gebhart/patrepeval huggingface dataset:
Le radon traceur du transport des fluides dans le sol : simulation modelisation et applications geophysiques (1992)

Uneasiness in the media observed in time of world crisis has been illustrated by the communicative manipulation developed during the first Gulf War. We are bringing a matter for serious thought regarding a possible increase of this uneasiness with the outbreak of new religious stakes - and even new esoteric stakes. Recalling elements of History of Sciences, we are pointing to « the magical origins of technosciences », especially the links which have existed between occult sciences, hermeticism and experimental sciences at the birth of modern science. We are questioning the possibilities of mass manipulation allowed by projects combining various technological means (network of satellites equipped with lasers, electromagnetic plants, etc.) which enable to stage a real « world virtual reality show » likely to deceive large populations. Whereas esoteric popularization is increasing, we are underlining the importance of the spreading of esoteric themes in the culture particularly through television series and movies. Esoteric and religious discourses burst in the media with an increased frequency and intensity. We are raising the question of relations between the magic and religious world and the technological and scientific world : irrational beliefs and practices seem to surround technosciences, including the communication field.
Multiplexed holographic polymer dispersed liquid crystals (2001)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. K. Fontecchio, C. C. Bowley, S. M. Chmura, Li Le, S. Faris, and G. P. Crawford, "Multiplexed holographic polymer dispersed liquid crystals," J. Opt. Technol. 68, 652- (2001) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Isolation of a complementary DNA encoding a chitinase with structural homology to a bifunctional lysozyme/chitinase. (1989)

An extracellular, acidic chitinase was purified to homogeneity from tobacco necrosis virus-infected leaves of Cucumis sativis. The amino acid sequences of the intact protein and of peptides isolated following endoproteinase Lys-C digestion, cyanogen bromide cleavage, and trypsin digestion were determined. Oligonucleotide probes derived from this sequence were used to isolate a cDNA clone encoding this protein. No significant homology was found between this chitinase and either the basic chitinase isolated from bean or tobacco or the chitinase isolated from Serratia marcescens; however, strong homology was found between the cucumber chitinase and a lysozyme/chitinase from Parthenocissus quinquifolia. The induction of the protein by tobacco necrosis virus infection or salicylate was found to be at the level of RNA accumulation. Genomic Southern analysis indicates that a single gene in the cucumber genome encodes this protein.
A MADS domain gene involved in the transition to flowering in Arabidopsis (2000)

Flowering time in many plants is triggered by environmental factors that lead to uniform flowering in plant populations, ensuring higher reproductive success. So far, several genes have been identified that are involved in flowering time control. AGL20 (AGAMOUS LIKE 20) is a MADS domain gene from Arabidopsis that is activated in shoot apical meristems during the transition to flowering. By transposon tagging we have identified late flowering agl20 mutants, showing that AGL20 is involved in flowering time control. In previously described late flowering mutants of the long-day and constitutive pathways of floral induction the expression of AGL20 is down-regulated, demonstrating that AGL20 acts downstream to the mutated genes. Moreover, we can show that AGL20 is also regulated by the gibberellin (GA) pathway, indicating that AGL20 integrates signals of different pathways of floral induction and might be a central component for the induction of flowering. In addition, the constitutive expression of AGL20 in Arabidopsis is sufficient for photoperiod independent flowering and the over-expression of the orthologous gene from mustard, MADSA, in the classical short-day tobacco Maryland Mammoth bypasses the strict photoperiodic control of flowering.
Multi-Tumor-Antigen-Specific Cytotoxic T Lymphocytes For Therapy Of Hematologic Malignancies (2010)

Tumor immunotherapy using in vitro expanded cytotoxic T lymphocytes (CTLs) can effectively treat virus-associated malignancies such as EBV +ve Hodgkin's Lymphoma. However, extension to non virus-associated malignancies has been complicated by the low frequency of circulating T-cells reactive against tumor-expressed antigens, which are often anergized or tolerized. To overcome T-cell anergy we activated T cells in the presence of a potent cytokine cocktail including IL12 (Th1 polarizing), IL7 and IL15 (pro-survival/-proliferative), and IL-6 (Treg inhibitory). We optimized the generation of polyclonal, multiTA-reactive CTLs by combining these cytokines with autologous dendritic cells nucleofected with combinations of DNA tumor antigen (TA)-encoding plasmids or pulsed with multiple TA pepmixes as APCs. The use of whole antigen increases the range of suitable patient HLA polymorphisms beyond those matched to single peptides, while targeting multiple antigens simultaneously reduces the risk of tumor immune evasion. Antigen combinations were chosen based on their tumor expression profile. To target lymphoma we grouped SSX2, Survivin, and MAGEA4 and were consistently able to generate multiTAA CTL directed against these three antigens (n=6 healthy donors). The lines were polyclonal comprising CD4+ (mean 57+/-7%) and CD8+ (mean 40+/-16%) T cells, with reactivity against SSX2, Survivin and MAGEA4 (median 345, 290 and 255 spot forming units (SFU)/1×106 CTL respectively in IFNg ELIspot, n=6). The CTLs were cytolytic against autologous SSX2 and Survivin pepmix-pulsed targets (mean 53% and 30% specific lysis, E:T 40:1) and against whole Survivin antigen-expressing fibroblasts (30% specific lysis, E:T 100:1) with no recognition of non-transduced control targets (9%) in a standard Cr51 release assay. For leukemia we targeted WT1, Prame, PR3, and Survivin and generated CTL lines with reactivity against WT1 (mean 733 SFU), PRAME (mean 555 SFU), PR3 (mean 145 SFU), and Survivin (mean 32 SFU/1×106 CTL), n=2. Hence it is feasible to generate single tumor specific CTL lines that target multiple tumor antigens simultaneously thereby reducing the risk of tumor escape and simplifying clinical application.
Digital Plasmonic Absorption Modulator Exploiting Epsilon-Near-Zero in Transparent Conducting Oxides (2016)

Optical switches operated around <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\varepsilon$</tex-math></inline-formula> -near-zero (ENZ) of transparent conducting oxides (TCOs) are analyzed. A digital optical switching behavior is derived that is quite different from earlier predictions. The digital modulation characteristic originates from the fact that the nonlinear switching is, to a large extent, performed in the ENZ layer. The ENZ layer, however, arises from carrier accumulation in the TCO and is confined to a relatively thin layer with a characteristic dimension that does not change upon applying a higher voltage. An accurate treatment of this inhomogeneous layer is vital to reliably predict modulation characteristics. Such nonlinear accumulation processes and inhomogeneous material properties require refined simulations, which is why we apply an iterative solver based on a high-order finite-element method. More precisely, we solve the nonlinear stationary quantum hydrodynamic model to derive the carrier concentration upon applying an electrical field across the modulator. The result is then directly coupled to Maxwell's equation, which shows a strong local enhancement of the electromagnetic fields in the ENZ layer. In an exemplary implementation, we forecast the feasibility of 6 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu\textrm{m} $</tex-math></inline-formula> long TCO absorption modulators with on-state losses of 2.8 dB and extinction ratios above 10 dB.
Generation of enhancer trap lines in Arabidopsis and characterization of expression patterns in the inflorescence (1999)

Eleven thousand, three hundred and seventy enhancer/promoter trap lines in Arabidopsis were generated via T-DNA transformation utilizing the binary vector pD991 that contains a minimal promoter fused to the uidA reporter gene. Overall 31% of the lines generated exhibit a staining pattern in the inflorescence. Flanking DNA has been cloned from 15 lines exhibiting inflorescence staining patterns by either thermal asymmetric interlaced PCR (TAIL-PCR), inverse PCR (IPCR), or partial library construction. Seeds from these lines are available from the ABRC and NASC Arabidopsis stock centers and DNA pools are available from the ABRC.
Specificity tuning of antibody fragments to neutralize two human chemokines with a single agent (2009)

Chemokines are important mediators of the immune response that are responsible for the trafficking of immune cells between lymphoid organs and migration towards sites of inflammation.Using phage display selection and a functional screening approach, we have isolated a panel of single-chain fragment variable (scFv) capable of neutralizing the activity of the human chemokine CXCL10 (hCXCL10). One of the isolated scFv was weakly cross-reactive against another human chemokine CXCL9,but was unable to block its biological activity. We diversified the complementarity determining region 3 (CDR3) of the light chain variable domain (VL) of this scFv and combined phage display with high throughput antibody array screening to identify variants capable of neutralizing both chemokines. Using this approach it is therefore possible to engineer pan-specific antibodies that could prove very useful to antagonize redundant signaling pathways such as the chemokine signaling network.
Enantioselective Epoxidation of Chromene Derivatives Using Hydrogen Peroxide as a Terminal Oxidant (1994)

Hydrogen peroxide was found to serve as an effective terminal oxidant for the salen-catalyzed asymmetric epoxidation of chromene derivatives, when N-methylimidazole was added to the reaction medium. Under the conditions, 6-acetamido-2,2-dimethyl-7-nitrochromene was converted into the corresponding epoxide of 95% ee in 98% yield.
Determinants of tumor blood flow: a review. (1988)

Blood flow rate in a vascular network is proportional to the pressure difference between the arterial and venous sides and inversely proportional to the viscous and geometric resistances. Despite rapid progress in recent years, there is a paucity of quantitative data on these three determinants of blood flow in tumors and several questions remain unanswered. This paper reviews our current knowledge of these three parameters for normal and neoplastic tissues, the methods of their measurements, and the implications of the results in the growth and metastasis formation as well as in the detection and treatment of tumors. Microvascular pressures in the arterial side are nearly equal in tumor and nontumorous vessels. Pressures in venular vessels, which are numerically dominant in tumors, are significantly lower in a tumor than those in a nontumorous tissue. Decreased intravascular pressure and increased interstitial pressure in tumors are partly responsible for the vessel collapse as well as the flow stasis and reversal in tumors. The apparent viscosity (viscous resistance) of blood is governed by the viscosity of plasma and the number, size, and rigidity of blood cells. Plasma viscosity can be increased by adding certain solutes. The concentration of cells can be increased by adding cells to blood or by reducing plasma volume. The rigidity of RBC, which are numerically dominant in blood, can be increased by lowering pH, elevating temperature, increasing extracellular glucose concentration, or making the suspending medium hypo- or hypertonic. Effective size of blood cells can be increased by forming RBC aggregates (also referred to as rouleaux). RBC aggregation can be facilitated by lowering the shear rate (i.e., decreasing velocity gradients) or by adding macromolecules (e.g., fibrinogen, globulins, dextrans). Since cancer cells and WBC are significantly more rigid than RBC, their presence in a vessel may also increase blood viscosity and may even cause transient stasis. Finally, due to the relatively large diameters of tumor microvessels the Fahraeus effect (i.e., reduction in hematocrit in small vessels) and the Fahraeus-Lindqvist effect (i.e., reduction in blood viscosity in small vessels) may be less pronounced in tumors than in normal tissues. Geometric resistance for a network of vessels is a complex function of the vascular morphology, i.e., the number of vessels of various types, their branching pattern, and their length and diameter. Geometric resistance to flow in a single vessel is proportional to the vessel length and inversely proportional to vessel diameter to the fourth power.(ABSTRACT TRUNCATED AT 400 WORDS)
Increased Aggressiveness of Thyroid Cancer in Patients with Graves' Disease* (1990)

To evaluate whether coexistence of Graves' disease affects the prognosis of thyroid cancer we examined the clinical and pathological characteristics of 22 differentiated thyroid carcinomas concomitant with hyperthyroidism; 13 were associated with Graves' disease, and 9 with autonomous thyroid nodules. Carcinomas were identified in a consecutive series of 359 hyperthyroid patients (132 with Graves' disease and 227 with autonomous thyroid nodules) who underwent surgery during a 6-yr period. One hundred and thirty-seven thyroid carcinomas were found in the 582 euthyroid patients operated on in the same period. In Graves' patients, carcinomas were more often multifocal (46.1% vs. 0%), locally invasive (61.5% vs. 11.1%), and metastatic to lymph nodes (61.5% vs. 11.1%) or to distant sites (23.0% vs. 0%) than in patients with autonomous thyroid nodules. In addition, carcinomas concomitant with Graves' disease were larger (3.3 +/- 1.8 vs. 1.0 +/- 0.7 cm) than the ones associated with autonomous thyroid nodules and showed a high recurrence rate. In euthyroid patients, aggressiveness of thyroid cancer was intermediate. Serum TSH levels were suppressed in all hyperthyroid patients with thyroid cancer. However, circulating thyroid-stimulating antibodies were present in 12 of 13 cancer patients with Graves' disease, but were absent in patients with autonomous thyroid nodules. Our study suggests, therefore, that TSAb may play a role in determining the high aggressiveness of thyroid cancer in Graves' disease patients and indicates that a vigorous treatment should be pursued in this subgroup of patients.
Tumor necrosis factor receptor type‐1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat (2003)

Carrageenan-induced inflammatory pain lasting hours to days produces a protein kinase C epsilon (PKC epsilon )-dependent 'primed' state lasting several weeks, during which time injection of prostaglandin E2 induces hyperalgesia which is markedly enhanced and prolonged compared to PGE2-induced hyperalgesia in normal 'unprimed' rats. In the present study, we demonstrate that while inhibition of prostaglandin synthesis and antagonism of beta2-adrenergic receptors markedly attenuated the hyperalgesia induced by carrageenan, these interventions did not affect hyperalgesic priming. Tumor necrosis factor-alpha (rat recombinant; rrTNFalpha), another mediator of carrageenan-induced inflammation, alone produced hyperalgesia and priming, which were attenuated and prevented, respectively, by intrathecal administration of antisense to PKC epsilon. Inhibition of TNFalpha with thalidomide or a rat polyclonal anti-TNFalpha antibody attenuated carrageenan-induced hyperalgesia and prevented priming. Intrathecal administration of antisense to tumour necrosis factor receptor type-1 (TNFR1) reduced the level of TNFR1 transported toward the peripheral terminals of sensory neurons, and attenuated both carrageenan- and rrTNFalpha-induced priming. Acute hyperalgesia induced by carrageenan or rrTNFalpha remained intact in animals treated with TNFR1 antisense. Our results demonstrate that the generation of the primed state does not require production of hyperalgesia and that TNFalpha, which is generated during acute inflammation, can act on sensory neurons to induce hyperalgesic priming by activating neuronal PKC epsilon.
Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors (1992)

To cast light on the subunit composition of native NMDA-type glutamate receptors, four cloned subunits of the NMDA receptor have been expressed, in pairs, in Xenopus oocytes, and their single-channel properties have been measured. The conductances of the channels, and their characteristic patterns of sublevel transitions, turn out to be useful diagnostic criteria for subunit composition. The NR1-NR2A and NR1-NR2B combinations (which have identical TM2 sequences) are very similar to each other. Both have 50 pS openings and brief 40 pS sublevels (in 1 mM external Ca2+), with similar mean lifetimes and frequencies. They also show close quantitative resemblance to the channels of hippocampal CA1 and dentate gyrus cells and of cerebellar granule cells, except that the NR1-NR2A combination has a lower glycine sensitivity than the native channels. In contrast, the NR1-NR2C combination produces a channel with 36 pS and 19 pS conductances of similar (brief) duration; these closely resemble the 38-18 pS channels that have previously been observed in large cerebellar neurons in culture (together with 50 pS channels).
“SODIUM PERCARBONATE” (SPC) AS A HYDROGEN PEROXIDE SOURCE FOR ORGANIC SYNTHESIS (1986)

Abstract “Sodium percarbonate” (SPC) is an inexpensive, stable, safe and commercially available material which may be used as a hydrogen peroxide source for organic synthesis. Epoxidation, amine and sulfide oxidation reactions were simply performed with the solid reagent in moderate to excellent yield.
Inheritance of Kernel Hardness in Spring Wheat1 (1977)

An “inbred‐backcross” technique was used to study the inheritance of kernel hardness in two spring wheat ( Triticum aestivum L.) crosses. Seventy‐three inbred lines from the second backcross of ‘Pitic 62’ to ‘Neepawa’ and 91 inbred lines from the second backcross of ‘Glenlea’ to Neepawa were evaluated in four‐replicate randomized block experiments in each of 2 years. Grinding time was used as the measure of kernel hardness. The difference between Pitic 62, a soft wheat, and Neepawa, a hard wheat, was found to be governed by two major genes and one or more minor genes. A single major gene and one or more minor genes accounted for the difference in grinding time between Glenlea, a very hard wheat, and Neepawa.
Forces developed beneath hydrogel contact lenses due to squeeze pressure (1986)

The hydrodynamic squeeze pressure in the fluid thin film beneath hydrogel contact lenses fitted onto an axisymmetric model eye were measured. These pressures were due to the contact lens relaxing after deformation by an applied force of similar magnitude to the human eyelid force. The distribution of pressure for contact lenses typically fitted to human eyes was negative with respect to atmospheric pressure at the corneal apex and became less negative at the corneo-scleral limbus. The force that the contact lens applied to the cornea was determined by integrating the pressure distribution from the corneal apex to the limbus. This force varied from 6.0 X 10(-4) N to -7.8 X 10(-1) N depending on the thickness, elastic modulus and bearing relationship of the contact lens. An expression was derived to determine the pressure developed beneath the annulus of the hydrogel contact lens overlapping the cornea, in terms of the measured force over the cornea beneath the contact lens and the chord diameters of the contact lens and cornea. It was found that the deformation of hydrogel contact lenses on the model eye did not follow a linear elastic shell theory.
Experimental and clinical analysis of the characteristics of a chimeric monoclonal antibody, MOv18, reactive with an ovarian cancer-associated antigen. (1992)

Monoclonal antibody (Mab) MOv18 preferentially reacts with gynecological carcinomas. We have analyzed the characteristics of murine MOv18 (m-MOv18) and chimeric MOv18 (c-MOv18). We found no differences in affinity and binding to IGROV1 cells between c-MOv18 as IgG and F(ab')2 fragments and m-MOv18. In nude mice bearing IGROV1 xenografts, maximum tumor uptake 6-15 hr after i.v. injection of radiolabeled m-MOv18 IgG, c-MOv18 IgG, c-MOv18 F(ab')2 and a control IgG, 2C7, was 10%, 11%, 3% and 4.5% of the injected dose/g (%ID/g), respectively. M- and c-MOv18 IgG retained this level for several days, while c-MOv18 F(ab')2 and 2C7 cleared rapidly from the tumor. Uptake in normal tissues was low, with the exception of high uptake in kidneys for c-MOv18 F(ab')2. Tumor/blood ratios for c-MOv18 F(ab')2 were sixfold higher than for IgG. Radiation absorbed doses to tumor tissue delivered by 10 microCi iodinated m-MOv18 IgG, c-MOv18 IgG and c-MOv18 F(ab')2 were 39 cGy, 49 cGy and 5 cGy, respectively. A cocktail of 125I-c-MOv18 IgG and 131I-c-MOv18 F(ab')2 injected i.v. into an ovarian cancer patient, localized specifically in the tumor. Ovarian cancer tissue samples obtained 2 days postinjection showed a mean uptake of 1.2 x 10(-3) and 2.7 x 10(-3) %ID/g for c-MOv18 IgG and c-MOv18 F(ab')2, respectively. Results from these in vitro and in vivo experiments indicate that c-MOv18 has promise as a Mab for clinical use.
Behavioural biometrics: a survey and classification (2008)

This study is a survey and classification of the state-of-the-art in behavioural biometrics which is based on skills, style, preference, knowledge, motor-skills or strategy used by people while accomplishing different everyday tasks such as driving an automobile, talking on the phone or using a computer. The authors examine current research in the field and analyse the types of features used to describe different types of behaviour. After comparing accuracy rates for verification of users using different behavioural biometric approaches, researchers address privacy issues which arise or might arise in the future with the use of behavioural biometrics.
16S rRNA gene sequence-based analysis of clostridia related to conversion of germfree mice to the normal state (2009)

The results of this study can be applied in the strict control of mouse intestinal microbiota and will provide important information for normalization of GF mice and also for research on microbiology of the mouse intestine.
Activity and specificity of a mouse monoclonal antibody to ferric aerobactin (1992)

We isolated a monoclonal antibody directed against the ferric complex of aerobactin purified from Escherichia coli KH576. This antibody, which we designated MAb AERO1, was identified as an immunoglobulin G, subtype 2. A competitive enzyme-linked immunosorbent assay with MAb AERO1 had a limit of 10 nM for the detection of purified ferric aerobactin and allowed detection of the crude aerobactin produced by various members of the family Enterobacteriaceae isolated from cancer patients with bacteremia. The only two other structurally related siderophores recognized by MAb AERO1 were ferric arthrobactin and ferrioxamine B. These results suggest that the epitope recognized by MAb AERO1 was the lysyl moiety of ferric aerobactin. We also showed that MAb AERO1 reduced the growth of an aerobactin-producing strain of E. coli in newborn calf serum, which indicates that it might be effective in reducing the severity of infections caused by bacteria for which the production of aerobactin is an important virulence factor.