gebhart/patrepeval huggingface dataset:
Frames and Slants in Titles of Visualizations on Controversial Topics (2018)

Slanted framing in news article titles induce bias and influence recall. While recent studies found that viewers focus extensively on titles when reading visualizations, the impact of titles in visualization remains underexplored. We study frames in visualization titles, and how the slanted framing of titles and the viewer's pre-existing attitude impact recall, perception of bias, and change of attitude. When asked to compose visualization titles, people used five existing news frames, an open-ended frame, and a statistics frame. We found that the slant of the title influenced the perceived main message of a visualization, with viewers deriving opposing messages from the same visualization. The results did not show any significant effect on attitude change. We highlight the danger of subtle statistics frames and viewers' unwarranted conviction of the neutrality of visualizations. Finally, we present a design implication for the generation of visualization titles and one for the viewing of titles.
Touring Machine: a software platform for distributed multimedia applications (1992)

The goal of the Touring Machine project is to provide a reliable and extensible software platform that supports independently-developed distributed multimedia applications. The project includes an experimental testbed composed of a network of desktop video and audio devices controlled via user workstations. Touring Machine is more than a research testbed; it is the basis of the communications tools used daily by 100 users in two Bellcore locations 50 miles apart. It supports multimedia conferencing and information services as well as point-to-point communications. This paper describes Touring Machine, its system model and its software architecture. 1 Introduction With the technological advances in computing and communication networks in recent years, we have seen the emergence of a variety of distributed multimedia applications[7, 22]. Examples of such applications include Computer Supported Cooperative Work (CSCW)[11], medical applications[9], multimedia conferencing[19, 21], and dis...
Shot-based deghosting for variable sea surface and receiver depth (2017)

Uncertainties in the water velocity, receiver location and sea surface state introduce noise and ringing after deghosting. Therefore, a shot-based deghosting method is discussed that includes a constraint to reduce this effect of inaccuracies in the ghost model. First, we show results for a flat cable with an accurate ghost model. After that, the deghosting method is applied to a shot with a slanted cable. Finally, an inaccurate ghost model is applied to a shot, that is modelled with a variable sea surface. Presentation Date: Monday, September 25, 2017 Start Time: 4:45 PM Location: 360A Presentation Type: ORAL
The multi-protein family of Arabidopsis sulphotransferases and their relatives in other plant species (2004)

All members of the sulphotransferase (SOT, EC 2.8.2.-) protein family use 3'-phosphoadenosine 5'-phosphosulphate (PAPS) as the sulphuryl donor and transfer the sulphonate group to an appropriate hydroxyl group of several classes of substrates. These enzymes have highly conserved domains and can be found in eubacteria and eukaryotes. In mammals, sulphate conjugation catalysed by SOTs constitutes an important reaction in the transformation of xenobiotics, and in the modulation of the biological activity of steroid hormones and neurotransmitters. In plants, sulphate-conjugation reactions seem to play an important role in plant growth, development, and adaptation to stress. To date only a few plant SOTs have been characterized in detail. The flavonol 3- and 4'-SOTs from Flaveria species (Asteraceae), which catalyse the sulphonation of flavonol aglycones and flavonol 3-sulphates, respectively, were the first plant SOTs for which cDNA clones were isolated. The plasma membrane associated gallic acid SOT of Mimosa pudica L. pulvini cells may be intrinsic to signalling events that modify the seismonastic response. In Brassica napus L. a SOT catalyses the O-sulphonation of brassinosteroids and thereby abolishes specifically the biological activity of 24-epibrassinolide. The fully sequenced genome of Arabidopsis thaliana Heynh. contains in total 18 genes that are likely to encode SOT proteins based on sequence similarities of the translated products with an average identity of 51.1%. So far only one SOT from A. thaliana (At5g07000) was functionally characterized: the protein was shown to catalyse the sulphonation of 12-hydroxyjasmonate and thereby inactivate excess jasmonic acid in plants. The substrates and, therefore, the physiological roles of SOTs are very diverse. By using the numerous informative databases and methods available for the model plant A. thaliana, the elucidation of the functional role of the SOT protein family will be accelerated.
Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells. (1998)

Uptake of the dipeptide L-carnosine in primary cultured pigmented rabbit conjunctival epithelial cells is probably mediated by a proton-driven dipeptide transporter. This transporter may be used for optimizing the uptake of structurally similar peptidomimetic drugs.
Evaluation of Recombinant Leptospira Antigen-Based Enzyme-Linked Immunosorbent Assays for the Serodiagnosis of Leptospirosis (2001)

There is an urgent need for development of new serodiagnostic strategies for leptospirosis, an emerging zoonosis with worldwide distribution. We have evaluated the diagnostic utility of five recombinant antigens in enzyme-linked immunosorbent assays (ELISAs) for serodiagnosis of leptospirosis. Sera from 50 healthy residents of a high-incidence region were used to determine cutoff values for 96% specificity. In paired sera from 50 cases of leptospirosis confirmed by the microscopic agglutination test, immunoglobulin G (IgG) but not IgM reacted with the recombinant leptospiral proteins. The recombinant LipL32 IgG ELISA had the highest sensitivities in the acute (56%) and convalescent (94%) phases of leptospirosis. ELISAs based on recombinant OmpL1, LipL41, and Hsp58 had sensitivities of 16, 24, and 18% during the acute phase and 72, 44, and 32% during convalescence, respectively. Compared to sera from healthy individuals, patient sera did not react significantly with recombinant LipL36 (P > 0.05). Recombinant LipL32 IgG ELISA demonstrated 95% specificity among 100 healthy individuals, and specificities ranging from 90 to 97% among 30 dengue patients, 30 hepatitis patients, and 16 patients with diseases initially thought to be leptospirosis. Among 39 Venereal Disease Research Laboratory test-positive individuals and 30 Lyme disease patients, 13 and 23% of sera, respectively, reacted positively with the rLipL32 antigen. These findings indicate that rLipL32 may be an useful antigen for the serodiagnosis of leptospirosis.
Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma (2005)

Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type occur in a number of anatomic sites, but share overlapping morphologic and immunophenotypic features. Helicobacter pylori infection has been identified as an etiologic factor in gastric MALT lymphoma, and a growing list of other infectious organisms have recently been shown to be associated with MALT lymphomas at other anatomic sites. Although cause and effect has not been established for most of these infectious agents, our understanding of the biology has significantly improved, in part through the application of standard cytogenetic analyses. The common karyotypic alterations that characterize MALT lymphomas include the trisomies 3 and 18, the translocations t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(q27;q32), and the recently described t(3;14)(p14.1;q32). This apparent complexity of cytogenetic alterations that have now been implicated in the pathogenesis of extranodal MALT lymphoma serves as a paradigm for molecular cross talk in neoplastic disease. Recent data have shown that at least three of the disparate translocations affect a common signaling mechanism, and thus unify all three under a common pathogenesis, resulting in the constitutive activation of the nuclear factor kappa B (NF-kappaB) pathway. It may be that the new MALT-related translocation involving the FOXP1 gene and other as yet undiscovered translocations may all have in common increased NF-kappaB signaling.
Reliability Issues in Distributed Operating Systems (1987)

Distributed systems span a wide spectrum in the design space. In this paper we will look at the various kinds and discuss some of the reliability issues involved. In the first half of the paper we will concentrate on the causes of unreliability, illustrating these with some general solutions and examples. Among the issues treated are interprocess communication, machine crashes, server redundancy, and data integrity. In the second half of the paper, we will examine one distributed operating system, Amoeba, to see how reliability issues have been handled in at least one real system, and how the pieces fit together. 1. INTRODUCTION It is difficult to get two computer scientists to agree on what a distributed system is. Rather than attempt to formulate a watertight definition, which is probably impossible anyway, we will divide these systems into three broad categories: - Closely coupled systems - Loosely coupled systems - Barely coupled systems The key issue that distinguishes these syst...
Cationic facial amphiphiles: a promising class of transfection agents. (1996)

A promising class of compounds for DNA transfection have been designed by conjugating various polyamines to bile-acid-based amphiphiles. Formulations containing these compounds were tested for their ability to facilitate the uptake of a beta-galactosidase reporter plasmid into COS-7 cells. Dioleoyl phosphatidyl ethanolamine (DOPE) formulations of some of the compounds were several times better than Lipofectin at promoting DNA uptake. The most active compounds contained the most hydrophilic bile acid components. The activity is clearly not related to affinity for DNA: the hydrophobic bile acid conjugates were found to form stable complexes with DNA at lower charge ratios than the hydrophilic conjugates. We suggest that the high activity of the best compounds is related to their facial amphiphilicity, which may confer an ability to destabilize membranes. The success of these unusual cationic transfection agents may inspire the design of even more effective gene delivery agents.
Derivation of induced pluripotent stem cells from pig somatic cells (2009)

For reasons that are unclear the production of embryonic stem cells from ungulates has proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, hOCT4, hSOX2, hKLF4, and hc-MYC, the combination commonly used to create iPSC in mouse and human. Cells were cultured on irradiated mouse embryonic fibroblasts (MEF) and in medium supplemented with knockout serum replacement and FGF2. Compact colonies of alkaline phosphatase-positive cells emerged after approximately 22 days, providing an overall reprogramming efficiency of approximately 0.1%. The cells expressed porcine OCT4, NANOG, and SOX2 and had high telomerase activity, but also continued to express the 4 human transgenes. Unlike human ESC, the porcine iPSC (piPSC) were positive for SSEA-1, but negative for SSEA-3 and -4. Transcriptional profiling on Affymetrix (porcine) microarrays and real time RT-PCR supported the conclusion that reprogramming to pluripotency was complete. One cell line, ID6, had a normal karyotype, a cell doubling time of approximately 17 h, and has been maintained through >220 doublings. The ID6 line formed embryoid bodies, expressing genes representing all 3 germ layers when cultured under differentiating conditions, and teratomas containing tissues of ectoderm, mesoderm, and endoderm origin in nude mice. We conclude that porcine somatic cells can be reprogrammed to form piPSC. Such cell lines derived from individual animals could provide a means for testing the safety and efficacy of stem cell-derived tissue grafts when returned to the same pigs at a later age.
The Unique Cyanobacterial Protein OpcA Is an Allosteric Effector of Glucose-6-phosphate Dehydrogenase in Nostoc punctiformeATCC 29133 (2001)

Glucose-6-phosphate dehydrogenase (G6PD), encoded by zwf, is essential for nitrogen fixation and dark heterotrophic growth of the cyanobacterium Nostoc punctiforme ATCC 29133. In N. punctiforme, zwf is part of a four-gene operon transcribed in the order fbp-tal-zwf-opcA. Genetic analyses indicated that opcA is required for G6PD activity. To define the role of opcA, the synthesis, aggregation state, and activity of G6PD in N. punctiforme strains expressing different amounts of G6PD and/or OpcA were examined. A single tetrameric form of G6PD was consistently observed for all strains, as well as for recombinant N. punctiforme His-G6PD purified from Escherichia coli, regardless of the quantity of OpcA present. However, His-G6PD and the G6PD of strain UCD 351, which lacks OpcA, had low affinities for glucose 6-phosphate (G6P) substrate (K(m)(app) = 65 and 85 mm, respectively) relative to wild-type N. punctiforme G6PD (K(m)(app) = 0.5 mm). Near wild-type affinities for G6P were observed for these enzymes when saturating amounts of His-OpcA- or OpcA-containing extract were added. Kinetic studies were consistent with OpcA acting as an allosteric activator of G6PD. A role in redox modulation of G6PD activity was also indicated, because thioredoxin-mediated inactivation and reactivation of His-G6PD occurred only when His-OpcA was present.
Synthese und Strukturuntersuchung des Poly(1‐hydroxytetramethylen)s (1977)

Abstract Poly(1‐hydroxytetramethylene) was prepared via hydroboration of cis ‐1,4‐poly(butadiene). The structure of the polymer chain generated by a random hydroxylation of the carbon double bonds of the butadien units was determined by 13 C NMR spectroscopy.
Active transmission line: light amplification by backward-stimulated Raman scattering in polarization-maintaining optical fiber (1984)

The possibility of an active transmission line with a polarization-maintaining optical fiber has been investigated by means of backward-stimulated Raman gain. The fourth Stokes line of the stimulated Raman scattering is placed near 1.3 μm with pumping light of 1.06-μm wavelength, in which Raman gain at 1.30 μm is produced in terms of a strong pump that is due to the third Stokes line at 1.24 μm. A laser diode (InGaAsP/InP) operating at 1.30 μm is used as signal light to meet the Raman gain. As a result, a Raman gain as high as 20 dB and a gain coefficient of 2.0 × 10−12 cm/W have been obtained. It is shown experimentally that it is important to meet exactly the polarization directions between the pump and the signal pulses to obtain a large Raman gain.
Is CO 2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO 2 Concentrations on Human Decision-Making Performance (2012)

Direct adverse effects of CO2 on human performance may be economically important and may limit energy-saving reductions in outdoor air ventilation per person in buildings. Confirmation of these findings is needed.
Safety of inhaled corticosteroids. (1982)

Corticosteroids effectively suppress asthma but have unwanted systemic side-effects which can be avoided if taken by inhalation. Inhaled corticosteroids are effective and although sensitive tests can occasionally detect some systemic activity with a daily dose of beclomethasone diproprionate of 400--800 micrograms, in clinical practice systemic side-effects are not seen. If this daily dose is raised above 1.5--2.0 mg systemic activity is more easily detected and is more likely to be of clinical significance. Local side-effects include occasional hoarseness and oropharyngeal thrush. There have been no reports of opportunistic pulmonary infections or bronchial epithelial damage following prolonged use. Inhaled corticosteroids are now in widespread us in over 100 countries throughout the world. They have also been employed for nearly a decade and this extensive clinical experience has not revealed significant systemic side-effects. This safety compares favourably with other asthma treatment and suggests that inhaled corticosteroids may be used when bronchodilators are failing to control symptoms and higher doses are thought necessary or being taken. Better asthma control should reduce bronchodilator consumption and the net incidence of side-effects. Inhaled corticosteroids can therefore safely provide effective treatment and steer a path between the risk of intensive bronchodilator treatment and those produced by systemic steroids.
Mutations of the CD40 Ligand Gene and Its Effect on CD40 Ligand Expression in Patients With X-Linked Hyper IgM Syndrome (1998)

X-linked hyper IgM syndrome (XHIM) is a primary immunodeficiency disorder caused by mutations of the gene encoding CD40 ligand (CD40L). We correlated mutations of the CD40L gene, CD40L expression, and the clinical manifestations observed in XHIM patients from 30 families. The 28 unique mutations identified included 9 missense, 5 nonsense, 9 splice site mutations, and 5 deletions/insertions. In 4 of 9 splice site mutations, normally spliced and mutated mRNA transcripts were simultaneously expressed. RNase protection assay demonstrated that 5 of 17 mutations tested resulted in decreased levels of transcript. The effect of the mutations on CD40L expression by activated peripheral blood mononuclear cells (PBMC) and T-cell lines or clones was assessed using one polyclonal and four monoclonal antibodies and a CD40-Ig fusion protein. In most patients, the binding of at least one antibody but not of CD40-Ig was observed, suggesting nonfunctional CD40L. However, activated PBMC from three patients and activated T-cell lines from two additional patients, each with different genotype, bound CD40-Ig at low intensity, suggesting functional CD40L. Thus, failure of activated PBMC to bind CD40-Ig is not an absolute diagnostic hallmark of XHIM and molecular analysis of the CD40L gene may be required for the correct diagnosis. Patients with genotypes resulting in diminished expression of wild-type CD40L or mutant CD40L that can still bind CD40-Ig appear to have milder clinical consequences.
Substitution of Milk for Serum in the Production of Human Leukocyte Interferon (1971)

The presence of serum in suspensions of Sendai-induced human leukocytes is necessary for the synthesis of significant amounts of interferon. Very little interferon is obtained from serum-free suspensions. Cow's milk or milk casein can substitute for serum in the production of high yields of human leukocyte interferon.
Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models. (2003)

These results suggest that inhibition of c-myc proto-oncogene by GD(2)-targeted antisense therapy could provide an effective approach for the treatment of melanoma in an adjuvant setting.
Cover Picture: Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006) (2006)

Qing hao su , or artemisinin, is the active compound isolated from the herb Artemisia annua (qīng hāo) shown in the cover picture. The Chinese text shown describing its use in Chinese medicine dates back to 340 AD. Derivatives of artemisinin are currently used for the treatment of malaria. In their Communication on page 2082 ff., R. K. Haynes et al. describe the preparation and superior efficacy of the new derivative artemisone against the malaria parasite. (Chinese text verified by Prof. Chun‐Tao Che.)
Synergistic Induction of Anchorage-independent Growth of NIH3T3 Mouse Fibroblasts by Cysteine Proteinase Inhibitors and a Tumor Promoter (1996)

We have previously reported that Ras protein is a potent cysteine proteinase inhibitor. In order to examine whether the cysteine proteinase-inhibitory activity of Ras is involved in carcinogenesis, the effects of the following probes were investigated. Cystatin alpha is a cysteine proteinase-specific inhibitor and has some amino acid sequence homology with Ras. Ras has a CAAX motif (C, cysteine; A, aliphatic amino acid; X, any amino acid) at the carboxyl terminus, which is indispensable for the biological activity. Thus, cystatin alpha carrying a CAAX motif (cystatin alpha-CVLS) was examined. A v-Ha-Ras deletion mutant, Ras delta 42-49, has undetectable GTP binding activity, yet it retains a similar protease inhibitory activity to that of wild-type v-Ras. These genes were inserted into a eukaryotic inducible expression vector and transfected into NIH3T3 cells. The expression was effectively induced by treatment with a glucocorticoid hormone, dexamethasone. The expression of cystatin alpha-CVLS or Ras delta 42-49 alone induced neither transformation nor morphological changes. However, when their expression was induced in the presence of a tumor-promoting phorbol ester, a remarkable increase in the anchorage-independent growth was observed in cystatin alpha-CVLS- and Ras delta 42-49-transfected clones. These results suggest that cysteine proteinase inhibitors and a tumor promoter synergistically transformed NIH3T3 cells. It is thus possible that the cysteine proteinase-inhibitory activity of Ras might play a key role in the early stage of carcinogenesis.
L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways (2011)

We recently reported that apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor growth and improve survival in a mouse model of ovarian cancer. The current study was designed to examine whether inhibition of angiogenesis is one of the mechanisms for the observed anti-tumorigenic effects. The apoA-I mimetic peptide L-5F had no affect on proliferation and cell viability of human umbilical vascular endothelial cells (HUVECs) in the basal state; however, treatment with L-5F at 1, 3, and 10 μg ml(-1), dose-dependently inhibited both vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced proliferation, cell viability, migration, invasion and tube formation in HUVECs. L-5F inhibited VEGF- and bFGF-induced activation of their corresponding receptors, VEGFR2 and FGFR1, as well as downstream signaling pathways, including Akt and ERK1/2. MicroCT scanning and immunohistochemistry staining demonstrated that daily injection of L-5F (10 mg kg(-1)) decreased both the quantity and size of tumor vessels in mice. L-5F treated mice showed significantly reduced levels of VEGF in both tumor tissue and the circulation, which is consistent with in vitro data showing that L-5F inhibited production and secretion of VEGF from mouse and human ovarian cell lines in the absence and presence of exogenously added lysophosphatidic acid, a potent tumor promoter. In conclusion, our data that L-5F inhibits angiogenesis suggests that apoA-I mimetic peptides may serve as novel anti-angiogenesis agents for the treatment of angiogenesis-associated diseases, including cancer.