gebhart/patrepeval huggingface dataset:
Polymerization of Nonlamellar Lipid Assemblies (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymerization of Nonlamellar Lipid AssembliesYoun-Sik Lee, Jian-Zhong Yang, Thomas M. Sisson, David A. Frankel, James T. Gleeson, Emre Aksay, Sarah L. Keller, Sol M. Gruner, and David F. O'BrienCite this: J. Am. Chem. Soc. 1995, 117, 20, 5573–5578Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ja00125a019https://doi.org/10.1021/ja00125a019research-articleACS PublicationsRequest reuse permissionsArticle Views466Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Invisibility coherence for faster scan-line hidden surface algorithms (1984)

Invisibility coherence is a new technique developed to decrease the time necessary to render shaded images by existing scan-line hidden surface algorithms. Invisibility coherence is a technique for removing portions of a scene that are not likely to be visible. If a large portion of the scene is invisible, as is often the case in three-dimensional computer graphics, the processing time eliminated may be substantial. Invisibility coherence takes advantage of the observation that a minimal amount of processing needs to be done on objects (polygons, patches, or surfaces) that will be hidden by other objects closer to the viewer. This fact can be used to increase the efficiency of current scan-line algorithms, including both polygon-based and parametrically curved surface-based algorithms. Invisibility coherence was implemented and tested with the polygon hidden surface algorithm for constructive solid geometry developed by Peter Atherton [1]. The use of invisibility coherence substantially increases the efficiency of this scan-line algorithm. Invisibility coherence should work as well or even better with other scan-line hidden surface algorithms, such as the Lane-Carpenter, Whitted, and Blinn algorithms for parametrically curved surfaces [2]., or the Watkins, Romney, and Bouknight algorithms for polygons [3, 4, 5].
The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden (2011)

Tumor burden affects the in vivo mechanism of action of CD20 antibodies. Low tumor load can be eliminated by complement alone, whereas elimination of high tumor load requires multiple effector mechanisms.
Bevacizumab treatment in the elderly patient with&nbsp;metastatic colorectal cancer (2015)

Metastatic colorectal cancer (mCRC), like many cancers, is primarily a disease of elderly people. Despite this prevalence, such patients are often excluded from randomized trials or represent a minority of enrolled patients. Moreover, the criteria for establishing benefit or side effects of treatment strategies in this population are uncertain and not well recognized. Bevacizumab improves the outcome of mCRC when used in combination with standard first-line and second-line chemotherapy and beyond the first disease progression when given with a chemotherapy backbone different from that used in the precedent line. The particular toxicity profile of this antiangiogenesis agent (in particular hypertension, thromboembolic events, hemorrhage, and renal failure) may discourage its use in elderly patients with comorbidities. Data from subgroup analyses of randomized trials and the results of recent cohort studies suggest a significant benefit from the addition of bevacizumab to standard chemotherapy for elderly patients comparable with that observed in younger patients, except for the increased risk for thromboembolic events. Age alone should not be a barrier to use of bevacizumab, and further research with a more complete geriatric assessment should investigate the role of bevacizumab in elderly patients with mCRC to avoid undertreatment of this patient population due to a historical conservative approach.
Systemic Administration of Agonist Peptide Blocks the Progression of Spontaneous CD8-Mediated Autoimmune Diabetes in Transgenic Mice Without Bystander Damage (2000)

Insulin-dependent diabetes is an autoimmune disease targeting pancreatic beta-islet cells. Recent data suggest that autoreactive CD8+ T cells are involved in both the early events leading to insulitis and the late destructive phase resulting in diabetes. Although therapeutic injection of protein and synthetic peptides corresponding to CD4+ T cell epitopes has been shown to prevent or block autoimmune disease in several models, down-regulation of an ongoing CD8+ T cell-mediated autoimmune response using this approach has not yet been reported. Using CL4-TCR single transgenic mice, in which most CD8+ T cells express a TCR specific for the influenza virus hemagglutinin HA512-520 peptide:Kd complex, we first show that i.v. injection of soluble HA512-520 peptide induces transient activation followed by apoptosis of Tc1-like CD8+ T cells. We next tested a similar tolerance induction strategy in (CL4-TCR x Ins-HA)F1 double transgenic mice that also express HA in the beta-islet cells and, as a result, spontaneously develop a juvenile onset and lethal diabetes. Soluble HA512-520 peptide treatment, at a time when pathogenic CD8+ T cells have already infiltrated the pancreas, very significantly prolongs survival of the double transgenic pups. In addition, we found that Ag administration eliminates CD8+ T cell infiltrates from the pancreas without histological evidence of bystander damage. Our data indicate that agonist peptide can down-regulate an autoimmune reaction mediated by CD8+ T cells in vivo and block disease progression. Thus, in addition to autoreactive CD4+ T cells, CD8+ T cells may constitute targets for Ag-specific therapy in autoimmune diseases.
The Effect of Local Application of 1,25-Dihydroxycholecalciferol on Osteoclast Numbers in Orthodontically Treated Rats (1992)

Orthodontic tooth movement requires remodeling of periodontal tissues, especially alveolar bone. 1,25-(OH)2D3, the active form of vitamin D3, is known to be a potent stimulator of osteoclastic bone resorption. The purpose of this study was to investigate the effect of local application of 1,25-(OH)2D3 on osteoclast numbers induced by experimental tooth movement. A piece of orthodontic elastic band was inserted between the first and second upper molars of male Wistar rats weighing about 200 g each. Twenty microL of 1,25-(OH)2D3 (10(-12)-10(-7) mol/L) was injected locally into the submucosal palatal area of the root bifurcation of the right first molar. The left side was injected with phosphate-buffered saline (PBS). The number of osteoclasts was counted in a 700 x 1050 microns 2 area of the interradicular septum. The local injection of 1,25-(OH)2D3 caused a dose-dependent increase in osteoclast number. The effect of 1,25-(OH)2D3 reached a response plateau at 10(-10) mol/L when greater than a three-fold rise in osteoclast number was attained compared with the PBS-treated controls. While the insertion of a piece of elastic band for three days induced a significant increase in osteoclasts in the alveolar bone, daily injections of 20 microL of 10(-10) mol/M 1,25-(OH)2D3 for three days markedly stimulated the numbers of osteoclasts induced by the insertion of an elastic band. 1,25-(OH)2D3 was apparently synergistic with mechanical stimuli, resulting in enhancement of the numbers of osteoclasts induced by mechanical stimuli alone.(ABSTRACT TRUNCATED AT 250 WORDS)
Hypercalcemia induced with an arotinoid in thyroparathyroidectomized rats. New model to study bone resorption in vivo. (1987)

A model of stimulated bone resorption was developed using a synthetic retinoid in thyroparathyroidectomized rats. The retinoid induced an increase in bone resorption and in the number of vertebral subperiosteal osteoclasts. The resulting increase in plasma Ca could be used as an easily measured index of bone resorption. Three bisphosphonates produced a dose-related prevention and reversal of retinoid-induced hypercalcemia. Their potencies were similar to those previously obtained by histomorphometry. Irradiation (600 rad) of the rats prevented hypercalcemia but failed to reverse it, showing that proliferation of osteoclast precursor cells was important in inducing, but not in maintaining, bone resorption. Calcitonin produced similar effects on calcemia and prevented the increase in osteoclast number but failed to reverse the increase, suggesting that it inhibited precursor proliferation. This model represents a new tool to study mechanisms of bone resorption and the action of inhibitors in vivo.
Antifreeze Proteins in Winter Rye Are Similar to Pathogenesis-Related Proteins (1995)

The ability to control extracellular ice formation during freezing is critical to the survival of freezing-tolerant plants. Antifreeze proteins, which are proteins that have the ability to retard ice crystal growth, were recently identified as the most abundant apoplastic proteins in cold-acclimated winter rye (Secale cereale L.) leaves. In the experiments reported here, amino-terminal sequence comparisons, immuno-cross-reactions, and enzyme activity assays all indicated that these antifreeze proteins are similar to members of three classes of pathogenesis-related proteins, namely, endochitinases, endo-beta-1,3-glucanases, and thaumatin-like proteins. Apoplastic endochitinases and endo-beta-1,3-glucanases that were induced by pathogens in freezing-sensitive tobacco did not exhibit antifreeze activity. Our findings suggest that subtle structural differences may have evolved in the pathogenesis-related proteins that accumulate at cold temperatures in winter rye to confer upon these proteins the ability to bind to ice.
Interdiffusion in Polyelectrolyte Multilayers (2010)

Using neutron reflectivity, the internal structure of polyelectrolyte multilayers is described on the nanoscale. Each film consists of a protonated and a deuterated block, built from x protonated and y deuterated polycation/polyanion bilayers, respectively. The number of bilayers N = x + y is kept constant; the position of the interface between the blocks is varied systematically. The polyanion is poly(styrenesulfonate) (PSS), and the polycation is poly(allylamine hydrochloride) (PAH) or poly(diallyldimethylammonium chloride) (PDADMAC). Always, the first four to five bilayers are thinner than the average bilayer thickness, but the three terminating bilayers are sometimes thicker. In the core zone, the bilayer thickness is constant. The internal roughness is smallest next to the film/air interface and increases with the number of bilayers away from the film/air interface. This suggests that each deposition step promotes the interdiffusion of the supporting layers. At the selected preparation conditions, the internal roughness increases more for PDADMAC/PSS than for PAH/PSS; the diffusion constants differ by 2 orders of magnitude.
Effect of body structure on analog performance of SOI NMOSFET's (2002)

Summary form only given. Recently, SOI devices have been applied to high performance mixed analog/digital or analog circuits. SOI devices with a modified structure were investigated for analog applications (Chan et al, 1995). We have studied the effect of body structure on analog performance of SOI NMOSFETs. The body structures are lateral body-floating (without body contact), lateral body-tied, and vertical body-tied, respectively. Three device structures are fabricated on the same wafer by wafer bonding and etch-back technology. Key analog parameters such as g/sub m/r/sub o/ and 1/f noise are measured and compared. The lateral body-tied device shows the lowest 1/f noise spectral density. The vertical body-tied SOI device has the best g/sub m/r/sub o/ characteristics at V/sub DS/ of 3 V and I/sub D/ of 10 /spl mu/A. We also showed the g/sub m/r/sub o/ characteristics of vertical body-tied SOI devices with different boron implantation dose for doping of the buried polysilicon body electrode.
Increasing Utilization in Modern Warehouse-Scale Computers Using Bubble-Up (2012)

Precisely predicting performance degradation due to colocating multiple executing applications on a single machine is critical for improving utilization in modern warehouse-scale computers (WSCs). Bubble-Up is the first mechanism for such precise prediction. As opposed to over-provisioning machines, Bubble-Up enables the safe colocation of multiple workloads on a single machine for Web service applications that have quality of service constraints, thus greatly improving machine utilization in modern WSCs.
Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma (2004)

CMC-544 confers strong therapeutic activity against systemic disseminated B-cell lymphoma and protects mice from hind-limb paralysis and death. These results support clinical evaluation of CMC-544 in the treatment of CD22+ lymphoid malignancies.
Persistence of Epstein-Barr virus in salivary gland biopsies from healthy individuals and patients with Sjögren's syndrome. (1989)

Salivary gland biopsies from 12 patients with primary Sjögren's syndrome and 10 controls were examined for Epstein-Barr virus (EBV) DNA by in-situ hybridization and for EBV proteins by immunofluorescence and peroxidase techniques. Viral DNA was found in biopsies from two out of 12 patients with primary Sjögren's syndrome and six out of the 10 controls. The DNA and early antigen were in epithelial cells lining the ducts and acini, early antigen expression being limited to the luminal side of the epithelium. In eight biopsies studied with other antibodies, membrane antigen was identified in both acini and ducts but viral capsid antigen and Epstein-Barr nuclear antigen were not detected. EBV was found in biopsies from five of the controls without inflammation or Class II expression. This suggests that, in health, persistence and replication occur without inducing an immune response, possibly due to the restricted expression of early antigen on the luminal of the epithelium, away from immune surveillance. The inflammation in Sjögren's syndrome could be due to a breakdown of this unusual mechanism for viral persistence leading to a vigorous immune response to the virus. However our study provides no evidence to suggest that EBV infection load is increased in this disease.
Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. (1991)

To assess the role of different types of antigen-presenting cells (APC) in the induction of tolerance, we isolated B cells, macrophages, and dendritic cells from thymus and spleen, and injected these into neonatal BALB/c mice across an Mls-1 antigenic barrier. One week after injection of APC from Mls-1-incompatible mice or from control syngeneic mice, we measured the number of thymic, Mls-1a-reactive, V beta 6+ T cells and the capacity of thymocytes to induce a graft-vs.-host (GVH) reaction in popliteal lymph nodes of Mls-1a mice. Injection of thymic but not spleen B cells deleted thymic, Mls-1a-reactive V beta 6+ T cells and induced tolerance in the GVH assay. The thymic B cells were primarily of the CD5+ type, and fluorescence-activated cell sorter-purified CD5+ thymic B cells were active. Injection of dendritic cells from spleen or thymus also induced tolerance, but the V beta 6 cells were anergized rather than deleted. Macrophages from thymus did not induce tolerance. Dendritic cells and thymic B cells were also effective in inducing tolerance even when injected into Mls-, major histocompatibility complex-incompatible, I-E- mice, but only thymic B cells depleted V beta 6-expressing T cells. Therefore, different types of bone marrow-derived APC have different capacities for inducing tolerance, and the active cell types (dendritic cells and CD5+ thymic B cells) can act by distinct mechanisms.
Laminin abnormality in severe childhood autosomal recessive muscular dystrophy. (1995)

The expression of laminin is greatly disturbed in severely diseased SCARMD muscle deficient in adhalin. Disturbance of sarcolemma-basal lamina interaction may play an important role in the molecular pathogenesis of muscle fiber necrosis in SCARMD.
Real-Time Stochastic Detection of Multiple Neurotransmitters with a Protein Nanopore (2012)

The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.
Antisense and Antigene Inhibition of Gene Expression by Cell-Permeable Oligonucleotide–Oligospermine Conjugates (2011)

Oligonucleotides and their derivatives are a proven chemical strategy for modulating gene expression. However, their negative charge remains a challenge for delivery and target recognition inside cells. Here we show that oligonucleotide-oligospermine conjugates (Zip nucleic acids or ZNAs) can help overcome these shortcomings by serving as effective antisense and antigene agents. Conjugates containing DNA and locked nucleic acid (LNA) oligonucleotides are active, and oligospermine conjugation facilitates carrier-free cell uptake at nanomolar concentrations. Conjugates targeting the CAG triplet repeat within huntingtin (HTT) mRNA selectively inhibit expression of the mutant huntingtin protein. Conjugates targeting the promoter of the progesterone receptor (PR) function as antigene agents to block PR expression. These observations support further investigation of ZNA conjugates as gene silencing agents.
Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice (2002)

In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A major therapeutic strategy aims to decrease production of amyloid peptides by inhibition of gamma-secretase. Presenilins are polytopic transmembrane proteins that are essential for gamma-secretase activity during development and in amyloid production. By loxP/Cre-recombinase-mediated deletion, we generated mice with postnatal, neuron-specific presenilin-1 (PS1) deficiency, denoted PS1(n-/-), that were viable and fertile, with normal brain morphology. In adult PS1(n-/-) mice, levels of endogenous brain amyloid peptides were strongly decreased, concomitant with accumulation of amyloid precursor protein (APP) C-terminal fragments. In the cross of APP[V717I]xPS1 (n-/-) double transgenic mice, the neuronal absence of PS1 effectively prevented amyloid pathology, even in mice that were 18 months old. This contrasted sharply with APP[V717I] single transgenic mice that all develop amyloid pathology at the age of 10-12 months. In APP[V717I]xPS1 (n-/-) mice, long-term potentiation (LTP) was practically rescued at the end of the 2 hr observation period, again contrasting sharply with the strongly impaired LTP in APP[V717I] mice. The findings demonstrate the critical involvement of amyloid peptides in defective LTP in APP transgenic mice. Although these data open perspectives for therapy of AD by gamma-secretase inhibition, the neuronal absence of PS1 failed to rescue the cognitive defect, assessed by the object recognition test, of the parent APP[V717I] transgenic mice. This points to potentially detrimental effects of accumulating APP C99 fragments and demands further study of the consequences of inhibition of gamma-secretase activity. In addition, our data highlight the complex functional relation of APP and PS1 to cognition and neuronal plasticity in adult and aging brain.
The 160-Kilobase Genome of the Bacterial Endosymbiont Carsonella (2006)

Previous studies have suggested that the minimal cellular genome could be as small as 400 kilobases. Here, we report the complete genome sequence of the psyllid symbiont Carsonella ruddii, which consists of a circular chromosome of 159,662 base pairs, averaging 16.5% GC content. It is by far the smallest and most AT-rich bacterial genome yet characterized. The genome has a high coding density (97%) with many overlapping genes and reduced gene length. Genes for translation and amino acid biosynthesis are relatively well represented, but numerous genes considered essential for life are missing, suggesting that Carsonella may have achieved organelle-like status.
Preliminary investigation of micropumping based on electrical control of interfacial tension (2002)

Electrical control of the interfacial tension between a liquid and solid (electrowetting) is studied as a means of microactuation for fluid systems, i.e. micropumping Electrowetting provides a means of direct fluid pumping with no moving mechanical parts, which may prove useful in a number of application areas, such as micro chemical dispensers, injectors, and reactors, and even cooling systems for high-density microelectronics. A test device has been built (with silicon micromachining) for the study of electrowetting, and a detailed model of the devices is given. The model describes liquid flow in a small channel, as governed by Navier-Stokes equations, Laplace's equation, Young's equation, and Lippmann's equation. Simulation results presented indicate that electrowetting is a viable approach to microactuation: in a 10 mu m radius channel, it may be used to generate pressures on the order of 0.01 MPa, comparable to pressures generated by existing micropump designs are order of magnitude larger in size. Although the dynamics of the test device are dominated by fluid friction, it is also shown that another micropump design, based on mercury, should behave as a nearly frictionless oscillator.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Biological Hydrogen Production by Strict Anaerobic Bacteria: Fundamentals, Operational Strategies, and Limitations (2008)

This chapter contains sections titled: Introduction Dark fermentation Operating parameters affecting hydrogen production Challenges of the reactor operation Practical limitation Conclusions References
Subjective and objective performance of the Lenstec KH-3500 "accommodative" intraocular lens (2006)

The objective accommodating effects of the KH-3500 IOL appear to be limited, although the subjective and objective accommodative range is significantly increased compared to control subjects implanted with conventional IOLs. However, this "accommodative" ability of the lens appears to have decreased by 6 months post-surgery.