gebhart/patrepeval huggingface dataset:
Temporal Changes in Myocardial Perfusion Patterns in Patients With Reperfused Anterior Wall Myocardial Infarction (1995)

(1) Recovery from ischemic microvascular damage is generally observed in the late stage of AMI in association with improvement in myocardial contractile function. The degree of improvement in contractile function and microvascular integrity, however, varies among patients. (2) Contrast peak intensity in the late stage of infarction may provide a useful estimate of myocardial viability.
In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor (1999)

These data indicate that the continuous block of the oncogenic tyrosine kinase of Bcr/Abl protein is needed to produce important biologic effects in vivo.
An object oriented approach to automating patient medical records (2002)

It is pointed out that, in automating patient records, one must consider the conversion of existing paper records, the records generated by various heterogeneous departmental medical information systems, and the different media (graphics, image, and voice) output created by some modern automated medical instrumentations. In an attempt to solve this complex problem, an object-oriented medical record model is adopted. A catalyst solution called the personal medical disk is proposed which allows and induces medical institutions to develop an all-digital medical record system at their own pace. A conceptual model has been implemented on an intelligent workstation as a stand-alone system. It is believed that using an object-oriented approach will allow rapid development, easier modification, and simpler maintenance of software to be achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release (1994)

The present study examined the effects of acute, continuous infusion of nicotine in either the ventral tegmental area or the nucleus accumbens on extracellular concentrations of dopamine in the nucleus accumbens by applying in vivo microdialysis in freely moving rats. Nicotine (1000 microM) infusion for 80 min. in the ventral tegmental area produced a long-lasting increase in accumbal dopamine, whereas similar nicotine infusion in the nucleus accumbens increased dopamine levels only within the first 20 min. of administration. This effect was blocked by systemic pretreatment with the nicotinic receptor antagonist mecamylamine (1 mg/kg, subcutaneously). In contrast to the effects of nicotine, N-methyl-D-aspartate infusion in the ventral tegmental area as well as in the nucleus accumbens produced a long-lasting increase in accumbal dopamine levels. The more procounced effect of infusion of nicotine in the ventral tegmental area as compared to the nucleus accumbens on accumbal dopamine release may be due to a lower rate or even lack of tolerance to nicotine's stimulatory action in the ventral tegmental area. These results support the notion that nicotinic receptors in the ventral tegmental area may be of greater importance than those located in the nucleus accumbens for mediating some of the stimulatory effects of nicotine on the reward-related mesoaccumbens dopamine system.
The role of angiogenic growth factors in organogenesis (2011)

Angiogenic growth factors are a class of molecules which exert a fundamental role in the process of blood vessel formation. Besides vasculogenic and angiogenic properties, these compounds mediate a complex series of patterning activities during organogenesis. Angiogenic factors cooperate in the growth and development of embryo tissues in a cross-talk between endothelial cells and tissue cells. It is well established that many tissue-derived factors are involved in blood vessel formation, but there is now emerging evidence that angiogenic factors and endothelial cells themselves represent a crucial source of instructive signals to non-vascular tissue cells during organ development. Thus, angiogenic factors and endothelial cell signalling are currently believed to provide fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodelling. This review article will summarize some of the recent advances in our understanding of the role of angiogenic factors and endothelial cells as effectors in organ formation.
Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. (1979)

Human promyelocytic leukemia cells (HL-60) were induced to differentiate into mature cells by the tumor-promoting agent phorbol-12-myristate-13-acetate and other related phorbol diesters. Differentiation was determined by an increase in the percent of myelocytes, metamyelocytes, and other mature myeloid cells as well as by an increase in the percent of phagocytizing cells. Induction of differentiation could be determined after 2 days of treatment with phorbol-12-myristate-13-acetate at a dose as low as 6 X 10(11) M. A correlation was found between reported tumor-promoting activity of a series of phorbol esters and their ability to induce myeloid differentiation and to inhibit cell growth. It is suggested that tumor-promoting agents like chemicals that induce terminal differentiation in these cells, at extremely low concentrations, may be used as a tool in the study of the control of cell growth, cell differentiation, and malignancy in human leukemic cells.
WPI Precision Personnel Locator System – Indoor Location Demonstrations and RF Design Improvements (2007)

This paper describes the latest developments in the Worcester Polytechnic Institute (WPI) Precision Personnel Locator (PPL) project. The RF-based PPL system is being developed for tracking of first responders and other personnel in indoor environments. The system assumes no existing infrastructure, no pre-characterization of the area of operation and is designed for spectral compliance. This paper concentrates on describing the effects of different bandwidths on tracking and location accuracy in a variety of building structures based upon tests of the full system in those environments. The paper also documents the results of substantial improvements in the location algorithm. Recent testing has shown submeter positioning accuracy of a transmitter even in difficult indoor environments with high multi-path despite all receivers being placed outside the building. The current system has demonstrated accuracies of approximately 0.5m in real building environments. Results to date have been achieved with a 60 MHz wide multi-carrier signal from 410 to 470 MHz. The RF transmitter and receiver hardware are currently being upgraded to allow operation in the 550 to 700 MHz region. A description and initial bench tests of the new RF hardware are included.
Blood Reflux in Schlemm's Canal (1979)

Blood may be refluxed into Schlemm's canal in the normal eye by occlusion of recipient veins in a sector of the conjunctiva and episclera. The blood makes the anterior margin of the canal distinct near the midportion of the trabecular mesh at the same place in which it is seen after hypotony. Circumferential flow in segments of the canal is possible when a pressure head exists to promote such flow. Evidence was found that the canal is not partially collapsed in the normal eye.
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53 (2007)

The transcriptional coactivator p300 binds to and mediates the transcriptional functions of the tetrameric tumor suppressor p53. Both proteins consist of independently folded domains linked by intrinsically disordered sequences. A well studied short sequence of the p53 transactivation domain, p53(15-29), binds weakly to four folded domains of p300 [Taz1/cysteine-histidine-rich region 1 (CH1), Kix, Taz2/CH3, IBiD], with dissociation constants (K(D)) in the 100 muM region. However, we found that a longer N-terminal transactivation domain construct p53(1-57) bound tightly to each p300 domain. Taz2/CH3 had the greatest affinity (K(D) = 27 nM) and competes with the N-terminal domain of Mdm2 for the p53 N terminus. p300 thus can protect the N terminus of p53 against the binding of other proteins. Mutations of p53 that abrogate transactivation (L22Q/W23S, W53Q/F54S) greatly weakened binding to each p300 domain, linking phenotypic defects to weakened coactivator binding. We propose a complex between tetrameric p53 and p300 in which four domains of p300 wrap around the four transactivation domains of p53.
EXAMINATION OF SINGLE VEHICLE ROADWAY DEPARTURE CRASHES AND POTENTIAL IVHS COUNTERMEASURES. FINAL REPORT (1994)

The report provides an analysis of single vehicle roadway departure (SVRD) crashes to guide the development of Intelligent Vehicle Highway Systems (IVHS) crash avoidance systems. It introduces the problem of SVRD crashes: a crash is defined as a SVRD when the first harmful event is the departure from the roadway, thus excluding departures resulting from prior impacts. Two crash subtypes are identified and casual factors that contribute to SVRD crashes are assessed clinically from a sample of SVRD crashes. From these data, functional goals for IVHS SVRD crash avoidance systems are described.
Optical and electrical diagnostics of a non-equilibrium air plasma (2003)

An AC-driven, non-equilibrium, atmospheric pressure air plasma is generated within the gap separating a disc-shaped metal electrode and a water electrode. The typical OH emission intensity distribution is recorded by high-speed CCD camera. The temporal emission behaviour of OH(A–X) shows that the OH emission intensity stays relatively constant during most of the current cycle but decreases abruptly when the current is close to zero. The N2 rotational and vibrational temperatures are obtained by comparison of the simulated spectra of C 3Π u–B 3Πg (Δv = −2) band transition of nitrogen with the experimental results. They are about 1800 K and 2600 K, respectively. The electron density in the plasma is measured utilizing the electrical conductivity. It is found to be 7 × 1012 cm−3 in the centre of the discharge during the peak current of Ipeak = 40 mA. The electron density follows a Gaussian radial distribution with a typical width of 0.35 mm.
Fast Monomers:  Factors Affecting the Inherent Reactivity of Acrylate Monomers in Photoinitiated Acrylate Polymerization (2003)

A systematic study on the effect of molecular structure on the photoinitiated polymerization of acrylates was undertaken. Initially, the research was focused on the effect of hydrogen bonding, and it was found that preorganization via hydrogen bonding enhances the maximum rate of polymerization (Rp). This hydrogen bonding facilitated preorganization also affected the tacticity of the resultant polymer. Next, the effect of polarity as represented by the calculated dipole moment (μcalc) of a given monomer was investigated. A direct linear correlation between Rp and the calculated Boltzmann-averaged dipole moment (μcalc) was observed. The Rp−μcalc correlation holds for pure monomers, mixtures of monomers, and even mixtures of monomers with inert solvents. This correlation enables the rational design of monomers with a required reactivity. In addition, these studies suggest that the propagation step of polymerization is influenced by hydrogen bonding while the dipole moment influences the termination rate constant. These two mechanistic explanations can be regarded as complementary factors that influence the speed of acrylate polymerization.
Molecular analysis of beta zero-thalassemia intermedia in Sardinia (1989)

In this study we have carried out alpha- and beta-globin gene analysis and defined the beta-globin gene polymorphisms in a group of patients with thalassemia intermedia of Sardinian descent. A group of patients (109) with thalassemia major of the same origin served as control. Characterization of the beta-thalassemia mutation showed either a frameshift mutation at codon 6 or a codon 39 nonsense mutation. We found that homozygotes for the frameshift mutation at codon 6 or compound heterozygotes for this mutation and for the codon 39 nonsense mutation develop thalassemia intermedia more frequently than thalassemia major. The frameshift mutation at codon 6 was associated with haplotype IX that contains the C-T change at position -158 5′ to the G gamma globin gene implicated in high gamma chain production and thus the mild phenotype. In patients' homozygotes for codon 39 nonsense mutation, those with thalassemia intermedia more frequently had the two- gene deletion form of alpha-thalassemia, or functional loss of the alpha 2 gene as compared with those with thalassemia major. In a few siblings with thalassemia major and intermedia, the thalassemia intermedia syndrome correlated with the presence of the -alpha/-alpha genotype. No cause for the mild phenotype was detected in the majority of patients who had not inherited either haplotype IX or alpha- thalassemia.
Communications: Response of First-Feeding Spring Chinook Salmon to Four Potential Chemical Modifiers of Feed Intake (1991)

Abstract The feed intake of first-feeding spring chinook salmon (Oncorhynchus tshawytscha) changed significantly when the amino acid glycine or the ammonium-containing trimethylamine was added to experimental diets in a 2-week feeding trial. Glycine enhanced feed consumption, whereas trimethylamine (which occurs in rancid fish meals and oils) decreased it. This effect of trimethylamine may indicate that the fish were sensitive to it as an indicator of the freshness of their feed; this possible sensitivity may play a role in the apparent aversion that salmonids and other fish show toward highly oxidized meals and oils.
Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography (2006)

We present a moving-scatterer-sensitive optical Doppler tomography (MSS-ODT) technique for in vivo blood flow imaging in real time by using a spectral-domain optical coherence tomography system. In MSS-ODT the influence of stationary scatterers is suppressed by subtracting adjacent complex axial scans before calculating the Doppler frequency shift. We demonstrate that MSS-ODT is a useful technique for accurate determination of blood vessel size by imaging flow in a small capillary tube with a 75 microm inner diameter. The flow profile obtained with MSS-ODT yields a substantially more accurate tube diameter than that obtained with the conventional phase-resolved method, which underestimates the diameter by about 23%. We also demonstrate that MSS-ODT provides improved sensitivity over the conventional phase-resolved method for imaging in vivo blood flow in small vessels in a mouse ear.
Nonreciprocal Photon Transmission and Amplification via Reservoir Engineering (2015)

Nonreciprocal photonic systems allow for the unidirectional transmission and amplification of photons, which enables a host of applications. A new and general approach for realizing nonreciprocal interactions shows how they can be used to construct quantum-limited amplifiers and isolators.
Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories (2009)

Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pressure, caused by subarachnoid space (SAS) flow blockage (stenosis), is an underlying cause of syrinx formation and subsequent pain in the patient. However, paucity in detailed in vivo pressure data has made theoretical explanations for the syrinx difficult to reconcile. In order to understand the complex pressure environment, four simplified in vitro models were constructed to have anatomical similarities with post-traumatic SM and Chiari malformation related SM. Experimental geometry and properties were based on in vivo data and incorporated pertinent elements such as a realistic CSF flow waveform, spinal stenosis, syrinx, flexible SC, and flexible spinal column. The presence of a spinal stenosis in the SAS caused peak-to-peak cerebrospinal fluid CSF pressure fluctuations to increase rostral to the stenosis. Pressure with both stenosis and syrinx present was complex. Overall, the interaction of the syrinx and stenosis resulted in a diastolic valve mechanism and rostral tensioning of the SC. In all experiments, the blockage was shown to increase and dissociate SAS pressure, while the axial pressure distribution in the syrinx remained uniform. These results highlight the importance of the properties of the SC and spinal SAS, such as compliance and permeability, and provide data for comparison with computational models. Further research examining the influence of stenosis size and location, and the importance of tissue properties, is warranted.
A CMR study of the effects of tissue edema and necrosis on left ventricular dyssynchrony in acute myocardial infarction: implications for cardiac resynchronization therapy (2012)

In the acute phase of infarction, LV dyssynchrony is closely related to the extent of edema, while necrosis is a poor predictor of acute LV dyssynchrony. Conversely, regression of intraventricular LV dyssynchrony during infarct healing is predicted by the extent of necrosis in the acute phase.
Comparison of nucleotide and deduced amino acid sequence of the 5' non-coding region and structural protein genes of the wild-type Japanese encephalitis virus strain SA14 and its attenuated vaccine derivatives (1994)

Nucleotide sequences of the 5' non-coding region and the structural protein genes of the live, attenuated Japanese encephalitis vaccine virus strains SA14-2-8 and SA14-5-3 and the wild-type parental strain SA14/USA were determined. SA14-2-8 differed from SA14/USA by 13 nucleotides and eight amino acids whereas SA14-5-3 differed from SA14/USA by 15 nucleotides and eight amino acids. A comparison of the 5' non-coding region and amino acid sequences of the structural proteins of these two attenuated vaccine strains and of vaccine strains SA14-14-2/PHK and SA14-14-2/PDK with three sequences of their wild-type parent SA14 virus was performed. This revealed only two common amino acid substitutions at positions 138 and 176 in the envelope (E) protein. The substitution at E138 was predicted to cause a change in the secondary structure of the E protein. These two amino acid substitutions in the E protein may contribute to attenuation of the Japanese encephalitis vaccine viruses.
A New Solution to Coherence Problems in Multicache Systems (1978)

A memory hierarchy has coherence problems as soon as one of its levels is split in several independent units which are not equally accessible from faster levels or processors. The classical solution to these problems, as found for instance in multiprocessor, multicache systems, is to restore a degree of interdependence between such units through a set of high speed interconnecting buses. This solution is not entirely satisfactory, as it tends to reduce the throughput of the memory hierarchy and to increase its cost.
Nucleotide Sequence-Based Multitarget Identification (2003)

MULTIGEN technology (T. Vinayagamoorthy, U.S. patent 6,197,510, March 2001) is a modification of conventional sequencing technology that generates a single electropherogram consisting of short nucleotide sequences from a mixture of known DNA targets. The target sequences may be present on the same or different nucleic acid molecules. For example, when two DNA targets are sequenced, the first and second sequencing primers are annealed to their respective target sequences, and then a polymerase causes chain extension by the addition of new deoxyribose nucleotides. Since the electrophoretic separation depends on the relative molecular weights of the truncated molecules, the molecular weight of the second sequencing primer was specifically designed to be higher than the combined molecular weight of the first sequencing primer plus the molecular weight of the largest truncated molecule generated from the first target sequence. Thus, the series of truncated molecules produced by the second sequencing primer will have higher molecular weights than those produced by the first sequencing primer. Hence, the truncated molecules produced by these two sequencing primers can be effectively separated in a single lane by standard gel electrophoresis in a single electropherogram without any overlapping of the nucleotide sequences. By using sequencing primers with progressively higher molecular weights, multiple short DNA sequences from a variety of targets can be determined simultaneously. We describe here the basic concept of MULTIGEN technology and three applications: detection of sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum), detection of contaminants in meat samples (coliforms, fecal coliforms, and Escherichia coli O157:H7), and detection of single-nucleotide polymorphisms in the human N-acetyltransferase (NAT1) gene (S. Fronhoffs et al., Carcinogenesis 22:1405-1412, 2001).
Tumor Necrosis Factor-α Mediates Oligodendrocyte Death and Delayed Retinal Ganglion Cell Loss in a Mouse Model of Glaucoma (2006)

Glaucoma is a widespread ocular disease characterized by a progressive loss of retinal ganglion cells (RGCs). Previous studies suggest that the cytokine tumor necrosis factor-alpha (TNF-alpha) may contribute to the disease process, although its role in vivo and its mechanism of action are unclear. To investigate pathophysiological mechanisms in glaucoma, we induced ocular hypertension (OH) in mice by angle closure via laser irradiation. This treatment resulted in a rapid upregulation of TNF-alpha, followed sequentially by microglial activation, loss of optic nerve oligodendrocytes, and delayed loss of RGCs. Intravitreal TNF-alpha injections in normal mice mimicked these effects. Conversely, an anti-TNF-alpha-neutralizing antibody or deleting the genes encoding TNF-alpha or its receptor, TNFR2, blocked the deleterious effects of OH. Deleting the CD11b/CD18 gene prevented microglial activation and also blocked the pathophysiological effects of OH. Thus TNF-alpha provides an essential, although indirect, link between OH and RGC loss in vivo. Blocking TNF-alpha signaling or inflammation, therefore, may be helpful in treating glaucoma.
A pulsed UWB receiver SoC for insect motion control (2009)

This paper presents a pulsed ultrawideband (UWB) RX SoC designed for the stringent weight, volume and power constraints of the cyborg moth system.
Design and implementation of a fibre channel network driver for SAN-attached RAID controllers (2002)

Fibre channel SAN (storage area network) is considered to be a promising solution to address storage problems caused by the sheer volume of data and their management. To adopt this new storage environment, we design and implement a high performance fibre channel network driver for SAN-attached RAID controllers in a real-time operating system. We describe the architecture of the fibre channel driver which consists of two modes; a target mode and an initiator mode. An exception handling mechanism for enduring a disk failure is also given. Lastly, we measured the performance of the fibre channel driver. Testing results reveal a moderately successful performance of the fibre channel driver.
Fast execution of loops with if statements (1984)

In this paper we show how to execute in parallel loops containing IF statements. We give an architectural model of parallel computation and describe the design of a hardware Boolean Recurrence Solver. Our method of handling such loops is then compared with those used by some of the existing supercomputers.