gebhart/patrepeval huggingface dataset:
Myocardial infarct size and ventricular function in rats. (1979)

To define the relationship between infarct size and ventricular performance, we performed hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular performance was assessed under ether anesthesia by measurements of baseline hemodynamics and stressed performance as determined by the peak cardiac output and stroke volume obtained during intravenous volume loading and by the peak left ventricular developed pressure obtained during occlusion of the ascending aorta. Infarct size was determined by planimetry of the endocardial circumference of each of four histological slices of the left ventricle. Rats with small (4-30%) myocardial infarctions had no discernible impairment in either baseline hemodynamics or peak indices of pumping and pressure-generating ability when compared to the sham-operated, noninfarcted rats. Rats with moderate (31-46%) infarctions had normal baseline hemodynamics but reduced peak flow indices and developed pressure. Rats with infarctions greater than 46% had congestive heart failure, with elevated filling pressures, reduced cardiac output, and a minimal capacity to respond to pre- and after load stresses. The entire spectrum of postinfarction ventricular function was observed, from no detectable impairment to congestive failure. In this model of histologically healed myocardial infarction, the impairment of left ventricular function was directly related to the loss of myocardium.
Cyclin-dependent kinases (2014)

Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. The evolutionary expansion of the CDK family in mammals led to the division of CDKs into three cell-cycle-related subfamilies (Cdk1, Cdk4 and Cdk5) and five transcriptional subfamilies (Cdk7, Cdk8, Cdk9, Cdk11 and Cdk20). Unlike the prototypical Cdc28 kinase of budding yeast, most of these CDKs bind one or a few cyclins, consistent with functional specialization during evolution. This review summarizes how, although CDKs are traditionally separated into cell-cycle or transcriptional CDKs, these activities are frequently combined in many family members. Not surprisingly, deregulation of this family of proteins is a hallmark of several diseases, including cancer, and drug-targeted inhibition of specific members has generated very encouraging results in clinical trials.
Visible light-emitting diodes using a-plane GaN–InGaN multiple quantum wells over r-plane sapphire (2004)

We report blue-purple pn-junction light-emitting diodes (LEDs) with a-plane GaN–InGaN multiple quantum well active region. The LEDs were grown over r-plane sapphire substrates. Our study has shown the low pump intensity photoluminencence and electroluminescence to be dominated by emission from the band-tail states which then saturates rapidly giving rise to band-edge emission.
The p21-activated Kinase 3 Implicated in Mental Retardation Regulates Spine Morphogenesis through a Cdc42-dependent Pathway (2007)

The p21-activated kinase 3 (PAK3) is one of the recently identified genes for which mutations lead to nonsyndromic mental retardation. PAK3 is implicated in dendritic spine morphogenesis and is a key regulator of synaptic functions. However, the underlying roles of PAK3 in these processes remain poorly understood. We report here that the three mutations R419X, A365E, and R67C, responsible for mental retardation have different effects on the biological functions of PAK3. The R419X and A365E mutations completely abrogate the kinase activity. The R67C mutation drastically decreases the binding of PAK3 to the small GTPase Cdc42 and impairs its subsequent activation by this GTPase. We also report that PAK3 binds significantly more Cdc42 than Rac1 and is selectively activated by endogenous Cdc42, suggesting that PAK3 is a specific effector of Cdc42. Interestingly, the expression of the three mutated proteins in hippocampal neurons affects spinogenesis differentially. Both kinase-dead mutants slightly decrease the number of spines but profoundly alter spine morphology, whereas expression of the R67C mutant drastically decreases spine density. These results demonstrate that the Cdc42/PAK3 is a key module in dendritic spine formation and synaptic plasticity.
Thrombopoietin Administered During Induction Chemotherapy to Patients With Acute Myeloid Leukemia Induces Transient Morphologic Changes That May Resemble Chronic Myeloproliferative Disorders (2002)

Thrombopoietin (TPO), a potent stimulator of megakaryocyte and platelet production, has been used in clinical trials to reduce thrombocytopenia after chemotherapy in patients with acute myeloid leukemia (AML). We report that TPO therapy is associated with peripheral blood and bone marrow findings that can mimic myeloproliferative disorders. Peripheral blood and bone marrow samples of 13 patients with AML who received TPO were examined. A subset of bone marrow samples exhibited hypercellularity, megakaryocytic hyperplasia, and reticulin fibrosis after TPO administration. Cases demonstrated as many as 58.4 megakaryocytes per high-powerfield (MHPF) compared with 3.7 MHPF in the control group. Megakaryocytic atypia, increased mitoses, emperipolesis, intrasinusoidal megakaryocytes, and thickened trabeculae also were seen. Peripheral blood findings included leukoerythroblastosis, leukocytosis, thrombocytosis, and circulating megakaryocyte nuclei. Changes resolved within 3 months after discontinuation of TPO. This rapid resolution of the morphologic abnormalities induced by TPO distinguishes these findings from those seen in true chronic myeloproliferative disorders.
Cancer cell metabolism: implications for therapeutic targets (2013)

Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked to activation of oncogenes or loss of tumor suppressors, thereby fundamentally advancing cancer progression. In this respect, inhibition of glycolytic capacity may contribute to an anticancer effect on malignant cells. Understanding the mechanisms of aerobic glycolysis may present a new basis for cancer treatment. Accordingly, interrupting lactate fermentation and/or other cancer-promoting metabolic sites may provide a promising strategy to halt tumor development. In this review, we will discuss dysregulated and reprogrammed cancer metabolism followed by clinical relevance of the metabolic enzymes, such as hexokinase, phosphofructokinase, pyruvate kinase M2, lactate dehydrogenase, pyruvate dehydrogenase kinase and glutaminase. The proper intervention of these metabolic sites may provide a therapeutic advantage that can help overcome resistance to chemotherapy or radiotherapy.
Q-switched mode-locking of an erbium-doped fiber laser through subharmonic cavity modulation (2012)

A Q-switched, mode-locked fiber laser based on cavity loss modulation at a subharmonic frequency of the fundamental intermode frequency spacing is experimentally demonstrated. This simple approach is shown to be capable of producing high quality Q-switched, mode-locked pulses.
Neuroleptic piperazinyl-dibenzo-azepines. Chemistry and structure-activity relationships. (1975)

The chemistry and the molecular and physicochemical properties of the 11-piperazinyl derivatives of dibenz[b,f][1,4]-oxazepines and -thiazepines and of dibenzo[b,e][1,4]diazepines as well as those of the 6-piperazinyl-morphanthridines are reviewed. The physicochemical parameters sigma, pK, eta, RM and surface pressure are considered in relation to each other and in relation to two pharmacological effects, namely apomorphine antagonism and cataleptic activities. The influence of substituents, bridging moiety and basic side chain on structure-activity are discussed. Finally, the dibenzodiazepine derivative clozapine, which differs markedly from the classical neuroleptics in its biochemical, pharmacological and clinical properties and represents a new type of antipsychotic agent, is discussed.
Atomic-Resolution Imaging of Oxygen in Perovskite Ceramics (2003)

Using an imaging mode based on the adjustment of a negative value of the spherical-aberration coefficient of the objective lens of a transmission electron microscope, we successfully imaged all types of atomic columns in the dielectric SrTiO3 and the superconductor YBa2Cu3O7. In particular, we were able to view the oxygen atoms which, due to their low scattering power, were not previously accessible, and this allowed us to detect local nonstoichiometries or the degree of oxygen-vacancy ordering. This technique offers interesting opportunities for research into oxides, minerals, and ceramics. In particular, this holds for the huge group of perovskite-derived electroceramic materials in which the local oxygen content sensitively controls the electronic properties.
Cloning of the human brain GABA transporter (1990)

A cDNA clone encoding a transporter for the neurotransmitter gamma-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.
Specificity and Sensitivity of a Human Olfactory Receptor Functionally Expressed in Human Embryonic Kidney 293 Cells andXenopus LaevisOocytes (1999)

Here, we provide the first evidence for functional expression of a human olfactory receptor protein (OR17-40) and show that recombinant olfactory receptors can be functionally expressed in heterologous systems. A mixture of 100 different odorants (Henkel 100) elicited a transient increase in intracellular [Ca(2+)] in human embryonic kidney 293 (HEK293) cells stably or transiently transfected with the plasmid pOR17-40. By subdividing the odorant mixture into progressively smaller groups, we identified a single component that represented the only effective substance: helional. Only the structurally closely related molecule heliotroplyacetone also activated the receptor. Other compounds, including piperonal, safrole, and vanillin, were completely ineffective. Mock-transfected cells and cells transfected with other receptors showed no change in intracellular [Ca(2+)] in response to odor stimulation. We were also able to functionally express OR17-40 in Xenopus laevis oocytes. Coexpression of a "reporter" channel allowed measurement of the response of oocytes injected with the cRNA of the human receptor to the odor mixture Henkel 100. The effective substances were the same (helional, heliotropylacetone) as those identified by functionally expressing the receptor in HEK293 cells and were active at the same, lower micromolar concentration. These findings open the possibility of now characterizing the sensitivity and specificity of many, if not all, of the hundreds of different human olfactory receptors.
Structure and function of the plasminogen/plasmin system (2005)

Activation of the fibrinolytic system is dependent on the conversion of the plasma zymogen, plasminogen (Pg), to the serine protease plasmin (Pm) by the physiological activators urokinase-type Pg activator (uPA) or tissue-type plasminogen activator (tPA). The primary in vivo function of Pm is to regulate vascular patency by degrading fibrin-containing thrombi. However, the identification of Pg/Pm receptors and the ability of Pm to degrade other matrix proteins have implicated Pm in other functions involving degradation of protein barriers, thereby mediating cell migration, an important event in a number of normal e.g., embryogenesis, wound healing, angiogenesis, and pathological, e.g., tumor growth and dissemination, processes. Prior to the development of Pg-deficient mice, much of the evidence for its role in other biological events was based on indirect studies. With the development and characterization of these mice, and ability to apply challenges utilizing a number of animal models that mimic the human condition, a clearer delineation of Pg/Pm function has evolved and has contributed to an understanding of mechanisms associated with a number of pathophysiological events.
Production of bacteremia and meningitis in infant rats with group B streptococcal serotypes (1980)

Group B streptococcal strains, representing the five major serotypes, were inoculated into infant rats by intranasal, oral, and intraperitoneal routes. Bacteremia regularly followed injection by the intraperitoneal route. Four strains (three of type III) isolated from human cerebrospinal fluid appeared more virulent for 5-day-old rats. Injection of fewer than 10 colony-forming units of one strain, a type III, led to bacteremia and death in 27% of animals. The cumulative bacteremia and mortality rate with this strain was 66% in animals given inocula of less than 10 to 10(3) colony-forming units. Bacteremia developed by 24 to 48 h with concentrations of greater than 10(5) colony-forming units per ml of blood, and death occurred soon afterward. Among bacteremic animals, positive cerebrospinal fluid cultures were found in 97%, and cerebrospinal fluid bacterial concentrations were equal to or exceeded bacterial counts in blood. The susceptibility of infant rats to infection with type Ia, Ic, or III strains was age dependent. Histopathological studies of the brain and meninges in 34 bacteremic animals with culture-positive cerebrospinal fluid revealed that 5- to 10-day-old animals had numerous bacteria distributed in a perivascular pattern but, with one exception, no leukocytic infiltration. In contrast, three of the 11- to 12-day-old and two 15-day-old animals had very thickened meninges infiltrated with polymorphonuclear leukocytes, macrophages, and bacteria.
Computational materials synthesis. I. A tight-binding scheme for hydrocarbons (1996)

A simple quantum mechanical model is presented for hydrocarbons. It is a modified version of the model of Davidson and Pickett [Phys. Rev. B 49, 11 253 (1994)]. Self-consistency is introduced through the imposition of local charge neutrality, which is appropriate for hydrogen and carbon based systems due to the small amount of charge transfer that takes place. Further, some parameters have been refitted to give the correct binding energies as well as forces. The model is found to give excellent agreement with experiment and other calculations for hydrocarbon molecules and the hydrogenated surface of diamond, demonstrating its transferability. \textcopyright{} 1996 The American Physical Society.
OX40 costimulation can abrogate Foxp3+ regulatory T cell‐mediated suppression of antitumor immunity (2009)

Regulatory T cells (Tregs) play an important role in maintaining immunological tolerance that is one of the main obstacles to overcome for improving antitumor immunity. Recently, the Treg has been shown to constitutively express OX40 (CD134), which is a member of the TNF-receptor family that is transiently expressed on effector T cells after TCR triggering, and through which the signal enhances effector T-cell proliferation and memory T-cell development. However, little is known about the role of OX40 costimulation to Tregs in tumor immunology. Here we show that OX40 signaling modulates the function of naturally occurring Tregs in vitro and in vivo. Foxp3 expression on Tregs was reduced by OX40 costimulation, but not by IL-2 stimulation. Tregs suppressed the proliferation of naïve CD4(+) CD25(-) T cells after TCR triggering, in contrast, OX40 costimulated Tregs that reduced Foxp3 expression reversed the suppressive function. In addition, Tregs inhibited the proliferation of TCR-stimulated (primed) CD4(+) T cells and naïve CD8(+) T cells after TCR-mediated activation, however, Tregs with OX40 costimulation lost their suppressive function. Interestingly, Tregs minimally suppressed the proliferation or the cytokine secretion of Ag-specific CD8(+) T cells after Ag-restimulation. Furthermore, Tregs suppressive function to the antitumor effect was reversed by OX40 costimulation in vivo. Our data indicate that, in addition to controlling effector T-cell function, OX40 costimulation directly controls Treg-mediated suppression in tumor immunity.
Check! A generic and specific industrial inspection tool (1996)

The authors present an overview of an ‘inspection and control’ package to perform automatic quality control of industrial components, specifically electronic circuit boards. This application has grown out of a set of tools designed initially to aid the development of point distribution models (PDMs) and grey-level models (GLMs) pioneered at the Wolfson Image Analysis Unit in Manchester. These models are both generic and specific. Generic, because they can be applied to most image classification problems; specific, because they aim at the full interpretation of the variability of the objects to be modelled. The underlying vision processing techniques are based on statistical pattern matching. Two synergetic approaches have been followed. The system is trained to recognise the components from either their shape or their grey level appearance or both.
Interchannel interference of OFDM in mobile radio channels (2002)

In this paper, tight and universal bounds are derived for the interchannel interference (ICI) of an OFDM signal resulting from Doppler spread. The universal bound depends only on the product of the maximum Doppler frequency and the OFDM symbol duration. The tight bound also depends on the variance of the Doppler spectrum. Compared with exact ICI expressions derived by other researchers, these bounds are easier to evaluate and can more easily provide useful insight.
Ultra High Efficiency Green Organic Light-Emitting Devices (2006)

We developed ultra high efficiency green organic light-emitting devices (OLEDs) using a novel electron transport material containing dipyridylphenyl moieties and green phosphorescent emitter, fac tris(2-phenylpyridine)iridium, Ir(ppy)3. An OLED with a simple structure of glass/indium–tin oxide/polymer buffer layer/arylamine derivative as a hole transport layer/Ir(ppy)3-doped dicarbazolylbiphenyl as an emitter layer/dipyridylphenyl derivative as an electron transport layer/LiF/Al exhibited low drive voltages, which were 2.5 V at 100 cd/m2 and 2.9 V at 1000 cd/m2. High external quantum efficiencies of 29% at 100 cd/m2 and 26% at 1000 cd/m2 were also observed, which lead to the ultra high power efficiencies of 133 lm/W at 100 cd/m2 and 107 lm/W at 1000 cd/m2.
Baxter: A high-resolution penta-source marine 3D seismic acquisition (2016)

The penta-source towed streamer acquisition configuration is designed to produce high-resolution cross-line data sampling with conventional acquisition technologies that do not require specialist algorithms to process, and with source deblending can achieve an arbitrary record length The Baxter 3D survey was acquired with the penta-source design along with a subset conventional survey for reference. The penta-source survey was successfully acquired with no significant issues encountered in the field. A preliminary fast-track processing sequence shows that a significant improvement in resolution has been achieved by the penta-source technique. The full processing sequence continues with the expectation that further improvements will be realized. Presentation Date: Thursday, October 20, 2016 Start Time: 9:20:00 AM Location: 163/165 Presentation Type: ORAL
ZAMBEZI HYDRO-ELECTRIC DEVELOPMENT AT KARIBA, FIRST STAGE. (INCLUDES PLATES & APPENDICES)> (1960)

Keywords FEDERAL POWER BOARD, SIR ALEXANDER GIBB, MERZ AND MCLELLAN HYDROELECTRICITY, DEVELOPMENT, CONSTRUCTION, POWER, RIVERS, ENERGY, WATER, ELECTRICITY, COUNTRIES, DEVELOPING, DOUBLE, CURVATURE, CONCRETE, ARCHES, DAMS, UNDERGROUND, POWER HOUSES, TURBOGENERATORS, LAKES, NATURAL, RESERVOIRS, DESIGN, PLANNING, ORGANISATION, MANAGEMENT, HYDROLOGY, GEOLOGY, INTAKES, MACHINERY, HALLS, GENERATORS, PLANT, SWITCHING, STATIONS, POWER STATIONS, DRAFT, TUBES, SURGES, CHAMBERS, TAILRACE, TUNNELS, FINANCE, ECONOMICS RIVER ZAMBEZI, KARIBA GORGE, RIVER ZAMBESI, KARIBA DAM RHODESIA, NYASALAND, ZAMBIA, ZIMBABWE, AFRICA... Show All
The nature and outcome of infection in systemic lupus erythematosus (2002)

Infection remains a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). To describe the nature and outcomes of infection and determine their associated risk factors in patients with SLE, we performed a nested case-control study at the University of Toronto Lupus Clinic, with prospective follow-up according to a standard protocol since 1970. Cases were SLE patients seen between January 1987 and January 1992 who had documented infections and controls were patients without infection from the same cohort matched for age, gender and time of visit. The type, site and outcome of infection were recorded for each case. A conditional logistic regression analysis was performed to compare factors associated with infection in cases and their controls. Ninety-three patients had 148 infection episodes; the majority were bacterial, but viral, fungal and protozoan organisms were also identified (multiple organisms in seven). Forty-eight patients required hospital admission and three patients died. Steroids at time of infection, as well as use ever, duration and dose, immunosuppressives at time of infection and use ever, active renal disease, CNS damage, SLEDAI at the time of infection, adjusted mean SLEDAI and variability measure were significantly associated with infection by univariate analysis. By multivariate analysis one factor remained statistically significant: use of steroids ever (P = 0.029). Infection carries a large burden for SLE patients. Until new medications which will control disease activity without predisposing to infection are developed, careful titration of steroids and cytotoxic drugs to control disease activity will remain crucial.
ChemInform Abstract: An Alternative CuCl—Piperidine‐Catalyzed Oxidative Homocoupling of Terminal Alkynes Affording 1,3‐Diynes in Air. (2010)

Abstract Oxidative homocoupling of terminal alkynes can be carried out under air in the presence of CuCl—piperidine catalyst to give 1,3‐diynes (II), (IV) in high to excellent yields.
Plasma thrombospondin levels in patients with gynecologic malignancies (1994)

Tumor-synthesized thrombospondin could explain the elevated levels in the patent group and also the observation of the correlation between the thrombospondin level and tumor burden. Its function as an adhesive protein may allow it to act as the mediator of metastases. thrombospondin may promote or mediate the metastatic process through its function in cell adhesion.
300 Faces in-the-Wild Challenge: The First Facial Landmark Localization Challenge (2013)

Automatic facial point detection plays arguably the most important role in face analysis. Several methods have been proposed which reported their results on databases of both constrained and unconstrained conditions. Most of these databases provide annotations with different mark-ups and in some cases the are problems related to the accuracy of the fiducial points. The aforementioned issues as well as the lack of a evaluation protocol makes it difficult to compare performance between different systems. In this paper, we present the 300 Faces in-the-Wild Challenge: The first facial landmark localization Challenge which is held in conjunction with the International Conference on Computer Vision 2013, Sydney, Australia. The main goal of this challenge is to compare the performance of different methods on a new-collected dataset using the same evaluation protocol and the same mark-up and hence to develop the first standardized benchmark for facial landmark localization.