gebhart/patrepeval huggingface dataset:
Field shrinkage curves of a swelling clay soil: analysis of multiple structural swelling and shrinkage phases in the prisms of a Vertisol (2001)

The variations in the layer thickness of a Vertisol cropped with sugarcane were recorded under natural conditions for several months. Drainage pipes were installed at 1.10 m depth to drain water quickly from macro-cracks. The soil gravimetric water content was measured from the surface to 1.10 m depth at weekly intervals. The relation between soil water content and soil bulk specific volume (shrinkage curve) is not unique. A significant structural swelling or shrinkage can occur at any water content of the clay matrix while the macro-cracks remain air-filled. The variations in structural water content account for &amp;gt;60% and 80% of the total water content variations, respectively, in topsoil and subsoil. In the latter, the intra-prism structural porosity is filled and then emptied prior to matric porosity. This explains the disappearance of the water stress in such dry soil after any rainfall event. A more detailed description of the intra-prism structural porosity is required for a better understanding of the processes. Our work suggests that this porosity is mainly formed by planar inter-aggregate voids in the tilled layers, whereas its shape is tubular in the deeper layers. The results already provide guidelines concerning the modelling of water flow in such Vertisol, i.e. water flow in structural pores is quite independent of matric and crack flows.
Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. (1995)

In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, promoting its degradation and abrogating wild-type p53 function. AG1521 cells transfected with either E6 or E6/E7 showed no radiation induction of either p53 or WAF1/Cip1. The radioresistance of these cells were significantly increased; the D0 of the survival curves rose from 130 +/- 4 cGy for wild type (neo-transfected) cells to 178-192 cGy for three subclones transfected with E6 alone, and 151-218 cGy for eight subclones transfected with E6/E7. The change in radiosensitivity took place before the process of cellular immortalization and transformation produced by transfection with these genes. Thus, the effect on radiosensitivity appears to be an early effect of the loss of p53 function in non-transformed cells, perhaps related to the loss of the G1 checkpoint and of the capacity for programmed death amongst radiation damaged cells.
A role for NF-κB–dependent gene transactivation in sunburn (2000)

Exposure of skin to ultraviolet (UV) radiation is known to induce NF-kappaB activation, but the functional role for this pathway in UV-induced cutaneous inflammation remains uncertain. In this study, we examined whether experimentally induced sunburn reactions in mice could be prevented by blocking UV-induced, NF-kappaB-dependent gene transactivation with oligodeoxynucleotides (ODNs) containing the NF-kappaB cis element (NF-kappaB decoy ODNs). UV-induced secretion of IL-1, IL-6, TNF-alpha, and VEGF by skin-derived cell lines was inhibited by the decoy ODNs, but not by the scrambled control ODNs. Systemic or local injection of NF-kappaB decoy ODNs also inhibited cutaneous swelling responses to UV irradiation. Moreover, local UV-induced inflammatory changes (swelling, leukocyte infiltration, epidermal hyperplasia, and accumulation of proinflammatory cytokines) were all inhibited specifically by topically applied decoy ODNs. Importantly, these ODNs had no effect on alternative types of cutaneous inflammation caused by irritant or allergic chemicals. These results indicate that sunburn reactions culminate from inflammatory events that are triggered by UV-activated transcription of NF-kappaB target genes, rather than from nonspecific changes associated with tissue damage.
A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes (2014)

Our meta-analysis suggests that single administrations ketamine are efficacious in the rapid treatment of unipolar and bipolar depression. Additional research is required to determine optimal dosing schedules, route, treatment schedules, and the potential efficacy of other glutamatergic agents.
Global Cancer in Women: Burden and Trends (2017)

<i>This review is an abbreviated version of a report prepared for the American Cancer Society Global Health department and EMD Serono, Inc., a subsidiary of Merck KGaA, Darmstadt, Germany, which was released at the Union for International Cancer Control World Cancer Congress in Paris in November 2016. The original report can be found at https://www.cancer.org/health-care-professionals/our-global-health-work/global-cancer-burden/global-burden-of-cancer-in-women.html. Staff in the Intramural Research Department of the American Cancer Society designed and conducted the study, including analysis, interpretation, and presentation of the review. The funding sources had no involvement in the study design, data analysis and interpretation, or preparation of the review</i>There are striking disparities in the global cancer burden in women, yet few publications highlight cancer occurrence in this population, particularly for cancers that are not sex specific. This article, the first in a series of two, summarizes the current burden, trends, risk factors, prevention, early detection, and survivorship of all cancers combined and seven sites (breast, cervix, uterine corpus, ovary, colorectum, lung, and liver) that account for about 60% of the cancer burden among women worldwide, using data from the International Agency for Research on Cancer. Estimated 2012 overall cancer death rates in general are higher among women in low- and middle-income countries (LMICs) than high-income countries (HICs), despite their lower overall incidence rates, largely due to inadequate access to early detection and treatment. For example, the top mortality rates are in Zimbabwe (147 deaths per 100,000) and Malawi (138). Furthermore, incidence rates of cancers associated with economic development (e.g., lung, breast, colorectum) are rising in several LMICs. The burden of cancer among women could be substantially reduced in both HICs and LMICs through broad and equitable implementation of effective interventions, including tobacco control, HPV and HBV vaccination, and screening (breast, cervix, and colorectum). <i>Cancer Epidemiol Biomarkers Prev; 26(4); 444-57. ©2017 AACR</i><b>See related article by Islami et al. in this <i>CEBP Focus</i> section, "Global Cancer in Women."</b>
Neuroprotective effect of ONO-1078, a leukotriene receptor antagonist, on focal cerebral ischemia in rats. (2002)

ONO-1078 has the protective effect on focal cerebral ischemia in rats, which is partially attributed to the inhibition of brain edema. This may represent a novel approach to the treatment of acute cerebral ischemia with cysteinyl leukotriene receptor antagonists.
Laser plasma source of amorphic diamond (1989)

Amorphic diamond films characterized by a high percentage of sp3 bonds have been prepared in an UHV environment with a laser plasma source of carbon ions. Peak power densities in excess of 1011 W/cm2 were found necessary to produce films at growth rates of 0.5 μm/h over areas of 20 cm2 having optical quality sufficient to show bright interference colors.
A fully differential CMOS line driver for ISDN (1990)

A CMOS differential buffer amplifier for ISDN applications is discussed. The chip operates from a single 5-V power supply and can deliver a 6-V (peak-to-peak), 80 kHz signal into a load of 100 Omega and/or 300 pF with a total harmonic distortion (THD) of about 0.25%. The amplifier's main feature is its power supply rejection ratio, which remains practically constant at -75 dB from DC to several hundred kilohertz for both positive and negative supplies with the common-mode voltage generated on chip. In an inverting configuration with a gain of 1.5, the 1% setting time for step input is less than 500 ns for a step of 1.5 V and less than 1 mu s for a step of 6 V (for both cases, the output load is 100 Omega and 300 pF). By using relatively small devices for the output stage, the amplifier occupies an area of only 1400 mil/sup 2/ in a 2- mu m double-poly single-metal n-well CMOS technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Vision-Based Indoor Scene Analysis for Natural Landmark Detection (2006)

In this paper a vision-based landmark extractor for goal-oriented navigation of a mobile robot is proposed. An indoor space scene analysis allows to detect natural structures relevant for navigation like doors or the floor in monocular images of the environment. The detection is based on a priori knowledge of the shape and functionality of searched structures. This algorithm works in real-time and is stable against variation of illumination. The approach is applicable for indoor environments which have clear line structures and large homogenous colour surfaces. The core of this method combines region based as well as edge based elements. The segmentation begins with an orientation selective Hough-Transform (OHT) including line segment detection and generates a reticule of convex polygons. Homogeneous colour similar polygons are segmented and merged by an region growing process. Finally a feature extraction and identification is performed to assign regions to known objects.
Identification of a missense mutation in one allele of a patient with Pompe disease, and use of endonuclease digestion of PCR-amplified RNA to demonstrate lack of mRNA expression from the second allele. (1991)

Infantile-onset glycogen storage disease type II, or Pompe disease, results from a genetic deficiency of the lysosomal enzyme acid alpha glucosidase (GAA). Sequencing of the cDNA from a cell line (GM 244) derived from a patient with Pompe disease demonstrated a T953-to-C transition that predicted a methionine-to-threonine substitution at codon 318. The basepair substitution resulted in loss of restriction-endonuclease sites for NcoI and StyI. Analysis of genomic DNA revealed both a normal and an abnormal NcoI fragment, indicating that the patient was a genetic compound. NcoI and StyI digestion of cDNA, amplified by PCR from reverse-transcribed RNA, demonstrated that greater than 95% of the GAA mRNA in GM 244 was derived from the allele carrying the missense mutation. The missense mutation was uncommon, since it was not detected in 37 additional GAA-deficient chromosomes, as determined by digestion of genomic DNA with NcoI and hybridization. The amino acid substitution predicts a new potential site for N-linked glycosylation, as well as major changes in secondary structure of the protein. We could confirm that the mutation was responsible for the enzyme deficiency by demonstrating that a hybrid minigene containing the mutation did not express GAA enzyme activity after transient gene expression. We have therefore now provided the first identification of a single-basepair missense mutation in a patient with Pompe disease and furthermore have demonstrated that the patient is a genetic compound with the second allele barely expressing mRNA.
Performance and Reliability of Multijunction III-V Modules for Concentrator Dish and Central Receiver Applications (2006)

Over the last 15 years, Solar Systems have developed a dense array receiver PV technology for 500X concentrator reflective dish applications. This concentrator PV technology has been successfully deployed at six different locations in Australia, counting for more than 1 MWp of installed peak power. A new Multijunction III-V receiver to replace the current silicon Point-Contact solar cells has recently been developed. The new receiver technology is based on high-efficiency (>32%) Concentrator Ultra Triple Junction (CUTJ) solar cells from Spectrolab, resulting in system power and energy performance improvement of more than 50% compared to the silicon cells. The 0.235 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> concentrator PV receiver, designed for continuous 500X operation, is composed of 64 dense array modules, and made of series and parallel-connected solar cells, totaling approximately 1,500 cells. The individual dense array modules have been tested under high intensity pulsed light, as well as with concentrated sunlight at the Solar Systems research facility and at the National Renewable Energy Laboratory's High Flux Solar Furnace. The efficiency of the dense array modules ranges from 30% to 36% at 500X (50 W/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , AM1.5D low AOD, 21C). The temperature coefficients for power, voltage and current, as well as the influence of Air Mass on the cell responsivity, were measured. The reliability of the dense array multijunction III-V modules has been studied with accelerated aging tests, such as thermal cycling, damp heat and high-temperature soak, and with real-life high-intensity exposure. The first 33 kWp multijunction III-V receiver was recently installed in a Solar Systems dish and tested in real-life 500X concentrated sunlight conditions. Receiver efficiencies of 30.3% and 29.0% were measured at Standard Operating Conditions and Normal Operating Conditions respectively
Targeted single molecule mutation detection with massively parallel sequencing (2015)

Next-generation sequencing (NGS) technologies have transformed genomic research and have the potential to revolutionize clinical medicine. However, the background error rates of sequencing instruments and limitations in targeted read coverage have precluded the detection of rare DNA sequence variants by NGS. Here we describe a method, termed CypherSeq, which combines double-stranded barcoding error correction and rolling circle amplification (RCA)-based target enrichment to vastly improve NGS-based rare variant detection. The CypherSeq methodology involves the ligation of sample DNA into circular vectors, which contain double-stranded barcodes for computational error correction and adapters for library preparation and sequencing. CypherSeq is capable of detecting rare mutations genome-wide as well as those within specific target genes via RCA-based enrichment. We demonstrate that CypherSeq is capable of correcting errors incurred during library preparation and sequencing to reproducibly detect mutations down to a frequency of 2.4 × 10(-7) per base pair, and report the frequency and spectra of spontaneous and ethyl methanesulfonate-induced mutations across the Saccharomyces cerevisiae genome.
Selective Modulation of CD4+ T Cells from Lupus Patients by a Promiscuous, Protective Peptide Analog (2005)

A peptide encompassing residues 131-151 of the spliceosomal U1-70K protein and its analog phosphorylated at Ser140 were synthesized as potential candidates for the treatment of patients with lupus. Studies in the MRL/lpr and (NZB x NZW)F1 lupus models have demonstrated that these sequences contain a CD4+ T cell epitope but administration of the phosphorylated peptide only ameliorates the clinical manifestations of treated MRL/lpr mice. Binding assays with soluble HLA class II molecules and molecular modeling experiments indicate that both peptides behave as promiscuous epitopes and bind to a large panel of human DR molecules. In contrast to normal T cells and T cells from non-lupus autoimmune patients, we found that PBMCs from 40% of lupus patients selected randomly and CFSE-labeled CD4+ T cells proliferate in response to peptide 131-151. Remarkably, however, we observed that phosphorylation of Ser140 prevents CD4+ T cells proliferation but not secretion of regulatory cytokines, suggesting a striking immunomodulatory effect of phosphorylated analog on lupus CD4+ T cells that was unique to patients. The analog might act as an activator of regulatory T cells or as a partial agonist of TCR.
The Differential Thermal Analysis of Perchlorates. VII. Catalytic Decompositions of the Alkali Metal Perchlorates by Manganese Dioxide (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Differential Thermal Analysis of Perchlorates. VII. Catalytic Decompositions of the Alkali Metal Perchlorates by Manganese DioxideMeyer M. Markowitz and Daniel A. BorytaCite this: J. Phys. Chem. 1965, 69, 4, 1114–1123Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/j100888a005https://doi.org/10.1021/j100888a005research-articleACS PublicationsRequest reuse permissionsArticle Views164Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Inhibition of heat shock protein synthesis by heat-inducible antisense RNA. (1986)

We show that antisense RNAs transcribed from genes that are stably integrated into the genome can be used to inhibit the expression of an endogenous cellular gene. Drosophila tissue culture cells were stably transformed with a gene encoding a heat-inducible RNA complementary to the message for hsp26, one of the small heat shock proteins. These cells produced much less hsp26 after heat shock than did untransformed cells. The inhibition was highly specific: expression of the closely related heat shock proteins hsp22, hsp23, and hsp28 was unaffected. By varying the copy number of the antisense gene, the degree of inhibition was varied over a broad range. Reducing the rate of hsp26 synthesis did not appear to affect the synthesis of any other protein during either heat shock or recovery.
Analysis of Interferon-α2 Sequences in Human Genomic DNA (1993)

We have analyzed the genomic DNA sequence corresponding to the human interferon-alpha 2 (IFN-alpha 2) gene locus. In human lymphoblastoid Namalwa cells, we have detected sequences corresponding to IFN-alpha 2b and -2c, while in human KG-1 cells both IFN-alpha 2a and -2b were present. However, in 100 independent IFN-alpha 2 clones derived from 20 unrelated Caucasian volunteers, we found only sequences corresponding to IFN-alpha 2b. Statistical analysis of this result suggests that the sequences corresponding to IFN-alpha 2a and -2c are either rare allelic variants of this gene, occurring in only a minority of the Caucasian population, or are restricted to transformed cell lines.
Dna-Coated Carbon Adsorbents Experimental Assessment and Results Op Severe Psoriasis Treatment (1992)

Newly developed combined adsorbents, containing from 1 to 8 mg of thymic DNA per 1 g of the granulated or the fibrous carbonic matrix, demonstrated good biocompatibility and selectivity for DNA- and DNP-binding substances. In a group of 14 patients with severe psoriasis (uncontrol trial) a single hemoperfusion procedure through DNA-coated granulated synthetic carbons (perfusion volume was 2.5-3.1 L, sorbent quantity was 30 g) resulted in complete remission in 6 patients and in substantial improvement of clinical status in 6 other patients. A positive effect was observed in 4 patients during 7-11 months; in 8 patients it is being observed for more than 29-33 months. The double-blind tests in the group of patients subjected to hemoperfusion through the DNA-coated charcoal (27 people) and uncoated charcoal (9 people) showed the full-scale remission in 55.5% and 11.2% respectively. The authors believe that the DNA-coated activated carbons can be an effective therapeutic procedure for treatment of numerous immuno-dependent diseases and states associated with disorders in the kinetics of cell division.
Efficient Copper-Catalyzed Benzylic Amidation with Anhydrous Chloramine-T (2007)

Benzylic hydrocarbons are selectively converted to the corresponding sulfonamides by the [Cu(CH(3)CN)(4)]PF(6)-catalyzed reaction with anhydrous TolSO(2)NNaCl (chloramine-T). Under the same conditions, representative ethers are also alpha-amidated; olefins produce allyl sulfonamides, aziridines, and/or beta-chloro sulfonamides.
DNA nanobiostructures (2001)

Recent advances in the field of nanotechnology and nanobiotechnology have been fuelled by the advancement in fabrication technologies that allow construction of artificial structures that are the same size or smaller than many biological entities.
Review of the impact of presbyopia on quality of life in the developing and developed world (2013)

This review suggests that the effect of presbyopia and its treatments on QoL remain poorly described and incompletely treated, especially in developing areas of the world.
Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase (1995)

The tyrosine kinase Tyk-2 is physically associated with the Type I interferon (IFN) receptor complex and is rapidly activated during IFN alpha stimulation. We report that Tyk-2 forms stable complexes with the SH2-containing hematopoietic cell phosphatase (HCP) in several hematopoietic cell lines in vivo, and that the IFN alpha-induced tyrosine-phosphorylated form of Tyk-2 is a substrate for the phosphatase activity of HCP in in vitro assays. Furthermore, treatment of cells with the phosphatase inhibitor sodium orthovanadate induces tyrosine phosphorylation of Tyk-2 and an associated 115-kDa protein. Altogether, these data suggest that HCP regulates tyrosine phosphorylation of the Tyk-2 kinase, and thus its function may be important in the transmission of signals generated at the Type I IFN receptor level.
Synthesis and catalytic properties of MIL-100(Fe), an iron(iii) carboxylate with large pores (2007)

The large-pore iron(III) carboxylate MIL-100(Fe) with a zeotype architecture has been isolated under hydrothermal conditions, its structure solved from synchrotron X-ray powder diffraction data, while Friedel-Crafts benzylation catalytic tests indicate a high activity and selectivity for MIL-100(Fe).
Vascular endothelial growth factor in patients with psoriatic arthritis. (2007)

VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway (2017)

Oxidative stress causes significant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofuscin. Here we show that HPβCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression. In the absence of oxidative stress, HPβCD addition induces a paradoxical response, increasing cholesterol accumulation (but not lipofuscin) via upregulation of cholesterol biosynthesis. These two distinct, but opposite effects highlight a previously overlooked therapeutic consideration: the cholesterol content of the treated cell determines which cholesterol pathways, either beneficial or harmful, are responsive to HPβCD.