gebhart/patrepeval huggingface dataset:
Effects of Local Administration of Vascular Endothelial Growth Factor on Mechanical Characteristics of the Semitendinosus Tendon Graft after Anterior Cruciate Ligament Reconstruction in Sheep (2006)

Exogenous VEGF application for ACL reconstruction can induce an increase in knee laxity and a decrease in the stiffness of the grafted tendon at least temporarily after ACL reconstruction. These potentially negative mechanical effects need to be taken into account when considering clinical use of VEGF.
The Two Faces of Potent Antitumor Duocarmycin‐Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity (2013)

Duocarmycin-derived seco-cyclopropabenzindole (CBI) drugs have been shown to bind DNA and an aldehyde dehydrogenase (ALDH1A1) in lung cancer cells. The removal of the DNA-binding indole moiety results in a CBI compound that does not bind to DNA in whole cells but still exhibits remarkable cytotoxicity. This CBI compound has an increased affinity for ALDH1A1. Rh=rhodamine. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Space-Time Coding in Mobile Satellite Communications Using Dual-Polarized Channels (2006)

The use of dual-orthogonal polarization (horizontal/vertical or circular right-hand/left-hand polarizations) can increase the rate of transmission of satellite communication systems by a factor of two. However, the cross polar discriminations (XPDs) of the satellite and earth station antennas may be large enough to severely interfere between the two polarizations. In this paper, we investigate the use of space-time coding techniques in satellite-land mobile systems using dual-polarized transmit and receive antennas. In particular, we show that we can achieve significant gains by using layered space-time coding concepts and iterative detection and decoding receivers in communications systems employing polarization diversity channels in the presence of line-of-sight components.
Gamma Spectroscopy Analysis of Produced Water from Selected Flow Stations in Delta State, Nigeria (2013)

This paper present the findings of naturally occurring radionuclides (226Ra, 228Ra and 40K) carried out on produced water collected from seven oil and gas fields onshore of Delta State, using gamma spectroscopy. Twenty- one produced water samples from seven flow stations waste pit were collected within the oil fields using standard methods. The average specific activity concentrations for the radionuclides 40K, 226Ra and 228Ra are 48.7813.67Bql-1, 6.042.48Bql-1 and 5.182.14Bql-1 respectively. These obtained values are higher than the WHO, 2008 recommended standard limit of 10Bql-1, 1.0Bql-1 and 0.1Bql-1 for 40K, 226Ra and 228Ra respectively. Radium equivalent have average activity concentration of 14.365.55Bql-1 while the average absorbed dose rate of 6.68mSvy-1 was found to be higher than the UNSCEAR 2000 acceptable standard of 1.5mSvy-1. Although the hazard indices (Hex, Hin) calculated are still within their tolerable levels, the estimated committed effective dose due to intake of the sampled water for all the produced water considered are far above the ICRP 0.1 mSvyr-1 maximum permissible limit. The result indicates some level of water pollution in the studied water samples. This work will add to the world data base of natural radionuclide in produced water from crude oil.
Natural variation of nitrate uptake and nitrogen use efficiency in Arabidopsis thaliana cultivated with limiting and ample nitrogen supply (2010)

Eighteen accessions of Arabidopsis thaliana were grown with low (N-) and high (N+) nitrogen supply. N uptake was monitored by feeding plants with 15N-enriched nutritive solution over 24 h. Biomass [fresh matter (FM) and dry matter (DM)], N concentration (N%), and 15N content were monitored and computed to determine the nitrogen use efficiency (NUE) and nitrogen uptake efficiency (NupE). NUE has been estimated as the ratio between biomass and N concentration (DM/N%) and NupE as the concentration of 15N in plants [microg (g(-1) DM)]. Accession traits were analysed to detect common and individual genotype features. The genetic variation in NUE at high N input was mainly explained by variation in N uptake. Even though plants managed N uptake and N metabolism differently under N+ and N-, NUE was similar in these two conditions, showing that NUE was exclusively genetically determined. Hierarchical classification revealed that the physiological classes arising were similar under N- and N+. Both wasteful and efficient genotypes were detected. Three extreme genotypes, Col-0, Bur-0, and Tsu-0, were noted. Bur-0 and Tsu-0 exhibited high NUE and large biomass. Col-0 showed the reverse: low NUE and low biomass. Bur-0 appeared poorly tolerant of a high N supply. The present data will facilitate the choice of Arabidopsis accessions as parents of recombinant inbred line populations suitable for the mapping of quantitiative trait loci related to NUE, NupE, and N storage capacity.
Recovery of Myelin after Induction of Oligodendrocyte Cell Death in Postnatal Brain (2005)

A transgenic mouse line (Oligo-TTK) was established to monitor oligodendrocyte cell death and myelin formation in the CNS. The expression of a conditionally toxic gene, the herpes simplex virus-1 thymidine kinase (HSV1-TK), was made under control of the MBP (myelin basic protein) gene promoter. A truncated form of the HSV1-TK (TTK) gene was used to avoid both bystander effect resulting from leaking in thymidine kinase activity and sterility in transgenic males observed in previous transgenic mice. The transgene was expressed in the CNS with a restricted localization in oligodendrocytes. Oligodendrocyte proliferation and myelin formation are therefore tightly controlled experimentally by administration of ganciclovir (GCV) via the induction of oligodendrocyte cell death. The most severe and irreversible hypomyelination was obtained when GCV was given daily from postnatal day 1 (P1) to P30. Oligodendrocyte plasticity and myelin recovery were analyzed in another phenotype generated by GCV treatment from P1 to P15. In this model, after dysmyelination, an apparent normal behavior was restored with no visible pathological symptoms by P30. Proliferating cells, which may be implicated in myelin repair in this model, are detected primarily in myelin tracts expressing the oligodendrocyte phenotype. Therefore, the endogenous potential of oligodendrocytes to remyelinate was clearly demonstrated in the mice of this study.
FLT3 internal tandem duplication in CD34+/CD33- precursors predicts poor outcome in acute myeloid leukemia (2006)

Acute myeloid leukemia (AML) is a clonal disease characterized by heterogeneous involvement of hematopoietic stem cell/ progenitor cell populations. Using FLT3 internal tandem duplication (FLT3/ITD) as a molecular marker, we tested the hypothesis that clinical outcome in AML correlates with disease involvement of CD34 / CD33 precursors. Diagnostic specimens from 24 children with FLT3/ITD-positive AML were sorted by fluorescenceactivated cell sorting (FACS), and resultant CD34 /CD33 and CD34 /CD33 progenitors were analyzed directly and after colony-forming cell (CFC) assay for the presence of FLT3/ITD. FLT3/ITD was present in all CD34 /CD33 patient samples. In contrast, FLT3/ITD was detected in CD34 /CD33 progenitors in only 19 of 24 samples. A bipotent progenitor was affected in a subset of patients, as evidenced by the presence of FLT3/ITD in both granulocyte-macrophage colonyforming unit (CFU-GM) and erythroid burst-forming unit (BFU-E) colonies. Those patients in whom CD34 /CD33 precursors harbored the FLT3/ITD had worse clinical outcome; actuarial event-free survival (EFS) at 4 years from study entry for those patients with and without FLT3/ITD detection in CD34 /CD33 progenitors was 11% 14% versus 100% 0%, respectively (P .002). This study suggests that FLT3/ITD involvement in CD34 /CD33 precursors is heterogeneous and that detection of the mutation in the less-mature progenitor population may be associated with disease resistance. (Blood.
Density Functional Study of Benzene Adsorption on Pt(111) (2002)

The adsorption of benzene on Pt(111) was analyzed using first-principles density functional theoretical cluster and periodic slab calculations. The preferred adsorption site at low coverage is the bridge(30) site with an adsorption energy of 117 kJ/mol. At the bridge(30) site, two of the C pz orbitals are well aligned for overlap with the metal dz2 and dyz orbitals, leading to a strong C−Pt bond and a strong adsorption energy. The molecule's second important site is the hollow(0) site with an adsorption energy of 75 kJ/mol. Comparing calculated and experimental vibrational frequencies confirms the preference for the bridge site at low coverage and also indicates that adsorption at the hollow(0) site becomes preferred at higher coverage. Adsorption at the hollow(30), the bridge(0) and at the atop sites was found to be unfavorable.
Synthesis of the corticoid side chain (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of the corticoid side chainAndrzej Robert Daniewski and Wanda WojciechowskaCite this: J. Org. Chem. 1982, 47, 15, 2993–2995Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/jo00136a035https://doi.org/10.1021/jo00136a035research-articleACS PublicationsRequest reuse permissionsArticle Views544Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Buried heterostructure DFB laser integrated with ridge waveguide electroabsorption modulator with over 20 GHz bandwidth (1997)

A buried heterostructure laser and a ridge waveguide modulator have been successfully integrated using a novel taper-jointed coupling technique. The laser exhibited a low threshold of 8.6 mA, a small α-parameter of 0 at -2 V bias and a wide modulation bandwidth over 20 GHz.
Thioredoxin is the bacterial protein encoded by fip that is required for filamentous bacteriophage f1 assembly (1985)

Escherichia coli mutants defective in the fip gene contain reduced levels of thioredoxin activity. F' derivatives of trxA mutants failed to support f1 growth, although suppressors of an amber trxA mutation restored both thioredoxin activity and the Fip+ phenotype. Plasmids carrying the trxA gene restored the Fip+ phenotype to fip strains.
Effect of transfection of microRNA-10b and antisense microRNA-10b on the expression of RhoC in human pancreatic cancer cell line AsPC-1 (2014)

Objective To observe the effect of microRNA (miR)-10b on the expression of RhoC in human pancreatic cancer cell line AsPC-1.Methods The recombinant eukaryotic expression plasmid vector with miR-10b sequence [pPG-CMV-enhanced green fluorescent protein (EGFP)-miR-10b] or the antisense sequence was transfected into human pancreatic cancer cell line (AsPC-1) with lipofectamine,and the efficiency of the instant expression was confirmed by real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) and fluorescence microscope.The difference of the migration and invasion of the cells was evaluated by matrigel assay,and the expression of RhoC was evaluated by Western blotting.Results The expression of miR-10b in the sense group was increased by 10 folds,and in antisense group,the expression was decreased to 14％ compare to the control (P ＜ 0.05).The expression of RhoC protein in the sense group was (95.7 ± 8.5) unit,and that in the antisense group (28.5 ± 5.7) unit (P ＜0.05).As compared to the antisense group,the number of migrating and penerating cells was decreased from (85 ±7) and (35 ±9) to (32±5) and (8 ±3) in the sense group (P＜0.05) Conclusion miR10b can up-regulate the expression of RhoC,and promote the migration and invasion of the AsPC-1 cells.

Key words: 
MicroRNA-10b;  Pancreatic cancer ;  Migration ;  Invasion
Sex differences in arithmetic computation and reasoning in prepubertal boys and girls (1988)

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Recent Advances in Near-Infrared Reflectance Spectroscopy (1992)

Abstract A proliferation of applications for near-infrared reflectance spectroscopy has been driven by recent advances in instrumentation and chemometrics. These include the development of smaller, portable instruments with no moving parts, suitable for process environments, and new data treatments and calibration algorithms to model nonlinear relationships between spectra and chemical constituents. The intent of this review is to focus on recent developments in near-infrared reflectance spectroscopy, including chemometrics and new applications of NIR reflectance in several diverse fields, rather than to address indepth the historical development of NIR. Certain topics, such as chemometrics, deserve a comprehensive review by themselves, and the reader is urged to consult the original sources for greater depth. As a newcomer to the field, I have attempted to present those topics which may be of greater interest to the novice.
Fully integrated hybrid silicon two dimensional beam scanner (2015)

In this work we present the first fully-integrated free-space beam-steering chip using the hybrid silicon platform. The photonic integrated circuit (PIC) consists of 164 optical components including lasers, amplifiers, photodiodes, phase tuners, grating couplers, splitters, and a photonic crystal lens. The PIC exhibited steering over 23° x 3.6° with beam widths of 1° x 0.6°.
Major histocompatibility complex class II polymorphisms in primates (1999)

In the past decade, the major histocompatibility complex (MHC) class II region of several primate species has been investigated extensively. Here we will discuss the similarities and differences found in the MHC class II repertoires of primate species including humans, chimpanzees, rhesus macaques, cotton-top tamarins and common marmosets. Such types of comparisons shed light on the evolutionary stability of MHC class II alleles, lineages and loci as well as on the evolutionary origin and biological significance of haplotype configurations.
Reduction of Simian-Human Immunodeficiency Virus 89.6P Viremia in Rhesus Monkeys by Recombinant Modified Vaccinia Virus Ankara Vaccination (2001)

Since cytotoxic T lymphocytes (CTLs) are critical for controlling human immunodeficiency virus type 1 (HIV-1) replication in infected individuals, candidate HIV-1 vaccines should elicit virus-specific CTL responses. In this report, we study the immune responses elicited in rhesus monkeys by a recombinant poxvirus vaccine and the degree of protection afforded against a pathogenic simian-human immunodeficiency virus SHIV-89.6P challenge. Immunization with recombinant modified vaccinia virus Ankara (MVA) vectors expressing SIVmac239 gag-pol and HIV-1 89.6 env elicited potent Gag-specific CTL responses but no detectable SHIV-specific neutralizing antibody (NAb) responses. Following intravenous SHIV-89.6P challenge, sham-vaccinated monkeys developed low-frequency CTL responses, low-titer NAb responses, rapid loss of CD4+ T lymphocytes, high-setpoint viral RNA levels, and significant clinical disease progression and death in half of the animals by day 168 postchallenge. In contrast, the recombinant MVA-vaccinated monkeys demonstrated high-frequency secondary CTL responses, high-titer secondary SHIV-89.6-specific NAb responses, rapid emergence of SHIV-89.6P-specific NAb responses, partial preservation of CD4+ T lymphocytes, reduced setpoint viral RNA levels, and no evidence of clinical disease or mortality by day 168 postchallenge. There was a statistically significant correlation between levels of vaccine-elicited CTL responses prior to challenge and the control of viremia following challenge. These results demonstrate that immune responses elicited by live recombinant vectors, although unable to provide sterilizing immunity, can control viremia and prevent disease progression following a highly pathogenic AIDS virus challenge.
Titanium-induced dicarbonyl-coupling reactions (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTitanium-induced dicarbonyl-coupling reactionsJohn E. McMurryCite this: Acc. Chem. Res. 1983, 16, 11, 405–411Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ar00095a003https://doi.org/10.1021/ar00095a003research-articleACS PublicationsRequest reuse permissionsArticle Views2030Altmetric-Citations331LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Italian North (2000)

on 23 October 1310, the emperor-elect, Henry of Luxemburg, completed his crossing of the Alps. A principal reason for his expedition was to receive an imperial coronation in Rome; he was also determined to recover his rights within the kingdom of Italy, a constituent part of the western empire whose frontiers encompassed much of the north of the peninsula. Connected to both aims was a desire to achieve a general pacification of his Italian lands. But that task was formidable. The area had no recent tradition of centralised let alone imperial rule. It was composed of a mosaic of lordships (signorie) and communes, protective of their autonomy while generally jealous of their neighbours. Rivalries had economic roots: the control of land and the trade routes within the region which connected it with the rest of Europe and the Mediterranean. They also had a political dimension polarised around allegiances which made up in ferocity and tenacity what they lacked in consistent ideological content. The Ghibellines looked to the empire and its Italian allies for support and justification. The Guelfs allied themselves with the papacy whose leading protagonists in Italy were the commune of Florence and the Angevins, who as well as being counts of Provence and kings of Naples, had lands in Piedmont. And not only did these allegiances express divisions within the region and Italy as a whole; they were also linked to factions struggling for ascendancy within individual cities.
Polarization-sensitive optical coherence tomography with decorrelated channels (2004)

We describe a Polarization Sensitive Optical Coherence Tomography (PS-OCT) system with de-correlated horizontal and vertical channels. Construction of PS-OCT depth-resolved images is achieved with a scanning bulk Michelson interferometer and a broadband TiAl<sub>2</sub>O<sub>3</sub> femtosecond laser source. We de-correlate and delay horizontal and vertical channels using a birefringent crystal in the source path and calcite prism pairs in the sample and reference paths. Cross-correlation and phase changes between horizontal and vertical channels are measured at different reference-sample optical delays in correlated and de-correlated PS-OCT. PS-OCT with de-correlated (DPS-OCT) channels can broaden applications to include de-correlated Doppler imaging of blood flow and imaging the retinal nerve fiber layer with delayed channels. We achieve a differential delay of 0-400 microns between vertical and horizontal channels by translating the calcite prisms. DPS-OCT system design and experimental measurements are presented and discussed.
Parameter extraction for large signal noise models and simulation of noise in large signal circuits like mixers and oscillators (1993)

This paper shows how to obtain an equivalent circuit model for bipolar transistors and FEITs to generate a bias-dependent model. The bias-dependent model is required as a seed to obtain starting values for a large signal model. Particularly in the case of calculating noise under large signal conditions, the bias-dependent noise parameters for both bipolar transistors and FETs have to be obtained. For verification purposes, these methods have been implemented in the nonlinear circuit simulator, Microwave Harmonica. We have employed double balanced diode mixers, both active and passive (switching) FET mixers as well as a variety of oscillators to show that the nonlinear noise analysis capabilities are verified in these applications.
Dynamic tensile‐failure‐induced velocity deficits in rock (1991)

Planar impact experiments were employed to induce dynamic tensile failure in Bedford limestone. Rock discs were impacted with aluminum and polymethyl methacralate (PMMA) flyer plates at velocities of 10 to 25 m/s. Tensile stress magnitudes and duration were chosen so as to induce a range of microcrack growth insufficient to cause complete spalling of the samples. Ultrasonic P‐ and S‐wave velocities of recovered targets were compared to the velocities prior to impact. Velocity reduction, and by inference microcrack production, occurred in samples subjected to stresses above 35 MPa in the 1.3 μs PMMA experiments and 60 MPa in the 0.5 μs aluminum experiments. Using a simple model for the time‐dependent stress‐intensity factor at the tips of existing flaws, apparent fracture toughnesses of 2.4 and 2.5 MPa m ½ are computed for the 1.3 and 0.5 μs experiments. These are a factor of ∼ 2 to 3 greater than quasi‐static values. The greater dynamic fracture toughness observed may result from microcrack interaction during tensile failure. Data for water‐saturated and dry targets are indistinguishable.