gebhart/patrepeval huggingface dataset:
SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts (2008)

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The SIRT1, mammalian homologue of Sir2, regulates signaling for favoring survival in stress. But whether SIRT1 has the function to influence cell viability and senescence under non-stressed conditions in human diploid fibroblasts is far from unknown. Our data showed that enforced SIRT1 expression promoted cell proliferation and antagonized cellular senescence with the characteristic features of delayed Senescence-Associated beta-galactosidase (SA-beta-gal) staining, reduced Senescence-Associated Heterochromatic Foci (SAHF) formation and G1 phase arrest, increased cell growth rate and extended cellular lifespan in human fibroblasts, while dominant-negative SIRT1 allele (H363Y) did not significantly affect cell growth and senescence but displayed a bit decreased lifespan. Western blot results showed that SIRT1 reduced the expression of p16(INK4A) and promoted phosphorylation of Rb. Our data also exposed that overexpression of SIRT1 was accompanied by enhanced activation of ERK and S6K1 signaling. These effects were mimicked in both WI38 cells and 2BS cells by concentration-dependent resveratrol, a SIRT1 activator. It was noted that treatment of SIRT1-.transfected cells with Rapamycin, a mTOR inhibitor, reduced the phosphorylation of S6K1 and the expression of Id1, implying that SIRT1-induced phosphorylation of S6K1 may be partly for the decreased expression of p16(INK4A) and promoted phosphorylation of Rb in 2BS. It was also observed that the expression of SIRT1 and phosphorylation of ERK and S6K1 was declined in senescent 2BS. These findings suggested that SIRT1-promoted cell proliferation and antagonized cellular senescence in human diploid fibroblasts may be, in part, via the activation of ERK/ S6K1 signaling.
Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones (2000)

A series of imidazopyridine thiazolidine-2,4-diones were designed and synthesized from their corresponding pyridines. These compounds represent conformationally restricted analogues of the novel hypoglycemic compound rosiglitazone (5). The series was evaluated for its effect on insulin-induced 3T3-L1 adipocyte differentiation in vitro and its hypoglycemic activity in the genetically diabetic KK mouse in vivo. The structure-activity relationships are discussed. On the basis of the in vivo potency, 5-[4-(5-methoxy-3-methyl-3H-imidazo[4, 5-b]pyridin-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (19a) was selected as the candidate for further studies in a clinical setting.
Healing and meditation (2003)

Abstract This paper is a continuation of an earlier discussion on the theme of healing published in the last issue of Sacred Space 1 . It is based on lectures given at the Healing and Meditation conference, organised by the World Community for Christian Meditation held at Worth Abbey in the UK in 2002. This is very much a personal account of involvement in healing work, and reinforces the need for humility and mystery in healing. Copyright © 2003 Whurr Publishers Ltd.
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonistsDaljit S. Dhanoa, Scott W. Bagley, Raymond S. L. Chang, Victor J. Lotti, Tsing Bau Chen, Salah D. Kivlighn, Gloria J. Zingaro, Peter K. S. Siegl, Prasun K. Chakravarty, and Cite this: J. Med. Chem. 1993, 36, 23, 3738–3742Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jm00075a033https://doi.org/10.1021/jm00075a033research-articleACS PublicationsRequest reuse permissionsArticle Views648Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Autocomplete painting repetitions (2014)

Painting is a major form of content creation, offering unlimited control and freedom of expression. However, it can involve tedious manual repetitions, such as stippling large regions or hatching complex contours. Thus, a central goal in digital painting research is to automate tedious repetitions while allowing user control. Existing methods impose a sequential order, in which a small exemplar is prepared and then cloned through additional gestures. Such sequential mode may break the continuous, spontaneous flow of painting. Moreover, it is more suitable for homogeneous areas than nuanced variations common in real paintings. We present an interactive digital painting system that auto-completes tedious repetitions while preserving nuanced variations and maintaining natural flows. Specifically, users paint as usual, while our system records and analyzes their workflows. When potential repetition is detected, our system predicts what the user might want to draw and offers auto-completes that adjust to the existing shape-color context. Our method eliminates the need for sequential creation-cloning and better adapts to the local painting contexts. Furthermore, users can choose to accept, ignore, or modify those predictions and thus maintain full control. Our method can be considered as the painting analogy of auto-completes in common typing and IDE systems. We demonstrate the quality and usability of our system through painting results and a pilot user study.
A New Method for Attenuation Coefficient Measurement in the Liver (2002)

This new method, which was more sensitive in detecting fatty infiltration than the spectral shift central frequency method, was considered usable for evaluating the attenuation coefficient of the liver in vivo.
Parenteral nutrition: formulation, monitoring, and complications. (2007)

Because decreased caloric and nutrient intake can complicate the course of both mild and serious illness, parenteral nutrition (PN) is an important feeding modality for patients unable to receive adequate enteral nutrition. Although the effectiveness of PN has not been proven in animals, human studies have shown that using PN in appropriately selected cases can improve clinical outcome, reduce hospitalization time, and even reduce the overall cost of patient care. PN formulations for animals are readily available through pharmacies. This article provides practitioners with basic information on calculating and using PN in patients. Information is also provided on monitoring patients receiving PN as well as ways to identify and overcome common complications in animals receiving PN.
The Professional Sports Community Protection Act: Congress' Best Response to Raiders (1987)

On March 1, 1980, Al Davis made good on a threat.After more than a year of unsuccessful negotiation on a new lease agreement with the Oakland-Alameda County Coliseum Commission, Davis, the managing general partner of the National Football League's Oakland Raiders, signed a "memorandum of agreement" with the
Use of sorption promoters to increase systemic absorption of coumarin from transdermal drug delivery systems. (1988)

In previous communications it was shown that coumarin is transdermally well absorbed. Increasing the application area for a coumarin ointment from 5 cm2 to 30 cm2, the absolute bioavailability increases from 8.6% to 66%. Using a transdermal drug delivery system (TDDS) based on an elastomer matrix, the absolute bioavailability was 21.9%. By selecting a proper sorption promoter (Labrafil), the absolute bioavailability increased to 71%. No correlation was found between tlag, flux or amount permeated obtained from ex vivo flux measurements, and the in vivo parameters Cmax and AUC. Whereas the bioavailability of a large area application of coumarin ointment is practically the same as with a small TDDS, the latter one is preferred to maintain a therapeutic concentration over a 24 h or 48 h period.
Current status of dengue vaccines and prospects for the future. (1987)

Dengue vaccine development is complicated by the existence of four viral serotypes, the lack of in vitro assays of virulence for humans and the lack of an animal model for assessing viral attenuation. Experience gained from human testing shows that the in vitro phenotypic growth characteristics used for selecting candidate dengue viruses do not always correlate with lack of pathogenicity in vivo. While testing continues on live, attenuated, viral strains, alternative dengue vaccine products produced as recombinant subunit vaccines are being sought.
Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma (2018)

These data showed that the membrane-bound CD40L mutant may promote cellular senescence and initiate the SASP of NSCLC cells in an NF-κB-dependent manner. Therefore, CD40L-M-induced senescence may be a potential approach to protect against lung adenocarcinoma.
ChemInform Abstract: Preparation and C‐Alkylation of Peptides with Aminomalonate Building Blocks. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Phase II Trial of Paclitaxel and Dacarbazine with Filgrastim Administration in Advanced Malignant Melanoma (2002)

A Phase II trial was conducted in patients with advanced malignant melanoma with intravenous Paclitaxel and Dacarbazine (DTIC). The initial starting dose for Paclitaxel was 135 mg/m2 followed by DTIC 800 mg/m2. Due to the lack of myelosuppression and other toxicities, the starting dose for Paclitaxel was escalated to 250 mg/m2 and the dose for DTIC escalated to 1000 mg/m2. Twenty-five patients were enrolled in this study. Among the 25 patients assessable for response, three patients had a partial response with a response rate of 12% (CI 3-31%) and one patient had stable disease. Three additional patients showed evidence of anti-tumor activity with minor responses. For patients who had no prior chemotherapy or biochemotherapy, the response rate was 20%. Toxicity was generally tolerable and included mainly neurotoxicity from Paclitaxel. At the doses and schedule used, the combination of Paclitaxel and DTIC did not appear to increase the response rate compared to each agent used singly.
Prolonged administration of low-dose interleukin-2 in human immunodeficiency virus-associated malignancy results in selective expansion of innate immune effectors without significant clinical toxicity (1995)

Ten adult patients with human immunodeficiency virus (HIV)-associated malignancies (five with lymphoma and five with Kaposi's Sarcoma) were treated with a daily subcutaneous injection of interleukin-2 (IL-2) for 90 consecutive days in a phase I dose-escalation study. Seven patients had absolute CD4 counts below 200/mm3 at the time malignancy was diagnosed. Each lymphoma patient had obtained a complete or partial remission with standard chemotherapy before initiating IL-2. The daily dose of IL-2 did not change during the 90-day course of therapy. Seventeen courses of IL-2 therapy were completed at doses ranging from 0.4 x 10(6) U/m2/d to 1.2 x 10(6) U/m2/d without significant (grade III) toxicity. Two of two patients experienced grade III toxicity within 21 days of initiating IL-2 at a dose of 1.4 x 10(6) U/m2/d, but both patients subsequently completed 90 days of therapy at the maximum tolerated dose (MTD) of 1.2 x 10(6) U/m2/d. Although there were no significant increases or decreases in T-cell subsets at any dose level, there was an increase in absolute natural killer (NK) cell number at the three highest doses of IL-2 (mean percent increase 247; 95% confidence interval, 124 to 369) that was statistically significant (Wilcoxon one-sample signed rank test, P = .015). One patient developed an anti-IL-2 antibody titer that correlated with minimal NK cell expansion in vitro and in vivo. An increase in eosinophils was noted during 9 of 17 courses of IL-2 therapy without correlation to IL-2 dose, prior course of IL-2, or NK cell expansion. At the MTD, there was no consistent increase in the plasma HIV RNA level over time. Three of 10 patients had progressive disease while on study. During 50 months of IL-2 therapy, no patient was treated for an opportunistic infection. We conclude that daily low dose subcutaneous IL-2 can be self-administered safely with good compliance for prolonged periods of time to patients with HIV-associated malignancies, including those with profound immune deficiency. The majority of patients show selective expansion of innate immune effectors, ie, NK cells and/or eosinophils, in the absence of significant clinical toxicity or increased viral burden. These results suggest that low-dose IL-2 therapy should be studied further in phase II clinical trials for evidence of activity against malignancy and opportunistic infection in this patient population.
The 11β‐Hydroxysteroid Dehydrogenase System, A Determinant of Glucocorticoid and Mineralocorticoid Action (1997)

11Beta-hydroxysteroid dehydrogenases (11beta-HSD) catalyse the interconversion of active glucocorticoids (cortisol, corticosterone) and their inert 11-keto derivatives (cortisone, 11-dehydrocorticosterone). The type-2 isozyme (11beta-HSD-2) is a high-affinity dehydrogenase that catalyses the rapid inactivation of glucocorticoids, thus ensuring selective access of aldosterone to otherwise non-selective mineralocorticoid receptors in the distal nephron. Mutations of the gene encoding 11beta-HSD-2 are responsible for the syndrome of apparent mineralocorticoid excess, in which cortisol illicitly occupies mineralocorticoid receptors, causing hypertension and hypokalaemia. 11Beta-HSD-2 is also highly expressed in the placenta and mid-gestation fetus, where it may protect developing tissues from the often deleterious actions of glucocorticoids upon fetal growth and organ maturation. 11Beta-HSD-1 is probably an 11beta-reductase in vivo. Its function is obscure, but may amplify glucocorticoid action during the diurnal nadir, drawing upon the substantial circulating levels of 11-keto steroids. Both isozymes are regulated during ontogeny and by a series of hormonal and other factors. 11Beta-HSD provide an important control of glucocorticoid action at a cellular level, and may represent new targets for therapeutic intervention.
The US West Advanced Technologies prototype multimedia communication system (2003)

The authors describe a prototype geographically distributed, real-time multimedia communication system currently in everyday use at US West Advanced Technologies. To test it, nine of approximately 40 researchers in the Science and Technology Division have been relocated from the US West Advanced technologies headquarters in Englewood, Colorado, to Boulder, Colorado, a distance of some 40 miles. After an explanation of the technical infrastructure of the system and some of the choices made in building it, the authors discuss some of the problems encountered and some of the lessons learned from this experience. The experience described is grouped into two main areas: (1) the engineering of the system, and (2) the behavioral and social aspects of using and living with the system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The rendezvous algorithm (2007)

We consider the problem of multiclass classification where both labeled and unlabeled data points are given. We introduce and demonstrate a new approach for estimating a distribution over the missing labels where data points are viewed as nodes of a graph, and pairwise similarities are used to derive a transition probability matrix P for a Markov random walk between them. The algorithm associates each point with a particle which moves between points according to P. Labeled points are set to be absorbing states of the Markov random walk, and the probability of each particle to be absorbed by the different labeled points, as the number of steps increases, is then used to derive a distribution over the associated missing label. A computationally efficient algorithm to implement this is derived and demonstrated on both real and artificial data sets, including a numerical comparison with other methods.
Cancellation of Nonlinear Phase Distortion in Self-Homodyne Coherent Systems (2010)

Using the self-homodyne detection scheme, it is possible to compensate for the nonlinear phase distortion that, if left uncompensated, would distort the received constellation diagram. The suggested compensation method is evaluated using numerical simulations and validated in an experiment.
Architecture of metaphase chromosomes and chromosome scaffolds. (1983)

We have developed procedures for depositing intact mitotic chromosomes and isolated residual scaffolds on electron microscope grids at controlled and reproducible levels of compaction. The chromosomes were isolated using a recently developed aqueous method. Our study has addressed two different aspects of chromosome structure. First, we present a method for improved visualization of radial chromatin loops in undisrupted mitotic chromosomes. Second, we have visualized a nonhistone protein residual scaffold isolated from nuclease-digested chromosomes under conditions of low salt protein extraction. These scaffolds, which have an extremely simple protein composition, are the size of chromosomes, are fibrous in nature, and are found to retain differentiated regions that appear to derive from the kinetochores and the chromatid axis. When our standard preparation conditions were used, the scaffold appearance was found to be very reproducible. If the ionic conditions were varied, however, the scaffold appearance underwent dramatic changes. In the presence of millimolar concentrations of Mg++ or high concentrations of NaCl, the fibrous scaffold protein network was observed to undergo a lateral aggregation or assembly into a coarse meshlike structure. The alteration of scaffold structure was apparently reversible. This observation is consistent with a model in which the scaffolding network plays a dynamic role in chromosome condensation at mitosis.
Enzyme-linked immunosorbent assay for detection of Staphylococcus epidermidis antibody in experimental S. epidermidis endocarditis (1986)

The immune response against Staphylococcus epidermidis, as determined by an enzyme-linked immunosorbent assay, was evaluated in experimental S. epidermidis infections in rabbits. Antigens from 8 of 10 clinical S. epidermidis strains detected significant antibody production in five rabbits immunized with different strains of S. epidermidis and in five of six rabbits with experimental endocarditis caused by four different strains. The antigens from two strains detected antibody production in all rabbits, and strain ATCC 14990 discriminated best between positive and negative samples. Consecutive blood samples from rabbits with endocarditis and control rabbits with bacteremia, which were successfully prevented from developing endocarditis by using prophylactic antibiotics, were examined by using an enzyme-linked immunosorbent assay and an ultrasonic extract of strain ATCC 14990 as the antigen. This assay discriminated between rabbits with endocarditis and rabbits with uncomplicated bacteremia. Antibody production was detected as early as 3 days after the onset of infection in rabbits with endocarditis.
Tocilizumab, a Proposed Therapy for the Cachexia of Interleukin6-Expressing Lung Cancer (2014)

Our clinical and experimental studies revealed that serum IL-6 is a surrogate marker for evaluating cachexia and the prognosis of patients with chemotherapy resistant metastatic lung cancer and that tocilizumab has the potential of improving prognosis and ameliorating the cachexia that so devastates their quality of life. This outcome greatly encourages our clinical trials to evaluate the safety and efficacy of tocilizumab treatment for patients with increased serum IL-6.
Thermal conductance imaging of graphene contacts (2014)

Suspended graphene has the highest measured thermal conductivity of any material at room temperature. However, when graphene is supported by a substrate or encased between two materials, basal-plane heat transfer is suppressed by phonon interactions at the interfaces. We have used frequency domain thermoreflectance to create thermal conductance maps of graphene contacts, obtaining simultaneous measurements of the basal-plane thermal conductivity and cross-plane thermal boundary conductance for 1–7 graphitic layers encased between titanium and silicon dioxide. We find that the basal-plane thermal conductivity is similar to that of graphene supported on silicon dioxide. Our results have implications for heat transfer in two-dimensional material systems, and are relevant for applications such as graphene transistors and other nanoelectronic devices.
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields (2014)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPolydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical FieldsYanlan Liu†‡, Kelong Ai†, and Lehui Lu*†View Author Information† State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China‡ Chinese Academy of Sciences, Beijing 100039, People's Republic of China*Tel.: +86 431 85262418. Fax: +86 431 85262406. E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 9, 5057–5115Publication Date (Web):February 11, 2014Publication History Received27 July 2013Published online11 February 2014Published inissue 14 May 2014https://pubs.acs.org/doi/10.1021/cr400407ahttps://doi.org/10.1021/cr400407areview-articleACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views110289Altmetric-Citations3853LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amines,Coating materials,Ions,Metals,Nanoparticles Get e-Alerts