gebhart/patrepeval huggingface dataset:
Formation and structure of the tris(catecholato)vanadate(IV) complex in aqueous solution (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation and structure of the tris(catecholato)vanadate(IV) complex in aqueous solutionMario Branca, Giovanni Micera, Alessandro Dessi, Daniele Sanna, and Kenneth N. RaymondCite this: Inorg. Chem. 1990, 29, 8, 1586–1589Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ic00333a030https://doi.org/10.1021/ic00333a030research-articleACS PublicationsRequest reuse permissionsArticle Views316Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
SEJITS: Getting Productivity and Performance With Selective Embedded JIT Specialization (2010)

Today's "high productivity" programming languages such as Python lack the performance of harder-to-program "efficiency" languages (CUDA, Cilk, C with OpenMP) that can exploit extensive programmer knowledge of parallel hardware architectures. We combine efficiency-language performance with productivity-language programmability using selective embedded just-in-time specialization (SEJITS). At runtime, we specialize (generate, compile, and execute efficiency-language source code for) an application-specific and platform-specific subset of a productivity language, largely invisibly to the application programmer. Because the specialization machinery is implemented in the productivity language itself, it is easy for efficiency programmers to incrementally add specializers for new domain abstractions, new hardware, or both. SEJITS has the potential to bridge productivity-layer research and efficiency-layer research, allowing domain experts to exploit different parallel hardware architectures with a fraction of the programmer time and effort usually required.
Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site (1996)

Retroviral vectors contain viral cis-acting elements to achieve the packaging, reverse transcription, integration, and expression of the retroviral genomic nucleic acid sequence. However, these elements are not useful in the integrated provirus and can be the cause of problems. We have developed a vector which eliminates the majority of these viral elements. This vector, a long terminal repeat (LTR) enhancer-deleted vectors, exploits the Cre-lox recombination system of the P1 bacteriophage. The Cre-lox system is neutral for eukaryotic cells. The 32-nucleotide loxP site is inserted within the U3 of the 3' LTR along with with the gene to be transduced (in place of the viral enhancers). Following the LTR-mediated loxP duplication, the LTRs can be recombined by the Cre enzyme. The structure of the resulting provirus in the host genome corresponds to a single LTR (deleted of the viral enhancers) carrying a single copy of the gene to be transduced. If the Cre expression unit is furnished after the integration of a loxP-containing virus, the efficiency of the recombination is not absolute. If the Cre expression unit is inserted between the two LTRs, only single LTR proviral structures are found following infection by the retroviral vector.
Inhibitory Effect of LHRH and Its Agonists on Testicular Gonadotrophin Receptors and Spermatogenesis in the Rat (1978)

Treatment of adult male rats with the potent LHRH agonists [D‐Leu 6 , des‐Gly‐NH 2 10 ]LHRH ethylamide or [D‐Ala 6 . des‐Gly‐NH 2 10 ]LHRH ethylamide led to a marked reduction of testicular LH and prolactin receptor levels accompanied by decreased plasma testosterone levels and testis, seminal vesicle and prostate weight. Maximal inhibitory effects were seen at a dose of 50 ng. After a single injection, maximal inhibitory effects were seen at 2–4 days with return toward normal levels at later time intervals. Similar results were obtained with LHRH itself although 5 μg was required for maximal effects. When the LHRH analog was administered twice a week at the 100 ng dose, degenerative signs appeared in the seminiferous tubules after one week while at four weeks, degenerative changes were so advanced that almost all germ cells had disappeared leaving only Sertoli cells.
Metabolism of azathioprine to 6‐thioguanine nucleotides in patients with pemphigus vulgaris. (1987)

Azathioprine metabolism, to red cell 6-thioguanine nucleotides (6TGN), was studied in four patients with pemphigus vulgaris. Throughout treatment blood samples were taken for red cell 6TGN assay and differential white cell counts. Metabolite steady-state occurred in three patients in 2, 2 and 4 months respectively. In the fourth patient red cell 6TGN concentrations increased slowly over 3 years. There was a significant negative correlation between 6TGN concentrations and the white blood cell count (rs = -0.92, P less than 0.0005) in this patient.
A bipolar-DC-bus EV fast charging station with intrinsic DC-bus voltages equalization and minimized voltage ripples (2015)

This paper proposes a bipolar-dc-bus Electric Vehicle (EV) charging station without a line-frequency transformer at the medium-voltage grid side. It is mainly composed of the Neutral Point Clamped (NPC) converter based central ac-dc station and the parallel isolated three-level dc-dc converter based fast chargers. Due to the elimination of the line-frequency transformer, the volume and cost of the system are reduced. Meanwhile, the isolation and step-down between high dc-bus voltages and low load voltages are performed through the high-frequency transformers, leading to increased voltage utilization of switching devices. In order to guarantee the bipolar dc buses balance and minimize the dc-bus voltage ripples, the 180°-interleaved operation for the two parallel isolated three-level dc-dc converters is proposed to make the total neutral-point current zero so that all fast chargers do not bring any unbalance problems. The proposed 180°-interleaved operating principle has been analyzed in detail, then simulation results are presented to verify its performance.
The effects of mutations in the ant promoter of phage P22 depend on context. (1988)

Recombination was used to construct 22 two- or three-way combinations of down- and up-mutations in Pant, a strong, near-consensus promoter of phage P22. The relative strengths of these promoters in vivo were assayed by fusing them to an ant/lacZ gene fusion and measuring beta-galactosidase levels produced by lysogens carrying the fusions on single-copy prophages. The results of these assays show that the magnitude of the effect of a promoter mutation can vary considerably when its context is changed by the presence of another mutation. In addition, as Pant approaches conformity with the consensus promoter sequence, the up-mutations decrease promoter strength, even though the same mutations increase promoter strength in the presence of a down-mutation. These context effects imply that individual consensus base pairs cannot be considered to contribute to promoter strength independently.
Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma (2004)

The role of humoral immunity in hepatitis C virus (HCV) infections is uncertain. Nevertheless, there is increasing evidence for neutralizing antibodies to HCV in the serum or plasma of chronically infected individuals. Immune globulins prepared by ethanol fractionation of plasma had long been considered safe until a commercial immune globulin product, Gammagard, prepared from plasma from which units containing anti-HCV had been excluded, transmitted HCV to recipients. Studies suggested that the exclusion might have removed neutralizing antibodies from the plasma and hence compromised the safety of the resulting immune globulins. In the present study, by using chimpanzees and a recently validated in vitro system based on neutralization of infectious HCV pseudoparticles, we found broadly reactive neutralizing and protective antibodies in experimental immune globulin preparations made from anti-HCV-positive donations. Neutralizing antibodies were also found in Gammagard lots made from unscreened plasma that did not transmit hepatitis C but not in Gammagard lots, which were prepared from anti-HCV-screened plasma, that did transmit hepatitis C. The results provide an explanation for the mechanism by which the safety of this product was compromised. Immune globulins made from anti-HCV-positive plasma and containing broadly reactive neutralizing antibodies may provide a method of preventing HCV infection.
Experimental Evaluation of Shaped Inputs to Reduce Vibration for a Cartesian Robot (1990)

Since all robots have some inherent flexibility, fast motions tend to excite system vibrations. This paper develops shaped inputs that generate fast motions with minimum residual vibration. Shaped force inputs are constructed from a versine series, with coefficients of the harmonic terms chosen to maximize kinetic energy and minimize excitation energy at the system natural frequencies. These force inputs are doubly integrated to obtain position waveforms that serve as reference profiles for a closed-loop controller. A Cartesian robot is used as an experimental system to test these shaped reference inputs and to compare their responses to simple step responses. Results indicate considerable reduction in residual vibration with the shaped inputs. This is especially useful when modal coupling exists, since vibration in other axes can be prevented by driving the moving axis with shaped inputs having no excitation energy at the coupled mode frequencies.
Multitone spread spectrum multiple access communications system in a multipath Rician fading channel (1995)

The paper proposes a new multiple access communications system based on the combination of multitone transmission and direct sequence spectrum spreading (DS/SS). Multitone transmission is proposed because the associated larger symbol duration is favorable to combat the effects of multipath propagation. The multiple access capability of the system is achieved by means of DS/SS which also helps to combat the presence of several paths. On the other hand, DS/SS is also attractive to decrease the multiple access interference. The performance of this system is investigated for a multipath, slowly Rician fading and frequency selective channel, and a suboptimal receiver based on matched filters. The multiple access interference is also taken into account, A model for the computation of the bit error probability is derived for QPSK modulation of the orthogonal tones by the spread symbols. The system performance is investigated for selection diversity and maximal ratio combining (RAKE reception). Then the influence of the number of tones is investigated for given bandwidth, bit rate and transmission power. The positive effect of a multitone spread spectrum transmission is demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The ABA-1 Allergen of the Parasitic Nematode Ascaris suum: Fatty Acid and Retinoid Binding Function and Structural Characterization (1995)

We report here on the structure and function of the ABA-1 allergen protein of the parasitic nematode Ascaris, the first nematode allergen to be characterized in detail. Using the fluorescent fatty acid analog 11-(((5-(dimethylamino)-1-naphthalenyl)sulfonyl)amino)undecanoic acid (DAUDA), it was demonstrated that ABA-1 is a fatty acid binding protein (FABP) with a high affinity for the fluorescent analog (8.8 x 10(-8) M) and for oleic acid in competition experiments (1.3 x 10(-8) M), with a single binding site for ligand per monomer unit. Blue-shifting of fluorescence emission of DAUDA upon binding was unprecedented in degree among FABPs, being equivalent to that occurring in cyclohexane. A similarly blue-shifted spectrum was obtained with a probe in which the fluorophore was bound to the alpha carbon of a fatty acid, indicating that the carboxylate group of bound fatty acids is probably not exposed to solvent. In competition experiments and by observation of changes in their intrinsic fluorescence, retinol and retinoic acid were also found to bind in the fatty acid binding site. Circular dichroism (CD) of the ABA-1 protein revealed a high alpha-helix content (59%) which was consistent with the four-helix structure for the protein predicted from sequence algorithms. Fluorescence measurements showed that the single, highly conserved tryptophan residue is deeply buried in an unusually apolar environment and that this was unaffected by ligand binding. DSC studies of thermal stability indicate that unfolding of the ABA-1 dimer is cooperative and biphasic (Tm approximately 71 and 89 degrees C), suggesting a two-domain thermal unfolding process, again consistent with the predicted structure. Only the folding of the high-temperature domain is reversible on cooling. DSC confirmed the gel filtration analysis, which indicated that ABA-1 forms a dimer. Aside from being the first nematode allergen for which structure or function has been elucidated, ABA-1 provides a highly manipulable model for investigation of the interaction between hydrophobic ligands and alpha-helical proteins.
The Nucleocapsid of Hepatitis B Virus Is Both a T-Cell-Independent and a T-Cell-Dependent Antigen (1986)

One characteristic of the immune response during hepatitis B virus (HBV) infection in humans is the vigorous production and subsequent persistence of antibodies of immunoglobulin (Ig) classes M and G to the nucleocapsid antigen (HBcAg). In this study HBcAg was shown to be similarly immunogenic in mice. When injected into athymic (nude) B10.BR and athymic BALB/c mice, HBcAg induced IgM and IgG class antibodies to HBc in spite of the absence of T cells in nude mice. In euthymic mice, HBcAg efficiently stimulated T-cell proliferation in vitro and helper T-cell function in vivo. The dual functions of HBcAg as a T-cell-independent and a T-cell-dependent antigen may explain its enhanced immunogenicity. Denaturation of HBcAg yields a nonparticulate antigen designated HBeAg; when HBeAg was used as the immunogen, antibody production required helper T-cell function. Although HBcAg and HBeAg are serologically distinct, they are structurally related, and in these experiments were highly cross-reactive at the T-cell level. These results suggest that the elevated levels of IgM antibodies to HBc and the enhanced immunogenicity of HBcAg during HBV infection in humans reflect the ability of HBcAg to directly activate B cells to produce antibodies to HBc in the presence or absence of HBcAg- or HBeAg-sensitized T cells.
Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis (2015)

clinicaltrials.gov Identifier: NCT00508547.
Chemistry and biology of natural and designed enediynes. (1993)

Ever since the initial reports of the enediyne anticancer antibiotics in the late 1980s, researchers from a number of disciplines have been devoting increasing attention to their chemistry, biology, and potential medical applications. Synthetic chemists and molecular designers have been engaged in attempts to synthesize these molecules and to model their unique architecture. Considerable efforts have been directed at understanding and mimicking the various processes involved in the targeting, activation, and DNA cleavage associated with these natural products. This review summarizes the main contributions to the field, with particular emphasis on work from our laboratories. Highlights include studies of the Bergman reaction, which is central to the mechanism of action of enediynes, the design and chemical synthesis of a number of these systems, and biological studies with selected molecules. Finally, the total synthesis of calicheamicin gamma 1I, the most prominent member of this class of naturally occurring compounds, is discussed.
Transition flight control using adaptive neutral network dynamic inversion for Canard Rotor/Wing UAV (2014)

The problem of designing transition flight controller via improved adaptive neural network dynamic inversion for Canard Rotor/Wing (CRW) UAV is studied. The transition control strategy from rotary-wing mode to fixed-wing mode is derived according to the flight characteristic analysis. The controller is composed of trajectory outer-loop and attitude inner-loop. The dynamic inversion method is used to design these loops. In addition, the angular rate error equations with proportional-integral desired dynamics are used to design the adaptive update law for compensating the system model error. The main advantage of this approach is its ability of the fast adaptation that leads to good steady and transient performance as well as simple design process. The longitudinal nonlinear dynamic simulations show that this approach improves the stability and transient response of attitude angle and achieves the transition flight control of the CRW UAV successfully.
Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y (1997)

1. The thiazolidinedione BRL 49653 (rosiglitazone) induces hyperphagia and weight gain in obese, insulin-resistant fatty Zucker rats but not in lean insulin-sensitive rats. We investigated whether these responses might involve neuropeptide Y (NPY), leptin and insulin. 2. BRL 49653 (1 mg kg(-1) day(-1), orally) was given for 7 or 20 days to fatty and lean Zucker and Wistar rats. 3. In lean rats of either strain, BRL 49653 had no effect on food intake, body weight, plasma insulin and corticosterone, NPY or NPY mRNA levels. 4. Fatty rats given BRL 49653 showed a 30% increase in food intake and accelerated body weight gain (both P<0.01) after 7 and 20 days, but without significant changes in regional hypothalamic NPY or NPY mRNA levels. 5. Plasma leptin levels were twice as high in untreated fatty Zucker rats as in lean rats (P<0.01), but were unaffected by BRL 49653 given for 20 days. However, BRL 49653 reduced insulin levels by 42% and increased corticosterone levels by 124% in fatty rats (both P<0.01). 6. Hyperphagia induced in fatty Zucker rats by BRL 49653 does not appear to be mediated by either a fall in circulating leptin levels or increased activity of hypothalamic NPYergic neurones. The fall in plasma insulin and/or rise in corticosterone levels during BRL 49653 treatment may be involved, consistent with the postulated role of these hormones in the control of food intake.
Curcumin impairs tumor suppressor p53 function in colon cancer cells (2004)

Curcumin (diferuloylmethane) is being considered as a potential chemopreventive agent in humans. In vitro it inhibits transcription by NF-kappaB, and the activity of lipoxygenase or cyclooxygenase enzymes, which facilitate tumor progression. In vivo it is protective in rodent models of chemical carcinogenesis. Curcumin contains an alpha,beta-unsaturated ketone, a reactive chemical substituent that is responsible for its repression of NF-kappaB. In compounds other than curcumin this same electrophilic moiety is associated with inactivation of the tumor suppressor, p53. Here we report that curcumin behaves analogously to these compounds. It disrupts the conformation of the p53 protein required for its serine phosphorylation, its binding to DNA, its transactivation of p53-responsive genes and p53-mediated cell cycle arrest.
Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc. (2010)

Myc is an oncogenic transcription factor that promotes tumorigenesis. Recently, a dominant negative form of Myc (Omomyc) was shown to cause regression of lung tumors in a mouse model of lung cancer caused by KRAS mutation, suggesting that Myc might be a potential therapeutic target to treat the KRAS lung cancer. However, it is not yet known whether Omomyc can also inhibit the growth of human lung tumors that carry a similar KRAS mutation. In the present study, we demonstrate that Omomyc induces cell death of KRAS-mutated human lung adenocarcinoma A549 cells in vitro and in vivo. However, Omomyc does not induce cell death in human lung adenocarcinoma H441 cells that also carry the KRAS mutation. Interestingly, A549 cells express high levels of Myc, while H441 cells do not. Co-expression of exogenous Myc with Omomyc in H441 cells induces cell death, indicating that Omomyc requires high levels of Myc to induce cell death in KRAS mutation-positive lung adenocarcinoma. Here, we show for the first time that KRAS mutation-positive lung cancer displaying high levels of Myc could be treated by inhibiting Myc transactivation function.
Potential antitumor agents. 63. Structure-activity relationships for side-chain analogs of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid (1991)

A series of 16 analogues of the solid tumor active compound 9-oxo-9H-xanthene-4-acetic acid (XAA), with variations in the acetic acid side chain, have been prepared and evaluated for their ability to cause early haemorrhagic necrosis of colon 38 tumors in mice. The results extend the previous SAR for this class and confirm the necessity for a carboxylic acid group in a fixed disposition with respect to the xanthenone chromophore. None of the compounds showed superior potency to XAA itself, with virtually all alterations in the nature of the anionic center or its geometry with respect to the chromophore greatly reducing or abolishing activity. However, alpha-methylation of the side chain was permissible, and the two enantiomers of 5-methyl-alpha-methyl-XAA were separated and tested. Both were active, but the S-(+) enantiomer was much more dose-potent than the R-(-) enantiomer, in both the in vivo tumor necrosis assay and an in vitro assay measuring the stimulation of nitric oxide production by macrophages. This suggests that the enantiomers have different intrinsic activities, rather than differing in their vivo metabolism.
Recent progress in high-power blue-violet lasers (2003)

The property of GaInN-AlGaN heterostructures and GaInN multiple quantum well (MQW) gain GaInN laser diodes with low internal loss are described. GaInN blue-violet laser diodes have been developed as a light source for optical disk recording. However, the threshold current density of these diodes has been difficult to reduce and remains high at around 3-4 kA/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . This is thought to be due to the large transparency current density Jt and the large optical internal loss α/sub i/. Recently, the internal loss was successfully reduced to 13.6 cm/sup -1/ by optimizing the design of the near active region and achieved stable continuous operation under 50-mW continuous wave at 70°C. Other laser characteristics such as far-field patterns and laser noise have also been improved for optical disk use.
Direct Methods for Sparse Linear Systems (2006)

Preface 1. Introduction 2. Basic algorithms 3. Solving triangular systems 4. Cholesky factorization 5. Orthogonal methods 6. LU factorization 7. Fill-reducing orderings 8. Solving sparse linear systems 9. CSparse 10. Sparse matrices in MATLAB Appendix: Basics of the C programming language Bibliography Index.