gebhart/patrepeval huggingface dataset:
An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Preliminary results (2004)

3512 Background: Cetuximab (Erbitux) is an IgG1 monoclonal antibody targeting the EGFR, shown to be effective in patients (pts) with EGFR-expressing metastatic CRC refractory to prior irinotecan-based chemotherapy (Cunningham ASCO 2003). Cetuximab has demonstrated high efficacy with an acceptable safety profile in combination with different regimens of irinotecan/FA/5-FU as 1st-line treatment (Rosenberg ASCO 2002; Van Laethem and Folprecht ASCO 2003). This trial was designed to evaluate the efficacy and safety of cetuximab with the FOLFOX-4 regimen as 1st-line treatment. Methods: Pts received cetuximab (400 mg/m2 week 1 and 250 mg/m2 weekly thereafter) plus FOLFOX-4 (every 2 weeks: oxaliplatin 85 mg/m2, day 1; FA 200 mg/m2 IV 2h and 5-FU 400 mg/m2 IV bolus followed by 600 mg/m2 IV for 22h, days 1 and 2) until PD or unacceptable toxicity. Main inclusion criteria included pts with non-resectable metastatic CRC, EGFR expression on tumor, no previous chemotherapy for metastatic CRC, and ECOG PS = 2. Results: Of the 61 pts screened 50 (82%) showed EGFR expression on the tumor. 43 pts have finally been enrolled. Currently, baseline data from 25 enrolled pts are available: M/F 16/9, median age 65 years (range 43–75), colon/rectum 17/8, ECOG PS=0/1 16/9, number of organs affected=1/2/3: 13/9/3. The observed best overall response was based on 20 evaluable pts: 14 (70%) partial response (of these, 7 responses have been confirmed so far), 5 (25%) stable disease, 1 not evaluable who withdrew his consent after 1st infusion. Two pts underwent curative resection of their hepatic metastasis after confirmed response. So far, 8 serious adverse events were observed (4 5-FU related diarrhea, 1 pulmonary embolism, 1 pneumonia, 1 PD with obstructive jaundice, 1 gout) none of them related to cetuximab. Conclusion: These preliminary data suggest that cetuximab may be safe and effective when combined with FOLFOX-4 in first-line treatment of patients with metastatic CRC. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Merck Farma y Quimica, S.A; Merck KGaA Merck KGaA Merck KGaA
Single-agent paclitaxel in advanced anal cancer after failure of cisplatin and 5-fluorouracil chemotherapy. (2011)

Squamous cell cancer of the anal canal (anal cancer) is a rare disease but with worldwide increasing incidence. While combined therapy of 5-fluorouracil (5-FU), mitomycin, and radiation is the treatment of choice for locoregional anal cancer, the treatment of metastatic disease is less established. 5-FU and cisplatin combination has been adopted as the first-line treatment of choice for metastatic disease based on several phase II studies. However, no standard therapy has been established for stage IV anal cancer after the failure of this combination. Paclitaxel, a microtubule-stabilizing chemotherapeutic agent, has established clinical activity in squamous cell cancer of the head and neck. One prior report described the activity of paclitaxel in five patients with anal cancer. In this report, we describe our experience using this agent in seven patients suffering from metastatic anal cancer with prior progression on cisplatin and 5-FU. Four patients had an objective response and one patient experienced stable disease. Our results confirm activity of weekly-paclitaxel in patients with 5-FU and cisplatin-resistant metastatic anal cancer.
Diffractive narrow-band transmission filters based on guided-mode resonance effects in thin-film multilayers (1997)

New possibilities for realization of narrow-band transmission filters are introduced. Guided-mode resonance effects in thin-film multilayer structures incorporating a grating layer are shown to yield high-efficiency bandpass transmission filters. Calculated transmission characteristics for such filters are presented and contrasted with characteristics of corresponding thin-film interference filters.
Jamming-Resistant Collaborative Broadcast Using Uncoordinated Frequency Hopping (2011)

We propose a jamming-resistant collaborative broadcast scheme for wireless networks, which utilizes the Un coordinated Frequency Hopping (UFH) technique to counteract jamming without preshared keys, and exploits node cooperation to achieve higher communication efficiency and stronger jamming resistance. In this scheme, nodes that already obtain the broadcast message serve as relays to help forward it to other nodes. Relying on the sheer number of relay nodes, our scheme provides a new angle for jamming countermeasure, which not only significantly enhances the performance of jamming-resistant broadcast, but can readily be combined with other existing or emerging antijamming approaches in various applications. We present the collaborative broadcast protocol, and analyze its successful packet reception rate and the corresponding cooperation gain for both synchronous and asynchronous relays for a snapshot scenario. We also investigate the full broadcast process based on a Markov chain model and derive a closed-form expression of the average broadcast delay. Simulation results in both single-hop and multihop networks indicate that our scheme is a promising antijamming technique in wireless networks.
Dentists’ decisions on prophylactic removal of mandibular third molars: a 10‐year follow‐up study (2001)

In the decisions on prophylactic removal of mandibular third molars, there has been no change over the last 10 years towards a more noninterventionist attitude. Thus, the dentists seem not to have been influenced by the evidence that this intervention is not cost-effective.
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects (2012)

Engineered zinc finger nucleases (ZFNs) induce DNA double-strand breaks at specific recognition sequences and can promote efficient introduction of desired insertions, deletions or substitutions at or near the cut site via homology-directed repair (HDR) with a double- and/or single-stranded donor DNA template. However, mutagenic events caused by error-prone non-homologous end-joining (NHEJ)-mediated repair are introduced with equal or higher frequency at the nuclease cleavage site. Furthermore, unintended mutations can also result from NHEJ-mediated repair of off-target nuclease cleavage sites. Here, we describe a simple and general method for converting engineered ZFNs into zinc finger nickases (ZFNickases) by inactivating the catalytic activity of one monomer in a ZFN dimer. ZFNickases show robust strand-specific nicking activity in vitro. In addition, we demonstrate that ZFNickases can stimulate HDR at their nicking site in human cells, albeit at a lower frequency than by the ZFNs from which they were derived. Finally, we find that ZFNickases appear to induce greatly reduced levels of mutagenic NHEJ at their target nicking site. ZFNickases thus provide a promising means for inducing HDR-mediated gene modifications while reducing unwanted mutagenesis caused by error-prone NHEJ.
In vivo Noninvasive Evaluation of Hairless Rat Skin after High-Voltage Pulse Exposure (1998)

Short high-voltage pulses have recently been shown to dramatically increase and expedite transdermal drug transport via a mechanism hypothesized to involve electroporation. This study addresses tolerance issues of the method in vivo in hairless rat. Chromametry, transepidermal water loss (TEWL), laser Doppler flowmetry (LDF) and corneometry were jointly used for noninvasive sensing of skin biophysical parameters. Slight increases in skin redness, TEWL and LDF values followed the application of electric pulses. The changes in skin capacitance were nonsignificant. The magnitude of the alterations depended on the electrical features of the pulses. When compared to iontophoresis, high-voltage pulses did not induce stronger alterations of skin functions. This report provides the first in vivo demonstration of the safety of the high-voltage pulses proposed for transdermal delivery.
The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study (2007)

clinicaltrials.gov NCT00324909.
Levodopa‐induced dyskinesias in Parkinson's disease phenomenology and pathophysiology (1994)

The aim of this study was to provide further insight into the phenomenology and pathophysiology of monophasic and biphasic dyskinesias induced by levodopa in Parkinson's disease. For this purpose, the type, localization, severity, and timing of dyskinesias were evaluated in 15 parkinsonian patients in relation to motor disability after administration of levodopa using a video-electromyographic recording device. Foot-dystonia, myoclonus, and akathisia were observed in most patients. The dyskinesias started in the foot, usually on the side most affected by the disease, and spread in an "ascending wave" to the contralateral side, the trunk, and upper extremities. In a few patients, onset was axial, spreading almost instantaneously to all limbs. The dyskinesias were dystonic and ballistic at the start, and became increasingly choreic as they attained the upper limbs. Their intensity was maximal in the lower limbs, then progressively decreased, while increasing in upper limbs and head. The results indicate that there is no strict dichotomy between biphasic and monophasic dyskinesias. In other words, there is a "continuum" between the first dyskinesias and those observed during the period of maximal clinical improvement. These dyskinesias can also appear in reverse order, as if there were an "oscillator" determining a sequence of alternating patterns.
BNP‐induced activation of cGMP in human cardiac fibroblasts: Interactions with fibronectin and natriuretic peptide receptors (2006)

Cardiac remodeling involves the accumulation of extracellular matrix (ECM) proteins including fibronectin (FN). FN contains RGD motifs that bind integrins at DDX sequences allowing signaling from the ECM to the nucleus. We noted that the natriuretic peptide receptor A (NPR-A) sequence contains both RGD and DDX sequences. The goal of the current investigation was to determine potential interactions between FN and NPR-A on BNP induction of cGMP in cultured human cardiac fibroblasts (CFs). Further, we sought to determine whether a Mayo designed NPR-A specific RGD peptide could modify this interaction. Here we reconfirm the presence of all three natriuretic peptide receptors (NPR) in CFs. CFs plated on FN demonstrated a pronounced increase in cGMP production to BNP compared to non-coated plates. This production was also enhanced by the NPR-A specific RGD peptide, which further augmented FN associated cGMP production. Addition of HS-142-1, a NPR-A/B antagonist, abrogated the responses of BNP to both FN and the NPR-A specific RGD peptide. Finally, we defined a possible role for the NPR-C through non-cGMP mechanisms in mediating the anti-proliferative actions of BNP in CFs where the NPR-C antagonist cANF 4-28 but not HS-142-1 blocked BNP-mediated inhibition of proliferation of CFs. We conclude that NPR-A interacts with components of the ECM such as FN to enhance BNP activation of cGMP and that a small NPR-A specific RGD peptide augments this action of BNP with possible therapeutic implications. Lastly, the NPR-C may also have a role in mediating anti-proliferative actions of BNP in CFs.
3D tomographic reconstruction of coronary arteries using a precomputed 4D motion field (2004)

International audience
Performance limitations of the Java core libraries (1999)

Article Performance limitations of the Java core libraries Share on Authors: Allan Heydon Compaq Computer Corporation, Systems Research Center, 130 Lytton Avenue, Palo Alto, CA Compaq Computer Corporation, Systems Research Center, 130 Lytton Avenue, Palo Alto, CAView Profile , Marc Najork Compaq Computer Corporation, Systems Research Center, 130 Lytton Avenue, Palo Alto, CA Compaq Computer Corporation, Systems Research Center, 130 Lytton Avenue, Palo Alto, CAView Profile Authors Info & Claims JAVA '99: Proceedings of the ACM 1999 conference on Java GrandeJune 1999 Pages 35–41https://doi.org/10.1145/304065.304092Online:01 June 1999Publication History 18citation508DownloadsMetricsTotal Citations18Total Downloads508Last 12 Months3Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Spinal Muscular Atrophy: Clinical Classification and Disease Heterogeneity (2007)

The clinical classification of spinal muscular atrophy, caused by deletion of the survival motor neuron 1 gene (SMN1), is based on age at onset and maximum function achieved. Evidence suggests that maximum function achieved is more closely related to life expectancy than age at onset. Therefore, it is important to wait for a period before assigning a patient to 1 of 5 classes of the disorder. Several diseases result from degeneration of the anterior horn cell but are not caused by SMN1. The classification for these conditions is evolving. This article offers an attempt at organizing one's thinking about this disease group.
ITU-T G.EV-VBR baseline codec (2008)

We present the G.EV-VBR winning candidate codec recently selected by Question 9 of Study Group 16 (Q9/16) of ITU-T as a baseline for the development of a scalable solution for wideband speech and audio compression at rates between 8 kb/s and 32 kb/s. The Q9/16 codec is an embedded codec comprising 5 layers where higher layer bitstreams can be discarded without affecting the decoding of the lower layers. The two lower layers are based on the CELP technology where the core layer takes advantage of signal classification based encoding. The higher layers encode the weighted error signal from lower layers using overlap-add transform coding. The codec has been designed with the primary objective of a high-performance wideband speech coding for error-prone telecommunications channels, without compromising the quality for narrowband/wideband speech or wideband music signals. The codec performance is demonstrated with selected test results.
Synthesis of New 3-(Pyridylmethylene)-, 3-(Pyridylmethyl)-, 3-(Piperidylmethyl)-, and 3-(β-Alkylaminoethyl)-2-indolinones. The Reduction of Isoindogenides, Nitro Compounds, and Pyridines in a Series of 2-Indolinones (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of New 3-(Pyridylmethylene)-, 3-(Pyridylmethyl)-, 3-(Piperidylmethyl)-, and 3-(β-Alkylaminoethyl)-2-indolinones. The Reduction of Isoindogenides, Nitro Compounds, and Pyridines in a Series of 2-IndolinonesGordon N. Walker, Ronald T. Smith, and Barbara N. WeaverCite this: J. Med. Chem. 1965, 8, 5, 626–637Publication Date (Print):September 1, 1965Publication History Published online1 May 2002Published inissue 1 September 1965https://pubs.acs.org/doi/10.1021/jm00329a016https://doi.org/10.1021/jm00329a016research-articleACS PublicationsRequest reuse permissionsArticle Views480Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Milburn cannot afford to fail us (2002)

The government’s need to deliver the NHS Plan puts nurses in a strong position, argues Maura Buchanan
Precision Stroboscopy, Voice Quality and Electrolaryngography 1 (2000)

•• • precision stroboscopy, the analysis of connected speech, and in regard to their auditory relevance. 2. Background The term “Electroglottograph” – or EGG for short, has become a generic name for a simple electrical method for the non-invasive examination of vocal fold phonatory vibration. The apposition of two electrodes on the alae of the thyroid cartilage provides a circuit element which can be monitored either in terms of its impedance or in regard to its admittance. The technique was first applied to voice work by Fabre (1957) and he used a constant current, impedance based, method of observation. He also introduced the term “electroglottographie” considering that the main information derived from the device was in respect of the glottal opening. In fact, however, the main information concerns vocal fold contact, and it was for this reason, early on, that the term “Laryngograph” was used (Lx is used here as an abbreviation for the resulting signal, now derived via a constant voltage, admittance based, method). The practical importance of vocal fold contact has since been established in several ways. Direct synchronised cinematic/Lx observation of vocal fold movement with different voice qualities (for example: Lecluse (1977); Donovan, Roach and Fourcin (in Fourcin, 1974)), made it feasible reliably to infer the contribution to Lx waveforms made by contact between the opposing faces of the vocal folds. Human experiments in vivo by the interposition of a non-conducting strip within the glottis (Gilbert, Potter & Hoodin (1984)) radically established the overriding importance of contact between the folds to the Lx waveform. (Earlier work, based on electrical admittance measurements, had shown that up to 4.5MHz resistance was potentially the more important electrical contributor to the Lx waveshape than capacitance, Fourcin & Norgate (1965)). Cadaver experiments have confirmed and extended these results. For instance using an excised single canine vocal fold dynamically abutting a conducting viewing plate (Scherer, Druker & Titze, 1988) the correspondence between conductance and contact area was shown. Using excised human cadaver larynges the nature of the contact waveform as a function of some of the physical factors influencing vibration was investigated (Laukkanen, Vilkman & Laine, 1992). Initially, essentially only the Lx signal was presented in the form of a waveform going positive (up) for increasing vocal fold contact area (this was also Fabre’s aim, but his
Percutaneous Tumor Ablation: Increased Necrosis with Combined Radio-Frequency Ablation and Intratumoral Doxorubicin Injection in a Rat Breast Tumor Model (2001)

Adjuvant intratumoral doxorubicin injection increases coagulation in solid tumors compared with RF ablation alone. Increased tumor destruction is also seen when doxorubicin is administered after RF ablation, which suggests that RF ablation may sensitize tumors to chemotherapy. Such combination therapies may, therefore, offer improved methods for ablating solid tumors.
Development of a purified cholera toxoid. III. Refinements in purification of toxin and methods for the determination of residual somatic antigen (1976)

The addition of an ultrafiltration step to the purification procedures previously described for cholera toxin (Rappaport et al., (1974) permitted the preparation of highly purified antigenic toxoids essentially free of somatic antigen(s). The purity of such toxoids is established: (i) by the absence of more than about one part limulus amebocyte lysate (LAL)-positive endotoxin per 10(5) parts toxoid and (ii) by the inability of the toxoids to elicit a significant rise in rabbit vibriocidal antibody. The antigenicity of the toxoids is demonstrated by their ability to produce the same high levels of rabbit serum antitoxin as are produced by comparable toxoids containing small amounts of somatic antigen. The results also indicate that amounts of somatic antigen of the order of less than or equal to 1 mug/100 mug of toxoid do not exert an adjuvant effect on the toxoid, at least with respect to circulating antitoxin. Other data show that, where present, the ability of somatic antigen to elicit vibriocidal antibody is influenced by the immunization schedule employed and that a correlation exists between the LAL-determined endotoxin content of the toxoids and their ability to stimulate vibriocidal antibody. Somatic antigen-free toxoids, purified and tested by the refinements herein described, were prepared for use in the National Institutes of Health sponsored field trials, and data pertaining to their purity and antigenic properties are presented.
Comparison of hypersensitivity reactions of intravenous iron: iron isomaltoside‐1000 (Monofer®) versus ferric carboxy‐maltose (Ferinject®). A single center, cohort study (2018)

Ferric carboxymaltose is associated with a 75% lower risk for HSRs compared with iron isomaltoside-1000 in our population. The presence of a comorbidity raises the likelihood of an HSR by a factor of three regardless of the type of intravenous iron infusion. Further research is needed to clarify the underlying mechanism in various patient groups.
Optical Biosensors (2008)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical BiosensorsSergey M. Borisov and Otto S. WolfbeisView Author Information Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, D-93040 Regensburg, Germany Cite this: Chem. Rev. 2008, 108, 2, 423–461Publication Date (Web):January 30, 2008Publication History Received2 April 2007Published online30 January 2008Published inissue 1 February 2008https://pubs.acs.org/doi/10.1021/cr068105thttps://doi.org/10.1021/cr068105tresearch-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views19545Altmetric-Citations876LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Carbohydrates,Fluorescence,Peptides and proteins,Sensors Get e-Alerts