gebhart/patrepeval huggingface dataset:
Usability and evaluation of a deployed 4G network prototype (2005)

This article presents a field evaluation of an IP-based architecture for heterogeneous environments that has been developed under the aegis of the Moby Dick project, covering UMTS-like (universal mobile telecommunications system) TD-CDMA (time division-code division multiple access) wireless access technology, wireless and wired LANs. The architecture treats all transmission capabilities as basic physical and data-link layers, and replaces all higher-level tasks by IP-based strategies. The Moby Dick architecture incorporates mobile IPv6, fast handovers, AAA-control (authentication, authorisation, accounting), charging and quality of service (QoS) in an integrated framework. The architecture further allows for optimised control on the radio link layer resources. It has been implemented and tested by expert users, and evaluated by real users on field trials with multiple services available.
Properties of subunits and aggregates of blue-green algal biliproteins (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleProperties of subunits and aggregates of blue-green algal biliproteinsAllen Bennett and Lawrence BogoradCite this: Biochemistry 1971, 10, 19, 3625–3634Publication Date (Print):September 14, 1971Publication History Published online1 May 2002Published inissue 14 September 1971https://doi.org/10.1021/bi00795a022RIGHTS & PERMISSIONSArticle Views385Altmetric-Citations120LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (3 MB) Get e-Alerts Get e-Alerts
Immobilization of poly(ethylene glycol) onto a poly(vinyl alcohol) hydrogel: 2. Evaluation of thrombogenicity (1993)

Immobilized polyethylene glycol (PEG) reduced the amount of bovine serum albumin (BSA) adsorbed on polyvinyl alcohol (PVA) hydrogel, but did not reduce the platelet reactivity of the hydrogel surface. PEG, molecular weight (MW) 2000 or 5000, with or without a monomethoxy end group, was covalently bound to glutaraldehyde-crosslinked PVA either through a cyclic acetal or an urethane functional group with a surface coverage of 70% (as measured by x-ray photoelectron spectroscopy [XPS]). Immobilization of monomethoxy-PEG via a cyclic acetal reduced BSA adsorption to PVA from 11 +/- 2 nmol/m2 to 3.9 +/- 0.3 nmol/m2 and 3.3 +/- 0.3 nmol/m2 for MW 2000 and 5000, respectively. Similarly, urethane bound PEG reduced adsorption to 3.5 +/- 1.6 nmol/m2 for MW 2000 and 5.4 +/- 1.0 nmol/m2 for MW 5000. Whole blood clotting times of PVA (using a Chandler loop) were not affected by covalently linked PEG, although the initial rate of thrombin generation at the surface, measured using a fluorogenic substrate, was marginally reduced; a rate constant of 4.2 +/- 0.1 cm/sec and 3.5 +/- 0.1 cm/sec were obtained for MW 2000 and 5000, respectively, compared to 5.6 +/- 1.0 cm/sec for PVA. Ex vivo evaluation using a canine arteriovenous shunt revealed that the hydrogel, with or without bound PEG, reduced circulating platelet levels by 35-70% after 4 days. The initial fractional rate of platelet destruction determined from measurement of platelet cyclooxygenase activity, indicated that cyclic acetal or urethane bound PEG of either molecular weight had no effect on platelet consumption produced by PVA.(ABSTRACT TRUNCATED AT 250 WORDS)
Refractive Errors Induced by Displacement of Intraocular Lenses within the Pseudophakic Eye (1989)

Simple methods were developed to estimate refractive errors when intraocular lenses are not fitted optimally within pseudophakic eyes. The accuracy of these methods was determined by comparing results obtained with them to results obtained by raytracing through a model eye. Accuracy was good for longitudinal displacement and tilting, and reasonable for transverse displacement. Refractive errors are related linearly to the magnitude of the longitudinal displacement, and are related to the square of the magnitude of tilt or transverse displacement. The refractive error upon transverse displacement is quadratically dependent upon lens shape.
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165 (1997)

Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells (EC) in vitro and a major regulator of angiogenesis in vivo. VEGF121 and VEGF165 are the most abundant of the five known VEGF isoforms. The structural difference between these two is the presence in VEGF165 of 44 amino acids encoded by exon 7 lacking in VEGF121. It was previously shown that VEGF165 and VEGF121 both bind to KDR/Flk-1 and Flt-1 but that VEGF165 binds in addition to a novel receptor (Soker, S., Fidder, H., Neufeld, G., and Klagsbrun, M. (1996) J. Biol. Chem. 271, 5761-5767). The binding of VEGF165 to this VEGF165-specific receptor (VEGF165R) is mediated by the exon 7-encoded domain. To investigate the biological role of this domain further, a glutathione S-transferase fusion protein corresponding to the VEGF165 exon 7-encoded domain was prepared. The fusion protein inhibited binding of 125I-VEGF165 to VEGF165R on human umbilical vein-derived EC (HUVEC) and MDA-MB-231 tumor cells. The fusion protein also inhibited significantly 125I-VEGF165 binding to KDR/Flk-1 on HUVEC but not on porcine EC which express KDR/Flk-1 alone. VEGF165 had a 2-fold higher mitogenic activity for HUVEC than did VEGF121. The exon 7 fusion protein inhibited VEGF165-induced HUVEC proliferation by 60% to about the level stimulated by VEGF121. Unexpectedly, the fusion protein also inhibited HUVEC proliferation in response to VEGF121. Deletion analysis revealed that a core inhibitory domain exists within the C-terminal 23-amino acid portion of the exon 7-encoded domain and that a cysteine residue at position 22 in exon 7 is critical for inhibition. It was concluded that the exon 7-encoded domain of VEGF165 enhances its mitogenic activity for HUVEC by interacting with VEGF165R and modulating KDR/Flk-1-mediated mitogenicity indirectly and that exon 7-derived peptides may be useful VEGF antagonists in angiogenesis-associated diseases.
Treatment of bladder cancer with a combination of hyperthermia, radiation and bleomycin (1984)

The treatment of urinary bladder cancer with hyperthermia in combination with radiation and bleomycin was investigated. Immediately following a daily course of external bladder irradiation (150-200 rad; total 4 week exposure of 3500-4000 rad), patients diagnosed with transitional cell carcinoma of the bladder were irrigated with a solution of warmed saline (intravesical temperature, 42 degrees C-43 degrees C), containing 30 micrograms/ml bleomycin. Of a total of 33 patients, complete responses were observed in 14 patients, and partial responses were observed in 10. The side effects of the combined treatment were limited to local symptoms of bladder and urethral irritation. These preliminary results suggest that the combined use of hyperthermia, radiation, and bleomycin may represent an effective conservative therapy for the management of bladder cancer in humans.
Image Captioning with Semantic Attention (2016)

Automatically generating a natural language description of an image has attracted interests recently both because of its importance in practical applications and because it connects two major artificial intelligence fields: computer vision and natural language processing. Existing approaches are either top-down, which start from a gist of an image and convert it into words, or bottom-up, which come up with words describing various aspects of an image and then combine them. In this paper, we propose a new algorithm that combines both approaches through a model of semantic attention. Our algorithm learns to selectively attend to semantic concept proposals and fuse them into hidden states and outputs of recurrent neural networks. The selection and fusion form a feedback connecting the top-down and bottom-up computation. We evaluate our algorithm on two public benchmarks: Microsoft COCO and Flickr30K. Experimental results show that our algorithm significantly outperforms the state-of-the-art approaches consistently across different evaluation metrics.
A stacked CMOS technology on SOI substrate (2004)

A stacked CMOS technology fabricated on semiconductor-on-insulator (SOI) wafers with the p-MOSFET on the SOI film and the n-MOSFET on the bulk substrate is demonstrated. The technology provides a number of advantages, including: 1) single crystal multi-layer of active devices; 2) self-aligned double-gate p-MOSFET with thick source/drain and thin channel regions; 3) self-aligned channel region of n-MOSFET to p-MOSFET stacked perfectly on top of each other; 4) significant area saving; and 5) reduced interconnect distance and loading. Experimental results show that the fabricated double-gate p-MOSFET has a nearly ideal subthreshold swing and almost the same current drive as the n-MOSFET with the same lateral width, resulting in a highly compact and completely overlap stacked CMOS inverter.
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor (1982)

Cultured human lymphocytes and rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoreses. In both cell types the 95,000-dalton (beta) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action.
Talking Face Generation by Adversarially Disentangled Audio-Visual Representation (2018)

Talking face generation aims to synthesize a sequence of face images that correspond to a clip of speech. This is a challenging task because face appearance variation and semantics of speech are coupled together in the subtle movements of the talking face regions. Existing works either construct specific face appearance model on specific subjects or model the transformation between lip motion and speech. In this work, we integrate both aspects and enable arbitrary-subject talking face generation by learning disentangled audio-visual representation. We find that the talking face sequence is actually a composition of both subject-related information and speech-related information. These two spaces are then explicitly disentangled through a novel associative-and-adversarial training process. This disentangled representation has an advantage where both audio and video can serve as inputs for generation. Extensive experiments show that the proposed approach generates realistic talking face sequences on arbitrary subjects with much clearer lip motion patterns than previous work. We also demonstrate the learned audio-visual representation is extremely useful for the tasks of automatic lip reading and audio-video retrieval.
Helicobacter pylori cagA+ Strains and Dissociation of Gastric Epithelial Cell Proliferation From Apoptosis (1997)

Background: Infection with Helicobacter pylori induces chronic gastritis in virtually all infected persons, and such gastritis has been associated with an increased risk of developing gastric cancer. This risk is further enhanced with cagA + (positive for cytotoxin-associated gene A) H. pylori strains and may be a consequence of induced gastric cell proliferation and/or alteration in apoptosis (programmed cell death) in the gastric epithelium. Purpose: To determine whether the H. pylori cagA genotype and another virulence-related characteristic, the vacA (vacuolating cytotoxin A) s1a genotype, differentially affect epithelial cell proliferation, apoptosis, and the histologic parameters of inflammation and injury, we quantitated these characteristics in infected and uninfected persons. Methods: Fifty patients underwent upper gastrointestinal endoscopy, and biopsy specimens were taken. Apoptotic cells in the specimens were quantitated after terminal deoxynucleotidyl transferase labeling of DNA fragments with digoxigenin-deoxyuridine triphosphate; epithelial cell proliferation was scored by immunohistochemical analysis of the proliferation-associated antigen Ki-67. Antibodies directed against H. pylori and CagA protein were measured in the serum of patients by means of enzyme-linked immunosorbent assays. Analysis of H. pylori genomic DNA, by use of the polymerase chain reaction, was performed to determine the cagA and vacA genotypes. Acute and chronic inflammation, epithelial cell degeneration, mucin depletion, intestinal meta-
Nivolumab in NSCLC: latest evidence and clinical potential (2015)

New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.
In-Hospital Cost of Percutaneous Coronary Revascularization (1995)

Background Hospital charges associated with percutaneous transluminal coronary revascularization (PTCR) in the United States exceeded $6 billion in 1994 and are likely to be constrained in some manner in the near future. Despite this high cost to the public, little is known about the major determinants and sources of variability of PTCR. Methods and Results From a consecutive series of 1258 procedures with attempted PTCR at a single tertiary referral center, we analyzed 65 clinical, angiographic, physician, and outcome variables as potential correlates of total (hospital and physician) cost. Direct and indirect costs, both hospital and physician, were determined on the basis of resource utilization using “top-down” methodology and were available for 1237 procedures (1086 patients) (98.3%). Mean (±SD) patient age was 62±11 years, 76% were male, 3% had acute myocardial infarction, 71% had unstable angina, 58% had multivessel disease, left ventricular ejection fraction was 54±12%, 26% had use of at least one nonballoon revascularization device, and median length of stay was 4.4 days. Procedural success was obtained in 89%, and major complications (death, bypass surgery, or Q-wave myocardial infarction) occurred in 3.8%. The median cost was $9176, but it was asymmetrically distributed, and the interquartile and total ranges were wide ($7333 to $13 845 and $3422 to $193 474, respectively). Analyses of independent correlates of cost and log e (cost) were performed using multivariate linear regression in training and test populations. Modeling found 15 independent preprocedural correlates of log e (cost) ( R 2 =.37) and 23 overall correlates ( R 2 =.65), excluding length of stay per se. Addition of length of stay to the model increased the explanatory power of the model to R 2 =.82. Preprocedural variables most predictive of log e (cost) included presentation with acute myocardial infarction, decision delay (&gt;48 hours between admission and diagnostic angiography and/or &gt;24 hours between angiography and intervention), weekend delay, use of intra-aortic balloon counterpulsation, intention to stent, creatinine ≥2.0 mg%, and lesion complexity (modified American College of Cardiology/American Heart Association score) (all P &lt;.001). In the model that included postprocedural variables as well, length of stay, noncardiac death, urgent bypass surgery, use of the Rotablator, Q-wave myocardial infarction, rise in creatinine ≥1.0%, and blood product transfusion were all strong independent correlates of log e (cost) ( P &lt;.001). Conclusions The range of total hospital costs associated with percutaneous intervention is extraordinarily wide. Baseline patient characteristics account for nearly half of the explained variance, but procedural complications and system delays account for much of the remainder. Quantification of the determinants of cost may promote more economically efficient care in the future.
Analysis of homeodomain function by structure-based design of a transcription factor. (1995)

The homeodomain is a 60-amino acid module which mediates critical protein-DNA and protein-protein interactions for a large family of regulatory proteins. We have used structure-based design to analyze the ability of the Oct-1 homeodomain to nucleate an enhancer complex. The Oct-1 protein regulates herpes simplex virus (HSV) gene expression by participating in the formation of a multiprotein complex (C1 complex) which regulates alpha (immediate early) genes. We recently described the design of ZFHD1, a chimeric transcription factor containing zinc fingers 1 and 2 of Zif268, a four-residue linker, and the Oct-1 homeodomain. In the presence of alpha-transinduction factor and C1 factor, ZFHD1 efficiently nucleates formation of the C1 complex in vitro and specifically activates gene expression in vivo. The sequence specificity of ZFHD1 recruits C1 complex formation to an enhancer element which is not efficiently recognized by Oct-1. ZFHD1 function depends on the recognition of the Oct-1 homeodomain surface. These results prove that the Oct-1 homeodomain mediates all the protein-protein interactions that are required to efficiently recruit alpha-transinduction factor and C1 factor into a C1 complex. The structure-based design of transcription factors should provide valuable tools for dissecting the interactions of DNA-bound domains in other regulatory circuits.
Expression of a human cell adhesion molecule, MUC18, in prostate cancer cell lines and tissues (2001)

We therefore conclude that MUC18 is expressed at higher levels in pre-malignant and malignant prostatic epithelium, including metastasis. We suggest that over-expression of MUC18 may be a new marker of human prostate cancer and also implicates its possible role in development and progression of prostate cancer.
Thermotropic liquid crystal behaviour of gemini imidazolium-based ionic amphiphiles (2010)

Thermotropic ionic liquid crystals (LCs) are useful for a number of applications such as anisotropic ion transport and as organised reaction media/solvents because of their ordered fluid properties and intrinsic charge units. A large number of different ionic LC architectures are known, but only a handful of examples of gemini (i.e. paired or dimeric) ionic LCs have been prepared and studied. In this work, a series of 20 new symmetric, imidazolium-based, gemini cationic LCs containing two bridged imidazolium cations and two pendant alkyl chains was synthesised, and the thermotropic LC behaviours were characterised. The imidazolium unit provides a highly tunable and modular platform for the design and synthesis of gemini cationic LCs which offers excellent structure control. As expected, the thermotropic LC properties of these new amphilphilic, gemini ionic LCs were found to be strongly influenced by the length of the spacer between the imidazolium units, the length of the pendant alkyl tails, and the nature of the anion. Smectic A (SmA) thermotropic LC phases were observed in more than half of the gemini imidazolium LC systems studied.
Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. (1994)

Interferon regulatory factor 1 (IRF-1) and IRF-2 are structurally similar DNA-binding factors which were originally identified as regulators of the type I interferon (IFN) system; the former functions as a transcriptional activator, and the latter represses IRF-1 function by competing for the same cis elements. More recent studies have revealed new roles of the two factors in the regulation of cell growth; IRF-1 and IRF-2 manifest antioncogenic and oncogenic activities, respectively. In this study, we determined the structures and chromosomal locations of the human IRF-1 and IRF-2 genes and further characterized the promoters of the respective genes. Comparison of exon-intron organization of the two genes revealed a common evolutionary structure, notably within the exons encoding the N-terminal portions of the two factors. We confirmed the chromosomal mapping of the human IRF-1 gene to 5q31.1 and newly assigned the IRF-2 gene to 4q35.1, using fluorescence in situ hybridization. The 5' regulatory regions of both genes contain highly GC-rich sequences and consensus binding sequences for several known transcription factors, including NF-kappa B. Interestingly, one IRF binding site was found within the IRF-2 promoter, and expression of the IRF-2 gene was affected by both transient and stable IRF-1 expression. In addition, one potential IFN-gamma-activated sequence was found within the IRF-1 promoter. Thus, these results may shed light on the complex gene network involved in regulation of the IFN system.
Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer (2020)

The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein family, which plays an extremely important role in the splicing process of precursor RNA. The SRs recognize the splicing elements on precursor RNA, then recruit and assemble spliceosome to promote or inhibit the occurrence of splicing events. In tumors, aberrant expression of SRs causes abnormal splicing of RNA, contributing to proliferation, migration and apoptosis resistance of tumor cells. Here, we reviewed the vital role of SRs in various tumors and discussed the promise of analyzing mRNA alternative splicing events in tumor. Further, we highlight the challenges and discussed the perspectives for the identification of new potential targets for cancer therapy via SRs family members.