Handbook of Copper Pharmacology and Toxicology (2002)

Part I. Copper in Mammals Biochemistry and Molecular Biology of Copper in Mammals Maria C. Linder Part II. Copper Proteins Biochemistry of the Wilson's Disease Protein Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. MacArthur, and Hans-Peter Bachinger Biologically Relevant Properties of Copper-Containing Proteins Analyzed by Means of Semiquantitative and Quantitative Theoretical Descriptors, Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, and M. Cristina Menziani Molecular Modeling and Dynamics of Copper Proteins Mattia Falconi and Alessandro Desideri The Prion Protein and Copper: What Is the Connection? Lesley R. Brown and David A. Harris Prion Protein: A Synaptic Cuproprotein David R. Brown Cytochrome-c Oxidase Shinya Yoshikawa The Fet3 Protein: A Multicopper Ferroxidase Essential to Iron Metabolism in Yeast Daniel J. Kosman Interaction of Copper-Binding Proteins from Enteroccus hirae Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, and Charles T. Dameron Part III. Copper Transport Copper Uptake in Eukaryotic Cells Lisbeth Birk Moller and Nina Horn The Role of PINA in Copper Transport, Circadian Rhythms, and Wilson's Disease Jimo Borjigin, Xing Sun, and Michael M. Wang The Identification of Motifs Involved in the Intracellular Trafficking of the Menkes Disease Protein Michael J. Francis and Anthony P. Monaco Intracellular Copper Transport and ATP7B, the Wilson's Disease Protein Kunihiko Terada and Toshihiro Sugiyama A Multicopper Oxidase-Based Iron-Transport System in Yeast Jerry Kaplan Part IV. Molecular Pathogenesis of Diseases of Copper Metabolism Molecular Basis of Diseases of Copper Homeostasis Julian F. B. Mercer, David Kramer, andJames Camakaris Disturbances of Copper Homeostasis and Brain Function Giuseppe Rotilio, Maria Rosa Ciriolo, Maria Teresa Carri, and Luisa Rossi Role of Copper and Other Transition Metal Ions in the Pathogenesis of Parkinson's Disease, Prion Diseases, Familial Amytrophic Lateral Sclerosis and Alzheimer's Disease Gerd Multhaup, Hermann H. Dieter, Konrad Beyreuther, and Thomas A. Bayer Molecular Genetics and Clinical Aspects of Menkes Disease and Occipital Horn Syndrome Hiroko Kodama The Meaning of Alternative Transcripts of the Menkes Disease Gene Edward D. Harris, Manchi C. M. Reddy, and Sudeep Majumdar Expression Profiling in Menkes Disease Zeynep Tumer, Nina Horn, and Lars Riff Jensen Regulation by Copper of the Expression of Human Bis, a New Gene Involved in the Cellular Stress Response to Metals Maria Gabriella Pagliuca, Rosa Lerose, and Arturo Leone Non-Indian Childhood Cirrhosis: Using a Founder Population to Identify the Underlying Genetic Defect Cisca Wijmenga Part V. Copper Toxicity and Therapeutics Biological Effects of Chronic Copper Exposure Magdalena Araya, Mauricio Gonzalez, Manuel Olivares, and Ricardo Uauy Copper Toxicity to Tight Junctions in the Human Intestinal Caco-2 Cell Line Simonetta Ferruzza, Yula Sambuy, Andrea Onetti-Muda, Fabio Nobili, and Maria Laura Scarino Cellular Responses to Copper in Aquatic Organisms: Importance of Oxidative Stress and Alteration of Signal Transduction Aldo Viarengo, Bruno Burlando, and Claudia Bolognesi Selective Removal of Copper Accumulating in the Form Bound to Metallothionein by Tetrathiomolybdate Kazuo T. Suzuki and Yasumitsu Ogra Control of Copper in Wilson's Disease and Diseases of Neovascularization, such as Cancer George J. Brewer Copper-Rich Metallothionein Polymers During the Development of