

An approximately 1.9-kb region encompassing the CHI gene, which encodes chalcone isomerase, was sequenced in 24 worldwide ecotypes of Arabidopsis thaliana (L.) Heynh. and in 1 ecotype of A. lyrata ssp. petraea. There was no evidence for dimorphism at the CHI region. A minimum of three recombination events was inferred in the history of the sampled ecotypes of the highly selfing A. thaliana. The estimated nucleotide diversity theta(TOTAL) = 0.004, theta(SIL) = 0. 005 was on the lower part of the range of the corresponding estimates for other gene regions. The skewness of the frequency spectrum toward an excess of low-frequency polymorphisms, together with the bell-shaped distribution of pairwise nucleotide differences at CHI, suggests that A. thaliana has recently experienced a rapid population growth. Although this pattern could also be explained by a recent selective sweep at the studied region, results from the other studied loci and from an AFLP survey seem to support the expansion hypothesis. Comparison of silent polymorphism and divergence at the CHI region and at the Adh1 and ChiA revealed in some cases a significant deviation of the direct relationship predicted by the neutral theory, which would be compatible with balancing selection acting at the latter regions.
Novel 5′ Exon of Scavenger Receptor CD36 Is Expressed in Cultured Human Vascular Smooth Muscle Cells and Atherosclerotic Plaques (2002)

CD36, a member of the scavenger receptor family, is centrally involved in the uptake of oxidized low density lipoproteins (oxLDLs) from the bloodstream. During the atherosclerotic process, the lipid cargo of oxLDL accumulates in macrophages and smooth muscle cells (SMCs), inducing their pathological conversion to foam cells. Increased expression of CD36 occurs in human atherosclerotic lesions, and CD36 knockout mice show reduced uptake of modified LDLs and reduced atherosclerosis. Here, we describe a novel exon 1b and extended CD36 promoter in human SMCs. Exon 1b is specifically transcribed in activated aortic SMCs and mainly expressed in atherosclerotic plaques. Thus, switching to exon 1b transcription may be an important step for the activation of SMCs and their conversion to foam cells. Using an antisense oligonucleotide to exon 1b, we inhibit CD36 translation and highly reduce oxLDL uptake. The antisense to exon 1b does not affect CD36 in cell lines not expressing the new exon. The possibility of a novel antiatherosclerotic therapy and the use of exon 1b as a marker of atherosclerosis are discussed.
Long, Processive Enzymatic DNA Synthesis Using 100% Dye-Labeled Terminal Phosphate-Linked Nucleotides (2008)

We demonstrate the efficient synthesis of DNA with complete replacement of the four deoxyribonucleoside triphosphate (dNTP) substrates with nucleotides carrying fluorescent labels. A different, spectrally separable fluorescent dye suitable for single molecule fluorescence detection was conjugated to each of the four dNTPs via linkage to the terminal phosphate. Using these modified nucleotides, DNA synthesis by phi 29 DNA polymerase was observed to be processive for products thousands of bases in length, with labeled nucleotide affinities and DNA polymerization rates approaching unmodified dNTP levels. Results presented here show the compatibility of these nucleotides for single-molecule, real-time DNA sequencing applications.
Decoupling Bulk Thermodynamics and Wetting Characteristics of Block Copolymer Thin Films (2011)

The consequences on certain physical properties of controlled levels of epoxidation of the poly(isoprene) blocks in poly(styrene-<i>b</i>-isoprene) (PS-PI) diblock copolymers and poly(isoprene) (hPI) homopolymers have been studied, where the products after epoxidation are denoted PS-PIxn and hPIxn, respectively. The effective interaction parameters χ<sub>eff</sub> between the PS and the PIxn blocks were estimated by applying mean-field theory to the lamellar periodicities identified by small-angle X-ray scattering and to the order-to-disorder transition temperatures determined by dynamic mechanical spectroscopy. These results were fit to a binary segment-segment interaction parameter model indicating a nonlinear change in χ<sub>eff</sub> with percent epoxidation. In contrast, contact angle measurement on hPIxn and lamellar orientations of thin-film PS-PIxn suggest that the surface energy of PIxn increases linearly with epoxidation. This decoupling of bulk and thin-film thermodynamic behaviors is attributed to the different roles that a random copolymer architecture plays in establishing three-dimensional order versus wetting at a two-dimensional surface.
Purification and N-Terminal Amino Acid Sequence of Two Birch Pollen Isoallergens (Bet v I and Bet v II) (1990)

The major allergen of birch pollen BV45 (Bet v I) was previously isolated by molecular weight exclusion chromatography and eluted in the molecular weight region of 15–29 KD. Further purification of this fraction on an SP-Trisacryl M cation exchange matrix allowed 6 peaks of which the 4th (BV4A4) and 6th (BV4A6) included two dominant IgE-binding birch pollen isoallergens designated Bet v I and Bet v II. Final purification, using the ‘Applied Biosystems’ Peptide Micro Separation System, revealed two sharp peaks with a high degree of homogeneity. This was ascertained by automatic N-terminal amino acid (AA) sequence analyses which showed high average repetitive yields of the phenyl-thiohydantoin (PTH) AAs of the isoallergens sequenced. N-terminal AA analyses of the two fractions allowed 51 cleavages with correct identifications of PTH AAs for 3 replicates. The sequence data of the two isoallergens showed large homologies with the hazel pollen allergen, Cor a I, the birch pollen allergen, Ag 23, and the translated cDNA sequence derived from cloning birch pollen allergen genes. The sequence homologies support that &lt;i&gt;Betula verrucosa&lt;/i&gt; allergens were derived from a gene family expressing several isologous allergens, 2 of which with 13 variable residues in a segment of 51 AAs. The antigenicity of the two fractions, Bet v I and Bet v II, was demonstrated by fused rocket immunoelectrophoresis (FRIE) and by crossed immunoelectrophoresis (CIE) giving single symmetrical antigenic precipitation. The specific IgE-binding capacity of the two isoallergens was supported by: (a) immunoautoradiography of the plates provided from FRIE; (b) specific IgE-binding inhibition in radioallergosorbent test (RAST) for fraction BV4A, and (c) similarly high RAST inhibition for the individual isoallergens. The in vivo allergenic activity was clearly shown by skin prick and nasal provocation tests. In conclusion, two isoallergens from birch pollen with proximate pi values (5.2 and 5.5) were isolated for the first time and the N-terminal sequence characterized.
Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group. (1997)

Large-scale genotyping is required to generate dense identity-by-descent maps to map genes for human complex disease. In some studies the number of genotypes needed can approach or even exceed 1 million. Generally, linkage and linkage disequilibrium analyses depend on clear allele identification and subsequent allele frequency estimation. Accurate grouping or categorization of each allele in the sample (allele calling or binning) is therefore an absolute requirement. Hence, a genotyping system that can reliably achieve this is necessary. In the case of affected sib-pair analysis without parents, the need for accurate allele calling is even more critical. We describe methods that permit precise sizing of alleles across multiple gels using the fluorescence-based, Applied Biosystems (ABI) genotyping technology and discuss ways to reduce genotyping error rates. Using database utilities, we show how to minimize intergel allele size variation, to combine data effectively from different models of ABI sequencing machines, and automatically bin alleles. The final data can then be converted into a format ready for analysis by statistical genetic packages such as MENDEL.
Regression Models for Behavioral Power Estimation (1998)

Behavioral power estimation is required to help the designer in making important architectural choices. In this work we propose an accurate and general behavioral power modeling approach especially suited for synthesis-based design ows making use of
2011地平线报告：教育学习领域的新型技术（摘要） (2011)

由“新媒体联盟”持续推出的“地平线系列报告”是一个综合的研究报告。2002年建立以来，它辨别并描述未来五年可能对全球多个地区产生重大影响的新兴技术。2011年的“地平线报告”主要调查了对教育、学习和创造性信息查询有潜在影响或用途的新兴技术。
Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility after only 15 Minutes of Antibiotic Exposure (2016)

Rapid antimicrobial susceptibility testing (AST) would decrease misuse and overuse of antibiotics. The "holy grail" of AST is a phenotype-based test that can be performed within a doctor visit. Such a test requires the ability to determine a pathogen's susceptibility after only a short antibiotic exposure. Herein, digital PCR (dPCR) was employed to test whether measuring DNA replication of the target pathogen through digital single-molecule counting would shorten the required time of antibiotic exposure. Partitioning bacterial chromosomal DNA into many small volumes during dPCR enabled AST results after short exposure times by 1) precise quantification and 2) a measurement of how antibiotics affect the states of macromolecular assembly of bacterial chromosomes. This digital AST (dAST) determined susceptibility of clinical isolates from urinary tract infections (UTIs) after 15 min of exposure for all four antibiotic classes relevant to UTIs. This work lays the foundation to develop a rapid, point-of-care AST and strengthen global antibiotic stewardship.
Direct, Electronic MicroRNA Detection for the Rapid Determination of Differential Expression Profiles (2009)

In the time it takes for lunch: An electronic chip featuring nanostructured microelectrodes (NMEs) enables the analysis of microRNA expression profiles in just 30 min in small RNA samples without enzymatic amplification or sequence labeling. The multiplexed chip detects the hybridization of microRNA targets to NME surfaces and provides large electrocatalytic gain through the use of an ultrasensitive redox reporter system (see picture).
Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials (2012)

Vasopressin use in vasodilatory shock is safe, associated with reduced mortality, and facilitates weaning of catecholamines. In patients with septic shock, use of vasopressin compared with norepinephrine may also decrease mortality.
An architecture for concurrent execution of secure environments in clouds (2013)

We propose an architecture that enables the creation and management of multiple, concurrent secure execution environments on multi-core systems. Our architecture is suitable for use in cloud settings where each user may require an independent secure environment within which he can run his sensitive applications. Our solution effectively scales architectures like Intel TXT which, both on single- and multi-core platforms, support the creation of only one secure environment. Unlike existing solutions that require significant hypervisor participation, our architecture relies on light-weight processor extensions and a novel hardware-based virtualized TPM that supports multiple, concurrent dynamic root of trust requests from different VMs. This, together with the virtualization extensions in modern processors, allows the use of a disengaged hypervisor that is only responsible for VM management (i.e., creation, deletion, startup, shutdown) and is not involved in the creation or management of secure execution environments. Such disengagement not only reduces hypervisor complexity but also its interaction with guest VMs and hence, the risk of system compromise. We show that our architecture provides guest applications independent secure environments within which they can concurrently execute, and protects them against other compromised system components including malicious VMs and peripherals. We also demonstrate the feasibility of realizing our architecture by emulating and testing it using QEMU.
A template matcher for robust NL interpretation (1991)

In this paper, we describe the Template Matcher, a system built at SRI to provide robust natural-language interpretation in the Air Travel Information System (ATIS) domain.The system appears to be robust to both speech recognition errors and unanticipated or difficult locutions used by speakers.We explain the motivation for the Template Matcher, describe in general terms how it works in comparison with similar systems, and examine its performance.We discuss some limitations of this approach, and sketch a plan for integrating the Template Matcher with an analytic parser, which we believe will combine the advantages of both.
[Expression of USP9X in Non-small Cell Lung Cancer and Its Clinical Significance]. (2015)

Up-regulation of USP9X plays an important role in the invasion and progression of NSCLC and could be considered as a prognostic predictor for NSCLC.