gebhart/patrepeval huggingface dataset:
Development and Validation of the Social Emotional Competence Questionnaire (SECQ) (2012)

Reliable and valid measures of children's and adolescents' social emotional competence (SEC) are necessary to develop in order to assess their social emotional development and provide appropriate intervention in child and adolescent development. A pool of 25 items was created for the Social Emotional Competence Questionnaire (SECQ) that represented five dimensions of SEC: self-awareness, social awareness, self-management, relationship management and responsible decision-making. A series of four studies are reported relating to the development and validation of the measure. Confirmatory factor analyses of the responses of 444 fourth-graders showed an acceptable fit of the model. The model was replicated with another 356 secondary school students. Additional studies revealed good internal consistency. The significant correlations among the five SEC components and academic performance provided evidence for the predictive validity of the instrument. With multiple samples, these results showed that the scale holds promise as a reliable, valid measure of SEC.
Construction and alignment of a high performance multipass vernier tandem Fabry–Perot interferometer (1981)

A multipass vernier tandem Fabry–Perot interferometer is easily constructed and aligned when the two scanning mirrors are mounted on a common scanning stage. Using such a system we obtain an ultimate resolution of 10−3cm−1 and a maximum scanning range, free of overlapping orders, of ≳50 cm−1. Using a 5 plus 4 pass arrangement a contrast ≫10 is obtained which, together with a high overall luminosity, permits simultaneous resolution of both weak spectral features near zero energy shift and low-frequency Raman bands. In addition to constructional details of this system we discuss the alignment procedure for uniform transmission in tandem operation, and demonstrate how the alignment requirments ultimately limit the performance of any tandem system to an ’’effective finesse’’ of &amp;lt;1000. Spectra showing surface waves in silicon and shear waves in polystyrene illustrate the power of this technique.
Colorectal cancer. (1992)

Two current areas of interest regarding colorectal cancer are identification of its genetic and environmental causes, and evaluation of the possibilities of implementing screening programmes for asymptomatic disease in the general population. These issues are addressed in the various studies outlined in this update.
EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy (2009)

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tumors from patients treated with the EGFR inhibitor lapatinib revealed that EGFR induces the cleavage and nuclear translocation of the master transcriptional regulator of fatty acid synthesis, sterol regulatory element-binding protein 1 (SREBP-1). This response was mediated by Akt; however, clinical data from rapamycin-treated patients showed that SREBP-1 activation was independent of the mammalian target of rapamycin complex 1, possibly explaining rapamycin's poor efficacy in the treatment of such tumors. Glioblastomas without constitutively active EGFR signaling were resistant to inhibition of fatty acid synthesis, whereas introduction of a constitutively active mutant form of EGFR, EGFRvIII, sensitized tumor xenografts in mice to cell death, which was augmented by the hydroxymethylglutaryl coenzyme A reductase inhibitor atorvastatin. These results identify a previously undescribed EGFR-mediated prosurvival metabolic pathway and suggest new therapeutic approaches to treating EGFR-activated glioblastomas.
Sources of evidence for vertical selection (2009)

Web search providers often include search services for domain-specific subcollections, called verticals, such as news, images, videos, job postings, company summaries, and artist profiles. We address the problem of vertical selection, predicting relevant verticals (if any) for queries issued to the search engine's main web search page. In contrast to prior query classification and resource selection tasks, vertical selection is associated with unique resources that can inform the classification decision. We focus on three sources of evidence: (1) the query string, from which features are derived independent of external resources, (2) logs of queries previously issued directly to the vertical, and (3) corpora representative of vertical content. We focus on 18 different verticals, which differ in terms of semantics, media type, size, and level of query traffic. We compare our method to prior work in federated search and retrieval effectiveness prediction. An in-depth error analysis reveals unique challenges across different verticals and provides insight into vertical selection for future work.
Sleep (1984)

Disturbances of sleep have been well established in depressive states as a result of studies carried out around fifteen or so years ago (Oswald et al., 1963; Zung et al., 1964; Mendels and Hawkins, 1967). In particular, NREM sleep tends to be decreased, there are changes in REM sleep patterns (e.g. decreased latency to first REM period, increased or decreased REM sleep), and sleep stages 3 and 4 are reduced. There is an increase in the number of wakenings. In manic states similar changes may occur (Hartmann, 1968). It is, therefore, only to be expected that in patients receiving lithium treatment sleep changes will occur in parallel with clinical improvement. It may be that the sleep patterns characteristic of affective dysfunctional states are consequences of the psychiatric disturbance, in which case the observed sleep changes during lithium therapy are not particularly interesting as clues to the mechanisms of lithium action. If, however, affective disorders and sleep disturbances are more closely linked in terms of their causative mechanisms (see pp. 211–225) then it may be that lithium directly affects sleep control processes. This possibility is enhanced by the fact that lithium produces a variety of electroencephalographic effects in both normal volunteers and animals (Dimitrakoudi and Jenner, 1975).
Protein Extraction From Plant Tissues (2004)

Plant tissues contain a wide range of proteins, which vary greatly in their properties, and require specific conditions for their extraction and purification. It is therefore not possible to recommend a single protocol for extraction of all plant proteins.
Cytosolic Delivery and Characterization of the TcdB Glucosylating Domain by Using a Heterologous Protein Fusion (2001)

TcdB from Clostridium difficile glucosylates small GTPases (Rho, Rac, and Cdc42) and is an important virulence factor in the human disease pseudomembranous colitis. In these experiments, in-frame genetic fusions between the genes for the 255 amino-terminal residues of anthrax toxin lethal factor (LFn) and the TcdB(1-556) coding region were constructed, expressed, and purified from Escherichia coli. LFnTcdB(1-556) was enzymatically active and glucosylated recombinant RhoA, Rac, Cdc42, and substrates from cell extracts. LFnTcdB(1-556) plus anthrax toxin protective antigen intoxicated cultured mammalian cells and caused actin reorganization and mouse lethality, all similar to those caused by wild-type TcdB.
Block-based web search (2004)

Multiple-topic and varying-length of web pages are two negative factors significantly affecting the performance of web search. In this paper, we explore the use of page segmentation algorithms to partition web pages into blocks and investigate how to take advantage of block-level evidence to improve retrieval performance in the web context. Because of the special characteristics of web pages, different page segmentation method will have different impact on web search performance. We compare four types of methods, including fixed-length page segmentation, DOM-based page segmentation, vision-based page segmentation, and a combined method which integrates both semantic and fixed-length properties. Experiments on block-level query expansion and retrieval are performed. Among the four approaches, the combined method achieves the best performance for web search. Our experimental results also show that such a semantic partitioning of web pages effectively deals with the problem of multiple drifting topics and mixed lengths, and thus has great potential to boost up the performance of current web search engines.
A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation (2005)

The p53 tumor suppressor is a transcription factor that is activated by diverse genotoxic and cytotoxic stresses. Upon activation, p53 prevents the proliferation of genetically unstable cells by regulating the expression of genes that initiate cell cycle arrest, apoptosis, and DNA repair. Consequently, p53 must be kept inactive in unstressed cells as its inappropriate activation can cause premature senescence and death. p53 inhibition occurs primarily through the E3 ubiquitin ligase, MDM2. Because MDM2 is also a p53 target gene, stresses paradoxically activate p53 while simultaneously increasing MDM2 expression. Therefore, a challenge has been to explain how the abundant MDM2 is prevented from inhibiting p53, thus ensuring that p53 can execute an appropriate stress response. Here we discuss a new mechanism for p53 activation involving DNA damage-induced auto-degradation of MDM2. Our data reveal that DNA damage leads to the destabilization of MDM2, which correlates with p53 stabilization and target gene induction. Conversely, p53 levels and activity decrease when MDM2 returns to a more stable state later in the stress response. The destabilization of MDM2 is required for p53 activation, as blocking MDM2 degradation via proteasome inhibition prevents p53 transactivation in DNA-damaged cells by enabling MDM2 to bind and inhibit p53. MDM2 destabilization is controlled by DNA damage-activated post-translational modifications and by its own RING domain, implying a possible role for the RING domain-interacting protein, MDMX, in regulating MDM2 stability. We propose that accelerated degradation of MDM2 limits its binding to p53 during a stress response and enables p53 to accumulate and remain active, even as p53 transcriptionally activates more MDM2. Thus, the induction of MDM2 RNA by activated p53 may create a reserve of MDM2 that can inactivate p53 once the DNA damage stimulus has abated and MDM2 is restabilized. As many tumors inactivate wild type p53 through MDM2 overexpression, exploiting the pathways that trigger MDM2 auto-degradation may be an important new strategy for chemotherapeutic intervention.
Direct observation of a ternary complex between the dimeric enzyme HIV-1 protease and a substrate-based inhibitor (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect observation of a ternary complex between the dimeric enzyme HIV-1 protease and a substrate-based inhibitorManuel Baca and Stephen B. H. KentCite this: J. Am. Chem. Soc. 1992, 114, 10, 3992–3993Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ja00036a066https://doi.org/10.1021/ja00036a066research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Macrophage fusion (2005)

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell-specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed.
Tumor marker studies of cervical smears: an immunohistochemical approach. (1994)

Immunoreactivity with monoclonal antibodies against epithelial membrane antigen (EMA), vimentin, squamous epithelium-specific keratin, nonsquamous epithelium-specific keratin, and polyclonal antibodies epithelial cells of 55 cervical smears using the avidin-biotin-peroxidase complex and indirect immunoperoxidase methods to detect antigens. Most of the abnormal squamous cells with few normal cells were reactive for EMA but the intensity of the reaction was variable in both cases. There was no correlation in the reactivity between normal and abnormal cells with different cytokeratins varying in their molecular weight. Vimentin was also reactive with both cells. The results of this experiment suggest that antibodies used, appear to be of limited usefulness in the diagnosis of cervical smears.
Artemisia annua L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin (2006)

Artemisinin, a sesquiterpene lactone endoperoxide derived from the plant Artemisia annua, forms the basis of the most important treatments of malaria in use today. In an effort to elucidate the biosynthesis of artemisinin, an expressed sequence tag approach to identifying the relevant biosynthetic genes was undertaken using isolated glandular trichomes as a source of mRNA. A cDNA clone encoding a cytochrome P450 designated CYP71AV1 was characterized by expression in Saccharomyces cerevisiae and shown to catalyze the oxidation of the proposed biosynthetic intermediates amorpha-4,11-diene, artemisinic alcohol and artemisinic aldehyde. The identification of the CYP71AV1 gene should allow for the engineering of semi-synthetic production of artemisinin in appropriate plant or microbial hosts.
Diabetes and the enteric nervous system (2007)

Diabetes is associated with several changes in gastrointestinal (GI) motility and associated symptoms such as nausea, bloating, abdominal pain, diarrhoea and constipation. The pathogenesis of altered GI functions in diabetes is multifactorial and the role of the enteric nervous system (ENS) in this respect has gained significant importance. In this review, we summarize the research carried out on diabetes-related changes in the ENS. Changes in the inhibitory and excitatory enteric neurons are described highlighting the role of loss of inhibitory neurons in early diabetic enteric neuropathy. The functional consequences of these neuronal changes result in altered gastric emptying, diarrhoea or constipation. Diabetes can also affect GI motility through changes in intestinal smooth muscle or alterations in extrinsic neuronal control. Hyperglycaemia and oxidative stress play an important role in the pathophysiology of these ENS changes. Antioxidants to prevent or treat diabetic GI motility problems have therapeutic potential. Recent research on the nerve-immune interactions demonstrates inflammation-associated neurodegeneration which can lead to motility related problems in diabetes.
Design study on a direct conversion receiver front-end for 280 MHz, 900 MHz, and 2.6 GHz band radio communication systems (2002)

The authors describe the required RF stage performance for a direct conversion receiver for 280 MHz, 900 MHz, and 2.6 GHz system applications. The required attenuation level for LO (local-oscillator) leakage for the assumed system terminal is calculated. Furthermore, from test receiver measurements, it was found that LO circuit shielding is necessary for practical system applications. The required out-of-band attenuation level of an RF filter for interference signals was also investigated quantitatively from experimental data obtained from bit-error-rate measurements in an actual radio wave environment and from calculations based on a 1 dB gain compression point of the mixer. Thus, it has been found that an interference rejection filter is necessary for practical direct conversion receiver applications. However, the filter specification is largely relaxed compared with the image rejection filter in a conventional superheterodyne architecture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The rRNA operon from Zea mays chloroplasts: nucleotide sequence of 23S rDNA and its homology with E.coli 23S rDNA (1981)

The nucleotide sequence of 23S rDNA from Zea mays chloroplasts has been determined. Alignment with 23S rDNA from E.coli reveals 71 percent homology when maize 4.5S rDNA is included as an equivalent of the 3' end of E.coli 23S rDNA. Among the conserved sequences are sites for base modification. Chloramphenicol sensitivity and ribosomal subunit interaction. A proposal for the base pairs formed between 16S and 23S rRNAs during the 30S/50S subunit interaction is presented. The alignment of maize 23S rDNA with that of E.coli reveals three small insertion sequences of 25, 65 and 78 base pairs, whereas maize 16S rDNA shows only deletions when compared with the E.coli species.
Role of the Intracellular Domain of IL-7 Receptor in T Cell Development (2007)

Signals from the IL-7R are uniquely required for T cell development and maintenance, despite the resemblance of IL-7R to other cytokine receptors and the apparent sharing of common signaling pathways. This unique requirement could either reflect unique expression of IL-7R or IL-7, or it could indicate that the IL-7R delivers unique signals. To determine whether the IL-7R provided unique signals, we exchanged its intracellular domain with that of other cytokine receptors: IL-4R, IL-9R, and prolactin receptor (PRLR). Chimeric receptors were used to reconstitute development of IL-7R(-/-) hemopoietic progenitors by transducing the receptors in retroviral vectors. Whereas IL-7R(-/-) thymocytes are arrested at the double-negative stage, IL-4R, IL-9R, or PRLR all imparted some progression to the double-positive stage. IL-4R and PRLR gave only small numbers of thymocytes, whereas IL-9R gave robust alphabeta T cell development and reconstitution of peripheral CD4 and CD8 cells, indicating that it can duplicate many of the functions of IL-7R. However, IL-9R failed to reconstitute rearrangement of the TCRgamma locus or development of gammadelta T cells. Thus, the IL-7R signals required in the alphabeta T cell lineage (such as survival and proliferation) are not unique to this receptor, whereas rearrangement of the TCRgamma locus may require a signal that is not shared by other receptors.
Kingsley, K.V., Boone, R. (2008). Effects of multimedia software on achievement of middle school students in an American History class (2012)

Dit artikel doet verslag van een onderzoek naar studieprestaties bij het vak geschiedenis als gevolg van het gebruik van een interactief softwareprogramma dat is ontworpen om de leerlingen te laten leren door middel van digitale multimedia. In dit onderzoek wilden Kingsley en Boone meten of het gebruik van deze media de leerprestaties van leerlingen (positief) beinvloedt
Biological advances and clinical applications of Fc receptors for IgG. (1994)

There are three classes of Fc gamma receptor proteins, Fc gamma RI (CD64), Fc gamma RII (CDw32), and Fc gamma RIII (CD16), which are encoded by at least eight genes. In this review we summarize some of the biological advances in the Fc gamma receptors during the past year, specifically: 1) identification of genes and their products; 2) regulation of gene expression and modulation of receptor number; 3) cellular functions and mechanisms of signal transduction; 4) ligand binding and the role of polymorphisms; and 5) soluble Fc gamma receptors. We also highlight the direct clinical applications of this Fc gamma receptor research.
ZD4054, a potent endothelin receptor A antagonist, inhibits ovarian carcinoma cell proliferation. (2006)

Endothelin-1 (ET-1) is present at high concentrations in ovarian cancer ascites and is overexpressed in primary and metastatic ovarian carcinomas. In these tumors, the presence of ET-1 correlates with tumor grade, enhanced neovascularization, and with vascular endothelial growth factor (VEGF) expression. ET-1 acts as an autocrine factor selectively through ET(A) receptor (ET(A)R), predominantly expressed in ovarian carcinoma cells resulting in increased VEGF production and VEGF-mediated angiogenic effects. Previous results demonstrated that in ovarian carcinoma cells, activation of the ET-1/ET(A)R axis promotes cell proliferation, neovascularization, and invasion, which are the principal hallmarks of tumor progression. The present study was designed to investigate the in vitro effects of trans, trans-2(4-methoxydhenyl)-4-(1-3-benzodiazol-5-yl)-1-(dibutylaminocarbonylmethyl)-pyrrolidine-3-carboxylic acid (ZD4054), an orally active specific ET(A)R antagonist, on the ET-1-induced mitogenic effect in OVCA 433 and HEY ovarian carcinoma cell lines secreting ET-1 and expressing ET(A)R and ET(B)R mRNA. We show that ET(A)R blockade by ZD4054 inhibits ET-1-induced mitogenic effects, while the ET(B)R antagonist, BQ 788, is ineffective. In conclusion, our data demonstrate that ZD4054 is capable in inhibiting the proliferative activity of ET-1, indicating that this specific ET(A)R antagonist may be a potential candidate in developing novel treatment of ovarian carcinoma.
Miro: visual specification of security (1990)

Miro is a set of languages and tools that support the visual specification of file system security. Two visual languages are presented: the instance language, which allows specification of file system access, and the constraint language, which allows specification of security policies. Miro visual languages and tools are used to specify security configurations. A visual language is one whose entities are graphical, such as boxes and arrows, specifying means stating independently of any implementation the desired properties of a system. Security means file system protection: ensuring that files are protected from unauthorized access and granting privileges to some users, but not others. Tools implemented and examples of how these languages can be applied to real security specification problems are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Highly Luminescent CdSe/ZnSe Core/Shell Nanocrystals of Low Size Dispersion (2002)

A simple synthetic route for the preparation of high-quality CdSe/ZnSe core/shell nanocrystals without the use of any pyrophoric organometallic precursors is presented. Effective surface passivation of monodisperse CdSe nanocrystals is achieved by overcoating them with a ZnSe shell, applying zinc stearate as a zinc source. The resulting core/shell nanocrystals exhibit high room temperature photoluminescence efficiencies (60−85%) in organic solvents as well as in water after functionalization with mercaptoundecanoic acid (MUA).