gebhart/patrepeval huggingface dataset:
Torque Nonuniformity Measurements in Gasoline Fueled Passenger Cars Equipped with Automatic Transmission - Theory and Experimental Results (1986)

&lt;div class="htmlview paragraph"&gt;This paper presents theory and experiments results for a noncontacting method of measuring reciprocating IC engine torque nonuniformity. This method yields an index of torque nonuniformity which is potentially useful for detecting abnormal engine operation and has important application for control and diagnostic functions. The nonuniformity index can be computed for each engine cycle if desired or averaged over many cycles. The method also has the capability of detecting intermittent abnormal operations.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper explains the nonuniformity index and describes noncontacting instrumentation with which it can be measured. The results of experimental measurements of the nonuniformity index in actual operation of a vechicle equipped with an automatic transmission are presented. The statistical distribution of this index is shown to be such that abnormal engine operation can be reliably detected even if such operation occurs infrequently.&lt;/div&gt;
Reproducibility of internal atrial defibrillation threshold in paroxysmal and persistent atrial fibrillation (2004)

ADFT is reproducible in paroxysmal AF patients, while a high coefficient of variability is present in persistent AF, possibly related to different patterns of re-entrant circuits in the reinduced AF. This observation is important in order to evaluate factors influencing ICV-ADFT correctly in AF patients.
Transmitter Power Control for Co-Channel Interference Management in Cellular Radio Systems - An Overview and some Recent Results (1993)

Transmitter Power Control for Co-Channel Interference Management in Cellular Radio Systems - An Overview and some Recent Results
Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis (1990)

Fifteen patients (30 to 78 years of age) with diagnoses of rheumatoid arthritis were administered oral and intravenous methotrexate (15 mg), alone or with concomitant naproxen (1000 mg/day). Serial blood samples and urine were collected for 24 hours after the dose of methotrexate and were assayed for methotrexate by a specific radioenzymatic method. In twelve patients who completed the study, methotrexate systemic clearance was not statistically different with naproxen (103.3 +/- 35.0 ml/min) versus without naproxen (113.4 +/- 48.3 ml/min; p = 0.37). Oral clearance of methotrexate was not statistically different with naproxen (161.7 +/- 55.0 ml/min) versus without naproxen (176.7 +/- 68.3 ml/min; p = 0.14). Likewise, there was not a significant difference in methotrexate renal clearance or plasma protein binding with or without naproxen. No toxicity was observed when patients received methotrexate alone or with naproxen. This study indicates that concomitant naproxen does not abruptly alter the disposition of low-dose methotrexate in patients with rheumatoid arthritis who have normal renal function.
Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo (1998)

Peptide nucleic acids (PNAs) are DNA analogs that can hybridize to complementary sequences with high affinity and stability. Here, we report the first evidence of intracellular delivery of PNAs in vivo. Two CNS receptors, an opioid (mu) and a neurotensin (NTR-1), were targeted independently by repeated microinjection of PNAs into the periaqueductal gray. Behavioral responses to neurotensin (antinociception and hypothermia) and morphine (antinociception) were lost in a specific manner. Binding studies confirmed a large reduction in receptor sites. The loss of behavioral responses was long lasting but did fully recover. The implications of specifically and readily turning off gene expression in vivo are profound.
Estimates of the worldwide incidence of eighteen major cancers in 1985 (1993)

The annual incidence rates (crude and age-standardized) and numbers of new cases of 18 different cancers have been estimated for the year 1985 in 24 areas of the world. The total number of new cancer cases (excluding non-melanoma skin cancer) was 7.6 million, 52% of which occur in developing countries. The most common cancer in the world today is lung cancer, accounting for 17.6% of cancers of men worldwide, and 22% of cancers in men in the developed countries. Stomach cancer is now second in frequency (it was slightly more common than lung cancer in 1980) and breast cancer--by far the most important cancer of women (19.1% of the total)--is third. There are very large differences in the relative importance of the different cancers by world area. The major cancers of developed countries (other than the 3 already named) are cancers of the colon-rectum and prostate, and, in developing countries, cancers of the cervix uteri, mouth and pharynx, liver and oesophagus. The implications of these patterns for cancer control, and specifically prevention, are discussed. Tobacco smoking and chewing are almost certainly the major preventable causes of cancer today.
A P element containing suppressor of hairy-wing binding regions has novel properties for mutagenesis in Drosophila melanogaster. (1995)

P elements are widely used as insertional mutagens to tag genes, facilitating molecular cloning and analyses. We modified a P element so that it carried two copies of the suppressor of Hairy-wing [su(Hw)] binding regions isolated from the gypsy transposable element. This transposon was mobilized, and the genetic consequences of its insertion were analyzed. Gene expression can be altered by the su(Hw) protein as a result of blocking the interaction between enhancer/silencer elements and their promoter. These effects can occur over long distances and are general. Therefore, a composite transposon (SUPor-P for suppressor-P element) combines the mutagenic efficacy of the gypsy element with the controllable transposition of P elements. We show that, compared to standard P elements, this composite transposon causes an expanded repertoire of mutations and produces alleles that are suppressed by su(Hw) mutations. The large number of heterochromatic insertions obtained is unusual compared to other insertional mutagenesis procedures, indicating that the SUPor-P transposon may be useful for studying the structural and functional properties of heterochromatin.
Oxidative Mechanisms Involved in Lignin Degradation by White-Rot Fungi (2001)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxidative Mechanisms Involved in Lignin Degradation by White-Rot FungiRimko ten Have and Pauline J. M. TeunissenView Author Information Division of Industrial Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University and Research Centre, P.O. Box 8129, 6700 EV Wageningen, The Netherlands, and Genencor International B.V., Archimedesweg 30, 2333 CN Leiden, The Netherlands Cite this: Chem. Rev. 2001, 101, 11, 3397–3414Publication Date (Web):October 19, 2001Publication History Received12 April 2001Published online19 October 2001Published inissue 1 November 2001https://pubs.acs.org/doi/10.1021/cr000115lhttps://doi.org/10.1021/cr000115lresearch-articleACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views6230Altmetric-Citations410LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biopolymers,Organic polymers,Oxidation,Peptides and proteins,Transition metals Get e-Alerts
Simvastatin Reduces Neointimal Thickening in Low-Density Lipoprotein Receptor–Deficient Mice After Experimental Angioplasty Without Changing Plasma Lipids (2002)

Simvastatin modulates vascular repair after injury in the absence of lipid-lowering effects. Although the mechanisms are not yet established, additional research may lead to new understanding of the actions of statins and novel therapeutic interventions for preventing restenosis.
Biochemical engineering fundamentals (1977)

Biochemical Engineering Fundamentals, 2/e, combines contemporary engineering science with relevant biological concepts in a comprehensive introduction to biochemical engineering. The biological background provided enables students to comprehend the major problems in biochemical engineering and formulate effective solutions.
Gene Controlling the Uptake of Shikimic Acid by Escherichia coli (1966)

Pittard, James (University of Melbourne, Melbourne, Australia), and B. J. Wallace. Gene controlling the uptake of shikimic acid by Escherichia coli. J. Bacteriol. 92:1070-1075. 1966.-Mutants possessing an impaired ability to take up exogenously supplied shikimic acid were isolated. Mutants showing either a complete or partial loss of this activity were found. The mutations have been mapped on the Escherichia coli chromosome and occur in a single gene, situated near to the cluster of genes concerned with histidine biosynthesis. The uptake of dehydroshikimic acid was also affected by these mutations, suggesting a common mechanism for the uptake of these two related intermediates of aromatic biosynthesis.
Isolation of human simple repeat loci by hybridization selection (1994)

We have isolated short tandem repeat arrays from the human genome, using a rapid method involving filter hybridization to enrich for tri- or tetranucleotide tandem repeats. About 30% of clones from the enriched library cross-hybridize with probes containing trimeric or tetrameric tandem arrays, facilitating the rapid isolation of large numbers of clones. In an initial analysis of 54 clones, 46 different tandem arrays were identified. Analysis of these tandem repeat loci by PCR showed that 24 were polymorphic in length; substantially higher levels of polymorphism were displayed by the tetrameric repeat loci isolated than by the trimeric repeats. Primary mapping of these loci by linkage analysis showed that they derive from 17 chromosomes, including the X chromosome. We anticipate the use of this strategy for the efficient isolation of tandem repeats from other sources of genomic DNA, including DNA from flow-sorted chromosomes, and from other species.
A delay-based approach for congestion avoidance in interconnected heterogeneous computer networks (1989)

In heterogeneous networks, achieving congestion avoidance is difficult because the congestion feedback from one subnetwork may have no meaning to sources on other subnetworks. We propose using changes in round-trip delay as an implicit feedback. Using a black-box model of the network, we derive an expression for the optimal window as a function of the gradient of the delay-window curve.The problems of selfish optimum and social optimum are also addressed. It is shown that without a careful design, it is possible to get into a race condition during heavy congestion, where each user wants more resources than others, thereby leading to a diverging condition.It is shown that congestion avoidance using round-trip delay is a promising approach. The approach has the advantage that there is absolutely no overhead for the network itself. It is exemplified by a simple scheme. The performance of the scheme is analyzed using a simulation model. The scheme is shown to be efficient, fair, convergent, and adaptive to changes in network configuration.The scheme as described works only for networks which can be modeled with queueing servers with constant service times. Further research is required to extend it for implementation in practical networks. Several directions for future research have been suggested.
Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin (2010)

The integrins Mac-1, LFA-1 and, interestingly, VLA-4 mediate the adhesion of sickle cell disease leukocytes to activated endothelial cell layers, in vitro. Our data indicate that simvastatin may be able to reduce endothelial activation and consequent leukocyte adhesion in this in vitro model; future experiments and clinical trials may determine whether simvastatin therapy could be employed in patients with sickle cell disease, with beneficial effects on vaso-occlusion.
Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems. (1990)

In Escherichia coli, selection of the proper division site at midcell requires the specific inhibition of septation at two other potential division sites, located at each of the cell poles. This site-specific inhibition of septation is mediated by the gene products of the minicell locus (the minB operon) that includes three genes, minC, minD, and minE. In this paper we show that one of the components of this division-inhibition system, the minC gene product, is also an essential component of another division-inhibition system, which is induced by derepression of the dicB gene and leads to inhibition of septation at all potential division sites. The two minC-dependent division-inhibition systems could be functionally distinguished by their different responses to the minE gene product. The results suggest a model in which a common mechanism, mediated by MinC, is responsible for the division block in a class of division-inhibition systems that can be independently activated by different proteins that determine the specific properties of these systems.
Establishment of a Ph 1 chromosome‐positive cell line from chronic myelogenous leukemia in blast crisis (1983)

A new hematopoietic cell line, designated KCL-22, was established in vitro by cultivation of pleural effusion cells obtained from a woman with chronic myelogenous leukemia in blast crisis. KCL-22 grew in suspension culture with a doubling time of 24 h and consisted of immature undifferentiated cells which were positive for periodic acid-Schiff and acid phosphatase staining. Chromosome analysis of the KCL-22 line showed a female karyotype with double Ph1 chromosomes and additional chromosome abnormalities. Its representative karyotype was 52,XX, + 1p-,+6,+8,+8,+8, t(9q+;22q-), +22q-. This cell line possessed receptors for the Fc portion of IgG, but lacked lymphoid cell characteristics and the Epstein-Barr virus-associated nuclear antigen. These results indicate that the KCL-22 cells were derived from chronic myelogenous leukemia cells. This cell line should prove useful for research involving various aspects of chronic myelogenous leukemia.
The Influence of Heterogeneous Optical Properties on Fluorescence Diffusion Tomography of Small Animals (2006)

We evaluated the influence of optical property maps on inversion of fluorescence data from mice. For highly absorbing regions (5x background) of sufficient size, heterogeneous optical property maps provide significant improvements over homogeneous maps.
Work/Family Border Theory: A New Theory of Work/Family Balance (2000)

This article introduces work/family border theory - a new theory about work/family balance. According to the theory, people are daily border-crossers between the domains of work and family. The theory addresses how domain integration and segmentation, border creation and management, border-crosser participation, and relationships between border-crossers and others at work and home influence work/family balance. Propositions are given to guide future research.
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma (2007)

A t(2;5) chromosomal translocation resulting in expression of an oncogenic kinase fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been implicated in the pathogenesis of anaplastic large-cell lymphoma (ALCL). PF-2341066 was recently identified as a p.o. bioavailable, small-molecule inhibitor of the catalytic activity of c-Met kinase and the NPM-ALK fusion protein. PF-2341066 also potently inhibited NPM-ALK phosphorylation in Karpas299 or SU-DHL-1 ALCL cells (mean IC(50) value, 24 nmol/L). In biochemical and cellular screens, PF-2341066 was shown to be selective for c-Met and ALK at pharmacologically relevant concentrations across a panel of >120 diverse kinases. PF-2341066 potently inhibited cell proliferation, which was associated with G(1)-S-phase cell cycle arrest and induction of apoptosis in ALK-positive ALCL cells (IC(50) values, approximately 30 nmol/L) but not ALK-negative lymphoma cells. The induction of apoptosis was confirmed using terminal deoxyribonucleotide transferase-mediated nick-end labeling and Annexin V staining (IC(50) values, 25-50 nmol/L). P.o. administration of PF-2341066 to severe combined immunodeficient-Beige mice bearing Karpas299 ALCL tumor xenografts resulted in dose-dependent antitumor efficacy with complete regression of all tumors at the 100 mg/kg/d dose within 15 days of initial compound administration. A strong correlation was observed between antitumor response and inhibition of NPM-ALK phosphorylation and induction of apoptosis in tumor tissue. In addition, inhibition of key NPM-ALK signaling mediators, including phospholipase C-gamma, signal transducers and activators of transcription 3, extracellular signal-regulated kinases, and Akt by PF-2341066 were observed at concentrations or dose levels, which correlated with inhibition of NPM-ALK phosphorylation and function. Collectively, these data illustrate the potential clinical utility of inhibitors of NPM-ALK in treatment of patients with ALK-positive ALCL.
Urea improves efficiency of bisulphite-mediated sequencing of 5'- methylcytosine in genomic DNA (1998)

The detection of 5'-methylcytosine by the bisulphite-mediated genomic sequencing method has considerably aided study of the role of methylation in areas such as X chromosome inactivation, genomic imprinting and cancer research. However on occasion difficulty has been experienced in obtaining complete conversion of cytosine to uracil in regions of the target DNA. We report here a simple improvement to the method involving addition of urea to the bisulphite reaction, a step which greatly improves the reaction efficiency, presumably by maintaining the target DNA in single stranded form, thereby allowing complete and reliable conversion.
Gene Targeting by Homologous Recombination in Drosophila (2000)

Drosophila offers many advantages as an experimental organism. However, in comparison with yeast and mouse, two other widely used eukaryotic model systems, Drosophila suffers from an inability to perform homologous recombination between introduced DNA and the corresponding chromosomal loci. The ability to specifically modify the genomes of yeast and mouse provides a quick and easy way to generate or rescue mutations in genes for which a DNA clone or sequence is available. A method is described that enables analogous manipulations of the Drosophila genome. This technique may also be applicable to other organisms for which gene-targeting procedures do not yet exist.
A Second Leukotriene B4 Receptor, Blt2 (2000)

Leukotriene B(4) (LTB(4)) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB(4) appear to be mediated by a specific G protein-coupled receptor (GPCR) BLT1, originally termed BLT (Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. Nature. 387:620-624). Here, we report the molecular cloning of a novel GPCR for LTB(4), designated BLT2, which binds LTB(4) with a Kd value of 23 nM compared with 1.1 nM for BLT1, but still efficiently transduces intracellular signaling. BLT2 is highly homologous to BLT1, with an amino acid identity of 45.2%, and its open reading frame is located in the promoter region of the BLT1 gene. BLT2 is expressed ubiquitously, in contrast to BLT1, which is expressed predominantly in leukocytes. Chinese hamster ovary cells expressing BLT2 exhibit LTB(4)-induced chemotaxis, calcium mobilization, and pertussis toxin-insensitive inhibition of adenylyl cyclase. Several BLT1 antagonists, including U 75302, failed to inhibit LTB(4) binding to BLT2. Thus, BLT2 is a pharmacologically distinct receptor for LTB(4), and may mediate cellular functions in tissues other than leukocytes. BLT2 provides a novel target for antiinflammatory therapy and promises to expand our knowledge of LTB(4) function. The location of the gene suggests shared transcriptional regulation of these two receptors.
Improved Pel-Recursive Motion Compensation (1984)

A pel-recursive motion estimation technique for television coding was introduced by Netravali and Robbins [1]. This method basically involves computing a motion displacement and then separating the pels into predictable and unpredictable segments. The addresses required to identify these segments and thus enable the motion estimation algorithm are transmitted along with pel error data. The original algorithms are slow to converge, i.e., many iterations are required to obtain an accurate displacement estimate. This research introduces extensions to the basic algorithm of [1] and offers two significant improvements. First, convergence speed is improved substantially, which means that the algorithms can better tolerate motion changes and diverse motion within the picture. Secondly, explicit address information is not required, as it is contained implicitly in the motion compensation algorithm. For the sequences examined, this method proved superior to that of explicitly transmitting the address data. This algorithm has much better convergence rates and has prediction rates better than the original.
Treatment of Acute Lymphoblastic Leukemia (2006)

Although the overall cure rate of acute lymphoblastic leukemia (ALL) in children is about 80 percent, affected adults fare less well. This review considers recent advances in the treatment of ALL, emphasizing issues that need to be addressed if treatment outcome is to improve further.