gebhart/patrepeval huggingface dataset:
Paradoxical Hormone Responses of KPL-1 Breast Cancer Cells in vivo: A Significant Role of Angiogenesis in Tumor Growth (2000)

In our previous study, the growth of KPL-1 human breast cancer cells was found to be stimulated by an antiestrogen, ICI 182, 780, and inhibited by 17 beta-estradiol (E2) in vivo but not in vitro. To investigate the action mechanisms of these paradoxical responses, the effects of E2, ovariectomy (Ovex) and medroxyprogesterone acetate (MPA) on the growth, angiogenesis, apoptosis and expression of vascular endothelial growth factor (VEGF) were investigated. E2 stimulated the growth of KPL-1 cells but MPA inhibited it in vitro. In contrast, E2 propionate inhibited the growth of KPL-1 cells in female nude mice but Ovex and MPA stimulated it. E2 propionate suppressed angiogenesis and increased apoptosis in KPL-1 tumors, but Ovex and MPA promoted angiogenesis and decreased apoptosis. Both mRNA expression and secretion of VEGF were stimulated by MPA in KPL-1 cells, but in E2-dependent ML-20 cells they were both inhibited by MPA. E2 did not significantly influence VEGF expression in either cell line. These findings suggest that the abnormal modulation of VEGF expression by MPA and of the other angiogenic factor by E2 are responsible for the paradoxical growth responses of KPL-1 cells in vivo. To support this hypothesis, an antiangiogenic agent, TNP-470, was administered to mice bearing KPL-1 tumors. TNP-470 significantly inhibited the growth of KPL-1 tumors stimulated by MPA. Antiangiogenic agents may be effective for the treatment of hormone-refractory breast cancer.
Functional analysis of a retroviral host-range mutant: altered long terminal repeat sequences allow expression in embryonal carcinoma cells. (1987)

A retroviral host-range neomycin-resistant myeloproliferative sarcoma virus mutant, which is expressed in the embryonal carcinoma cell lines F9 and PCC4aza1R, was molecularly cloned and analyzed. This mutant virus, PCMV, differs from myeloproliferative sarcoma virus by two major deletions, one of which spans exactly a 75-base-pair repeat of the long terminal repeat. Functional analysis of recombinant viruses shows that the host-range expansion of PCMV is a property of nucleotide changes within the U3 region of the long terminal repeat. Furthermore, expression assays of chimeric long terminal repeats show that the enhancer region of PCMV joined to the promoter region of Moloney murine leukemia virus is sufficient to direct the synthesis of chloramphenicol acetyltransferase in F9 and PCC4 cells.
Clinical utility of nivolumab in the treatment of advanced melanoma (2016)

Melanomas are highly immunogenic tumors that evade the immune system by exploiting innate checkpoint pathways, rendering effector T-cells anergic. The immunotherapeutic approach of checkpoint inhibition can restore and invigorate endogenous antitumor T-cell responses and has become an important treatment option for patients with advanced melanoma. The CTLA-4 inhibitor ipilimumab and the PD-1 inhibitors nivolumab and pembrolizumab have been shown to induce durable responses and improve overall survival in metastatic, refractory melanoma. Optimization and validation of pretreatment biomarkers to predict response to these agents is a crucial area of ongoing research. Combination immunotherapy has recently demonstrated superior response rates compared to monotherapy; further investigation is needed to refine combinatorial strategies.
Effect of grain sizes and shapes on phonon thermal conductivity of bulk thermoelectric materials (2011)

This paper presents a phonon transport model for bulk thermoelectric materials to investigate the effect of the grain sizes and grain shapes on phonon thermal conductivity. An analytical solution for the effective thermal conductivity contributing from the grains and grain boundaries of the bulk thermoelectric material is obtained, and the impact of the grain geometric characteristics on the thermal conductivity is analyzed. The theoretical model exhibits quite a well description on the often experimentally observed grain size-dependent thermal conductivity. Meanwhile it is demonstrated that the grain shapes significantly influence the thermal conductivity, especially for small grain sizes (with dimensionless values ξa&amp;lt;10). An optimal grain shape is achieved that leads to a minimum value of thermal conductivity of the bulk thermoelectric material.
Estimation of Variable-Speed-Drive Power Consumption From Harmonic Content (2005)

Nonintrusive load monitoring can be used to identify the operating schedule of individual loads strictly from measurements of an aggregate power signal. Unfortunately, certain classes of loads present a continuously varying power demand. The power demand of these loads can be difficult to separate from an aggregate measurement. Variable-speed drives (VSDs) are industrially important variable-demand loads that are difficult to track non-intrusively. This paper proposes a VSD power estimation method based on observed correlations between fundamental and higher harmonic spectral content in current. The technique can be generalized to any load with signature correlations in harmonic content, including many power electronic and electromechanical loads. The approach presented here expands the applicability and field reliability of nonintrusive load monitoring.
Handbook of Battery Materials (1998)

I. FUNDAMENTALS AND GENERAL ASPECTS OF ELECTROCHEMICAL ENERGY STORAGE Thermodynamics and Mechanistics Practical Batteries Global Competition of Primary and Secondary Batteries II. MATERIALS FOR AQUEOUS ELECTROLYTE BATTERIES Structural Chemistry of Manganese Dioxide and Related Compounds Electrochemistry of Manganese Oxides Nickel Hydroxides Lead Oxides Bromine-Storage Materials NaS Materials Metallic Negatives Metal Hydride Electrodes Carbons Separators III. MATERIALS FOR ALKALI METAL BATTERIES The Structural Stability of Transition Metal Oxide Insertion Electrodes for Lithium Batteries Overcharge-Protected Oxide Cathodes Rechargeable Lithium Anodes Lithium Alloy Anodes Lithiated Carbons The Anode/Electrode Interface Liquid Nonaqueous Electrolytes Polymer Electrolytes Solid Electrolytes Separators for Lithium-Ion Batteries Materials for High Temperature Batteries IV. PERFORMANCE AND TECHNOLOGY DEVELOPMENT FOR BATTERIES Simulation and Modeling of Battery systems Failure Mechanisms, Mechanical Properties, and Advanced in-situ Characterization Methods Battery Safety Battery Manufacturing and Economic Aspects
Live, Runtime Phase Monitoring and Prediction on Real Systems with Application to Dynamic Power Management (2006)

Computer architecture has experienced a major paradigm shift from focusing only on raw performance to considering power-performance efficiency as the defining factor of the emerging systems. Along with this shift has come increased interest in workload characterization. This interest fuels two closely related areas of research. First, various studies explore the properties of workload variations and develop methods to identify and track different execution behavior, commonly referred to as "phase analysis". Second, a large complementary set of research studies dynamic, on-the-fly system management techniques that can adaptively respond to these differences in application behavior. Both of these lines of work have produced very interesting and widely useful results. Thus far, however, there exists only a weak link between these conceptually related areas, especially for real-system studies. Our work aims to strengthen this link by demonstrating a real-system implementation of a runtime phase predictor that works cooperatively with on-the-fly dynamic management. We describe a fully-functional deployed system that performs accurate phase predictions on running applications. The key insight of our approach is to draw from prior branch predictor designs to create a phase history table that guides predictions. To demonstrate the value of our approach, we implement a prototype system that uses it to guide dynamic voltage and frequency scaling. Our runtime phase prediction methodology achieves above 90% prediction accuracies for many of the experimented benchmarks. For highly variable applications, our approach can reduce mispredictions by more than 6X over commonly-used statistical approaches. Dynamic frequency and voltage scaling, when guided by our runtime phase predictor, achieves energy-delay product improvements as high as 34% for benchmarks with non-negligible variability, on average 7% better than previous methods and 18% better than a baseline unmanaged system
Response to Phenelzine and Amitriptyline in Subtypes of Outpatient Depression (1982)

Outpatients with depression and mixed anxiety-depression were treated for six weeks with phenelzine sulfate, amitriptyline hydrochloride, or placebo in a controlled trial. Both active drugs were superior to placebo and were closely comparable in efficacy. Interactions were examined between drug response and classifications based on three different usages of the term atypical depression: additional anxiety or phobic symptoms, atypical functional shift, and nonendogenous depression. Some additional related classifications were also included. There was a tendency for phenelzine to have stronger effects in patients with additional anxiety and without evidence of chronic characterological depression. However, interactions were relatively few. These findings suggest that the two classes of antidepressant affect similar clinical subgroups within the outpatient depressive spectrum, with only relatively weak differences.
Elastin-like polypeptides as a promising family of genetically-engineered protein based polymers (2014)

Elastin-like polypeptides (ELP) are artificial, genetically encodable biopolymers, belonging to elastomeric proteins, which are widespread in a wide range of living organisms. They are composed of a repeating pentapeptide sequence Val-Pro-Gly-Xaa-Gly, where the guest residue (Xaa) can be any naturally occurring amino acid except proline. These polymers undergo reversible phase transition that can be triggered by various environmental stimuli, such as temperature, pH or ionic strength. This behavior depends greatly on the molecular weight, concentration of ELP in the solution and composition of the amino acids constituting ELPs. At a temperature below the inverse transition temperature (Tt), ELPs are soluble, but insoluble when the temperature exceeds Tt. Furthermore, this feature is retained even when ELP is fused to the protein of interest. These unique properties make ELP very useful for a wide variety of biomedical applications (e.g. protein purification, drug delivery etc.) and it can be expected that smart biopolymers will play a significant role in the development of most new materials and technologies. Here we present the structure and properties of thermally responsive elastin-like polypeptides with a particular emphasis on biomedical and biotechnological application.
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men (1993)

These data do not prove a causal relation, but they provide evidence of an association between a high intake of vitamin E and a lower risk of coronary heart disease in men. Public policy recommendations with regard to the use of vitamin E supplements should await the results of additional studies.
Rat embryonic stem cells create new era in development of genetically manipulated rat models. (2015)

Embryonic stem (ES) cells are isolated from the inner cell mass of a blastocyst, and are used for the generation of gene-modified animals. In mice, the transplantation of gene-modified ES cells into recipient blastocysts leads to the creation of gene-targeted mice such as knock-in and knock-out mice; these gene-targeted mice contribute greatly to scientific development. Although the rat is considered a useful laboratory animal alongside the mouse, fewer gene-modified rats have been produced due to the lack of robust establishment methods for rat ES cells. A new method for establishing rat ES cells using signaling inhibitors was reported in 2008. By considering the characteristics of rat ES cells, recent research has made progress in improving conditions for the stable culture of rat ES cells in order to generate gene-modified rats efficiently. In this review, we summarize several advanced methods to maintain rat ES cells and generate gene-targeted rats.
Single color extraction and image query (2002)

We propose a method for automatic color extraction and indexing to support color queries of image and video databases. This approach identifies the regions within images that contain colors from predetermined color sets. By searching over a large number of color sets, a color index for the database is created in a fashion similar to that for file inversion. This allows very fast indexing of the image collection by the color contents of the images. Furthermore, information about the identified regions, such as the color set, size, and location, enables a rich variety of queries that specify both color content and spatial relationships of regions. We present the single color extraction and indexing method and contrast it to other color approaches. We examine single and multiple color extraction and image query on a database of 3000 color images.
Palbociclib and Letrozole in Advanced Breast Cancer (2016)

Among patients with previously untreated ER-positive, HER2-negative advanced breast cancer, palbociclib combined with letrozole resulted in significantly longer progression-free survival than that with letrozole alone, although the rates of myelotoxic effects were higher with palbociclib-letrozole. (Funded by Pfizer; PALOMA-2 ClinicalTrials.gov number, NCT01740427 .).
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. (1996)

Sildenafil (Viagra, UK-92,480) is a novel oral agent under development for the treatment of penile erectile dysfunction. Erection is dependent on nitric oxide and its second messenger, cyclic guanosine monophosphate (cGMP). However, the relative importance of phosphodiesterase (PDE) isozymes is not clear. We have identified both cGMP- and cyclic adenosine monophosphate-specific phosphodiesterases (PDEs) in human corpora cavernosa in vitro. The main PDE activity in this tissue was due to PDE5, with PDE2 and 3 also identified. Sildenafil is a selective inhibitor of PDE5 with a mean IC50 of 0.0039 microM. In human volunteers, we have shown sildenafil to have suitable pharmacokinetic and pharmacodynamic properties (rapid absorption, relatively short half-life, no significant effect on heart rate and blood pressure) for an oral agent to be taken, as required, prior to sexual activity. Moreover, in a clinical study of 12 patients with erectile dysfunction without an established organic cause, we have shown sildenafil to enhance the erectile response (duration and rigidity of erection) to visual sexual stimulation, thus highlighting the important role of PDE5 in human penile erection. Sildenafil holds promise as a new effective oral treatment for penile erectile dysfunction.
SYNTHESIS OF SOME NEW 2-ARYLOXY AND 2-ALKYLOXY PYRIDINES (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSYNTHESIS OF SOME NEW 2-ARYLOXY AND 2-ALKYLOXY PYRIDINESARTHUR J. HILL and WILLIAM J. McGRAWCite this: J. Org. Chem. 1949, 14, 5, 783–789Publication Date (Print):September 1, 1949Publication History Published online1 May 2002Published inissue 1 September 1949https://doi.org/10.1021/jo01157a010Request reuse permissionsArticle Views328Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (514 KB) Get e-Alertsclose Get e-Alerts
Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine β and γ proteins (1997)

Three human MGSA/GRO genes encode 3 highly related chemokines, MGSA/GRO alpha, -beta and -gamma. All 3 MGSA/GRO proteins bind to the same receptors, but with differing affinities, and stimulate a number of biological responses including chemotaxis, angiogenesis, and growth regulation. We have previously demonstrated that MGSA/GRO alpha can be isolated from culture medium conditioned by malignant melanoma cells and that continuous secretion of MGSA/GRO alpha contributes to the transformation of immortalized murine melanocytes. The present study was designed to determine whether MGSA/GRO beta or -gamma have similar effects on melanocyte tumorigenicity. Stable Melan-a clones expressing either human MGSA/GRO beta or -gamma exhibited enhanced ability to form large colonies in soft agar and tumors in nude mice. The clones expressing the MGSA/GRO beta or -gamma transgene formed tumors within 2 months after injection; the tumors were highly pigmented and expressed immunoreactive MGSA/GRO beta or -gamma protein. Furthermore, when conditioned medium from Melan-a clones expressing MGSA/GRO alpha, -beta or -gamma transgenes were examined for the ability to induce angiogenesis in the rat cornea, strong angiogenic responses were observed. This angiogenic response was blocked by antibodies to the respective MGSA/GRO protein, but not by normal rabbit serum. By contrast, angiogenic responses were observed in only 2 of 12 corneal implants (17%) containing medium conditioned by Melan-a clones expressing the neomycin resistance marker alone.
Abstract 1505: Sunitinib-Induced Cardiotoxicity is Mediated in Part via Direct Effects on Cardiac Myocytes and Smooth Muscle Cells (2007)

Tyrosine kinase inhibitors (TKI) have revolutionized cancer therapy, spawning over 500 clinical trials, yet cardiotoxicities are emerging. Sunitinib, a multi-targeted TKI, prolongs life in renal cell and gastrointestinal cancer patients, but hypertension and heart failure have required treatment adjustments. Objective: Sunitinib cardiotoxicity may be due, in part, to direct effects on smooth muscle and cardiac myocytes. Methods: We used C57Bl/6J mice, rat neonatal cardiomyocytes (NCM), and human coronary artery smooth muscle cells (SMC) treated with Sunitinib to measure drug-induced cardiovascular toxicity. Structural (transmission electron microscopy, immunohistochemistry (IHC)/confocal microscopy) and functional [apoptosis/survival, nitric oxide synthesis (intracellular and extracellular), signaling] effects were assessed [real-time PCR, Western blotting, receptor phosphorylation (immunoprecipitation/Western blotting)]. Results: We show mitochondrial injury in hearts from Sunitinib treated mice which persisted off of the drug. In vitro , Sunitinib accumulated in myocytes, caused myofibrillar disorganization, mitochondrial injury, and localized to the lysosomes. Sunitinib caused reductions in akt, MAPK, and AMPK signaling, and activated pro-apoptotic caspase-9 in NCM and SMC with similar effects in large and small vessel endothelial cells. In hearts of Sunitinib-treated mice, we found similar changes in signaling pathways. Conclusion: Sunitinib causes direct cardiac myocyte and smooth muscle cell toxicities, which may contribute to the cardiovascular side effects seen in patients. Further understanding of these mechanisms will guide monitoring, intervention and future rational drug design.
Mitochondrial DNA Variants of Respiratory Complex I that Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-Related Macular Degeneration (2009)

Loci defining the mtDNA T2 haplogroup and Complex I are reasonable targets for novel functional analyses and therapeutic research in AMD.
Demodulating High Frequency Resonance Signals for Bearing Fault Detection (1990)

The high frequency resonance technique is an established means both of detecting early failure and of monitoring damage growth to roll element bearings. Applying the technique normally involves selecting a narrow band signal (often centred on a structural resonance) and recovering its demodulated envelope (to identify frequencies characteristic of damage to particular elements). This was formerly performed by analogue circuitry, whose parameters are not readily changed. If digital demodulation attempted to replicate the analogue process stage by stage, the computational effort would be so great as to render it impracticable. The theoretical basis of these procedures is outlined and examples of application to vibration data from bearing test rigs are given. Characteristic repetition frequencies can be identified in spectra of the demodulated envelopes and faulty elements identified.
Fusion Antibody for Alzheimer's Disease with Bidirectional Transport Across the Blood−Brain Barrier and Aβ Fibril Disaggregation (2007)

Delivery of monoclonal antibody therapeutics across the blood-brain barrier is an obstacle to the diagnosis or therapy of CNS disease with antibody drugs. The immune therapy of Alzheimer's disease attempts to disaggregate the amyloid plaque of Alzheimer's disease with an anti-Abeta monoclonal antibody. The present work is based on a three-step model of immune therapy of Alzheimer's disease: (1) influx of the anti-Abeta monoclonal antibody across the blood-brain barrier in the blood to brain direction, (2) binding and disaggregation of Abeta fibrils in brain, and (3) efflux of the anti-Abeta monoclonal antibody across the blood-brain barrier in the brain to blood direction. This is accomplished with the genetic engineering of a trifunctional fusion antibody that binds (1) the human insulin receptor, which mediates the influx from blood to brain across the blood-brain barrier, (2) the Abeta fibril to disaggregate amyloid plaque, and (3) the Fc receptor, which mediates the efflux from brain to blood across the blood-brain barrier. This fusion protein is a new antibody-based therapeutic for Alzheimer's disease that is specifically engineered to cross the human blood-brain barrier in both directions.
Identification of a Novel GTPase, the Inducibly Expressed GTPase, That Accumulates in Response to Interferon γ (1996)

Interferon gamma is a pleiotropic cytokine that regulates many immune functions. We have identified a novel protein, inducibly expressed GTPase (IGTP), whose expression was regulated by interferon gamma in macrophages. In mouse RAW 264.7 macrophages, IGTP mRNA levels were almost undetectable but increased within 1 h of exposure to interferon gamma, peaked at very high levels within 3 h, and remained at high levels to at least 48 h; pretreatment of the cells with cycloheximide blocked the majority of mRNA accumulation. In the mouse, the mRNA was highly expressed in thymus, spleen, lung, and small intestine. Using interspecific backcross analysis, the Igtp gene was mapped to mouse chromosome 11. The IGTP cDNA encoded a putative polypeptide of Mr 48,507 and pI 7.79 that contained three consensus GTP binding motifs, GXXXXGK(S/T), DXXG, and NTKXD. Both IGTP that had been immunoprecipitated from RAW cells and a glutathione S-transferase IGTP fusion protein were able to convert GTP to GDP in vitro. Subcellular protein fractionation and Western blotting localized IGTP to the cytosol of RAW cells. In addition, the protein was homologous to proteins encoded by three previously cloned cDNAs, IRG-47, TGTP/Mg21, and LRG-47, and thus may be representative of a new family of interferon gamma-regulated GTPases.