BN 52021: A Platelet Activating Factor Antagonist for Preventing Post-Transplant Renal Failure: A Double-Blind, Randomized Study (1994)

Brief Communications1 September 1994BN 52021: A Platelet Activating Factor Antagonist for Preventing Post-Transplant Renal Failure: A Double-Blind, Randomized StudyJosep M. GrinoJosep M. GrinoFrom the Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.For The BN 52021 Study Group in Renal Transplantation**Members of the BN 52021 Study Group in Renal Transplantation are listed in the Appendix.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-5-199409010-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Platelet activating factor (a glycerophospholipid) is an inflammatory mediator that plays an important role in allergic and inflammatory processes [1], including ischemic renal failure [2-4]. Ginkgolide BN 52021 is a receptor antagonist for platelet activating factor that exerts a protective effect on renal function in experimental ischemic acute renal failure [5]. Many of the pathophysiologic responses and the microcirculatory failure that result from release of platelet activating factor mimic the responses observed after ischemia and reperfusion injury [6]. For example, selectins, integrins, and platelet activating factor contribute to the adhesion of polymorphonuclear cells to the endothelium [7]. We did a ...References1. Braquet P, Rola-Pleszczynski M. Platelet-activating factor and cellular immune responses. Immunol Today. 1987; 11:345-52. Google Scholar2. Pirotzky E, Bidault J, Burtin C, Gubler MC, Benveniste J. Release of platelet activating factor, slow reacting substance and vasoactive amines from isolated rat kidneys. Kidney Int. 1984; 25:404-10. Google Scholar3. Lopez-Farre A, Torralbo M, Lopez-Novoa JM. Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. Biochem Biophys Res Commun. 1988; 152:129-35. Google Scholar4. Schlondorff D, Neuwirth R. Platelet-activating factor and the kidney. Am J Physiol. 1986; 251:F1-F11. Google Scholar5. Torras J, Bordalba JR, Seron D, Moliner R, Carrera M, Valles J, et al. Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model. Transpl Int. 1993; 6:236-8. Google Scholar6. Ontell SJ, Makowka L, Boccagni P, Starzl TE. The role of PAF and its antagonism in transplantation: Organ ischemia and preservation. In: Handley DA, Saunders RN, Houlihan WJ, Tomesch JC, eds. Platelet-Activating Factor in Endotoxin and Immune Diseases. New York: Marcel Dekker, Inc; 1990:419-47. Google Scholar7. Zimmerman GA, Prescott SM, McIntyre TM. Endothelial cells interactions with granulocytes: tethering and signaling molecules. Immunol Today. 1992; 13:93-100. Google Scholar8. Grino JM, Castelao AM, Seron D, Gonzalez C, Galceran JM, Gil-Vernet S, et al. Antilymphocyte globulin versus OKT3 induction therapy in kidney cadaveric kidney transplantation: a prospective randomized study. Am J Kidney Dis. 1992; 20:603-10. Google Scholar9. Campbell MJ, Gardner MJ. Calculating confidence intervals for some non-parametric analyses. Br Med J. 1988; 296:1454-6. Google Scholar10. Conte JV Jr, Katz NM, Wallace RB, Foegh ML. Long-term lung preservation with the PAF antagonist BN 52021. Transplantation. 1991; 51:1152-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Josep M. GrinoAffiliations: From the Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.For The BN 52021 Study Group in Renal Transplantation**Members of the BN 52021 Study Group in Renal Transplantation are listed in the Appendix.Corresponding Author: Josep M. Grino, MD, Department of Nephrology, Hospital de Bellvitge, C. Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. 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