gebhart/patrepeval huggingface dataset:
[Multicenter clinical evaluation of red cell concentrates stored up to 6 weeks in MAP, a new additive solution]. (1992)

The clinical safety and efficacy of transfusion of red cell concentrates stored in MAP solution (MAP-CRC) containing mannitol, adenine, glucose, phosphate and citrate, into 39 anemic patients were evaluated. In 23 patients, infusion of MAP-CRC was alternated with infusion of ordinary CRC as a control. The MAP-CRC and CRC used in this study were stored at 4 degrees C for an average of 38.2 +/- 2.6 days (n = 52) and 18.1 +/- 2.2 days (n = 26), respectively. Red cell recovery was 77.5% for MAP-CRC and 82.5% for CRC, based on calculation of the increase in hemoglobin level one day after transfusion. There were no differences between patients transfused with MAP-CRC and those transfused with CRC in clinical findings or biochemical data. No major side-effects other than pyrexia associated with the underlying infections were seen in patients transfused with MAP-CRC. MAP-CRC stored up to 42 days is apparently as safe and effective as stored CRC. This new additive solution may therefore be useful for the future expansion of the indications for autologous blood transfusion by facilitating the collection and storage of more blood in the liquid state for a longer period, and may also be useful in obtaining more plasma from whole blood as source plasma.
Hybrid scheduling for parallel rendering using coherent ray tasks (1999)

Parallelising ray tracing with a data parallel approach allows rendering of arbitrarily large models, but the inherent load imbalances may lead to severe inefficiencies. To compensate for the uneven load distribution, demand-driven tasks may be split off and scheduled to processors that are less busy. We propose a hybrid scheduling algorithm which brings tasks and data together according to coherence between rays. The amount of demand-driven versus data-parallel tasks is a function of the coherence between rays and the amount of imbalance in the basic data-parallel load.
Manipulation of microparticles using phase-controllable ultrasonic standing waves (2010)

A method of manipulating microparticles in a liquid using ultrasound is proposed and demonstrated. An ultrasonic standing wave with nodal planes whose positions are controllable by varying the relative phase of two applied sinusoidal signals is generated using a pair of acoustically matched piezoelectric transducers. The resulting acoustic radiation force is used to trap micron scale particles at a series of arbitrary positions (determined by the relative phase) and then move them in a controlled manner. This method is demonstrated experimentally and 5 μm polystyrene particles are trapped and moved in one dimension through 140 μm.
Script-Independent Text Line Segmentation in Freestyle Handwritten Documents (2008)

Text line segmentation in freestyle handwritten documents remains an open document analysis problem. Curvilinear text lines and small gaps between neighboring text lines present a challenge to algorithms developed for machine printed or hand-printed documents. In this paper, we propose a novel approach based on density estimation and a state-of-the-art image segmentation technique, the level set method. From an input document image, we estimate a probability map, where each element represents the probability that the underlying pixel belongs to a text line. The level set method is then exploited to determine the boundary of neighboring text lines by evolving an initial estimate. Unlike connected component based methods ( [1], [2] for example), the proposed algorithm does not use any script-specific knowledge. Extensive quantitative experiments on freestyle handwritten documents with diverse scripts, such as Arabic, Chinese, Korean, and Hindi, demonstrate that our algorithm consistently outperforms previous methods [1]-[3]. Further experiments show the proposed algorithm is robust to scale change, rotation, and noise.
Structure–Activity Relationships among Antifungal Nylon-3 Polymers: Identification of Materials Active against Drug-Resistant Strains of Candida albicans (2014)

Fungal infections are a major challenge to human health that is heightened by pathogen resistance to current therapeutic agents. Previously, we were inspired by host-defense peptides to develop nylon-3 polymers (poly-β-peptides) that are toxic toward the fungal pathogen Candida albicans but exert little effect on mammalian cells. Based on subsequent analysis of structure-activity relationships among antifungal nylon-3 polymers, we have now identified readily prepared cationic homopolymers active against strains of C. albicans that are resistant to the antifungal drugs fluconazole and amphotericin B. These nylon-3 polymers are nonhemolytic. In addition, we have identified cationic-hydrophobic copolymers that are highly active against a second fungal pathogen, Cryptococcus neoformans, and moderately active against a third pathogen, Aspergillus fumigatus.
SYBASE and Client/Server Computing (1996)

From the Publisher:
A logical extension of Alex Berson's highly successful Client/Server Architecture, this surefire guide shows you how to take full advantage of SYBASE - one of the most popular relational database management systems on the market today. The book analyzes in detail the SYBASE client/server architecture and explores all major implementations, fully explaining the concepts, facilities, and advantages of client/server computing. An indispensable tool for systems designers and systems and applications programmers, SYBASE and Client/Server Computing offers you complete information on: SYBASE System 10 and follow-on products; basic features of all the important operating systems that implement SYBASE, including UNIX, OS/2, Windows NT, AIX, HP-UX, Sun-OS, Solaris, and NetWare; emerging and de facto industry standards such as OSF's DCE, IBM's DRDA, and OMG's CORBA; and the implementation of SYBASE with PowerSoft's PowerBuilder and GainMomentum. You'll also get practical guidance on SYBASE system and database design and administration, covering SYBASE installation, hardware, and software requirements ... connectivity with mainframe and other databases ... backup and recovery replication ... parallel data implementation ... and sample application programs written for SYBASE SQL Server, SYBASE Net/Gateway, and SYBASE Open Server.
Expression and Initial Characterization of a Recombinant Human Thrombospondin Heparin Binding Domain (1989)

Thrombospondin (TSP) is a trimeric glycoprotein of Mr 420,000. It was originally described as a major component of human platelet alpha granules and is essential for the secondary phase of platelet aggregation. TSP is also synthesized and secreted by a variety of nucleated cells where it functions in processes involving growth and adhesion of cells to the extracellular matrix. Many of these processes are heparin-inhibitable and are mediated by a proteolytic fragment of TSP called the heparin binding domain (HBD). In order to facilitate the analysis of the structure and function(s) of this domain, we have expressed this molecule in Escherichia coli. A fragment of a TSP cDNA that encodes the heparin binding domain was inserted into the prokaryotic expression vector pJBL6. In bacterial cells grown at 42 degrees C, this vector directs the synthesis of a 24,000-Da polypeptide. Milligram quantities of this protein were purified to homogeneity from E. coli lysates. The structure of the recombinant HBD was confirmed by protein sequencing. The protein was further characterized by analysis of its conformation and function. The recombinant HBD binds [3H]heparin with a Kd of 71 nM, almost identical to that of TSP-derived HBD (80 nM). Additionally, the recombinant HBD is able to compete for TSP binding to 11B carcinoma cells. These studies indicate that the recombinant HBD is synthesized and purified in a native configuration and is functionally equivalent to thrombospondin-derived HBD. They further indicate that glycosylation of the thrombospondin HBD is not necessary for its interaction with heparin and that sequences essential to this interaction reside within the first 229 amino acids of secreted thrombospondin.
Desensitization by Sensitizing Dyes (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesensitization by Sensitizing DyesJohn Spence and B. H. CarrollCite this: J. Phys. Chem. 1948, 52, 6, 1090–1103Publication Date (Print):June 1, 1948Publication History Published online1 May 2002Published inissue 1 June 1948https://doi.org/10.1021/j150462a019RIGHTS & PERMISSIONSArticle Views24Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (604 KB) Get e-Alerts
Amino acid sequence of a mouse mucosal mast cell protease (1989)

The amino acid sequence has been determined of a mouse mucosal mast cell protease isolated from the small intestines of mice infected with Trichinella spiralis. The active protease contains 226 residues. Those corresponding to the catalytic triad of the active site of mammalian serine proteases (His-57, Asp-102, and Ser-195 in chymotrypsin) occur in identical positions. A computer search for homology indicates 74.3% and 74.1% sequence identity of the mouse mast cell protease compared to those of rat mast cell proteases I and II (RMCP I and II), respectively. The six half-cystine residues in the mouse mast cell protease are located in the same positions as in the rat mast cell proteases, cathepsin G, and the lymphocyte proteases, suggesting that they all have identical disulfide bond arrangements. At physiological pH, the mouse and rat mucosal mast cell proteases have net charges of +3 and +4, respectively, as compared to +18 for the protease (RMCP I) from rat connective tissue mast cells. This observation is consistent with the difference in solubility between the mucosal and connective tissue mast cell proteases when the enzymes are extracted from their granules under physiological conditions.
Compatibility of filgrastim with selected drugs during simulated Y-site administration (1994)

The compatibility of filgrastim with selected drugs during simulated Y-site injection was studied. Five-milliliter samples of filgrastim 30 micrograms/mL in 5% dextrose injection were combined with 5-mL samples of solutions of each of 97 other drugs in 5% dextrose injection at clinically used concentrations at 22 degrees C. Immediately after and one and four hours after the samples were combined, visual examinations were performed in fluorescent light with the unaided eye and with a high-intensity monodirectional light (Tyndall beam) to enhance the visualization of small particles and low-level turbidity. The turbidity of each drug combination was measured as well. Combinations yielding inconclusive results were subjected to particle sizing and counting. Most of the drugs tested were compatible with filgrastim 30 micrograms/mL during the observation period. However, 22 drugs showed various incompatibilities with filgrastim, including filament formation, particulate formation and precipitation, and color change. Filgrastim 30 micrograms/mL in 5% dextrose injection was compatible with 75 drugs for up to four hours at 22 degrees C; 22 drugs were not compatible with filgrastim.
Oracle at Trec8: A Lexical Approach. (1999)

Oracle&amp;apos;s system for Trec8 was the interMedia Text retrieval engine integrated with the Oracle8i database and SQL query language. interMedia Text supports a novel theme-based document retrieval capability using an extensive lexical knowledge base. Trec8 queries constructed by extracting themes from topic titles and descriptions were manually refined. Queries were simple and intuitive. Oracle&amp;apos;s results demonstrate that knowledge-based retrieval is a viable and scalable solution for information retrieval and that statistical training and tuning on the document collection is unnecessary for good performance in Trec. 1. Introduction Oracle&amp;apos;s approach to Trec8 is a novel theme-based retrieval method implemented on top of traditional boolean techniques. Theme-based retrieval enables querying for documents that are about a certain theme or concept. The set of themes from a document together define what a document is about. Themes are extracted from documents and queries by parsing them usin...
Tumor behavior in transitional cell carcinoma of the bladder in relation to chromosomal markers and histopathology. (1987)

Tumor cells from direct harvests and short term cultures were karyotyped from 15 patients with transitional cell carcinoma of the bladder. There were two tumors with an apparently normal diploid karyotype, eight with counts up to 50 and with marker chromosomes, and five with counts of 60 or more and with markers. The median duration between recurrences was 3 months for the near-diploid, and 3 months for the near-polyploid tumors. One patient whose tumor was normal diploid had a recurrence at 5 months and the second patient whose tumor had normal diploid tumor had no recurrence over 15 months. Four tumors (27% of the series) had a rearrangement involving band 3p14: three had +der(5)t(3;5)(p14;p14) and one had +der(6)t(1;3;6)(q21;p14;p23). Duplication 3p14----3pter was observed in four tumors, and deletion 11p15----11pter in five. Three other abnormalities were observed in three cases each: deletion 5p14----5pter, duplication 1q23----1q32 and deletion 6q21----6qter. Trisomy 7 was observed as a sole clonal abnormality in one carcinoma in situ. Thirteen of 15 patients had recurrence of their tumor. Tumor progression (either in stage or grade) was evident in seven recurrent tumors. Among the seven with tumor progression, three had 11p deletion, two had 11p deletion plus 3p duplication, one had 3p duplication, and one had trisomy 7. Four of the five that had 11p deletion underwent cystectomy and three have died. Three of eight near-diploid tumors progressed and four of five near-tetraploid tumors progressed. It will be important to characterize any cytogenetic changes that are of prognostic value, since the categorization of bladder tumors by other methods has been problematic.
Pneumotropism of Sendai Virus in Relation to Protease-Mediated Activation in Mouse Lungs (1983)

The pneumotropism of Sendai virus in mice was studied in relation to the activation and replication of the virus in the lung. Inactive Sendai virus grown in LLC-MK(2) cells, which possessed an uncleaved precursor glycoprotein, F, and was noninfectious to tissue culture cells, neither grew nor caused pathological changes in the lung of mice. When trypsin treatment was made which cleaved F into F(1) and F(2) subunits, the virus became activated so that it could initiate replication in the bronchial epithelium of the lung. In this case, the progeny virus was produced in the activated form and multiple-cycle replication occurred successively. A parallel relationship was found between the degree of the viral replication and that of clinical signs of the respiratory disease, body weight loss, and histopathological changes in the lung. A protease mutant, TR-2, which was able to be activated only by chymotrypsin but not by trypsin, could also initiate replication in the bronchial epithelium, when activated by chymotrypsin before inoculation into mice. The progeny virus, however, remained inactive, and the replication was limited to a single cycle, which resulted in the limited lung lesion. The overall results suggest that some activating mechanism for the progeny virus of wild-type Sendai virus exists in the lung of mice and the principle (activator) responsible for this phenomenon has a character similar to trypsin. The possible location of the activator is discussed.
Optical-coherence-reflectometry (OCR)-guided rf ablation guide wire for total occlusions (2001)

One of the last remaining frontiers in angioplasty interventions is successfully recanalizing arteries containing total occlusions. The primary limitation is the inability to pass a guide wire safely across the total occlusion to facilitate therapeutic interventions, such as balloon angioplasty. The Optical Coherence Reflectometry (OCR) guide wire system has demonstrated clinical potential for navigating through total occlusions, but often these lesions are refractory to passage of the guide wire by mechanical force alone. The OCR guide wire has been coupled with low frequency (250-500 kHz), short duration (100 millisecond pulses) radio frequency energy to facilitate guided ablation through the total occlusion. Through a real- time monitoring system and display, the physician is warned if the guide wire approaches the normal arterial wall, allowing the guide wire to be redirected to prevent perforating the vessel. Coupled with the OCR guidance system, the RF ablation allows passage through highly resistant lesions that would not normally be transversed with conventional guide wires. The OCR guided RF guide wire system has been successfully tested in porcine models with cadaveric atherosclerotic diseased arterial grafts.
Toward victory in adult ALL: blinatumomab joins in (2012)

The study by Topp et al in this issue of Blood confirms that blinatumomab can significantly reduce the relapse risk and improve survival in patients with minimal residual disease (MRD)+ B-precursor acute lymphoblastic leukemia (ALL).[1][1]

Blinatumomab is the result of an original translational
Myeloperoxidase Levels and Mortality in Frail Community-Living Elderly Individuals (2010)

Our results obtained from a representative sample of very old and frail elderly individuals expand the knowledge that low levels of MPO are associated with better survival.
Simultaneous Multikernel GPU: Multi-tasking throughput processors via fine-grained sharing (2016)

Studies show that non-graphics programs can be less optimized for the GPU hardware, leading to significant resource under-utilization. Sharing the GPU among multiple programs can effectively improve utilization, which is particularly attractive to systems where many applications require access to the GPU (e.g., cloud computing). However, current GPUs lack proper architecture features to support sharing. Initial attempts are preliminary: They either provide only static sharing, which requires recompilation or code transformation, or they do not effectively improve GPU resource utilization. We propose Simultaneous Multikernel (SMK), a fine-grain dynamic sharing mechanism, that fully utilizes resources within a streaming multiprocessor by exploiting heterogeneity of different kernels. We propose several resource allocation strategies to improve system throughput while maintaining fairness. Our evaluation shows that for shared workloads with complementary resource occupancy, SMK improves GPU throughput by 52% over non-shared execution and 17% over a state-of-the-art design.
Information-theoretic measures for anomaly detection (2002)

Anomaly detection is an essential component of protection mechanisms against novel attacks. We propose to use several information-theoretic measures, namely, entropy, conditional entropy, relative conditional entropy, information gain, and information cost for anomaly detection. These measures can be used to describe the characteristics of an audit data set, suggest the appropriate anomaly detection model(s) to be built, and explain the performance of the model(s). We use case studies on Unix system call data, BSM data, and network tcpdump data to illustrate the utilities of these measures.
Neuropathological background of phenotypical variability in frontotemporal dementia (2011)

Frontotemporal lobar degeneration (FTLD) is the umbrella term encompassing a heterogeneous group of pathological disorders. With recent discoveries, the FTLDs have been show to classify nicely into three main groups based on the major protein deposited in the brain: FTLD-tau, FTLD-TDP and FTLD-FUS. These pathological groups, and their specific pathologies, underlie a number of well-defined clinical syndromes, including three frontotemporal dementia (FTD) variants [behavioral variant frontotemporal dementia (bvFTD), progressive non-fluent aphasia, and semantic dementia (SD)], progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS). Understanding the neuropathological background of the phenotypic variability in FTD, PSPS and CBS requires large clinicopathological studies. We review current knowledge on the relationship between the FTLD pathologies and clinical syndromes, and pool data from a number of large clinicopathological studies that collectively provide data on 544 cases. Strong relationships were identified as follows: FTD with motor neuron disease and FTLD-TDP; SD and FTLD-TDP; PSPS and FTLD-tau; and CBS and FTLD-tau. However, the relationship between some of these clinical diagnoses and specific pathologies is not so clear cut. In addition, the clinical diagnosis of bvFTD does not have a strong relationship to any FTLD subtype or specific pathology and therefore remains a diagnostic challenge. Some evidence suggests improved clinicopathological association of bvFTD by further refining clinical characteristics. Unlike FTLD-tau and FTLD-TDP, FTLD-FUS has been less well characterized, with only 69 cases reported. However, there appears to be some associations between clinical phenotypes and FTLD-FUS pathologies. Clinical diagnosis is therefore promising in predicting molecular pathology.
Ethics for tax practitioners (1993)

This project was commissioned by the Australian Tax Research Foundation. Its object is to discuss the issues in relation to the terms of references #1 and #2 of the National Review of Standards for the Tax Profession.
Preparation of fibrin glue from single-donor fresh-frozen plasma. (1985)

Fibrin glue is used widely in Europe as a tissue sealant and hemostatic agent. The European glue is prepared commercially from pooled human blood. It is not available in this country because of the risk of transmission of hepatitis B, acquired immune deficiency syndrome, and other blood-transmitted diseases. We describe a cryoprecipitation technique for preparation of fibrin glue from single-donor fresh-frozen plasma. This technique enables the glue to be made in large quantities with no greater risk of disease transmission than with that from the transfusion of single-unit fresh-frozen plasma. We have found that the glue is a useful tool in surgery. By helping to control difficult bleeding, its use can decrease the need for blood transfusions and shorten operating room time. It also is effective as a means to pretreat highly porous vascular prostheses that currently are used infrequently because of bleeding. These porous grafts offer potential advantages in handling, suturing, and long-term patency. This new technique of fibrin glue preparation may make this useful surgical adjunct as readily available in this country as it is in Europe.