gebhart/patrepeval huggingface dataset:
Erstes Beispiel eines ethylenselektiven löslichen Ziegler‐Katalysators der Zirconocen‐Klasse (1989)

Eindeutige Struktur‐Aktivitäts‐Beziehungen ergab die Polymerisation von Ethylen und Propylen mit den neuen, einfach herstellbaren Katalysatoren 1 und 2 . In Gegenwart von Methylaluminoxan polymerisiert 1 mit hoher Aktivität Propylen zu Polypropylen hoher mittlerer Molmasse und enger Molmassenverteilung; 2 ist bei dieser Reaktion inaktiv, polymerisiert dafür aber Ethylen. Entscheidend scheint der Öffnungswinkel des Indenyl‐Ligandensystems zu sein. magnified image
Driver‐circuits‐integrated LCDs based on novel amorphous In‐Ga‐Zn‐oxide TFT (2010)

Abstract— A liquid‐crystal panel integrated with a gate driver and a source driver by using amorphous In—Ga—Zn‐oxide TFTs was designed, prototyped, and evaluated. By using the process of bottom‐gate bottom‐contact (BGBC) TFTs, amorphous In—Ga—Zn‐oxide TFTs with superior characteristics were provided. Further, for the first time in the world, a 4‐in. QVGA liquid‐crystal panel integrated with a gate driver and a source driver was developed by using BGBC TFTs formed from an oxide semiconductor. By evaluating the liquid‐crystal panel, its functionality was successfully demonstrate. Based on the findings, it is believed that the novel BGBC amorphous In—Ga—Zn‐oxide TFT will be a promising candidate for future large‐screen backplanes having high definition.
Detection and feature extraction of atrial tachyarrhythmias (2006)

Analysis of atrial tachyarrhythmias requires that an atrial signal has first been extracted from the electrocardiogram (ECG), resulting in the so-called residual ECG. This article introduces a novel method for atrial rhythm analysis that condenses different signal parameters into three rhythm features, reflecting signal structure, frequency regularity, and waveform type. A three-stage method for atrial signal analysis is introduced and comprises atrial signal extraction, atrial signal characterization, and atrial rhythm feature analysis. The present study is example based and illustrates the potential of the method. A quantitative evaluation of the performance of the method will be done in a future study
Residential Control Considerations (1982)

This paper discusses the need for standards for residential-control communication systems, identifies some efforts to create a standard, and states requirements we feel the standard should meet. This paper also describes the environments-regulatory and electromagnetic-in which the systems must operate.
고령의 고관절 골절에서의 사망율 (1997)

The significant risk to life associated with the hip fracture has long been recognized, and the reports of poor prognosis are well known with wide range of mortality rates. We retrospectively studied 164 patients(older than 60 years) who had a hip fracture to determine the effects of the age, treatment methods, pre-existing medical condition, operative delay after injury, type of fracture, and others on patient mortality. The summarized results were as follows; l. One hundred twenty three patients survived and forty one patients died (overall mortality rate; 25.0 %). 2. Twenty one patients died within one year (one-year mortality rate; 12.8 %). 3. Mortality was related to age of patient at injury, ASA classification, absense or presence of operative treatment. operation-related complication, which were statistically significant (P < 0.05). 4. The operative delay after injury did not influence mortality, but we think that it is not statistically because this study was done retrospectively.
Cerebrospinal fluid markers reveal intrathecal inflammation in progressive multiple sclerosis (2015)

The cell-specific biomarkers of intrathecal inflammation may improve diagnosis and management of neuroimmunological diseases and provide pharmacodynamic markers for future therapeutic developments in patients with intrathecal inflammation that is not captured by imaging, such as in progressive MS.
Pirarubicin, A Novel Derivative of Doxorubicin THP-COP Therapy for Non-Hodgkinʼs Lymphoma in the Elderly (1990)

Pirarubicin (tetrahydropyranyl adriamycin, THP) is a derivative of doxorubicin. Forty-three non-Hodgkin's lymphoma (NHL) patients 65 years of age or older were treated with a combination therapy including cyclophosphamide (CPA), vincristine (VCR), prednisone (PSL), and THP (THP-COP). The THP-COP regimen consisted of THP, 30 mg/m2 i.v. on day 1; CPA, 500 mg/m2 i.v. on day 1; VCR, 1.0 mg/m2 i.v. on day 1; and PSL, 60 mg orally for 5 consecutive days. The sequence was repeated at 21- to 28-day intervals for a minimum of four cycles. Of the 43 patients, 13 (30.2%) achieved a complete response (CR) and 21 (48.8%) a partial response (PR). Nine patients (21.0%) had primary treatment failure, which included a minimal response, no change, and progressive disease. Thus, the response rate (CR or PR) was 79.1%. Twenty-six of 29 previously untreated patients (89.7%) achieved a CR or PR, whereas only 8 of 14 previously treated patients (57.1%) did (p less than 0.05). Because THP is a derivative of doxorubicin, the results for the eight patients previously treated with doxorubicin are noteworthy; four achieved a CR or PR. No patients had any cardiac toxicity, including congestive heart failure, attributable to THP. Furthermore, four patients who showed a decreased ejection fraction before treatment completed the full course of THP-COP chemotherapy without any progression of the cardiac complication. THP is considered to be active against NHL in the elderly and comparable to doxorubicin in combination chemotherapy.
Reversible Storage of Lithium in Silver‐Coated Three‐Dimensional Macroporous Silicon (2010)

Three-dimensional macroporous silicon (see image) was synthesized by a magnesiothermic reduction method as an anode material for lithium ion batteries. An improved lithium storage performance was obtained after coating silver nanoparticles on the surface of the silicon. The silver-coated 3D macroporous silicon shows promise as an anode material in lithium ion batteries. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Aptamer-Based Electrochemical Detection of Picomolar Platelet-Derived Growth Factor Directly in Blood Serum (2006)

We report an electrochemical, aptamer-based (E-AB) sensor for the detection of platelet-derived growth factor (PDGF) directly in blood serum. The E-AB approach employs alternating current voltammetry to monitor target-induced folding in a methylene blue-modified, PDGF-binding aptamer. The sensor is sensitive, highly selective, and essentially reagentless: we readily detect the BB variant of PDGF at 1 nM directly in undiluted, unmodified blood serum and at 50 pM (1.25 ng/mL) in serum-diluted 2-fold with aqueous buffer. The sensitivity and selectivity achieved by this sensor match or significantly exceed those of the best analogous optical approaches. For example, the detection limit attained in 50% serum is achieved against a >25 million-fold excess of contaminating blood proteins and represents a 4 order of magnitude improvement over the most sensitive optical PDGF aptasensor reported to date. Moreover, the E-AB sensor combines these promising attributes in a platform that is reusable, label-free, and electronic. Given these advantages, E-AB sensors appear well suited for implementation in portable microdevices directed at the direct detection of proteins and small molecules in complex, largely unprocessed clinical samples.
Application of a Novel Radioimmunoassay to Identify Baculovirus Structural Proteins That Share Interspecies Antigenic Determinants (1981)

Immunological comparisons were made of baculovirus structural proteins by using a modification of the radioimmunological techniques described by Renart et al. (Proc. Natl. Acad. Sci. U.S.A. 76: 3116-3120, 1979) and Towbin et al. (Proc. Natl. Acad. Sci. U.S.A. 76: 4350-4354, 1979). Viral proteins were electrophoresed in polyacrylamide gels, transferred to nitrocellulose, and incubated with viral antisera, and the antibodies were detected with (125)I-labeled Staphylococcus aureus protein A. Antisera were prepared to purified and intact virions from five baculoviruses: Autographa californica, Porthetria dispar, Trichoplusia ni, and Heliothis zea nuclear polyhedrosis viruses (NPVs) and T. ni granulosis virus (GV). These antisera were tested against the virion structural polypeptides of 17 different species of baculoviruses. Specific multiple-nucleocapsid NPV (MNPV), single-nucleocapsid NPV (SNPV), and GV virion polypeptides were shown to have similar antigenic determinants and thus be immunologically related. The molecular weights of the virion polypeptides with cross-reacting antigenic determinants were identified. Antisera prepared to purified A. californica and H. zea MNPV polyhedrin (the occlusion body protein from NPVs) recognized antigenic determinants on all the polyhedrins and granulins (occlusion body protein from GVs) that were tested. No immunological relationship was detected between A. californica MNPV polyhedrin and any of the A. californica MNPV virion structural polypeptides present on either the virus isolated from occlusion bodies or A. californica MNPV extracellular virus from infected-cell cultures.
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. (1990)

The genetic and molecular analysis of the Notch locus, which codes for a transmembrane protein sharing homology with the mammalian epidermal growth factor, suggests that the Notch protein is involved in a cell interaction mechanism essential for the differentiation of the embryonic nervous system of Drosophila. Taking advantage of the negative complementation between two Notch mutations that affect the extracellular domain of the protein, we have tried to dissect the genetic circuitry in which Notch is integrated by searching for genes whose products may interact with the Notch protein. This genetic screen has led to the identification of a surprisingly restricted set of interacting loci, including Delta and mastermind. Like Notch, both of these genes belong to a group of loci, the neurogenic loci, which have been previously identified by virtue of their similar mutant phenotype affecting early neurogenesis. We extend these studies by systematically exploring interactions between specific mutations in the Notch molecule and the other neurogenic genes. Furthermore, we show that the molecular lesions of two Notch alleles (nd and nd2), which interact dramatically with mastermind mutations, as well as with a mutation affecting the transducin homologous product of the neurogenic locus Enhancer of split, involve changes in the intracellular domain of the protein.
Therapy of human B‐cell lymphoma bearing scid mice is more effective with anti‐CD19‐and anti‐CD38‐saporin immunotoxins used in combination than with either immunotoxin used alone (1995)

The CD19+ CD38+ human Burkitt's lymphoma cell line Ramos grows aggressively when injected intravenously (i.v.) into severe combined immunodeficient (SCID) mice, killing 100% of animals within a 33-42 day period with widely disseminated disease. Treatment commencing 7 days after i.v. injection of Ramos cells, with 3 doses of an anti-CD19 immunotoxin (IT; BU12-SAPORIN) or an anti-CD38IT (OKT10-SAPORIN) led to a significant prolongation of survival compared with sham-treated controls; the anti-CD38 IT gave the greatest prolongation of survival, but all treated animals eventually succumbed to disease. When both ITs were used in combination at equivalent dose levels, the therapeutic outcome was significantly improved over that obtained for single IT therapy, with 20% of animals surviving disease-free to 300 days. When anti-CD38 IT was given in combination with anti-CD19 antibody there was no therapeutic improvement over anti-CD38 IT used alone. However, when anti-CD19 IT was given in combination with CD38 antibody, a significant prolongation of survival ensued over that obtained with anti-CD19 IT alone, though this was not as significantly pronounced as that obtained when both ITs were used in combination and was only as good as the survival obtained with OKT10 antibody used alone. CD19 and CD38 are expressed on the surface of the vast majority of B-cell lymphoma and common acute lymphoblastic leukaemia cells, and our findings provide a sound rationale for a combination immunotoxin trial in these diseases directed against both these target molecules.
PolyIC GE11 polyplex inhibits EGFR‐overexpressing tumors (2012)

Phage display has identified the dodecapeptide YHWYGYTPQNVI (GE11) as a ligand that binds to the epidermal growth factor receptor (EGFR) but does not activate the receptor. Here, we compare the EGFR binding affinities of GE11, EGF, and their polyethyleneimine-polyethyleneglycol (PEI-PEG) conjugates. We found that although GE11 by itself does not exhibit measurable affinity to the EGFR, tethering it to PEI-PEG increases its affinity markedly, and complex formation with polyinosine/cytosine (polyIC) further enhances the affinity to the submicromolar range. PolyIC/PPGE11 has a similar strong antitumor effect against EGFR overexpressing tumors in vitro and in vivo, as polyIC/polyethyleneimine-polyetheleneglycol-EGF (polyIC/PP-EGF). Absence of EGFR activation, as previously shown by us and easier production of GE11 and GE11 conjugates, confer polyIC/PPGE11 a significant advantage over similar EGF-based polyplexes as a potential therapy of EGFR overexpressing tumors.
Ferroelectric liquid crystals (1975)

A general symmetry argument is presented, and experiments on newly synthesized p-decyloxybenzylidene p'-amino 2-methyl butyl cinnamate are described, demonstrating that chiral smectic C and H liquid crystals are ferroelectric. Some of the properties of this new class of ferro-electrics are discussed.
The Many Roles of Chemokines and Chemokine Receptors in Inflammation (2006)

In this review, the authors discuss the properties of chemokines and their receptors and highlight the roles of these chemoattractants in selected clinical disorders.
A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study (2015)

This study confirms, in a multicenter setting, the preliminary results seen in previous phase II trials of rindopepimut. A pivotal, double-blind, randomized, phase III trial ("ACT IV") is under way.
Imaging and manipulation properties of nanoparticles in scanning tunneling microscopy (1996)

Nanometer-sized particles manufactured by two different techniques and deposited on wet chemically treated Si(111) substrates are explored at room temperature with a scanning tunneling microscope (STM) in the light of their stability upon repeated imaging and the feasibility to manipulate them with the probing tip. The two preparation techniques include field-induced transfer of Au from the STM tip stimulated by voltage pulsing and a wet chemical method. In the latter case, a colloidal solution of specified admixtures is prepared delivering CdS particles with a diameter of approximately 5 nm. In STM images, they protrude as 50-nm-high isolated hillocks or as one particle-high islands containing a varying number of individual constituents. The STM imaging process does not cause any changes in the structure of the islands or in the position of single particles. Upon traversing the tip through particle islands, several constituents can be removed. Depending on the deposition conditions in the field-induced transfer mode, the created Au deposits either adhere strongly to the substrate or they are displaced by the STM tip while imaging.
Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer (2015)

NCT02134015.
Effects of Artery Intervention Embolic Agents in Children With Head and Neck Hemangioma (2008)

Objective
To investigate the artery intervention embolic agent effects on pediatric patients with head and neck hemangioma, and their implications in interventional treatment.


Methods
56 pediatric patients with head and neck hemangioma who accepted interventional treatment were admitted to the Sichuan Cancer Hospital from June 2003 to August 2006, including 35 boys and 21 girls (aged from 2 months to 16 years old). There were 41 pediatric patients with head and face hemangioma, and 15 pediatric patients with neck and shoulder hemangioma. Selective and superselective artery intubation were adopted. Different types of embolic materials were used according to artery types identified with the artery angiography. Embolism material combinations were ① steel wire collar; ② steel wire collar + gelatin sponge particles + hardener; ③ gelatin sponge particles + gelatin sponge strips + hardener; and ④ gelatin sponge strips + hardener. Such materials were used for embolism treatment of arteriovenous fistula (AVF), vascular net malformation, and access artery. A follow-up of 1~5 years was conducted after the interventional embolism therapy.


Results
47 pediatric patients (84%, 47/56) were cured by embolism therapy in a follow-up of 1~5 years, with stable therapeutic effects. Interventional embolism therapy was effective in the other 9 pediatric patients (16%, 9/56) in a follow-up of 2 years or more.


Conclusion
According to the interventional artery angiography in children patients with head and neck hemangioma, the interventional embolism therapy with the following combinations provided the satisfactory effects: ① steel wire collar + gelatin sponge particles + hardener; ② gelatin sponge particles + gelatin sponge strips + hardener; ③ gelatin sponge strips + hardener.


Key words: 
child; head and neck hemangioma; embolic agents; angiography; digital subtraction
Design parameters for fluoride multimode fibers (1991)

Numerical calculations of losses due to polymer coatings and macrobending have been made for step-index multimode fluoride fibers. To minimize such losses, fiber parameters must be chosen to give a large value for V, the normalized frequency. Due to the long propagation wavelength (2.5 mu m) for fluoride fiber, the parameters needed are very different from those of silica fiber. Using the criterion that >or=90% of the modes have losses <or=0.01 dB/km, it was found that the cladding diameters need to be rather large compared to step-index silica fiber parameters. Although the mode distributions are unknown for fluoride fiber, using a theoretical Gaussian distribution, losses were calculated for the various fiber parameters.<<ETX>>
Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes (2012)

Fibroblastic reticular cells (FRC) form the structural backbone of the T cell rich zones in secondary lymphoid organs (SLO), but also actively influence the adaptive immune response. They provide a guidance path for immigrating T lymphocytes and dendritic cells (DC) and are the main local source of the cytokines CCL19, CCL21, and IL-7, all of which are thought to positively regulate T cell homeostasis and T cell interactions with DC. Recently, FRC in lymph nodes (LN) were also described to negatively regulate T cell responses in two distinct ways. During homeostasis they express and present a range of peripheral tissue antigens, thereby participating in peripheral tolerance induction of self-reactive CD8(+) T cells. During acute inflammation T cells responding to foreign antigens presented on DC very quickly release pro-inflammatory cytokines such as interferon γ. These cytokines are sensed by FRC which transiently produce nitric oxide (NO) gas dampening the proliferation of neighboring T cells in a non-cognate fashion. In summary, we propose a model in which FRC engage in a bidirectional crosstalk with both DC and T cells to increase the efficiency of the T cell response. However, during an acute response, FRC limit excessive expansion and inflammatory activity of antigen-specific T cells. This negative feedback loop may help to maintain tissue integrity and function during rapid organ growth.
A novel taxonomic marker that discriminates between morphologically complex actinomycetes (2013)

In the era when large whole genome bacterial datasets are generated routinely, rapid and accurate molecular systematics is becoming increasingly important. However, 16S ribosomal RNA sequencing does not always offer sufficient resolution to discriminate between closely related genera. The SsgA-like proteins are developmental regulatory proteins in sporulating actinomycetes, whereby SsgB actively recruits FtsZ during sporulation-specific cell division. Here, we present a novel method to classify actinomycetes, based on the extraordinary way the SsgA and SsgB proteins are conserved. The almost complete conservation of the SsgB amino acid (aa) sequence between members of the same genus and its high divergence between even closely related genera provides high-quality data for the classification of morphologically complex actinomycetes. Our analysis validates Kitasatospora as a sister genus to Streptomyces in the family Streptomycetaceae and suggests that Micromonospora, Salinispora and Verrucosispora may represent different clades of the same genus. It is also apparent that the aa sequence of SsgA is an accurate determinant for the ability of streptomycetes to produce submerged spores, dividing the phylogenetic tree of streptomycetes into liquid-culture sporulation and no liquid-culture sporulation branches. A new phylogenetic tree of industrially relevant actinomycetes is presented and compared with that based on 16S rRNA sequences.
Vinylic Polymerization and Copolymerization of Norbornene and Ethene by Homogeneous Chromium(III) Catalysts (2001)

Homogeneous chromium(III) catalysts of the type [Cp′CrMeCl]2/MAO (Cp′ = cyclopentadienyl, pentamethylcyclopentadienyl, indenyl, fluorenyl) have been synthesized to investigate the influence of the electronic nature and the sterical demand of different Cp′-ligands on the polymerization and copolymerization of norbornene and ethene. In the case of norbornene polymerization the catalyst activity is increased by intensifying the electron donating character of the Cp′-ligand whereas the sterical demand affects the crystallinity of polynorbornene. The use of the [Cp*CrMeCl]2 /MAO and the [FluCrMeCl]2 /MAO catalyst for norbornene-ethene copolymerization under various polymerization conditions led to the formation of norbornene-ethene copolymers with different microstructures ranging from statistical norbornene-ethene copolymers over vinyl-terminated norbornene macromonomers to norbornene-ethene block copolymers. Furthermore highly linear, ultra high molecular polyethylene can be obtained using the [FluCrMeCl]2/MAO catalyst.