gebhart/patrepeval huggingface dataset:
Semi-Supervised Ridge Regression with Adaptive Graph-Based Label Propagation (2018)

In order to overcome the drawbacks of the ridge regression and label propagation algorithms, we propose a new semi-supervised classification method named semi-supervised ridge regression with adaptive graph-based label propagation (SSRR-AGLP). Firstly, we present a new adaptive graph-learning scheme and integrate it into the procedure of label propagation, in which the locality and sparsity of samples are considered simultaneously. Then, we introduce the ridge regression algorithm into label propagation to solve the “out of sample” problem. As a consequence, the proposed SSSRR-AGLP integrates adaptive graph learning, label propagation and ridge regression into a unified framework. Finally, an effective iterative updating algorithm is designed for solving the algorithm, and the convergence analysis is also provided. Extensive experiments are conducted on five databases. Through comparing the results with some well-known algorithms, the effectiveness and superiority of the proposed algorithm are demonstrated.
Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus. (1993)

Molecular dissection of mechanisms that govern the differentiated cardiac phenotype has, for cogent technical reasons, largely been undertaken to date in neonatal ventricular myocytes. To circumvent expected limitations of other methods, the present study was initiated to determine whether replication-deficient adenovirus would enable efficient gene transfer to adult cardiac cells in culture. Adult rat ventricular myocytes were infected, 24 h after plating, with adenovirus type 5 containing a cytomegalovirus immediate-early promoter-driven lacZ reporter gene and were assayed for the presence of beta-galactosidase 48 h after infection. The frequency of lacZ+ rod-shaped myocytes was half-maximal at 4 x 10(5) plaque-forming units (PFU) and approached 90% at 1 x 10(8) PFU. Uninfected cells and cells infected with lacZ- virus remained colorless. Beta-galactosidase activity concurred with the proportion of lacZ+ cells and was contingent on the exogenous lacZ gene. At 10(8) PFU/dish, cell number, morphology, and viability each were comparable to uninfected cells. Thus, adult ventricular myocytes are amenable to efficient gene transfer with recombinant adenovirus. The relative uniformity for gene transfer by adenovirus should facilitate tests to determine the impact of putative regulators upon the endogenous genes and gene products of virally modified adult ventricular muscle cells.
Application of capacitance techniques in sensor design (1986)

By reconsidering the basic principles of capacitance, and also clarifying some of the misconceptions about the principles of guarding, which were correctly described by Kelvin more than a century ago, it is shown how guarded multi terminal capacitor geometries can be designed, analytically precalculated and correctly measured using simplified transformer bridge systems with phase-sensitive detection. An overview is given of the archetypal multi terminal capacitor configurations as well as ways to modify them for practical sensor designs. Detrimental side-effects are discussed and rules for practical designs are given. The possibilities for combining bridge circuits with simultaneous and sequential measurements of complex sensors are described. Expectations for future developments, partly based on silicon microfabrication techniques, are discussed and a comparison of the major aspects of capacitive sensors with resistive strain gauges and inductive sensors is given.
The reactivity of calcium oxide towards carbon dioxide and its use for energy storage (1974)

Abstract By using calcium carbonate powder of particle size ∼ 10 nm (and therefore of high surface area) it has been shown that the reaction CaCO 3 ⇄ CaO + CO 2 can be made almost wholly reversible. A reactivity of 93% was achieved, (i.e. 93% of the calcium oxide reacted with carbon dioxide) and this was maintained for 30 24‐h decomposition‐back reaction cycles at 629 °C with no detectable decrease. This material has an energy storage capacity of 200 Wh/lb, but only about 1 kWh/ft. 3 When this calcium carbonate was pressed, however, to increase its bulk density (from 0.1 to ∼ 1 g/ml) there was a large decrease in its surface area and a smaller decrease in its reactivity on undergoing a few decomposition and back reaction cycles. Scaling up of the sample size from 20 mg to 10 g only had a small (× 3) effect on the rates of decomposition and back reaction.
Thiazolothiazoles. II. Parent heterocycle and its carboxylic and amino derivatives (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiazolothiazoles. II. Parent heterocycle and its carboxylic and amino derivativesJohn Raven Johnson, Don H. Rotenberg, and Roger KetchamCite this: J. Am. Chem. Soc. 1970, 92, 13, 4046–4050Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://doi.org/10.1021/ja00716a036RIGHTS & PERMISSIONSArticle Views1282Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (762 KB) Get e-Alerts Get e-Alerts
Characterization of a noncovalent lipocalin complex by liquid chromatography/electrospray ionization mass spectrometry. (2004)

Nanoscale liquid chromatography coupled to electrospray ionization mass spectrometry was used to identify the nature of the ligand that binds noncovalently to siderocalin (lipocalin 2). The folded state siderocalin-ligand complex was separated from free, unfolded siderocalin using reversed phase chromatography, and the molecular weight of the siderocalin ligand was then determined from the deconvoluted molecular weights of the complex and of the free protein. The ligand was identified as dihydroxybenzoyl-serine, a breakdown product of enterobactin, an iron-chelating compound ("siderophore") synthesized in bacteria. These results demonstrate that, in some cases, electrostatic noncovalent protein complexes can survive the denaturing conditions of reversed phase liquid chromatography and the gas phase transfer occurring during electrospray ionization.
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. (1999)

TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown thalidomide to be a relatively selective inhibitor of TNF-alpha production in vivo and in vitro. Additionally, we have recently reported that thalidomide exerts a costimulatory effect on T cell responses. To develop thalidomide analogues with increased anti-TNF-alpha activity and reduced or absent toxicities, novel TNF-alpha inhibitors were designed and synthesized. When a selected group of these compounds was examined for their immunomodulatory activities, different patterns of cytokine modulation were revealed. The tested compounds segregated into two distinct classes: one class of compounds, shown to be potent phosphodiesterase 4 inhibitors, inhibited TNF-alpha production, increased IL-10 production by LPS-induced PBMC, and had little effect on T cell activation; the other class of compounds, similar to thalidomide, were not phosphodiesterase 4 inhibitors and markedly stimulated T cell proliferation and IL-2 and IFN-gamma production. These compounds inhibited TNF-alpha, IL-1beta, and IL-6 and greatly increased IL-10 production by LPS-induced PBMC. Similar to thalidomide, the effect of these agents on IL-12 production was dichotomous; IL-12 was inhibited when PBMC were stimulated with LPS but increased when cells were stimulated by cross-linking the TCR. The latter effect was associated with increased T cell CD40 ligand expression. The distinct immunomodulatory activities of these classes of thalidomide analogues may potentially allow them to be used in the clinic for the treatment of different immunopathological disorders.
Anti-Tumor Activity of Human T Cells Expressing the CC49-zeta Chimeric Immune Receptor (1999)

A chimeric immune receptor consisting of an extracellular antigen-binding domain derived from the CC49 humanized single-chain antibody, linked to the CD3zeta signaling domain of the T cell receptor, was generated (CC49-zeta). This receptor binds to TAG-72, a mucin antigen expressed by most human adenocarcinomas. CC49-zeta was expressed in CD4+ and CD8+ T cells and induced cytokine production on stimulation. Human T cells expressing CC49-zeta recognized and killed tumor cell lines and primary tumor cells expressing TAG-72. CC49-zeta T cells did not mediate bystander killing of TAG-72-negative cells. In addition, CC49-zeta T cells not only killed FasL-positive tumor cells in vitro and in vivo, but also survived in their presence, and were immunoprotective in intraperitoneal and subcutaneous murine tumor xenograft models with TAG-72-positive human tumor cells. Finally, receptor-positive T cells were still effective in killing TAG-72-positive targets in the presence of physiological levels of soluble TAG-72, and did not induce killing of TAG-72-negative cells under the same conditions. This approach is being currently being utilized in a phase I clinical trial for the treatment of colon cancer.
Administratively Scoped IP Multicast (1998)

This document defines the "administratively scoped IPv4 multicast space" to be the range 239.0.0.0 to 239.255.255.255.In addition, it describes a simple set of semantics for the implementation of Administratively Scoped IP Multicast.Finally, it provides a mapping between the IPv6 multicast address classes [RFC1884] and IPv4 multicast address classes.
Solution and solid phase chemical synthesis of arabinonucleotides (1989)

A fast and convenient procedure for the chemical synthesis of arabinonucleotides, which eliminates the multistep protection of the arabinonucleoside building blocks, is described. The results of these studies were successfully applied to the automated chemical synthesis of the hexanucleotide 5′-aU p aApaUpaApaU p aA-3′. Both solution and solid phase phosphite triester procedures are described. Keywords: arabinonucleotides, arabinophosphoramidites, automated chemical synthesis, protected arabinonucleosides.
Structural studies on the lipid A component of enterobacterial lipopolysaccharides by laser desorption mass spectrometry. Location of acyl groups at the lipid A backbone (1984)

In the present paper laser desorption mass spectrometry (LDMS) was applied to dephosphorylated free lipid A preparations obtained from lipopolysaccharides of Re mutants of Salmonella minnesota, Escherichia coli and Proteus mirabilis. The purpose of this study was to elucidate the location of (R)-3-hydroxytetradecanoic acid and 3-O-acylated (R)-3-hydroxytetradecanoic acid residues which are bound to amino and hydroxyl groups of the glucosamine disaccharide backbone of lipid A. Based on the previous finding from biochemical analyses that the amino group of the nonreducing glucosamine residue (GlcN II) of the backbone carries, in S. minnesota and E. coli, 3-dodecanoyloxytetradecanoic acid and, in P. mirabilis, 3-tetradecanoyloxytetradecanoic acid, a self-consistent interpretation of the LDMS was possible. It was found that: (a) in all three lipids A GlcN II is, besides the amide-linked 3-acyloxyacyl residue, substituted by ester-linked 3-tetradecanoyloxytetradecanoic acid; (b) the reducing glucosamine (GlcN I) is substituted by ester-linked 3-hydroxytetradecanoic acid; (c) the amino group of GlcN I carries a 3-hydroxytetradecanoic acid which is non-acylated in E. coli and which is partially acylated by hexadecanoic acid in S. minnesota and P. mirabilis. In lipids A which were obtained from the P. mirabilis Re mutant grown at low temperature (12 degrees C) LDMS analysis revealed that specifically the one fatty acid bound to the 3-hydroxyl group of amide-linked 3-hydroxytetra-decanoic acid at GlcN II is positionally replaced by delta 9-hexadecenoic acid (palmitoleic acid). It appears, therefore, that enterobacterial lipids A resemble each other in that the 3-hydroxyl groups of the two 3-hydroxytetradecanoic acid residues linked to GlcN II are fully acylated, while those of the two 3-hydroxytetradecanoic acid groups attached to GlcN I are free or only partially substituted.
Gene expression profiling of human breast tissue samples using SAGE-Seq (2010)

We present a powerful application of ultra high-throughput sequencing, SAGE-Seq, for the accurate quantification of normal and neoplastic mammary epithelial cell transcriptomes. We develop data analysis pipelines that allow the mapping of sense and antisense strands of mitochondrial and RefSeq genes, the normalization between libraries, and the identification of differentially expressed genes. We find that the diversity of cancer transcriptomes is significantly higher than that of normal cells. Our analysis indicates that transcript discovery plateaus at 10 million reads/sample, and suggests a minimum desired sequencing depth around five million reads. Comparison of SAGE-Seq and traditional SAGE on normal and cancerous breast tissues reveals higher sensitivity of SAGE-Seq to detect less-abundant genes, including those encoding for known breast cancer-related transcription factors and G protein-coupled receptors (GPCRs). SAGE-Seq is able to identify genes and pathways abnormally activated in breast cancer that traditional SAGE failed to call. SAGE-Seq is a powerful method for the identification of biomarkers and therapeutic targets in human disease.
Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer (2006)

Curcumin (diferuloylmethane) is a dietary phytochemical with low toxicity that exhibits growth-suppressive activity against a variety of cancer cells and possesses certain chemopreventive properties. Curcumin has already been the subject of several clinical trials for use as a treatment in human cancers. Synthetic chemical modifications of curcumin have been studied intensively in an attempt to find a molecule with similar but enhanced properties of curcumin. In this study, a series of novel curcumin analogues were synthesized and screened for anticancer activity. New analogues that exhibit growth-suppressive activity 30 times that of curcumin and other commonly used anticancer drugs were identified. Structurally, the new analogues are symmetrical 1,5-diarylpentadienone whose aromatic rings possess an alkoxy substitution at each of the positions 3 and 5. Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect. The analogues, however, exhibited neither harmful nor growth-suppressive effects on normal hepatocytes where oncogene products are not activated. They also exhibited no toxicities in vivo that they may provide effective alternative therapies for the prevention and treatment of some human cancers.
Determination of molecular orientation of monolayer adsorbates by optical second-harmonic generation (1983)

Optical second-harmonic generation has been used to deduce the average arrangement and orientation of $p$-nitrobenzoic acid molecules adsorbed at air-silica and ethanol-silica interfaces. An adsorption isotherm for the liquid-solid interface has also been obtained.
Visualization of parallel program execution for software behavior analysis and defect detection (2014)

Modern software systems are developed as very complex, heavily parallelized programs. Communication between multiple processes and threads inevitably leads to exponential growth of program state space and nondetermined program behaviour. These facts make standard error detection techniques, such as testing or static analysis, ineffective when applied to parallel programs. One way to solve the error detection problem is dynamic software visualization. In this paper we propose an approach, based on program trace analysis and vizualization. Our prototype allows building program trace logs using code instrumentation and supports 3 visualization types. Experimental results prove that proposed approch is effective and applicable to wide spectrum of software systems.
ChemInform Abstract: Optical Spectroscopic and Structural Properties of V3+‐Doped Fluoride, Chloride, and Bromide Elpasolite Lattices. (1989)

Abstract The crystal structures of the elpasolites (I)‐(VII) are determined by using XRD.
Incomplete Arousal Processes in Infants Who Were Victims of Sudden Death (2003)

Infants who became victims of sudden infant death syndrome (SIDS) aroused less from sleep than control infants. This study was conducted to determine the characteristics of arousal from sleep of infants who eventually died of SIDS. Sixteen infants were monitored some days or weeks before they died of SIDS. Their polygraphic sleep recordings were compared with those of matched control infants. Arousals were scored as subcortical activation (incomplete arousals) or cortical arousal (complete arousals). Cortical arousals were significantly less frequent in the victims who would succumb to SIDS in the future than in the control infants during both REM and non-REM sleep (p = 0.039). The frequency (p = 0.017) and duration (p = 0.005) of subcortical activation were significantly greater in the infants who died of SIDS than in the control infants during REM sleep. Compared with the control infants, the infants who later died of SIDS had more frequent subcortical activation in the first part of the night, between 9:00 P.M. and 12:00 A.M. (p = 0.038), and fewer cortical arousals during the latter part of the night, between 3:00 and 6:00 A.M. (p = 0.011). The present data are suggestive of incomplete arousal processes in infants who eventually died at a time they were presumed to have been asleep.
Engineered substrates for future More Moore and More than Moore integrated devices (2010)

In 1991, M. Bruel (1) invented and patented the Smart Cut technology to fabricate Silicon On Insulator (SOI) substrates. The process relies on the transfer of a high quality single crystal layer from one wafer to another: implantation of gaseous ions in a single crystal wafer, direct bonding on a stiffener and splitting (Fig 1). The invention of this SOI process combined with the entrepreneurship of SOITEC paved the way to high quality SOI substrates mass production. Today, SOI is a mature product (up to 300mm diameter) and now developments are focused on the integration of new materials and functionalities in order to improve device performances and enlarge the application spectrum.
Neuromedin U has a physiological role in the regulation of food intake and partially mediates the effects of leptin (2004)

Intracerebroventricular (ICV) administration of Neuromedin U (NMU), a hypothalamic neuropeptide, or leptin, an adipostat hormone released from adipose tissue, reduces food intake and increases energy expenditure. Leptin stimulates the release of NMU in vitro, and NMU expression is reduced in models of low or absent leptin. We investigated the role of NMU in mediating leptin-induced satiety. ICV administration of anti-NMU immunoglobulin G (IgG) (5 nmol) to satiated rats significantly increased food intake 4 h after injection, an effect seen for </=8 h after injection. ICV administration of NMU (1 nmol) to fasted rats reduced food intake 1 h after injection compared with control, an effect attenuated by pretreatment with anti-NMU IgG. ICV administration of leptin (0.625 nmol) reduced 24-h food intake. This was partially attenuated by the administration of anti-NMU IgG [24 h after onset of dark phase: vehicle, 22.5 +/- 2.0 g; leptin, 13.7 +/- 2.3 g (P < 0.005 vs. vehicle), leptin/NMU IgG, 19.4 +/- 1.3 g (P < 0.05 vs. leptin)]. Intraperitoneal administration of leptin (1.1 mg/kg body wt) reduced 24-h food intake. This was partially attenuated by ICV administration of anti-NMU IgG [24 h after onset of dark phase: vehicle, 31.4 +/- 4.9 g; leptin, 20.8 +/- 2.6 g (P < 0.01 vs. vehicle); leptin/NMU IgG, 28.7 +/- 1.1 g (P < 0.01 vs. leptin)]. These results suggest that NMU plays a physiological role in the regulation of appetite and partially mediates the leptin-induced satiety.
Effect of the Cosurfactant Structure on the Bending Elasticity in Nonionic Oil-in-Water Microemulsions (1998)

Oil-in-water microemulsions of the zwitterionic surfactant tetradecyldimethylamine oxide (TDMAO) that are formed in the presence of various alcohols as cosurfactant have been investigated by means of small-angle neutron scattering and interfacial tension measurements. From these experiments the sum of the bending moduli 2κ + κ has been determined and found to be in the range of 2−5 kT. It is found that the admixture of the alcohol leads to relatively constant values for longer chain alcohols whereas short chain alcohols induce a significant reduction of 2κ + κ that is proportional to the concentration of added alcohol. This behavior of the bending elasticity corresponds to the phase behavior in the ternary systems (TDMAO/alcohol/water) where for the systems with high values for the bending elasticity formation of lamellar phases is observed, whereas for systems of low rigidity bicontinuous isotropic phases are formed with structures that are characterized by a low persistence length.