gebhart/patrepeval huggingface dataset:
Web caching for database applications with Oracle Web Cache (2002)

We discuss several important issues specific to Web caching for content dynamically generated from database applications. We present the techniques employed by Oracle Web Cache to address these issues. They include: content disambiguation based on information in addition to the URL, transparent session management, partial-page caching for personalization, and broad-scope invalidation with performance assurance heuristics.
Osteoblast and osteoclast cell number and cell activity in postmenopausal osteoporosis. (1986)

This study evaluates osteoblast and osteoclast cell numbers and cell activities determined from quantitative histology of trabecular bone in human iliac crest bone biopsies. Subjects studied were postmenopausal osteoporotic patients (aged 53-81) for whom total body calcium and urine and serum clinical data were also available. Only 39% of the osteoclasts identified by acid phosphatase content were multinucleate; however, a significant correlation between multinucleate osteoclasts and the total number of osteoclasts was found (r = 0.87; p less than 0.001). The mean number of osteoclasts per square millimeter of total tissue area was 0.96 (+/- 0.14, SEM, n = 36); the mean number of osteoblasts was 6.8 (+/- 1.5, n = 14)/mm2 tissue area. Computed osteoclast activity (square millimeter bone resorbed per osteoclast nucleus per day) was 2.6 X 10(-4) +/- 1.0 X 10(-4) (n = 13). Computed osteoblast activity (square millimeter bone formed per osteoblast per day) was 2.9 X 10(-5) +/- 8.8 X 10(-6) (n = 13). Calculated mean rate of bone resorption was 1.6 X 10(-4) +/- 3.4 X 10(-5) mm2 bone resorbed per mm2 total tissue area per day (n = 19). These data indicate that although osteoclasts are not numerous in the iliac crest of postmenopausal osteoporotics, the individual osteoclast activity (in square millimeter bone resorbed osteoclast cell unit per day) is significantly greater (p less than 0.001) than the osteoblast activity (in square millimeter matrix deposited per cell per day). These data also point out that greater consideration should be given to the role that osteoclast cell activity may play in human postmenopausal osteoporosis.
Computer simulations of bilayer membranes: Self-assembly and interfacial tension (1998)

Binary Lennard-Jones fluids consisting of “solvent” and “surfactant” molecules are studied as simplified model systems for amphiphilic molecules in solution. Using Monte Carlo and molecular dynamics simulations, we observe the self-assembly of the surfactant molecules into bilayer membranes. These bilayers are fluid since the surfactants exhibit rapid lateral diffusion. We also measure the interfacial tension and the compressibility modulus of these bilayers. We show that they exhibit a tensionless state and characterize the corresponding stress profile. In this way, we bridge the gap between previous theoretical studies which were based (i) on discrete models with atomic resolution and (ii) on continuum models in which the bilayer membrane is treated as a smooth surface.
Increased immunogenicity of ehrlich ascites cells after heat treatment (1972)

Immunization of Swiss mice with Ehrlich ascites cells which had been exposed in vitro to 42.C for 3 hours is more effective, so far as subsequent tumor transplantation is concerned, than immunization with radiation-inactivated cells or with cells exposed to 42.5C for 6 hours. These results, which indicate that upon moderate heat treatment there is a definite increase of the immunogencity of these cells, may have some relevance as to the mechanism of the delayed tumor regression which is often clinically observed after hyperthermic perfusion.
Muscle damage is not a function of muscle force but active muscle strain (1993)

Contractile properties of rabbit tibialis anterior muscles were measured after eccentric contraction to investigate the mechanism of muscle injury. In the first experiment, two groups of muscles were strained 25% of the muscle fiber length at identical rates. However, because the timing of the imposed length change relative to muscle activation was different, the groups experienced dramatically different muscle forces. Because muscle maximum tetanic tension and other contractile parameters measured after 30 min of cyclic activity with either strain timing pattern were identical (P > 0.4), we concluded that muscle damage was equivalent despite very different imposed forces. This result was supported by a second experiment in which the same protocol was performed at one-half the strain (12.5% muscle fiber length). Again, there was no difference in maximum tetanic tension after cyclic 12.5% strain with either strain timing. Data from both experiments were analyzed by two-way analysis of variance, which revealed a highly significant effect of strain magnitude (P < 0.001) but no significant effect of stretch timing (P > 0.7). We interpret these data to signify that it is not high force per se that causes muscle damage after eccentric contraction but the magnitude of the active strain (i.e., strain during active lengthening). This conclusion was supported by morphometric analysis showing equivalent area fractions of damaged muscle fibers that were observed throughout the muscle cross section. The active strain hypothesis is described in terms of the interaction between the myofibrillar cytoskeleton, the sarcomere, and the sarcolemma.
Inhibition of skin carcinogenesis in vivo by caffeine and other agents. (1978)

The induction of skin cancer in mice of the Swiss (Carshalton) strain, by repeated irradiation with UV-light, was strikingly reduced by the local application of caffeine prior to each exposure. Theophylline displayed the same activity. These two substances have been selected as probable inhibitors of error-prone, postreplicative DNA repair. Conversely, reductone and chloroquine, which are considered as inhibitors of the error-free, prereplicative excision repair, did not modify the incidence of the tumors. Special emphasis has been given to the histologic behavior of radiolabeled caffeine in the normal and UV-irradiated epidermis of the mouse in vivo and to the ability of mouse epidermal cells in vitro to repair DNA after UV irradiation.
BCR-ABL and BCR proteins: biochemical characterization and localization. (1990)

The Philadelphia translocation results in the expression of a family of chimaeric proteins in which a portion of the bcr protein is fused to c-abl protein. Using antibodies which recognize different portions of the bcr gene and abl gene products we have compared the normal bcr products with their chimaeric counterparts. We first conclude that the enhanced kinase activity of the rearranged bcr-abl products (p210 and p190) is recovered almost exclusively from the cytosolic fraction. This methodology was confirmed by the demonstration that in cells transformed by the Abelson murine leukemia virus (A-MuLV) the gag-abl kinase activity was recovered equally from the membrane and cytosolic fractions, in agreement with previous studies. To determine whether the distribution of kinase activity reflected the bulk distribution of the bcr-abl proteins, in vivo labeling followed by subcellular fractionation was performed. Both normal bcr proteins and the p210 bcr-abl protein were recovered from the cytosolic fraction with little detectable amounts present in other fractions. In vivo labeling was also used to demonstrate that both normal bcr products and the p210 bcr-abl had a relatively long half-life. It is concluded that bcr-abl products, like normal bcr products are located in the cytosolic fraction.
The Bvg accessory factor (Baf) enhances pertussis toxin expression in Escherichia coli and is essential for Bordetella pertussis viability (2000)

Pertussis toxin expression in the Gram-negative respiratory pathogen, Bordetella pertussis, is regulated by the BvgAS two-component system. Previous studies suggested that an additional gene encoding a Bvg accessory factor (Baf) was required, along with BvgAS, for expression of a ptx-lacZ fusion in Escherichia coli grown in rich medium. However, other studies showed that BvgAS is sufficient for ptx-lacZ expression in minimal medium. Here we show that Baf acts with BvgAS to further increase ptx-lacZ expression in E. coli grown in minimal media and this is concomitant with a two-fold increase in BvgA protein levels. Gene replacement experiments show that baf is essential for viability of B. pertussis, suggesting that Baf affects the expression of other genes in addition to ptx.
Onychomycosis: Pathogenesis, Diagnosis, and Management (1998)

Although not life-threatening, onychomycosis (a fungal infection of the nail, usually caused by a dermatophyte) constitutes an important public health problem because of its high prevalence (about 10% of the U.S. population) and associated morbidity. The disease can have certain negative consequences for patients, such as pain, and can potentially undermine work and social lives. This review discusses the etiology, classification, diagnosis, and treatment of onychomycosis. Four types of onychomycosis are recognized based on the site and pattern of fungal invasion. Dermatophyte fungi are the predominant pathogens, but yeasts (especially Candida albicans) and nondermatophyte molds may also be implicated. Accurate diagnosis requires direct microscopy and fungal culture. The differential diagnosis includes psoriasis, lichen planus, onychogryphosis, and nail trauma. Onychomycosis is more difficult to treat than most dermatophytoses because of the inherent slow growth of the nail. Older antifungal agents (ketoconazole and griseofulvin) are unsuitable for onychomycosis because of their relatively poor efficacy and potential adverse effects. Three recently developed antimycotic agents (fluconazole, itraconazole, and terbinafine) offer high cure rates and good safety profiles. In addition, the short treatment times (< 3 months) and intermittent dosing schedules are likely to enhance compliance and reduce the costs of therapy.
Reversible gelation of polyoxazoline by means of Diels-Alder reaction (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReversible gelation of polyoxazoline by means of Diels-Alder reactionYoshiki Chujo, Kazuki Sada, and Takeo SaegusaCite this: Macromolecules 1990, 23, 10, 2636–2641Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ma00212a007https://doi.org/10.1021/ma00212a007research-articleACS PublicationsRequest reuse permissionsArticle Views3491Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Effects of Secondary Electrons from a Silion Substrate on SR X-Ray Lithography (1989)

The effects of secondary electrons from an Si substrate have been investigated quantitatively in SR lithography. It is confirmed that secondary electrons from an Si substrate produce undercuts of 0.1 µm in depth in the replicated resist patterns. The Si KLL Auger electron proves to be the main cause of this problem. This is ascertained through analysis of many kinds of secondary electrons. Moreover, eliminating the wavelength which excites the Si 1s electron from the exposing SR is one promising way to lessen this problem. The resolution of SR lithography is also confirmed to improve to less than 0.1 µm in the practical wavelength, if secondary electrons from the substrate are effectively minimized.
Perturbation-Assisted PAPR Reduction for Large-Scale MIMO-OFDM Systems via ADMM (2016)

We consider the problem of peak-to-average power ratio (PAPR) reduction for orthogonal frequency-division multiplexing (OFDM) based large-scale multiple-input multipleoutput (MIMO) systems. A novel perturbation-assisted scheme is developed to reduce the PAPRs of the transmitted signals by exploiting the redundant degrees-of-freedom (DoFs) inherent in the large-scale antenna array. Specifically, we introduce artificial perturbation signals to the frequency-domain precoded signals, with the aim of reducing the PAPRs of their time-domain counterpart signals. Meanwhile, the additive perturbation signal associated with each tone is constrained to lie in the null-space of its associated channel matrix, such that it does not cause any multi-user inference or out-of-band radiations. Such a problem is formulated as a convex optimization problem, and an efficient algorithm is developed by resorting to the variable splitting and alterative direction method of multipliers (ADMM) techniques. Simulation results show that the proposed method has a fast convergence rate and achieves substantial PAPR reduction within only tens of iterations. In addition, unlike other precoding-based PAPR reduction methods, our proposed method which introduces perturbation signals to the precoded signals is independent of the precoding stage and thus could be more suitable for practical systems.
Preparation of Asialoorosomucoid-Polylysine Conjugates (1994)

Asialoorosomucoid-polylysine (ASOR-PL) conjugates have been recently developed as carriers of electrostatically bound DNA for targeted delivery to the hepatic asialoglycoprotein receptor (ASGPr) for gene therapy. Using acid-urea gel electrophoresis we have found that previously reported procedures for the fractionation of ASOR-PL conjugates do not efficiently remove noncovalently bound polylysine (PL) from ASOR-PL. DNA complexes prepared with these conjugates have low solubilities, which limits their usefulness for subsequent experimentation, particularly in vivo. For ASOR-PL made by carbodiimide-mediated crosslinking with 5-kDa PL, dialysis against 1 M guanidine hydrochloride is effective to remove the low molecular weight unbound PL. Dialysis is not feasible when using higher molecular weight PLs, but preparative elution acid-urea gel electrophoresis was used to isolate crude ASOR-PL fractions free of unbound PL. ASOR-PL freed of PL by dialysis or electrophoresis was further fractionated by cation-exchange HPLC on carboxymethyl-functionalized columns eluted with a mixed pH-salt gradient. Early-eluting ASOR-PL fractions isolated by a combination of preparative elution acid-urea gel electrophoresis and cation-exchange HPLC were found to be preferred for the formation of soluble DNA complexes.
On the origins of RF-based location (2011)

This paper will provide a brief survey of the origins of RF-based location technology through the beginning of the Second World War. Direction finding (DF) was invented by John Stone Stone in 1902 and improved upon by Lee de Forest, Ettore Bellini and Alessandro Tosi. Both radar and amplitude ranging date to 1904, although these concepts were in advance of the ability of RF technology to implement. DF played a critical role in the First World War, most notably in the naval Battle of Jutland. The requirement for accurate night-time direction led classicist and cryptographer Frank Adcock to invent an improved DF system. In the 1920's, DF and related concepts came of age for civilian applications like navigation. Inventors of the period introduced a variety of other techniques were introduced including time-of-flight or transponder ranging. By the time of the Second World War, DF was a mature field and additional novel RF-based technologies were ready to be developed.
Effects of Stent Design Parameters on Normal Artery Wall Mechanics (2006)

A stent is a device designed to restore flow through constricted arteries. These tubular scaffold devices are delivered to the afflicted region and deployed using minimally invasive techniques. Stents must have sufficient radial strength to prop the diseased artery open. The presence of a stent can subject the artery to abnormally high stresses that can trigger adverse biologic responses culminating in restenosis. The primary aim of this investigation was to investigate the effects of varying stent "design parameters" on the stress field induced in the normal artery wall and the radial displacement achieved by the stent. The generic stent models were designed to represent a sample of the attributes incorporated in present commercially available stents. Each stent was deployed in a homogeneous, nonlinear hyperelastic artery model and evaluated using commercially available finite element analysis software. Of the designs investigated herein, those employing large axial strut spacing, blunted corners, and higher amplitudes in the ring segments induced high circumferential stresses over smaller areas of the artery's inner surface than all other configurations. Axial strut spacing was the dominant parameter in this study, i.e., all designs employing a small stent strut spacing induced higher stresses over larger areas than designs employing the large strut spacing. Increasing either radius of curvature or strut amplitude generally resulted in smaller areas exposed to high stresses. At larger strut spacing, sensitivity to radius of curvature was increased in comparison to the small strut spacing. With the larger strut spacing designs, the effects of varying amplitude could be offset by varying the radius of curvature and vice versa. The range of minimum radial displacements from the unstented diastolic radius observed among all designs was less than 90 microm. Evidence presented herein suggests that stent designs incorporating large axial strut spacing, blunted corners at bends, and higher amplitudes exposed smaller regions of the artery to high stresses, while maintaining a radial displacement that should be sufficient to restore adequate flow.
TREM-1–expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases (2007)

Triggering receptor expressed on myeloid cells-1 (TREM-1) potently amplifies acute inflammatory responses by enhancing degranulation and secretion of proinflammatory mediators. Here we demonstrate that TREM-1 is also crucially involved in chronic inflammatory bowel diseases (IBD). Myeloid cells of the normal intestine generally lack TREM-1 expression. In experimental mouse models of colitis and in patients with IBD, however, TREM-1 expression in the intestine was upregulated and correlated with disease activity. TREM-1 significantly enhanced the secretion of relevant proinflammatory mediators in intestinal macrophages from IBD patients. Blocking TREM-1 by the administration of an antagonistic peptide substantially attenuated clinical course and histopathological alterations in experimental mouse models of colitis. This effect was also seen when the antagonistic peptide was administered only after the first appearance of clinical signs of colitis. Hence, TREM-1-mediated amplification of inflammation contributes not only to the exacerbation of acute inflammatory disorders but also to the perpetuation of chronic inflammatory disorders. Furthermore, interfering with TREM-1 engagement leads to the simultaneous reduction of production and secretion of a variety of pro-inflammatory mediators such as TNF, IL-6, IL-8 (CXCL8), MCP-1 (CCL2), and IL-1beta. Therefore, TREM-1 may also represent an attractive target for the treatment of chronic inflammatory disorders.
Predicting U.S. Recessions with Dynamic Binary Response Models (2008)

We develop dynamic binary probit models and apply them for predicting U.S. recessions using the interest rate spread as the driving predictor. The new models use lags of the binary response (a recession dummy) to forecast its future values and allow for the potential forecast power of lags of the underlying conditional probability. We show how multiperiod-ahead forecasts are computed iteratively using the same one-period-ahead model. Iterated forecasts that apply specific lags supported by statistical model selection procedures turn out to be more accurate than previously used direct forecasts based on horizon-specific model specifications.
O-acetylated gangliosides in bovine buttermilk. Characterization of 7-O-acetyl, 9-O-acetyl, and 7,9-di-O-acetyl GD3. (1992)

Three O-acetylated gangliosides, G1, G2, and G3, were purified from bovine buttermilk by using chloroform/methanol extraction, Folch partitioning, chromatography on DEAE-Sephadex A-25, and Iatrobeads columns. The final yields of gangliosides G1, G2, and G3 were 2 mg, 37 mg, and 40 mg per 1.7 kg of the buttermilk powder, respectively. On the basis of immunostaining on high performance thin layer chromatography with specific monoclonal antibodies, mild alkaline treatment, gas-liquid chromatographic analysis, fast atom bombardment mass spectrometry, and proton nuclear magnetic resonance studies, G1 and G2 are characterized as O-acetylated GD3 and G3 as O-acetylated GT3, and the structures of these gangliosides are as follows: [formula: see text] The major fatty acids of these gangliosides were C18:0, C22:0, C23:0, and C24:0, and the long chain base was C18-sphingosine.
Steady State Analysis of Nonlinear Circuits That Have a Periodic Response (1971)

Abstract : A very important problem is the computer-aided design of nonlinear circuits is the steady state analysis of lightly damped nonlinear circuits such as harmonic multipliers and oscillators. Presently one searches for the periodic response by simply integrating the system equations from a given initial state until the response becomes periodic. In lightly damped systems this integration could extend over many periods making the computation costly. In this paper a Newton algorithm is defined which converges rapidly to the steady state response. The algorithm is applied to several nonlinear circuits. The results show a considerable reduction in the amount of time necessary to compute the steady state response. In addition, the initial iterates give information on the transient response of the system. (Author) mation on the transient response of the system. (Author)