gebhart/patrepeval huggingface dataset:
Designing a value based niche search engine using evolutionary strategies (2005)

The advent of e-commerce and corporate intranets has led to the growth of organizational repositories containing large, fragmented, and unstructured document collections. Though it is difficult to retrieve relevant documents from such collections, it is relatively less cumbersome to define categories broadly classifying the information contained in the collection. Such categories lend value to the information contained in the collection. This research addresses the issue of improving retrieval accuracy of search engines that retrieve documents from organizational repositories using a value based approach. We test an evolutionary algorithm approach on a document collection. The precision of the search algorithm improved from 40% in generation 1 of the algorithm to nearly 90% in generation 10,000.
Contention Resolution Diversity Slotted ALOHA (CRDSA): An Enhanced Random Access Schemefor Satellite Access Packet Networks (2007)

In this paper a new multiple access scheme dubbed contention resolution diversity slotted ALOHA (CRDSA) is introduced and its performance and implementation are thoroughly analyzed. The scheme combines diversity transmission of data bursts with efficient interference cancellation techniques. It is shown that CRDSA largely outperforms the classical lotted ALOHA (SA) technique in terms of throughput under equal packet loss ratio conditions (e.g. 17-fold improvement at packet loss ratio = 2 middot 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ). CRDSA allows to boost the performance of random access (RA) channels in the return link of interactive satellite networks, making RA very efficient and providing low latency for the transmission of small size sparse packets. Implementation-wise it is shown that the CRDSA technique can be easily integrated in systems equipped with digital burst demodulators.
Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens (2002)

Cell-surface antigens provide invaluable tools for the identification of cells and for the analysis of cell differentiation. In particular, stage-specific embryonic antigens that are developmentally regulated during early embryogenesis are widely used as markers to monitor the differentiation of both mouse and human embryonic stem (ES) cells and their malignant counterparts, embryonic carcinoma (EC) cells. However, there are notable differences in the expression patterns of some such markers between human and mouse ES/EC cells, and hitherto it has been unclear whether this indicates significant differences between human and mouse embryos, or whether ES/EC cells correspond to distinct cell types within the early embryos of each species. We now show that human ES cells are characterized by the expression of the cell-surface antigens, SSEA3, SSEA4, TRA-1-60, and TRA-1-81, and by the lack of SSEA1, and that inner cell mass cells of the human blastocyst express a similar antigen profile, in contrast to the corresponding cells of the mouse embryo.
Complete purification and characterization of the taste-modifying protein, miraculin, from miracle fruit. (1988)

The taste-modifying protein, miraculin, has the unusual property of modifying a sour taste into a sweet taste. Previous attempts to isolate miraculin from deeply colored alkaline extracts of the miracle fruit were unsuccessful. We found that miraculin is extracted with 0.5 M NaCl solution. The extracted solution is colorless and shows the strong sweet-inducing activity. Miraculin was purified from the extracted solution by ammonium sulfate fractionation, CM-Sepharose ion-exchange chromatography, and concanavalin A-Sepharose affinity chromatography. The purified miraculin thus obtained gave a single sharp peak in reverse phase high performance liquid chromatography, indicating that it is highly pure. The sample also gave a single band having molecular weight 28,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. This value was much lower than the values reported previously (40,000-48,000). The amino acid composition of the purified miraculin was determined. Sequence analysis of the purified miraculin indicated that it is composed of a pure single polypeptide and identified 20 amino-terminal amino acids. The purified miraculin contained as much as 13.9% of sugars, which consisted of glucosamine, mannose, galactose, xylose, and fucose in a molar ratio of 3.03:3.00:0.69:0.96:2.12.
The Binding of Prototype Lexitropsins to the Minor Groove of DNA: Quantum Chemical Studies (1991)

Ab initio calculations (Hartree-Fock) using the 6-31 G basis set have been performed on two prototype lexitropsins or information-reading molecules. The latter are DNA minor groove binding agents related to the A.T recognizing netropsin in which each of the two N-methylpyrrole moieties is replaced in turn by 1-methylimidazole and which thereby confers the property of recognizing G.C sites.Ab initio treatment was possible by examining composities of separate non-conjugated segments of the molecules. Geometry optimized conformations, energies and distribution of electrostatic charges within the molecules were derived. The ab initio derived parameters of the geometry optimized conformations of these lexitropsins were used to interpret their interaction with different sequences within the minor groove of B-DNA.
Features of Porcine Circovirus-2 Disease: Correlations between Lesions, Amount and Distribution of Virus, and Clinical Outcome (2005)

Tissue sets from 36 snatch-farrowed colostrum-deprived (SF/CD) and 71 Caesarian-derived gnotobiotic swine infected with porcine circovirus type 2 (PCV-2) as neonates were examined and scored for the types and tissue distribution of histologic lesions associated with this viral infection. The occurrence and severity of these lesions were correlated with qualitative and quantitative determinations of viral burden in tissues by immunohistochemistry (IHC) and tissue titrations for infectious virus, respectively. These measures were, in turn, related to 1 of 3 categories of clinical disease expressed in PCV-2-infected swine as subclinical infection, preclinical postweaning multisystemic wasting syndrome (PMWS), and clinically evident PMWS, respectively. Statistically significant (P < 0.05 to 0.001) associations between both measures of viral burden, the severity of histologic lesions and the stage of disease were obtained. Discrimination between and among categories of disease was best accomplished by a combination of IHC and histopathology. The results of this study confirm that viral burden in PCV-2-infected tissues, specifically lymphoid tissues and liver, directly correlate with severity of clinical disease expression in PCV-2 infected swine.
A broadband self-healing phase synthesis scheme (2011)

This paper presents a full-range broadband phase synthesis scheme with autonomous phase correction functionality. The on-chip phase measurement is achieved by a set of on-chip LO self-/inter-mixing testing sequences, which eliminates the need for auxiliary test tones. As a design example, a 2-to-6GHz quadrature phase synthesis system in a 65nm CMOS is demonstrated. The phase self-healing scheme achieves an RMS phase error of less than 0.6° and a full 360° interpolation within the entire band.
Lower-stretch spanning trees (2005)

We show that every weighted connected graph G contains as a subgraph a spanning tree into which the edges of G can be embedded with average stretch O (log2 n log log n). Moreover, we show that this tree can be constructed in time O (m log2n) in general, and in time O (mlog n) if the input graph is unweighted. The main ingredient in our construction is a novel graph decomposition technique.Our new algorithm can be immediately used to improve the running time of the recent solver for symmetric diagonally dominant linear systems of Spielman and Teng from m2(O√lognlog log n) to m log O(1)n and to O (n log2n log log n) when the system is planar. Our result can also be used to improve several earlier approximation algorithms that use low-stretch spanning trees.
Fast depth of field rendering with surface splatting (2004)

We present a new fast algorithm for rendering the depth-of-field effect for point-based surfaces. The algorithm handles partial occlusion correctly, it does not suffer from intensity leakage and it renders depth-of-field in presence of transparent surfaces. The algorithm is new in that it exploits the level-of-detail to select the surface detail according to the amount of depth-blur applied. This makes the speed of the algorithm practically independent of the amount of depth-blur. The proposed algorithm is an extension of the elliptical weighted average (EWA) surface splatting. We present a mathematical analysis that extends the screen space EWA surface splatting to handle depth-of-field rendering with level-of-detail, and we demonstrate the algorithm on example renderings.
Lentivirus Display: Stable Expression of Human Antibodies on the Surface of Human Cells and Virus Particles (2008)

This antibody display platform will complement existing technologies by virtue of providing properties unique to lentiviruses and antibody expression in human cells, which, in turn, may aid the discovery of novel therapeutic human mAbs.
Discrimination of "Yes" and "No" Responses by Auditory Stimuli Multiple-choice Questions in Human EEG (2007)

Patients with severe physical disorders but who are cognitively intact find it difficult to communicate with the outside world. Researches on the brain-computer interface (BCI) are aimed to help such patients. This study analyzes the characteristics of brainwaves and classifies between "yes" and "no" responses when a subject thinks of a "yes" or "no" response to an auditory stimuli question. Experiment using auditory stimuli of the form of multiple-choice questions is performed. We discriminate between the activities of the brainwaves of the "yes" and "no" responses using the alpha power. Nineteen healthy subjects (7 females and 12 males), aged between 20 and 35 years, volunteered to participate in the experiments. In the experiment, for 17 out of 19 subjects (89.4%), the average alpha power for the "yes" response is greater than that for the "no" response. Also, Fisher's discriminant is performed to classify what the subject responses based on the average alpha power. 88.9% of original grouped cases (38 cases) and 83.3% of ungrouped cases (6 cases) are correctly classified.
The CRISPR/Cas9 system for gene editing and its potential application in pain research (2016)

The CRISPR/Cas9 system is a research hotspot in genome editing and regulation. Currently, it is used in genomic silencing and knock-in experiments as well as transcriptional activation and repression. This versatile system consists of two components: a guide RNA (gRNA) and a Cas9 nuclease. Recognition of a genomic DNA target is mediated through base pairing with a 20-base gRNA. The latter further recruits the Cas9 endonuclease protein to the target site and creates double-stranded breaks in the target DNA. Compared with traditional genome editing directed by DNA-binding protein domains, this short RNA-directed Cas9 endonuclease system is simple and easily programmable. Although this system may have off-target effects and <i>in vivo</i> delivery and immune challenges, researchers have employed this system <i>in vivo</i> to establish disease models, study specific gene functions under certain disease conditions, and correct genomic information for disease treatment. In regards to pain research, the CRISPR/Cas9 system may act as a novel tool in gene correction therapy for pain-associated hereditary diseases and may be a new approach for RNA-guided transcriptional activation or repression of pain-related genes. In addition, this system is also applied to loss-of-function mutations in pain-related genes and knockin of reporter genes or loxP tags at pain-related genomic loci. The CRISPR/Cas9 system will likely be carried out widely in both bench work and clinical settings in the pain field.
Induction of Epithelial Progenitors In Vitro from Mouse Embryonic Stem Cells and Application for Reconstruction of Damaged Cornea in Mice (2004)

Epithelial progenitors were successfully induced in vitro from ES cells and were applicable as grafts for treating corneal epithelial injury. ES cells may become an unlimited donor source of corneal epithelial cells for corneal transplantation and may restore useful vision in patients with a deficiency of limbal epithelial cells. This is an important first trial toward assessing the use of ES cells to reconstruct corneal epithelial cells.
Pictet-Spengler Reactions in Aprotic Media. Nb-Benzyl Promoted Retention of Optical Activity in the Synthesis of an Indole Substituted Azabicyclo[3.3.1]nonane, a Key Template for the Synthesis of Macroline Alkaloids (1988)

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Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. (1995)

Sonography can be used to accurately classify some solid lesions as benign, allowing imaging follow-up rather than biopsy.
Searching for information in a hypertext medical handbook (1987)

Effective information retrieval from large medical hypertext systems will require a combination of browsing and full-text document retrieval techniques. Using a prototype hypertext medical therapeutics handbook, I discuss one approach to information retrieval problems in hypertext. This approach responds to a query by initially treating each hypertext card as a full-text document. It then utilizes information about document structure to propagate weights to neighboring cards and produces a ranked list of potential starting points for graphical browsing.
Efficacy of Biventricular Sensing and Treatment of Ventricular Arrhythmias (2000)

While much is known concerning the hemodynamic effects of biventricular (BV) pacing, little has been reported concerning the efficacy of BV sensing and pacing in the detection and treatment of ventricular tachyarrhythmias. Two hundred nineteen heart failure (HF) patients with VT or VF and a QRS > or = 120 ms during sinus rhythm received an ICD capable of BV pacing and sensing. Detection times of induced VF and success rates for terminating induced VT were measured. The ICD system used a left ventricular epicardial lead implanted via thoracotomy (52 patients) or a specially designed percutaneous, over-the-wire lead inserted in the coronary venous system. VF detection times and VT termination rates by antitachycardia pacing (ATP) were compared with those measured in a population of recipients of ICD using a RV lead alone. Median induced VF detection times were comparable (2.0-s BV vs 1.8-s RV). Termination of induced VT on the first attempt was comparable with BV pacing (87.4%) versus RV pacing (89.6%). The time to detect induced VF was not different with ICDs using BV sensing versus conventional ICDs using RV sensing alone. Similarly, the rates of successful termination of induced VT by ATP with BV or RV pacing were comparable.
Fragmentation considered harmful (1995)

Internetworks can be built from many different kinds of networks, with varying limits on maximum packet size. Throughput is usually maximized when the largest possible packet is sent; unfortunately, some routes can carry only very small packets. The IP protocol allows a gateway to fragment a packet if it is too large to be transmitted. Fragmentation is at best a necessary evil; it can lead to poor performance or complete communication failure. There are a variety of ways to reduce the likelihood of fragmentation; some can be incorporated into existing IP implementations without changes in protocol specifications. Others require new protocols, or modifications to existing protocols.
Biomechanical Stability of Knotless Suture Anchors Used in Rotator Cuff Repair in Healthy and Osteopenic Bone (2010)

Anchor design and bone quality play important roles in the stability of the rotator cuff repair.
Cytoprotective agents for anthracyclines. (1996)

Anthracycline-induced cardiotoxicity is believed to be related to the generation of reactive oxygen species by at least two mechanisms: enzymatic reduction of the quinone with subsequent redox cycling and/or formation of an iron-anthracycline complex capable of intramolecular reduction and redox cycling. Both pathways may lead to the production of superoxide anions and highly reactive metabolites, such as hydroxyl radicals and hydrogen peroxide. As a result, membrane lipid peroxidation may ensue, producing damage in tissues like the heart, which have low antioxidant defenses (superoxide dismutase glutathione and especially, glutathione-peroxidase). Pharmacologic methods of interrupting this cycle have involved numerous antioxidants, such as the sulfhydryls N-acetylcysteine and cysteamine, and the lipophilic vitamin alpha tocopherol. Unfortunately, none of these compounds has been proven to be cardioprotective in patients receiving doxorubicin. In contrast, the water-soluble d-isomer of the iron chelator razoxane, dexrazoxane or ICRF-187, has been shown to reduce doxorubicin-induced cardiomyopathy. This has afforded greater cumulative doses of doxorubicin to be safely administered. The cytoprotective effect is apparently limited to the heart since there is no effect on antitumor efficacy and, unfortunately, no reduction in gastrointestinal toxicity, and with a slight increase in myelosuppression. More recent preclinical studies have also demonstrated cardioprotective activity for the aminothiol amifostine (WR-2721). In vitro, this agent has been shown to scavenge superoxide anions and hydroxyl radicals, the latter effect mediated by the active (dephosphorylated) metabolite, WR-1065. In tumor-bearing mice, amifostine reduces the lethality of high doses of doxorubicin without affecting antitumor activity. Finally, in vitro studies in neonatal rat heart cells have shown direct evidence of anthracycline cardioprotection for both amifostine and WR-1065. Cytoprotective drug levels of either agent were limited to 2.0 microg/mL, which is one tenth of the achievable peak plasma levels in humans. At this concentration, a 15-minute sulfhydryl pretreatment significantly prevented doxorubicin-induced depressions of myocyte adenosine triphosphate levels. Overall, these studies suggest that amifostine may have cytoprotective activity against doxorubicin-induced cardiac damage. Animal studies in a chronically dosed doxorubicin model are indicated; if positive, clinical trials testing this hypothesis will be warranted.
WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: The proline glycine and methionine-rich motif (1998)

Pre-mRNA splicing requires the bridging of the 5' and 3' ends of the intron. In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. Two of these WW domains, in the proteins FBP11 and FBP21, are strikingly similar to those found in the yeast splicing factor PRP40. We show that FBP21 is present in highly purified spliceosomal complex A, is associated with U2 snRNPs, and colocalizes with splicing factors in nuclear speckle domains. Moreover, FBP21 interacts directly with the U1 snRNP protein U1C, the core snRNP proteins SmB and SmB', and the branchpoint binding protein SF1/mBBP. Thus, FBP21 may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.
Control to realize human-like walking of a biped humanoid robot (2002)

The paper describes the balance control of biped locomotion systems. A biped humanoid robot is modeled and studied focusing on the realization of human-like walking. Firstly, the smooth motion of its lower limbs is characterized in terms of a set of walking variables. Secondly, to cancel moments produced by the motion of the lower limbs, the motion of its trunk and waist is derived by an iteration method. Finally, program control using a preset walking motion is applied to the biped robot. To confirm human-like walking, we have constructed a human-like biped robot called WABIAN-RII (WAseda BIped HumANoid robot-Revised II) that has a total of forty-three mechanical degrees of freedom (DOF). Experiments of a human-follow walking are conducted using the WABIAN-RII.
Differential expression of melanoma associated antigens in acral lentiginous melanoma and in nodular melanoma lesions. (1991)

The reactivity in an avidin-biotin complex immunoperoxidase reaction with a large panel of anti-human melanoma associated antigen (MAA) and anti-HLA monoclonal antibodies of 24 primary and 11 metastatic acral lentiginous melanoma (ALM) lesions was compared to that of 12 primary and 12 metastatic nodular melanoma (NM) lesions. The expression of the membrane bound vitronectin receptor, Mr 110,000 MAA, Mr 97,000 MAA, and intercellular adhesion molecule-1 was significantly lower in both primary and metastatic ALM lesions than in their NM counterparts. Furthermore, primary ALM lesions displayed a significantly lower expression than primary NM lesions of the membrane bound high molecular weight melanoma associated antigen (HMW-MAA), Mr 110,000 MAA, Mr 100,000 MAA, 9-O-acetyl-GD3, GD2-GD3, and GD2, of the cytoplasmic monoclonal antibody 465.12 defined MAA and of transferrin receptor and of HLA-DQ and DP antigens; ALM metastases expressed a significantly lower level of carcinoembryonic antigen-MAA than NM metastases. These antigenic differences do not reflect an antigenic paucity of ALM cells, since ALM lesions express a higher level of T4-tyrosinase than NM lesions and a level of HLA Class I antigens similar to that of NM lesions. In view of the use of HMW-MAA, Mr 97,000 MAA, and GD3 in immunoscintigraphy and/or in immunotherapy, it is noteworthy that the three antigens are expressed in a similar high percentage of ALM metastases and of primary and metastatic NM lesions, while the HMW-MAA is expressed in a markedly lower percentage of primary ALM lesions than Mr 97,000 MAA and GD3. However, the degree of heterogeneity of HMW-MAA within a positive primary ALM lesion, as measured by the percentage of stained melanoma cells, is lower than that of Mr 97,000 MAA and GD3. The expression of the antigens investigated in ALM and NM lesions was not correlated with the presence of lymphocyte infiltrates, melanin content of melanoma cells, and epithelioid and spindle type of melanoma cells in the lesions. On the other hand, the survival of patients with ALM was inversely correlated with the expression of intercellular adhesion molecule 1 or HMW-MAA in their primary lesions. A potential role of HMW-MAA in the course of the disease is suggested by its significantly higher expression in metastatic than in primary ALM lesions.(ABSTRACT TRUNCATED AT 400 WORDS)