gebhart/patrepeval huggingface dataset:
Examining the Impact of Team Communication Practices in Innovative Research and Development (R&D) Teams: An Early Findings (2014)

This study was undertaken with the aim of looking at team communication practices amongst innovative research and development (R&D) teams. Innovation in R&D involves the processing and transformation of new knowledge into a commercially viable outcome. Communication is seen as an effective mechanism to translate, share and integrate these new knowledge or information in creating new products or technologies. Therefore, there is an urgent need to understand the role of communication, in this case team communication practices, within innovative R&D teams in explaining its influence on team innovativeness. To achieve the aim, innovative R&D teams from selected public technical universities in Malaysia were identified and selected to participate in this study. Database of these teams was solicited from respective universities’ centre for research innovation and management and relevant bodies managing research and innovation activities within the universities. The literature guided the researchers in identifying, selecting and developing appropriate research instruments utilised in this study. For the purpose of this study, team communication practices (boundary spanning, communication safety, team reflexivity and task communication) will be examined in terms of its influence on team innovativeness. The findings in this paper presented an early insight describing the demographics of the innovative R&D teams in Malaysia. Subsequently, this study also provides an understanding on the impact of team communication practices on R&D team which is vital in explaining the dynamics of team communication of innovative R&D teams. DOI: 10.5901/jesr.2014.v4n4p177
Receptor-mediated folate accumulation is regulated by the cellular folate content. (1986)

Cultured monkey kidney cells are shown to possess a cell-surface receptor that binds 5-methyltetrahydro[3',5',7,9-3H4]folic acid (5-methyltetrahydro[3H]folic acid) with high affinity (Kd = 3 nM at 4 degrees C). The cell-surface binding capacity for [3H]folic acid or [3H]methotrexate is equivalent to that for 5-methyltetrahydro[3H]folate, but the Kd values are 0.4 and 20 nM, respectively. These nonlabeled folates also inhibit cellular binding and accumulation of 5-methyltetrahydro[3H]folate, whereas specific moieties of folic acid (i.e., p-aminobenzoylglutamic acid, pteroic acid, and glutamic acid) had no effect. Surface-bound folate(s) can be released by incubation of the cells at pH 3.5. At 37 degrees C the bound material is slowly transferred into cells, where it becomes resistant to acid release. Within 4 hr the cells internalize about 3-4 times as much folate as is bound to the surface in the steady state. The amount of receptor activity increases markedly when cells are depleted of folate through growth in folate-depleted medium. Binding of folate was inhibited by an antibody raised against a soluble plasma folate-binding protein, suggesting that the cell-surface receptor and the circulating folate-binding protein are immunologically related. These data indicate that cells possess a high-affinity, high-specificity folate receptor whose expression is regulated by the folate content of the cell. They also suggest that a small molecule such as folate can enter cells by receptor-mediated endocytosis.
Effect of Re-17 Mutant Salmonella typhimurium Bacterin Toxoid on Clinical Coliform Mastitis (1994)

The objective of this study was to test the hypothesis that the incidence and severity of clinical coliform mastitis could be decreased by Re-17 mutant Salmonella typhimurium bacterin toxoid. Holstein-Friesian cows from two Arizona dairies were selected for this study based on July through November projected calving dates; peak lactation occurred during the period of highest rainfall and peak environmental stress. The cows were randomly assigned to either a vaccinate or a control group, and 1292 cows were paired by herd, parity, calving date, and milk yield. The 646 vaccinates were injected twice during the third trimester of pregnancy with an Re-17 mutant S. typhimurium bacterin toxoid, and the 646 controls were not vaccinated. Vaccinated cows had significantly fewer clinical cases of coliform mastitis with positive coliform cultures and had lower culling rate from coliform mastitis than control cows during the first 5 mo of lactation. During the same period, the mortality rate from clinical coliform mastitis was 75% less in the vaccinated clinical coliform mastitic group than in the control group. Incidence of mastitis increased with advancing parity. The Re-17 mutant Salmonella typhimurium bacterin toxoid provided cross-protection against coliform mastitis; incidence and severity of clinical coliform mastitis were significantly lowered during the first 5 mo of lactation.
Development of Anti-Infectives Using Phage Display: Biological Agents against Bacteria, Viruses, and Parasites (2012)

The vast majority of anti-infective therapeutics on the market or in development are small molecules; however, there is now a nascent pipeline of biological agents in development. Until recently, phage display technologies were used mainly to produce monoclonal antibodies (MAbs) targeted against cancer or inflammatory disease targets. Patent disputes impeded broad use of these methods and contributed to the dearth of candidates in the clinic during the 1990s. Today, however, phage display is recognized as a powerful tool for selecting novel peptides and antibodies that can bind to a wide range of antigens, ranging from whole cells to proteins and lipid targets. In this review, we highlight research that exploits phage display technology as a means of discovering novel therapeutics against infectious diseases, with a focus on antimicrobial peptides and antibodies in clinical or preclinical development. We discuss the different strategies and methods used to derive, select, and develop anti-infectives from phage display libraries and then highlight case studies of drug candidates in the process of development and commercialization. Advances in screening, manufacturing, and humanization technologies now mean that phage display can make a significant contribution in the fight against clinically important pathogens.
Computer-Integrated Safe Design of FGM Component for Hip Replacement Prosthesis (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Methodology for isolation, identification and characterization of microvesicles in peripheral blood (2011)

This study provides a systematic methodology for MV isolation, identification and quantification, essential for development of MV as diagnostic and prognostic biomarkers of disease.
Expression of periostin in patients with non-small cell lungcancer: correlation with angiogenesis and lymphangiogenesis (2008)

The aim of this study was to evaluate periostin expression measured immunohistochemically in patients with non-small cell lung cancer (NSCLC) and to determine its association with clinical features, prognosis, angiogenesis, and lymphangiogenesis. We investigated periostin expression in a series of 88 patients with NSCLC. We also determined whether expression of periostin correlated with microvessel density and lymphatic microvessel density. Periostin was expressed in 42% of 88 patients. Its expression was significantly correlated with tumor size, lymph node metastasis, disease stage, and lymphatic invasion (p=0.0128, 0.0015, 0.0310 and 0.0273, respectively). There also was a significant relation between periostin expression and microvessel density and lymphatic microvessel density (all p<0.0001). Five-year survival rates were better in patients with negative periostin expression than in those with positive periostin expression (p=0.0044). Periostin expression was not significant in a multivariate additive model. Our findings show that periostin correlates with increased tumor progression and a worse prognosis in NSCLC, as well as with angiogenesis and lymphangiogenesis.
Room Temperature Negative Differential Resistance through Individual Organic Molecules on Silicon Surfaces (2003)

Room temperature negative differential resistance (NDR) has been measured through individual organic molecules on degenerately doped Si(100) surfaces using ultrahigh vacuum scanning tunneling microscopy (STM). For styrene molecules on n-type Si(100), NDR is observed only for negative sample bias because positive sample bias leads to electron stimulated desorption. By replacing styrene with a saturated organic molecule (2,2,6,6-tetramethyl-1-piperidinyloxy), electron stimulated desorption is not observed at either bias polarity. In this case, NDR is observed only for negative sample bias on n-type Si(100) and for positive sample bias on p-type Si(100). This unique behavior is consistent with a resonant tunneling mechanism via molecular orbitals and opens new possibilities for silicon-based molecular electronic devices and chemical identification with STM at the single-molecule level.
Multilabel multiclass classification of OCT images augmented with age, gender and visual acuity data (2018)

Abstract Optical Coherence Tomography (OCT) imaging of the retina is in widespread clinical use to diagnose a wide range of retinal pathologies and several previous studies have used deep learning to create systems that can accurately classify retinal OCT as indicative of one of these pathologies. However, patients often exhibit multiple pathologies concurrently. Here, we designed a novel neural network algorithm that performs multiclass and multilabel classification of retinal images from OCT images in four common retinal pathologies: epiretinal membrane, diabetic macular edema, dry age-related macular degeneration and neovascular age-related macular degeneration. Furthermore, clinicians often also use additional information about the patient for diagnosis. Second contribution of this study is improvement of multiclass, multilabel classification augmented with information about the patient: age, visual acuity and gender. We compared two training strategies: a network pre-trained with ImageNet was used for transfer learning, or the network was trained from randomly initialized weights. Transfer learning does not perform better in this case, because many of the low-level filters are tuned to colors, and the OCT images are monochromatic. Finally, we provide a transparent and interpretable diagnosis by highlighting the regions recognized by the neural network.
Interaction of lipoamide dehydrogenase with the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii (1991)

The interaction between lipoamide dehydrogenase (E3) and dihydrolipoyl transacetylase (E2p) from the pyruvate dehydrogenase complex was studied during the reconstitution of monomeric E3 apoenzymes from Azotobacter vinelandii and Pseudomonas fluorescens. The dimeric form of E3 is not only essential for catalysis but also for binding to the E2p core, because the apoenzymes as well as a monomeric holoenzyme from P. fluorescens, which can be stabilized as an intermediate at 0 degree C, do not bind to E2p. Lipoamide dehydrogenase from A. vinelandii contains a C-terminal extension of 15 amino acids with respect to glutathione reductase which is, in contrast to E3, presumably not part of a multienzyme complex. Furthermore, the last 10 amino acid residues of E3 are not visible in the electron density map of the crystal structure and are probably disordered. Therefore, the C-terminal tail of E3 might be an attractive candidate for a binding region. To probe this hypothesis, a set of deletions of this part was prepared by site-directed mutagenesis. Deletion of the last five amino acid residues did not result in significant changes. A further deletion of four amino acid residues resulted in a decrease of lipoamide activity to 5% of wild type, but the binding to E2p was unaffected. Therefore it is concluded that the C-terminus is not directly involved in binding to the E2p core. Deletion of the last 14 amino acids produced an enzyme with a high tendency to dissociate (Kd approximately 2.5 microM). This mutant binds only weakly to E2p. The diaphorase activity was still high. This indicates, together with the decreased Km for NADH, that the structure of the monomer is not appreciably changed by the mutation. Rather the orientation of the monomers with respect to each other is changed. It can be concluded that the binding region of E3 for E2p is constituted from structural parts of both monomers and binding occurs only when dimerization is complete.
Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells. (1984)

A series of diamine homologues of putrescine and triamine homologues of spermidine was used to determine the structural specificity of the polyamine transport system in ascites L1210 leukemia cells by measuring their ability to compete with [3H]-putrescine, [3H]spermidine, or [3H]spermine for uptake. Transport specificity among the diamines (as indicated by K1 constants) was greatest for those having chain lengths similar to that of spermidine and least for those similar to putrescine. Among the triamines, transport specificity was greatest for those having an overall chain length similar to those of spermidine and spermine. The homologue competition profiles were relatively the same for [3H]putrescine, [3H]spermidine, or [3H]spermine, suggesting that all three polyamines utilize the same transport system. This was further substantiated by uptake kinetic plots which showed that the three polyamines were competitive inhibitors of one another. In terms of receptor specificity, the ranking order among the polyamines was as follows: spermine (apparent Km, 1.6 microM) greater than spermidine (apparent Km, 2.2 microM) greater than putrescine (apparent Km, 8.5 microM). This information should prove useful in designing anticancer agents which are intended to utilize this transport system.
A Study of Vertebra and Disc Geometric Relations of the Human Cervical and Lumbar Spine (1986)

Geometric configuration and dimensions of the human vertebra were investigated using x-ray photographs of 157 normal, healthy men. A simplified model of the vertebra in the midsagittal plane is presented and used as a basis for measurements. Geometric considerations and statistical analysis served for correlating significant measurements of vertebral bodies and intervertebral disks of the human spine.
The IBM Smart Surveillance System (2004)

The increasing need for sophisticated surveillance systems and the move to digital surveillance infrastructure has transformed surveillance into a large scale data analysis and management challenge. Smart surveillance systems use automatic image understanding techniques to extract information from the surveillance data. While the majority of the research and commercial systems have focused on the information extraction aspect of the challenge, very few systems have explored the use of extracted information in the search, retrieval, data management and investigation context. The IBM Smart Surveillance Systems demonstrates the capabilities of a fully integrated smart surveillance system, where the index data generated by the analytics is made searchable in real time.
Nghiên cứu ứng dụng các bài tập nâng cao hiệu quả kỹ thuật di chuyển cho nam sinh viên chuyên sâu cầu lông Trường Đại học Đồng Tháp (2015)

Qua nghiên cứu đã lựa chọn được 4 bài tập đánh giá năng lực di chuyển của nam sinh viên chuyên sâu cầu lông có đủ độ tin cậy và tính thông báo. Từ đó ứng dụng được các bài tập đã lựa chọn vào việc nâng cao hiệu quả kỹ thuật di chuyển cho nam sinh viên chuyên sâu cầu lông Trường Đại học Đồng Tháp mang lại kết quả tốt.
Immunoblot analysis of serological responses in invasive aspergillosis. (1985)

The serological response to Aspergillus fumigatus was investigated in patients with pulmonary aspergillosis using the immunoblot technique. Antibody was detected against nine components of the fungus, ranging in molecular weight from 88 000 to 33 000 daltons. Antibody to a 40 000 dalton component was present in most patients (13 of 16). In surviving patients it was high (two with aspergilloma) or low but persistent (two with invasive aspergillosis). It was absent or fell in the 12 patients who died of invasive aspergillosis. Antibody to this 40 000 dalton antigen was not present in 10 sera from healthy controls. This antigen may form the basis of a more sensitive and specific serodiagnostic test for systemic aspergillosis.
Activation of Nur77 by Selected 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes Induces Apoptosis through Nuclear Pathways (2005)

Nur77 is an orphan receptor and a member of the nerve growth factor-I-B subfamily of the nuclear receptor family of transcription factors. Based on the results of transactivation assays in pancreatic and other cancer cell lines, we have now identified for the first time Nur77 agonists typified by 1,1-bis(3-indolyl)-1-(p-anisyl)methane that activate GAL4-Nur77 chimeras expressing wild-type and the ligand binding domain (E/F) of Nur77. In Panc-28 pancreatic cancer cells, Nur77 agonists activate the nuclear receptor, and downstream responses include decreased cell survival and induction of cell death pathways, including tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and poly(ADP-ribose) polymerase (PARP) cleavage. Moreover, the transactivation and apoptotic responses are also induced in other pancreatic, prostate, and breast cancer cells that express Nur77. In Panc-28 cells, small inhibitory RNA for Nur77 reverses ligand-dependent transactivation and induction of TRAIL and PARP cleavage. Nur77 agonists also inhibit tumor growth in vivo in athymic mice bearing Panc-28 cell xenografts. These results identify compounds that activate Nur77 through the ligand binding domain and show that ligand-dependent activation of Nur77 through nuclear pathways in cancer cells induces cell death and these compounds are a novel class of anticancer agents.
Two-Center German Experience with Aortic Endografting (1997)

Endoluminal repair of infrarenal AAAs using straight or bifurcated grafts is a feasible alternative to conventional surgical repair. Longer follow-up and more experience with refined endograft models will elucidate the durability of this endovascular approach to treating AAAs.
Repair of Strand Breaks by Homologous Recombination (2013)

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.
Base-Calling of Automated Sequencer Traces UsingPhred. I. Accuracy Assessment (1998)

The availability of massive amounts of DNA sequence information has begun to revolutionize the practice of biology. As a result, current large-scale sequencing output, while impressive, is not adequate to keep pace with growing demand and, in particular, is far short of what will be required to obtain the 3-billion-base human genome sequence by the target date of 2005. To reach this goal, improved automation will be essential, and it is particularly important that human involvement in sequence data processing be significantly reduced or eliminated. Progress in this respect will require both improved accuracy of the data processing software and reliable accuracy measures to reduce the need for human involvement in error correction and make human review more efficient. Here, we describe one step toward that goal: a base-calling program for automated sequencer traces, phred, with improved accuracy. phred appears to be the first base-calling program to achieve a lower error rate than the ABI software, averaging 40%-50% fewer errors in the data sets examined independent of position in read, machine running conditions, or sequencing chemistry.
Aspirin Use and Incidence of Large-Bowel Cancer in a California Retirement Community (1991)

substantial modifications in breast cancer incidence trends.
U.S.-Canada softwood lumber trade disputes and lumber price volatility (2001)

This paper uses analysis of variance (ANOVA) and regression analysis to study U.S. softwood lumber price volatility between 1980 and 2000, the period that coincides with several episodes of U.S.-Canada softwood lumber trade disputes. The results show that softwood lumber prices were more volatile in the 1990s than in the 1980s, with the period between 1991 to 1996 being the most volatile, the period covered by the 1996 U.S.-Canada Softwood Lumber Trade Agreement (SLA) being the second most volatile, and the period covered by the U.S.-Canada Memorandum of Understanding being the least volatile. Uncertainty, supply constraints due to the SLA and declining availability of federal timber in the western United States, and variations in housing starts were the primary causes of price volatility in the 1990s. The results of this paper have implications on resolving the U.S.-Canada softwood lumber trade disputes.
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model. (2002)

We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.
Gender differences in response to differing antidepressant drug classes: two negative studies (2003)

As few studies have examined for differential gender and age effects in response to narrow action and broad action antidepressant drugs across major depressive subtypes, gender differential effects remain to be established.