gebhart/patrepeval huggingface dataset:
Compact and fast response ultrasonic detection device based on two-wave mixing in a gallium arsenide photorefractive crystal (2001)

An improved phase demodulator for the detection of ultrasound based on two-wave mixing (TWM) in the diffusion regime in a semi-insulating photorefractive GaAs crystal is presented. A new optical layout is proposed in which the total laser power is injected into the crystal to reduce the grating buildup time. The device is then less sensitive to ambient vibrations or motion of the inspected part. Another new feature of the device is a balanced receiver based on large area InGaAs detectors. The measured rejection ratio of this balanced receiver is 50 dB. However, in this new optical configuration the signal and pump beam paths cannot be made equal which results in some sensitivity to high frequency laser phase noise. The performance of the device operated with a cw and a pulsed laser source is described. A comparison with the conventional confocal Fabry–Perot in the transmission mode is also presented. As expected, the GaAs-based TWM photorefractive system is less sensitive than the Fabry–Perot at high frequencies but becomes more sensitive below some frequency value. For the 30 W pumping level used into the crystal and a 1 m long Fabry–Perot with 85% reflectivity mirrors, this value was found to be about 1.5 MHz. This feature is known to be useful in the cases where low frequencies have to be detected, higher frequencies being attenuated by the material. This is the case of coarse microstructure materials or viscous or mushy materials. This photorefractive configuration is also attractive like all photorefractive systems for compactness and the absence of any need for active stabilization. To obtain a sensitivity equal or better than that of the confocal Fabry–Perot in the transmission mode, this new setup can be used with an InP:Fe or a CdTe:V photorefractive crystal under an applied field.
Hydroxy-Substituted Polyenaminonitrile as a Soluble Precursor for Rigid-Rod Polybenzoxazole (2001)

(1-Chloro-2,2-dicyanovinyl)benzene or 1,4-bis(1-chloro-2,2-dicyanovinyl)benzene was reacted with 2-amino-phenol to give the model compound, hydroxy enaminonitrile, which was found to undergo thermal cyclization reaction to form the corresponding benzoxazole. This intramolecular cyclization reaction is expected to occur through nucleophilic attack to electropositive enamine carbon by ortho-hydroxy group on the phenyl ring, which is accompanied by the release of neutral malononitrile through rearrangement. From each bifunctional monomer, o-hydroxy substituted polyenaminonitrile was prepared and characterized as a new precursor polymer for well-known aromatic polybenzoxazole. Also the unusual macrocyclic dimer formation from the 1,4-bis(1-chloro-2,2-dicyanovinyl)benzene and 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane polymerization reaction system was discussed. The thermal cyclization reactions and the properties of polymers were investigated using FT-IR and thermal analysis (DSC & TGA).
Structural and Functional Analysis of the Recombinant G Domain of the Laminin α4 Chain and Its Proteolytic Processing in Tissues (2000)

The C-terminal G domains of laminin alpha chains have been implicated in various cellular and other interactions. The G domain of the alpha4 chain was now produced in transfected mammalian cells as two tandem arrays of LG modules, alpha4LG1-3 and alpha4LG4-5. The recombinant fragments were shown to fold into globular structures and could be distinguished by specific antibodies. Both fragments were able to bind to heparin, sulfatides, and the microfibrillar fibulin-1 and fibulin-2. They were, however, poor substrates for cell adhesion and had only a low affinity for the alpha-dystroglycan receptor when compared with the G domains of the laminin alpha1 and alpha2 chains. Yet antibodies to alpha4LG1-3 but not to alpha4LG4-5 clearly inhibited alpha(6)beta(1) integrin-mediated cell adhesion to laminin-8, indicating the participation of alpha4LG1-3 in a cell-adhesive structure of higher complexity. Proteolytic processing within a link region between the alpha4LG3 and alpha4LG4 modules was shown to occur during recombinant production and in endothelial and Schwann cell culture. Cleavage could be attributed to three different peptide bonds and is accompanied by the release of the alpha4LG4-5 segment. Immunohistology demonstrated abundant staining of alpha4LG1-3 in vessel walls, adipose, and perineural tissue. No significant staining was found for alpha4LG4-5, indicating their loss from tissues. Immunogold staining demonstrated an association of the alpha4 chain primarily with microfibrillar regions rather than with basement membranes, while laminin alpha2 chains appear primarily associated with various basement membranes.
Reading Bits of Genetic Information: Methods for Single-Nucleotide Polymorphism Analysis (1998)

Reading bits of genetic information: Methods for single-nucleotide poly-mor-phisms analysis.
Synthesis of Model Substances for Polyacrylonitril and Its Co-Polymers (1959)

ポリアクリロニトリルの模型物質として, 炭素原子1個おきにニトリル基のついた鎖状化合物の合成をシアノ酢酸エステルから出発して実施し, 2量体模型としては2.4-ジ-シアノペンタン, 1, 3-ジ-シアノブタン, グルタロニトリル, 3量体模型として2, 4, 6-トリシアノヘプタン, 1, 3, 5-トリシアノヘキサン, 4量体模型として2, 4, 6, 8-テトラシアノノナンを合成した。
Isolation of a Candida albicans gene, tightly linked to URA3, coding for a putative transcription factor that suppresses a Saccharomyces cerevisiae aft1 mutation (2001)

A pathogen such as C. albicans needs an efficient mechanism of iron uptake in an iron-restricted environment such as is the human body. A ferric-reductase activity regulated by iron and copper, and analogous to that in S. cerevisiae, has been described in C. albicans. We have developed an in-plate protocol for the isolation of clones that complement an aft1 mutation in S. cerevisiae that makes cells dependent on iron for growth. After transformation of S. cerevisiae aft1 with a C. albicans library, we have selected clones that grow in conditions of iron deficiency and share an identical plasmid, pIRO1, with a 4500 bp insert containing the URA3 gene and an ORF (IRO1) responsible for the suppression of the iron dependency. IRO1 does not show homology with AFT1 or with other sequences in the databases. Northern analysis demonstrates constitutive expression of IRO1. CAI4, a C. albicans strain isolated as Δura3, also has a deletion of the 3′ half of IRO1, and displays in YNB medium similar phenotypic characteristics to S. cerevisiae aft1 mutant strains. Therefore, we consider IRO1 as a gene of C. albicans involved in the utilization of iron. However, in extreme conditions of iron deprivation, CAI4 seems to activate alternative mechanisms of iron uptake that allow a better growth than the wild strain SC5314. Analysis of its predicted protein sequence is in agreement with a role of Iro1p as a transcription factor. Copyright © 2000 John Wiley & Sons, Ltd.
Potential roles of osteopontin and α V β 3 integrin in the development of coronary artery restenosis after angioplasty (1997)

Angioplasty procedures are increasingly used to reestablish blood flow in blocked atherosclerotic coronary arteries. A serious complication of these procedures is reocclusion (restenosis), which occurs in 30-50% of patients. Migration of coronary artery smooth muscle cells (CASMCs) to the site of injury caused by angioplasty and subsequent proliferation are suggested mechanisms of reocclusion. Using both cultured human CASMCs and coronary atherectomy tissues, we studied the roles of osteopontin (OPN) and one of its receptors, alphavbeta3 integrin, in the pathogenesis of coronary restenosis. We also measured the plasma levels of OPN before and after angioplasty and determined the effect of exogenous OPN on CASMC migration, extracellular matrix invasion, and proliferation. We found that cultured CASMCs during log phase of growth and smooth muscle cell layer of the coronary atherosclerotic tissues of patients express both OPN mRNA and protein at a significantly elevated level compared with controls. Interestingly, whereas the baseline plasma OPN levels in control samples were virtually undetectable, those in patient plasma were remarkably high. We also found that interaction of OPN with alphavbeta3 integrin, expressed on CASMCs, causes migration, extracellular matrix invasion, and proliferation. These effects were abolished when OPN or alphavbeta3 integrin gene expression in CASMCs was inhibited by specific antisense S-oligonucleotide treatment or OPN-alphavbeta3 interaction was blocked by treatment of CASMCs with antibodies against OPN or alphavbeta3 integrin. Our results demonstrate that OPN and alphavbeta3 integrin play critical roles in regulating cellular functions deemed essential for restenosis. In addition, these results raise the possibility that transient inhibition of OPN gene expression or blocking of OPN-alphavbeta3 interaction may provide a therapeutic approach to preventing restenosis.
On the power of straight- line computations in finite fields (1982)

It is shown that a lower hound of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n^{3}</tex> or more on the straight-line complexity of a function <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</tex> over GF <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(2^{n})</tex> is also a lower bound on the network complexity of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">f</tex> and, hence, on the product of run time and program size of Turing machines. It is further shown that most functions over a finite field are hard to compute and that for most hard functions there exists no approximation via an easy algorithm.
Cytokines in the regulation of allograft rejection. (1988)

Stimulation of T lymphocytes with alloantigen leads to release of both IL-2 and IFN-gamma. IL-2 enhances clonal expansion of alloantigen-activated T cells. This permits it to overcome acquired allograft tolerance which, at the efferent limb of the cellular immune response, is caused by reduced clone size of donor-specific cytotoxic lymphocyte precursor cells. Cells exhibiting a low constitutive expression of class I MHC antigenes are refractory to lysis by cytotoxic T cells. This second type of tolerance located at the level of the allogeneic target cells can be easily broken by exogenous IFN-gamma, which increases the density of class I MHC antigens. There is suggestive evidence for enhanced endogenous production of lymphokines during rejection of cardiac allografts in mice and men. Rejection episodes are also associated with increased expression of class I and elevated frequency of class II MHC antigen-positive cells in the cardiac transplants. Whereas early immune recognition of histoincompatible grafts is primarily related to the presence of genetic barriers between donor and recipient, the further amplification of alloreactivity is driven by the release of antigen-unspecific lymphokines. Production of endogenous lymphokines can be modified by a variety of means: methylprednisone, ciclosporin and specific antibodies against lymphokines or their receptors represent effective inhibitors of this amplification mechanism which can finally lead to irreversible graft damage. It is well established in clinical experience that infectious complications subsequent to allografting may precipitate rejection or graft-vs.-host disease. Our finding of increased endogenous IFN-gamma levels during infections, in particular in those caused by cytomegalovirus, provides an explanation for this association.(ABSTRACT TRUNCATED AT 250 WORDS)
Michael Additions Catalysed by N,N-dimethyl-3-aminopropyl - Derivatised Amorphous Silica and Hexagonal Mesoporous Silica (HMS) (1998)

Solid bases prepared by derivatisation of amorphous silica and hexagonal mesoporous silica with dimethylaminopropyl groups are good catalysts for Michael addition reactions. Of the prepared catalysts, those based on hexagonal mesoporous silica show particularly high activities. The sol-gel method used in preparing the catalysts based on hexagonal mesoporous silica enables loading to be increased to more than twice that of those based on amorphous silica which are prepared by the post-modification method.
Psychovisual approach to digital picture watermarking (1998)

The <i>Journal of Electronic Imaging</i> (JEI), copublished bimonthly with the Society for Imaging Science and Technology, publishes peer-reviewed papers that cover research and applications in all areas of electronic imaging science and technology.
Antioxidant Vitamin Intake in Adolescent Israeli Girls (1999)

Antioxidants may reduce risks of cardiovascular and neoplastic diseases based on basic, animal and epidemiological research. Therefore, dietary fat-soluble antioxidant vitamin intake and plasma concentration in healthy adolescent girls was investigated. This age was selected since dietary antioxidant protection against major illnesses is a lifelong requirement and because healthy dietary habits are adopted at an early age and are often modified during adolescence. Seventy-one high school girls, age range 15-18 years, were studied by a semi-quantitative food frequency questionnaire. Plasma antioxidants were measured by high-performance liquid chromatography (HPLC) in 16 girls. The diet provided 30% fat with a caloric intake of 34 kcal kg-1 body weight. Vitamin A intake was 2.2 +/- 1.0 mg/day-1, beta-carotene intake was 6.2 +/- 4.2 mg/day and vitamin E intake was 4.8 +/- 2.1 mg/day-1. Thus, only vitamin E intake was below the recommended allowance for this age range and compared to the USA intake survey at the same age and sex. Plasma antioxidants were all within normal range as compared with other studies. Thus, according to this study, Israeli adolescent girls consume a suboptimal amount of vitamin E in their diet, but sufficient in other fat soluble antioxidants. Though this apparently unbalanced antioxidant intake is not reflected in abnormal plasma concentrations, high intake of vitamin E should be encouraged in order to obtain the maximal benefit from exposure to dietary antioxidants throughout life.
A PILOT DEEP SURVEY FOR X-RAY EMISSION FROM fuvAGB STARS (2015)

We report the results of a pilot survey for X-ray emission from a newly discovered class of AGB stars with far-ultraviolet excesses (fuvAGB stars) using XMM-Newton and Chandra. We detected X-ray emission in 3 of 6 fuvAGB stars observed -- the X-ray fluxes are found to vary in a stochastic or quasi-periodic manner on roughly hour-long times-scales, and simultaneous UV observations using the Optical Monitor on XMM for these sources show similar variations in the UV flux. These data, together with previous studies, show that X-ray emission is found only in fuvAGB stars. From modeling the spectra, we find that the observed X-ray luminosities are ~(0.002-0.2 ) Lsun, and the X-ray emitting plasma temperatures are ~(35-160) x 10^6 K. The high X-ray temperatures argue against the emission arising in stellar coronae, or directly in an accretion shock, unless it occurs on a WD companion. However, none of the detected objects is a known WD-symbiotic star, suggesting that if WD companions are present, they are relatively cool (<20,000 K). In addition, the high X-ray luminosities specifically argue against emission originating in the coronae of main-sequence companions. We discuss several models for the X-ray emission and its variability and find that the most likely scenario for the origin of the X-ray (and FUV) emission involves accretion activity around a companion star, with confinement by strong magnetic fields associated with the companion and/or an accretion disk around it.
The CXCR4 Antagonist AMD3100 Efficiently Inhibits Cell-Surface-Expressed Human Immunodeficiency Virus Type 1 Envelope-Induced Apoptosis (2000)

Infection by human immunodeficiency virus type 1 (HIV-1) has been associated with increased cell death by apoptosis in infected and uninfected cells. The envelope glycoprotein complex ([gp120/gp41](n)) of X4 HIV-1 isolates is involved in both infected and uninfected cell death via its interaction with cellular receptors CD4 and CXCR4. We studied the effect of the blockade of CXCR4 receptors by the agonist stromal derived factor (SDF-1alpha) and the antagonist bicyclam AMD3100 on apoptotic cell death of CD4(+) cells in different models of HIV infection. In HIV-infected CEM or SUP-T1 cultures, AMD3100 showed antiapoptotic activity even when added 24 h after infection. In contrast, other antiviral agents, such as zidovudine, failed to block apoptosis under these conditions. The antiapoptotic activity of AMD3100 was also studied in coculture of peripheral blood mononuclear cells or CD4(+) cell lines with chronically infected H9/IIIB cells. AMD3100 was found to inhibit both syncytium formation and apoptosis induction with 50% inhibitory concentrations ranging from 0.009 to 0.24 microg/ml, depending on the cell type. When compared to SDF-1alpha, AMD3100 showed higher inhibitory potency in all cell lines tested. Our data indicate that the bicyclam AMD3100 not only inhibits HIV replication but also efficiently blocks cell-surface-expressed HIV-1 envelope-induced apoptosis in uninfected cells.
Changes in transcript abundance relating to colony collapse disorder in honey bees ( Apis mellifera ) (2009)

Colony collapse disorder (CCD) is a mysterious disappearance of honey bees that has beset beekeepers in the United States since late 2006. Pathogens and other environmental stresses, including pesticides, have been linked to CCD, but a causal relationship has not yet been demonstrated. Because the gut acts as a primary interface between the honey bee and its environment as a site of entry for pathogens and toxins, we used whole-genome microarrays to compare gene expression between guts of bees from CCD colonies originating on both the east and west coasts of the United States and guts of bees from healthy colonies sampled before the emergence of CCD. Considerable variation in gene expression was associated with the geographical origin of bees, but a consensus list of 65 transcripts was identified as potential markers for CCD status. Overall, elevated expression of pesticide response genes was not observed. Genes involved in immune response showed no clear trend in expression pattern despite the increased prevalence of viruses and other pathogens in CCD colonies. Microarray analysis revealed unusual ribosomal RNA fragments that were conspicuously more abundant in the guts of CCD bees. The presence of these fragments may be a possible consequence of picorna-like viral infection, including deformed wing virus and Israeli acute paralysis virus, and may be related to arrested translation. Ribosomal fragment abundance and presence of multiple viruses may prove to be useful diagnostic markers for colonies afflicted with CCD.
U.S. v. Bailey: An Expansion of Federal Clean Water Act Jurisdiction (2010)

It is easier to seek forgiveness than permission.While
GITR/GITRL: More than an effector T cell co‐stimulatory system (2007)

Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in several cells and tissues including T lymphocytes, NK cells and antigen-presenting cells (APC). GITR activation, upon interaction with its ligand (GITRL), functions as a co-activating signal. GITRL is mainly expressed on APC and GITR/GITRL interaction is important for the development of immune response. This review summarizes recent results about the GITR/GITRL system, focusing on the interplay between APC, effector and regulatory T cells.
Linkage map of Escherichia coli K-12, edition 8 (1990)

The linkage map of Escherichia coli K-12 depicts the arrangement of genes on the circular chromosome of this organism. The basic units of the map are minutes, determined by the time-of-entry of markers from Hfr into F- strains in interrupted-conjugation experiments. The time-of-entry distances have been refined over the years by determination of the frequency of cotransduction of loci in transduction experiments utilizing bacteriophage P1, which transduces segments of DNA approximately 2 min in length. In recent years, the relative positions of many genes have been determined even more precisely by physical techniques, including the mapping of restriction fragments and the sequencing of many small regions of the chromosome. On the whole, the agreement between results obtained by genetic and physical methods has been remarkably good considering the different levels of accuracy to be expected of the methods used. There are now few regions of the map whose length is still in some doubt. In some regions, genetic experiments utilizing different mutant strains give different map distances. In other regions, the genetic markers available have not been close enough to give accurate cotransduction data. The chromosome is now known to contain several inserted elements apparently derived from lambdoid phages and other sources. The nature of the region in which the termination of replication of the chromosome occurs is now known to be much more complex than the picture given in the previous map. The present map is based upon the published literature through June of 1988. There are now 1,403 loci placed on the linkage group, which may represent between one-third and one-half of the genes in this organism.
Learning Sparse Features in Granular Space for Multi-View Face Detection. (2006)

In this paper, a novel sparse feature set is introduced into the Adaboost learning framework for multi-view face detection (MVFD), and a learning algorithm based on heuristic search is developed to select sparse features in granular space. Compared with Haar-like features, sparse features are more generic and powerful to characterize multi-view face pattern that is more diverse and asymmetric than frontal face pattern. In order to cut down search space to a manageable size, we propose a multi-scaled search algorithm that is about 6 times faster than brute-force search. With this method, a MVFD system is implemented that covers face pose changes over +/-45 ° rotation in plane (RIP) and +/-90 ° rotation off plane (ROP). Experiments over well-know test set are reported to show its high performance in both accuracy and speed. 1.
π-Conjugated Aromatic Enynes as a Single-Emitting Component for White Electroluminescence (2006)

By use of the organolanthanide catalysts Me2Si(C5Me4)(NAr)Lu(CH2SiMe3)(THF) and (C5Me5)2LaCH(SiMe3)2, carbazole-substituted phenyl enynes (Z)-CPEY and (E)-CPEY were synthesized, respectively, with excellent regio- and stereoselectivity through the catalytic dimerization of the corresponding terminal alkyne. These new pi-conjugated compounds, in particular, the (E)-enyne isomer (E)-CPEY, act as an excellent single-emitting component for white organic light-emitting devices (WOLEDs), as a result of combination of the blue emission from an isolated molecule with the longer-wavelength emissions (green and orange-red) from excimers. The (E)-CPEY-based double-layer device emitted almost pure white light with CIE coordinates of (0.32, 0.33), maximum brightness of 1395 cd m-2, and maximum current efficiency of 2.07 cd A-1. This is perhaps the purest white emission ever reported for a single-emitting-component WOLED. The quality of the white emission remained almost unchanged under varying driving voltages, demonstrating an advantageous potential of single-emitting-component WOLEDs.