gebhart/patrepeval huggingface dataset:
Synthesis, Crystal Structures and Photoluminescence of Mercury(II) Complexes with Two Homologous Novel Functional Rigid Ligands (2005)

Abstract Two novel functional rigid ligands, 2,2′‐ and 4,4′‐bipyridyl‐based “building blocks”, 9‐ethyl‐3,6‐bis[2‐(4‐pyridyl)ethenyl]carbazole ( L 1 ) and 9‐ethyl‐3,6‐bis[2‐(2‐pyridyl)ethenyl]carbazole ( L 2 ), were synthesized. Treatment of L 1 , 2 as “building blocks” with Hg(SCN) 2 or HgI 2 afforded helixes, macrocycles, and chains, which can be further self‐assembled by a π–π stacking interaction, hydrogen bond, and interatomic force in the solid state to form two‐dimensional networks. In complexes 1 – 4 , Hg II centers all adopt four‐coordination modes in different coordination environments, but they present different architectures with slightly adjusted structures of the ligands and counteranions, indicating that the nature of the ligand and anion plays an important role in the coordination networks. The luminescent properties of compounds 1 – 4 have been studied.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins (2009)

Guided by a combination of nuclear magnetic resonance binding assays and computational docking studies, we synthesized a library of 5,5' substituted Apogossypol derivatives as potent Bcl-XL antagonists. Each compound was subsequently tested for its ability to inhibit Bcl-XL in an in vitro fluorescence polarization competition assay and exert single-agent proapoptotic activity in human cancer cell lines. The most potent compound BI79D10 binds to Bcl-XL, Bcl-2, and Mcl-1 with IC50 values of 190, 360, and 520 nmol/L, respectively, and potently inhibits cell growth in the H460 human lung cancer cell line with an EC50 value of 680 nmol/L, expressing high levels of Bcl-2. BI79D10 also effectively induces apoptosis of the RS11846 human lymphoma cell line in a dose-dependent manner and shows little cytotoxicity against bax-/-bak-/- mouse embryonic fibroblast cells, in which antiapoptotic Bcl-2 family proteins lack a cytoprotective phenotype, implying that BI79D10 has little off-target effects. BI79D10 displays in vivo efficacy in transgenic mice, in which Bcl-2 is overexpressed in splenic B cells. Together with its improved plasma and microsomal stability relative to Apogossypol, BI79D10 represents a lead compound for the development of novel apoptosis-based therapies for cancer.
Differential current switch—High performance at low power (1991)

The recent IBM System/390™ announcement includes six high-performance air-cooled models that use a low-power variation of emitter-coupled logic (ECL). This new logic family, called differential current switch (DCS), uses differential signal pairs to represent logic signals, and combines two-level cascode logic with dotting to implement a complete set of logic circuits. These DCS circuits are described in detail, and the relative value of the DCS and ECL logic families is discussed extensively.
Intracellular Erythrocyte Platelet-activating Factor Acetylhydrolase I Inactivates Aspirin in Blood (2011)

Aspirin (acetylsalicylic acid) prophylaxis suppresses major adverse cardiovascular events, but its rapid turnover limits inhibition of platelet cyclooxygenase activity and thrombosis. Despite its importance, the identity of the enzyme(s) that hydrolyzes the acetyl residue of circulating aspirin, which must be an existing enzyme, remains unknown. We find that circulating aspirin was extensively hydrolyzed within erythrocytes, and chromatography indicated these cells contained a single hydrolytic activity. Purification by over 1400-fold and sequencing identified the PAFAH1B2 and PAFAH1B3 subunits of type I platelet-activating factor (PAF) acetylhydrolase, a phospholipase A(2) with selectivity for acetyl residues of PAF, as a candidate for aspirin acetylhydrolase. Western blotting showed that catalytic PAFAH1B2 and PAFAH1B3 subunits of the type I enzyme co-migrated with purified erythrocyte aspirin hydrolytic activity. Recombinant PAFAH1B2, but not its family member plasma PAF acetylhydrolase, hydrolyzed aspirin, and PAF competitively inhibited aspirin hydrolysis by purified or recombinant erythrocyte enzymes. Aspirin was hydrolyzed by HEK cells transfected with PAFAH1B2 or PAFAH1B3, and the competitive type I PAF acetylhydrolase inhibitor NaF reduced erythrocyte hydrolysis of aspirin. Exposing aspirin to erythrocytes blocked its ability to inhibit thromboxane A(2) synthesis and platelet aggregation. Not all individuals or populations are equally protected by aspirin prophylaxis, the phenomenon of aspirin resistance, and erythrocyte hydrolysis of aspirin varied 3-fold among individuals, which correlated with PAFAH1B2 and not PAFAH1B3. We conclude that intracellular type I PAF acetylhydrolase is the major aspirin hydrolase of human blood.
Treatment of Diabetic Gustatory Sweating with Topical Glycopyrrolate Cream (1996)

A 42-year-old insulin-dependent diabetic man presented with severe bilateral gustatory sweating associated with a deterioration in his glycaemic control. Conventional oral antimuscarinic medication was contraindicated because of his cardiac insufficiency. Topical 0.5% glycopyrrolate cream was tried and applied on alternate days to his face, which resulted in the complete cessation of his gustatory sweating without side-effects. Topical glycopyrrolate cream is an effective treatment of diabetic gustatory sweating without the adverse effects commonly found with oral anti-muscarinic medication.
Parachlamydiaceae: Potential Emerging Pathogens (2002)

Parachlamydiaceae, which naturally infect amoebae, form a sister taxon to the Chlamydiaceae on the basis of the Chlamydia-like cycle of replication and 80% to 90% homology of ribosomal RNA genes. Because intra-amoebal growth could increase the virulence of some intracellular bacteria, Parachlamydiaceae may be pathogenic. Arguments supporting a pathogenic role are that Chlamydia pneumoniae, a well-recognized agent of pneumonia, was shown to infect free-living amoebae and that another member of the Chlamydiales, Simkania negevensis, which has 88% homology with Parachlamydia acanthamoebae, has caused pneumonia in adults and acute bronchiolitis in infants. The recent identification of a 16S rRNA gene sequence of a Parachlamydiaceae from bronchoalveolar lavage is additional evidence supporting potential for pathogenicity.
Two-Dimensional Photonic Crystal Chemical and Biomolecular Sensors (2015)

We review recent progress in the development of two-dimensional (2-D) photonic crystal (PC) materials for chemical and biological sensing applications. Self-assembly methods were developed in our laboratory to fabricate 2-D particle array monolayers on mercury and water surfaces. These hexagonal arrays strongly forward Bragg diffract light to report on their array spacings. By embedding these 2-D arrays onto responsive hydrogel surfaces, 2-D PC sensing materials can be fabricated. The 2-D PC sensors utilize responsive polymer hydrogels that are chemically functionalized to show volume phase transitions in selective response to particular chemical species. Novel hydrogels were also developed in our laboratory by cross-linking proteins while preserving their native structures to maintain their selective binding affinities. The volume phase transitions swell or shrink the hydrogels, which alter their 2-D array spacings, and shift their diffraction wavelengths. These shifts can be visually detected or spectrally measured. These 2-D PC sensing materials have been used for the detection of many analytes, such as pH, surfactants, metal ions, proteins, anionic drugs, and ammonia. We are exploring the use of organogels that use low vapor pressure ionic liquids as their mobile phases for sensing atmospheric analytes.
Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance (1999)

We have previously reported the identification of the endogenous angiogenesis inhibitor angiostatin, a specific inhibitor of endothelial cell proliferation in vitro and angiogenesis in vivo. In our original studies, we demonstrated that a Lewis lung carcinoma (LLC-LM) primary tumor could suppress the growth of its metastases by generating angiostatin. Angiostatin, a 38-kDa internal fragment of plasminogen, was purified from the serum and urine of mice bearing LLC-LM, and its discovery provides the first proven mechanism for concomitant resistance (O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M. A., Lane, W. S., Cao, Y., Sage, E. H., and Folkman, J. (1994) Cell 79, 315-328). Subsequently, we have shown that systemic administration of angiostatin can regress a wide variety of malignant tumors in vivo. However, at the time of our initial discovery of angiostatin, the source of the protein was unclear. We hypothesized that the tumor or stromal cells might produce an enzyme that could cleave plasminogen sequestered by the primary tumor into angiostatin. Alternatively, we speculated that the tumor cells might express angiostatin. By Northern analysis, however, we have found no evidence that the tumor cells express angiostatin or other fragments of plasminogen (data not shown). We now report that gelatinase A (matrix metalloproteinase-2), produced directly by the LLC-LM cells, is responsible for the production of angiostatin, which suppresses the growth of metastases in our original model.
On Duality between Filtering and Interpolation (1997)

This paper is a survey on the rational covariance extension problem, a problem with historical roots in the beginning of the century going back to work by Carathéodory, Toeplitz and Schur on interpolation [20, 21, 60, 59]. Carathéodory’s interest was in classifying all bounded harmonic functions with prescribed first n derivatives at a given point, such as ∞ in our analysis. This problem was also studied by Toeplitz [60] and Schur [59], who was able to develop a complete parameterization of the class of such interpolants defining meromorphic functions υ(z) which are strictly positive real. From the perspective of classical analysis, however, the question of which meromorphic interpolants were rational would not have played a major role.
Resolving tag ambiguity (2008)

Tagging is an important way for users to succinctly describe the content they upload to the Internet. However, most tag-suggestion systems recommend words that are highly correlated with the existing tag set, and thus add little information to a user's contribution. This paper describes a means to determine the ambiguity of a set of (user-contributed) tags and suggests new tags that disambiguate the original tags. We introduce a probabilistic framework that allows us to find two tags that appear in different contexts but are both likely to co-occur with the original tag set. If such tags can be found, the current description is considered "ambiguous" and the two tags are recommended to the user for further clarification. In contrast to previous work, we only query the user when information is most needed and good suggestions are available. We verify the efficacy of our approach using geographical, temporal and semantic metadata, and a user study. We built our system using statistics from a large (100M) database of images and their tags.
Strongly enhanced static friction using a film-terminated fibrillar interface (2008)

We examine the behavior under shear of a bio-inspired fibrillar interface that consists of poly(dimethlysiloxane) micro-posts terminated by a thin film. These structures demonstrate significantly enhanced adhesion due to a crack trapping mechanism. We study the response of this structure to shear displacement relative to a spherical indenter placed on its surface under a fixed normal force. The shear force required to initiate sliding between the indenter and the sample, its static friction, is strongly enhanced compared to a flat control, and increases with inter-fibril spacing. Examination of the contact region reveals that its area changes with applied shear and that static friction is controlled by a mechanical instability. The shear force resisting steady sliding, surprisingly, is independent of fibril spacing and is nearly the same as for the flat unstructured control samples. We interpret dynamic friction to result from the action of Schallamach-like waves. Our results show that the film-terminated architecture can be used to design an interface with significantly enhanced static friction without altering its sliding frictional resistance.
Development of a Wilms' tumor antigen-specific T-cell receptor for clinical trials: engineered patient's T cells can eliminate autologous leukemia blasts in NOD/SCID mice (2009)

This is the first report that patient's T cells, engineered to express the WT1-T-cell receptor, can eliminate autologous leukemia progenitor cells in an in vivo model. This study provides a firm basis for the planned WT1-T-cell receptor gene therapy trial in leukemia patients.
Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer (2002)

None of four chemotherapy regimens offered a significant advantage over the others in the treatment of advanced non-small-cell lung cancer.
The Feasibility of a Smart Surgical Probe for Verification of IRE Treatments Using Electrical Impedance Spectroscopy (2015)

This technique has the potential to be readily translated for use with other ablation modalities already being used in clinical settings for the treatment of malignancies.
Conferring Operator Specificity on Restriction Endonucleases (1988)

Mapping and manipulation of very large genomes, including the human genome, would be facilitated by the availability of a DNA cleavage method with very high site specificity. Therefore, a general method was devised that extends the effective recognition sequences well beyond the present 8-base pair limit by combining the specificity of the restriction endonuclease with that of another sequence-specific protein that binds tightly to DNA. It was shown that the tightly binding lac or lambda repressor protects a restriction site within the operator from specific modification methylases, M.Hha I or M.Hph I, while all other similar sites are methylated and thus rendered uncleavable. A plasmid containing a symmetric lac operator was specifically cleaved by Hha I, only at the site within the operator, after M.Hha I methylation in the presence of the lac repressor, whereas the remaining 31 Hha I sites on this plasmid were methylated and thus not cleaved. Analogous results were obtained with the Hae II site within the lac operator, which was similarly protected by the lac repressor, and with the Hph I site within the phage lambda oL operator, which was protected by lambda repressor from M.Hph I methylation.
HYBRID NEURAL NETWORK/HIDDEN MARKOV MODEL SYSTEMS FOR CONTINUOUS SPEECH RECOGNITION (1993)

MultiLayer Perceptrons (MLP) are an effective family of algorithms for the smooth estimation of highly-dimensioned probability density functions that are useful in continuous speech recognition. Hidden Markov Models (HMM) provide a structure for the mapping of a temporal sequence of acoustic vectors to a generating sequence of states. For HMMs that are independent of phonetic context, the MLP approaches have consistently provided significant improvements (once we learned how to use them). Recently, these results have been extended to context-dependent models. In this paper, after having reviewed the basic principles of our hybrid HMM/MLP approach, we describe a series of experiments with continuous speech recognition. The hybrid methods directly trade off computational complexity for reduced requirements of memory and memory bandwidth. Results are presented on the widely used Resource Management speech database that is distributed by the National Institute of Standards and Technology. These results demonstrate performance that is at least as good as any other reported continuous speech recognition system (for this task).
The Preparation of Mercaptans from Alcohols1 (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Mercaptans from Alcohols1Robert L. Frank and Paul V. SmithCite this: J. Am. Chem. Soc. 1946, 68, 10, 2103–2104Publication Date (Print):October 1, 1946Publication History Published online1 May 2002Published inissue 1 October 1946https://pubs.acs.org/doi/10.1021/ja01214a505https://doi.org/10.1021/ja01214a505research-articleACS PublicationsRequest reuse permissionsArticle Views1355Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ricin A chain utilises the endoplasmic reticulum‐associated protein degradation pathway to enter the cytosol of yeast (1999)

Cytotoxic proteins such as ricin A chain (RTA) have target substrates in the cytosol and therefore have to reach this cellular compartment in order to act. RTA is thought to translocate into the cytosol from the lumen of the endoplasmic reticulum (ER), although how it traverses the ER membrane has not been established. Using yeast mutants defective in various aspects of the ER-associated protein degradation (ERAD) pathway, we show that RTA introduced into the yeast ER subverts this pathway to enter the cytosol via the Sec61p translocon. A significant proportion of the exported RTA avoided proteasomal degradation. These data are consistent with the contention that the RTA component from ricin endocytosed by mammalian cells may likewise exploit ERAD to translocate into the cytosol.
Regioselective catalytic hydrogenation of polycyclic aromatic hydrocarbons under mild conditions (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRegioselective catalytic hydrogenation of polycyclic aromatic hydrocarbons under mild conditionsPeter P. Fu, Hong M. Lee, and Ronald G. HarveyCite this: J. Org. Chem. 1980, 45, 14, 2797–2803Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/jo01302a010https://doi.org/10.1021/jo01302a010research-articleACS PublicationsRequest reuse permissionsArticle Views882Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lentiviral Vectors for Cancer Immunotherapy and Clinical Applications (2013)

The success of immunotherapy against infectious diseases has shown us the powerful potential that such a treatment offers, and substantial work has been done to apply this strategy in the fight against cancer. Cancer is however a fiercer opponent than pathogen-caused diseases due to natural tolerance towards tumour associated antigens and tumour-induced immunosuppression. Recent gene therapy clinical trials with viral vectors have shown clinical efficacy in the correction of genetic diseases, HIV and cancer. The first successful gene therapy clinical trials were carried out with onco(γ-)retroviral vectors but oncogenesis by insertional mutagenesis appeared as a serious complication. Lentiviral vectors have emerged as a potentially safer strategy, and recently the first clinical trial of patients with advanced leukemia using lentiviral vectors has proven successful. Additionally, therapeutic lentivectors have shown clinical efficacy for the treatment of HIV, X-linked adrenoleukodystrophy, and β-thalassaemia. This review aims at describing lentivectors and how they can be utilized to boost anti-tumour immune responses by manipulating the effector immune cells.
Clinical applications of colony-stimulating factors: A historical perspective (2002)

The development of the therapeutic roles of filgrastim and sargramostim over the past decade is reviewed. Filgrastim, a recombinant granulocyte colony-stimulating factor (G-CSF), and sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF), have been available in the United States for over a decade to treat various types of neutropenia. In addition, data are available to support their use in a variety of clinical settings. Because of the high cost of these agents, clinical guidelines for their appropriate use have been developed. With respect to the comparability of filgrastim and sargramostim, the American Society of Clinical Oncology recommends that additional data be generated since current data are insufficient to adequately address this question in each clinical setting. A limited number of randomized, comparative trials have directly compared filgrastim with sargramostim. Outcomes data from these trials are reviewed. Further, there is evidence to suggest that, at least for GM-CSF, tolerability is dependent on the degree of protein glycosylation. A nonglycosylated protein, molgramostim, available in Europe appears to be associated with greater toxicity in clinical trials, although randomized comparative trials are lacking. The therapeutic equivalence of CSFs requires further study. While data show that the efficacy and tolerability of CSFs are similar in certain settings, there has been no definitive, randomized, large-scale clinical trial conducted to address this issue. Pharmacists should continue to evaluate clinical data to determine not only which CSF to use but also when a CSF should be used.
Fungal infections of the immunocompromised host: clinical and laboratory aspects. (1988)

Fungal infections of the immunocompromised host are being seen with greater frequency than ever before. In addition, a growing list of unusual and unexpected etiologic agents presents a unique and difficult challenge to the clinician and microbiologist. The clinical manifestations of opportunistic fungal infections are often not characteristic and, in many instances, may prevent a rapid diagnosis from being made. Clinical microbiology laboratories should consider any organism as a potential etiologic agent. This requires that all fungi recovered from immunocompromised patients be thoroughly identified and reported so that their clinical significance may be assessed. This review presents a brief discussion of the clinical and laboratory aspects of some fungal infections seen in this important group of patients.