gebhart/patrepeval huggingface dataset:
Golimumab — a new tool in the armoury against inflammatory arthritis (2011)

The development of biological drugs blocking tumour necrosis factor-alpha (TNF-α) has had a dramatic impact on the treatment of inflammatory arthritis in recent years. Golimumab is a fully human monoclonal antibody which inhibits TNF-α. It is licensed for the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. In this review we evaluate the results of phase III studies using golimumab and explore the place of golimumab in the treatment of these diseases.
Developing Therapies for Peanut Allergy (2014)

Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern worldwide. Currently, no routine immunotherapy is available to treat this often severe and sometimes fatal food allergy. Traditional subcutaneous allergen immunotherapy with crude peanut extracts has proven not feasible due to the high risk of severe systemic side effects. The allergen-specific approaches under preclinical and clinical investigation comprise subcutaneous, oral, sublingual and epicutaneous immunotherapy with whole-peanut extracts as well as applications of hypoallergenic peanut allergens or T cell epitope peptides. Allergen-nonspecific approaches include monoclonal anti-IgE antibodies, TCM herbal formulations and Toll-like receptor 9-based immunotherapy. The potential of genetically engineered plants with reduced allergen levels is being explored as well as the beneficial influence of lactic acid bacteria and soybean isoflavones on peanut allergen-induced symptoms. Although the underlying mechanisms still need to be elucidated, several of these strategies hold great promise. It can be estimated that individual strategies or a combination thereof will result in a successful immunotherapy regime for peanut-allergic individuals within the next decade.
Nanoimprint Lithography: Methods and Material Requirements (2007)

Abstract Nanoimprint lithography (NIL) is a nonconventional lithographic technique for high‐throughput patterning of polymer nanostructures at great precision and at low costs. Unlike traditional lithographic approaches, which achieve pattern definition through the use of photons or electrons to modify the chemical and physical properties of the resist, NIL relies on direct mechanical deformation of the resist material and can therefore achieve resolutions beyond the limitations set by light diffraction or beam scattering that are encountered in conventional techniques. This Review covers the basic principles of nanoimprinting, with an emphasis on the requirements on materials for the imprinting mold, surface properties, and resist materials for successful and reliable nanostructure replication.
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3 (2004)

The transient receptor potential (TRP) superfamily contains a large number of proteins encoding cation permeable channels that are further divided into TRPC (canonical), TRPM (melastatin), and TRPV (vanilloid) subfamilies. Among the six TRPV members, TRPV1, TRPV2, TRPV3, and TRPV4 form heat-activated cation channels, which serve diverse functions ranging from nociception to osmolality regulation. Although chemical activators for TRPV1 and TRPV4 are well documented, those for TRPV2 and TRPV3 are lacking. Here we show that in the absence of other stimuli, 2-aminoethoxydiphenyl borate (2APB) activates TRPV1, TRPV2, and TRPV3, but not TRPV4, TRPV5, and TRPV6 expressed in HEK293 cells. In contrast, 2APB inhibits the activity of TRPC6 and TRPM8 evoked by 1-oleolyl-2-acetyl-sn-glycerol and menthol, respectively. In addition, low levels of 2APB strongly potentiate the effect of capsaicin, protons, and heat on TRPV1 as well as that of heat on TRPV3 expressed in Xenopus oocytes. In dorsal root ganglia neurons, supra-additive stimulations were evoked by 2APB and capsaicin or 2APB and acid. Our data suggest the existence of a common activation mechanism for TRPV1, TRPV2, and TRPV3 that may serve as a therapeutic target for pain management and treatment for diseases caused by hypersensitivity and temperature misregulation.
Lossless wavelet based image compression with adaptive 2D decomposition (1996)

Critical congenital heart disease may require advanced knowledge and echocardiographic techniques for diagnosis. Pulse oximetry and telemedicine should also be incorporated in the diagnostic algorithm. Improvement in these factors might contribute to reducing the late detection of CCHD.
Biological mechanisms of bevacizumab-associated adverse events (2009)

The perception that inhibition of cancer-associated angiogenesis would be an effective treatment strategy was based on the fundamental difference in cell cycle activity between neoplastic and normal endothelial cells. Selective targeting of tumor vessels could have additional benefits, such as circumventing development of acquired resistance to these types of agents, overcoming intrinsic tumor resistance, exhibiting broad anti-tumor activity and decreasing normal tissue toxicity. Successful translation of anti-angiogenic therapy into the clinical setting was achieved only 5 years ago with the approval of bevacizumab for metastatic colorectal cancer. Although the benefits demonstrated in clinical trials led to the approval of bevacizumab for treatment of colorectal, lung and breast cancers, and most recently glioblastoma, a number of serious soft-tissue and vascular toxicities have also been observed in patients receiving this anti-angiogenic agent. This review assesses the relationship between inhibition of VEGF and toxicity, and proposes the pathogenic mechanisms that lead to the adverse events.
Pathogenesis and treatment of Clostridium difficile infection (2005)

This paper reviews the pathogenesis and management of Clostridium difficile diarrhoea, in particular the management of recurrent episodes.
Immunocytochemical and Physiological Characterization of a Population of Cultured Human Neural Precursors (2000)

Human neural precursor cells (HNPC) have recently become commercially available. In an effort to determine the usefulness of these cells for in vitro studies, we have grown cultured HNPCs (cHNPCs) according to the supplier specifications. Here we report our characterization of cHNPCs under nondifferentiating and differentiating growth conditions and make a comparison to primary HNPCs (pHNPCs) obtained at the same developmental time point from a different commercial supplier. We found that under nondifferentiating conditions, cHNPCs expressed nestin, divided rapidly, expressed few markers of differentiated cells, and displayed both 4-aminopyridine (4-AP)-sensitive and delayed-rectifier type K(+) currents. No inward currents were observed. On changing to differentiating culture conditions, a majority of the cells expressed neuronal markers, did not divide, expressed inward and outward time- and voltage-dependent currents, and responded to the application of the neurotransmitters acetylcholine and glutamate. The outward current densities were indistinguishable from those in undifferentiated cells. The inward currents included TTX-sensitive and -resistant Na(+) currents, sustained Ca(2+) currents, and an inwardly rectifying K(+) current. Comparison of the properties of differentiated cells from cHNPCs with neurons obtained from primary fetal cultures (pHNPCs) revealed two major differences: the differentiated cHNPCs did not express embryonic neural cell adhesion molecule (E-NCAM) immunoreactivity but did co-express GFAP immunoreactivity. The co-expression of neuronal and glial markers was likely due to the growth of cells in serum containing medium as the pHNPCs that were never exposed to serum did express E-NCAM and did not co-express glial fibrillary acidic protein (GFAP). The relevance of these results is discussed and compared with results from other neuronal progenitor populations and cultured human neuronal cells.
Post-polymerization functionalization of poly(3,4-propylenedioxythiophene) (PProDOT) via thiol–ene “click” chemistry (2015)

The surface functionalization of conjugated polymers such as the poly(alkoxythiophenes) poly(3,4-ethylenedioxythiophene) (PEDOT) and poly(3,4-propylenedioxythiophene) (PProDOT) provides a potential means for systematically tailoring their physical properties. We previously reported the synthesis of an alkene-functionalized 3,4-propylenedioxy-thiophene (ProDOT) derivative that could be readily modified through thiol-ene "click" chemistry. Here, we investigated the post-polymerization modification of PProDOT surfaces by using a dialkene functionalized variant (ProDOT-diene). The chemical structure of the ProDOT-diene monomer was confirmed by Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared spectroscopy (FTIR). The ProDOT-diene monomer was either chemically or electrochemically polymerized into the PProDOT-diene polymer, and then subsequently modified with alkyl, PEG, or ferrocene moieties via radical-based thiol-ene chemistry. We found that the normally insoluble PProDOT-diene could be converted into a soluble derivative by grafting alkyl groups onto the polymer chains after chemical polymerization. When electrochemically deposited on indium-tin oxide (ITO) glass electrodes, the conductivity, electroactivity and contact angles of the modified PProDOT-diene films could be tuned over a broad range. Scanning Electron Microscopy (SEM) revealed that post-polymerization modification did not significantly alter the surface morphology of the PProDOT-diene films. Overall, this method allows for efficient, facile tuning of the surface chemistry of poly(alkylthiophene) films, making it possible to tailor properties such as conductivity and wettability for different applications.
Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science (2001)

Based on fundamental chemistry, biotechnology and materials science have developed over the past three decades into today's powerful disciplines which allow the engineering of advanced technical devices and the industrial production of active substances for pharmaceutical and biomedical applications. This review is focused on current approaches emerging at the intersection of materials research, nanosciences, and molecular biotechnology. This novel and highly interdisciplinary field of chemistry is closely associated with both the physical and chemical properties of organic and inorganic nanoparticles, as well as to the various aspects of molecular cloning, recombinant DNA and protein technology, and immunology. Evolutionary optimized biomolecules such as nucleic acids, proteins, and supramolecular complexes of these components, are utilized in the production of nanostructured and mesoscopic architectures from organic and inorganic materials. The highly developed instruments and techniques of today's materials research are used for basic and applied studies of fundamental biological processes.
Primary Angle-Closure Glaucoma in Asia (2001)

Chew, Paul T. K. FRCS(Ed), FRCOphth*†; Aung, Tin FRCS(Ed), FRCOphth† Author Information
Monitoring California's Hardwood Rangelands Using Remotely Sensed Data (2002)

As human and natural forces continue to alter the hardwood landscape, resource agencies, county planners and local interest groups find it increasingly important to monitor and assess these alterations. The California Land Cover Mapping and Monitoring Program (LCMMP), a
A Brain System for Procedural Memory (2002)

Abstract Researchers have divided procedural memory into two general types. One type involves the acquisition of habits and skills, the capacity for a very broad variety of stereotyped and unconscious behavioral repertoires. The other type of procedural memory involves specific sensory-to-motor adaptations, that is, adjustments of reflexes, such as changing the force exerted to compensate for a new load, or acquisition of conditioned reflexes that involve novel motor responses to a new sensory contingency. This chapter analyzes the brain systems that support these two types of unconscious learning. It shows that procedural learning is mediated by a complex circuitry involving the motor cortical areas and two main subcortical loops, one through the striatum and another through the cerebellum.
Expression of Opioid Growth Factor (OGF)–OGF Receptor (OGFr) Axis in Human Nonmedullary Thyroid Cancer (2008)

The finding that a potent negative growth regulator and its receptor are present in nonmedullary thyroid cancers and thyroid tissues from patients with nonmalignant disease lead us to suggest that the OGF-OGFr axis serves as a regulator of cell proliferation in these tissues. Moreover, modulation of this biological system may be used to treat progression of nonmedullary thyroid neoplasias.
CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields (2009)

The widely used CHARMM additive all-atom force field includes parameters for proteins, nucleic acids, lipids, and carbohydrates. In the present article, an extension of the CHARMM force field to drug-like molecules is presented. The resulting CHARMM General Force Field (CGenFF) covers a wide range of chemical groups present in biomolecules and drug-like molecules, including a large number of heterocyclic scaffolds. The parametrization philosophy behind the force field focuses on quality at the expense of transferability, with the implementation concentrating on an extensible force field. Statistics related to the quality of the parametrization with a focus on experimental validation are presented. Additionally, the parametrization procedure, described fully in the present article in the context of the model systems, pyrrolidine, and 3-phenoxymethylpyrrolidine will allow users to readily extend the force field to chemical groups that are not explicitly covered in the force field as well as add functional groups to and link together molecules already available in the force field. CGenFF thus makes it possible to perform "all-CHARMM" simulations on drug-target interactions thereby extending the utility of CHARMM force fields to medicinally relevant systems.
CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells (1996)

In our search for cell surface markers expressed on hematopoietic stem cells and/or very early progenitor cells we found that the Joro 177 monoclonal antibody (MoAb) bound to most hematopoietic cells in day 8/8.5 yolk sac, day 12 fetal liver, and day 13 fetal thymocytes; it stained hematopoietic stem cells and less immature lymphoid, myeloid, and erythroid-lineage cells, but not most thymocytes and splenic lymphocytes in adult mice. Joro 177 MoAb stimulated tyrosine phosphorylation of an integral of 124-kD protein and induced homotypic aggregation of lymphoid progenitor cells. Importantly, Joro 177 MoAb inhibited cell survival/growth and consequently the generation of lymphoid, myeloid, and erythroid lineage cells in vitro from early Lin- hematopoietic precursors. Joro 177 MoAb induced apoptosis of hematopoietic progenitor cells. Molecular cloning and expression indicated that Joro 177 MoAb recognizes a type II transmembrane protein, which is the mouse homologue of the human CD98 heavy chain gene. We suggest that CD98 is a cell membrane receptor involved in the control of cell survival/death of hematopoietic cells.
ANTICIPATION IN MYOTONIC DYSTROPHY: FACT OR FICTION? (1989)

SUMMARY In 1918 Fleischer reported that after transmission from one generation to the next, myotonic dystrophy has an earlier onset and is more severe. The hypothesis put forward by Penrose in 1948 that ‘anticipation’ is caused by bias of index case selection was based on theoretical arguments only and has not been supported by clinical observations This hypothesis was tested in a clinical and genetic study of 14 families with myotonic dystrophy. Excluding index patients, an earlier onset in the child was found in 98% of 61 parent-child paris. A greater mean difference in age of onset was found with transmission via the father than via the mother The comparison of the seventy of the disease between parents and children was difficult because of the variation in symptoms but, in general, the disease was more severe in the child than in the parent The penetrance of the abnormal gene was nearly complete in the 14 families combined, leaving little room for the observation of ‘complementary’ parent-child pairs in the future Also in retrospect no complementary parent-child pairs were found in the first generations. Fertility was severely reduced only in the very early onset patient group and this selective infertility cannot be responsible for the total amount of anticipation observed. It is therefore concluded that anticipation may be inherent in the transmission of myotonic dystrophy This has important consequences for genetic counselling.
Inhibition of the Replication of a Hepatitis C Virus-Like RNA Template by Interferon and 3′-Deoxycytidine (2002)

The development of low molecular weight inhibitors of hepatitis C virus (HCV) replication has been hindered by the lack of a good cell-based system that models the entire HCV replication cycle. To date the only two therapies approved for the treatment of HCV infection are interferon (IFN)-alpha and the nucleoside analogue, ribavirin. We have created a cell-based system that allows for the accurate quantification of the replication of an HCV-like RNA template by proteins that are encoded for by the HCV genome. The system consists of a cell line that constitutively produces luciferase in response to the production of functional HCV replicative proteins. The 293B4alpha cell line has been formatted into a semi-high throughput, cell-based screen for inhibitors of HCV replication. When these cells were treated with either IFN-alpha or -beta, luciferase production decreased in a dose-responsive manner. Counterscreening these molecules in another cell line, 293SVLuc, in which luciferase production in not dependent the presence of functional HCV proteins, showed that the inhibition of luciferase in the 293B4alpha cell line was due to inhibition of the replication of the HCV-like RNA template and not anti-cellular or -luciferase activity. Moreover, when the 293B4alpha cell line was treated with the ribonucleoside analogue, 3'-deoxycytidine, luciferase decreased in a dose-responsive manner. 3'-deoxyguanosine and 3'-deoxyuridine did not inhibit luciferase production and 3'-deoxyadenosine was too cytotoxic to determine if it had any anti-HCV activity.
Boron-Nitrogen Compounds. XIV. The Preparation of Vinyldibromoborane and Some of Its Reactions with Amines (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBoron-Nitrogen Compounds. XIV. The Preparation of Vinyldibromoborane and Some of Its Reactions with AminesPeter Fritz, Kurt Niedenzu, and John W. DawsonCite this: Inorg. Chem. 1964, 3, 5, 626–627Publication Date (Print):May 1, 1964Publication History Published online1 May 2002Published inissue 1 May 1964https://pubs.acs.org/doi/10.1021/ic50015a003https://doi.org/10.1021/ic50015a003research-articleACS PublicationsRequest reuse permissionsArticle Views147Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Follistatin expression in ES and F9 cells and in preimplantation mouse embryos (1994)

Activins are thought to play a role in mesoderm induction in amphibian development. Studies of the expression patterns of activin during mouse embryogenesis are consistent with the proposal that they are also involved in mesoderm formation in mammals. Activins are expressed both maternally and zygotically at preimplantation stages, and at postimplantation stages transcripts are present at high levels in the deciduum, suggesting that mesoderm is induced by maternally-derived activin. The functions of activin can be modulated by follistatin. At postimplantation stages follistatin is expressed in the deciduum in a pattern reciprocal to that of activin. In the embryo proper, follistatin transcripts are localized to the primitive streak region during gastrulation and later in the somites and in rhombomeres 2, 4 and 6 of the hindbrain. In this paper we show that follistatin, like activin, is expressed throughout pre-implantation mouse development. Transcripts are present at low levels in undifferentiated F9 and ES cells, but they increase greatly on differentiation of both cell types. Expression of activin mRNA is decreased in differentiated F9 and ES cells, and the simultaneous increase in follistatin may create an efficient and rapid means of decreasing levels of functional activin.
Expected Information as Expected Utility (1979)

The normative procedure for the design of an experiment is to select a utility function, assess the probabilities, and to choose that design of maximum expected utility. One difficulty with this view is that a scientist typically does not have, nor can be normally expected to have, a clear idea of the utility of his results. An alternative is to design an experiment to maximize the expected information to be gained from it. In this paper we show that the latter view is a special case of the former with an appropriate choice of the decision space and a reasonable constraint on the utility function. In particular, the Shannon concept of information is seen to play a more important role in experimental design than was hitherto thought possible.
Detection of ESKAPE Bacterial Pathogens at the Point of Care Using Isothermal DNA-Based Assays in a Portable Degas-Actuated Microfluidic Diagnostic Assay Platform (2016)

This paper describes a portable system for rapidly identifying bacteria in resource-limited environments; we highlight the capabilities of the technology by detecting different pathogens within the ESKAPE collection, which cause nosocomial infections. The system is designed around isothermal DNA-based assays housed within an autonomous plastic cartridge that are designed with the end user in mind, who may have limited technological training. Displaying excellent sensitivity and specificity, the assay systems that we demonstrate may enable future diagnoses of bacterial infection to guide the development of effective chemotherapies and may have a role in areas beyond health where rapid detection is valuable, including in industrial processing and manufacturing, food security, agriculture, and water quality testing.