gebhart/patrepeval huggingface dataset:
G4-FET Based Voltage Reference (2004)

A precise and stable voltage reference is essential to analog/mixed-signal SoC (systemon-a-chip) applications. The most commonly used voltage reference in standard CMOS processes, the bandgap voltage reference, is limited due to output drift in wide temperature range applications. The temperature drift associated with the bandgap voltage reference is non-linear, thus temperature compensation is difficult. A new reference circuit, the JFET-based voltage reference, is proven to be more temperature stable. However, the JFET-based voltage reference requires a specialized Bi-CMOS process with additional fabrication steps to alter the channel doping for selected devices. The purpose of this thesis is to investigate the feasibility of the JFETbased voltage reference circuit topology in a CMOS-compatible process. The novel G-FET device fabricated on a standard PDSOI (partially-depleted silicon-on-insulator) CMOS process is chosen as an alternative to the JFET device. A theoretical development of the G-FET is summarized and results of device characterization are presented. Based on device characterization, all four gates of the G-FET device are exploited to achieve an equivalent circuit operation without requiring any additional process steps. Results from this characterization are used to design an improved voltage reference based on G-FETs and test results from a prototype reference circuit are shown including output temperature coefficient, output noise, and power supply rejection. The output voltage achieves approximately constant output variation with temperature over the temperature range of −5 °C to 85 °C, implying that the circuit may be readily temperature compensated, in this case by an inverse-PTAT (proportional-to-absolutetemperature) current. Finally, suggestions for improved reference performance and fully monolithic compatibility are given.
Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells (2003)

Aurora-A, a member of the Aurora/Ipl1-related kinase family, is overexpressed in various types of cancer and considered to play critical roles in tumorigenesis. To better understand the pathological effect of Aurora-A activation, it is first necessary to elucidate the physiological functions of Aurora-A. Here, we have investigated the roles of Aurora-A in mitotic progression with the small interfering RNA, antibody microinjection, and time lapse microscopy using human cells. We demonstrated that suppression of Aurora-A by small interfering RNA caused multiple events to fail in mitosis, such as incorrect separation of centriole pairs, misalignment of chromosomes on the metaphase plate, and incomplete cytokinesis. Antibody microinjection of Aurora-A into late G2 cells induced dose-dependent failure in separation of centriole pairs at prophase, indicating that Aurora-A is essential for proper separation of centriole pairs. When we injected anti-Aurora-A antibodies into prometaphase cells that had separated their centriole pairs, chromosomes were severely misaligned on the metaphase plate, indicating that Aurora-A is required for proper movement of chromosomes on the metaphase plate. Furthermore, inhibition of Aurora-A at metaphase by microinjected antibodies prevented cells from completing cytokinesis, suggesting that Aurora-A also has important functions in late mitosis. These results strongly suggest that Aurora-A is essential for many crucial events during mitosis and that the phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in human cells.
Use of Pressure- and Rate-Transient Techniques for Analyzing Core Permeability Tests for Unconventional Reservoirs (2012)

Abstract The permeability of unconventional gas/oil reservoirs is a critical control on economic viability of unconventional plays, yet its determination, particularly in ultra-low permeability shale reservoirs, remains a challenge. Some of the difficulties in obtaining accurate permeability measurements in the lab include: recreating in-situ stress and fluid saturation conditions; establishing the appropriate sample size for measurement; correcting for sorption of gases on kerogen and clays; accounting for non-Darcy flow (slippage and diffusion); among many others. Unsteady-state measurements are most popular for establishing permeability in ultra-tight rock; both pressure-decay and pulse-decay decay techniques have been used. Analysis methods for these techniques have been established, but there remain some questions about whether these analysis methods are optimal for establishing permeability. In this work, we investigate the use of pressure- and rate-transient analysis (PTA/RTA) methods to analyze data obtained from a new core plug analysis procedure, designed specifically to extract information (permeability and pore volume) from ultra-low permeability reservoir samples (core plugs). The new analysis procedure calls for analyzing the rate and/or pressure data analogously to larger-scale well-test/production data. During a core plug production test for example, derivative analysis of rate-normalized pseudo-pressure change is first analyzed to determine flow-regimes. For homogenous samples, linear flow is followed by boundary-dominated flow; for this scenario, permeability can be established by noting the end of linear flow and using the distance of investigation calculation to calculate permeability (knowing core length). Permeability can also be established independently from a linear flow (square-root of time) plot. Pore volume can also be established. Analytical simulation is used to verify estimates of permeability and pore volume from RTA/PTA. Our solutions allow complex unconventional gas reservoir behavior to be incorporated, including corrections for adsorbed gas and non-Darcy flow. Our new methodology is tested using various simulated cases which differ due to: 1) reservoir type (single or dual porosity, homogenous or heterogeneous); 2) matrix permeability; 3) analysis type (post injection/falloff production test, or post-injection falloff); 4) adsorption (compressed gas storage only or compressed + adsorbed gas storage); Darcy or non-Darcy flow. In all cases, reasonable estimates of permeability and pore volume were obtained, provided the appropriate corrections are made. We believe this new technique for analyzing core data, and the proposed core testing procedure, will considerably improve on current techniques for establishing permeability and pore volume of unconventional reservoir samples.
4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6 (2010)

Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the X-ray crystallographic analysis of representative compounds bound to monomeric CDK6. Significant selectivity for CDK4/6 over CDK1 and CDK2 was demonstrated with several compounds in both enzymatic and cellular assays.
Recombinant Yellow Fever Viruses Are Effective Therapeutic Vaccines for Treatment of Murine Experimental Solid Tumors and Pulmonary Metastases (2000)

We have genetically engineered an attenuated yellow fever (YF) virus to carry and express foreign antigenic sequences and evaluated the potential of this type of recombinant virus to serve as a safe and effective tumor vaccine. Live-attenuated YF vaccine is one of the most effective viral vaccines available today. Important advantages include its ability to induce long-lasting immunity, its safety, its affordability, and its documented efficacy. In this study, recombinant live-attenuated (strain 17D) YF viruses were constructed to express a cytotoxic T-lymphocyte epitope derived from chicken ovalbumin (SIINFEKL). These recombinant viruses replicated comparably to the 17D vaccine strain in cell culture and stably expressed the ovalbumin antigen, and infected cells presented the antigen in the context of major histocompatibility complex class I. Inoculation of mice with recombinant YF virus elicited SIINFEKL-specific CD8(+) lymphocytes and induced protective immunity against challenge with lethal doses of malignant melanoma cells expressing ovalbumin. Furthermore, active immunotherapy with recombinant YF viruses induced regression of established solid tumors and pulmonary metastases. Thus, recombinant YF viruses are attractive viral vaccine vector candidates for the development of therapeutic anticancer vaccines.
HIV Infection Does Not Affect the Performance of Noninvasive Markers of Fibrosis for the Diagnosis of Hepatitis C Virus-Related Liver Disease (2005)

The diagnostic performance of the evaluated noninvasive markers of liver fibrosis is equivalent in HCV/HIV-coinfected and HCV-infected subjects. These tests may be of value for the clinical evaluation of HCV/HIV-coinfected patients and warrant further study.
Single-carrier frequency-domain equalization for space-time block-coded transmissions over frequency-selective fading channels (2001)

We propose an Alamouti-like scheme for combining space-time block-coding with single-carrier frequency-domain equalization. With two transmit antennas, the scheme is shown to achieve significant diversity gains at low complexity over frequency-selective fading channels.
Comparing COVID-19 vaccine allocation strategies in India: A mathematical modelling study (2020)

Our findings support global recommendations to prioritize COVID-19 vaccine allocation for older age groups. Relative differences between allocation strategies were reduced as the speed of vaccine rollout was increased. Optimal vaccine allocation strategies will depend on vaccine characteristics, strength of concurrent non-pharmaceutical interventions, and region-specific goals.
How to construct random functions (1986)

A constructive theory of randomness for functions, based on computational complexity, is developed, and a pseudorandom function generator is presented. This generator is a deterministic polynomial-time algorithm that transforms pairs ( g , r ), where g is any one-way function and r is a random k -bit string, to polynomial-time computable functions ƒ r : {1, … , 2 k } → {1, … , 2 k }. These ƒ r 's cannot be distinguished from random functions by any probabilistic polynomial-time algorithm that asks and receives the value of a function at arguments of its choice. The result has applications in cryptography, random constructions, and complexity theory.
Cloning and sequencing of pepC, a cysteine aminopeptidase gene from Lactococcus lactis subsp. cremoris AM2 (1993)

A gene coding for an aminopeptidase (PepC) from Lactococcus lactis subsp. cremoris AM2 was cloned by complementation of an Escherichia coli mutant lacking aminopeptidase activity. The nucleotide sequence was determined. A portion of the predicted amino acid sequence of PepC (436 amino acids) showed strong homology to the active site of cysteine proteases. No signal sequence was found, indicating an intracellular location of the enzyme.
Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences (2004)

In contrast with transfer RNAs and ribosomal RNAs, the majority of the microRNA sequences clearly exhibit a folding free energy that is considerably lower than that for shuffled sequences, indicating a high tendency in the sequence towards a stable secondary structure. A possible usage of this statistical test in the framework of the detection of genuine miRNA sequences is discussed.
Clinicopathological Study of Squamous Cell Carcinoma of the Ear (1984)

Seven cases of squamous cell carcinoma of the ear encountered at Okayama university hospital between 1972 and 1981 were reviewed, and a histopathological study of the temporal bone of one patient was reported. All cases were in advanced stages, T3 in five cases and T4 in two cases according to the TNM classification of ear cancer after Sakai. The external auditory canal was the primary site in five cases and the middle ear in two cases. Only two patients, whose lesions were localized in the shallow portion of the external auditory canal, had lived for a long period without any recurrence at the time of this study. In contrast, the remaining five patients whose lesions extended into the middle ear and mastoid had died of cancer. Histopathological examination of the temporal bone of one patient revealed that the tumor extended both into the internal acoustic meatus along the facial canal and to the extratemporal bone area via the eustachian tube. Additionally, in spite of extensive osteoradionecrosis over the temporal bone due to a full dose of irradiation, active tumor tissue remained in the petrous apex cells of the temporal bone.From these findings, it was assumed that carcinoma of the ear is the most difficult to treat successfully among head and neck malignancies.
Effect of neutralizing antibodies to IL-10 and C5 on the renal damage caused by a pathogenic human anti-dsDNA antibody (2004)

The findings, while confirming the role of IL-10 and activated terminal complement component in the production of antibody at the cellular level and at the site of glomerular immune deposition in this model, respectively, also suggest the beneficial effect of a combined therapy using both anti-IL-10 and anti-C5 mAb to prevent or reduce the effect of the humoral immune response in lupus disease.
Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles. (1991)

The alpha i2 subunit of the inhibitory heterotrimeric guanine nucleotide-binding proteins is highly conserved in mammals and is expressed in all cell types, but its exact function is not yet defined. We have investigated the role of this protein by producing embryonic stem (ES) cells lacking a functional alpha i2 gene. These alpha i2-null cell lines regulate adenylyl cyclase and grow and differentiate in vitro the same as wild-type ES cells. Homologous recombination was used to sequentially inactivate both copies of the alpha i2 gene. The first allele was inactivated by insertion of a neomycin-resistance gene. We modified the hygromycin B-resistance gene for improved expression in ES cells and used this gene to inactivate the remaining normal allele. The techniques used should be generally applicable to other genes whether or not they are expressed in ES cells.
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy (2014)

The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be possible to regenerate injured heart muscle previously thought to be permanently scarred. The mechanisms of benefit are known to be indirect, but the mediators have yet to be identified. Here we pinpoint exosomes secreted by human CDCs as critical agents of regeneration and cardioprotection. CDC exosomes inhibit apoptosis and promote proliferation of cardiomyocytes, while enhancing angiogenesis. Injection of exosomes into injured mouse hearts recapitulates the regenerative and functional effects produced by CDC transplantation, whereas inhibition of exosome production by CDCs blocks those benefits. CDC exosomes contain a distinctive complement of microRNAs, with particular enrichment of miR-146a. Selective administration of a miR-146a mimic reproduces some (but not all) of the benefits of CDC exosomes. The findings identify exosomes as key mediators of CDC-induced regeneration, while highlighting the potential utility of exosomes as cell-free therapeutic candidates.
Cortical reorganisation and chronic pain: implications for rehabilitation (2003)

Recent neuroscientific evidence has revealed that the adult brain is capable of substantial plastic change in such areas as the primary somatosensory cortex that were formerly thought to be modifiable only during early experience. These findings have implications for our understanding of chronic pain. Functional reorganisation in both the somatosensory and the motor system was observed in neuropathic and musculoskeletal pain. In patients with chronic low back pain and fibromyalgia the amount of reorganisational change increases with chronicity; in phantom limb pain and other neuropathic pain syndromes cortical reorganisation is correlated with the amount of pain. These central alterations may be viewed as pain memories that influence the processing of both painful and nonpainful input to the somatosensory system as well as its effects on the motor system. Cortical plasticity related to chronic pain can be modified by behavioural interventions that provide feedback to the brain areas that were altered by somatosensory pain memories or by pharmacological agents that prevent or reverse maladaptive memory formation.
Functional Elements of the Strong psbAI Promoter of Synechococcus elongatus PCC 7942 (2001)

The psbAI gene of the cyanobacterium Synechococcus elongatus PCC 7942 is one of three psbA genes that encode a critical photosystem II reaction center protein, D1. Regulation of the gene family in response to changes in the light environment is complex, occurs at transcriptional and posttranscriptional levels, and results in an interchange of two different forms of D1 in the membrane. Expression of psbAI is downregulated under high-intensity light (high light) in contrast to induction of the other two family members. We show that, in addition to a known accelerated degradation of the psbAI message, promoter activity decreases upon exposure to high light. Unlike the other psbA genes, additional sequences upstream of the psbAI -35 element are required for expression. Mutagenizing the atypical psbAI -10 element from TCTCCT to TATAAT increased the magnitude of expression from both psbAI::lacZ and psbAI::luxAB fusions but did not affect downregulation under high light. Inactivation of group 2 sigma factor genes rpoD2 and sigC, in both wild-type and -10-element mutagenized backgrounds, resulted in elevated psbAI::luxAB expression but did not alter the response to high light. The results are consistent with redundancy of promoter recognition among cyanobacterial group 2 sigma factors. Electrophoretic mobility shift assays showed that the DNA sequence corresponding to the untranslated leader of the psbAI message binds one or more proteins from an S. elongatus extract. The corresponding region of psbAII efficiently competed for this binding activity, suggesting a shared regulatory factor among these disparately regulated genes.
Controlled‐phase acquisition and processing (1994)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1994Controlled‐phase acquisition and processingAuthors: E. Clark TranthamE. Clark TranthamExxon Production Research Companyhttps://doi.org/10.1190/1.1932031 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1932031FiguresReferencesRelatedDetailsCited byOn the seismic wavelet estimative and reflectivity recovering based on linear inversion: Well-to-seismic tie on a real data set from Viking Graben, North SeaIsadora A. S. de Macedo and José Jadsom S. de Figueiredo11 September 2020 | GEOPHYSICS, Vol. 85, No. 5Estimation of the seismic wavelet through homomorphic deconvolution and well log data: application on well‐to‐seismic tie procedure20 December 2019 | Geophysical Prospecting, Vol. 68, No. 4An integrated broadband preprocessing method for towed-streamer seismic dataMehdi Aharchaou and Erik Neumann24 February 2020 | GEOPHYSICS, Vol. 85, No. 2Prestack phase corrections using local seismic attributesSarah Greer, Sergey Fomel, and Michael Fry10 August 2019AVA friendly Q amplitude compensationE. Clark Trantham and Kuang He17 August 2017Marine broadband technology: History and remaining challenges from an end-user perspectiveJoseph M. Reilly31 March 2016 | The Leading Edge, Vol. 35, No. 4Broadband technology; history and remaining challenges from an end-user perspectiveJoseph M. Reilly19 August 2015Bandwidth enhancement by inverse-Q filtering or time-varying Wiener deconvolution?Mirko van der Baan25 October 2012Bandwidth enhancement: Inverse Q filtering or time-varying Wiener deconvolution?Mirko van der Baan22 June 2012 | GEOPHYSICS, Vol. 77, No. 4How reliable is statistical wavelet estimation?Jonathan A. Edgar and Mirko van der Baan3 June 2011 | GEOPHYSICS, Vol. 76, No. 4Nonstationary phase estimation: A tool for seismic interpretation?Mirko van der Baan, Sergey Fomel, and Mike Perz7 September 2010 | The Leading Edge, Vol. 29, No. 9Nonstationary phase estimation using regularized local kurtosis maximizationMirko van der Baan and Sergey Fomel4 December 2009 | GEOPHYSICS, Vol. 74, No. 6Robust wavelet estimation and blind deconvolution of noisy surface seismicsMirko van der Baan and Dinh-Tuan Pham9 September 2008 | GEOPHYSICS, Vol. 73, No. 5Time-varying wavelet estimation and deconvolution by kurtosis maximizationMirko van der Baan12 February 2008 | GEOPHYSICS, Vol. 73, No. 2 SEG Technical Program Expanded Abstracts 1994ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1994 Pages: 1679 publication data© 1994 Copyright © 1994 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION E. Clark Trantham, (1994), "Controlled‐phase acquisition and processing," SEG Technical Program Expanded Abstracts : 890-894. https://doi.org/10.1190/1.1932031 Plain-Language Summary PDF DownloadLoading ...
Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease (2018)

Parkinson's disease is typically treated with oral dopamine replacement therapies. However, long-term use is complicated by motor fluctuations from intermittent stimulation of dopamine receptors and off-target effects. ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolerated in a Phase I/II first-in-human study, with significant improvements in motor behavior from baseline at 1 year. Here, patients with Parkinson's disease from the open-label trial were followed up in the long term to assess the safety and efficacy of ProSavin after bilateral injection into the putamen. Fifteen patients who were previously treated with ProSavin have been followed for up to 5 years, with some having been seen for 8 years. Eight patients received deep brain stimulation at different time points, and their subsequent assessments continued to assess safety. Ninety-six drug-related adverse events were reported (87 mild, 6 moderate, 3 severe) of which more than half occurred in the first year. The most common drug-related events were dyskinesias (33 events, 11 patients) and on-off phenomena (22 events, 11 patients). A significant improvement in the defined "off" Unified Parkinson's Disease Rating Scale part III motor scores, compared to baseline, was seen at 2 years (mean score 29 · 2 vs. 38 · 4, n = 14, p < 0.05) and at 4 years in 8/15 patients. ProSavin continued to be safe and well tolerated in patients with Parkinson's disease. Moderate improvements in motor behavior over baseline continued to be reported in the majority of patients who could still be evaluated up to 5 years of follow-up.