gebhart/patrepeval huggingface dataset:
Surgical wound pain: a trial of two treatments (1996)

In order to compare postoperative incisional pain intensity, a prospective randomised controlled trial was conducted with two patient groups: a treatment group (treated with a film dressing left intact until suture removal) and a control group (treated with the existing wound-care protocol of a dry dressing removed after 48 hours). Patient-controlled analgesia consumption and infection rates in the two groups were also compared. A sample of 30 patients undergoing total abdominal hysterectomy was selected. Incisional wound pain, measured using a visual analogue scale (at rest, on movement and a 24-hour average) and the McGill Pain Questionnaire were recorded daily until discharge (four days). The pain scores were not significantly different between the groups on Days 1 or 2 postoperatively. However, on Day 3 (when the wounds in the dry dressing group were exposed), there was a statistically significant difference in 24-hour average pain. Those whose wounds were covered with the film dressing experienced less pain and requested fewer non-steroidal anti-inflammatory drugs on Day 3. Maintaining a cover over a surgical wound until suture removal appears to promote pain relief when compared to exposing wounds to the air. A film dressing was useful in this respect as it allowed inspection of the wound without removing the dressing.
Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 225 Upregulates p27<sup>KIP1</sup> and p15<sup>INK4B</sup> and Induces G1 Arrest in Oral Squamous Carcinoma Cell Lines (2002)

Epidermal growth factor receptor (EGFR) regulates the growth and progression of human oral squamous cell carcinoma (SCC). Recently, the link between EGFR signaling and the cell cycle has been identified. Some reports have described that EGFR-blocking monoclonal antibody 225 (mAb225) induced G1 arrest and inhibited the growth of various cancer cells. The purpose of this study was to evaluate the effect of mAb225 on human oral SCC cell lines. Exposure to mAb225 in culture inhibited the growth of oral SCC cell lines in an EGFR number-independent manner, with the percent inhibition ranging from 13.8 to 76.6%. Flow-cytometric analysis demonstrated that treatment with mAb225 induced cell accumulation in G1 phase, accompanied by a decrease in the percentage of cells in the S phase. Apoptosis was not seen in this study. G1 arrest was accompanied by a decrease in CDK2-, CDK4-, and CDK6-associated histone H1 kinase activities, and an increase in the expression levels of cell cycle inhibitors p27(KIP1) and p15(INK4B). These results suggested that the antiproliferative effect of EGFR blockade by mAb225 in oral SCC may be mediated by p27(KIP1) and p15(INK4B).
Novel ultra high density flash memory with a stacked-surrounding gate transistor (S-SGT) structured cell (2002)

In order to overcome the limitation of cell area of 4F/sup 2/ per bit in conventional NAND flash memory cells, stacked-surrounding gate transistor (S-SGT) structured cell is proposed. The new structured cell achieves cell area of 4F/sup 2//N per bit, where N is the number of stacked memory cells in one silicon pillar, without using multibit per memory cell technology. The S-SGT structured cell consisting of 2 stacked memory cells in one silicon pillar achieves cell area per bit less than 50% of the smallest reported NAND structured cell. The novel S-SGT structured cells are fabricated by vertical self-aligned processes using a 0.2/spl mu/m design rule. The S-SGT, structured cell can be programmed and erased by uniform injection and uniform emission of Fowler-Nordheim (F-N) tunneling electrons over the whole channel area of the memory cell, respectively, the same as conventional NAND structured cell. This high performance S-SGT structured cell is applicable to high-density nonvolatile memories as large as 16G/64G bit flash memory or beyond.
IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection (2004)

IL-15 is known to be critical in the homeostasis of Ag-specific memory CD8(+) T cells following acute viral infection. However, little is known about the homeostatic requirements of memory CD8(+) T cells during a latent viral infection. We have used the murine gammaherpesvirus-68 (MHV-68) model system to investigate whether IL-15 is necessary for the maintenance of memory CD8(+) T cells during a latent viral infection. IL-15 is not essential either for the initial control of MHV-68 infection or for the maintenance of MHV-68-specific memory CD8(+) T cells. Even at 140 days postinfection, the proportion of CD8(+) T cells recognizing the MHV-68 epitopes were the same as in control mice. The maintenance of these memory CD8(+) T cells was attributable to their ability to turn over in vivo, probably in response to the presence of low levels of Ag. IL-15(-/-) mice had a significantly higher turnover rate within the virus-specific memory CD8(+) T cell population, which was the result of increased levels of viral gene expression rather than an increase in viral load. These cells did not accumulate in the spleens of the IL-15(-/-) mice due to an increased sensitivity to apoptosis as a result of decreased Bcl-2 levels. Intriguingly, memory CD8(+) T cells from latently infected mice failed to undergo homeostatic proliferation in a naive secondary host. These data highlight fundamental differences between memory CD8(+) T cells engaged in active immune surveillance of latent viral infections vs memory CD8(+) T cells found after acute viral infections.
[Nasal CPAP therapy of obstructive sleep apnea syndrome with expiratory pressure reduction: a prospective randomized study of acceptance of treatment during therapy initiation]. (1997)

It is often difficult to achieve adequate acceptance of nasal continuous positive airway pressure (CPAP) therapy by patients with OSA. Many patients find it particularly inconvenient to expire against the treatment pressure. With this in mind, we have attempted to improve acceptance of CPAP therapy by using a bilevel system that reduces the treatment pressure during expiration. 52 patients were randomized either to initial treatment with CPAP therapy followed by bilevel treatment, or to treatment in reversed order. During bilevel therapy the ratio of inspiratory to expiratory pressure was fixed at 1:0.6. After each treatment the patients were interviewed on the basis of visual analogue scales to establish their subjective evaluation of such parameters as general well-being, quality of sleep, comparison of the respective treatment pressures, and possible preference for one of the two systems for long-term treatment. The minimal effective inspiratory treatment pressure during bilevel therapy (IPAP) and the minimal effective CPAP pressure were closely correlated (r = 0.89). There was no difference between the apnoea hypopnoea indices during CPAP therapy as compared with bilevel therapy. Most patients (57%) felt the treatment pressure with the bilevel system to be lower (p = 0.048). There were no differences in patients' well-being early in the morning, or in their assessment of sleep quality. The majority of patients (52%) preferred bilevel therapy for long term treatment, while 38% preferred CPAP therapy (n.s.). In a subgroup of 13 patients with a treatment pressure of > or = 10 mbar during CPAP therapy 10 patients (77%) gave preference to the bilevel system (n.s.). In a considerable number of patients the acceptance of treatment can be improved by using a bilevel system for initiation of nasal positive pressure therapy.
Rabbit muscle aldolase as a catalyst in organic synthesis (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRabbit muscle aldolase as a catalyst in organic synthesisMark D. Bednarski, Ethan S. Simon, Norbert Bischofberger, Wolf Dieter Fessner, Mahn Joo Kim, Watson Lees, Tohru Saito, Herbert Waldmann, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1989, 111, 2, 627–635Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00184a034https://doi.org/10.1021/ja00184a034research-articleACS PublicationsRequest reuse permissionsArticle Views1126Altmetric-Citations194LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway (2000)

Antigens such as MUC1 coupled to oxidized mannan lead to rapid and efficient MHC class I presentation to CD8+ cells and a preferential T1 response; after reduction there is class II presentation and a T2 immune response. We now show that the selective advantage of the oxidized mannan-MUC1 is due to the presence of aldehydes and not Schiff bases, and that oxidized mannan-MUC1 binds to the mannose and not scavenger receptors and is internalized and presented by MHC class I molecules 1,000 times more efficiently than when reduced. After internalization there is rapid access to the class I pathway via endosomes but not lysosomes, proteasomal processing and transport to the endoplasmic reticulum, Golgi apparatus and cell surface. Aldehydes cause rapid entry into the class I pathway, and can therefore direct the subsequent immune response.
Metal-Vapor Deposition Modulation on Soft Polymer Surfaces (2012)

Metal-vapor deposition modulation on soft polymer surfaces and its applications are reported. A soft viscous surface of poly(dimethylsiloxane) (PDMS) with a glass transition temperature (Tg) of -123 °C showed perfect desorption at room temperature for many kinds of metal vapor. Metal-vapor deposition modulation on PDMS surfaces was applied to the Ca-cathode patterning of an organic light-emitting device, the preparation of thin-film Pb fuse, and the Mg vapor transportation by a pipeline, indicating great potential in various fields of basic research, engineering, and industry.
Contact Sensitivity and Systemic Antibody Responses in Dairy Cows Treated with Recombinant Bovine Somatotropin (1992)

Effects of exogenous bST on humoral and cell-mediated immune responses in lactating dairy cows were determined. The systemic antibody response to human erythrocytes and the cutaneous sensitivity response induced by dinitrochlorobenzene were the immune responses investigated. Cows were treated with either 0, 10.3, or 20.6 mg of bST/d for 266 d starting between wk 4 and 5 of lactation. Systemic immunizations and contact sensitivity were initiated during midlactation, 22 wk after bST treatments began. Hemagglutinating antibody titers and areas under the response profiles were not statistically different for bST-treated versus control cows. The cutaneous sensitivity response was similarly not affected by bST administration. Present antibody titer results agreed with our previous observations that bST did not affect serum IgM concentrations, but the cutaneous sensitivity results were in contrast with our finding of augmented proliferative responsiveness of mitogen-stimulated peripheral blood lymphocytes in bST-treated versus control cows. It is possible that exogenous bST affects some immune processes and lymphocyte subsets and not others. Further research is required to determine the practical significance of the variable immunomodulation elicited by exogenous bST.
Mass fraction profiling based on x-ray tomography and its application to characterizing porous silica boules (1987)

Mass fraction profiling is a specialized tomographic technique designed to allow one to measure the concentration profiles of the component species of a synthetic composite material. While developed for the express purpose of determining the dopant, density, and porosity profiles of unsintered soot boules, the method hould also be useful in analyzing other types of ceramic such as dried gels. Mass fraction profiling amounts to a three-step process consisting of scanning the object of interest with well-collimated beams of x rays, reconstructing the attenuation coefficient profiles for several x-ray energies, and generating the density and concentration or mass fraction profiles. The method for determining these profiles is outlined, and some measurement results obtained for soot boules are presented.
The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease. (1989)

The lymphocytes surrounding Reed-Sternberg cells may play an important role in the pathogenesis of Hodgkin's disease. In this study, T cells in different subtypes of Hodgkin's disease were analyzed in situ by an immunoperoxidase method employing a panel of antibodies, including several paraffin tissue-reactive monoclonal antibodies. The T cells in Hodgkin's disease-involved tissues were found to be activated CD4-positive T cells that are UCHL1+ and CD45R-. This immunophenotype is compatible with an activated helper-inducer memory T cell population. The T cells in the nodular lymphocyte predominance subtype were found to have additional positivity for Leu 7, indicating a subpopulation of CD4+ T cells, normally confined to the light zone of germinal centers of secondary follicles.
Diastereo- and Enantioselective Alkylation of α-Imino Esters with Enol Silanes Catalyzed by (R)-Tol-BINAP−CuClO4·(MeCN)2 (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDiastereo- and Enantioselective Alkylation of α-Imino Esters with Enol Silanes Catalyzed by (R)-Tol-BINAP−CuClO4·(MeCN)2Dana Ferraris, Brandon Young, Christopher Cox, William J. Drury, Travis Dudding, and Thomas LectkaView Author Information Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218 Cite this: J. Org. Chem. 1998, 63, 18, 6090–6091Publication Date (Web):August 20, 1998Publication History Received8 June 1998Published online20 August 1998Published inissue 1 September 1998https://pubs.acs.org/doi/10.1021/jo981079hhttps://doi.org/10.1021/jo981079hrapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views732Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Catalysts,Group 14 compounds,Inorganic compounds,Organic compounds,Stereoselectivity Get e-Alerts
The Inhibitory Effect of IFN-γ on Protease HTRA1 Expression in Rheumatoid Arthritis (2014)

The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need to be determined. In this study, we demonstrated that IFN-γ significantly inhibited the basal and LPS-induced HTRA1 expression in fibroblasts and macrophages, which are two major cells for HTRA1 production in RA. Importantly, the inhibitory effect of IFN-γ on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells. In parallel with the enhanced CIA incidence and pathological changes in IFN-γ-deficient mice, HTRA1 expression in the joint tissues was also increased as determined by real-time PCR and Western blots. IFN-γ deficiency increased the incidence of CIA and the pathological severity in mice. Neutralization of HTRA1 by Ab significantly reversed the enhanced CIA frequency and severity in IFN-γ-deficient mice. Mechanistically, IFN-γ negatively controls HTRA1 expression through activation of p38 MAPK/STAT1 pathway. Dual luciferase reporter assay and chromatin immunoprecipitation analysis showed that STAT1 could directly bind to HTRA1 promoter after IFN-γ stimulation. This study offers new insights into the molecular regulation of HTRA1 expression and its role in RA pathogenesis, which may have significant impact on clinical therapy for RA and possibly other HTRA1-related diseases, including osteoarthritis, age-related macular degeneration, and cancer.
Wind Speed and Rotor Position Sensorless Control for Direct-Drive PMG Wind Turbines (2011)

This paper proposes a wind speed and rotor position sensorless control for wind turbines directly driving permanent magnetic generators (PMGs). A sliding-mode observer is designed to estimate the rotor position of the PMG by using the measured stator currents and the commanded stator voltages obtained from the control scheme of the machine-side converter of the PMG wind turbine. The rotor speed of the PMG (i.e., the turbine shaft speed) is estimated from its back electromotive force using a model adaptive reference system observer. Based on the measured output electrical power and estimated rotor speed of the PMG, the mechanical power of the turbine is estimated by taking into account the power losses of the wind turbine generator system. A back-propagation artificial neural network is then designed to estimate the wind speed in real time by using the estimated turbine shaft speed and mechanical power. The estimated wind speed is used to determine the optimal shaft speed reference for the PMG control system. Finally, a sensorless control is developed for the PMG wind turbines to continuously generate the maximum electrical power without using any wind speed or rotor position sensors. The validity of the proposed estimation and control algorithms are shown by simulation studies on a 3-kW PMG wind turbine and are further demonstrated by experimental results on a 300-W practical PMG wind turbine.
GIGA+ : Scalable Directories for Shared File Systems (CMU-PDL-08-110) (2018)

Traditionally file system designs have envisioned directories as a means of organizing files for human viewing; that is, directories typically contain a few tens to thousands of files. Users of large, fast file systems have begun to put millions of files into single directories, for example, as simple databases. Furthermore, large-scale applications running on clusters with tens to hundreds of thousands of cores can burstily create files using all compute cores, amassing bursts of hundreds of thousands of creates or more. In this paper, we revisit data-structures to build large file system directories that contain millions to billions of files and to quickly grow the number of files when many nodes are creating concurrently. We extend classic ideas of efficient resizeable hash-tables and inconsistent client hints to a highly concurrent distributed directory service. Our techniques use a dense bitmap encoding to indicate which of the possibly created hash partitions really exist, to allow all partitions to split independently, and to correct stale client hints with multiple changes per update. We implement our technique, Giga+, using the FUSE user-level file system API layered on Linux ext3. We measured our prototype on a 100-node cluster using the UCAR Metarates benchmark for concurrently creating a total of 12 million files in a single directory. In a configuration of 32 servers, Giga+ delivers scalable throughput with a peak of 8,369 file creates/second, comparable to or better than the best current file system implementations.
Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence (2018)

Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an "innate-like" behavior and are more resilient to the environment as compared to "adaptive-like" Vδ1+ T cells.
Oxide enthalpy of formation and band gap energy as accurate descriptors of oxygen vacancy formation energetics (2014)

Despite the fundamental role oxygen vacancy formation energies play in a broad range of important energy applications, their relationships with the intrinsic bulk properties of solid oxides remain elusive. Our study of oxygen vacancy formation in La1−xSrxBO3 perovskites (BCr, Mn, Fe, Co, and Ni) conducted using modern, electronic structure theory and solid-state defect models demonstrates that a combination of two fundamental and intrinsic materials properties, the oxide enthalpy of formation and the minimum band gap energy, accurately correlate with oxygen vacancy formation energies. The energy to form a single, neutral oxygen vacancy decreases with both the oxide enthalpy of formation and the band gap energy in agreement with the relation of the former to metal–oxygen bond strengths and of the latter to the energy of the oxygen vacancy electron density redistribution. These findings extend our understanding of the nature of oxygen vacancy formation in complex oxides and provide a fundamental method for predicting oxygen vacancy formation energies using purely intrinsic bulk properties.
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. (1990)

Entry into mitosis during the somatic cell cycle is regulated in response to signals that monitor the completion of DNA replication, the integrity of the nuclear genome, and, possibly, the increase in cellular mass during the cell cycle. It has been postulated that the operation of this cell cycle control involves the gradual accumulation of rate-limiting mitotic inducers, which trigger nuclear division when their cellular concentration reaches a critical level. We have cloned a human gene, which we call CDC25, whose product may function as a mitotic inducer. This human gene encodes a protein with a predicted molecular mass of 53,000 daltons whose C-terminal domain shares about 37% sequence identity with the fission yeast cdc25+ mitotic inducer. The human CDC25 gene rescues the defect of a fission yeast temperature-sensitive (ts) cdc25ts mutant that is unable to initiate mitosis. In HeLa cells CDC25 mRNA levels are very low in G1 and increase at least 4-fold as cells progress towards M phase. These data suggest that in human cells, as in fission yeast, the accumulation of CDC25 mitotic inducer during G2 may play a key role in regulating the timing of mitosis.