gebhart/patrepeval huggingface dataset:
Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen) (2003)

Mantle cell lymphoma (MCL) is rarely cured with standard-dose chemotherapy. From January 1997 to February 2000, 28 previously untreated advanced-stage MCL patients younger than 61 years of age were treated at 9 Italian hematologic departments with 3 cycles of standard-dose debulking chemotherapy followed by a high-dose rituximab-supplemented sequence (R-HDS) including intravenous administration of high-dose cyclophosphamide, high-dose cytarabine, high-dose melphalan, and high-dose mitoxantrone plus melphalan. Study end points included toxicity, clinical and molecular response rates, long-term event-free survival (EFS), and overall survival (OS) rates, as well as the ability to harvest tumor-free peripheral blood stem cells. Optimal amounts of polymerase chain reaction-negative (PCR-negative) CD34+ cells were collected from all 20 informative patients. One patient died of toxicity. All 27 patients assessable for response achieved a complete response (CR), of which 24 remain in continuous complete remission (CCR) after a median follow-up of 35 months. Three patients had transient evidence of PCR-detectable disease in the bone marrow. The OS and EFS rates at 54 months were 89% and 79%, respectively. These results compare with the 42% OS rate and the 18% EFS rate observed in 35 age-matched historic controls treated with standard-dose chemotherapy at the participating centers. The use of rituximab in combination with high-dose chemotherapy represents a very effective in vivo purging method. The R-HDS regimen can be safely applied in a multicenter hematology setting and leads to long-term EFS and OS in the majority of patients with an otherwise incurable disease.
Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity (1985)

CC-1065 is a unique antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of this drug are thought to be due to its ability to form a covalent adduct with DNA through N3 of adenine. Thermal treatment of CC-1065-DNA adducts leads to DNA strand breakage. We have shown that the CC-1065 structural modification of DNA that leads to DNA strand breakage is related to the primary alkylation site on DNA. The thermally induced DNA strand breakage occurs between the deoxyribose at the adenine covalent binding site and the phosphate on the 3' side. No residual modification of DNA is detected on the opposite strand around the CC-1065 lesion. Using the early promoter element of SV40 DNA as a target, we have examined the DNA sequence specificity of CC-1065. A consensus sequence analysis of CC-1065 binding sites on DNA reveals two distinct classes of sequences for which CC-1065 is highly specific, i.e., 5'PuNTTA and 5'AAAAA. The orientation of the DNA sequence specificity relative to the covalent binding site provides a basis for predicting the polarity of drug binding in the minor groove. Stereo drawings of the CC-1065-DNA adduct are proposed that are predictive of features of the CC-1065-DNA adduct elucidated in this investigation.
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression (2004)

IL-15 and the IL-15 receptor (IL-15R)alpha chain are essential for normal development of naive CD8 T cells, intestinal intraepithelial lymphocytes (IEL), and natural killer (NK)/NK/T cells. However, whether IL-15R alpha expression by these subsets is necessary for their production and which cell type needs to produce IL-15 to drive development are unknown. We analyzed the requirements for IL-15 and IL-15R alpha expression by bone marrow-derived or parenchymal cells for mediating lymphocyte subset development. Naive CD8 T cell development required IL-15R alpha expression by both bone marrow-derived and parenchymal cells, whereas memory-phenotype CD8 T cells required IL-15R alpha expression only by hematopoietic cells. In contrast and surprisingly, the development of IEL subsets, particularly CD8 alpha alpha Thy1(-)V gamma 5(+) T cell antigen receptor gamma delta and the CD8 alpha alpha Thy1(-) T cell antigen receptor alpha beta IEL populations, depended completely on parenchymal cell expression of IL-15R alpha and IL-15 but not IL-15R beta. In the case of NK and NK/T cell generation and maturation, expression of IL-15 and IL-15R alpha by both parenchymal and hematopoietic cells was important, although the latter played the greatest role. These results demonstrated dichotomous mechanisms by which IL-15 regulated lymphoid development, interacting with distinct cell types depending on the developmental pathway.
Efficient, robust, and fast global motion estimation for video coding (2000)

In this paper, we propose an efficient, robust, and fast method for the estimation of global motion from image sequences. The method is generic in that it can accommodate various global motion models, from a simple translation to an eight-parameter perspective model. The algorithm is hierarchical and consists of three stages. In the first stage, a low-pass image pyramid is built. Then, an initial translation is estimated with full-pixel precision at the top of the pyramid using a modified n-step search matching. In the third stage, a gradient descent is executed at each level of the pyramid starting from the initial translation at the coarsest level. Due to the coarse initial estimation and the hierarchical implementation, the method is very fast. To increase robustness to outliers, we replace the usual formulation based on a quadratic error criterion with a truncated quadratic function. We have applied the algorithm to various test sequences within an MPEG-4 coding system. From the experimental results we conclude that global motion estimation provides significant performance gains for video material with camera zoom and/or pan. The gains result from a reduced prediction error and a more compact representation of motion. We also conclude that the robust error criterion can introduce additional performance gains without increasing computational complexity.
Gonadotrophin glycosylation and function (1990)

This review emphasizes the heterogeneous structure of the gonadotrophin hormones and the influence of different oligosaccharide structures on the bioactivity of these hormones. A summary has been made of the changes in biopotency of the gonadotrophins throughout the life-cycle of the human and in different endocrine states in the rat. In general it appears that the charge of the gonadotrophin conferred by the acid radicals attached to the terminal groups on the oligosaccharide structures strongly influences biopotency. Basic structures have a greater potency in in-vitro assays, but a short half-life in the circulation, while acidic isoforms are less potent, but have a longer circulatory time and are thus more active in in-vivo estimations. More basic forms are secreted over the adult reproductive years compared with the prepubertal period and old age. The glycosyl structure of the carbohydrate groups also alters in different endocrine states and is probably also important for the bioactivity and potency of the hormone. Gonadotrophin-releasing hormone (GnRH) and gonadal steroids can influence the type of isoform synthesized and released, and therefore affect the function of gonadotrophins. GnRH enhances glycosylation, sulphation and biopotency. Oestradiol potentiates the glycosylation induced by GnRH and reduces sialylation, while testosterone increases sialylation.
Current indications for caval interruption: should they be liberalized in view of improving technology? (1996)

Although the impressive increase in the number of filters placed since 1988 is not surprising, it is appropriate to continue to review the indications for placement to determine whether abuse of these devices is occurring. Initially, there were very stringent requirements that were appropriate because there were few data to evaluate the efficacy and safety of the device. Now, data have been accumulated indicating the Greenfield filter has a high degree of efficacy (95%) and comparable caval patency (96%)32 for 20 years.1 Knowing that the filter is safe and effective, physicians are electing to place it in patients with greater comorbidity factors or with longer life-expectancy. In addition, advances in the treatment of patients with multiple trauma and malignancy have resulted in improved survival, leaving more patients at risk of DVT and PE. Finally, the number of patients older than age 60 is increasing rapidly, and the number of elective and emergent orthopaedic procedures is growing. All of these factors have led to an increased number of filter placements that should be considered appropriate. Although there are certainly cases in which the filter was placed without sufficient justification, the explosion in use can more accurately be correlated with changes in medical care, the established efficacy and safety of the device, the growing numbers of patients diagnosed with thromboembolism, and the increased awareness of the risk of complications from anticoagulation. When filter placement is preceded by a careful assessment of the patient to determine the risks and benefits of alternative treatments, there is little danger of abuse. However, more clinical investigation will be necessary to determine the optimal, cost-effective approach in situations in which controversy currently exists.
Pro WF: Windows Workflow in NET 3.5 (2007)

Windows Workflow Foundation (WF) is a revolutionary part of the .NET 4 Framework that allows you to orchestrate human and system interactions as a series of workflows that can be easily mapped, analyzed, adjusted, and implemented. As business problems become more complex, the need for workflow-based solutions has never been more evident. WF provides a simple and consistent way to model and implement complex problems. As a developer, you focus on developing the business logic for individual workflow tasks. The runtime handles the execution of those tasks after they have been composed into a workflow. Pro WF: Windows Workflow in .NET 4 provides you with the skills you need to incorporate WF in your applications, using a lively tutorial style with each example illustrated in C#. This book gets you up to speed with WF 4 quickly and comprehensively. Learn about WF 4's new designer, it's updated programming paradigm, and the completely new set of activities that can enable and extend your workflows. This book also includes detailed coverage of how to customize your workflows and access them in a variety of ways and situations so you can maximize the advantages of this technology.
Developing mRNA-vaccine technologies (2012)

mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity while not subject to MHC haplotype restriction. In addition, mRNA is an intrinsically safe vector as it is a minimal and only transient carrier of information that does not interact with the genome. Because any protein can be expressed from mRNA without the need to adjust the production process, mRNA vaccines also offer maximum flexibility with respect to development. Taken together, mRNA presents a promising vector that may well become the basis of a game-changing vaccine technology platform. Here, we outline the current knowledge regarding different aspects that should be considered when developing an mRNA-based vaccine technology.
Advances and challenges in malaria vaccine development (2010)

Malaria caused by Plasmodium falciparum remains a major public health threat, especially among children and pregnant women in Africa. An effective malaria vaccine would be a valuable tool to reduce the disease burden and could contribute to elimination of malaria in some regions of the world. Current malaria vaccine candidates are directed against human and mosquito stages of the parasite life cycle, but thus far, relatively few proteins have been studied for potential vaccine development. The most advanced vaccine candidate, RTS,S, conferred partial protection against malaria in phase II clinical trials and is currently being evaluated in a phase III trial in Africa. New vaccine targets need to be identified to improve the chances of developing a highly effective malaria vaccine. A better understanding of the mechanisms of naturally acquired immunity to malaria may lead to insights for vaccine development.
Narrow Bandwidth Luminescence from Blends with Energy Transfer from Semiconducting Conjugated Polymers to Europium Complexes (1999)

Efficient, pure red-emitting polymer light-emitting diodes have been prepared by doping blue-emitting conjugated polymers with europium β-diketonate complexes (see Figure). The pure red emission is required for full color displays, while the blends are also expected to be useful as emitters in photonic crystals due to their narrow monochromaticity (see also cover).
Computation of flows around a karman-trefftz profile : (preprint) (1981)

In this report we consider the stationary Navier-Stokes equations in w -w formulation.The equations are discretized with Il'in's method and Newton-linearized.Each linear system is solved by the multigrid method.Il'in's method induces artificial viscosity, especially in regions with large 2nd derivatives of the vorticity (e.g. in boundary layers).To reduce this artificial viscosity mesh refinement is applied in those regions.The flows in a square cavity and around a cylinder are computed.These are test problems for a more practical problem: the flow around a Karman-Trefftz profile, which is also computed.
Quantum theory of a bandpass Purcell filter for qubit readout (2015)

The measurement fidelity of superconducting transmon and Xmon qubits is partially limited by the qubit energy relaxation through the resonator into the transmission line, which is also known as the Purcell effect. One way to suppress this energy relaxation is to employ a filter which impedes microwave propagation at the qubit frequency. We present semiclassical and quantum analyses for the bandpass Purcell filter realized by E. Jeffrey et al. [Phys. Rev. Lett. 112, 190504 (2014)]. For typical experimental parameters, the bandpass filter suppresses the qubit relaxation rate by up to two orders of magnitude while maintaining the same measurement rate. We also show that in the presence of a microwave drive the qubit relaxation rate further decreases with increasing drive strength.
A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients (2013)

This is the first study to integrate genetic aberration, genome-wide RNAi data, and mRNA expression data to identify a functional gene set that predicts which resectable patients with non-small cell lung cancer will have a survival benefit with ACT.
DCTCP: Efficient Packet Transport for the Commoditized Data Center (2010)

Cloud data centers host diverse applications, mixing in the same network a plethora of workflows that require small predictable latency with others requiring large sustained throughput. In this environment, today’s state-of-the-art TCP protocol falls short. We present measurements of a 6000 server production cluster and reveal network impairments, such as queue buildup, buffer pressure, and incast, that lead to high application latencies. Using these insights, propose a variant of TCP, DCTCP, for data center networks. DCTCP leverages Explicit Congestion Notification (ECN) and a simple multibit feedback mechanism at the host. We evaluate DCTCP at 1 and 10Gbps speeds, through benchmark experiments and analysis. In the data center, operating with commodity, shallow buffered switches, DCTCP delivers the same or better throughput than TCP, while using 90 % less buffer space. Unlike TCP, it also provides hight burst tolerance and low latency for short flows. While TCP’s limitations cause our developers to restrict the traffic they send today, using DCTCP enables the applications to handle 10X the current background traffic, without impacting foreground traffic. Further, a 10X increase in foreground traffic does not cause any timeouts, thus largely eliminating incast problems. 1.
Singular value decomposition based low-footprint speaker adaptation and personalization for deep neural network (2014)

The large number of parameters in deep neural networks (DNN) for automatic speech recognition (ASR) makes speaker adaptation very challenging. It also limits the use of speaker personalization due to the huge storage cost in large-scale deployments. In this paper we address DNN adaptation and personalization issues by presenting two methods based on the singular value decomposition (SVD). The first method uses an SVD to replace the weight matrix of a speaker independent DNN by the product of two low rank matrices. Adaptation is then performed by updating a square matrix inserted between the two low-rank matrices. In the second method, we adapt the full weight matrix but only store the delta matrix - the difference between the original and adapted weight matrices. We decrease the footprint of the adapted model by storing a reduced rank version of the delta matrix via an SVD. The proposed methods were evaluated on short message dictation task. Experimental results show that we can obtain similar accuracy improvements as the previously proposed Kullback-Leibler divergence (KLD) regularized method with far fewer parameters, which only requires 0.89% of the original model storage.
Cytokines as adjuvants: Effect on the immunogenicity of NeuAcα2‐6GalNAcα‐O‐Ser/Thr (sialyl‐Tn) (1993)

Sialyl-Tn, defined by monoclonal antibody (MAb) B72.3, shows restricted normal-tissue distribution but is expressed in a wide variety of carcinomas. To analyze the immunogenicity of sialyl-Tn, mice were immunized with ovine submaxillary mucin (OSM) in combination with monophosphoryl lipid A (MPLA), liposomes, or adjuvants that activate macrophages (rIL-1, rIFN-gamma, rM-CSF, IL-1-derived peptides) or T cells (rIL-2). The level and specificity of the immune response were analyzed by ELISA. rIL-1 and rIFN-gamma induced a very high and specific antibody response, whereas the effect of rM-CSF was dose-dependent: at a low dose it induced a high-level specific antibody response and at the high dose level it induced a polyclonal non-specific response. These results indicate that cytokines are powerful adjuvants which modulate both the magnitude and specificity of the immune response. More studies are necessary to determine the optimal doses in animal models and in active specific immunotherapy of patients with cancer.
Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma (2013)

The A2b receptor (A2bR) belongs to the adenosine receptor family. Emerging evidence suggest that A2bR is implicated in tumor progression in some murine tumor models, but the therapeutic potential of targeting A2bR in melanoma has not been examined. This study first shows that melanoma-bearing mice treated with Bay 60-6583, a selective A2bR agonist, had increased melanoma growth. This effect was associated with higher levels of immune regulatory mediators interleukin-10 (IL-10) and monocyte chemoattractant protein 1 (MCP-1) and accumulation of tumor-associated CD11b positive Gr1 positive cells (CD11b(+)Gr1(+)) myeloid-derived suppressor cells (MDSCs). Depletion of CD11b(+)Gr1(+) cells completely reversed the protumor activity of Bay 60-6583. Conversely, pharmacological blockade of A2bR with PSB1115 reversed immune suppression in the tumor microenvironment, leading to a significant melanoma growth delay. PSB1115 treatment reduced both levels of IL-10 and MCP-1 and CD11b(+)Gr1(+) cell number in melanoma lesions. These effects were associated with higher frequency of tumor-infiltrating CD8 positive (CD8(+)) T cells and natural killer T (NKT) cells and increased levels of T helper 1 (Th1)-like cytokines. Adoptive transfer of CD11b(+)Gr1(+) cells abrogated the antitumor activity of PSB1115. These data suggest that the antitumor activity of PSB1115 relies on its ability to lower accumulation of tumor-infiltrating MDSCs and restore an efficient antitumor T cell response. The antitumor effect of PSB1115 was not observed in melanoma-bearing nude mice. Furthermore, PSB1115 enhanced the antitumor efficacy of dacarbazine. These data indicate that A2bR antagonists such as PSB1115 should be investigated as adjuvants in the treatment of melanoma.
Linear optical amplifier (2002)

Amplification in metro networks sets new requirements on amplifier performance. Amplifiers that meet the cost, power and size requirements can enable metro networks in terms of performance and functionality. Device and system tests results demonstrate the metro network capability of linear optical amplifiers.
Single-domain antibodies for biomedical applications (2015)

Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. This class of antibody derivatives comprises naturally occurring variable domains derived from camelids and sharks as well as engineered human variable or constant antibody domains of the heavy or light chain. Because of their high affinity and specificity as well as stability, small size and benefit of multiple re-formatting opportunities, those molecules emerged as promising candidates for biomedical applications and some of these entities have already proven to be successful in clinical development.
Monitoring of structural systems by using frequency data (1999)

The present work evaluates the possibility of using dynamic data to assess structural integrity. It addresses the problem of understanding when it is sufficient to measure and use only natural frequencies, thus avoiding the need to measure modal shapes. The classic problem of detecting damage in beams, or beam assemblies, due to concentrated cracks, or damage spread over a structural member is dealt with. Damage is represented as a decrease in stiffness and linear behaviour before and after the event assumed to have caused damage is considered. Damage is restricted to a few unknown sections or elements, so that only the modification of few parameters of the system need to be determined. This study thus rejects assumptions unrelated to the physical aspects of the problem, in contrast to many papers on the subject. The amount of data to locate and quantify damage correctly is discussed; general considerations lead to the conclusion that a unique and reliable estimate of the damage can be obtained using only few additional frequency data with respect to the number of damaged zones. Continuous and discrete (finite element) models are examined. Finally the paper considers the applications to both analytical and experimental data of the procedure developed, which takes account of the peculiar characteristics of damage detection problem. Copyright © 1999 John Wiley & Sons, Ltd.