gebhart/patrepeval huggingface dataset:
Alternative Drilling Fluid Weighting Agents: A Comprehensive Study on Ilmenite and Hematite (2014)

Abstract For many years, barite has been the standard weighting agent in the drilling fluid industry. Its high specific gravity has helped produce mud weights in excess of 19 lb/gal. Its hardness has rendered it easily millable to a particle size that reduces settling and minimizes losses on shaker screens and its adequate inertness has enabled it to be used in a wide range of drilling fluids containing different chemical components. Recently, however, dwindling supplies and increased consumption of premium barite have led to significant price increases across the world and a reduction in specific gravity in most commercial grades. This has led to renewed interest in alternative weight materials. Ilmenite and hematite are two minerals that have been used sporadically in the field. Compared to barite, their higher density impacts both the rheology of the fluids and the settling rate of the weight material. A known issue with these materials is their relatively high hardness, which can give rise to abrasion/erosion in the tubular and surface equipment. Another effect that has not been addressed sufficiently is the magnetic characteristic of these iron oxide-containing minerals which has the potential to affect the operation of direction drilling and some other downhole tools. There have been many studies on the use of ilmenite and hematite as weight agents for drilling fluids. These have dealt with the above issues individually or in a scattered manner. In this paper, we report the results of a comprehensive laboratory study on the application of ilmenite and hematite as weight materials for both water- and oil-based drilling fluids. The study includes the effects of different size grades of the materials on rheology and fluid loss, as well as dynamic and static sag. The paper will present relative abrasiveness of the materials compared to barite as measured by two different methods, and recommend size grades that can minimize the abrasion effects. The paper will also report the results of magnetic property measurements which impact operation of several downhole tools, and compares these with that of barite and several other minerals. To complete the comparative testing of these minerals, the results of heavy metal analysis will also be reported for each test mineral.
Comparison of 3D Structures and AT1 Binding Properties of Pyrazolidine-3,5-diones and Tetrahydropyridazine-3,6-diones with Parent Antihypertensive Drug Irbesartan (2002)

A new series of nonpeptide AT(1) receptor antagonists were recently developed, based on the structure of irbesartan (Le Bourdonnec et al. J. Med. Chem. 2000, 43, 2685-2697). The lead compound 1 displayed high selectivity for the AT(1) receptor subtype but lower binding affinity than irbesartan. As expected from molecular modeling studies, extension of the pyrazolidine-3,5-dione scaffold to the six-membered heterocycle tetrahydropyridazine-3,6-dione led to an enhancement of the binding affinity toward the AT(1) receptor.
Clinical and echocardiographic correlates of intra-atrial conduction delay (2011)

This study is the largest to investigate the relation between the atrial conduction time, underlying heart diseases, and echocardiographic parameters. We found that the PA-TDI was independently prolonged in patients with a history of AF, hypertension, valve disease, higher age, and a higher BMI. Signs of diastolic dysfunction, valve incompetence, and enlarged atrium or aortic root on the echocardiogram were associated with a prolonged PA-TDI. This suggests that early and aggressive treatment of hypertension, diastolic dysfunction, and obesity could prevent intra-atrial conduction delay.
Regulation of meristem organization and cell division byTSO1, anArabidopsisgene with cysteine-rich repeats (2000)

In higher plants, meristem organization and cell division regulation are two fundamentally important and intimately related biological processes. Identifying and isolating regulatory genes in these processes is essential for understanding higher plant growth and development. We describe the molecular isolation and analyses of an Arabidopsis gene, TSO1, which regulates both of these processes. We previously showed that tso1 mutants displayed defects in cell division of floral meristem cells including partially formed cell walls, increased DNA content, and multinucleated cells (Liu, Z., Running, M. P. and Meyerowitz, E. M. (1997). Development 124, 665-672). Here, we characterize a second defect of tso1 in influorescence meristem development and show that the enlarged influorescence in tso1 mutants results from repeated division of one inflorescence meristem into two or more influorescence meristems. Using a map-based approach, we isolated the TSO1 gene and found that TSO1 encodes a protein with cysteine-rich repeats bearing similarity to Drosophila Enhancer of zeste and its plant homologs. In situ TSO1 mRNA expression pattern and the nuclear localization of TSO1-GFP are consistent with a regulatory role of TSO1 in floral meristem cell division and in influorescence meristem organization.
A New Method for the Extraction of R Lipopolysaccharides (1969)

A method is described which is specific for the extraction of lipopolysaccharides from R form bacteria. The extraction mixture which is monophasic, consists of aqueous phenol, chloroform and petroleum ether. R form lipopolysaccharides (glycolipids). due to their lipophilic nature, are completely soluble in the mixture. S and T form lipopolysaccharides as well as proteins, nucleic acids, and polysaccharides, are insoluble, and they are excluded from the extracts. The method is mild, as it can be carried out at below 10°. The yields are generally higher than those obtained by phenol‐water extraction, and the products are usually water‐soluble. Lipopolysaccharides have been successfully extracted from all R form bacteria so far attempted.
Applications of approximate word matching in information retrieval (1997)

As more online databases are integrated into digital libraries, the issue of quality control of the data becomes increasingly important, especially as it relates to the effective retrieval of information. The need to discover and reconcile variant forms of strings in bibliographic entries, i.e., authority work, will become more difficult. Spelling variants, misspellings, and transliteration differences will all increase the difficulty of retrieving information. Approximate string matching has traditionally been used to help with this problem. In this paper we introduce the notion of approximate word matching and show how it can be used to improve detection and categorization of variant forms.
Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism (1999)

Signaling by extracellular nucleotides through P2 purinergic receptors affects diverse macrophage functions; however, its role in regulating antimicrobial radicals during bacterial infection has not been investigated. Mycobacterium tuberculosis-infected macrophages released ATP in a dose-dependent manner, which correlated with nitrite accumulation. P2 receptor inhibitors, including oxidized ATP, blocked NO synthase (NOSII) up-regulation and NO production induced by infection with M. tuberculosis or bacille Calmette-Guérin, or treatment with LPS or TNF-alpha. Oxidized ATP also inhibited oxygen radical production and activation of NF-kappaB and AP-1 in response to infection and inhibited NO-dependent killing of bacille Calmette-Guérin by macrophages. Experiments using macrophages derived from P2X7 gene-disrupted mice ruled out an essential role for P2X7 in NOSII regulation. These data demonstrate that P2 receptors regulate macrophage activation in response to bacteria and proinflammatory stimuli, and suggest that extracellular nucleotides released from infected macrophages may enhance production of oxygen radicals and NO at sites of infection.
The chemistry of graphene (2010)

A review on the latest developments on graphene, written from the perspective of a chemist, is presented. The role of chemistry in bringing graphene research to the next level is discussed.
Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin (1982)

Nuclear magnetic resonance studies of 129Xe are consistent with one kinetically distinguishable binding environment in methemoglobin and two in metmyoglobin. The Xe binding site in methemoglobin is assigned to a cavity formed by the A-B and G-H corners of the globin chain [Schoenborn, B.P. (1965) Nature (London) 208, 760-762]. The small differences between alpha-hemoglobin and beta-hemoglobin are not resolved by the NMR experiments. The Xe association rate constant at 18 degrees C with methemoglobin is greater than 6 X 10(7) M-1 s-1 with an activation barrier of approximately 13 kcal/mol. One of the binding sites in metmyoglobin associated with a cavity on the proximal side of the porphyrin ring, opposite the O2 binding site [Schoenborn, B.P., Watson, H.C., & Kendrew, J.C. (1965) Nature (London) 207, 28-30]. An estimate of the association rate constant of Xe at 18 degrees C is 1 X 10(7) M-1 s-1 with an activation barrier of approximately 16 kcal/mol. The second metmyoglobin binding site has similar NMR and kinetic properties of those for methemoglobin.
Detective: Automatically identify and analyze malware processes in forensic scenarios via DLLs (2015)

Current memory forensic methods mainly focus on evidence collection and data recovery. A little work is about how to automatically identify malwares from many unknown processes and analyze their behaviors in high semantic level so as to collect related evidences. In fact, in real cases, investigators are often faced with large number of processes that they have no knowledge of. Although current malware detection tools could provide some help, they usually can't illustrate the purposes, abilities and behavior details of malwares and are thus often not fit for the forensic requirements. In this paper, we present a framework named Detective to cope with these issues. Given a set of unknown processes, Detective can classify benign and malware processes automatically. This is implemented by HNB classifying algorithm and a Dynamic-Link Libraries-based model. Detective could then explain malware behaviors in high semantic level through clustering and frequent item sets mining techniques. Besides, Detective sheds light on evidence collection by the information obtained from previous steps. Detective is applicable for both online and offline forensic scenarios. Experiments on real-world malware set have proved that the accuracy of Detective is above 90% and the time cost is only several seconds.
Semantic knowledge in word completion (2005)

We propose an integrated approach to interactive word-completion for users with linguistic disabilities in which semantic knowledge combines with $n$-gram probabilities to predict semantically more-appropriate words than $n$-gram methods alone. First, semantic relatives are found for English words, specifically for nouns, and they form the semantic knowledge base. The selection process for these semantically related words is first to rank the pointwise mutual information of co-occurring words in a large corpus and then to identify the semantic relatedness of these words by a Lesk-like filter. Then, the semantic knowledge is used to measure the semantic association of completion candidates with the context. Those that are semantically appropriate to the context are promoted to the top positions in prediction lists due to their high association with context. Experimental results show a performance improvement when using the integrated model for the completion of nouns.
Binding of p53 to the KIX Domain of CREB Binding Protein (1999)

The pleiotropic cellular coactivator CREB binding protein (CBP) plays a critical role in supporting p53-dependent tumor suppressor functions. p53 has been shown to directly interact with a carboxyl-terminal region of CBP for recruitment of the coactivator to p53-responsive genes. In this report, we identify the KIX domain as a new p53 contact point on CBP. We show that both recombinant and endogenous forms of p53 specifically interact with KIX. We demonstrate that the activation domain of p53 participates in KIX binding and provide evidence showing that this interaction is critical for p53 transactivation function. The human T-cell leukemia virus, type-I-encoded oncoprotein Tax is a well established repressor of p53 transcription function. Like p53, Tax also binds to KIX. The finding that both transcription factors bind to a common region of CBP suggests that coactivator competition may account for the observed repression. We demonstrate reciprocal repression between Tax and p53 in transient transfection assays, supporting the idea of intracellular coactivator competition. We biochemically confirm coactivator competition by directly showing that both transcription factors bind to KIX in a mutually exclusive fashion. These data provide molecular evidence for the observed intracellular competition and suggest that Tax inhibits p53 function by abrogating a novel p53-KIX interaction. Thus, Tax competition for the p53-KIX complex may be a pivotal event in the human T-cell leukemia virus, type I transformation pathway.
The 18mer peptaibols from Trichoderma virens elicit plant defence responses (2007)

SUMMARY Peptaibols, the products of non-ribosomal peptide synthetases (NRPS), are linear peptide antibiotics produced by Trichoderma and other fungal genera. Trichoderma virens strain Gv29-8, a well-known biocontrol agent and inducer of plant defence responses, produces three lengths of peptaibols, 11, 14 and 18 residues long, with several isoforms of each. Disruption of the NRPS gene, tex1, encoded by a 62.8-kb uninterrupted open reading frame, results in the loss of production of all forms of 18-residue peptaibols. Tex1 is expressed during all Trichoderma developmental stages (germinating conidia, sporulating and non-sporulating mycelia) examined on solid media. Expression analysis by reverse transcriptase PCR shows that in Gv29-8 wild-type the abundance of tex1 transcript is greater during co-cultivation with cucumber seedling roots than when grown alone. Cucumber plants co-cultivated with T. virens strains disrupted in tex1 show a significantly reduced systemic resistance response against the leaf pathogen Pseudomonas syringae pv. lachrymans, and reduced ability to produce phenolic compounds with inhibitory activity to the bacteria as compared with plants grown in the presence of wild-type. Two synthetic 18-amino-acid peptaibol isoforms (TvBI and TvBII) from Gv29-8 when applied to cucumber seedlings through the transpiration stream can alone induce systemic protection to the leaf pathogenic bacteria, induce antimicrobial compounds in cucumber cotyledons and up-regulate hydroxyperoxide lyase (hpl), phenylalanine ammonia lyase (pal1) and peroxidase (prx) gene expression. These data strongly suggest that the 18mer peptaibols are critical in the chemical communication between Trichoderma and plants as triggers of non-cultivar-specific defence responses.
Trans-gram, Fast Cross-lingual Word-embeddings (2015)

We introduce Trans-gram, a simple and computationally-efficient method to simultaneously learn and align wordembeddings for a variety of languages, using only monolingual data and a smaller set of sentence-aligned data. We use our new method to compute aligned wordembeddings for twenty-one languages using English as a pivot language. We show that some linguistic features are aligned across languages for which we do not have aligned data, even though those properties do not exist in the pivot language. We also achieve state of the art results on standard cross-lingual text classification and word translation tasks.
Magnetic entropy changes in nanogranular Fe:Ni61Cu39 (2011)

Artificial environment-friendly Gd-free magnetic nanostructures for magnetic cooling are investigated by temperature-dependent magnetic measurements. We consider two-phase nanocomposites where nanoclusters (Fe) are embedded in a Ni61Cu39 matrix. Several composite films are produced by cluster deposition. The average Fe cluster size depends on the deposition conditions and can be tuned by varying the deposition conditions. The quasiequilibrium Curie temperature of the Fe particles is high, but slightly lower than that of bulk Fe due to finite-size effects. Our experiments have focused on ensembles of 7.7 nm Fe clusters in a matrix with a composition close to Ni61Cu39, which has a TC of 180 K. The materials are magnetically soft, with coercivities of order 16 Oe even at relatively low temperature of 100 K. The entropy changes are modest, −ΔS = 0.05 J/kg K in a field change of 1 T and 0.30 J/kg K in a field change of 7 T at a temperature of 180 K, which should improve if the cluster size is reduced.
GenBank (1997)

The GenBank sequence database incorporates DNA sequences from all available public sources, primarily through the direct submission of sequence data from authors and from large-scale sequencing projects. Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive coverage. GenBank continues to focus on quality control and annotation while expanding data coverage and retrieval services. An integrated retrieval system, known asEntrez, incorporates data from the major DNA and protein sequence databases, along with genome maps and protein structure information. MEDLINE abstracts from published articles describing the sequences are also included as an additional source of biological annotation. Sequence similarity searching is offered through the BLAST family of programs. All of NCBI's services are offered through the World Wide Web. In addition, there are specialized server/client versions as well as FTP and e-mail server access.
ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA (1991)

Levels of iron, copper, zinc and manganese were measured by inductively coupled plasma spectroscopy in frozen postmortem brain tissue from patients with Parkinson's disease (PD), progressive supranuclear palsy (PSP), multiple system atrophy with strionigral degeneration (MSA), and Huntington's disease (HD) compared with control subjects. Total iron levels were found to be elevated in the areas of basal ganglia showing pathological change in these disorders. In particular, total iron content was increased in substantia nigra in PD, PSP and MSA, but not in HD. Total iron levels in the striatum (putamen and/or caudate nucleus) were increased in PSP, MSA and HD but not in PD. Total iron levels were decreased in the globus pallidus in PD. There were no consistent alterations of manganese levels in basal ganglia structures in any of the diseases studied. Copper levels were decreased in the substantia nigra in PD, and in the cerebellum in PSP, and were elevated in the putamen and possibly substantia nigra in HD. Zinc levels were only increased in PD, in substantia nigra and in caudate nucleus and lateral putamen. Levels of the iron binding protein ferritin were measured in the same patient groups using a radio-immunoassay technique. Increased iron levels in basal ganglia were generally associated with normal or elevated levels of ferritin immunoreactivity, for example, the substantia nigra in PSP and possibly MSA, and in putamen in MSA. The exception was PD where there was a generalized reduction in brain ferritin immunoreactivity, even in the substantia nigra. An increase in total iron content appears to be a response to neurodegeneration in affected basal ganglia regions in a number of movement disorders. However, only in PD was there an increased total iron level, decreased ferritin content, decreased copper content, and an increased zinc concentration in substantia nigra. These findings suggest an alteration of iron handling in the substantia nigra in PD. Depending on the form in which the excess iron load exists in nigra in PD, it may contribute to the neurodegenerative process.
Crystal orientation effects on electronic properties of wurtzite InGaN/GaN quantum wells (2002)

Crystal orientation effects on electronic properties of wurtzite InGaN/GaN quantum wells (QWs) with piezoelectric (PZ) and spontaneous (SP) polarization are investigated using the multiband effective-mass theory. With increasing crystal angle, the internal field of the InGaN/GaN QW structure changes its sign near the crystal angle of 55° while that of the GaN/AlGaN QW structure gradually decreases without changing its sign. The interband transition energy is redshifted for crystal angles near θ=0° and gradually increases with the crystal angle due to the reduced SP and PZ polarization effects. The y′-polarized optical matrix element largely increases with increasing crystal angle. This is mainly due to the fact that the states constituting the topmost valence subband near the band edge are predominantly |Y′〉-like for QW structures with larger crystal angle. Also, it is observed that the average hole effective mass is largely reduced with increasing crystal angle. In particular, the average hole effective mass of the (101̄0)-oriented QW structure are about four times smaller than that of the (0001)-oriented QW structure.
An Adenylate Cyclase-Controlled Signaling Network Regulates Pseudomonas aeruginosa Virulence in a Mouse Model of Acute Pneumonia (2004)

Infections caused by the opportunistic pathogen Pseudomonas aeruginosa involve the interplay of several bacterial virulence factors. It has recently been established that the delivery of toxic effector proteins by the type III secretion system is an important virulence mechanism in several animal models. Furthermore, the expression of the type III secretion system and its effectors has been correlated with a poor clinical outcome during human infections. A novel cyclic AMP (cAMP) regulatory network that controls the expression of virulence factors, including the type III secretion system, was examined to determine its contribution to P. aeruginosa colonization and dissemination in a mouse pneumonia model. Mutants lacking the two genome-encoded adenylate cyclases, CyaA and CyaB, and the cAMP-dependent regulator Vfr were examined. Based on the enumeration of bacteria in lungs, livers, and spleens, as well as the assessment of mouse lung pathology, mutations in the cyaB and vfr genes resulted in a more significantly attenuated phenotype than mutations in cyaA. Moreover, in this model, expression of the type III secretion system was essential for lung colonization and pathology. Strains with mutations in the exsA gene, which encodes a type III regulatory protein, or pscC, which encodes an essential component of the secretion apparatus, were also significantly attenuated. Finally, we demonstrate that virulence can be restored in an adenylate cyclase mutant by the overexpression of exsA, which specifically restores expression of the type III secretion system in the absence of a functional cAMP-dependent regulatory network.
Bone Marrow Transplantation for Aplastic Anaemia (1975)

S ummary . Indications for treatment of aplastic anaemia (AA) by marrow transplantation are discussed. Selection of donor‐recipient pairs by histocompatibility testing, conditioning of patients for transplantation, technique of grafting, post‐grafting care and immunosuppressive drug regimens are reviewed. Data are presented on 28 patients with advanced AA treated by marrow grafts from HL‐A matched siblings following conditioning with cyclophosphamide (50 mg/kg) on each of 4 successive days. Survival and haematological reconstitution in more than half the patients indicates that marrow grafting in patients with advanced AA should be undertaken early, before major infections and refractoriness to blood transfusions occur provided that an HL‐A matched sibling can be identified as a donor. The results have shown that survival in marrow grafted patients with severe AA compares favourably to that of patients treated with conventional therapy.