gebhart/patrepeval huggingface dataset:
Automatic predicate abstraction of C programs (2001)

Model checking has been widely successful in validating and debugging designs in the hardware and protocol domains. However, state-space explosion limits the applicability of model checking tools, so model checkers typically operate on abstractions of systems. Recently, there has been significant interest in applying model checking to software. For infinite-state systems like software, abstraction is even more critical. Techniques for abstracting software are a prerequisite to making software model checking a reality. We present the first algorithm to automatically construct a predicate abstraction of programs written in an industrial programming language such as C, and its implementation in a tool — C2BP. The C2BP tool is part of the SLAM toolkit, which uses a combination of predicate abstraction, model checking, symbolic reasoning, and iterative refinement to statically check temporal safety properties of programs. Predicate abstraction of software has many applications, including detecting program errors, synthesizing program invariants, and improving the precision of program analyses through predicate sensitivity. We discuss our experience applying the C2BP predicate abstraction tool to a variety of problems, ranging from checking that list-manipulating code preserves heap invariants to finding errors in Windows NT device drivers.
A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood (1997)

We have recently described a system for the generation of dendritic cells (DC) and Langerhans cells (LC) from defined CD34+ precursors purified from peripheral blood of healthy adult volunteers. This study has now been extended by the characterization of two distinct subpopulations of CD34+ cells in normal human peripheral blood as defined by the expression of the skin homing receptor cutaneous lymphocyte-associated antigen (CLA). CD34+/CLA+ cells from normal peripheral blood were found to be CD71LOW/CD11a+/CD11b+/CD49d+/CD45RA+ whereas CD34+/CLA- cells displayed the CD71+/CD11aLOW/CD11bLOW/CD49d(+)/ CD45RA(LOW) phenotype. To determine the differentiation pathways of these two cell populations, CD34+ cells were sorted into CLA+ and CLA- fractions, stimulated with GM-CSF and TNF-alpha in vitro, and then were cultured for 10 to 18 d. Similar to unfractionated CD34+ cells, the progeny of both cell populations contained sizable numbers (12-22%) of dendritically shaped, CD1a+/HLA-DR cells. In addition to differences in their motility, the two dendritic cell populations generated differed from each other by the expression of LC-specific structures. Only the precursors expressing the skin homing receptor were found to differentiate into LC as evidenced by the presence of Birbeck granules. In contrast, CLA precursor cells generated a CD1a+ DC population devoid of Birbeck granule-containing LC. Provided that comparable mechanisms as found in this study are also operative in vivo, we postulate that the topographic organization of the DC system is already determined, at least in part, at the progenitor level.
Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings (1999)

Besides its fast excitatory properties, glutamate is known to have neurotoxic properties when released in large amounts or when incompletely recycled. This so-called excitotoxicity is involved in a number of acute and/or degenerative forms of neuropathology such as epilepsy, Alzheimer's, Parkinson's, stroke, and retinal ischemia. In the cochlea, excitotoxicity may occur in two pathological conditions: anoxia and noise trauma. It is characterized by a two-step mechanism: (1) An acute swelling, which primarily depends on the AMPA/kainate type of receptors, together with a disruption of the postsynaptic structures (type I afferent dendrites) resulting in a loss of function. Within the next 5 days, synaptic repair may be observed with a full or a partial (acoustic trauma) recovery of cochlear potentials. (2) The second phase of excitotoxicity, which may develop after strong and/or repetitive injury, consists of a cascade of metabolic events triggered by the entry of Ca2+, which leads to neuronal death in the spiral ganglion. Ongoing experiments in animals, tracking the molecular basis of both these processes, presages the development of new pharmacological strategies to help neurites to regrow and reconnect properly to the IHCs, and to prevent or delay neuronal death in the spiral ganglion. Human applications should follow, and a local (transtympanic) strategy against cochlear excitotoxicity may, in the near future, prove to be helpful in ischemic- or noise-induced sudden deafness, as well as in the related tinnitus.
Metabolism of diacylglycerol in humans. (2007)

Obesity resides upstream of the constituents of metabolic syndromes such as diabetes, hypertension, hyperlipidemia, and arteriosclerosis. Postprandial hyperlipidemia is also implicated in atherogenesis. Therefore, factors that influence the body adiposity and the magnitude of postprandial hyperlipidemia have been intensively investigated. Diacylglycerol (DAG) oil, which is defined to contain DAG 80% (w/w) or greater in the present presentation, is an edible oil with similar taste and usability compared with conventional edible oil rich in TAG. Safety of DAG has been widely evaluated and listed as a GRAS (Generally Recognized as Safe) substance by US FDA. The aim of this review was to summarize the metabolism and nutritional functions of DAG based on the data from scientific journals and conference publications. Effect of DAG ingestion on postprandial elevations of serum lipids was investigated in several dosages, food formula, and in subjects in various conditions. Postprandial triglyceride in serum and the chylomicron fraction are significantly smaller after DAG consumption compared with TAG with a similar fatty acid composition in healthy subjects, and was remarkably reduced in subjects with insulin resistance. Long-term DAG ingestion in controlled diet or free-living condition significantly decreased body adiposity and improved type II diabetic complications. A single dose DAG consumption significantly increased fat oxidation as compared to eucaloric TAG ingestion. DAG oil consumption might be beneficial in reducing the risk factors for lifestyle-related diseases such as obesity, visceral obesity, postprandial hyperlipidemia, insulin resistance, and atherosclerosis.
Incidence, Risk Factors and Prevention Strategies for Work- Related Assault Injuries: A Review of What Is Known, What Needs To Be Known, and Countermeasures for Intervention (1995)

This review organizes available data to address current epidemiological understanding of injuries from workplace assaults. We describe the incidence and general populations at risk for fatal and nonfatal work-related injury, and assess available information on risk factors and countermeasures considered important in reducing injury occurrence. Overall rates of occurrence of workrelated homicides and nonfatal injuries are estimated, and those factors that appear to be consistent across studies are explored. Much of what is known about occupations at high risk for assaults and injuries comes from a small number of documents and special studies within subsets of workplaces. Unfortunately, the potency of specific countermeasures for prevention of violence-related injury in work settings continues to be largely unknown. Numerous fundamental questions remain to be answered: Critical is a full assessment of risk, identification of situations and circumstances amenable to intervention, and evaluations to demonstrate effectiveness.
Synthesis, Characterization, and Application of Novel Polymeric Nanoparticles (2007)

We extended the self-assembly concepts of macromolecules in solutions to create a variety of unique nanosized polymeric core−shell nanoparticles by means which allow scale-up for industrial production. This paper describes the synthesis methods and the mechanisms governing the design of structural features required for a beneficial use as performance-enhancing additives in rubber vulcanizates as well as the performance of such rubber compositions. The nanoparticles were prepared by the polymerization of block copolymers and their self-assembly in solvents into micelles followed by a subsequent stabilization of their structure by core cross-linking. Depending on the type and macrostructure of the block copolymers, the solvent, the concentration, and other process parameters, a variety of core−shell nanoparticles of different shapes (spheres, hollow spheres, ellipsoids, linear and branched strings, etc.) and sizes have been reproducibly synthesized. Most of the nanoparticles were composed of a solid, highly cross-linked core and an elastomeric shell structure. The evolution and structure of the nanoparticles during the different process steps involved were examined and characterized. The unique performance of spherical nanoparticles as performance-enhancing additives and novel reinforcing agents was explored in rubber compounds. It was also shown that the basic spherical or string type nanoparticles can be used as templates for the design of composite structures comprising the basic polymeric nanoparticles and smaller organic, inorganic, or metallic substructures embedded in and attached to the elastomeric shell molecules.
Connecting Programming Environments to Support Ad-Hoc Collaboration (2008)

Physical proximity supports various forms of ad-hoc collaboration among developers such as opportunistic task adaptation and helping co-developers when they are stuck. Connecting the input/output flows of stand-alone programming environments of distributed developers offers the potential to support such collaboration among them. Such a connection has several components including communication sessions, awareness of others' availability and the state of the objects on which they are working, and control channels allowing users to import edits of and share code with others and be notified when a team member has moved away from a program element of interest. It is possible to develop a collaboration-centered design that combines a variety of collaboration streams into a usable and useful user-interface, and implement the design using existing programming environment, communication, and compiler technologies.
An approach for analyzing and correcting spelling errors for non-native Arabic learners (2010)

Spellcheckers are widely used in many software products for identifying errors in users' writings. However, they are not designed to address spelling errors made by non-native learners of a language. As a matter of fact, spelling errors made by non-native learners are more than just misspellings. Non-native learners' errors require special handling in terms of detection and correction, especially when it comes to morphologically rich languages such as Arabic, which have few related resources. In this paper, we address common error patterns made by non-native Arabic learners and suggest a two-layer spell-checking approach, including spelling error detection and correction. The proposed error detection mechanism is applied on top of Buckwalter's Arabic morphological analyzer in order to demonstrate the capability of our approach in detecting possible spelling errors. The correction mechanism adopts a rule-based edit distance algorithm. Rules are designed in accordance with common spelling error patterns made by Arabic learners. Error correction uses a multiple filtering mechanism to propose final corrections. The approach utilizes semantic information given in exercising questions in order to achieve highly accurate detection and correction of spelling errors made by non-native Arabic learners. Finally, the proposed approach was evaluated using real test data and promising results were achieved.
Lethal chylothoraces due to superior vena caval thrombosis in infants (1981)

An unusual etiology, probably iatrogenic, for chylothoraces in the newborn period was recently noted. Three tiny premature infants, all of whom subsequently died, developed massive bilateral chylothoraces. These infants had had prolonged hyperalimentation using jugular central venous catheters for severe gastrointestinal problems and malnutrition. All developed superior vena caval thrombosis, two with overt superior vena caval syndromes. Two had venograms that showed extension of thrombus into the innominate veins to the confluence of the jugular and subclavian veins, at the site of drainage of the lymphatic channels of the thorax. The relationship between superior vena caval an innominate vein thrombosis and chylothoraces in discussed and an important pitfall in the radiologic evaluation is emphasized.
Project SCORE (1960)

This paper is designed to provide a review and summary of the over-all program of development, construction and operation by the U. S. Army Signal Research and Development Laboratory of the first satellite communication system placed in orbit on December 18, 1958. This effort was part of Project SCORE (Signal Communication by Orbiting Relay Experiment) directed by ARPA. Basically, Project SCORE consisted of designing, constructing, and conducting an actual flight experiment of a delayed repeater type satellite package using an actual stripped down Atlas missile as the satellite container. The major points to be covered are summarized in the following paragraphs. A brief historical résumé of the project will cover the preliminary discussions regarding the feasibility of orbiting an Atlas ICBM; the vehicle and weight limitation affecting preliminary system design; mechanical and electrical test problems and ground station installation and on-site training. The system description will cover orbit data; ground station site location and control; airborne equipment components such as antennas, temperature control and communication electronics; general considerations of system design and design problems; ground station equipment including recording and test equipment and associated ground communication equipment.
Antitumor Activity of a Kinesin Inhibitor (2004)

Several members of the kinesin family of microtubule motor proteins play essential roles in mitotic spindle function and are potential targets for the discovery of novel antimitotic cancer therapies. KSP, also known as HsEg5, is a kinesin that plays an essential role in formation of a bipolar mitotic spindle and is required for cell cycle progression through mitosis. We identified a potent inhibitor of KSP, CK0106023, which causes mitotic arrest and growth inhibition in several human tumor cell lines. Here we show that CK0106023 is an allosteric inhibitor of KSP motor domain ATPase with a Ki of 12 nM. Among five kinesins tested, CK0106023 was specific for KSP. In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. KSP was most abundant in proliferating human tissues and was absent from cultured postmitotic neurons. These findings are the first to demonstrate the feasibility of targeting mitotic kinesins for the treatment of cancer.
Synthesis, optical resolution, absolute configuration, and preliminary pharmacology of (+)- and (-)-cis-2,3,3a,4,5,9b-hexahydro-1-methyl-1H-pyrrolo[3,2-h]isoquinoline, a structural analog of nicotine (1993)

Title compound, 8, has been synthesized from isoquinolinone, 1 (an improved preparation for which is presented) and separated into its antipodes with D- and L-di-p-toluoyltartaric acids. These antipodes and the racemic precursor have been evaluated (and found active) in two in vivo systems for their effects. The most potent of the three, (+)-8, has an ED50 of 7.13 mumol/kg for inhibition of spontaneous activity and 7.45 mumol/kg for antinociception compared to 4.44 and 4.81 mumol/kg, respectively, for (S)-(-)-nicotine. Compounds (-)-8 and 7 are about one-fourth as potent. Isomer (+)-8 has the 3aR,9bS configuration, the latter corresponding to (S)-(-)-nicotine as determined by X-ray crystallography. However, (+)-8 failed to compete for [3H]-nicotine binding, and its pharmacological effects were not blocked by mecamylamine. These bridged nicotine analogs either are binding to an as-yet-unidentified nicotinic receptor or they represent a novel class of non-nicotinic analgesics.
Glyceraldehyde-3-phosphate Dehydrogenase, the Putative Target of the Antiapoptotic Compounds CGP 3466 and R-(−)-Deprenyl (1998)

R-(-)-Deprenyl (Selegiline) represents one of the drugs currently used for the treatment of Parkinson's disease. This compound was shown to protect neurons or glias from programmed cell death in a variety of models. The mechanism of action of neuroprotection as well as inhibition of apoptosis remains elusive. CGP 3466 is a structurally related analog of R-(-)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is neuroprotective in the picomolar concentration range. We showed specific binding of CGP 3466 to glyceraldehyde-3-phosphate dehydrogenase by affinity binding, by affinity labeling, and by means of BIAcore(R) technology. Apoptosis assays based on the human neuroblastoma cell line PAJU established the importance of this interaction for mediating drug-induced inhibition of programmed cell death.
MIMO Technologies in 3GPP LTE and LTE-Advanced (2009)

3rd Generation Partnership Project (3GPP) has recently completed the specification of the Long Term Evolution (LTE) standard. Majority of the world's operators and vendors are already committed to LTE deployments and developments, making LTE the market leader in the upcoming evolution to 4G wireless communication systems. Multiple input multiple output (MIMO) technologies introduced in LTE such as spatial multiplexing, transmit diversity, and beamforming are key components for providing higher peak rate at a better system efficiency, which are essential for supporting future broadband data service over wireless links. Further extension of LTE MIMO technologies is being studied under the 3GPP study item "LTE-Advanced" to meet the requirement of IMT-Advanced set by International Telecommunication Union Radiocommunication Sector (ITU-R). In this paper, we introduce various MIMO technologies employed in LTE and provide a brief overview on the MIMO technologies currently discussed in the LTE-Advanced forum.
Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1 (2007)

Several chemotherapeutic drugs in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) result in reversal of resistance to TRAIL-mediated apoptosis through up-regulation of DR5 expression. The promoter of DR5 has one putative binding site for the transcription repressor Yin Yang 1 (YY1), and thus, we hypothesized that the sensitizing drugs may inhibit YY1. We have found that treatment of tumor cells with various chemotherapeutic drugs inhibited nuclear factor-kappaB. We examined whether drugs also inhibit YY1 activity and whether YY1 inhibition correlates with up-regulation of DR5 expression and sensitization of cells to TRAIL-induced apoptosis. The TRAIL- and drug-resistant prostate carcinoma PC-3 cell line was treated with CDDP, VP-16, ADR, and vincristine. DR5 luciferase reporter constructs and small interfering RNA against YY1 were used to determine the role of YY1 in DR5 transcription. Pretreatment of PC-3 cells and other tumor cell lines with various chemotherapeutic drugs sensitized the cells to TRAIL-induced apoptosis concurrently with up-regulation of DR5 expression and inhibition of YY1 expression and its DNA-binding activity. The baseline luciferase activity in PC-3 cells transfected with the wild-type DR5 reporter was significantly augmented in cells transfected with DR5 constructs carrying deletions or mutation in the YY1-binding site. Treatment with drug enhanced DR5 wild-type luciferase activity, with no increase in cells transfected with the YY1-deleted or YY1-mutated constructs. Cells transfected with YY1 small interfering RNA showed up-regulation of DR5 expression and sensitization to TRAIL-mediated apoptosis. The findings provide evidence that drug-induced sensitization of tumor cells to TRAIL is mediated, in part, by inhibition of the transcription repressor YY1 and up-regulation of DR5 expression. Hence, YY1 may be a potential therapeutic target to reverse resistance to TRAIL-induced apoptosis.
Exploring the limits of ultrafast polymerase chain reaction using liquid for thermal heat exchange: A proof of principle (2010)

Thermal ramp rate is a major limiting factor in using real-time polymerase chain reaction (PCR) for routine diagnostics. We explored the limits of speed by using liquid for thermal exchange rather than metal as in traditional devices, and by testing different polymerases. In a clinical setting, our system equaled or surpassed state-of-the-art devices for accuracy in amplifying DNA∕RNA of avian influenza, cytomegalovirus, and human immunodeficiency virus. Using Thermococcus kodakaraensis polymerase and optimizing both electrical and chemical systems, we obtained an accurate, 35 cycle amplification of an 85-base pair fragment of E. coli O157:H7 Shiga toxin gene in as little as 94.1 s, a significant improvement over a typical 1 h PCR amplification.
A survey of techniques for internet traffic classification using machine learning (2008)

The research community has begun looking for IP traffic classification techniques that do not rely on `well known' TCP or UDP port numbers, or interpreting the contents of packet payloads. New work is emerging on the use of statistical traffic characteristics to assist in the identification and classification process. This survey paper looks at emerging research into the application of Machine Learning (ML) techniques to IP traffic classification - an inter-disciplinary blend of IP networking and data mining techniques. We provide context and motivation for the application of ML techniques to IP traffic classification, and review 18 significant works that cover the dominant period from 2004 to early 2007. These works are categorized and reviewed according to their choice of ML strategies and primary contributions to the literature. We also discuss a number of key requirements for the employment of ML-based traffic classifiers in operational IP networks, and qualitatively critique the extent to which the reviewed works meet these requirements. Open issues and challenges in the field are also discussed.