gebhart/patrepeval huggingface dataset:
In vitro activity of LY146032 against staphylococci, streptococci, and enterococci (1986)

The in vitro activities of LY146032 and seven comparative antimicrobial agents against 14 species of staphylococci, streptococci, and enterococci were studied. MICs of LY146032 were less than or equal to 0.5 microgram/ml for all staphylococci, including oxacillin-resistant strains; less than or equal to 0.25 microgram/ml for all streptococci (except viridans group streptococci); and less than or equal to 4 micrograms/ml for all viridans group streptococci and enterococci. MICs were minimally affected by variations in inoculum size, and LY146032 was bactericidal against all species tested.
Pulse Duration Dependent Asymmetry in Molecular Transmembrane Transport Due to Electroporation in H9c2 Rat Cardiac Myoblast Cells In Vitro (2021)

Electroporation (EP) is one of the successful physical methods for intracellular drug delivery, which temporarily permeabilizes plasma membrane by exposing cells to electric pulses. Orientation of cells in electric field is important for electroporation and, consequently, for transport of molecules through permeabilized plasma membrane. Uptake of molecules after electroporation are the greatest at poles of cells facing electrodes and is often asymmetrical. However, asymmetry reported was inconsistent and inconclusive-in different reports it was either preferentially anodal or cathodal. We investigated the asymmetry of polar uptake of calcium ions after electroporation with electric pulses of different durations, as the orientation of elongated cells affects electroporation to a different extent when using electric pulses of different durations in the range of 100 ns to 100 µs. The results show that with 1, 10, and 100 µs pulses, the uptake of calcium ions is greater at the pole closer to the cathode than at the pole closer to the anode. With shorter 100 ns pulses, the asymmetry is not observed. A different extent of electroporation at different parts of elongated cells, such as muscle or cardiac cells, may have an impact on electroporation-based treatments such as drug delivery, pulse-field ablation, and gene electrotransfection.
An extended overview of the Mothra software testing environment (2003)

The authors give a brief introduction to mutation analysis. They they discuss Mothra, emphasizing how it interacts with the tester. The authors present some major problems with using mutation analysis and discuss possible solutions. They conclude with a solution to one of these problems-a method of automatically generating mutation-adequate data.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study. (2003)

Several novel and previously undetected tumor promoting/inhibiting genes may be of importance in the molecular pathogenesis and malignant progression of PTC. Transcription of these genes may result in overexpression of proteins, such as c-MET, MMP-11, TIMP-1, and FN, which may contribute to the pathogenesis of PTC.
Locus heterogeneity of autosomal dominant long QT syndrome. (1993)

Autosomal dominant long QT syndrome (LQT) is an inherited disorder that causes syncope and sudden death from cardiac arrhythmias. In genetic linkage studies of seven unrelated families we mapped a gene for LQT to the short arm of chromosome 11 (11p15.5), near the Harvey ras-1 gene (H ras-1). To determine if the same locus was responsible for LQT in additional families, we performed linkage studies with DNA markers from this region (H ras-1 and MUC2). Pairwise linkage analyses resulted in logarithm of odds scores of -2.64 and -5.54 for kindreds 1977 and 1756, respectively. To exclude the possibility that rare recombination events might account for these results, we performed multipoint linkage analyses using additional markers from chromosome 11p15.5 (tyrosine hydroxylase and D11S860). Multipoint analyses excluded approximately 25.5 centiMorgans of chromosome 11p15.5 in K1756 and approximately 13 centiMorgans in K1977. These data demonstrate that the LQT gene in these kindreds is not linked to H ras-1 and suggest that mutations in at least two genes can cause LQT. While the identification of locus heterogeneity of LQT will complicate genetic diagnosis, characterization of additional LQT loci will enhance our understanding of this disorder.
IL7‐hCD25 and IL7‐Cre BAC transgenic mouse lines: New tools for analysis of IL‐7 expressing cells (2009)

IL-7 is a cytokine that is required for T-cell development and homeostasis as well as for lymph node organogenesis. Despite the importance of IL-7 in the immune system and its potential therapeutic relevance, questions remain regarding the sites of IL-7 synthesis, specific cell types involved and molecular mechanisms regulating IL-7 expression. To address these issues, we generated two bacterial artificial chromosome (BAC) transgenic mouse lines in which IL-7 regulatory elements drive expression of either Cre recombinase or a human CD25 (hCD25) cell surface reporter molecule. Expression of the IL-7.hCD25 BAC transgene, detected by reactivity with anti-hCD25 antibody, mimicked endogenous IL-7 expression. Fetal and adult tissues from crosses between IL-7.Cre transgenic mice and Rosa26R or R26-EYFP reporters demonstrated X-gal or YFP staining in tissues known to express endogenous IL-7 at some stage during development. These transgenic lines provide novel genetic tools to identify IL-7 producing cells in various tissues and to manipulate gene expression selectively in IL-7 expressing cells.
From Rubbish to a Large Scale Industry: A Simple Fabrication of Superfiber with Multitasking Applications (2015)

In the whole earth, people increased dramatically from generation to generation which had created a large scale of broken environment so that people are facing more various types of garbage. Most of garbages are not useful and as a matter of fact, they are used to be neglected. Furthermore, many efforts have been conducted to change it by many types of recycled methods. Here, a simple technique is proposed with and without using fires to transform the useless natural or man-made rubbish things to be a superfiber as well as thin film with multitasking applications in human daily life. Since most of earth environment is covered by oceans, here the authors show how the ocean related garbage such as the crab skins, broken coral reefs and beach stones were changed to be superfiber and a multitasking device prototype.
Cadmium Selenide Quantum Wires and the Transition from 3D to 2D Confinement (2003)

Soluble CdSe quantum wires are prepared by the solution-liquid-solid mechanism, using monodisperse bismith nanoparticles to catalyze wire growth. The quantum wires have micrometer lengths, diameters in the range of 5-20 nm, and diameter distributions of +/-10-20%. Spectroscopically determined wire band gaps compare closely to those calculated by the semiemipirical pseudopotential method, confirming 2D quantum confinement. The diameter dependence of the quantum wire band gaps is compared to that of CdSe quantum dots and rods. Quantum rod band gaps are shown to be delimited by the band gaps of dots and wires of like diameter, for short and long rods, respectively. The experimental data suggest that a length of ca. 30 nm is required for the third dimension of quantum confinement to fully vanish in CdSe rods. That length is about six times the bulk CdSe exciton Bohr radius.
Combination Chemoprevention for Colon Cancer Targeting Polyamine Synthesis and Inflammation (2009)

Increased polyamine synthesis and inflammation have long been associated with colon carcinogenesis in both preclinical models and in humans. Recent experimental studies suggest that polyamines may be mechanistically involved in colonic inflammatory processes. Genetic epidemiology results indicate that a single nucleotide polymorphism influencing the expression of a polyamine biosynthetic gene is associated with both risk of colon polyp occurrence and recurrence, and the response to aspirin as a polyp preventive agent. A prospective, randomized, placebo-controlled clinical trial of combination difluoromethylornithine, a selective inhibitor of polyamine synthesis, and sulindac, a nonsteroidal anti-inflammatory drug, found that the 3-year treatment was associated with a 70% reduction of recurrence of all adenomas, and over a 90% reduction of recurrence of advanced and/or multiple adenomas, without evidence of serious toxicities. This proof-of-principle trial indicates that targeting polyamine synthesis and inflammation can be an effective strategy for preventing the occurrence of the advanced and/or multiple adenomas that are most closely associated with the development of colon cancers in humans.
Heterogeneous Silicon/III–V Semiconductor Optical Amplifiers (2016)

We report high output power and high-gain semiconductor optical amplifiers integrated on a heterogeneous silicon/III-V photonics platform. The devices produce 25 dB of unsaturated gain for the highest gain design, and 14 dBm of saturated output power for the highest output power design. The amplifier structure is also suitable for lasers, and can be readily integrated with a multitude of silicon photonic circuit components. These devices are useful for a wide range of photonic integrated circuits. We show a design method for optimizing the amplifier for the desired characteristics. The amplifier incorporates a low loss and low reflection transition between the heterogeneous active region and a silicon waveguide, and we report transition loss below 1 dB across the entire measurement range and parasitic reflection coefficient from the transition below 1 · 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> .
Isoferritin composition of tissues and serum in human cancers. (1976)

A highly sensitive technique for isoferritin detection using 125I-labeled monospecific anti-human liver ferritin antibody for the identification of isoferritins after the analysis of small quantities of ferritin by isoelectric focusing in polyacryl-amide gels was applied to the study of renal, pancreatic, and colonic carcinomas. In all tumors studied, the isoferritin composition differed from that of the corresponding normal tissue; major isoferritins with pl more basic than those of the normal tissues were consistently detected. Composition of purified ferritin from metastases closely resembled the isoferritin composition of the primary tumors. Examination of the serum isoferritin profiles of four patients with cancers did not reveal the presence of any tumor-specific changes in isoferritins. It is suggested that the abnormality in tissue ferritins in the three human cancers studied is the synthesis of major isoferritins in the more basic range, rather than the appearance of tumor-specific isoferritins in the more acidic range.
Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient. (1995)

A radiation-sensitive fibroblast culture (180BR) established from an acute lymphoblastic leukemia patient who died following radiotherapy is defective in the repair of radiation-induced DNA double-strand breaks. The cells also show a reduced capacity to repair interphase chromosome damage visualized by means of premature chromosome condensation and metaphase chromosome aberrations measured by fluorescence in situ hybridization on chromosome 4. This case represents the first example in humans where hypersensitivity to ionizing radiation can be ascribed directly to a defect in DNA and chromosome repair, and the defect may underlie the cancerous phenotype observed.
Is Physician Detection Associated With Thinner Melanomas? (1999)

Thinner melanomas are more likely to have been detected by physicians. Increased awareness by all physicians may result in greater detection of early melanomas.
The actin binding site on thymosin β 4 promotes angiogenesis (2003)

Thymosin beta4 is a ubiquitous 43 amino acid, 5 kDa polypeptide that is an important mediator of cell proliferation, migration, and differentiation. It is the most abundant member of the beta-thymosin family in mammalian tissue and is regarded as the main G-actin sequestering peptide. Thymosin beta4 is angiogenic and can promote endothelial cell migration and adhesion, tubule formation, aortic ring sprouting, and angiogenesis. It also accelerates wound healing and reduces inflammation when applied in dermal wound-healing assays. Using naturally occurring thymosin beta4, proteolytic fragments, and synthetic peptides, we find that a seven amino acid actin binding motif of thymosin beta4 is essential for its angiogenic activity. Migration assays with human umbilical vein endothelial cells and vessel sprouting assays using chick aortic arches show that thymosin beta4 and the actin-binding motif of the peptide display near-identical activity at ~50 nM, whereas peptides lacking any portion of the actin motif were inactive. Furthermore, adhesion to thymosin beta4 was blocked by this seven amino acid peptide demonstrating it as the major thymosin beta4 cell binding site on the molecule. The adhesion and sprouting activity of thymosin beta4 was inhibited with the addition of 5-50 nM soluble actin. These results demonstrate that the actin binding motif of thymosin beta4 is an essential site for its angiogenic activity.
Self-service cloud computing (2012)

Modern cloud computing infrastructures use virtual machine monitors (VMMs) that often include a large and complex administrative domain with privileges to inspect client VM state. Attacks against or misuse of the administrative domain can compromise client security and privacy. Moreover, these VMMs provide clients inflexible control over their own VMs, as a result of which clients have to rely on the cloud provider to deploy useful services, such as VM introspection-based security tools.
Novel scheme for making cheap electricity with nuclear energy (1979)

Nuclear fuels should produce cheaper electricity than coal, considering their high specific energy and low cost. To exploit these properties, the scheme proposed here replaces the expensive reactor/steam-turbine system with an engine in which the expansion of a gas heated by a nuclear explosion raises a mass of liquid, thereby producing stored hydraulic energy. This energy could be converted to electricity by hydroelectric generation with water as the working fluid or by magnetohydrodynamic (MHD) generation with molten metal. A rough cost analysis suggests the hydroelectric system could reduce the present cost of electricity by two-thirds, and the MHD system by even more. Such cheap power would make feasible large-scale electrolysis to produce hydrogen and other fuels and chemical raw materials.
Practical Attack Graph Generation for Network Defense (2006)

Attack graphs are a valuable tool to network defenders, illustrating paths an attacker can use to gain access to a targeted network. Defenders can then focus their efforts on patching the vulnerabilities and configuration errors that allow the attackers the greatest amount of access. We have created a new type of attack graph, the multiple-prerequisite graph, that scales nearly linearly as the size of a typical network increases. We have built a prototype system using this graph type. The prototype uses readily available source data to automatically compute network reachability, classify vulnerabilities, build the graph, and recommend actions to improve network security. We have tested the prototype on an operational network with over 250 hosts, where it helped to discover a previously unknown configuration error. It has processed complex simulated networks with over 50,000 hosts in under four minutes
Dendritic cells require maturation via CD40 to generate protective antitumor immunity. (1998)

A critical role for CD40/CD154 interactions in the generation of protective cell-mediated tumor immunity has been demonstrated previously. Herein, we show that the failure to generate systemic tumor immunity in the absence of CD40/CD154 interactions correlates with an inhibition of Th1-type cytokine production following tumor vaccination. Furthermore, protective antitumor responses can be restored in CD40-deficient mice by the coadministration of CD40+/+ but not CD40-/- dendritic cells (DCs) with tumor Ag, suggesting that CD40 is critical for the maturation and function of DCs in vivo. Finally, we demonstrate that an IL-12-transduced but not a mock-transduced tumor vaccine induces systemic tumor immunity in anti-CD154-treated and CD154-deficient mice. These data suggest that impaired antitumor responses in the absence of CD40/CD154 interactions are the result of a lesion in APC function, namely IL-12 production, and that CD40 plays a critical role in the maturation of DCs in vivo.
Generalized version control in an object-oriented database (2003)

An important function of an engineering database management system is to support incremental and cooperative design in an orderly way. This calls for a version-control mechanism of some generality if it is to be appropriate to the design of complex objects. The authors consider the nature of design objects, and develop some functional requirements for version control of such objects. They outline the basic object-oriented database model, which they take as the foundation for their proposal. They then discuss the relationship between versions and the objects they exemplify, describe the mechanisms for the creation of versioned objects and the conversion of non-versioned objects to versioned form, study the impact on referencing and type checking in the object model, and arrive at a flexible notion of a context containing rules for version selection. Their implementation of some of these concepts is also described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Floating shield current suppression trap (2004)

Abstract Shield currents or common mode currents affect coil tuning, coil‐to‐coil coupling in phased array coils, image inhomogeneity, and most importantly can cause serious patient burns. Traditionally in MRI, shield currents are reduced by cable traps; they consist of a wound coaxial cable inductor tuned to the desired resonance frequency by a capacitor between end turns of the coaxial cable ground shield. This method increases losses and effects the overall phase distance between the coil and the preamplifiers. We present a cable trap that does not connect or solder to the cable and is completely splitable, allowing easy fitting over any cable without affecting any coil parameters (tuning or phase length). Multiple cables can be placed inside the shield current trap to simultaneously attenuate the shield currents from up to eight cables, as currently designed. The shield current trap reduces shield currents at 64 MHz by ∼30 dB. © 2004 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 21B: 26–31, 2004.
New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties (2012)

There is a growing interest in the development of new medical diagnostic tools with higher sensibility and less damage for the patient body, namely on imaging reporters for the management of diseases and optimization of treatment strategies. This article examines the properties of a new class of lanthanide complexes with a tripodal tris-3-hydroxy-4-pyridinone (tris-3,4-HOPO) ligand - NTP(PrHP)(3). Among the studies herein performed, major relevance is given to the thermodynamic stability of the complexes with a series of Ln(3+) ions (Ln = La, Pr, Gd, Er, Lu) and to the magnetic relaxation properties of the Gd(3+) complex. This hexadentate ligand enables the formation of (1 : 1) Ln(3+) complexes with high thermodynamic stability following the usual trend, while the Gd-chelates show improved relaxivity (higher hydration number), as compared with the commercially available Gd-based contrast agents (CAs); transmetallation of the Gd(3+)-L complex with Zn(2+) proved to be thermodynamically and kinetically disfavored. Therefore, NTP(PrHP)(3) emerges as part of a recently proposed new generation of CAs with prospective imaging sensibility gains.
Nucleotide sequence and genome organization of foot-and-mouth disease virus (1984)

A continuous 7802 nucleotide sequence spanning the 94% of foot and mouth disease virus RNA between the 5'-proximal poly(C) tract and the 3'-terminal poly(A) was obtained from cloned cDNA, and the total size of the RNA genome was corrected to 8450 nucleotides. A long open reading frame was identified within this sequence starting about 1300 bases from the 5' end of the RNA genome and extending to a termination codon 92 bases from its polyadenylated 3' end. The protein sequence of 2332 amino acids deduced from this coding sequence was correlated with the 260 K FMDV polyprotein. Its processing sites and twelve mature viral proteins were inferred from protein data, available for some proteins, a predicted cleavage specificity of an FMDV encoded protease for Glu/Gly(Thr, Ser) linkages, and homologies to related proteins from poliovirus. In addition, a short unlinked reading frame of 92 codons has been identified by sequence homology to the polyprotein initiation signal and by in vitro translation studies.
Loudness of dynamic stimuli in acoustic and electric hearinga) (1997)

Traditional loudness models have been based on the average energy and the critical band analysis of steady-state sounds. However, most environmental sounds, including speech, are dynamic stimuli, in which the average level [e.g., the root-mean-square (rms) level] does not account for the large temporal fluctuations. The question addressed here was whether two stimuli of the same rms level but different peak levels would produce an equal loudness sensation. A modern adaptive procedure was used to replicate two classic experiments demonstrating that the sensation of "beats" in a two- or three-tone complex resulted in a louder sensation [E. Zwicker and H. Fastl, Psychoacoustics-Facts and Models (Springer-Verlag, Berlin, 1990)]. Two additional experiments were conducted to study exclusively the effects of the temporal envelope on the loudness sensation of dynamic stimuli. Loudness balance was performed by normal-hearing listeners between a white noise and a sinusoidally amplitude-modulated noise in one experiment, and by cochlear implant listeners between two harmonic stimuli of the same magnitude spectra, but different phase spectra, in the other experiment. The results from both experiments showed that, for two stimuli of the same rms level, the stimulus with greater temporal fluctuations sometimes produced a significantly louder sensation, depending on the temporal frequency and overall stimulus level. In normal-hearing listeners, the louder sensation was produced for the amplitude-modulated stimuli with modulation frequencies lower than 400 Hz, and gradually disappeared above 400 Hz, resulting in a low-pass filtering characteristic which bore some similarity to the temporal modulation transfer function. The extent to which loudness was greater was a nonmonotonic function of level in acoustic hearing and a monotonically increasingly function in electric hearing. These results suggest that the loudness sensation of a dynamic stimulus is not limited to a 100-ms temporal integration process, and may be determined jointly by a compression process in the cochlea and an expansion process in the brain. A level-dependent compression scheme that may better restore normal loudness of dynamic stimuli in hearing aids and cochlear implants is proposed.