gebhart/patrepeval huggingface dataset:
Exploring intelligent peripheral configurations (2002)

The intelligent peripheral (IP) is one of the most important components of the advanced intelligent network (AIN) infrastructure for implementing new network based services that cannot be easily provided by the traditional switching elements. Bellcore has developed requirements for the IP interface in document TA-NWT-001129; this document recommends that all the IP-SCP communication be routed through the service switching point (SSP). This IP interface recommendation is unnecessarily expensive in terms of SSP central processing unit (CPU) resources as every message exchanged between the SCP and the IP is translated by the SSP. Furthermore, the Bellcore recommended interface will not be available for a few more years from the major switching vendors. This may delay the deployment of AIN services leading the customers to seek other competing technologies. In GTEs AIN testbed we have implemented direct control of the IP from the service control point (SCP) as an alternative to Bellcore IP interface, and in our experience, this interface definitely proves a worthy alternative. The paper gives an overview of alternative TP configurations and how they are used in services such as UPT registration and out-call. A brief qualitative comparison of the Bellcore recommended architecture and the direct IP-SCP interface and a hybrid interface is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Iodide-Based Atomic Layer Deposition of ZrO2: Aspects of Phase Stability and Dielectric Properties (2002)

This study is an investigation into the influence of temperature, substrate, and thickness on the properties of ZrO2 thin films grown by atomic layer deposition (ALD). ZrI4 and H2O2 were used as source materials, and films deposited at temperatures between 250 °C and 500 °C consisted of mixed tetragonal and monoclinic ZrO2. The phase content and electrical properties of films of 3–30 nm thickness were studied for different temperatures and substrates. The films crystallized at smaller thicknesses on the Pt/Ti/SiO2/Si (denoted Pt in the following text) substrate than on polycrystalline Si (poly-Si) and MgO(001). It was also found that the film thickness had a stronger effect on the dielectric constant than either the growth temperature or the substrate.
Mevinolin Plus Colestipol in Therapy for Severe Heterozygous Familial Hypercholesterolemia (1984)

Twelve patients with severe heterozygous familial hypercholesterolemia, in whom other hypolipidemic drug therapy had failed to reduce serum cholesterol levels to less than 300 mg/dL, were sequentially treated with mevinolin (a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis) and colestipol. In ten patients receiving 80 mg/d of mevinolin, plasma cholesterol concentrations decreased 33%, from 487 +/- 27 (SE) mg/dL to 326 +/- 16 mg/dL. Additional therapy with colestipol resulted in a further 18% decrease, to 269 +/- 13 mg/dL. Concentrations of low density lipoprotein (LDL) cholesterol decreased in parallel (54% decrease on combined drug therapy). Plasma concentrations of high density lipoprotein cholesterol did not change significantly, but the LDL:HDL ratio decreased from 8.2 in patients on diet only to 3.8 in patients treated with mevinolin and colestipol. In seven patients treated with 40 mg/d of mevinolin, concentrations of LDL cholesterol decreased by 33%; combined therapy resulted in a further 20% decrease (46% reduction from the level achieved with diet only). No consistent side effects have been noted in up to 24 months of therapy. Combined therapy with mevinolin and colestipol promises to be effective for heterozygous familial hypercholesterolemia.
Carbohydrate‐based crosslinking agents: Potential use in hydrogels (2011)

A bis(methacrylamido) derivative of glucose has been used as a crosslinking agent for PHEMA sponges formed by polymerization-induced phase separation.
Adaptive field/frame selection for high-compression coding (2003)

In practice, interlaced video sequences are typically coded with either a frame-only or field-only structure, irrespective of the content. However, coding in this way will not provide the best coding efficiency. This paper proposes an adaptive picture-level field/frame coding scheme with corresponding rate control. First, a two-pass field/frame decision scheme is proposed. In this scheme, we formulate the field/frame decision as a constrained optimization problem. The actual rate and distortion data are collected and the optimal picture-level coding decision is determined based on this data. An effective rate control for the proposed two-pass algorithm is also presented. However, since the complexity of the two-pass scheme is relatively large since motion estimation must be performed for both the frame-based picture and the field-based picture, we also propose a one-pass field/frame decision scheme. This one-pass scheme calculates the variance of each macroblock in a field and estimates the correlation between two fields. Based on the correlation, a decision to code the picture as a frame or as fields is made. A rate control method for the proposed one-pass scheme is also presented. Simulation results demonstrate that our scheme outperforms frame-only and field-only coding for several sequences coded at a wide range of bit-rates, and the proposed one-pass scheme obtains similar performance as the proposed two-pass scheme.
Characterization of droplet flight path and mass flux in droplet-based manufacturing (1994)

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
Establishment of a Human Allergy Model Using Human IL-3/GM-CSF–Transgenic NOG Mice (2013)

The development of animal models that mimic human allergic responses is crucial to study the pathophysiology of disease and to generate new therapeutic methodologies. Humanized mice reconstituted with human immune systems are essential to study human immune reactions in vivo and are expected to be useful for studying human allergies. However, application of this technology to the study of human allergies has been limited, largely because of the poor development of human myeloid cells, especially granulocytes and mast cells, which are responsible for mediating allergic diseases, in conventional humanized mice. In this study, we developed a novel transgenic (Tg) strain, NOD/Shi-scid-IL2rγ(null) (NOG), bearing human IL-3 and GM-CSF genes (NOG IL-3/GM-Tg). In this strain, a large number of human myeloid cells of various lineages developed after transplantation of human CD34⁺ hematopoietic stem cells. Notably, mature basophils and mast cells expressing FcεRI were markedly increased. These humanized NOG IL-3/GM-Tg mice developed passive cutaneous anaphylaxis reactions when administered anti-4-hydroxy-3-nitrophenylacetyl IgE Abs and 4-hydroxy-3-nitrophenylacetyl. More importantly, a combination of serum from Japanese cedar pollinosis patients and cedar pollen extract also elicited strong passive cutaneous anaphylaxis responses in mice. Thus, to our knowledge, our NOG IL-3/GM-Tg mice are the first humanized mouse model to enable the study of human allergic responses in vivo and are excellent tools for preclinical studies of allergic diseases.
Phase I Trial of the Trifunctional Anti-HER2 × Anti-CD3 Antibody Ertumaxomab in Metastatic Breast Cancer (2006)

Treatment with triple infusions of ertumaxomab yields a strong immunologic response. Doses up to 100 microg can be safely infused with close monitoring of patients. The observed clinical responses are encouraging and indicate antitumor efficacy.
Cloud-based robot grasping with the google object recognition engine (2013)

Rapidly expanding internet resources and wireless networking have potential to liberate robots and automation systems from limited onboard computation, memory, and software. “Cloud Robotics” describes an approach that recognizes the wide availability of networking and incorporates open-source elements to greatly extend earlier concepts of “Online Robots” and “Networked Robots”. In this paper we consider how cloud-based data and computation can facilitate 3D robot grasping. We present a system architecture, implemented prototype, and initial experimental data for a cloud-based robot grasping system that incorporates a Willow Garage PR2 robot with onboard color and depth cameras, Google's proprietary object recognition engine, the Point Cloud Library (PCL) for pose estimation, Columbia University's GraspIt! toolkit and OpenRAVE for 3D grasping and our prior approach to sampling-based grasp analysis to address uncertainty in pose. We report data from experiments in recognition (a recall rate of 80% for the objects in our test set), pose estimation (failure rate under 14%), and grasping (failure rate under 23%) and initial results on recall and false positives in larger data sets using confidence measures.
In Vivo Gene Delivery and Expression of Physiological Levels of Functional Human Factor VIII in Mice (1995)

Hemophilia A is caused by blood coagulation factor VIII (FVIII) deficiency and is an attractive target for gene therapy. However, features of FVIII physiology, such as the instability of the mRNA and protein, have provided obstacles to the design of a feasible strategy for the transfer and expression of the human FVIII gene in vivo. We have constructed a recombinant adenoviral vector, Av1ALH81, that contains the human FVIII cDNA from which the B-domain has been deleted (BDD FVIII) and extensively characterized this vector in vitro and in vivo. In vitro, HepG2, human hepatoma cells, transduced with Av1ALH81 secreted high levels of biologically active human BDD FVIII measured by the Coatest bioassay (> 2,400 mU per 10(6) cells per 24 hr). Administration of Av1ALH81 to mice, via tail vein, resulted in expression of human BDD FVIII in the mouse plasma at levels averaging 307 +/- 93 ng/ml 1 week post-injection, measured by a sensitive human FVIII-specific ELISA. Normal FVIII levels in humans are 100-200 ng/ml, and therapeutic levels are as low as 10 ng/ml. Purification of the human FVIII from the mouse plasma, and subsequent Coatest analysis, revealed that the human FVIII produced in the mice was biologically active. In addition, the duration of FVIII expression in vivo was followed, and high-level FVIII expression was sustained over a period of several weeks. The finding that an adenoviral vector can mediate high-level expression of human FVIII in an animal model provides the basis for the development of gene therapy for hemophilia A.
The Severity of Autism Is Associated with Toxic Metal Body Burden and Red Blood Cell Glutathione Levels (2009)

This study investigated the relationship of children's autism symptoms with their toxic metal body burden and red blood cell (RBC) glutathione levels. In children ages 3-8 years, the severity of autism was assessed using four tools: ADOS, PDD-BI, ATEC, and SAS. Toxic metal body burden was assessed by measuring urinary excretion of toxic metals, both before and after oral dimercaptosuccinic acid (DMSA). Multiple positive correlations were found between the severity of autism and the urinary excretion of toxic metals. Variations in the severity of autism measurements could be explained, in part, by regression analyses of urinary excretion of toxic metals before and after DMSA and the level of RBC glutathione (adjusted R(2) of 0.22-0.45, P < .005 in all cases). This study demonstrates a significant positive association between the severity of autism and the relative body burden of toxic metals.
Feasibility of micro power supplies for MEMS (1997)

Most microelectromechanical systems (MEMS) designed today use macroscopic power supplies, thereby placing limits on the functionality of MEMS in many applications. An alternative to this approach is to design MEMS with integral microscopic distributed power supplies. This paper examines the feasibility of creating micro power supplies by considering three functions common to MEMS power systems: (1) capture energy; (2) store energy; and (3) drive actuation, of these, only the capture energy function is highly dependent on the specific application. For each of the three functions, a table is presented which compares various means of performing the function. This information makes it possible to determine what design alternatives are feasible for the creation of a micro power supply for any specific application of MEMS. We use smart bearings with active surface features as an example application and develop a design for a micro power supply suitable for this work.
Conducting polymer actuators (2000)

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus. (1991)

An enzyme-linked immunosorbent assay (ELISA) was developed for serological diagnosis of hepatitis C virus (HCV) infection, using HCV core protein (p22) synthesized by a recombinant baculovirus. Among 58 clinically well-defined chronic non-A, non-B hepatitis (NANBH) patients, 49 (84.5%) were positive for p22 antibody (anti-p22), whereas 42 (72.4%) were positive for C100-3 antibody (anti-C100-3), as measured by the present assay using the HCV nonstructural protein as antigen. Thirty-nine patients (67.2%) had both antibodies. No significant level of anti-p22 was detected in sera of chronic hepatitis B patients or normal blood donors. In typical post-transfusion NANBH patients, anti-p22 could be detected at, or even before, the first alanine aminotransferase peak. Anti-p22 was also detected in blood donors who were previously shown to be involved in transmitting HCV but in whose serum anti-C100-3 was not detectable. The ELISA detecting antibody to the HCV core protein expressed and properly processed in animal cells will be useful for mass screening of donor blood as well as for early diagnosis of hepatitis C.
Synthesis of (R)-serine-2-d and its conversion to the broad-spectrum antibiotic fludalanine (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of (R)-serine-2-d and its conversion to the broad-spectrum antibiotic fludalaninePaul J. Reider, Robin S. Eichen Conn, Paul Davis, Victor J. Grenda, Arthur J. Zambito, and Edward J. J. GrabowskiCite this: J. Org. Chem. 1987, 52, 15, 3326–3334Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/jo00391a029https://doi.org/10.1021/jo00391a029research-articleACS PublicationsRequest reuse permissionsArticle Views1759Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Enzymatic Dihydroxylation of Aromatics in Enantioselective Synthesis: Expanding Asymmetric Methodology (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Characterization of adult human marrow hematopoietic progenitors highly enriched by two-color cell sorting with My10 and major histocompatibility class II monoclonal antibodies. (1987)

Monoclonal antibodies, My10 (HPCA-1) and major histocompatibility class II (HLA-DR), were used to enrich and phenotype normal human marrow colony-forming unit: granulocyte-macrophage (CFU-GM), burst-forming unit: erythroid (BFU-E), and multipotential colony-forming unit: granulocyte-erythroid-macrophage-megakaryocyte (CFU-GEMM) progenitor cells. Nonadherent low density T lymphocyte-depleted marrow cells were sorted on a Coulter Epics 753 dye laser flow cytometry system with the use of Texas Red-labeled anti-My10 and phycoerythrin conjugated anti-HLA-DR. Cells were separated into populations with nondetectable expression of antigens (DR-My10-) or with constant expression of one antigen and increasing densities of the other antigen. More than 98% of the CFU-GM, BFU-E, and CFU-GEMM were found in fractions containing cells expressing both HLA-DR and My10 antigens. The cloning efficiency (CE) of cells in the DR-My10- cell fraction was 0.01%. In the antigen-positive sorted fractions, the CE was highest (up to 47%) in the fractions of cells expressing high My10 and low DR (My10 DR+) antigens and was lowest (2.5%) in the fraction of cells expressing low My10 and low DR (My10+DR+) antigens. Populations of cells varying in the density of HLA-DR, but not My10, antigens varied in the proportion and types of progenitor cells present. When My10-positive cells were sorted for HLA-DR density expression, the CE for CFU-GM was similar in the DR+ and DR++ fractions, but most of the BFU-E and CFU-GEMM were found in the DR+ fraction. Within the CFU-GM compartment, most of the eosinophil progenitors were found in the DR+ fraction, whereas a greater proportion of macrophage progenitors were detected in the DR++ fraction. CFU-GM and BFU-E in the fractions of cells positive for DR and My10 were assessed for responsiveness to the effects of recombinant human tumor necrosis factor-alpha, recombinant human interferon-gamma, and prostaglandin E1. Colony formation from CFU-GM was suppressed by the three molecules, and colony formation by BFU-E was suppressed by recombinant human tumor necrosis factor-alpha and interferon-gamma and enhanced, in the presence of T lymphocyte-conditioned medium, by prostaglandin E1 in all antigen-positive fractions.(ABSTRACT TRUNCATED AT 400 WORDS)
Role of Poly(amidoamine) Dendrimers for Preparing Nanoparticles of Gold, Platinum, and Silver (2000)

Nanoparticles of gold, platinum, and silver were prepared by reduction of their metal salts with NaBH4 in the presence of poly(amidoamine) dendrimers. The dendrimers used were generation 3, 4, and 5 having surface amino group (G3, G4, and G5) as well as generation 3.5, 4.5, and 5.5 having surface carboxyl group (G3.5, G4.5, and G5.5). The metal nanoparticles obtained were characterized by UV−vis spectroscopy and transmission electron microscopy. By using G3−G5, gold nanoparticles in the 1.5−4.0 nm size regime were obtained where their size decreased with increasing concentration of the dendrimers as well as the generation of the dendrimers. Similarly, platinum nanoparticles with a diameter of 2.4−3.0 nm were obtained, and their size was insensitive against the concentration as well as the generation of G3−G5. In the case of silver nanoparticles, very small silver particles using G3.5−G5.5 were obtained. In addition, the dendrimer concentration required for obtaining stable nanoparticles was found to be dependent on the interactions between metal nanoparticles and the dendrimers: when the ratio of [surface group of dendrimer]/[metal salt] was above unity, nanoparticles of gold and silver were obtained, while stable platinum nanoparticles were only obtained above the ratio of 40/1. From infrared spectroscopy it is suggested that the metal nanoparticles adsorb on the exteriors of the dendrimers.
————‐Immunological Properties of Rickettsia tsutsugamushi Kawasaki Strain, Isolated from a Patient in Kyushu (1986)

Nine isolates of Rickettsia tsutsugamushi were obtained from patients with Tsutsugamushi disease (scrub typhus) in Miyazaki Prefecture in Kyushu. Immunological analyses of these patients' sera and the isolates were performed by indirect immunofluorescence, indirect immunoperoxidase or immunoblotting techniques. In the analysis of reactions of the patients' sera with the prototype strains Gilliam, Karp, and Kato and with the isolates, sera from two patients, including Kawasaki, showed similar profiles and cross-reaction with the two isolates recovered from the corresponding patients, but reacted only weakly with the prototype strains. With guinea pig polyclonal antibodies against the isolate and prototype strains, Kawasaki strain showed some degree of cross-reaction with Gilliam strain but not with either Karp or Kato strain, nor with Shimokoshi strain which is known to be different antigenically from the prototype strains. Additionally, strain-specific murine monoclonal antibodies against Gilliam, Karp, and Kato strains did not react at all with Kawasaki strain. These results suggest that the Kawasaki strain may be different antigenically from the prototype strains and Shimokoshi strain. The finding two strains of the same antigenic type (Kawasaki) among only nine isolates suggests the presence of Kawasaki-type rickettsiae in Miyazaki Prefecture. Shimokoshi strain also did not react with these strain-specific monoclonal antibodies, suggesting that strains of R. tsutsugamushi antigenically distinct from the prototype strains, such as Kawasaki and Shimokoshi strains, may easily be recognized by their nonreactivity with these monoclonal antibodies.
A Microionizer for Portable Mass Spectrometers Using Double-Gated Isolated Vertically Aligned Carbon Nanofiber Arrays (2011)

We report a gas ionizer based on arrays of microfabricated double-gated isolated vertically aligned carbon nanofibers (VA-CNFs) for application in low-power portable mass spectrometers. Field-emitted electrons from VA-CNFs are accelerated to high energy and subsequently collide with neutral gas molecules, leading to ionization/fragmentation of the molecules. Double-gated field-emitter arrays with isolated VA-CNF tips were fabricated using a photoresist planarization technique. Two types of devices were fabricated and characterized. The first type of device has the emitter tip in the same plane as the extraction gate, and the second type of device has the emitter tip 900 nm below the extraction gate. All devices were made using a process that results in gate and focus diameters of 1.7 and 4.2 μm, respectively. When operated as a field-emitted electron impact ionizer (EII), for the same ion current, the ionization efficiency (ratio of ions to emitted electrons) increased from 0.005 to 0.05 as the pressure is increased between 5×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> and 1×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> torr. In comparison with EIIs based on thermionic electron sources, the power dissipation reduced from >;1 W to 100 mW.