gebhart/patrepeval huggingface dataset:
Use of an on-column fracture in capillary zone electrophoresis for sample introduction (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of an on-column fracture in capillary zone electrophoresis for sample introductionMichael C. Linhares and Peter T. KissingerCite this: Anal. Chem. 1991, 63, 18, 2076–2078Publication Date (Print):September 15, 1991Publication History Published online1 May 2002Published inissue 15 September 1991https://pubs.acs.org/doi/10.1021/ac00018a035https://doi.org/10.1021/ac00018a035research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography (2000)

PET improves the rate of detection of local and distant metastases in patients with non-small-cell lung cancer.
[A new medical treatment for thrombosis by genetic engineering]. (1999)

There has been established a new medical treatment that is due to the progress of genetic engineering and the development of gene delivery techniques. As well as other fields, cardiologists investigate a protocol for gene therapy, including thrombosis and its related diseases. They make steady progress in the application of clinical trials. Specially, they have focused on gene therapy for the restenosis after percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass grafting (CABG), and there are many successful reports. As one of the strategy for an inhibition of thrombosis formation, they try to deliver the genes of cyclooxygenase-1, tissue plasminogen activator (tPA) and endothelial nitric oxide synthetase (eNOS). Also, we target for the introduction of anti-sense oligonucleotide; proliferating cell nuclear antigen (PCNA), cell division cycle (cdc)-2 kinase, or p21 (sdi-1) gene in order to inhibit the progression of cell cycle in which vascular smooth muscle cells (VSMCs). Others and we pay attention to the function of vessel protection and find a protocol for the gene delivery of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), which selectively induce the growth of endothelial cell. Since, particularly, VEGF and HGF induce angiogenesis, Others and we try to cure arteriosclerosis obliterans (ASO) with delivering these genes to the affected part. In addition, we develop new techniques such as the delivery of NF kappa B gene toward myocardial infarction and the transplantation of genetically modified myocardium that is treated with gene therapy. We place our hopes on these new technical applications to the clinical trial.
Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family (1999)

We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuroblastoma cells. NNT-1/BSF-3 shows activities typical of IL-6 family members. In vitro, it supports the survival of chicken embryo motor and sympathetic neurons. In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase. NNT-1/BSF-3 is a gp130 activator with B-cell stimulating capability.
<title>Performance properties of near-monodisperse novolak resins</title> (1995)

Novolak resins are the most complex and important polymers used in photoresists for microlithography. We have developed methods for fractionation of novolak resins based on supercritical fluid technology to afford polymers with molecular weights distributions (M<SUB>W</SUB>/M<SUB>N</SUB>) approaching 1.0. Properties (glass transition, dissolution, and lithographic) of monodisperse novolak resins demonstrate extremely exaggerated molecular weight effects. I- line resists formulated from these ultra-fractionated resins show extraordinarily diverse lithographic properties, ranging from low-to-high contrast, the absence or presence of microgrooving and residue, and photospeed and thermal properties that are highly controllable. Ultimately, a prototype resist formulation based on mixtures of fractions combining high resolution (0.35 microns) and fast photospeed (125 mJ/cm<SUP>2</SUP>) was demonstrated. New rules for the influence of novolak molecular weight on photoresist performance are presented.
A Review of the Methods for Human iPSC Derivation (2013)

The ability to reprogram somatic cells to induced pluripotent stem cells (iPSCs) offers an opportunity to generate pluripotent patient-specific cell lines that can help model human diseases. These iPSC lines could also be powerful tools for drug discovery and the development of cellular transplantation therapies. Many methods exist for generating iPSC lines but those best suited for use in studying human diseases and developing therapies must be of adequate efficiency to produce iPSCs from samples that may be of limited abundance, capable of reprogramming cells from both skin fibroblasts and blood, and footprint-free. Several reprogramming techniques meet these criteria and can be utilized to derive iPSCs in projects with both basic scientific and therapeutic goals. Combining these reprogramming methods with small molecule modulators of signaling pathways can lead to successful generation of iPSCs from even the most recalcitrant patient-derived somatic cells.
Phylogenetic and epidemiological analysis ofNeisseria meningitidisusing DNA probes (1992)

The genetic relationships between various serotypes and serogroups of meningococcal strains were investigated by restriction fragment-length polymorphism (RFLP) analysis using a number of random DNA probes and a probe containing a truncated copy of the meningococcal insertion sequence IS1106. The data were used to estimate genetic distance between all pairs of strains and to construct phylogenetic trees for meningococcal strains. B15:P1.16R strains isolated from cases of systemic meningococcal disease in two health districts with a high incidence of disease were clonal in contrast to similar strains from cases occurring in other parts of the UK. Strains from these areas, which contain a similar genomic deletion, were found to be derived from two distinct lineages within the B15:P1.16R phylogenetic group. RFLP data demonstrated that present serological typing systems for the meningococcus do not necessarily reflect true genetic relationships.
Anti-Inflammatory Drug Discovery (2012)

Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medicinal chemistry literature for each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections key targets covered will include the AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2; Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK , Bruton's Tyrosine Kinase; GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists; Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 and a final miscellaneous section that looks at Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia.
Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin (1973)

Epidermal growth factor (EGF) stimulates both DNA and RNA synthesis in contact-inhibited human fibroblasts. Stimulation of DNA synthesis is observed at concentrations as low as 3 pM, is half-maximal at 70 pM, and is maximal at 300 pM EGF. The action of EGF is similar to that of fetal-calf serum, but is distinguished by the time-course of stimulation and by the ability of serum to stimulate further those cells maximally stimulated by EGF. Cells that synthesize DNA in response to physiological concentrations of EGF (10(-11) to 10(-10) M) are insensitive to physiological concentrations of insulin (10(-11) to 10(-10) M) and respond only minimally to very high concentrations of this hormone (10(-6) M). The biological activity of EGF is paralleled by binding of this peptide to fibroblasts in a specific and saturable manner; the dissociation constant is about 800 pM. The binding of EGF is unaffected by either insulin or cholera toxin. Cholera toxin inhibits the action of both EGF and serum. Suppression of DNA synthesis is observed at 0.02 pM toxin, and is maximal at about 2 pM. Cells treated with cholera toxin at these concentrations appear to be otherwise viable by several criteria. The stimulatory effects of EGF are also inhibited by theophylline and dibutyryl cyclic AMP separately or in combination. These observations indicate that fibroblasts possess receptors for EGF by biological and physicochemical criteria, and suggest that a similar if not identical peptide may be amongst those factors in sera which stimulate cell growth. The possibility is considered that EGF and cholera toxin modulate the ability of a cell to initiate polynucleotide synthesis by way of specific cell-surface interactions which in turn alter the levels of intracellular cyclic AMP.
A High‐Performance Polymer Tin Sulfur Lithium Ion Battery (2010)

Above and beyond: A tin sulfur lithium ion battery has an energy density value of the order of 1000 W h kg-1, which is five times higher than those of conventional batteries that containing intercalated materials (see picture). Replacement of the conventional liquid electrolyte with a polymer membrane brings improvements in the fabrication and safety of the battery.
Autism: Functional brain mapping of exceptional calendar capacity (2005)

The cerebral circuit involved in this man's prodigious calendar skill is similar to that normally involved in memory retrieval tasks. These results suggest that the prodigious capacities may be sustained by memory processing.
Image Registration-Based Bolt Loosening Detection of Steel Joints (2018)

Self-loosening of bolts caused by repetitive loads and vibrations is one of the common defects that can weaken the structural integrity of bolted steel joints in civil structures. Many existing approaches for detecting loosening bolts are based on physical sensors and, hence, require extensive sensor deployment, which limit their abilities to cost-effectively detect loosened bolts in a large number of steel joints. Recently, computer vision-based structural health monitoring (SHM) technologies have demonstrated great potential for damage detection due to the benefits of being low cost, easy to deploy, and contactless. In this study, we propose a vision-based non-contact bolt loosening detection method that uses a consumer-grade digital camera. Two images of the monitored steel joint are first collected during different inspection periods and then aligned through two image registration processes. If the bolt experiences rotation between inspections, it will introduce differential features in the registration errors, serving as a good indicator for bolt loosening detection. The performance and robustness of this approach have been validated through a series of experimental investigations using three laboratory setups including a gusset plate on a cross frame, a column flange, and a girder web. The bolt loosening detection results are presented for easy interpretation such that informed decisions can be made about the detected loosened bolts.
Effects of propranolol on myocardial oxygen consumption, substrate extraction, and haemodynamics in hypertrophic obstructive cardiomyopathy. (1980)

Myocardial substrate extraction, coronary sinus flow, cardiac output, and left ventricular pressure were measured at increasing pacing rates before and after propranolol (0.2 mg/kg) in 13 patients with hypertrophic obstructive cardiomyopathy (HOCM) during diagnostic cardiac catheterisation. At the lowest pacing rate myocardial oxygen consumption varied considerably between patients and very high values were found in several individuals (range 10.1 to 57.5 ml/min). These large differences between patients were not explicable by differences in cardiac work; consequently, cardiac efficiency, estimated from the oxygen cost of external work, varied between patients and was lower than normal in all but two. The pattern of substrate extraction at the lowest pacing rate was similar to results reported for the normal heart, and measured oxygen consumption could be accounted for by complete oxidation of the substrates extracted; thus there was no evidence of a gross abnormality of oxidative metabolism, suggesting that low efficiency lay in the utilisation rather than in the production of energy. Each of the four patients with the highest myocardial oxygen consumption and lowest values of efficiency sustained progressive reductions in lactate and pyruvate extraction as heart rate increased, and at the highest pacing rate had low (&lt; 3%) or negative lactate extraction ratios. In three of these four, coronary sinus flow did not increase progressively with each increment in heart rate. One patient with low oxygen consumption and normal efficiency also failed to increase coronary flow with the final increment in heart rate, and produced lactate at the highest pacing rate. Thus the five patients in whom pacing provoked biochemical evidence of ischaemia all had excessive myocardial oxygen demand and/or limited capacity to increase coronary flow. Propranolol did not change lactate extraction significantly at any pacing rate in either the ischaemic or non-ischaemic groups. In only one patient was ischaemia at the highest pacing rate abolished after propranolol, and this was associated with a 30 per cent reduction in oxygen consumption. These results do not demonstrate a direct effect of propranolol upon myocardial metabolism in patients with HOCM, but emphasise the potential value of beta-blockade in protecting these patients from excessive increases in heart rate.
mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils (2002)

Nonstandard abbreviations used: chronic granulomatous disease (CGD); polymorphonuclear neutrophils (PMNs); diethylpyrocarbonate (DEPC); open reading frames (ORFs); HEPES-supplemented HBSS (HHBSS); kanamycin resistance determinant (kan R ); ATP-binding cassette (ABC).
Multiresolutional texture analysis based on morphological techniques (1993)

The authors show the power of mathematical morphology as a tool for analysis of grey-level images, and especially texture. Textures are investigated by extracting a local fractal signature for a range of scales. The variation with changing resolution then characterizes the texture. Some results of a practical application of this technique to a brushed leather surface, are presented. >
<title>Experiences with semiautomatic aerotriangulation on digital photogrammetric stations</title> (1995)

With the development of higher-resolution scanners, faster image-handling capabilities, and higher-resolution screens, digital photogrammetric workstations promise to rival conventional analytical plotters in functionality, i.e. in the degree of automation in data capture and processing, and in accuracy. The availability of high quality digital image data and inexpensive high capacity fast mass storage offers the capability to perform accurate semi- automatic or automatic triangulation of digital aerial photo blocks on digital photogrammetric workstations instead of analytical plotters. In this paper, we present our investigations and results on two photogrammetric triangulation blocks, the OEEPE (European Organisation for Experimental Photogrammetric Research) test block (scale 1;4'000) and a Swiss test block (scale 1:12'000) using digitized images. Twenty-eight images of the OEEPE test block were scanned on the Zeiss/Intergraph PS1 and the digital images were delivered with a resolution of 15 micrometer and 30 micrometer, while 20 images of the Swiss test block were scanned on the Desktop Publishing Scanner Agfa Horizon with a resolution of 42 micrometer and on the PS1 with 15 micrometer. Measurements in the digital images were performed on the commercial Digital photogrammetric Station Leica/Helava DPW770 and with basic hard- and software components of the Digital Photogrammetric Station DIPS II, an experimental system of the Institute of Geodesy and Photogrammetry, ETH Zurich. As a reference, the analog images of both photogrammetric test blocks were measured at analytical plotters. On DIPS II measurements of fiducial marks, signalized and natural tie points were performed by least squares template and image matching, while on DPW770 all points were measured by the cross correlation technique. The observations were adjusted in a self-calibrating bundle adjustment. The comparisons between these results and the experiences with the functionality of the commercial and the experimental system are presented.
Computer System Intrusion Detection: A Survey (1999)

The ability to detect intruders in computer systems increases in importance as computers are increasingly integrated into the systems that we rely on for the correct functioning of society. This paper reviews the history of research in intrusion detection as performed in software in the context of operating systems for a single computer, a distributed system, or a network of computers. There are two basic approaches: anomaly detection and misuse detection. Both have been practiced since the 1980s. Both have naturally scaled to use in distributed systems and networks.
N1 neuraminidase of influenza virus A/FPV/Rostock/34 has haemadsorbing activity (1995)

The neuraminidase (NA) gene of influenza virus A/FPV/Rostock/34 virus (H7N1) was cloned and expressed in Sf9 cells using a baculovirus vector. The expression product had the expected molecular mass and showed neuraminidase activity. NA expressed in Sf9 cells also showed haemagglutinating activity as indicated by its ability to induce haemadsorption of chicken red blood cells. Haemadsorption depended on the presence of neuraminic acid on the erythrocytes, but was not blocked by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, a specific inhibitor of the enzymatic activity. These observations suggest that the N1 neuraminidase has two distinct reactive sites: a catalytic site and a receptor binding site. This concept was confirmed by site-directed mutagenesis which showed that the haemadsorbing activity of FPV NA was abolished when amino acids located on two surface loops at the putative binding site were exchanged. Substitutions on either of the two loops were sufficient for this effect. The mutated NAs retained full neuraminidase activity. In contrast, a mutated NA lacking neuraminidase activity still had haemadsorbing activity.
<title>Highly reliable oxide VCSELs manufactured at HP/Agilent Technologies</title> (2000)

We discuss the reliability of the oxide VCSELs made by Agilent Technologies (formerly part of Hewlett Packard). Measurements of operating temperature in fiber optic modules are given; these temperatures are higher than generally assumed. General challenges with oxide VCSEL reliability are introduced, and different types of failures are discussed. Long-term oxide VCSEL lifetest results are presented, along with observations about the thermal and current acceleration models. Production monitoring strategies are discussed, and the basic degradation phenomenology is briefly shown.
Effect of transtympanic low-pressure therapy in patients with unilateral Menière's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial (2012)

Use of the Meniett low-pressure generator improved patients' vertigo but not their hearing or vestibular function. This safe, minimally invasive treatment is recommended as second-line treatment for unilateral Menière's disease.
Product Analysis and Thermodynamic Simulations from the Pyrolysis of Several Biomass Feedstocks (2007)

The pyrolysis of southern pine, red oak, and sweet gum sawdust is reported. Pyrolysis experiments were conducted under either a helium or nitrogen atmosphere at ∼371−871 °C, to determine the balance between liquid and gas products. Gas- and liquid-phase pyrolysis products were identified using gas chromatography (GC) and GC/mass spectrometry (MS). A total of 109 liquid and 40 gas compounds were identified. A total of 59 chemical compounds (35 liquids and 24 gaseous products) were quantitatively determined. The influence of the gas-phase residence time and biomass feed particle size were studied. The gas residence time determined the extent of secondary reactions. Very short residence times enhanced liquid production versus gas production. Particle sizes (d < 105 μm, 105 μm < d < 149 μm, 149 μm < d < 297 μm, and d > 297 μm) did not have a pronounced effect on either the yield or product distributions, indicating that heat-transfer limitations within the particles were negligible. The pyrolysis of pine, red oak, and sweet gum sawdust yielded similar product distributions. Simulations were conducted using the ASPEN/SP software package based on Gibbs energy minimization. At high temperatures, dominant species were hydrogen and carbon monoxide, while at lower temperatures, methane, carbon dioxide, and water were the predominant species. Above 871 °C, further increases in the temperature did not affect the product distribution. Lower gasification temperatures and higher steam/carbon ratios resulted in higher hydrogen and carbon monoxide production.