gebhart/patrepeval huggingface dataset:
Fundamentals of Stereolithography (2018)

It has only been a little over four years since the introduction&#13;\nof the first StereoLithography system, the SLA-1. From early 1988&#13;\nuntil J.une 1992 over 300 SLA-1, SLA-250, SLA-190 and SLA-500 units have&#13;\nbeen sold by 3D Systems. These machines, currently operating in 20&#13;\ncountries on five continents, amount to about 90 percent of all the&#13;\nrapid prototyping systems now in use.
The 1.9 Å resolution structure ofMycobacterium tuberculosis1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target (2006)

1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate, as the second step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway found in many bacteria and plants. The end product, isopentenyl diphosphate, is the precursor of various isoprenoids vital to all living organisms. The pathway is not found in humans; the mevalonate pathway is instead used for the formation of isopentenyl diphosphate. This difference, combined with its essentiality, makes the reductoisomerase an excellent drug target in a number of pathogenic organisms. The structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Mycobacterium tuberculosis (Rv2870c) was solved by molecular replacement and refined to a resolution of 1.9 A. The enzyme exhibited an estimated kcat of 5.3 s-1 and Km and kcat/Km values of 7.2 microM and 7.4x10(5) M-1 s-1 for NADPH and 340 microM and 1.6x10(4) M-1 s-1 for 1-deoxy-D-xylulose 5-phosphate. In the structure, a sulfate is bound at the expected site of the phosphate moiety of the sugar substrate. The M. tuberculosis enzyme displays a similar fold to the previously published structures from Escherichia coli and Zymomonas mobilis. Comparisons offer suggestions for the design of specific drugs. Furthermore, the new structure represents an intermediate conformation between the open apo form and the closed holo form observed previously, giving insights into the conformational changes associated with catalysis.
CRABS CLAW, a gene that regulates carpel and nectary development in Arabidopsis, encodes a novel protein with zinc finger and helix-loop-helix domains (1999)

Studies of plants with mutations in the CRABS CLAW gene indicate that it is involved in suppressing early radial growth of the gynoecium and in promoting its later elongation. It is also required for the initiation of nectary development. To gain further insight, the gene was cloned by chromosome walking. CRABS CLAW encodes a putative transcription factor containing a zinc finger and a helix-loop-helix domain. The latter resembles the first two helices of the HMG box, known to bind DNA. At least five other genes of Arabidopsis carry the same combination of domains, and we have named them the yabby family. The new helix-loop-helix domain itself we call the yabby domain. Consistent with the mutant phenotype, CRABS CLAW expression is mostly limited to carpels and nectaries. It is expressed in gynoecial primordia from their inception, firstly in lateral sectors where it may inhibit radial growth, and later in the epidermis and in four internal strips. The internal expression may be sufficient to support longitudinal growth, as carpels are longer in a crabs claw promoter mutant where expression is now confined to these regions. The patterns of expression of CRABS CLAW in ectopic carpels of floral homeotic mutants suggest that it is negatively regulated by the A and B organ identity functions, but largely independent of C function. CRABS CLAW expression occurs in nectaries throughout their growth and maturation. It is also expressed in their presumptive anlagen so it may specify cells that will later develop as nectaries. Nectaries arise from the floral receptacle at normal positions in all A, B and C organ identity mutants examined, and CRABS CLAW is always expressed within them. Thus CRABS CLAW expression is regulated independently in carpels and nectaries.
Identification and Cloning of Neuroblastoma-Specific and Nerve Tissue-Specific Genes through Compiled Expression Profiles (1996)

An expression profile of active genes in a human neuroblastoma cell line CHP134 was obtained by collecting 1222 partial sequences from a 3'-directed cDNA library representing a non-biased mRNA population. By comparing this expression profile with the compiled profiles of multiple tissues, several novel gene transcripts that appeared only in the profile of the neuroblastoma cell line were identified. Further analyses by Northern blotting revealed two specific cDNA clones that are expressed in most of the human neuroblastomas examined, and three that are in some of the human neuroblastoma cell lines as well as in the adult human brain. Full-size cDNAs were cloned using these five partial cDNA sequences as probes and sequenced. A database search revealed that they are all novel and unique sequences: one sharing some amino acid sequence similarities with a cytoskeletal protein, two clones likely to be transcriptional factors, a clone that has characteristic potassium channel properties, and a clone that is non-homologous to any one of the known proteins. Thus, we argue that the collection of 3'-directed cDNA sequences in combination with the compiled expression profiles of active genes in multiple tissues is a powerful tool for discovering novel genes that are specifically expressed in a given cell or tissue, in this case neuroblastomas and/or nerve tissue.
Single-channel blind equalization for GSM cellular systems (1998)

This paper focuses on the study of blind equalization global system for mobile communications (GSM) systems using a single antenna. In order to utilize the well-known linear system model in conventional studies of blind equalization, an equivalent baseband quadrature amplitude modulation (QAM) approximation is used for the nonlinear GMSK signal in GSM systems. Since the GMSK signal in GSM has very little excess bandwidth to warrant oversampling, a derotation scheme is developed to create two subchannels for each received GMSK signal sampled at the baud rate. Linear approximation of the GMSK signal makes the traditional QAM blind equalization system model applicable for GSM. Derotation induces channel diversity without an additional antenna and reduces the number of necessary radio frequency (RF) receivers (sensors) without increasing hardware or computational costs. Several second-order statistical and higher order statistical methods of blind equalization are adopted for GSM signals.
The βγ Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Proteins (2002)

A yeast two-hybrid approach was used to discern possible new effectors for the betagamma subunit of heterotrimeric G proteins. Three of the clones isolated are structurally similar to Gbeta, each exhibiting the WD40 repeat motif. Two of these proteins, the receptor for activated C kinase 1 (RACK1) and the dynein intermediate chain, co-immunoprecipitate with Gbetagamma using an anti-Gbeta antibody. The third protein, AAH20044, has no known function; however, sequence analysis indicates that it is a WD40 repeat protein. Further investigation with RACK1 shows that it not only interacts with Gbeta(1)gamma(1) but also unexpectedly with the transducin heterotrimer Galpha(t)beta(1)gamma(1). Galpha(t) alone does not interact, but it must contribute to the interaction because the apparent EC(50) value of RACK1 for Galpha(t)beta(1)gamma(1) is 3-fold greater than that for Gbeta(1)gamma(1) (0.1 versus 0.3 microm). RACK1 is a scaffold that interacts with several proteins, among which are activated betaIIPKC and dynamin-1 (1). betaIIPKC and dynamin-1 compete with Gbeta(1)gamma(1) and Galpha(t)beta(1)gamma(1) for interaction with RACK1. These findings have several implications: 1) that WD40 repeat proteins may interact with each other; 2) that Gbetagamma interacts differently with RACK1 than with its other known effectors; and/or 3) that the G protein-RACK1 complex may constitute a signaling scaffold important for intracellular responses.
Efficient Estimation of Word Representations in Vector Space (2013)

We propose two novel model architectures for computing continuous vector representations of words from very large data sets. The quality of these representations is measured in a word similarity task, and the results are compared to the previously best performing techniques based on different types of neural networks. We observe large improvements in accuracy at much lower computational cost, i.e. it takes less than a day to learn high quality word vectors from a 1.6 billion words data set. Furthermore, we show that these vectors provide state-of-the-art performance on our test set for measuring syntactic and semantic word similarities.
A low-overhead coherence solution for multiprocessors with private cache memories (1998)

Article Free AccessA low-overhead coherence solution for multiprocessors with private cache memories Share on Authors: Mark S. Papamarcos Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, IL Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, ILView Profile , Janak H. Patel Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, IL Coordinated Science Laboratory, University of Illinois, 1101 W. Springfield, Urbana, ILView Profile Authors Info & Claims ISCA '98: 25 years of the international symposia on Computer architecture (selected papers)August 1998 Pages 284–290https://doi.org/10.1145/285930.285987Online:01 August 1998Publication History 11citation583DownloadsMetricsTotal Citations11Total Downloads583Last 12 Months11Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Vacuum-assisted closure in the paediatric patient with post-cardiotomy mediastinitis (2002)

Mediastinitis has a high mortality and is a major cause for concern in the neonatal cardiac surgical population. Vacuum-Assisted Closure (V.A.C.) is a newly established technique for expediting healing in the management of wounds resistant to established treatments; this includes the treatment of post-cardiotomy mediastinitis in the adult cardiac surgical patient. We describe the previously unreported use of the V.A.C. device for the successful treatment of post-cardiotomy mediastinitis in an infant. The device also improved the mechanics of respiration. We discuss potential risks and benefits of V.A.C. and suggest guidelines for its use.
SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis (1998)

In Staphylococcus epidermidis and Staphylococcus aureus, a number of cell wall- and cytoplasmic membrane-associated lipoproteins are induced in response to iron starvation. To gain insights into the molecular basis of iron-dependent gene regulation in the staphylococci, we sequenced the DNA upstream of the 3-kb S. epidermidis sitABC operon, which Northern blot analysis indicates is transcriptionally regulated by the growth medium iron content. We identified two DNA sequences which are homologous to elements of the Corynebacterium diphtheriae DtxR regulon, which controls, in response to iron stress, for example, production of diphtheria toxin, siderophore, and a heme oxygenase. Upstream of the sitABC operon and divergently transcribed lies a 645-bp open reading frame (ORF), which codes for a polypeptide of approximately 25 kDa with homology to the DtxR family of metal-dependent repressor proteins. This ORF has been designated SirR (staphylococcal iron regulator repressor). Within the sitABC promoter/operator region, we also located a region of dyad symmetry overlapping the transcriptional start of sitABC which shows high homology to the DtxR operator consensus sequence, suggesting that this region, termed the Sir box, is the SirR-binding site. The SirR protein was overexpressed, purified, and used in DNA mobility shift assays; SirR retarded the migration of a synthetic oligonucleotide based on the Sir box in a metal (Fe2+ or Mn2+)-dependent manner, providing confirmatory evidence that this motif is the SirR-binding site. Furthermore, Southern blot analysis of staphylococcal chromosomal DNA with the synthetic Sir box as a probe confirmed that there are at least five Sir boxes in the S. epidermidis genome and at least three in the genome of S. aureus, suggesting that SirR controls the expression of multiple target genes. Using a monospecific polyclonal antibody raised against SirR to probe Western blots of whole-cell lysates of S. aureus, S. carnosus, S. epidermidis, S. hominis, S. cohnii, S. lugdunensis, and S. haemolyticus, we identified an approximately 25-kDa cross-reactive protein in each of the staphylococcal species examined. Taken together, these data suggest that SirR functions as a divalent metal cation-dependent transcriptional repressor which is widespread among the staphylococci.
Detection of dsRNA in Grapevines Showing Symptoms of Rupestris Stem Pitting Disease and the Variabilities Encountered (1991)

Rupestris stem pitting (rSP), a graft-transmissible grapevine disease, can be identified only by its reaction (pitted wood) on inoculated Vitis rupestris ‘St. George.’ DsRNA was extracted from grapevines from California and Canada that indexed positive for rSP on St. George. Two distinct dsRNA species (B and C) (Mr = 5.3 × 106 and 4.4 × 106, respectively) were detected from the stem tissue of rSP-positive samples. Although similar dsRNA species (B and C) were detected in extracts of grapevines from New York, the association of dsRNA B and C with rSP in New York samples was not consistent. Also, eight different dsRNAs, known to be associated with the powdery mildew fungus, Uncinula necator, were detected in leaves of New York samples. In New York, the dsRNAs were not observed in leaves or stem samples collected from June through late August during the 1988 and 1989 growing seasons, suggesting that dsRNA detection in the grape tissue is variable throughout the season. We suggest that dsRNA species B and C are associated with rSP disease. The inconsistent results with New York samples are discussed.
Periodic pacing an in vitro epileptic focus (1995)

1. The effects of frequency of orthodromic and antidromic stimulation of CA3 on formation of electrographic seizurelike discharges in CA1 was studied in the high potassium hippocampal slice. 2. Within the range of stimulation of CA3 used, 0.1-10.0 Hz, a narrow range was identified between 1.0 and 1.3 Hz, where the tonic phase of seizure generation in CA1 was suppressed. This suppression was observed for both Schaffer collateral and mossy fiber stimulation.
Cancer as a Proinflammatory Environment: Metastasis and Cachexia (2015)

The development of the syndrome of cancer cachexia and that of metastasis are related with a poor prognostic for cancer patients. They are considered multifactorial processes associated with a proinflammatory environment, to which tumour microenvironment and other tissues from the tumour bearing individuals contribute. The aim of the present review is to address the role of ghrelin, myostatin, leptin, HIF, IL-6, TNF-α, and ANGPTL-4 in the regulation of energy balance, tumour development, and tumoural cell invasion. Hypoxia induced factor plays a prominent role in tumour macro- and microenvironment, by modulating the release of proinflammatory cytokines.
To link or not to link (1992)

Little is known about Hypertext writing style. This study examines the effects of link quantity and quality on usability. Our chosen domain is technical documentation which has a very regular writing style and organization. We compare two Hypertext Networks: one network has intuitively created links and the other is an algorithmic enhancement of it. The enhanced network has the same number of destination links, but more total link-anchors.Twelve subjects (six for each system) were asked to answer a set of eleven questions by navigating through the networks. We were interested in investigating three issues: efficiency (how many nodes need to be visited), speed (how much time is required) and accuracy (what is the error rate).Results showed that the lightly linked network required users to visit significantly more nodes to answer a question than the heavily linked equivalent. Heavy linking enabled users to find the answers to questions more quickly, but not significantly so. There was little difference in the error rate.
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases (1997)

Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of macrolide antibiotics, have recently been recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases (V-ATPases) and ATPases with phosphorylated states (P-ATPases) in animal and plant cells as well as in yeast, fungi and bacteria. The following review will give an account of the classification and function of these antibiotics.
A New pH-Switchable Dimannosyl[c2]Daisy Chain Molecular Machine (2008)

The preparation of a dimannosyl[c2]daisy chain molecular machine containing an ammonium and a triazolium station is described. The both stretched and contracted states of the molecular machine can be obtained by variation of the pH, thus localizing the mannosyl stoppers closer or farther away.
Functional P-gp expression in multiple myeloma patients at primary diagnosis and relapse or progressive disease. (1997)

In this study, 25 multiple myeloma (MM) patients at primary diagnosis and 18 MM patients at relapse or progressive disease (PD) were examined in order to investigate the incidence of P-glycoprotein (P-gp) expression at initial diagnosis and relapse or PD. Furthermore, P-gp expression in relation to VAD regimen response was determined. P-gp expression in the myeloma cells was determined using monoclonal antibody 4E3.16 and the rhodamine 123 functional test. The percentage of patients with P-gp overexpression at primary diagnosis ranged between 0 and 41% in the literature vs 32% in our study. The percentage of P-gp positive patients at relapse or PD ranged between 29 and 59% in the literature vs 33% in this analysis. All P-gp positive patients had a functional P-gp, ie a pumping P-gp. A significant difference concerning response (50 vs 58.3%) to VAD treatment and median survival (10 vs 12.5 months) between P-gp positive and P-gp negative patients could not be determined. Six of 12 P-gp negative MM patients at relapse or PD developed after VAD therapy a relapse combined with P-gp overexpression. These results do not confirm the suggestions that P-gp overexpression influences response to VAD treatment. However, the results described in the literature and our own emphasize the need for careful accompanying research programmes aimed at detecting the complexity of chemotherapy resistance in the light of developing a risk-adapting therapy for MM patients.
Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts (1995)

Growth of Shigella spp. in the presence of the bile salt deoxycholate or chenodeoxycholate enhanced the bacterial invasion of HeLa cells. Growth in the presence of other structurally similar bile salts or detergents had little or no effect. Deoxycholate-enhanced invasion was not observed when bacteria were exposed to deoxycholate at low temperatures or when chloramphenicol was added to the growth medium, indicating that bacterial growth and protein synthesis are required. Increased invasion is associated with the presence of an intact Shigella virulence plasmid and is correlated with increased secretion of a set of proteins, including the Ipa proteins, to the outer membrane and into the growth medium. The increased invasion induced by the bile salts appears to be due to increased adherence. The enhanced adherence was specific to Shigella spp., since the enteroinvasive Escherichia coli strains tested did not exhibit the effect in response to growth in bile salts.
Human herpesviruses: a consideration of the latent state (1989)

Rapport et considerations sur les donnees etablies ces 10 dernieres annees (149 references) concernant l'etat de latence de 6 Herpesvirus humains, en particulier l'Herpex Simplex virus de type 1 (HSV-1) et le virus Epstein Barr (EBV). Recapitulation des differents evenements et mecanismes impliques dans l'etablissement, la maintenance et reactivation de cet etat de latence
Selling Spectrum Rights (1994)

The design of the FCC spectrum-license auction is a case study in the application of economic theory. Auction theory helped address policy questions such as: Should an open auction or a sealed-bid auction be used? Should the licenses be auctioned sequentially or simultaneously? Should the government allow bids for combinations of licenses, or should it accept only single-license bids? How should the auction be structured to promote the interests of minority-owned and other designated firms? Should the government impose royalties or reserve prices? How much should the bidders be informed about their competition?
PILGRIM: A location broker and mobility-aware recommendation system (2004)

Mobile computing adds a mostly unexplored dimension to data mining: user's position is a relevant piece of information, and recommendation systems, selecting and ranking links of interest to the user, have the opportunity to take location into account. In this paper a mobility-aware recommendation system that considers the location of the user to filter recommended links is proposed. To avoid the potential problems and costs of insertion by hand, a new middleware layer, the location broker, maintains a historic database of locations and corresponding links used in the past and develops models relating resources to their spatial usage pattern. These models are used to calculate a preference metric when the current user is asking for resources of interest. Mobility scenarios are described and analyzed in terms of possible user requirements. The features of the PILGRIM mobile recommendation system are outlined together with a preliminary experimental evaluation of different metrics.
High resolution maps from wide angle sonar (2005)

We describe the use of multiple wide-angle sonar range measurements to map the surroundings of an autonomous mobile robot. A sonar range reading provides information concerning empty and occupied volumes in a cone (subtending 30 degrees in our case) in front of the sensor. The reading is modelled as probability profiles projected onto a rasterized map, where somewhere occupied and everywhere empty areas are represented. Range measurements from multiple points of view (taken from multiple sensors on the robot, and from the same sensors after robot moves) are systematically integrated in the map. Overlapping empty volumes re-inforce each other, and serve to condense the range of occupied volumes. The map definition improves as more readings are added. The final map shows regions probably occupied, probably unoccupied, and unknown areas. The method deals effectively with clutter, and can be used for motion planning and for extended landmark recognition. This system has been tested on the Neptune mobile robot at CMU.