gebhart/patrepeval huggingface dataset:
Minimum memory buffers in DSPapplications (1994)

The authors compute the minimum required buffer sizes that still guarantee the construction of a deadlock-free static schedule in synchronous multirate data flow graphs. The results are applicable to the rapid prototyping of DSP algorithms.
Transcutaneous electrical nerve stimulation (TENS) in angina pectoris (1986)

The aim of this study was to determine the efficacy of transcutaneous electrical nerve stimulation (TENS) in the treatment of chronic stable severe angina pectoris. In a short-term study the effect of TENS was studied in 10 male patients with angina pectoris (functional class III and IV). All patients had previously been stabilized on long-term maximal oral treatment. The effects of the treatment were measured by means of repeated bicycle ergometer tests. All patients had an increased working capacity (16-85%), decreased ST segment depression and reduced recovery time during TENS. No adverse effects were observed. A long-term study of TENS on similarly selected patients showed beneficial effects in terms of pain reduction, reduced frequency of anginal attacks, increased physical activity and increased working capacity during bicycle ergometer tests. An invasive study was carried out with respect to systemic and coronary hemodynamics and myocardial metabolism during pacing provoked myocardial ischemia in 13 patients. The results showed that TENS led to an increased tolerance to pacing, improved lactate metabolism, less pronounced ST segment depression. A drop in systolic blood pressure during TENS treatment at identical pacing rates indicated a decreased afterload. An increased coronary flow to ischemic areas in the myocardium was supported by the fact that the rate pressure product during anginal pain increased during TENS.
Reduced coupling loss using a tapered-rib adiabatic-following fiber coupler (1996)

We present the design and experimental demonstration of a tapered-rib adiabatic-following fiber coupler (TRAFFIC). This device is an adaptation of a Shani-Henry mode converter fabricated in (Al)GaAs and designed to increase the coupling efficiency of conventional optical fibers to tightly-confined semiconductor rib waveguide devices. This approach offers the potential of significantly reducing fiber butt coupling losses from the typical values of 7 to 10 dB to values of <1 dB. This long-standing packaging problem is one of the major impediments to the widespread acceptance of semiconductor-based optoelectronics. Moreover, the design can be implemented with minimal increase in fabrication complexity since it uses only a straightforward modification to epitaxial growth, and one additional lithography and etching step.
Transmembrane Protein 18 Enhances the Tropism of Neural Stem Cells for Glioma Cells (2008)

The failure of current glioma therapies is mainly due to the ability of the tumor cells to invade extensively the surrounding healthy brain tissue, hence escaping localized treatments. Neural stem cells (NSC) are able to home in on tumor foci at sites distant from the main tumor mass, possibly enabling treatment of scattered glioma clusters. To make the strategy more effective, we performed a cDNA expression library screening to identify the candidate genes that once overexpressed would enhance the tropism of NSCs for gliomas. Here, we show that a previously unannotated gene, the one encoding transmembrane protein 18 (TMEM18), is one such gene. Overexpression of TMEM18 was seen in the current study to provide NSCs and neural precursors an increased migration capacity toward glioblastoma cells in vitro and in the rat brain. Functional inactivation of the TMEM18 gene resulted in almost complete loss of the migration activity of these cells. Thus, TMEM18 is a novel cell migration modulator. Overexpression of this protein could be favorably used in NSC-based glioma therapy.
Directions in multiprocessor verification (2002)

IBM server products, mainframes and RISC engines, have witnessed an evolution in verification techniques. Costly special-purpose engines and blunt attempts to force operating system initial program load's (IPL's) in simulation have given way to the idea of more complete, lower level simulation with smart testcase generation algorithms. The idea is to explore the state space of the smaller piece of logic more fully before integrating if into its larger residence. This form of divide and conquer is being used in IBM's Austin facility. Shared-Memory Multiprocessor (SMP) verification represents a special case of verification for an entire computer system. Many of its constraints are common with other parts of the system. This paper examines verification from a historical perspective, explores some of the ways of using existing hardware resources without additional capital investment and highlights how IBM's Austin facility addresses SMP simulation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Antimicrobial effects of lysozyme against gram-negative bacteria due to covalent binding of palmitic acid (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntimicrobial effects of lysozyme against gram-negative bacteria due to covalent binding of palmitic acidHisham Radwan Ibrahim, Akio Kato, and Kunihiko KobayashiCite this: J. Agric. Food Chem. 1991, 39, 11, 2077–2082Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/jf00011a039https://doi.org/10.1021/jf00011a039research-articleACS PublicationsRequest reuse permissionsArticle Views1446Altmetric-Citations96LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase‐1 (NIPP‐1) (1999)

Nuclear inhibitor of protein phosphatase-1 (NIPP-1) is one of two major regulatory subunits of protein phosphatase-1 in mammalian nuclei. We report here the cloning and structural characterization of the human NIPP-1 genes, designated PPP1R8P and PPP1R8 in human gene nomenclature. PPP1R8P (1.2 kb) is a processed pseudogene and was localized by in situ hybridization to chromosome 1p33-32. PPP1R8 is an authentic NIPP-1 gene and was localized to chromosome 1p35. PPP1R8 (25.2 kb) is composed of seven exons and encodes four different transcripts, as determined from cDNA library screening, reverse transcriptase-PCR (RT-PCR) and/or EST (expressed sequence tag) database search analysis. NIPP-1alpha mRNA represents the major transcript in human tissues and various cell lines, and encodes a polypeptide of 351 residues that only differs from the previously cloned calf thymus NIPP-1 by a single residue. The other transcripts, termed NIPP-1beta, gamma and delta, are generated by alternative 5'-splice site usage, by exon skipping and/or by alternative polyadenylation. The NIPP-1beta/delta and NIPP-1gamma mRNAs are expected to encode fragments of NIPP-1alpha that differ from the latter by the absence of the first 142 and 224 residues, respectively. NIPP-1gamma corresponds to 'activator of RNA decay-1' (Ard-1) which, unlike NIPP-1alpha, displays in vitro and endoribonuclease activity and lacks an RVXF consensus motif for interaction with protein phosphatase-1. While the NIPP-1alpha/beta/delta-transcripts were found to be present in various human tissues, the NIPP-1gamma transcript could only be detected in human transformed B-lymphocytes.
Photoacoustic tomography: principles and advances. (2016)

Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results.
Immunomodulatory Antibody Therapy of Cancer: The Closer, the Better (2014)

Immune checkpoint blockade therapies have demonstrated promising therapeutic effects; however, clinical outcomes are variable, with only a subgroup of cancer patients achieving durable complete responses. New therapeutic strategies, including local administration of immunomodulatory antibodies, have been considered as better routes for improving the overall efficacy of antibody-based therapy.
Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen (2007)

Signaling through Notch receptors and their transcriptional effector RBP-J is essential for lymphocyte development and function, whereas its role in other immune cell types is unclear. We tested the function of the canonical Notch-RBP-J pathway in dendritic cell (DC) development and maintenance in vivo. Genetic inactivation of RBP-J in the bone marrow did not preclude DC lineage commitment but caused the reduction of splenic DC fraction. The inactivation of RBP-J in DCs using a novel DC-specific deleter strain caused selective loss of the splenic CD8(-) DC subset and reduced the frequency of cytokine-secreting CD8(-) DCs after challenge with Toll-like receptor ligands. In contrast, other splenic DC subsets and DCs in the lymph nodes and tissues were unaffected. The RBP-J-deficient splenic CD8(-) DCs were depleted at the postprogenitor stage, exhibited increased apoptosis, and lost the expression of the Notch target gene Deltex1. In the spleen, CD8(-) DCs were found adjacent to cells expressing the Notch ligand Delta-like 1 in the marginal zone (MZ). Thus, canonical Notch-RBP-J signaling controls the maintenance of CD8(-) DCs in the splenic MZ, revealing an unexpected role of the Notch pathway in the innate immune system.
In Vitro Interaction between Human Immunodeficiency Virus Type 1 Rev Protein and Splicing Factor ASF/SF2-associated Protein, p32 (1996)

Continuous replication of human immunodeficiency virus type 1 requires the expression of the regulatory protein Rev, which binds to the Rev response element (RRE) and up-regulates the cytoplasmic appearance of singly spliced and unspliced mRNA species. It has been demonstrated that the murine protein YL2 interacts with Rev in vivo and modulates the activity of Rev (Luo, Y., Yu, H., and Peterlin, B. M. (1994) J. Virol. 68, 3850-3856). Here we show that the YL2 human homologue, the p32 protein, which co-purifies with alternative splicing factor ASF/SF2, interacts directly with the basic domain of Rev in vitro and that the Rev-p32 complex is resistant to high concentrations of salt or nonionic detergent. Protein footprinting data suggest that Rev interacts specifically with amino acids within the 196-208 region of p32. An analysis of the ternary complex, formed among p32, Rev, and RRE RNA, shows that Rev can bridge the association of p32 and RRE. Furthermore, we demonstrate that exogenously added p32 specifically relieves the inhibition of splicing in vitro exerted by the basic domain of Rev. Our data are consistent with a model in which p32 functions as a link between Rev and the cellular splicing apparatus.
Iron and macronutrients in California coastal upwelling regimes: Implications for diatom blooms (2001)

The supply of iron, relative to that of the macronutrients nitrate, phosphate, and silicic acid, plays a critical role in allowing extensive diatom blooms to develop in coastal upwelling regimes. The presence or absence of a broad continental shelf influences the supply of iron. The iron input to central California upwelling waters varies spatially and can be characterized by two end‐member regimes. One end member, which includes Monterey Bay and extending north to Pt. Reyes, is an iron‐replete regime where upwelling occurs over a relatively broad continental shelf that results in waters with high concentrations of dissolved and particulate iron (&gt;10 nM) entrained together with high concentrations of nitrate and silicic acid. In these iron‐replete regions, extensive blooms of large diatoms deplete macronutrient concentrations, which results in correspondingly high chlorophyll a concentrations. The other end member, located to the south of Monterey Bay off the Big Sur coast, is an iron‐deplete regime where upwelling is focused offshore of a narrow continental shelf. Upwelled waters in the Big Sur region are characterized by low dissolved and particulate iron concentrations (&lt;1 nM), together with high concentrations of nitrate and silicic acid. Extremely low iron concentrations, unused nitrate and silicic acid, and a low abundance of large diatoms characterize surface waters in these iron‐deplete regions, and thus represent coastal upwelling, high‐nutrient, low‐chlorophyll systems limited by the micronutrient iron.
COORDINATION OF MULTIPLE INTELLIGENT SOFTWARE AGENTS (1996)

We are investigating techniques for developing distributed and adaptive collections of information agents that coordinate to retrieve, filter and fuse information relevant to the user, task and situation, as well as anticipate user's information needs. In our system of agents, information gathering is seamlessly integrated with decision support. The task for which particular information is requested of the agents does not remain in the user's head but it is explicitly represented and supported through agent collaboration. In this paper we present the distributed system architecture, agent collaboration interactions, and a reusable set of software components for structuring agents. The system architecture has three types of agents: Interface agents interact with the user receiving user specifications and delivering results. They acquire, model, and utilize user preferences to guide system coordination in support of the user's tasks. Task agents help users perform tasks by formulating problem solving plans and carrying out these plans through querying and exchanging information with other software agents. Information agents provide intelligent access to a heterogeneous collection of information sources. We have implemented this system framework and are developing collaborating agents in diverse complex real world tasks, such as organizational decision making, investment counseling, health care and electronic commerce.
Simian immunodeficiency virus resistance of macaques infused with interferon β-engineered lymphocytes (2000)

To test the in vivo anti-simian immunodeficiency virus (SIV) efficacy of interferon (IFN)-beta-engineered lymphocytes, peripheral blood lymphocytes harvested from two uninfected macaques were transduced with a retroviral vector carrying a constitutively expressed IFN-beta gene and reinfused, resulting in approximately 1 IFN-beta-transduced cell out of 1000 circulating cells. The gene-modified cells were well tolerated and could be detected for at least 74 days without causing any apparent side effects. These two animals together with three untreated control macaques were then infected with SIVmac251. The two IFN-beta-infused macaques are in good health, 478 days after infection, with a reduced plasma virus load and sustained numbers of CD4(+) and CD8(+) cells. Throughout the study, the proportion of IFN-beta-transduced cells has been maintained. Of the three control macaques, two were characterized by a high plasma virus load and a decrease in CD4(+) cells. One was moribund and was sacrificed 350 days after infection and the other now has fewer than 100 circulating CD4(+) cells/ml. Unexpectedly, the third control macaque, which, like the two IFN-beta-infused animals, had a low plasma virus load and a maintenance of CD4(+) and CD8(+) cell number, was characterized by a permanent level of serum IFN-beta, of unknown origin, already present before SIV infection. Although no definite conclusion can be made in view of the limited number of animals, these data indicate that further exploration is warranted of an IFN-beta-based anti-human immunodeficiency virus gene therapy.
MicroRNA in lung cancer (2010)

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction.
Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation (2010)

The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or loss of Phosphatase and Tensin homolog (PTEN). We have uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. Tyr176-phosphorylated AKT localizes to the plasma membrane and promotes Thr308/Ser473-phosphorylation leading to AKT activation. Mice expressing activated Ack1 specifically in the prostate exhibit AKT Tyr176-phosphorylation and develop murine prostatic intraepithelial neoplasia (mPINs). Further, expression levels of Tyr176-phosphorylated-AKT and Tyr284-phosphorylated-Ack1 were positively correlated with the severity of disease progression, and inversely correlated with the survival of breast cancer patients. Thus, RTK/Ack1/AKT pathway provides a novel target for drug discovery.
Coprocessed excipients for solid dosage forms (2004)

Tablet manufacturing has been changed by the introduction of the direct-compression process and high-speed machines.These to developments have increased the demands on the functionality of excipients in terms of flow and compression properties. Particle engineering of individual excipients and excipient combinations using coprocessing, by virtue of subparticle modifications, has provided an attractive tool for developing high-functionality excipients that are suited to modern tablet manufacturing processes.
Rate Distribution Between Model and Signal (2007)

Knowledge of a statistical model of the signal can be used to increase coding efficiency. A common approach is to use a fixed model structure with parameters that adapt to the signal. The model parameters and a signal representation that depends on the model are encoded. We show that, if the signal is divided into segments of a particular duration, and the model structure is fixed, then the optimal bit allocation for the model parameters does not vary with the overall rate. We discuss in detail the parameter rate for the autoregressive (AR) model. Our approach shows that the square error criterion in the signal domain is consistent with the commonly used root mean square log spectral error for the model parameters. Without using perceptual knowledge, we obtain a rate allocation for the model that is consistent with what is commonly used. This model rate is independent of overall coding rate. We provide experimental results for the application of the autoregressive model to speech that confirm the theory.
Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene. (1987)

A transcriptional enhancer has been identified in the first intron of the mouse alpha 2 (type I) collagen gene in a region between +418 and +1524 base pairs from the transcriptional start site. The enhancer functions both when it is located 5' and 3' to the promoter that it activates and is independent of the orientation of the element. The enhancer stimulates both the homologous alpha 2 type I [alpha 2(I)] collagen promoter and the heterologous early simian virus 40 promoter. In transient expression experiments, enhancer-dependent transcription from the alpha 2(I) collagen promoter utilizes the same transcriptional start site as the one used in the endogenous alpha 2(I) collagen gene. The enhancer activates transcription at a distance of at least 3 kilobase pairs from the transcriptional start site. The alpha 2(I) collagen enhancer displays cell specificity, since it is functional in NIH 3T3 fibroblasts but completely inactive in a lymphoid cell line, in contrast to two immunoglobulin gene enhancers that show the opposite behavior. We find several areas of sequence homology with viral enhancers, particularly the enhancer of simian virus 40.
Microalbuminuria in Non—Insulin-Dependent Diabetes Mellitus (1994)

Microvascular and macrovascular disease cause considerable mortality and morbidity both among patients with non-insulin-dependent diabetes mellitus and those with insulin-dependent diabetes mellitus. Furthermore, non-insulin-dependent and insulin-dependent diabetes mellitus overlap in their pathogenesis as well as short- and long-term complications. In the diabetic patient, genetic susceptibility as well as other factors, ie, microalbuminuria, hypertension, high protein intake, blood glucose control, etc, ultimately culminate in a diffuse disease process, eg, diabetic vascular and/or renal disease. Early predictors of susceptibility for development of renal disease in diabetic subjects would help focus our treatment strategies. The role of microalbuminuria as a prognostic marker for the major complications of insulin-dependent diabetes mellitus has been previously reviewed. We reviewed the role of microalbuminuria as prognostic marker for progression of diabetic renal disease in subjects with non-insulin-dependent diabetes mellitus. We examined treatment strategies to lower microalbuminuria and its associated impact on disease progression.