gebhart/patrepeval huggingface dataset:
A simplified process flow for silicon heterojunction interdigitated back contact solar cells: Using shadow masks and tunnel junctions (2014)

A novel process flow, which can allow the formation of interdigitated p- and n-type a-Si strips and corresponding transparent conductive oxide (TCO) and metal layers for silicon heterojunction interdigitated back contact (SHJ-IBC) solar cells using only a single alignment step and without using any resist patterning is presented. The flow is based on the deposition of a-Si, TCO and metal layers through a stack of shadow masks. Three variation of the flow are described. Several key process components to include a-Si deposition and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> plasma etch through the shadow mask are demonstrated and described.
Fluoxetine in the Treatment of Premenstrual Dysphoria (1995)

Fluoxetine is useful in the treatment of premenstrual dysphoria. Treatment with fluoxetine at a dose of 20 mg per day reduces the potential for side effects while maximizing therapeutic efficacy.
Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis (2002)

This study has demonstrated that PSCs have the capacity to respond to cytokines known to be upregulated during acute pancreatitis. Persistent activation of PSCs by cytokines during acute pancreatitis may be a factor involved in the progression from acute pancreatitis to chronic pancreatic injury and fibrosis.
Lipopolysaccharide Binding Protein and Serum Amyloid A Secretion by Human Intestinal Epithelial Cells During the Acute Phase Response (1999)

The acute phase proteins LPS binding protein (LBP) and serum amyloid A (SAA) are produced by the liver and are present in the circulation. Both proteins have been shown to participate in the immune response to endotoxins. The intestinal mucosa forms a large surface that is continuously exposed to these microbial products. By secretion of antimicrobial and immunomodulating agents, the intestinal epithelium contributes to the defense against bacteria and their products. The aim of this study was to explore the influence of the inflammatory mediators TNF-alpha, IL-6, and IL-1beta on the release of LBP and SAA by intestinal epithelial cells (IEC). In addition, the induction of LBP and SAA release by cell lines of intestinal epithelial cells and hepatic cells was compared. The data obtained show that in addition to liver cells, IEC also expressed LBP mRNA and released bioactive LBP and SAA upon stimulation. Regulation of LBP and SAA release by IEC and hepatocytes was typical for class 1 acute phase proteins, although differences in regulation between the cell types were observed. Endotoxin did not induce LBP and SAA release. Glucocorticoids were demonstrated to strongly enhance the cytokine-induced release of LBP and SAA by IEC, corresponding to hepatocytes. The data from this study, which imply that human IEC can produce LBP and SAA, suggest a role for these proteins in the local defense mechanism of the gut to endotoxin. Furthermore, the results demonstrate that tissues other than the liver are involved in the acute phase response.
A Newly Identified Bocavirus Species in Human Stool (2008)

Viral metagenomic analysis was used to identify a previously uncharacterized parvovirus species, "HBoV2," whose closest phylogenetic relative is the human bocavirus (HBoV). HBoV2 has a genomic organization identical to that of HBoV but has only 78%, 67%, and 80% identity, respectively, with the latter's NS1, NP1, and VP1/VP2 proteins. The study used polymerase chain reaction to detect HBoV2 sequences in 5 of 98 stool samples from Pakistani children and in 3 of 699 stool samples from Edinburgh. Nearly-full-length genome sequencing revealed the presence of 3 HBoV2 genotypes and evidence of recombination between genotypes. Further studies are necessary to identify anatomical sites of HBoV2 replication and potential associations with clinical symptoms or disease.
Plasma Incretin Levels and Dipeptidyl Peptidase-4 Activity in Patients with Obstructive Sleep Apnea (2016)

OSA is associated with elevated serum levels of the incretin hormones GLP-1 (fasting) and GIP (post-prandial) in patients without diabetes. A significant association between body mass index and DPP-4, which is said to exist in healthy persons, was not found in the patients with OSA. Fasting GLP-1 in patients without diabetes with OSA may influence fasting glucose levels.
Roles of glutamate transporters in shaping excitatory synaptic currents in cerebellar Purkinje cells (2004)

Several subtypes of glutamate transporters are abundantly expressed near the excitatory synapses on cerebellar Purkinje cells. We investigated the roles of the glutamate transporters in shaping the excitatory postsynaptic currents (EPSCs) and regulating the levels of extracellular glutamate in the mouse cerebellum using a potent blocker of glutamate transporters, dl-threo-beta-benzyloxyaspartate (dl-TBOA). This drug markedly prolonged AMPA receptor-mediated EPSCs in Purkinje cells evoked by stimulating both parallel fibres and climbing fibres. The decay phase of the prolonged EPSCs was fitted by double exponentials, of which the slower component was preferentially inhibited by a low-affinity competitive antagonist of AMPA receptors, gamma-d-glutamyl-glycine, indicating that the slow component induced by dl-TBOA was the AMPA receptor-mediated current activated by lower concentrations of glutamate than those contributing to the peak of the EPSC. This result suggests that dl-TBOA prolongs the stay of synaptically released glutamate in the synaptic cleft and also induces glutamate spillover to extrasynaptic targets as well as neighbouring synapses. Furthermore, high concentrations of dl-TBOA in the presence of cyclothiazide generated a continuous inward current in Purkinje cells, of which the amplitude reached the peak level of the climbing-fibre EPSC. This continuous inward current was abolished by the blocker of AMPA receptors, indicating that the strong inhibition of glutamate uptake causes the rapid accumulation of glutamate in the extracellular space. These results highlight the importance of glutamate transporters in maintaining the proper glutamatergic transmission in Purkinje cell synapses.
Strict a priori constraints for maximum-likelihood blind deconvolution (1995)

We present a maximum-likelihood approach to improve blind deconvolution of an image. Blind deconvolution is performed through the minimization of an error function by use of the conjugate gradient method, as suggested by Lane [ J. Opt. Soc. Am. A9, 1508 ( 1992)]. We show how to implement strict constraints, such as image positivity, using a reparameterization. As an example, the point-spread function can be described by phase aberrations in the case of speckle imaging. The improvement brought by the use of strict rather than loose constraints is demonstrated on both simulated and real data. Different noise levels and object types are considered.
New Insights Into the Progression of Aortic Stenosis (2000)

Absolute and percentage reduction in AVA per year in those with AS is greater in those with milder degrees of stenosis and is accelerated in the presence of smoking, hypercholesterolemia, and elevated serum creatinine and calcium levels. These findings may have important implications in gaining further insights into the mechanism of AS progression and in formulating strategies to retard this process.
Performance Comparison of MPI Implementations over InfiniBand, Myrinet and Quadrics (2003)

In this paper, we present a comprehensive performance comparison of MPI implementations over Infini-Band, Myrinet and Quadrics. Our performance evaluation consists of two major parts. The first part consists of a set of MPI level micro-benchmarks that characterize different aspects of MPI implementations. The second part of the performance evaluation consists of application level benchmarks. We have used the NAS Parallel Benchmarks and the sweep3D benchmark. We not only present the overall performance results, but also relate application communication characteristics to the information we acquired from the micro-benchmarks. Our results show that the three MPI implementations all have their advantages and disadvantages. For our 8-node cluster, InfiniBand can offer significant performance improvements for a number of applications compared with Myrinet and Quadrics when using the PCI-X bus. Even with just the PCI bus, InfiniBand can still perform better if the applications are bandwidth-bound.
Scission of Diblock Copolymers into Their Constituent Blocks (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTScission of Diblock Copolymers into Their Constituent BlocksSerkan Yurt, Uche K. Anyanwu, Jocelyn R. Scheintaub, E. Bryan Coughlin, and D. VenkataramanView Author Information Department of Chemistry and Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003 Cite this: Macromolecules 2006, 39, 5, 1670–1672Publication Date (Web):February 2, 2006Publication History Received29 November 2005Revised10 January 2006Published online2 February 2006Published inissue 1 March 2006https://pubs.acs.org/doi/10.1021/ma052549uhttps://doi.org/10.1021/ma052549urapid-communicationACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views930Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Copolymers,Ethers,Gel permeation chromatography,Polymers Get e-Alerts
Has Oxygen Administration Delayed Appropriate Respiratory Care? Fallacies Regarding Oxygen Therapy (2003)

Modern clinical use of supplemental oxygen supposes that: (1) exposure to F(IO)(2) < or = 60% is without adverse effects, (2) an individual at risk of developing arterial hypoxemia can be protected by administering high F(IO)(2), and (3) routine administration of supplemental oxygen is useful, harmless, and clinically indicated. There is now substantial evidence that none of those 3 suppositions are correct, and, on the contrary, supplemental oxygen is actually detrimental to many of the patients who receive it. Supplemental oxygen is much overused and its use should be limited to the few conditions and situations in which it is truly effective, useful, and non-detrimental.
Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry. (1976)

High sensitivity differential scanning calorimetry is applied to the study of the thermotropic behavior of mixtures of synthetic phospholipids in multilamellar aqueous suspensions. The systems dimyristoylphosphatidylcholine dipalmitoylphosphatidylcholine, and dimyristoylphosphatidylethanolamine-distearoylphosphatidylcholine, although definitely nonideal, exhibit essentially complete miscibility in both gel and liquid crystalline states, while the system dilauroylphosphatidylcholine-distearoylphosphatidylcholine is monotectic with lateral phase separation in the gel state. Comparison of the observed transition curves with theoretical curves calculated from the calorimetrically determined phase diagrams supports a literal interpretation of the phase diagrams.
Predominant expression of invariant Vα14+ TCR α chain in NK1.1+ T cell populations (1995)

A novel T cell subset characterized by cell surface NK1.1+ TCR alpha beta+ expression was investigated for its TCR alpha usage, particularly that of invariant V alpha 14 TCR, which was found to be preferentially used in peripheral CD4-CD8- T cells developed at extrathymic sites. We found that NK+ alpha beta T cell subsets account for 0.4% in thymocytes, 5% in the splenic T cells and 40.5% in the bone marrow T cells. Among these NK+ alpha beta T cells, two distinct subsets were detected; cell surface TCR V alpha 14+ and V alpha 14- subpopulations. Almost all of NK+ alpha beta thymocytes express V alpha 14 mRNA; however, only < 20% were positive, while > 80% were negative or undetectable for V alpha 14 TCR expression on the cell surface in the thymus. Similarly, approximately 50% of NK+ alpha beta T cells in spleen and bone marrow are V alpha 14+ as revealed by FACS. TCR repertoire analysis by nucleotide sequences on inverse PCR products demonstrated that most NK+ alpha beta T cells express an invariant TCR encoded by the V alpha 14J alpha 281 gene with a 1 base N-region in all tissues. Thus, invariant V alpha 14 TCR is uniquely expressed on NK T cells, and can be a marker to distinguish NK, NK T and T cells.
Software framework of a real-time pre-beamformed RF data acquisition of an ultrasound research scanner (2012)

Acquisition of pre-beamformed data is essential in advanced imaging research studies such as adaptive beamforming, synthetic aperture imaging, and photoacoustic imaging. Ultrasonix Co. has developed such a data acquisition device for pre-beamformed data known as the SONIX-DAQ, but data can only be downloaded and processed offline rather than streamed in real-time. In this work, we developed a software framework to extend the functionality of the SONIX-DAQ for streaming and processing data in near real-time. As an example, we applied this functionality to our previous work of visualizing photoacoustic images of prostate brachytherapy seeds. In this paper, we present our software framework, applying it to a real-time photoacoustic imaging system, including real-time data collection and data-processing software modules for brachytherapy treatment.
Silk fibroin-polyurethane scaffolds for tissue engineering (2003)

Silk ribroin (SF)-based or -coated biomaterials are likely to be endowed with properties fitting tissue engineering applications. In this work we investigated the interactions between SF-coated polyurethane (PU) membranes and foams, and four different strains of normal human adult fibroblasts (HAF). In parallel, the same cell strains were grown on polystyrene plates and uncoated PU scaffolds. With respect to the uncoated homologues, cell adhesion to SF-coated PU membranes was two-fold within 3 h and cell numbers were 2.5-fold higher after 30 days in culture; SF-coated PU foams were found to harbor 1.39-fold more cells after 30 days in vitro (p < 0.01). This enhanced cell growth was coupled with a more intense uptake of glucose and a higher secretion rate of lactate, but with similar consumption of glutamine. In addition, cells on SF-coated membranes exhibited a higher secretion rate of interleukin-6. HAF cultured on all types of substrates were never found to secrete any ELISA-assayable amount of the main pro-inflammatory cytokines IL-1/spl beta/, TNF-/spl alpha/, and TGF-/spl beta/1. The rate of the extracellular assembly of collagen type I fibers, measured by the release of procollagen C-peptide, was found to be somewhat higher on both 2D and 3D SF-coated PU scaffolds. On the whole, these results show that SF-coated PU substrates constitute a novel type of composite biomaterial that promotes cell adhesion and growth, and the performance of specific metabolic tasks of normal HAF without inducing any secretion of some of the most relevant proinflammatory cytokines.
Study of insertion task of a flexible beam into a hole (2002)

Discusses the task of inserting a flexible beam into a hole when the friction force is large enough to buckle the beam. The authors analyze the buckle shape of the beam and external forces and moments loaded on the beam during the insertion task, under the condition that the potential energy of the beam is minimized. Then, the authors find that the buckling shape has two buckling modes and the modes are changed by varying the orientation angle of the end of the beam. The authors propose a method of performing the insertion task, based on an analysis of the relation between the external forces and friction coefficient. Finally, the authors present experimental results which confirm their analysis.
Robust digit recognition in noisy environments: the IBM Aurora 2 system (2001)

ABSTRACTIn this paper we describe some experiments on the Aurora 2 noisydigits database. The algorithms that we used can be broadly clas-siﬁed into noise robustness techniques based on a linear-channelmodel of the acoustic environment such as CDCN [1] and its novelvariant termed Alignment-based CDCN( ACDCN , proposed here),and techniques which do not assume any particular knowledgeabout thestructure of the environment or noise conditions affectingthe speech signal such as discriminant feature space transforma-tions and speaker/channel adaptation. We present recognition ex-periments for both the clean training data and the multi-conditiontraining data scenarios.1. INTRODUCTIONIn this paper we describe the system and techniques for the Aurora2 noisy digits database and the results obtained. We developed twosets of acoustic models: the ﬁrst set of models was trained on cleandata only and the second set was trained on the multi-conditiontraining data. For the system trained on clean data only, we appliedCDCN [1] and a novel variant of this technique called Alignment-based CDCN (
Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis (2011)

Candida albicans supernatants contain a mixture of autoregulatory alcohols. In vitro, when added individually or in combination, these alcohols inhibit the yeast to filamentous form conversion. Here we evaluate the in vivo effect of the exogenous administration of a Cocktail solution simulating the composition of alcohols present in a C. albicans culture supernatant (1 ml; 94 μmol l(-1) isoamyl alcohol, 70 μmol l(-1) 2-phenylethanol, 3.2 n mol l(-1) E -nerolidol, and 18 n mol l(-1) E,E -farnesol) using the well established murine model of hematogenously disseminated candidiasis. Mice injected intraperitoneally with the Cocktail solution demonstrated increased survival and decreased organ fungal burden compared to control mice. Histological observations suggest that the Cocktail, to some extent, has an inhibitory effect on cell filamentation within the kidney. These findings suggest that the exogenous administration of C. albicans autoregulatory alcohols displays a protective effect during disseminated candidiasis.
Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques (2007)

Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses are critical in the early control and resolution of HIV infection and correlate with postchallenge outcomes in rhesus macaque challenge experiments, we sought to identify a plasmid DNA (pDNA) vaccine design capable of eliciting robust and balanced CMI responses to multiple HIV type 1 (HIV-1)-derived antigens for further development. Previously, a number of two-, three-, and four-vector pDNA vaccine designs were identified as capable of eliciting HIV-1 antigen-specific CMI responses in mice (M. A. Egan et al., Vaccine 24:4510-4523, 2006). We then sought to further characterize the relative immunogenicities of these two-, three-, and four-vector pDNA vaccine designs in nonhuman primates and to determine the extent to which in vivo electroporation (EP) could improve the resulting immune responses. The results indicated that a two-vector pDNA vaccine design elicited the most robust and balanced CMI response. In addition, vaccination in combination with in vivo EP led to a more rapid onset and enhanced vaccine-specific immune responses. In macaques immunized in combination with in vivo EP, we observed a 10- to 40-fold increase in HIV-specific enzyme-linked immunospot assay responses compared to those for macaques receiving a 5-fold higher dose of vaccine without in vivo EP. This increase in CMI responses translates to an apparent 50- to 200-fold increase in pDNA vaccine potency. Importantly, in vivo EP enhanced the immune response against the less immunogenic antigens, resulting in a more balanced immune response. In addition, in vivo EP resulted in an approximate 2.5-log(10) increase in antibody responses. The results further indicated that in vivo EP was associated with a significant reduction in pDNA persistence and did not result in an increase in pDNA associated with high-molecular-weight DNA relative to macaques receiving the pDNA without EP. Collectively, these results have important implications for the design and development of an efficacious vaccine for the prevention of HIV-1 infection.
Association of polymorphisms -1154G/A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women (2009)

The VEGF-460/-1154/-2578 TGC, CAA, TAA and TAC haplotypes were associated with endometriosis. The -1154A and -2578A alleles may be protective against the development of endometriosis in North Chinese women.
In vitro predictors of therapeutic response in melanoma patients receiving tumor-infiltrating lymphocytes and interleukin-2. (1994)

The associations of TIL lysis of autologous tumor and younger TIL age with clinical response observed in this study are supportive of previous reports, and these findings will be useful in designing future clinical trials. The new observation correlating GM-CSF secretion by TIL with clinical response is interesting and needs further substantiation.
Vasopressin and vascular reactivity in the development of DOCA hypertension in rats with hereditary diabetes insipidus. (1982)

To examine the role of vasopressin (VP) in DOCA-salt hypertension, arterial pressure and renal vascular reactivity were studied in control Long-Evans (LE) rats and in Brattleboro rats homozygous for diabetes insipidus (DI rats). Vascular reactivity to norepinephrine, VP and angiotensin II was assessed in isolated kidneys perfused at constant flow. LE rats showed an increase in arterial pressure (AP) which was significant at 2 weeks post DOCA and averaged 180 mm Hg at 4 weeks. DI rats lacking VP showed no rise in AP after DOCA; however, DI rats given VP and DOCA developed hypertension with a course and magnitude similar to that observed in LE rats. At 6 to 10 weeks post DOCA, renal vascular reactivity to all agents was increased in LE rats and DI rats replaced with VP. Normotensive DI rats lacking VP showed depressed reactivity. Assessment of changes in reactivity at 3 days post DOCA showed that changes preceded the rise in AP. These data suggest that VP may play a primary role in the pathogenesis of DOCA hypertension and that its mechanism may involve an induction of increased vascular reactivity.