gebhart/patrepeval huggingface dataset:
Kick Detection and Influx Size Estimation during Offshore Drilling Operations using Deep Learning (2019)

An uncontrolled or unobserved influx or kick during drilling has the potential to induce a well blowout, one of the most harmful incidences during drilling both in regards to economic and environmental cost. Since kicks during drilling are serious risks, it is important to improve kick and loss detection performance and capabilities and to develop automatic flux detection methodology. There are clear patterns during a influx incident. However, due to complex processes and sparse instrumentation it is difficult to predict the behaviour of kicks or losses based on sensor data combined with physical models alone. Emerging technologies within Deep Learning are however quite adapt at picking up on, and quantifying, subtle patterns in time series given enough data. In this paper, a new model is developed using Long Short-Term Memory (LSTM), a Recurrent Deep Neural Network, for kick detection and influx size estimation during drilling operations. The proposed detection methodology is based on simulated drilling dataand involves detecting and quantifying the influx of fluids between fractured formations and the well bore. The results show that the proposed methods are effective both to detect and estimate the influx size during drilling operations, so that corrective actions can be taken before any major problem occurs.
RPGRmutation analysis and disease: an update (2006)

Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene are the most common single cause of retinitis pigmentosa, accounting for up to 15 to 20% of cases in Caucasians. A total of 240 different RPGR mutations have been reported, including 24 novel ones in this work, which are associated with X-linked retinitis pigmentosa (XLRP) (95%), cone, cone-rod dystrophy, or atrophic macular atrophy (3%), and syndromal retinal dystrophies with ciliary dyskinesia and hearing loss (2%). All disease-causing mutations occur in one or more RPGR isoforms containing the carboxyl-terminal exon open reading frame 15 (ORF15), which are widely expressed but show their highest expression in the connecting cilia of rod and cone photoreceptors. Of reported RPGR mutations, 55% occur in a glutamic acid-rich domain within exon ORF15, which accounts for only 31% of the protein. RPGR forms complexes with a variety of other proteins and appears to have a role in microtubular organization and transport between photoreceptor inner and outer segments.
Structural studies of a hornet venom allergen antigen 5, Dol m V and its sequence similarity with other proteins. (1990)

The primary structures and the disulfide-bond pairings of two chromatographic forms A and B of a venom protein from white-faced hornet (Dolichovespula maculata) were determined. This protein, designated as antigen 5 (Dol m V), has 204-205 amino acid residues and it contains 4 disulfide bonds. This protein is an allergen in man but its biologic function in hornet is not yet known. Dol m V is found to have partial sequence similarity with pathogenesis-related proteins from tobacco and tomato leaves and with a sperm-coating protein from rat epididymis.
Genetics of Forage Attributes in Sorghum (2007)

The present investigation was carried out in order to study combining ability for forage attributes in sorghum. The experimental material included thirty-six genotypes including 8 parents and their twenty-right crosses generated in diallel fashion (without reciprocals). Analysis of variance for combining ability revealed that mean square due to GCA and SCA were significant for all the traits in all the environments. Various parents/crosses having good combining ability have been identified for dry fodder, green fodder and grain yield.
A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation. (1988)

Prior studies have shown that thymocytes, unlike peripheral T cells, do not proliferate in response to mitogenic combinations of anti-CD2 mAbs. The present study demonstrated that stimulation by a mitogenic anti-CD2 combination (9-1 plus 9.6) with anti-CD28 induced vigorous thymocyte proliferation in the absence of exogenous IL-2. This thymocyte proliferation was IL-2 dependent as shown by the complete inhibition using anti-IL-2-R mAbs. Induction of IL-2-R transcripts was detected in thymocytes stimulated by the anti-CD2 antibody combination alone or the anti-CD2 combination plus anti-CD28 antibody. However, induction of IL-2 transcripts was observed only in thymocytes triggered jointly by the anti-CD2 combination plus anti-CD28 antibodies. The double-negative (CD4-8-) or CD1+ thymocytes isolated by sorting or by panning were unresponsive to CD2/CD28 triggering. The same mitogenic signal could induce vigorous proliferation of thymocytes with a mature phenotype, i.e., CD3+CD4+ or CD3+CD8+ thymocytes. Immunofluorescence studies demonstrated that the majority of CD3+ thymocytes were CD28+, and most of the CD28+ cells were located in the medullary compartment of thymus. These results indicated that the T cell lineage surface molecules CD28 and CD2 are involved in the regulation of expansion and further differentiation of mature thymocytes.
Stress-induced expression of the Escherichia coli phage shock protein operon is dependent on sigma 54 and modulated by positive and negative feedback mechanisms. (1991)

The phage shock protein (psp) operon of Escherichia coli is strongly induced in response to heat, ethanol, osmotic shock, and infection by filamentous bacteriophages. The operon contains at least four genes--pspA, pspB, pspC, and pspE--and is regulated at the transcriptional level. We report here that psp expression is controlled by a network of positive and negative regulatory factors and that transcription in response to all inducing agents is directed by the sigma-factor sigma 54. Negative regulation is mediated by both PspA and the sigma 32-dependent heat shock proteins. The PspB and PspC proteins cooperatively activate expression, possibly by antagonizing the PspA-controlled repression. The strength of this activation is determined primarily by the concentration of PspC, whereas PspB enhances but is not absolutely essential for PspC-dependent expression. PspC is predicted to contain a leucine zipper, a motif responsible for the dimerization of many eukaryotic transcriptional activators. PspB and PspC, though not necessary for psp expression during heat shock, are required for the strong psp response to phage infection, osmotic shock, and ethanol treatment. The psp operon thus represents a third category of transcriptional control mechanisms, in addition to the sigma 32- and sigma E-dependent systems, for genes induced by heat and other stresses.
Transfer of Full-Length Dmd to the Diaphragm Muscle of Dmdmdx/mdx Mice through Systemic Administration of Plasmid DNA (2001)

Mutations in the gene encoding dystrophin, a large cytoskeletal protein in muscle, lead to Duchenne muscular dystrophy (DMD). Affected individuals often die of respiratory failure resulting primarily from diaphragm muscle degeneration. Here we report a new procedure to transfer the full-length dystrophin cDNA into the diaphragm muscle of Dmd(mdx/mdx) mice, which carry a mutation in the dystrophin gene (Dmd). Significant gene transfer was found after intravenous injection of naked plasmid DNA followed by a brief (eight second) occlusion of blood flow at the vena cava. This is the first demonstration of gene transfer into the diaphragm muscle through systemic administration of naked plasmid DNA. The approach has potential application for treatment of DMD.
Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (2012)

Based on these data, we conclude that gluconeogenesis is severely compromised in HCC by IL6-Stat3-mediated activation of miR-23a, which directly targets PGC-1α and G6PC, leading to decreased glucose production.
TRANSPLANTATION (2003)

TRANSPLANTATION I appreciate the comments of Mr. Mahawar. As he correctly states, the manufacturers of Thymoglobulin (SangStat Medical Corporation, Fremont, CA) suggest only the use of a “high flow vein” and not specifically a central vein for the administration of Thymoglobulin. However, many published studies clearly indicate its administration through a central line (1,2). I also agree with the author that many other centers are currently administering Thymoglobulin through peripheral access. The purpose of publishing this article was to more broadly endorse the practice of peripheral administration. Although no formal statistical analysis was performed in regard to postadministration infection, no difference was noted in our ambulatory versus hospitalized patients. Michael R. Marvin
LOCAS – A Low Coverage Assembly Tool for Resequencing Projects (2011)

LOCAS produces excellent results for homology-guided assembly of eukaryotic genomes with short reads and low sequencing depth, and therefore appears to be the assembly tool of choice for the detection of novel sequence variations in this scenario.
<title>Temperature insensitivity of a fiber optic Bragg grating sensor</title> (1996)

Recent findings strongly suggest that the glass in the core of a fiber optic Bragg grating has been periodically compacted resulting not only in residual tension but also in a structural transverse isotropy within the core of the fiber. These effects result in a difference of strain- temperature dependence within and outside the Bragg grating that provides a tool for separation of measurands. Hence temperature compensation can be achieved for a Fabry-Perot interferometer with chirped Bragg gratings as end reflectors when used in conjunction with a pulsed light source. The analysis presents in this paper show that if carefully chirped gratings are used as reflectors in a Fabry-Perot interferometer it is possible to control the optical path imbalance of the sensor such that one measurand can be fully compensated for, e.g. strain or temperature. Mainly temperature compensation is treated since it is considered the primary objective, even though the concept applies for any arbitrary measurand. Several relationships are derived for temperature compensation of Fabry-Perot interferometers with chirped Bragg grating reflectors including both free and embedded sensors. The boundary conditions of an embedded sensor are significantly altered since the surrounding host material superimposes temperature induced and transverse strains that will contribute substantially to the strain field inside the sensor. Simulations were carried out according to a geometric grating model assuming continuous chirp and a strict geometrical reflection criterion. These simulations are illustrating the compensation effect for various load cases to both free sensors and sensors embedded in composite laminates.
The Genetic Incorporation of a Distance Probe into Proteins in Escherichia coli (2006)

The unnatural amino acid p-nitrophenylalanine (pNO2-Phe) was genetically introduced into proteins in Escherichia coli in response to the amber nonsense codon with high fidelity and efficiency by means of an evolved tRNA/aminoacyl-tRNA synthetase pair from Methanocuccus jannaschii. It was shown that pNO2-Phe efficiently quenches the intrinsic fluorescence of Trp in a distance-dependent manner in a model GCN4 basic region leucine zipper (bZIP) protein. Thus, the pNO2-Phe/Trp pair should be a useful biophysical probe of protein structure and function.
The COFDM modulation system: the heart of digital audio broadcasting (1995)

Digital audio broadcasting offers the potential to give every radio in Europe the sound quality of a compact disc. To accomplish this, it requires a rugged method of transmission. The coded orthogonal frequency division multiplexing (COFDM) modulation system was developed to meet this need. The paper describes the reasons why a new modulation process was needed, and explains how the COFDM system has been optimised to meet the requirements.
Rational Design of “Heat Seeking” Drug Loaded Polypeptide Nanoparticles That Thermally Target Solid Tumors (2014)

This paper demonstrates the first example of targeting a solid tumor that is externally heated to 42 °C by "heat seeking" drug-loaded polypeptide nanoparticles. These nanoparticles consist of a thermally responsive elastin-like polypeptide (ELP) conjugated to multiple copies of a hydrophobic cancer drug. To rationally design drug-loaded nanoparticles that exhibit thermal responsiveness in the narrow temperature range between 37 and 42 °C, an analytical model was developed that relates ELP composition and chain length to the nanoparticle phase transition temperature. Suitable candidates were designed based on the predictions of the model and tested in vivo by intravital confocal fluorescence microscopy of solid tumors, which revealed that the nanoparticles aggregate in the vasculature of tumors heated to 42 °C and that the aggregation is reversible as the temperature reverts to 37 °C. Biodistribution studies showed that the most effective strategy to target the nanoparticles to tumors is to thermally cycle the tumors between 37 and 42 °C. These nanoparticles set the stage for the targeted delivery of a range of cancer chemotherapeutics by externally applied mild hyperthermia of solid tumors.
Long-term Experience With Bacillus Calmette-Guerin Therapy of Upper Urinary Tract Transitional Cell Carcinoma in Patients Not Eligible for Surgery (2002)

BCG perfusion therapy of the upper urinary tract for papillary tumors or carcinoma in situ is a valid treatment option with acceptable side effects for patients not amenable to conventional radical surgical therapy. BCG therapy of upper urinary tract urothelial tumors may prevent patients from requiring dialysis and provides cure in those with carcinoma in situ of the upper urinary tract. In this negatively selected patient population BCG buys time for some but does not provide cure except for carcinoma in situ.
Emission Characteristics of a Glow Discharge in a Mixture of Heavy Inert Gases with Iodine Vapor (2005)

The results of a systematic investigation of the emission characteristics of a low-pressure UV excimer-halogen lamp pumped by a longitudinal dc glow discharge are presented. The discharge was initiated in mixtures of heavy inert gases with iodine vapor at a total pressure of 100–2000 Pa and a power deposited into the plasma of 10–100 W. Current-voltage characteristics of the glow discharge and emission spectra of the plasma in the region of 190–360 nm are studied. The radiation intensity at the resonance line of the iodine atom (206.2 nm) and the intensity at the peaks of the XeI(B-X) (253 nm) and I2(B-X) (342 nm) emission bands are analyzed as functions of the pressure and partial composition of the mixtures of Ar, Kr, and Xe with iodine vapor, as well as the electric power of the glow discharge. The most efficient gas mixtures are determined for an electric-discharge UV iodine vapor lamp with continuous-wave emission and a long service life before a change of the mixture is required.
Homozygous Premature Truncation of the HERG Protein (1999)

Background —In long-QT syndrome (LQTS), heterozygosity for a mutation in 1 of the K + channel genes leads to prolongation of the cardiac action potential, because the aberrant protein exhibits “loss of function.” HERG, which is involved in LQT2, is the gene encoding the rapid component of the delayed rectifier, I Kr . Methods and Results —In a consanguineous family, a stillbirth was followed by the premature birth of a child in distress due to ventricular arrhythmia in the presence of QT prolongation. LQTS was diagnosed, β-blocker therapy was begun, and a pacemaker was implanted. She developed well and remained symptom-free for 1.5 years. In the index patient, we identified a duplication of bp 558 to 600 in exon 4 of HERG on both alleles. This will result in a frameshift and a premature stop codon before the S1 domain of the HERG protein. Because it is present on both alleles, no functional I Kr is anticipated. The same mutation was found heterozygously in both parents and homozygously in the stillborn brother. Conclusions —It is concluded that absence of I Kr gives rise to a severe cardiac phenotype, with no indication of malfunction of any other organ.
Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy (2015)

The ability of immune-based cancer therapies to elicit beneficial CD8(+) CTLs is limited by tolerance pathways that inactivate tumor-specific CD4 Th cells. A strategy to bypass this problem is to engage tumor-unrelated CD4 Th cells. Thus, CD4 T cells, regardless of their specificity per se, can boost CD8(+) CTL priming as long as the cognate epitopes are linked via presentation on the same dendritic cell. In this study, we assessed the therapeutic impact of engaging tumor-unrelated CD4 T cells during dual costimulation with CD134 plus CD137 that provide help via the above-mentioned classical linked pathway, as well as provide nonlinked help that facilitates CTL function in T cells not directly responding to cognate Ag. We found that engagement of tumor-unrelated CD4 Th cells dramatically boosted the ability of dual costimulation to control the growth of established B16 melanomas. Surprisingly, this effect depended upon a CD134-dependent component that was extrinsic to the tumor-unrelated CD4 T cells, suggesting that the dual costimulated helper cells are themselves helped by a CD134(+) cell(s). Nevertheless, the delivery of therapeutic help tracked with an increased frequency of tumor-infiltrating granzyme B(+) effector CD8 T cells and a reciprocal decrease in Foxp3(+)CD4(+) cell frequency. Notably, the tumor-unrelated CD4 Th cells also infiltrated the tumors, and their deletion several days following initial T cell priming negated their therapeutic impact. Taken together, dual costimulation programs tumor-unrelated CD4 T cells to deliver therapeutic help during both the priming and effector stages of the antitumor response.
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources (2013)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTHydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable ResourcesRobert-Jan van Putten†‡, Jan C. van der Waal†, Ed de Jong*†, Carolus B. Rasrendra‡⊥, Hero J. Heeres*‡, and Johannes G. de Vries*§∥View Author Information† Avantium Chemicals, Zekeringstraat 29, 1014 BV Amsterdam, the Netherlands‡ Department of Chemical Engineering, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands§ Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, the Netherlands∥ DSM Innovative Synthesis BV, P.O. Box 18, 6160 MD Geleen, the Netherlands⊥ Department of Chemical Engineering, Institut Teknologi Bandung, Ganesha 10, Bandung 40132, Indonesia*E-mail: [email protected] (E.d.J.); [email protected] (H.J.H.); [email protected] (J.G.d.V.).Cite this: Chem. Rev. 2013, 113, 3, 1499–1597Publication Date (Web):February 11, 2013Publication History Received3 May 2012Published online11 February 2013Published inissue 13 March 2013https://pubs.acs.org/doi/10.1021/cr300182khttps://doi.org/10.1021/cr300182kreview-articleACS PublicationsCopyright © 2013 American Chemical SocietyRequest reuse permissionsArticle Views33087Altmetric-Citations2357LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Carbohydrates,Catalysts,Dehydration,Solvents Get e-Alerts
Terawatt KrF/Ti:sapphire hybrid laser system (1993)

A terawatt KrF/Ti:sapphire hybrid laser system with a high contrast between amplified spontaneous emission and the main pulses has been developed with an output energy of 130 mJ in 130-fs pulses. An efficient frequencytripling scheme with Ti:sapphire is demonstrated with an efficiency of 11% in the 100-fs regime with LiB(3)O(5) and beta-BaB(2)O(4).
Allergic cross‐reactions between cat and pig serum albumin (1997)

After observing a patient allergic to cat dander and pork but devoid of other allergies, we prospectively screened patients known to be allergic to cat for a second sensitization to pork. After collecting the sera of 10 young patients found to contain specific IgE to cat dander and pork, we undertook this study to detect the possible cross-reactive allergen, define its molecular characteristics, and evaluate its clinical relevance. Through immunoblotting techniques, cat and porcine serum albumin were found to be jointly recognized molecules. These findings were further analyzed by specific anti-albumin IgE titrations and cross-inhibition experiments. Cat serum albumin cDNA was obtained from cat liver, and the corresponding amino acid sequence was deduced and compared to the known porcine and human serum albumin sequences. Inhibition experiments showed that the spectrum of IgE reactivity to cat serum albumin completely contained IgE reactivity to porcine serum albumin, suggesting that sensitization to cat was the primary event. In two cohorts of cat-allergic persons, the frequency of sensitization to cat serum albumin was found to lie between 14% and 23%. Sensitization to porcine albumin was found to lie between 3% and 10%. About 1/3 of these persons are likely to experience allergic symptoms in relation to pork consumption. Sensitization to cat serum albumin should be considered a useful marker of possible cross-sensitization not only to porcine serum albumin but also to other mammalian serum albumins.
Thermal Ablation of Tumors Using Magnetic Nanoparticles (2002)

The data indicate that the proposed method allows the generation of localized heat spots at the tumor area. According to the histologic analysis and previous investigations the DHD were, in principle, high enough to kill tumor cells. The reasons for the presence of regions of temperature underdosage are discussed in the text. Special attention should be paid on the particle wash out in organs in the vicinity of the breast.