gebhart/patrepeval huggingface dataset:
Collecting Speech from Crowds (2013)

This chapter gives the reader the basic tools necessary to perform their own speech collection tasks. The first section begins by giving a short history of speech collection, describing how the field has progressed to date. It asserts that web-based speech collection, while not yet well explored, has the potential to vastly simplify audio collection efforts. It describes the current technology for microphone-enabled websites in second section and points to future technologies, such as HTML5, which promise to simplify the task even further. In third and fourth sections, The chapter provides an example audio recorder and server. The fifth section outlines the steps necessary to deploy this audio collection interface to mechanical turk (MTurk), to crowdsource the collection of speech. The sixth section talks about the usage of the platform purely for payment. The chapter concludes with a look to the future in the seventh section.
Alkylator resistance in human B lymphoid cell lines: (2). Increased levels of topoisomerase II expression and function in a melphalan-resistant B-CLL cell line. (2000)

Previous studies have demonstrated alkylating (melphalan) resistance in the B-CLL derived WSU-CLL cell line as compared to WIL2 B lymphocytic cells. Nuclear extracts from WSU-CLL cells demonstrate a highly significant increase in DNA topoisomerase II activity as compared to WIL2 cells. Western blot analysis showed the level of topoisomerase II proteins expressed in WSU-CLL cells to be increased as compared to WIL2 cells. WSU-CLL cells were 5.24-fold more sensitive than WIL2 cells to the cytotoxic effect of the topoisomerase II inhibitor doxorubicin. No difference in topoisomerase I activity or of the level of topoisomerase I protein expression was observed comparing the two cell lines. The sensitivity to the cytotoxic effects of topoisomerase I inhibitor, camptothecin, did not differ in WSU-CLL and WIL2 cell lines. Pre-incubation with doxorubicin significantly increased melphalan induced interstrand-DNA-crosslink formation and cytotoxicity in WSU-CLL cells as compared to WIL2 cells. The affinity of topoisomerase II for WSU-CLL UV-irradiated-crosslinked DNA was increased 2.84-fold as compared to that of WSU-CLL native DNA. The affinity of topoisomerase II for both UV-irradiated (crosslinked) and for native DNA was significantly decreased after doxorubicin-pretreatment. Measurement of DNA polymerase beta and DNA polymerase beta revealed significant elevations in DNA polymerase beta (58.82 +/- 3.67 units/mg protein in WSU-CLL cells, as compared to 27.82 +/- 4.39 units/mg protein in WIL 2 cells; p < 0.01) but not DNA polymerase beta (0.82 +/- 0.11 units/mg protein in WSU-CLL cells, compared to 0.74 +/- 0.09 units/mg protein in WIL2, p > 0.05). However, exposure to aphidicolin (an inhibitor of DNA polymerase a) failed to increase melphalan induced cytotoxicity suggesting that although DNA polymerase a activity was increased in WSU-CLL cells the mechanisms of resistance does not involve this specific DNA repair pathway. Elevated topoisomerase II activity and the increased affinity of topoisomerase II for crosslinked DNA in melphalan resistant cells appears to be the major factor responsible for alkylator resistance by changing DNA topology and thereby facilitating DNA repair.
Analytical method for multimode oscillators using the averaged potential (1983)

Abstract A method using the averaged potential is proposed for analyzing the oscillation in a multimode negative resistance oscillator. the averaging method is applied to the mixed potential defined by Brayton and Moser and a function called the averaged potential is introduced that expresses the average of the loss (dissipation) of the system. the averaged equations derived by applying the averaging method to the network equations can be expressed as the gradient system of the averaged potential. Hence, stable oscillation corresponds to a minimum of the averaged potential. the analysis of the system is reduced to constructing the averaged potential and to finding the minima. the physical meaning is clarified for the phenomenon of minimal loss of the system in a stable oscillation system. General rules of initiation of nonresonant multimode oscillations are derived because the averaged potential becomes a quadratic form when the chracteristic of an active device is expressed in terms of a polynomial of order three.
<title>Simultaneous multipoint fiber optic Raman sampling for chemical process control using diode lasers and a CCD detector</title> (1992)

A diode-laser-based portable Raman spectrometer is described that uses a 2-dimensional-array detector (charge-coupled device--CCD) to simultaneously measure chemical processes at several remote points using fiber optics. Optical multiplexing with the CCD allows simultaneous measurements with little loss of sensitivity and the low-energy near-visible (NVIS) excitation (e.g., 786 to 820 nm) prevents most sample luminescence. Several fiber- optic sensor configurations optimized for particular applications, including surface-enhanced Raman (SER), are presented. Applications are described including in-situ epoxy cure chemistry monitoring in a curing oven, monitoring a distillation apparatus, and mixed waste monitoring. Some of the limitations of the system are discussed.
Switching Current Fluctuation and Repeatability for MRAM With Propeller-Shape MTJ (2006)

The writing region and the repeatability of the function test and switching current fluctuation of magnetoresistive random access memory (MRAM) with a propeller shape magnetic tunnel junction (MTJ) array is evaluated. The effect of the write sequence is also investigated. The writing region is larger when the easy-axis field pulse is turned on prior to the hard-axis field than that in the case of the opposite sequence. However, the total margin in the latter sequence is larger after the repeated tests because of the smaller switching field fluctuation. The average 1-sigma value of the switching field fluctuation is 1.7%, which is mainly caused by the thermal fluctuation. The probability of the write error is estimated to be less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-16</sup> by the bit line writing region and the thermal stability
The Air-Damped Vibrating System: Theoretical Calibration of the Condenser Transmitter (1918)

3 This paper deals with the calibration at various frequencies in
Identification of Phosphatidylcholine-Phospholipase D and Activation Mechanisms in Rabbit Kidney Proximal Tubule Cells (1996)

The present study showed that receptor-mediated activation of rabbit kidney proximal tubule cells by angiotensin II, the ionophore A23187, or the protein kinase C activator phorbol myristate acetate (PMA) all stimulated phospholipase D (PLD). This was demonstrated by the increased formation of phosphatidic acid, and in the presence of 0.5% ethanol, phosphatidylethanol (PEt) accumulation. Angiotensin II leads to a rapid increase in phosphatidic acid and diacylglycerol, and phosphatidic acid formation preceeded the formation of diacylglycerol. This result suggests that some phosphatidic acid seems to be formed directly from phosphatidylcholine hydrolyzed by Pill. On the other hand, EGTA substantially attenuated angiotensin II and A23187-induced PEt formation, and when the cells were pretreated with verapamil angiotensin II-induced Pill activation was completely abolished. These results provide the evidence that calcium ion influx is essential for the agonist-induced Pill activation. In addition, staurosporine, an inhibitor of protein kinase C, strongly inhibited PMA-induced PEt formation, but was ineffective on angiotensin II-induced PEt accumulation. also stimulates PEt formation in digitonin-permeabilized cells, but pretreatment of the cells with pertussis toxin failed to suppress angiotensin II-induced PEt formation. From these results, we conclude that in the rabbit kidney proximal tubule cells the mechanisms of angiotensin II- and PMA-induced Pill activation are different from each other and mediated via a pertussis toxin-insensitive trimeric G protein.
NMDA Receptor Activation Increases Cyclic AMP in Area CA1 of the Hippocampus via Calcium/Calmodulin Stimulation of Adenylyl Cyclase (1993)

We observed previously that activation of N-methyl-D-aspartate (NMDA) receptors in area CA1 of the hippocampus, through either NMDA application or long-term potentiation (LTP)-inducing high-frequency stimulation (HFS), results in an increase in cyclic AMP. In the present study, we performed experiments to determine the mechanism by which NMDA receptor activation causes this increase in cyclic AMP. As the NMDA receptor-mediated increase in cyclic AMP is dependent upon extracellular calcium, we hypothesized that NMDA receptors are coupled to adenylyl cyclase (AC) via calcium/calmodulin. In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP). In intact hippocampal slices, W-7 and TFP blocked the increase in cyclic AMP levels caused by both NMDA application and HFS of Schaffer collateral fibers. Exposure of hippocampal slices to elevated extracellular potassium to induce calcium influx also caused increased cyclic AMP levels; the increase in cyclic AMP caused by high potassium was also blocked by W-7 and TFP. These data support the hypothesis that NMDA receptor activation is positively coupled to AC via calcium/calmodulin and are consistent with a role for cyclic AMP metabolism in the induction of NMDA receptor-dependent LTP in area CA1 of the hippocampus.
Comment on "Quantum key distribution with 1.25 Gbps clock synchronization" by J.C. Bienfang et al., quant-ph/0405097 (2004)

We analyze the significance for quantum key distribution (QKD) of free-space quantum communications results reported in a recent paper (J. C. Bienfang et al., quant-ph/0405097, hereafter referred to as "Bienfang et al."), who contrast the quantum communications rate of their partial QKD implementation (which does not produce cryptographically useful shared, secret keys) over a short transmission distance, with the secret bit rates of previous full QKD implementations over much longer distances. We show that when a cryptographically relevant comparison with previous results is made, the system described by Bienfang et al. would offer no advantages for QKD, contrary to assertions in their paper and in spite of its high clock rate. Further, we show that the claim made by Bienfang et al. that "high transmission rates serve ... to extend the distance over which a QKD system can operate" is incorrect. Our analysis illustrates an important aspect of QKD that is too often overlooked in experiments: the sifted bit rate can be a highly misleading indicator of the performance of a QKD system.
Association between human demodicosis and HLA class I (2003)

Demodex folliculorum and D. brevis are obligatory parasites in hair follicles and in pilosebaceous glands of human skin. Although most people are infested with these mites, only a small number develop the clinical symptoms of skin demodicosis. The objective of this study was to determine the association between HLA specificity and demodicosis. Twenty-five patients with human demodicosis and 150 controls were typed for HLA-A, B, Bw, and Cw using the microlymphocytotoxicity method. The immune response was evaluated by identifying membrane markers of different immune cells using monoclonal antibodies. An association between the frequency of HLA Cw2 and Cw4 haplotypes and human demodicosis was established. The risk of developing clinical symptoms of this disease is 5.0 times higher for people with the Cw2 phenotype and 3.1 times higher for those with the Cw4 haplotype. Individuals who have the HLA A2 phenotype are 2.9 times more resistant to demodicosis. A positive correlation between demodicosis and the haplotypes A3-Cw4, A3-Cw2, A3-B17, A3-B35 and B35-Cw4 was found. In addition, an association between Cw2 and Cw4 alleles in the phenotype of patients with demodicosis and a decrease in the number of natural killer cells was found.
Growth Factor Delivery to Re-Engineer Periodontal Tissues (2002)

Repair of tooth-supporting structures destroyed by the chronic inflammatory disease periodontitis is a major goal of oral therapy. The field of tissue engineering combines materials science and biology to repair tissues and organs. Periodontal tissue engineering has been achieved with limited success by the utilization of guiding tissue (cell occlusive) membranes and bone grafting techniques. Over the past decade investigators have begun to utilize signaling molecules such as growth factors to restore lost tooth support due to periodontitis, the most common bone disease affecting humans. This review will provide information on the status of growth factor therapies being applied in periodontology to treat advanced alveolar bone loss.
Longitudinal assessment of changes in reproductive hormones during normal pregnancy (1991)

The concentrations of hormones measured in serum from maternal blood change dramatically during pregnancy. While the relative contributions of sex steroids shift from maternal ovaries and adrenals to the fetoplacental unit, other maternal tissues such as pituitary and liver respond to increasing concentrations of estrogen and secrete increasing amounts of prolactin and sex-hormone-binding globulin. To determine longitudinal changes in circulating maternal hormones, we collected blood from 60 women on three occasions during their pregnancies. We observed a 1.7-fold increase in testosterone concentration in serum; concentrations of sex-hormone-binding globulin in serum rose 5.6-fold. The major increase (6.8-fold) in estradiol in serum occurred within the first 16 weeks, followed by a further 4.8-fold increase by term. Mean concentrations of progesterone, 17-hydroxyprogesterone, and androstenedione in serum increased 11.9-, 3-, and 1.3-fold, respectively, whereas concentrations of dehydroepiandrosterone sulfate (DHEAS) fell by 50%. Mean serum prolactin concentrations increased 3.8-fold during the first trimester and by a similar amount during the final 24 weeks of pregnancy. We used these data, obtained from a cohort of women with uncomplicated pregnancies, to construct reference intervals for hormones in maternal serum.
Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity (2013)

We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently inhibited proliferation of folate receptor (FR) α-expressing Chinese hamster ovary and KB human tumor cells. Growth inhibition was reversed completely or in part by excess folic acid, indicating that FRα is involved in cellular uptake, and resulted in S-phase accumulation and apoptosis. Antiproliferative effects of compound 8 toward KB cells were protected by excess adenosine but not thymidine, establishing de novo purine nucleotide biosynthesis as the targeted pathway. However, 5-aminoimidazole-4-carboxamide (AICA) protection was incomplete, suggesting inhibition of both AICA ribonucleotide formyltransferase (AICARFTase) and glycinamide ribonucleotide formyltransferase (GARFTase). Inhibition of GARFTase and AICARFTase by compound 8 was confirmed by cellular metabolic assays and resulted in ATP pool depletion. To our knowledge, this is the first example of an antifolate that acts as a dual inhibitor of GARFTase and AICARFTase as its principal mechanism of action.
Oracle 8 : a beginner's guide (1997)

From the Publisher:
A concise comprehensive survey of Oracle8 for novice users. Features the new Network Computing Architecture revealed!
At lasta concise,comprehensive survey of Oracle8 for novice users! 
Begin your exploration of Oracle with expanded coverage of the revolutionary new Oracle8. Oracle 8: A Beginner's Guide will introduce you to the essential concepts behind the latest version of this complex and powerful database management system  and will teach you the basics of setting up,querying,and managing your database. 
In this official guide,authorized by Oracle Corporation and written by two renowned members of the Oracle community,database experts Michael Abbey and Michael J. Corey discuss: 

Oracle8's new object environment and object-oriented programming concepts,data warehousing,and Oracle's Network Computing Architecture with an emphasis on Windows NT Basic to advanced SQL,and the principles of database design Oracle tools,showing you how to create tables; how to add search through,query,and sort data; and how to generate reports Management of your database and how to unravel the mysteries of tuning the system for optimal performance Developer/2000 Forms,Reports,and SQL Loader,as well as provide a guide to Oracle's latest products Oracle Enterprise manager and how it fits so well into the database administrator's toolset Key information on Oracle 8's object-relational technology and the Network Computing Architecture 


If you're looking for the single best introduction to Oracle8 Server and the key products related to it,look no further than Oracle8: A Beginner's Guide.
The Use of Ornithine Salts of Branched-Chain Ketoacids in Portal-Systemic Encephalopathy (1980)

In eight patients with chronic portal-systemic encephalopathy who were symptomatic despite protein restriction and lactulose, a double-blind crossover comparison was conducted of branched-chain amino acids (68 mmol/d) versus ornithine salts of branched-chain ketoacids (34 mmol/d), both mixtures being administered orally for 7 to 10 days, after control periods, during a single hospitalization. Ornithine salts of branched-chain ketoacids markedly improved electroencephalographic abnormalities and clinical grade of encephalopathy; branched-chain amino acids had significantly lesser effects, which were of borderline statistical significance. To ascertain whether ornithine or branched-chain ketoacids were responsible for the improvement observed, we administered to six patients calcium salts of branched-chain ketoacids (34 mmol/d) after control periods; only slight improvement was seen.. Four patients received a daily dose of ornithine alpha-ketoglutarate containing the same quantity of ornithine; one did not change and three deteriorated rapidly. We conclude that the combination of ornithine and branched-chain ketoacids improves chronic portal-systemic encephalopathy more than its components given separately and more than branched-chain amino acids at twice the molar dose.
Biosynthesis of Polyketides in Heterologous Hosts (2001)

Polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but architecturally diverse family of multifunctional enzymes called polyketide synthases. A principal limitation for fundamental biochemical studies of these modular megasynthases, as well as for their applications in biotechnology, is the challenge associated with manipulating the natural microorganism that produces a polyketide of interest. To ameliorate this limitation, over the past decade several genetically amenable microbes have been developed as heterologous hosts for polyketide biosynthesis. Here we review the state of the art as well as the difficulties associated with heterologous polyketide production. In particular, we focus on two model hosts, Streptomyces coelicolor and Escherichia coli. Future directions for this relatively new but growing technological opportunity are also discussed.
Studies in Red Blood Cell Preservation10.(51)Cr Recovery of Red Cells afterLiquid Storage in a Glycerol-ContainingAdditive Solution (1996)

The purpose of the present study was to compare the 24-hour recovery of red blood cells stored for 9 weeks in a hypoosmolar additive solution containing 150 mM glycerol to cells stored in Adsol®. Seven units of packed red cells were split into 2 aliquots. To one sample, 100 ml of the experimental additive solution (EAS 25) was added, and to the other, 50 ml of Adsol. At the end of the storage period the cells were labeled with 5lCr. A double chromium technique was used to make it possible to perform comparative autologous studies in the same donor. The 24-hour 51 Cr recovery value for EAS 25 was 73.0±(SD) 4.2% and for Adsol 60.9±7.1. At 9 weeks the adenosine triphosphate levels were not significantly better compared to Adsol but the other in vitro measurements were better. New approaches to the study of red cell preservation are suggested.
Chimeric Antigen Receptor T-cell Therapy to Target Hematologic Malignancies (2014)

Several decades of humoral immunotherapy using monoclonal antibodies and cellular immunotherapy using hematopoietic cell transplantation have recently culminated in a successful merger: the development and clinical application of genetically engineered antibody-T cell chimeras. Also known as chimeric antigen receptor T cells (CAR T cells), these entities combine the exquisite antigen specificity of antibodies with the polyfunctionality and potency of cellular immunity and are a prime example of the potential for synthetic biology to treat disease. CAR T cells overcome several of the biologic obstacles that have historically hampered immunotherapy while providing fundamental mechanistic insights into cellular immunology and revealing new challenges in genetic engineering and target selection. Results from early-phase CAR T-cell-based clinical trials demonstrate the significant potential for this approach to affect dramatic and complete clinical responses while revealing novel toxicities associated with activation of potent and specific antitumor immunity.
SSD bufferpool extensions for database systems (2010)

High-end solid state disks (SSDs) provide much faster access to data compared to conventional hard disk drives. We present a technique for using solid-state storage as a caching layer between RAM and hard disks in database management systems. By caching data that is accessed frequently, disk I/O is reduced. For random I/O, the potential performance gains are particularly significant. Our system continuously monitors the disk access patterns to identify hot regions of the disk. Temperature statistics are maintained at the granularity of an extent, i.e., 32 pages, and are kept current through an aging mechanism. Unlike prior caching methods, once the SSD is populated with pages from warm regions cold pages are not admitted into the cache, leading to low levels of cache pollution. Simulations based on DB2 I/O traces, and a prototype implementation within DB2 both show substantial performance improvements.
Inflammation in Carotid Atherosclerotic Plaque: A Dynamic Contrast-enhanced MR Imaging Study (2006)

The correlations between Ktrans and histologic markers of inflammation suggest that Ktrans is a quantitative and noninvasive marker of plaque inflammation, which is further supported by the correlation of Ktrans with proinflammatory cardiovascular risk factors, decreased high-density lipoprotein levels, and smoking.
Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs. (1993)

SPM-5185 reduces myocardial necrosis and neutrophil accumulation in an acute model of canine myocardial ischemia and reperfusion. This reduction in myocardial cell injury may be partially related to the inhibitory actions of this novel NO donor on neutrophil adherence to the coronary endothelium.