gebhart/patrepeval huggingface dataset:
Impact of the Cell Cycle Progression Test on Physician and Patient Treatment Selection for Localized Prostate Cancer (2015)

The cell cycle progression test has a significant impact in assisting physicians and patients reach personalized treatment decisions.
The Biosynthesis of Linoleate from Oleoyl‐CoA via Oleoyl‐Phosphatidylcholine in Microsomes of Developing Safflower Seeds (1978)

Microsomes prepared from developing safflower seeds rapidly desaturated added [14C]oleoyl-CoA in the presence of NADH. The distribution of [14C]oleate and [14C]linoleate between different lipid classes revealed that phosphatidylcholine was labelled with [14C]linoleate before any other lipid class investigated. Considerable desaturation continued after the disappearance of [14C]oleoyl-CoA in the reaction mixture. No [14C]linoleoyl-CoA could be detected. Incubation in the absence of added NADH caused a rapid disappearance of [14C]oleoyl-CoA by incorporation into triacylglycerols and phosphatidylcholine and also by release as [14C]oleic acid. Upon subsequent addition of NADH, [14C]linoleate was formed to the same extent as when NADH was present at the onset of the incubation. These data are contradictory to the previously assumed pathway for linoleic acid biosynthesis in developing safflower seeds, claiming oleoyl-CoA as the direct substrate and linoleoyl-CoA as the primary product. However, our data corroborate published results on Chlorella, Candida, Torulopsis and on developing pea leaves, which strongly suggest that oleoyl-CoA is first incorporated into phosphatidylcholine and then desaturated to linoleoyl-phosphatidylcholine.
A brief overview of the present status of the mechanisms involved in electrospray mass spectrometry (2000)

A brief account of the mechanisms by which ions in solution are converted to ions in the gas phase is given on the basis of information available in the literature and the four companion articles on electrospray mass spectrometry (ESMS) in this issue. The following stages/phenomena are described: (a) production of the charged droplets at the ES capillary tip; (b) evolution of the charged droplets due to solvent evaporation and droplet fission caused by Coulombic repulsion of the charges on the droplets; production of the gas phase ion from very small charged droplets by the charge residue model (CRM) or the ion evaporation method (IEM); (c) dependence of the sensitivity in ESMS on the chemical nature of the analyte and its concentration as well as on the concentration of other electrolytes that are present in the solution; qualitative predictions on the sensitivity of the analyte based on the surface activity of the analyte ions; (d) relationship between ions produced in the gas phase and original ions present in the solution; and (e) globular proteins. Much of the information presented in (a)-(e) has been available for some time in the literature. However some significant advances are relatively recent. Recent results by de la Mora and co-workers, including their contribution in this Special Feature, provide very strong evidence that small ions (in distinction from macroions such as bio-macroions) are produced by IEM. On the other hand, macroions and particularly the polyprotonated globular proteins are produced by CRM. Also noteworthy is the development of an equation by Enke with which the observed relative ion signal intensities of the gas-phase ions produced can be predicted on the basis of the ion concentration in solution over a wide concentration range. The recognition that the sensitivity of organic analyte ions can be qualitatively predicted on the basis of the hydrophilicity or hydrophobicity of the part of the molecule that is not part of the charged (ionic) group and affects the surface activity of the ionic species is also noteworthy and a very useful relatively recent development.
Improvements to Uncalibrated Feature-Based Stereo Matching for Document Images by Using Text-Line Segmentation (2012)

Document images prove to be a difficult case for standard stereo correspondence approaches. One of the major problem is that document images are highly self-similar. Most algorithms try to tackle this problem by incorporating a global optimization scheme, which tends to be computationally expensive. In this paper, we show that incorporation of layout information into the matching paradigm, as a grouping entity for features, leads to better results in terms of robustness, efficiency, and ultimately in a better 3D model of the captured document, that can be used in various document restoration systems. This can be seen as a divide and conquer approach that partitions the search space into portions given by each grouping entity and then solves each of them independently. As a grouping entity text-lines are preferred over individual character blobs because it is easier to establish correspondences. Text-line extraction works reasonably well on stereo image pairs in the presence of perspective distortions. The proposed approach is highly efficient and matches obtained are more reliable. The claims are backed up by showing their practical applicability through experimental evaluations.
Glycosaminoglycans and the regulation of blood coagulation (1993)

Research Article| January 15 1993 Glycosaminoglycans and the regulation of blood coagulation M C Bourin; M C Bourin Search for other works by this author on: This Site PubMed Google Scholar U Lindahl U Lindahl †Laboratoire de Biotechnologie des Cellules Eucaryotes, Université Paris XII, 94010 Créteil, France and Department of Medical and Physiological Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1993) 289 (2): 313–330. https://doi.org/10.1042/bj2890313 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Citation M C Bourin, U Lindahl; Glycosaminoglycans and the regulation of blood coagulation. Biochem J 15 January 1993; 289 (2): 313–330. doi: https://doi.org/10.1042/bj2890313 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1993 The Biochemical Society, London1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Adsorption-Induced Conformational Changes of Antifreeze Glycoproteins at the Ice/Water Interface (2007)

The conformation of antifreeze glycoprotein (AFGP) molecules adsorbed at the ice/water interface was studied by attenuated total reflection (ATR)-FTIR spectroscopy. Measurements were carried out for AFGP/D2O solution films formed on the surface of an ATR prism as a function of temperature. Using the FTIR spectrum from the O-D stretching band of D2O molecules, we monitored the supercooled and frozen states of the film and measured the thickness of the quasi-liquid layer (QLL) at the ice/prism interfaces. The AFGP structure was determined for the liquid, supercooled, and frozen states of the solution film using the amide I band spectra. No noticeable differences in conformation were observed in the solution conformation from room temperature down to the 15 K supercooling studied, whereas the alpha-helical content of AFGP suddenly increased when the supercooled solution film froze at -15 degrees C. This change in conformation can increase the overall interaction between the AFGP molecules and ice surface and allow a stronger adsorption. In contrast, the alpha-helical content of AFGP in the frozen film gradually decreased with increasing temperature and finally returned to its solution-state level at the melting point of D2O ice. This gradual decrease in the alpha-helix content directly correlates with the measured increase in QLL thickness. Finally, we conclude that the differences in the alpha-helix signals between the frozen and supercooled states indicate the conformational change of AFGP molecules upon adsorption at the ice/water interface, emphasizing the importance of the structure-function relationship, even for this highly flexible antifreeze.
Structural and functional properties of heparin analogues obtained by chemical sulphation of Escherichia coli K5 capsular polysaccharide (1995)

Capsular polysaccharide from Escherichia coli K5, with the basic structure (GlcA beta 1-4GlcNAc alpha 1-4)n, was chemically modified through N-deacetylation, N-sulphation and O-sulphation [Casu, Grazioli, Razi, Guerrini, Naggi, Torri, Oreste, Tursi, Zoppetti and Lindahl (1994) Carbohydr. Res. 263, 271-284]. Depending on the reaction conditions, the products showed different proportions of components with high affinity for antithrombin (AT). A high-affinity subfraction, M(r) approx. 36,000, was shown by near-UV CD, UV-absorption difference spectroscopy and fluorescence to cause conformational changes in the AT molecule very similar to those induced by high-affinity heparin. Fluorescence titrations demonstrated about two AT-binding sites per polysaccharide chain, each with a Kd of approx. 200 nM. The anti-(Factor Xa) activity was 170 units/mg, similar to that of the IIId international heparin standard and markedly higher than activities of previously described heparin analogues. Another preparation, M(r) approx. 13,000, of higher overall O-sulphate content, exhibited a single binding site per chain, with Kd approx. 1 microM, and an anti-(Factor Xa) activity of 70 units/mg. Compositional analysis of polysaccharide fractions revealed a correlation between the contents of -GlcA-GlcNSO3(3,6-di-OSO3)- disaccharide units and affinity for AT; the 3-O-sulphated GlcN unit has previously been identified as a marker component of the AT-binding pentasaccharide sequence in heparin. The abundance of the implicated disaccharide unit approximately equalled that of AT-binding sites in the 36,000-M(r) polysaccharide fraction, and approached one per high-affinity oligosaccharide (predominantly 10-12 monosaccharide units) isolated after partial depolymerization of AT-binding polysaccharide. These findings suggest that the modified bacterial polysaccharide interacts with AT and promotes its anticoagulant action in a manner similar to that of heparin.
A Probabilistic Model of Melodic Similarity (2018)

Melodic similarity is an important concept for music databases, musicological studies, and interactive music systems. Dynamic programming is commonly used to compare melodies, often with a distance function based on pitch differences measured in semitones. This approach computes an “edit distance” as a measure of melodic dissimilarity. The problem can also be viewed in probabilistic terms: What is the probability that a melody is a “mutation” of another melody, given a table of mutation probabilities? We explain this approach and demonstrate how it can be used to search a database of melodies. Our experiments show that the probabilistic model performs better than a typical “edit distance” comparison.
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? (2008)

The incidence of obesity and non-esterified (‘free’) fatty acid-associated metabolic disorders such as the metabolic syndrome and diabetes is increasing dramatically in most countries. Although the pathogenesis of these metabolic disorders is complex, there is emerging evidence that ROS (reactive oxygen species) are critically involved in the aberrant signalling and tissue damage observed in this context. Indeed, it is now widely accepted that ROS not only play an important role in physiology, but also contribute to cell and tissue dysfunction. Inappropriate ROS generation may contribute to tissue dysfunction in two ways: (i) dysregulation of redox-sensitive signalling pathways, and (ii) oxidative damage to biological structures (DNA, proteins, lipids, etc.). An important source of ROS is the NOX family of NADPH oxidases. Several NOX isoforms are expressed in the liver and pancreatic β-cells. There is now evidence that inappropriate activation of NOX enzymes may damage the liver and pancreatic β-cells. In the context of the metabolic syndrome, the emerging epidemic of non-alcoholic steatohepatitis is thought to be NOX/ROS-dependent and of particular medical relevance. NOX/ROS-dependent β-cell damage is thought to be involved in glucolipotoxicity and thereby leads to progression from the metabolic syndrome to Type 2 diabetes. Thus understanding the role of NOX enzymes in liver and β-cell damage should lead to an increased understanding of pathomechanisms in the metabolic syndrome and diabetes and may identify useful targets for novel therapeutic strategies.
Increasing the Solubility of Inert Peripherally Aromatic POSS (2010)

Abstract : New POSS compounds with high temperature capability and good solubility in various organic solvents have been developed. By placing a single polycyclic aromatic group (naphthyl, phenanthryl, or pyrenyl) on a corner (via a corner-capping reaction) of (phenyl)7Si7O9(OH)3, cage symmetry is disrupted, which significantly increases solubility over (phenyl)8Si8O12. Thermal characteristics are retained, which makes these materials suitable for use in high performance polymers. Reasonable yields (29- 95%) were obtained for the reactions.
Object shape and reflectance modeling from observation (1997)

An object model for computer graphics applications should contain two aspects of information: shape and reflectance properties of the object. A number of techniques have been developed for modeling object shapes by observing real objects. In contrast, attempts to model reflectance properties of real objects have been rather limited. In most cases, modeled reflectance properties are too simple or too complicated to be used for synthesizing realistic images of the object.
Sutureless Amniotic Membrane ProKera for Ocular Surface Disorders (2013)

ProKera treatment is easy to use and reasonably well tolerated, with moderate success in corneal ulcers and encouraging results in acute moderate chemical injury. Recurrence of primary pathologic condition is seen particularly associated with neurotrophic keratitis and dry eye syndrome.
Pharmacotherapy for Alcohol Dependence: Anticraving Medications for Relapse Prevention (2006)

Alcohol dependence is a chronic disorder that results from a variety of genetic, psychosocial, and environmental factors. Relapse prevention for alcohol dependence has traditionally involved psychosocial and psychotherapeutic interventions. Pharmacotherapy, however, in conjunction with behavioral therapy, is generating interest as another modality to prevent relapse and enhance abstinence. Naltrexone and acamprosate are at the forefront of the currently available pharmacological options. Naltrexone is an opioid receptor antagonist and is thought to reduce the rewarding effect of alcohol. Acamprosate normalizes the dysregulation of N-methyl-D- aspartate (NMDA)-mediated glutamatergic excitation that occurs in alcohol withdrawal and early abstinence. These different mechanisms of action and different target neurotransmitter systems may endow the two drugs with efficacy for different aspects of alcohol use behavior. Since not all patients seem to benefit from naltrexone and acamprosate, there are ongoing efforts to improve the treatment outcomes by examining the advantages of combined pharmacotherapy and exploring the variables that might predict the response of the medications. In addition, novel medications are being investigated to assess their efficacy in preventing relapse and increasing abstinence.
A review of breast tomosynthesis. Part I. The image acquisition process (2013)

Mammography is a very well-established imaging modality for the early detection and diagnosis of breast cancer. However, since the introduction of digital imaging to the realm of radiology, more advanced, and especially tomographic imaging methods have been made possible. One of these methods, breast tomosynthesis, has finally been introduced to the clinic for routine everyday use, with potential to in the future replace mammography for screening for breast cancer. In this two part paper, the extensive research performed during the development of breast tomosynthesis is reviewed, with a focus on the research addressing the medical physics aspects of this imaging modality. This first paper will review the research performed on the issues relevant to the image acquisition process, including system design, optimization of geometry and technique, x-ray scatter, and radiation dose. The companion to this paper will review all other aspects of breast tomosynthesis imaging, including the reconstruction process.
CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites. (1988)

In recent malaria sporozoite vaccine trials in humans and mice, antibodies to the sporozoite coat protein have given only modest protection against sporozoite challenge. In contrast, irradiated sporozoites can protect mice against massive sporozoite infections. Evidence suggests that immunity in these mice is mediated by T cells. To identify the mechanism of immunity, we used monoclonal antibodies specific for either the CD4 or CD8 molecule to selectively deplete sporozoite-immunized mice of T-cell subsets. Though in vivo depletion of CD4+ T cells did not reduce immunity, depletion of CD8+ T cells abolished protection. Monoclonal antibody treatment did not affect anti-sporozoite antibody levels. Our data indicate that cytotoxic T cells are critical for immunity to large numbers of sporozoites and suggest that vaccine development should be reoriented toward stimulating cellular as well as humoral immunity.
Modern methods for the determination of polar motion and UT1 (1978)

The applications and Doppler satellite observations, laser ranging to artificial satellites and the Moon, and astronomic radio interferometry to monitoring polar motion and Universal Time System 1 (UT1) are discussed. How and what each method is capable of measuring, fundamental limitations, and the present status of the developments of each method were reviewed. Evaluations of the various methods as candidates for the next generation international polar motion and UT1 monitoring service are summarized.
A static analyzer for finding dynamic programming errors (2000)

There are important classes of programming errors that are hard to diagnose, both manually and automatically, because they involve a program's dynamic behavior. This article describes a compile-time analyzer that detects these dynamic errors in large, real-world programs. The analyzer traces execution paths through the source code, modeling memory and reporting inconsistencies. In addition to avoiding false paths through the program, this approach provides valuable contextual information to the programmer who needs to understand and repair the defects. Automatically-created models, abstracting the behavior of individual functions, allow inter-procedural defects to be detected efficiently. A product built on these techniques has been used effectively on several large commercial programs. Copyright © 2000 John Wiley & Sons, Ltd.
The barber pole, a linear magnetoresistive head (1975)

A short review of bias methods for the magnetoresistive head (MRH), all based on the rotation of the magnetization, is given, and the properties of the various methods are discussed. A novel bias method is proposed which avoids many disadvantages of the former since it is based on the rotation of the current with the aid of slanted conductors, covering the MRH. Measured and calculated static curves are given for this new configuration, for which the name "Barber Pole" is proposed. The Barber Pole turns out to be more linear than a field-biassed MRH. The wavelength response of a Barber Pole is calculated and found to be very similar to that of a normal MRH; this is confirmed by measurements. A two terminal track sensing head, based on the new biassing principle is described.
Synthetic and mechanistic investigations of the reductive electrochemical polymerization of vinyl-containing complexes of iron(II), ruthenium(II), and osmium(II) (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic and mechanistic investigations of the reductive electrochemical polymerization of vinyl-containing complexes of iron(II), ruthenium(II), and osmium(II)Jeffrey M. Calvert, Russell H. Schmehl, B. Patrick Sullivan, John S. Facci, Thomas J. Meyer, and Royce W. MurrayCite this: Inorg. Chem. 1983, 22, 15, 2151–2162Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/ic00157a013https://doi.org/10.1021/ic00157a013research-articleACS PublicationsRequest reuse permissionsArticle Views1373Altmetric-Citations122LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The hmu locus of Yersinia pestis is essential for utilization of free haemin and haem‐protein complexes as iron sources (1996)

Yersinia pestis strains utilize haem and several haem-protein complexes as sole sources of iron. In this study, the haemin uptake locus (hmu) of Y. pestis KIM6+ was selected from a genomic library by transduction into an Escherichia coli siderophore synthesis (entC) mutant. Recombinant plasmids containing a common 16 kb BamHI insert were isolated that allowed E. coli entC to use haemin as an iron source. An 8.6 kb region of this insert was found to be essential for haemin utilization and encoded at least five proteins with molecular masses of 79/77, 44, 37, 35, and 30/27.5 kDa. A 10.9 kb Clal fragment containing the hmu locus showed varying degrees of homology to genomic DNA from Yersinia pseudotuberculosis, Yersinia enterocolitica, and other genera of Enterobacteriaceae. An E. coli hemA aroB strain harbouring cloned hmu genes used haemin as both an iron and porphyrin source but only on iron-poor medium, suggesting that haemin uptake is tightly iron regulated. Additionally, haemoglobin and myoglobin were used as iron sources by an E. coli entC (pHMU2.2) strain. Deletion of the hmu locus from Y. pestis KIM6+ chromosome generated a mutant that grew poorly on iron-depleted medium containing free haemin as well as mammalian haem-protein complexes including haemoglobin, haemoglobin-haptoglobin, myoglobin, haem-haemopexin, and haem-albumin unless it was complemented with cloned hmu genes.