gebhart/patrepeval huggingface dataset:
Sensitivity of point- and line-source laser-generated acoustic wave to surface flaws (2003)

Laser generation and air-coupled detection were combined as a hybrid ultrasonic technique for the inspection of surface flaws in rail. Narrowband acoustic signals were generated using a formed laser source by focusing the laser light to a point and to a line on the surface of the rail. The pulse energy, and therefore the intensity of the laser source, varied such that the generated signal transitioned from the weak thermoelastic to the strong ablative regime. The detection of flaws using laser-generated surface acoustic wave, to the presence of surface flaws, was compared between both point and line laser sources operating under different pulse energy levels. The line source was found to be more sensitive to the presence of surface flaws than a point source. The sensitivity of the laser-generated acoustic signal appeared to be independent of the severity of the flaw and, within the ablative regime, independent of the laser-pulse energy. Theoretical analysis is provided to explain the underlying cause that influences the interaction of a formed laser-generated surface acoustic wave to surface flaws and how this sensitivity may vary between the thermoelastic and ablative regimes.
Parallel object-space hidden surface removal (1990)

A parallel object-space hidden surface removal algorithm for polyhedral scenes is presented. The uniform grid technique is used to achieve parallelism for the hidden line removal. A conflict-detection and back-off strategy is then used to obtain parallelism for the visible region reconstruction from the visible segments. The algorithm has been implemented on a Sequent Balance 21000 shared-memory parallel computer. An average speedup of 10 has been obtained using 15 processors.
475. Phase I Clinical Trial of Autologous CD19-Targeted 19-28z CAR T Cells in Adult Patients With Relapsed or Refractory B-ALL (2015)

Adult patients with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) have a dismal prognosis with a median overall survival (OS) < 6 months. Salvage chemotherapy is ineffective and often induces only a transient remission. We previously reported high anti-tumor activity of autologous T cells genetically modified to express 19-28z chimeric antigen receptor (CAR) targeting CD19 antigen in adult patients with ALL (Davila M et al. Sci Transl Med 2014). Herein, we report updated results and long-term outcome from our phase I clinical trial of 19-28z CAR T cells in adult patients with R/R ALL (NCT01044069). Adult patients with R/R B-ALL were enrolled, and underwent leukapheresis. T cells were transduced with a gamma-retroviral vector encoding a CAR construct composed of anti-CD19 scFv linked to CD28 and CD3ζ signaling domains (19-28z). All patients received lymphodepleting chemotherapy followed 2 days later by 1-3 x106 CAR T cells/kg. Bone marrow (BM) biopsy was performed immediately prior to T cell infusion for disease status assessment. 28 patients (pts) have been treated to date. The median age was 55 years (range, 23-74). 9 pts (32%) had Ph+ B-ALL (T315I mutation in 3 pts), 8 pts (29%) had prior allogeneic stem cell transplant (allo-SCT), and 22 pts (78%) had either primary refractory disease or CR1 duration of <12 months. Of the 28 pts, 27 pts were evaluable for response. At the time of 19-28z CAR T cell infusion, 14 of 27 evaluable pts had morphologic disease (>5% blasts in BM) and 13 pts had minimal residual disease (MRD). 24 of 27 pts (89%) were in complete remission (CR) following the 19-28z CAR T cell infusion; 11 of these pts had morphologic disease at the time of T cell infusion, and 13 pts had MRD. 21 of 24 CR (88%) was MRD negative. A median time to CR was 22.5 days (range, 9-33). 10 pts successfully underwent allo-HSCT following the 19-28z CAR T cell therapy. The median follow-up is 6 months (range, 1-38 months) with 15 pts having at least 6 months of follow-up. Responses appear durable with 12 pts remaining disease-free, including 7 pts without subsequent allo-SCT. Median OS of all pts is 8.5 months. While none of the 13 pts with MRD at the time of T cell infusion developed significant cytokine release syndrome (CRS), 5 of 15 pts with morphologic disease developed severe CRS that required either vasopressors or mechanical ventilation for hypoxia, successfully managed with corticosteroid and/or IL-6R inhibitor. Treatment with 19-28z CAR T cells can induce a high CR rate of 89% in these heavily pretreated adult pts with R/R ALL regardless of the disease risk characteristics including Ph+ status, age, pre-T cell disease burden, prior allo-SCT, and CR1 duration. While CRS can develop following T cell infusion, the risk of CRS predictably correlates with the disease burden and can successfully be managed with corticosteroid and/or IL-6R inhibitor. These findings support the use of 19-28z CAR T cells in adult pts with R/R ALL and warrant a further investigation in a larger phase 2 trial.
p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. (1997)

Myocyte cell loss is a prominent and important pathogenic feature of cardiac ischemia. We have used cultured neonatal rat cardiac myocytes exposed to prolonged hypoxia as an experimental system to identify critical factors involved in cardiomyocyte death. Exposure of myocytes to hypoxia for 48 h resulted in intranucleosomal cleavage of genomic DNA characteristic of apoptosis and was accompanied by increased p53 transactivating activity and protein accumulation. Expression of p21/WAF-1/CIP-1, a well-characterized target of p53 transactivation, also increased in response to hypoxia. Hypoxia did not cause DNA laddering or cell loss in cardiac fibroblasts. To determine whether the increase in p53 expression in myocytes was sufficient to induce apoptosis, normoxic cultures were infected with a replication-defective adenovirus expressing wild-type human p53 (AdCMV.p53). Infected cells expressed high intracellular levels of p53 protein and exhibited the morphological changes and genomic DNA fragmentation characteristic of apoptosis. In contrast, no genomic DNA fragmentation was observed in myocytes infected with the control virus lacking an insert (AdCMV.null) or in cardiac fibroblasts infected with AdCMV.p53. These results suggest that the intracellular signaling pathways activated by p53 might play a critical role in the regulation of hypoxia-induced apoptosis of cardiomyocytes.
Establishment and characterization of an undifferentiated human T leukemia cell line which requires granulocyte-macrophage colony stimulatory factor for growth. (1987)

A human leukemia cell line (TALL-101) was established from the bone marrow of a patient with an undifferentiated acute T cell leukemia using the conditioned medium (CM) of the human T cell leukemia virus (HTLV) II-transformed human cell line J-LB1. Immunofluorescence analysis on the original leukemic cells indicated the presence of T cell markers (Leu-1, Tdt, and T11); however, the established TALL-101 cell line expressed only antigens commonly present on progenitor cells, thymocytes, and myelomonocytic cells, but not on mature T cells. A high percentage of TALL-101 cells displayed the Tac antigen which was down-regulated upon incubation in the presence of recombinant human (rH) interleukin 2 (IL 2). Interferon (IFN)-gamma induced the appearance of class II histocompatibility leukocyte antigens (HLA) and of a T cell marker (3A1), and enhanced the expression of transferrin receptors on these cells. Further evidence for a T cell lineage of the TALL-101 cell line was provided by both chromosomic and genotypic analysis showing a translocation in chromosome 14 typical of T cell leukemias, and a rearrangement of the T-beta receptor locus. The growth-promoting activity in the J-LB1-CM was identified as granulocyte-macrophage colony stimulatory factor (GM-CSF), a growth factor which stimulates proliferation of normal myelomonocytic cells and other progenitor cells, but not known to have an effect on T cells. Dose response curves of [3H]thymidine incorporation and growth indicated that TALL-101 cells were sensitive to very low concentrations of rHGM-CSF, 5 ng/ml inducing maximal proliferation in chemically defined medium. The TALL-101 cell line is strictly GM-CSF-dependent for growth: upon depletion of GM-CSF from the culture medium, the cells stop proliferating immediately and die within 1 to 2 wk. The overall data, showing that GM-CSF is able to support the growth of a highly undifferentiated T cell leukemia, strongly suggests that this factor might have similar growth promoting effects on other immature T cell leukemias, and possibly, on normal T cell progenitors.
Adaptive signal processing (2002)

We describe a novel modular learning strategy for detection of a target signal of interest in a nonstationary environment, which is motivated by the information preservation rule. The strategy makes no assumptions on the environment. It incorporates three functional blocks: time-frequency analysis, feature extractions, and pattern classification, the delineations of which are guided by the information preservation rule. The time-frequency analysis implemented using Wigner-Ville distribution, transforms incoming received signal into a time-frequency image and accounts for the time-varying nature of the received signal's spectral context. This image provides a common input to a pair of channels, one of which is adaptively matched to interference acting alone, and the other is adaptively matched to target signal plus interference. Each channel of the receiver consists of a principal components analyser (for feature extraction) followed by a multilayer perceptron (for feature classification), which are implemented using self-organized and supervised forms of learning in feedforward neural networks, respectively.
Skeletal Myoblast Transplantation in Ischemic Heart Failure (2006)

In this cohort of severe heart failure patients both clinical status and EF stably improve over time with a strikingly low incidence of hospitalizations for heart failure (0.13/patient-years) and the arrhythmic risk can be controlled by medical therapy and/or on-request ACD implantation.
Fault detection based on Petri net models with faulty behaviors (2002)

We consider Petri net models of discrete event systems with faulty behaviors which are triggered by the firing of failure transitions. We extend a necessary and sufficient condition for diagnosability shown by Sampath et al. (1994, 1995) to unbounded Petri nets. But it is algorithmically impossible to check the condition in general. We introduce methods for modification of coverability trees in order to detect failure transitions. By using such approximated sets, we propose two kinds of diagnosers called a difference marking /spl omega/-diagnoser and an /spl omega/-refined diagnoser. For observable places whose token numbers are replaced by /spl omega/ in the coverability trees, the former diagnoser calculates difference between token numbers before and after partially observed markings change, and detects failures. In the latter diagnoser, we refine the symbol /spl omega/, and modify the coverability tree in order to distinguish markings reachable by normal behaviors from those reachable by faulty behaviors.
유전 및 육종 ; 염색체 이상에 관한 세포 유전학적 연구 (4) - 염색체 전좌 - (1994)

The early suppression of lethal gene maximizes the effect of domestical improvements applying cytogenetical analysis on the chromosome of dairy cattle, which demonstrated the chromosomal aberration. Fourteen females and three males of dairy cattle tested for the experiment. The chromosomal analysis cultivated blood from the jugluar vein or coccygeal vein of experimental cattle. The results obtained in the experiments show following: The diploid(2n=60) of female cattle has the 29 pairs of acrocentric autosome or telocentric, and the two large submetacentric XX chromosome. As staining the G-handing. one of them shoved chromosomal aberration. We have found the 1/29 translocation relating to calving, rearing and production efficiency.
Polypill Eligibility for Patients with Heart Failure With Reduced Ejection Fraction in South India: A Secondary Analysis of a Prospective, Interrupted Time Series Study (2021)

RESEARCH LETTER - No abstract available.
Low Plasma Lycopene Concentration Is Associated With Increased Intima-Media Thickness of the Carotid Artery Wall (2000)

Although a number of epidemiological studies have evaluated the association between ss-carotene and the risk of cardiovascular diseases, there has been little research on the role of lycopene, an acyclic form of ss-carotene, with regard to the risk of cardiovascular disease. We investigated the relationship between plasma concentrations of lycopene and intima-media thickness of the common carotid artery wall (CCA-IMT) in 520 middle-aged men and women (aged 45 to 69 years) in eastern Finland. They were examined from 1994 to 1995 at the baseline of the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study, a randomized trial concerning the effect of vitamin E and C supplementation on atherosclerotic progression. The subjects were classified into 2 categories according to the median concentration of plasma lycopene (0.12 micromol/L in men and 0.15 micromol/L in women). Mean CCA-IMT of the right and left common carotid arteries was 1.18 mm in men and 0.95 mm in women with plasma lycopene levels lower than the median and 0.97 mm in men (P:<0.001 for difference) and 0.89 mm in women (P:=0.027 for difference) with higher levels of plasma lycopene. In ANCOVA adjusting for cardiovascular risk factors and intake of nutrients, in men, low levels of plasma lycopene were associated with a 17.8% increment in CCA-IMT (P:=0.003 for difference). In women, the difference did not remain significant after the adjustments. We conclude that low plasma lycopene concentrations are associated with early atherosclerosis, manifested as increased CCA-IMT, in middle-aged men living in eastern Finland.
Infant respiratory function testing (1996)

Partial table of contents: Symbols, Abbreviations, and Units in Infant Pulmonary Function Testing (P. Quanjer, et al.). Measurement Conditions (C. Gaultier, et al.). Equipment Requirements for Infant Respiratory Testing (P. Sly & G. Davis). Measurement of Flow and Volume (J. Bates, et al.). Measurements During Tidal Breathing (S. Stick). Respiratory Inductive Plethysmography (J. Adams). Esophageal Manometry (Al. Coates, et al.). Passive Respiratory Mechanics (M. Fletcher, et al.). Measurements of Chest Wall Function (J. Allen & Y. Sivan). Forced Oscillation Technique (K. Desager, et al.). Forced Expiratory Maneuvers (P. Le Souef, et al.). Noninvasive Determination of Blood Gases (C. Poets & R. Martin). Clinical Epidemiology and Future Directions (J. Hanrahan, et al.). Index.
Cholesteric reflective display: Drive scheme and contrast (1994)

We studied the electro-optical response of a bistable cholesteric texture (BCT) display to ac voltage pulses. The material can be driven into states where planar and focal conic textures coexist at zero field and gray scale memory is achieved. According to the properties of the BCT display we designed two drive schemes; one for binary operation and the other for gray scale operation. We made a 320×320 pixel reflective display with a resolution of 80 lines/in. on a passive matrix. Measurement in an integration chamber showed that the display has higher contrast and better viewing angle than a reflective super twisted nematic display.
Nonlinear optical endoscopy based on a double-clad photonic crystal fiber and a MEMS mirror (2006)

Two-photon fluorescence and second harmonic generation microscopy have enabled functional and morphological in vivo imaging. However, in vivo applications of those techniques to living animals are limited by bulk optics on a bench top. Fortunately, growing functionality of fiber-optic devices and miniaturization of scanning mirrors stimulate the race to develop nonlinear optical endoscopy. In this paper, we report on a prototype of a nonlinear optical endoscope based on a double-clad photonic crystal fiber to improve the detection efficiency and a MEMS mirror to steer the light at the fiber tip. The miniaturized fiber-optic nonlinear microscope is characterized by rat esophagus imaging. Line profiles from the rat tail tendon and esophagus prove the potential of the technology in in vivo applications.
Identification of a Hydrophobic Exosite on Tissue Type Plasminogen Activator That Modulates Specificity for Plasminogen (1997)

A wide variety of important biological processes, including both the formation and dissolution of blood clots, depend on specific cleavage of individual target proteins by serine proteases. For example, tissue type plasminogen activator (t-PA), a trypsin-like enzyme that catalyzes the rate-limiting step of the endogenous fibrinolytic cascade, has only one known substrate in vivo, a single peptide bond (Arg561-Val562) in the proenzyme plasminogen. We have previously suggested that the specificity of t-PA for plasminogen is mediated in part by direct protein-protein interactions between the protease domain of t-PA and plasminogen that are distinct from those occurring within t-PA's active site. We demonstrate in this study that residues 420-423 of t-PA, which form a fully solvent-exposed, hydrophobic region of a surface loop mapping near one edge of the active site of t-PA, form, or are essential for the integrity of, an important, secondary site of interaction between t-PA and plasminogen that significantly modulates the rate of plasminogen activation in the absence, but not the presence, of fibrin. Identification of this secondary site of interaction between t-PA and plasminogen provides new insight into molecular details of the evolution of stringent substrate specificity by t-PA and suggests a novel strategy to enhance the fibrin dependence of plasminogen activation by t-PA. While the activity of wild type t-PA is stimulated by fibrin by a factor of approximately 650, the activity of two variants characterized in this study, t-PA/R275E,P422G and t-PA/R275E,P422E, is stimulated by a factor of approximately 39,000 or 61,000, respectively. It is therefore possible that, compared with wild type t-PA, the two variants would display enhanced "clot selectivity" in vivo due to reduced activity in the circulation but full activity at a site of fibrin deposition.
PTTG1 expression is associated with hyperproliferative disease and poor prognosis in multiple myeloma (2015)

This study supports a role for increased PTTG1 expression in augmenting tumour development in a subset of MM patients.
Genetic Susceptibility to Keloid Disease and Hypertrophic Scarring: Transforming Growth Factor β1 Common Polymorphisms and Plasma Levels (2003)

Keloid disease and hypertrophic scars are dermal tumors that are often familial and typically occur in certain races. Their exact etiology is still unknown. Transforming growth factor beta1 (TGF-beta1) plays a central role in wound healing and fibrosis and has been implicated in the pathogenesis of keloid disease and hypertrophic scar. The aims of this study were to measure the plasma level of TGF-beta1 in patients compared with controls, and to investigate the association of five common single nucleotide polymorphisms in TGF-beta1 with the risk of keloid disease and hypertrophic scar formation. Platelet-poor plasma levels of TGF-beta1 in 60 patients (15 with hypertrophic scar and 45 with keloid disease) and 18 controls were measured using an enzyme-linked immunoabsorbent assay technique. A polymerase chain reaction-restriction fragment length polymorphism method was used for genotyping TGF-beta1 polymorphisms. DNA samples from 133 patients (101 with keloid disease and 32 with hypertrophic scar) and 200 controls were examined. All patients and controls were Caucasians of Northern European extraction. There was no statistically significant difference in TGF-beta1 plasma levels between patients with keloid disease and hypertrophic scar and controls. There was also no statistically significant difference in genotype or allele frequency distributions between patients and controls for codons 10, 25, and 263 and for -509 and -800 single nucleotide polymorphisms of the TGF-beta1 gene. These results suggest that TGF-beta1 plasma levels and common polymorphisms are not associated with a risk of keloid disease and hypertrophic scar formation. This lack of association may be significant in view of the importance attached to the role of TGF-beta1 in dermal scarring. To the authors' knowledge, this is the first report of a case-control association study in keloid disease and hypertrophic scars using any single nucleotide polymorphisms.
Human Recombinant B7-H3 Expressed in &lt;italic&gt;E. coli&lt;/italic&gt; Enhances T Lymphocyte Proliferation and IL-10 Secretion &lt;italic&gt;in Vitro&lt;/italic&gt; (2004)

To explore the biofunctions of human B7-H3 on activated T lymphocyte, the gene of human B7-H3 encoding the extracellular region (IgV-like and IgC-like domains) was obtained by RT-PCR from human lung cells and subcloned into the prokaryotic expression vector pGEX-5X-3 to express glutathione S-transferase (GST) fusion protein. A 49 kD fusion protein (named as GST/hB7-H3 hereafter) was induced by IPTG and purified by standard methods reported in prokaryotic system. In the presence of the first signal imitated by anti-CD3 monoclonal antibody, T lymphocyte proliferation was observed by incubating purified T cells with soluble GST/hB7-H3 fusion protein by MTT assay. The concentrations of IFN-gamma and IL-10 in the supernatants of T cells were determined by ELISA. The results showed that the GST/hB7-H3 protein produced in bacteria had modest biological activities to proliferate the T lymphocyte and enhance IFN-gamma as well as IL-10 secretion.