gebhart/patrepeval huggingface dataset:
Absorption detection in capillary electrophoresis by fluorescence energy transfer (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAbsorption detection in capillary electrophoresis by fluorescence energy transferTommy W. Garner and Edward S. YeungCite this: Anal. Chem. 1990, 62, 20, 2193–2198Publication Date (Print):October 15, 1990Publication History Published online1 May 2002Published inissue 15 October 1990https://pubs.acs.org/doi/10.1021/ac00219a008https://doi.org/10.1021/ac00219a008research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A new base-stable linker for solid-phase oligonucleotide synthesis (1989)

The succinyl-sarcosyl linker (1b), which is stable to prolonged contact with 1,8-diazabicyclo[5.4.0]undec-7-ene but cleaves rapidly with aqueous ammonia, is of potential value in solid-phase oligonucleotide synthesis.
Long-Term Survival of Hamster Hearts in Presensitized Rats (2000)

We transplanted hamster hearts into rats that had been sensitized to hamster cardiac grafts 5 days earlier as a model for discordant xenotransplantation. Sensitized rats had high serum levels of elicited anti-donor IgM and IgG that caused hyperacute rejection. Transient complement inhibition with cobra venom factor (CVF) plus daily and continuing cyclosporin A (CyA) prevented hyperacute rejection. However, grafts underwent delayed xenograft rejection (DXR). DXR involved IgG and associated Ab-dependent cell-mediated rejection, because depletion of IgG or Ab-dependent cell-mediated rejection-associated effector cells prolonged graft survival and the serum-mediated Ab-dependent cell-mediated cytotoxicity in vitro. Blood exchange in combination with CVF/CyA treatment dramatically decreased the level of preexisting Abs, but DXR still occurred in association with the return of Abs. Splenectomy and cyclophosphamide acted synergistically to delay Ab return, and when combined with blood exchange/CVF/CyA facilitated long-term survival of grafts. These grafts survived in the presence of anti-donor IgM, IgG, and complement that precipitated rejection of naive hearts, indicating that accommodation (survival in the presence of anti-graft Abs and complement) had occurred. We attribute the long-term survival to the removal of preexisting anti-donor Abs and therapy that attenuated the rate of Ab return. Under such conditions, the surviving hearts showed expression in endothelial cells and smooth muscle cells of protective genes and an intragraft Th2 immune response. Th2 responses and protective genes are associated with resistance to IgM- and IgG-mediated, complement-dependent and -independent forms of rejection.
Cloning and expression of the leukotoxin gene from Actinobacillus actinomycetemcomitans (1989)

The leukotoxin produced by Actinobacillus actinomycetemcomitans has been implicated in the etiology of juvenile periodontitis. To initiate a genetic analysis of the role of this protein in disease, we have cloned the leukotoxin gene in Escherichia coli. Recombinant colonies carrying toxin gene sequences were isolated by screening a genomic A. actinomycetemcomitans library with a DNA probe for the leukotoxin gene from a related bacterium, Pasteurella haemolytica. To demonstrate that the cloned A. actinomycetemcomitans DNA contained a functional leukotoxin gene, protein extracts of E. coli containing the A. actinomycetemcomitans clone were tested directly for leukotoxic activity against human cell lines in chromium release assays. A construct containing the entire cloned region produced a functional toxin. No cytotoxicity was seen when extracts from cells containing plasmids with deletions in the putative coding region were used. Furthermore, the toxin produced by the cloned gene has the same target cell specificity as the leukotoxin extracted directly from A. actinomycetemcomitans. These results indicate that sequences encoding a functional leukotoxin have been cloned and are expressed in E. coli. Southern blot analysis of DNA from leukotoxin-producing (Lkt+) and non-leukotoxin-producing (Lkt-) strains indicated that the Lkt- strain also contained a copy of the gene.
Deep Learning Made Easier by Linear Transformations in Perceptrons (2012)

We transform the outputs of each hidden neuron in a multi-layer perceptron network to be zero mean and zero slope, and use separate shortcut connections to model the linear dependencies instead. This transformation aims at separating the problems of learning the linear and nonlinear parts of the whole input-output mapping, which has many benefits. We study the theoretical properties of the transformation by noting that they make the Fisher information matrix closer to a diagonal matrix, and thus standard gradient closer to the natural gradient. We experimentally confirm the usefulness of the transformations by noting that they make basic stochastic gradient learning competitive with state-of-the-art learning algorithms in speed, and that they seem also to help find solutions that generalize better. The experiments include both classification of handwritten digits with a 3-layer network and learning a low-dimensional representation for images by using a 6-layer auto-encoder network. The transformations were beneficial in all cases, with and without regularization. 1
Advances in the treatment of lysosomal storage disease (2001)

If a group of metabolic paediatricians had been asked 10 years ago which disorders they thought would be the most treatable at the start of the new millennium, very few would have mentioned lysosomal storage disorders (LSDs). The early onset, progressive nature, and tendency to involve the CNS have always been regarded as major hurdles to effective treatment. However, the final decade of the 20th century has seen developments in organ transplantation, enzyme replacement therapy (ERT), and gene transfer so that curative treatment for at least some of these disorders is no longer a distant goal.
THE STRUCTURE AND FUNCTION OF YEAST CENTROMERES (1985)

Orthologs and paralogs are two fundamentally different types of homologous genes that evolved, respectively, by vertical descent from a single ancestral gene and by duplication. Orthology and paralogy are key concepts of evolutionary genomics. A ...Read More
Albuminuria and Risk of Cardiovascular Events, Death, and Heart Failure in Diabetic and Nondiabetic Individuals (2001)

Our results indicate that any degree of albuminuria is a risk factor for CV events in individuals with or without DM; the risk increases with the ACR, starting well below the microalbuminuria cutoff. Screening for albuminuria identifies people at high risk for CV events.
Cooperation between the Hemagglutinin of Avian Viruses and the Matrix Protein of Human Influenza A Viruses (2002)

To analyze the compatibility of avian influenza A virus hemagglutinins (HAs) and human influenza A virus matrix (M) proteins M1 and M2, we doubly infected Madin-Darby canine kidney cells with amantadine (1-aminoadamantane hydrochloride)-resistant human viruses and amantadine-sensitive avian strains. By using antisera against the human virus HAs and amantadine, we selected reassortants containing the human virus M gene and the avian virus HA gene. In our system, high virus yields and large, well-defined plaques indicated that the avian HAs and the human M gene products could cooperate effectively; low virus yields and small, turbid plaques indicated that cooperation was poor. The M gene products are among the primary components that determine the species specificities of influenza A viruses. Therefore, our system also indicated whether the avian HA genes effectively reassorted into the genome and replaced the HA gene of the prevailing human influenza A viruses. Most of the avian HAs that we tested efficiently cooperated with the M gene products of the early human A/PR/8/34 (H1N1) virus; however, the avian HAs did not effectively cooperate with the most recently isolated human virus that we tested, A/Nanchang/933/95 (H3N2). Cooperation between the avian HAs and the M proteins of the human A/Singapore/57 (H2N2) virus was moderate. These results suggest that the currently prevailing human influenza A viruses might have lost their ability to undergo antigenic shift and therefore are unable to form new pandemic viruses that contain an avian HA, a finding that is of great interest for pandemic planning.
Improved independent gate N-type FinFET fabrication and characterization (2003)

N-type independent gate FinFETs (IGFinFETs) have been fabricated and characterized. Previous published results for this structure highlighted processing deficiencies. Several process enhancements have improved device results beyond those previously reported. These process improvements are presented, and the resulting device is demonstrated. Device results for 2 micron channel length devices are shown. Six decades of drain current suppression and low gate leakage currents are achieved. Subthreshold slope of 200 mV/dec and a threshold voltage tuning range of 1.7 V are demonstrated. This device combines the behavioral characteristics of independent-double-gate MOSFETs with the processing advantages and integration of FinFETs.
Mothers' Prosodic Features: Strategies To Guide Young Children's Understanding of Book Language. (1999)

Mothers use prosody to engage children during book reading. Thus, prosody may contribute to children’s literacy. The purpose of this study was to describe how twenty-five mothers across children’s age groups (6-month olds, 12-month-olds, 18-month-olds, 24-month-olds, and 4-year-olds) used prosody, specifically pitch and stress variations, while reading with their children. Common speech samples from the readings of two different texts (narrative and expository) were analyzed. In addition, the mothers were questioned about their use of expressive language while reading. Patterns from the data showed that the mothers of the 6-month-olds did not vary their speech as often. They used the book reading event to teach basic book reading concepts and to play. The narrative text showed the use of more expressive language. The mothers’ intent was to guide children’s understanding of the complexities of the story. All the mothers used pitch and stress in conjunction with other book reading strategies to scaffold the texts for their children. Mothers' prosodie features: Strategies to guide young children's understanding of book language Linda E. Martin Ball State University
GCRDb: a G-protein-coupled receptor database. (1994)

G-protein-coupled receptors (GCRs) are a very large protein family and are critical components in many different autocrine, paracrine and endocrine signaling systems in animals. Current estimates are that humans have several thousand GCRs encoded by only slightly fewer genes. I have developed GCRDb, a database of sequences and other data relevant to the study of the biology of the receptors. The database implementation, data collection, and query system are described. An integral component of the design of GCRDb is the classification of GCRs in families. The current composition of GCRDb is presented in a table showing the number of entries in each family and group as derived from accepted mutation parsimony analyses.
Unitary space-time modulation for multiple-antenna communications in Rayleigh flat fading (2000)

Motivated by information-theoretic considerations, we propose a signaling scheme, unitary space-time modulation, for multiple-antenna communication links. This modulation is ideally suited for Rayleigh fast-fading environments, since it does not require the receiver to know or learn the propagation coefficients. Unitary space-time modulation uses constellations of T/spl times/M space-time signals (/spl Phi//sub i/, l=1, ..., L), where T represents the coherence interval during which the fading is approximately constant, and M<T is the number of transmitter antennas. The columns of each /spl Phi//sub i/ are orthonormal. When the receiver does not know the propagation coefficients, which between pairs of transmitter and receiver antennas are modeled as statistically independent, this modulation performs very well either when the signal-to-noise ratio (SNR) is high or when T/spl Gt/M. We design some multiple-antenna signal constellations and simulate their effectiveness as measured by bit-error probability with maximum-likelihood decoding. We demonstrate that two antennas have a 6-dB diversity gain over one antenna at 15-dB SNR.
Transient liquid crystal thermometry of microfabricated PCR vessel arrays (1998)

Polymerase chain reaction (PCR) using micromachined structures promises improved temperature uniformity and cycling time together with decreased reagent and sample volumes. Thermal design of these structures will benefit from measurements of the temperature distribution in the reacting liquid. We report measurements of temperature uniformity and time constant in a microfabricated 18-vessel array using encapsulated liquid crystals suspended in the liquid. Separate sets of crystals are used to image temporal and spatial temperature variations near the processing thresholds of 55/spl deg/C and 95/spl deg/C with a resolution of 0.1/spl deg/C. While the thermometry technique developed here is particularly useful for characterizing microfabricated PCR systems, it can also aid with the thermal design of a broad variety of microfluidic devices.
Nanoscale Cage-like Structures Derived from Polyisoprene-Containing Shell Cross-linked Nanoparticle Templates (2004)

Hollowed materials of nanoscopic dimensions offer exciting possibilities in a number of fields such as therapeutics and imaging. The production of nanoscopic cage-like materials is described, based upon the excavation of shell cross-linked nanoparticle (SCK) templates. This report focuses upon extensive characterization of the ozonolysis reaction conditions used to degrade the core material, which demonstrates that thirty minutes of ozone treatment is optimal. The resulting nanocage is also shown to undergo pH tunable hydrodynamic diameter variations and to demonstrate a loss of hydrophobic guest interactions, relative to the SCK precursors.
Online Monitoring of Aromatic Hydrocarbons Using a Near-Ultraviolet Fiber-Optic Absorption Sensor (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOnline Monitoring of Aromatic Hydrocarbons Using a Near-Ultraviolet Fiber-Optic Absorption SensorTye E. Barber, Walter G. Fisher, and Eric A. WachterCite this: Environ. Sci. Technol. 1995, 29, 6, 1576–1580Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/es00006a021https://doi.org/10.1021/es00006a021research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coherent Optical Techniques for the Analysis of Tissue Structure and Dynamics (1999)

This paper summarizes the description of the speckle-correlation, speckle-interferometric, and polarimetric methods and instruments designed for various tissue structure imaging and their optical and dynamical parameter monitoring. © 1999 Society of Photo-Optical Instrumentation Engineers.
Biomechanical Evaluation of Four Different Posterior Atlantoaxial Fixation Techniques (1992)

Four different techniques for posterior atlantoaxial fusion were tested in vitro: 1) wire fixation with one median graft (Gallie type); 2) wire fixation with two bilateral grafts (Brooks type); 3) transarticular screw fixation (Magerl); and, 4) two bilateral posterior clamps (Halifax). The experiment was designed to determine the immediate three-dimensional stability of the spinal construct. Ten fresh human cadaveric specimens were tested intact, injured, and instrumented with each of the fixation techniques. The injury consisted of a severe soft tissue injury model, in which the alar, transverse, and capsular ligaments were transected. The three-dimensional motions of C1 relative to C2 were measured as the specimens were subjected to loads of pure moments in flexion-extension, axial rotation, and lateral bending. Each fixation technique significantly decreased motion in all directions, as compared to the intact and injured spines. We found that the Gallie system generally allowed significantly more rotation in flexion, extension, axial rotation, and lateral bending than the other three fixation techniques. There was generally no significant difference between the amount of rotation with the other three fixation techniques. However, the Magerl technique tended to allow the least rotation. The anteroposterior translation of two points on C1 were about equal for all fixation techniques.
Degeneration and Regeneration of the Nervous System. (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Robust object recognition using a cascade of geometric consistency filters (2009)

Bag-of-words is a popular and successful approach to performing object recognition. Its performance is limited by not considering relative geometry information. This limitation is particularly stark when there is significant image noise. We propose a ¿bag-of-phrases¿ model which extends bag-of-words by enforcing geometric consistency through application of a ¿geometric grammar¿ in a filter cascade. Experimental results on a computer generated dataset show increased robustness to clutter and noise as demonstrated by more than two orders of magnitude reduction in false positives compared with bag-of-words.
Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer (2001)

RAC 3, one of the p160 family of co-activators is known to enhance the transcriptional activity of a number of steroid receptors. As co-activators are also known to enhance androgen receptor (AR) activity, we investigated the role of RAC 3 in the context of prostate cancer. In prostate cancer cell lines, we found variable levels of the RAC 3 protein with highest expression seen in AR-positive LNCaP cells, moderate expression in AR-negative PC 3 cells and low-level expression in AR-negative DU 145 cells. Immuno-precipitation studies showed that endogenous RAC 3 interacted with the AR in vivo and transfection assays confirmed that RAC 3 enhanced AR transcriptional activity. In clinical prostate tissue, we found strong RAC 3 mRNA expression and immuno-histochemistry demonstrated that in benign tissue, the protein was expressed predominantly in luminal cells, while in primary malignant epithelium it was more homogeneously expressed. In a series of 37 patients, the levels of RAC 3 expression correlated significantly with tumour grade (P = 0.01) and stage of disease (P = 0.03) but not with serum PSA levels. In addition moderate or high RAC 3 expression was associated with poorer disease-specific survival (P = 0.03). We conclude that RAC 3 is an important co-activator of the AR in the prostate and may have an important role in the progression of prostate cancer.
5. Optimal therapy for small nonc1eaved cell lymphoma (1993)

Small noncleaved lymphoma (SNCL) is a high grade diffuse lymphoma. It has also been known as diffuse undifferentiated lymphoma, and according to the Working' Formulation for non-Hodgkin's lymphoma is subdivided into Burkitt's and non-Burkitt's types [1]. While occurring infrequently relative to other non-Hodgkin's lymphomas, SNCL is of particular interest because it is a model of a biologically aggressive, yet curable neoplasm [2-4]. If patients with this lymphoma receive no treatment or ineffective treatment, they die rapidly, with a median survival measured in months. Small noncleaved cell lymphoma occurs most frequently in children and has been best studied in this group. However, several recent series have reported the clinical features and results of treatment in adults with SNCL. In this chapter we briefly describe the important clinical and pathologic features of SNCL. The major focus of the chapter is on treatment results; we first discuss the development of successful treatment in children and then examine results in adult patients using principles of therapy found effective in children. The chapter concludes with our recommendations for current therapy of adult SNCL.