gebhart/patrepeval huggingface dataset:
Furo-chromones and -Coumarins. XIV. 2-(3'-Pyridyl) Analogs of Khellin and Visnagin (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFuro-chromones and -Coumarins. XIV. 2-(3'-Pyridyl) Analogs of Khellin and VisnaginAlexander Schönberg, Nasry Badran, and Nicolas A. StarkowskyCite this: J. Am. Chem. Soc. 1955, 77, 20, 5439–5440Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October 1955https://pubs.acs.org/doi/10.1021/ja01625a084https://doi.org/10.1021/ja01625a084research-articleACS PublicationsRequest reuse permissionsArticle Views46Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer (2016)

Activating mutations of K-ras are the most common oncogenic alterations found in lung cancer. Unfortunately, attempts to target K-ras-mutant lung tumors have thus far failed, clearly indicating the need for new approaches in patients with this molecular profile. We have previously shown NF-κB activation, release of IL6, and activation of its responsive transcription factor STAT3 in K-ras-mutant lung tumors, which was further amplified by the tumor-enhancing effect of chronic obstructive pulmonary disease (COPD)-type airway inflammation. These findings suggest an essential role for this inflammatory pathway in K-ras-mutant lung tumorigenesis and its enhancement by COPD. Therefore, here we blocked IL6 using a monoclonal anti-IL6 antibody in a K-ras-mutant mouse model of lung cancer in the absence or presence of COPD-type airway inflammation. IL6 blockade significantly inhibited lung cancer promotion, tumor cell-intrinsic STAT3 activation, tumor cell proliferation, and angiogenesis markers. Moreover, IL6 inhibition reduced expression of protumor type 2 molecules (arginase 1, Fizz 1, Mgl, and IDO), number of M2-type macrophages and granulocytic myeloid-derived suppressor cells, and protumor T-regulatory/Th17 cell responses. This was accompanied by increased expression of antitumor type 1 molecule (Nos2), and antitumor Th1/CD8 T-cell responses. Our study demonstrates that IL6 blockade not only has direct intrinsic inhibitory effect on tumor cells, but also reeducates the lung microenvironment toward an antitumor phenotype by altering the relative proportion between protumor and antitumor immune cells. This information introduces IL6 as a potential druggable target for prevention and treatment of K-ras-mutant lung tumors. Cancer Res; 76(11); 3189-99. ©2016 AACR.
Combination therapy in rheumatoid arthritis: updated systematic review (1998)

In a second update of a systematic review, many new developments in the combined drug treatment of rheumatoid arthritis (RA) are highlighted. In early RA patients, step-down bridge therapy that includes corticosteroids leads to much enhanced efficacy at acceptable or low toxicity. The effects on joint damage may be persistent, but the symptomatic effects are probably dependent on continued corticosteroid dosing. In late patients, cyclosporin improves a suboptimal clinical response to methotrexate, and the triple combination of methotrexate, sulphasalazine and hydroxychloroquine appears to be clinically better than the components. Other combinations are either untested, tested at low sample size, or show negative interaction. In view of the low volume of evidence, most studies need confirmation by replication.
Long Optical Paths of Large Aperture (1942)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text John U. White, "Long Optical Paths of Large Aperture," J. Opt. Soc. Am. 32, 285-288 (1942) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A mathematical model and a computerized simulation of PCR using complex templates (1996)

A mathematical model and a computer simulation were used to study PCR specificity. The model describes the occurrences of non-targeted PCR products formed through random primer-template interactions. The PCR simulation scans DNA sequence databases with primers pairs. According to the model prediction, PCR with complex templates should rarely yield non-targeted products under typical reaction conditions. This is surprising as such products are often amplified in real PCR under conditions optimized for stringency. The causes for this 'PCR paradox' were investigated by comparing the model predictions with simulation results. We found that deviations from randomness in sequences from real genomes could not explain the frequent occurrence of non-targeted products in real PCR. The most likely explanation to the 'PCR paradox' is a relatively high tolerance of PCR to mismatches. The model also predicts that mismatch tolerance has the strongest effect on the number of non-targeted products, followed by primer length, template size and product size limit. The model and the simulation can be utilized for PCR studies, primer design and probing DNA uniqueness and randomness.
Stacking Faults as Quantum Wells for Excitons in Wurtzite GaN (1997)

A model of the exciton bound to stacking faults (SF) in GaN is suggested. It is shown that SFs are potential wells (depth ≈︂120 meV and width ≈︂10 Å) for electrons and potential barriers (height ≈︂60 meV and width ≈︂10 Å) for holes. The binding energy of excitons at SF found from variational calculation is 45 meV. The 364 nm line in GaN photoluminescence at 4 K is attributed to excitons bound to SFs.
Tumor Immunity Produced by the Intradermal Inoculation of Living Tumor Cells and Living Mycobacterium bovis (Strain BCG) (1970)

The intradermal inoculation of mixtures containing living tumor cells and living Mycobacterium bovis (strain BCG) into unimmunized syngeneic guinea pigs results in an inflammatory reaction to the BCG, and there is no progressive tumor growth. In the absence of BCG the tumor grows progressively, metastasizes, and kills the animal. By conventional methods, it has not been possible to immunize syngeneic guinea pigs to the tumor used. Guinea pigs that receive mixtures of BCG and tumor cells, however, develop specific systemic tumor immunity as measured by delayed cutaneous hypersensitivity and by suppression of tumor growth.
Predicting the grade of Banff 97 classification of chronic allograft nephropathy based on examination of graft dysfunction (a preliminary report). (2003)

Our findings support the assumption that Scr > 275 mumol/l and Ccr < 33.6 ml/min/1.73 m2 suggest a Banff CAN grade higher than 1 (P < 0.001). Proteinuria had the lowest predictive values. Values > 0.40 g/24 hr were probably associated with a Banff CAN grade higher than 1 (p < 0.05).
Use of monoclonal antibody directed against herpes simplex virus glycoproteins to protect mice against acute virus-induced neurological disease (1981)

Monoclonal antibodies HCl and HD1, directed against herpes simplex virus type 1 (HSV-1) glycoproteins gC and gD, respectively, were evaluated for their ability to passively immunize mice against acute virus-induced neurological disease after footpad inoculation with HSV-1 or herpes simplex virus type 2 (HSV-2). Control virus-infected mice receiving a single intraperitoneal injection of normal serum died within 7 to 10 days after the spread of virus from footpad to spinal cord and brain. However, a single intraperitoneal injection of either HCl or HD1 antibody protected mice from neurological illness and death when administered to HSV-1 (strain HTZ)-infected mice at either 2 h before virus challenge or at 24 h after virus inoculation. To determine the in vivo specificity of the antibodies, passive transfer studies were performed with mice infected with the MP strain of HSV-1, a mutant of HSV-1 (mP) which is defective in the production of glycoprotein gC. Whereas HD1 antibody decreased the incidence of neurological illness in MP- and mP-infected mice, HCl antibody, which protected mP-infected animals, failed to protect mice infected with the MP strain. When HD1 antibody was administered to HSV-2 (strain G)-infected mice at either 2 h before virus challenge or at 6 h (but not 24 h) after virus inoculation, 100% of the infected animals receiving HD1 antibody survived. In contrast, 100% of HSV-2 (strain G)-infected animals passively immunized with HCl antibody developed neurological illness and died. These results provide in vivo evidence that the HSV-induced glycoprotein gC expresses type-specific antigenic determinants, whereas glycoprotein gD expresses type-common determinants.
Discovery and Classification of Ecological Diversity in the Bacterial World: The Role of DNA Sequence Data (1997)

All living organisms fall into discrete clusters of closely related individuals on the basis of gene sequence similarity. Evolutionary genetic theory predicts that in the bacterial world, each sequence similarity cluster should correspond to an ecologically distinct population. Indeed, surveys of sequence diversity in protein-coding genes show that sequence clusters correspond to ecological populations. Future population surveys of protein-coding gene sequences can be expected to disclose many previously unknown ecological populations of bacteria. Sequence similarity clustering in protein-coding genes is recommended as a primary criterion for demarcating taxa.
Effect of polyanions on the refolding of human acidic fibroblast growth factor. (1991)

Acidic fibroblast growth factor (aFGF) is unstable at physiological temperatures in the absence of polyanions such as heparin. Therefore, the effect of temperature on the kinetics of refolding of aFGF has been examined in the presence and absence of several polyanions. The protein folds into its native state at temperatures up to 30 degrees C without polyanions with an activation energy of approximately 14 kcal/mol, but does not acquire native structure above this temperature. When heparin, inositol hexasulfate, or sulfate ion are present, aFGF refolds below 30 degrees C with a slightly reduced activation energy (10-11 kcal/mol). In addition, the protein now also renatures between 30 and 50 degrees C with activation energies of 1-2 (heparin), 16 (inositol hexasulfate), and 7 (sulfate) kcal/mol. Trace heavy metals appear to inhibit the refolding process, but a molecular chaperone (bovine 70-kDa heat shock cognate protein) and a peptidylprolyl isomerase (the FK506-binding protein) have no effect. It is concluded that the rate of refolding of aFGF at physiological temperatures is probably controlled by the interaction of a native-like state of the protein with an unknown polyanionic species.
Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot (2020)

With the growing interest in the optical imaging of ultrafast phenomena in transparent objects, from shock wave to neuronal action potentials, high contrast imaging at high frame rates has become desirable. While phase sensitivity provides the contrast, the frame rates and sequence depths are highly limited by the detectors. Here, we present phase-sensitive compressed ultrafast photography (pCUP) for single-shot real-time ultrafast imaging of transparent objects by combining the contrast of dark-field imaging with the speed and the sequence depth of CUP. By imaging the optical Kerr effect and shock wave propagation, we demonstrate that pCUP can image light-speed phase signals in a single shot with up to 350 frames captured at up to 1 trillion frames per second. We expect pCUP to be broadly used for a vast range of fundamental and applied sciences.
Fuzzy‐reasoning‐based computer‐aided diagnosis for automated discrimination of myocardial heart disease from ultrasonic images (2002)

Abstract This paper describes a fuzzy‐reasoning‐based computer‐aided diagnosis scheme for automated classification of cardiomyopathy from ultrasonic images. Unlike the conventional types of membership functions such as triangle and trapezoid, Gaussian‐distributed membership functions (GDMFs) are employed in the present study. The GDMFs are initially generated using various texture‐based features computed from gray‐level co‐occurrence matrices. Subsequently, the shapes of GDMFs are optimized by a genetic‐algorithm learning process. After optimization, the classifier is used to discriminate two sets of echocardiographic images, namely, normal and abnormal cases, which were diagnosed in advance by a highly trained physician. We experimentally evaluate the performance of the proposed method against various methods reported in terms of sensitivity, specificity, and total accuracy. Our results show the promise of the proposed approach in discriminating cardiomyopathy. © 2002 Wiley Periodicals, Inc. Electron Comm Jpn Pt 3, 85(11): 1–8, 2002; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecjc.10025
An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family. (1992)

In the present report we describe a CD4+8- heat stable antigen-negative (HSA-) thymocyte subpopulation that expresses a distinguishably low density of alpha beta T-cell antigen receptors (TCRlo) from the majority of CD4+8- high-density TCR (TCRhi) mature-type thymocytes. This subpopulation appears relatively late in life. Analysis of MEL-14, Pgp-1 (CD44), ICAM-1 (CD54), and NK1.1 expression on this subpopulation revealed that the CD4+8- TCRlo population was a population having unique characteristics (MEL-14-, CD44+, ICAM-1+, and NK1.1+) compared to the CD4+8- TCRhi thymocytes, most of which are MEL-14+, CD44-, ICAM-1-, and NK1.1-. When TCR beta-chain variable region (V beta) usage was analyzed, this thymic population expressed predominantly products of V beta 7 and V beta 8.2 TCR gene families. Interestingly, cells with V beta 8.1 TCRs, which are reactive to Mls-1a antigens, were not eliminated from the CD4+8- HSA- TCRlo subpopulation but had been eliminated from the major CD4+8- HSA- TCRhi subpopulation in Mls-1a strains. A subset with a phenotype similar to the CD4+8- HSA- TCRlo thymocytes was also identified primarily in bone marrow, and this subset constituted approximately half of the CD4+ T cells in the bone marrow. The CD4+8- HSA- TCRlo cells showed extremely high proliferative responses to immobilized anti-TCR antibody but generated negligible responses to allogeneic H-2 antigens compared to the responses generated by the major CD4+8- HSA- CD3hi cells. However, the CD4+8- HSA- TCRlo cells in Mls-1b mice mounted vigorous proliferative responses to Mls-1a antigens but not in Mls-1a mice. The properties of this T-cell subset suggest that these cells belong to a lineage distinct from the major T-cell population.
Analysis of Yeast Artificial Chromosome Clones (2003)

The technology of cloning large fragments of DNA in yeast as yeast artificial chromosomes (YACs) (1), combined with that of electro-phoretic separation of large fragments by pulsed-field gel electrophoresis (PFGE), has revolutionized research in molecular genetics. In addition to the large insert size, the YAC cloning system offers relatively unbiased genome representation compared to the conventional bacterial cloning systems based on plasmids or bacteriophages (2,3). The enormous impact of YAC cloning and PFGE techniques on physical mapping is being realized with the building of multimegabase contigs (contiguous cloned stretches of DNA). Some examples include mapping and cloning of a large gene like cystic fibrosis (CF) (4), of a chromosomal band like that of 18q21.3 (5), of a substantial portion of an entire human chromosome, Xq24-28 (3), and even an entire organism, C. eI.egum (2). Similarly, the use of YAC clones in the identification of disease-related genes like neurofibromatosis (NFl) is well documented (6). PFGE techniques play a major and critical role in the construction (see Chapter 16) and characterization (later in this chapter) of YAC clones.
THE TREATMENT OF ACNE VULGARIS WITH DAPSONE (1961)

Journal Article THE TREATMENT OF ACNE VULGARIS WITH DAPSONE Get access CYRIL M. ROSS, M.B., Ch.B., M.R.C.P., F.R.F.P.S. CYRIL M. ROSS, M.B., Ch.B., M.R.C.P., F.R.F.P.S. Dermatologist to the Boksburg‐Benoni and Far East Rand Hospitals Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 10, 1 October 1961, Pages 367–370, https://doi.org/10.1111/j.1365-2133.1961.tb14398.x Published: 01 October 1961
『동의보감(東醫寶鑑)』 오장육부(五臟六腑) 관련문(關聯門)의 처방(處方) 인용(引用)에 관한 고찰(考察) (2011)

Objective: One of the characteristics of ㅇ『Dongeuibogam』 is that there are citation records at the end of quotations. Therefore, each pharagraph and formula in 『Dongeuibogam』 has citation records. In this article, authors try to review on the way of those citation records. Method: Comparing citation records of formulae-names with citation records of formulae-explanations. Result: On one side, citation records of formulae-names and citation records of formulae-explanations are not same. Conclusion: There are no regular rules in the way of citation records in『Dongeuibogam』.
Immune combinational therapy targeting OX40 and IDO synergistically enhances efficacy of a cancer vaccine (2014)

Meeting abstracts Enhancing an effector immune response by cancer vaccines has not been clinically successful so far. Although the necessary immune response may be elicited using vaccine-based therapies, this has not been sufficient for a positive clinical outcome; since most cancers can escape
Genome Sequence of Staphylococcus aureus Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands (2007)

Strains of Staphylococcus aureus, an important human pathogen, display up to 20% variability in their genome sequence, and most sequence information is available for human clinical isolates that have not been subjected to genetic analysis of virulence attributes. S. aureus strain Newman, which was also isolated from a human infection, displays robust virulence properties in animal models of disease and has already been extensively analyzed for its molecular traits of staphylococcal pathogenesis. We report here the complete genome sequence of S. aureus Newman, which carries four integrated prophages, as well as two large pathogenicity islands. In agreement with the view that S. aureus Newman prophages contribute important properties to pathogenesis, fewer virulence factors are found outside of the prophages than for the highly virulent strain MW2. The absence of drug resistance genes reflects the general antibiotic-susceptible phenotype of S. aureus Newman. Phylogenetic analyses reveal clonal relationships between the staphylococcal strains Newman, COL, NCTC8325, and USA300 and a greater evolutionary distance to strains MRSA252, MW2, MSSA476, N315, Mu50, JH1, JH9, and RF122. However, polymorphism analysis of two large pathogenicity islands distributed among these strains shows that the two islands were acquired independently from the evolutionary pathway of the chromosomal backbones of staphylococcal genomes. Prophages and pathogenicity islands play central roles in S. aureus virulence and evolution.
Specijalne knjižnice i strategija razvoja (2013)

U radu se kroz rezultate ankete provedene 2011.godine upozorava na status specijalnih knjinica i knjiniara u matinim ustanovama
Intracerebral Transplantation of Marrow Stromal Cells Cultured with Neurotrophic Factors Promotes Functional Recovery in Adult Rats Subjected to Traumatic Brain Injury (2002)

This study was designed to examine the effects of bone marrow stromal cells (MSCs) cultured in vitro with or without neurotrophic factors transplanted into adult male Wistar rats after traumatic brain injury (TBI). MSCs harvested from donor Wistar rats were cultured with either the culture medium containing brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) or the same culture media without these factors. Control and experimental animals were then traumatized by a controlled cortical impact. One day after the impact, either the placebo or the washed MSCs (1 x 10(6)) cultured with or without NGF and BDNF were transplanted adjacent to the site of injury. In addition, a nontreated group of rats was employed. Motor function of the animals was evaluated by the Rotarod test both before and after the injury. All animals were sacrificed 8 days after TBI, and the brain sections were stained by H&E as well as for immunohistochemistry. MSCs survived and migrated toward the injury site. The group treated with MSCs cultured with BDNF and NGF had a significantly higher number of engrafted cells than the group treated with MSCs cultured without BDNF and NGF (6.3 x 10(4) +/- 4250 compared to 4.1 x 10(4) +/- 3684; p < 0.05). In both groups, some transplanted MSCs showed positive staining for astrocytic (GFAP) and neuronal markers (Neu N and MAP-2). The groups treated with MSCs had better motor function than the groups receiving no treatment or receiving the placebo (PBS; p < 0.05); however, the improvement reached statistical significance only in the group treated with MSCs cultured with neurotrophic factors. These data suggest that more robust motor function described in rats subjected to TBI and treated with intracerebral transplantation of MSCs was achieved by the use of MSCs cultured with neurotrophic factors.