Original Articles: Prostate Cancer: Pathological Features of Hereditary Prostate Cancer (1995)

No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1995Original Articles: Prostate Cancer: Pathological Features of Hereditary Prostate Cancer Sheldon I. Bastacky, Kirk J. Wojno, Patrick C. Walsh, Marne J. Carmichael, and Jonathan I. Epstein Sheldon I. BastackySheldon I. Bastacky , Kirk J. WojnoKirk J. Wojno , Patrick C. WalshPatrick C. Walsh , Marne J. CarmichaelMarne J. Carmichael , and Jonathan I. EpsteinJonathan I. Epstein View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)67619-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The aim of this study was to characterize the pathological features of hereditary prostate cancer, a recently recognized variant of prostate cancer with an autosomal dominant inheritance of a rare highly penetrant gene associated with early onset of disease. We compared the histology at radical prostatectomy of clinical stage T2 prostate cancer, including its relationship to prostatic intraepithelial neoplasia, in men with a family history of prostate cancer to those without a family history of prostate cancer. Three cohorts (hereditary, familial and sporadic) were identified based on pedigree analysis. A hereditary subgroup (28 patients) met 1 of the following 3 criteria: 1) cluster of greater than 3 affected relatives within the nuclear family, 2) occurrence of prostate cancer in each of 3 generations in either the proband paternal or maternal lineage, or 3) a cluster of 2 relatives affected at an early age of less than 55 years. This subgroup was compared to an age-matched subgroup with family history of prostate cancer (26 patients) yet the aforementioned conditions for inclusion within the hereditary subgroup were not met and to a sporadic subgroup without a family history of prostate cancer (27 patients). All parameters were statistically similar among the groups except that hereditary and familial group multifocal tumors were of lower grade (p = 0.0001), sporadic cases had a greater proportion of small multifocal cancers associated with prostatic intraepithelial neoplasia (p = 0.02) and the familial group had a weaker correlation between total tumor volume and grade. References 1 : An investigation of the familial aspects of carcinoma of the prostate. Cancer1960; 13: 739. Google Scholar 2 : Genetic epidemiology of prostate cancer in the Utah Mormon genealogy. Cancer Surv.1982; 1: 47. Google Scholar 3 : Familial factors affecting prostatic cancer risk and plasma sex-steroid levels. Prostate1985; 6: 121. Google Scholar 4 : A computerized family history database system. Sociol. Soc. Res.1979; 63: 506. Google Scholar 5 : Family history and the risk of prostate cancer. Prostate1990; 17: 337. Google Scholar 6 : Familial patterns of prostate cancer: a case-control analysis. J. 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Google Scholar From the Departments of Pathology and Urology, The Johns Hopkins University School of Medicine and the James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byYoon G, Wang W, Osunkoya A, Lane Z, Partin A and Epstein J (2018) Residual Tumor Potentially Left Behind After Local Ablation Therapy in Prostate AdenocarcinomaJournal of Urology, VOL. 179, NO. 6, (2203-2206), Online publication date: 1-Jun-2008.Serfling R, Shulman M, Thompson G, Xiao Z, Benaim E, Roehrborn C and Rittmaster R (2018) Quantifying the Impact of Prostate Volumes, Number of Biopsy Cores and 5α-Reductase Inhibitor Therapy on the Probability of Prostate Cancer Detection Using Mathematical ModelingJournal of Urology, VOL. 177, NO. 6, (2352-2356), Online publication date: 1-Jun-2007. 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Volume 153Issue 3SMarch 1995Page: 987-992 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Sheldon I. Bastacky More articles by this author Kirk J. Wojno More articles by this author Patrick C. Walsh More articles by this author Marne J. Carmichael More articles by this author Jonathan I. Epstein More articles by this author Expand All Advertisement PDF downloadLoading ...