gebhart/patrepeval huggingface dataset:
Equipment for local hyperthermia therapy of cancer. (1983)

Technology for local heat therapy of cancer is evolving rapidly at a number of technologically diverse and geographically scattered institutions and companies. No single technology is superior to others in all applications, and no single company, laboratory, or research group has all the answers. An ideal system would provide focused heating at depth in a predictable fashion, with little probability of generating undesired hot spots in normal tissues and little interference with monitoring equipment. Existing systems approximate this ideal to different degrees, depending on the anatomy and geometry of the tumor and its surrounding tissues. In the foregoing discussion the important problem of measuring temperatures in tumors and normal tissues has been slighted. At the present time, all thermometry is necessarily invasive, and there are limitations to the number of points at which temperatures can be measured utilizing percutaneously placed catheters as conduits for thermometers. However, further advances in the art, the science, and the technology of local heat therapy are likely to be forthcoming in the next few years from a diverse community of investigators and young companies who are following an interesting variety of approaches. Continued research and development in the spirit of constructive, rather than destructive, competition will certainly advance the field substantially--much to the benefit of patients. At present, however, clinical engineers should realize that hyperthermia therapy for cancer is still experimental. Despite the flurry of commercial activity, considerable caution should be exercised in the purchase and use of hyperthermia equipment.
On-line discovery of flock patterns in spatio-temporal data (2009)

With the recent advancements and wide usage of location detection devices, large quantities of data are collected by GPS and cellular technologies in the form of trajectories. While most previous work on trajectory-based queries has concentrated on traditional range, nearest-neighbor and similarity queries, there is an increasing interest in queries that capture the "aggregate" behavior of trajectories as groups. Consider, for example, finding groups of moving objects that move "together", i.e. within a predefined distance to each other, for a certain continuous period of time. Such queries typically arise in surveillance applications, e.g. identify groups of suspicious people, convoys of vehicles, flocks of animals, etc. In this paper we first show that the on-line flock discovery problem is polynomial and then propose a framework and several strategies to discover such patterns in streaming spatio-temporal data. Experiments with real and synthetic trajectorial datasets show that the proposed algorithms are efficient and scalable.
Synthesis of direct-coupled-resonators bandpass filters for WDM systems (2002)

A simple technique for the exact synthesis of selective bandpass filters for wavelength division multiplexing (WDM) systems is presented. The filters consist of direct-coupled ring resonators or cascaded Bragg gratings. The proposed technique permits the calculation of the physical dimensions of the optical structures given the desired frequency response of the filter in terms of bandwidth, free spectral range, out-of-band rejection, and frequency characteristic. The technique, explained in detail for Butterworth and Chebyshev frequency responses, is exact, uses closed-form formulae, and is physically well based. The resulting devices are very compact, have a high out-of-band attenuation, and are suitable for high-density integrated optics. Several filters for applications such as channel add-drop, channel selection, demultiplexing, multichannel filtering, and interleavers are designed, analyzed, and discussed in the paper.
Cell-cell adhesion molecules (1991)

Conference Article| November 01 1991 Cell-cell adhesion molecules Elisabeth Bock Elisabeth Bock 1The Protein Laboratory, University of Copenhagen, Panum Institute, 3C Blegdamsuej, DK-2200 Copenhagen N, Denmark Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (4): 1076–1080. https://doi.org/10.1042/bst0191076 Article history Received: June 07 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Elisabeth Bock; Cell-cell adhesion molecules. Biochem Soc Trans 1 November 1991; 19 (4): 1076–1080. doi: https://doi.org/10.1042/bst0191076 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: CAM, cell adhesion molecule, EGF, epidermal growth factor This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
IN VITRO AND IN VIVO PROTECTION AGAINST PHOTOTOXIC SIDE EFFECTS OF PHOTODYNAMIC THERAPY BY RADIOPROTECTIVE AGENTSWR–2721 ANDWR–77913 (1988)

Abstract— The experimental radioprotective agentsS–2‐(3‐aminopropylamino) ethyl phosphorothioate(WR–2721) and 3‐amino‐2‐hydroxypropyl phosphorothioate(WR–77913) are also protective against photosensitized oxidation. They reduce porphyrin‐induced photopolymerization of lens cytosol proteins in vitro, and phototoxic damage to mouse skin in vivo. The phototoxic dose modification factor (DMF) was 1.5 which is similar to that found in ionizing radiation. Part of the mechanism by which sulfhydryls afford this protection is by accelerating photobleaching of the porphyrins.
Diastolic Heart Failure (2004)

A 78-year-old woman with a history of hypertension is admitted to the hospital with congestive heart failure. Physical examination reveals a blood pressure of 180/90 mm Hg, increased jugular venous pressure, peripheral edema, and pulmonary rales. A chest radiograph shows pulmonary edema and mild cardiomegaly. An echocardiogram shows a left ventricular ejection fraction of 70 percent. The left ventricular Doppler filling pattern is abnormal and consistent with an elevated pulmonary-capillary wedge pressure. How should this patient be treated?
Pose Guided Person Image Generation (2017)

This paper proposes the novel Pose Guided Person Generation Network (PG$^2$) that allows to synthesize person images in arbitrary poses, based on an image of that person and a novel pose. Our generation framework PG$^2$ utilizes the pose information explicitly and consists of two key stages: pose integration and image refinement. In the first stage the condition image and the target pose are fed into a U-Net-like network to generate an initial but coarse image of the person with the target pose. The second stage then refines the initial and blurry result by training a U-Net-like generator in an adversarial way. Extensive experimental results on both 128$\times$64 re-identification images and 256$\times$256 fashion photos show that our model generates high-quality person images with convincing details.
Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae (2011)

Microalgae have presented themselves as a strong candidate to replace diminishing oil reserves as a source of lipids for biofuels. Here we describe successful modifications of terrestrial plant lipid content which increase overall lipid production or shift the balance of lipid production towards lipid varieties more useful for biofuel production. Our discussion ranges from the biosynthetic pathways and rate limiting steps of triacylglycerol formation to enzymes required for the formation of triacylglycerol containing exotic lipids. Secondarily, we discuss techniques for genetic engineering and modification of various microalgae which can be combined with insights gained from research in higher plants to aid in the creation of production strains of microalgae.
Genomics and proteomics in transplantation (2005)

Purpose of review Expression profiling of genes and proteins using a growing number of high-throughput technologies has facilitated developing a global view of biologic systems in health and disease. These technologies have now taken a center stage in the process of gene discovery and are contributing to advances in our understanding of gene and protein functionality. These tools also provide a robust and efficient way of looking at how multiple genes and proteins interact in functional networks, although we look forward to more progress in this area. Data from DNA microarrays and proteomics can also be used to identify candidate genes as potential diagnostic, prognostic, or therapeutic markers. In fact, it is likely that the first clinical applications of these genomic technologies will be in diagnostics, and we see this happening now, becoming common in the next few years. Recent findings In kidney transplantation, these techniques are accelerating the search for the mechanisms of immune-mediated acute rejection and the kidney injury, fibrosis, and tubular atrophy of chronic allograft nephropathy. Studies in liver transplantation have focused on mechanisms of liver injury from hepatitis and the pathogenesis of hepatocellular carcinoma. In heart and lung transplantation, the focus has been on the progression of coronary artery disease and bronchiolitis obliterans, respectively. Thus, each field of transplantation has taken advantage of these emerging technologies. Summary Rapid improvements in computational methods are helping to deal with the vast amount of sequence and other data these genomic and proteomic tools generate, creating new opportunities to apply genomics and proteomics to clinical medicine.
Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase. (1983)

Tryptase, the dominant neutral protease of human pulmonary mast cell secretory granules, has the capacity in vitro to generate C3a anaphylatoxin from purified human C3. Only the alpha-chain of C3 is cleaved, and major fragments with apparent m.w. of 105,000, 39,500, 34,000, 29,000, and 9000 are detected by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under reducing conditions. Fragments of 34,000 and 9000 m.w. are detected without reduction. A portion of the 9000 m.w. protein corresponds to C3a by virtue of its co-migration in SDS polyacrylamide gels with purified C3a and with trypsin-generated C3a, by its detection in a radioimmunoassay for C3a, and by its contractile activity on the guinea pig ileum bioassay. In the presence of heparin, another component of the mast cell secretory granule, the rate of appearance and the distribution of C3 cleavage fragments as assessed in SDS polyacrylamide gels are not appreciably changed with the exception that no C3a material can be detected in the SDS polyacrylamide gels or by radioimmunoassay and bioassay of the unresolved reaction mixture. Enhanced catabolism of authentic C3a by tryptase occurs in the presence of heparin and by analogy when C3a is generated from C3 by tryptase in the presence of heparin. Whereas tryptase secreted by activated human mast cells may generate C3a, a potentially important additional mediator of immediate hypersensitivity events, the concomitant release of heparin may serve to down-regulate C3a irrespective of its mechanism of generation.
Hog cholera virus: molecular composition of virions from a pestivirus (1991)

Virions from hog cholera virus (HCV), a member of the genus Pestivirus, were analyzed by using specific antibodies. The nucleocapsid protein was found to be a 14-kDa molecule (HCV p14). An equivalent protein could also be demonstrated for virions from another pestivirus, bovine viral diarrhea virus. The HCV envelope is composed of three glycoproteins, HCV gp44/48, gp33, and gp55. All three exist in the form of disulfide-linked dimers in virus-infected cells and in virions; HCV gp44/48 and gp55 each form homodimers, whereas gp55 is also found dimerized with gp33. Such complex covalent interactions between structural glycoproteins have not been described so far for any RNA virus.
Fibrin based drug delivery systems. (1991)

Fibrinogen is the natural substrate for thrombin, the final proteolytic enzyme of the blood coagulation cascade. Following reaction with thrombin, fibrinogen is converted into fibrin monomers which then spontaneously polymerize into fibrin threads forming the fibrin matrix. This biochemical reaction between fibrinogen and thrombin has been used to produce natural, biodegradable, biocompatible systems for sustained drug delivery. Three potential delivery systems have been explored: 1) fibrin microparticles with drug entrapped are produced by an emulsion process, 2) reaction between fibrinogen adsorbed on suspended drug and thrombin in solution results in the formation of fibrin-coated drug particulates, and 3) fibrin sheets suitable as implants have been cast with drug entrapped. The drug release behavior of both small and large molecular weight substances from these systems was evaluated.
The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. (1989)

We measured the human pim-1 protooncogene (PIM) expression during fetal development and in hematopoietic malignancies. Our data indicate that during human fetal hematopoiesis the 33-kDa pim product, p33pim, is highly expressed in the liver and spleen. In contrast, at the adult stage it is only slightly expressed in circulating granulocytes. Out of 70 hematopoietic malignancies analyzed, 51 patients and 19 cell lines, p33pim was overexpressed in approximately 30% of the samples, particularly in myeloid and lymphoid acute leukemias. This overexpression was unrelated to any stage of cellular differentiation and was not due to gene rearrangement or amplification. These results imply a physiological role of the pim-1 protooncogene during hematopoietic development and a deregulation in various leukemias.
The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments (1999)

We reported recently on the intracellular localisation of the hyaluronan receptor RHAMM/IHABP in human cancer cells. Here we describe the colocalisation of RHAMM/IHABP proteins with microtubules, both in interphase and dividing cells, suggesting that RHAMM/IHABP represents a novel member of the family of microtubule-associated proteins (MAPs). We have identified four different splice variants of RHAMM/IHABP, all of which colocalise, at least transiently, with microtubules when expressed as GFP fusion proteins in HeLa cells. Using microtubule-binding assays and transient transfection experiments of deletion-bearing RHAMM/IHABP mutants, we localised the microtubule-binding region to the extreme N terminus of RHAMM/IHABP. This interaction domain is composed of two distinct subdomains, one of which is sufficient to mediate binding to the mitotic spindle while both domains are required for binding of RHAMM/IHABP proteins to interphase microtubules. Sequence analysis revealed that the projection domain of RHAMM/IHABP is predicted to form coiled-coils, implying that RHAMM/IHABP represents a filamentous protein capable of interacting with other proteins and we found that RHAMM/IHABP interacts with actin filaments in vivo and in vitro. Moreover, in vitro translated RHAMM/IHABP isoforms efficiently bind to immobilised calmodulin in a Ca(2+)-dependent manner via a calmodulin-binding site within the projection domain of RHAMM/IHABP (residues 574-602). Taken together, our results strongly suggest that RHAMM/IHABP is a ubiquitously expressed, filamentous protein capable of interacting with microtubules and microfilaments and not, as numerous previous reports suggest, a cell surface receptor for the extracellular matrix component hyaluronan.
Involvement of Notch signaling in hippocampal synaptic plasticity (2004)

During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null mice die during embryonic development, it has proven difficult to determine the functions of Notch. Here, we used Notch antisense transgenic mice that develop and reproduce normally, but exhibit reduced levels of Notch, to demonstrate a role for Notch signaling in synaptic plasticity. Mice with reduced Notch levels exhibit impaired long-term potentiation (LTP) at hippocampal CA1 synapses. A Notch ligand enhances LTP in normal mice and corrects the defect in LTP in Notch antisense transgenic mice. Levels of basal and stimulation-induced NF-kappa B activity were significantly decreased in mice with reduced Notch levels. These findings suggest an important role for Notch signaling in a form of synaptic plasticity known to be associated with learning and memory processes.
A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth. (1988)

A novel ganglioside, de-N-acetyl-GM3 (neuraminyllactosylceramide, II3NeuNH2LacCer), was found in the monosialoganglioside fraction of A431 cells and B16 melanoma cells by high-performance liquid chromatography, thin-layer chromatography, and immunoblotting with its specific monoclonal antibody DH5. This novel type of membrane ganglioside strongly enhanced the kinase activity associated with the epidermal growth factor (EGF) receptor, and it showed 32, 35, and 12% growth stimulation as compared with control cultures of A431, Swiss 3T3, and B16 melanoma cells, respectively. Exogenously added de-N-acetyl-GM3 did not alter the affinity of EGF binding to its receptor. These properties of de-N-acetyl-GM3 are in striking contrast to those of GM3 and its lyso derivative (lyso-GM3) which were previously shown to inhibit EGF receptor kinase activity and to inhibit growth in the same cells. These data indicate that de-N-acetylation at the sialic acid moiety of GM3 ganglioside is an important mechanism for modulation of EGF-dependent cell growth. The mechanism is antagonistic to that of GM3-dependent modulation of receptor function.
The 1.6-kV AlGaN/GaN HFETs (2006)

The breakdown voltages in unpassivated nonfield-plated AlGaN/GaN HFETs on sapphire substrates were studied. These studies reveal that the breakdown is limited by the surface flashover rather than by the AlGaN/GaN channel. After elimination of the surface flashover in air, the breakdown voltage scaled linearly with the gate-drain spacing reaching 1.6 kV at 20 mum. The corresponding static ON-resistance was as low as 3.4 mOmegamiddotcm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This translates to a power device figure-of-merit V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BR</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">ON</sub> =7.5times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> V <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> middotOmega <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> , which, to date, is among the best reported values for an AlGaN/GaN HFET
Synthesis and Properties of Sulfonated EPDM (1980)

Metal sulfonate groups were introduced into an ethylene-propylene-diene monomer terpolymer (EPDM) via reaction of its residual unsaturation with acetyl sulfate, followed by neutralization of the resultant polymeric sulfonic acid with ometal acetates. The composition, structure, and molecular weight of the EPDM and the sulfonate content, cation borne by the sulfonate group, and metal acetate concentration of the ionomer were found to substantially affect the rheological and mechanical properties of the ionomer. Through the proper selection of EPDM backbone, EPDM molecular weight, and sulfonate content, and through the use of the zinc cation, it was possible to prepare EPDM-based ionomers with excellent mechanical properties and with the lowest possible melt viscosities. Although formulations derived from these zinc sulfonate-containing EPDM's possess melt viscosities that are higher than desirable for facile processability, in many respects they are truly thermoplastic elastomers.
Endogenous and Exogenous Vasopressin during Hemodialysis (2009)

Intradialytic hypotension likely results from hypovolemia as well as patient and dialysis-specific factors. An impaired vasoconstrictive response to volume loss during hemodialysis has been demonstrated and increasing evidence suggests that deficiency in the hormone arginine vasopressin may be a contributing factor. Although vasopressin is widely recognized for its role in the regulation of serum osmolality, vasopressin is also an important regulator of blood pressure in health and in various disease states. That vasopressin deficiency contributes to the pathogenesis of intradialytic hypotension is suggested by several observations. First, vasopressin levels typically fall during hemodialysis when a rise might be expected as a result of volume loss. Second, therapies that prevent a fall in osmolality during dialysis, including dialysis against a high sodium bath and isolated ultrafiltration, have been shown to improve intradialytic blood pressure stability. Finally, and perhaps most importantly, the administration of low-dose exogenous vasopressin during dialysis has been shown to support blood pressure and improve volume removal. Further research is needed to determine the effect of chronic vasopressin (or selective V1a agonist) administration during dialysis on volume removal, inter- and intradialytic blood pressure control, and, ultimately, clinical outcomes in end-stage renal disease patients on dialysis.
Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers. (1990)

The authors investigated the mechanism of action of the antidepressant serotonin (5-HT) reuptake blocker citalopram in the rat by means of an in vivo electrophysiologic paradigm. In control animals, the acute intravenous administration of citalopram reduced the firing rate of dorsal raphe nucleus serotonergic neurons with an ED50 of 230 micrograms/kg. Rats were treated with citalopram (20 mg/kg/day i.p.) for 2, 7, and 14 days. Two-day treatment was accompanied by a marked reduction of the firing activity of serotonergic neurons; there was a partial recovery after 7 days of treatment, and a complete one following 14-day citalopram administration. The response of serotonergic neurons to intravenously administered lysergic acid diethylamide (LSD), a somatodendritic 5-HT autoreceptor agonist, was reduced in rats treated with citalopram for 14 days, suggesting that such a treatment reduces the sensitivity of the somatodendritic autoreceptor. Fourteen-day citalopram treatment also markedly enhanced the efficacy of the stimulation of the afferent serotonergic pathway in suppressing the firing activity of postsynaptic CA3 dorsal hippocampus pyramidal neurons. This enhanced efficacy of serotonergic synaptic transmission was not the result of an increased sensitivity of postsynaptic neurons to serotonin, as the effect of the direct microiontophoretic application of serotonin onto these same neurons was not modified. That serotonin reuptake blockade per se was responsible for this enhancement could also be ruled out, as the acute intravenous administration of citalopram (1 mg/kg) in control rats failed to enhance the efficacy of the stimulation. To determine an involvement of the 5-HT terminal autoreceptor, methiothepin (1 mg/kg), a terminal autoreceptor antagonist, was injected intravenously in control and citalopram-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)