gebhart/patrepeval huggingface dataset:
Adenovirus-mediated decorin gene transfer prevents TGF-β-induced inhibition of lung morphogenesis (1999)

Excessive transforming growth factor (TGF)-beta signaling has been implicated in pulmonary hypoplasia associated with bronchopulmonary dysplasia, a chronic lung disease of human prematurity featuring pulmonary fibrosis. This implies that inhibitors of TGF-beta could be useful therapeutic agents. Because exogenous TGF-beta ligands are known to inhibit lung branching morphogenesis and cytodifferentiation in mouse embryonic lungs in ex vivo culture, we examined the capacity of a naturally occurring inhibitor of TGF-beta activity, the proteoglycan decorin, to overcome the inhibitory effects of exogenous TGF-beta. Intratracheal microinjection of a recombinant adenovirus containing decorin cDNA resulted in overexpression of the exogenous decorin gene in airway epithelium. Although exogenous TGF-beta efficiently decreased epithelial lung branching morphogenesis in control cultures, TGF-beta-induced inhibition of lung growth was abolished after epithelial transfer of the decorin gene. Additionally, exogenous TGF-beta-induced antiproliferative effects as well as the downregulation of surfactant protein C were abrogated by decorin in cultured embryonic lungs. Moreover, lung branching inhibition by TGF-beta could be restored by the addition of decorin antisense oligodeoxynucleotides in culture, indicating that decorin is both specifically and directly involved in suppressing TGF-beta-mediated negative regulation of lung morphogenesis. Our findings suggest that decorin can antagonize bioactive TGF-beta during lung growth and differentiation, establishing the rationale for decorin as a candidate therapeutic approach to ameliorate excessive levels of TGF-beta signaling in the developing lung.
Synchronization of Animal-Inspired Multiple High-Lift Fins in an Underwater Vehicle Using Olivo–Cerebellar Dynamics (2008)

The development of neuroscience-based control methodologies and their integration with the high-lift unsteady hydrodynamics of control surfaces inspired by swimming and flying animals are the subjects of this paper. A biology-inspired rigid autonomous undersea vehicle called the biorobotic autonomous undersea vehicle (BAUV) has been developed at the Naval Undersea Warfare Center (NUWC), Newport, RI. The BAUV is equipped with six simultaneously rolling and pitching fins for generating large unsteady control forces for performing agile maneuvers. First, as an exploratory example, we introduce the van der Pol oscillator as an oscillatory controller for the BAUV and we describe experiments performed to examine the fin forces (thrust and lift) and electric power requirement, and to demonstrate the effectiveness of the oscillator's limit cycle property for disturbance rejection effectiveness. We then describe a BAUV control system that includes six inferior-olive (IO) neuron models for control of the pitch and roll motion of the six foils. These IO neurons exhibit limit cycle oscillation (LCO). For control of the BAUV, these IO neurons must oscillate in synchronism with specific relative phases. We present here four feedback linearizing control systems of varying complexity for control of the relative phases of the IO neurons. It is shown that each of the IO control systems accomplishes asymptotic regulation of the phases and thus enables the foils to produce the required control forces. The first controller has a global synchronization property, but the remaining controllers accomplish local synchronization. We present simulation results for tracking piecewise, time-varying phase angle commands as well as experimental results for control of the BAUV by IO neurons. The results show that with appropriate phasing of the fins, an optimal graceful gait of the BAUV is achieved where no untoward force or moment is present. An analog hardware version of the local controller with a cluster of six IO neurons has also been built, which allows five of the signals to rapidly synchronize to the reference, with or without prescribed phase shift, much like in the simulations. The designed controllers can be used in any platform or multivariate BAUV-like system requiring fast, accurate phase control. Laboratory test results for the phase synchronization of two servomotors (roll and pitch) using the designed analog hardware controller are also shown.
Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. (1990)

A novel cDNA clone (20.5) which is differentially expressed between two closely related T-lymphoma cell clones was isolated by subtraction-enriched differential screening. SL12.4 cells, from which the cDNA was isolated, have characteristics of thymocytes at an intermediate stage in development. A sister cell clone derived from the same tumor, SL12.3, does not express this mRNA, has a distinct phenotype, and expresses fewer genes required for mature T-cell function. The cDNA sequence predicts a highly hydrophobic protein (approximately 49.5 kilodaltons) which contains seven putative membrane spanning domains. The gene was expressed on concanavalin A-activated T lymphocytes and was designated Tea (T-cell early activation gene). The Tea gene mapped to chromosome 8 and appeared to be conserved among mammalian and avian species. The Tea gene is distinct from, but bears extensive amino acid and DNA sequence similarity with, the murine ecotropic retroviral receptor which is encoded by the Rec-1 gene. Neither gene product displayed significant homology with other known transmembrane-spanning proteins. Thus, the Tea and Rec-1 genes establish a new family encoding multiple membrane-spanning proteins.
THE ENZYMATIC SYNTHESIS OF β-ALANYL COENZYME A (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE ENZYMATIC SYNTHESIS OF β-ALANYL COENZYME AE. R. StadtmanCite this: J. Am. Chem. Soc. 1955, 77, 21, 5765–5766Publication Date (Print):November 1, 1955Publication History Published online1 May 2002Published inissue 1 November 1955https://pubs.acs.org/doi/10.1021/ja01626a108https://doi.org/10.1021/ja01626a108research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Recent progress on PLC hybrid integration</title> (1999)

Planar lightwave circuit (PLC) hybrid integration is a promising way to realizing low-cost and highly functional optical components which are integrated with opto-electronic (OE) devices. As low-cost components, WDM hybrid transceiver modules have been developed to construct the fiber-to-the- home networks. As highly functional optical components, a multi-wavelength light source, a high-speed optical wavelength selector and a differential photoreceiver module have been demonstrated to construct optical transmission and switching systems employing dense wavelength-division- multiplexing and time-division-multiplexing technologies. This paper reviews the current status and recent progress on the PLC hybrid integration.
Birefringence in single-mode optical fiber due to elliptical core deformation and stress anisotropy (1980)

A formula for the difference between propagation constants of two polarization modes caused by elliptical core deformation and stress anisotropy is given for single-mode optical fibers. Birefringence in circular and elliptical core fibers subject to an externally applied uniaxial pressure are measured. Birefringence caused by elliptical core deformation and stress anisotropy are experimentally separated by measuring their wavelength dependences. A value of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3.36 \times 10^{-10}</tex> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /gram weight (gw) (= <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3.43 \times 10^{-12}</tex> m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /N) is obtained for the stress-optical constant of silica fibers. Residual stress corresponding to external pressure of 240 gw/cm is observed for a fiber with 0.35 core ellipticity.
Molecular Cloning of Human cDNA with a Sequence Highly Similar to that of the Dihydrofolate Reductase Gene in Brain Libraries Derived from Alzheimer's Disease Patients (1995)

A polyclonal antibody was raised against a serine protease purified from the extracellular fluid of familial Alzheimer's disease lymphoblastoid cells. Using this antibody, a cDNA library from familial Alzheimer's disease cells and two cDNA libraries from the brains of two Alzheimer's disease patients were screened independently. The familial Alzheimer's disease protein 1 (FADP1) cDNA clones isolated from these three libraries were subjected to DNA sequence analysis. The nucleotide sequence of FADP1 cDNA is highly similar to the 5' portion of the human dihydrofolate reductase (DHFR) gene, however, the sequence corresponding to exon 1 of the DHFR gene is completely disrupted and contains a 247-bp DNA insert with a sequence unique to FADP1. Moreover, FADP1 cDNA harbours a large open reading frame, including the unique insert, which has the potential to code an approximately 50-kDa protein. The deduced amino acid sequence of this protein contains 12 cysteine residues potentially involved in six disulfide bonds, a proline-rich segment and a hydrophobic segment. Northern-blot analysis with the unique insert DNA probe verified that FADP1 protein is expressed in both lymphoblastoid and brain cells derived from Alzheimer's disease patients.
Action capture with accelerometers (2008)

We create a performance animation system that leverages the power of low-cost accelerometers, readily available motion capture databases, and construction techniques from e-textiles. Our system, built with only off-the-shelf parts, consists of five accelerometers sewn into a comfortable shirt that streams data to a computer. The accelerometer readings are continuously matched against accelerations computed from existing motion capture data, and an avatar is animated with the closest match. We evaluate our system visually and using simultaneous motion and accelerometer capture.
Limitations of Encapsidation of Recombinant Self-Complementary Adeno-Associated Viral Genomes in Different Serotype Capsids and Their Quantitation (2012)

We previously reported that self-complementary adeno-associated virus (scAAV) type 2 genomes of up to 3.3 kb can be successfully encapsidated into AAV2 serotype capsids. Here we report that such oversized AAV2 genomes fail to undergo packaging in other AAV serotype capsids, such as AAV1, AAV3, AAV6, and AAV8, as determined by Southern blot analyses of the vector genomes, although hybridization signals on quantitative DNA slot-blots could still be obtained. Recently, it has been reported that quantitative real-time PCR assays may result in substantial differences in determining titers of scAAV vectors depending on the distance between the primer sets and the terminal hairpin structure in the scAAV genomes. We also observed that the vector titers determined by the standard DNA slot-blot assays were highly dependent on the specific probe being used, with probes hybridizing to the ends of viral genomes being significantly overrepresented compared with the probes hybridizing close to the middle of the viral genomes. These differences among various probes were not observed using Southern blot assays. This overestimation of titer is a systemic error during scAAV genome quantification, regardless of viral genome sequences and capsid serotypes. Furthermore, different serotypes capsid and modification of capsid sequence may affect the ability of packaging intact, full-length AAV genomes. Although the discrepancy is modest with wild-type serotype capsid and short viral genomes, the measured titer could be as much as fivefold different with capsid mutant vectors and large genomes. Thus, based on our data, we suggest that Southern blot analyses should be performed routinely to more accurately determine the titers of recombinant AAV vectors. At the very least, the use of probes/primers hybridizing close to the mutant inverted terminal repeat in scAAV genomes is recommended to avoid possible overestimation of vector titers.
Optimal decentralized protocol for electric vehicle charging (2013)

We propose a decentralized algorithm to optimally schedule electric vehicle (EV) charging. The algorithm exploits the elasticity of electric vehicle loads to fill the valleys in electric load profiles. We first formulate the EV charging scheduling problem as an optimal control problem, whose objective is to impose a generalized notion of valley-filling, and study properties of optimal charging profiles. We then give a decentralized algorithm to iteratively solve the optimal control problem. In each iteration, EVs update their charging profiles according to the control signal broadcast by the utility company, and the utility company alters the control signal to guide their updates. The algorithm converges to optimal charging profiles (that are as “flat” as they can possibly be) irrespective of the specifications (e.g., maximum charging rate and deadline) of EVs, even if EVs do not necessarily update their charging profiles in every iteration, and use potentially outdated control signal when they update. Moreover, the algorithm only requires each EV solving its local problem, hence its implementation requires low computation capability. We also extend the algorithm to track a given load profile and to real-time implementation.
Ruthenium-Catalyzed Cycloaddition of Aryl Azides and Alkynes (2007)

The formation of 1,5-disubstituted 1,2,3-triazoles from aryl azides and alkynes was readily accomplished using [Cp*RuCl]4 catalyst in dimethylformamide. It was also demonstrated that the reaction provided higher yields, cleaner product, and shorter reaction times when carried out under microwave irradiation.
Phase Congruency Detects Corners and Edges (2003)

Abstract. There are many applications such as stereo matching, motion tracking and image registration that require so called ‘corners ’ to be detected across image sequences in a reliable manner. The Harris corner detector is widely used for this purpose. However, the response from the Harris operator, and other corner operators, varies considerably with image contrast. This makes the setting of thresholds that are appropriate for extended image sequences difficult, if not impossible. This paper describes a new corner and edge detector developed from the phase congruency model of feature detection. The new operator uses the principal moments of the phase congruency information to determine corner and edge information. The resulting corner and edge operator is highly localized and has responses that are invariant to image contrast. This results in reliable feature detection under varying illumination conditions with fixed thresholds. An additional feature of the operator is that the corner map is a strict subset of the edge map. This facilitates the cooperative use of corner and edge information. 1
Viewpoint Invariant Face Recognition using Independent Component Analysis and Attractor Networks (1996)

We have explored two approaches to recognizing faces across changes in pose. First, we developed a representation of face images based on independent component analysis (ICA) and compared it to a principal component analysis (PCA) representation for face recognition. The ICA basis vectors for this data set were more spatially local than the PCA basis vectors and the ICA representation had greater invariance to changes in pose. Second, we present a model for the development of viewpoint invariant responses to faces from visual experience in a biological system. The temporal continuity of natural visual experience was incorporated into an attractor network model by Hebbian learning following a lowpass temporal filter on unit activities. When combined with the temporal filter, a basic Hebbian update rule became a generalization of Griniasty et al. (1993), which associates temporally proximal input patterns into basins of attraction. The system acquired representations of faces that were largely independent of pose.
Cross-linked iron dextran is an efficient oral phosphate binder in the rat (1996)

The results demonstrate an excellent phosphate-binding capacity of the material and a good tolerance during the intestinal passage. No significant chemical or enzymatic degradation, histological alterations, or other treatment-related macroscopic findings were recorded. The present efficacy and toxicity study has shown effective phosphate binding with no toxicity and no iron release after ingestion of this novel phosphate binding agent. We propose clinical evaluation studies to assess whether similar efficacy and safety can be shown in humans.
Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment (2003)

A case of biopsy verified progressive multifocal leucoencephalopathy (PML) in an HIV patient is presented. Imaging and histological examination confirmed remarkable inflammatory activity accompanied by an unusually benign clinical course despite no clear evidence of immune reconstitution after the start of antiretroviral treatment. This case not only raises several questions regarding the pathophysiology of PML, but gives also evidence that AIDS associated inflammatory PML must be considered another clinical entity in the expanding range of diseases now commonly referred to as the immune reconstitution syndrome.
Analysis of the human Ig isotype response to lactoferrin binding protein A from Neisseria meningitidis (1999)

An effective vaccine for serogroup B meningococci has yet to be developed and attention has turned to subcapsular antigens of the meningococcus as possible vaccine candidates. Iron binding proteins are being studied, with most interest focused on the transferrin binding proteins (TbpA and TbpB) and the ferric binding protein (FbpA). This study describes the purification of lactoferrin binding protein A (LbpA) from two meningococcal strains and assesses the human isotype-specific serum antibody response to these proteins in patients with proven meningococcal disease due to a range of phenotypes. Overall, fewer than 50% of sera contained IgG that recognised LbpA isolated from either strain and this antibody response was not uniform between the two proteins. There was some evidence that the antibody response varied between meningococcal phenotypes. This study demonstrates that LbpA does not induce a highly cross-reactive antibody response, indicating that it is unlikely to be an effective vaccine antigen.
The Metaphors of Retirement : Cutting Cords, Disentangling from Webs, and Heading for Pasture (1995)

Pondy (1983) states, "Metaphors help to organize the objective facts of the situation in the minds of the participants" (p. 157). This investigation sought to provide insight into how actors viewed retirement by uncovering and analyzing metaphors associated with retirement. Differences in the metaphors used by retirees and non retirees were also examined. Retirees used metaphors which indicated that "Transition," "Emotion," "Freedom," and "Shedding Weight" are a significant part of the retirement experience. This study suggests that metaphor analysis provides a richly varied and salient source of information about social actors' perceptions of organizational retirement.
Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck. (1990)

Antibody-mediated CD4 crosslinking results in increased tyrosine phosphorylation and tyrosine kinase activity of the associated p56lck. Treatment with anti-CD4 and anti-Ig also induced the phosphorylation of p56lck in a CD45- mutant cell line, indicating that the increase in phosphotyrosine content of p56lck is not the result of being sequestered from CD45 protein tyrosine phosphatase (PTPase). Antibody-mediated coclustering of CD45 with CD4 inhibited the anti-CD4-induced phosphorylation of p56lck on tyrosine and the concomitant increase in in vitro kinase activity. Similar results were obtained when CD45 was coclustered with CD8 on cytotoxic T cell lines. These observations provide strong evidence that p56lck is a substrate for CD45 in vivo and provide an assay to study the regulation and specificity of CD45 PTPase activity.
Acute Onset and Worsening of Diabetes Concurrent with Administration of Statins (2005)

We report a patient in whom the administration of HMG CoA reductase inhibitors (statins) might have triggered the onset and worsening of diabetes. The patient was a 48-year-old Japanese man who underwent annual medical examination but had never been told of hyperglycemia. Four months after the commencement of atorvastatin (10 mg/day) treatment, a diagnosis of diabetes mellitus was made from his typical symptoms of hyperglycemia, postprandial plasma glucose level of 29.8 mmol/l and HbA1c of 11.5%. After 2 months of insulin therapy and 3 months after the cessation of atorvastatin, almost complete resolution of diabetes was observed. During the subsequent 3 months, diet therapy alone was sufficient to control blood glucose level. Then, we prescribed pravastatin (20 mg/day). During the subsequent 3 months, HbA1c was gradually increased. However, after discontinuation of pravastatin, HbA1c was gradually decreased. In the general population, statin does not seem to have critical adverse effects on glucose tolerance, but it may uncommonly modify the natural course of the development of diabetes in certain patients.