Hepatitis C Genotypes: The Key to Pathogenicity? (1995)

Editorials1 February 1995Hepatitis C Genotypes: The Key to Pathogenicity?Paul Martin, MDPaul Martin, MDUniversity of California at Los Angeles, Los Angeles, CA 90024Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-3-199502010-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Although investigation of the hepatitis C virus (HCV) has proceeded rapidly since the virus was discovered, numerous important issues about HCV, including the risk for disease progression in patients with chronic HCV infection and the role of interferon therapy, require clarification. This discussion focuses on predictors of both disease progression and response to interferon therapy; in particular, it considers the ways in which new research on HCV genotypes may shed light on these important and unresolved questions.As it would for any chronic disease, an understanding of the natural history of HCV provides a basis for rational decisions about management ...References1. Alter HJ. Chronic consequences of non-A, non-B hepatitis. In: Seeff LB, Lewis JH, eds. Current Perspectives in Hepatology: Festschrift for Hyman J. Zimmerman, M.D. New York: Plenum Medical; 1989:83-97. Google Scholar2. Koretz RL, Abbey H, Coleman E, Gitnick G. Non-A, non-B post-transfusion hepatitis. Looking back in the second decade. Ann Intern Med. 1993; 119:110-5. Google Scholar3. Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter JH, Iber FL, et al. Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. 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Typing of hepatitis C virus isolates and characterization of new subtypes using a line probe assay. J Gen Virol. 1993; 74(Pt 6):1093-102. Google Scholar12. Simmonds P, Alberti A, Alter HJ, Bonino F, Bradley DW, Brechot C, et al. A proposed system for the nomenclature of hepatitis C viral genotypes (Letter). Hepatology. 1994; 19:1321-4. Google Scholar13. Takada N, Takase A, Takada A, Date T. Differences in the hepatitis C virus genotypes in different countries. J Hepatol. 1993; 17:277-83. Google Scholar14. Dusheiko G, Schmilovitz-Weiss H, Brown D, McOmish F, Yap PL, Sherlock S, et al. Hepatitis C virus genotypes: an investigation of type-specific differences in geographic origin and disease. Hepatology. 1994; 19:13-8. Google Scholar15. Matsumoto A, Tanaka E, Suzuki T, Ogata H, Kiyosawa K. Viral and host factors that contribute to efficacy of interferon-2a therapy in patients with chronic hepatitis C. Dig Dis Sci. 1994; 39:1273-80. Google Scholar16. Mita E, Hayashi N, Hagiwara H, Ueda K, Kanazawa Y, Kasahara A, et al. Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer. Dig Dis Sci. 1994; 39:977-82. Google Scholar17. Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C, et al. Hepatitis C virus type 1b (II) infection in France and Italy. Ann Intern Med. 1994; 122:161-8. Google Scholar18. Lau JY, Mizokami M, Ohno T, Diamond DA, Kniffen J, Davis GL, et al. Discrepancy between biochemical and virological responses to interferon-α in chronic hepatitis C. Lancet. 1993; 342:1208-9. Google Scholar19. Orito E, Mizokami M, Mizoguchi N, et al. Hepatitis C virus serotype II responds more favorably to interferon-therapy. J Hepatol. 1994; 21:130-2. Google Scholar20. Simmonds P, Rose KA, Graham S, Chan SW, McOmish F, Dow BC, et al. Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infection with HCV types 1, 2, and 3. J Clin Microbiol. 1993; 31:1493-503. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California at Los Angeles, Los Angeles, CA 90024Corresponding Author: Paul Martin, MD, Division of Digestive Diseases, Center for the Health Sciences, University of California at Los Angeles, Los Angeles, CA 90024.Acknowledgments: The author thanks Judy Grimes for excellent secretarial help and Johnson Y.N. Lau, MD, for helpful suggestions. 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