gebhart/patrepeval huggingface dataset:
Meeting of Minds—Architect, Contractor, and Owner, The Subtle Process of Communication (2003)

The façade of any structure represents collaborative efforts by architect, owner and contractor. However, these efforts sometimes result in a less than successful project. A lack of understanding around process, individual roles and project expectations appears to be the culprit. The real question, how to change the outcome for greater success. I believe that one critically important ingredient is open and honest communication between owners, architects and contractors pertaining to project expectations, scope and final results. The architect is a pivotal partner, a first stringer with understanding of design, construction methods and processes. The architect is critical to the success of the overall project. How responsive should architects be to the owner? As a partner they should educate the owner as to best methods of project delivery, construction methods and contractors suitable to deliver a mutually satisfactory project. What role does the owner expect of the architect? Is it strictly design, project management, consulting, partnership, stakeholder, educator, employee or some combination? The owner's expectations of the architect vary by project, relationship and owners real understanding of the project. The owner and architect both require clear communications in expressing the needs and true expectations of the project. Once the owner and architect understand one another, they create a process incorporating project definition, scope, project specification and selection process toward soliciting a contractor to round out and expand the owner architect partnership. This newly formed relationship of owner, architect and contractor moves forward in a collaborative manner in which each individual contribution and success complements the overall project success. Let's examine the relationship between owner, architect and contractor relative to Exterior Building Walls in obtaining maximum efficiencies, durability and longevity by improving communications from beginning to end of the project.
A New Medicare Part B Wound Care Policy (2001)

Skin and wound care specialists should design an assessment tool that includes all the documentation required to prove medical necessity for the initial and continued use of NPWT, when appropriate for patients who are managing their wounds at home. In addition, specialists should supply the physician with the order form that is provided by the NPWT pump supplier. Finally, personnel should be trained to appropriately assess and document the need for NPWT. Once a Medicare Part B-covered patient at home qualifies for a NPWT pump and supplies, the supplier will deliver the equipment and supplies and will bill Medicare Part B directly. Payment will be 80% of the DMERC Fee Schedule. The patient will be charged 20% of the Medicare allowable fee.
Corridor Selection Under Semantic Uncertainty for Autonomous Road Vehicles (2018)

Automated driving systems are likely to encounter situations in which their understanding of the road is uncertain. State-of-the-art systems only act on a single road hypothesis. If that hypothesis is incorrect, the likely consequence is an undesired behavior of the automated vehicle. This paper shows that the consideration of multiple road hypotheses in the selection of a driving corridor can improve the performance of an automated driving system and relax the requirements on its perception system. Two algorithms are presented that infer a corridor from a multi-hypothesis road representation with respect to different navigational goals.
Peptide and Protein Hormones: Structure, Regulation, Activity A Reference Manual (1993)

Gonadoliberin parathyroid hormone and the calcitonin family corticoliberin - pro-opiomelanocortin cascade blood-pressure regulatory peptides cholecystokinin (CCK) and gastrin (GT) the secretin family neurotensin (NT) motilin (MT) pancreatic spasmolytic peptide (PSP).
Wolffish antifreeze protein genes are primarily organized as tandem repeats that each contain two genes in inverted orientation. (1988)

The antifreeze protein genes of the wolffish (Anarhichas lupus) constitute a large multigene family of 80 to 85 copies, which can be classified into two sets. One-third of the genes were linked but irregularly spaced. The other two-thirds were organized as 8-kilobase-pair (kbp) tandem direct repeats that each contained two genes in inverted orientation; DNA sequence analysis suggests that both genes are functional. Except for a single region specific to each gene, the genes and their immediate flanking sequences were 99.2% identical. This degree of identity ended soon after a putative transcription termination sequence; as the 3' ends of the genes were only 1.3 kbp apart, these sequences might confer mutual protection from interference by transcriptional runoff. A Southern blot of wolffish DNA restricted with enzymes that do not cut within the tandem repeats indicated that the repeats were clustered in groups of six or more. The organization of antifreeze protein genes in the wolffish was very similar to that in the unrelated winter flounder, which produces a completely different antifreeze. This similarity might reflect common dynamics by which their progenitors adapted to life in ice-laden sea water.
Metastable ultrathin crystal in thermally grown SiO2 film on Si substrate (2012)

A silicon dioxide film on a silicon substrate is the most essential element in semiconductor devices and various advanced materials. We have elucidated the atomic structure of SiO2 films using low-dose scanning transmission electron microscopy (STEM). We have visualized a metastable crystalline SiO2 layer near a silicon substrate, which was not revealed in previous studies probably due to the vitrification caused by electron irradiation. Our experimental results also suggest a crystallographic nature of various surface oxides.
Immunoaffinity Depletion of High Abundance Plasma and Serum Proteins (2009)

Analysis of human serum and plasma has been a major focus of many recent proteomics studies because blood is a promising, routinely collected biological fluid that is likely to contain multiple novel biomarkers for many human diseases, such as cancers and cardiovascular disease (1). Most cells in the body are thought to secrete or shed proteins into the blood, and therefore plasma is very likely to contain information concerning the physiological status of all tissues and organs in the body (2–4). While serum and plasma hold great potential as sources of new disease biomarkers, systematic discovery of novel biomarkers in patient cohorts is greatly complicated by the presence of a small number of highly abundant (mg/ml range) proteins in blood (2–6). In particular, serum albumin constitutes about 65% of total serum protein, while immunoglobulins contribute an additional 15%. Most of the remaining 20% of total protein content is comprised of a modest number of additional high- and medium-abundance (μg/ml range) proteins, which tend to obstruct discovery of novel, specific disease biomarkers present at ng/ml to pg/ml levels.
Design of fractional delay filters using convex optimization (2002)

Fractional sample delay (FD) filters are useful and necessary in many applications, such as the accurate steering of acoustic arrays, delay lines for physical models of musical instruments, and time delay estimation. This paper addresses the design of finite impulse response (FIR) FD filters. The problem is posed as a convex optimization problem in which the maximum modulus of the complex error is minimized. Several design examples are presented, along with an empirical formula for the filter order required to meet a given worst case group delay error specification.
Nerve growth factor in the synovial fluid of patients with chronic arthritis (1992)

Cytokines regulate nerve growth factor (NGF) synthesis during inflammatory processes. Since cytokines are also involved in the inflammatory processes of autoimmune rheumatic diseases, we examined levels of NGF in patients with rheumatoid or other types of chronic arthritis. NGF was present in the synovial fluid and synovium of patients with chronic arthritis, but was undetectable in control fluids. We conclude that NGF might be involved in the pathogenesis of arthritis.
Colloidal Microcapsules: Self‐Assembly of Nanoparticles at the Liquid–Liquid Interface (2010)

Colloidal microcapsules (MCs) are highly modular, inherently multiscale constructs of capsules stabilized by nano-/microparticle shells, with applications in many areas of materials and biological sciences, such as drug delivery, encapsulation, and microreactors. Until recently, fabrication of colloidal MCs focused on the use of submicron-sized particles because the smaller nanoparticles (NPs) are inherently unstable at the interface owing to thermal disorder. However, stable microcapsules can now be obtained by tuning the interactions between the nanometer-sized building blocks at the liquid-liquid interface. This Review highlights recent developments in the fabrication of colloidal MCs using NPs.
Acquired resistance of lung adenocarcinoma to EGFR-tyrosine kinase inhibitors gefitinib and erlotinib (2010)

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, are the first targeted therapy drugs approved for the treatment of advanced non-small-cell lung cancer (NSCLC). Interestingly, treatment with these small molecule, reversible EGFR-TKIs leads to more positive response rates in patients with adenocarcinoma, in females, Asians, and patients with no history of smoking. Positive responses to treatment in these populations may be due to the increased prevalence of mutations in the EGFR gene. Several distinct mutations in the EGFR gene have been identified in specimens from patients with NSCLC who responded to treatment with anilinoquinazoline EGFR inhibitors. However, despite the dramatic initial response to TKIs, most lung cancer patients relapse and subsequently become resistant to the drug, a process termed acquired resistance. The precise mechanisms underlying acquired resistance remain unclear. Resistance to EGFR-TKIs could result from several potential mechanisms, including development of a secondary mutation in EGFR (such as T790M), amplification of the MET receptor tyrosine kinase gene, or overexpression of other receptor tyrosine kinases.
Inducing High-Level Behaviors from Problem-Solving Traces Using Machine-Learning Tools (2007)

This article applies machine-learning techniques to student modeling, presenting a method for discovering high-level student behaviors from a very large set of low-level traces corresponding to problem-solving actions in a learning environment. The system encodes basic actions into sets of domain-dependent attribute-value patterns. Then, a domain-independent hierarchical clustering identifies high-level abilities, yielding natural-language diagnoses for teachers. The method can be applied to individual students or to entire groups, such as a class. The system was applied to the actions of thousands of students in the domain of algebraic transformations. This article is part of a special issue on intelligent educational systems.
Biological performance of a new β‐TCP/PLLA composite material for applications in spine surgery: In vitro and in vivo studies (2006)

The objective of this research was to carry out an in vitro and in vivo study of the biological performance of PLLA/beta-TCP composite materials, to estimate the scope of their potential applications in bone surgery. Samples with increasing beta-TCP (0-60% w/w) contents were processed by injection molding. The in vitro study consisted of an evaluation of inflammatory potential by assaying the IL-1alpha secreted by monocytes, and then cell proliferation (counting) and phenotype expression (PAL and I collagen) in human osteogenous cells. The in vivo study was carried out using cylindrical implants of composite materials composed of composite materials containing 0 or 60% beta-TCP and pure beta-TCP, respectively. The implants were inserted in femoral sites in rabbits, using the Kathagen protocol. Each animal received a 60% implant, with either a 0 or a 100% implant in the contralateral femur, so that the materials could be compared with one another. Five animals were examined for each material and implantation period, giving a total of 30 animals. This study showed that adding increasing percentages of beta-TCP to a lactic acid polymer matrix stimulated the proliferation of human osteogenous cells and synthesis of the extracellular bone matrix in a dose-dependent manner. In vivo results indicate that, in comparison with pure PLA, tricalcium phosphate-containing composite materials had faster degradation kinetics, caused less inflammatory reaction, and promoted contact osteogenesis. The composite material containing 60% beta-TCP demonstrated a similar performance to pure tricalcium phosphate bone grafts in terms of osteogenesis, and is apparently compatible with the production of intra-osseous implants for situations representing high levels of mechanical strain.
pathophysiology-of-blood-disorders (2010)

Pathophysiology of Blood Disorders , Pathophysiology of Blood Disorders , کتابخانه الکترونیک و دیجیتال - آذرسا
Rituximab Maintenance Therapy After Autologous Stem-Cell Transplantation in Patients With Relapsed CD20+ Diffuse Large B-Cell Lymphoma: Final Analysis of the Collaborative Trial in Relapsed Aggressive Lymphoma (2012)

In relapsed DLBCL, we observed no difference between the control group and the rituximab maintenance group and do not recommend rituximab after ASCT.
Muscarinic Induction of Synchronous Population Activity in the Entorhinal Cortex (1997)

Oscillation and synchronization of neural activity is important in normal brain function but is also relevant to epileptogenesis. One of the most frequent forms of epilepsy originates in temporal lobe circuitry of which the entorhinal cortex (EC) is crucial. Because muscarinic receptor activation promotes oscillatory dynamics in EC neurons, we investigated in a brain slice preparation the effects of carbachol (CCh) on oscillatory population activity in the EC. We found that CCh produced epileptiform activity in EC, which according to field profile and current source density analysis was usually driven by layer V. In addition, localized CCh application and surgical isolation experiments demonstrated that EC layer II, but not layer III, can also independently generate synchronous population activity. Intracellular recordings from EC principal cells during epileptiform activity demonstrated large-amplitude, synaptically driven depolarizing events and bursts of action potentials synchronized to the field spikes. In layer II neurons, the depolarizing events had a multiphasic reversal potential that suggested concurrent glutamatergic and GABAergic synaptic input. Interestingly, although the epileptiform activity required activation of AMPA but not NMDA receptors, small-amplitude field spikes persisted during block of fast excitatory neurotransmission. These field spikes were correlated to large-amplitude IPSPs in layer II neurons, and both activities were abolished by GABAA-receptor antagonism. Thus, in response to muscarinic activation, pools of EC interneurons discharge synchronously by a mechanism not necessarily involving principal cell activation. Given the differential projection pattern of EC layers V and II toward the neocortex and hippocampus, respectively, their robust epileptogenic character may be of major importance in temporal lobe epilepsy.
Normolipidemic Subjects With Low HDL Cholesterol Levels Have Altered HDL Subpopulations (1997)

Epidemiological studies have established that plasma concentration of HDL is inversely correlated with the risk of coronary heart disease, even in the absence of increased LDL cholesterol levels. We postulate that specific HDL subpopulations may be responsible for antiatherogenic properties of HDL. HDL subpopulations were quantitated by two-dimensional gel electrophoresis in 79 normolipidemic healthy male subjects. To eliminate the influence of diet, volunteers consumed an average American diet for 6 weeks. After the diet period, subjects were stratified according to their HDL cholesterol (HDL-C) levels to low HDL-C < 0.91 mmol/L (< 35 mg/dL), medium > 0.91 < 1.30 mmol/L (> 35 < 50 mg/dL), and high > or = 1.30 mmol/L (> or = 50 mg/dL) groups. Plasma triglycerides and insulin levels were in the normal range, but subjects with low HDL-C levels had higher concentrations of plasma triglycerides and insulin than subjects with medium or high HDL-C concentrations. The absolute concentration (mg/dL) of apoA-I in the largest alpha-migrating HDL subpopulation (alpha 1) was (P < .01) lower in the low HDL-C subjects compared with the medium and high HDL-C groups. The relative concentration (percent distribution) of apoA-I was decreased (P < .01) in alpha 1 and increased (P < .01) in alpha 3 subpopulations. A positive correlation between HDL-C and alpha 1 (P < .001) and a negative correlation between HDL-C and alpha 3 were observed. The inverse correlation of apoA-I distribution (relative concentration) between alpha 1 and alpha 3 suggests an interconversion of alpha 1 and alpha 3 subpopulations, possibly by cholesteryl ester transfer protein. Pre-beta subpopulations showed an inverse trend with HDL-C, while the pre-alpha subpopulation behaved similarly to the alpha-migrating subpopulation. Colocalization of apoA-I and apoA-II particles in the different HDL subpopulations demonstrated that alpha 1, pre-beta 1, and pre-beta 2 subpopulations are apoA-I-only particles rather than apoA-I:A-II particles.
Near-Infrared Fourier-Transform Raman Spectroscopy of Flax (Linum usitatissimum L.) Stems (1998)

Samples of flax (Linum usitatissimum L.) stem and its anatomical parts were studied by near-infrared Fourier transform Raman (NIR-FT-Raman) spectroscopy to determine if the major chemical components of each could be detected by this method. The Raman spectra of reference compounds from relatively pure materials served as models for the chemical components. Bands for cellulose were greatest in the fibers. Hemicellulosic polysaccharides were observed to be prevalent in bast tissue and fibers. Weak signals for pectins were observed in the bast, cuticle/epidermis, fibers, and stem. Bands for aromatic rings were detectable in all materials. Bands from waxes/fatty acid esters were detectable in the cuticle/epidermal tissue. The results indicated that NIR-FT-Raman could be used detect the major chemical components in flax in situ and provide a simple, rapid, and noninvasive assessment of their relative amounts and location within the tissues of the flax plant. Keywords: Fourier transform; Raman; flax; carbohydrates; phenolics; wax; fiber; bast; core; cuticle; epidermis
Recyclable Silica-Supported Iridium Bipyridine Catalyst for Aromatic C–H Borylation (2014)

A mesoporous silica (SBA-15)-supported bipyridine iridium complex is prepared by grafting of bipyridine onto the silica support, followed by complexation of an iridium(I) precursor in the presence of HBpin and cyclooctene. Structural analyses by X-ray powder diffraction, nitrogen physisorption, FT-IR, and solid-state NMR spectroscopy demonstrate that the 3-dimensional, hexagonal pore structure of SBA-15 is maintained after the immobilization. In particular, as a heterogeneous catalyst, this silica-supported iridium complex shows moderate to good catalytic activity in the aromatic C–H borylation of a variety of substrates. More importantly, the heterogeneous catalyst is recovered easily and reused repeatedly by simple washing without chemical treatment and exhibits good recycling performance with a modest decrease in the catalytic rate, showing good potential for increasing the overall turnover number of this synthetically useful catalyst.
Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction (2016)

CRISPR/Cas enhanced correction of the sickle cell disease (SCD) genetic defect in patient-specific induced Pluripotent Stem Cells (iPSCs) provides a potential gene therapy for this debilitating disease. An advantage of this approach is that corrected iPSCs that are free of off-target modifications can be identified before differentiating the cells into hematopoietic progenitors for transplantation. In order for this approach to be practical, iPSC generation must be rapid and efficient. Therefore, we developed a novel helper-dependent adenovirus/Epstein-Barr virus (HDAd/EBV) hybrid reprogramming vector, rCLAE-R6, that delivers six reprogramming factors episomally. HDAd/EBV transduction of keratinocytes from SCD patients resulted in footprint-free iPSCs with high efficiency. Subsequently, the sickle mutation was corrected by delivering CRISPR/Cas9 with adenovirus followed by nucleoporation with a 70 nt single-stranded oligodeoxynucleotide (ssODN) correction template. Correction efficiencies of up to 67.9% (β(A)/[β(S)+β(A)]) were obtained. Whole-genome sequencing (WGS) of corrected iPSC lines demonstrated no CRISPR/Cas modifications in 1467 potential off-target sites and no modifications in tumor suppressor genes or other genes associated with pathologies. These results demonstrate that adenoviral delivery of reprogramming factors and CRISPR/Cas provides a rapid and efficient method of deriving gene-corrected, patient-specific iPSCs for therapeutic applications.
Effect of buccal dwell time on the pharmacokinetic profile of fentanyl buccal tablet (2007)

The pharmacokinetic parameters of FBT did not appear to be related to its buccal dwell time.
这不是游戏 风险管理还是预防措施：叫什么名字重要吗？ (2016)

ISO 9001：2015中关于风险的内容引起两种不同的观点： 一部分人认为基于风险的思想是全新的内容，还从来没有在ISO9001中被提及。另一部分人则认为基于风险的思想原来一直都有，只是取代了预防措施出现在新版上。
A new reagent for the removal of the 4-methoxybenzyl ether: application to the synthesis of unusual macrocyclic and bolaform phosphatidylcholines. (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new reagent for the removal of the 4-methoxybenzyl ether: application to the synthesis of unusual macrocyclic and bolaform phosphatidylcholines.Normand Hebert, Alain Beck, R. Bruce Lennox, and George JustCite this: J. Org. Chem. 1992, 57, 6, 1777–1783Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/jo00032a033https://doi.org/10.1021/jo00032a033research-articleACS PublicationsRequest reuse permissionsArticle Views1519Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts