gebhart/patrepeval huggingface dataset:
Control of β1 Integrin Function (1996)

The beta1 integrins can be expressed on the surface of cells in a latent form, which is activated by a variety of stimuli. As an approach to examining the transition to an active receptor, a panel of stimulatory antibodies to beta1 were produced and characterized. These antibodies induced adherence of the T-leukemic cell line Jurkat to collagen and fibronectin. Competitive antibody binding assays indicated the existence of at least three distinct epitope clusters A (B3B11, JB1B, 21C8), B (B44, 13B9), and C(N29) defined by the indicated antibodies. Two antibodies to the A site, JB1B and B3B11, were shown to localize to positions 671-703 and 657-670, respectively, of the beta1. This region is located in an area encompassing a predicted disulfide bond between linearly distant cysteines in beta1 (Cys415-Cys671). The homologous region of the beta3 integrin (490 690 and 602 690) has been shown to be one of the sites recognized by stimulatory antibodies to ligand-induced binding sites. The present results indicate the existence of multiple stimulatory regions and suggest considerable homology between the locations of beta1 and beta3 regulatory sites.
The complexity of robot motion planning (1988)

The Complexity of Robot Motion Planning makes original contributions both to robotics and to the analysis of algorithms. In this groundbreaking monograph John Canny resolves long-standing problems concerning the complexity of motion planning and, for the central problem of finding a collision free for a jointed robot in the presence of obstacles, obtains exponential speedups over existing algorithms by applying high-powered new mathematical techniques.Canny's new algorithm for this movers' the most-studied and basic robot motion planning problem, has a single exponential running time, and is polynomial for any given robot. The algorithm has an optimal running time exponent and is based on the notion of roadmaps - one-dimensional subsets of the robot's configuration space. In deriving the single exponential bound, Canny introduces and reveals the power of two tools that have not been previously used in geometric algorithms: the generalized (multivariable) resultant for a system of polynomials and Whitney's notion of stratified sets. He has also developed a novel representation of object orientation based on unnormalized quaternions which reduces the complexity of the algorithms and enhances their practical applicability.After dealing with the movers' problem, the book next attacks and derives several lower bounds on extensions of the problem: finding the shortest among polyhedral obstacles, planning with velocity limits, and compliant motion planning with uncertainty. It introduces a clever technique, path encoding, that allows a proof of NP-hardness for the first two problems and then shows that the general form of compliant motion planning, a problem that is the focus of a great deal of recent work in robotics, is non-deterministic exponential time hard. Canny proves this result using a highly original construction.John Canny received his doctorate from MIT And is an assistant professor in the Computer Science Division at the University of California, Berkeley. The Complexity of Robot Motion Planning is the winner of the 1987 ACM Doctoral Dissertation Award.
Nanowire Heterostructures Comprising Germanium Stems and Silicon Branches as High-Capacity Li-Ion Anodes with Tunable Rate Capability (2015)

Here we report the rational design of a high-capacity Li-ion anode material comprising Ge nanowires with Si branches. The unique structure provides an electrode material with tunable properties, allowing the performance to be tailored for either high capacity or high rate capability by controlling the mass ratio of Si to Ge. The binder free Si-Ge branched nanowire heterostructures are grown directly from the current collector and exhibit high capacities of up to ∼1800 mAh/g. Rate capability testing revealed that increasing the Ge content within the material boosted the performance of the anode at fast cycling rates, whereas a higher Si content was optimal at slower rates of charge and discharge. Using ex-situ electron microscopy, Raman spectroscopy and energy dispersive X-ray spectroscopy mapping, the composition of the material is shown to be transient in nature, transforming from a heterostructure to a Si-Ge alloy as a consequence of repeated lithiation and delithiation.
Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits (1994)

The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta, and IL-2R gamma chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9. Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3. Jak1 and Jak3 were found to be selectively associated with the "serine-rich" region of IL-2R beta and the carboxyl-terminal region of IL-2R gamma, respectively. Both regions were necessary for IL-2 signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling.
First-in-Man Phase I Study of GC33, a Novel Recombinant Humanized Antibody Against Glypican-3, in Patients with Advanced Hepatocellular Carcinoma (2013)

This study shows that GC33 was well tolerated in advanced HCC and provides preliminary evidence that GPC3 expression in HCC may be associated with the clinical benefit to GC33 that warrants prospective evaluation.
The molecular mechanism of ethylene signal transduction (2006)

Ethylene (ET) is a signaling molecule that coordinates responses to a multitude of biotic and abiotic stresses in plants. This is a review of recent advances in our understanding of the regulation of ET biosynthesis, perception, signal transduction, and the cross-talk between the transduction pathways of ET and other signaling molecules such as jasmonates, salicylic acid and abscisic acid in plant defense against biotic and abiotic stresses.
High-Density Labeling of DNA: Preparation and Characterization of the Target Material for Single-Molecule Sequencing (2001)

Encouraged by the international race to sequence the human genome, new approaches to decode single copies of DNA have emerged. These could potentially speed up the sequencing process—if all bases in DNA could be tagged with distinct fluorescent labels. Complete labeling of the pyrimidine bases of one strand, as described here, might be a first solution to this problem.
Molecular Weight Control by a "Living" Free-Radical Polymerization Process (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Weight Control by a "Living" Free-Radical Polymerization ProcessCraig J. HawkerCite this: J. Am. Chem. Soc. 1994, 116, 24, 11185–11186Publication Date (Print):November 1, 1994Publication History Published online1 May 2002Published inissue 1 November 1994https://pubs.acs.org/doi/10.1021/ja00103a055https://doi.org/10.1021/ja00103a055research-articleACS PublicationsRequest reuse permissionsArticle Views4586Altmetric-Citations556LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A 23 &#x00B5;A RF-powered transmitter for biomedical applications (2011)

We propose a new tag architecture that employs an active transmitter to decouple the frequencies used for power and data telemetry. Receiving power at 918 MHz and transmitting data at 306 MHz eliminates the “self-jamming” problem presented to RFID readers, reducing the complexity of reader design. This scheme allows remote placement of the data receiver and extends the data transmission range. Our transmitter uses subharmonic injection-locking to avoid power hungry LO generation circuitry while eliminating the need for quartz crystals. The tag prototype was fabricated using a 0.13 μm CMOS process, occupying 0.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> active area. With an on-off keying (OOK) data rate of 4 Mbps, the 23 μA transmitter with an output power of -33 dBm achieves an energy efficiency of 10 pJ/bit, the best reported to date for such systems.
Development of the lymphatic vascular system: A mystery unravels (2004)

The blood vascular and the lymphatic system play complementary roles in tissue perfusion and fluid reabsorption. Despite its critical role in mediating tissue fluid homeostasis, intestinal lipid absorption, and the immune response, the lymphatic system has not received as much attention as the blood vascular system, largely due to a lack of lymphatic-specific markers and to the dearth of knowledge about the molecular regulation of lymphatic development and function. A series of recent landmark studies now significantly has advanced our understanding of the lymphatic system. Based upon the discovery and characterization of lymphatic-specific growth factors, receptors, and transcriptional regulators, the mystery of lymphatic vascular system development begins to be unraveled. The successful isolation and cultivation of blood vascular and lymphatic endothelial cells has enabled comparative molecular and cellular analyses of these two genetically and developmentally closely related cell lineages. Moreover, studies of several genetic mouse models have set the framework for a new molecular model of embryonic lymphatic vascular development and have identified molecular pathways whose mutational inactivation leads to human diseases associated with lymphedema. Although these rapid advances already have led to development of the first lymphatic-targeted molecular therapies, there still remain many unanswered questions regarding almost every aspect of lymphatic vascular biology, making the lymphatic system a highly exciting and rewarding field of study.
Regional Alterations in Protein Expression in the Dyssynchronous Failing Heart (2003)

LV dyssynchrony in failing hearts generates myocardial protein dysregulation concentrated in the late-activated, high-stress lateral endocardium. Such molecular polarization within the LV creates transmural and transchamber expression gradients of calcium handling and gap junction proteins that may worsen chamber function and arrhythmia susceptibility.
Optimization Analysis Based on a Breadth-First Exploration for a Structural Approach of Sketches Interpretation (2012)

In this paper, we present an optimized approach, based on a competitive breadth-first exploration of the analysis tree, for an interactive interpretation of off-line sketch. The competitive breadth-first exploration of the analysis tree, allows to compare several hypotheses of interpretation to deal with confusion. Unfortunately, in practice these methods are rarely used because they often induce a large combinatory. This paper presents an optimization strategy to minimize the combinatory. The aim is to demonstrate the relevance of a competitive breadth-first exploration in off-line document analysis, in particular when the approach is interactive, ie the user is involved into the loop analysis. This paper demonstrates this optimized interactive analysis method on off-line handwritten 2D architectural floor plans.
CONCEPT FORMATION: 'OBJECT' ATTRIBUTES DYNAMICALLY INHIBITED FROM CONSCIOUS AWARENESS (2004)

We advance a dominant neural strategy for facilitating conceptual thought. Concepts are groupings of "object" attributes. Once the brain learns such critical groupings, the "object" attributes are inhibited from conscious awareness. We see the whole, not the parts. The details are inhibited when the concept network is activated, ie. the inhibition is dynamic and can be switched on and off. Autism is suggested to be the state of retarded concept formation. Our model predicts the possibility of accessing nonconscious information by artificially disinhibiting (turning off) the inhibiting networks associated with concept formation, using transcranial magnetic brain stimulation (TMS). For example, this opens the door for the restoration of perfect pitch, for recalling detail, for acquiring accent-free second languages beyond puberty, and even for enhancing creativity. The model further shows how unusual autistic savant skills as well as certain psychopathologies can be due respectively to privileged or inadvertent access to information that is normally inhibited from conscious awareness.
Mixed solvent systems for recovery of ethanol from dilute aqueous solution by liquid–liquid extraction (1987)

Distribution coefficients and selectivities of a number of mixed solvent systems have been determined in order to assess their suitability in preferentially extracting ethanol from aqueous solution. The measured values of distribution coefficients and selectivities differ substantially from the values estimated by interpolating between the pure solvents.
Mysteries of TOPSe Revealed: Insights into Quantum Dot Nucleation (2010)

We have investigated the reaction mechanism responsible for QD nucleation using optical absorption and nuclear magnetic resonance spectroscopies. For typical II-VI and IV-VI quantum dot (QD) syntheses, pure tertiary phosphine selenide sources (e.g., trioctylphosphine selenide (TOPSe)) were surprisingly found to be unreactive with metal carboxylates and incapable of yielding QDs. Rather, small quantities of secondary phosphines, which are impurities in tertiary phosphines, are entirely responsible for the nucleation of QDs; their low concentrations account for poor synthetic conversion yields. QD yields increase to nearly quantitative levels when replacing TOPSe with a stoiciometric amount of a secondary phosphine chalcogenide such as diphenylphosphine selenide. Based on our observations, we have proposed potential monomer identities, reaction pathways, and transition states and believe this mechanism to be universal to all II-VI and IV-VI QDs synthesized using phosphine based methods.
Electronic WDM crosstalk cancellation (2002)

We report the electronic cancellation of WDM demux crosstalk at 10 Gb/s. We demonstrate a power penalty reduction of up to 2 dB for an optically amplified system, and 1 dB for a thermal noise limited system. We also analyse and quantify the limits of such a technique in a real system.
PKI and Revocation Survey (2000)

This survey covers basic information about public key infrastructures and summarizes the predominant technology and standards. Special attention is given to mechanisms for certificate revocation. Methods for CRL distribution and validity checking are compared. 1 Supported by KDD R&amp;amp;D Laboratories, Inc.
Surfactant-like Properties of an Amphiphilic α-Helical Peptide Leading to Lipid Nanodisc Formation (2014)

Nanodiscs are self-assembled discoidal nanoparticles composed of amphiphilic α-helical scaffold proteins or peptides that wrap themselves around the circumference of a lipid bilayer in a beltlike manner. In this study, an amphiphilic helical peptide that mimics helix 10 of human apoA-I was newly synthesized by solid phase peptide synthesis using Fmoc chemistry, and its physicochemical properties, including surface tension, self-association, and solubilization abilities, were evaluated and related directly to nanodisc formation. The synthesized peptide having hydrophobic and hydrophilic faces behaves like a general surfactant, affording a critical association concentration (CAC) of 2.7 × 10(-5) M and a γCAC of 51.2 mN m(-1) in aqueous solution. Interestingly, only a peptide solution above its CAC was able to microsolubilize L-α-dimyristoylphosphatidylcholine (DMPC) vesicles, and lipid nanodiscs with an average diameter of 9.5 ± 2.7 nm were observed by dynamic light scattering and negative stain transmission electron microscopy. Moreover, the ζ potentials of the lipid nanodiscs were measured for the first time as a function of pH, and the values changed from positive (20 mV) to negative (-30 mV). In particular, nanodisc solutions at acidic pH 4 (20 mV) or basic pH 9 (-20 mV) were found to be stable for more than 6 months as a result of the electrostatic repulsion between the particles.
A Self-Assembled Supramolecular Optical Sensor for Ni(II), Cd(II), and Cr(III) (2004)

A new chromogenic supramolecular sensor for transition metals is reported. It is based on a newly designed phenanthroline-containing molecule that self-assembles via an organometallic "clip" into a supramolecular optical sensor for metals. [reaction: see text]
Highly Efficient Extraction of Sulfate Ions with a Tripodal Hexaurea Receptor (2010)

Fatal extraction: The Hofmeister bias for sulfate ions in aqueous environments can be overcome by using a tripodal hexaurea receptor (L) that completely encapsulates the sulfate ion in a complementary cavity protected by hydrophobic aromatic rings (see picture; C gray, N blue, O red, S yellow). Almost quantitative extraction of sulfate ions from an aqueous to an organic phase is achieved when this receptor is used as a liquid–liquid extractant.
Clomipramine in the treatment of premature ejaculation (1988)

(1988). Clomipramine in the treatment of premature ejaculation. The Journal of Sex Research: Vol. 24, No. 1, pp. 213-215.
Anti-inflammatory Cytokine Profile in Human Heart Failure (1999)

Proinflammatory cytokines, i.e., tumor necrosis factor-alpha (TNFalpha), participate in the development and the progression of congestive heart failure (CHF). On the other hand, an anti-inflammatory cytokine may neutralize the proinflammatory cytokines of CHF. Interleukin-10 (IL-10) is known to suppress the synthesis of proinflammatory cytokines. IL-10 and the IL-10 receptor system was investigated in comparison with the behavior of TNFalpha in 68 patients with various causes of CHF (mean age: 61 years) and in 31 normal subjects (61 years). The circulating IL-10 level was higher in CHF patients than in normal subjects (p<0.05). The TNFalpha level was higher in CHF patients than in control subjects (p<0.005). The ratio of IL-10 to TNFalpha tended to be higher in control subjects than in patients with CHF (p = 0.09). With lipopolysaccharide treatment, the release of IL-10 was more enhanced from mononuclear leukocyte of patients with CHF than from control subjects (p<0.05). The expression of the IL-10 receptor estimated by flow cytometry of mononuclear leukocytes was higher in the CHF patients than in the normal subjects. The IL-10/IL-10 receptor system was activated, at least partly, to downregulate an excess of TNFalpha in patients with advanced CHF. IL-10 may be an important inherent component of the cytokine network of CHF.
Stereoelectronic effects in the reactions of epimeric 2-aryloxy-2-oxy-1,3,2-dioxaphosphorinanes and oxazaphosphorinanes (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoelectronic effects in the reactions of epimeric 2-aryloxy-2-oxy-1,3,2-dioxaphosphorinanes and oxazaphosphorinanesDavid G. Gorenstein, Robert Rowell, and John FindlayCite this: J. Am. Chem. Soc. 1980, 102, 15, 5077–5081Publication Date (Print):July 1, 1980Publication History Published online1 May 2002Published inissue 1 July 1980https://pubs.acs.org/doi/10.1021/ja00535a044https://doi.org/10.1021/ja00535a044research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance (2017)

Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)<sub>2A</sub> subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological variability between individuals that can influence dose-response and toxicological profile has been reported. This review aims to discuss metabolism of psilocybin and psilocin, by presenting all major and minor psychoactive metabolites. Psilocybin is primarily a pro-drug that is dephosphorylated by alkaline phosphatase to active metabolite psilocin. This last is then further metabolized, psilocin-O-glucuronide being the main urinary metabolite with clinical and forensic relevance in diagnosis.
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis (2011)

Nitazoxanide (Alinia(®)), a nitro-thiazolyl antiparasitic drug, kills diverse microorganisms by unknown mechanisms. Here we identified two actions of nitazoxanide against Mycobacterium tuberculosis (Mtb): disruption of Mtb's membrane potential and pH homeostasis. Both actions were shared by a structurally related anti-mycobacterial compound, niclosamide. Reactive nitrogen intermediates were reported to synergize with nitazoxanide and its deacetylated derivative tizoxanide in killing Mtb. Herein, however, we could not attribute this to increased uptake of nitazoxanide or tizoxanide as monitored by targeted metabolomics, nor to increased impact of nitazoxanide on Mtb's membrane potential or intrabacterial pH. Thus, further mechanisms of action of nitazoxanide or tizoxanide may await discovery. The multiple mechanisms of action may contribute to Mtb's ultra-low frequency of resistance against nitazoxanide.