gebhart/patrepeval huggingface dataset:
Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells (2015)

Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients. Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration of SKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovarian cancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression. The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic and therapeutic target for ovarian cancer.
Assessment of Capsiconinoid Composition, Nonpungent Capsaicinoid Analogues, in Capsicum Cultivars (2009)

Capsiconinoid is a group of nonpungent capsaicinoid analogues produced in Capsicum fruits, which we recently identified. Capsiconinoids have agonist activity for transient receptor potential vanilloid type 1 (TRPV1), which is reported to be a receptor for capsaicin. It is, therefore, important to screen cultivars containing high levels of capsiconinoid for their use as a vegetable or dietary supplement. This study describes the quantitative analysis of capsiconinoid content in fruits of 35 Capsicum cultivars: 18 cultivars of C. annuum, 7 of C. baccatum, 5 of C. chinense, 4 of C. frutescens, and 1 of C. pubescens. Using high-performance liquid chromatography (HPLC), we found that 10 cultivars contained capsiconinoids. Capsiconinoid Baccatum (CCB) (C. baccatum var. praetermissum) showed the highest capsiconinoid content (3314 microg/g DW) and Charapita (C. chinense) had the second highest content. The other 8 cultivars had much lower capsiconinoid content than these two cultivars (<300 microg/g DW). Time-course analysis during fruit development clarified that capsiconinoid content in CCB fruits increased until 30 days after flowering (DAF) and then decreased rapidly until 40 DAF.
A knowledge-based software information system (1989)

The difficulty of maintaining very large software systems is becoming more widely acknowledged. One of the primary problems is the need to access information about a complex and evolving system. We are exploring the contribution to be made by applying explicit knowledge representation and reasoning to the management of information about large systems. LaSSIE is a prototype tool (based on the ARGON system) that uses a frame-based description language and classification inferences to facilitate a programmer's discovery of the structure of a complex system. It also supports the retrieval of software for possible re-use in a new development task. Among LaSSIE's features are an integrated natural language front-end (TELI) that allows users to express requests in an informal and compact fashion. Although not without some limitations, LaSSIE represents significant progress over existing software retrieval methods and strictly bottom-up cross-referencing facilities.
Technical considerations in longitudinal multispectral small animal molecular imaging (2007)

In a previous study, we investigated physical methods to reduce whole-body, diet-related autofluorescence interference in several mouse strains through changes in animal diet. Measurements of mice with an in vivo multispectral imaging system over a 21-day period allowed for the quantification of concentration changes in multiple in vivo fluorophores. To be an effective instrument, a multispectral imaging system requires a priori spectral knowledge, the form and importance of which is not necessarily intuitive, particularly when noninvasive in vivo longitudinal imaging studies are performed. Using an optimized spectral library from a previous autofluorescence-reduction study as a model, we investigated two additional spectral definition techniques to illustrate the results of poor spectral definition in a longitudinal fluorescence imaging study. Here we systematically evaluate these results and show how poor spectral definition can lead to physiologically irrelevant results. This study concludes that the proper selection of robust spectra corresponding to each specific fluorescent molecular label of interest is of integral importance to enable effective use of multispectral imaging techniques in longitudinal fluorescence studies.
Placental transfer of immunoglobulin G subclasses (1994)

The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B.
基因、发育和癌爱德华·B·刘易斯的生活与工作 (2006)

爱德华·B·刘易斯（Edward B．Lewis）因在遗传学和发育生物学方面的贡献而闻名世界，此外，他在电离辐射与癌症关系的研究方面也走在前列。但由于种种原因他的论文很少有人拜读过。本书由与刘易斯共事20年的Howard Lipshitz编辑出版，书中收集了刘易斯在遗传、发育生物学和辐射与癌症关系三方面的重要文章，将他在这三方面发表的重要论文结集出版是第一次。
A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia (2014)

At 52 weeks, evolocumab added to diet alone, to low-dose atorvastatin, or to high-dose atorvastatin with or without ezetimibe significantly reduced LDL cholesterol levels in patients with a range of cardiovascular risks. (Funded by Amgen; DESCARTES ClinicalTrials.gov number, NCT01516879.).
Isolation process dependence of channel mobility in thin-film SOI devices (1996)

Degradation of NMOS and enhancement of PMOS I-V characteristics are found to be dependent on specific isolation processes in thin-film SOI devices. These variations are due to mobility decrease in NMOS and increase in PMOS, which can be attributed to the isolation-process-related compressive strain of the silicon film. Magnitudes of mobility variation as high as 40% are observed in the affected SOI devices.
SPARC: a potential diagnostic marker of invasive meningiomas. (1999)

SPARC, a secreted, extracellular matrix-associated protein implicated in the modulation of cell adhesion and migration, was evaluated as a marker for invasive meningiomas. Although the majority of meningiomas are clinically and morphologically benign, approximately 10% progress into atypical and malignant tumors, according to the standard criteria. However, a subset of meningiomas presents as histomorphologically benign tumors (WHO grade I), but they are clinically invasive. It has been suggested that these tumors should be classified as malignant, and that the patients may require adjuvant therapy and closer follow up. Unfortunately, a significant number of these tumors may not be recognized because the surgical specimen used to assess the grade of a tumor lacks the infiltrative interface with the brain, which is currently necessary to determine its invasive character. Therefore, a marker of heightened invasiveness would greatly facilitate the identification of this subset of patients. In this study, the immunohistochemical expression of SPARC in benign, noninvasive primary meningiomas was compared with its expression in invasive, aggressive, primary and recurrent meningiomas. SPARC was not expressed in the 9 benign, noninvasive tumors, but was highly expressed in the 20 invasive tumors, regardless of the grade. The findings suggest that SPARC is a potential diagnostic marker of invasive meningiomas and is capable of distinguishing the histomorphologically benign noninvasive from the histomorphologically benign but invasive meningiomas, in the absence of the infiltrative interface.
Effects of Combining Propofol and Alfentanil on Ventilation, Analgesia, Sedation, and Emesis in Human Volunteers (1996)

The combination of propofol and alfentanil produced greater sedation and analgesia than that with either drug alone. Propofol offset the emetic effects of alfentanil. Equivalent depression of the carbon dioxide response curve, and elevation of end-tidal carbon dioxide occurred with propofol/alfentanil combined and alfentanil.
Epidermal growth factor receptor expression in neurofibromatosis type 1–related tumors and NF1 animal models (2000)

We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack EGF-R and respond to ligands other than EGF. Nevertheless, immunoblotting, Northern analysis, and immunohistochemistry revealed that each of 3 malignant peripheral nerve sheath tumor (MPNST) cell lines from NF1 patients expressed the EGF-R, as did 7 of 7 other primary MPNSTs, a non-NF1 MPNST cell line, and the S100(+) cells from each of 9 benign neurofibromas. Furthermore, transformed derivatives of Schwann cells from NF1(-/-) mouse embryos also expressed the EGF-R. All of the cells or cell lines expressing EGF-R responded to EGF by activation of downstream signaling pathways. Thus, EGF-R expression may play an important role in NF1 tumorigenesis and Schwann cell transformation. Consistent with this hypothesis, growth of NF1 MPNST lines and the transformed NF1(-/-) mouse embryo Schwann cells was greatly stimulated by EGF in vitro and could be blocked by agents that antagonize EGF-R function.
Robust real-time lane and road detection in critical shadow conditions (2002)

This paper presents the vision-based road detection system currently installed onto the MOB-LAB land vehicle. Based on a geometrical transform and on a fast morphological processing, the system is capable to detect road markings even in extremely severe shadow allows to achieve a processing rate of about 17 Hz.
Chimeric extracellular domain of type II transforming growth factor (TGF)‐β receptor fused to the Fc region of human immunoglobulin as a TGF‐β antagonist (1998)

Transforming growth factor-beta (TGF-beta) type-I and type-II receptors form a ligand-dependent heteromeric signalling complexes, in which transforming growth factor-beta receptor type II (TbetaRII) trends to act as the primary receptor. In the present study, we used a chimeric soluble type-II receptor fused with the Fc regions of human immunoglobulin (TbetaRIIs-Fc) in order to obtain a putative TGF-beta antagonist. Biochemical studies revealed that TbetaRIIs-Fc shared the same properties as the wild-type receptor. The TbetaRIIs-Fc receptor displayed an affinity of 1370 +/- 363 pM which was similar to those of the wild-type TbetaRII when expressed alone in Cos-1 cells (1122 +/- 413 pM). Furthermore, the chimeric receptor showed the same selectivity for TGF-beta isoforms as the native receptor. Although both TGF-beta1 and TGF-beta3 were able to bind TbetaBRIIs-Fc, TGF-beta2 could not compete with the binding of TGF-beta1 to TbetaRIIs-Fc. It was noted that this type of fused Fc receptor could be used in FlashPlate screening for potent agonism and antagonism of TGFbeta. Moreover, biological activities of the chimeric receptor showed it to be a potent TGF-beta1-antiproliferative and TGF-beta1-extracellular matrix transcriptional inhibitor on responses in Mv1Lu cells. To conclude, our results clearly show that the TbetaRIIs-Fc chimeric receptor could be used as a potent TGF-beta antagonist. These data raised the possibility that this TbetaRIIs-Fc construct might act successfully as an antagonist of both TGF-beta1 and TGF-beta3 in vivo.
Simple measurement of fiber dispersion and of chirp parameter of intensity modulated light emitter (1993)

We report a novel method to measure two important parameters for optical fiber intensity modulated transmission systems: dispersion of optical fibers and chirp parameter of modulated light emitters. The method is easy, quick, and accurate for chirp parameter in the -10-to-10 range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Gene Therapy for Neurologic Disease (1993)

Gene therapy is a potentially potent new method of treating a number of neurologic disorders previously considered refractory to current conventional therapeutic treatments. Numerous advances have been made in the construction of expression vectors, cellular and viral transgene carriers, and the characterization of target cells for neuronal gene therapy. Two primary approaches to nervous system gene transfer have emerged as a result of these advances. The in vivo approach concentrates on direct transfer of genetic material to cells in vivo using viral and chemical agents. The ex vivo approach relies on genetic transfer to cultured cells that are subsequently implanted into a host organism. Both of these methods have been used in preliminary experiments designed to test the efficacy of gene transfer strategies in the amelioration of nervous system dysfunction.
A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. (1986)

A recombinant 64 kD protein of Mycobacterium bovis bacillus Calmette-Guerin (BCG) (antigen A), which amounted to approximately 2% of an E. coli lysate, was tested for its capacity to stimulate human T4 clones reactive to mycobacterial proteins. Two out of four crossreactive clones, established from a patient with tuberculoid leprosy, which could be stimulated by protein preparations of M. leprae and M. tuberculosis, and by particulate M. bovis BCG were also reactive to antigen A without further enrichment from E. coli lysate. In addition, BCG-reactive T cell clones from two of three healthy PPD+ donors reacted with antigen A. This finding shows that human T cell clones may be useful for probing gene-cloned proteins of potential value for vaccination against diseases where protection is mediated exclusively by T cells.
Effects of Intensive Glucose Lowering in Type 2 Diabetes (2008)

As compared with standard therapy, the use of intensive therapy to target normal glycated hemoglobin levels for 3.5 years increased mortality and did not significantly reduce major cardiovascular events. These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)
Abstraction models at system level for networked interactive multimedia scripting (1995)

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.
Building the immunological synapse-toward a quantitative view of T cell activation (2003)

T cell activation requires formation of a specialized cell-cell junction, the immunological synapse (Paul and Seder, 1994). The authors have hypothesized that segregation will be an important process for T cell activation (Shaw and Dustin, 1997). To test these hypotheses and to explore the engineering principles behind these events the authors have developed a model system in which formation of an immunological synapse is quantitatively visualized in real time. Molecular segregation of engaged MHC-peptide and ICAM-1 complexes was strongly correlated with T cell proliferation. These data support the hypothesis that molecular segregation is important for T cell signaling.
Formation of free-standing carbon nanotube array on super-aligned carbon nanotube film and its field emission properties (2012)

Flexible and free-standing well-aligned carbon nanotube arrays have been synthesized on super-aligned carbon nanotube films. The combined structure of the carbon nanotube array and carbon nanotube film was formed during chemical vapor deposition on a quartz substrate which had previously been covered with a super-aligned carbon nanotube film. It was found that the growing carbon nanotube array could support up the super-aligned carbon nanotube film entirely, and the top of the array became densely entangled with the super-aligned carbon nanotube film. The carbon nanotube array with the super-aligned carbon nanotube film could be easily peeled off from the quartz substrate as a whole, giving a flexible and free-standing structure with good mechanical properties. The bottom of the array was also exposed after being peeled off and was used as a field emitter. The combined structure of the carbon nanotube array with the carbon nanotube film allowed adsorbent-free field emission by passing a heating current through it. Furthermore, due to the fast thermal response of the structure and the long time needed for re-adsorption of adsorbates in vacuum, it was found that pulsed heating with a 10% duty ratio was sufficient for adsorbent-free field emission. The heating power necessary to sustain the adsorbent-free state can be lowered in this way.
LIQUID CRYSTAL MATERIALS AND APPLICATIONS FOR THE NEXT GENERATION OF MICRODISPLAYS (2003)

Ferroelectric liquid crystal (FLC) liquid crystal over silicon (LCOS) devices can address large arrays of pixels at very high frame rates. They can also allow the phase of the light to be modulated in a manner that is independent of the state of polarisation of the incoming light. The optical versatility of the liquid crystal can now be matched by the electronic versatility of CMOS (complimentary metal oxide semiconductor) silicon backplanes as developments in very small feature sizes (sub micron) allows more and more complex electronic structures to be integrated into the device. In this paper, we briefly review some possible future applications of this technology in the area of displays, image processing and optical switching. In order to create these new device structures, we need suitable FLC materials.
Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study (2009)

Compared with ovarian conservation, bilateral oophorectomy at the time of hysterectomy for benign disease is associated with a decreased risk of breast and ovarian cancer but an increased risk of all-cause mortality, fatal and nonfatal coronary heart disease, and lung cancer. In no analysis or age group was oophorectomy associated with increased survival.
Comparison of Energy Cost and Gait Efficiency During Ambulation in Below-Knee Amputees Using Different Prosthetic Feet???A Preliminary Report (1988)

Nielsen, David H. L.P.T., Ph.D.; Shurr, Donald G. L.P.T., CO.; Golden, Jane C. L.P.T., M.S.; Meier, Kenneth C.P. Author Information
Targeting the complement system (1999)

Interest has blossomed in the development of complement inhibitors, in parallel with a growth in our understanding of the biology of the complement cascade. The first generation of designed inhibitors was based on naturally occurring complement receptors and regulatory molecules. These agents provided useful tools for exploring the role of complement in experimental models of disease, but may have limited therapeutic application in humans because of their short half-lives, limited bioavailability and possible antigenicity. More recently, humanized antibodies and synthetic molecules that block the activation of complement have been developed, which look as though they may overcome some of these difficulties. The possibility for precision inhibition of a limited part of the complement cascade, or for inhibition confined to a single organ, may offer effective therapeutic results, while avoiding the disadvantages of nonselective complement blockade. This review examines the recent evidence that complement inhibition will reduce tissue damage resulting from organ transplantation, ischaemia-reperfusion injury, cancer, glomerulonephritis and the use of extracorporeal circuits.
Precision time domain reflectometry in optical fiber systems using a frequency modulated continuous wave ranging technique (1985)

This paper describes a novel optical time domain reflectometer which uses a frequency-modulated single-mode semiconductor laser as the optical source. The new system offers a potential distance resolution of the order of 1 mm over ranges limited by the source linewidth. In this paper, a theoretical assessment of the features which determine the available performance of the system is followed by some experimental results which confirm these general trends. Applications of this system include short range fault location in situations where resolution of the order of centimeters is required, and as a novel discrimination technique for optical sensor multiplexing systems.
A micromachined elastomeric tip array for contact printing with variable dot size and density (2007)

We report a flexible and versatile microcontact printing process using a micromachined elastomeric PDMS (poly-dimethylsiloxane) stamp with two-dimensional arrays of pyramidal tips. The PDMS stamp was molded from a bulk-etched single-crystalline silicon master. By changing the contact pressure, arrayed dot patterns with different dot sizes (from submicron to a few microns) were obtained controllably with one single PDMS stamp. Variable density of dot patterns was also achieved in a 'step-print' manner by conducting multiple printing on a transitional stage. This technique is expected to be useful in many nano- and biotechnology applications, including single cell and neuron studies.
Rig Computer System Improves Safety for Deep HP/HT Wells by Kick Detection and Well Control Monitoring (1991)

ABSTRACT A drilling contractor has installed and operated on several offshore rigs, a comprehensive data acquisition and computer processing system for realtime monitoring of drilling operations and post event analysis. The system, which includes "smart alarms" for early warning of problems such as kicks, stuck pipe and drillstring washouts, has been extended to cover recent recommendations of the UK Department of Energy for High Pressure/High Temperature (HP/HT) wells. In this paper we describe the extensions to the system, developed with a major operator, which continuously monitor the return line valve status, mud pumps, choke manifold and BOP stack to ensure that all components are operating within their design limits. Although the smart alarms for early kick detection reduce the size of an influx, the problem of circulating out a kick remains a hazardous procedure requiring close monitoring. The system's existing realtime displays of log and digital data include a dedicated screen for well control to provide the necessary monitoring. Additional HP/HT monitors, which continuously display choke position, BOP terrperatures and separator pressures as required for the North Sea, have been added. Hard copies for detailed analysis are produced from a workstation linked to the network. The development and operation of this system are discussed, and the benefits in terms of improved safety and environmental protection are demonstrated.