gebhart/patrepeval huggingface dataset:
Characterization of Corrosion Inhibiting Emulsions for Continuous Well Treatment (1999)

Abstract Field experience has proven that water or oil-external emulsions containing properly formulated corrosion and scale inhibitors and cleaners, placed downhole in sufficient quantities, can provide more effective and long term well treatment than the frequently used oil-based products. The gradual break-up of emulsions due to the downhole shearing and heating conditions of wells yields a means of controlled release of the active ingredients present in these emulsions over a long period of time. The typical properties of corrosion inhibiting emulsions affecting the downhole placement of emulsions are measured and correlated by relevant theories. The mechanisms of the emulsion break-up and inhibitor release by various effects including shearing and heating are determined, formulated, and verified by experimental data~ The viscosity, drying and stability processes, surface tension and repetitive film coating on tubing and casing walls, inhibitor resolution and return profiles of the typical water and oil-external emulsions used in industry are correlated. A transient-state model for emulsion break-up and consumption, temperature, and the remaining and delivered inhibitor concentrations of downhole emulsion reservoirs is developed and verified by experimental data. This model is used to simulate typical scenarios and determine the sensitivity of the various parameters involved in well treatment.
TGF‐β signaling and the fibrotic response (2004)

The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic disease, it is essential to appreciate how matrix deposition is normally controlled and how this process is dysregulated in fibrogenesis. This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF, CCN2), and ED-A fibronectin (ED-A FN) and the antifibrotic proteins tumor necrosis factor-alpha (TNF-alpha) and gamma-interferon (IFN-gamma).
A Genetic Algorithm Approach to Farm Investment (1999)

A farm portfolio model is specified with two risky enterprises and a risk‐free asset which may be held short or long by the farmer. The model is solved numerically using a genetic algorithm. It is shown that the assumption of competitive adaptation leads to a violation of normative efficiency. Those who survive are not the most efficient in a normative sense.
The ancient and modern history of EM ground-wave propagation (1998)

Radio-wave transmission over the surface of the Earth is a subject of enquiry going back to the beginning of the century. In this review, an attempt is made to describe the ground-wave mechanism that is omni-present. We first call attention to the early analytical contributions of Zenneck and Sommerfeld, based on a flat-Earth model. The subsequent controversies, particularly with regard to the role of the Zenneck surface wave, are outlined. Further developments by other pioneers, such as van der Pol, Fock, Bremmer, Norton, and Millington, are reviewed, and an attempt is made to put these in a modern context. We also show that the trapped surface wave can be a significant contribution to the total ground-wave field, when the Earth boundary is sufficiently inductive. Mixed-path theory and confirming model tests by Ray King are described briefly, along with calculated propagation curves for twoand three-section paths. The bibliography includes references to related topics, such as tropospheric refraction and topographic influences.
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma (2019)

We report the initial toxicity profile of a BCMA-directed cellular immunotherapy for patients with relapsed or refractory multiple myeloma. Antitumor activity was documented. (Funded by Bluebird Bio and Celgene; CRB-401 ClinicalTrials.gov number, NCT02658929.).
Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at theIGL locus (2001)

Regulation of allelic and isotypic exclusion of human immunoglobulin (Ig) light-chain genes was studied in 113 chronic B-cell leukemias as a "single-cell" model that allowed complete analysis of each light chain allele. Our data show that monospecific Ig light chain expression is in about 90% of cases determined by ordered recombination: Igkappa gene (IGK) rearrangements, followed by IGK deletions and Iglambda gene (IGL) rearrangements, resulting in the presence of only one functional Ig light chain rearrangement. In about 10% (10 cases), 2 functional Ig light chain rearrangements (IGK/IGL or IGL/IGL, but not IGK/IGK) were identified. This might be explained by the fact that regulation of the ordered recombination process is not fully strict, particularly when the IGL locus is involved. Unfavorable somatic mutations followed by receptor editing might have contributed to this finding. Eight of these 10 cases indeed contained somatic mutations. In cases with 2 functional Ig light chain rearrangements, both alleles were transcribed, but monospecific Ig expression was still maintained. This suggests that in these cases allelelic exclusion is not regulated at the messenger RNA level but either at the level of translation or protein stability or via preferential pairing of Ig light and Ig heavy chains. Nevertheless, ordered rearrangement processes are the main determinant for monospecific Ig light chain expression.
Eculizumab in Severe Shiga-Toxin–Associated HUS (2011)

This letter reports treatment of three children with severe, dialysis-requiring Shiga-toxin–induced hemolytic–uremic syndrome (HUS) with eculizumab, a monoclonal anti-C5 antibody. The condition of all three children improved rapidly.
Adaptive integrated image segmentation and object recognition (2000)

The paper presents a general approach to image segmentation and object recognition that can adapt the image segmentation algorithm parameters to the changing environmental conditions. Segmentation parameters are represented by a team of generalized stochastic learning automata and learned using connectionist reinforcement learning techniques. The edge-border coincidence measure is first used as reinforcement for segmentation evaluation to reduce computational expenses associated with model matching during the early stage of adaptation. This measure alone, however, cannot reliably predict the outcome of object recognition. Therefore, it is used in conjunction with model matching where the matching confidence is used as a reinforcement signal to provide optimal segmentation evaluation in a closed-loop object recognition system. The adaptation alternates between global and local segmentation processes in order to achieve optimal recognition performance. Results are presented for both indoor and outdoor color images where the performance improvement over time is shown for both image segmentation and object recognition.
Practice Parameters for the Use of Laser-assisted Uvulopalatoplasty (1994)

This paper, which has been reviewed and approved by the Board of Directors of the American Sleep Disorders Association, provides the background for the Standards of Practice Committee's practice parameters for the practice of sleep medicine in North America. An office-based surgical procedure, laser-assisted uvulopalatoplasty (LAUP), has recently been promoted as a treatment for snoring. The American Sleep Disorders Association's Standards of Practice Committee reviewed the medical literature and developed practice parameters for the use of this operation. Adequate controlled studies regarding LAUP were not found in peer-reviewed journals; therefore, patients should be informed that the risks, benefits, and complications of this procedure have not been established. Because inadequate validation studies exist, prudence dictates that patients who elect this procedure undergo appropriate preoperative evaluation and postoperative follow-up.
Design and implementation of modular key management protocol and IP secure tunnel on AIX (1995)

This paper presents the design principles, architecture, implementation and performance of our modular key management protocol (MKMP) and an IP secure tunnel protocol (IPST) which protects the secrecy and integrity of IP datagrams using cryptographic functions. To use the existing IP infrastructure, MKMP is built on top of UDP and the IPST protocol is built by encapsulating IP datagrams.
Learning to Detect A Salient Object (2007)

We study visual attention by detecting a salient object in an input image. We formulate salient object detection as an image segmentation problem, where we separate the salient object from the image background. We propose a set of novel features including multi-scale contrast, center-surround histogram, and color spatial distribution to describe a salient object locally, regionally, and globally. A conditional random field is learned to effectively combine these features for salient object detection. We also constructed a large image database containing tens of thousands of carefully labeled images by multiple users. To our knowledge, it is the first large image database for quantitative evaluation of visual attention algorithms. We validate our approach on this image database, which is public available with this paper.
A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation (1991)

Long-term potentiation (LTP) of synaptic transmission is a widely studied model of neuronal plasticity. The induction of LTP is known to require processes in the postsynaptic neuron, while experimental evidence suggests that the expression of LTP may occur in the presynaptic terminal. This has led to speculation that a retrograde messenger travels from the post- to the presynaptic cell during induction of LTP. Extracellular application or postsynaptic injection of two inhibitors of nitric oxide synthase, N-nitro-L-arginine or NG-methyl-L-arginine, blocks LTP. Extracellular application of hemoglobin, which binds nitric oxide, also attenuates LTP. These findings suggest that nitric oxide liberated from postsynaptic neurons may travel back to presynaptic terminals to cause LTP expression.
Three‐Dimensional Polymer Constructs Exhibiting a Tunable Negative Poisson's Ratio (2011)

Young's modulus and Poisson's ratio of a porous polymeric construct (scaffold) quantitatively describe how it supports and transmits external stresses to its surroundings. While Young's modulus is always non-negative and highly tunable in magnitude, Poisson's ratio can, indeed, take on negative values despite the fact that it is non-negative for virtually every naturally occurring and artificial material. In some applications, a construct having a tunable negative Poisson's ratio (an auxetic construct) may be more suitable for supporting the external forces imposed upon it by its environment. Here, three-dimensional polyethylene glycol scaffolds with tunable negative Poisson's ratios are fabricated. Digital micromirror device projection printing (DMD-PP) is used to print single-layer constructs composed of cellular structures (pores) with special geometries, arrangements, and deformation mechanisms. The presence of the unit-cellular structures tunes the magnitude and polarity (positive or negative) of Poisson's ratio. Multilayer constructs are fabricated with DMD-PP by stacking the single-layer constructs with alternating layers of vertical connecting posts. The Poisson's ratios of the single- and multilayer constructs are determined from strain experiments, which show (1) that the Poisson's ratios of the constructs are accurately predicted by analytical deformation models and (2) that no slipping occurrs between layers in the multilayer constructs and the addition of new layers does not affect Poisson's ratio.
Dynamic service matchmaking among agents in open information environments (1999)

article Free Access Share on Dynamic service matchmaking among agents in open information environments Authors: Katia Sycara The Robotics Institute, Carnegie Mellon University, Pittsburgh The Robotics Institute, Carnegie Mellon University, PittsburghView Profile , Matthias Klusch The Robotics Institute, Carnegie Mellon University, Pittsburgh The Robotics Institute, Carnegie Mellon University, PittsburghView Profile , Seth Widoff The Robotics Institute, Carnegie Mellon University, Pittsburgh The Robotics Institute, Carnegie Mellon University, PittsburghView Profile , Jianguo Lu Computer Science Department, University of Toronto, CA. Computer Science Department, University of Toronto, CA.View Profile Authors Info & Claims ACM SIGMOD RecordVolume 28Issue 1March 1999 pp 47–53https://doi.org/10.1145/309844.309895Published:01 March 1999Publication History 209citation429DownloadsMetricsTotal Citations209Total Downloads429Last 12 Months39Last 6 weeks4 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Strong normalisation in the π-calculus (2002)

Introduces a typed /spl pi/-calculus where strong normalisation is ensured by typability. Strong normalisation is a useful property in many computational contexts, including distributed systems. In spite of its simplicity, our type discipline captures a wide class of converging name-passing interactive behaviours. The proof of strong normalisability combines methods from typed /spl lambda/-calculi and linear logic with process-theoretic reasoning. It is adaptable to systems involving state and other extensions. Strong normalisation is shown to have significant consequences, including finite axiomatisation of weak bisimilarity, a fully abstract embedding of the simply-typed /spl lambda/-calculus with products and sums and basic liveness in interaction. Strong normalisability has been extensively studied as a fundamental property in functional calculi, term rewriting and logical systems. This work is one of the first steps to extend theories and proof methods for strong normalisability to the context of name-passing processes.
Rate-Determining Steps in Phenacetin Oxidations by Human Cytochrome P450 1A2 and Selected Mutants (2000)

Mutants with altered activities were obtained from random libraries of human cytochrome P450 (P450) 1A2 with the putative substrate recognition sequences (SRS) mutated [Parikh, A., Josephy, P. D., and Guengerich, F. P. (1999) Biochemistry 38, 5283−5289]. Six mutants from SRS 2 (E225I, E225N, F226I, and F226Y) and 4 (D320A and V322A) regions were expressed as oligohistidine-tagged proteins, purified to homogeneity, and used to analyze kinetics of individual steps in the catalytic cycle, to determine which reaction steps have been altered. When the wild-type, E225I, E225N, F226I, F226Y, D320A, and V322A proteins were reconstituted with NADPH-P450 reductase, rates of 7-ethoxyresorufin O-deethylation and phenacetin O-deethylation were in accord with those expected from membrane preparations. Within each assay, the values of kcat/Km varied by 2−3 orders of magnitude, and in the case of E225I and E225N, these parameters were 7−8-fold higher than for the wild-type enzyme. The coupling efficiency obtained from the rates of product formation and NADPH oxidation was low (<20%) in all enzymes. No correlation was found between activities and several individual steps in the catalytic cycle examined, including substrate binding, reduction kinetics, NADPH oxidation, and H2O2 formation. Quench reactions did not show a burst for either phenacetin O-deethylation or formation of the acetol, a minor product, indicating that rate-determining steps occur prior to product formation. Inter- and intramolecular kinetic deuterium isotope effects for phenacetin O-deethylation were 2−3. In the case of phenacetin acetyl hydroxylation (acetol formation), large isotope effects [Dkcat or D(kcat/Km) > 10] were observed, providing evidence for rate-limiting C-H bond cleavage. We suggest that the very high isotope effect for acetol formation reflects rate-limiting hydrogen atom abstraction; the lower isotope effect for O-deethylation may be a consequence of a 1-electron transfer pathway resulting from the low oxidation potential of the substrate phenacetin. These pre-steady-state, steady-state, and kinetic hydrogen isotope effect studies indicate that the rate-limiting steps are relatively unchanged over an 800-fold range of catalytic activity. We hypothesize that these SRS mutations alter steps leading to the formation of the activated Michaelis complex following the introduction of the first electron.
Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease. (1993)

Human cord blood (CB) contains large numbers of both committed and primitive hematopoietic progenitor cells and has been shown to have the capacity to reconstitute the lympho-hematopoietic system in transplant protocols. To investigate the potential usefulness of CB stem and progenitor cell populations to deliver new genetic material into the blood and immune systems, we have transduced these cells using retroviral technology and compared the efficiency of gene transfer into CB cells with normal adult human bone marrow cells using a variety of infection protocols. Using two retroviral vectors which differ significantly in both recombinant viral titers and vector design, low density CB or adult bone marrow (ABM) cells were infected, and committed progenitor and more primitive hematopoietic cells were analyzed for gene expression by G418 drug resistance (G418r) of neophosphotransferase and protein analysis for murine adenosine deaminase (mADA). Standard methylcellulose progenitor assays were used to quantitate transduction efficiency of committed progenitor cells, and the long term culture-initiating cell (LTC-IC) assay was used to quantitate transduction efficiency of more primitive cells. Our results indicate that CB cells were more efficiently transduced via retroviral-mediated gene transfer as compared with ABM-derived cells. In addition, stable expression of the introduced gene sequences, including the ADA cDNA, was demonstrated in the progeny of infected LTC-ICs after 5 wk in long-term marrow cultures. Expression of the introduced ADA cDNA was higher than the endogenous human ADA gene in the LTC-IC-derived colonies examined. These studies demonstrate that CB progenitor and stem cells can be efficiently infected using retroviral vectors and suggest that CB cells may provide a suitable target population in gene transfer protocols for some genetic diseases.
A Two- or Three-Stage Bit-Rate Scalable Audio Coding System (1995)

While there are no really scalable audio coding systems known today in ISO MPEG scalability is an important requirement to support the new functionalities of MPEG-4. Scalability, in general, allows a subset of the bitstream to be decoded into a useful signal. This paper describes a two and three stage bit rate scaleable audio codec which combines speech coding an perceptual audio coding techniques with a specially adapted psychoacoustic model.
Polarization independent coherent optical receiver (1987)

This paper describes an optical heterodyne receiver for DPSK signals which can receive an optical signal having an arbitrary polarization state. This is achieved by splitting the received signal between two orthogonal polarization axes and processing the resulting two signals as in a conventional DPSK heterodyne receiver. The sum of the two demodulated signals provides a baseband signal independent of the polarization state of the received optical signal. When the receiver noise is dominated by the shot noise of the photodetectors, the receiver provides a BER of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> for an average number of 22 photon/bit. In comparison, a conventional optical heterodyne receiver requires under the same noise condition 20 photon/bit to achieve the same BER for a received optical signal polarized along the polarization axis of the local optical signal.
Globin gene expression in erythroid human fetal liver cells. (1989)

We measured steady-state levels of the human globin mRNAs in liver samples from several mid-gestational fetuses. RNA from the epsilon, gamma, beta, zeta, theta, and alpha globin genes were present in fetal liver samples isolated from 10-25-wk embryos. The abundance of all human globin mRNAs declined in older fetuses, presumably because of a gradual reduction in the proportion of erythroid precursors in the liver as development proceeds. The gamma:beta globin mRNA ratio in 10-18-wk fetal erythroblasts was 6-7:1, and in adult erythroid bone marrow the ratio was 0.02:1. In fetal liver samples, the relative abundance of epsilon transcripts was less than 1% that of gamma, and zeta transcripts less than 5% that of alpha. Embryonic transcripts declined in abundance during late fetal development and were not detected in newborn liver or adult erythroid bone marrow. theta globin mRNA also represented a minor species (less than 1% that of alpha) in fetal liver samples, but in contrast to the embryonic mRNAs, was most abundant in adult marrow samples obtained from patients with erythroid hyperplasia. These results support the hypothesis that globin protein levels are regulated by the relative amounts of each globin mRNA at various stages of erythropoietic development.
A tale of two functions: enzymatic activity and translational repression by carboxyltransferase (2009)

Acetyl-CoA Carboxylase catalyzes the first committed step in fatty acid synthesis. Escherichia coli acetyl-CoA carboxylase is composed of biotin carboxylase, carboxyltransferase and biotin carboxyl carrier protein functions. The accA and accD genes that code for the alpha- and beta-subunits, respectively, are not in an operon, yet yield an alpha(2)beta(2) carboxyltransferase. Here, we report that carboxyltransferase regulates its own translation by binding the mRNA encoding its subunits. This interaction is mediated by a zinc finger on the beta-subunit; mutation of the four cysteines to alanine diminished nucleic acid binding and catalytic activity. Carboxyltransferase binds the coding regions of both subunit mRNAs and inhibits translation, an inhibition that is relieved by the substrate acetyl-CoA. mRNA binding reciprocally inhibits catalytic activity. Preferential binding of carboxyltransferase to RNA in situ was shown using fluorescence resonance energy transfer. We propose an unusual regulatory mechanism by which carboxyltransferase acts as a 'dimmer switch' to regulate protein production and catalytic activity, while sensing the metabolic state of the cell through acetyl-CoA concentration.