gebhart/patrepeval huggingface dataset:
Intramolecular triplet energy transfer. 3. A carbazole-naphthalene system having short chain length methylene spacer units (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular triplet energy transfer. 3. A carbazole-naphthalene system having short chain length methylene spacer unitsGregory W. Haggquist, Hideaki Katayama, Akira Tsuchida, Shinzaburo Ito, and Masahide YamamotoCite this: J. Phys. Chem. 1993, 97, 37, 9270–9273Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/j100139a003https://doi.org/10.1021/j100139a003research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Comparing the efficacy of preemptive intravenous paracetamol on the reducing effect of opioid usage in cholecystectomy. (2013)

In conclusion, preemptive iv paracetamol provided effective and reliable pain control after cholecystectomy surgeries and reduced post-operative pain scores, the need for and use of supplementary opioids and the time to first request of analgesics.
Allelic variation and heterosis in maize: How do two halves make more than a whole? (2007)

In this review, we discuss the recent research on allelic variation in maize and possible implications of this work toward our understanding of heterosis. Heterosis, or hybrid vigor, is the increased performance of a hybrid relative to the parents, and is a result of the variation that is present within a species. Intraspecific comparisons of sequence and expression levels in maize have documented a surprisingly high level of allelic variation, which includes variation for the content of genic fragments, variation in repetitive elements surrounding genes, and variation in gene expression levels. There is evidence that transposons and repetitive DNA play a major role in the generation of this allelic diversity. The combination of allelic variants provides a more comprehensive suite of alleles in the hybrid that may be involved in novel allelic interactions. A major unresolved question is how the combined allelic variation and interactions in a hybrid give rise to heterotic phenotypes. An understanding of allelic variation present in maize provides an opportunity to speculate on mechanisms that might lead to heterosis. Variation for the presence of genes, the presence of novel beneficial alleles, and modified levels of gene expression in hybrids may all contribute to the heterotic phenotypes.
ω‐Aminopropyl‐pyrazole durch Ringtransformation von Enaminonen der Pyrrolidinreihe (1988)

Abstract Enaminone der Pyrrolidinreihe 1 mit semicyclischer CC‐Bindung setzen sich mit Hydrazinsulfat unter Ringtransformation zu 5‐ω‐Aminopropyl‐pyrazolen 3 um, deren Struktur spektroskopisch gesichert wird. Der EI‐induzierte massenspektroskopische Zerfall von 3 wird durch B/E linked scan‐Untersuchungen belegt. 3d läßt sich durch Reaktion mit Cyanamid und nachfolgend Acetylaceton in das N‐Pyrimidino‐3‐pyrazolylpropylamin 4 überführen. Die antidepressive Wirkung der Titelverbindungen wird am Amphetamin induzierten Verhalten der männlichen Ratte untersucht. 2 Verbindungen potenzieren das stereotype Verhalten, 1 Substanz wirkt als Antagonist.
Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model (2003)

Our findings suggest strongly that phage lysins protect animals from bacteraemia and death. Moreover, the simultaneous attack of the pneumococcal peptidoglycan by a lysozyme and an amidase leads to a remarkable effect through enhanced destruction of the bacterial cell wall. The benefits of therapy with enzybiotics against pneumococcus reported here might warrant the examination of alternative strategies for the treatment of diseases caused by clinically relevant pathogens.
Isolation of Temperature-sensitive Mutants of Adenovirus Type 5 (1971)

Summary Temperature-sensitive mutants of adenovirus type 5 have been isolated from virus stocks mutagenized by nitrous acid, hydroxylamine and 5-bromodeoxyuridine. The frequency of such mutants in the surviving fractions of nitrous acid and hydroxylamine-treated stocks was 8.4 and 9.6%, respectively, while it was around 0.55% in stocks of virus grown in 5-bromodeoxyuridine. Most of the mutants tested so far appear to be relatively stable and show little evidence of excessive leakiness or back mutation, and will be suitable for genetic analysis. Preliminary experiments show good complementation between four of these mutants, and they have been assigned to four complementation groups.
Suolo, vite ed altre colture di qualità: l'introduzione e la pratica dei concetti “terroir” e “zonazione” (2008)

The research of the cultural vocation is one of the most effective means for quality and typicality protection of the productions and, at the same time, to limit soil degradation. In particular, the study of &ldquo;terroir&rdquo;, i.e. the relationships between environment and product quality, highlights a local positivity of the resources, strongly linked to the specificity of origin environments. It must be fairly protect. The valorisation of terroir is mostly considered one of the greatest prospects of success for national agriculture within global market, because very often the quality crops become also reference crops and driving imaging for a territory. Actually the term &ldquo;total quality of territory&rdquo; is very useful; it means the territory managed in function of crops quality, soil and ecosystem conservation, environment healthiness and landscape beauty. The reconnaissance of the territory vocation needs the research of its peculiarities witch determine the uniqueness of that production area. Therefore the uniqueness of a terroir is a value added to the quality and it may be determining for the success of a cultivation. The &ldquo;zoning&rdquo; technique started from the introduction of terroir concept. It is the division of a territory in function of its ecopedological and geographic characteristics and checking the qualitative result of different species and varieties. In short, the climatic, pedological and crop information interact with productivity and quality of crops.Through the zoning, the constituents of terroir and the verification
Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit (1995)

Using computer modelling, we have identified some of the residues of the A subunit of cholera toxin (CT) and heat-labile toxin that are involved in NAD binding, catalysis, and toxicity. Here we describe the site-directed mutagenesis of the CT gene and the construction of CT mutants. Nine mutations of the A subunit gene were generated. Six of them encoded proteins that were fully assembled in the AB5 structure and were nontoxic; these proteins were CT-D53 (Val-53-->Asp), CT-K63 (Ser-63-->Lys), CT-K97 (Val-97-->Lys), CT-K104 (Tyr-104-->Lys), CT-S106 (Pro-106-->Ser), and the double mutant CT-D53/K63 (Val-53-->Asp, Ser-63-->Lys). Two of the mutations encoded proteins that were assembled into the AB5 structure but were still toxic; these proteins were CT-H54 (Arg-54-->His) and CT-N107 (His-107-->Asn). Finally, one of the mutant proteins, CT-E114 (Ser-114-->Glu), was unable to assemble the A and the B subunits and produced only the B oligomer. The six nontoxic mutants were purified from the culture supernatants of recombinant Vibrio cholerae strains and further characterized. The CT-K63 mutant, which was the most efficient in assembly of the AB5 structure, was used to immunize rabbits and was shown to be able to induce neutralizing antibodies against both the A and B subunits. This molecule may be useful for the construction of improved vaccines against cholera.
Multipotent hemopoietic progenitor cells in patients with systemic lupus erythematosus. (1988)

Hematologic abnormalities in patients with systemic lupus erythematosus (SLE) were studied before treatment, using an in vitro bone marrow progenitor cell assay. In 10 patients with SLE, there was a decrease in the number of multipotent hemopoietic colonies. Multipotent colony formation was suppressed by the addition of T cells from the patients with SLE. The culture supernatant of phytohemagglutinin stimulated SLE leukocytes had diminished activity to support the multipotent colony formation. These results suggest that the hematologic abnormalities in SLE occur at the multipotent stem cell level. The T cell mediated suppression of hemopoietic progenitor cells and the diminished activity of humoral factors released from SLE leukocytes may play some role in the pathogenesis of hematologic abnormalities in SLE.
Implantable radiators for cancer therapy by microwave hyperthermia (1980)

The treatment of cancer by the combined effects of heat and radiation or chemotherapy is a promising procedure which has attracted wide interest. Microwave radiation is one of the most useful techniques for creating thermal fields in tissue but its use is limited by the rapid attenuation of microwaves in propagation through the body. Consequently, the design of microwave radiators which can be hypodermically inserted into tissue or introduced via a body orifice has been undertaken by a number of investigators. We review this work, the results of in vitro and in vivo animal tests, and the present status and outlook for patient treatment by this method.
<title>Optoelectronically implemented neural network with a wavelet preprocessor</title> (1993)

An optoelectronic neural network based upon the Neocognitron paradigm has been implemented at JPL and successfully demonstrated for automatic target recognition for both focal plane array imageries and range-Doppler radar signatures. A novel feature of this neural network architectural design is the use of a shift-invariant multichannel Fourier optical correlation as a building block for iterative multilayer processing. An innovative bipolar neural weights holographic synthesis technique was utilized to implement both the excitatory and inhibitory neural functions and dramatically increase its discrimination capability. In order to further increase the optoelectronic Neocognitron's self-organization processing ability, a wavelet preprocessor has been developed for feature extraction preprocessing (orientation, size, location, etc.). The addition of this wavelet processor would enable the neocognitron to dynamically focus on the incoming targets based on their known features and result in higher discrimination and lower false alarm rate. The theoretical analysis of an orientation and scale selective wavelet is provided. A multichannel optoelectronic wavelet processor using an e- beam complex-valued wavelet filter is also presented. Experimental demonstrations of wavelet preprocessing for feature extraction are also provided.
Votación consultiva de los accionistas sobre la retribución de los consejeros (2011)

El presente trabajo resume los cambios introducidos en los ordenamientos ingles, americano y espanol tras las recientes modificaciones producidas en pro de una mayor transparencia en las retribuciones de los consejeros y concretamente en la votacion consultiva sobre el informe de retribuciones. ABSTRACT: This paper summarizes the changes introduced in English, American and Spanish regulations after the current modifications in favour of more transparency in the remuneration of the company directors, and specifically those alterations which affect the non-binding vote of the annual directors’ remuneration report
Highly birefringent photonic crystal fibers (2000)

We report a strongly anisotropic photonic crystal fiber. Twofold rotational symmetry was introduced into a single-mode fiber structure by creation of a regular array of airholes of two sizes disposed about a pure-silica core. Based on spectral measurements of the polarization mode beating, we estimate that the fiber has a beat length of approximately 0.4 mm at a wavelength of 1540 nm, in good agreement with the results of modeling.
Calcium Supplements and Colorectal Adenomas (1999)

Experimental and observational findings suggest that calcium intake may protect against colorectal neoplasia. To investigate this hypothesis, we conducted a randomized, double-blind trial of colorectal adenoma recurrence. Nine hundred thirty patients with a recent history of colorectal adenomas were randomly given calcium carbonate (3 gm daily; 1200 mg elemental calcium) or placebo, with follow-up colonoscopies one and four years after the qualifying examination. The main analysis focused on new adenomas found after the first follow-up endoscopy, up to (and including) the second follow-up examination. Risk ratios of at least one recurrent adenoma and ratios of the average numbers of adenomas were calculated as measures of calcium effect. There was a lower risk of recurrent adenomas in subjects assigned calcium. Eight hundred thirty-two patients had two follow-up examinations and were included in the main analysis; the adjusted risk ratio of one or more adenomas was 0.81 (95% CI 0.67 to 0.99); the adjusted ratio of the average numbers of adenomas was 0.76 (95% CI 0.60 to 0.96). Among subjects who had at least one follow-up colonoscopy, the adjusted risk ratio of one or more recurrent adenomas was 0.85 (95% CI 0.74 to 0.98). The effect of calcium seemed independent of initial dietary fat and calcium intake. No toxicity was associated with supplementation. These findings indicate that calcium supplementation has a modest protective effect against colorectal adenomas, precursors of most colorectal cancers.
Approach to artificial mitochondria and highly functional artificial organ devices (2003)

The coupled reactions of the cytochrome-C(Cyt-C)-immobilized electrode and oxidoreductase, e.g. cytochrome oxidase and diachorase, were examined using horse heart mitochondrial Cyt. C. Diaphorase from Bacillus stearothermophilus was coated on In/sub 2/O/sub 3//SnO/sub 2/ (ITO) electrodes. The polymer-coated electrodes were applied to Cyt. C phosphate-buffered solution (pH 7.4) for cyclic voltammetric analysis. The electron transfer of the immobilized Cyt. C turned out to be ionically controlled. Biochemical assays of immobilized Cyt. C with cytochrome oxidase indicated that apparent cathodic currents of Cyt. C decrease with ionic strength (IS), but that cathodic current per molecule decrease with IS. The electron transfer activity of an immobilized Cyt. C molecule is found to be closely correlated to apparent diffusion constant. The phenomenon suggests that fixed Cyt. C should have adequate rotary freedoml for electron transfer in mitochondrial inner membrane. Cyt. C loosely immobilized on the coated In/sub 2/O/sub 3//SnO/sub 2/ electrode also reacted with diachorase. Because the redox reaction of immobilized Cyt. C could be regulated by the electrode potential, it is though that electrochemical NADH oxidation results from mediation of immobilized Cyt. C. An optimal condition was examined for this coupling reaction.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Predicting rib fracture risk with whole-body finite element models: development and preliminary evaluation of a probabilistic analytical framework. (2012)

This study sought to develop a strain-based probabilistic method to predict rib fracture risk with whole-body finite element (FE) models, and to describe a method to combine the results with collision exposure information to predict injury risk and potential intervention effectiveness in the field. An age-adjusted ultimate strain distribution was used to estimate local rib fracture probabilities within an FE model. These local probabilities were combined to predict injury risk and severity within the whole ribcage. The ultimate strain distribution was developed from a literature dataset of 133 tests. Frontal collision simulations were performed with the THUMS (Total HUman Model for Safety) model with four levels of delta-V and two restraints: a standard 3-point belt and a progressive 3.5-7 kN force-limited, pretensioned (FL+PT) belt. The results of three simulations (29 km/h standard, 48 km/h standard, and 48 km/h FL+PT) were compared to matched cadaver sled tests. The numbers of fractures predicted for the comparison cases were consistent with those observed experimentally. Combining these results with field exposure informantion (ΔV, NASS-CDS 1992-2002) suggests a 8.9% probability of incurring AIS3+ rib fractures for a 60 year-old restrained by a standard belt in a tow-away frontal collision with this restraint, vehicle, and occupant configuration, compared to 4.6% for the FL+PT belt. This is the first study to describe a probabilistic framework to predict rib fracture risk based on strains observed in human-body FE models. Using this analytical framework, future efforts may incorporate additional subject or collision factors for multi-variable probabilistic injury prediction.
ISABEL: a web-based differential diagnostic aid for paediatrics: results from an initial performance evaluation (2003)

ISABEL showed acceptable clinical accuracy in producing the final diagnosis for a variety of real as well as hypothetical case scenarios.
Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age (2008)

Age-related ovarian failure in women heralds the transition into postmenopausal life, which is characterized by a loss of fertility and increased risk for cardiovascular disease, osteoporosis and cognitive dysfunction. Unfortunately, there are no options available for delaying loss of ovarian function with age in humans. Rodent studies have shown that caloric restriction (CR) can extend female fertile lifespan; however, much of this work initiated CR at weaning, which causes stunted adolescent growth and a delayed onset of sexual maturation. Herein we tested in mice if CR initiated in adulthood could delay reproductive aging. After 4 months of CR, the ovarian follicle reserve was doubled compared to ad libitum (AL)-fed age-matched controls, which in mating trials exhibited a loss of fertility by 15.5 months of age. In CR females returned to AL feeding at 15.5 months of age, approximately one-half remained fertile for 6 additional months and one-third continued to deliver offspring through 23 months of age. Notably, fecundity of CR-then-AL-fed females and postnatal offspring survival rates were dramatically improved compared with aging AL-fed controls. For example, between 10 and 23 months of age, only 22% of the 54 offspring delivered by AL-fed females survived. In contrast, over 73% of the 94 pups delivered by 15.5- to 23-month-old CR-then-AL-fed mice survived without any overt complications. These data indicate that in mice adult-onset CR maintains function of the female reproductive axis into advanced age and dramatically improves postnatal survival of offspring delivered by aged females.
Acyl Carrier Protein (1970)

Abstract β-Ketoacyl acyl carrier protein (ACP) synthetase, which catalyzes the condensation of fatty acyl-ACP with malonyl-ACP to form β-ketoacyl-ACP, has been crystallized in a highly active form which is stable for several months. Phosphate has been shown to cause enzyme activation which may be due to a conformational change of the protein. Guanidine hydrochloride and sodium dodecyl sulfate have been shown to cause dissociation of the active enzyme into inactive subunits. By several methods the subunit molecular weight was found to be approximately 34,000. This and other data suggest that the subunits are similar and perhaps identical. Enzymatic activity can be partially recovered from guanidine hydrochloride-denatured enzyme.
Architecture for Protecting Critical Secrets in Microprocessors (2005)

We propose “secret-protected (SP)” architecture to enable secure and convenient protection of critical secrets for a given user in an on-line environment. Keys are examples of critical secrets, and key protection and management is a fundamental problem - often assumed but not solved - underlying the use of cryptographic protection of sensitive files, messages, data and programs. SP-processors contain a minimalist set of architectural features that can be built into a general-purpose microprocessor to provide protection of critical secrets and their computations, without expensive or inconvenient auxiliary hardware. SP-architecture also requires a trusted software module, a few modifications to the operating system, a secure I/O path to the user, and a secure installation process. Unique aspects of our architecture include: decoupling of user secrets from the devices, enabling users to securely access their keys from different networked computing devices; the use of symmetric master keys rather than more costly public-private key pairs; and the avoidance of any permanent or factory-installed device secrets.
The Attention System of the Human Brain (1990)

The brain's default mode network consists of discrete, bilateral and symmetrical cortical areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal cortices of the human, nonhuman primate, cat, and rodent brains. Its ...Read More
Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity (2000)

Continuing structure-activity studies were performed on the 2,3,4, 5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine farnesyltransferase (FT) inhibitors. These studies demonstrated that a 3(R)-phenylmethyl group, a hydrophilic 7-cyano group, and a 4-sulfonyl group bearing a variety of substituents provide low-nanomolar FT inhibitors with cellular activity at concentrations below 100 nM. Maximal in vivo activity in the mutated K-Ras bearing HCT-116 human colon tumor model was achieved with analogues carrying hydrophobic side chains such as propyl, phenyl, or thienyl attached to the N-4 sulfonyl group. Several such compounds achieved curative efficacy when given orally in this model. On the basis of its excellent preclinical antitumor activity and promising pharmacokinetics, compound 20 (BMS-214662, (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thie nyl sulfonyl)-1H-1,4-benzodiazepine) has been advanced into human clinical trials.