gebhart/patrepeval huggingface dataset:
Antioxidant metabolite profiles in tomato fruit constitutively expressing the grapevine stilbene synthase gene (2004)

Tomato (Lycopersicon esculentum Mill.) tissues were transformed with a grape (Vitis vinifera L.) stilbene synthase cDNA, transcriptionally regulated by the cauliflower mosaic virus (CaMV) 35S promoter. Transgenic plants accumulated new compounds, not present in either wild-type or vector-transformed plants. These were identified, by high-pressure liquid chromatography, as trans-resveratrol and trans-resveratrol-glucopyranoside. The amounts of trans-resveratrol and its piceid form were evaluated in the transgenic fruit. It was found that the content of the metabolite varied during fruit maturation to up to 53 microg/g fresh weight of total trans-resveratrol at the red stage of ripening. This metabolite accumulation was possibly dependent on a combination of sufficiently high levels of stilbene synthase and the availability of substrates. With the aim of verifing the metabolic impairment, the amounts of chlorogenic acid and naringenin in both transgenic and wild-type ripening fruit were compared and no dramatic variation in the synthesis profile of the two metabolites was noted. To our knowledge, no data are available on the assessment of the effects of the expression of the StSy gene on other antioxidant compounds present in tomato fruit. To establish whether the presence of a novel antioxidant molecule affected the redox regulation in transgenic tomato fruit cells, the effect of resveratrol accumulation on the naturally present antioxidant pool was analysed. We showed that, in transgenic fruit which accumulate trans-resveratrol, there is an increase in the levels of ascorbate and glutathione, the soluble antioxidants of primary metabolism, as well as in the total antioxidant activity. Conversely, the content of tocopherol and lycopene, which are membrane-located antioxidants, is not affected. Consistent with the increased antioxidant properties, the lipid peroxidation was lower in transformed than in wild-type fruit.
Results of Treatment with Pollen Extract (Cernilton R N) in Chronic Prostatitis and Prostatodynia (1993)

We report the results of a prospective study with the pollen extract, Cernilton N, in a dose of 1 tablet tid for 6 months for the treatment of chronic prostatitis syndrome in 90 patients. The factors documented before and after 3 and 6 months' treatment were digital rectal examination (DRE) of the prostate, uroflowmetry, bacterial studies, leucocyte counts in urine and measurement of complement C3/coeruloplasmin in the seminal fluid. The patients were divided into 2 groups: those without associated complicating factors (CFs) (n = 72) and those with complicating factors, i.e. urethral strictures, prostatic calculi, bladder neck sclerosis (n = 18). In the group without CFs, 56 (78%) had a favorable response; 26 (36%) were cured of their symptoms and signs and 30 (42%) improved significantly with an increase in flow rate, a reduction in leukocyturia in the post-prostate massage urine (VB3) and a decrease in complement C3/coeruloplasmin in the ejaculate. In the patients with CFs only 1 patient showed a response. Complicating factors should be considered in patients who fail to respond to treatment within 3 months. Cernilton N was well tolerated by 97% of patients.
Botulinum A Toxin for Glabellar Wrinkles (1998)

There was no statistically significant difference in safety or efficacy for concentrations ranging from 50 to 200 U/ml of botulinum toxin.
Informatics Platform for Global Proteomic Profiling and Biomarker Discovery Using Liquid Chromatography-Tandem Mass Spectrometry (2004)

We have developed an integrated suite of algorithms, statistical methods, and computer applications to support large-scale LC-MS-based gel-free shotgun profiling of complex protein mixtures using basic experimental procedures. The programs automatically detect and quantify large numbers of peptide peaks in feature-rich ion mass chromatograms, compensate for spurious fluctuations in peptide signal intensities and retention times, and reliably match related peaks across many different datasets. Application of this toolkit markedly facilitates pattern recognition and biomarker discovery in global comparative proteomic studies, simplifying mechanistic investigation of physiological responses and the detection of proteomic signatures of disease.
Synthesis of Novel Thieno[2,3‐d]pyrimidine, Thieno[2,3‐b]pyridine and Thiazolo[3,2‐a]thieno[2,3‐d]pyrimidine Derivatives and Their Effect on the Production of Mycotoxins (1992)

The thiophene derivative 1 reacts with the active methylene reagents 2a-c to afford the thieno[2,3-d]pyrimidine derivatives 6a,b and 8, respectively. 1 reacts with phenacyl bromide 2d to afford the N-alkylation product 9 and reacts with phenacyl thiocyanate 2e to afford the N-(thiazol-2-yl) derivative 10, which was further cyclized into thiazolo[3,2-a]thieno[2,3-d]pyrimidine derivative 12. Compound 1 reacts also with the cinnamonitriles 3a,b to afford the thieno[2,3-b]pyridines 15a,b, respectively. 1 undergoes either acetylation or hydrolysis to afford the thieno[2,3-b]pyridine derivative 19 and the thiophene derivative 22, respectively. Some of the new compounds show inhibitory effect to the production of mycotoxins and to fungal growth.
Hofmeister Phenomena: An Update on Ion Specificity in Biology (2012)

CONTENTS\n1. Introduction—The Background to Hofmeister Effects\n1.1. A Caveat on Language: Progress in Theory\n1.2. Why Hofmeister Matters in Biology\n1.3. Hofmeister Series\n2. Molecular Interactions\n2.1. Backdrop of Classical Theoretical Ideas\n2.2. Interplay between Different Forces\n3. Specific Ion Effects in the Physical Chemistry of\nAqueous Solutions\n3.1. Viscosity\n3.2. Activity Coefficients\n3.3. pH and Buffers\n4. Correlations with Physico-Chemical Parameters:\nThe Law of Matching Water Affinities\n5. Hofmeister Effects in the Bulk Phase\n6. Hofmeister Effects in Surfactant and Polymer\nSystems and at Interfaces\n7. Hofmeister Effects in Proteins and Enzymes\n7.1. Proteins\n7.2. Enzymes\n8. Hofmeister Effects in Biology and Medicine\n9. The Other Side of the Coin. Future Perspectives:\nInterplay between Ion Specificity, Membrane\nOrganization, Protein Structure and Activity\n9.1. Specific Ion Effects at the Cellular Level\n9.2. Enzymes\n9.3. Bacterial Growth\n9.4. Inorganic Nanoparticle Effects\n9.5. Membrane Structural Changes\n10. Conclusions\nAuthor Information\nBiographies\nAcknowledgment\nReferences
A Molecular Yarn:  Near-Field Optical Studies of Self-Assembled, Flexible, Fluorescent Fibers (1996)

The formation of flexible molecular fibers via the solution-phase self-assembly of the pseudo-isocyanine dye (PIC) 1,1‘-diethyl-2,2‘-cyanine, and poly(vinyl sulfate) (PVS) is reported. The physical and electronic properties of these fibers spin-coated into thin films on fused-quartz substrates are studied by fluorescence and topographic imaging with near-field scanning optical microscopy (NSOM) and also by atomic force microscopy (AFM). The scanned-probe images demonstrate that fibers with lengths in the hundred micrometer range, widths of hundreds of nanometers, and thicknesses of a few tens of nanometers are readily formed in aqueous mixtures of PVS and PIC. Unprecedented flexibility in these fibers is exemplified by the formation of numerous curved and looped structures in the spin-coated thin films. A sandwich-like composite structure of alternating anionic PVS and cationic PIC layers is proposed as a model for the assembly of the dye and polymer in these fibers. The alternating layers in this model are held tightly together via the cooperative “cross-linking” of the PVS and PIC layers by electrostatic dye/polymer interactions, and by hydrophobic van der Waals interactions between the PIC molecules. The intermolecular interactions in the PIC layer result in the formation of a liquid-crystalline-like, well-ordered layer of the PIC which exhibits the spectral characteristics of J-aggregates. The proposed layered structure apparently possesses “reactive” surfaces which link individual fibers into a yarnlike assembly. This cross-linking effect is supported by the presence of continuous circular fibers and by the gel-forming ability of the solutions from which these fibers are grown.
<title>Advanced image processing for defect visualization in infrared thermography</title> (1998)

Results of a defect visualization process based on pulse IR thermography are presented. Algorithms have been developed to reduce the amount of operator participation required in the process of interpreting thermographic images. The algorithms determine the defect's depth and size from the temporal and spatial thermal distributions that exist on the surface of the investigated object following thermal excitation. A comparison of the result from thermal contrast, time derivative, and phase analysis methods for defect visualization are presented. These comparisons are based on 3D simulations of a test case representing a plate with multiple delaminations. Comparisons are also based on experimental data obtained from a specimen with flat bottom holes and a composite panel with delaminations.
Sleep disorders in substance abusers: how common are they? (2009)

Substance abuse is on the rise and affects every aspect of society. Our study has, for the first time, systematically evaluated various sleep disorders in these subjects who seem 5 to 10 times more likely to have sleep disorders. Diagnosing and treating sleep disorders will have a huge impact in inducing remission. However, this study has significant limitations, including a small number of subjects, subjective data collected via questionnaires, and no long-term follow up, which makes it difficult to draw conclusions.
Channel drop filters in photonic crystals (1998)

We present a general analysis of channel drop filter structures composed of two waveguides and an optical resonator system. We show that 100% transfer between the two waveguides can occur by creating resonant states of different symmetry, and by forcing an accidental degeneracy between them. The degeneracy must exist in both the real and imaginary parts of the frequency. Based on the analysis we present novel photonic crystal channel drop filters. Numerical simulations demonstrate that these filters exhibit ideal transfer characteristics.
Associating video frames with text (2003)

to solve the correspondence problem between video frames and associated text in order to annotate video frames with more reliable labels and descriptions. Visual features extracted from video frames are linked to text that is obtained from the audio transcripts using joint statistics. The results show that using this approach it is possible to have better annotations for video frames that can be later used to improve the performance of text based queries. The proposed approach will be integrated into the Informedia Digital Video Library Project at Carnegie Mellon University. 1.
Effect of daily topical ethacrynic acid on aqueous humor dynamics in monkeys (1995)

AbstractWe determined the effect of 1.5% ethacrynic acid (ECA) in ointment on intraocular pressure (IOP) and outflow facility following 5 days of topical treatment in ocular normotensive cynomolgus monkeys. Twelve monkeys received a 1 cm strip of ointment containing ECA in one eye but without ECA in the other once daily for 5 days. On Day 1 and Day 5 IOP was measured immediately before and 1 and 3 h after treatment. Outflow facility (perfusion) was determined 3.5 h after treatment on Day 5. The ECA-vehicle IOP differences averaged -2.8 ± 0.8 (S.E.M) (p < 0.01), -1.7 ± 0.6 (p < 0.02) and -3.7 ± 0.7 mm Hg (p < 0.001), equivalent to IOP reductions of 21 ± 6% (p < 0.01), 13 ± 5% (p < 0.02) and 26 ± 5% (p < 0.002) respectively, at 0, 1 and 3 h respectively after treatment on Day 5. Facility averaged 40 ± 15% higher (p < 0.03) in the ECA-treated compared to the vehicle-treated eyes 4 h after treatment on Day 5.Key Words: aqueous humor outflow facilityintraocular pressureethacrynic acidcynomolgus monkeymonkey eye
新PC：一“心”能两用 (2002)

北方的冬天说冷就冷。一阵寒流过来，气温就能一下子下降了十多度。e刀客这几天也减少了外出活动的时间，在网上苦做IT功课。现在临近年底。IT圈子里的年终盘点风又盛起。e刀客上网时老看到有这方面的文章。尽管e刀客对IT典故的了解、掌握在圈子里已小有名气，但想起几天前隔壁的王老师向自己打听电脑的市场情况。e刀客也就分外留意起这方面的情况来。
High-rate serially concatenated coding with extended hamming codes (2005)

This letter shows that concatenation of extended Hamming codes with rate-1 recursive convolutional encoder and iterative decoding achieves near Shannon limit performance for very high rate coding. These codes can be decoded efficiently, and have large adaptability in code lengths and code rates.
Fructose Intolerance: An Under-Recognized Problem (2003)

Fructose intolerance may cause unexplained GI symptoms. The higher yield of positive tests in our initial study may be due to referral bias or testing conditions; lower test dose produced a lower yield. Nonetheless, recognition and treatment of fructose intolerance may help many patients.
Platelet glycoprotein II/IIIa receptor inhibitors in ischemic heart disease (1995)

The key role of platelets in the pathogenesis of ischemic heart disease has led to the development of new classes of agents to control platelet function. The platelet glycoprotein IIb/IIIa receptor mediates the final common pathway to platelet aggregation. Drugs that block the glycoprotein IIb/IIIa receptor potently inhibit platelet aggregation. Monoclonal antibodies, cyclic peptides, and peptide-derivative glycoprotein IIb/IIIa inhibitors have been developed. The monoclonal antibody Fab fragment, chimeric 7E3, has been shown to significantly reduce ischemic complications and clinical restenosis after high-risk angioplasty in the large-scale Evaluation of 7E3 for the Prevention of Ischemic Complications (EPIC) trial. A number of glycoprotein IIb/IIIa inhibitors have been tested in patients with unstable angina with similarly positive results, and initial trials in patients with acute myocardial infarction are also encouraging. Further evaluation of these agents in large scale trials is currently underway and should help determine the place and appropriate use of these agents in the clinical arena.
Reciprocal Binding of CTCF and BORIS to the NY-ESO-1 Promoter Coincides with Derepression of this Cancer-Testis Gene in Lung Cancer Cells (2005)

Regulatory sequences recognized by the unique pair of paralogous factors, CTCF and BORIS, have been implicated in epigenetic regulation of imprinting and X chromosome inactivation. Lung cancers exhibit genome-wide demethylation associated with derepression of a specific class of genes encoding cancer-testis (CT) antigens such as NY-ESO-1. CT genes are normally expressed in BORIS-positive male germ cells deficient in CTCF and meCpG contents, but are strictly silenced in somatic cells. The present study was undertaken to ascertain if aberrant activation of BORIS contributes to derepression of NY-ESO-1 during pulmonary carcinogenesis. Preliminary experiments indicated that NY-ESO-1 expression coincided with derepression of BORIS in cultured lung cancer cells. Quantitative reverse transcription-PCR analysis revealed robust, coincident induction of BORIS and NY-ESO-1 expression in lung cancer cells, but not normal human bronchial epithelial cells following 5-aza-2'-deoxycytidine (5-azadC), Depsipeptide FK228 (DP), or sequential 5-azadC/DP exposure under clinically relevant conditions. Bisulfite sequencing, methylation-specific PCR, and chromatin immunoprecipitation (ChIP) experiments showed that induction of BORIS coincided with direct modulation of chromatin structure within a CpG island in the 5'-flanking noncoding region of this gene. Cotransfection experiments using promoter-reporter constructs confirmed that BORIS modulates NY-ESO-1 expression in lung cancer cells. Gel shift and ChIP experiments revealed a novel CTCF/BORIS-binding site in the NY-ESO-1 promoter, which unlike such sites in the H19-imprinting control region and X chromosome, is insensitive to CpG methylation in vitro. In vivo occupancy of this site by CTCF was associated with silencing of the NY-ESO-1 promoter, whereas switching from CTCF to BORIS occupancy coincided with derepression of NY-ESO-1. Collectively, these data indicate that reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter mediates epigenetic regulation of this CT gene in lung cancer cells, and suggest that induction of BORIS may be a novel strategy to augment immunogenicity of pulmonary carcinomas.
Successful Desensitization to Fixed Drug Eruption: The Presence of CD25+CD4+ T Cells in the Epidermis of Fixed Drug Eruption Lesions May Be Involved in the Induction of Desensitization (2004)

&lt;i&gt;Background:&lt;/i&gt; Fixed drug eruption (FDE) is a distinct type of drug-induced eruption, in which intraepidermal CD8+ T cells in the lesional skin are the final effector cells in the epidermal injury of FDE. Desensitization is a unique approach for the management of drug eruption, which has been reported to be effective in treating FDE. However, the mechanisms underlying desensitization to FDE are quite unknown. &lt;i&gt;Objective and Methods:&lt;/i&gt; We reported a case of successful desensitization to allopurinol-induced FDE. To clarify the mechanisms underlying desensitization to FDE, we examined the phenotype of T cells in the epidermis of FDE lesions before and after desensitization using flow cytometry. &lt;i&gt;Results:&lt;/i&gt; The overwhelming majority of intraepidermal T cells in the FDE lesion before desensitization consisted of CD8+ T cells, whereas a significant number of CD25+CD4+ T cells were present in the epidermis of FDE lesions after desensitization. &lt;i&gt;Conclusion:&lt;/i&gt; The presence of CD25+CD4+ T cells in the epidermis of FDE lesions may be involved in the induction of desensitization to FDE.
El profesional de la mediación (2017)

La normativa vigente atribuye a los mediadores unas funciones y un marco de trabajo en una organizacion en relacion con un entorno. De este marco de ocupacion se desprende un perfil competencial desarrollado en las formaciones especificas para ejercer la mediacion. Se plantea la reflexion si es el profesional que necesita la sociedad actual.
Extracellular Matrix Fibronectin Mechanically Couples Skeletal Muscle Contraction With Local Vasodilation (2007)

During exercise, local mechanisms in tissues cause arterioles to rapidly dilate to increase blood flow to tissues to meet the metabolic demands of contracting muscle. Despite decades of study, the mechanisms underlying this important aspect of blood flow control are still far from clear. We now report a novel mechanism wherein fibronectin fibrils in connective tissue matrices transduce signals from contracting skeletal muscle to local blood vessels to increase blood flow. Using intravital microscopy, we show that local vasodilation in response to skeletal muscle contraction is specifically inhibited by an antibody that recognizes the matricryptic site in the first type III repeat of fibronectin (FNIII-1). In the absence of skeletal muscle contraction, direct application of FNIII-1-containing fibronectin fragments to cremaster muscle arterioles in situ, triggered a rapid, specific, and reversible local dilation that was mediated by nitric oxide and required the cryptic, heparin-binding sequence of FNIII-1. Furthermore, application of function-blocking FNIII-1 peptides to cremaster muscle arterioles rapidly and specifically decreased their diameter, indicating that the matricryptic site of fibronectin also contributes to resting vascular tone. Alexa fluor 488-labeled fibronectin, administered intravenously, was rapidly assembled into elongated, branching fibrils in the extracellular matrix of intact cremaster muscle, demonstrating active polymerization of fibronectin in areas adjacent to blood vessels. Together, these data provide the first evidence that a matricryptic, heparin-binding site within fibronectin fibrils of adult connective tissue plays a dynamic role in regulating both vascular responses and vascular tone.
Lifestyle intervention to prevent diabetes in men and women with impaired glucose tolerance is cost-effective (2007)

Lifestyle intervention directed toward high-risk subjects would be cost-saving for the healthcare payer and highly cost-effective for society as a whole.
Clinical Trials with Mesenchymal Stem Cells: An Update (2016)

In the last year, the promising features of mesenchymal stem cells (MSCs), including their regenerative properties and ability to differentiate into diverse cell lineages, have generated great interest among researchers whose work has offered intriguing perspectives on cell-based therapies for various diseases. Currently the most commonly used adult stem cells in regenerative medicine, MSCs, can be isolated from several tissues, exhibit a strong capacity for replication in vitro, and can differentiate into osteoblasts, chondrocytes, and adipocytes. However, heterogeneous procedures for isolating and cultivating MSCs among laboratories have prompted the International Society for Cellular Therapy (ISCT) to issue criteria for identifying unique populations of these cells. Consequently, the isolation of MSCs according to ISCT criteria has produced heterogeneous, nonclonal cultures of stromal cells containing stem cells with different multipotent properties, committed progenitors, and differentiated cells. Though the nature and functions of MSCs remain unclear, nonclonal stromal cultures obtained from bone marrow and other tissues currently serve as sources of putative MSCs for therapeutic purposes, and several findings underscore their effectiveness in treating different diseases. To date, 493 MSC-based clinical trials, either complete or ongoing, appear in the database of the US National Institutes of Health. In the present article, we provide a comprehensive review of MSC-based clinical trials conducted worldwide that scrutinizes biological properties of MSCs, elucidates recent clinical findings and clinical trial phases of investigation, highlights therapeutic effects of MSCs, and identifies principal criticisms of the use of these cells. In particular, we analyze clinical trials using MSCs for representative diseases, including hematological disease, graft-versus-host disease, organ transplantation, diabetes, inflammatory diseases, and diseases in the liver, kidney, and lung, as well as cardiovascular, bone and cartilage, neurological, and autoimmune diseases.