gebhart/patrepeval huggingface dataset:
B-cell Depletion Using an Anti-CD20 Antibody Augments Antitumor Immune Responses and Immunotherapy in Nonhematopoetic Murine Tumor Models (2008)

The role played by B cells in cancer biology is complex and somewhat controversial. Previous studies using genetically engineered mice suggest that B cells may be immunosuppressive and inhibit tumor rejection. However, the effects of B-cell depletion employing an antibody in mice bearing solid tumors has not been tested owing to difficulties in making an effective antimouse CD20 antibody (similar to rituximab). Injection of a newly developed antimouse CD20 antibody was effective in depleting circulating B cells from blood and lymph nodes, although depletion was less complete in the spleen. B-cell depletion slowed the growth of new solid tumors (not expressing CD20) and retarded the growth of established tumors but did not induce tumor regression. However, when the antibody was combined with an active immunotherapy approach using an adenovirus vaccine expressing the human papilloma virus-E7 gene (Ad.E7) in mice bearing TC1 tumors (murine lung cancer cells expressing human papilloma virus-E7), we noted enhanced antitumor effects and increased numbers of tetramer+/CD8+ T cells within the spleens and activated CD8+ T cells within tumors. B-cell depletion using an anti-CD20 antibody was thus effective in retarding tumor growth in multiple solid tumor models and augmenting immunotherapy in a tumor vaccine model. These studies raise the possibility that B-cell depletion may be a useful adjunct in human immunotherapy trials.
Overview of advances in sugar‐based polymers (2010)

Abstract Polymeric biomaterials, especially agricultural commodity‐based polymers, have been moving forward quickly during the last few years because of the significant rise in oil and natural gas prices. From a life‐cycle perspective, sugar is a renewable resource that has the potential to be used as an alternative to petroleum‐based polymers. The objective of this work is to demonstrate the wide utility of a cereal‐derived material, isosorbide, for high added value applications in polymers. As a bicyclic ether derivative of glucose, isosorbide is classified by the Food and Drug Administration as a “generally recognized as safe” (GRAS) material. Because of its rigidity, chirality, and nontoxicity, isosorbide can be incorporated into thermosets and thermoplastics. Such processes and products offer a more sustainable and “green” technology. By making the diglycidyl ether, isosorbide epoxy resins were synthesized in this work as a new class of thermosets with comparable dry mechanical property similar to bisphenol A (BPA) epoxide. These could be a potential replacement for BPA in coatings and adhesives. By controlling the stereochemistry, multiple isosorbide‐derived AB monomers such as isosorbide methyl terephthalate were synthesized for future homopolymerization and copolymerizations with commercial available polymers like polyethylene terephthalate (PET) and PLLA. The increased glass transition temperature and semicrystalline morphology of these isosorbide copolyesters demonstrate a way to improve the performance of polyester thermoplastics in many applications such as hot‐fill containers and engineering resins. All the intermediates generated during the syntheses were characterized by NMR. The thermal tests were conducted using the techniques of DSC and thermogravimetric analysis (TGA). Copyright © 2010 John Wiley &amp; Sons, Ltd.
PAROXYSMAL FUSSING IN INFANCY, SOMETIMES CALLED "COLIC" (1954)

The literature on "infantile colic" or "paroxysmal fussing" is reviewed. The frequent occurrence of a regular evening fussy period in two groups of infants is reported as indicative that this is a normal physiological event of the first few weeks of life. The longitudinal records of 98 infants who were study subjects of the Yale Rooming-In Project were analyzed with respect to incidence, duration, and severity of "paroxysmal fussing." Forty-eight of the infants were classified as "fussy" and 50 as "contented." The "fussy" babies typically began to have their paroxysms in the second week of life and ceased to have them at about eight weeks. Almost all of them were more fussy in the evening hours than in the morning. The rationale of various methods of treatment is discussed. The "fussy" group was similar to the "contented" group as regards details of feeding, birth weight, weight gain, sex, educational level of the mother, and family history of allergy. Of the 48 "fussy" infants, family tension was judged to be an important contributing cause in 22 cases, allergy in six cases; both allergy and family tension together in nine cases; in 11 cases there was no apparent cause. "Paroxysmal fussing" or "infantile colic" is possibly one of the earliest somatic responses to the presence of tension in the environment. The particular degree to which any infant reacts is probably determined by constitutional factors.
Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura (1991)

Natural killer (NK) cell activity was studied in 17 patients with primary chronic idiopathic autoimmune thrombocytopenic purpura (ATP). Fifteen of 17 patients had a significantly reduced NK cytotoxicity against 51chromium labeled K562 target cells (mean LU20% = 18 +/- 20 in patients versus 65 +/- 25 in controls, P less than 0.001). NK activity was also significantly reduced in all of six patients with secondary ATP as compared with normal controls (LU20% 28 +/- 15, respectively, P less than 0.005). The NK activity in both patient groups correlated with the duration of therapy being received (r = 0.60, P less than 0.001). Immunophenotypic analysis of peripheral blood mononuclear cells from patients with ATP revealed that CD8- cells bearing CD57 (HNK-1, Leu 7) and CD3- cells bearing CD56 (Leu 19) were quantitatively within the normal range. These findings indicate that patients with ATP have a functional defect in NK cytolytic activity.
Image mapping spectrometry: calibration and characterization (2012)

Image mapping spectrometry (IMS) is a hyperspectral imaging technique that simultaneously captures spatial and spectral information about an object in real-time. We present a new calibration procedure for the IMS as well as the first detailed evaluation of system performance. We correlate optical components and device calibration to performance metrics such as light throughput, scattered light, distortion, spectral image coregistration, and spatial/spectral resolution. Spectral sensitivity and motion artifacts are also evaluated with a dynamic biological experiment. The presented methodology of evaluation is useful in assessment of a variety of hyperspectral and multi-spectral modalities. Results are important to any potential users/developers of an IMS instrument and to anyone who may wish to compare the IMS to other imaging spectrometers.
55Mn Pulsed ENDOR Demonstrates That the Photosystem II “Split” EPR Signal Arises from a Magnetically-Coupled Mangano−Tyrosyl Complex (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXT55Mn Pulsed ENDOR Demonstrates That the Photosystem II "Split" EPR Signal Arises from a Magnetically-Coupled Mangano−Tyrosyl ComplexJeffrey M. Peloquin, Kristy A. Campbell, and R. David BrittView Author Information Department of Chemistry, University of California, Davis Davis, California 95616 Cite this: J. Am. Chem. Soc. 1998, 120, 27, 6840–6841Publication Date (Web):June 27, 1998Publication History Received9 April 1998Published online27 June 1998Published inissue 13 June 1998https://pubs.acs.org/doi/10.1021/ja981196uhttps://doi.org/10.1021/ja981196urapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views350Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cluster chemistry,Electron paramagnetic resonance spectroscopy,Membranes,Quantum mechanics,Transition metals Get e-Alerts
In vivo He-3 MR images of guinea pig lungs. (1996)

The authors imaged the lungs of live guinea pigs with hyperpolarized (HP) helium-3 as a magnetic resonance (MR) signal source. HP He-3 gas produced through spin exchange with rubidium metal vapor was delivered through an MR-compatible, small-animal ventilator. Two- and three-dimensional lung images acquired with ventilation-gated, radial k-space sampling showed complete ventilation of both lungs. All images were of high quality, demonstrating that HP He-3 allows high-signal-intensity MR imaging in living systems.
Formation of a p-type quantum dot at the end of an n-type carbon nanotube (2001)

We use field effect doping to study both electron- (n) and hole- (p) type conduction in a semiconducting carbon nanotube. We find that, in the n-type region, the ends of the tube remain p- type due to doping by the metal contacts. As a result, a p–n junction forms near the contact, creating a small, p-type quantum dot between the p–n junction and the contact. This zero-dimensional quantum dot at the end of a one-dimensional semiconductor is the reduced dimensional analog of the two-dimensional inversion layer that forms at the boundary of a gated three-dimensional semiconductor.
The challenges and opportunities of integrating the physical world and networked systems (2001)

This paper presents a vision of how to link entities in the real world with the networking infrastructure to create an integrated mobile computing environment. We describe the challenges and opportunities implied by that linkage, and outline the web-based approach that we have adopted towards them. 1
A gibberellin response complex in cereal alpha-amylase gene promoters. (1992)

The Amy32b gene is a representative member of a closely related family of alpha-amylase genes expressed under hormonal control in aleurone layers of barley grains. Transcription of this gene is induced by gibberellin (GA) and suppressed by abscisic acid. In this study, we functionally defined the promoter elements of the Amy32b gene that govern the developmental and hormonal control of its expression in aleurone. Two functionally distinct yet physically associated elements are essential: a gibberellin response element mediates regulation by GA and abscisic acid, and an Opaque-2 binding sequence (O2S) is thought to interact with a barley homolog of the maize endosperm-specific transcriptional regulator Opaque-2. An additional element CCTTTT, which with the O2S forms part of a canonical "endosperm box," is important in modulating the absolute level of expression of the Amy32b promoter, as is another separate, highly conserved element TATCCATGCAGTG.
A kinetic study on the decomposition of 5-hydroxymethylfurfural into levulinic acid (2006)

Levulinic acid (LA), accessible by the acid catalyzed degradation of biomass, is potentially a very versatile green intermediate chemical for the synthesis of various (bulk) chemicals for applications like fuel additives, polymers, and resin precursors. We report here a kinetic study on one of the key steps in the conversion of biomass to levulinic acid, i.e. the reaction of 5-hydroxymethylfurfural (HMF) to levulinic acid. The kinetic experiments were performed in a temperature window of 98–181 °C, acid concentrations between 0.05–1 M, and initial HMF concentrations between 0.1 and 1 M. The highest LA yield was 94% (mol/mol), obtained at an initial HMF concentration of 0.1 M and a sulfuric acid concentration of 1 M. The yield at full HMF conversion is independent of the temperature. An empirical rate expression for the main reaction as well as the side reaction to undesired humins was developed using the power law approach. Agreement between experimental and model data is good. The rate expressions were applied to gain insights into optimum process conditions for batch processing.
Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. (1992)

Cytokine-stimulated human osteosarcoma cells (MG-63) secrete several related chemotactic factors, including the neutrophil-activating protein interleukin 8 (IL-8) and the monocyte chemotactic protein (MCP)-1. We describe the isolation and characterization of two novel monocyte chemotactic factors from this tumor cell line. Although these proteins copurified with MCP-1 and IL-8 on heparin-Sepharose, they could be separated by cation-exchange fast protein liquid chromatography and reverse-phase high-performance liquid chromatography. The corresponding 7.5- and 11-kD proteins were NH2-terminally blocked but were identified by sequencing peptide fragments. They showed a primary structure mostly related to that of MCP-1 and were therefore designated MCP-2 and MCP-3, respectively. These molecules can be classified in a subfamily of proinflammatory proteins characterized by the conservation of cysteine residues. MCP-2 and MCP-3 are also functionally related to MCP-1 because they specifically attract monocytes, but not neutrophils, in vitro. The chemotactic potency (specific activity) was comparable for all three MCPs. Intradermal injection of these proteins in rabbits resulted in selective monocyte recruitment in vivo. Since tumor cells are good producers of leukocyte chemotactic factors, it could be questioned whether these molecules can indirectly control tumor growth by attracting leukocytes or whether they rather promote invasion by the secretion of proteases from the attracted cells.
The NF (Nuclear factor)‐κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1‐dependent apoptosis in human acute myeloid leukaemia cells (2010)

Interactions between the nuclear factor (NF)-κB inhibitor parthenolide and the pan-histone deacetylase inhibitors (HDACIs) vorinostat and LBH589 were investigated in human acute myeloid leukaemia (AML) cells, including primary AML blasts. Co-administration of parthenolide blocked HDACI-mediated phosphorylation/activation of IKK and RelA/p65 in association with increased JNK1 activation in various AML cell types. These events were accompanied by an increase in apoptosis in multiple AML cell lines (e.g. U937, HL-60, NB4, MV-4-11, and MOLM-13). Significantly, parthenolide also increased HDACI-mediated cell death in haematopoietic cells transduced with the MLL-MLLT1 fusion gene, which exhibit certain leukaemia-initiating cell characteristics, as well as primary AML blasts. Exposure to parthenolide/HDACI regimens clearly inhibited the growth of AML-colony-forming units but was relatively sparing toward normal haematopoietic progenitors. Notably, blockade of c-Jun N-terminal kinase (JNK) signalling by either pharmacological inhibitors or genetic means (e.g. dominant-negative JNK1 or JNK1 shRNA) diminished parthenolide/HDACI-mediated lethality. Moreover, dominant-negative MKK7, but not dominant-negative MKK4/SEK1, blocked JNK1 activation and apoptosis induced by parthenolide/HDACI regimens. Together, these findings indicate that parthenolide potentiates HDACI lethality in human AML cells through a process involving NF-κB inhibition and subsequent MKK7-dependent activation of the SAPK/JNK pathway. They also raise the possibility that this strategy may target leukaemic progenitor cells.
Psychosocial benefits of a cancer support group (1986)

Many clinicians use group support to reduce the psychosocial difficulties of persons with cancer. This study compared the long-term benefits of a thematic counseling model used both as a structure for group support and for counseling patients individually. The thematic model included eight counseling sessions focused on information about cancer and positive health strategies such as progressive relaxation, diet, and exercise. The psychosocial status of women newly diagnosed with gynecologic cancer was assessed before the counseling, immediately after counseling, and again 6 months later. The women who participated in thematic counseling were significantly less depressed and less anxious and had more knowledge of their illness, better relationships with care givers, fewer sexual difficulties, and more participation in leisure activities. Data confirmed the model to be equally helpful whether it was used as a structure for individual counseling or more cost-effective group counseling. This model is easily adaptable to the needs of persons with other forms of cancer.
Analysis of uncultured amniocytes by comparative genomic hybridization: a prospective prenatal study (2000)

Comparative genomic hybridization (CGH) is a new molecular cytogenetic technique which can detect and map whole and partial aneuploidies throughout a genomic specimen DNA without culturing specimen cells. Thus, CGH may be used as a comprehensive and rapid screening test in prenatal unbalanced chromosomal abnormalities detection. We report the results of the first prospective study to evaluate the use of the CGH technique on uncultured amniocytes. Seventy-one amniotic fluid samples, obtained by transabdominal amniocentesis between the 14th and 35th weeks of gestation, were simultaneously investigated using CGH and conventional cytogenetics. Amniocentesis were done for advanced maternal age (21.1%), fetal ultrasound anomalies (73.3%) and high level of biochemical markers in maternal serum (5.6%). Sixty-six (93%) informative results were generated on a total of 71 analysed specimens. Fifty-nine samples were reported as disomic for all autosomes with a normal sex chromosome constitution using CGH and conventional cytogenetics. Among them, three pericentromeric chromosomal inversions were undetected by CGH analysis. Seven numerical aberrations were characterized, including one case of trisomy 13, one case of trisomy 18 and five cases of trisomy 21. Advantages and limitations of CGH for a rapid prenatal screening of unbalanced chromosomal aberrations are discussed.
Naturally Occurring Ingredients as Potential Antiaging Cosmetics (2011)

The criteria adopted for establishing whether a determined substance has potential as a cosmetic constituent are based on the present legislation of each country. In this study, natural antiaging constituents as Fomes officinalis, rice protein and glutamic acid were pharmacologically evaluated using neuromuscular preparation. These constituents induced a neuromuscular blockade, individually and also in mixture, simulating a Botox®, but not, dimethylaminoethanol-effect. The pharmacological knowledge is beneficial since the real effect of each ingredient becomes apparent, increasing the consumer's confidence on the antiaging cosmetic.
Integrity Considerations for Secure Computer Systems (1977)

An integrity policy defines formal access constraints which, if effectively enforced, protect data from improper modification. The author identifies the integrity problems posed by a secure military computer utility. Integrity policies addressing these problems are developed and their effectiveness evaluated. A prototype secure computer utility, Multics, is then used as a testbed for the application of the developed access controls.
Treatment of Refractory Pemphigus Vulgaris With Rituximab (Anti-CD20 Monoclonal Antibody) (2004)

These patients' response suggests that rituximab may be a valuable treatment for refractory PV and warrants further studies to evaluate the risk-benefit ratio in patients with PV showing resistance to classic therapy.
A simple and sensitive method using protein loss measurements to evaluate damage to human hair during combing (1995)

A simple method to quantify hair damage during combing or brushing has been developed. The method involves collecting hair fragments that are chipped from hair during combing and quantitatively measuring the amount of protein using a colorimetric procedure capable of detecting as little as 5 μg of protein per ml. Using this procedure on hair tresses in the laboratory and on live heads (half-head tests), we were able to demonstrate significant differences in protein loss during post-shampoo combing of undamaged and chemically damaged hair previously treated with various shampoos/conditioners. The method is applicable to different types of hair tested, namely, Caucasian, Asian, Oriental and Negroid
Interferon, PKR, Virology, and Genomics: What Is Past and What Is Next in the New Millennium? (2002)

This paper provides an opportunity to reflect on my work in the interferon and cytokine field for the past almost 20 years and to look forward to the future. Winning the Milstein Award in 1999 was a great thrill. I briefly trace the history of my career from New York City to Seattle, leading up to the Paris award, and then look forward to the future that is full of promise because of the near-infinite power of genomics, computers, and other new technologies.
A web service access control model based on role authorization (2007)

Access control is an effective measure to achieve information security and prevent resources from being accessed unauthorized.But current research on access control for web service is mostly based on authorization;thus they do not scale to an enterprise-wide system.In this paper,a role authorization-based web service access control model is constructed,in which users and privileges are not connected directly but put together by roles and then users can obtain corresponding privileges via roles granted on the basis of service feature and accessing state.Thus it can successfully protect the service and prevent unauthorized users from obtaining information.In addition,several key points in implementing the model are also put forward.
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease (2004)

Environmental toxins have been implicated in the etiology of Parkinson's disease. Recent findings of defects in the ubiquitin-proteasome system in hereditary and sporadic forms of the illness suggest that environmental proteasome inhibitors are candidate PD-inducing toxins. Here, we systemically injected six doses of naturally occurring (epoxomicin) or synthetic (Z-lle-Glu(OtBu)-Ala-Leu-al [PSI]) proteasome inhibitors into adult rats over a period of 2 weeks. After a latency of 1 to 2 weeks, animals developed progressive parkinsonism with bradykinesia, rigidity, tremor, and an abnormal posture, which improved with apomorphine treatment. Positron emission tomography demonstrated reduced carbon-11-labeled 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CFT) binding to dopaminergic nerve terminals in the striatum, indicative of degeneration of the nigrostriatal pathway. Postmortem analyses showed striatal dopamine depletion and dopaminergic cell death with apoptosis and inflammation in the substantia nigra pars compacta. In addition, neurodegeneration occurred in the locus coeruleus, dorsal motor nucleus of the vagus, and the nucleus basalis of Meynert. At neurodegenerative sites, intracytoplasmic, eosinophilic, alpha-synuclein/ubiquitin-containing, inclusions resembling Lewy bodies were present in some of the remaining neurons. This animal model induced by proteasome inhibitors closely recapitulates key features of PD and may be valuable in studying etiopathogenic mechanisms and putative neuroprotective therapies for the illness.