gebhart/patrepeval huggingface dataset:
Audiovisual celebrity recognition in unconstrained web videos (2009)

The number of video clips available online is growing at a tremendous pace. Conventionally, user-supplied metadata text, such as the title of the video and a set of keywords, has been the only source of indexing information for user-uploaded videos. Automated extraction of video content for unconstrained and large scale video databases is a challenging and yet unsolved problem. In this paper, we present an audiovisual celebrity recognition system towards automatic tagging of unconstrained Web videos. Prior work on audiovisual person recognition relied on the fact that the person in the video is speaking and the features extracted from audio and visual domain are associated with each other throughout the video. However, this assumption is not valid on unconstrained Web videos. Proposed method finds the audiovisual mapping and hence improve upon the association assumption. Considering the scale of the application, all pieces of the system are trained automatically without any human supervision. We present the results on 26,000 videos and show the effectiveness of the method per-celebrity basis.
Gonadotrophin receptor hormone analogues in combination with add-back therapy: an update (2012)

Gonadotrophin receptor hormone analogues (GnRHa) have been used in a range of sex hormone-dependent disorders. In the management of premenstrual syndrome, they can completely abolish symptoms. The success of GnRHa in the treatment of endometriosis and adjuvant therapy in the management of fibroids is proven. This efficacy does not come without a cost and the side-effects of the hypo-estrogenic state have limited their application. The use of add-back therapy to counter these effects has enabled wider application, longer durations of treatment and an increase in compliance. This review article is an update on the evidence supporting gonadotrophin receptor hormone analogues in combination with add-back therapy.
Lower Extremity Exoskeletons and Active Orthoses: Challenges and State-of-the-Art (2008)

In the nearly six decades since researchers began to explore methods of creating them, exoskeletons have progressed from the stuff of science fiction to nearly commercialized products. While there are still many challenges associated with exoskeleton development that have yet to be perfected, the advances in the field have been enormous. In this paper, we review the history and discuss the state-of-the-art of lower limb exoskeletons and active orthoses. We provide a design overview of hardware, actuation, sensory, and control systems for most of the devices that have been described in the literature, and end with a discussion of the major advances that have been made and hurdles yet to be overcome.
Scavenger function of sinusoidal liver cells. Acetylated low-density lipoprotein is endocytosed via a route distinct from formaldehyde-treated serum albumin. (1985)

Chemically modified proteins such as acetylated low-density lipoprotein (acetyl-LDL) and formaldehyde-treated serum albumin (f-Alb) infused intravenously are known to undergo receptor-mediated endocytosis by sinusoidal liver cells, major intravascular scavenger cells in vivo. The aim of the present study was to elucidate whether the endocytic uptake of acetyl-LDL and f-Alb is mediated by the same receptor or not. Experiments on the binding of 125I-acetyl-LDL to isolated rat liver sinusoidal cells revealed the presence of a specific, high-affinity, saturable, membrane-associated receptor with an apparent Kd = 7 micrograms of the ligand at 0 degrees C. Unlabeled acetyl-LDL effectively inhibited 125I-f-Alb binding to the cells. By contrast, the binding of 125I-acetyl-LDL to the cells was affected neither by unlabeled f-Alb nor by the antibody raised against the f-Alb receptor. These results indicate that the scavenger receptors for these two ligands are distinct from each other but similarly sensitive to polyanionic compounds.
The RpoS Sigma factor relieves H‐NS‐mediated transcriptional repression of csgA, the subunit gene of fibronectin‐binding curli in Escherichia coli (1993)

Curli encoded by the curlin subunit gene, csgA, are fibronectin- and laminin-binding fibres expressed by many natural Escherichia coli and E. coli K-12 strains in response to low temperature, low osmolarity and stationary-phase growth conditions. Curli expression is dependent on RpoS, a sigma factor that controls many stationary phase-inducible genes. Many commonly used K-12 strains carry an amber mutation in rpoS. Strains able to form curli carry an amber suppressor whereas curli-negative E. coli K-12 strains, in general, are sup0. Introduction of SupD, SupE, or supF suppressors into sup0 strains resulted in expression of temperature-regulated curli. In curli-deficient, RpoS- E. coli K-12 strains, csgA is transcriptionally activated by mutations in hns, which encodes the histone-like protein H-NS. Curli expression, fibronectin binding, and csgA transcription remain temperature- and osmoregulated in such double mutants. Our data suggest that RpoS+ strains, and hence curli-proficient strains of E. coli K-12, are relieved for the transcriptional repression mediated by the H-NS protein upon accumulating RpoS as cells reach stationary phase.
Monomethylfumarate affects polarization of monocyte‐derived dendritic cells resulting in down‐regulated Th1 lymphocyte responses (2004)

Psoriasis vulgaris, a type-1 cytokine-mediated chronic skin disease, can be treated successfully with fumaric acid esters (FAE). Beneficial effects of this medication coincided with decreased production of IFN-gamma. Since dendritic cells (DC) regulate the differentiation of T helper (Th) cells, this study focussed on effects of monomethylfumarate (MMF, bioactive metabolite of FAE) on polarization of monocyte-derived DC. MMF-incubated, lipo-polysaccharide-stimulated DC (MMF-DC) produced dramatically (p<0.05) reduced levels of IL-12p70 and IL-10 (8+/-4% and 20+/-4%, respectively) compared to control DC. MMF-DC were mature. MMF affected polarization of DC irrespective of polarization factor(s) and ligands for the various Toll-like receptors used. Coculture of MMF-DC with naive and primed allogenous Th cells resulted in lymphocytes producing less IFN-gamma, i.e. 59% and 54% of that by the respective Th cells cocultured with control DC. IL-4 production by primed, but not naive Th cells cocultured with MMF-DC was decreased as compared to cocultures with control DC. IL-10 production by naive and primed Th cells cocultured with MMF-DC and control DC did not differ. In addition, MMF inhibited LPS-induced NF-kappaB activation in DC. Together, beneficial effects of FAE in psoriasis involve modulation of DC polarization by MMF such that these cells down-regulate IFN-gamma production by Th cells.
DIRA: Automatic Detection, Identification and Repair of Control-Hijacking Attacks. (2005)

Buffer overflow attacks are known to be the most com-mon type of attacks that allow attackers to hijack a re-mote system by sending a specially crafted packet to a vulnerable network application running on it. A compre-hensive defense strategy against such attacks should in-clude (1) an attack detection component that determines the fact that a program is compromised and prevents the attack from further propagation, (2) an attack identifica-tion component that identifies attack packets so that one can block such packets in the future, and (3) an attack repair component that restores the compromised applica-tion’s state to that before the attack and allows it to con-tinue running normally. Over the last decade, a significant amount of research has been vested in the systems that can detect buffer overflow attacks either statically at com-pile time or dynamically at run time. However, not much effort is spent on automated attack packet identification or attack repair. In this paper we present a unified solu-tion to the three problems mentioned above. We imple-mented this solution as a GCC compiler extension called DIRA that transforms a program’s source code so that the resulting program can automatically detect any buffer overflow attack against it, repair the memory damage left by the attack, and identify the actual attack packet(s). We used DIRA to compile several network applications with known vulnerabilities and tested DIRA’s effectiveness by attacking the transformed programs with publicly avail-able exploit code. The DIRA-compiled programs were always able to detect the attacks, identify the attack pack-ets and most often repair themselves to continue normal execution. The average run-time performance overhead for attack detection and attack repair/identification is 4% and 25 % respectively. 1.
Current pathophysiological views on vibration-induced Raynaud's phenomenon (2003)

This review attempts to summarize and discuss contemporary pathogenetic views on vibration-induced Raynaud's phenomenon assuming its multifactorial etiology. An increase in central and peripheral sympathetic nervous activity is discussed based on different physiological indicators of autonomic dysfunction and sympathetic hyperactivity. Local acral vasodysregulation is considered. Receptor and nerve endings dysfunction presented with predominance of alpha(2)-receptor function in the digital arteries and neuronal loss in those digital cutaneous perivascular nerves containing calcitonin gene-related peptide result in deficiency of endogenous release of this powerful vasodilator. Endothelial damage and dysregulation induced by vibration and increased shear stresses are demonstrated by the elevated plasma level of thrombomodulin and of von Willebrand factor and reduced endothelium-dependent vasodilator responses. The concentrations of endothelin-1 are high, the highest being in most advanced stages. Decreased plasma thiol level, indicating increased production and activity of free radicals, contribute to vasospastic paroxysms in vibration white finger patients. Dysbalance of local vasoactive factors with opposing effects on vascular smooth muscle like endothelin and nitric oxide, endothelin and calcitonin gene-related peptide, nitric oxide and superoxide anion are discussed. Disturbed smooth muscle response is supposed. Changes in hemostasis, fibrinolysis and hemorrheology, activation of blood cells with erythrocyte hyperaggregation and red cell hypodeformability, platelet aggregation with increased release of vasoconstricting thromboxane A(2) and serotonin as well as leukocyte activation, entrapment within capillaries and post-capillary venules and increased reactive oxygen species and lysosomal lytic enzymes release might also contribute to digital vasospasms and tissue damage. Elevated soluble intercellular adhesion molecule-1 levels involved in the adherence of leukocytes to endothelium and to other leukocytes have been found in patients with hand-arm vibration syndrome.
Autolocker (2006)

The movement to multi-core processors increases the need for simpler, more robust parallel programming models. Atomic sections have been widely recognized for their ease of use. They are simpler and safer to use than manual locking and they increase modularity. But existing proposals have several practical problems, including high overhead and poor interaction with I/O. We present pessimistic atomic sections, a fresh approach that retains many of the advantages of optimistic atomic sections as seen in "transactional memory" without sacrificing performance or compatibility. Pessimistic atomic sections employ the locking mechanisms familiar to programmers while relieving them of most burdens of lock-based programming, including deadlocks. Significantly, pessimistic atomic sections separate correctness from performance: they allow programmers to extract more parallelism via finer-grained locking without fear of introducing bugs. We believe this property is crucial for exploiting multi-core processor designs.We describe a tool, Autolocker, that automatically converts pessimistic atomic sections into standard lock-based code. Autolocker relies extensively on program analysis to determine a correct locking policy free of deadlocks and race conditions. We evaluate the expressiveness of Autolocker by modifying a 50,000 line high-performance web server to use atomic sections while retaining the original locking policy. We analyze Autolocker's performance using microbenchmarks, where Autolocker outperforms software transactional memory by more than a factor of 3.
The neural basis of the blood–oxygen–level–dependent functional magnetic resonance imaging signal (2002)

Magnetic resonance imaging (MRI) has rapidly become an important tool in clinical medicine and biological research. Its functional variant (functional magnetic resonance imaging; fMRI) is currently the most widely used method for brain mapping and studying the neural basis of human cognition. While the method is widespread, there is insufficient knowledge of the physiological basis of the fMRI signal to interpret the data confidently with respect to neural activity. This paper reviews the basic principles of MRI and fMRI, and subsequently discusses in some detail the relationship between the blood-oxygen-level-dependent (BOLD) fMRI signal and the neural activity elicited during sensory stimulation. To examine this relationship, we conducted the first simultaneous intracortical recordings of neural signals and BOLD responses. Depending on the temporal characteristics of the stimulus, a moderate to strong correlation was found between the neural activity measured with microelectrodes and the BOLD signal averaged over a small area around the microelectrode tips. However, the BOLD signal had significantly higher variability than the neural activity, indicating that human fMRI combined with traditional statistical methods underestimates the reliability of the neuronal activity. To understand the relative contribution of several types of neuronal signals to the haemodynamic response, we compared local field potentials (LFPs), single- and multi-unit activity (MUA) with high spatio-temporal fMRI responses recorded simultaneously in monkey visual cortex. At recording sites characterized by transient responses, only the LFP signal was significantly correlated with the haemodynamic response. Furthermore, the LFPs had the largest magnitude signal and linear systems analysis showed that the LFPs were better than the MUAs at predicting the fMRI responses. These findings, together with an analysis of the neural signals, indicate that the BOLD signal primarily measures the input and processing of neuronal information within a region and not the output signal transmitted to other brain regions.
Efficient processing of joins on set-valued attributes (2003)

Object-oriented and object-relational DBMS support set valued attributes, which are a natural and concise way to model complex information. However, there has been limited research to-date on the evaluation of query operators that apply on sets. In this paper we study the join of two relations on their set-valued attributes. Various join types are considered, namely the set containment, set equality, and set overlap joins. We show that the inverted file, a powerful index for selection queries, can also facilitate the efficient evaluation of most join predicates. We propose join algorithms that utilize inverted files and compare them with signature-based methods for several set-comparison predicates.
Synthesis of Ordered, Uniform, Macroporous Carbons with Mesoporous Walls Templated by Aggregates of Polystyrene Spheres and Silica Particles for Use as Catalyst Supports in Direct Methanol Fuel Cells (2004)

Porous carbons with mesoporous walls (see Figure) are produced by template replication of aggregates of small silica particles, which were themselves templated by a self-assembled lattice of larger monodisperse polystyrene spheres. A direct methanol fuel cell using the new material as a catalyst support shows significantly improved performance due to the combination of high surface area and facile fuel and product diffusion.
Design of k‐space channel combination kernels and integration with parallel imaging (2013)

The proposed method enables high quality channel combination to occur earlier in the reconstruction pipeline, reducing computational and memory requirements for image reconstruction.
Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. (1986)

Selective inhibition of regulatory immediate early (IE) genes of herpes simplex virus type 1 (HSV-1) should inhibit virus growth. Treatment of HSV-1-infected cells with the oligo(nucleoside methylphosphonate) d(TpCCTCCTG) (deoxynucleoside methylphosphonate residues in italic), which is complementary to the acceptor splice junction of HSV-1 IE pre-mRNA 4 and 5, before (1-24 hr) or at the time of infection caused a dose-dependent inhibition in virus replication. Virus titers were decreased 50% and 90% in cells treated with 25 microM and 75 microM oligomer, respectively; at 300 microM, a 99% reduction in virus production was observed. Viral DNA synthesis was reduced 70-75% and there was a 90% reduction in synthesis of viral proteins, including other IE species and viral functional (130-kDa major DNA-binding) and structural (glycoprotein gB) proteins. In the same concentration range, d(TpCCTCCTG) caused a minimal reduction (0-30%) in protein synthesis and growth rates (less than 40%) of uninfected cells. The data suggest that oligo(nucleoside methylphosphonate)s may be effective in antiviral chemotherapy.
The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain (1989)

We monitor cellular responses to a penetrating wound in the cerebral cortex of adult rat during the first weeks after injury. Two classes of activated mononuclear phagocytes containing acetylated low-density lipoprotein (ac-LDL) receptors appear within hours at the wound site. One type of cell surrounding the lesion edge had thin, delicate processes and is identical in appearance to ramified microglia found in developing brain. Within the lesion, round cells are recognized as blood-borne macrophages when labeled by intravenous injection of carbon particles. Thus, both process-bearing reactive microglia and invading macrophages respond to brain trauma. The greatest number of ac-LDL(+) or nonspecific esterase(+) mononuclear phagocytes appears 2 days after injury within the wound site and are associated with a peak production of the cytokine interleukin-1 (IL-1). Because intracerebral infusion of IL-1 is known to stimulate astrogliosis and neovascularization (Giulian et al., 1988), we examine the time course of injury-induced reactive astrogliosis and angiogenesis. A 5-fold increase in the number of reactive astroglia is found at 3 d and a marked neovascularization at 5 d after injury. During the first week, mononuclear phagocytes engulf particles and clear them from the wound site either by migrating to the brain surface or by entering newly formed brain vasculature. To investigate further the role of reactive brain mononuclear phagocytes in CNS injury, we use drugs to inhibit trauma-induced inflammation. When applied in vivo, chloroquine or colchicine reduce the number of mononuclear phagocytes in damaged brain, help to block reactive astrogliosis and neovascularization, and slow the rate of debris clearance from sites of traumatic injury. In contrast, the glucocorticoid dexamethasone neither reduces the number of brain inflammatory cells nor hampers such responses as phagocytosis, astrogliosis, neovascularization, or debris clearance in vivo. Our observations show that mononuclear phagocytes play a major role in wound healing after CNS trauma with some events controlled by secretion of cytokines. Moreover, certain classes of immunosuppressive drugs may be useful in the treatment of acute brain injury.
Regulatory Characteristics of the Diphosphopyridine Nucleotide-specific Malic Enzyme of Escherichia coli (1970)

Abstract The DPN+-specific malic enzyme (EC 1.1.1.40), which catalyzes the reductive carboxylation of pyruvate with concomitant oxidation of DPNH, has been purified from glucose-grown cells of Escherichia coli. The enzyme is inhibited by ATP (and some other nucleoside triphosphates) and coenzyme A in an allosteric manner. Both of the inhibitors cause noncompetitive inhibition when DPN+ or malate is the varied substrate. In addition, the hyperbolic rate-concentration plots for malate in the absence of the inhibitors become sigmoidal in their presence. Aspartate acts as an activator for the enzyme and in its presence the inhibition caused by CoA is reversed, while the degree of inhibition caused by ATP remains unchanged. From these experiments it is deduced that the inhibitory binding sites for CoA and ATP are different from each other. Since quite low levels of CoA are effective in inhibiting the enzyme it is suggested that the enzyme does not function in vivo unless specific deinhibition is brought about by excess aspartate.
Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. (1992)

Serum triglyceride concentration has prognostic value, both for assessing coronary heart disease risk and in predicting the effect of gemfibrozil treatment, especially when used in combination with HDL-C and LDL-C.
Cellular Effects and Antitumor Activity of RET Inhibitor RPI-1 on MEN2A-Associated Medullary Thyroid Carcinoma (2004)

Ret oncoproteins represent exploitable targets for therapeutic intervention in MEN2A-associated medullary thyroid carcinoma. The antitumor efficacy and oral bioavailability of RPI-1 support its therapeutic potential.
Duplex stainless steels for osteosynthesis devices (1989)

The austenitic stainless steels used today for the manufacture of osteosynthesis devices are sensitive to crevice corrosion. In this study the corrosion properties of some duplex stainless steels were evaluated and compared to traditional austenitic stainless steels. According to our results the following ranking was established: 23Cr-4Ni less than AISI 316L less than ASTM F138 less than 22Cr-5Ni-3Mo less than 27Cr-31Ni-3.5Mo less than 25Cr-7Ni-4Mo-N. In particular the results showed that the high-performance 25Cr-7Ni-4Mo-N duplex stainless steel, with high molybdenum and nitrogen contents, can be considered not susceptible to crevice corrosion in the human body. The duplex stainless steels have also better mechanical properties at the same degree of cold working compared with austenitic stainless steels. Hence the 25Cr-7Ni-4Mo-N duplex stainless steel can be considered a convenient substitute of ASTM F138 for orthopedic and osteosynthesis devices.
Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein (2020)

Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Here, we mined the memory B cell repertoire of a convalescent SARS donor and identified 200 SARS-CoV-2 binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of pre-existing memory B cells (MBCs) elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a new target for the rational design of pan-sarbecovirus vaccines.