gebhart/patrepeval huggingface dataset:
Luminescence of Eu2+ in barium and strontium aluminate and gallate (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLuminescence of Eu2+ in barium and strontium aluminate and gallateS. H. M. Poort, W. P. Blokpoel, and G. BlasseCite this: Chem. Mater. 1995, 7, 8, 1547–1551Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/cm00056a022https://doi.org/10.1021/cm00056a022research-articleACS PublicationsRequest reuse permissionsArticle Views2624Altmetric-Citations385LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ASH1 Gene Is a Specific Therapeutic Target for Lung Cancers with Neuroendocrine Features (2005)

Lung cancers with neuroendocrine features are usually aggressive, although the underlying molecular mechanisms largely remain to be determined. The basic helix-loop-helix protein, achaete-scute complex-like 1/achaete-scute homologue 1 (ASH1), is expressed in normal fetal pulmonary neuroendocrine cells and lung cancers with neuroendocrine elements and is suggested to be involved in lung carcinogenesis. In the present study, we show inhibition of ASH1 expression by plasmid-based RNA interference (RNAi) to significantly suppress growth of lung cancer cells with ASH1 expression through G2-M cell cycle arrest and accumulation of sub-G1 populations, possibly linked to cleavage of caspase-9 and caspase-7. However, lung cancer cell lines without ASH1 expression and immortalized normal BEAS2B bronchial epithelial cells were not affected. The RNAi-resistant mutant ASH1 clearly induced rescue from G2-M arrest, suggesting a target-specific effect of RNAi. An ASH1-RNAi adenovirus was also established and significantly inhibited not only in vitro cell proliferation but also in vivo xenograft growth of ASH1-positive NCI-H460 cells. Elevated levels of apoptosis were also observed in NCI-H460 xenografts with the ASH1-RNAi adenovirus. The present study therefore suggests that ASH1 plays a crucial role in lung cancer development and may be an effective therapeutic target in lung cancers with neuroendocrine features.
Effects of Polymeric Electron Transporters and the Structure of Poly(p-phenylenevinylene) on the Performance of Light-Emitting Diodes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of Polymeric Electron Transporters and the Structure of Poly(p-phenylenevinylene) on the Performance of Light-Emitting DiodesMarko Strukelj, Timothy M. Miller, Fotis Papadimitrakopoulos, and Sehwan SonCite this: J. Am. Chem. Soc. 1995, 117, 48, 11976–11983Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/ja00153a018https://doi.org/10.1021/ja00153a018research-articleACS PublicationsRequest reuse permissionsArticle Views366Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Clinical Utility of Contemporary Molecular Cytogenetics (2008)

The development of microarray-based comparative genomic hybridization (array CGH) methods represents a critical new advance in molecular cytogenetics. This new technology has driven a technical convergence between molecular diagnostics and clinical cytogenetics, questioned our naïve understanding of the complexity of the human genome, revolutionized the practice of medical genetics, challenged conventional wisdom related to the genetic bases of multifactorial and sporadic conditions, and is poised to impact all areas of medicine. The use of contemporary molecular cytogenetic techniques in research and diagnostics has resulted in the identification of many new syndromes, expanded our knowledge about the phenotypic spectrum of recognizable syndromes, elucidated the genomic bases of well-established clinical conditions, and refined our view about the molecular mechanisms of some chromosomal aberrations. Newer methodologies are being developed, which will likely lead to a new understanding of the genome and its relationship to health and disease.
Changes in ventilation and its components in normal subjects during sleep. (1985)

Non-invasive measurements were made of ventilation, its derivatives, the contributions of abdomen and rib cage and arterial oxygen saturation in six healthy normal men whilst awake and during sleep. Minute ventilation fell significantly during slow wave (SW) sleep and rapid eye movement (REM) sleep (awake = 6.3 1 min-1, SW sleep = 5.7 1 min-1, REM sleep = 5.4 1 min-1; p less than 0.04). Mean inspiratory flow also fell significantly but timing was unchanged. The abdominal (diaphragmatic) contribution to ventilation fell very significantly during SW sleep but returned to awake levels during REM sleep (awake 54%, SW sleep 38%, REM sleep 56%; p less than 0.007). There were also significant falls in arterial oxygen saturation during SW and REM sleep (awake 97.3%, SW sleep 96.5%, REM sleep 96.2%; p less than 0.002). These falls represent reductions in arterial oxygen tension similar to those seen in patients with chronic airways obstruction and can be accounted for entirely by the associated reduction in ventilation.
A Novel Magnetic Actuation System for Miniature Swimming Robots (2011)

A novel mechanism for actuating a miniature swimming robot is described, modeled, and experimentally validated. Underwater propulsion is obtained through the interaction of mobile internal permanent magnets that move a number of polymeric flaps arranged around the body of the robot. Due to the flexibility of the proposed swimming mechanism, a different range of performances can be obtained by varying the design features. A simple multiphysics dynamic model was developed in order to predict basic behavior in fluids for different structural parameters of the robot. In order to experimentally verify the proposed mechanism and to validate the model, a prototype of the swimming robot was fabricated. The device is 35 mm in length and 18 mm in width and thickness, and the forward motion is provided by four flaps with an active length of 20 mm. The model was able to correctly predict flap dynamics, thrust, and energy expenditure for magnetic dragging within a spindle-frequency range going from 2 to 5 Hz. Additionally, the model was used to infer robot-thrust variation related to different spindle frequencies and a 25% increase in flap active length. Concerning swimming performance, the proposed technical implementation of the concept was able to achieve 37 mm/s with 4.9% magnetic mechanism efficiency.
Multiple Desensitization Mechanisms of Mechanotransducer Channels Shape Firing of Mechanosensory Neurons (2010)

How desensitization of mechanotransducer currents regulates afferent signal generation in mammalian sensory neurons is essentially unknown. Here, we dissected desensitization mechanisms of mechanotransducer channels in rat sensory neurons that mediate the sense of touch and pain. We identified four types of mechanotransducer currents that distribute differentially in cutaneous nociceptors and mechanoreceptors and that differ in desensitization rates. Desensitization of mechanotransducer channels in mechanoreceptors was fast and mediated by channel inactivation and adaptation, which reduces the mechanical force sensed by the transduction channel. Both processes were promoted by negative voltage. These properties of mechanotransducer channels suited them to encode the dynamic parameters of the stimulus. In contrast, inactivation and adaptation of mechanotransducer channels in nociceptors had slow time courses and were suited to encode duration of the stimulus. Thus, desensitization properties of mechanotransducer currents relate to their functions as sensors of phasic and tonic stimuli and enable sensory neurons to achieve efficient stimulus representation.
Mathematical model to predict regions of chromatin attachment to the nuclear matrix (1997)

The potentiation and subsequent initiation of transcription are complex biological phenomena. The region of attachment of the chromatin fiber to the nuclear matrix, known as the matrix attachment region or scaffold attachment region (MAR or SAR), are thought to be requisite for the transcriptional regulation of the eukaryotic genome. As expressed sequences should be contained in these regions, it becomes significant to answer the following question: can these regions be identified from the primary sequence data alone and subsequently used as markers for expressed sequences? This paper represents an effort toward achieving this goal and describes a mathematical model for the detection of MARs. The location of matrix associated regions has been linked to a variety of sequence patterns. Consequently, a list of these patterns is compiled and represented as a set of decision rules using an AND-OR formulation. The DNA sequence was then searched for the presence of these patterns and a statistical significance was associated with the frequency of occurrence of the various patterns. Subsequently, a mathematical potential value,MAR-Potential, was assigned to a sequence region as the inverse proportion to the probability that the observed pattern population occurred at random. Such a MAR detection process was applied to the analysis of a variety of known MAR containing sequences. Regions of matrix association predicted by the software essentially correspond to those determined experimentally. The human T-cell receptor and the DNA sequence from the Drosophila bithorax region were also analyzed. This demonstrates the usefulness of the approach described as a means to direct experimental resources.
Light signals and flowering (2006)

Physiological studies over a long period have shown that light acts to regulate flowering through the three main variables of quality, quantity, and duration. Intensive molecular genetic and genomic studies with the model plant Arabidopsis have given considerable insight into the mechanisms involved, particularly with regard to quality and photoperiod. For photoperiodism light, acting through phytochromes and cryptochromes, the main photomorphogenetic photoreceptors, acts to entrain and interact with a circadian rhythm of CONSTANS (CO) expression leading to transcription of the mobile floral integrator, FLOWERING LOCUS T (FT). The action of phytochromes and cryptochromes in photoperiodism is augmented by ZEITLUPE (ZTL) and FLAVIN-BINDING, KELCH REPEAT, F-BOX (FKF1) acting as accessory photoreceptors on entrainment and interaction, respectively. Light quality acts independently of the circadian system through Phytochromes B, D, and E to regulate FT. Light quantity effects, on the other hand, are still incompletely understood but are likely to be linked either directly or indirectly to patterns of assimilate partitioning and resource utilization within the plant.
Group tenant based SaaS application (2014)

With the continuous development in the IT new technologies like Cloud Computing, Big data have emerged and found its application in almost every area including education sector. Cloud computing delivers many services like platform as a service, Infrastructure as a service but the software as a service has made a tremendous impact in the software industry. Today education is considered to be one of the basic necessity after food, clothing and shelter of any individual. Thus the number of individuals taking up education has increased and is continuously increasing along with the need for delivering better education. Thus the amount of data to be managed by the institutions is increasing every day which has aroused the need for better Educational Enterprise Resource Planning(EERP). Also the processing done on the data though not frequent but when done it is always on large amount of data. In such scenario the conventional EERPs seem to be becoming unsuitable and insufficient to meet the changing needs of education system. Also these EERPs need to be installed at the premise of the college which leads to heavy investment for installation, its maintenance etc. Software as a service is the answer to the problems faced by the educational institutions which uses the same conventional EERPs developed by just changing the way the software is delivered to the users. The existing SaaS applications developed for the Educational institutions till today considers every college as separate tenant; however many a times there are tenants which have similar business functionalities and so can be grouped together to develop a single base SaaS application. This project report describes one such application EduSaaS which has been built up on the concept of grouping the tenants on the basis of the similarities in their business so that a single application can serve multiple users.
Prognostic Factors in Prostate Cancer (2000)

Abstract Background. —Under the auspices of the College of American Pathologists, a multidisciplinary group of clinicians, pathologists, and statisticians considered prognostic and predictive factors in prostate cancer and stratified them into categories reflecting the strength of published evidence and taking into account the expert opinions of the Prostate Working Group members. Materials and Methods. —Factors were ranked according to the previous College of American Pathologists categorical rankings: category I, factors proven to be of prognostic importance and useful in clinical patient management; category II, factors that have been extensively studied biologically and clinically but whose importance remains to be validated in statistically robust studies; and category III, all other factors not sufficiently studied to demonstrate their prognostic value. Factors in categories I and II were considered with respect to variations in methods of analysis, interpretation of findings, reporting of data, and statistical evaluation. For each factor, detailed recommendations for improvement were made. Recommendations were based on the following aims: (1) increasing uniformity and completeness of pathologic evaluation of tumor specimens, (2) enhancing the quality of data collected pertaining to existing prognostic factors, and (3) improving patient care. Results and Conclusions. —Factors ranked in category I included preoperative serum prostate-specific antigen level, TNM stage grouping, histologic grade as Gleason score, and surgical margin status. Category II factors included tumor volume, histologic type, and DNA ploidy. Factors in category III included perineural invasion, neuroendocrine differentiation, microvessel density, nuclear roundness, chromatin texture, other karyometric factors, proliferation markers, prostate-specific antigen derivatives, and other factors (oncogenes, tumor suppressor genes, apoptosis genes, etc).
A Randomized Crossover Evaluation of Antianginal Efficacy and Safety of Nitrolingual-Spray and Nitroglycerin Tablet Form in Coronary Artery Disease Patients (2000)

Twenty-eight coronary artery disease patients with more than 50% stenosis in at least one major coronary artery completed this randomized crossover clinical trial for the comparison of efficacy and safety of Nitrolingual-Spray and nitroglycerin (NTG) tablets. Exercise time was lengthened to 399.1 s (spray) or 408.5 s (tablets), compared to a baseline of 387.3 s. Ischemic burden decreased to about -4.0 mm with both forms, compared to -7.5 mm at baseline (ANOVA: p = 0.003). The ischemic time improved to 137.2 s (spray) or 152.9 s (tablets), compared to 253.4 s at baseline (ANOVA: p = 0. 005). Patients taking tablets experienced more episodes of hypotension and/or headache compared to patients taking the spray. Nitrolingual-Spray is as effective and safe as NTG tablets for the treatment of symptomatic coronary heart disease.
A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C. (1994)

We report the cloning and expressing of rat natriuretic peptide receptor-C (NPR-C), which binds naturally occurring and synthetic ligands with higher affinity than human NPR-C. Using rat/human hybrids and site-directed mutagenesis, we identified residue 188, Ala for rat and Ile for human, which modulates hormone binding. Orthologous mutagenesis at position 188 for either rNPR-C or hNPR-C results in a complete reversal of the pharmacology. To our knowledge, this is the first example of a single transmembrane domain receptor for which a single residue dictates the ligand binding properties; previous examples are limited to seven transmembrane receptors.
Small Multifunctional Nanoclusters (Nanoroses) for Targeted Cellular Imaging and Therapy (2009)

The ability of 20-50 nm nanoparticles to target and modulate the biology of specific types of cells will enable major advancements in cellular imaging and therapy in cancer and atherosclerosis. A key challenge is to load an extremely high degree of targeting, imaging, and therapeutic functionality into small, yet stable particles. Herein we report approximately 30 nm stable uniformly sized near-infrared (NIR) active, superparamagnetic nanoclusters formed by kinetically controlled self-assembly of gold-coated iron oxide nanoparticles. The controlled assembly of nanocomposite particles into clusters with small primary particle spacings produces collective responses of the electrons that shift the absorbance into the NIR region. The nanoclusters of approximately 70 iron oxide primary particles with thin gold coatings display intense NIR (700-850 nm) absorbance with a cross section of approximately 10(-14) m(2). Because of the thin gold shells with an average thickness of only 2 nm, the r(2) spin-spin magnetic relaxivity is 219 mM(-1) s(-1), an order of magnitude larger than observed for typical iron oxide particles with thicker gold shells. Despite only 12% by weight polymeric stabilizer, the particle size and NIR absorbance change very little in deionized water over 8 months. High uptake of the nanoclusters by macrophages is facilitated by the dextran coating, producing intense NIR contrast in dark field and hyperspectral microscopy, both in cell culture and an in vivo rabbit model of atherosclerosis. Small nanoclusters with optical, magnetic, and therapeutic functionality, designed by assembly of nanoparticle building blocks, offer broad opportunities for targeted cellular imaging, therapy, and combined imaging and therapy.
Immunization of mice with induced mutants ofCoccidioides immitis (1971)

Induced auxotrophic mutants of a human isolate of Coccidioides immitis were characterized as to their infection and/or disease causing capacity by intratesticular injection into guinea-pigs and by intranasal instillation into mice. These mutant strains demonstrated degrees of attenuation of virulence to avirulence. Considering this variability in infectivity, 3 of these strains were used as viable vaccines in mice. The results indicate that the individual mutants must produce a primary infection to establish immunity, and that effective immunity can be established which protects against infection up to a certain challenge dosage. Increasing the dosage of the vaccinating strain is given as a means of increasing the immunity of mice. Other characteristics of these mutants which may be related to their attenuation e.g. their nutritional requirements and growth temperature range, are discussed.
Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli (2005)

Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid.
Identification of Healed Terminal DNA Fragments in Linear Minichromosomes of Schizosaccharomyces pombe (1987)

The minichromosome Ch16 of the fission yeast Schizosaccharomyces pombe is derived from the centromeric region of chromosome III. We show that Ch16 and a shorter derivative, Ch12, made by gamma-ray cleavage, are linear molecules of 530 and 280 kilobases, respectively. Each minichromosome has two novel telomeres, as shown by genomic Southern hybridization with an S. pombe telomere probe. Comparison by hybridization of the minichromosomes and their chromosomal counterparts showed no signs of gross rearrangement. Cosmid clones covering the ends of the long arms of Ch16 and Ch12 were isolated, and subcloned fragments that contained the breakage sites were identified. They are apparently unique in the genome. By hybridization and Bal 31 digestion, the ends appear to consist of the broken-end sequences directly associated with short stretches (about 300 base pairs) of new DNA that hybridizes to a cloned S. pombe telomere. They do not contain the telomere-adjacent repeated sequences that are present in the normal chromosomes. The sizes of the short telomeric stretches are roughly the same as those of the normal chromosomes. Our results show that broken chromosomal ends in S. pombe can be healed by the de novo addition of the short telomeric repeats. The formation of Ch16 must have required two breakage-healing events, whereas a single cleavage-healing event in the long arm of Ch16 yielded Ch12.
Efficient electrocatalytic oxygen reduction over metal free-nitrogen doped carbon nanocapsules (2011)

Nitrogen doped carbon nanocapsules (NCNCs) were synthesized as a non-noble electrocatalyst for the ORR using a simple and efficient route. The NCNCs exhibited higher activity than the commercial Pt/C catalyst, excellent stability, and resistance to methanol oxidation in the oxygen reduction reaction.
Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues (2008)

Tissues from patients diagnosed with prostate cancer and PIN exhibit, on average, locally increased SMO expression in regions of prostatic disease and higher overall SMO expression in prostatic epithelial cells compared to healthy individuals. Further studies are warranted to directly examine the role of SMO-produced ROS in prostate carcinogenesis.