gebhart/patrepeval huggingface dataset:
Interleukin-6 in Schizophrenia—Is There a Therapeutic Relevance? (2017)

Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of IL-6 suggests that this chemical messenger may be responsible for regulating the balance between pro- and anti-inflammatory responses, with tissue-specific properties at the periphery and in the central nervous system. Specific phase of this chronic and deteriorating disorder must be considered, which can involve IL-6 in acute or possible chronic inflammation and/or autoimmunity. We give an overview of IL-6 role in the onset and progression of this disorder, also considering cognitive impairment and metabolic changes in patients with schizophrenia. Data suggest that decreased serum level of IL-6 following antipsychotic therapy could be predisposing factor for the development of obesity and obesity-related metabolic disorders in schizophrenia. As we reviewed, the IL-6 plays significant role in disease genesis and progression, so the use of specific inhibitors may not only be beneficial for exacerbation and alleviation of positive symptoms, but may attenuate cognitive impairment in patients with schizophrenia.
[Radiation response of mitochondria in dependence on their metabolic status (author's transl)]. (1977)

The influence of the metabolic status of mitochondria upon their radiation response was studied. It turned out that the reduction of pyridine nucleotides by addition of beta-hydroxybutyrate (BOH) and the decrease through respiration were distinctly impaired in mitochondria with a substrate deficit by an irradiation with 2.7 krd already. The evolution of the lesion depends on the incubation conditions following irradiation, a presence of BOH having protective effects. The general redox level seems to be essential for radiation response of mitochondria. An exit of NAD from mitochondria has proved to be the main cause for inhibition of the respiratory BOH-consumption.
The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame (1991)

The herpes simplex virus 1 (HSV-1) genome specifies an abundant capsid protein which in denaturing gels forms multiple bands designated family 35 proteins (D.K. Braun, B. Roizman, and L. Pereira, J. Virol. 49:142-153, 1984). Nucleotide-sequencing studies have assigned the coding sequences of these proteins to the open reading frame UL26 (D.J. McGeoch, M.A. Dalrymple, A.J. Davidson, A. Dolan, M.C. Frame, D. McNab, L.J. Perry, J.E. Scott, and P. Taylor, J. Gen. Virol. 69:1531-1574, 1988). IN studies reported here, a series of plasmid constructs containing deletions or insertions of an alpha 4 promoter or of a sequence encoding a cytomegalovirus epitope reacting with a mouse monoclonal antibody revealed the following: the open reading frame previously designated UL26 encodes two proteins which share amino acid sequences, and each coding domain is contained in its own transcriptional unit that terminates at a common, unique poly(A) site. On the basis of the transcription initiation site (+1), it was predicted that the UL26 open reading frame encodes a protein of 635 amino acids, and a protein with an apparent molecular weight of approximately 75,000 has been identified. The second transcriptional unit, designated UL26.5, predicted to specify a protein of 329 amino acids, encodes the family 35 proteins; it is transcribed by an mRNA which initiates at approximately nucleotide +1000 of the UL26 transcription initiation site and is translated from the methionine initiation codon located at position +1099 of the UL26 transcriptional unit. The DNA fragment comprising the sequences downstream of the HpaI cleavage site (+832 of UL26) contains both the promoter and the coding sequence of family 35 proteins and is both competent and efficient in expressing the proteins in transfected cells superinfected with HSV-1 or HSV-2.
Parsing Tables by Probabilistic Modeling of Perceptual Cues (2012)

In this paper, we propose a method for automatically parsing images of tables, focusing in particular on `simple' matrix-like tables with rectilinear layout. Such tables account for over 50% of tables in business documents. The main novelty of the proposed method is that it combines intrinsic properties of table cells with properties of cell separators, as well as table rows, columns, and layout, in a single global objective function. This is in contrast to previous methods which focused on either separators alone or intrinsic cell properties alone. Our method uses a variety of perceptual cues, such as alignment and saliency, to characterize these properties. Candidate parses are evaluated by comparing their likelihoods, and the parse that optimizes the likelihood is selected. The proposed approach deals successfully with a wide variety of tables, as illustrated on a dataset of over 1,000 images.
Effectiveness of sodium hyaluronate eye gel in patients with dry eye disease: A multi-centre, open label, uncontrolled study (2013)

Sodium Hyaluronate can provide a suitable alternate in the treatment of dry eye disease due to its reported efficacy on foreign body sensation, itching, burning, watering, photophobia and feeling of dryness.
The V region sequence of lambda Bence-Jones protein Wh: evidence for separate germ-line sets within lambda-subgroups. (1980)

The complete variable region sequence of the glycosylated Bence-Jones protein Wh has revealed that the most hypervariable segments of the first and third complementarity-determing regions (CDR) are identical with those of another glycosylated Bence-Jones protein (Nei) of the same lambda-subgroup. The carbohydrate is attached in both proteins at the identical sequences in the third CDR, and the sequences of the first CDR differ at only one position in fourteen. Because CDR sequence comparisons more sensitively reflect overall germ-line V gene similarities, proteins Wh and Nei could possibly reflect a "set" relationship analogous to the mouse V kappa isotype. Cluster analyses of currently available V lambda sequences supported this suggested relationship.
Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience (1981)

Ketamine alone or supplemented by diazepam or xylazine has been used and evaluated as an anaesthetic in a range of animals including snakes, tortoises, lizards, birds, ferrets, dogs, cats, pigs, sheep, goats, non-human primates, rabbits, guinea pigs, rats, mice and hamsters. Ketamine alone has severe limitations in most species, but in combination has proved valuable.
Phytic Acid Levels in Seeds of Glycine max and G. soja as Influenced by Phosphorus Status (1993)

Improvement in soybean [ Glycine max (L.) Merr.] nutritional quality may be achieved via a reduction in seed phytic acid P. To advance our knowledge of factors that determine seed phytic acid P levels, the relations between external P availability, leaf or shoot P, and seed P fractions (phytic acid and non‐phytic acid P) were studied in soybean and G. soja (Sieb. &amp; Zucc.) germplasm. Mean phytic acid P varied from 4.3 to 6.2 g P kg −1 in mature seeds of 12 soybean cultivars grown under three field environments. Cultivars ranked similarly in each environment and 98% of the variation in phytic acid P was attributable to a positive, linear effect of available soil P. No significant variation was observed in seed non‐phytic acid P. Similar results were obtained when selected soybean and G. soja lines were grown in sand watered with nutrient solutions containing P concentrations ranging from 2 to 50 mg L −1 . Leaf or shoot P concentrations and seed phytic acid P concentrations were positively correlated and in G. soja were nearly double those observed with indeterminate soybean cultivars. The higher leaf P and seed phytic acid P concentrations in G. soja as compared with indeterminate soybean lines were attributed to reduced P utilization efficiency defined as reduced biomass production per unit of total shoot P. These results indicate that essentially all variation in seed P is found as variation in phytic acid P, and that this variation is related to leaf P concentration in a complex manner determined by genotype and soil P availability.
<title>Object tracking through adaptive correlation</title> (1993)

Current U.S. Air Force interests include a desire to track an object based on its shape once it has been designated as a target. This paper discusses the use of a correlation based system to track an object through a series of images based on templates derived from previous image frames. The ability to track is extended to sequences which include multiple objects of interest within the field of view. This is accomplished by comparing the height and shape of the template autocorrelation to the peaks in the correlation of the template with the next scene. The result is to identify the region in the next scene which best matches the designated target. In addition to correlation plane postprocessing, an adaptive window is used to determine the template size in order to reduce the effects of correlator walk-off. The image sequences used were taken from a Forward Looking Infrared (FLIR) sensor mounted onboard a DC-3 aircraft. The images contain a T-55 tank and both an M-113 and a TAB-71 armored personnel carrier moving in a columnized formation along a dirt road. The goals of this research were to (1) track targets in the presence of other, and sometimes brighter, targets of similar shape; (2) to maintain small tracking errors; and (3) to reduce the effects of correlator walk-off.
Induction of autophagy is essential for monocyte-macrophage differentiation (2012)

Monocytes are programmed to undergo apoptosis in the absence of stimulation. Stimuli that promote monocyte-macrophage differentiation not only cause cellular changes, but also prevent the default apoptosis of monocytes. In the present study, we demonstrate that autophagy is induced when monocytes are triggered to differentiate and that the induction of autophagy is pivotal for the survival and differentiation of monocytes. We also show that inhibition of autophagy results in apoptosis of cells that are engaged in differentiation. We found that the differentiation signal releases Beclin1 from Bcl-2 by activating JNK and blocks Atg5 cleavage, both of which are critical for the induction of autophagy. Preventing autophagy induction hampers differentiation and cytokine production; therefore, autophagy is an important transition from monocyte apoptosis to differentiation.
Dual‐Mode Nanoparticle Probes for High‐Performance Magnetic Resonance and Fluorescence Imaging of Neuroblastoma (2006)

Teamarbeit: Eine „Kern-Satelliten“-Hybridnanopartikel-Sonde ermöglicht dank der synergistischen Verstärkung ihrer Komponenten ein erheblich verbessertes Fluoreszenz- und Magnetresonanz(MR)-Imaging. Diese Hybridnanosonden können für das dual-modale Fluoreszenz- und MR-Imaging von Neuroblastoma mit exprimierten Polysialinsäuren genutzt werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z603052_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A comparative study of the efficacy of Paecilomyces species against root-knot nematode Meloidogyne incognita (2013)

Three Paecilomyces species viz., Paecilomyces variotii, P. lilacinus and P. fumosoroseus were examined at various intensity levels to manage root-knot nematode Meloidogyne incognita. Unlike P. fumosoroseus, increasing concentrations of P. variotii and P. lilacinus culture filtrates considerably inhibited egg-hatching and sustained juvenile transience. Increase in shoot and root weights were observed after applying biocontrol agents in vitro and in vivo on mungbean (Vigna radiata). Significant reductions in number of galls per root system as compared to the control treatment were observed when isolates of P. variotii and P. lilacinus were used. A variation in the efficacy of local isolates of P. variotii was also evident. Plant diseases are the major cause of the downfall of agricultural markets of a country. Meloidogyne species are main parasites of fruit and vegetables. These parasites produce immense physiological as well as morphological disorders and diminish harvest around the globe (Sasser, 1979; Sasser & Carter, 1985; Sasser & Freckman, 1987). In agricultural areas of Pakistan, root-knot nematodes have contaminated nearly all the agricultural and horticultural crops where M. incognita and M. javanica are the most common (Maqbool, 1988; Zarina & Shahina, 2010).
Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts (2016)

We present a sample preparation method for cryo-electron microscopy (cryo-EM) that requires only 3-20nL of sample to prepare a cryo-EM grid, depending on the protocol used. The sample is applied and spread on the grid by a microcapillary. The procedure does not involve any blotting steps, and real-time monitoring allows the water film thickness to be assessed and decreased to an optimum value prior to vitrification. We demonstrate that the method is suitable for high-resolution cryo-EM and will enable alternative electron microscopy approaches, such as single-cell visual proteomics.
A monoclonal antibody that distinguishes phospho- and dephosphorylated forms of cardiac troponin-I (1991)

Conference Article| April 01 1991 A monoclonal antibody that distinguishes phospho- and dephosphorylated forms of cardiac troponin-I BERNADETTE CUMMINS; BERNADETTE CUMMINS 1Department of Physiology, The Medical School, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEOFFREY J. RUSSELL; GEOFFREY J. RUSSELL 1Department of Physiology, The Medical School, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER CUMMINS PETER CUMMINS 1Department of Physiology, The Medical School, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (2): 161S. https://doi.org/10.1042/bst019161s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation BERNADETTE CUMMINS, GEOFFREY J. RUSSELL, PETER CUMMINS; A monoclonal antibody that distinguishes phospho- and dephosphorylated forms of cardiac troponin-I. Biochem Soc Trans 1 April 1991; 19 (2): 161S. doi: https://doi.org/10.1042/bst019161s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Cloning and expression of the complement receptor glycoprotein C from Herpesvirus simiae (herpes B virus): protection from complement-mediated cell lysis (2003)

Simian herpes B virus (SHBV) is the herpes simplex virus (HSV) homologue for the species MACACA: Unlike in its natural host, and unlike other animal herpesviruses, SHBV causes high mortality in accidentally infected humans. SHBV-infected cells, like those infected with HSV-1 and equine herpesvirus types 1 and 4, express complement C3 receptor activity. To study immunoregulatory functions involved in susceptibility/resistance against interspecies transmission, the SHBV glycoprotein C (gC(SHBV)) gene (encoding 467 aa) was isolated. Sequence analysis revealed amino acid identity with gC proteins from HSV-2 (46.9 %), HSV-1 (44.5 %) and pseudorabies virus (21.2 %). Highly conserved cysteine residues were also noted. Similar to gC(HSV-2), gC(SHBV) is less glycosylated than gC(HSV-1), resulting in a molecular mass of 65 kDa if expressed in replication-deficient vaccinia virus Ankara. Stable transfectants expressing full-length gC(SHBV) on the cell surface induced C3 receptor activity and were substantially protected from complement-mediated lysis; no protection was observed with control constructs. This suggests that expression of the gC homologues on infected cell surfaces might also contribute to the survival of infected cells in addition to decreased virion inactivation. Interestingly, soluble gC(SHBV) isolated from protein-free culture supernatants did not interfere with the binding of the alternative complement pathway activator properdin to C3b, which is similar to our findings with gC(HSV-2) and could be attributed to major differences in the amino-terminal portion of the protein with extended deletions in both gC(SHBV) and gC(HSV-2). Binding of recombinant gC(SHBV) to polysulphates was observed. This, together with the heparin-sensitivity of the gC(SHBV)-C3 interaction on the infected cell surface, suggests a role in adherence to heparan sulphate, similar to the gC proteins of other herpesviruses.
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020)

Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012. There are no approved treatments for MERS-CoV infection although a combination of lopinavir, ritonavir and interferon beta (LPV/RTV-IFNb) is currently being evaluated in humans in the Kingdom of Saudi Arabia. Here, we show that remdesivir (RDV) and IFNb have superior antiviral activity to LPV and RTV in vitro. In mice, both prophylactic and therapeutic RDV improve pulmonary function and reduce lung viral loads and severe lung pathology. In contrast, prophylactic LPV/RTV-IFNb slightly reduces viral loads without impacting other disease parameters. Therapeutic LPV/RTV-IFNb improves pulmonary function but does not reduce virus replication or severe lung pathology. Thus, we provide in vivo evidence of the potential for RDV to treat MERS-CoV infections.
Normalized and Differential Convolution : Methods for Interpolation and Filtering of Incomplete and Uncertain Data (1993)

In this paper it is shown how false operator responses due to missing or uncertain data can be significantly reduced or eliminated. Perhaps the most well-known of such effects are the various `edge effects&amp;apos; which invariably occur at the edges of the input data set. Further, it is shown how operators having a higher degree of selectivity and higher tolerance against noise can be constructed using simple combinations of appropriately chosen convolutions. The theory is based on linear operations and is general in that it allows for both data and operators to be scalars, vectors or tensors of higher order. Three new methods are presented: Normalized con-volution, Differential convolution and Normalized Dif-ferential convolution. All three methods are examples of the power of the signal/certainty-philosophy, i.e. the separation of both data and operator into a sig-nal part and a certainty part. Missing data is simply handled by setting the certainty to zero. In the case of uncertain data, an estimate of the certainty must accompany the data. Localization or `windowing&amp;apos; of operators is done using an applicability function, the operator equivalent to certainty, not by changing the actual operator coefficients. Spatially or temporally limited operators are handled by setting the applicability function to zero outside the window. Consistent with the philosophy of this paper all algorithms produce a certainty estimate to be used if further processing is needed. Spectrum analysis is discussed and examples of the performance of gradient, divergence and curl operators are given.
Thiocyanate-Capped PbS Nanocubes: Ambipolar Transport Enables Quantum Dot Based Circuits on a Flexible Substrate (2011)

We report the use of thiocyanate as a ligand for lead sulfide (PbS) nanocubes for high-performance, thin-film electronics. PbS nanocubes, self-assembled into thin films and capped with the thiocyanate, exhibit ambipolar characteristics in field-effect transistors. The nearly balanced, high mobilities for electrons and holes enable the fabrication of CMOS-like inverters with promising gains of ∼22 from a single semiconductor material. The mild chemical treatment and low-temperature processing conditions are compatible with plastic substrates, allowing the realization of flexible, nonsintered quantum dot circuits.
Mycobacterium tuberculosis ( Mtb ) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients (2004)

Proteins released from Mycobacterium tuberculosis (Mtb) during late logarithmic growth phase are often considered candidate components of immunogenic or autolysis markers. One such protein is isocitrate dehydrogenase (ICD), a key regulatory enzyme in the citric acid cycle. We have evaluated the immunogenic properties of two isoforms of Mtb ICD and compared them with the control antigens heat-shock protein 60 and purified protein derivative (PPD). PPD lacks the sensitivity to distinguish between bacillus Calmette-Guérin (BCG)-vaccinated and tuberculosis (TB)-infected populations, and, therefore, epidemiological relevance of PPD in BCG-vaccinated regions is debatable. We show that Mtb ICDs elicit a strong B cell response in TB-infected populations and can differentiate between healthy BCG-vaccinated populations and those with TB. The study population (n = 215) was categorized into different groups, namely, patients with fresh infection (n = 42), relapsed TB cases (n = 32), patients with extrapulmonary TB (n = 35), clinically healthy donors (n = 44), nontuberculous mycobacteria patients (n = 30), and non-TB patients (culture negative for acid-fast bacteria but carrying other infections, n = 32). The Mtb ICDs showed statistically significant antigenic distinction between healthy BCG-vaccinated controls and TB patients (P < 0.0001) and those with other infections. Although extrapulmonary infections could not be discriminated from healthy controls by heat-shock protein 60 (P = 0.2177), interestingly, the Mtb ICDs could significantly (P < 0.0001) do so. Our results highlight the immunodominant, immunosensitive, and immunospecific nature of Mtb ICDs and point to an unusual property of this tricarboxylic acid energy cycle enzyme.