gebhart/patrepeval huggingface dataset:
Considerations of the Impedance Method, Wave Propagation, and Wireless Systems for Structural Health Monitoring (2004)

The research presented in this thesis is all based on the impedance method for structural health monitoring. The impedance method is an electro-mechanical technique which utilizes a single piezoelectric transducer as both a sensor and actuator. Due to the high frequencies of excitation used for the method, the sensing area for damage detection can be very localized. Previous work has shown that wave propagation can be added to systems already equipped with hardware for impedance-based structural health monitoring. The work in this thesis shows what happens under varying temperature conditions for a structure being monitored with wave propagation. A technique to compensate for temperature fluctuations is also presented. \nThe work presented here is an initial study to directly correlate the actual amount of damage in a composite specimen with a damage metric indicated by impedance-based structural health monitoring. Two different damage mechanisms are examined: transverse matrix cracking and edge delamination. With both composite defects, a sample is interrogated with the impedance method before and after damage is introduced. The exact amount of damage in each specimen is found using radiography and compared with the health monitoring results. \nTraditional impedance techniques require the use of a bulky and expensive impedance analyzer. With the trend of structural health monitoring moving towards unobtrusive sensors which can be permanently placed on a structure, an impedance analyzer does not lend itself to these small, low power consuming requirements. In this thesis, an initial attempt to miniaturize the hardware is described. A prototype impedance-based structural health monitoring system, incorporating wireless based communications, is fabricated and validated with experimental testing on a number of different structures. The first steps towards a complete self-contained, robust structural health monitoring sensor are presented.
Differential immune responses to α-gal epitopes on xenografts and allografts: implications for accommodation in xenotransplantation (2000)

Xenograft recipients produce large amounts of high-affinity anti-Gal IgG in response to Galalpha1-3Galbeta1- 4GlcNAc-R (alpha-gal) epitopes on the graft. In contrast, ABO-mismatched allograft recipients undergo "accommodation," a state of very weak immune response to ABO antigens. These differences in anti-carbohydrate immune response were studied in alpha1,3galactosyltransferase knock-out mice. Pig kidney membranes administered to these mice elicited extensive production of anti-Gal IgG, whereas allogeneic kidney membranes expressing alpha-gal epitopes elicited only a weak anti-Gal IgM response. Anti-Gal IgG response to xenograft membranes depended on helper T cell activation and was inhibited by anti-CD40L antibody. These T cells were activated by xenopeptides and not by alpha-gal epitopes. Moreover, allogeneic cell membranes manipulated to express xenoproteins also induced anti-Gal IgG response. Xenoglycoproteins with alpha-gal epitopes are processed by anti-Gal B cells. Xenopeptides presented by these cells activate a large repertoire of helper T cells required for the differentiation of anti-Gal B cells into cells secreting anti-Gal IgG. Alloglycoproteins with alpha- gal epitopes have very few immunogenic peptides and fail to activate helper T cells. Similarly, ineffective helper T-cell activation prevents a strong immune response to blood group antigens in ABO-mismatched allograft recipients, thus enabling the development of accommodation.
Distinct Hemostatic Profile of Leukocytes in Essential Thrombocythemia (ET) Carrying the JAK2 V617F Mutation. (2005)

Abstract The pathogenesis of the thrombotic diathesis of patients with ET is not completely clarified. Activation of polymorphonuclear leukocyte (PMN) occurs in these patients and is associated with a hypercoagulable state and increased number of circulating platelet/PMN aggregates. Further, increased procoagulant Tissue Factor (TF) expression in ET PMN is also reported. Recently, a gain-of-function JAK2 mutation (V617F) has been described in a high proportion of bcr/abl-negative myeloproliferative disorders. Specifically, in subjects with ET the mutation is present in about 50% of cases and retrospective data suggest an association with a higher rate of complications, including thrombosis. Aim of this study was to evaluate whether ET patients carrying the JAK2 mutation possess PMN with different hemostatic characteristics compared to ET subjects without JAK2 mutation and healthy controls. Twenty ET patients, 10 with and 10 without JAK2 mutation (median age: 50 years, range 32–61; platelet count: median 782 x 109/L, range 474–1,565 x 109/L), not receiving cytoreductive therapy (classified as low risk group), were included in the study; 16 age matched healthy subjects acted as controls. Expression of CD11b, TF and fibrinogen on PMN surface as well as PMN-platelet mixed aggregates (defined as the percentage of CD11b-positive PMN co-expressing a platelet-specific marker, i.e. CD42b or CD62P) were evaluated by whole blood flow-cytometry in both basal condition and after in vitro PMN stimulation by f-MLP. In washed isolated PMN samples the level of TF-mRNA was determined by RT-PCR. In basal conditions, significantly (p&amp;lt;0.01) increased levels of PMN/platelet aggregates (both CD42 and CD62P pos. PMN) compared to controls were found, independently from JAK2 mutation. Differently, PMN from JAK2 mutation carriers expressed significantly higher surface TF (18.2±9 %pos. cells) and fibrinogen (12.3±7 %pos. cells) antigens compared to non-carrier (TF: 11.6±5 %; fibrinogen: 7.2±2 %pos. cells) and control subjects (TF: 11.1±3 %; fibrinogen: 7.1±3 %pos. cells). In vitro stimulation with f-MLP increased the proportion of platelet/PMN aggregates (CD11b/CD42 and CD11b/CD62P) in all ET patients and controls. However, in JAK2 mutation carriers the levels of both CD62P and CD42b positive PMN were significantly greater than those of non-carrier ET patients and controls (p&amp;lt;0.05). Similarly, TF and fibrinogen levels on stimulated PMN surface were more elevated in the JAK2 mutation positive group compared to both the mutation negative and control groups. The analysis of PMN TF-mRNA showed a significantly higher expression in the whole ET patient group compared to controls, independently from the presence of JAK2 mutation. In conclusions, these data indicate that the expression of JAK2 mutation in ET patients may confer to PMN a different hemostatic phenotype in terms of increased interaction with platelets and increased expression of surface TF and fibrinogen, suggesting a new link of this mutation with a prothrombotic status.
A flexible light-directed DNA chip synthesis gated by deprotection using solution photogenerated acids (2001)

Oligonucleotide microarrays or oDNA chips are effective decoding and analytical tools for genomic sequences and are useful for a broad range of applications. Therefore, it is desirable to have synthesis methods of DNA chips that are highly flexible in sequence design and provide high quality and general adoptability. We report herein, DNA microarray synthesis based on a flexible biochip method. Our method simply uses photogenerated acid (PGA) in solution to trigger deprotection of the 5'-OH group in conventional nucleotide phosphoramidite monomers (i.e. PGA-gated deprotection), with the rest of the reactions in the synthesis cycle the same as those used for routine synthesis of oligonucleotides. The complete DNA chip synthesis process is accomplished on a regular DNA synthesizer that is coupled with a UV-VIS projection display unit for performing digital photolithography. Using this method, oDNA chips containing probes of newly discovered genes can be quickly and easily synthesized at high yields in a conventional laboratory setting. Furthermore, the PGA-gated chemistry should be applicable to microarray syntheses of a variety of combinatorial molecules, such as peptides and organic molecules.
gamma Heavy chain disease in man: cDNA sequence supports partial gene deletion model. (1982)

Human gamma heavy chain disease (HCD) is characterized by the presence in serum of a short monoclonal Ig gamma chain unattached to light chains. Although most HCD proteins have internal deletions, in some the defect is NH2-terminal. The OMM gamma 3 HCD serum protein is of the latter type, having undergone an extensive NH2-terminal deletion with a sequence starting within the hinge. A cell line synthesizing the OMM protein has enabled us to study the biogenesis of the abnormal molecule. In vitro translation of isolated mRNA yields a protein containing a hydrophobic NH2-terminal leader sequence. In the intact cell, the precursor molecule is processed normally to yield a protein with an NH2-terminal sequence homologous to the beginning of the variable (V) region. The nucleotide sequence of cDNA prepared from the OMM mRNA encodes a 19-amino acid leader followed by the first 15 residues of the V region. An extensive internal deletion encompasses the remainder of the V and the entire CH1 domain. Immediately following the short V region, there is information in the cDNA for the entire normal hinge. The primary synthetic product is thus an internally deleted molecule that undergoes postsynthetic degradation to yield the NH2-terminally deleted serum protein. The structure of the OMM mRNA suggests that the protein abnormality results from a partial gene deletion rather than defective splicing.
Achromatic wave plates for optical pickup units fabricated by use of imprint lithography (2005)

We report achromatic form-birefringence wave plates for optical pickup units. Material dispersion and structure dispersion are balanced in a rigorous multilayer design. A trilayer grating using SiN(x)/SiO(y)N(z)/SiO2 provides easily accessible process control points and relaxed fabrication tolerance. We demonstrate precise patterning by using nanoimprint lithography on UV-curable polymers, alleviating a major fabrication challenge. The achromatic wave plates exhibit 90+/-3 degrees retardance and >95% transmittance as measured by a Mueller matrix method at wavelengths of 640-800 nm.
Characterization of early molecular sex differentiation in rainbow trout, Oncorhynchus mykiss (2007)

Abstract Early differentiation in rainbow trout gonads was investigated by expression profiling and in situ hybridization (ISH). Expression of cyp19a1 and fst in females and sox9a1 in males were sexually dimorphic between 32 to 35 days post‐fertilization (dpf). After 35 dpf, the differentiation proceeded with sexually dimorphic profiles for sox9a2, dmrt1, cyp11b2.1, amh in males and foxl2a, foxl2b, hsd3b1, inha in females. cyp17a1, cyp11a1, star, nr5a1b increased only after 40 dpf in both sexes with a slightly higher expression in females. cyp19a1 expression was localized in a cluster of somatic cells in the ventral side of female gonads, and sox9a2 and amh in somatic cells surrounding the germ cells, at 28 dpf and thereafter, both in male and female gonads. cyp11b2.1, cyp17a1 , and cyp11a1 expressions were only detected in scattered somatic cells in males after 46 dpf. This confirms the early implication of cyp19a1 in trout ovarian differentiation and suggests that early testicular differentiation does not need androgen production. Developmental Dynamics 236:2198–2206, 2007. © 2007 Wiley‐Liss, Inc.
Antibiotic therapy for ocular infection. (1994)

Infections of the eye can rapidly damage important functional structures and lead to permanent vision loss or blindness. Broad-spectrum antibiotics should be administered to the appropriate site of infection as soon as a diagnosis is made. Topical drops are preferred for corneal and conjunctival infections. Intravitreal antibiotics, and possibly subconjunctival and parenteral antibiotics, are preferred for endophthalmitis. Parenteral antibiotics are recommended for infection in deep adnexal structures. We review specific aspects of antibiotic therapy for ocular and periocular infection.
Drug‐specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions (2016)

We found a higher risk of HP with FCM administration when compared to ISM administration. Conversely, we found a higher risk of mild HSRs with ISM administration when compared to FCM administration. The impacts of the two types of side effects should be considered when choosing an IV iron drug.
Biology and treatment of Burkittʼs lymphoma (2007)

Burkitt's lymphoma is an interesting mature B-cell non-Hodgkin's lymphoma that has numerous distinct features and clinical variants depending on factors such as geographical location, immunological status and patient's age. Although the role of the MYC oncogene has been well studied, we are only now appreciating the defining molecular characteristics of this disease, and using these advances to improve treatment options for patients.
Plant chitinases--regulation and function. (2003)

The aim of this review is to present the current state of knowledge on plant chitinases and their regulation and function. Chitinases are up-regulated by a variety of stress conditions, both biotic and abiotic, and by such phytohormones as ethylene, jasmonic acid, and salicylic acid. Like other PR proteins, chitinases play a role in plant resistance against distinct pathogens. Moreover, by reducing the defence reaction of the plant, chitinases allow symbiotic interaction with nitrogen-fixing bacteria or mycorrhizal fungi. However, recent investigations have shown that these enzymes are also involved in numerous physiological events. The involvement of chitinases in development and growth processes is also described.
A Low-Noise Solid-State Nanopore Platform Based on a Highly Insulating Substrate (2014)

A solid-state nanopore platform with a low noise level and sufficient sensitivity to discriminate single-strand DNA (ssDNA) homopolymers of poly-A40 and poly-T40 using ionic current blockade sensing is proposed and demonstrated. The key features of this platform are (a) highly insulating dielectric substrates that are used to mitigate the effect of parasitic capacitance elements, which decrease the ionic current RMS noise level to sub-10 pA and (b) ultra-thin silicon nitride membranes with a physical thickness of 5 nm (an effective thickness of 2.4 nm estimated from the ionic current) are used to maximize the signal-to-noise ratio and the spatial depth resolution. The utilization of an ultra-thin membrane and a nanopore diameter as small as 1.5 nm allow the successful discrimination of 40 nucleotide ssDNA poly-A40 and poly-T40. Overall, we demonstrate that this platform overcomes several critical limitations of solid-state nanopores and opens the door to a wide range of applications in single-molecule-based detection and analysis.
Functional basis for complement evasion by staphylococcal superantigen-like 7 (2010)

The human pathogen Staphylococcus aureus has a plethora of virulence factors that promote its colonization and survival in the host. Among such immune modulators are staphylococcal superantigen-like (SSL) proteins, comprising a family of 14 small, secreted molecules that seem to interfere with the host innate immune system. SSL7 has been described to bind immunoglobulin A (IgA) and complement C5, thereby inhibiting IgA-FcαRI binding and serum killing of Escherichia coli. As C5a generation, in contrast to C5b-9-mediated lysis, is crucial for immune defence against staphylococci, we investigated the impact of SSL7 on staphylococcal-induced C5a-mediated effects. Here, we show that SSL7 inhibits C5a generation induced by staphylococcal opsonization, slightly enhanced by its IgA-binding capacity. Moreover, we demonstrate a strong protective activity of SSL7 against staphylococcal clearance in human whole blood. SSL7 strongly inhibited the C5a-induced phagocytosis of S. aureus and oxidative burst in an in vitro whole-blood inflammation model. Furthermore, we found that SSL7 affects all three pathways of complement activation and inhibits the cleavage of C5 by interference of its binding to C5 convertases. Finally, SSL7 effects were also demonstrated in vivo. In a murine model of immune complex peritonitis, SSL7 abrogated the C5a-driven influx of neutrophils in mouse peritoneum.
Embryonic stem cells and islet replacement in diabetes mellitus (2004)

Transplantation of functional islets of Langerhans may emerge as a useful therapy for some patients with type 1 diabetes mellitus (DM), but donor islet shortages motivate the search for new sources of transplantable islets. Pluripotent embryonic stem (ES) cells are expandable in culture and have the potential to give rise to all cell types in the body. The recent isolation of pluripotent ES cells from humans has generated excitement over the possibility of engineering glucose-responsive islet replacement tissue from these cells in large quantities. In this study, we review the recent advances in generating insulin-producing cells (IPC) from mouse and human ES (hES) cells.
Plutonium solution in Concentration Range from 8 to 17 G/liter (2023)

This paper very briefly discusses the need for a fundamental criticality study of low concentrations of plutonium solutions. Examples of the occurrence of such solutions, which are characteristic of waste, are cited. Due to the prevalence of decontaminating and decommissioning activities, low concentration solutions are expected to become an important concern. Technical deficiencies in previous calculations are also discussed as a reason for performing low concentration criticality studies.
Substrate specificity of uridine and purine nucleoside phosphorylases of the Escherichia coli whole cells (1988)

Изучена субстратная специфичность уридинфосфорилазы и пуриннуклеозидфосфорилазы в составе целых клеток Е. coli БМ-11 на примере фосфоролиза ряда аналогов уридина и синтеза соответствующих аналогов аденозина. Показано, что наиболее существенные изменения активности указанных ферментов вызывают модификации при С-3'-атоме углеводного фрагмента уридина и аналогичные изменения в структуре рибофуранозо-1- фосфата.
Charting the Fate of the “Good Cholesterol”: Identification and Characterization of the High-Density Lipoprotein Receptor SR-BI (1999)

Risk for cardiovascular disease due to atherosclerosis increases with increasing concentrations of low-density lipoprotein (LDL) cholesterol and is inversely proportional to the levels of high-density lipoprotein (HDL) cholesterol. The receptor-mediated control of plasma LDL levels has been well understood for over two decades and has been a focus for the pharmacologic treatment of hypercholesterolemia. In contrast, the first identification and characterization of a receptor that mediates cellular metabolism of HDL was only recently reported. This receptor, called scavenger receptor class B type I (SR-BI), is a fatty acylated glycoprotein that can cluster in caveolae-like domains on the surfaces of cultured cells. SR-BI mediates selective lipid uptake from HDL to cells. The mechanism of selective lipid uptake is fundamentally different from that of classic receptor-mediated endocytic uptake via coated pits and vesicles (e.g. the LDL receptor pathway) in that it involves efficient receptor-mediated transfer of the lipids, but not the outer shell proteins, from HDL to cells. In mice, SR-BI plays a key role in determining the levels of plasma HDL cholesterol and in mediating the regulated, selective delivery of HDL-cholesterol to steroidogenic tissues and the liver. Significant alterations in SR-BI expression can result in cardiovascular and reproductive disorders. SR-BI may play a similar role in humans; thus, modulation of its activity may provide the basis of future approaches to the treatment and prevention of atherosclerotic disease.
Multicenter clinical perspectives on a broadband infrared light device for skin tightening. (2006)

Modalities for skin tightening include radiofrequency (RF) energy, lasers, and combination RF and diode lasers. A new broadband infrared light device (BILD) (Titan, Cutera, Inc, Brisbane, CA) targets water to achieve dermal heating and collagen remodeling for skin tightening. Although thousands of procedures have been performed worldwide with this device, only one article (to the author's knowledge) describing its performance in skin tightening has been published. Three US dermatologists report their experience with and provide their perspective on facial skin tightening with the BILD system. As early adopters, they each have 12 to 18 months experience with this system. One author (A.F.T.) treated 42 patients twice at 1-month intervals over 18 months. The mean improvement score was 1.83 (scale 0 to 4, with 4 denoting maximum improvement) with an average follow-up time of 3.7 months. More than 90% of treated patients showed visible improvement. No complications were observed and patient satisfaction was high. This paper presents the general consensus of the authors on patient selection and treatment protocol, their modifications of the manufacturer's treatment protocol, and the outcomes of 42 patients treated by one author (A.F.T.). The observations were gathered separately and turned out to be very similar. The recommendations are presented to help practitioners achieve consistently good results and avoid complications with the BILD procedure.
Application of seismic wave field attributes in reservoir characterization (1989)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1989Application of seismic wave field attributes in reservoir characterizationAuthors: Lars SonnelandOlav BarkvedMorten OlsenGary SnyderLars SonnelandGECO A.S., Norway, Olav BarkvedGECO A.S., Norway, Morten OlsenGECO A.S., Norway, and Gary SnyderGECO A.S., Norwayhttps://doi.org/10.1190/1.1889781 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1889781FiguresReferencesRelatedDetailsCited ByHigh-dimensional co-occurrence matrix: A new tool for 3D seismic target visualization and interpretationQiang Luo, Yibo Wang, Yikang Zheng, Xu Chang, Baodeng Wang, and Rongshu Zeng26 October 2020 | Interpretation, Vol. 8, No. 4Sand fraction prediction from seismic attributes using optimized support vector regression in an oil reservoir6 February 2020 | Earth Science Informatics, Vol. 13, No. 2An application of seismic attributes analysis for mapping of gas bearing sand zones in the sawan gas field, Pakistan21 December 2015 | Acta Geodaetica et Geophysica, Vol. 51, No. 4References26 September 2016Evolution of seismic interpretation during the last three decadesSatinder Chopra and Kurt J. Marfurt16 July 2012 | The Leading Edge, Vol. 31, No. 61. Overview of Seismic Attributes21 March 2012Seismic attributes — A historical perspectiveSatinder Chopra and Kurt J. Marfurt14 September 2005 | GEOPHYSICS, Vol. 70, No. 5Amplitude interpretation of three‐dimensional reflection dataMichael E. Enachescu10 February 2005 SEG Technical Program Expanded Abstracts 1989ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1989 Pages: 1375 publication data© 1989 Copyright © 1989 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 10 Feb 2005 CITATION INFORMATION Lars Sonneland, Olav Barkved, Morten Olsen, and Gary Snyder, (1989), "Application of seismic wave field attributes in reservoir characterization," SEG Technical Program Expanded Abstracts : 813-817. https://doi.org/10.1190/1.1889781 Plain-Language Summary PDF DownloadLoading ...