gebhart/patrepeval huggingface dataset:
Polygonization of non-manifold implicit surfaces (1995)

Article Polygonization of non-manifold implicit surfaces Share on Authors: Jules Bloomenthal Department of Computer Science, The University of Calgary Department of Computer Science, The University of CalgaryView Profile , Keith Ferguson Department of Computer Science, The University of Calgary Department of Computer Science, The University of CalgaryView Profile Authors Info & Claims SIGGRAPH '95: Proceedings of the 22nd annual conference on Computer graphics and interactive techniquesSeptember 1995 Pages 309–316https://doi.org/10.1145/218380.218462Published:15 September 1995 54citation775DownloadsMetricsTotal Citations54Total Downloads775Last 12 Months14Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Accuracy of Clinical Evaluation in Pediatric Obstructive Sleep Apnea (1998)

Eighty-two children underwent polysomnography (PSG) for symptoms suggestive of obstructive sleep apnea (OSA). Symptoms reported included snoring, witnessed apneic episodes, daytime somnolence, mouth breathing, and enuresis. Tonsillar size, nasal airway patency, and percentile weight were recorded. OSA was diagnosed on PSG when obstructive events were noted and apnea + hypopnea index was five or more per hour. The overall predictive accuracy of clinical suspicion of OSA was 25 (30%) of 82. Predictive accuracies (as a percentage of those with symptoms/signs who have OSA) and prevalences (as a percentage of those with OSA who have the symptom/sign), respectively, were for moderate snoring 29% (12 of 41), 48%; loud snoring 31% (11 of 35), 44%; witnessed apneas 32% (22 of 69), 88%; enuresis 46% (11 of 24), 44%; 2+ tonsillar size 37% (21 of 57), 84%; 3+ tonsillar size 33% (3 of 9), 12%; 90th percentile weight or greater 26% (7 of 27), 28%; 10th percentile weight or less 33% (5 of 15), 20%. Multiple regression analysis did not reveal a significant association between clinical parameters and the presence of OSA as defined by PSG.
Flow NMR spectroscopy in drug discovery. (2000)

Flow NMR spectroscopy techniques are becoming increasingly utilized in drug discovery and development. LC-NMR has become a routine method to resolve and identify mixture components. It has broad applications in natural products biochemistry, and drug metabolism and toxicology studies. The rapid throughput of direct-injection NMR of biofluids, combinatorial chemistry samples and protein/small molecule mixtures positions NMR spectroscopy to impact metabonomics, medicinal chemistry and protein screening. The concomitant development of robust automated data analysis tools has facilitated interpretation of the vast amount of NMR data generated.
Composites of Intrinsically Conducting Polymers as Sensing Nanomaterials (2008)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComposites of Intrinsically Conducting Polymers as Sensing NanomaterialsDavid W. Hatchett and Mira JosowiczView Author Information Department of Chemistry, University of Nevada, Las Vegas, Nevada 89154-4003 and Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400 Cite this: Chem. Rev. 2008, 108, 2, 746–769Publication Date (Web):January 3, 2008Publication History Received10 August 2007Published online3 January 2008Published inissue 1 February 2008https://pubs.acs.org/doi/10.1021/cr068112hhttps://doi.org/10.1021/cr068112hresearch-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views11244Altmetric-Citations570LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Composites,Materials,Plastics,Polymers,Sensors Get e-Alerts
Drop in process control checkerboard test structure for efficient online process characterization and defect problem debugging (2002)

A novel diode-checkerboard test structure (DCTS) is presented to determine open circuit defects and short circuit defects as well as to investigate the 3D-influence of underlying topography. The arrangement of the DCTS in a standard boundary pad frame and the digital measuring procedure evaluate a fast and effective (efficient) online process characterization. The precise defect detection and localization facilitate an additional optical defect problem debugging.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Structure, Production and Function of Erythropoietin: Implications for Therapeutical Use in Cardiovascular Disease (2007)

Erythropoietin (EPO) is a 30,400 daltons glycoprotein, consisting of 165 amino acids produced mainly in the kidney and in the liver and regulating erythrocyitosis. It primarily acts on erythroid precursor cell at colony-forming units-erythroid stage inhibiting the apoptosis. EPO binds on a specific membrane receptor thereby activating at least three specific intracellular signaling pathways, such as phosphatidylinositol 3-kinase/ protein kinase B, Ras-mitogen-activated protein kinase and some members of the signal transducers and activators of transcription family. In addition to kidney and liver, EPO mRNA has been detected in other tissues; accordingly EPO receptor has been identified in several type of cells and recent reports have suggested new roles for EPO in non-haematopoietic tissues with a robust evidence for neuroprotective and cardioprotective activity. In different animal models, in vitro, in isolated perfused heart and in vivo, recombinant human erythropoietin protects heart from ischemia reperfusion injury and reduces myocardial damage. EPO tissue protective activity can be separated from erythropoietic activity. Molecules owing the first property but not the second one have been described. In patients with acute myocardial infarction serum EPO level correlates inversely with infarct size. Acute coronary syndrome, extracorporeal circulation and percutaneous coronary intervention are potential fields of application for tissue protective EPO activity to reduce myocardial damage, increase cardiac function ad improve outcome.
Facile, Template‐Free Synthesis of Stimuli‐Responsive Polymer Nanocapsules for Targeted Drug Delivery (2010)

Open Sesame! A synthetic approach to stimuli-responsive polymer nanocapsules has been developed. The reductively labile polymer nanocapsule allows for not only facile, noncovalent surface modification but also the release of encapsulated cargo in response to a predefined redox stimulus in an intracellular environment. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
THE USE OF MYOCYTES AS A MODEL FOR DEVELOPING SUCCESSFUL HEART PRESERVATION SOLUTIONS (1991)

The development of a successful method to preserve the heart for relatively long periods (24-48 hr) requires demonstrating successful orthotopic transplantation and long-term survival after preservation. There are, however, multiple variables that may affect the quality of heart preservation, and it is nearly impossible to systematically study all the variables in this complicated model. One model that may be useful to study how preservation parameters affect heart cell preservation is the isolated myocyte preparation. In this study myocytes were isolated from the rabbit heart and the effects of up to 24 hr cold storage on viability measured to determine if this would be a suitable preservation model. Myocytes were stored in various preservation solutions including; EuroCollins (EC), two cardioplegic solutions (Stanford [ST] and Bretschneider solution [HTK]) and the University of Wisconsin solution (UW) with or without the addition of polyethylene glycol. The viability of myocytes was judged by measuring the effects of preservation and rewarming after preservation on cellular morphology (percent rod-shaped cells), ATP concentration, and LDH release. Myocytes preserved in the cardioplegic solutions were least well preserved after 12 and 24 hr storage, as judged by the loss of rod-shaped morphology and lower ATP concentration. Preservation in EC resulted in a decrease in the percent rod-shaped cells after 12 hr and 24 hr storage that was greater than obtained in the UW solutions. The best preservation of myocyte morphology and highest content of ATP was obtained in myocytes stored in the UW solutions, especially those containing PEG. The myocyte model of heart preservation shows a loss of cell integrity that is related to the preservation solution (HTK greater than ST greater than EC greater than UW-PEG) and these results are similar to what has been shown in the past with other models of heart preservation. Thus the myocyte model appears to be a useful method to test how many preservation solutions and preservation variables affect heart cell metabolism. In the future, results from these types of studies may find use in developing improved heart preservation solutions for testing in the orthotopic transplant model.
Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitat (2010)

Effective prediction of future viral zoonoses requires an in-depth understanding of the heterologous viral population in key animal species that will likely serve as reservoir hosts or intermediates during the next viral epidemic. The importance of bats as natural hosts for several important viral zoonoses, including Ebola, Marburg, Nipah, Hendra, and rabies viruses and severe acute respiratory syndrome-coronavirus (SARS-CoV), has been established; however, the large viral population diversity (virome) of bats has been partially determined for only a few of the ∼1,200 bat species. To assess the virome of North American bats, we collected fecal, oral, urine, and tissue samples from individual bats captured at an abandoned railroad tunnel in Maryland that is cohabitated by 7 to 10 different bat species. Here, we present preliminary characterization of the virome of three common North American bat species, including big brown bats (Eptesicus fuscus), tricolored bats (Perimyotis subflavus), and little brown myotis (Myotis lucifugus). In samples derived from these bats, we identified viral sequences that were similar to at least three novel group 1 CoVs, large numbers of insect and plant virus sequences, and nearly full-length genomic sequences of two novel bacteriophages. These observations suggest that bats encounter and disseminate a large assortment of viruses capable of infecting many different animals, insects, and plants in nature.
Apolipoprotein E Interacts With Hepatitis C Virus Nonstructural Protein 5A and Determines Assembly of Infectious Particles (2009)

These results suggest that recruitment of apoE by NS5A is important for viral assembly and release of infectious viral particles. These findings have important implications for understanding the HCV life cycle and the development of novel antiviral strategies targeting HCV-lipoprotein interaction.
Ultraviolet Radiation Stress Triggers the Down-regulation of Essential Replication Factor Mcm10 (2010)

We report that upon UV radiation insult, mammalian cells specifically down-regulate Mcm10, a protein essential for the initiation and elongation phases of DNA replication. The levels of a majority of replication factors remain unaffected under this condition, implying that Mcm10 is a key node in the regulation of the replication machinery. High doses of ionizing gamma radiation and exposure to a combination of DNA-damaging chemicals do not decrease Mcm10 protein levels, demonstrating that Mcm10 down-regulation is triggered only by UV-specific damage. The decrease of Mcm10 protein levels is not caused by transcriptional inhibition or cleavage by apoptotic enzymes, but results from degradation by the 26 S proteasome. UV-triggered degradation of Mcm10 requires its linker or C-terminal domain. In addition, Mcm10 down-regulation is not limited to cells from a particular lineage. Therefore, our study reveals a mechanism by which mammalian cells effectively inhibit the replication machinery during stress to prevent it from drifting toward a catastrophic path of genomic instability.
Expression of Serine/Threonine Kinase Receptors during Ectopic Bone Formation Induced by Bone Morphogenetic Protein(BMP). (1994)

To understand the precise mechanism of bone formation induced by bone morphogenetic proteins (BMPs), it is important to elucidate the receptor system of BMPs. In this study, expression of mRNAs for serine/threonine kinase receptors, including BMP receptors, during ectopic bone formation induced by BMP, was investigated, and also the molecular cloning of rat BMP type IA receptor (BMPR-IA) was performed. Polymerase chain reaction (PCR)-based analysis revealed that mRNAs for BMP type IA and type IB receptors were expressed in the BMP-induced bone forming tissues throughout the stages tested and that mRNA for activin type IA receptor, which was shown to serve as a receptor for BMP as well, was also expressed. These results suggest that these three receptors play important roles for the ectopic bone formation induced by BMP. In addition, expression of mRNAs for TGF-beta type I and type II receptors and activin type IB and type II receptors was also detected in the BMP-implanted tissues, which suggested the possible involvement of TGF-betas and activins as ligands in the ectopic bone formation. The comparison of the rat BMPR-IA with the human and mouse counterparts showed high conservation among species. This finding suggests that BMPs may exert their effects through highly conserved pathway among species.
Pro- versus anti-inflammatory cytokines: myth or reality. (2001)

Inflammation is characterized by an interplay between pro- and anti-inflammatory cytokines. Cytokines are commonly classified in one or the other category: interleukin-1 (IL-1), tumor necrosis factor (TNF), gamma-interferon (IFN-gamma), IL-12, IL-18 and granulocyte-macrophage colony stimulating factor are well characterized as pro-inflammatory cytokines whereas IL4, IL-10, IL-13, IFN-alpha and transforming growth factor-beta are recognized as anti-inflammatory cytokines. In this review, we point out that this classification is far too simplistic and we provide numerous examples illustrating that a given cytokine may behave as a pro- as well as an anti-inflammatory cytokine. Indeed, the cytokine amount, the nature of the target cell, the nature of the activating signal, the nature of produced cytokines, the timing, the sequence of cytokine action and even the experimental model are parameters which greatly influence cytokine properties.
Characterization of the Acid-Labile Subunit of the Growth Hormone-Dependent Insulin-Like Growth Factor Binding Protein Complex* (1988)

The insulin-like growth factors (IGFs) circulate predominantly in a 150,000-dalton (150K) complex, the IGFbinding component of which appears to be an acid-stable 53K glycoprotein (BP-53). This study tested the hypothesis that an acid-labile subunit (ALS) reacts with the binding subunit to form the 150K complex. ALS activity was quantitated by the conversion of covalent BP-53-[125I]IGF-I tracer from about 60K to about 150K. DEAE-Sephadex chromatography of serum at pH 8.2 yielded separate peaks of 30–60K BP-53 immunoreactivity and 100–110K ALS which, when mixed, converted the BP- 53 to 150K. Whole serum also contained 100–110K ALS not complexed with BP-53. ALS was markedly acid labile, irreversibly losing activity below pH 4.5. In an assay involving competition between test substances and BP-53-IGF-I tracer in the reaction with partially purified ALS, serum samples, acidified to inactivate endogenous ALS, reacted with potencies proportional to their immunoreactive BP-53 content. Pure BP-53 alone was inactive, but after preincubation with IGF-I or IGF-II, competed with a potency identical to that of BP-53 in acidified serum. Amniotic fluid IGF-binding protein, with or without IGFs, had no activity. These results confirm that serum contains an acidlabile protein which interacts with the acid-stable IGF-binding protein BP-53, when it is occupied by IGFs, to convert it to the 150K form,
Two genes present on a transposon‐like structure in Lactococcus lactis are involved in a Clp‐family proteolytic activity (1993)

The lactose-protease plasmid pUCL22 of Lactococcus lactis subsp. lactis strain CNRZ270 contained two inverted copies of IS 1076 flanking a region of 3.7 kb. This internal region was sequenced and found to contain two large open reading frames, ORF1 and ORFP in opposite orientations. ORF1 consists of 2289 bp; the deduced 763-amino-acid sequence is similar to the ATPases of the ClpA family. It contains two well-conserved consensus ATP-binding sites. It was named ClpL. ORFP consists of 930 bp encoding a protein of 310 amino acids. No similarity with any known protein was found in GenBank data for ORFP. Increased ATP-dependent proteolytic activity was detected in extracts from Escherichia coli cells expressing the clpL and ORFP genes.
Potentielle Analgetika, 7. Mitt. Über die analgetische Wirksamkeit einiger reduzierter Biphenyl‐Mannich‐Basen (1976)

Abstract Die pharmakologische Prüfung einiger reduzierter Mannich ‐ Basen der Monoacyl‐biphenyl‐Reihe auf Toxizität und analgetische Wirksamkeit mit der Brennstrahl‐Methode wird beschrieben. Mit einer ED 50 von 15 mg/kg Maus besitzt 4‐(γ‐N‐Methyl‐2‐phenyläthylamino‐propanol)‐biphenyl ungefähr 1/4 der Wirkungsstärke des Morphins und mit einer therapeutischen Breite von 9,6 die beste Verträglichkeit der getesteten Verbindungen.
RELATIVE PERFORMANCE OF SINGLE CROSS, THREE-WAY CROSS, AND DOUBLE CROSS CORN HYBRIDS RECOMMENDED IN ONTARIO, 1968–72 (1973)

Yield performance was determined for all single cross (SC), three-way cross (3W), and double cross (DC) corn (Zea mays L.) hybrids recommended by the Ontario Corn Committee between 1968 and 1972. The SC hybrids yielded 3.8 q/ha more than 3W and 6.3 q/ha more than DC. The yield advantage of the SC was apparent over all heat unit areas and years. The SC outyielded 3W and DC in both high- and low-yielding environments. This yield advantage was proportionately greater at the high-yielding environments. Yield stability of the three groups is discussed. Stability is described by two parameters, a regression coefficient and the standard error of this regression. The regression coefficient is calculated by regressing over locations the mean yield of each group of hybrids, at each location on the mean yield of all hybrids at that location. There were no differences in yield stability between the three types of hybrids.
Mechanism of the Mesenchymal–Epithelial Transition and Its Relationship with Metastatic Tumor Formation (2011)

Cancer metastasis consists of a sequential series of events, and the epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are recognized as critical events for metastasis of carcinomas. A current area of focus is the histopathological similarity between primary and metastatic tumors, and MET at sites of metastases has been postulated to be part of the process of metastatic tumor formation. Here, we summarize accumulating evidence from experimental studies that directly supports the role of MET in cancer metastasis, and we analyze the main mechanisms that regulate MET or reverse EMT in carcinomas. Given the critical role of MET in metastatic tumor formation, the potential to effectively target the MET process at sites of metastasis offers new hope for inhibiting metastatic tumor formation.
POLICY OF PRIORITIZATION OF ACCESS TO STATIONS WITH DIFFERENTRATES FOR 802.11 NETWORKS BASED ON THE SNR (2008)

The IEEE 802.11 wireless local area network, the most used
					wireless standard in computers network, presents a MAC anomaly when
					stations with different bit rates are connected in the same Access
					Point. Stations with high SNR have worst performance than stations
					with low SNR. This condition is worse in PWLANs (Public Wireless
					Local Area Network) with users connecting with different bit rates.
					This paper proposes a policy that uses the SNR (Signal to Noise
					Rate) and the condition of propagation to control users Contention
					Window. With this policy it is possible to control the Bit Rate,
					which is not possible in the 802.11 networks.
Novel Risk Factors for Systemic Atherosclerosis (2001)

Of 11 atherothrombotic biomarkers assessed at baseline, the total cholesterol-HDL-C ratio and CRP were the strongest independent predictors of development of peripheral arterial disease. C-reactive protein provided additive prognostic information over standard lipid measures.
Applying multimedia to medical imaging (1996)

We present the architecture of MediaStation 5000 and its applications in medical imaging. As a medical imaging workstation, MediaStation 5000 satisfies the basic requirement of fast image display and processing. All the important image display, manipulation, and processing functions can be executed in real time on 512/spl times/512 images, providing instant feedback to the user.
An integrated method for evaluating interfaces (2001)

To take advantage of the interdisciplinary experience of our colleagues, we decided several years ago to add heuristic evaluation to our expert analysis method. Although heuristic evaluation is a cost-effective method for evaluating interfaces, we found that the recommended prioritization strategy--ranking the problems according to severity--has several limitations. Specifically, it does not address how much it will cost the developers to fix the problems, nor does it adequately capture the distinction between high-level (global) and low-level (specific, screen-level) problems. To address these limitations, we developed a method which retains the richness of heuristic evaluation, but communicates the results in such a way that project managers, developers, and designers can form a clear and immediately executable plan for addressing the problems. Our method integrates user research, heuristic evaluation, affinity diagramming, cost-benefit charts, and recommendations into a report that others can use to plan both short and long-term improvements.