gebhart/patrepeval huggingface dataset:
Gain modulation by graphene plasmons in aperiodic lattice lasers (2016)

Two-dimensional graphene plasmon-based technologies will enable the development of fast, compact, and inexpensive active photonic elements because, unlike plasmons in other materials, graphene plasmons can be tuned via the doping level. Such tuning is harnessed within terahertz quantum cascade lasers to reversibly alter their emission. This is achieved in two key steps: first, by exciting graphene plasmons within an aperiodic lattice laser and, second, by engineering photon lifetimes, linking graphene's Fermi energy with the round-trip gain. Modal gain and hence laser spectra are highly sensitive to the doping of an integrated, electrically controllable, graphene layer. Demonstration of the integrated graphene plasmon laser principle lays the foundation for a new generation of active, programmable plasmonic metamaterials with major implications across photonics, material sciences, and nanotechnology.
Self-Assembly of Uniform Monolayer Arrays of Nanoparticles (2003)

Five nanometer diameter gold particles encapsulated by alkanethiol molecules have been self-assembled into well-ordered monolayers on a water surface, and these nanoparticle films have been transferred intact onto various solid substrates. The method involves spreading a thin layer of an organic solvent containing the gold nanoparticles on a water subphase that has a controlled surface curvature. As the solvent evaporates, a nanoparticle monolayer free of microscopic cracks and voids nucleates at the center of the apparatus and grows radially outward until it covers practically the entire water surface. This monolayer is transferred from the water surface to a polydimethylsiloxane (PDMS) stamp pad by the Langmuir-Schaefer (LS) technique and is applied to the solid substrate by microcontact printing (μCP). Uniform centimeter-scale films have been produced with this method. The quality of the transferred films has been verified by transmission electron microscopy (TEM). The nanoparticle monolayer is a hexagonal close-packed array with a center-to-center spacing that is approximately equal to the sum of the diameter of the gold particles and twice the height of a self-assembled monolayer (SAM) of the alkanethiol molecules on Au(111). The transferred films are free of multilayer regions and of microscopic voids and grain boundaries over their entire area and exhibit crystalline order across the openings in the TEM grid (∼4000 μm<sup>2</sup>).
Switching dynamics of suspended mesogenic polymer microspheres (2001)

Ordered polymer microspheres were produced by photo-polymerizing reactive nematic liquid crystal droplets suspended in glycerol, thus capturing the mesogenic order indefinitely. The electro-optic switching of these structures suspended in a fluid is investigated and described by a simple phenomenological model.
Performance evaluation of mutal overflow routing for hierarchical packet‐switching networks (1988)

Abstract This paper presents an evaluation of the traffic characteristics of the overflow routing, which is one of the isolated routings (i.e., only the information in the switching station is utilized) of the packet‐switching network. In the overflow routing, the packet selects the first route if the number of waiting packets in the first route is less than the threshold value, and selects the second route if it is equal to or larger than the threshold. Which of the routes is defined as the first route is determined for each destination of the packet, and the packet deroutes others among the routes. In the first part of this paper, the relation between the transmission‐waiting time in the switching station and the threshold of the overflow routing is derived. Then the two‐level hierarchical packet‐switching network is considered, and the mutual overflow routing, SQ + B routing and the stochastic routing, which is easy to realize with simple processing, are compared from the viewpoint of the transmission delay between the transmitting and receiving stations; SQ + B routing has the best performance in the isolated routings, and the stochastic routing features in the simple processing and the easy representation. As a result, it is shown that the transmission delay in the mutual overflow routing is less than in the stochastic routing and is nearly the same as that of SQ + B routing. Since the processing per packet in the mutual overflow routing is less than that of the SQ + B routing, the mutual overflow routing can be considered as the best among the three routing methods.
Docking of 4-oxalocrotonate tautomerase substrates: Implications for the catalytic mechanism (1999)

The enzyme 4-oxalocrotonate tautomerase catalyzes the ketonization of dienols, which after further processing become intermediates in the Krebs cycle. The enzyme uses a general acid-base mechanism for proton transfer: the amino-terminal proline has been shown to function as the catalytic base and Arg39 has been implicated as the catalytic acid. We report the results of molecular docking simulations of 4-oxalocrotonate tautomerase with two substrates, 2-hydroxymuconate and 5-carboxymethyl-2-hydroxymuconate. pKa calculations are also performed for the free enzyme. The predicted binding mode of 2-hydroxymuconate is in agreement with experimental data. A model for the binding mode of 5-carboxymethyl-2-hydroxymuconate is proposed which explains the lower catalytic efficiency of the enzyme toward this substrate. The pKa predictions and docking simulations support residue Arg39 as the general acid for the enzyme catalysis.
An In Vivo Evaluation of Docetaxel Delivered Intratumorally in Head and Neck Squamous Cell Carcinoma (2005)

Injections of IT docetaxel at usual and supradoses are associated with a pharmacokinetic profile and biological mechanism distinct from those observed with usual IV doses. It is calculated that IT therapy in men will increase peak concentrations of docetaxel in tumors by 1000-fold over the conventional IV dose used clinically. These preclinical results support further testing of IT docetaxel in HNSCC.
A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes (1995)

We previously reported the cloning of a serine/threonine kinase, PAK (for p21 (Cdc42/Rac)-activated kinase), which binds to the Ras-related GTPases Cdc42Hs and Rac1 (Manser, E., Leung, T., Salihuddin, H., Zhao, Z-s., and Lim, L. (1994) Nature 367, 40-46). These p21 proteins together with RhoA comprise the Rho subfamily of proteins that are involved in morphological events. We now report the isolation of a rat cDNA encoding a 150-kDa protein, which specifically binds RhoA in its GTP form and contains an N-terminal serine/threonine kinase domain highly related to the human myotonic dystrophy kinase and a cysteine-rich domain toward the C terminus. The RhoA binding domain is unrelated to other p21 binding domains. Antibody raised against the kinase domain of the predicted protein, termed ROK alpha (for ROK alpha, RhoA-binding kinase), recognized a ubiquitous 150-kDa protein. The brain p150 purified by affinity chromatography with RhoA exhibited serine/threonine kinase activity. In cultured cells, immunoreactive p150 was recruited to membranes upon transfection with dominant positive RhoAV14 mutant and was localized with actin microfilaments at the cell periphery. These results are consistent with a role for the kinase ROK alpha as an effector for RhoA.
Atomic Layer Deposition of Metal Oxides on Pristine and Functionalized Graphene (2008)

We investigate atomic layer deposition (ALD) of metal oxide on pristine and functionalized graphene. On pristine graphene, ALD coating can only actively grow on edges and defect sites, where dangling bonds or surface groups react with ALD precursors. This affords a simple method to decorate and probe single defect sites in graphene planes. We used perylene tetracarboxylic acid (PTCA) to functionalize the graphene surface and selectively introduced densely packed surface groups on graphene. Uniform ultrathin ALD coating on PTCA graphene was achieved over a large area. The functionalization method could be used to integrate ultrathin high-kappa dielectrics in future graphene electronics.
Molecular characterization of SerH3, a Tetrahymena thermophila gene encoding a temperature-regulated surface antigen. (1990)

The DNA sequences of a cDNA clone and the macronuclear genomic fragment corresponding to the functional copy of the SerH3 surface antigen gene of Tetrahymena thermophila were determined. Primer extension and nuclease protection assays show that the SerH3 transcription unit is 1,425 nucleotides long and contains no introns. The predicted polypeptide encoded by the SerH3 gene has a molecular mass of 44,415 daltons; one-third of its 439 residues are either cysteine, serine, or threonine. The central half of the polypeptide consists of three homologous domains in tandem array; within these domains, the cysteine, proline, and tryptophan residues occur in highly regular patterns.
Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity (1987)

Glutamic acid 553 of Pseudomonas aeruginosa exotoxin A (ETA) has been identified by photoaffinity labeling as a residue within the NAD binding site (S.F. Carroll and R.J. Collier, J. Biol. Chem. 262:8707-8711, 1987). To explore the function of Glu-553 we used oligonucleotide-directed mutagenesis to replace this residue with Asp in cloned ETA and expressed the mutant gene in Escherichia coli K-12. ADP-ribosylation activity of Asp-553 ETA in cell extracts was about 1,800-fold lower and toxicity for mouse L-M929 fibroblasts was at least 10,000-fold lower than that of the wild-type toxin. Extracts containing Asp-553 ETA inhibited the cytotoxicity of authentic ETA on L-M929 fibroblasts, suggesting that the mutant toxin competes for ETA receptors. The results indicate that Glu-553 is crucial for ADP-ribosylation activity and, consequently, cytotoxicity of ETA. Substitution or deletion of this residue may be a route to new ETA vaccines.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells (2004)

In order to analyze differential gene expression of putative prostate tumor markers we compared the expression levels of >400 cancer-related genes using the cDNA array technique in a set of prostate tumors and matched normal prostate tissues. Up-regulated expression of mammary tumor 8 kDa protein (MAT-8), complement component C1S (C1S), ferritin heavy chain (FTH1), peptidyl-prolyl cis-trans isomerase A (PPIA), RNA-binding protein regulatory subunit DJ-1 protein (DJ-1) and vacuolar ATP synthase subunit F (ATP6V1F) was determined in prostate carcinoma and confirmed by using quantitative real-time RT-PCR analyses. Furthermore, quantitative real time RT-PCR on intact RNAs from 11 paired laser microdissected epithelial tissue samples confirmed up-regulated MAT-8 expression in 6 out of 11 prostate tumors. To determine the function of MAT-8 in vitro, human PC-3 and LNCaP prostate carcinoma cells were transfected with small interfering double-stranded RNA (siRNA) oligonucleotides against the MAT-8 gene leading to a specific down-regulation of MAT-8 expression. In addition, suppression of MAT-8 expression caused a significant decrease in cellular proliferation of both prostate cancer cell lines, whereas invasive capacity and cellular apoptosis remained unaffected. Taken together, our results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas.
A Gaussian Prior for Smoothing Maximum Entropy Models (1999)

Abstract : In certain contexts, maximum entropy (ME) modeling can be viewed as maximum likelihood training for exponential models, and like other maximum likelihood methods is prone to overfitting of training data. Several smoothing methods for maximum entropy models have been proposed to address this problem, but previous results do not make it clear how these smoothing methods compare with smoothing methods for other types of related models. In this work, we survey previous work in maximum entropy smoothing and compare the performance of several of these algorithms with conventional techniques for smoothing n-gram language models. Because of the mature body of research in n-gram model smoothing and the close connection between maximum entropy and conventional n-gram models, this domain is well-suited to gauge the performance of maximum entropy smoothing methods. Over a large number of data sets, we find that an ME smoothing method proposed to us by Lafferty performs as well as or better than all other algorithms under consideration. This general and efficient method involves using a Gaussian prior on the parameters of the model and selecting maximum a posteriori instead of maximum likelihood parameter values. We contrast this method with previous n-gram smoothing methods to explain its superior performance.
Combined Treatment with a BACE Inhibitor and Anti-Aβ Antibody Gantenerumab Enhances Amyloid Reduction in APPLondonMice (2014)

Therapeutic approaches for prevention or reduction of amyloidosis are currently a main objective in basic and clinical research on Alzheimer's disease. Among the agents explored in clinical trials are anti-Aβ peptide antibodies and secretase inhibitors. Most anti-Aβ antibodies are considered to act via inhibition of amyloidosis and enhanced clearance of existing amyloid, although secretase inhibitors reduce the de novo production of Aβ. Limited information is currently available on the efficacy and potential advantages of combinatorial antiamyloid treatment. We performed a chronic study in APPLondon transgenic mice that received treatment with anti-Aβ antibody gantenerumab and BACE inhibitor RO5508887, either as mono- or combination treatment. Treatment aimed to evaluate efficacy on amyloid progression, similar to preexisting amyloidosis as present in Alzheimer's disease patients. Mono-treatments with either compound caused a dose-dependent reduction of total brain Aβ and amyloid burden. Combination treatment with both compounds significantly enhanced the antiamyloid effect. The observed combination effect was most pronounced for lowering of amyloid plaque load and plaque number, which suggests effective inhibition of de novo plaque formation. Moreover, significantly enhanced clearance of pre-existing amyloid plaques was observed when gantenerumab was coadministered with RO5508887. BACE inhibition led to a significant time- and dose-dependent decrease in CSF Aβ, which was not observed for gantenerumab treatment. Our results demonstrate that combining these two antiamyloid agents enhances overall efficacy and suggests that combination treatments may be of clinical relevance.
In vitro susceptibility of Clostridium difficile to new beta-lactam and quinolone antibiotics (1985)

The in vitro susceptibilities of 34 to 73 clinical isolates of Clostridium difficile to 24 antimicrobial agents, including 18 beta-lactams, 4 fluoroquinolones, clindamycin, and metronidazole were examined. Metronidazole was the most active (MIC for 90% of the isolates [MIC90], 0.5 microgram/ml), followed by the carbapenems (Sch 34343, 4 micrograms/ml; imipenem, 8 micrograms/ml) and the antipseudomonas penicillins (piperacillin, 8 micrograms/ml; ticarcillin, 32 micrograms/ml; carbenicillin, 32 micrograms/ml). A monobactam (aztreonam) and most cephalosporins were either highly inactive (cefoxitin, cefuroxime, cefotiam, cefsulodin, ceftizoxime, cefbuperazone, and cefotaxime), with an MIC90 of greater than or equal to 128 micrograms/ml, or moderately inactive (ceftriaxone, cefmenoxime, cefoperazone, ceftazidime, and moxalactam), with an MIC90 of greater than or equal to 32 micrograms/ml. Clindamycin (MIC90, 32 micrograms/ml) and the fluoroquinolones (ciprofloxacin, 8 micrograms/ml; A-56619, 8 micrograms/ml; A-56620, 8 micrograms/ml; norfloxacin, 32 micrograms/ml) were only variably active. These in vitro data per se may not necessarily predict the relative risks for C. difficile-associated diarrhea or colitis during therapy with these agents. However, these data, in concert with knowledge of drug bioavailability in feces and the broad-spectrum antimicrobial activity on the resident bowel flora, may provide additional insight into the mechanisms and predictability of this complication with these agents. Careful monitoring for the emergence of C. difficile and fecal cytotoxin and for diarrhea during therapy with these agents is clearly indicated.
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice (2005)

Our data provide evidence for early induction of inflammatory processes in a model that develops amyloid and neurofibrillary tangle pathology. Additionally, our results link inflammatory processes within the entorhinal cortex, which represents one of the earliest AD-affected brain regions.
Dihexylquaterthiophene, A Two-Dimensional Liquid Crystal-like Organic Semiconductor with High Transport Properties (1998)

End-substitution of quaterthiophene with hexyl groups leads to a highly soluble conjugated oligomer, α,ω-dihexylquaterthiophene (DH4T), which has been characterized for its thermal, structural, and electrical properties. Differential scanning calorimetry indicates the existence of a 3-dimension (3D)-to-mesophase transition, occurring at 84 °C, below the melting temperature of the material (179 °C). X-ray diffraction patterns performed on crude and thermally treated films of DH4T confirm the existence of a smectic phase with two spacings that increase with temperature. This result is interpreted by a model involving alkyl chain movements, which result in spacing shrinkage, whereas the thienylene sequence remains faced at typical van der Waals distances. DH4T thus forms a 2-dimensional (2D) semiconductor with a liquid crystal-like structural organization. DH4T can be deposited as active semiconducting layer in thin-film transistors, either by vacuum evaporation or by spin coating on an octylsilane-pretreated surface. A high-field-effect carrier mobility has been obtained for both deposition techniques, μ = 3 × 10-2 and 1.2 × 10-2 cm2 V-1 s-1, respectively, together with an interesting Ion/Ioff ratio of 105. These data are discussed together with literature results on unsubstituted quaterthiophene (4T) and the parent sexithiophenes (DH6T and 6T). On one hand, results show that the semiconducting quaterthiophene core in DH4T is large enough to allow high charge transport properties, comparable to those of a sexithiophene core, whereas the core is also short enough to allow its α,ω-dialkylated derivative to be highly soluble and solution processable, contrary to the case of DH6T. Results also suggest that the larger band gap of the shorter conjugated quaterthiophenes is responsible for their lower dopant concentration, and hence of their higher dynamic ratio.
Synthesis of enantiomerically pure diethylenetriaminepentaacetic acid analogs. L-Phenylalanine as the educt for substitution at the central acetic acid (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of enantiomerically pure diethylenetriaminepentaacetic acid analogs. L-Phenylalanine as the educt for substitution at the central acetic acidMatthew A. Williams and Henry RapoportCite this: J. Org. Chem. 1993, 58, 5, 1151–1158Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/jo00057a030https://doi.org/10.1021/jo00057a030research-articleACS PublicationsRequest reuse permissionsArticle Views888Altmetric-Citations83LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of 5-methyl-5H-pyrrolo[2,3-c]quinoline and 4-methyl-4H-pyrrolo[2,3-c]isoquinoline: two new unnatural D-ring stripped isomers of the cryptolepine series (2009)

5-Methyl-5H-pyrrolo[2,3-c]quinoline and 4-methyl-4H-pyrrolo[2,3-c]isoquinoline have been synthesized via a domino condensation -Heck cyclisation of, respectively, 4-bromoquinolin-3amine or 4-bromoisoquinolin-3-amine and acetaldehyde. Selective methylation of the tricyclic skeletons yielded the title compounds 5-methyl-5H-pyrrolo[2,3-c]quinoline and 4-methyl-4Hpyrrolo[2,3-c]isoquinoline.
Wireless data center networking with steered-beam mmWave links (2011)

This paper presents a new type of wireless networking applications in data centers using steered-beam mmWave links. By taking advantage of clean LOS channels on top of server racks, robust wireless packet-switching network can be built. The transmission latency can be reduced by flexibly bridging adjacent rows of racks wirelessly without using long cables and multiple switches. Eliminating cables and switches also reduces equipment costs as well as server installation and reconfiguration costs. Security can be physically enhanced with controlled directivity and negligible wall penetration. The aggregate data transmission BW per given volume is expected to scale as the fourth power of carrier frequency. The paper also deals with the architecture of such network configurations and a preliminary demonstration system.
Whittaker, Thomas (1856–1935) (2004)

Whittaker, Thomas Thomas Whittaker was born in Accrington, Lancashire on 25 September 1856 and died in London on 3 October 1935. He was the son of a consulting engineer. Educated privately and at the Royal College of Science, Dublin, he was a scholar of Exeter College, Oxford (1877–80), where he gai
Memory efficient global scheduling of real-time tasks (2015)

Current computing architectures are commonly built with multiple cores and a single shared main memory. Even though this architecture increases the overall computation power, main memory can easily become a bottleneck. Simultaneous access to main memory from multiple cores can cause both (1) severe degradation in performance and (2) unpredictable execution time for real-time applications. We propose in this paper to mitigate these two problems by co-scheduling cores as well as the main memory for predictable execution. In particular, we use a DMA component to overlap memory with computation for hiding the memory latency and therefore increasing the system performance. The main contribution of this paper is a novel global co-scheduling algorithm along with its associated schedulability analysis for sporadic hard real-time tasks. We evaluated our system by generating synthetic tasksets based on real benchmark parameters. The results show a significant improvement in system utilization while retaining a predictable system behavior.