gebhart/patrepeval huggingface dataset:
Data-Free Knowledge Distillation for Deep Neural Networks (2017)

Recent advances in model compression have provided procedures for compressing large neural networks to a fraction of their original size while retaining most if not all of their accuracy. However, all of these approaches rely on access to the original training set, which might not always be possible if the network to be compressed was trained on a very large dataset, or on a dataset whose release poses privacy or safety concerns as may be the case for biometrics tasks. We present a method for data-free knowledge distillation, which is able to compress deep neural networks trained on large-scale datasets to a fraction of their size leveraging only some extra metadata to be provided with a pretrained model release. We also explore different kinds of metadata that can be used with our method, and discuss tradeoffs involved in using each of them.
The Natural History of Antisocial Personality Disorder (2015)

Antisocial personality disorder (ASPD) is characterized by a pattern of socially irresponsible, exploitative, and guiltless behaviour. ASPD is associated with co-occurring mental health and addictive disorders and medical comorbidity. Rates of natural and unnatural death (suicide, homicide, and accidents) are excessive. ASPD is a predictor of poor treatment response. ASPD begins early in life, usually by age 8 years. Diagnosed as conduct disorder in childhood, the diagnosis converts to ASPD at age 18 if antisocial behaviours have persisted. While chronic and lifelong for most people with ASPD, the disorder tends to improve with advancing age. Earlier onset is associated with a poorer prognosis. Other moderating factors include marriage, employment, early incarceration (or adjudication during childhood), and degree of socialization.
Ideal Distortion-Free Transmission Using Optical Fourier Transformation and Fourier Transform-Limited Optical Pulses (2004)

A new scheme for undistorted ideal pulse transmission is proposed that uses optical Fourier transformation (OFT) and transform-limited (TL) pulses. The technique focuses on the unchanged spectrum of the Fourier TL pulse after transmission, and at the output we convert the unchanged spectrum to the time domain using OFT. The transformed waveform in the time domain has no distortion. To show the effectiveness of this technique, we undertook a third-order dispersion elimination experiment. The results agree well with the theory.
Performance and dependability of structured peer-to-peer overlays (2004)

Structured peer-to-peer (P2P) overlay networks provide a useful substrate for building distributed applications. They map object keys to overlay nodes and offer a primitive to send a message to the node responsible for a key. They can implement, for example, distributed hash tables and multicast trees. However, there are concerns about the performance and dependability of these overlays in realistic environments. Several studies have shown that current P2P environments have high churn rates: nodes join and leave the overlay continuously. This paper presents techniques that continuously detect faults and repair the overlay to achieve high dependability and good performance in realistic environments. The techniques are evaluated using large-scale network simulation experiments with fault injection guided by real traces of node arrivals and departures. The results show that previous concerns are unfounded; our techniques can achieve dependable routing in realistic environments with an average delay stretch below two and a maintenance overhead of less than half a message per second per node.
Gender Representations and Digital Media (2015)

The construction of gender goes on today through various technologies of gender (e.g. cinema) and individual discourses (e.g. theory) with the power to control the field of social meaning and thus produce, promote, and ‘implant’ representations of gender. Digital media had and has even now an immense growing through the media consumption. The need to study ‘whose voices are being heard in digital media’ passes from typically portrayed media (especially advertising and television) gender-specific items– men with alcohol, vehicles, or business products, women associated with domestic products to the position of women as media professionals or news actors. Our research tries to identify some of the new gender images in online media, by news content analysis. Being aware of the impact of the news industries on our cultural, political, and social lives, we have chosen to focus our study on how texts operate to produce meanings which reproduce dominant ideologies of gender in digital media news.
Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells (2011)

Neuroblastoma (NB) is an often fatal pediatric tumor of neural crest origin. We previously isolated NB tumor-initiating cells (NB TIC) from bone marrow metastases that resemble cancer stem cells and form metastatic NB in immunodeficient animals with as few as ten cells. To identify signaling pathways important for the survival and self-renewal of NB TICs and potential therapeutic targets, we screened a small molecule library of 143 protein kinase inhibitors, including 33 in clinical trials. Cytostatic or cytotoxic drugs were identified that targeted PI3K (phosphoinositide 3-kinase)/Akt, PKC (protein kinase C), Aurora, ErbB2, Trk, and Polo-like kinase 1 (PLK1). Treatment with PLK1 siRNA or low nanomolar concentrations of BI 2536 or BI 6727, PLK1 inhibitors in clinical trials for adult malignancies, were cytotoxic to TICs whereas only micromolar concentrations of the inhibitors were cytotoxic for normal pediatric neural stem cells. Furthermore, BI 2536 significantly inhibited TIC tumor growth in a therapeutic xenograft model, both as a single agent and in combination with irinotecan, an active agent for relapsed NB. Our findings identify candidate kinases that regulate TIC growth and survival and suggest that PLK1 inhibitors are an attractive candidate therapy for metastatic NB.
Further Characterization of HeLa DNA Polymerase ∊ (1995)

DNA polymerase epsilon (pol epsilon) from HeLa cells was purified to near homogeneity, utilizing Mono S fast protein liquid chromatography for complete separation from pol alpha. The purified pol epsilon preparation showed two polypeptides of > 200 and 55 kDa and a small amount of active 122-kDa proteolysis product on denaturing polyacrylamide gels. Pol epsilon (as well as pols alpha and delta) is optimally active in 100-150 mM potassium glutamate and 15 mM MgCl2. Replication factors RF-A and RF-C, proliferating cell nuclear antigen, and Escherichia coli single-stranded DNA binding protein showed no significant effect on this preparation's pol epsilon activity, processivity, or substrate specificity. The size of the pol epsilon transcript for the catalytic subunit (> 200 kDa) was investigated in both normal human fibroblasts and HeLa cells. A 7.7-kilobase transcript was detected which was 5-16-fold more prevalent in proliferating than in quiescent HeLa cells. No significant difference in the level of pol epsilon transcript in HeLa cells or fibroblasts was seen after ultraviolet irradiation. Mouse polyclonal antiserum was produced to a 144-amino acid fragment of pol epsilon fused to staphylococcal protein A. This non-neutralizing polyclonal antiserum specifically recognized the catalytic subunit of pol epsilon by immunoblotting, but not that of pol alpha, beta, or delta. In addition, mouse polyclonal antiserum raised against column-purified pol epsilon was able to recognize and to neutralize pol epsilon, and a mouse monoclonal antibody was raised which was able to recognize specifically the catalytic subunit of pol epsilon.
Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis (1999)

With cDNA microarrays, it is now possible to compare the expression of many genes simultaneously. To maximize the likelihood of finding genes whose expression is altered under the experimental conditions, it would be advantageous to be able to select clones for tissue-appropriate cDNA sets. We have taken advantage of the extensive sequence information in the dbEST expressed sequence tag (EST) database to identify a neural crest-derived melanocyte cDNA set for microarray analysis. Analysis of characterized genes with dbEST identified one library that contained ESTs representing 21 neural crest-expressed genes (library 198). The distribution of the ESTs corresponding to these genes was biased toward being derived from library 198. This is in contrast to the EST distribution profile for a set of control genes, characterized to be more ubiquitously expressed in multiple tissues (P < 1 x 10(-9)). From library 198, a subset of 852 clustered ESTs were selected that have a library distribution profile similar to that of the 21 neural crest-expressed genes. Microarray analysis demonstrated the majority of the neural crest-selected 852 ESTs (Mel1 array) were differentially expressed in melanoma cell lines compared with a non-neural crest kidney epithelial cell line (P < 1 x 10(-8)). This was not observed with an array of 1,238 ESTs that was selected without library origin bias (P = 0.204). This study presents an approach for selecting tissue-appropriate cDNAs that can be used to examine the expression profiles of developmental processes and diseases.
NMDA Receptors in Layer 4 Spiny Stellate Cells of the Mouse Barrel Cortex Contain the NR2C Subunit (2006)

In layer 4 of the somatosensory cortex, the glutamatergic synapses that interconnect spiny stellate (SpS) neurons, which are the major targets of thalamocortical input, differ from most other neocortical excitatory synapses in that they have an extremely large NMDA receptor (NMDAR)-mediated component that is relatively insensitive to voltage-dependent Mg2+ blockade. We now report that this unique feature of the NMDA response reflects the distinctive subunit composition of the underlying receptors. We studied NMDAR-mediated miniature EPSCs (mEPSCs) and NMDA channel currents in tangential brain slices of mouse barrel cortex, which exclusively contain layer 4. NMDAR-mediated mEPSCs in SpS neurons were prominent at negative membrane potentials, and NMDA channels in outside-out patches excised from the somata of the same neurons had relatively low conductance and reduced susceptibility to Mg2+ block. These are characteristic features of heteromeric NMDAR assemblies that contain the NR2C subunit. Some patches also contained NMDA channels with higher conductance and a greater sensitivity to Mg2+. In the neocortex of transgenic mice in which a beta-galactosidase (lacZ) indicator gene was controlled by the NR2C promoter, the lacZ indicator was densely expressed in layer 4. In current-clamp recordings, blockade of NMDARs caused hyperpolarization and an increase in apparent input resistance. Our data demonstrate that the SpS neurons of layer 4 functionally express NR2C subunits; this is the likely explanation for their ability to generate large NMDAR-mediated EPSPs that are effective at resting potential, without previous depolarization.
Hedgehog Signaling Pathway in Ovarian Cancer (2013)

Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
ACE- Versus Chymase-Dependent Angiotensin II Generation in Human Coronary Arteries (2003)

Both ACE and chymase contribute to the generation of functionally active angiotensin II in HCAs. However, because angiotensin II loss in the organ bath is chymase-dependent, ACE-mediated conversion occurs more efficiently (ie, closer to AT(1) receptors) than chymase-mediated conversion.
New Biomimetic HA coatings (1996)

The formation of an apatite-like layer was achieved by immersing Ti-61-4V, Ti-A1-2.5Fe and 316 L stainless steel substrata in Hank's balanced salt solution (HBSS). The layer was characterized by surface analysis techniques, namely X-ray microanalysis and X-ray diffraction, and the morphology was observed by scanning electron microscopy and atomic force microscopy. The concentrations of Ca and P were monitored as a function of time.
Demonstration and minimization of serum interference in flow cytometric two-site immunoassays. (1994)

The ability of serum factors to cross-link labeled mouse monoclonal antibody (mAb) of irrelevant specificity (mAb FN61, subclass IgG1) to different particle types coated with sheep IgG, bovine gamma-globulin, or mAb FN61 was measured simultaneously by flow cytometry. Significant interference with mAb FN61-coated particles was detected in 53 of 101 sera. Of the 30 sera showing the most pronounced interference, 23 were characterized by an even stronger cross-linking to particles coated with bovine gamma-globulin. These were designated type 1 sera. Seven sera, designated type 2, displayed a dominant interference with the mAb FN61-coated particles. The interference reaction in the two serum types was characterized by different kinetics, dependence on particle concentration, and response to blocking agents. The interference was minimized by addition of 500 micrograms of bovine gamma-globulin and 50 micrograms of mAb HH1 (IgG1) of irrelevant specificity per 10 microL of serum sample in a final assay volume of 100 microL.
Long Short-Term Memory (1997)

Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.
From Iowa to Finland and Back (1990)

When I enrolled in the forestry curriculum at Iowa State University, I knew that a vast number of opportunities would be available to me. However, I never expected to have the once in a lifetime opportunity that I experienced during the summer of 1989.
Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties. (1987)

Protein kinase C (Ca2+/phospholipid-dependent protein kinase) purified from rat brain or endogenous to cell-free extracts from HeLa cells stimulates, by a factor of 2-3, HeLa DNA polymerase alpha but not beta or gamma. Monoclonal antibody to the kinase prevents the stimulation, and monoclonal antibody to human DNA polymerase alpha neutralizes the enhanced activity. Reduced DNA polymerase alpha activity is obtained from noncycling HeLa cells and this activity has lower fidelity when copying synthetic primer-templates than that obtained from log phase cultures. After exposure to the kinase, the fidelities and activities of the polymerase from both sources increase by 2- to 3-fold. This improved accuracy is not accompanied by the appearance of triphosphatase or DNase activities. Exposure to the protein kinase reduces the Km for activated DNA and for poly(dA-dT) but not for dNTPs. Moreover, the Vmax for activated DNA but not for poly(dA-dT) is increased approximately 2- to 3-fold. These alterations suggest a role for protein phosphorylation in modulating DNA polymerase alpha.
A specific peptide inhibitor of the class B metallo-β-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display (2005)

This is the first report of a peptide inhibitor for Class B metallo-beta-lactamases. It will be used as a lead to identify more potent small molecule inhibitors via peptidomimetics.
Guanidinylated Neomycin Delivers Large, Bioactive Cargo into Cells through a Heparan Sulfate-dependent Pathway (2007)

Facilitating the uptake of molecules into living cells is of substantial interest for basic research and drug delivery applications. Arginine-rich peptides have been shown to facilitate uptake of high molecular mass cargos into cells, but the mechanism of uptake is complex and may involve multiple receptors. In this report, we show that a derivative of the aminoglycoside antibiotic neomycin, in which all of the ammonium groups have been converted into guanidinium groups, can carry large (>300 kDa) bioactive molecules across cell membranes. Delivery occurs at nanomolar transporter concentrations and under these conditions depends entirely on cell surface heparan sulfate proteoglycans. Conjugation of guanidinoneomycin to the plant toxin saporin, a ribosome-inactivating agent, results in proteoglycan-dependent cell toxicity. In contrast, an arginine-rich peptide shows both heparan sulfate-dependent and -independent cellular uptake. The high selectivity of guanidinoneomycin for heparan sulfate suggests the possibility of exploiting differences in proteoglycan compositions to target delivery to different cell types.
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells (2009)

This study shows that of the PUFA studied, AA alone influences the expression of MMP-9, which might have implications in MMP-9 induced plaque rupture.
Reactive oxygen species inhibited by titanium oxide coatings (2003)

Titanium is a successful biomaterial that possesses good biocompatibility. It is covered by a surface layer of titanium dioxide, and this oxide may play a critical role in inhibiting reactive oxygen species, such as peroxynitrite, produced during the inflammatory response. In the present study, titanium dioxide was coated onto silicone substrates by radio-frequency sputtering. Silicone coating with titanium dioxide enhanced the breakdown of peroxynitrite by 79%. At physiologic pH, the peroxynitrite donor 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) was used to nitrate 4-hydroxyphenylacetic acid (4-HPA) to form 4-hydroxy-3-nitrophenyl acetic acid (NHPA). Titanium dioxide-coated silicone inhibited the nitration of 4-HPA by 61% compared to aluminum oxide-coated silicone and 55% compared to uncoated silicone. J774A.1 mouse macrophages were plated on oxide-coated silicone and polystyrene and stimulated to produce superoxide and interleukin-6. Superoxide production was measured by the chemiluminescent reaction with 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (MCLA). Titanium dioxide-coated silicone exhibited a 55% decrease in superoxide compared to uncoated silicone and a 165% decrease in superoxide compared to uncoated polystyrene. Titanium dioxide-coated silicone inhibited IL-6 production by 77% compared to uncoated silicone. These results show that the anti-inflammatory properties of titanium dioxide can be transferred to the surfaces of silicone substrates.
Heart Rate Variability Is a Useful Parameter for Evaluation of Anticholinergic Effect Associated with Inducibility of Atrial Fibrillation (2005)

The beneficial effect of disopyramide for vagotonic AF is based on the decrease of basal vagal tone and attenuation of the effect of vagal stimulation in the atrial myocardium. HRV is a useful parameter for evaluation of the effect of antiarrhythmic drugs on the autonomic nerve system, and the evaluation of variability may be useful for testing drug efficacy for arrhythmias.
Online Learning of Probabilistic Appearance Manifolds for Video-Based Recognition and Tracking (2005)

This paper presents an online learning algorithm to construct from video sequences an image-based representation that is useful for recognition and tracking. For a class of objects (e.g., human faces), a generic representation of the appearances of the class is learned off-line. From video of an instance of this class (e.g., a particular person), an appearance model is incrementally learned on-line using the prior generic model and successive frames from the video. More specifically, both the generic and individual appearances are represented as an appearance manifold that is approximated by a collection of sub-manifolds (named pose manifolds) and the connectivity between them. In turn, each sub-manifold is approximated by a low-dimensional linear sub-space while the connectivity is modeled by transition probabilities between pairs of sub-manifolds. We demonstrate that our online learning algorithm constructs an effective representation for face tracking, and its use in video-based face recognition compares favorably to the representation constructed with a batch technique.
Insulin Resistance and the Prevention of Diabetes Mellitus (1994)

In 1992 the direct costs of diabetes mellitus and its complications in the United States were estimated at a staggering $45 billion,1 more than the total annual cost of the British National Health Service. Preventing this disease and especially its complications would greatly lighten both the human and the economic burdens it imposes. The landmark Diabetes Control and Complications Trial showed convincingly the protective value of blood glucose control in patients with insulin-dependent diabetes,2 and it is likely that the results are applicable to the equally vulnerable and much more numerous group of patients with non-insulin-dependent diabetes mellitus (NIDDM). If . . .
Telechelic diols from poly[(R)‐3‐hydroxybutyric acid] and poly{[(R)‐3‐hydroxybutyric acid]‐co‐[(R)‐3‐hydroxyvaleric acid]} (1996)

Abstract We describe the preparation of telechelic OH‐terminated poly[( R )‐3‐hydroxybutyric acid] (PHB) and poly{[( R )‐3‐hydroxybutyric acid]‐ co ‐[( R )‐3‐hydroxyvaleric acid]} (PHB/HV), on a semi‐preparative scale, by a transesterification procedure from the high‐molecular weight polymers. The oligomers have well‐defined reactive end groups and are well suited for the preparation of high‐molecular‐weight block copolymers by chain extension.
A C/X/Ku-band dual polarized Cassegrain antenna system (2003)

There is an increasing demand for multiple frequency band capability in satellite Earth station antenna systems. This paper describes an 18.3 m shaped Cassegrain antenna with a single aperture, tri-band, six-port receive-only, feed system. The frequencies of operation are 3.4-4.2 GHz, 7.25-7.75 GHz, and 10.9-12.75 GHz. The C- and X-band feed ports offer dual circular polarization, and the Ku-band ports offer dual linear polarization with an internal polarization vector angle adjustment mechanism. Frequency and polarization multiplexing is performed by a novel OMJ structure.