gebhart/patrepeval huggingface dataset:
[Application of chest CT scan in gestational trophoblastic neoplasia with lung metastasis]. (2018)

<b>Objective:</b> To explore the role of CT scan for the diagnosis of lung metastasis in stage Ⅲ gestational trophoblastic neoplasia (GTN) . <b>Methods:</b> To figure out the role of CT scan for lung metastasis in GTN initial diagnosis, treatment and follow-up, 93 GTN patients with lung metastasis from January, 2015 to December, 2016 were retrospectively analyzed in Obstetrics and Gynecology Hospital of Fudan University. <b>Results:</b> (1) Among 93 GTN patients with lung metastasis, 70 patients with the International Federation of Gynecology and Obstetrics (FIGO) score ≤6 were defined as low risk GTN and 23 patients score score ≥7 were defined as high risk GTN. Forty nine patients had negative chest X-ray findings and 39 cases with pulmonary lesions were identified both by chest X-ray compared to CT scan. Five cases were excluded due to no consensus could make for the results of chest X-ray. The true positive rate of chest X-ray for lung metastasis were 41% (29/70) in low risk GTN and 43% (10/23) in high risk GTN patients without statistical difference (χ(2)=0.090, <i>P=</i>0.925) . For those patients with positive chest CT scan and negative chest X-ray finding, pulmonary lesions in 32 (65%, 32/49) cases were blocked by heart, chest wall or diaphragm in chest X-ray. Seventeen (35%,17/49) patients with lung lesions less than 5 mm had negative chest X-ray results due to the lower sensitivity compared to CT scan. (2) In 88 patients with stage Ⅲ, 78 patients had successful initial treatment, but 4 of them were recurrence in twelve months follow-up. Ten patients were chemotherapy resistance for the initial treatment. The initial chemotherapy remission rate in low risk GTN patients was higher than that in high risk ones (χ(2)=4.911, <i>P=</i>0.027) . In 49 cases with negative chest X-ray, there was no correlation with the rate of remission,chemotherapy resistance and recurrence in stage Ⅲ patients (<i>P></i>0.05) . (3) For those patients who had poorly response to initial chemotherapy, the diameters of lesions in lung were unchanged or increased during the treatment, form (5.1±4.1) mm to (7.4±2.8) mm. The pulmonary lesions were continuously shrunk from (7.8±5.3) mm to (4.7±4.4) mm for those patients with complete and partial remission including the recurrent GTN patients (<i>Z=-</i>2.713, <i>P=</i>0.007) . <b>Conclusions:</b> Patients with GTN in stage Ⅲ have down staging if only use chest X-ray for imaging at the initial diagnosis. Chest CT scan is recommended for primary imaging evaluation of FIGO staging in qualified medical organization. For those patients with persistent abnormal serum hCG level and negative chest X-ray, chest CT scan is strongly recommended to identify the persist or resistant lung lesions and follow up.
Mifepristone as Treatment of Recurrent Progesterone Receptor–Positive Uterine Leiomyosarcoma (2007)

We speculate that mifepristone has a role in the management of some cases of recurrent uterine leiomyosarcomas.
Graph based retargetable microcode compilation in the MIMOLA design system (1987)

This paper describes a retargetable compiler, which is able to compile programs into the machine code of a specified hardware (target). The target is described at register-transfer structure level by module specifications and netlists. The program can be defined at several levels of abstraction, spanning the range from algorithmic description (e.g. PASCAL) down to RT-level behavioural description. If the program is the complete target's behavioural specification the compiler can be used to verify the structural against this behavioural description.
Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells (2012)

Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with bromodomain-containing protein 4 (BRD4). We used genome-wide chromatin immunoprecipitation sequencing in primary human CD4+ T cells to reveal that BRD4 co-localizes with Ser-2-phosphorylated Pol II (Pol II Ser-2) at both enhancers and promoters of active genes. Disruption of bromodomain-histone acetylation interactions by JQ1, a small-molecule bromodomain inhibitor, resulted in decreased BRD4 binding, reduced Pol II Ser-2, and reduced expression of lineage-specific genes in primary human CD4+ T cells. A large number of JQ1-disrupted BRD4 binding regions exhibited diacetylated H4 (lysine 5 and -8) and H3K27 acetylation (H3K27ac), which correlated with the presence of histone acetyltransferases and deacetylases. Genes associated with BRD4/H3K27ac co-occupancy exhibited significantly higher activity than those associated with H3K27ac or BRD4 binding alone. Comparison of BRD4 binding in T cells and in human embryonic stem cells revealed that enhancer BRD4 binding sites were predominantly lineage-specific. Our findings suggest that BRD4-driven Pol II phosphorylation at serine 2 plays an important role in regulating lineage-specific gene transcription in human CD4+ T cells.
Coherent optical systems implemented for business traffic routing and access: the RACE COBRA project (1996)

The RACE COBRA consortium has performed four field trials to verify the suitability of dense WDM combined with heterodyne detection (for which the term CMC, "coherent multicarrier" is used) for different network applications. The main advantage in using heterodyne detection is the simple access to individual optical channels by only switching local lasers to the desired channel. Heterodyne detection acts as a perfect optical filter. Thus, a plurality of dense spaced optical carriers can be placed, e.g., within one WDM window. The additional freedom in the channel multiplex provides some advantages which are shown in the demonstrators: a routing flexibility in the RENO (reconfigurable node) cross-connect demonstrator supporting STM-16 at Philips Research in Eindhoven. A routing flexibility in the demonstrator at BBC in Kingswood Warren, UK, supporting uncompressed HDTV communication in a studio environment. By shifting switching functions to the terminals, the network is kept completely passive. This is also obtained in the local area videoconference trial at CET in Aveiro, Portugal, using high quality standard TV and in the BCPN trial at KPN Research in Leidschendam, NL, where ATM-streams are supported for multimedia services. The paper outlines the demonstrator concepts as well as some subsystems and key components developed by the consortium.
Parallel SQL execution in Oracle 10g (2004)

This paper describes the new architecture and optimizations for parallel SQL execution in the Oracle 10g database. Based on the fundamental shared-disk architecture underpinning Oracle's parallel SQL execution engine since Oracle7, we show in this paper how Oracle's engine responds to the challenges of performing in new grid-computing environments. This is made possible by using advanced optimization techniques, which enable Oracle to exploit data and system architecture dynamically without being constrained by them. We show how we have evolved and re-architected our engine in Oracle 10g to make it more efficient and manageable by using a single global parallel plan model.
The Human Immunodeficiency Virus Type 1gagGene Encodes an Internal Ribosome Entry Site (2001)

Several retroviruses have recently been shown to promote translation of their gag gene products by internal ribosome entry. In this report, we show that mRNAs containing the human immunodeficiency virus type 1 (HIV-1) gag open reading frame (ORF) exhibit internal ribosome entry site (IRES) activity that can promote translational initiation of Pr55(gag). Remarkably, this IRES activity is driven by sequences within the gag ORF itself and is not dependent on the native gag 5'-untranslated region (UTR). This cap-independent mechanism for Pr55(gag) translation may help explain the high levels of translation of this protein in the face of major RNA structural barriers to scanning ribosomes found in the gag 5' UTR. The gag IRES activity described here also drives translation of a novel 40-kDa Gag isoform through translational initiation at an internal AUG codon found near the amino terminus of the Pr55(gag) capsid domain. Our findings suggest that this low-abundance Gag isoform may be important for wild-type replication of HIV-1 in cultured cells. The activities of the HIV-1 gag IRES may be an important feature of the HIV-1 life cycle and could serve as a novel target for antiretroviral therapeutic strategies.
Carbon nanotube–vitrimer composite for facile and efficient photo-welding of epoxy (2014)

Assembling epoxy, one of the most common and widely used thermosets, by welding with remote control is extremely difficult and has not been realized so far, as epoxy cannot melt or be dissolved. Here we present a very simple but highly efficient solution by exploring the photothermal effect of carbon nanotubes (CNTs) to manipulate the transesterification reaction in vitrimers. The carbon nanotube dispersed vitrimer epoxy presented here can be welded by light within seconds or minutes. Moreover, various CNT–vitrimer epoxy materials with different chemical compositions and physical properties can be joined together. Furthermore, transmission welding can be used to weld CNT–vitrimers with other kinds of epoxy or thermoplastic polymers, which is not applicable to welding by direct heating and impossible to realize using the currently available photoweldable covalently cross-linked polymer networks. Additionally, these networks can be efficiently healed by light without the involvement of any glue or sealing agents.
Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies (1991)

Immunogenic regions of the gp41 transmembrane protein of human immunodeficiency virus type 1 (HIV-1) were previously mapped by examining polyclonal sera from HIV-infected patients and rodent polyclonal and monoclonal antibodies (MAbs) to peptides of gp41. To define the epitopes within these regions to which infected humans respond during the course of infection, the specificity of human MAbs to these regions had to be studied. Using 10 human MAbs identified initially by their reactivity to whole gp41 in HIV-1 lysates, the epitopes within the immunodominant region of gp41 and within a second immunogenic region of gp41 have been mapped. Thus, five MAbs (from five different patients) to the immunodominant domain of gp41 in the vicinity of the cysteines at positions 598 and 604 (hereinafter designated cluster I) reacted with a stretch of 11 amino acids from positions 590 to 600. Four of these five MAbs were reactive with linear epitopes, while one MAb required the conformation conferred by the disulfide bridge between the aforementioned cysteines. Three MAbs to cluster I revealed dissociation constants ranging from 10(-6) to 10(-8) M, depending on the MAb tested and the size of the synthetic or recombinant peptide used in the assay. Five additional MAbs reacted with a second immunogenic region between positions 644 and 663 (designated cluster II). Four of these five MAbs were specific for conformational determinants. Titration of sera from HIV-infected patients showed that there was about 100-fold more antibody to cluster I than to cluster II in patients' sera, confirming the immunodominance of cluster I.
A naming system for feature-based service specification in distributed operating systems (1991)

The paper describes a naming system that allows a service to evolve or reconfigure in functionality by adding and removing features and still co-exist with its previous versions. The underlying naming model has two aspects: (1) (Attribute_name, Attribute_value) pair based characterization of service features which allows the meta information on a service to be represented as a collection of such pairs (as in X.500 and Universal Naming Protocol). At low level, the name server provides parse and match operations on the (attribute, value) pairs using which high level name binding operations, viz., name registration and name resolution, are constructed. (2) Data-driven communication paradigm which enables different versions of a client and server to communicate with one another. In this paradigm, a server matches the attributes requested by a client with those it supports, and invokes service specific functions named by the attributes. Since attributes refer to orthogonal features, client and server can evolve independently by adding or removing attributes and still communicate. With this model of specifying services, name server functions may be factorized from service specific functions and implemented in a generic fashion in terms of parse and match operations and function invocations. The paper also describes language support for the naming system and implementation issues.
Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target (2015)

Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arginine transporters CAT-1 and CAT-2B, and that the majority of newly diagnosed patients' blasts have deficiencies in the arginine-recycling pathway enzymes argininosuccinate synthase and ornithine transcarbamylase, making them arginine auxotrophic. BCT-100, a pegylated human recombinant arginase, leads to a rapid depletion in extracellular and intracellular arginine concentrations, resulting in arrest of AML blast proliferation and a reduction in AML engraftment in vivo. BCT-100 as a single agent causes significant death of AML blasts from adults and children, and acts synergistically in combination with cytarabine. Using RNA sequencing, 20 further candidate genes which correlated with resistance have been identified. Thus, AML blasts are dependent on arginine for survival and proliferation, as well as depletion of arginine with BCT-100 of clinical value in the treatment of AML.
Immunogenicity of interferon-alpha 2 in therapy: structural and physiological aspects. (1999)

Recombinant human interferon (rIFN)-alpha 2 has been approved for therapeutic application in a range of human oncological and viral diseases. However, some patients can develop strictly specific antibody response to rIFN-alpha 2, which may diminish its therapeutic potential. Such humoral response appears to be quite complex and obviously depends on multiple parameters. Our review is aimed primarily to factors associated with structural modifications of rIFN-alpha 2 that we consider crucial for formation of therapy-induced antibodies. These factors are either related to inherent conformational differences between three IFN-alpha 2 subvariants or to immunogenically active contaminating derivatives resulting from production, purification and storage of this recombinant protein. In addition, the role of treatment regimen and physiological variables modulating the immune response to rIFN-alpha 2 in the challenged organism are mentioned.
Extracellular Matrix Bioscaffolds for Orthopaedic Applications (2006)

Biologic scaffold materials composed of extracellular matrix elicit distinct host-tissue histologic and morphologic responses, depending on species of origin, tissue of origin, processing methods, and/or method of terminal sterilization.
Induction of Pemphigus Phenotype by a Mouse Monoclonal Antibody Against the Amino-Terminal Adhesive Interface of Desmoglein 3 (2003)

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease that is caused by IgG autoantibodies against the cadherin-type adhesion molecule desmoglein (Dsg)3. Previously, we have generated an active mouse model for PV by adoptive transfer of Dsg3(-/-) splenocytes. In this study, we isolated eight AK series, anti-Dsg3 IgG mAbs from the PV mouse model, and examined their pathogenic activities in induction of blister formation. Intraperitoneal inoculation of the AK23 hybridoma, but not the other AK hybridomas, induced the virtually identical phenotype to that of PV model mice or Dsg3(-/-) mice with typical histology of PV. Epitope mapping with domain-swapped and point-mutated Dsg1/Dsg3 molecules revealed that AK23 recognized a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg, as predicted by the crystal structure. The epitopes of the mAbs that failed to show apparent pathogenic activity were mapped in the middle to carboxyl-terminal extracellular region of Dsg3, where no direct intermolecular interaction was predicted. These findings demonstrate the pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes, and suggest the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus.
Interference-filter-tuned, alignment-stabilized, semiconductor external-cavity laser (1988)

We compared the angular alignment tolerance and the tuning range of a novel interference-filter-tuned semiconductor external-cavity laser based on a degenerate resonator with characteristics similar to those of a conventional grating-tuned external-cavity laser using a 1300-nm In GaAsP Fabry-Perot laser with an antireflection-coated facet as the gain medium. The interference-filter cavity had a 260-fold greater alignment tolerance (+/-26 versus +/-0.1 mrad) and nearly the same tuning range (90 versus 110 nm) as the grating-tuned cavity.
Conversion Functions for Symmetric Key Ciphers (2006)

As a general design criterion, a symmetric key cipher should not be closed under functional composition due to the implications on the security of the cipher. However, there are scenarios in which this property is desirable and can be obtained without reducing the security of a cipher by increasing the computational workload of the cipher. We expand the idea of a symmetric key cipher being closed under functional composition to a more general scenario where there exists a function that converts the ciphertext resulting from encryption under a specific key to the ciphertext corresponding to encryption with another key. We show how to perform such a conversion without exposing the plaintext. We discuss the tradeoff between the computational workload and security, and the relationship between such conversions and proxy cryptography. We conclude with a discussion of some practical applications of our results.
Anti-Inflammatory Effect of Heat Shock Protein Induction Is Related to Stabilization of IκBα Through Preventing IκB Kinase Activation in Respiratory Epithelial Cells (2000)

Heat shock protein (HSP) induction confers protection against diverse forms of cellular and tissue injury. However, the mechanism by which HSP exerts cytoprotective effects is unclear. Because HSP induction inhibits genetic expression of pro-inflammatory cytokines, the transcription of which is dependent on NF-kappa B activation, we explored the relationship between the anti-inflammatory effect of HSP induction and the NF-kappa B/I kappa B alpha pathway. Both HS and sodium arsenite treatment increased HSP70 expression time dependently at mRNA and protein levels. Prior induction of HSP suppressed cytokine-induced IL-8 and TNF-alpha expression at both mRNA and protein levels. Although HSP induction did not affect total cellular expression of NF-kappa B, TNF-alpha-induced increase in NF-kappa B-DNA binding activity and nuclear translocation of the p65 subunit of NF-kappa B were inhibited by prior HSP induction, suggesting that activation of NF-kappa B was blocked. Cytokine-induced I kappa B alpha phosphorylation and its degradation were blocked in HSP-induced cells. Immune complex kinase assays demonstrated that TNF-alpha induced increase in I kappa B kinase activity was suppressed by prior HSP induction. These results suggest that the anti-inflammatory effect of HSP induction in respiratory epithelial cells is related to stabilization of I kappa B alpha, possibly through the prevention of I kappa B kinase activation, which thereby inhibits activation of NF-kappa B.
Murine Salmonellosis Studied by Confocal Microscopy: Salmonella typhimurium Resides Intracellularly Inside Macrophages and Exerts a Cytotoxic Effect on Phagocytes In Vivo (1997)

Salmonella typhimurium is considered a facultative intracellular pathogen, but its intracellular location in vivo has not been demonstrated conclusively. Here we describe the development of a new method to study the course of the histopathological processes associated with murine salmonellosis using confocal laser scanning microscopy of immunostained sections of mouse liver. Confocal microscopy of 30-micron-thick sections was used to detect bacteria after injection of approximately 100 CFU of S. typhimurium SL1344 intravenously into BALB/c mice, allowing salmonellosis to be studied in the murine model using more realistic small infectious doses. The appearance of bacteria in the mouse liver coincided in time and location with the infiltration of neutrophils in inflammatory foci. At later stages of disease the bacteria colocalized with macrophages and resided intracellularly inside these macrophages. Bacteria were cytotoxic for phagocytic cells, and apoptotic nuclei were detected immunofluorescently, whether phagocytes harbored intracellular bacteria or not. These data argue that Salmonella resides intracellularly inside macrophages in the liver and triggers cell death of phagocytes, processes which are involved in disease. This method is also applicable to other virulence models to examine infections at a cellular and subcellular level in vivo.
Mechanism of High-Temperature CO2 Sorption on Lithium Zirconate (2003)

Lithium zirconate (Li2ZrO3) is one of the most promising materials for CO2 separation from flue gas at high temperature. This material is known to be able to absorb a large amount of CO2 at around 400-700 degrees C. However, the mechanism of the CO2 sorption/desorption process on Li2ZrO3 is not known yet. In this study, we examined the CO2 sorption/desorption mechanism on Li2ZrO3 by analyzing the phase and microstructure change of Li2ZrO3 during the CO2 sorption/desorption process with the help of thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) analyses. Li2ZrO3 powders were prepared from lithium carbonate (Li2CO3) and zirconium oxide (ZrO2) by the solid-state method, and the CO2 sorption/desorption property was examined by TGA. It was shown that pure Li2ZrO3 absorbs a large amount of CO2 at high temperature with a slow sorption rate. Addition of potassium carbonate (K2CO3) and Li2CO3 in the Li2ZrO3 remarkably improves the CO2 sorption rate of the Li2ZrO3 materials. DSC analysis for the CO2 sorption process indicates that doped lithium/potassium carbonate is in the liquid state during the CO2 sorption process and plays an important role in improving the CO2 uptake rate. XRD analysis for phase and structure change during the sorption/desorption process shows that the reaction between Li2ZrO3 and CO2 is reversible. Considering all data obtained in this study, we proposed a double-shell model to describe the mechanism of the CO2 sorption/desorption on both pure and modified Li2ZrO3.