gebhart/patrepeval huggingface dataset:
A Multi-Pass True Motion Estimation Scheme With Motion Vector Propagation for Frame Rate Up-Conversion Applications (2008)

This paper presents a robust true motion estimation algorithm, designated as MPMVP (Multi-pass and Motion Vector Propagation), to enhance the accuracy of the motion vector fields in frame rate up-conversion applications. The MPMVP uses a multi-pass scheme to progressively refine approximate motion vectors to true motion vectors based upon the motion information acquired in previous passes. The multi-pass motion estimation process uses a large block size to detect the motion vectors within the objects themselves and small block sizes to detect the motion vectors along the object boundaries. Actually, the block size is progressively reduced during the search process. When the motion vector of a block is considered to be sufficiently accurate for motion estimation purposes, the block is said to be converged and the local motion vector search process terminates. A novel technique, referred to as motion vector propagation, is then applied to propagate the motion vector of the converged block to its neighboring blocks. This technique not only ensures that neighboring motion vectors within the same object have a high degree of spatial correlation, but also accelerates the convergence of the motion vectors in the neighboring blocks and therefore reduces the overall computational time and expense of the multi-pass motion vector search procedure. A novel distortion criterion is proposed to enhance the tolerance of the traditional sum-of-absolute-difference measurement technique applied in the motion estimation scheme to noise and shadow effects. The experimental results demonstrate that the proposed true motion estimation algorithm outperforms the traditional full search, 3DRS and TCSBP algorithms in terms of both the smoothness of the generated motion vector fields and the visual quality of the up-converted frames.
Presence of an O-glycosidically linked hexasaccharide in fetuin. (1987)

Examination by gel filtration, thin layer and anion exchange chromatography of the O-linked carbohydrate units released from fetuin by alkaline borohydride treatment indicated the presence in this glycoprotein of an acidic glucosamine-containing hexasaccharide in addition to the previously described tetra- and trisaccharides. The structure of the hexasaccharide was determined to be NeuAc alpha 2----3Gal beta 1----3[NeuAc alpha 2----3Gal beta 1----4GlNAc beta 1----6]GalNAc, on the basis of exoglycosidase digestion, periodate oxidation, and methylation analysis as well as hydrazine-nitrous acid fragmentation. The latter procedure when carried out on the reduced asialohexasaccharide yielded Gal----2-deoxygalactitol and Gal----anhydromannose which were shown to be derived, respectively, from Gal----N-acetylgalactosaminitol and Gal----GlcNAc sequences. Reductive amination of the Gal----anhydromannose disaccharide with [14C] methylamine permitted identification of its linkage as 1----4. While Diplococcus pneumoniae endo-alpha-DN-acetylgalactosaminidase acting on asialofetuin released the sialic acid-free tetra- and trisaccharides (Gal beta 1----3GalNAc), this enzyme did not cleave the peptide attachment of the asialohexasaccharide (Gal beta 1----3 [Gal beta 1----4GlcNAc beta 1----6] GalNAc). The number of O-linked hexa-, tetra-, and trisaccharides per fetuin molecule was determined to be 0.2, 0.7, and 2.1, respectively, on the basis of galactosaminitol analyses. The absence of O-linked N-acetylglucosamine-containing tetra- or pentasaccharides in fetuin suggest that the attachment of this sugar is a rate-limiting step; furthermore, the limited occurrence of the hexasaccharide may indicate that the addition of sialic acid to Gal beta 1----3GalNAc to form the NeuAc alpha 2----3Gal linkage precludes action of the GlcNAc transferase to form the branch point on the GalNAc residue.
Tripartite Upstream Promoter Element Essential for Expression of Saccharomyces cerevisiae Ribosomal Protein Genes (1986)

To initiate a genetic analysis of yeast ribosomal protein gene promoters, we have constructed a gene fusion between the yeast ribosomal protein gene RP39A and the Escherichia coli lacZ gene. This gene fusion contains approximately 1,030 nucleotides of the 5' flanking region and the first 49 1/3 codons of RP39A fused in frame to a large 3' end fragment of lacZ. Whether it is introduced into yeast cells on a moderately high-copy-number plasmid, or integrated into the yeast genome at the RP39A locus, this RP39A-lacZ gene directs the synthesis of a hybrid transcript which encodes beta-galactosidase activity. Deletions in the 5' flanking region of RP39A-lacZ were constructed by linker insertion and BAL 31 mutagenesis. The expression of the mutant genes in yeast cells was assayed by measuring RP39A-lacZ mRNA and beta-galactosidase levels. By these means we have shown that the sequences between nucleotides -256 and -170 upstream of RP39A are essential for expression of this gene. Three sequence motifs, HOMOL1, RPG, and a T-rich region, which were found in that order 5'----3' upstream of most yeast ribosomal protein genes, were present within this interval. We found that substitution of the CYC1-lacZ upstream activation site with the fragment from nucleotides -298 to -172 upstream of RP39A, containing the HOMOL1-RPG-T-rich motif in that 5'----3' orientation, fully restored expression of the CYC1-lacZ gene. The essentially of HOMOL1, the RPG sequence, and the T-rich region for wild-type levels of expression of RP39A, the conserved location and order of these sequence motifs in yeast ribosomal protein genes, and the ability of a DNA fragment carrying these three sequence elements to substitute for the upstream activation site regions of CYC1 indicate that these three oligonucleotides may be essential to the transcription of yeast ribosomal protein genes.
Interval Methods for Processing Geometric Objects (1984)

The authors propose that recursive subdivision techniques be used for some of these tasks and for some special subclasses. Specifically, they advocate the use of interval computation methods that treat the parametric range as an interval. These techniques can be extended to evaluating piecewise continuously differentiable functions over intervals. Also presented is a general schema for designing algorithms using interval evaluation of functions. The power of this methodology is illustrated through the design of algorithms for commonly required processing tasks on geometric objects.
A silicon microcavity selective emitter with smooth surfaces for thermophotovoltaic power generation (2010)

Metal-coated silicon microcavities have been developed as a selective emitter for high-efficiency thermophotovoltaic power generation. In order to examine the effect of surface roughness, two different metal deposition methods, electron-beam evaporation and vacuum arc evaporation, are employed. The surface roughness of a thin metal film with vacuum arc evaporation is much less than that with electron-beam evaporation. For 1.8 µm microcavities with a 50 nm thick Ti film, an emittance peak appears at the wavelength of 3.2 µm, which corresponds well to the first electromagnetic resonance mode. Microcavities with vacuum-arc-evaporated metal exhibit clear electromagnetic resonance modes in the shorter wavelength region, while the emittance reduces to the value for smooth surfaces in the longer wavelength region. By using a Ge photovoltaic cell, the energy conversion efficiency with the present microcavity at 915 °C is found to be 3.2%, which is in good agreement with the estimates with an equivalent circuit model. Assuming the radiation view factor of 0.94, the energy conversion efficiency based on the present model is increased to 7.4% for the emitter temperature of 1200 °C.
Crystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibiotic (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibioticMasataka Konishi, Hiroaki Ohkuma, Takashi Tsuno, Toshikazu Oki, Gregory D. VanDuyne, and Jon ClardyCite this: J. Am. Chem. Soc. 1990, 112, 9, 3715–3716Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ja00165a097https://doi.org/10.1021/ja00165a097research-articleACS PublicationsRequest reuse permissionsArticle Views1056Altmetric-Citations396LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Addition/elimination in the rhodium(II) perfluorobutyrate catalyzed hydrosilylation of 1-alkenes. Rhodium hydride promoted isomerization and hydrogenation (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition/elimination in the rhodium(II) perfluorobutyrate catalyzed hydrosilylation of 1-alkenes. Rhodium hydride promoted isomerization and hydrogenationMichael P. Doyle, Gene A. Devora, Andrei O. Nefedov, and Kenneth G. HighCite this: Organometallics 1992, 11, 2, 549–555Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/om00038a008https://doi.org/10.1021/om00038a008research-articleACS PublicationsRequest reuse permissionsArticle Views606Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation (2003)

Ultraviolet (UV) irradiation of HeLa cells triggers an apoptotic response mediated by mitochondria. Biochemical analysis of this response revealed that the elimination of cytosolic inhibitors is required for mitochondrial release of cytochrome c and subsequent caspase activation. These inhibitors were found to be Mcl-1 and Bcl-xL, two antiapoptotic members of the Bcl-2 family. Following UV treatment, Mcl-1 protein synthesis is blocked, the existing pool of Mcl-1 protein is rapidly degraded by the proteasome, and cytosolic Bcl-xL translocates to the mitochondria. These events are sequential; the elimination of Mcl-1 is required for the translocation of Bcl-xL. The disappearance of Mcl-1 is also required for other mitochondrial apoptotic events including Bax translocation, cytochrome c release, and caspase activation.
Endothelial dysfunction caused by University of Wisconsin preservation solution in the rat heart. The importance of temperature. (1992)

The superiority of the University of Wisconsin solution over routinely used crystalloid cardioplegic solutions for myocardial preservation has been demonstrated in animal studies. We have investigated the effect of the University of Wisconsin solution at different temperatures on endothelial function by examining its influence on 5-hydroxytryptamine- and nitroglycerin-induced increase in coronary flow in the isolated rat heart. Thirty-eight rat hearts were perfused on a modified Langendorff preparation. In the control experiments, there was no significant difference in the percentage increase in coronary flow induced by 5-hydroxytryptamine and nitroglycerin after 30 minutes of perfusion with Krebs-Henseleit buffer (n = 6). Continuous infusion of the University of Wisconsin solution for 30 minutes at 4 degrees C or at 10 degrees C did not alter the 5-hydroxytryptamine or nitroglycerin response. However, infusion at 15 degrees C reduced the 5-hydroxytryptamine-induced vasodilation, while at 20 degrees C the 5-hydroxytryptamine response was converted to vasoconstriction without a significant change in nitroglycerin effect (15 degrees C, 5-hydroxytryptamine, before: 30.2% +/- 1.5%, after: 6.0% +/- 1.0%, nitroglycerin, before: 28.8% +/- 1.3%, after: 31.2% +/- 1.8%; 20 degrees C, 5-hydroxytryptamine, before: 32.2% +/- 2.5%, after: -23.8% +/- 3.6%, nitroglycerin, before: 30.3% +/- 1.9%, after: 33.5% +/- 1.7%). Coronary vascular resistance in the control experiments rose from 55.0 +/- 2.5 cm H2O/ml/gm/min to 58.4 +/- 2.3 cm H2O/ml/gm/min (p = not significant). The increase after University of Wisconsin solution infusion at 4 degrees C and at 10 degrees C was similarly not significant. Coronary vascular resistance increased significantly following infusion of University of Wisconsin solution at 15 degrees C (p < 0.001) or at 20 degrees C (p < 0.01). We conclude that University of Wisconsin solution produces temperature-dependent endothelial dysfunction in the isolated rat heart.
Phaseguides: a paradigm shift in microfluidic priming and emptying (2011)

Phaseguide technology gives complete control over filling and emptying of any type of microfluidic structures, independent of the chamber and channel geometry. The technique is based on a step-wise advancement of the liquid-air interface using the meniscus pinning effect. In this paper, the main effects and parameters underlying the phaseguiding principle are discussed and a demonstration is given of its potential for dead angle filling, spatially controlled phaseguide overflow and sequential phaseguide overflow, all accumulating in a passive valving approach. Phaseguides represent a new direction in microfluidic design thinking that will prove a leap forward towards more simple, flexible and reliable microfluidic systems.
Preparation of highly monodisperse droplet in a T‐junction microfluidic device (2006)

Abstract In our previous work, a new flow route was developed—a so‐called perpendicular shear force–induced droplet formation—in a self‐designed simple T‐junction microchannel device. In this work, the crossflowing rupture technique was used to prepare monodisperse droplets in a similar device and successfully prepared monodisperse droplets ranging from 50 to 500 μm with polydispersity index (σ) values of &lt;2%. Two kinds of flow patterns of plug flow and drop flow in the T‐junction microchannels could be formed. By changes in the surfactant concentration, the interfacial tension and the wetting ability varied, and the disordered or ordered two‐phase flow patterns could be controlled. Evolutions of the contact angle of the oil in contact with the wall surface were explained by the adsorption of surfactant molecules to the solid–liquid interface. The increase of continuous phase flow rate and viscosity resulted in the decrease of the droplet size, and the droplet size was correlated with capillary number Ca. By comparing the variation range of drop size using the two methods, it was found that the method of perpendicular flow‐induced droplet formation can control the drop size over a much wider range. © 2006 American Institute of Chemical Engineers AIChE J, 2006
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis (2008)

Impaired function/differentiation of progenitor cells might provide an explanation for the limited remyelination observed in the majority of chronic multiple sclerosis lesions. Here, we establish that in the normal adult human CNS, the transcription factors Nkx2.2 and Olig2 are strongly expressed in progenitor cells while mature oligodendrocytes are characterized by low levels of Olig2 or Nkx2.2. In vitro studies confirmed the expression of Olig2 in oligodendroglial progenitor cells and mature oligodendrocytes while astrocytes, microglial cells and neurons were negative for Olig2. In early multiple sclerosis lesions, we found Olig2-positive progenitor cells throughout all lesion stages and in periplaque white matter (PPWM). The number of progenitors in PPWM was significantly increased compared with the white matter from controls. In chronic multiple sclerosis lesions progenitor cells were still present, however, in significantly lower numbers than in early multiple sclerosis lesions. A subpopulation of progenitor cells in early multiple sclerosis lesions and PPWM but not in control cases co-expressed NogoA, a marker of mature oligodendrocytes. The co-expression of these two markers suggested that these cells were maturing oligodendrocytes recently recruited from the progenitor pool. In contrast, in chronic multiple sclerosis lesions maturing progenitors were only rarely present. In summary, we provide evidence that a differentiation block of oligodendroglial progenitors is a major determinant of remyelination failure in chronic multiple sclerosis lesions.
Treatment of Breast Cancer (1998)

Breast cancer is a major public health problem worldwide. Management of breast cancer was last reviewed in the Journal in 1992.1 The accumulation of new biologic information, the results of recent clinical trials, and the availability of new diagnostic and therapeutic tools make it appropriate to review the subject again.EpidemiologyThe incidence of breast cancer in the United States has been increasing gradually for the past three decades.2,3 It was estimated that 181,600 new cases of breast cancer were diagnosed in the United States in 1997 and that 44,190 people would die of breast cancer during the same . . .
Design of Custom-Shaped Vascularized Tissues Using Microtissue Spheroids as Minimal Building Units (2006)

Tissue engineering strategies are gathering clinical momentum in regenerative medicine and are expected to provide excellent opportunities for therapy for difficult-to-treat human pathologies. Being aware of the requirement to produce larger artificial tissue implants for clinical applications, we used microtissues, produced using gravity-enforced self-assembly of monodispersed primary cells, as minimal tissue units to generate scaffold-free vascularized artificial macrotissues in custom-shaped agarose molds. Mouse myoblast, pig and human articular-derived chondrocytes, and human myofibroblast (HMF)-composed microtissues (microm3 scale) were amalgamated to form coherent macrotissue patches (mm3 scale) of a desired shape. Macrotissues, assembled from the human umbilical vein endothelial cell (HUVEC)-coated HMF microtissues, developed a vascular system, which functionally connected to the chicken embryo's vasculature after implantation. The design of scaffold-free vascularized macrotissues is a first step toward the scale-up and production of artificial tissue implants for future tissue engineering initiatives.
Über Dibenz[b,f]‐azocin‐Derivate (1966)

Abstract Aus o ‐Aminodibenzyl (I) und o ‐Amino‐ cis ‐stilben (IV) wurden mit Phosgen die Isocyanate II bzw. VIII hergestellt. Diese wurden als Harnstoffe V bzw. VII charakterisiert. Mit AlCl 3 in Dichlorbenzol behandelt, ging II in das Azocin III über, während aus VIII das Indolon IX entstand.
The Many Faces of Amyloid &#946; in Alzheimers Disease (2008)

The 'amyloid cascade hypothesis' links amyloid beta peptide (Abeta) with the pathological process of Alzheimer's disease (AD) and it still awaits universal acceptance. Amyloid precursor protein (APP), through the actions of the gamma-secretase complex, eventually becomes a different Abetaspecies. The various Abeta species have proven to be difficult to investigate under physiological conditions, and the species of Abeta responsible for neurotoxicity has yet to be unequivocally identified. The two important Abeta peptides involved are Abeta(1-40) and Abeta(1-42), and each has been ascribed both toxic and beneficial attributes. The ratio between the two species can be important in AD etiology. Additionally, shorter variants of Abeta peptides such as Abeta(1-8), Abeta(9-16) and Abeta(16) have also been shown to be potential participants in AD pathology. Interestingly, a new 56-kDa Abeta peptide (Abeta*56) disrupts memory when injected into the brains of young rats. Transgenic mice models are complicated by the interplay between various human Abeta types and the mouse Abeta types in the mouse brains. However, the accumulation of Abeta(1-42) in the brains of transgenic C. elegans worms and Drosophila is indeed detrimental. A less investigated aspect of AD is epigenetics, but in time the investigation of the role of epigenetics in AD may add to our understanding of the development of AD.
Chimeric anti-tumor necrosis factor-alpha monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy. (2000)

Infliximab is generally well tolerated during 40 weeks of therapy. A single infusion of 5 to 20 mg/kg infliximab significantly decreases the signs and symptoms of RA compared to placebo in patients with active disease receiving MTX. Multiple doses of infliximab produce sustained clinical benefit for up to 40 weeks.
CFTR Function and Prospects for Therapy (2008)

Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral membrane glycoprotein, a member of the adenine nucleotide-binding cassette (ABC) transporter family, conserved in metazoan salt-transporting tissues, is required to control ion and fluid homeostasis on epithelial surfaces. This review considers different therapeutic strategies that have arisen from knowledge of CFTR structure and function as well as its biosynthetic processing, intracellular trafficking, and turnover.