gebhart/patrepeval huggingface dataset:
FrameSLAM: From Bundle Adjustment to Real-Time Visual Mapping (2008)

Many successful indoor mapping techniques employ frame-to-frame matching of laser scans to produce detailed local maps as well as the closing of large loops. In this paper, we propose a framework for applying the same techniques to visual imagery. We match visual frames with large numbers of point features, using classic bundle adjustment techniques from computational vision, but we keep only relative frame pose information (a <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">skeleton</i> ). The skeleton is a reduced nonlinear system that is a faithful approximation of the larger system and can be used to solve large loop closures quickly, as well as forming a backbone for data association and local registration. We illustrate the workings of the system with large outdoor datasets (10 km), showing large-scale loop closure and precise localization in real time.
The World's Speediest Trains (2007)

高速火车时代的真正开始,是在1964年时的日本,当年日本开发了shinkansen,即子弹头火车,时速高达201公里。现在看来,那可太“20世纪中期”了。今天,像法国的TGV系统这样的传统有轮火车时速可
SHORT INTEGUMENT (SIN1), a gene required for ovule development in Arabidopsis, also controls flowering time (1996)

The short integument (sin1) mutation causes a female-specific infertility, and a defect in the control of time to flowering in Arabidopsis. Female sterility of Sin- plants is due to abnormal ovule integument development and aberrant differentiation of the megagametophyte in a subset of ovules. An additional defect of sin1 mutants is the production of an increased number of vegetative leaf and inflorescence primordia leading to delayed flowering. The delayed flowering phenotype of sin1-1 is not due to a defect in the perception of day length periodicity or in gibberellic acid metabolism. Phenotypes of double mutant combinations of sin1 with terminalflower (tfl1) indicate that SIN1 activity is required for precocious floral induction typical in a tfl1 mutant. Unexpectedly, sin1-1 tfl1-1 plants do not make pollen, thus revealing a novel role for TFL1 in the anther. Early flowers of sin1-1 ap1-1 double mutants are transformed to long inflorescence-like shoots. A genetic model for the role of SIN1 in flowering time control is proposed.
Incorporating site-level knowledge to extract structured data from web forums (2009)

Web forums have become an important data resource for many web applications, but extracting structured data from unstructured web forum pages is still a challenging task due to both complex page layout designs and unrestricted user created posts. In this paper, we study the problem of structured data extraction from various web forum sites. Our target is to find a solution as general as possible to extract structured data, such as post title, post author, post time, and post content from any forum site. In contrast to most existing information extraction methods, which only leverage the knowledge inside an individual page, we incorporate both page-level and site-level knowledge and employ Markov logic networks (MLNs) to effectively integrate all useful evidence by learning their importance automatically. Site-level knowledge includes (1) the linkages among different object pages, such as list pages and post pages, and (2) the interrelationships of pages belonging to the same object. The experimental results on 20 forums show a very encouraging information extraction performance, and demonstrate the ability of the proposed approach on various forums. We also show that the performance is limited if only page-level knowledge is used, while when incorporating the site-level knowledge both precision and recall can be significantly improved.
Tailoring the Properties of Composite Piezoelectric Materials for Medical Ultrasonic Transducers (1985)

Transducers for medical ultrasonic imaging have been made from composite piezoelectric materials. This paper describes a simple physical model for the material properties which govern the thickness-mode oscillations in thin plates of PZT-rod/polymer composites. We consider the case where the lateral periodicity of the rods is much smaller than all relevant acoustic wavelengths. Expressions are derived for the effective material parameters in terms of the properties of the constituents. The composites' properties can then be tailored to device requirements by choosing appropriate components and by varying the volume fraction of piezoceramic. Our analysis reveals the need for a trade-off between the desired lower acoustic impedance and the undesired smaller electromechanical coupling that occurs as the volume fraction of piezoceramic is reduced. The predictions of this model are in good agreement with measurements made on rod-composite plates containing 5 to 35 percent PZT.
Msx homeobox genes inhibit differentiation through upregulation ofcyclin D1 (2001)

During development, patterning and morphogenesis of tissues are intimately coordinated through control of cellular proliferation and differentiation. We describe a mechanism by which vertebrate Msx homeobox genes inhibit cellular differentiation by regulation of the cell cycle. We show that misexpression of Msx1 via retroviral gene transfer inhibits differentiation of multiple mesenchymal and epithelial progenitor cell types in culture. This activity of Msx1 is associated with its ability to upregulate cyclin D1 expression and Cdk4 activity, while Msx1 has minimal effects on cellular proliferation. Transgenic mice that express Msx1 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) display impaired differentiation of the mammary epithelium during pregnancy, which is accompanied by elevated levels of cyclin D1 expression. We propose that Msx1 gene expression maintains cyclin D1 expression and prevents exit from the cell cycle, thereby inhibiting terminal differentiation of progenitor cells. Our model provides a framework for reconciling the mutant phenotypes of Msx and other homeobox genes with their functions as regulators of cellular proliferation and differentiation during embryogenesis.
Identification of a high-affinity binding site involved in the transport of endocannabinoids (2005)

Phytocannabinoids, such as the principal bioactive component of marijuana, Δ 9 -tetrahydrocannabinol, have been used for thousands of years for medical and recreational purposes. Δ 9 -Tetrahydrocannabinol and endogenous cannabinoids (e.g., anandamide) initiate their agonist properties by stimulating the cannabinoid family of G protein-coupled receptors (CB 1 and CB 2 ). The biosynthesis and physiology of anandamide is well understood, but its mechanism of uptake (resulting in signal termination by fatty acid amide hydrolase) has been elusive. Mounting evidence points to the existence of a specific anandamide transport protein; however, no direct evidence for this protein has been provided. Here, we use a potent, competitive small molecule inhibitor of anandamide uptake (LY2318912, IC 50 7.27 ± 0.510 nM) to identify a high-affinity, saturable anandamide transporter binding site (LY2318912; K d = 7.62 ± 1.18 nM, B max = 31.6 ± 1.80 fmol/mg protein) that is distinct from fatty acid amide hydrolase. Systemic administration of the inhibitor into rodents elevates anandamide levels 5-fold in the brain and demonstrates efficacy in the formalin paw-licking model of persistent pain with no obvious adverse effects on motor function. Identification of the anandamide transporter binding site resolves a missing mechanistic link in endocannabinoid signaling, and in vivo results suggest that endocannabinoid transporter antagonists may provide a strategy for positive modulation of cannabinoid receptors.
Reducing Substrate Pinning of Block Copolymer Microdomains with a Buffer Layer of Polymer Brushes (1999)

We study the range of orientational order of a single layer of cylindrical block copolymer microdomains annealed on several types of substrates. The orientational persistence length or nematic correlation length (ξ) is evaluated using recently developed imaging and analysis methods to measure the grain size of the block copolymer microdomains. We show that the substrate can lower ξ for block copolymers with a majority component that interacts strongly with the substrate, but this can be mitigated by attaching a buffer layer of polystyrene brushes to the substrate. In addition, we show that, for a block copolymer where the block that strongly interacts with the substrate is the minority component, the microdomain correlation length does not increase when substrates are treated with this buffer layer. We suggest that in this case the brushes do not increase ξ not only because of the lower volume fraction of the strongly interacting component but also because there are block copolymer wetting layers at the free and substrate interfaces that decouple the microdomains from the substrate in a similar manner as the polystyrene brushes.
d-Alanine transport in Escherichia coli (1984)

Conference Article| June 01 1984 d-Alanine transport in Escherichia coli GEOFFREY C. ROWLAND; GEOFFREY C. ROWLAND 1Department of Microbiology, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar IAN R. BOOTH IAN R. BOOTH 1Department of Microbiology, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1984) 12 (3): 505. https://doi.org/10.1042/bst0120505 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation GEOFFREY C. ROWLAND, IAN R. BOOTH; d-Alanine transport in Escherichia coli. Biochem Soc Trans 1 June 1984; 12 (3): 505. doi: https://doi.org/10.1042/bst0120505 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1984 Biochemical Society1984 Article PDF first page preview Close Modal You do not currently have access to this content.
The Stereoselective Synthesis of 2-Alkyl .gamma.-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy Esters (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereoselective Synthesis of 2-Alkyl .gamma.-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy EstersRobert V. Hoffman and Hwa-Ok KimCite this: J. Org. Chem. 1995, 60, 16, 5107–5113Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/jo00121a031https://doi.org/10.1021/jo00121a031research-articleACS PublicationsRequest reuse permissionsArticle Views642Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Colour tuning from green to red by substituent effects in phosphorescent tris-cyclometalated iridium(iii) complexes of carbazole-based ligands: synthetic, photophysical, computational and high efficiency OLED studies (2012)

Two series of fac-tris-cyclometalated iridium(III) complexes, series 1 from the 2-(carbazol-3′-yl)-pyridine ligands, and series 2 from the isomeric 2-(carbazol-2′-yl)-pyridine ligands, have been characterised. The photoluminescence and electroluminescence from series 2 complexes are red shifted compared to series 1 complexes, due to the increased electron donating ability of the carbazole unit in series 2. The attachment of trifluoromethyl and methoxy substituents to the pyridyl ring in these complexes results in colour tuning of phosphorescence energy maxima over the range 494–637 nm (green to red). These complexes possess predominantly 3MLCT (metal-to-ligand-charge transfer) excited states. DFT/TD-DFT computations correctly predict the phosphorescence emission maxima and show that the HOMOs in these complexes contain mixed iridium and carbazolyl character. The carbazolyl ligand contributions to the excited states increase in series 2 compared to series 1. Complexes of series 1 exhibit high phosphorescence quantum yields whereas complexes of series 2 show lower quantum yields. Solution processed organic light emitting devices (OLEDs) with series 1 complexes using the high triplet poly(9-vinylcarbazole) (PVK) as the host polymer exhibit very high performances of up to 40 cd A−1 and external quantum efficiency of 12%. For series 2 the highest current efficiency is 10.3 cd A−1 and external quantum efficiency of 5.6%.
Conformational Features of Tau Fibrils from Alzheimer’s Disease Brain Are Faithfully Propagated by Unmodified Recombinant Protein (2013)

Fibrils composed of tau protein are a pathological hallmark of several neurodegenerative disorders including Alzheimer's disease (AD). Here we show that when recombinant tau protein is seeded with paired helical filaments (PHFs) isolated from AD brain, the amyloid formed shares many of the structural features of AD PHFs. In contrast, tau amyloids formed with heparin as an inducing agent-a common biochemical model of tau misfolding-are structurally distinct from brain-derived PHFs. Using ultrastructural analysis by electron microscopy, circular dichroism, and chemical denaturation, we found that AD seeded recombinant tau fibrils were not significantly different than tau fibrils isolated from AD brain tissue. Tau fibrils produced by incubating recombinant tau with heparin had significantly narrower fibrils with a longer periodicity, higher chemical stability, and distinct secondary structure compared to AD PHFs. The addition of heparin to the reaction of recombinant tau and AD PHFs also corrupted the templating process, resulting in a mixture of fibril conformations. Our results suggest that AD-isolated PHFs act as a conformational template for the formation of recombinant tau fibrils. Therefore, the use of AD PHFs as seeds to stimulate recombinant tau amyloid formation produces synthetic tau fibers that closely resemble those associated with AD pathology and provides a biochemical model of tau misfolding that may be of improved utility for structural studies and drug screening. These results also demonstrate that post-translational modifications such as phosphorylation are not a prerequisite for the propagation of the tau fibril conformation found in AD.
Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer (2014)

Inefficient splicing in advanced prostate cancer provides a selective advantage through effects on microRNA networks but may render tumors vulnerable to agents that suppress rate-limiting steps in splicing.
Nano-graphene in biomedicine: theranostic applications (2012)

Owing to their unique physical and chemical properties, graphene and its derivatives such as graphene oxide (GO), reduced graphene oxide (RGO) and GO-nanocomposites have attracted tremendous interest in many different fields including biomedicine in recent years. With every atom exposed on its surface, single-layered graphene shows ultra-high surface area available for efficient molecular loading and bioconjugation, and has been widely explored as novel nano-carriers for drug and gene delivery. Utilizing the intrinsic near-infrared (NIR) optical absorbance, in vivo graphene-based photothermal therapy has been realized, achieving excellent anti-tumor therapeutic efficacy in animal experiments. A variety of inorganic nanoparticles can be grown on the surface of nano-graphene, obtaining functional graphene-based nanocomposites with interesting optical and magnetic properties useful for multi-modal imaging and imaging-guided cancer therapy. Moreover, significant efforts have also been devoted to study the behaviors and toxicology of functionalized nano-graphene in animals. It has been uncovered that both surface chemistry and sizes play key roles in controlling the biodistribution, excretion, and toxicity of nano-graphene. Biocompatibly coated nano-graphene with ultra-small sizes can be cleared out from body after systemic administration, without rendering noticeable toxicity to the treated mice. In this review article, we will summarize the latest progress in this rapidly growing field, and discuss future prospects and challenges of using graphene-based materials for theranostic applications.
Domino Michaelâ€“O-alkylation reaction: one-pot synthesis of 2,4-diacylhydrofuran derivatives and its application to antitumor naphthofuran synthesis (2001)

The reaction of enolates of 1,3-dicarbonyl compounds with α-halo-α,β-unsaturated carbonyl compounds affords 2,4-diacyldihydrofuran derivatives in the presence of DBU in THF. Chemical manganese dioxide oxidation of the hydrofurans leads to 2,4-diacylfuran derivatives. Application of the protocol enables short-step syntheses of antitumor naphthofuran natural products.
Reduction in Dislocation Density of Semipolar GaN Layers on Patterned Sapphire Substrates by Hydride Vapor Phase Epitaxy (2012)

This paper presents the growth of thick semipolar {1011}, {1122}, and {2021} GaN layers on n, r, and {2243} patterned sapphire substrates (PSSs), respectively, by hydride vapor phase epitaxy. The reduction rate of the dislocation density varied with growth planes. For {1011} GaN layers, the dislocation density drastically decreased at over 100 µm, which was as fast the reduction rate as in the case of the c-plane. It was revealed that the reduction rate of the dislocation density could be controlled by the proper selection of the growth plane. Finally, we fabricated 2 in. freestanding semipolar GaN substrates via self-separation.
Automated quantification of coronary plaque with computed tomography: comparison with intravascular ultrasound using a dedicated registration algorithm for fusion-based quantification (2012)

Automated quantification of coronary plaque on CT is feasible using dedicated quantitative software with a novel 3D registration algorithm.
Direct FLASH MR imaging of magnetic field inhomogeneities by gradient compensation (1988)

MR images based on gradient echoes are sensitive to artifacts caused by inhomogeneities of the static magnetic field. This paper describes the effects of local gradients in rapid FLASH MR images and presents a way of directly imaging affected areas. The idea is to compensate for signal losses due to mutual cancellation of dephased magnetizations by deliberate "misadjustments" of the refocusing part of the slice selection gradient. In contrast to conventional field imaging techniques no three-dimensional data acquisition or subsequent Fourier analysis is required to obtain images at a particular gradient strength. Conventional as well as inhomogeneity compensated FLASH images have been obtained on phantoms and human heads using a 2.35-T 40-cm magnet and a 1.5-T whole-body system, respectively.
Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor (2014)

This is the first report to our knowledge of successful treatment of DLBCL with anti-CD19 CAR T cells. These results demonstrate the feasibility and effectiveness of treating chemotherapy-refractory B-cell malignancies with anti-CD19 CAR T cells. The numerous remissions obtained provide strong support for further development of this approach.
End4p/Sla2p Interacts with Actin-associated Proteins for Endocytosis inSaccharomyces cerevisiae (1997)

end4-1 was isolated as a temperature-sensitive endocytosis mutant. We cloned and sequenced END4 and found that it is identical to SLA2/MOP2. This gene is required for growth at high temperature, viability in the absence of Abp1p, polarization of the cortical actin cytoskeleton, and endocytosis. We used a mutational analysis of END4 to correlate in vivo functions with regions of End4p and we found that two regions of End4p participate in endocytosis but that the talin-like domain of End4p is dispensable. The N-terminal domain of End4p is required for growth at high temperature, endocytosis, and actin organization. A central coiled-coil domain of End4p is necessary for formation of a soluble sedimentable complex. Furthermore, this domain has an endocytic function that is redundant with the function(s) of ABP1 and SRV2. The endocytic function of Abp1p depends on its SH3 domain. In addition we have isolated a recessive negative allele of SRV2 that is defective for endocytosis. Combined biochemical, functional, and genetic analysis lead us to propose that End4p may mediate endocytosis through interaction with other actin-associated proteins, perhaps Rvs167p, a protein essential for endocytosis.
(S)‐homoquisqualate: a potent agonist at the glutamate metabotropic receptor (1992)

The synthetic quisqualate analogue, (S)-homoquisqualate was examined for activity at the glutamate metabotropic receptor, in relation to its ability to stimulate phosphoinositide hydrolysis in rat pup cerebro-cortical slices. The compound produced a robust increase in hydrolysis (EC50 = 50.2 +/- 1.6 microM), which, in common with responses to quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate ((1S,3R)-ACPD), was antagonized uncompetitively by L-2-amino-3-phosphonopropionate (L-AP3). In contrast to quisqualate which exhibits low efficacy, (S)-homoquisqualate behaves as a full agonist at the metabotropic receptor.
Adrenal Androgens and Aging (2004)

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are the principal C19 steroids produced by the human adrenals. Their plasma levels decline to less than 20% of their maximal value during aging. Because these steroids appear to play a role in the maintenance of immunity, musculoskeletal integrity, and cardiovascular health, age-associated declines in adrenal androgen production may contribute to decreased immune function, osteoporosis, and atherosclerosis. Production of DHEA and DHEAS has been localized to the zona reticularis (ZR) of the adrenal cortex and can be modulated by intra-adrenal or extra-adrenal modulators. Extra-adrenal modulators include corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), insulin, and transforming growth factor beta (TGF-beta). Intra-adrenal regulators include enzymes and proteins involved in the steroidogenic pathway, specifically 17,20 lyase activity and DHEA sulfotransferase (DST). The natural histories of the emergence of adrenal androgen production and the ontogeny of the ZR appear to correlate closely. In addition, aging results in a decline in adrenal androgen production, and our data suggest a parallel diminution in the area represented by the ZR. This decline in the ZR may result from apoptosis, cellular and humoral immunity, or a reduction in the replicative capacity of the cells of the ZR.