gebhart/patrepeval huggingface dataset:
Spin polarization and magnetic effects in radical reactions (1984)

Studies on the effects of chemically induced dynamic nuclear and electron polarizations (CIDNP and CIDEP), and magnetic effects in radical reactions, have given rise to a new rapidly-progressing field of chemical physics. It came into being about ten years ago and has been attracting the ever-growing attention of researchers in related areas. The present book is a fairly all-embracing review of the state of affairs in this field. The book presents the physical background (both theoretical and experimental) of CIDNP and CIDEP, of the effects of an external magnetic field and magnetic nuclear moment (magnetic isotope effects) on radical reactions in solutions. Great attention has been paid to the application of chemical spin polarization and magnetic effects to solving various problems of chemical kinetics, structural chemistry, molecular physics, magnetobiology, and radiospectroscopy. The book will be useful for physicists, chemists and biologists employing CIDNP, CIDEP and magnetic effects in their investigations, as well as for researchers in related fields of chemical physics. The book can be also recommended for postgraduates and senior undergraduate students.
EFFECT OF NITROGEN ON WELD METAL TOUGHNESS IN SELF-SHIELDED FLUX-CORED ARC WELDING (1988)

Self-shielded flux-cored welds were made with varying electrode extension to investigate the effects of atmospheric nitrogen on mechanical properties. It was concluded that formation of aluminium nitrides seriously degrades weld metal toughness at long electrode extensions.
Nanomedicine in Chemoradiation (2013)

Chemoradiotherapy, the concurrent administration of chemotherapy and radiotherapy, is a treatment paradigm in oncology. It is part of the standard of care and curative treatment of many cancers. Given its importance, one of the primary goals of cancer research has been to identify agents and/or strategies that can improve the therapeutic index of chemoradiation. Recent advances in nanomedicine have provided a unique and unprecedented opportunity for improving chemoradiotherapy. Nanoparticles possess properties that are ideally suited for delivering chemotherapy in the chemoradiation setting. The goal of this review is to examine the role of incorporating nanomedicine into chemoradiation and the potential impact of nanomedicine to chemoradiotherapy.
In Vitro Antimalarial Activity of Chalcones and Their Derivatives (1995)

A series of chalcones and their derivatives have been synthesized and identified as novel potential antimalarials using both molecular modeling and in vitro testing against the intact parasite. A large number of chalcones and their derivatives were prepared using one-step Claisen-Schmidt condensations of aldehydes with methyl ketones. These condensates were screened in vitro against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum and shown to be active at concentrations in the nanomolar range. The most active chalcone derivative, 1-(2,5-dichlorophenyl)-3-(4-quinolinyl)-2-propen-1-one (7), had an IC50 value of 200 nM against both a chloroquine-resistant strain (W2) and a chloroquine-sensitive strain (D6). The resistance indexes for all compounds were substantially lower than for chloroquine, suggesting that this series will be active against chloroquine-resistant malaria. Structure-activity relationships (SAR) of the chalcones in the context of a homology-based model structure of the malaria trophozoite cysteine protease, the most likely target enzyme, are presented.
Mechanism of the Electrophoretic Deposition of CdSe Nanocrystal Films:  Influence of the Nanocrystal Surface and Charge (2007)

Electrophoretic deposition (EPD) leads to equally thick films of distinct colloidal CdSe nanocrystals on the positive and negative electrodes due to the deposition of equal numbers of negatively and positively charged nanocrystals, even though their concentrations are not equal in solution. EPD stops when the lower concentration charged nanocrystals, here the negatively charged nanocrystals, are depleted. These and other mechanistic features of EPD are analyzed using electrophoretic mobility (ζ-potential) analysis, photoluminescence, inductively coupled plasma−atomic emission spectroscopy, thermogravimetric analysis, and related measurements, which also show that the surface charge of nanocrystals can be substantially altered by the presence of coordinating ligands. Several cycles of nanocrystal washing are needed so the nanocrystals are able to transfer charge and/or “stick” to the electrodes upon electrophoretic deposition.
Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila (2013)

We report a simple yet extremely efficient platform for systematic gene targeting by the RNA-guided endonuclease Cas9 in Drosophila. The system comprises two transgenic strains: one expressing Cas9 protein from the germline-specific nanos promoter and the other ubiquitously expressing a custom guide RNA (gRNA) that targets a unique site in the genome. The two strains are crossed to form an active Cas9-gRNA complex specifically in germ cells, which cleaves and mutates the target site. We demonstrate rapid generation of mutants in seven neuropeptide and two microRNA genes in which no mutants have been described. Founder animals stably expressing Cas9-gRNA transmitted germline mutations to an average of 60% of their progeny, a dramatic improvement in efficiency over the previous methods based on transient Cas9 expression. Simultaneous cleavage of two sites by co-expression of two gRNAs efficiently induced internal deletion with frequencies of 4.3-23%. Our method is readily scalable to high-throughput gene targeting, thereby accelerating comprehensive functional annotation of the Drosophila genome.
Immunization of pigs with the attenuated S- strain of Japanese encephalitis virus. (1975)

The attenuated S- strain of Japanese encephalitis virus was produced from a wild strain of this virus by serial cultivation in primary bovine kidney cell cultures at 30 degrees C. Pigs were inoculated with it and examined for ability to produce antibody and protect themselves from infection with a wild strain used for challenge. In pigs inoculated with a single dose of 10(6.5) approximately 10(7.5) TCID50 of the S- strain, the neutralizing antibody titer or hemagglutination-inhibiting antibody (HI) titer increased to 10 approximately 320. An antibody titer exceeding 10 was maintained for 2 approximately 9 weeks. In pigs inoculated twice with 10(6.5) approximately 10(7.0) TCID50 of the S- strain, HI titer increased to 80 approximately 640. In many of these pigs, HI titers of 80 approximately 160 persisted for more than 6 weeks. Pigs inoculated once or twice with 10(7.0) approximately 10(7.5) TCID50 of the S- strain were challenged by inoculation with 10(4.5) approximately 10(5.5) TCID50 of a wild strain and examined for the occurrence of viremia. As a result, an ability to protect from infection was demonstrated in pigs which showed an antibody titer surpassing 10 at the time of challenge. Pregnant sows inoculated with 10(7.0) TCID50 of the S- strain were challenged by inoculation with 10(7.0) TCID50 of a wild strain. Neither death nor infection occurred to any fetus harbored by them. From these results, it is concluded that the S- strain can be used as live virus vaccine for porcine practice.
The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases (1999)

The Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), has been found to be present in a limited subset of lymphoproliferative disorders. Among these are the primary effusion lymphomas, formerly designated body cavity-based lymphomas, a rare type of malignant lymphoma which possesses an unusual set of clinical and biologic features, suggesting that they represent a distinct disease entity. This virus is also present in a large proportion of cases of multicentric Castleman's disease, particularly those associated with HIV-infection. In addition, KSHV has been implicated in the pathogenesis of multiple myeloma, where it has been identified in bone marrow adherent cells but not in the neoplastic myeloma plasma cell population. However, the latter finding remains controversial. The discovery of KSHV in a subset of malignant lymphomas has allowed the development of lymphoma cell lines which now serve as biological reagents for propagating the virus, as a substrate for serologic assays, and as a model system for pathobiologic studies. This review discusses the features of KSHV-associated lymphoproliferative disorders and the evidence supporting its role in the pathogenesis of these diseases.
Synthesis of peptide alkaloids. 5. New method for synthesis of ansa peptides. Amino acids and peptides. 34 (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of peptide alkaloids. 5. New method for synthesis of ansa peptides. Amino acids and peptides. 34Ulrich Schmidt, Albrecht Lieberknecht, Helmut Griesser, and Joerg TalbierskyCite this: J. Org. Chem. 1982, 47, 17, 3261–3264Publication Date (Print):August 1, 1982Publication History Published online1 May 2002Published inissue 1 August 1982https://pubs.acs.org/doi/10.1021/jo00138a012https://doi.org/10.1021/jo00138a012research-articleACS PublicationsRequest reuse permissionsArticle Views498Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding FRET as a Research Tool for Cellular Studies (2015)

Communication of molecular species through dynamic association and/or dissociation at various cellular sites governs biological functions. Understanding these physiological processes require delineation of molecular events occurring at the level of individual complexes in a living cell. Among the few non-invasive approaches with nanometer resolution are methods based on Förster Resonance Energy Transfer (FRET). FRET is effective at a distance of 1-10 nm which is equivalent to the size of macromolecules, thus providing an unprecedented level of detail on molecular interactions. The emergence of fluorescent proteins and SNAP- and CLIP- tag proteins provided FRET with the capability to monitor changes in a molecular complex in real-time making it possible to establish the functional significance of the studied molecules in a native environment. Now, FRET is widely used in biological sciences, including the field of proteomics, signal transduction, diagnostics and drug development to address questions almost unimaginable with biochemical methods and conventional microscopies. However, the underlying physics of FRET often scares biologists. Therefore, in this review, our goal is to introduce FRET to non-physicists in a lucid manner. We will also discuss our contributions to various FRET methodologies based on microscopy and flow cytometry, while describing its application for determining the molecular heterogeneity of the plasma membrane in various cell types.
Outdoor MIMO wireless channels: models and performance prediction (2002)

We present a new model for multiple-input-multiple-output (MIMO) outdoor wireless fading channels and their capacity performance. The proposed model is more general and realistic than the usual independent and identically distributed (i.i.d.) model, and allows us to investigate the behavior of channel capacity as a function of the scattering radii at transmitter and receiver, distance between the transmit and receive arrays, and antenna beamwidths and spacing. We show how the MIMO capacity is governed by spatial fading correlation and the condition number of the channel matrix through specific sets of propagation parameters. The proposed model explains the existence of "pinhole" channels which exhibit low spatial fading correlation at both ends of the link but still have poor rank properties, and hence, low ergodic capacity. In fact, the model suggests the existence of a more general family of channels spanning continuously from full rank i.i.d. to low-rank pinhole cases. We suggest guidelines for predicting high rank (and hence, high ergodic capacity) in MIMO channels, and show that even at long ranges, high channel rank can easily be sustained under mild scattering conditions. Finally, we validate our results by simulations using ray tracing techniques. Connections with basic antenna theory are made.
Digital Registration of Multispectral Video Imagery (1969)

This paper describes an adaptive system for achieving spatial registration of digitized imagery. Multispectral imagery is obtained from sources such as multilens cameras, multichannel optical-mechanical line scanners, and multiple TV camera systems. The system converts the raster scan imagery to an array of binary numbers representing brightness at discrete points in the scene. An analysis method is described which estimates the difficulty of registering these multispectral digital pictures. This measure is used to control the registration algorithm to improve the rate of processing. Experiments are described which compare the performance of the system with and without adaptive control. Registration of test imagery in three categories is carried out and some results are presented.
Twists, Knots, and Rings in Proteins (2003)

In recent years an increasing number of miniproteins containing an amide-cyclized backbone have been discovered. The cyclotide family is the largest group of such proteins and is characterized by a circular protein backbone and six conserved cysteine residues linked by disulfide bonds in a tight core of the molecule. These form a cystine knot in which an embedded ring formed by two of the disulfide bonds and the connecting backbone segment is threaded by a third disulfide bond. In the current study we have undertaken high resolution structural analysis of two prototypic cyclotides, kalata B1 and cycloviolacin O1, to define the role of the conserved residues in the sequence. We provide the first comprehensive analysis of the topological features in this unique family of proteins, namely rings (a circular backbone), twists (a cis-peptide bond in the Möbius cyclotides) and knots (a knotted arrangement of the disulfide bonds).
65 GW of New Generating Capacity Scheduled Worldwide by 2005 (1998)

Projected electric capacity additions worldwide from 1996-2005are es timat ed to be around 665 gigawatts (GW), of which 58% is inAsi a , according to Utility Data Institute (UDD. Assuming an av erag einstall ed cost of $1,000 per kilowatt (kW), construction of this newcapacit y will require a worldwide investment on the order of $700billion . An additional 589 GW of power plants with service dates aft er2005 or still in th e planning stages have been identified.The fourth edition of the World Directory of New Electric PowerPlant s contain s information on 7,481 projected generating units at3,857 plant sites : these facilities are owned by 725 utilities , 657 in-du str ial autoproducers, 722 "pr iva t e power " companies , and 76unid entified organizations . Generating units in the data ba se havecomm ercial service dates out past 2015.The "new plant " data published in this directory reflect a cons er-vat ive, "bott oms -u p" research approach. Although new power pl ant swill lik ely be added beyond those currently "in the pipeline," som e ofth e facilities currently planned by utilities or autoproducers ma y bedef err ed or canceled. It should also be noted that many small genera-tor s-IC engines , wind turbines , minihydro, etc .-are being ord ered ,bu t th eir aggregate capacity is small in comparison to large centralst at ion hydro and thermal plants .
Novel roles for mammalian septins: from vesicle trafficking to oncogenesis (2001)

In recent years a convergence of various aspects of cell biology has become apparent, and yet investigators are only beginning to grasp the underlying unifying mechanisms. Among the proteins that participate in diverse aspects of cell biology are the septins. These are a group of novel GTPase proteins that are broadly distributed in many eukaryotes except plants. Although septins were originally identified as a protein family involved in cytokinesis in yeast, recent advances in the field have now ascribed additional functions to these proteins. In particular, the number of known mammalian septin family members has increased dramatically as more data has become available through genome analyses. We suggest a classification for the mammalian septins based on the sequence homologies in their highly divergent N- and C-termini. Recent work suggests novel functions for septins in vesicle trafficking, oncogenesis and compartmentalization of the plasma membrane. Given the ability of the septins to bind GTP and phosphatidylinositol 4,5-bisphosphate in a mutually exclusive manner, these proteins might be crucial elements for the spatial and/or temporal control of diverse cellular functions. As the functions of the septins become unraveled, our understanding of seemingly different cellular processes may move a step further.
The vacuum (2005)

We present the design and evaluation of the vacuum, a new interaction technique that enables quick access to items on areas of a large display that are difficult for a user to reach without significant physical movement. The vacuum is a circular widget with a user controllable arc of influence that is centered at the widget's point of invocation and spans out to the edges of the display. Far away objects residing inside this influence arc are brought closer to the widget's centre in the form of proxies that can be manipulated in lieu of the original. We conducted two experiments which compare the vacuum to direct picking and an existing technique called drag-and-pick [2]. Results show that the vacuum outperforms existing techniques when selecting multiple targets in a sequence, performs similarly to existing techniques when selecting single targets located moderately far away, and slightly worse with single targets located very far away in the presence of distracter targets along the path.
A monoclonal antibody to the desmosomal glycoprotein desmoglein I binds the same polypeptide as human autoantibodies in pemphigus foliaceus. (1986)

Recent studies have demonstrated that antibodies from about half of patients with pemphigus foliaceus (PF) bind to a 160 kd polypeptide ("PF antigen") in sodium dodecyl sulfate (SDS) extracts of normal human epidermis. Desmoglein (DG) I, a glycoprotein enriched in desmosomal cores, is approximately the same m.w. as PF antigen. To demonstrate that PF autoantibodies bind to DG I, we used a monoclonal IgG antibody (MmDGI-1) that was raised against bovine muzzle desmosomal cores, and that specifically binds DG I. Double immunofluorescence labeling was performed on the same section of normal human skin with PF antibodies, detected by fluorescein-conjugated goat anti-human IgG, and MmDGI-1, detected by rhodamine-conjugated goat anti-mouse IgG. The pattern of reactivity with both antibodies was identical. Immunoblotting studies on proteins extracted from normal human epidermis and separated by SDS-polyacrylamide gel electrophoresis demonstrated that PF antibodies and MmDGI-1 bound co-migrating polypeptide bands of approximate m.w. 160,000. To confirm that these were identical polypeptides, we performed immunoblots of these epidermal extracts that were separated by two-dimensional gel electrophoreses (isoelectric focusing followed by SDS-PAGE). PF antibodies and MmDGI-1 bound identical spots with pI approximately 5.4 to 5.7 and m.w. approximately 160,000. These studies demonstrate that autoantibodies from certain patients with PF, a disorder of cell adhesion, bind to DG I, a desmosomal core glycoprotein.
The New South Wales-Queensland Interconnection: Extending the Eastern States Electricity Network (1994)

Technical and economic feasibility studies undertaken by the Queensland Electricity Commission and Pacific Power over several years show that a viable interconnection could be formed that would be commercially attractive to the two states from late this decade. Interconnection between the New South Wales and Queensland systems would facilitate greater competition in the electricity market, allow the sharing of contingency reserves, and enable more efficient use of existing generating capacity. Work is currently proceeding on Environmental Impact Assessment preparation and mute selection, with the objective of securing easements from July 1996. A bidirectional transfer capacity of about 500 MW appears to be the most probable initial development, which can be achieved by a double circuit 330 kV transmission line, using either HVAC or HVDC technology. This paper discusses the technical and economic feasibility of the project, including selection of interconnection capacity and type, project timing, determination of capital and operating cost savings, and opportunities in the national market.
Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization by Conformationally Restricted Analogues of Lavendustin A (2003)

Compounds in the lavendustin A series have been shown to inhibit both protein-tyrosine kinases (PTKs) and tubulin polymerization. Since certain lavendustin A derivatives can exist in conformations that resemble both the trans-stilbene structure of the PTK inhibitor piceatannol and the cis-stilbene structure of the tubulin polymerization inhibitor combretastatin A-4, the possibility exists that the ratio of the two types of activities of the lavendustins could be influenced through the synthesis of conformationally restricted analogues. Accordingly, the benzylaniline structure of a series of pharmacologically active lavendustin A fragments was replaced by either their cis- or their trans-stilbene relatives, and effects on both inhibition of tubulin polymerization and cytotoxicity in cancer cell cultures were monitored. Both dihydrostilbene and 1,2-diphenylalkyne congeners were also prepared and evaluated biologically. Surprisingly, conformational restriction of the bridge between the two aromatic rings of the lavendustins had no significant effect on biological activity. On the other hand, conversion of the three phenolic hydroxyl groups of the lavendustin A derivatives to their corresponding methyl ethers consistently abolished their ability to inhibit tubulin polymerization and usually decreased cytotoxicity in cancer cell cultures as well, indicating the importance of at least one of the phenolic hydroxyl groups. Further investigation suggested that the phenolic hydroxyl group in the salicylamide ring was required for activity, while the two phenol moieties in the hydroquinone ring could be methylated with retention of activity. Two of the lavendustin A derivatives displayed IC(50) values of 1.4 microM for inhibition of tubulin polymerization, which ranks them among the most potent of the known tubulin polymerization inhibitors.