gebhart/patrepeval huggingface dataset:
Pulse rate estimation using imaging photoplethysmography: generic framework and comparison of methods on a publicly available dataset (2018)

Objective: to establish an algorithmic framework and a benchmark dataset for comparing methods of pulse rate estimation using imaging photoplethysmography (iPPG). Approach: first we reveal essential steps of pulse rate estimation from facial video and review methods applied at each of the steps. Then we investigate performance of these methods for DEAP dataset www.eecs.qmul.ac.uk/mmv/datasets/deap/ containing facial videos and reference contact photoplethysmograms. Main results: best assessment precision is achieved when pulse rate is estimated using continuous wavelet transform from iPPG extracted by the POS method (overall mean absolute error below 2 heart beats per minute). Significance: we provide a generic framework for theoretical comparison of methods for pulse rate estimation from iPPG and report results for the most popular methods on a publicly available dataset that can be used as a benchmark.
Initiation of insulin glargine therapy in type 2 diabetes subjects suboptimally controlled on oral antidiabetic agents: results from the AT.LANTUS trial* (2008)

This study shows that initiation of once-daily glargine with OADs results in significant reduction of HbA(1c) with a low risk of hypoglycaemia. The greater reduction in HbA(1c) was seen in patients randomized to the patient-driven algorithm (algorithm 2) on 1 or >1 OAD.
Polarization-preserving wavefront reversal by four-wave mixing in photoanisotropic materials (1988)

A method of polarization (vector) wavefront reversal by four-wave mixing in a photoanisotropic material is described. Jones matrices, describing the dynamic holographic gratings recorded in the material at arbitrary polarization of the signal wave, are derived. They are employed to define the conditions for generating a wave that is fully conjugate (by polarization as well) to the signal wave. The way to achieving these conditions by optically controlling the anisotropy of the nonlinear medium is demonstrated experimentally.
Relationship between low- and high-affinity glucose transport systems of Saccharomyces cerevisiae (1988)

The high-affinity glucose transport process in Saccharomyces cerevisiae whole cells was regulated by catabolite repression and inactivation. The low-affinity process was constitutive, and its activity was inhibited in proportion to the extent of derepression of the high-affinity process. The latter finding suggests that there is some regulatory relationship between the two processes.
A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer. (2000)

Our review suggests that improvements can be made to more effectively report the results of these FDG PET studies. The overall values determined through the meta-analysis indicate the potential benefits of using FDG PET as a diagnostic or management tool. Furthermore, these values should prove to be useful to assess the cost-effectiveness of using FDG PET in the management of patients with recurrent CRC.
Acute ischaemic preconditioning protects against skeletal muscle infarction in the pig (1995)

The protective effect of preconditioning can be induced in pig skeletal muscle but at a higher threshold than reported previously in pig cardiac muscle (one cycle). Preconditioning of pig skeletal muscle is associated with a lower energy metabolism during sustained ischaemia. At the present time, it is not known if this energy sparing effect is a major mechanism of ischaemic preconditioning against infarction in skeletal muscles.
Rapid Profiling of Soybean Aromatic Compounds Using Electronic Nose (2019)

Soybean (<i>Glycine max</i> (L.)) is the world's most important seed legume, which contributes to 25% of global edible oil, and about two-thirds of the world's protein concentrate for livestock feeding. One of the factors that limit soybean's utilization as a major source of protein for humans is its characteristic soy flavor. This off-flavor can be attributed to the presence of various chemicals such as phenols, aldehydes, ketones, furans, alcohols, and amines. In addition, these flavor compounds interact with protein and cause the formation of new off-flavors. Hence, studying the chemical profile of soybean seeds is an important step in understanding how different chemical classes interact and contribute to the overall flavor profile of the crop. In our study, we utilized the HERCALES Fast Gas Chromatography (GC) electronic nose for identification and characterization of different volatile compounds in five high-yielding soybean varieties, and studied their association with off-flavors. With aroma profiling and chemical characterization, we aim to determine the quantity and quality of volatile compounds in these soybean varieties and understand their effect on the flavor profiles. The study could help to understand soybean flavor characteristics, which in turn could increase soybean use and enhance profitability.
Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease (2002)

sVAP-1 serum concentrations are not significantly different in IBD and healthy control subjects. sVAP-1 serum levels are of no value in the assessment of disease activity or severity of inflammation in patients with IBD.
ELISpot for measuring human immune responses to vaccines (2011)

The enzyme-linked immunosorbent spot (ELISpot) assay is one of the most commonly used methods to measure antigen-specific T cells in both mice and humans. Some of the primary reasons for the popularity of the method are that ELISpot is highly quantitative, can measure a broad range of magnitudes of response and is capable of assessing critical cellular immune-related activities such as IFN-γ secretion and granzyme B release. Furthermore, ELISpot is adaptable not only to the evaluation of a variety of T-cell functions, but also to B cells and innate immune cells. It is no wonder that ELISpot has evolved from a research tool to a clinical assay. Recent Phase I and II studies of cancer vaccines, tested in a variety of malignancies, have suggested that ELISpot may be a useful biomarker assay to predict clinical benefit after therapeutic immune modulation. This article will discuss the most common applications of ELISpot, overview the efforts that have been undertaken to standardize the assay and apply the method in the analysis of human clinical trials, and describe some important steps in the process of developing a clinical-grade ELISpot.
On the mechanism of acoustic droplet vaporization (2003)

It has been observed in the past that micrometer sized droplets can be vaporized into gas bubbles by the application of diagnostic ultrasound. This paper will discuss the possible underlying mechanism of acoustic droplet vaporization (ADV) including acoustic cavitation, acoustic heating, shape oscillations during acoustic irradiation, and hydrodynamic cavitation. Experiments were performed on droplet emulsions as well as on single droplets. The vaporization of emulsions was quantified based on gas bubbles generated in a flow tube using a 10 MHz linear imaging army. Single droplets were monitored optically under a microscope and a high speed video system. The frequency dependence of ADV as well as trials with degassed water (40% of saturation) imply that acoustic cavitation is not the mechanism for ADV. Acoustic heating was investigated by exposing the droplet emulsion to repetitive tone bursts (50 Hz to 5 kHz). No significant change in pressure threshold for ADV was observed, however the yield of gas bubbles was used to calculate the single pulse conversion efficiency of ADV to 26%. Droplet shape oscillations causing a non-uniform Laplace pressure, were found to be 15% or less of the droplet diameter. They could be observed at the beginning and at the end of the acoustic irradiation. Observed was a dipole-type motion (1.3 /spl mu/m amplitude) of irradiated droplets as well as the spot-like onset of vaporization on the axis of oscillation close to a pole of the droplet. It is concluded that because of the high Reynolds number during ADV (4-5/spl times/10/sup 5/), the mechanism of vaporization might be based on hydrodynamic effects.
Positive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-γ (2001)

Similar to myeloid dendritic cells, murine macrophages and macrophage cell lines were found to express a surface receptor for IL-12. As a result, peritoneal macrophages could be primed by IL-12 to present an otherwise poorly immunogenic tumor peptide in vivo. Using binding analysis and RNase protection assay, we detected a single class of high affinity IL-12 binding sites (K(d) of approximately 35 pM) whose number per cell was increased by IFN-gamma via up-regulation of receptor subunit expression. Autocrine production of IL-12 was suggested to be a major effect of IL-12 on macrophages when the cytokine was tested alone or after priming with IFN-gamma in vitro. In vivo, combined treatment of macrophages with IFN-gamma and IL-12 resulted in synergistic effects on tumor peptide presentation. Therefore, our findings suggest a general and critical role of IL-12 in potentiating the accessory function of myeloid APC.
Perceived Importance of the Quality of the Indoor Environment in Commercial Buildings (2007)

Recognition of the importance of the quality of the indoor environment (IEQ) to health, comfort and productivity of building end users has produced increasing numbers of voluntary schemes whose assessment embraces a wide spectrum of environmental attributes. Studies which aim to derive appropriate weighting factors for these attributes through soliciting the perceived importance from experts are abundant. This article reports the findings of a study which, based on face-to-face interviews with 548 end users and 66 building professionals, processed their perceived importance of IEQ using the analytical hierarchy process (AHP). Attributes included were thermal comfort, air cleanliness, odor and noise associated with the air conditioning system of typical commercial buildings. Correlation analysis of the ranking results of the AHP weights revealed the difference in perceived importance of the attributes according to gender of the respondents. Other factors also found to have influence on the perceived importance of the IEQ were whether the respondents were professionals or other end users and the reason for them working or visiting the buildings and the duration of their stay. These all varied with psychophysical factors such as personal experiences, needs and expectations. Further work is needed to study whether the weighting factors should be derived from the perceptions of experts, end users, or a balance between the two.
Carotenoid Biosynthesis in Photosynthetic Bacteria (1989)

Carotenoids are photoprotective pigments present in many photosynthetic and nonphotosynthetic organisms. The desaturation of phytoene into phytofluene is an early step in the biosynthetic pathway that in the photosynthetic bacterium Rhodobacter capsulatus is mediated by the product of the crtI gene. Here we report the sequence of this gene and the identification of CrtI as a membrane protein of approximate Mr 60,000. Mutant strains with 5-fold lower or 10-fold higher levels of CrtI with respect to wild type have only small differences in their carotenoid content, indicating that the cellular concentration of CrtI is not a limiting factor in carotenoid biosynthesis. However, a correlation was found between the levels of CrtI and the formation of a photosynthetic antenna system.
Organic-inorganic electronics (2001)

Organic-inorganic hybrid materials enable the integration of useful organic and inorganic characteristics within a single molecular-scale composite. Unique electronic and optical properties have been observed, and many others can be envisioned for this promising class of materials. In this paper, we review the crystal structures and physical properties of one family of crystalline, self-assembling, organic-inorganic hybrids based on the layered perovskite framework. In addition to exhibiting a number of potentially useful properties, the hybrids can be deposited as thin films using simple and inexpensive techniques, such as spin coating or single-source thermal ablation. The relatively new field of “organic-inorganic electronics” offers a variety of exciting technological opportunities. Several recent demonstrations of electronic and optical devices based on organic-inorganic perovskites are presented as examples.
Cationic ruthenium allenylidene complexes as a new class of performing catalysts for ring closing metathesis (1998)

Cationic allenylidene ruthenium complexes [Ru CCCR2(L)(Cl)(arene)]PF6 (L = PCy3, PPri3), easily prepared from RuCl2(L)(p-cymene), prop-2-yn-1-ol and NaPF6, are found to be excellent catalyst precursors for ring closing olefin metathesis.
Collagen Fibril Orientation in Ovine and Bovine Leather Affects Strength: A Small Angle X-ray Scattering (SAXS) Study (2011)

There is a large difference in strength between ovine and bovine leather. The structure and arrangement of fibrous collagen in leather and the relationship between collagen structure and leather strength has until now been poorly understood. Synchrotron based SAXS is used to characterize the fibrous collagen structure in a series of ovine and bovine leathers and to relate it to tear strength. SAXS gives quantitative information on the amount of fibrous collagen, the orientation (direction and spread) of the collagen microfibrils, and the d-spacing of the collagen. The amount of collagen varies through the thickness of the leather from the grain to the corium, with a greater concentration of crystalline collagen measured toward the corium side. The orientation index (OI) is correlated strongly with strength in ovine leather and between ovine and bovine leathers. Stronger leather has the fibrils arranged mostly parallel to the plane of the leather surface (high OI), while weaker leather has more out-of-plane fibrils (low OI). With the measurement taken parallel to the animal's backbone, weak (19.9 N/mm) ovine leather has an OI of 0.422 (0.033), stronger (39.5 N/mm) ovine leather has an OI of 0.452 (0.033), and bovine leather with a strength of (61.5 N/mm) has an OI of 0.493 (0.016). The d-spacing profile through leather thickness also varies according to leather strength, with little variation being detected in weak ovine leather (average=64.3 (0.5) nm), but with strong ovine leather and bovine leather (which is even stronger) exhibiting a dip in d-spacing (from 64.5 nm at the edges dropping to 62 nm in the center). This work provides a clear understanding of a nanostructural characteristic of ovine and bovine leather that leads to differences in strength.
Expression of Wnt-5a Is Correlated with Aggressiveness of Gastric Cancer by Stimulating Cell Migration and Invasion (2006)

Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in the Wnt signaling. Although abnormal activation of beta-catenin-dependent pathway is often observed in human cancer, the relationship between beta-catenin-independent pathway and tumorigenesis is not clear. We sought to clarify how Wnt-5a is involved in aggressiveness of gastric cancer. Abnormal expression of Wnt-5a was observed in 71 of 237 gastric cancer cases by means of immunohistochemistry. The positivity of Wnt-5a expression was correlated with advanced stages and poor prognosis of gastric cancer. Wnt-5a had the abilities to stimulate cell migration and invasion in gastric cancer cells. Wnt-5a activated focal adhesion kinase and small GTP-binding protein Rac, both of which are known to play a role in cell migration. Cell migration, membrane ruffling, and turnover of paxillin were suppressed in Wnt-5a knockdown cells. Furthermore, anti-Wnt-5a antibody suppressed gastric cancer cell migration. These results suggest that Wnt-5a stimulates cell migration by regulating focal adhesion complexes and that Wnt-5a is not only a prognostic factor but also a good therapeutic target for gastric cancer.
Circulating tumor cells in pancreatic cancer patients: Methods of detection and clinical implications (2013)

The poor prognosis of pancreatic cancer patients is associated with the frequent and early dissemination of the disease, as well as late detection due to unspecific and late symptoms from the primary tumor. Pancreatic cancers frequently spread to the liver, lung and skeletal system, suggesting that pancreatic tumor cells must be able to intravasate and travel through the circulation to distant organs. Circulating tumor cells (CTCs) are tumor cells that have acquired the ability to enter the circulatory system; this cell population is ultimately responsible for the development of metastases in distant organs. Clinical studies have revealed that the presence of CTCs in blood is correlated with disease progression for other cancers, such as breast, colorectal and prostate cancer. However, as CTCs are extremely rare, both enrichment and sensitive methods of detection are required for their enumeration. This review highlights various enrichment procedures and methods for the detection of CTCs. Furthermore, we systematically review previously reported studies of the clinical relevance of CTC detection in pancreatic cancer patients. There is evidence that the presence of CTCs also correlates with an unfavorable outcome in pancreatic cancer patients. However, technical/methodological issues may explain why some studies only show a trend toward an association between CTC detection and disease progression. Larger studies, as well as characterization of the CTC population, are required to achieve further insight into the clinical implications of CTC detection in pancreatic cancer patients.
Association of an IRF5 gene functional polymorphism with Sjögren's syndrome (2007)

This study is the first to demonstrate a significant association between primary SS and the IRF5 rs2004640 T allele. These results, which require further replication on larger populations, suggest that besides their association with identical major histocompatibility complex gene polymorphisms, primary SS and SLE share IRF gene polymorphisms as a common genetic susceptibility factor.
Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAldose reductase: model for a new paradigm of enzymic perfection in detoxification catalystsCharles E. GrimshawCite this: Biochemistry 1992, 31, 42, 10139–10145Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://doi.org/10.1021/bi00157a001RIGHTS & PERMISSIONSArticle Views165Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (868 KB) Get e-Alerts Get e-Alerts
Vegetative Propagation of Pinus sylvestris (1975)

Abstract Methods for the vegetative propagation of Pinus sylvestris L. from interfascicular shoots are described. Using 5‐year‐old plants the outgrowth of interfascicular shoots was promoted by removal of terminal and lateral buds; this response was augmented substantially by application of cytokinin, tri‐iodobenzoic acid, alar and morphactin alone and especially in combination. The rooting capacity of shoot cuttings from interfascicular shoots appeared to be largely determined by the state of growth of the stock plant. Cuttings from dormant stock plants subjected to short‐day treatment followed by a period of low temperature gave the best rooting, especially when the cuttings themselves had been cold‐stored prior to planting. Rooting was optimal when such cuttings were treated with a mixture of 25 mg/l of indolebutyric acid and 25 mg/l of napthaleneacetic acid as a 48 h basal soak, and were planted on a heated mistbench under extended illumination; over 90% of such cuttings could be rooted. These results are discussed in relation to bud activity, endogenous hormone levels and promoting tissue extracts also tested.
Effect of mutagenesis at serine 653 of Arabidopsis thaliana acetohydroxyacid synthase on the sensitivity to imidazolinone and sulfonylurea herbicides (1999)

Resistance to sulfonylurea and imidazolinone herbicides can occur by mutations in acetohydroxyacid synthase (EC 4.1.3.18). Changing serine 653 to asparagine is known to cause insensitivity to imidazolinones but not to sulfonylureas. Here, S-653 of the Arabidopsis thaliana enzyme was mutated to alanine, threonine and phenylalanine. The purified mutated enzymes resemble wild-type in their enzymatic properties. The threonine and phenylalanine mutants are imidazolinone-resistant and the latter is also slightly sulfonylurea-resistant. The alanine mutant remains sensitive to both herbicides. The results suggest that the beta-hydroxyl group is not required for imidazolinone binding and that the size of the side-chain determines resistance.
Human Bocavirus and Acute Wheezing in Children (2007)

Human bocavirus is prevalent among children with acute wheezing and can cause systemic infection. Results suggest a model for bocavirus infection in which high viral loads are potentially associated with respiratory symptoms and low viral loads indicate asymptomatic shedding. Therefore, quantitative polymerase chain reaction analysis may be important for additional studies of human bocavirus.
Pim‐3 is expressed in endothelial cells and promotes vascular tube formation (2009)

Pim-3 is a member of proto-oncogene Pim family that encodes serine/threonine kinases. Pim proteins regulate both apoptosis and cellular metabolism by phosphorylating their substrates. Here, we report for the first time that Pim-3 is highly expressed at mRNA and protein levels in endothelial cells (ECs). We found that Pim-3 is concentrated at the cellular lamellipodia and co-localized with focal adhesion kinase (FAK). Pim-3 was dispersed from lamellipodia when ECs were treated with cytochalasin D, an inhibitor of actin polymerization. In addition, small-interfering RNA (siRNA)-mediated gene knockdown of Pim-3 significantly impaired EC spreading, migration, and proliferation, leading to a reduction in tube-like structure formation in a Matrigel assay. These results provide the novel evidence that Pim-3 plays an essential role in EC spreading and migration, suggesting that Pim-3 may be an important molecular target for the development of small-molecule inhibitors of angiogenesis.