gebhart/patrepeval huggingface dataset:
B interferometry for the calibration of RF transmitter arrays (2009)

Multiple-channel RF transmission holds great promise for MRI, especially for human applications at high fields. For calibration it requires mapping the effective RF magnetic fields, B(1) (+), of the transmitter array. This is challenging to do accurately and fast due to the large dynamic range of B(1) (+) and tight SAR constraints. In the present work, this problem is revisited and solved by a novel mapping approach relying on an interference principle. The B(1) (+) fields of individual transmitter elements are measured indirectly by observing their interference with a SAR-efficient baseline RF field. In this fashion even small RF fields can be observed in the B(1) (+) -sensitive large-flip-angle regime. Based on a set of such experiments B(1) (+) maps of the individual transmitter channels are obtained by solving a linear inverse problem. Confounding relaxation and off-resonance effects are addressed by an extended signal model and nonlinear fitting. Using the novel approach, 2D mapping of an 8-channel transmitter array was accomplished in less than a minute. For validation it is demonstrated that mapping results do not vary with T(1) or parameters of the mapping sequence. In RF shimming experiments it is shown that the measured B(1) (+) maps accurately reflect the linearity of RF superposition.
Performance driven multi-level and multiway partitioning with retiming (2000)

In this paper, we study the performance driven multiw ay circuit partitioning problem with consideration of the significant difference of local and global interconnect delay induced by the partitioning. We develop an efficient algorithm HPM (Hierarc hicalP erformance driven Multi-level partitioning) that simultaneously considers cutsize and delay minimization with retiming. HPM builds a multi-lev el cluster hierarc hy and performs various refinement while gradually decomposing the clusters for simultaneous cutsize and delay minimization. We provide comprehensive experimental justification for each step involv ed in HPM and in-depth analysis of cutsize and delay tradeoff existing in the performance driven partitioning problem. HPM obtains (i) 7% to 23% better delay compared to the state-of-the-art cutsize driven hMetis [11] at the expense of 19% increase in cutsize, and (ii) 81% better cutsize compared to the state-of-the-art delay driven PRIME [2] at the expense of 6% increase in delay.
Thinking big (and small) about energetic materials (2006)

A significant recent development in the field of energetic materials has been the introduction of nanotechnology. Nanoparticle based materials have the potential of releasing more than twice as much energy as the best molecular explosives. The possibility of developing nanoenergetic materials that are optimised for specific applications by controlling the spatial organisation on length scales ranging from nanometres to metres is discussed. To do so a fundamental understanding of the relationships between structure and performance that does not yet exist is required. Experimental measurements using molecular spectroscopy with high time and space resolution are presented that help clarify the fundamental mechanisms of reaction between fuel nanoparticles and surrounding oxidisers, and the relationships between nanoenergetic structure and performance properties such as the energy release rate and the reaction propagation rate.
Fluid mechanics analysis of a spring-loaded jet injector (1999)

A syringe jet injector is a device designed to administer a drug quickly and painlessly through the skin. Though syringe jet injectors have been in use for almost 50 years, current designs still suffer from inconsistent performance. To better understand the fluid mechanics of jet injection and gain insight into how the design might influence performance, two theoretical analyses to determine the fluid pressure profile at the exit orifice were conducted. The first was a continuum analysis assuming static incompressibility. Results demonstrated that the maximum jet pressure was highly sensitive to the spring constant, initial piston velocity, and piston cross-sectional area while the time to achieve the maximum pressure was most sensitive to the injection chamber length, initial piston velocity, bulk modulus of the injectant, and the piston cross-sectional area. The second analysis was a shock wave analysis. Results demonstrated a stepwise pressure-time plot that was similar in magnitude to that for the continuum analysis assuming static incompressibility. Results from these two investigations are useful for design modification of the jet injector to achieve desired pressure-time profiles at the orifice. Control of pressure-time profiles may help to achieve a more consistent and effective injection process.
APPENDIX II Complete Annotated Lambda Sequence (1983)

Here we present the completely annotated λ DNA sequence. The l strand of the λ “wild-type” DNA1 is presented above the ruler line in the 5′–3′ direction, and the r strand, below the ruler in the 3′–5′ direction. Translation in all six frames is presented below the DNA sequence in the single-letter amino acid code. Those translation frames believed to actually code for proteins are capitalized. The single-letter amino acid code is as follows: A = AlaG = GlyM = MetS = SerC = CysH = HisN = AsnT = ThrD = AspI = IleP = ProV = ValE = GluK = LysQ = GlnW = TrpF = PheL = LeuR = ArgY = Tyr All restriction cut sites predicted from their recognition sequences on the l strand are indicated above the base to the left of the internucleotide site of cutting. All mapped sites presented in Appendix I are presented here as annotations to the sequence. The four-character designation is indicated above the numbered base, and the complete annotation is repeated below the line of sequence. For annotation numbering conventions, see Appendix I. Following the sequence are two explanatory tables. Table 1 lists the restriction enzyme recognition sequences for which the sequence was searched. Table 2 summarizes all restriction sites predicted by the λ DNA sequence. 1 For a summary of all of the experimentally mapped restriction sites and...
A Taql polymorphism in the human interleukin‐1β (IL‐1β) gene correlates with IL‐1β secretion in vitro (1992)

In the present study we searched for restriction fragment length polymorphisms (RFLP) in the human interleukin-1 beta (IL-1 beta) gene and for correlations to monocyte (Mo) function in non-related healthy donors and insulin-dependent diabetic patients. We demonstrated a diallelic polymorphism with the restriction enzyme TaqI consisting of fragments of 9.4 kb and 13.4 kb. No differences in allele or genotype frequencies of this RFLP were observed between randomly selected controls and randomly selected patients with insulin-dependent diabetes mellitus (IDDM). However, when analysing IDDM patients negative for HLA-DR3 and -DR4, our data demonstrate that the 13.4 kb allele is more frequent in this group compared to a matched control group. The functional impact of this RFLP was studied by analysing in vitro stimulated Mo IL-1 beta response. An IL-1 beta allele dosage effect on secretory capacity was observed after LPS-stimulation: 13.4/13.4 kb homozygous individuals secreted significantly more IL-1 beta than 9.4/13.4 kb heterozygous individuals, who secreted significantly more than 9.4/9.4 kb homozygous individuals. Analyses of supernatants from LPS-stimulated Mo cultures from individuals with each TaqI IL-1 beta genotype revealed no differences in the mouse thymocyte co-stimulatory assay when compared on a molar basis, indicating that the TaqI polymorphism gave rise only to quantitative differences in expression levels and probably not to a mutant IL-1 beta.(ABSTRACT TRUNCATED AT 250 WORDS)
Non-Targeted and Targeted Protein Movement through Plasmodesmata in Leaves in Different Developmental and Physiological States (2001)

Plant cells rely on plasmodesmata for intercellular transport of small signaling molecules as well as larger informational macromolecules such as proteins. A green fluorescent protein (GFP) reporter and low-pressure microprojectile bombardment were used to quantify the degree of symplastic continuity between cells of the leaf at different developmental stages and under different growth conditions. Plasmodesmata were observed to be closed to the transport of GFP or dilated to allow the traffic of GFP. In sink leaves, between 34% and 67% of the cells transport GFP (27 kD), and between 30% and 46% of the cells transport double GFP (54 kD). In leaves in transition transport was reduced; between 21% and 46% and between 2% and 9% of cells transport single and double GFP, respectively. Thus, leaf age dramatically affects the ability of cells to exchange proteins nonselectively. Further, the number of cells allowing GFP or double GFP movement was sensitive to growth conditions because greenhouse-grown plants exhibited higher diffusion rates than culture-grown plants. These studies reveal that leaf cell plasmodesmata are dynamic and do not have a set size exclusion limit. We also examined targeted movement of the movement protein of tobacco mosaic virus fused to GFP, P30::GFP. This 58-kD fusion protein localizes to plasmodesmata, consistently transits from up to 78% of transfected cells, and was not sensitive to developmental age or growth conditions. The relative number of cells containing dilated plasmodesmata varies between different species of tobacco, with Nicotiana clevelandii exhibiting greater diffusion of proteins than Nicotiana tabacum.
Photoinduced charge transfer between fullerenes (C60 and C70) and semiconductor zinc oxide colloids (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoinduced charge transfer between fullerenes (C60 and C70) and semiconductor zinc oxide colloidsPrashant V. KamatCite this: J. Am. Chem. Soc. 1991, 113, 25, 9705–9707Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00025a064https://doi.org/10.1021/ja00025a064research-articleACS PublicationsRequest reuse permissionsArticle Views522Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. (1993)

Spindle-shaped cells of vascular origin are the probable tumor cells of Kaposi sarcoma (KS). These cells, derived from patients with KS and AIDS, proliferate in response to extracellular Tat protein of human immunodeficiency virus type 1. Normal vascular cells, believed to be the progenitors of AIDS-KS cells, acquire spindle morphology and become responsive to the mitogenic effect of Tat after culture with inflammatory cytokines. Such cytokines are increased in human immunodeficiency virus type 1-infected people, suggesting that immune stimulation (rather than immune deficiency) is a component of AIDS-KS pathogenesis. Here we show that (i) Tat promotes adhesion of AIDS-KS and normal vascular cells; (ii) adhesion of normal vascular cells to Tat is induced by exposure of the cells to the same cytokines; (iii) adhesion is associated with the amino acid sequence RGD of Tat through a specific interaction with the integrin receptors alpha 5 beta 1 and alpha v beta 3, although it is augmented by the basic region; and (iv) the expression of both integrins is increased by the same cytokines that promote these cells to acquire spindle morphology and become responsive to the adhesion and growth effects of Tat. The results also suggest that RGD-recognizing integrins mediate the vascular cell-growth-promoting effect of Tat.
The effect of Psilocybe cubensis extract on hippocampal neurons in vitro. (2001)

The action of P. cubensis mushroom extract, containing psilocybin (PCB) and psilocin, on spike activity of hippocampal CA1 pyramidal neurons was studied in in vitro rat brain slices. In 38 (76%) out of 50 investigated neurons spike activity was decreased, in 2 (4%) cells it increased. There was no response 10 (20%) neurons. Application of the extract caused short burst firing in 12 (24%) neurons. All neurons showing inhibition during PCB-containing extract application, were also inhibited by serotonin (5-HT). Usually inhibitory reaction did not last over 4-5 min upon 3 min extract application and could be prolonged up to 10-43 min up on serotonin application. Part of neurons were inhibited by serotonin and did not react to extract application. Inhibitory reactions induced by extract application were blocked by ritanserin in half of the tested units and were induced due to activation of 5-HT2 serotonin receptors. The extract suppressed excitative spike reactions caused by application of L-glutamic acid. It is concluded, that application of PCB-containing extract in most cases reduced spike activity in hippocampal CA1 pyramidal neurons and suppressed glutamate transmission.
A Proposal for Standardization of Home Bus System for Home Automation (1983)

In order to combine home electronic and electrical equipment effectively and realize Home Automation (HA), it is essential to establish a standard for information distribution newtowks and interfaces which can be used for those equipment. In this paper we propose a plan for standardization of the Home Bus System (HBS). This plan has been created after a number of experiments for various applications have been conducted toward HA for two years.
Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice (2005)

Activation of vascular endothelium plays an essential role in vasoocclusion in sickle cell disease. The anti-inflammatory agents dexamethasone and adhesion molecule-blocking antibodies were used to inhibit endothelial cell activation and hypoxia-induced vasoocclusion. Transgenic sickle mice, expressing human alpha-, beta(S)-, and beta(S-Antilles)-globins, had an activated vascular endothelium in their liver, lungs, and skin, as exhibited by increased activation of NF-kappaB compared with normal mice. NF-kappaB activation increased further in the liver and skin after sickle mice were exposed to hypoxia. Sickle mice had decreases in red blood cell (RBC) velocities and developed vasoocclusions in subcutaneous venules in response to hypoxia. Dexamethasone pretreatment prevented decreases in RBC velocities and inhibited vasoocclusions and leukocyte-endothelium interactions in venules after hypoxia. Dexamethasone treatment inhibited NF-kappaB, VCAM-1, and ICAM-1 expression in the liver, lungs, and skin of sickle mice after hypoxia-reoxygenation. VCAM-1 or ICAM-1 blockade with monoclonal antibodies mimicked dexamethasone by inhibiting vasoocclusion and leukocyte adhesion in sickle mice, demonstrating that endothelial cell activation and VCAM-1 and ICAM-1 expression are necessary for hypoxia-induced vasoocclusion in sickle mice. VCAM-1, ICAM-1, and vasoocclusion increased significantly 3 days after dexamethasone discontinuation, possibly explaining rebounds in vasoocclusive crises observed after withdrawal of glucocorticosteroids in sickle patients. We conclude that anti-inflammatory treatments that inhibit endothelial cell activation and adhesion molecule expression can inhibit vasoocclusion in sickle cell disease. Rebounds in vasoocclusive crises after dexamethasone withdrawal are caused by rebounds in endothelial cell activation.
Programmable vision processor/controller for flexible implementation of current and future image compression standards (1992)

The vision processor (VP) and vision controller (VC), two integrated products dedicated to video compression, are discussed. The chips implement the P*64, JPEG, and MPEG image compression standards. The VP forms the heart of the image compression system. It performs discrete cosine transform (DCT), quantization, and motion estimation, as well as inverse DCT, and inverse quantization. The highly parallel and microcode-based processor performs all of the JPEG, MPEG, and P*64 algorithms. The VC smart microcontroller controls the compression process and provides the interface to the host system. It captures pixels from a video source, performs video preprocessing, supervises pixel compression by the VP, performs Huffman encoding, and passes the compressed data to the host over a buffered interface. It takes compressed data from the host, performs coder decoding, supervises decompression via the VP, performs postprocessing, and generates digital pixel output for a video destination such as a monitor.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modulation of Spinal Pain Mechanisms by Spinal Cord Stimulation and the Potential Role of Adjuvant Pharmacotherapy (1997)

Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms. Concomitant intrathecal administration of receptor-active drugs modulating the function of the GABA and adenosine systems may both depress and enhance the effects of SCS. The first few patients with simultaneous intrathecal administration of the GABAB agonist baclofen and/or adenosine together with SCS, when the stimulation alone proved insufficient, are reported.
Structure Optimization for Deep Multimodal Fusion Networks using Graph-Induced Kernels (2017)

A popular testbed for deep learning has been multimodal recognition of human activity or gesture involving diverse inputs such as video, audio, skeletal pose and depth images. Deep learning architectures have excelled on such problems due to their ability to combine modality representations at different levels of nonlinear feature extraction. However, designing an optimal architecture in which to fuse such learned representations has largely been a non-trivial human engineering effort. We treat fusion structure optimization as a hyper-parameter search and cast it as a discrete optimization problem under the Bayesian optimization framework. We propose a novel graph-induced kernel to compute structural similarities in the search space of tree-structured multimodal architectures and demonstrate its effectiveness using two challenging multimodal human activity recognition datasets.
High performance continuous wave 1.3 μm quantum dot lasers on silicon (2014)

We demonstrate record performance 1.3 μm InAs quantum dot lasers grown on silicon by molecular beam epitaxy. Ridge waveguide lasers fabricated from the as-grown material achieve room temperature continuous wave thresholds as low as 16 mA, output powers exceeding 176 mW, and lasing up to 119 °C. P-modulation doping of the active region improves T0 to the range of 100–200 K while maintaining low thresholds and high output powers. Device yield is presented showing repeatable performance across different dies and wafers.
Molecular Contrast Optical Coherence Tomography: A Review¶ (2005)

This article reviews the current state of research on the use of molecular contrast agents in optical coherence tomography (OCT) imaging techniques. After a brief discussion of the basic principle of OCT and the importance of incorporating molecular contrast agent usage into this imaging modality, we shall present an overview of the different molecular contrast OCT (MCOCT) methods that have been developed thus far. We will then discuss several important practical issues that define the possible range of contrast agent choice, the design criteria for engineered molecular contrast agent and the implementability of a given MCOCT method for clinical or biological applications. We will conclude by outlining a few areas of pursuit that deserve a greater degree of research and development.
A homogeneous nucleic acid hybridization assay based on stand displacement (1987)

A homogeneous nucleic acid hybridization assay which is conducted in solution and requires no separation steps is described. The assay is based on the concept of strand displacement. In the strand displacement assay, an RNA "signal strand" is hybridized within a larger DNA strand termed the "probe strand", which is, in turn, complementary to the target nucleic acid of interest. Hybridization of the target nucleic acid with the probe strand ultimately results in displacement of the RNA signal strand. Strand displacement, therefore, causes conversion of the RNA from double to single-stranded form. The single-strand specificity of polynucleotide phosphorylase (EC 2.7.7.8) allows discrimination between double-helical and single-stranded forms of the RNA signal strand. As displacement proceeds, free RNA signal strands are preferentially phosphorolyzed to component nucleoside diphosphates, including adenosine diphosphate. The latter nucleotide is converted to ATP by pyruvate kinase(EC 2.7.1.40). Luciferase catalyzed bioluminescence is employed to measure the ATP generated as a result of strand displacement.
Isolation of an IgH gene circular DNA clone from human bone marrow (1989)

Circular DNA was obtained from human bone marrow. Then a phage library was prepared and screened by use of two probes of the IgH gene; 5'-DHQ52, containing the 5' flanking region of DHQ52, and JH4.3, containing the sequence from JH3 to the 3' flanking region of JH6. One clone, HBMC-1, that was DHQ52+JH4.3- was obtained. HBMC-1 had the germline IgH region upstream of JH1 and the 3' flanking region of DXP1. A recombination signal sequence flanking the 5' side of the JH1 segment was attached to the recombination signal sequence flanking the 3' side of DXP1 forming a head-to-head structure of two 7mers with 10 nucleotides in-between. HBMC-1 is thus considered to be a circular DNA deleted as a consequence of DXP1-JH1 joining of the IgH gene.
c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation (1998)

The MafB transcriptional activator plays a pivotal role in regulating lineage-specific gene expression during hematopoiesis by repressing Ets-1-mediated transcription of key erythroid-specific genes in myeloid cells. To determine the effects of Maf family proteins on the transactivation of myeloid-specific genes in myeloid cells, we tested the ability of c-Maf to influence Ets-1- and c-Myb-dependent CD13/APN transcription. Expression of c-Maf in human immature myeloblastic cells inhibited CD13/APN-driven reporter gene activity (85 to 95% reduction) and required the binding of both c-Myb and Ets, but not Maf, to the promoter fragment. c-Maf's inhibition of CD13/APN expression correlates with its ability to physically associate with c-Myb. While c-Maf mRNA and protein levels remain constant during myeloid differentiation, formation of inhibitory Myb-Maf complexes was developmentally regulated, with their levels being highest in immature myeloid cell lines and markedly decreased in cell lines representing later developmental stages. This pattern matched that of CD13/APN reporter gene expression, indicating that Maf modulation of c-Myb activity may be an important mechanism for the control of gene transcription during hematopoietic cell development.