gebhart/patrepeval huggingface dataset:
Identification of a Deubiquitinating Enzyme as a Novel AGS3-Interacting Protein (2010)

Activator of G protein Signaling 3 (AGS3) is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. However, how AGS3 is regulated is little known. We demonstrate here that AGS3 interacts with a ubiquitin specific protease USP9x, and this interaction is at least partially mediated through the C-terminal G protein regulatory domain of AGS3. Knockdown of USP9x causes a moderate reduction in the level of AGS3. In contrast, overexpression of either USP9x or its deubiquitinating domain UCH increases the amount of AGS3, whereas expression of the mutant UCH domain that lacks deubiquitinating activity does not have the same effect. As previously observed in AGS3 knockdown cells, the localization of several marker proteins of the late Golgi compartments is disturbed in cells depleted of USP9x. Taken together, our study suggests that USP9x can modulate the level of a subpopulation of AGS3, and this modulation plays a role in regulating the structure of the late Golgi compartments. Finally, we have found that levels of AGS3 and USP9x are co-regulated in the prefrontal cortex of rats withdrawn from repeated cocaine treatment. In conjunction with the above data, this observation indicates a potential role of USP9X in the regulation of the AGS3 level during cocaine-induced neuroplasticity.
Pipeline control for a single cycle VLSI implementation of a complex instruction set computer (2003)

A description is given of the pipeline control techniques used in the NexGen processor. This processor implements a complex-instruction-set architecture which supports OS/2 applications. The processor achieves single-cycle execution of most instructions, and has numerous hardware accelerators which minimize pipeline penalties and reduce cycle counts for complex instructions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
THE PUBLIC INVOLVEMENT IN PLANNING OF SEACOAST AFFAIRS AT OHSHINDEN AREA, NAKATSU PORT, OITA PREFECTURE (2002)

Public involvement in planning of seacoast affairs is executed in Ohshinden area, Nakatsu Portin Oita Prefecture. Large well-reserved mud flat spreads around the port. People enjoy its scenery andcreatures, and coastal fishery utilizes the ecosystem. The local government and people organize the meeting to discuss utilization and conservation of the seacoast in this area. Comparative consideration on civil engineering works and medical care in terms of informed consent, and the role of local governmentsand function of these meeting are discussed.
Coding constructions for blacklisting problems without computational assumptions (1999)

. We consider the broadcast exclusion problem: how to transmit a message over a broadcast channel shared by N = 2 n users so that all but some specified coalition of k excluded users can understand the contents of the message. Using error-correcting codes, and avoiding any computational assumptions in our constructions, we construct natural schemes that completely avoid any dependence on n in the transmission overhead. Specifically, we construct: (i) (for illustrative purposes,) a randomized scheme where the server&amp;apos;s storage is exponential (in n), but the transmission overhead is O(k), and each user&amp;apos;s storage is O(kn); (ii) a scheme based on polynomials where the transmission overhead is O(kn) and each user&amp;apos;s storage is O(kn); and (iii) a scheme using algebraic-geometric codes where the transmission overhead is O(k 2 ) and each user is required to store O(kn) keys. In the process of proving these results, we show how to construct very good cover-free set systems and co...
Nicotine and its metabolites. Radioimmunoassays for nicotine and cotinine (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNicotine and its metabolites. Radioimmunoassays for nicotine and cotinineJohn J. Langone, Hilda B. Gjika, and Helen Van VunakisCite this: Biochemistry 1973, 12, 24, 5025–5030Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://doi.org/10.1021/bi00748a032RIGHTS & PERMISSIONSArticle Views482Altmetric-Citations309LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (626 KB) Get e-Alerts Get e-Alerts
Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies (1995)

Conventional mouse/mouse or rat/rat hybrid-hybridoma supernatants contain up to 10 different IgG molecules consisting of various combinations of heavy and light chains. Hence, the yield of functional bispecific Ab is low, and purification is often complicated, hampering a general preclinical evaluation of, e.g., bispecific Ab-mediated tumor immunotherapy in animal models. In experiments to overcome this drawback we found that fusion of rat with mouse hybridomas opens the possibility of large scale production of bispecific Ab due to the increased incidence of correctly paired Ab and facilitated purification. In essence, rat/mouse quadroma-derived bispecific Ab have the following advantages: 1) enrichment of functional bispecific Ab because of preferential species-restricted heavy/light chain pairing (observed in four of four rat-mouse quadromas) in contrast to the random pairing in conventional mouse/mouse or rat/rat quadromas, and 2) a possible one-step purification of the quadroma supernatant with protein A. This simple chromatography step does not bind unwanted variants with parental rat/rat heavy chain configuration, and the desired rat/mouse bispecific Ab are retained, which can then easily be separated from parental mouse Ab by sequential pH elution.
A Straightforward, New Method for the Synthesis of Nanocrystalline GaAs and GaP (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Straightforward, New Method for the Synthesis of Nanocrystalline GaAs and GaPShreyas S. Kher and Richard L. WellsCite this: Chem. Mater. 1994, 6, 11, 2056–2062Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/cm00047a027https://doi.org/10.1021/cm00047a027research-articleACS PublicationsRequest reuse permissionsArticle Views1056Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative HIV-1 RNA as a marker of clinical stability and survival in a cohort of 302 patients with a mean CD4 cell count of 300×106/l (1996)

VL > or = or < 35,000 is a better discriminant for progression than a CD4 cell count > or = or < 250 x 10(6)/l. Sequential VL determinations < 60,000 are associated with a better prognosis.
BG9719 (CVT-124), an A 1 Adenosine Receptor Antagonist, Protects Against the Decline in Renal Function Observed With Diuretic Therapy (2002)

In patients with congestive heart failure on standard therapy, including ACE inhibitors, BG9719 increased both urine output and GFR. In these same patients, furosemide increased urine output at the expense of decreased GFR. When BG9719 was given in addition to furosemide, urine volume additionally increased and there was no deterioration in GFR. A1 adenosine antagonism might preserve renal function while simultaneously promoting natriuresis during treatment for heart failure.
DTAM: Dense tracking and mapping in real-time (2011)

DTAM is a system for real-time camera tracking and reconstruction which relies not on feature extraction but dense, every pixel methods. As a single hand-held RGB camera flies over a static scene, we estimate detailed textured depth maps at selected keyframes to produce a surface patchwork with millions of vertices. We use the hundreds of images available in a video stream to improve the quality of a simple photometric data term, and minimise a global spatially regularised energy functional in a novel non-convex optimisation framework. Interleaved, we track the camera's 6DOF motion precisely by frame-rate whole image alignment against the entire dense model. Our algorithms are highly parallelisable throughout and DTAM achieves real-time performance using current commodity GPU hardware. We demonstrate that a dense model permits superior tracking performance under rapid motion compared to a state of the art method using features; and also show the additional usefulness of the dense model for real-time scene interaction in a physics-enhanced augmented reality application.
Convergence behavior of iteratively decoded parallel concatenated codes (2001)

Mutual information transfer characteristics of soft in/soft out decoders are proposed as a tool to better understand the convergence behavior of iterative decoding schemes. The exchange of extrinsic information is visualized as a decoding trajectory in the extrinsic information transfer chart (EXIT chart). This allows the prediction of turbo cliff position and bit error rate after an arbitrary number of iterations. The influence of code memory, code polynomials as well as different constituent codes on the convergence behavior is studied for parallel concatenated codes. A code search based on the EXIT chart technique has been performed yielding new recursive systematic convolutional constituent codes exhibiting turbo cliffs at lower signal-to-noise ratios than attainable by previously known constituent codes.
An assessment of prostatectomy for benign urinary tract obstruction. Geographic variations and the evaluation of medical care outcomes (1988)

IN MAINE, the efforts of practicing urologists to understand how their clinical decisions contribute to the striking variations in rates of prostatectomy from one community to another led to a critical evaluation of the theories under See also pp 3010 and 3018. lying the decision to operate. Specific aspects of our work have been described elsewhere.<sup>1-3</sup>The purpose of this report is to provide an overview of the prostatectomy assessment project—its background and relevance, the methods used, the principal findings and recommendations—and to comment on the applicability of the approach to the evaluation of other common medical practices. <h3>BACKGROUND</h3> The project was an initiative of the Maine Medical Assessment Program,<sup>4,5</sup>an ongoing program sponsored by the Maine Medical Association to respond to the small-area variations in medical practice patterns seen among Maine communities. Striking geographic variations in use are characteristic of many operations, diagnostic procedures, and causes of
A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development (1993)

Substantial regeneration of both the endocrine and exocrine pancreas occurs after a 90% partial pancreatectomy in the young adult rat. We have reported previously that replication of preexisting islet and exocrine cells is enhanced 3- to 4-fold. Here, we report a second pathway of regeneration, that of proliferation and differentiation of precursor cells in the ductal epithelium. As shown with in vivo pulse labeling using 5-bromo-2'-deoxyuridine, an expansion of the ductal epithelium occurs. Proliferation is seen first in the common pancreatic duct and sequentially in smaller ducts of the ductal tree as focal areas of proliferation small ductules form. By 60 h after pancreatectomy, only these focal areas show heavy 5-bromo-2'-deoxyuridine staining. These proliferating ductules comprise 12.8% of the pancreatic volume at 3 days after pancreatectomy but are uncommon at 7 days after pancreatectomy. Coincident with the appearance and disappearance of these regions was a 3.5-fold increased growth of the pancreatic remnant compared with its equivalent of sham animals. These small ductules differentiate into new pancreatic islets and exocrine tissue, forming new lobules of pancreas that are indistinguishable from the preexisting ones. This second pathway of rapid regeneration recapitulates embryonic development in its pattern of ductal proliferation and subsequent differentiation. Furthermore, these studies provide evidence of the presence of precursor/stem cells in the adult pancreas.
Yao & Artusio's Anesthesiology: Problem-Oriented Patient Management, 4th Edition. (1999)

Phillips Professor of AnesthesiologyThe University of Texas Medical BranchGalveston, Texas 77555–0591mzornow@utmb.eduYao &amp; Artusio's Anesthesiology: Problem-Oriented Patient Management, 4th Edition. Edited by Fun-Sun F. Yao. Philadelphia, Lippincott-Raven, 1998. Pages: 1,088 with 98 illustrations. Price:$75.00.Yao and Artusio's 4th edition of Anesthesiology: Problem-Oriented Patient Management represents a unique approach to transferring medical information to the reader. Each chapter starts with a hypothetical surgical case followed by a discussion of the pathophysiology, preoperative evaluation, intraoperative management, and postoperative care of the patient. The format is similar to what is used during the American Board of Anesthesiologists oral examination. The reader has the option of trying to answer the questions without referring to the answers or can read through the questions and answers as if the book were a more conventional text. Although not a primary reference source on anesthesiology, this book will serve admirably for those preparing for their oral board examinations. This reviewer read the book while preparing for his recertification examination and found the concise exposition of common clinical dilemmas in the subspecialties of pain management and obstetrical anesthesiology very useful reviews. This text will also be useful for the practitioner who is confronted with an anesthetic challenge outside of his or her usual range of expertise. In our daily practice, how often are we confronted with a patient with a pheochromocytoma? With thyrotoxicosis? How about an infant with a large cervical mass? Anesthetic considerations for these and 54 additional clinical problems are succinctly addressed in this text.The most recent edition has been expanded to include case discussions of heart and lung transplantation, ischemic heart disease and noncardiac surgery, cancer pain, cerebral aneurysms, nerve blocks of the lower extremity, airway trauma, and anesthesia for magnetic resonance imaging. References in prior editions have been updated to reflect the most current literature and should be easily accessible to those desiring primary sources for additional information. The illustrations consist mostly of line drawings that efficiently depict the crucial information. With a suggested retail price of $75.00, the reader will get a lot of useful information for their dollar. This book will be a valuable addition to the library of both residents in training and established practitioners.
Seed coat-associated invertases of fava bean control both unloading and storage functions: cloning of cDNAs and cell type-specific expression. (1995)

We have studied the molecular physiology of photosynthate unloading and partitioning during seed development of fava bean (Vicia faba). During the prestorage phase, high levels of hexoses in the cotyledons and the apoplastic endospermal space are correlated with activity of cell wall-bound invertase in the seed coat. Three cDNAs were cloned. Sequence comparison revealed genes putatively encoding one soluble and two cell wall-bound isoforms of invertase. Expression was studied in different organs and tissues of developing seeds by RNA gel analysis, in situ hybridization, enzyme assay, and enzyme activity staining. One extracellular invertase gene is expressed during the prestorage phase in the thin-walled parenchyma of the seed coat, a region known to be the site of photoassimilate unloading. We propose a model for an invertase-mediated unloading process during early seed development and the regulation of cotyledonary sucrose metabolism. After unloading from the seed coat, sucrose is hydrolyzed by cell wall-bound invertases. Thus, invertase contributes to establish sink strength in young seeds. The resultant hexoses are loaded into the cotyledons and control carbohydrate partitioning via an influence on the sucrose synthase/sucrose-phosphate synthase pathway. The developmentally regulated degradation of the thin-walled parenchyma expressing the invertase apparently initiates the storage phase. This is characterized by a switch to a low sucrose/hexoses ratio. Feeding hexoses to storage-phase cotyledons in vitro increases the sucrose-phosphate synthase/sucrose synthase ratio and changes carbohydrate partitioning in favor of sucrose. Concomitantly, the transcript level of the major storage product legumin B is downregulated.
Formation of Collisionless High-βPlasmas by Odd-Parity Rotating Magnetic Fields (2007)

Odd-parity rotating magnetic fields (RMFo) applied to mirror-configuration plasmas have produced average electron energies exceeding 200 eV at line-averaged electron densities of approximately 10(12) cm-3. These plasmas, sustained for over 10(3)tauAlfven, have low Coulomb collisionality, vc* triple bond L/lambdaC approximately 10(-3), where lambdaC is the Coulomb scattering mean free path and L is the plasma's characteristic half length. Divertors allow reduction of the electron-neutral collision frequency to values where the RMFo coupling indicates full penetration of the RMFo to the major axis.
Major Depressive Disorder Is Associated With Cardiovascular Risk Factors and Low Omega-3 Index (2010)

Conventional cardiovascular risk factors, the Omega-3 Index, and interleukin-6 levels indicated an elevated cardiovascular risk profile in MDD patients currently free of CVD. Our results support the employment of strategies to reduce the cardiovascular risk in still cardiovascularly healthy MDD patients by targeting conventional risk factors and the Omega-3 Index.
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis (2001)

The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic hedgehog (Shh) is expressed in a layer-specific manner in the perinatal mouse neocortex and tectum, whereas the Gli genes, which are targets and mediators of SHH signaling, are expressed in proliferative zones. In vitro and in vivo assays show that SHH is a mitogen for neocortical and tectal precursors and that it modulates cell proliferation in the dorsal brain. Together with its role in the cerebellum, our findings indicate that SHH signaling unexpectedly controls the development of the three major dorsal brain structures. We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor, inhibits the proliferation of tumor cells. Using the in vivo tadpole assay system, we further show that misexpression of GLI1 induces CNS hyperproliferation that depends on the activation of endogenous Gli1 function. SHH-GLI signaling thus modulates normal dorsal brain growth by controlling precursor proliferation, an evolutionarily important and plastic process that is deregulated in brain tumors.
Stylometric Analysis of Bloggers’ Age and Gender (2009)

We report results of stylometric differences in blogging for gender and age group variation. The results are based on two mutually independent features. The first feature is the use of slang words which is a new concept proposed by us for Stylometric study of bloggers. Slang is a non-dictionary word that has evolved with time due to its frequent and popular usage. For the second feature, we have analysed the variation in average length of sentences across various age groups and gender. These two features are then augmented with previous study results reported in literature for stylometric analysis of age and gender. The combined feature list enhances the accuracy by a remarkable extent in predicting age and gender. These experiments were done on a 20,000 blog corpus. Experimental results show that these features work well in detection of bloggers’ demography. However, gender determination is more accurate than age group detection over a data spread across all ages but the accuracy of age prediction increases if we sample data with remarkable age difference.
The Power of the Pen: Development of Massively Parallel Dip-Pen Nanolithography (2007)

If one had complete control of the architecture of a surface, in terms of composition and physical structure, one could ask and answer some of the most important scientific questions in a wide variety of fields, including surface science, catalysis, and cellular biology. Unfortunately, there are few tools that allow one to tailor surface architecture with such control, and of those that exist, such as electron- and ion-beam lithographies, most are limited in terms of the environment in which they can operate, the materials that can be patterned, cost, and throughput. Toward this end, important new scanning probe technologies have been developed that have impacted fields such as electronics, optics, and medicine.