gebhart/patrepeval huggingface dataset:
MoteLab: a wireless sensor network testbed (2005)

As wireless sensor networks have emerged as a exciting new area of research in computer science, many of the logistical challenges facing those who wish to develop, deploy, and debug applications on realistic large-scale sensor networks have gone unmet. Manually reprogramming nodes, deploying them into the physical environment, and instrumenting them for data gathering is tedious and time-consuming. To address this need we have developed MoteLab, a Web-based sensor network testbed. MoteLab consists of a set of permanently-deployed sensor network nodes connected to a central server which handles re programming and data logging while providing a Web interface for creating and scheduling jobs on the testbed. MoteLab accelerates application deployment by streamlining access to a large, fixed network of real sensor network devices; it accelerates debugging and development by automating data logging, allowing the performance of sensor network software to be evaluated offline Additionally, by providing a Web interface MoteLab allows both local and remote users access to the testbed, and its scheduling and quota system ensure fair sharing. We have developed and deployed MoteLab at Harvard and found ft invaluable for both research and teaching. The MoteLab source is freely available, easy to install, and already in use at several other research institutions. We expect that widespread use of MoteLab will accelerate and improve wireless sensor network research.
A multi-sensor fusion system for moving object detection and tracking in urban driving environments (2014)

A self-driving car, to be deployed in real-world driving environments, must be capable of reliably detecting and effectively tracking of nearby moving objects. This paper presents our new, moving object detection and tracking system that extends and improves our earlier system used for the 2007 DARPA Urban Challenge. We revised our earlier motion and observation models for active sensors (i.e., radars and LIDARs) and introduced a vision sensor. In the new system, the vision module detects pedestrians, bicyclists, and vehicles to generate corresponding vision targets. Our system utilizes this visual recognition information to improve a tracking model selection, data association, and movement classification of our earlier system. Through the test using the data log of actual driving, we demonstrate the improvement and performance gain of our new tracking system.
Developmental expression of surface antigen genes in the parasitic ciliate Ichthyophthirius multifiliis. (1992)

A 1.2-kilobase (kb) cDNA encoding a major surface antigen of the holotrich ciliate Ichthyophthirius multifiliis (an obligate parasite of fish) has been isolated and used as a probe to examine the expression of immobilization antigen (i-antigen) genes in this system. The cDNA encodes a predicted protein of 394 amino acids with a tandemly repeated structure characteristic of the i-antigens of the related free-living ciliates Paramecium and Tetrahymena. As shown by Northern hybridization analysis with both total and poly(A)+ RNAs, the 1.2-kb cDNA recognizes distinct transcripts of 1.6 and 1.9 kb which are differentially expressed through the parasite life cycle. During the transition from the host-associated trophozoite stage to the infective tomite stage, steady-state levels of the 1.9-kb RNA undergo a marked increase of greater than or equal to 50-fold, while the 1.6-kb transcript increases only slightly. The absolute amounts of RNA encoding the i-antigen have been quantitated and were found to reach extremely high levels equivalent to approximately 6% of the poly(A)+ RNA of I. multifiliis tomites. Southern hybridization analysis with I. multifiliis genomic DNA suggests that at least two genes encode the i-antigen transcripts. In experiments to examine the effects of temperature on the expression of I. multifiliis i-antigen genes, levels of the 1.6- and 1.9-kb transcripts were found to remain relatively constant in cells maintained at different temperature extremes. These studies indicate that genes encoding i-antigens of I. multifiliis are developmentally regulated, and they suggest the existence of alternative mechanisms for the control of surface antigen expression in ciliates.
Synthesis of Spiro [4-hydroxycyclohexane-1, 4'-2', 3'-dihydm-6'-methoxy-1'-substituted-2'-methy1-1'<I>H</I>-isoquinoline] (1972)

For the purpose of testing the biological activity, some galanthamine related compounds, spiro [4-hydroxycyclohexane-1, 4'-2', 3'-dihydro-6'-methoxy-1'-substituted-2'-methy1-1'H-isoquinoline](IIIa, b, c) were synthesized by the application of the Bischler-Napieralski cyclization on the N-acyl compounds (VIIa, b, c).
Radiofrequency endocardial catheter ablation of accessory atrioventricular pathway atrial insertion sites. (1993)

The atrial insertion approach to accessory pathway ablation is safe and highly effective. This approach compares favorably with the retrograde ventricular insertion ablation technique. Atrial insertion ablation eliminates the need to produce ventricular lesions and avoids the risks of prolonged arterial catheter manipulation and retrograde left ventricular catheterization.
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter (2001)

Elevated serum levels of uric acid have been associated with an increased risk for gout, hypertension, cardiovascular disease, and renal failure. The molecular mechanisms for the diminished excretion of urate in these disorders, however, remain poorly understood. Human galectin 9, which is highly homologous to the rat urate transporter rUAT, has been reported to be a secreted or cytosolic protein. We provide data that galectin 9 is hUAT, the first identified human urate transporter. hUAT is a highly selective urate ion channel when inserted in lipid bilayers. When expressed in renal epithelial cells it is an integral plasma membrane protein with at least two transmembrane domains. The gene for hUAT consists of 11 exons and is mapped to chromosome 17; a highly homologous gene, hUAT2, maps to a nearby region of chromosome 17 and is also likely to be a urate transporter. hUAT is expressed in a wide variety of tissues and is present in at least three isoforms; hUAT2 is less widely expressed at severalfold lower levels than hUAT. Further knowledge about the functions of hUAT, its isoforms, and hUAT2, as well as mutational analysis of hUAT1 and hUAT2 in individuals or families with hyperuricemia, should significantly improve our understanding of the molecular mechanisms of urate homeostasis.
Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. (1994)

We identified germline p53 mutations in seven of 235 (3.0%) children with osteosarcoma. Four of these mutations were found in patients who did not have first-degree relatives with cancer. Although genetic transmission of the altered p53 gene could not be tested in this survey because of how it was designed, it is possible that predictive testing for p53 mutations could identify unaffected relatives of gene carriers who also have a high risk for the development of cancer. This study provides evidence for the importance of considering children with osteosarcoma for predictive testing for germline p53 mutations.
P300 Brain-Computer Interface Design for Communication and Control Applications (2005)

This paper introduces the design of a P300-based brain-computer interface (BCI) system. Based on this system, two applications are implemented: a word speller and a remote control device, which are to assist physically disabled people to communicate and control. A number of specific implementation techniques are proposed to achieve good performance in terms of accuracy and reliability. The word speller can achieve a spelling rate of up to 4-6 letters per minute, while both applications achieve 99% accuracy in our experiments with healthy subjects.
Thermal Behavior of β-1 Subunits in Lignin:  Pyrolysis of 1,2-Diarylpropane-1,3-diol-type Lignin Model Compounds (2007)

1,2-Diarylpropane-1,3-diol-type lignin model compounds, 1,2-bis(4-hydroxy-3-methoxyphenyl)propane-1,3-diol (1) and 1-(3,4-diethoxyphenyl)-2-(4-methoxyphenyl)propane-1,3-diol (2), were pyrolyzed at 500 degrees C for 4 s to clarify the thermal behavior of beta-1 subunits in lignin. Products were monitored by gas chromatography/mass spectrometry. The cleavage of the Calpha-Cbeta bond to produce benzaldehydes such as 4-hydroxy-3-methoxybenzaldehyde (9) and phenylethanals as the counterparts such as 4-hydroxy-3-methoxyphenylethanal (10) occurred in pyrolyses of both 1 and 2. In pyrolysis of 1, an oxetane pathway leading to the formation of Z/E-stilbenes without the gamma-CH2OH group such as Z/E-4,4'-dihydroxy-3,3'-dimethoxystilbene (3) was predominant. In pyrolysis of 2, the oxetane pathway was minor, while pathways producing a dimer with a =CgammaH2 group by loss of water and a dimer with an alpha-carbonyl group were predominant. Pyrolysis of Japanese cedar wood provided 3 and 10 in approximately 0.8% and 0.6% yields, respectively, based on the Klason lignin content, while pyrolysis of a guaiacyl bulk dehydrogenation polymer gave them in a very small amount.
System capability effects on algorithms for network bandwidth measurement (2003)

A large number of tools that attempt to estimate network capacity and available bandwidth use algorithms that are based on measuring packet inter-arrival time. However in recent years network bandwidth has become faster than system input/output (I/O) bandwidth. This means that it is getting harder and harder to estimate capacity and available bandwidth using these techniques. This paper examines the current bandwidth measurement and estimation algorithms, and presents an analysis of how these algorithms might work in a high-speed network environment. This paper also discusses the system resource (hardware and software) issues that affect each of these algorithms, especially running on generic platforms built from off-the-shelf components.
New fabrication process for Josephson tunnel junctions with (niobium nitride, niobium) double-layered electrodes (1982)

All hard Josephson tunnel junctions, whose base and counter electrodes are composed of double-layered niobium nitride (NbN) and niobium (Nb) films, have been successfully fabricated by isolating a junction sandwich formed on a whole silicon wafer with a reactive ion etching technique. The reactive ion etching technique has been used for patterning both base and counterelectrodes, and self-aligning definition of junction areas has been performed. The fabricated junctions show good quality single-particle tunneling characteristics and excellent uniformity in critical currents.
A randomized controlled study of modified cobratoxin in adrenomyeloneuropathy (2003)

Adrenomyeloneuropathy is a peroxisomal disorder that causes demyelination, with no proven therapy. Oral modified cobratoxin was assessed in a double-blind, randomized, crossover study of eight patients. Treatment was well tolerated. There were no significant improvements with therapy. The authors do not confirm previous anecdotal reports of dramatic improvement with modified cobratoxin.
Some Chemical Reactions of Trifluoromethyl Hypofluorite1 (1957)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Chemical Reactions of Trifluoromethyl Hypofluorite1Roger S. Porter and George H. CadyCite this: J. Am. Chem. Soc. 1957, 79, 21, 5625–5627Publication Date (Print):November 1, 1957Publication History Published online1 May 2002Published inissue 1 November 1957https://pubs.acs.org/doi/10.1021/ja01578a012https://doi.org/10.1021/ja01578a012research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Interleukin-6 Exacerbates Early Atherosclerosis in Mice (1999)

Acute-phase proteins, which respond to systemic proinflammatory cytokines such as interleuken-6, are elevated in cardiovascular disease and are predictive markers of future ischemic events, even over decades. This suggests a role for proinflammatory cytokines and/or acute phase proteins in early lesion development. To explore this issue, we fed C57Bl/6 and nonobese diabetic male mice high-fat (20% total fat, 1.5% cholesterol) diets and ApoE-deficient male mice both high-fat and normal chow diets for 6 to 21 weeks, injecting them weekly with either 5000 U recombinant interleukin-6 (rIL-6) or saline buffer. Blood was collected when animals were euthanized and assayed for cytokines, acute-phase proteins, and cholesterol. Across all mice, IL-6 injection resulted in significant increases in proinflammatory cytokines (IL-6, 4.6-fold; IL-1beta, 1.6-fold; and tissue necrosis factor-alpha, 1.7-fold) and fibrinogen (1.2-fold) and with decreased concentrations of albumin (0.9-fold) in plasma. Total cholesterol levels were unchanged between rIL-6-treated and nontreated groups. Serial sections through the aortic sinus were stained with oil red O to detect fatty streaks, and area of the lesions was determined by image analysis. Although no fatty streaks were detected in the nonobese diabetic mice with or without rIL-6 treatment, rIL-6 treatment increased lesion size in C57Bl/6 and ApoE-deficient mice 1.9- to 5.1-fold over lesions in saline-treated animals. These results suggest that under the appropriate circumstances changes in circulating proinflammatory cytokines and acute-phase proteins may be more than just markers of atherosclerosis but actual participants in early lesion development.
Immobilization and Characterization of L-Asparaginase over Carbon Xerogels (2022)

L-asparaginase (ASNase) is an aminohydrolase currently used in the pharmaceutical and food industries. Enzyme immobilization is an exciting option for both applications, allowing for a more straightforward recovery and increased stability. High surface area and customizable porosity make carbon xerogels (CXs) promising materials for ASNase immobilization. This work describes the influence of contact time, pH, and ASNase concentration on the immobilization yield (<i>IY</i>) and relative recovered activity (<i>RRA</i>) using the Central Composite Design methodology. The most promising results were obtained using CX with an average pore size of 4 nm (CX-4), reaching <i>IY</i> and <i>RRA</i> of 100%. At the optimal conditions (contact time 49 min, pH 6.73, and [ASNase] 0.26 mg·mL<sup>-1</sup>), the ASNase-CXs biocomposite was characterized and evaluated in terms of kinetic properties and operational, thermal, and pH stabilities. The immobilized ASNase onto CX-4 retained 71% of its original activity after six continuous reaction cycles, showed good thermal stability at 37 °C (<i>RRA</i> of 91% after 90 min), and was able to adapt to both acidic and alkaline environments. Finally, the results indicated a 3.9-fold increase in the immobilized ASNase affinity for the substrate, confirming the potential of CXs as a support for ASNase and as a cost-effective tool for subsequent use in the therapeutic and food sectors.
The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing (1990)

DNA from 161 patients with various forms of hematologic malignancies were investigated for mutations in exons 1 and 2 of the N-RAS, K-RAS and Ha-RAS gene by direct sequencing of DNA amplified in vitro by the polymerase chain reaction. Mutations involving either codons 11, 12, or 13 of the N-RAS gene were identified in 18 of the 161 patients. The relative frequencies of N-RAS gene mutations in these hematologic disorders was as follows: acute myelogenous leukemia (AML), 15%; acute lymphoblastic leukemia (ALL), 14%; myelodysplastic syndromes, 24%; and myeloid and lymphoid blast crisis of chronic myelogenous leukemia (CML), 3%. No correlation was observed between the presence of mutations and cytologic features or immunophenotype of these malignancies. Mutations involving codons 12 or 13 were equally prevalent, with a glycine to aspartic acid substitution being the most frequently encountered change. A single T-ALL case had a codon 11 mutation resulting in substitution of alanine with threonine. We failed to find mutations in exons 1 and 2 of the K-RAS or Ha-RAS genes in any case except a single AML with a mutation in codon 61 of the K-RAS gene. Also, no mutations were identified in chronic phase of CML, chronic lymphocytic leukemia. Ph1 positive ALL, non-Hodgkin's lymphoma, Hodgkin's disease, or multiple myeloma. These results indicate that RAS mutations, especially those involving exon 1 of the N-RAS gene, are frequent only in a subset of hematologic malignancies.
Embryonic development of axon pathways in the Drosophila CNS. I. A glial scaffold appears before the first growth cones (1989)

Three classes of glial cells are present early in embryogenesis and appear to play a major role in axon pathway formation in the Drosophila CNS. Six longitudinal glial (LG) cells are present over the longitudinal connective on each side of each segment. Six midline glia (MG) cells surround the anterior and posterior commissures of each segment. Finally, the intersegmental nerve root is covered by a glial cell: the segment boundary cell (SBC). All 3 classes of glial cells are present in their final position before axon outgrowth and their pattern prefigures the first axon pathways. The pioneer growth cones that establish the first axon pathways in the longitudinal connective and intersegmental nerve extend along the elongate surface of the LG and SBC glial cells; the pioneer growth cones for the anterior and posterior commissures extend toward and make close contact with the end feet of the MG glial cells. Later, all 3 classes of glial cells enwrap the axon tracts in much the same way as vertebrate oligodendrocytes. The results suggest that these early glial cells provide guidance cues for the first growth cones in the Drosophila CNS. More than simply providing a permissive substrate, the differential extension of specific early growth cones towards either the MG cells or along the LG cells suggests an active role for these glia in growth cone guidance.
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (1994)

Part 1 Anatomy and biology of bone matrix and cellular elements: anatomy and ultrastructure of bone bone morphogenesis and embryologic development bone formation - osteoblast lineage cells, growth factors, matrix proteins and the mineralization process bone remodelling biomechanics of bone. Part 2 Skeletal physiology: childhood and adolescence pregnancy and lactation menopause the aging skeleton. Part 3 Mineral homeostasis: the intestinal absorption of calcium, magnesium and phosphate calcium, magnesium and phosphorus - renal handling and urinary excretion mineral balance and homeostasis parathyroid hormone parathyroid hormone-related protein vitamin D - photobiology, metabolism, mechanism of action and clinical applications calcitonin gonadal steroids and receptors. Part 4 Clinical evaluation of bone and mineral disorders: history and physical examination blood calcium, phosphorus and magnesium assay methods - parathyroid hormone, parathyroid hormone-related protein and calcitonin vitamin D metabolites biochemical markers of bone turnover radiologic evaluation of bone mineral in children scintigraphy in metabolic bone disease clinical application of bone densitometry radiology of osteoporosis bone biopsy and histomorphometry in clinical practice molecular diagnosis of bone and mineral disorders. Part 5 Disorders of serum minerals: hypercalcaemia - pathogenesis, clinical manifestations, differential diagnosis and management primary hyperparathyroidism familial hyperparathyroid syndromes familial hypocalciuric hypercalcaemia tertiary hyperparathyroidism and refractory secondary hyperparathyroidism humoral hypercalcaemia of malignancy hypercalcaemia in haematologic malignancies and in solid tumors associated with extensive localized bone destruction hypercalcaemia due to granuloma-forming disorders miscellaneous causes of hypercalcaemia hypercalcaemic syndromes in infants and children hypocalcaemia - pathogenesis, differential diagnosis and management hypoparathyroidism parathyroid hormone resistance syndromes neonatal hypocalcaemia miscellaneous causes of hypocalcaemia magnesium depletion and hypermagnesemia hyperphosphatemia and hypophosphatemia. Part 6 Metabolic bone diseases: epidemiology of osteoporosis pathogenesis of postmenopausal osteoporosis physical activity and regulation of bone mass prevention of osteoporosis nutrition and osteoporosis evaluation of postmenopausal osteoporosis pharmacology of agents to treat osteoporosis pharmacologic treatment of postmenopausal osteoporosis osteoporosis in men glucocorticoid-induced osteoporosis transplantation osteoporosis juvenile osteoporosis secondary causes of osteoporosis - thyrotoxicosis and lack of weight bearing orthopaedic complications of osteoporosis osteoporosis and rheumatic diseases nutritional rickets and osteomalacia metabolic bone disease of total parental nutrition vitamin D-dependent rickets hypophosphatemic vitamin D-resi
Performance of Multicarrier Trellis-coded 8PSK Using Frequency Hopping in Rayleigh Fading Channels (1994)

A multicarrier trellis-coded 8PSK system using frequency hopping (FB) technique is proposed to improve bit error rate (BER) performance in digital land mobile communications. In general, trellis-coded modulation (TCM) system is employed with interleaving in multipath fading environment, whereas, in this system, we employ FB technique to disperse the influence of successively received weak signals due to multipath fading with small delay, i.e., without interleaving process. BER performance of the proposed system in a Rayleigh fading channel is investigated by computer simulation. It is shown that although there is no improvement in diversity order by applying FH technique, there is an improvement in energy efficiency as compared with a multicarrier trellis-coded 8PSK system without FH. It is also shown that the performance of the proposed system is not affected by the fade rate of the channels, i.e., the proposed system is effective even in the slow fading condition. Therefore, it is found that the proposed system is effective in the case that the processing delay time is restricted, such as mobile speech communications.