gebhart/patrepeval huggingface dataset:
Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment (2010)

Acute lung injury (ALI) remains a significant source of morbidity and mortality in the critically ill patient population. Defined by a constellation of clinical criteria (acute onset of bilateral pulmonary infiltrates with hypoxemia without evidence of hydrostatic pulmonary edema), ALI has a high incidence (200,000 per year in the US) and overall mortality remains high. Pathogenesis of ALI is explained by injury to both the vascular endothelium and alveolar epithelium. Recent advances in the understanding of pathophysiology have identified several biologic markers that are associated with worse clinical outcomes. Phase III clinical trials by the NHLBI ARDS Network have resulted in improvement in survival and a reduction in the duration of mechanical ventilation with a lung-protective ventilation strategy and fluid conservative protocol. Potential areas of future treatments include nutritional strategies, statin therapy, and mesenchymal stem cells.
Ring contraction of 1,2,4-benzoxadiazines to benzoxazoles (1975)

1,2,4-Benzoxadiazines (1) are converted into the corresponding benzoxazoles (2) in good yields by heating in solvents at 80–140 °C; a mechanism involving π4a+π2a cyclisation of an ortho-quinoneimine intermediate is suggested.
Treating bugs as allergies: a safe method for surviving software failures (2005)

Many applications demand availability. Unfortunately, software failures greatly reduce system availability. Previous approaches for surviving software failures suffer from several limitations, including requiring application restructuring, failing to address deterministic software bugs, unsafely speculating on program execution, and requiring a long recovery time.

This paper proposes an innovative, safe technique, called Rx, that can quickly recover programs from many types of common software bugs, both deterministic and non-deterministic. Our idea, inspired by allergy treatment in real life, is to rollback the program to a recent checkpoint upon a software failure, and then to reexecute the program in a modified environment. We base this idea on the observation that many bugs are correlated with the execution environment, and therefore can be avoided by removing the allergen from the environment. Rx requires few to no modifications to applications and provides programmers with additional feedback for bug diagnosis.
Inertial Drives for Micro- and Nanorobots: Two Novel Mechanisms (1995)

In micro or nanorobotics, high precision movement in two or more degrees of freedom is one of the main problems. Firstly, the positional precision has to be increased (&amp;lt; 10 nm) as the object sizes decrease. On the other hand, the workspace has to have macroscopic dimensions (1 cm3) to give high manoeuvrability to the system and to allow suitable handling at the micro/macroworld interface. As basic driving mechanisms for the ETHZ Nanorobot Project, two new piezoelectric devices have been developed. &amp;amp;quot;Abalone &amp;amp;quot; is a 3-dof system that relies on the impact drive principle. The 38 mm x 33 mm x 9 mm slider can be moved to each position and orientation in a horizontal plane within a theoretically infinite workspace. In the stepping mode it achieves a speed of 1 mm/s in translation and 7 deg/s in rotation. Within the actuator&amp;apos;s local range of 6 mm fine positioning is possible with a resolution better than 10 nm. &amp;amp;quot;NanoCrab &amp;amp;quot; is a bearingless rotational micromotor relying on the stick-slip effect. This 10 mm x 7 mm x 7 mm motor has the advantage of a relatively high torque at low rotational speed and an excellent runout. While the maximum velocity is 60 rpm, it reaches its highest torque of 0.3 mNm at 2 rpm. Another benefit is the powerless holding torque of 0.9 mNm. With a typical step of 0.1 mrad and a local resolution 3 orders of magnitude better than the step angle, NanoCrab can be very precisely adjusted. Design and measurements of the characteristics of these two mechanisms will be presented and compared with the theoretical analysis of inertial drives presented in a companion paper. Finally their integration into the Nanorobot system will be discussed.
Ruthenium(II) Complexes with Improved Photophysical Properties Based on Planar 4‘-(2-Pyrimidinyl)-2,2‘:6‘,2‘ ‘-terpyridine Ligands (2007)

A series of new tridentate polypyridine ligands, made of terpyridine chelating subunits connected to various substituted 2-pyrimidinyl groups, and their homoleptic and heteroleptic Ru(II) complexes have been prepared and characterized. The new metal complexes have general formulas [(R-pm-tpy)Ru(tpy)]2+ and [Ru(tpy-pm-R)2]2+ (tpy = 2,2':6',2' '-terpyridine; R-pm-tpy = 4'-(2-pyrimidinyl)-2,2':6',2' '-terpyridine with R = H, methyl, phenyl, perfluorophenyl, chloride, and cyanide). Two of the new metal complexes have also been characterized by X-ray analysis. In all the R-pm-tpy ligands, the pyrimidinyl and terpyridyl groups are coplanar, allowing an extended delocalization of acceptor orbital of the metal-to-ligand charge-transfer (MLCT) excited state. The absorption spectra, redox behavior, and luminescence properties of the new Ru(II) complexes have been investigated. In particular, the photophysical properties of these species are significantly better compared to those of [Ru(tpy)2]2+ and well comparable with those of the best emitters of Ru(II) polypyridine family containing tridentate ligands. Reasons for the improved photophysical properties lie at the same time in an enhanced MLCT-MC (MC = metal centered) energy gap and in a reduced difference between the minima of the excited and ground states potential energy surfaces. The enhanced MLCT-MC energy gap leads to diminished efficiency of the thermally activated pathway for the radiationless process, whereas the similarity in ground and excited-state geometries causes reduced Franck Condon factors for the direct radiationless decay from the MLCT state to the ground state of the new complexes in comparison with [Ru(tpy)2]2+ and similar species.
Human monocyte-mediated tumor cytotoxicity. I. Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism. (1984)

The cytolytic capacity of monocytes per se and stimulated monocytes has been documented to only a limited extent, and when observed has been ascribed to the generation of a variety of cytolytic molecular entities. In the present study we have examined de novo human monocyte-mediated tumor cytotoxicity and that induced by the agent 12-O-tetradecanoylphorbol-13-acetate (TPA). Cytolytic function was analyzed by reference to the release of [111In] oxine from two prelabeled tumor cell lines, K562 and U937, in a 16-hr assay in the presence of serum to more closely mimic in vivo circumstances. Observed cytolysis was clearly related to TPA concentration and effector cell number. Maximal cytolysis was obtained with TPA at 5 ng/ml, at which specific releases were 43% +/- 6 and 18% +/- 5 (mean +/- 1 SEM) at an effector cell to target cell (E:T) ratio of 2.5:1 and 65% +/- 6, and 41% +/- 12 at an E:T ratio of 20:1, for K562 and U937, respectively. In contrast, unstimulated monocytes expressed minimal cytolytic activity, or at best a low cytotoxic effect at high cellular ratios. When TPA-stimulated monocyte-mediated cytolysis was examined, catalase (2750 U/ml) inhibited K562 and U937 cytolysis by 92% and 84%, respectively; superoxide dismutase (300 U/ml) only inhibited cytotoxicity by 17% and 24%, respectively, implicating a central role of H2O2 rather than superoxide ions. Sodium azide (1 mM), an inhibitor of myeloperoxidase, did not diminish cytolysis; in contrast, it increased K562 and U937 cytolysis by 34% and 57%. This increased cytotoxicity was observed for K562 at low levels of cytotoxicity. These data tend to dismiss an essential role of the H2O2-halide-myeloperoxidase pathway of cytolysis. The OH scavengers, histidine (20 mM) and ethanol (40 mM), did not affect K562 killing; mannitol (50 mM), another OH scavenger, had only a slight inhibitory effect (23%). Finally, H2O2 generated by a glucose-glucose oxidase system directly mediated K562 killing and, to a lesser extent, U937 lysis. These results point strongly towards the role of: 1) a myeloperoxidase-independent mechanism of cytotoxicity, with 2) H2O2 as a key mediator of the cytolytic mechanism, and 3) a limited role of O2.- in synergy with H2O2 in the cytolytic activity of monocytes, and suggest that significant cytolytic function requires an inductive event.
High-density localization of active molecules using Structured Sparse Model and Bayesian Information Criterion (2011)

Localization-based super-resolution microscopy (or called localization microscopy) rely on repeated imaging and localization of active molecules, and the spatial resolution enhancement of localization microscopy is built upon the sacrifice of its temporal resolution. Developing algorithms for high-density localization of active molecules is a promising approach to increase the speed of localization microscopy. Here we present a new algorithm called SSM_BIC for such purpose. The SSM_BIC combines the advantages of the Structured Sparse Model (SSM) and the Bayesian Information Criterion (BIC). Through simulation and experimental studies, we evaluate systematically the performance between the SSM_BIC and the conventional Sparse algorithm in high-density localization of active molecules. We show that the SSM_BIC is superior in processing single molecule images with weak signal embedded in strong background.
Gene mapping and gene enrichment by the avidin-biotin interaction: use of cytochrome-c as a polyamine bridge (1978)

A modification of previously described methods of electron microscopic gene mapping and of gene enrichment based on the avidin-biotin interaction is presented. The modification consists of coupling cytochrome-c instead of pentane diamine to the oxidized 2', 3' terminus of an RNA by Schiff base formation and BH-4 reduction. The RNA-cytochrome-c conjugate is purified by a simple chromatographic procedure; several biotins are attached to the cytochrome moiety by acylation. The extended arm between biotin and RNA gives efficient electron microscopic gene mapping of DNA:RNA-biotin hybrids with avidin-ferritin and avidin-polymethacylate sphere labels and efficient gene enrichment by buoyant banding of DNA:RNA-biotin:avidin-spheres in CsCl. A 1400 fold enrichment (thus, 25% pure) and a 90% yield of long Drosophila DNA strands with 5S RNA genes is achieved.
Empiriskt inriktad avhandling om idrott och välfärd : [Idræt som kommunal velfærd: Mentalitet, velfærd ogidrætspolitik i København,Ballerup og Skive 1870–1970 av Morten Mortensen] (2006)

Empiriskt inriktad avhandling om idrott och valfard : [Idraet som kommunal velfaerd: Mentalitet, velfaerd ogidraetspolitik i Kobenhavn,Ballerup og Skive 1870–1970 av Morten Mortensen]
From the Racetrack to the Road: Real-Time Trajectory Replanning for Autonomous Driving (2019)

In emergency situations, autonomous vehicles will be forced to operate at their friction limits in order to avoid collisions. In these scenarios, coordinating the planning of the vehicle's path and speed gives the vehicle the best chance of avoiding an obstacle. Fast reaction time is also important in an emergency, but approaches to the trajectory planning problem based on nonlinear optimization are computationally expensive. This paper presents a new scheme that simultaneously modifies the desired path and speed profile for a vehicle in response to the appearance of an obstacle, significant tracking error, or other environmental change. By formulating the trajectory optimization problem as a quadratically constrained quadratic program, solution times of less than 20 ms are possible even with a 10-s planning horizon. A simplified point mass model is used to describe the vehicle's motion, but the incorporation of longitudinal weight transfer and road topography means that the vehicle's acceleration limits are modeled more accurately than in comparable approaches. Experimental data from an autonomous vehicle in two scenarios demonstrate how the trajectory planner enables the vehicle to avoid an obstacle even when the obstacle appears suddenly and the vehicle is already operating near the friction limits.
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. (1998)

Although NFkappaB binding activity is induced during liver regeneration after partial hepatectomy, the physiological consequence of this induction is unknown. We have assessed the role of NFkappaB during liver regeneration by delivering to the liver a superrepressor of NFkappaB activity using an adenoviral vector expressing a mutated form of IkappaBalpha. This adenovirus (Ad5IkappaB) was almost exclusively expressed in the liver and inhibited NFkappaB DNA binding activity and transcriptional activity in cultured cells as well as in the liver in vivo. After partial hepatectomy, infection with Ad5IkappaB, but not a control adenovirus (Ad5LacZ), resulted in the induction of massive apoptosis and hepatocytes as demonstrated by histological staining and TUNEL analysis. In addition, infection with Ad5IkappaB but not Ad5LacZ decreased the mitotic index after partial hepatectomy. These two phenomena, increased apoptosis and failure to progress through the cell cycle, were associated with liver dysfunction in animals infected with the Ad5IkappaB but not Ad5LacZ, as demonstrated by elevated serum bilirubin and ammonia levels. Thus, the induction of NFkappaB during liver regeneration after partial hepatectomy appears to be a required event to prevent apoptosis and to allow for normal cell cycle progression.
Photodynamic inactivation of enveloped viruses using sapphyrin, a 22 pi-electron expanded porphyrin: possible approaches to prophylactic blood purification protocols (1990)

The in vitro photodynamic inactivation ofherpes simplex virus (HSV-1), an enveloped virus with a membranous coat, was studied using the decaalky sapphyrin 2. This new sensitizer, an unusual 22 icelectron "expanded porphyrin" with an absorption maximum at roughly 680 nm, generates singlet oxygen in roughly 25% quantum yield in its non-aggregated monomeric form and is very efficient for the photo-inactivation of HSV- 1 . It is as active as dihematoporphyrin derivative (DHE) on a per macrocycle basis and, because of light absorption by oxyhemoglobin, considerably more so in blood on a per mcident light intensity basis. Supporting fluorescence studies indicate that compound 2 has a high affinity for nonpolar environments, where it exists in its most active monomeric form, suggesting a mechanism of action that depends both on selective localization in the HSV- 1 viral membrane and accompanying efficient singlet oxygen production. In preliminary experiments with cell-free HIV-1 (also an enveloped virus), it was found that compound 2 effects a ca. 50% photo-killing with little dark toxicity at 4 jiM concentration and an essentially complete photo-eradication at 16 jiM concentration, as judged by standard reverse transcriptase assay. At this latter concentration, however, the light-induced viral inactivation is accompanied by considerable dark toxicity, which, on the basis of control experiments with uninfected cells, is ascribed to a high sensitivity of the H9 cell line employed and not to an overall, or inherent, cytotoxicity of the sapphyrin nucleus.
Generalized nonlinear inverse problems solved using the least squares criterion (1982)

We attempt to give a general definition of the nonlinear least squares inverse problem. First, we examine the discrete problem (finite number of data and unknowns), setting the problem in its fully nonlinear form. Second, we examine the general case where some data and/or unknowns may be functions of a continuous variable and where the form of the theoretical relationship between data and unknowns may be general (in particular, nonlinear integrodifferential equations). As particular cases of our nonlinear algorithm we find linear solutions well known in geophysics, like Jackson's (1979) solution for discrete problems or Backus and Gilbert's (1970) solution for continuous problems.
Data-driven crowd analysis in videos (2011)

In this work we present a new crowd analysis algorithm powered by behavior priors that are learned on a large database of crowd videos gathered from the Internet. The algorithm works by first learning a set of crowd behavior priors off-line. During testing, crowd patches are matched to the database and behavior priors are transferred. We adhere to the insight that despite the fact that the entire space of possible crowd behaviors is infinite, the space of distinguishable crowd motion patterns may not be all that large. For many individuals in a crowd, we are able to find analogous crowd patches in our database which contain similar patterns of behavior that can effectively act as priors to constrain the difficult task of tracking an individual in a crowd. Our algorithm is data-driven and, unlike some crowd characterization methods, does not require us to have seen the test video beforehand. It performs like state-of-the-art methods for tracking people having common crowd behaviors and outperforms the methods when the tracked individual behaves in an unusual way.
A Carbon Nanotube-Based Coulter Nanoparticle Counter (2004)

This Account reports on the properties and applications of carbon nanotube-based Coulter counters (CNCCs). CNCCs provide a means for determining the diameter and electrophoretic mobility (or electrokinetic surface charge) of individual nanoparticles dispersed in aqueous solutions, as well as the nanoparticle concentration. Such measurements do not require CNCC calibration or sample labeling. Because CNCCs measure the characteristics of individual particles, they provide the true average and polydispersity distribution of nanoparticle properties. CNCCs can differentiate between individual nanoparticles based on their surface charge and size, and CNCCs can be used to determine the apparent surface pK(a) of polymeric nanoparticles. Nanoparticle characterization by CNCC, electron microscopy, conductometric titration, and light scattering are compared.
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease (2002)

These observations demonstrate that Abeta 42 aggregation, and not Abeta 40, is the marker that is close to Alzheimer etiology. It should be the main target for the early biological diagnosis of AD and modeling. Furthermore, the spatial mismatch between amyloid ss-precursor protein (APP) and tau pathologies in cortical brain areas demonstrates that neurodegeneration is not a direct consequence of extracellular Abeta neurotoxicity. Hence, there is a synergetic effect of APP dysfunction, revealed by Abeta aggregation, on the neuron-to-neuron propagation of tau pathology.
Lazy process switching (2005)

Lazy switching enables very fast blocking intra-task IPC between kernel-implemented threads. This type of IPC can typically be entirely executed in user mode, although it operates on kernel objects. We hope that lazy switching adds the advantages of user level threads to kernel-level threads. The work on lazy switching is ongoing research in its early stage. Whether all its promising properties can make it to reality is still open.
Robotic Automation Process – The operating system for the digital enterprise (2018)

Abstract Robotic Process Automation (RPA) is going into a “maturity market”. The main vendor providers surpassed USD 1 billion in evaluation and the research they are launching these days on the market will change again radically the business landscape. It can be seen already what is coming next to RPA: intelligent optical character recognition (IOCR), chat-bots, machine learning, big data analytics, cognitive platforms, anomaly detection, pattern analysis, voice recognition, data classification and many more. As a result the top vendors developed partnerships with the main leading artificial intelligence providers, such as: IBM Watson, Microsoft Artificial Intelligence, Microsoft Cognitive services, blockchain, Google etc. On the business part, the consulting companies who are implementing the RPA solution are moving from developing Proof-of-Concepts (POCs) and Pilots to helping clients with RAP global roll-outs and developing Centre of Excellences (CoE). As a result, the experiences gathered so far by the author on this kind of projects will be tackled also in this paper. In this article will we will present also some data related to automation for different business areas (eg. Accounts Payable, Accounts Receivable etc) and how an assessment can be done correctly in order to decide if a process can be automatized and, if yes, up to which extent (ie. percent). Moreover, through the case studies we will provide (1) how now the RPA is integrated with Artificial Intelligence and Cloud, (2) how can be scaled in order to face hypes, (3) how can interpret data and (4) what savings these technologies can bring to the organizations. All the aforementioned services made Robotics Process Automation a very powerful tool since a year ago when the author did the last research. A process that was mainly not recommended for automation or was partially automated can be now fully automated with more advantages, such as: money, non-FTE savings and fulfillment time.
Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population (1999)

The activity of cytochrome oxidase (CO), the terminal enzyme of the mitochondrial electron transport chain, has been reported to be lower in the brains of Alzheimer disease (AD) patients. This suggests that a modification of mitochondrial DNA (mtDNA) may be responsible for this decrease of CO activity. Many mtDNA variants were found by different studies at a higher frequency in AD patients, suggesting that mtDNA variants could confer a genetic susceptibility to AD. In this study, we sequenced the entire mitochondrial genome region that encompasses the three CO genes and the 22 mitochondrial tRNA in 69 AD patients and 83 age-matched controls. We detected a total of 95 mtDNA variants. The allele frequencies of the majority of these variants were similar in patients and controls. However, a haplotype composed of three different modifications (positions: 5633, 7476, and 15812) was present in three of the 69 late-onset AD patients (4.3%) and also in 1 of 16 early-onset AD patients (6.2%) but not in control individuals. Given that one of these variants (15812) has already been shown to be associated with another neurodegenerative disease and that all three modifications are relatively conserved and their frequencies in the general population is only 0.1%, our data suggest that the presence of this haplotype may represent a risk factor for AD. We also found a significant association (P < 0.05) of two other variants at positions 709 (rRNA 12S) and 15928 (tRNA(Thr)). These two mtDNA variants are three times more frequent in control individuals compared with AD patients, suggesting that they may be protective against AD.
Nucleotide sequence of theAgrobacterium tumefaciensoctopine Ti plasmld-encodedtmrgene (1983)

The nucleotide sequence of the tmr gene, encoded by the octopine Ti plasmid from Agrobacterium tumefaciens (pTiAch5), was determined. The T-DNA, which encompasses this gene, is involved in tumor formation and maintenance, and probably mediates the cytokinin-independent growth of transformed plant cells. The nucleotide sequence of the tmr gene displays a continuous open reading frame specifying a polypeptide chain of 240 amino acids. The 5'- terminus of the polyadenylated tmr mRNA isolated from octopine tobacco tumor cell lines was determined by nuclease S1 mapping. The nucleotide sequence 5'-TATAAAA-3', which sequence is identical to the canonical "TATA" box, was found 29 nucleotides upstream from the major initiation site for RNA synthesis. Two potential polyadenylation signals 5'-AATAAA-3' were found at 207 and 275 nucleotides downstream from the TAG stopcodon of the tmr gene. A comparison was made of nucleotide stretches, involved in transcription control of T-DNA genes.