gebhart/patrepeval huggingface dataset:
Imprinting of Molecular Recognition Sites on Nanostructures and Its Applications in Chemosensors (2008)

Biological receptors including enzymes, antibodies and active proteins have been widely used as the detection platform in a variety of chemo/biosensors and bioassays. However, the use of artificial host materials in chemical/biological detections has become increasingly attractive, because the synthetic recognition systems such as molecularly imprinted polymers (MIPs) usually have lower costs, higher physical/chemical stability, easier preparation and better engineering possibility than biological receptors. Molecular imprinting is one of the most efficient strategies to offer a synthetic route to artificial recognition systems by a template polymerization technique, and has attracted considerable efforts due to its importance in separation, chemo/biosensors, catalysis and biomedicine. Despite the fact that MIPs have molecular recognition ability similar to that of biological receptors, traditional bulky MIP materials usually exhibit a low binding capacity and slow binding kinetics to the target species. Moreover, the MIP materials lack the signal-output response to analyte binding events when used as recognition elements in chemo/biosensors or bioassays. Recently, various explorations have demonstrated that molecular imprinting nanotechniques may provide a potential solution to these difficulties. Many successful examples of the development of MIP-based sensors have also been reported during the past several decades. This review will begin with a brief introduction to the principle of molecular imprinting nanotechnology, and then mainly summarize various synthesis methodologies and recognition properties of MIP nanomaterials and their applications in MIP-based chemosensors. Finally, the future perspectives and efforts in MIP nanomaterials and MIP-based sensors are given.
A signal subspace tracking algorithm for microphone array processing of speech (1997)

This paper presents a method of adaptive microphone array beamforming using matched filters with signal subspace tracking. Our objective is to enhance near-field speech signals by reducing multipath and reverberation. In real applications such as speech acquisition in acoustic environments, sources do not propagate along known and direct paths. Particularly in hands-free telephony, we have to deal with undesired propagation phenomena such as reflections and reverberation. Prior methods developed adaptive microphone arrays for noise reduction after a time delay compensation of the direct path. This simple synchronization is insufficient to produce an acceptable speech quality, and makes adaptive beamforming unsuitable. We prove the identification of source-to-array impulse responses to be possible by subspace tracking. We consequently show the advantage of treating synchronization as a matched filtering step. Speech quality is indeed enhanced at the output by the suppression of reflections and reverberation (i.e., dereverberation), and efficient adaptive beamforming for noise reduction is applied without risk of signal cancellation. Evaluations confirm the performance achieved by the proposed algorithm under real conditions.
Apoptosis: a different type of cell death (1992)

Apoptosis is a type of cell death that plays an important role in early development and growth of normal adult tissues. It is regulated by physiological stimuli and is present in many species and tissues. The main morphological characteristics are nuclear fragmentation and cellular breakdown in apoptotic vesicles. Internucleosomal DNA fragmentation is an important biochemical feature that is the result of a yet to be isolated endonuclease activity. Experiments using RNA and protein synthesis inhibitors suggest the presence of either intracellular repressors or inducers of apoptosis.
Epipolar Constraints for Vision-Aided Inertial Navigation (2005)

This paper describes a new method to improve inertial navigation using feature-based constraints from one or more video cameras. The proposed method lengthens the period of time during which a human or vehicle can navigate in GPS-deprived environments. Our approach integrates well with existing navigation systems, because we invoke general sensor models that represent a wide range of available hardware. The inertial model includes errors in bias, scale, and random walk. Any purely projective camera and tracking algorithm may be used, as long as the tracking output can be expressed as ray vectors extending from known locations on the sensor body. A modified linear Kalman filter performs the data fusion. Unlike traditional SLAM, our state vector contains only inertial sensor errors related to position. This choice allows uncertainty to be properly represented by a covariance matrix. We do not augment the state with feature coordinates. Instead, image data contributes stochastic epipolar constraints over a broad baseline in time and space, resulting in improved observability of the IMU error states. The constraints lead to a relative residual and associated relative covariance, defined partly by the state history. Navigation results are presented using high-quality synthetic data and real fisheye imagery.
BH3 domains as BCL-2 inhibitors: prototype cancer therapeutics (2003)

It is likely that most, if not all, cancer cells possess a mechanism for opposing programmed cell death, or apoptosis. One mechanism often used by cancer cells to escape apoptosis is the overexpression of B cell leukaemia/lymphoma-2 protein (BCL-2) or related antiapoptotic proteins. Inhibiting BCL-2, therefore, is an anticancer strategy worthy of attention. BCL-2 homology 3 (BH3) domains are α-helical segments found in BCL-2 family member proteins. In pro-apoptotic members, the BH3 domain is necessary for pro-apoptotic function. It has been shown that short peptides derived from the BH3 region possess intrinsic pro-death activity. Furthermore, certain peptides of this group exert their pro-death function by specifically binding BCL-2 and opposing BCL-2’s antideath function. Therefore, BH3 domains are prototype BCL-2 inhibitors. Mimetics of BH3 domains, whether derived from peptides or small molecules, have promise as cancer therapeutics.
Rerouting for handoff in a wireless ATM network (1996)

Handoff is the procedure by which a user's radio link is transferred between radio ports in the network without an interruption of the user connection. We discuss how a wireless asynchronous transfer mode (ATM) network may reroute a user connection during a handoff. The authors propose a novel procedure called "nearest common node rerouting (NCNR)". NCNR is designed to perform the rerouting of user connections due to a handoff event in a fast and efficient manner. The authors conclude by comparing NCNR to other rerouting schemes discussed in the literature.
Taste Masking Technologies in Oral Pharmaceuticals: Recent Developments and Approaches (2004)

Taste is one of the most important parameters governing patient compliance. Undesirable taste is one of several important formulation problems that are encountered with certain drugs. Oral administration of bitter drugs with an acceptable degree of palatability is a key issue for health care providers, especially for pediatric patients. Several oral pharmaceuticals, numerous food and beverage products, and bulking agents have unpleasant, bitter-tasting components. So, any pharmaceutical formulation with a pleasing taste would definitely be preferred over a competitor's product and would translate into better compliance and therapeutic value for the patient and more business and profits for the company. The desire of improved palatability in these products has prompted the development of numerous formulations with improved performance and acceptability. This article reviews the earlier applications and methodologies of taste masking and discusses the most recent developments and approaches of bitterness reduction and inhibition for oral pharmaceuticals.
Variable frequency field conjugate lenses for ultrasound hyperthermia (1995)

This paper describes variable frequency focusing with field conjugate lenses designed to mimic the multiple-focusing capabilities of large two-dimensional phased arrays. Simulations, experiments, and Fresnel diffraction analysis are used to show that both the size and the depth of a field conjugate lens focus may vary with frequency. Examples are given for field conjugate lens focusing with planar transducers, focused transducers, and ordinary refracting lenses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expression of the Escherichia coli pntA and pntB Genes, Encoding Nicotinamide Nucleotide Transhydrogenase, in Saccharomyces cerevisiae and Its Effect on Product Formation during Anaerobic Glucose Fermentation (1999)

We studied the physiological effect of the interconversion between the NAD(H) and NADP(H) coenzyme systems in recombinant Saccharomyces cerevisiae expressing the membrane-bound transhydrogenase from Escherichia coli. Our objective was to determine if the membrane-bound transhydrogenase could work in reoxidation of NADH to NAD+ in S. cerevisiae and thereby reduce glycerol formation during anaerobic fermentation. Membranes isolated from the recombinant strains exhibited reduction of 3-acetylpyridine-NAD+ by NADPH and by NADH in the presence of NADP+, which demonstrated that an active enzyme was present. Unlike the situation in E. coli, however, most of the transhydrogenase activity was not present in the yeast plasma membrane; rather, the enzyme appeared to remain localized in the membrane of the endoplasmic reticulum. During anaerobic glucose fermentation we observed an increase in the formation of 2-oxoglutarate, glycerol, and acetic acid in a strain expressing a high level of transhydrogenase, which indicated that increased NADPH consumption and NADH production occurred. The intracellular concentrations of NADH, NAD+, NADPH, and NADP+ were measured in cells expressing transhydrogenase. The reduction of the NADPH pool indicated that the transhydrogenase transferred reducing equivalents from NADPH to NAD+.
Characterization of balsa wood mechanical properties required for continuum damage mechanics analysis (2014)

Balsa wood has attained commercial importance because of its exceptional lightweight and its insulating properties. The use of balsa as core material in sandwich construction for aircraft and for other lightweight structures has greatly increased the use of this unique material. In the present study, the mechanical properties of balsa wood required for the continuum damage mechanics analysis are calculated using experimental, analytical, and numerical results. Extensive experiments are carried out that evaluate the tension, compression, and shear properties. Equivalent modulus has been calculated from the bi-modulus behavior of balsa wood obtained from the experiments. The properties that could not be obtained from the experiments were calculated using analytical solutions. The mechanical properties obtained were compared with the results available in literature and the numerical solutions using LS-DYNA. Finally, the mechanical properties are calibrated using GENOA—a commercial software based on the wood cell constituent properties and experimental results.
Nanoscale Spatial Heterogeneity in Deep Eutectic Solvents (2016)

In this article, we report a molecular dynamics simulation study on the X-ray and neutron scattering structures of deep eutectic solvents (DESs) and show that the DESs studied possess unique spatial heterogeneity on molecular length scales. The simulated X-ray and neutron scattering structure functions (S(q)s) of the DESs made of alkylamide + Li(+)/ClO4(-) display two peaks in the intermolecular region of the S(q)s. As a signature of nanoscale structural organization/heterogeneity, a prepeak is observed at 0.1 < q/Å(-1) < 0.4. The principal peak observed at around 1.2 < q/Å(-1) < 2 is rendered by short-distance inter- and intraspecies correlations. For the DESs studied, we demonstrate that nanoscale spatial heterogeneity is exhibited profoundly by the segregated domains of the constituent electrolyte, and the principal peak in S(q) is because of all sorts of close-contact correlations. The extent of nanoscale morphology as well as the strength of ion pairing is enhanced for the longer-tail alkylamide DES.
Preparation of Designer Resins via Living Free Radical Polymerization of Functional Monomers on Solid Support (1999)

Merrifield resin is converted to a solid-supported free radical initiator by reacting with the TEMPO-Na. Heating TEMPO-methyl resin with a variety of functionalized styrene and acrylate monomers gives larger resin beads via living free radical polymerization. We have coined the term Rasta resin to describe resin beads prepared in this fashion. The process can be described as a solvent-free suspension polymerization. It is particularly well suited for preparation of resin beads from monomers which contain electrophilic groups that would be destroyed upon suspension polymerization in water. Rasta resins have a novel macromolecular architecture wherein long straight chain polymers bearing reactive functional groups emanate from the phenyl groups of a cross-linked polystyrene core. With judicious choice of co-monomers and polymerization strategy, the solvent affinity, loading capacity, and distance of functionality from the cross-linked core may be controlled giving beads with properties that are tailored to specific uses as synthesis supports and scavenging resins.
Efficiency of a Pneumococcal Opsonophagocytic Killing Assay Improved by Multiplexing and by Coloring Colonies (2003)

For evaluating pneumococcal vaccines, the opsonophagocytic killing assay (OPKA) is useful as a supplement to the pneumococcal antibody enzyme-linked immunosorbent assay (ELISA). However, evaluations of pneumococcal vaccines require the determination of antibody responses to 7 to 11 serotypes, and the OPKA is tedious to perform and requires more serum than the ELISA. Consequently, the OPKA is infrequently used for evaluating pneumococcal vaccines. To overcome these limitations, we have developed a simple multiplexed (double-serotype) OPKA by using antibiotic-resistant pneumococci for nine serotypes. Serotype 6B, 9V, 19A, and 23F strains were made streptomycin resistant, and serotype 4, 6A, 14, 18C, and 19F strains were made optochin resistant. The multiplexed OPKA was the same as the single-serotype OPKA except for two changes. First, the target bacteria were a mixture of one streptomycin-resistant strain and one optochin-resistant strain. Second, the surviving bacteria of each serotype were enumerated by plating on Todd-Hewitt agar plates with yeast extract and an agar overlay containing the appropriate antibiotics and 2,3,5-triphenyl tetrazolium chloride. The performance of the multiplexed OPKA was evaluated by analyzing 28 serum samples from adults immunized with a 23-valent polysaccharide vaccine by using the single-serotype OPKA and the multiplexed OPKA. The multiplexed OPKA was specific for the desired serotypes. The multiplexed and conventional OPKAs had comparable assay sensitivities and produced results that were highly correlated (r(2) values ranging from 0.92 to 0.98) for all nine serotypes. A simple modification of the conventional OPKA produces a multiplexed assay that greatly reduces effort, reagents, and the necessary amount of serum.
Universal bases for hybridization, replication and chain termination (2000)

Several unnatural, predominantly hydrophobic nucleobases that pack efficiently in duplex DNA without hydrogen bonding functionalities are reported to circumvent the hydrogen bonding-based specificity, both during oligonucleotide hybridization and enzymatic DNA synthesis. The reported nucleoside analogs are efficient 'universal bases' for hybridization, template directed DNA synthesis and chain termination. Moreover, several of the universal bases function in their biological role, hybridization or replication, with an efficiency not significantly reduced relative to their natural counterparts.
Synthesis of Cyclic Enones via Direct Palladium-Catalyzed Aerobic Dehydrogenation of Ketones (2011)

α,β-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO)(2)(TFA)(2) as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O(2) as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors.
Antennas for RFID applications (2010)

Antenna is one of the key factors in RFID systems. The performance of the reader / tag antennas shows significant effect on the reading range and detection accuracy of an RFID system. Since RFID systems operate at frequencies varying from low frequency (LF) to microwave frequencies (MWF), the RFID antenna designs are with distinct requirements. In this paper, we address the antenna design considerations for the latest RFID applications. Several antennas are exemplified to show the recently developed technologies for RFID antenna designs in specific RFID applications.
An intuitive justification and a simplified implementation of the MAP decoder for convolutional codes (1998)

An intuitive shortcut to understanding the maximum a posteriori (MAP) decoder is presented based on an approximation. This is shown to correspond to a dual-maxima computation combined with forward and backward recursions of Viterbi algorithm computations. The logarithmic version of the MAP algorithm can similarly be reduced to the same form by applying the same approximation. Conversely, if a correction term is added to the approximation, the exact MAP algorithm is recovered. It is also shown how the MAP decoder memory can be drastically reduced at the cost of a modest increase in processing speed.
Safety and effectiveness of ulotaront (SEP-363856) in schizophrenia: results of a 6-month, open-label extension study (2021)

Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptors agonist, has demonstrated efficacy in the treatment of patients with an acute exacerbation of schizophrenia in a 4-week, double-blind, placebo-controlled study. The aim of this 26-week open-label extension study was to evaluate the safety and effectiveness of ulotaront (25/50/75 mg/d) in patients who completed the initial 4-week study. Of the 193 4-week completers, 157 patients (81.3%) continued into the open-label extension study; 66.9% were completers. Among all extension phase patients, treatment with ulotaront was associated with minimal changes in body weight (mean [SD] change from double-blind baseline: -0.3 [3.7] kg), cholesterol (median change, -2.0 mg/dL), triglycerides (median, -5.0 mg/dL), and prolactin (female, median, -3.4 ng/mL; male, median, -2.7 ng/mL). Movement disorder scales showed no extrapyramidal effects. Twenty-six weeks of extension phase treatment was associated with a mean (95% CI) observed change from open-label baseline in the PANSS total score of -22.6 (-25.6, -19.6; effect size, 1.46), and a mean (95% CI) change in the CGI-Severity score of -1.0 (-1.2, -0.8; effect size, 1.07). Long-term treatment with the TAAR1 agonist ulotaront, in the daily dose range of 25-75 mg, was characterized by a relatively high completion rate, an adverse event profile notable for the absence of extrapyramidal-related adverse effects, a low liability for adverse weight and metabolic effects, and no effect on prolactin levels. Additional studies are needed to further confirm the long-term efficacy and safety of ulotaront.
The effect of interpolation on the BER performance of narrowband BPSK and (O)QPSK on Rician-fading channels (1994)

This paper deals with the bit error rate (BER) performance of a fully digitally implemented receiver performing coherent detection on a narrowband BPSK or (O)QPSK signal, transmitted over a slow non-frequency selective Rician fading channel. The considered digital receiver operates on samples of the received signal, taken by a fixed clock which is not synchronized to the transmitter clock. Signal samples needed for detection of the information sequence are obtained from interpolation between the available samples. In the case of nonideal interpolation a BER degradation occurs. By means of theoretical analysis, we demonstrate that even simple interpolators, operating at only a few samples per symbol, yield BER degradations that are limited to a small fraction of a dB. This paper is an extension of the work of Erup, Gardner and Harris (see ibid., vol.41, no.6, p.998-1008, 1993) where only the AWGN channel was considered and results were obtained by computer simulations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nanoscale selective growth and optical characteristics of quantum dots on III-V substrates prepared by diblock copolymer nanopatterning (2009)

As an alternate Quantum Dot (QD) fabrication method to self-assembled SK mode QDs, diblock copolymer nano-patterned QDs were investigated. By employing selective growth of QDs on diblock copolymer nano-patterned masks, independence from the problematic wetting layer and controllability on QD size and distribution associated with SK growth mode QDs were realized. The diblock copolymer nano-patterned masks were fabricated using a diblock copolymer template and a dielectric mask, and InxGa1-xAs QDs were selectively grown on patterned GaAs and InP substrates by Metalorganic Chemical Vapor Deposition (MOCVD). The optical properties from diblock copolymer patterned QDs on III-V substrates were investigated at low temperature.
Isolation of a Nonpathogenic Strain of Citrobacter sedlakii Which Expresses Escherichia coli O157 Antigen (1998)

A nonpathogenic strain of Citrobacter sedlakii which expresses the Escherichia coli O157 antigen is described. The discovery of this strain emphasizes the necessity of additional biochemical and/or toxigenicity testing when isolates react with E. coli O157 latex reagents.
Natural Analogue Peptides of an HIV-1 GP120 T-Helper Epitope Antagonize Response of GP120-Specific Human CD4 T-Cell Clones (2000)

Neutralizing antibodies and specific cytotoxic T lymphocytes (CTL) may contribute to controlling viral spread, and ideally, to virus clearance in HIV infection. Both effector mechanisms depend on specific CD4 T-helper (Th) cells. Nevertheless, HIV hypervariability facilitates appearance of escape mutants for antibodies and for CTL responses. Here we also show that natural mutations (i.e., from sequences of different HIV strains) in an immunodominant Th epitope recognized by human CD4 clones specific for the envelope glycoprotein gp120 escape CD4 T-cell recognition. Furthermore, several natural analogue peptides exert an antagonistic function by inhibiting proliferative response of T cells specific to gp120 with a wild-type sequence. If similar events occur in vivo, they may represent an additional escape mechanism for HIV. In fact, antagonism for CD4 Th response may occur during superinfection with a different strain, or with the appearance of a variant carrying a mutated antagonistic sequence. In both cases, impaired Th cell function could lead to reduced immune control of HIV infection by interfering with CTL and antibody response.