gebhart/patrepeval huggingface dataset:
Linear precoders and decoders designs for MIMO frequency selective channels (2002)

In this paper we derive and compare designs for the optimal linear precoderes to be used in transmissions over frequency selective multiple-input multiple-output (MIMO) channels. We assume as alternative design constraints the average transmit power and the peak power. The design criteria are scalable with respect to the number of antennas, size of the coding block and transmit average/peak power. The solutions are shown to convert in both cases the MIMO channel with memory into a set of parallel independent fiat fading subchannels, regardless of the design criterion, while appropriate power/bits loading on the sub-channels is the specific signature of the different designs.
Complicated Pain Management in a CYP450 2D6 Poor Metabolizer (2007)

We describe the case of a patient with significant adverse effects from posttraumatic analgesic therapy with opioid analgesics who was found by microarray analysis to have a CYP2D6 genotype predictive of a poor metabolizer phenotype. In addition to her poor tolerance and limited response to opioid analgesics, she developed further discomfort when the antiemetic promethazine was administered to treat her gastrointestinal adverse effects. In our discussion we review the literature about the clinical impact of CYP450 2D6 polymorphisms in treatment with the commonly used opioid analgesics codeine, oxycodone, hydrocodone, hydromorphone, and morphine, as well as the antiemetic promethazine. The case we present, as well as the literature we review, demonstrates the clinical utility of CYP2D6 genotyping in patients with adverse effects from analgesia therapy.
Ex vivo expansion of cord blood-derived stem cells and progenitors. (1994)

Cord blood-derived CD34+ cells have proved superior to adult marrow or elicited peripheral blood in ex vivo cell and progenitor expansion. In addition, cord blood-derived cells with a phenotype and function of early stem cells (e.g., long-term culture-initiating cells) can be expanded in vitro in the presence of a combination of cytokines by 15- to 20-fold over 7-14 days. These observations suggest that ex vivo expansion of cord blood CD34+ cells will permit improved engraftment of adults and will prove effective in retroviral-mediated gene transfection of early stem cell populations.
Vailidation of immunoassays for anti-drug antibodies. (2003)

Several methods for the detection of an antibody response to a protein therapeutic are described along with their limitations. Emphasis is placed on immunoassays with specific attention to the ELISA format. Potential sources of interference and issues to consider in the design of an anti-drug antibody assay are reviewed. Establishment of criteria for validation of an anti-drug assay are discussed including inter-assay and intra-assay precision for the positive and negative controls, limit of detection, incidence of false positives, reactivity in unexposed populations, linearity of dilution, and interference issues. Finally, a case study involving the development of an anti-host cell protein contaminant assay involving responses to Chinese hamster ovary (CHO) cell contaminants is reviewed. Detection of an immune response to a biotherapeutic is critical to an understanding of its' safety and efficacy. Outlined in this paper are standard parameters for validation of an immunoassay as well as practical considerations for the development and validation of an anti-protein antibody assay.
Constructive page description (1991)

An open approach to graphic arts and prepress information exchange called constructive page description (CPD) is described. An existing approach for the exchange of continuous tone picture and line art data between electronic prepress systems called the Digital Data Exchange Specification (DDES) is examined, and its deficiencies are revealed. The goals of the CPD approach and its basic concepts are outlined. Viewing CPDs as directed graphs is discussed and data types and operations, data organization, and the evaluation mechanism are considered. The application of CPD is discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. (1996)

Cyclin-dependent kinase 5(cdk5) is highly homologous to other members of the cdk family that are known to function in proliferating cells. Despite the structural similarity, cdk5-associated histone H1 kinase activity is only detectable in postmitotic neurons of the central nervous system (CNS). p35 is a neuronal-specific cdk5 regulator that activates cdk5 kinase activity upon association. The cdk5/p35 kinase activity increases during the progression of CNS neurogenesis, suggesting a function of cdk5 in neuronal differentiation. Here we show that both cdk5 and p35 proteins are present in the growth cones of developing neurons. The staining pattern of cdk5 in the growth cones is similar to that of actin filaments but not microtubules. To address the functional significance of the cdk5/p35 kinase in neurogenesis, we ectopically expressed wild-type or mutant kinases in cortical cultures. Expression of dominant-negative mutants of cdk5 (cdk5N144 and cdk5T33) inhibited neurite outgrowth, which was rescued by coexpression of the wild-type proteins. A similar extent of neurite outgrowth inhibition was obtained by transfection of an antisense p35 construct, which in turn was only rescued by p35 but not cdk5 coexpression. In contrast, longer neurites were elaborated in neurons that coexpressed exogenous cdk5 and p35. These observations suggest that the cdk5/p35 kinase plays a critical role in neurite outgrowth during neuronal differentiation.
Strategies and Methods in the Identification of Antagonists of Protein-Protein Interactions (2003)

The identification of antagonists of protein-protein interactions is a critical challenge to the pharmaceutical industry. The selection of a protein target, which is amenable to antagonism, is the first of many decisions that determine the success of these efforts. In addition, the definition of strategies and the development and application of methodologies appropriate to that target will be vital to the success of efforts to identify antagonists of a protein-protein interaction. An analysis of current approaches to the identification of lead molecules demonstrates that a search for competitors of a known binder is the basis of traditional screening as well as more modern approaches based on structure activity relationship (SAR) by nuclear magnetic resonance (NMR), molecular fragments, rational design, and tethering. The latter methods employ a structural perspective, throughout the discovery and optimization of a lead, to provide the practitioner with some control over the success of the process.
Effect of up-front daclizumab when combined with steroids for the treatment of acute graft-versus-host disease: results of a randomized trial (2004)

The standard initial therapy for acute graft-versus-host disease (GVHD) is corticosteroids. Daclizumab is a humanized monoclonal antibody against the interleukin 2 (IL-2) receptor expressed on activated T lymphocytes. Because of daclizumab's favorable toxicity profile and response rate in steroid-resistant GVHD, a multicenter, double-blinded, randomized study of corticosteroids with or without daclizumab for initial treatment of acute GVHD was conducted. A total of 102 evaluable subjects of the targeted 166 were enrolled at 5 participating sites. Methylprednisolone at a dose of 2 mg/kg or daily equivalent was given in conjunction with daclizumab 1 mg/kg or placebo on study days 1, 4, 8, and weekly as long as clinically indicated. The groups were balanced for clinical characteristics. GVHD response rates by study day 42 were similar (53% vs 51%; P =.85). The study was halted after a planned interim analysis showed a significantly worse 100-day survival in the group receiving corticosteroids plus daclizumab (77% vs 94%; P =.02). Overall survival at 1 year was also inferior in the combination arm (29% vs 60%; P =.002). Both relapse- and GVHD-related mortality contributed to the increased mortality in the combination group. The combination of corticosteroids and daclizumab should not be used as initial therapy of acute GVHD.
Fusion of Color Photometric Stereo Method and Slit Pattern Projection Method to Measure Three-Dimensional Shapes of a Human Face (2003)

We propose a new method for measuring three-dimensional (3D) moving facial shapes. This method uses photometric stereo method and slit pattern projection method with color light sources. The time required for sampling data can be reduced by switching the color light rays at high speed, and hence a series of 3D shapes of a moving human face at each instant can be measured. Experimental results are shown to demonstrate the feasibility of the proposed method.
Chloride and potassium removal efficiency of an ash leaching system (2008)

Copyright Pulp &amp; Paper Canada. Reprinted with permission from Annex Business Media.
Image Registration Techniques: An overview (2009)

Image registration is a vital problem in medical imaging. It has many potential applications in clinical diagnosis (Diagnosis of cardiac, retinal, pelvic, renal, abdomen, liver, tissue etc disorders). It is a process of aligning two images into a common coordinate system thus aligning them in order to monitor subtle changes between the two. Registration algorithms compute transformations to set correspondence between the two images the purpose of this paper is to provide a comprehensive review of the existing literature available on Image registration methods. We believe that it will be a useful document for researchers longing to implement alternative Image registration methods for specific applications.
Acute Interactions of Buprenorphine with Intravenous Cocaine and Morphine (1993)

Recent preclinical and clinical studies suggest that buprenorphine, an opioid mixed agonist-antagonist, may be useful for the treatment of dual dependence on cocaine and opiates. This report describes an inpatient clinical evaluation of the safety of buprenorphine alone and in combination with single doses of cocaine and morphine. Twenty subjects with a DSM-III-R diagnosis of concurrent cocaine and opioid dependence were randomly assigned to maintenance treatment with single daily doses of 4 or 8 mg of sublingual buprenorphine for 21 days. Side effects and vital signs were evaluated every day once every 8 hours and for 2 hours after daily buprenorphine administration. The physiologic effects of a single-blind challenge dose of cocaine (30 mg intravenously), morphine (10 mg intravenously), and intravenous saline placebo were measured before and during buprenorphine maintenance. Before buprenorphine maintenance, subjects underwent methadone detoxification followed by a 9-day drug-free period. Three baseline single-blind challenge dose studies were conducted on study days 7, 8, and 9 during the drug-free period. Cardiovascular responses to cocaine and to morphine were equivalent under drug-free and buprenorphine maintenance conditions. Respiration and temperature changes in response to cocaine were also equivalent before and during buprenorphine maintenance. Respiratory rates were slightly lower after morphine administration during maintenance on 8 mg of buprenorphine, but this was not statistically significant. Mild opioid agonist-like side effects were reported during buprenorphine induction and maintenance. These included headache, sedation, nasal discharge, abdominal discomfort, and anxiety. Most opioid agonist side effects decreased within 12 to 14 days. An electrocardiogram and blood chemistry measures were normal before and during buprenorphine maintenance. These data suggest that daily maintenance on buprenorphine is not associated with adverse side effects or toxic interactions with a single acute dose of intravenous cocaine or morphine.
Chemokines: signal lamps for trafficking of T and B cells for development and effector function (1999)

Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKbeta-11/MIP-3beta/ELC, SLC/6Ckine/Exodus2, MIP-1beta, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKbeta-11/MIP-3beta/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue-specific infiltration of effector lymphocytes.
Genetic Regulation: The Lac Control Region (1975)

The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.
Residues Phe342–Asn346 of Activated Coagulation Factor IX Contribute to the Interaction with Low Density Lipoprotein Receptor-related Protein (2003)

When blood coagulation factor IX is converted to activated factor IX (factor IXa), it develops enzymatic activity and exposes the binding sites for both activated factor VIII and the endocytic receptor low density lipoprotein receptor-related protein (LRP). In the present study we investigated the interaction between factor IXa and LRP in more detail, using an affinity-purified soluble form of LRP (sLRP). Purified sLRP and full-length LRP displayed similar binding to factor IXa. An anti-factor IX monoclonal antibody CLB-FIX 13 inhibited factor IXa.sLRP complex formation. Both the antibody and a soluble recombinant fragment of LRP (i.e. cluster IV) interfered with factor IXa amidolytic activity, suggesting that the antibody and LRP share similar binding regions near the active site of factor IXa. Next, a panel of recombinant factor IXa variants with amino acid replacements in the surface loops bordering the active site was tested for binding to antibody CLB-FIX 13 and sLRP in a solid phase binding assay. Factor IXa variants with mutations in the region Phe(342)-Asn(346), located between the active site of factor IXa and factor VIII binding helix, showed reduced binding to both antibody CLB-FIX 13 and sLRP. Surface plasmon resonance analysis revealed that the variant with Asn(346) replaced by Asp displayed slower association to sLRP, whereas the variant with residues Phe(342)-Tyr(345) replaced by the corresponding residues of thrombin showed faster dissociation. Recombinant soluble LRP fragment cluster IV inhibited factor IXa-mediated activation of factor X with IC(50) values of 5 and 40 nm in the presence and absence of factor VIII, respectively. This inhibition thus seems to occur via two mechanisms: by interference with factor IXa.factor VIIIa complex assembly and by direct inhibition of factor IXa enzymatic activity. Accordingly, we propose that LRP may function as a regulator of blood coagulation.
p -type SiGe channel modulation doped field-effect transistors with post-evaporation patterned submicrometre Schottky gates (1993)

Schottky gate biased p-type MODFETs with an Si0.03Ge0.35 channel are presented. A wet-chemical post-evaporation procedure of the Schottky gates allows the reduction of the gate length LG to submicrometre dimensions (0.5 μm). The gate length dependence of the transconductance gme and gmi is reported. Maximum values are 37 or 103mS/mm at 300 or 77 K. The devices work in the enhancement mode.
Recovery of Small DNA Fragments from Serum Using Compaction Precipitation (2012)

Background: While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal diagnosis, early cancer detection, and the diagnosis of infectious diseases. However, DNA circulating in blood is usually present at very low concentrations (ng/ml), and is in the form of relatively small fragments (,1,000 bp), making its isolation challenging.
Programmable stream processors (2003)

The demand for flexibility in media processing motivates the use of programmable processors. Stream processing bridges the gap between inflexible special-purpose solutions and current programmable architectures that cannot meet the computational demands of media-processing applications. The central idea behind stream processing is to organize an application into streams and kernels to expose the inherent locality and concurrency in media-processing applications. The performance of the Imagine stream processor on these media application is given.
Optical and Electrochemical Properties of cis-1,2-Dicyano-1,2-bis(2,4,5-trimethyl-3-thienyl)ethene (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptical and Electrochemical Properties of cis-1,2-Dicyano-1,2-bis(2,4,5-trimethyl-3-thienyl)etheneTakashi Koshido, Tsuyoshi Kawai, and Katsumi YoshinoCite this: J. Phys. Chem. 1995, 99, 16, 6110–6114Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/j100016a055https://doi.org/10.1021/j100016a055research-articleACS PublicationsRequest reuse permissionsArticle Views471Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
THE INTERACTION BETWEEN TOXOPLASMA GONDII AND MAMMALIAN CELLS (1972)

Electron microscope methods have been used to study delivery of macrophage primary or secondary lysosomal contents to phagocytic vacuoles containing living or dead toxoplasmas. Secondary lysosomes were labeled by culturing the cells in colloidal thorium dioxide (thorotrast) or in ferritin. Acid phosphatase cytochemistry was employed for detection of primary as well as secondary lysosomal constituents. These various lysosomal labels were present in nearly all vacuoles containing toxoplasmas killed with glutaraldehyde, or in vacuoles containing those parasites undergoing degeneration 1 hr after the uptake of living toxoplasmas. In contrast, at times ranging from 1 to 20 hr after infection, no vacuoles containing morphologically normal, apparently viable toxoplasmas were thorotrast or ferritin positive, and only rarely did these vacuoles react for acid phosphatase. In many instances vacuoles containing viable toxoplasmas and no lysosomal markers were situated in the same cell nearby to vacuoles containing degenerating toxoplasmas and lysosomal constituents, thus indicating that the determinants of lysosomal fusion were operating locally in the immediate vicinity of the phagocytic vacuole, and not operating to influence general cell function. Thus, some toxoplasmas are able to prevent the delivery of lysosomal contents, and apparently the phagocytic vacuole provides for these parasites a sheltered microenvironment ideal for their growth. Morphologic evidence indicated that living toxoplasmas altered the phagocytic vacuolar membrane in macrophages, fibroblasts, and HeLa cells. Within minutes after phagocytosis, the vacuole became surrounded by closely apposed strips of endoplasmic reticulum and mitochondria; somewhat later, microvillous protrusions of the membrane into the vacuole were seen. These morphologic features of phagocytic vacuoles containing living toxoplasmas may be of importance in relation to the absence of lysosomal fusion, or they may serve some function in protecting the host cell or in nourishing the parasite.
A gradient inverse planning algorithm with dose‐volume constraints (1998)

An inverse planning algorithm for determining the intensity-modulated beams that will most closely generate a desired dose distribution is presented. The algorithm is three-dimensional and does not explicitly depend on beam energies and modalities. It allows a single prescription dose or a window of acceptable doses to be specified for the target, with additional constraints to account for under- or over-dosing. For the protection of organs at risk, it provides maximum-dose and dose-volume constraints. The latter apply to the entire volume of the organ exposed to the corresponding dose levels. Several levels of each type of constraint, with varying penalty weights, may be specified for each organ. The objective function that serves as the measure of the goodness of the solution is of the least-squares type and is minimized using conjugate gradient methods. Typical clinical cases involving 40,000 points and 4000 rays to be determined require about 10 min of CPU time on a DEC AlphaStation. Results are presented for two clinical sites, prostate and lung. The optimization algorithm yielded plans that featured higher target dose homogeneity, compared with the human planner's plan, while selectively sparing more of the normal organs at the desired dose regions.
Evidência de validade de critério para o Teste de Criação de Metáforas (2007)

The aim of this study was to investigate the criterion validity for the Metaphor Creation Test. According to the literature, the creation of metaphors is a variable associated with creativity. The initial hypothesis was that professionals who work as advertisers with the creation of advertisement would present ideas with more metaphoricity, and consequently with more creativity. The criterion group was composed by eigth advertisers, 75% male, with average age of 28. A second group was formed by 45 professionals of several areas, 67% male, with average age of 34 years. Both groups answered the Metaphor Creation Test individually. The results indicated that the criterion group presented ideas with better quality and a higher quantity of metaphors, which means they presented ideas with more metaphoricity, indicating a higher level of creativity. Therefore, a criterion validity for the Metaphor Creation Test was found.