gebhart/patrepeval huggingface dataset:
High-fidelity quantum state evolution in imperfect photonic integrated circuits (2015)

We propose and analyze the design of a programmable photonic integrated circuit for high-fidelity quantum computation and simulation. We demonstrate that the reconfigurability of our design allows us to overcome two major impediments to quantum optics on a chip: it removes the need for a full fabrication cycle for each experiment and allows for compensation of fabrication errors using numerical optimization techniques. Under a pessimistic fabrication model for the silicon-on-insulator process, we demonstrate a dramatic fidelity improvement for the linear optics controlled-not and controlled-phase gates and, showing the scalability of this approach, the iterative phase estimation algorithm built from individually optimized gates. We also propose and simulate an experiment that the programmability of our system would enable: a statistically robust study of the evolution of entangled photons in disordered quantum walks. Overall, our results suggest that existing fabrication processes are sufficient to build a quantum photonic processor capable of high-fidelity operation.
Outer Membrane Protein-Specific Monoclonal Antibodies Protect SCID Mice from Fatal Infection by the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis (2001)

Previous studies of Ehrlichia chaffeensis infection in the mouse have demonstrated that passive transfer of polyclonal Abs from resistant immunocompetent mice to susceptible SCID mice ameliorated infection and disease, even when Abs were administered during established infection. To identify particular Abs that could mediate bacterial clearance in vivo, E. chaffeensis-specific mAbs were generated and administered to infected SCID mice. Bacterial infection in the livers was significantly lowered after administration of either of two Abs of different isotypes (IgG2a and IgG3). Moreover, repeated administration of one Ab (Ec56.5; IgG2a) rescued mice from an otherwise lethal infection for at least 5 wk. Both protective Abs recognized the E. chaffeensis major outer membrane protein (OMP)-1g. Further studies revealed that both Abs recognized closely related epitopes within the amino terminus of the first hypervariable region of OMP-1g. Analyses of human sera showed that E. chaffeensis-infected patients also generated serological responses to OMP-1g hypervariable region 1, indicating that humans and mice recognize identical or closely related epitopes. These studies demonstrate that OMP-specific mAbs can mediate bacterial elimination in SCID mice, and indicate that Abs, in the absence of cell-mediated immunity, can play a significant role in host defense during infection by this obligate intracellular bacterium.
Surgical treatment of ovarian dermoid cysts: a clinical evaluation between vaginal and laparoscopic removal (2005)

Objective: This study was conducted to compare the results between vaginal and laparoscopic removal for surgical treatment of ovarian dermoid cysts. Methods: This retrospective study was performed in 228 patients, who underwent vaginal (Group A: 159) or laparoscopic (Group B: 69) removal of ovarian dermoid cysts between January 1998 and May 2004. The vaginal removal was performed after reduction of mass size by suction of its contents, and laparoscopic removals with Lapbag. Results: The mean age was 37.79.7 years in Group A and 30.59.2 years in Group B. The number of patients had a previous abdominal open surgery was 30 (17.8%) in Group A and 15 (21.7%) in Group B. The mean diameter of the ovarian dermoid cysts was 6.12.1 cm in Group A and 5.72.0 cm in Group B. The differences between preoperative and postoperative hemoglobin was 1.81.4 g/dL in Group A and 1.50.8 g/dL in Group B (p16 minutes in Group A and 8236 minutes in Group B (p 24h after surgery) was 3 (1.7%) in Group A and 2 (2.8%) in Group B. The feeling of satisfaction was very high in both groups. Conclusion: Both vaginal and laparoscopic removal of ovarian dermoid cysts are useful and effective treatment. However, the vaginal removal have cheap hospital expenses, shorter operating time, and no surgical trauma on abdominal wall. So, it have great advantages compare with laparoscopic removal. Vaginal removal can be considered a useful alternative procedure.
Adeno-Associated Virus Serotype 9–Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts With Left Ventricular Dysfunction Secondary to a Myocardial Infarction (2016)

The results suggest that BAG3 gene therapy may provide a novel therapeutic option for the treatment of heart failure.
Search for new industrial oils: XVI. Umbelliflorae—seed oils rich in petroselinic acid (1982)

Abstract Seed oils of the order Umbelliflorae, including those from the families Umbelliferae, Garryaceae, Araliaceae, Cornaceae, Davidiaceae, Nyssaceae and Alangiaceae, were analyzed for fatty acid composition by gas liquid chromatography (GLC) of their methyl esters. The characteristic fatty acid of the order, petroselinic acid, occurred in the Umbelliferae in amounts up to 85%. In the Araliaceae, the content was as high as 83% and in the Garryaceae as high as 81%. The other major acids were palmitic, oleic and linoleic acids, with small amounts of hexadecenoic, stearic, linolenic, and, in some cases, C 20 acids. petroselinic acid was determined by microscale ozonolysis of the C 18 monoenoic esters and subsequent GLC of the ozonolysis products. The occurrence of high oil contents (up to 46%) combined with exceptionally high (up to 83%) single component purity is notable and emphasizes the potential of the Umbelliflorae as a raw material source for the chemical industry.
Controlled reagent transport in disposable 2D paper networks (2010)

Recent reports have demonstrated the multi-analyte detection capability of paper networks with multiple outlets per inlet. In this report, we focus on the capabilities of 2D paper networks with multiple inlets per outlet and demonstrate the controlled transport of reagents within paper devices. Specifically, we demonstrate methods of controlling fluid transport using the geometry of the network and dissolvable barriers. Finally, we discuss the implications for higher sensitivity detection using this type of 2D paper network.
A comparative study of location aided routing protocols for MANET (2011)

Location-aided routing (LAR) is a mechanism which attempts to reduce the control message overhead of Ad-hoc on-demand distance vector (AODV) routing protocol by flooding only the portion of the network that is likely to contain the route to destination. LAR takes advantage of Global Positioning System (GPS) coordinates to identify a possible location of the destination node. Based on this information, LAR defines a portion of the network which will be subject to the limited flooding, thus reducing the total number of the control packet traveling through the network during the route discovery process. GeoAODV is a variation of the AODV protocol which like LAR also employs GPS coordinates to limit the search area used during the route discovery process. However, unlike LAR, GeoAODV does not make the assumption that every node in the network knows the traveling speed and location of the corresponding destination node. Instead, GeoAODV tries to dynamically learn and distribute location information among the nodes in the network. This paper examines and compares through simulation the performance of AODV, LAR, and GeoAODV protocols under different environmental settings.
New telomeres in yeast are initiated with a highly selected subset of TG1-3 repeats. (1993)

The creation of new telomeres was studied by generating a site-specific double-strand break in diploid strains of Saccharomyces cerevisiae that are unable to carry out homologous recombination. New telomere formation occurred approximately 1% of the time but only when (T2G4)13 was present proximal to the break site. About half of the healing events occurred at a number of 1- to 9-bp G or G, T sequences located as far as 128 bp distal to the T2G4 repeats. Surprisingly, in 16 events at sites ending in GTGG, the first TG1-3 nucleotides added always included either an 11- or a 13-bp sequence (GTGTGGGTGTG or GTGTGTGGGTGTG), after which each new telomere diverged into a less ordered TG1-3 pattern. Moreover, at 75% of the remaining addition sites, these same 11- or 13-bp sequences were found overlapping the junction between the chromosomal primer and the newly added sequences. We propose that short G, T sequences near an organizing sequence such as (T2G4)13 can act as primers to pair with the template RNA of a telomerase and add new sequences that are complementary to that RNA.
Adenosine A2A receptor enhances GABAA‐mediated IPSCs in the rat globus pallidus (2001)

1. The actions of adenosine A(2A) receptor agonists were examined on GABAergic synaptic transmission in the globus pallidus (GP) in rat brain slices using whole-cell patch-clamp recording. GP neurones were characterized into two major groups, type I and type II, according to the degree of time-dependent hyperpolarization-activated inward rectification and the size of input resistance. 2. The A(2A) receptor agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamido- adenosine (CGS21680; 0.3-3 microM) enhanced IPSCs evoked by stimulation within the GP. The actions of CGS21680 were blocked by the A(2A) antagonists (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (KF17837) and 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM241385). 3. The CGS21680-induced increase in IPSCs was associated with a reduction in paired-pulse facilitation. CGS21680 (0.3 microM) increased the frequency of miniature IPSCs (mIPSCs) without affecting mIPSC amplitude. These observations demonstrated that the enhancement of IPSCs in the GP was attributable to presynaptic, but not postsynaptic, A(2A) receptors. 4. The results suggest that A(2A) receptors in the GP serve to inhibit GP neuronal activity, thereby disinhibiting subthalamic nucleus neurone activity. Thus, the A(2A) receptor-mediated presynaptic regulation in the GP, together with the A(2A) receptor-mediated intrastriatal presynaptic control of GABAergic neurotransmission described previously, may play a crucial role in controlling the neuronal functions of basal ganglia. This A(2A) receptor-mediated presynaptic dual control in the striatopallidal pathway could also afford the mode of action of A(2A) antagonists for ameliorating the symptoms of Parkinson's disease in an animal model.
Role of BAX in the Apoptotic Response to Anticancer Agents (2000)

To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects of the chemotherapeutic agent 5-fluorouracil, but apoptosis was not abolished. In contrast, the absence of BAX completely abolished the apoptotic response to the chemopreventive agent sulindac and other nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibited the expression of the antiapoptotic protein Bcl-XL, resulting in an altered ratio of BAX to Bcl-XL and subsequent mitochondria-mediated cell death. These results establish an unambiguous role for BAX in apoptotic processes in human epithelial cancers and may have implications for cancer chemoprevention strategies.
Facilitation of the Induction of Long-term Potentiation by GABA B Receptors (1991)

Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.
Azoic Diazo Components Containing Pyrazolone Ring. (1959)

ピラゾロン環をナフトール染料顕色剤に導入しその色調および染色堅ろう度について考察した。顕色剤はいずれもピラゾロン環の4-位にアゾ基で結合しているフェニル核にアミノ基を導入したもので,ピラゾロン類にジアゾ化したアシル-アミノアニリン類をカップリングし,ついで加水分解する方法か,あるいはジアゾ化したニトロアニリン類をカップリングし,ついで還元する方法によってアミノ化合物を合成した。合成したアミノ化合物は,3-メチル-4-(4'-アミノフェニルアゾ)-5-ピラゾロン(I),1-フェニル-(II)-,1-(β-ナフチル)-3-メチル-4-(4'-アミノフェニルアゾ)-5-ピラゾロン(III),4-(3'-アミノフェニルアゾ)(IV)-,4-(3'-トリフルオルメチル- 4'-アミノフェニルアゾ) (V)-,4-(2', 5'-ジエトキシ-4'-アミノフェニルアゾ)-1-フェニル-3-メチル-5-ピラゾロン(VI)および4-[4'-(4''-アミノフェニルアゾ)-フェニルアゾ](VII)-,4-[2',5'-ジメトキシ-4'-(4''-アミノフェニルアゾ)-フェニルアゾ] (VIII)-,4-[2', 5'-ジメトキシ-4'-(2'', 6''-ジクロル-4''-アミノフェニルアゾ)-フェニルアゾ]-1-フェニル-3-メチル-5-ピラゾロン(IX)である。ナフトールAS類と組合わせて木綿上で顕色した結果,(I),(II),(III)は紫色系,(IV)は赤色系,(V)は赤紫色系,(VI)は青色系,(VII),(VIII),(IX)は黒色にそれぞれ顕色した。日光堅ろう度は(I),(II)以外はすぐれていて,洗たく,摩擦堅ろう度も(I),(II),(III)以外は優秀であった。
Immunotherapy with MVA-BN®-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells (2011)

MVA-BN®-HER2 is a new candidate immunotherapy designed for the treatment of HER-2-positive breast cancer. Here, we demonstrate that a single treatment with MVA-BN®-HER2 exerts potent anti-tumor efficacy in a murine model of experimental pulmonary metastasis. This anti-tumor efficacy occurred despite a strong tumor-mediated immunosuppressive environment characterized by a high frequency of regulatory T cells (T(reg)) in the lungs of tumor-bearing mice. Immunogenicity studies showed that treatment with MVA-BN®-HER2 induced strongly Th1-dominated HER-2-specific antibody and T-cell responses. MVA-BN®-HER2-induced anti-tumor activity was characterized by an increased infiltration of lungs with highly activated, HER-2-specific, CD8+CD11c+ T cells accompanied by a decrease in the frequency of T(reg) cells in the lung, resulting in a significantly increased ratio of effector T cells to T(reg) cells. In contrast, administration of HER2 protein formulated in Complete Freund's Adjuvant (CFA) induced a strongly Th2-biased immune response to HER-2. However, this did not lead to significant infiltration of the tumor-bearing lungs by CD8+ T cells or the decrease in the frequency of T(reg) cells nor did it result in anti-tumor efficacy. In vivo depletion of CD8+ cells confirmed that CD8 T cells were required for the anti-tumor activity of MVA-BN®-HER2. Furthermore, depletion of CD4+ or CD25+ cells demonstrated that tumor-induced T(reg) cells promoted tumor growth and that CD4 effector cells also contribute to MVA-BN®-HER2-mediated anti-tumor efficacy. Taken together, our data demonstrate that treatment with MVA-BN®-HER2 controls tumor growth through mechanisms including the induction of Th1-biased HER-2-specific immune responses and the control of tumor-mediated immunosuppression.
3′‐Substituted and 2′,3′‐Unsaturated 7‐Deazaguanine 2′,3′‐Dideoxynucleosides: Syntheses and Inhibition of HIV‐1 Reverse Transcriptase (1991)

Abstract The syntheses of 2′,3′‐dideoxy‐2′,3′‐didehydro‐β‐ D ‐ribofuranoside 1 and 2′,3′‐dideoxy‐3′‐fluoro‐β‐ D ‐ribo‐furanoside 5 of 7‐deazaguanine as well as 7‐deaza‐2′‐deoxyxyloguanosine ( 3 ) are described. The corresponding 2,4‐diamino compounds 2 and 4 were also prepared. Thus, silytation of 2‐amino‐4‐chloro‐7‐(2‐deoxy‐β‐ D ‐ erythro ‐pentofuranosyl)‐7 H ‐pyrrolo[2,3‐ d ]pyrimidine ( 6 ) afforded 7 , which gave the oxo‐nucleoside 13 after oxidation with CrO 3 . NaBH 4 reduction yielded 14 which, upon deprotection (Bu 4 NF) and nucieophific displacement, afforded 3 and 4 . On the other hand, the N 2 ‐formyl derivative of 7 was mesylated (→ 10 ), treated with Bu 4 NF, and deprotected with NH 3 yielding the 2′,3′‐dideoxy‐2′,3′‐didehydro‐nucleoside 12 , Nucleophilic displacement reactions on 12 yielded 1 and 2 . The fluoro‐nucleoside 5 was obtained from 14 after methoxytritylation of the NH 2 group (→ 16 ), fluorination with DAST (→ 17), and treatment with 2M NaOH. The 5′‐triphosphates of 5 and other pyrrolo[2,3‐ d ]pyrimidine 2′,3′‐dideoxy‐3′‐fluoro‐nucleosides were found to be highly active inhibitors of HIV‐1. reverse transcriptase, similar to those of 1 and 2 .
Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. (1993)

To probe the ligand receptor interface, a number of point mutations were introduced in selected regions of human tumor necrosis factor (TNF) alpha by site-directed mutagenesis. The mutated proteins were expressed in Escherichia coli and analyzed for selective binding to recombinant 55- and 75-kDa TNF receptors in competition with radiolabeled wild-type TNF alpha. Generally, mutations in the loop from position 29 to 34 and at positions 86 and 146 preferentially impaired binding to the 75-kDa TNF receptor, whereas mutations in the region from 143 to 145 mainly affected binding to the 55-kDa TNF receptor. Mutation of the conserved Tyr87 resulted in a dramatic loss of binding activity to both receptors. The selectivity for one or the other receptor type was found to be enhanced by combining two or three point mutations, the effects of the single mutations with respect to receptor selectivity being at least additive. A combination of the mutations Arg32-->Trp and Ser86-->Thr yielded a double mutant (R32W-S86T) with wild-type binding to the 55 kDa, but no measurable binding to the 75-kDa TNF receptor. In contrast, combining the Asp143-->Asn and Ala145-->Arg mutations (D143N-A145R) resulted in a complete loss of binding to the 55-kDa TNF receptor, whereas binding to the 75-kDa TNF receptor was impaired by only 5-10-fold. In functional assays, selective activation of the 55-kDa TNF receptor by the R32W-S86T mutant elicited a full cytotoxic response in human KYM-1 cells and secretion of interleukin 6 and granulocyte-macrophate colony-stimulating factor in human umbilical vein endothelial cells. In contrast, stimulation of the 75-kDa TNF receptor with the D143N-A145R mutant as well as with agonistic antibodies failed to induce these responses.
Transfer of Nitrate Reductase Genes of the Cyanobacterium Nostoc muscorum into Rhizobium japonicum (1983)

Transformation of Rhizobium japonicum CB1809 was studied using DNA from the cyanobacterium Nostoc muscorum ATCC 27893. A spontaneous nitrate reductase deficient (Nar-) mutant (NR-6) of R. japonicum CB1809 was isolated with a frequency of 8.4 X 10(-7). Streptomycin (Sm) and Neomycin (Neo) resistance markers were introduced into strain NR-6, and the resulting strain was designated NR-6 SmR NeoR. Experiments with cyanobacterial DNA and live cells of strain NR-6 SmR NeoR indicated transformation of nitrate reductase (nar) genes of N. muscorum into this strain. This conclusion was supported by the reversion frequency of strain NR-6 SmR NeoR to Nar+ and the transformation frequency when recipient cells were exposed to N. muscorum DNA (with heat-treated DNA as control). Comparisons of growth, nitrate uptake, assimilatory nitrate reductase activity and nodulation of parent CB1809, NR-6 SmR NeoR and five transformant clones (Nar+) suggest that there may be considerable homology between the nar genes of R. japonicum CB1809 and N. muscorum.
High Mobility Thin Film Transistors with Transparent ZnO Channels (2003)

We have fabricated high performance ZnO thin film transistors (TFTs) using CaHfO x buffer layer between ZnO channel and amorphous silicon–nitride gate insulator. The TFT structure, dimensions, and materials set are identical to those of the commercial amorphous silicon (a-Si) TFTs in active matrix liquid crystal display, except for the channel and buffer layers replacing a-Si. The field effect mobility can be as high as 7 cm 2 ·V -1 ·s -1 for devices with maximum process temperature of 300°C. The process temperature can be reduced to 150°C without much degrading the performance, showing the possibility of the use of polymer substrate.
β-Glucosidase from the Grape Native YeastDebaryomyces vanrijiae: Purification, Characterization, and Its Effect on Monoterpene Content of a Muscat Grape Juice (2003)

Six hundred ten yeast colonies isolated from various vineyards in Chile were screened for the presence of a beta-glucosidase activity as well as the resistance to glucose and ethanol inhibition. Among them, Debaryomyces vanrijiae was found to produce high levels of an extracelular beta-glucosidase which was tolerant to glucose (K(i) = 439 mM) and ethanol inhibitions. The enzyme (designated DV-BG) was purified to apparent homogeneity, respectively, by gel filtration, ion-exchange, and chromatofocusing techniques. Its molecular weight was 100 000, and its pI 3.0, optimum pH, and temperature activities were 5.0 and 40 degrees C, respectively, and had a V(max) of 47.6 micromol min(-)(1) mg(-)(1) and a K(m) of 1.07 mM. The enzyme was active against different beta-d-glucosides including glucosidic flavor precursors. The disaccharidic flavor precursors were not substrates for the enzyme. When added to a Muscat grape juice, the concentration of several monoterpenes increased as the consequence of its hydrolytic activity.
Antioxidant Status in Patients with Cystic Fibrosis (2000)

On the basis of the present results this regime failed to provide sufficient antioxidant protection. Therefore, the authors suggest that the daily dose of these antioxidants should be either increased or to administer in parenteral route to patients with severe form of the disease.
Molecular evolution of the telomere-associated MAL loci of Saccharomyces. (1989)

The MAL gene family of Saccharomyces consists of five multigene complexes (MAL1, MAL2, MAL3, MAL4, and MAL6) each of which encodes maltose permease (GENE 1), maltase (GENE 2) and the trans-acting MAL-activator (GENE 3). Four of these loci have been mapped and each is located at or near the telomere of a different chromosome. We compare the physical structure of the MAL loci and their flanking sequences. The MAL loci were shown to be both structurally and functionally homologous throughout an approximately 9.0-kb region. The orientation of the MAL loci was determined to be: CENTROMERE . . . GENE 3-GENE 1-GENE 2 . . . TELOMERE. Telomere-adjacent sequences were found flanking GENE 2 of the MAL1, MAL3 and MAL6 loci. No common repeated elements were found on the centromere-proximal side of all the MAL1, loci. These results suggest that, during the evolution of this polygenic family, the MAL loci translocated to different chromosomes via a mechanism that involved the rearrangement(s) of chromosome termini.
Monoclonal antibody to type IV collagen with selective basement membrane localization. (1984)

A monoclonal antibody (MCA IV-1) has been developed to a determinant of the high molecular weight fractions of human placental collagen, present also in bovine lens capsule and glomerular basement membrane type IV collagens. This unique determinant is pepsin and collagenase resistant and is apparently distinct from the alpha 1(IV) and alpha 2(IV) helical peptides. As part of the high molecular weight molecules, the determinant is located in a region additively deformable by reduction and sodium dodecyl sulfate denaturation. However, when a 20-kilodalton, largely collageneous, fragment containing this determinant is separated from the larger fraction by 37 degrees C collagenase treatment, the determinant is insensitive to reduction or sodium dodecyl sulfate denaturation. Immunohistologic analysis and comparison with a polyclonal antibody to type IV collagen shows a marked selectivity of localization in the glomerular basement membrane. MCA IV-1 reacts in the inner aspect of the glomerular basement membrane but primarily in the mesangium, where it selectively expands in diabetic nephropathy. Tissue selectivity is also evident in lens and corneal basement membrane.
Mechanisms of platelet aggregation (2001)

Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.