gebhart/patrepeval huggingface dataset:
Glucose transport rate and glycogen synthase activity both limit skeletal muscle glycogen accumulation (2002)

We varied rates of glucose transport and glycogen synthase I (GS-I) activity (%GS-I) in isolated rat epitrochlearis muscle to examine the role of each process in determining the rate of glycogen accumulation. %GS-I was maintained at or above the fasting basal range during 3 h of incubation with 36 mM glucose and 60 μU/ml insulin. Lithium (2 mM LiCl) added to insulin increased glucose transport rate and muscle glycogen content compared with insulin alone. The glycogen synthase kinase-3β inhibitor GF-109203x (GF; 10 μM) maintained %GS-I about twofold higher than insulin with or without lithium but did not increase glycogen accumulation. When %GS-I was lowered below the fasting range by prolonged incubation with 36 mM glucose and 2 mU/ml insulin, raising rates of glucose transport with bpV(phen) or of %GS-I with GF produced additive increases in glycogen concentration. Phosphorylase activity was unaffected by GF or bpV(phen). In muscles of fed animals, %GS-I was ∼30% lower than in those of fasted rats, and insulin-stimulated glycogen accumulation did not occur unless %GS-I was raised with GF. We conclude that the rate of glucose transport is rate limiting for glycogen accumulation unless %GS-I is below the fasting range, in which case both glucose transport rate and GS activity can limit glycogen accumulation.
Double standards (1996)

High Performance Fortran (HPF) does not allow efficient expression of mixed task/data-parallel computations or the coupling of separately compiled data-parallel modules. In this paper, we show how a coordination library implementing the Message Passing Interface (MPI) can be used to represent these common parallel program structures. This library allows data-parallel tasks to exchange distributed data structures using calls to simple communication functions. We present microbenchmark results that characterize the performance of this library and that quantify the impact of optimizations that allow reuse of communication schedules in common situations. In addition, results from two-dimensional FFT, convolution, and multiblock programs demonstrate that the HPF/MPI library can provide performance superior to that of pure HPF. We conclude that this synergistic combination of two parallel programming standards represents a useful approach to task parallelism in a data-parallel framework, increasing the range of problems addressable in HPF without requiring complex compiler technology.
Suppression of early T-cell–receptor-triggered cellular activation by the Janus kinase 3 inhibitor WHI-P-154 (2003)

These data indicate that pharmacologic targeting of JAK3 uncouples early TCR-triggered signaling from essential downstream events, which may have important implications for the use of such compounds in T-cell-mediated disorders such as allograft rejection or graft-versus-host disease.
Utility of Intracardiac Echocardiography in Left Heart Ablation for Tachyarrhythmias (2007)

Catheter-based radiofrequency ablation in the left heart can provide effective therapy for tachyarrhythmias. The recent development of the real time intracardiac echocardiography (ICE) with 2D and Doppler color flow imaging can facilitate left heart ablation procedures. This report reviews the use of ICE during radiofrequency catheter ablation procedures for atrial fibrillation (AF) and ventricular tachycardia and is based on our own experience in 955 patients. ICE has a critical role for guiding transseptal catheterization, assisting placement of mapping/ablation catheters and monitoring lesion morphologic changes, especially in the pulmonary vein ostia, Marshall ligament region, thickened interatrial septum, left atrial posterior wall contiguous to esophagus, aortic valve cusps, and the epicardial regions. One of the more powerful utilities of ICE lies in its ability to identify and potentially reduce procedural complications including damage to intracardiac structures, residual atrial septal defect, left atrial thrombus formation, pulmonary vein stenosis, esophageal injury, myocardial air-embolization and pericardial effusion during left heart ablation.
Septal accessory pathway: anatomy, causes for difficulty, and an approach to ablation. (2010)

Accessory pathway (AP) ablation is one of the most satisfying invasive electrophysiology procedures associated with high success rates and relatively few complications. Nevertheless, when APs are found on the cardiac septum, ablative procedures become complex, and unique pitfalls need to be avoided.These difficulties with septal ablation are magnified in the pediatric population. The relatively small heart, rapid nodal conduction, and proximity of the arterial system specifically complicate septal ablation in children. The electrophysiologist must use every tool in his or her armamentarium, including exact delineation of pathway location, identification of pathway potentials, detection of the presence of pathway slant, etc. In addition, an exact knowledge of the complex anatomy of the cardiac septum, including the posteroseptal space, the aortic cusp region, and the proximity of the AV conduction system and coronary vessels, becomes mandatory.In this review, we describe the developmental anatomy and regional anatomy of septal accessory pathways. We then discuss approaches to map specific to pathways in particularly problematic regions at or near the septum, including venous and aortic cusp related accessory pathways.
Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes (2009)

Antibody mimic proteins (AMPs) are polypeptides that bind to their target analytes with high affinity and specificity, just like conventional antibodies, but are much smaller in size (2-5 nm, less than 10 kDa). In this report, we describe the first application of AMP in the field of nanobiosensors. In(2)O(3) nanowire based biosensors have been configured with an AMP (Fibronectin, Fn) to detect nucleocapsid (N) protein, a biomarker for severe acute respiratory syndrome (SARS). Using these devices, N protein was detected at subnanomolar concentration in the presence of 44 microM bovine serum albumin as a background. Furthermore, the binding constant of the AMP to Fn was determined from the concentration dependence of the response of our biosensors.
Electrooptic mapping of near-field distributions in integrated microwave circuits (1998)

A field mapping system based on external electrooptic sampling has been developed in order to determine the vectorial components of the electric near-field distribution within microwave integrated circuits. The capabilities of the setup are demonstrated by two-dimensional measurements of normal and tangential fields in a coplanar microwave distribution network at frequencies up to 15 GHz. Results obtained on a functioning power-distribution network, as well as on two nonfunctioning networks, show the ability of the technique to interrogate internal circuit operation and to isolate faults through investigation of the field distributions.
On Supporting Kleene Closure over Event Streams (2008)

Complex event patterns involving Kleene closure are finding application in a variety of stream environments for tracking and monitoring purposes. In this paper, we propose a compact language, SASE+, that can be used to define a wide variety of Kleene closure patterns, analyze the expressive power of the language, and outline an automata-based implementation for efficient Kleene closure evaluation over event streams.
Resistance to Bacillus thuringiensis Affects Mating Success of the Diamondback Moth (Lepidoptera: Plutellidae) (1993)

In laboratory choice tests, males from a colony of diamondback moth, Plutella Xylostella (L.), resistant to Bacillus thuringiensis Berliner toxins mated fewer times than did males from a susceptible colony. Resistant and susceptible males did not differ in mating duration or ability to mate first with virgin females. Thus, the mating deficiency of resistant males was caused by reduced success in obtaining subsequent matings. Reduced mating success of resistant males is a fitness cost that may contribute to loss of resistance in the absence of exposure to toxins. Resistant females mated as frequently as susceptible females, suggesting that no change in female mating success was associated with resistance. We found no evidence for assortative mating between resistant and susceptible moths that would diminish the effectiveness of refuges in resistance management.
Spinal Cord Implantation with Acidic Fibroblast Growth Factor as a Treatment for Root Avulsion in Obstetric Brachial Plexus Palsy (2005)

Nerve root avulsion carries the worst prognosis among brachial plexus injuries and remains a great challenge for surgeons to repair. In this case, a boy with complete avulsion of the left-side C6 root presented with flaccid paralysis of the left arm after birth. As there was no significant spontaneous recovery, the patient underwent operation when he was 6 months old. One end of the nerve graft from the sural nerve was anastomosed with the avulsed C6 root, and the other end was implanted into the ventrolateral aspect of the spinal cord with fibrin glue containing acidic fibroblast growth factor. After 2 years of follow-up, there has been significant improvement in motor function and in electrophysiologic studies over the left upper limb.
The reciprocal exclusion by L-dopa (L-3,4-dihydroxyphenylalanine) and L-tyrosine of their incorporation as single units into a soluble rat brain protein (1975)

Several compounds, structurally and metabolically related to phenylalanine and tyrosine, were tested for their effects on the incorporations of phenylalanine and tyrosine as single units into a protein of the soluble subcellular fraction of rat brain. Of the compounds tested, only L-dopa (L-3,4-dihydroxyphenylalanine) inhibited these incorporations. Further, L-dopa was incorporated into a protein of the same fraction in such a way that it excluded the incorporation of tyrosine as a single unit. Conversely, tyrosine inhibited and excluded the incorporation of L-dopa. The incorporation of L-dopa required ATP (apparent Km = 0.23mM), KCl (apparent Km = 20mM) and MgCl2 (optimal concentration range, 5-16mM). These requirements were similar to those previously determined for the incorporation of tyrosine and phenylalanine. The inactivation rate of the enzymic systems for L-tyrosine and L-dopa incorporations, when kept at 37 degrees C, was the same for both amino acids (half-life = 80 min). It is suggested that the acceptor for the incorporation of dopa is the same as that for the incorporation of tyrosine.
Clinical Trials in Traumatic Brain Injury (1997)

Many compounds have now been tested that were expected to ameliorate the secondary ischemic brain damage after severe head injury. Thus far, none of these have been clearly successful. This review is an attempt to identify factors that could be responsible for some of these failures. Recommendations are made that could help to avoid these pitfalls in the future. The usefulness and criteria for use of animal models for traumatic brain injury to depict human head injury are discussed. Clearly, it has now become widely accepted that mechanism-driven trials, in which individual pathophysiological mechanisms are targeted, are preferable in this heterogeneous patient population. Other factors, such as the effect of brain penetration, safety and tolerability of the compound, and the interface between the pharmaceutical industry and academics are a major influence in the success of these trials. Furthermore, different ways of analyzing trials such as sequential analysis and newer, alternative end points should be considered. Pharmacological agents will never be the "magic bullet" for a process as heterogenous in pathophysiological mechanisms as traumatic brain injury. This does not imply that the role of neuroprotective compounds will not be important in the future. New approaches in developing, conducting and analyzing these expensive clinical trials must be devised in the future.
[Osteomalacia as an apparently rare side effect of oral fumaric acid therapy. Secondary DeToni-Debré Fanconi syndrome in the adult]. (1992)

A case of fully reversible tubular toxicity with consecutive metabolic osteopathy following systemic fumaric acid therapy is reported. This secondary effect of oral fumaric acid therapy obviously occurs very rarely, never having been described before. A 46-year-old female patient with a long history of recurrent palmoplantar psoriasis underwent oral treatment with fumaric acid and its esters in accordance with the Schäfer method, preceding attempts at curative treatment with conventional antipsoriatic agents having proved unsatisfactory. Two months later, the patient started to experience arthralgia, back pain in the early hours of the morning and myalgia with increasing frequency, progressing to disablement in moving and walking and, finally, to total immobility. Not until 9 months later was the reason for these severe disabilities found: they stemmed from hypophosphataemic osteomalacia as a result of a complex disturbance of the renal tubular system. The clinical symptoms and the results of laboratory chemistry tests returned to normal as soon as fumaric acid medication was discontinued. Two attempts at reexposure confirmed the causal relationship. Oral fumaric acid medication should never be administered without clinical and chemical controls.
Evidence for Redox Regulation of Cytochrome c Release during Programmed Neuronal Death: Antioxidant Effects of Protein Synthesis and Caspase Inhibition (2001)

Sympathetic neurons die by apoptosis when they are deprived of nerve growth factor (NGF). Activation of caspases by cytochrome c released from mitochondria is central to this death. In this report we present evidence that cellular redox state regulates cytochrome c redistribution in these neurons. An increase of mitochondrial-produced reactive oxygen species (ROS) occurred in rat sympathetic neurons in cell culture within 3 hr of NGF withdrawal. Caspase inhibitors blocked this ROS burst. By 6 hr after NGF deprivation, glutathione (GSH) levels had increased, neutralizing elevated hydrogen peroxide levels and returning cellular redox state to basal levels. By 12 hr after deprivation, ROS levels had again increased and remained elevated during the rest of the apoptotic process. The later ROS burst appeared to have both caspase-dependent and caspase-independent components and was coincident with the period of cytochrome c release. Inhibition of protein synthesis with cycloheximide (CHX) and treatment with the antioxidant compound, N-acetyl-l-cysteine (l-NAC), blocked both the early and late ROS bursts by increasing cellular GSH levels (Ratan et al., 1994; Tan et al., 1998). Both compounds, and a membrane-permeant form of GSH, also inhibited cytochrome c release and death. Treatment of NGF, CHX-, l-NAC-, and GSH-saved cells with hydrogen peroxide caused rapid cytochrome c release. These data suggest a role for cellular redox state in regulating cytochrome c release during apoptosis induced by NGF withdrawal.
Capital games (1999)

This article looks forward to how public-private partnerships might be utilised to deliver the new integrated services outlined in the recent White Papers.
Effects of Sodium Bicarbonate Ingestion on Anaerobic Performance: A Meta-Analytic Review (1993)

Many researchers have investigated the effects of induced metabolic alkalosis, by ingestion of sodium bicarbonate, on anaerobic exercise performance. But the results have been inconsistent and often contradictory. The purpose of this review was to synthesize the varied findings using a meta-analytic approach. Twenty-nine investigations met our inclusion criteria. Results show that NaHCO3 ingestion clearly results in a more alkaline extracellular environment. The dosage, however, was only moderately related to the increase in pH and HCO3-. Overall, performance was enhanced but the range of effect sizes was large, -0.12 to 2.87. In studies that measured time to exhaustion, there was a mean 27 +/- 20% increase in duration. The treatment effect, however, was only weakly related to the degree of induced alkalosis. But in comparing the 19 studies that showed a positive treatment effect with the 16 that showed no effect, the former were associated with a greater increase in pH following ingestion of a somewhat larger dosage, and a greater decrease in pH with exercise.
Integrated CMOS transmit-receive switch using LC-tuned substrate bias for 2.4-GHz and 5.2-GHz applications (2004)

CMOS transmit-receive (T/R) switches have been integrated in a 0.18-μm standard CMOS technology for wireless applications at 2.4 and 5.2 GHz. This switch design achieves low loss and high linearity by increasing the substrate impedance of a MOSFET at the frequency of operation using a properly tuned LC tank. The switch design is asymmetric to accommodate the different linearity and isolation requirements in the transmit and receive modes. In the transmit mode, the switch exhibits 1.5-dB insertion loss, 28-dBm power, 1-dB compression point (P<sub>1dB</sub>), and 30-dB isolation, at 2.4 and 5.2 GHz. In the receive mode, the switch achieves 1.6-dB insertion loss, 11.5-dBm P<sub>1dB</sub>, and 15-dB isolation, at 2.4 and 5.2 GHz. The linearity obtained in the transmit mode is the highest reported to date in a standard CMOS process. The switch passes the 4-kV Human Body Model electro-static discharge test. These results show that the switch design is suitable for narrow-band applications requiring a moderate-high transmitter power level (&lt; 1 W).
Purification and Characterization of a GDP-fucose:Polypeptide Fucosyltransferase from Chinese Hamster Ovary Cells (1998)

A GDP-fucose:polypeptide fucosyltransferase was purified 5000-fold to homogeneity from Chinese hamster ovary cell extracts in the absence of detergent. The purification procedure included two affinity chromatographic steps using the acceptor substrate, a recombinant factor VII EGF-1 domain, and the donor substrate analog, GDP-hexanolamine, as ligands. The purified enzyme migrates as a single band of 44,000 daltons on SDS-polyacrylamide gel electrophoresis and is itself a glycoprotein with more than one high mannose type oligosaccharide chain with a total molecular weight of 4000. The Km values for factor VII EGF-1 domain and GDP-fucose are 15 and 6 microM, respectively. The Vmax is 2.5 micromol.min-1.mg-1. The presence of 50 mM Mn2+ increased the enzyme activity 17-fold, but Mn2+ was not absolutely required, since the enzyme exhibited some activity even in the presence of EDTA. The acceptor substrate specificity was studied using site-directed mutagenesis of human factor IX EGF domain. Only one of several differently folded species could serve as acceptor substrate, although they all had the same molecular weight as determined by liquid chromatography on-line with mass spectrometry. This indicates that the enzyme requires proper folding of the epidermal growth factor domain for its activity.
Limitations of reverse-transcriptase polymerase chain reaction analyses for detection of micrometastatic epithelial cancer cells in bone marrow. (1997)

Limiting factors in the detection of micrometastatic tumor cells by RT-PCR are (1) the illegitimate transcription of tumor-associated or epithelial-specific genes in hematopoietic cells, and (2) the deficient expression of the marker gene in micrometastatic tumor cells.
Activation of WNT / β-Catenin Signaling in Pulmonary Fibroblasts by TGF-β1 Is Increased in Chronic Obstructive Pulmonary Disease (2011)

β-catenin signaling contributes to ECM production by pulmonary fibroblasts and contributes to myofibroblasts differentiation. WNT/β-catenin pathway expression and activation by TGF-β₁ is enhanced in pulmonary fibroblasts from individuals with COPD. This suggests an important role of the WNT/β-catenin pathway in regulating fibroblast phenotype and function in COPD.
Preparation of Polycrystalline TiO2 Photocatalysts Impregnated with Various Transition Metal Ions:  Characterization and Photocatalytic Activity for the Degradation of 4-Nitrophenol (2001)

A set of polycrystalline TiO2 photocatalysts loaded with various ions of transition metals (Co, Cr, Cu, Fe, Mo, V, and W) were prepared by using the wet impregnation method. The samples were characterized by using some bulk and surface techniques, namely X-ray diffraction, BET specific surface area determination, scanning electron microscopy, point of zero charge determination, and femtosecond pump−probe diffuse reflectance spectroscopy (PP-DRS). The samples were employed as catalysts for 4-nitrophenol photodegradation in aqueous suspension, used as a probe reaction. The characterization results have confirmed the difficulty to find a straightforward correlation between photoactivity and single specific properties of the powders. Diffuse reflectance measurements showed a slight shift in the band gap transition to longer wavelengths and an extension of the absorption in the visible region for almost all the doped samples. SEM observation and EDX measurements indicated a similar morphology for all the particles, and a not homogeneous distribution of the metal species onto the surface of catalyst particles. The impregnated samples revealed recombination rates always higher than that of bare TiO2. The photoactivity of TiO2 was reduced by the presence of transition metal ions with the exception of W, which instead played a beneficial role. The results of femtosecond pump−probe diffuse reflectance spectroscopy appear quite in accord with the observed photocatalytic activity only for the lowest values of electron−hole recombination rate of the samples.
Evaluation of a worksite injury and illness prevention program: Do the effects of the REACH OUT training program reach the employees? (1997)

In this article the authors report the findings of a 2-year study evaluating the effectiveness of REACH OUT, a train-the-trainer program developed to assist small businesses comply with California legislation, Senate Bill 198 (1989), requiring employees to implement a worksite Injury and Illness Prevention Program. Data from a case study sample of 8 companies, drawn from 151 Southern California small businesses participating in the larger study, are reported. Diagnostic walk-throughs were performed, and employee surveys collected at the case study companies approximately 2 months before the treatment group received the intervention and again 1 year later. Results indicate that greater corporate compliance led to employees' perceptions of increased health and safety meetings and training sessions, which led to greater employee health and safety knowledge and improved employee health outcomes.
Holistic Sentiment Analysis Across Languages: Multilingual Supervised Latent Dirichlet Allocation (2010)

In this paper, we develop multilingual supervised latent Dirichlet allocation (MlSLDA), a probabilistic generative model that allows insights gleaned from one language's data to inform how the model captures properties of other languages. MlSLDA accomplishes this by jointly modeling two aspects of text: how multilingual concepts are clustered into thematically coherent topics and how topics associated with text connect to an observed regression variable (such as ratings on a sentiment scale). Concepts are represented in a general hierarchical framework that is flexible enough to express semantic ontologies, dictionaries, clustering constraints, and, as a special, degenerate case, conventional topic models. Both the topics and the regression are discovered via posterior inference from corpora. We show MlSLDA can build topics that are consistent across languages, discover sensible bilingual lexical correspondences, and leverage multilingual corpora to better predict sentiment.