gebhart/patrepeval huggingface dataset:
Promoter Hypermethylation Identifies Progression Risk in Bladder Cancer (2007)

Promoter hypermethylation seems a reliable predictor of tumor progression in bladder cancer. It is associated with aggressive tumors and could be used to identify patients with either superficial disease requiring radical treatment or a low progression risk suitable for less intensive surveillance. Multicenter studies are warranted to validate this marker.
The Role of the Legislature in Guidelines Sentencing in the "Other Washington" (1993)

Washington's legislature crafted a sentencing system which structures but does not eliminate discretionary decisions affecting sentences. Washington has a Sentencing Guidelines Commission which functions as an agent of the legislature and not as an independent actor. Data collected by the Sentencing Guidelines Commission since 1985 demonstrate the effectiveness of Washington's sentencing guidelines in translating the legislature's sentencing policy judgments into reality. The legislature's role in formulating and refining sentencing policies is examined in detail, as well as Washington's Sentencing Reform Act of 1981 and its effect on sentencing.
Adsorption and decomposition of organophosphorus compounds on nanoscale metal oxide particles. In situ GC-MS studies of pulsed microreactions over magnesium oxide (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption and decomposition of organophosphorus compounds on nanoscale metal oxide particles. In situ GC-MS studies of pulsed microreactions over magnesium oxideYong Xi Li, Olga Koper, Maher Atteya, and Kenneth J. KlabundeCite this: Chem. Mater. 1992, 4, 2, 323–330Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/cm00020a019https://doi.org/10.1021/cm00020a019research-articleACS PublicationsRequest reuse permissionsArticle Views514Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Measurements of acceleration during videofluorographic evaluation of dysphagic patients (2000)

Accelerometry represents a noninvasive technique for the assessment of the swallowing mechanism. However, the underlying physiological events that give rise to the acceleration signal are poorly understood. In the present study, the acceleration signal was measured simultaneously during videofluorography examination. Preliminary results revealed that the signal occurred during laryngeal elevation and the magnitude of acceleration correlated well with the laryngeal displacement. Acceleration measurements present a potentially useful noninvasive tool.
A 4Mb DRAM with cross point trench transistor cell (1986)

This report will describe the design of a 9.8mm×10.2mm 1MW×4b DRAM fabricated in a 1μm double-level metal CMOS technology featuring trench-transistor cells measuring 9μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Row and static column access times are 170ns and 30ns, respectively.
Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress (1998)

Hypertension increases mechanical force on the arterial wall by as much as 30%, resulting in marked alterations in signal transductions and gene expression in vascular smooth muscle cells (VSMCs) that contribute to matrix protein synthesis, cell proliferation, and differentiation. How the mechanical stimuli are converted into a biological signal in cells has yet to be studied. We investigated the role of both cyclic strain and shear stresses in initiating the cellular signaling on cultured VSMCs and found that mechanical forces evoked activation of mitogen-activated protein kinases, followed by enhanced DNA binding activity of transcription factor AP-1. Physical forces rapidly induced phosphorylation of platelet-derived growth factor receptor (PDGFR) alpha, an activated state. When GRB2, an adapter protein, was immunoprecipitated from treated VSMCs followed by Western blot analysis with anti-phosphotyrosine, -PDGFR alpha, and -GRB2 antibodies, respectively, phosphotyrosine positive staining was observed on PDGFR alpha bands of the same blot in stretch-stressed VSMCs, supporting the mechanical stress-induced activation of PDGFR alpha. Conditioned medium from stretch-stressed VSMCs did not result in PDGFR alpha phosphorylation, and antibodies binding to all forms of PDGFs did not block stress-induced PDGFR alpha activation. Thus, mechanical stresses may directly perturb the cell surface or alter receptor conformation, thereby initiating signaling pathways normally used by growth factors.
Ecofriendly Iodination of Activated Aromatics and Coumarins Using Potassium Iodide and Ammonium Peroxodisulfate (2010)

Corrected by: Ecofriendly Iodination of Activated Aromatics and Coumarins Using Potassium Iodide and Ammonium PeroxodisulfateSynthesis 2011; 2011(05): 828-828DOI: 10.1055/s-0030-1258441
Early Tau Pathology Involving the Septo-Hippocampal Pathway in a Tau Transgenic Model: Relevance to Alzheimers Disease (2009)

Alzheimer's disease is a neurodegenerative disorder characterized by amyloid deposits and neurofibrillary tangles. Cholinergic dysfunction is also a main pathological feature of the disease. Nevertheless, the links between cholinergic dysfunction and neuropathological hallmarks of Alzheimer's are still unknown. In the present study, we aimed to further investigate Tau aggregation in cholinergic systems, in a Tau transgenic mouse model. THY-Tau22 mice have recently been described as a novel model of Alzheimer-like Tau pathology without motor deficits. This strain presents an age-dependent development of Tau pathology leading to synaptic dysfunctions as well as learning and memory impairments. In the present work, we observed that Tau pathology differentially affects cerebral structures. Interestingly, early Tau pathology was observed in both hippocampus and basal forebrain. Moreover, some morphological as well as functional alterations of the septohippocampal pathway suggest a disconnection between these two key brain regions in Alzheimer's disease. Finally, these data suggest that Tau pathology may participate in cholinergic degeneration.
To BDNF or Not to BDNF: That Is the Epileptic Hippocampus (2005)

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has drawn much attention as a potential therapeutic target for temporal lobe epilepsy (TLE). TLE seizures are produced by synchronized hyperactivity of neuron populations due to the disruption of a balance between excitatory and inhibitory synaptic transmissions. In epileptogenesis-related brain areas, including the hippocampus, BDNF is up-regulated in the course of the development of epilepsy and induces a collapse of balanced excitation and inhibition, eventually exerting its epileptogenic effects. On the other hand, several reports demonstrate that intrahippocampal infusion of BDNF can attenuate (or retard) the development of epilepsy. This antiepileptogenic effect seems to be mediated mainly by an increase in the expression of neuropeptide Y. These contrasting effects of BDNF have prevented us from concluding whether inhibition or enhancement of BDNF signaling finally achieves the prevention of TLE. To address this question, it is essential to evaluate how BDNF changes its influences depending on conditions, for example, cell specificity, neural networks, and expression timing and loci. In this article, the authors review BDNF-induced acute and long-lasting changes seen in epileptic circuits from the anatomical and functional points of view.
Quinones and related compounds in higher plants. II. On the naphthoquinones and related compounds from Catalpa wood. (1975)

As the naphthoquinones and a derivative relating to the already reported catalpalactone (1), the following seven substances have been isolated from Catalpa ovata wood : α-lapachone (3), α-dihydrocaryopterone (=9-hydroxy-α-lapachone) (4), 9-methoxy-α-lapachone (5), 4-hydroxy-α-lapachone (6), 4, 9-dihydroxy-α-lapachone (7), 4-oxo-α-lapachone (8) and catalponol (9). Their sturctures, except catalponol (9) have been clarified.
Phospholipid monolayers at non-polar oil/water interfaces. Part 1.—Phase transitions in distearoly-lecithin films at the n-heptane aqueous sodium chloride interface (1976)

Using compression techniques, surface pressure (II) against area (A) isotherms are measured as a function of temperature for insoluble monolayers of 1,2-distearoyl-sn-glycero-3-phosphorylcholine spread at the n-heptane/aqueous sodium chloride interface. Problems of spreading are resolved and accurate results at moderate and high II are presented. The results show an almost first order phase change which is very temperature sensitive. Various forms of the Clapeyron analysis are applied to the data to calculate the heats of the phase change and to assess variations arising from the choice of a close-packed area. These heats vary with temperature but not with salt concentration or pH over the range studied. Results on 1,2-dioleoyl-sn-glycero-3-phosphorylcholine show no such phase changes.
Do Plant Cyclotides Have Potential As Immunosuppressant Peptides? (2012)

Cyclotides are an abundant and diverse group of ribosomally synthesized plant peptides containing a cyclic cystine-knotted structure that confers them with remarkable stability. They are explored for their distribution in plants, although little is known about the individual peptide content of a single species. Therefore, we chemically analyzed the crude extract of the coffee-family plant Oldenlandia affinis using a rapid peptidomics workflow utilizing nano-LC-MS, peptide reconstruct with database identification, and MS/MS automated sequence analysis to determine its cyclotide content. Biologically, cyclotides are mainly explored for applications in agriculture and drug design; here we report their growth-inhibiting effects on primary cells of the human immune system using biological and immunological end points in cell-based test systems. LC-MS quantification of the active O. affinis plant extract triggered the characterization of the antiproliferative activity of kalata B1, one of the most abundant cyclotides in this extract, on primary activated human lymphocytes. The effect has a defined concentration range and was not due to cytotoxicity, thus opening a new avenue to utilize native and synthetically optimized plant cyclotides for applications in immune-related disorders and as immunosuppressant peptides.
Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and Alzheimer disease brains (2000)

Assimilated evidence indicates that the neurotoxic potential of amyloid beta (Abeta) peptide and an alteration in the level of growth factor(s) may possibly be involved in the loss of neurons observed in the brain of patients suffering from Alzheimer disease (AD), the prevalent cause of dementia in the elderly. In the present study, using receptor binding assays and immunocytochemistry, we evaluated the pharmacological profile of insulin-like growth factor-I (IGF-I) receptors and the distribution of IGF-I immunoreactivity in the frontal cortex, hippocampus, and cerebellum of AD and age-matched control brains. In control brains, [(125)I]IGF-I binding was inhibited more potently by IGF-I than by Des(1-3)IGF-I, IGF-II or insulin. The IC(50) values for IGF-I in the frontal cortex, hippocampus, and cerebellum of the normal brain did not differ significantly from the corresponding regions of the AD brain. Additionally, neither K(D) nor B(max) values were found to differ in the hippocampus of AD brains from the controls. At the regional levels, [(125)I]IGF-I binding sites in the AD brain also remained unaltered compared to the controls. As for the peptide itself, IGF-I immunoreactivity, in normal control brains, was evident primarily in a subpopulation of astrocytes in the frontal cortex and hippocampus, and in certain Purkinje cells of the cerebellum. In AD brains, a subset of Abeta-containing neuritic plaques, apart from astrocytes, exhibit IGF-I immunoreactivity. These results, taken together, suggest a role for IGF-I in compensatory plasticity and/or survival of the susceptible neurons in AD brains.
Dietary Protein and Bone Health: Roles of Amino Acid–Sensing Receptors in the Control of Calcium Metabolism and Bone Homeostasis (2008)

In this article, we review the evidence that dietary protein has a positive influence on bone health, reduces hip fracture risk, and promotes postfracture recovery, and we consider the molecular, cellular, and endocrine bases of the interactions that link protein and calcium metabolism, including effects via IGF-1 and PTH. In addition, we consider the roles of amino acid-sensing mechanisms in coupling dietary protein intake to metabolic change as well as the central role of calcium-sensing receptors (CaRs) in the control of calcium metabolism. Finally, we consider how recently identified broad-spectrum amino acid-sensing receptors from class 3 of the G-protein coupled receptor superfamily including, remarkably, the CaR itself may contribute to the impact of dietary protein on bone.
Generation of Compact Near-Field Energy for Optical Recording: Transducer Efficiency and Signal Detection (2003)

A new theory of illumination is derived for near-field optical transducers, in which transmitted power is related to total power in the illuminating laser beam. Several transducers are compared, including simple holes in metallic films, a dielectric probe and solid immersion lens combination, and plasmon-enhanced holes. The ratio of transmitted power to incident power is a function of the illumination numerical aperture, due to the angular selectivity of the transducers. Also, a simplified collection theory is reviewed, which reveals that, when transducers are used for the collection of data signals in optical storage applications, a combination of the transducer and a solid immersion lens provides a large angular collection range, and hence a good contrast signal.
<title>RXI concentrator for 1000X photovoltaic energy conversion</title> (1999)

The purpose of this work is to present the measurements of the main characteristics of a series of RXI concentrators developed: angular transmission, acceptable angle, optical efficiency, and optical concentration. The RXI concentrator has been designed with the Simultaneous Multiple Surfaces method developed by Minano et al. at the Instituto de Energia Solar--Universidad Politecnica de Madrid. The design characteristics are: geometric concentration 1256X, acceptance angle 1.8 degree(s).
[Observation on therapeutic effect of acupuncture combined with medicine on mild cognition disorders in patients with post-stroke]. (2012)

Acupuncture can improve activity of daily living and has significant effect in treating mild cognition disorders after stroke without adverse reactions.
Effects of N-substitution on the activation mechanisms of 4-hydroxycyclophosphamide analogs (1989)

The activation mechanisms of the N-substituted 4-hydroxycyclophosphamide analogues 4-hydroxyifosfamide (2b), 4-hydroxytrofosfamide (2c), and 3-methyl-4-hydroxycyclophosphamide (2d) were compared with that of the unsubstituted parent compound 2a. The reaction kinetics of cis-2b, -2c, and -2d are qualitatively similar to those of 2a in that they undergo ring opening to the respective aldophosphamide intermediates 3, which can reclose to the cis- or trans-4-hydroxy isomers or undergo base-catalyzed beta-elimination to generate the corresponding phosphoramide mustard products 4. In contrast to the general acid catalysis observed for ring opening of 2a and 2d, the N-(chloroethyl)-substituted analogues 2b and 2c undergo specific base-catalyzed ring opening. This mechanistic difference was also illustrated by the rapid reaction of 2a and 2d with sodium 2-mercaptoethanesulfonate (Mesna) under acidic conditions to give the 4-(alkylthio)-substituted cyclophosphamide derivatives 5a and 5d. Compounds 2b and 2c did not react with Mesna to generate 5b and 5c under these conditions. Both the fraction of aldehyde/hydrate present at equilibrium and the cytotoxicity against L1210 cells in vitro decreased in the order 2c greater than 2b greater than 2a greater than 2d. The plasma-catalyzed acceleration of phosphoramide mustard generation previously reported for 2a was also observed for these analogues.
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis (2009)

ABL1 has been implicated in multiple processes including cell division, cell adhesion and cellular stress response. These results suggest that characterization of the function of genetic variation in this gene in other ovarian cancer populations is warranted.
Lipid‐Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery (2013)

Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
Slit-scanning confocal microendoscope for high-resolution in vivo imaging (1999)

We discuss the design and construction of a novel imaging system in which a fiber-optic imaging bundle and miniature optical and mechanical components are used to allow confocal fluorescence microscopy in remote locations. The instrumentation has been developed specifically for cellular examination of tissue for optical biopsy. Miniaturization of various components makes the device usable in a clinical setting. The numerical aperture of the beam in the tissue is 0.5, and the field of view is 430 microm. The measured lateral resolution of the system is 3.0 microm. The axial point and the axial planar response functions of the confocal system were measured with a FWHM of 10 and 25 microm, respectively. In vitro and in vivo images obtained with cell cultures, human tissue specimens, and animal models indicate that the performance of the device is adequate for microscopic evaluation of cells.
Dynamic programming, the viterbi algorithm, and low cost speech recognition (2005)

Dynamic Programming, the Viterbi Algorithm, the theory of finite state machines, and the mathematics of Markov processes are well developed formalisms that can be applied to the problem of pattern matching acoustic events in speech. At the intersection of these formalisms are a set of computationally efficient but powerful algorithms that are a significant improvement over the commonly used pattern matching schemes for handling temporal and spacial deviation from idealized prototypes. This paper will describe some of these relatively new pattern matching algorithms. It will be shown that they reduce to simple forms that promote low cost isolated word and continuous speech recognition.
The ARPANET after Twenty Years (1989)

The ARPANET began operations in 1969 with four nodes as an experiment in resource sharing among computers. It has evolved into a worldwide research network of over 60,000 nodes, influencing the design of other networks in business, education, and government. It demonstrated the speed and reliability of packet-switching networks. Its protocols have served as the models for international standards. And yet the significance of the ARPANET lies not in its technology, but in the profound alterations networking has produced in human practices. Network designers must now turn their attention to the discourses of scientific technology, business, education, and government that are being mixed together in the milieux of networking, and in particular the conflicts and misunderstandings that arise from the different world views of these discourses.
A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins (1993)

A clone, designated pag, was isolated by differential screening of cDNA libraries made from the untransformed and ras-transformed human mammary epithelial cell line HBL100. This cDNA corresponds to a gene constitutively expressed in most human cells which is induced to higher levels upon serum stimulation in untransformed and ras-transformed HBL100 cells. However, the abundance of the pag transcript is approximately 3-fold higher in transformed as compared to untransformed cells after 7-15 h of serum stimulation. In the promyelocytic leukemia cell line HL60 induced to differentiate the level of pag mRNA starts to decrease between 48 and 72 h following induction. During this period, which represents the commitment phase of differentiation, HL60 cells cease to proliferate. Therefore, in HBL100 and HL60 cells, higher levels of pag gene expression are correlated with cell proliferation. The pag cDNA codes for a 22-kDa protein, devoid of known consensus motifs, and shares 66% homology with a murine gene product (MER5) that is preferentially expressed in erythroleukemia cells during the early period of cell differentiation. In addition, the pag gene product shares approximately 50% identity with a 29-kDa surface antigen of Entamoeba histolytica and a 26-kDa antigen of Helicobacter pylori. Distant relationship was also found with other prokaryotic proteins. The pag cDNA hybridizes to multiple sequences within human and other mammalian genomes and to fewer sequences in chicken and Saccharomyces cerevisiae. Although a true relationship between eukaryotic and prokaryotic genes is difficult to establish, the conservation of pag gene sequences throughout Eukaryotae rather suggests that the pag locus belongs to a new class of genes encoding highly conserved proteins.
Injectable rhBMP‐2‐loaded chitosan hydrogel composite: Osteoinduction at ectopic site and in segmental long bone defect (2010)

Carriers for bone morphogenetic protein-2 (BMP-2) used in clinical practice still suffer from limitations such as insufficient protein retention. In addition, there is a clinical need for injectable carriers. The main objective of this study was to assess bone forming ability of rhBMP-2 combined either with chitosan hydrogel (rhBMP-2/CH) or chitosan hydrogel containing β-tricalcium phosphate (β-TCP) (rhBMP-2/CH/TCP). Formulations were first compared in a rat ectopic intramuscular bone formation model, and the optimal formulation was further evaluated in healing of 15-mm critical size defect in the radius of a rabbit. Three weeks after injection ectopically formed bone was analyzed by microcomputerized tomography (micro-CT) and histology. Significantly higher (4.7-fold) mineralized bone formation was observed in the rhBMP-2/CH/TCP group compared to rhBMP-2/CH group. In a pilot study, defect in a rabbit radius treated with rhBMP-2/CH/TCP showed incomplete regeneration at 8 weeks with composite leakage from the defect, indicating the need for formulation refinement when segmental defect repair is foreseen.