gebhart/patrepeval huggingface dataset:
Post-Crisis Financial Developments in Korea:Implications for Monetary Policy (2003)

A rapid macroeconomic turnaround and lingering financial market uncertainties since the Asian Economic Crisis of 1997 are seen as conflicting but consistent indicators of the fundamental weakness still existent in Korea’s financial markets. Drastic changes in firms &amp;apos; financing strategy, volatile capital movements, and loose financial supervision are some of the examples of inappropriately applied macro measures to a market not yet fully normalized. Given the important role a robust financial sector plays in a developing economy and the limited role of the banking sector in bringing forth a mature market, the missing link for engendering economic efficiency and financial stability in Korea is seen as the absence of a long-term capital market. Heavier reliance on poorly supervised capital markets in the wake of the crisis exaggerated the business cycle and caused a sense of complacency that thwarted institutional reform. As the overall financial market anomalies found posterior to the crisis are due to the lack of market support, future macro polic ies need to focus particularly on promoting a deeper and broader financial market. Furthermore, poor risk evaluations and currency and maturity mismatch problems need to be resolved through the s trengthening of market mechanisms.
Inhibition of Glycogen Synthase Kinase 3β During Heart Failure Is Protective (2007)

Glycogen synthase kinase (GSK)-3, a negative regulator of cardiac hypertrophy, is inactivated in failing hearts. To examine the histopathological and functional consequence of the persistent inhibition of GSK-3beta in the heart in vivo, we generated transgenic mice with cardiac-specific overexpression of dominant negative GSK-3beta (Tg-GSK-3beta-DN) and tetracycline-regulatable wild-type GSK-3beta. GSK-3beta-DN significantly reduced the kinase activity of endogenous GSK-3beta, inhibited phosphorylation of eukaryotic translation initiation factor 2B epsilon, and induced accumulation of beta-catenin and myeloid cell leukemia-1, confirming that GSK-3beta-DN acts as a dominant negative in vivo. Tg-GSK-3beta-DN exhibited concentric hypertrophy at baseline, accompanied by upregulation of the alpha-myosin heavy chain gene and increases in cardiac function, as evidenced by a significantly greater Emax after dobutamine infusion and percentage of contraction in isolated cardiac myocytes, indicating that inhibition of GSK-3beta induces well-compensated hypertrophy. Although transverse aortic constriction induced a similar increase in hypertrophy in both Tg-GSK-3beta-DN and nontransgenic mice, Tg-GSK-3beta-DN exhibited better left ventricular function and less fibrosis and apoptosis than nontransgenic mice. Induction of the GSK-3beta transgene in tetracycline-regulatable wild-type GSK-3beta mice induced left ventricular dysfunction and premature death, accompanied by increases in apoptosis and fibrosis. Overexpression of GSK-3beta-DN in cardiac myocytes inhibited tumor necrosis factor-alpha-induced apoptosis, and the antiapoptotic effect of GSK-3beta-DN was abrogated in the absence of myeloid cell leukemia-1. These results suggest that persistent inhibition of GSK-3beta induces compensatory hypertrophy, inhibits apoptosis and fibrosis, and increases cardiac contractility and that the antiapoptotic effect of GSK-3beta inhibition is mediated by myeloid cell leukemia-1. Thus, downregulation of GSK-3beta during heart failure could be compensatory.
Species-specific difference in distribution of voltage-gated L-type Ca2+ channels of cardiac myocytes (2000)

Ca(2+) influx via sarcolemmal voltage-dependent Ca(2+) channels (L-type Ca(2+) channels) is the fundamental step in excitation-contraction (E-C) coupling in cardiac myocytes. Physiological and pharmacological studies reveal species-specific differences in E-C coupling resulting from a difference in the contribution of Ca(2+) influx and intracellular Ca(2+) release to activation of contraction. We investigated the distribution of L-type Ca(2+) channels in isolated cardiac myocytes from rabbit and rat ventricle by correlative immunoconfocal and immunogold electron microscopy. Immunofluorescence labeling revealed discrete spots in the surface plasma membrane and transverse (T) tubules in rabbit myocytes. In rat myocytes, labeling appeared more intense in T tubules than in the surface sarcolemma. Immunogold electron microscopy extended these findings, showing that the number of gold particles in the surface plasma membrane was significantly higher in rabbit than rat myocytes. In rabbit myocyte plasma membrane, the gold particles were distributed as clusters in both regions that were associated with junctional sarcoplasmic reticulum and those that were not. The findings are consistent with the idea that influx of Ca(2+) via surface sarcolemmal Ca(2+) channels contributes to intracellular Ca(2+) to a greater degree in rabbit than in rat myocytes.
Increased angiogenin expression in the tumor tissue and serum of urothelial carcinoma patients is related to disease progression and recurrence (1999)

BACKGROUND The progression of solid tumors is at least partly dependent on angiogenesis, the induction of which is mediated by several angiogenic factors, including angiogenin (ANG). The authors evaluated the expression of ANG in the tumor tissue and serum of patients with urothelial carcinoma. METHODS The expression of ANG in 5 human bladder carcinoma cell lines and 24 urothelial carcinomas (10 superficial carcinomas and 14 invasive carcinomas) and in corresponding normal urothelial tissues was investigated by reverse transcriptase-polymerase chain reaction and Northern blot analysis. Serum levels of ANG in 52 healthy volunteers and in 135 patients with urothelial carcinomas (81 superficial carcinomas and 54 invasive carcinomas) were measured by using a sandwich enzyme immunoassay. RESULTS ANG mRNA transcripts were detected in all of the bladder carcinoma cell lines, urothelial carcinomas, and normal tissues. The mean level of ANG expression in invasive urothelial carcinomas was 4-fold higher than in superficial carcinomas and 5-fold higher than in normal tissues. The mean serum ANG concentration for invasive urothelial carcinoma patients (514.6 ± 211.1 ng/mL) was significantly higher than for superficial urothelial carcinoma patients (381.7 ± 169.3 ng/mL) and healthy volunteers (337.5 ± 71.4 ng/mL). The overall survival rate of patients with elevated serum levels of ANG was significantly lower than that of patients with normal levels. Moreover, among the 47 patients with advanced urothelial carcinoma who underwent complete resection, the disease free survival rate of patients with elevated serum levels of ANG was significantly lower than that of patients with normal levels. CONCLUSIONS These results indicate that ANG is strongly expressed in the tumor tissue and is present in high levels in the serum of patients with invasive urothelial carcinoma compared with superficial carcinoma patients and that elevation of serum ANG level could be used as a novel predictor of the prognoses of patients with urothelial carcinoma. Cancer 1999;86:316–24. © 1999 American Cancer Society.
[Significance of priming of hosts with virus in the tumor-specific immunotherapy model utilizing virus-reactive helper T cell activity]. (1989)

A tumor-specific immunotherapy model was established utilizing vaccinia virus (VV) in the consideration of clinical application, in which we assessed the significance of priming of hosts with VV to induce in vivo anti-tumor immunity. C3H/HeN mice were pretreated with cyclophosphamide (Cy) to eliminate non-specific suppressor T cell activity and subsequently inoculated (primed) subcutaneously (s.c.) with 10(7)PFU of VV, leading to augmented induction of VV-reactive helper T (VV-Th) cell activities. Four weeks later, the mice were inoculated intradermally (i.d.) with syngeneic X5563 myeloma cells. Six days after the tumor cell inoculation, 5 X 10(7)PFU of VV was injected into the tumor mass 3 times at 2-day intervals. Seven of 10 mice which had received VV-priming and subsequent VV-injection into the tumor mass exhibited complete tumor regression. On the contrary, mice which had received mere intratumoral VV-injection in the absence of VV-priming failed to exhibit appreciable tumor regression. Mice (regressor mice) whose tumor had completely regressed by the above VV-immunotherapy were shown to have acquired systemic anti-tumor immunity which was confirmed by a challenge with syngeneic tumor cells after the tumor regression. In vitro analysis of these immune mice revealed that potent tumor-specific cytotoxic T lymphocyte (CTL) responses were preferentially induced, but with no detectable anti-tumor antibody responses. Such a potent tumor specific immunity was not observed in mice which had received intratumoral VV-injection in the absence of VV-priming.(ABSTRACT TRUNCATED AT 250 WORDS)
Bertolt Brecht, lo nuevo y lo viejo (1999)

Patients with mild to moderate hypertension require only a simple schedule of investigations, especially if there is a history of stroke or hypertension in first degree relatives. Tests are necessary to profile other cardiovascular risk factors and to detect target organ damage with only limited screening for secondary hypertension. Careful history, physical examination, repeated blood pressure measurements over months and measurements of body mass index, random cholesterol, routine blood chemistry and urinalysis using impregnated paper strips are all that are required. More detailed investigations can be reserved for special groups such as those with peripheral vascular disease or abnormal renal function before or after treatment with angiotensin converting enzyme inhibitors or significant proteinuria or hypokalaemia. Patients with essential hypertension who are smokers with lipid abnormalities may go on to develop superimposed renovascular disease. Severe hypertension at any age and especially if there is a reliable negative family history also merits special consideration. Resistance to antihypertensive treatment is more often due to non-compliance or non-steroidal anti-inflammatory drug use or alcohol abuse than to underlying secondary causes.
Induction and Suppression of Collagen-Induced Arthritis Is Dependent on Distinct Fcγ Receptors (2000)

Receptors for immunoglobulin (Ig)G (FcgammaRs) are important for the antibody-mediated effector functions of the immune system. FcgammaRI and FcgammaRIII trigger cell activation through a common gamma chain, whereas FcgammaRII acts as a negative regulator of antibody production and immune complex-triggered activation. Here we describe the in vivo consequences of FcgammaR deficiency in a mouse model of human rheumatoid arthritis. FcRgamma chain-deficient mice on arthritis-susceptible DBA/1 background were immunized with collagen for induction of collagen-induced arthritis. The DBA/1 mice lacking FcRgamma chain were protected from collagen-induced arthritis in contrast to wild-type mice, although both groups produced similar levels of IgG anticollagen antibodies. In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis.
Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro. (1993)

A murine retrovirus-infected human T-cell line, HPB-Ma, supported replication of hepatitis C virus (HCV) at least as well as the previously reported Molt4-Ma cells. Cloning of HPB-Ma cells revealed a clonal variation of cellular susceptibility to HCV infection. Using one of the sensitive clones, we tested HCV inocula from different sources for their infectivity titer in cell culture. The in vitro titers obtained correlated with the reported infectivity titers of the inocula in chimpanzees. Thus, the system appears to be useful for estimating the in vivo infectivity of HCV.
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. (1987)

One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycoprotein-toxin conjugates specifically kill multidrug-resistant human KB cells. Similar conjugates could be useful in cancer therapy to reduce or eliminate multidrug-resistant tumor populations in tumors intrinsically resistant to chemotherapy or in populations that become resistant during combination chemotherapy.
BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities (2006)

BindingDB (http://www.bindingdb.org) is a publicly accessible database currently containing approximately 20,000 experimentally determined binding affinities of protein-ligand complexes, for 110 protein targets including isoforms and mutational variants, and approximately 11,000 small molecule ligands. The data are extracted from the scientific literature, data collection focusing on proteins that are drug-targets or candidate drug-targets and for which structural data are present in the Protein Data Bank. The BindingDB website supports a range of query types, including searches by chemical structure, substructure and similarity; protein sequence; ligand and protein names; affinity ranges and molecular weight. Data sets generated by BindingDB queries can be downloaded in the form of annotated SDfiles for further analysis, or used as the basis for virtual screening of a compound database uploaded by the user. The data in BindingDB are linked both to structural data in the PDB via PDB IDs and chemical and sequence searches, and to the literature in PubMed via PubMed IDs.
Thiopurine methyltransferase: a review and a clinical pilot study. (1996)

Thiopurine methyltransferase (TPMT) is an important enzyme in the metabolism of 6-mercaptopurine (6MP), which is used in the treatment of acute lymphoblastic leukemia (ALL). TPMT catalyzes the formation of methylthioinosine monophosphate (MetIMP), which is cytotoxic for cultured cell lines, and it plays a role in detoxification of 6MP. Population studies show a genetic polymorphism for TPMT with both high and low activity alleles. About 1 of 300 subjects is homozygous for the low activity. The function TPMT plays in detoxification or therapeutic efficacy of 6MP in vivo is not clear. In this article the genetic polymorphism of TPMT is reviewed and the contribution of TPMT to the cytotoxic action, or detoxification, of 6MP in children with ALL is discussed. Induction of TPMT activity has been described during the treatment for ALL. We performed a pilot study on the influence of high-dose 6MP infusions (1300 mg/m2 in 24 h) on TPMT activity of peripheral blood mononuclear cells (pMNC) of eleven patients with ALL. The TPMT activities were in, or, above the normal range. There was no statistically significant difference between the TPMT activities before and after the 6MP infusions. MetIMP levels in pMNC increased during successive courses. This might be explained by TPMT induction, but other explanations are plausible as well. Twenty five percent of the TPMT assays failed, because less than the necessary 5.10(6) pMNC could be isolated from the blood of leukopenic patients. Red blood cells can not be used for TPMT measurements, since transfusions are frequently required during the treatment with 6MP infusions. Therefore, the influence of high-dose 6MP infusions on TPMT activity can only be investigated further when a TPMT assay which requires less pMNC has been developed.
Imaging Biomarkers in Atherosclerosis Trials (2011)

Advantages and Disadvantages Coronary angiography Coronary lumen 0.4 mm Yes Yes Two-dimensional silhouette of lumen only, associated with cardiovascular events, accepted surrogate for expanded indication IVUS Coronary arterial wall 0.08-0.10mm No Yes, catheter Tomographic, volumetric assessment of changes in plaque burden and vascular remodeling with excellent resolution Carotid ultrasound cIMT and plaque 0.15 mm No No Wide availability, wide clinical trial experience, low cost, technically demanding; further validation of 3D plaque assessment required Coronary CT Coronary lumen and wall 0.4 mm Yes No Rapid acquisition, limited image resolution for plaque burden, radiation exposure MRI Carotid lumen and wall 0.5-1.0mm No No Plaque characterization possible, no validation with clinical events PET Metabolic activity in carotids and aorta 4 mm Yes No Limited image resolution, limited ability to visualize coronary arteries, no validation with clinical events OCT Coronary arterial lumen and wall Excellent, 0.01 mm No Yes, catheter Best image resolution, limited depth of view Requires flushing of lumen NIRS Tissue spectral contrast (chemical assessment) 1 mm No Yes, catheter Link to plaque status not clear, images difficult to interpret, limited spatial registration NIR fluorescence Exogenous, molecular contrast 1 mm No Yes, catheter and injection of molecular compound Limited depth of view due to blood absorption, may require flushing; high potential for molecular imaging; depends on targeted compound approval for humans
Extension of the reconstruction field of view and truncation correction using sinogram decomposition (2007)

We propose a novel truncation correction algorithm that completes unmeasured data outside of the scan field of view, which allows extending the reconstruction field of view. When a patient extends outside the detector coverage the projection data are transversely truncated, which causes severe artifacts. The proposed method utilizes the idea of sinogram decomposition, where we consider sinogram curves corresponding to image points outside the field of view. We propose two ways to estimate the truncated data, one based on the minimum value along the sinogram curve, and the other based on the data values near the edge of truncation. Both estimation methods are combined to achieve uniform image quality improvement from the edge of truncation to the outer side of the extended region. In our evaluation with simulated and real projection data we compare the proposed method with existing methods and investigate the dependence on the amount of truncation. The evaluation shows that the proposed method handles cases when truncation is present on both sides of the detector, or when a high-contrast object is located outside the field of view.
A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism (2007)

This is the first report of DC101-induced antitumor immune responses. It establishes the induction of tumor-specific T-cell responses as one consequence of VEGF-R2 targeting with DC101. These data support the development of multitargeted cancer therapy combining immune-based and antiangiogenic agents for clinical translation.
Influence of surface stress on the resonance behavior of microcantilevers (2005)

This work presents a model to predict the effect of surface stresses on the ith-mode bending resonant frequency of microcantilevers and its experimental validation. With this model, one can calculate the surface stress acting upon the microcantilever solely by measuring resonant frequencies whereas previously one needed to measure the deflection. Resonant frequency measurement has distinct advantages in terms of ease and accuracy of measurement.
A Subband Feedback Controlled Generalized Sidelobe Canceller in Frequency Domain with Multi-Channel Postfilter (2010)

In this paper, a speech enhancement algorithm based on microphone array which features the interaction between adaptive beamforming and multi-channel postfilter is proposed.A subband feedback controller based on speech presence probability is applied to Generalized Sidelobe Canceller algorithm to obtain a more robust adaptive filter in adverse environment and alleviate the problem of signal cancellation in adaptive beamformer. A multi-channel postfilter is used not only to further suppress diffused noise and interferences, but also to give the speech presence probability information in each subband. This approach achieves considerable improvement on noise reduction and subjective quality of the desired speech compared with Griffiths-Jim beamformer with Weiner postfilter. Experiments confirm the effectiveness of the proposed algorithm.
Evidence for a Regulated Interaction between Heterotrimeric G Proteins and Caveolin (1995)

Caveolae are flask-shaped plasma membrane specializations. A 22-kDa protein, caveolin, is a principal component of caveolar membranes in vivo. As recent evidence suggests that caveolae may participate in G protein-coupled signaling events, we have investigated the potential interaction of caveolin with heterotrimeric G proteins. Using cell fractionation techniques, we found that mutational or pharmacologic activation of Gs alpha prevents its cofractionation with caveolin. In a second independent approach, we directly examined the interaction of G proteins with caveolin. For this purpose, we recombinantly expressed caveolin as a glutathione S-transferase fusion protein. Using an in vitro binding assay, we found that caveolin interacts with G protein alpha subunits (Gs, Go, and Gi). Mutational or pharmacologic activation (with guanosine 5'-O-(thiotriphosphate)) of G alpha subunits prevents this interaction, indicating that the inactive GDP-bound form of G alpha subunits preferentially interacts with caveolin. This G protein binding activity is located within a 41-amino acid region of caveolin's cytoplasmic N-terminal domain (residues 61-101). Further functional analysis shows that a polypeptide derived from this region of caveolin (residues 82-101) effectively suppresses the basal activity of purified G proteins, apparently by inhibiting GDP/GTP exchange. This caveolin sequence is homologous to a region of the Rab GDP dissociation inhibitor, a known inhibitor of GDP/GTP exchange for Rab proteins. These data suggest that caveolin could function to negatively regulate the activation state of heterotrimeric G proteins.
Random Laser Action in Semiconductor Powder (1999)

We report the first observation of random laser action with coherent feedback in semiconductor powder. Since the scattering mean free path is less than the emission wavelength, recurrent light scattering arises and provides coherent feedback for lasing. Discrete lasing modes have been observed above the threshold. The dependence of the lasing threshold intensity on the excitation volume agrees with the random laser theory. Laser emission from the powder could be observed in all directions. This observation also provides direct evidence for the existence of recurrent scattering of light.
Learning semantic representations using convolutional neural networks for web search (2014)

This paper presents a series of new latent semantic models based on a convolutional neural network (CNN) to learn low-dimensional semantic vectors for search queries and Web documents. By using the convolution-max pooling operation, local contextual information at the word n-gram level is modeled first. Then, salient local fea-tures in a word sequence are combined to form a global feature vector. Finally, the high-level semantic information of the word sequence is extracted to form a global vector representation. The proposed models are trained on clickthrough data by maximizing the conditional likelihood of clicked documents given a query, us-ing stochastic gradient ascent. The new models are evaluated on a Web document ranking task using a large-scale, real-world data set. Results show that our model significantly outperforms other se-mantic models, which were state-of-the-art in retrieval performance prior to this work.