gebhart/patrepeval huggingface dataset:
Deep Neural Networks for Large Vocabulary Handwritten Text Recognition (2015)

The automatic transcription of text in handwritten documents has many applications, from automatic document processing, to indexing and document understanding. One of the most popular approaches nowadays consists in scanning the text line image with a sliding window, from which features are extracted, and modeled by Hidden Markov Models (HMMs). Associated with neural networks, such as Multi-Layer Perceptrons (MLPs) or Long Short-Term Memory Recurrent Neural Networks (LSTM-RNNs), and with a language model, these models yield good transcriptions. On the other hand, in many machine learning applications, including speech recognition and computer vision, deep neural networks consisting of several hidden layers recently produced a significant reduction of error rates. In this thesis, we have conducted a thorough study of different aspects of optical models based on deep neural networks in the hybrid neural network / HMM scheme, in order to better understand and evaluate their relative importance. First, we show that deep neural networks produce consistent and significant improvements over networks with one or two hidden layers, independently of the kind of neural network, MLP or RNN, and of input, handcrafted features or pixels. Then, we show that deep neural networks with pixel inputs compete with those using handcrafted features, and that depth plays an important role in the reduction of the performance gap between the two kinds of inputs, supporting the idea that deep neural networks effectively build hierarchical and relevant representations of their inputs, and that features are automatically learnt on the way. Despite the dominance of LSTM-RNNs in the recent literature of handwriting recognition, we show that deep MLPs achieve comparable results. Moreover, we evaluated different training criteria. With sequence-discriminative training, we report similar improvements for MLP/HMMs as those observed in speech recognition. We also show how the Connectionist Temporal Classification framework is especially suited to RNNs. Finally, the novel dropout technique to regularize neural networks was recently applied to LSTM-RNNs. We tested its effect at different positions in LSTM-RNNs, thus extending previous works, and we show that its relative position to the recurrent connections is important. We conducted the experiments on three public databases, representing two languages (English and French) and two epochs, using different kinds of neural network inputs: handcrafted features and pixels. We validated our approach by taking part to the HTRtS contest in 2014. The results of the final systems presented in this thesis, namely MLPs and RNNs, with handcrafted feature or pixel inputs, are comparable to the state-of-the-art on Rimes and IAM. Moreover, the combination of these systems outperformed all published results on the considered databases.
Sea Experiment of Positioning Underwater Mobile Vehicles Using Multiple Surface Beacons (2020)

In the paper, we present the sea experiment of positioning underwater vehicles using multiple surface beacons. A system is designed to realize the underwater vehicles' positioning using the time difference of arrivals (TDOA) technique, where no strict clock synchronization between beacons and underwater vehicles is required. Moreover, an Extended Kalman Filter (EKF) method is introduced to improve the robustness. A sea experiment is conducted to verify the proposed positioning method. In the experiment, three surface beacons broadcast positioning messages synchronously at a given interval. The underwater node uses the received positioning messages and its corresponding arrival time to perform the position calculation. The experimental results show that the proposed positioning method works well and the average positioning error is less than 20 meters.
Agrobacterium tumefaciens-mediated transformation of yeast. (1996)

Agrobacterium tumefaciens transfers a piece of its Ti plasmid DNA (transferred DNA or T-DNA) into plant cells during crown gall tumorigenesis. A. tumefaciens can transfer its T-DNA to a wide variety of hosts, including both dicotyledonous and monocotyledonous plants. We show that the host range of A. tumefaciens can be extended to include Saccharomyces cerevisiae. Additionally, we demonstrate that while T-DNA transfer into S. cerevisiae is very similar to T-DNA transfer into plants, the requirements are not entirely conserved. The Ti plasmid-encoded vir genes of A. tumefaciens that are required for T-DNA transfer into plants are also required for T-DNA transfer into S. cerevisiae, as is vir gene induction. However, mutations in the chromosomal virulence genes of A. tumefaciens involved in attachment to plant cells have no effect on the efficiency of T-DNA transfer into S. cerevisiae. We also demonstrate that transformation efficiency is improved 500-fold by the addition of yeast telomeric sequences within the T-DNA sequence.
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium (2007)

Microbial consortia form when multiple species colocalize and communally generate a function that none is capable of alone. Consortia abound in nature, and their cooperative metabolic activities influence everything from biodiversity in the global food chain to human weight gain. Here, we present an engineered consortium in which the microbial members communicate with each other and exhibit a "consensus" gene expression response. Two colocalized populations of Escherichia coli converse bidirectionally by exchanging acyl-homoserine lactone signals. The consortium generates the gene-expression response if and only if both populations are present at sufficient cell densities. Because neither population can respond without the other's signal, this consensus function can be considered a logical AND gate in which the inputs are cell populations. The microbial consensus consortium operates in diverse growth modes, including in a biofilm, where it sustains its response for several days.
Surface‐enhanced Raman scattering of xanthopterin adsorbed on colloidal silver (2001)

Abstract Surface‐enhanced Raman scattering (SERS) of xanthopterin adsorbed on colloidal silver was measured and the Raman spectrum calculated by the density functional theory method was also obtained. Xanthopterin can be detected down to 5 × 10 −9 M and the enhancement of the scattering intensity is at least 10 5 ‐fold. Xanthopterin molecules are adsorbed flatly on the surface of the Ag particles. This study shows that SERS could be another prospective method for the detection of pterines. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Reduced-complexity data acquisition system for image-based localization in indoor environments (2013)

Image-based localization has important commercial applications such as augmented reality and customer analytics. In prior work, we developed a three step pipeline for image-based localization of mobile devices in indoor environments. In the first step, we generate a 2.5D georeferenced image database using an ambulatory backpack-mounted system originally developed for 3D modeling of indoor environments. Specifically, we first create a dense 3D point cloud and polygonal model from the side laser scanner measurements of the backpack, and then use it to generate dense 2.5D database image depthmaps by raytracing the 3D model. In the second step, a query image is matched against the image database to retrieve the best-matching database image. In the final step, the pose of the query image is recovered with respect to the best-matching image. Since the pose recovery in step three only requires sparse depth information at certain SIFT feature keypoints in the database image, in this paper we improve upon our previous method by only calculating depth values at these keypoints, thereby reducing the required number of sensors in our data acquisition system. To do so, we use a modified version of the classic multi-camera 3D scene reconstruction algorithm, thereby eliminating the need for expensive geometry laser range scanners. Our experimental results in a shopping mall indicate that the proposed reduced complexity sparse depthmap approach is nearly as accurate as our previous dense depth map method.
Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. (2004)

This study showed a histomorphometric increase in bone formation with the addition of PRP to Bio-Oss in non-critical-sized defects in the rabbit cranium.
Derivatization with monomethoxypolyethylene glycol of Igs expressing viral epitopes obviates adjuvant requirements. (1995)

Ig molecules expressing within the CDR3 loop viral B or T cell epitopes were derivatized with mPEG 5,000. Pegylated Ig were used to investigate the in vitro and in vivo effect of pegylation on the immunogenicity of viral epitopes expressed in chimeric Ig. Two chimeras were used in this study: Ig-HA carrying a CD4 epitope corresponding to amino acid residues 110-120 of the hemagglutinin (HA) of PR8 influenza A virus and Ig-V3C, a murine-human chimera carrying a consensus B cell epitope from the V3 loop of HIV-1 gp120 protein. Pegylated Ig-HA (Ig-HA-mPEG) with 6 to 8% substituted lysine residues showed in vivo resistance to enzymatic degradation and persisted significantly in blood circulation and lymphoid organs. Moreover, Ig-HA-mPEG was able to activate in vitro HA110-120-specific hybridoma T cells and to prime T cell proliferative response in vivo without requirement for adjuvant. Also, mildly pegylated Ig-V3C (Ig-V3C-mPEG) administered into BALB/c mice in the absence of adjuvant induced specific Ab response to V3C peptide with insignificant response to xenogeneic human Ig determinants.
Simultaneous onset of Type 1 diabetes mellitus in identical infant twins with enterovirus infection (1998)

This report describes classical Type 1 insulin deficient diabetes mellitus (DM) arising in twins aged 14 months, both of whom had evidence of enterovirus infection. The diagnosis of Type 1 DM was made in the second twin within 12 days of the first. Enterovirus infection was detected in each twin at diagnosis by polymerase chain reaction (PCR). Both twins were negative for enterovirus by PCR 5 months following diagnosis, although both were then positive for islet cell antibodies. Sequencing of the amplicons produced by PCR suggested that the viruses from each twin were not the same but that they were both variants related to echovirus 6.
Long-Term Complications of Diabetes Mellitus (1993)

Diabetes mellitus is a disease of metabolic dysregulation, most notably abnormal glucose metabolism, accompanied by characteristic long-term complications. The complications that are specific to diabetes include retinopathy, nephropathy, and neuropathy. Patients with all forms of diabetes of sufficient duration, including insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus (NIDDM), are vulnerable to these complications, which cause serious morbidity (Table 1 and Table 2). Retinopathy is so characteristic of diabetes that its presence has been incorporated into the nosologic definition of NIDDM. Only hyperglycemia of sufficient magnitude to be associated with retinopathy is classified as NIDDM, while lower levels of hyperglycemia that are . . .
Reducing dynamic energy of set-associative L1 instruction cache by early tag lookup (2015)

To minimize the access latency of set-associative caches, the data in all ways are read out in parallel with the tag lookup. However, this is energy inefficient, as only the data from the matching way is used and the others are discarded. This paper proposes an early tag lookup (ETL) technique for L1 instruction caches that determines the matching way one cycle earlier than the cache access, so that only the matching data way need be accessed. ETL incurs no performance penalty and insignificant hardware overhead. Evaluation on a 4-way set-associative L1 instruction cache in 45nm technology shows that ETL reduces the read energy by 68% on average.
Preparation of Methyl Lactate. (1945)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of Methyl Lactate.E. M. Filachione, J. H. Lengel, and C. H. FisherCite this: Ind. Eng. Chem. 1945, 37, 4, 388–390Publication Date (Print):April 1, 1945Publication History Published online1 May 2002Published inissue 1 April 1945https://pubs.acs.org/doi/10.1021/ie50424a024https://doi.org/10.1021/ie50424a024research-articleACS PublicationsRequest reuse permissionsArticle Views666Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Viral Culture and p24 Antigenemia of Human Immunodeficiency Virus (HIV)-Infected Individuals Correlated with Antibody Profiles Determined with Recombinant Polypeptides of All HIV-1 Open-Reading Frames (1992)

The association between viral activity and antibody profiles was investigated in 202 individuals infected by the human immunodeficiency virus (HIV) grouped according to their Walter Reed clinical stage. Each study group was subdivided into subjects positive or negative for markers of active viral replication: presence of serum p24 antigen and viral culture. In Western blots using recombinant antigens, sera of HIV-positive individuals with positive viral markers had a significantly lower antibody reactivity to several viral proteins than did individuals without viral markers. Noticeably, proteins of the gag (p24, p17) and env (gp120, COOH-terminal part of gp41) open-reading frames revealed a decreased reactivity. The antibody response to the regulatory proteins revealed no or poor association with viral activity in the host. The results suggest that seroreactivity is mainly influenced by factors reflecting the viral activity of an HIV-infected individual, while the clinical stage of the patient is less important. Especially, reductions in antibodies against gp120 and p17 were useful markers associated with increased viral activity.
Redox Control of Exofacial Protein Thiols/Disulfides by Protein Disulfide Isomerase (1999)

Protein disulfide isomerase (PDI) facilitates proper folding and disulfide bonding of nascent proteins in the endoplasmic reticulum and is secreted by cells and associates with the cell surface. We examined the consequence of over- or underexpression of PDI in HT1080 fibrosarcoma cells for the redox state of cell-surface protein thiols/disulfides. Overexpression of PDI resulted in 3.6-4. 2-fold enhanced secretion of PDI and 1.5-1.7-fold increase in surface-bound PDI. Antisense-mediated underexpression of PDI caused 38-53% decreased secretion and 10-33% decrease in surface-bound PDI. Using 5,5'-dithio-bis(2-nitrobenzoic acid) to measure surface protein thiols, a 41-50% increase in surface thiols was observed in PDI-overexpressing cells, whereas a 29-33% decrease was observed in underexpressing cells. Surface thiol content was strongly correlated with cellular (r = 0.998) and secreted (r = 0.969) PDI levels. The pattern of exofacial protein thiols was examined by labeling with the membrane-impermeable thiol reactive compound, 3-(N-maleimidylpropionyl)biocytin. Fourteen identifiable proteins on HT1080 cells were labeled with 3-(N-maleimidylpropionyl)biocytin. The intensity of labeling of 11 proteins was increased with overexpression of PDI, whereas the intensity of labeling of 3 of the 11 proteins was clearly decreased with underexpression of PDI. These findings indicated that secreted PDI was controlling the redox state of existing exofacial protein thiols or reactive disulfide bonds.
Parallel implementations of word alignment tool (2008)

Training word alignment models on large corpora is a very time-consuming processes. This paper describes two parallel implementations of GIZA++ that accelerate this word alignment process. One of the implementations runs on computer clusters, the other runs on multi-processor system using multi-threading technology. Results show a near-linear speed-up according to the number of CPUs used, and alignment quality is preserved.
High‐throughput screening and characterization of clones selected from phage display libraries (2007)

This approach is flexible, supporting primary and secondary screening for a range of functional assays, and scalable, potentially supporting the screening of thousands to hundreds of thousands of clones per hour.
Benefits of Oral Supplementation With and Without Synbiotics in Young Children With Acute Bacterial Infections (2004)

Acutely ill children (n = 129) aged 1-6 years receiving antibiotic therapy were randomized to receive a nutritional supplement with (PS) or without (P) synbiotics or a fruit-flavored drink (D) with their medications. Group PS had significantly greater weight gains (versus D) following antibiotic therapy. The percentages of subjects without bacterial illnesses 14 days following antibiotic therapy were as follows: 94.3% (PS), 87.8% (D), and 80.6% (P). PS (vs D) significantly increased fecal Lactobacillus in a subset of subjects. Oral supplements increase energy intake and promote weight gain in acutely ill children receiving antibiotics; synbiotics may confer additional benefits by increasing bifidobacteria levels.
The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor (2001)

Proteolytic maturation of proBMP-4 is required to generate an active signaling molecule. We show that proBMP-4 is cleaved by furin in a sequential manner. Cleavage at a consensus furin site adjacent to the mature ligand domain allows for subsequent cleavage at an upstream nonconsensus furin site within the prodomain. BMP-4 synthesized from precursor in which the upstream site is noncleavable is less active, signals at a shorter range, and accumulates at lower levels than does BMP-4 cleaved from native precursor. Conversely, BMP-4 cleaved from precursor in which both sites are rapidly cleaved is more active and signals over a greater range. Differential use of the upstream cleavage site could provide for tissue-specific regulation of BMP-4 activity and signaling range.
Synthetic human antibodies and a strategy for protein engineering (1998)

Our understanding of the way antibodies are built in vivo has provided an approach for engineering synthetic human antibodies in bacteria. Such antibodies have not only been raised against foreign antigens, but also against highly conserved antigens or human self-antigens, and have considerable practical potential as reagents for research and also as therapeutics. The approach also has implications for the design of antibody repertoires and for engineering other proteins with desirable binding properties. This review takes a personal view.
Network design consideration for distributed control systems (2002)

This paper discusses the impact of network architecture on control performance in a class of distributed control systems called networked control systems (NCSs) and provides design considerations related to control quality of performance as well as network quality of service. The integrated network-control system changes the characteristics of time delays between application devices. This study first identifies several key components of the time delay through an analysis of network protocols and control dynamics. The analysis of network and control parameters is used to determine an acceptable working range of sampling periods in an NCS. A network-control simulator and an experimental networked a machine tool have been developed to help validate and demonstrate the performance analysis results and identify the special performance characteristics in an NCS. These performance characteristics are useful guidelines for choosing the network and control parameters when designing an NCS.
The NS1 Protein of Human Respiratory Syncytial Virus Is a Potent Inhibitor of Minigenome Transcription and RNA Replication (1998)

The NS1 protein (139 amino acids) is one of the two nonstructural proteins of human respiratory syncytial virus (RSV) and is encoded by a very abundant mRNA transcribed from the promoter-proximal RSV gene. The function of NS1 was unknown and was investigated here by using a reconstituted transcription and RNA replication system that involves a minireplicon and viral proteins (N, P, L and M2-1) expressed from separate cotransfected plasmids. Coexpression of the NS1 cDNA strongly inhibited transcription and RNA replication mediated by the RSV polymerase, even when the level of expressed NS1 protein was substantially below that observed in RSV-infected cells. The effect depended on synthesis of NS1 protein rather than NS1 RNA alone. Transcription and both steps of RNA replication, namely, synthesis of the antigenome and the genome, appeared to be equally sensitive to inhibition. The efficiency of encapsidation of the plasmid-derived minigenome was not altered by coexpression of NS1, indicating that the inhibition occurs at a later step. In two different dicistronic minigenomes, transcription of each gene was equally sensitive to inhibition by NS1. This suggested that the gradient of transcriptional polarity was unaffected and that the effect of NS1 instead probably involves an early event such as polymerase entry on the genome. NS1-mediated inhibition of transcription and RNA replication was not affected by coexpression of the M2 mRNA, which has two open reading frames encoding the transcriptional elongation factor M2-1 and the putative negative regulatory factor M2-2. The potent nature of the NS1-mediated inhibition suggests that negative regulation is an authentic function of the NS1 protein, albeit not necessarily the only one.
Converting users to testers: an alternative approach to load test script creation, parameterization and data corellation (2012)

This paper proposes an architecture to significantly reduce the time, money and obscurity around Testing, aka Performance Testing, aka Automated Load Oracle E-Business Suite and potentially other Java based Client/Server applications. The focus of this proposal is to identify, debate and recommend alternative methods for script recording and data correlation for purposes of load testing an Oracle E-Business Suite application instance. Alternatives are needed due to the cost and effectiveness of performing load tests. The goal for this architecture proposal is to eliminate 90% of the overhead around script identification, development and data bank design/creation. Oracle Application Testing Suite and Oracle E-Business Suite are used as the basis for this paper's testing and theoretical implementations.