gebhart/patrepeval huggingface dataset:
A Health Status Questionnaire Using 30 Items From The Medical Outcomes Study (1991)

Many current health status instruments either are too long to use in many acquired immune deficiency syndrome (AIDS) clinical trials or omit important concepts. In this study, human immunodeficiency virus (HIV)-relevant items developed for the Medical Outcomes Study (MOS) from subscales for cognitive function, energy/fatigue, health distress, and a single quality of life item were added to a portion of the MOS Short-form General Health Survey. The resulting 30-item questionnaire reliably and distinctly measured ten aspects of health and took less than 5 minutes to complete. To test its validity, this modified measure was used to compare the health of 73 subjects with asymptomatic HIV infection and 44 with early AIDS-related complex (ARC). Compared with ARC subjects, asymptomatic individuals reported superior overall health, less pain, and better physical function, role function, cognitive function, and quality of life (rank-sum, P less than 0.02). Asymptomatic subjects' scores were higher on most subscales than the age-adjusted scores of MOS outpatients with hypertension, diabetes, recent myocardial infarction, or depression; ARC patients scored closest to hypertensive patients. This instrument, containing a subset of the MOS measures of health-related quality of life, may be a useful outcome measure for AIDS clinical trials.
An energy case for hybrid datacenters (2010)

Reducing energy consumption in datacenters is key to building low cost datacenters. To address this challenge, we explore the potential of hybrid datacenter designs that mix low power platforms with high performance ones. We show how these designs can handle diverse workloads with different service level agreements in an energy efficient fashion. We evaluate the feasibility of our approach through experiments and then discuss the design challenges and options of hybrid datacenters.
Antimicrobial Cycling: Lessons Learned From the Aminoglycoside Experience (2000)

Several discrete strategies have been suggested to prevent or reduce microbial resistance to antimicrobials, including optimal use of the agents (also known as good stewardship); control, removal, or restriction of antimicrobials; use of antimicrobials in combination; and rotational or cyclic use of antimicrobials. The latter strategy is attractive because it periodically removes from the institutional environment certain classes or specific agents that could induce or select resistance. Hospitalwide studies of aminoglycoside substitution employed from the late 1970s through the early 1990s, although not originally intended to test cycling or rotation of aminoglycosides, serendipitously provided data that may be useful in designing future studies. In particular, one 10-year study at the Minneapolis Veterans' Affairs Medical Center (MVAMC) rotated amikacin and gentamicin use over cycles of 12 to 51 months' duration. Significantly reduced resistance to gentamicin was found when amikacin was used, but resistance to gentamicin returned with the first gentamicin recycle. This was followed by reintroduction of amikacin a second time with decreased resistance to gentamicin and, finally, a second reintroduction of gentamicin without resistance to it recurring. Thus, some evidence of proof of principal can be garnered, albeit subject to considerable criticism. Critical examination of the design of the aminoglycoside rotation study and the unforeseen pitfalls is provided as a 13-element guidance list for design of future rotational studies. Rotational usage practices are likely to be most appropriate for drugs active against gram-negative bacilli because of the wide choices available for rotation. Future availability of new agents active against resistant gram-positive organisms will present the opportunity to cycle these agents as vancomycin substitutes. Careful monitoring of clinical outcomes and resistance will be required. Multicenter controlled trials that follow carefully designed protocols are most likely to produce statistically significant and clinically meaningful results.
Don't Get Caught in the Net: An Intellectual Property Practitioner's Guide to Using the Internet, 13 J. Marshall J. Computer & Info. L. 373 (1995) (1995)

The 'Net, AKA the Internet, has quickly become one of the most efficient and prevalent forms of communication. By linking through a common protocol, the Internet connects computer networks worldwide and provide seamless access to information. In this introductory guide to the Internet, the author takes readers -- IP practitioners, general legal practitioners, etc. -- on a tour of the Internet. The Internet began as part of the Defense Department's networking research in 1969 by the Advanced Research Projects Agency. In a program called ARPANET, the military attempted to design a interlinking computer networks that provides widespread connectivity without the vulnerability of relying on a centralized hub. This design, coupled with increasing use of personal computers, flourished tremendously and by 1998, there was 100 million users. The Internet provides many features including the electronic mail, usenet newsgroups, file transfer protocol, telnet, Gopher and the World Wide Web.
Of Mice and Men: Divergence of Gene Expression Patterns in Kidney (2012)

Since the development of methods for homologous gene recombination, mouse models have played a central role in research in renal pathophysiology. However, many published and unpublished results show that mice with genetic changes mimicking human pathogenic mutations do not display the human phenotype. These functional differences may stem from differences in gene expression between mouse and human kidneys. However, large scale comparison of gene expression networks revealed conservation of gene expression among a large panel of human and mouse tissues including kidneys. Because renal functions result from the spatial integration of elementary processes originating in the glomerulus and the successive segments constituting the nephron, we hypothesized that differences in gene expression profiles along the human and mouse nephron might account for different behaviors. Analysis of SAGE libraries generated from the glomerulus and seven anatomically defined nephron segments from human and mouse kidneys allowed us to identify 4644 pairs of gene orthologs expressed in either one or both species. Quantitative analysis shows that many transcripts are present at different levels in the two species. It also shows poor conservation of gene expression profiles, with less than 10% of the 4644 gene orthologs displaying a higher conservation of expression profiles than the neutral expectation (p<0.05). Accordingly, hierarchical clustering reveals a higher degree of conservation of gene expression patterns between functionally unrelated kidney structures within a given species than between cognate structures from the two species. Similar findings were obtained for sub-groups of genes with either kidney-specific or housekeeping functions. Conservation of gene expression at the scale of the whole organ and divergence at the level of its constituting sub-structures likely account for the fact that although kidneys assume the same global function in the two species, many mouse "models" of human pathologies do not display the expected phenotype.
Chemical vapor detection using nonlinear electrical properties of carbon nanotube bundles (2013)

We demonstrate the electrical transport behavior of carbon nanotubes (CNTs) upon exposure to organic analytes (namely ethanol, benzene, acetone and toluene). The resulting nonlinear current-voltage characteristics revealed a power law dependence of the differential conductivity on the applied bias voltage. Moreover, suppression of differential conductivity at zero bias is found to be dependent on different selective analytes. The power law exponent values have been monitored before, during and after exposure to the chemicals, which revealed a reversible change in the number of electron conducting channels. Therefore, the reduction in the number of conductive paths can be attributed to the interaction of the chemical analyte on the CNT surfaces, which causes a decrease in the differential conductivity of the CNT sample. These results demonstrate chemical selectivity of CNTs due to varying electronic interaction with different chemical analytes.
Reversible formation and disruption of micelles by control of the redox state of the head group (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible formation and disruption of micelles by control of the redox state of the head groupT. Saji, K. Hoshino, and S. AoyaguiCite this: J. Am. Chem. Soc. 1985, 107, 24, 6865–6868Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ja00310a020https://doi.org/10.1021/ja00310a020research-articleACS PublicationsRequest reuse permissionsArticle Views1093Altmetric-Citations190LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A second functional furin site in the SARS-CoV-2 spike protein (2021)

The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional furin site located in the spike protein. Furin still increased the infectivity of mutated SARS-CoV-2 pseudovirus in 293T-ACE2 cells when the canonical polybasic cleavage site (682-686) was deleted. However, K814A mutation eliminated the enhancing effect of furin on virus infection. Furin inhibitor prevented infection by 682-686-deleted SARS-CoV-2 in 293T-ACE2-furin cells, but not the K814A mutant. K814A mutation did not affect the activity of TMPRSS2 and cathepsin L but did impact the cleavage of S2 into S2' and cell-cell fusion. Additionally, we showed that this functional furin site exists in RaTG13 from bat and PCoV-GD/GX from pangolin. Therefore, we discovered a new functional furin site that is pivotal in promoting SARS-CoV-2 infection.
Routing Packets into Wireless Mesh Networks (2007)

Wireless mesh networks are a promising way to provide Internet access to fixed and mobile wireless devices. In mesh networks, traffic between mesh nodes and the Internet is routed over mesh gateways. On the forward path, i.e., from mesh nodes to Internet nodes, for all mesh nodes only route information for one destination, the gateways, needs to be maintained. However, on the backward path from the Internet to mesh nodes, an individual route for every mesh node is required. In this paper we investigate protocols for backward path routing in wireless mesh networks. Using simulation experiments with realistic mobility patterns of pedestrians and cars in cities, we compare three protocols, each of which represents a routing protocol family: (i) AODV with an extension for mesh networks, a reactive routing protocol, (ii) FBR, a proactive routing protocol, and (iii) GSR, a source routing protocol. Our results indicate that FBR has the highest packet delivery ratio but is not scalable to the network size. The extended AODV seems to be neither scalable nor does it achieve a high packet delivery ratio. A good compromise is provided by GSR, which is the most scalable to the network size and still achieves a high packet delivery ratio.
Repeatability and validity of astigmatism measurements. (1999)

For studies seeking to measure changes in astigmatism in normal eyes, cycloplegic autorefraction is the method of choice.
Infectivity-Enhancing Antibodies to Ebola Virus Glycoprotein (2001)

Ebola virus causes severe hemorrhagic fever in primates, resulting in mortality rates of up to 100%, yet there are no satisfactory biologic explanations for this extreme virulence. Here we show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) of the Zaire strain of Ebola virus enhances the infectivity of vesicular stomatitis virus pseudotyped with the GP. Substantially weaker enhancement was observed with antiserum to the GP of the Reston strain, which is much less pathogenic in humans than the Ebola Zaire and Sudan viruses. The enhancing activity was abolished by heat but was increased in the presence of complement system inhibitors, suggesting that heat-labile factors other than the complement system are required for this effect. We also generated an anti-Zaire GP monoclonal antibody that enhanced viral infectivity and another that neutralized it, indicating the presence of distinct epitopes for these properties. Our findings suggest that antibody-dependent enhancement of infectivity may account for the extreme virulence of the virus. They also raise issues about the development of Ebola virus vaccines and the use of passive prophylaxis or therapy with Ebola virus GP antibodies.
Substance Use Disorder Exacerbates Brain Electrophysiological Abnormalities in a Psychiatrically-III Population (1996)

Among the non-substance use disorder, psychiatrically-ill (PI) and substance use disorder, psychiatrically-ill (PI/SD) groups, significantly different brain map abnormalities were observed relative to an assessed normal population MANOVA (P = .017). Moreover, with regard to Spectral Analysis, ANOVA was significant at a P = .038, and we found a weighted linear trend of increased abnormal total spectral analysis (P = .0113), whereby substance use was significantly worse than controls. Moreover among the PI and PI/SD groups, significantly greater total evoked potential (EP) brain trap abnormalities were observed when compared with a characterized normal population (P = .0023) with increasing abnormalities as a function of substance use disorder as measured by a weighted linear trend (P = .0022). In order to determine the site of the EPS abnormalities, we evaluated these abnormalities by location. In this regard, we found all temporal abnormalities (AVBITA, see Table 2) among the PI and PI/SD groups to be significantly greater relative to an assessed normal population (P = .0026). Furthermore, we observed a linear trend of increased temporal abnormalities with increasing substance use disorder (P < .0008). In terms of bitemporal abnormalities (AVBIT) among the PI and PI/SD groups, we also found significantly more bitemporal lobe abnormalities in the PI/SD group compared to our control population (P = .009). Additionally, a weighted linear trend of increased abnormal bitemporal lobe abnormalities was observed with increasing substance use disorder (P = .0022). In the frontal lobe similar findings were observed. With AVBIFA the ANOVA was P < .011, with a weighted linear trend of P < .005 and the PI/SD group were significantly more abnormal than PI or CS on a Duncan Range test. It is noteworthy that in a selected group of depressed (Major Depressive Disorder Recurrent, 296.3) patients, we found profound abnormalities in the various brain map parameters tested. MANOVA and Univariate ANOVA's revealed significantly greater abnormalities in the PI and PI/SD groups compared to assessed controls. A MANOVA for total brain abnormalities was significant at P = .043 and univariate ANOVA's for composite measurements of TSA (P = .017), EPS (P = .0002), AVBITA (P = .000015), and AVBIT (P < .00002) are also significant. With regard to EPS and AVBITA a weighted linear trend was observed where there were increasing abnormalities with increasing substance use disorder, P = .0001 and P = .000003, respectively. Most importantly we found that in addition to increased abnormalities with increasing substance use disorder the PI/SD group had significantly more abnormalities compared to the PI group with regard to both the TSA (P < .05) and AVBIT (P < .05) composite parameters as meas
Security refresh (2010)

Phase change memory (PCM) is an emerging memory technology for future computing systems. Compared to other non-volatile memory alternatives, PCM is more matured to production, and has a faster read latency and potentially higher storage density. The main roadblock precluding PCM from being used, in particular, in the main memory hierarchy, is its limited write endurance. To address this issue, recent studies proposed to either reduce PCM's write frequency or use wear-leveling to evenly distribute writes. Although these techniques can extend the lifetime of PCM, most of them will not prevent deliberately designed malicious codes from wearing it out quickly. Furthermore, all the prior techniques did not consider the circumstances of a compromised OS and its security implication to the overall PCM design. A compromised OS will allow adversaries to manipulate processes and exploit side channels to accelerate wear-out.
Photoproduction of Hydrogen by Purple Bacteria: A Critical Evaluation of the Rate Limiting Enzymatic Steps (1993)

Abstract The enzymatic mechanisms and energetics of nitrogenase-catalyzed photoproduction of hydrogen from organic C-compounds by purple bacteria are discussed in respect to the question of which of the following three enzymes or enzyme systems are rate limiting for H 2 -production: (a) the nitrogenase-complex; (b) the enzymes and electron transport proteins involved in hydrogen transfer from the organic substrate(s) to nitrogenase; and (c) the system of photosynthetic ATP-regeneration. Calculations of maximum in vivo rates of photosynthetic ATPregeneration (gATP-values derived from growth rates), and of ATP-consumption by nitrogenase- catalyzed H 2 -production, and comparison of these rates with the specific activities of the enzymes of hydrogen or electron transfer from the C-substrate to the nitrogenase-complex, make it very likely that, in Rhodospirillum rubrum, nitrogenase-catalyzed H 2 -formation is limited by the availability of ATP and, possibly, of reducing power. In two other nonsulfur purple bacterial species (Rhodobacter capsulatus and Rhodobacter sphaeroides), H 2 -photoproduction is probably not energy-limited.
Recovery of Disturbed Endothelium-Dependent Flow in the Collateral-Perfused Rabbit Ischemic Hindlimb After Administration of Vascular Endothelial Growth Factor (1995)

To our knowledge, these findings constitute the first demonstration of successful pharmacological modulation of disturbed endothelium-dependent flow in the arterial circulation subserved by collateral vessels. This physiological benefit complements previously reported anatomic findings suggesting a favorable impact of angiogenic growth factors on collateral-dependent limb ischemia.
Automation and optimization of solid-phase microextraction (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAutomation and optimization of solid-phase microextractionCatherine L. Arthur, Lisa M. Killam, Karen D. Buchholz, Janusz. Pawliszyn, and John R. BergCite this: Anal. Chem. 1992, 64, 17, 1960–1966Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ac00041a034https://doi.org/10.1021/ac00041a034research-articleACS PublicationsRequest reuse permissionsArticle Views1443Altmetric-Citations516LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Top‐down or bottom‐up: Is security and defence policy in the EU a question of political will or military capability? (2000)

Much of the debate since the formation of the Common Foreign and Security Policy has focused on the political will, or lack thereof, as the principal obstacle to a successful European security policy. However, even if a cohesive will to develop a clear and operational foreign and security policy exists, the lack of military capabilities within the EU would make the implementation of that policy difficult, if not impossible, for the foreseeable future. The emerging political will to develop a CFSP needs to be paralleled by significant improvements in the force projection capabilities of the EU member states in order for a CFSP and future Common Defence Policy to be credible.
The Thermal Stability and Some Physical Properties of Silver Chlorite, Chlorate and Perchlorate* (1968)

Article The Thermal Stability and Some Physical Properties of Silver Chlorite, Chlorate and Perchlorate* was published on January 1, 1968 in the journal Zeitschrift für Physikalische Chemie (volume 57, issue 1_2).