gebhart/patrepeval huggingface dataset:
Multichannel mesh networks: challenges and protocols (2006)

Supporting high throughput is an important challenge in multihop mesh networks. Popular wireless LAN standards, such as IEEE 802.11, provision for multiple channels. In this article, we consider the use of multiple wireless channels to improve network throughput. Commercially available wireless network interfaces can typically operate over only one channel at a time. Due to cost and complexity constraints, the total number of interfaces at each host is expected to be smaller than the total channels available in the network. Under this scenario, several challenges need to be addressed before all the available channels can be fully utilized. In this article, we highlight the main challenges, and present two link-layer protocols for utilizing multiple channels. We also present a new abstraction layer that simplifies the implementation of new multichannel protocols in existing operating systems. This article demonstrates the feasibility of utilizing multiple channels, even if each host has fewer interfaces than the number of available channels.
Molecular Genetics of Neuronal Recognition in Drosophila: Evolution and Function of Immunoglobulin Superfamily Cell Adhesion Molecules (1990)

One form of neuronal recognition is the remarkable selectivity shown by neuronal growth cones in their ability to recognize and extend along specific axonal surfaces, a process called selective fasciculation. At the Cold Spring Harbor Symposium on Molecular Neurobiology in 1983, Raper, Bastiani, and Goodman (1983c) proposed on the basis of a long series of descriptive and experimental studies on the mechanisms of selective fasciculation in the grasshopper (Raper et al. 1983 a,b, 1984; Bastiani et al. 1984) that neighboring axon pathways must be differentially labeled by surface recognition molecules, which allow growth cones to distinguish among them—a notion they called the labeled pathways hypothesis. Subsequent cellular analysis from our laboratory in both the grasshopper (Bastiani et al. 1986; Doe et al. 1986; du Lac et al. 1986) and a simple vertebrate (the fish spinal cord; see Kuwada 1986) further supported this hypothesis. At about the same time, other studies...
Functional association between promoter structure and transcript alternative splicing (1997)

It has been assumed that constitutive and regulated splicing of RNA polymerase II transcripts depends exclusively on signals present in the RNA molecule. Here we show that changes in promoter structure strongly affect splice site selection. We investigated the splicing of the ED I exon, which encodes a facultative type III repeat of fibronectin, whose inclusion is regulated during development and in proliferative processes. We used an alternative splicing assay combined with promoter swapping to demonstrate that the extent of ED I splicing is dependent on the promoter structure from which the transcript originated and that this regulation is independent of the promoter strength. Thus, these results provide the first evidence for coupling between alternative splicing and promoter-specific transcription, which agrees with recent cytological and biochemical evidence of coordination between splicing and transcription.
Multidose pharmacokinetics of factor IX: implications for dosing in prophylaxis (1998)

The aim of this study was to investigate the use of single-dose pharmacokinetic data for factor IX (FIX) to predict multidose pharmacokinetics and explore their use for pharmacokinetic dosing in prophylactic treatment of haemophilia B. Eight patients with severe haemophilia B were enrolled. Using single-dose pharmacokinetic data for each patient, plasma factor IX procoagulant activity (FIX:C) curves during prophylactic dosing were computer-simulated. The simulations were verified by repeated blood sampling and measurements of FIX:C. Theoretical dosing regimens to maintain a plasma trough level of 1.0 U dL-1 of FIX:C were calculated. A 2 x 2 week cross-over study on standard dosing according to bodyweight vs. dosing every three days based on individual pharmacokinetics was carried out. FIX:C was measured during each treatment period. FIX:C data from the plasma sampling generally confirmed the single-dose pharmacokinetic data used. Pharmacokinetically tailored dosing of FIX could result in considerable savings of factor concentrate as compared to current standard dosing. The study demonstrates the applicability of individual pharmacokinetics as a tool for cost-effective utilization of FIX concentrates in the prophylactic treatment of haemophilia B.
The Free Press: Essential to Robust Debates (1990)

It is exciting to be a part of this reception tendered to the 1989-1990 Pace Law Review Associates.Indeed, it is a delight just to be at Pace Lawwith its 800 challenging students, 47 percent of whom are women, its ever gracious staff, its highly regarded faculty and its dynamic administration.Thank you, each one of you, for making me feel so welcome.You have demonstrated that you are keenly interested in exertions to establish and maintain high standards for the legal profession.Pace Law Review, born only a decade ago, is an exemplar of such an effort.Consistently offering quality material submitted by students and outside authors of reknown, the Review functions to apprise its readers of recent developments in
RTOS Support for Parallel Execution of Hard Real-Time Applications on the MERASA Multi-core Processor (2010)

Multi-cores are the contemporary solution to satisfy high performance and low energy demands in general and embedded computing domains. However, currently available multi-cores are not feasible to be used in safety-critical environments with hard real-time constraints. Hard real-time tasks running on different cores must be executed in isolation or their interferences must be time-bounded. Thus, new requirements also arise for a real-time operating system (RTOS), in particular if the parallel execution of hard real-time applications should be supported. In this paper we focus on the MERASA system software as an RTOS developed on top of the MERASA multi-core processor. The MERASA system software fulfils the requirements for time-bounded execution of parallel hard real-time tasks. In particular we focus on thread control with synchronisation mechanisms, memory management and resource management requirements. Our evaluations show that all system software functions are time-bounded by a worst-case execution time (WCET) analysis.
v-Triazolo[4,5-d]pyrimidines. II. O-Substituted Derivatives of 8-Azaguanine and 8-Azahypoxanthine1 (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTv-Triazolo[4,5-d]pyrimidines. II. O-Substituted Derivatives of 8-Azaguanine and 8-Azahypoxanthine1Y. Fulmer Shealy, Joe D. Clayton, C. Allen O'Dell, and John A. MontgomeryCite this: J. Org. Chem. 1962, 27, 12, 4518–4523Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a096https://doi.org/10.1021/jo01059a096research-articleACS PublicationsRequest reuse permissionsArticle Views445Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid (2001)

3-Guanidinopropionic acid (1) has been demonstrated both to improve insulin sensitivity and to promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 has also been shown to be a substrate for both the creatine transporter and creatine kinase, leading to marked accumulation in muscle tissue as the corresponding N-phosphate. The corresponding aminoguanidine analogue 2 was recently discovered to retain the antidiabetic activity of 1 while being markedly less susceptible to creatine-like metabolism, suggesting that it should have less potential to accumulate in muscle. Further structural modification of 2 was undertaken to investigate whether the antidiabetic potency could be augmented while maintaining resistance to creatine-like metabolism. Modifications such as alpha-alkylation, homologation, and bioisosteric replacement of the aminoguanidine all were detrimental to antidiabetic activity. However, the simple regioisomeric aminoguanidinoacetic acid 9 and diaminoguanidinoacetic acid analogue 7 were found to be equipotent to 2, leading eventually to the discovery of the significantly more potent diaminoguanidinoacetic acid regioisomers 52 and 53. Further attempts to modify the more active template represented by 52 led only to reductions in antidiabetic activity. Each of the new active analogues displayed the same resistance to creatine-like metabolism as 2. Further testing of 7, 9, and 53 in obese diabetic ob/ob mice confirmed that weight loss is induced selectively from adipose tissue, similar to the lead 1. Administration of 53 to insulin-resistant rhesus monkeys led to reductions in both fasting and post-prandial plasma glucose levels with concomitant reductions in plasma insulin levels, suggesting that the compound improved the action of endogenous insulin. Compounds 7 and 53 were selected for further preclinical development.
Transgenic Inhibition of Astroglial NF-κB Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation (2009)

In the CNS, the transcription factor NF-kappaB is a key regulator of inflammation and secondary injury processes. Following trauma or disease, the expression of NF-kappaB-dependent genes is activated, leading to both protective and detrimental effects. In this study, we show that transgenic inactivation of astroglial NF-kappaB (glial fibrillary acidic protein-IkappaB alpha-dominant-negative mice) resulted in reduced disease severity and improved functional recovery following experimental autoimmune encephalomyelitis. At the chronic stage of the disease, transgenic mice exhibited an overall higher presence of leukocytes in spinal cord and brain, and a markedly higher percentage of CD8(+)CD122(+) T regulatory cells compared with wild type, which correlated with the timing of clinical recovery. We also observed that expression of proinflammatory genes in both spinal cord and cerebellum was delayed and reduced, whereas the loss of neuronal-specific molecules essential for synaptic transmission was limited compared with wild-type mice. Furthermore, death of retinal ganglion cells in affected retinas was almost abolished, suggesting the activation of neuroprotective mechanisms. Our data indicate that inhibiting NF-kappaB in astrocytes results in neuroprotective effects following experimental autoimmune encephalomyelitis, directly implicating astrocytes in the pathophysiology of this disease.
Acoustic Scene Classification: Classifying environments from the sounds they produce (2015)

In this article, we present an account of the state of the art in acoustic scene classification (ASC), the task of classifying environments from the sounds they produce. Starting from a historical review of previous research in this area, we define a general framework for ASC and present different implementations of its components. We then describe a range of different algorithms submitted for a data challenge that was held to provide a general and fair benchmark for ASC techniques. The data set recorded for this purpose is presented along with the performance metrics that are used to evaluate the algorithms and statistical significance tests to compare the submitted methods.
Excited-state properties of a triply ortho-metalated iridium(III) complex (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExcited-state properties of a triply ortho-metalated iridium(III) complexK. A. King, P. J. Spellane, and Richard J. WattsCite this: J. Am. Chem. Soc. 1985, 107, 5, 1431–1432Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00291a064https://doi.org/10.1021/ja00291a064research-articleACS PublicationsRequest reuse permissionsArticle Views5921Altmetric-Citations591LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BET1, BOS1, and SEC22 are members of a group of interacting yeast genes required for transport from the endoplasmic reticulum to the Golgi complex. (1990)

A subset of the genes required for transport from the endoplasmic reticulum (ER) to the Golgi complex in Saccharomyces cerevisiae was found to interact genetically. While screening a yeast genomic library for genes complementing the ER-accumulating mutant bet1 (A. Newman and S. Ferro-Novick, J. Cell Biol. 105: 1587-1594, 1987), we isolated BET1 and BOS1 (bet one suppressor). BOS1 suppresses bet1-1 in a gene dosage-dependent manner, providing greater suppression when it is introduced on a multicopy vector than when one additional copy is present. The BET1 and BOS1 genes are not functionally equivalent; overproduction of BOS1 does not alleviate the lethality associated with disruption of BET1. We also identified a pattern of genetic interactions among these genes and another gene implicated in transport from the ER to the Golgi complex: SEC22. Overproduction of either BET1 or BOS1 suppresses the growth and secretory defects of the sec22-3 mutant over a wide range of temperatures. Further evidence for genetic interaction was provided by the finding that a bet1 sec22 double mutant is inviable. Another mutant which is blocked in transport from the ER to the Golgi complex, sec21-1, demonstrates a more limited ability to be suppressed by the BET1 gene. The interactions we observed are specific for genes required for transport from the ER to the Golgi complex. The products of the genes involved are likely to have a direct role in transport, as bet1-1 and sec22-3 begin to display their mutant phenotypes within 5 min of a shift to the restrictive temperature.
Differential Requirements for OX40 Signals on Generation of Effector and Central Memory CD4+ T Cells (2007)

Memory T cells can be divided into effector memory (T(EM)) and central memory (T(CM)) subsets based on their effector function and homing characteristics. Although previous studies have demonstrated that TCR and cytokine signals mediate the generation of the two memory subsets of CD8(+) T cells, the mechanisms for generation of the CD4(+) T(EM) and T(CM) cell subsets are unknown. We found that OX40-deficient mice showed a marked reduction in the number of CD4(+) T(EM) cells, whereas the number of CD4(+) T(CM) cells was normal. Adoptive transfer experiments using Ag-specific CD4(+) T cells revealed that OX40 signals during the priming phase were indispensable for the optimal generation of the CD4(+) T(EM), but not the CD4(+) T(CM) population. In a different transfer experiment with in vitro established CD4(+)CD44(high)CD62L(low) (T(EM) precursor) and CD4(+)CD44(high)CD62L(high) (T(CM) precursor) subpopulations, OX40-KO T(EM) precursor cells could not survive in the recipient mice, whereas wild-type T(EM) precursor cells differentiated into both T(EM) and T(CM) cells. In contrast, T(CM) precursor cells mainly produced T(CM) cells regardless of OX40 signals, implying the dispensability of OX40 for generation of T(CM) cells. Nevertheless, survival of OX40-KO T(EM) cells was partially rescued in lymphopenic mice. During in vitro recall responses, the OX40-KO T(EM) cells that were generated in lymphopenic recipient mice showed impaired cytokine production, suggesting an essential role for OX40 not only on generation but also on effector function of CD4(+) T(EM) cells. Collectively, the present results indicate differential requirements for OX40 signals on generation of CD4(+) T(EM) and T(CM) cells.
Prophylactic Catheter Ablation for the Prevention of Defibrillator Therapy (2007)

In this randomized trial, prophylactic substrate-based catheter ablation reduced the incidence of ICD therapy in patients with a history of myocardial infarction who received ICDs for the secondary prevention of sudden death. (Current Controlled Trials number, ISRCTN62488166 [controlled-trials.com].).
Kinetics of the dissociation of indium-(para-substituted-benzyl)ethylenediaminetetraacetic acid hapten analogs from the monoclonal anti-hapten antibody CHA255 (1990)

Half-lives were measured for the dissociation of a series of 20 indium-benzyl-EDTA derivatives from a monoclonal antibody that binds to them. Most haptens gave expected monoexponential dissociation curves with half-lives ranging from approximately 8 to approximately 100 min at 22 +/- 1 degree C. Precise (+/- approximately 2.5%) determinations were made using centrifugal ultrafiltration to separate free from bound hapten. A strong pH dependence of the dissociation half-life was found for the two haptens studied. Activation enthalpies were identical (23 +/- 1 kcal/mol) for the dissociation of four haptens, suggesting that, in contrast to individual rate constants, this parameter is insensitive to hapten modification. The dissociation half-lives provided evidence for the location of a positive charge in the binding site, but gave no clear indication of the role of hydrophobic interactions or of steric requirements in hapten binding. While variations in ionic strength had no effect on the dissociation rate, lowering surface tension with dioxane increased the rate somewhat. Three hapten-antibody complexes showed biexponential dissociation rates. It is postulated that this results from distinct conformations of the complex dissociating at different rates. The dissociation rate constant was found to be an extremely sensitive indicator of the hapten-antibody interaction that can be measured very precisely.
Theory, design, and performance of extended tuning range semiconductor lasers with sampled gratings (1993)

The authors have recently demonstrated 57 nm of tuning in a monolithic semiconductor laser using conventional distributed-Bragg-reflector (DBR) technology with grating elements removed in a periodic fashion. They describe the theory and design of these so-called sampled-grating tunable lasers. They calculate sample-grating reflectivity, and present normalized design curves which quantify tradeoffs involved in a sampled-grating DBR laser with two mismatched sampled-grating mirrors. These results are applied to a design example in the InP-InGaAsP system. The design provides 70-nm tuning while maintaining >30-dB mode suppression ratio (MSR), with fractional index change Delta mu / mu <0.2% in the mirrors, and only 1 mm of total sampled-grating length.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Immunoliposome Targeting to Mesangial Cells (2005)

Mesangial cell-mediated nephropathies are a frequent cause of ESRD. Specific drug delivery to mesangial cells might be more effective and better tolerated than existing systemic treatments. Rat mesangial cells are characterized by Thy1.1 antigen expression. Therefore, OX7-coupled immunoliposomes (OX7-IL) were prepared by coupling liposomes with F(ab') fragments of OX7 mAb directed against Thy1.1 antigen. As the glomerular endothelium is fenestrated and no basement membrane separates glomerular capillaries from the mesangium, mesangial cells represent a particularly suitable target for drug delivery by OX7-IL. Therefore, the targeting efficacy of OX7-IL to mesangial cells was investigated. Specific targeting in vitro was obtained, and intravenous injection of OX-7-IL to rats showed a specific targeting of all mesangial cells in both kidneys. OX7-IL showed marked accumulation in the cytoplasm of rat mesangial cells, both in vitro and in vivo. This renal targeting was blocked when free OX7 F((ab')2) fragments were co-administered with OX7-IL. Rats that were given a single intravenous injection of low-dose doxorubicin encapsulated in OX7-IL showed extensive glomerular damage, whereas other parts of the kidney and other organs were spared. Free doxorubicin and the liposomal formulation of this agent had no effect. Thus, immunoliposomes are a very promising delivery system for the treatment of kidney diseases.
A metalloproteinase associated with gelonin, a "ribosome inactivating protein". (1985)

Gelonin, a single-chain protein which inactivates eukaryotic ribosomes, becomes split into peptides when incubated with SDS. During the chromatographic purification of gelonin on carboxymethylcellulose three overlapping peaks emerge in the gelonin elution region, containing three proteins with small differences in apparent molecular weight (31,500, 30,000 and 29,200). All three proteins are endowed with inhibitory activity on protein synthesis and with proteinase activity, although with different specific activities, and all three give rise to the same peptides upon incubation with SDS, suggesting that they are isoforms of gelonin. The gelonin-associated proteinase acts only on gelonin, while it is inactive on the most common substrates for endoproteinases. The proteolytic activity is not inhibited by inhibitors of serine- or SH-proteinases, while it is completely abolished by chelating agents. Divalent cations restore the proteolytic activity inhibited by EDTA. The stability of the proteinase activity on exposure of gelonin to extreme values of pH or to prolonged incubation has been investigated. The inhibitory activity on protein synthesis and the proteinase activity are differently affected by these treatments.