gebhart/patrepeval huggingface dataset:
Multi-tenant access control for cloud services (2014)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi List of Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi List of Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xii Chapter 1: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Problem Statement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Scope and Assumptions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.4 Thesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.5 Summary of Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.6 Organization of the Dissertation . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Chapter 2: Related Work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.1 Centralized Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.2 Decentralized Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.3 Attribute-Based Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.4 Enforcement and Implementation . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Chapter 3: Multi-Tenant Access Control (MTAC) Models . . . . . . . . . . . . . . . . . 15 3.1 MTAS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3.1.1 Formalization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3.1.2 Administrative MTAS (AMTAS) Model . . . . . . . . . . . . . . . . . . . 21 3.1.3 Enhanced Trust Models . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Increased Mortality Associated With Cheyne-Stokes Respiration in Patients With Congestive Heart Failure (1996)

We hypothesized that mortality is higher in patients with congestive heart failure (CHF) who develop Cheyne-Stokes respiration (CSR) during sleep than CHF patients without CSR. Overnight polysomnography was performed on 16 male patients with chronic, stable CHF: nine had CSR during sleep (CSR group) and seven did not (CHF group). The CSR group had a higher apnea-hypopnea index (AHI: 41 +/- 17 versus 6 +/- 5/hr) and experienced greater sleep disruption. There were no significant intergroup differences between age, weight, cardiac function, and pulmonary function. After the initial sleep study, all patients were maintained on standard medical therapy for CHF without supplemental oxygen or nasal continuous positive airway pressure. Over the next 3.1 to 4.5 yr there was a significant difference between the number of deaths in each group. Five patients died in the CSR group and two received a heart transplant, whereas only one patient died in the CHF group. Regression analysis revealed that mortality was positively correlated with CSR, AHI, arousal index, and the amount of stage 1, 2 non-REM sleep and was inversely related to the total sleep time. We conclude that mortality is higher in CHF patients who develop CSR during sleep than CHF patients without CSR. Although the development of CSR may simply reflect more severe cardiac impairment, we suggest that CSR itself accelerates the deterioration in cardiac function.
New Biologic and Synthetic Vascular Prostheses (1991)

New biologic and synthetic vascular prostheses , New biologic and synthetic vascular prostheses , کتابخانه دیجیتال جندی شاپور اهواز
Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit (1988)

Patients with hepatic failure admitted to the medical ICU (MICU) generally have a poor prognosis. To determine if there were readily identifiable clinical factors associated with a high predictive value for outcome, we reviewed retrospectively the charts of 100 patients with serious liver disease admitted to the MICU. The overall mortality of the group was 64%. We found that Child's class, a need for mechanical ventilation, and an elevated serum creatinine had the greatest prognostic significance. Ninety-one percent of the patients receiving assisted ventilation, 89% of the patients in Child's class C, and 93% of the patients with creatinine values greater than 1.3 mg/dl died during their MICU admission. Furthermore, a multivariant regression analysis indicated that patients in Child's class C receiving mechanical ventilation who had an abnormal serum creatinine (greater than 1.3 mg/dl) during the first 72 h in the MICU had only a 2% survival rate.
Expanded Porphyrins: The Synthesis and Metal Binding Properties of Novel Tripyrrane-Containing Macrocycles (1988)

Abstract Novel tripyrrane macrocycles have been prepared by the Schiff base condensation of 2,5-bis-(3-ethyl-5-formyl-4-methyl-pyrrol-2-ylmethyl)-3,4-diethylpyrrole and simple diamines. The structurally characterized macrocycle 1 forms 1:1 complexes with both Rh(I) and Zn(II) cations in which the metal is coordinated only to the imine nitrogens. In the presence of Cd(II) and oxygen, however, compound 1 is oxidized to the aromatic pentadentate ‘expanded porphyrin’ macrocycle 5, into which the metal cation is fully complexed.
Stereocomplex formation between enantiomeric poly(lactic acid)s. 2. Stereocomplex formation in concentrated solutions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereocomplex formation between enantiomeric poly(lactic acid)s. 2. Stereocomplex formation in concentrated solutionsHideto Tsuji, Fumitaka Horii, Suong Hyu Hyon, and Yoshito IkadaCite this: Macromolecules 1991, 24, 10, 2719–2724Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://doi.org/10.1021/ma00010a013RIGHTS & PERMISSIONSArticle Views1484Altmetric-Citations199LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (616 KB) Get e-Alerts Get e-Alerts
Bacterial aptamers that selectively bind glutamine (2011)

The continued expansion of microbial sequence data has allowed for the detection of an increasing number of conserved RNA motifs by using comparative sequence analysis. Recently, we reported the discovery of two structured non-coding RNA motifs, called glnA and Downstream-peptide, that have similarity in sequence and secondary structure. In this report, we describe data demonstrating that representatives of both RNA motifs selectively bind the amino acid L-glutamine. These glutamine aptamers are found exclusively in cyanobacteria and marine metagenomic sequences, wherein several glnA RNA representatives reside upstream of genes involved in nitrogen metabolism. These motifs have genomic distributions that are consistent with a gene regulation function, suggesting they are components of glutamine-responsive riboswitches. Thus, our findings implicate glutamine as a regulator of cyanobacterial nitrogen metabolism pathways. Furthermore, our findings expand the collection of natural aptamer classes that bind amino acids to include glycine, lysine and glutamine.
Cytoprotective activity of Amla (Emblica ofﬁcinalis) against chromium (VI) induced oxidative injury in murine macrophages (2003)

The cytoprotective and immunomodulating properties of Emblica officinalis (Amla) against chromium (VI) induced oxidative damage are reported. Chromium (VI) at 1 micro g/mL concentration was highly cytotoxic. It enhanced free radical production and decreased reduced glutathione (GSH) levels and glutathione peroxidase (GPx) activity in macrophages. The presence of Amla resulted in an enhanced cell survival, decreased free radical production and higher antioxidant levels similar to that of control cells. Further, chromium (VI) treatment resulted in decreased phagocytosis and gamma-interferon (gamma-IFN) production while Amla inhibited chromium induced immunosuppression and restored both phagocytosis and gamma-IFN production by macrophages significantly.
Reflectance measurements of hematocrit and oxyhemoglobin saturation (1987)

Fiberoptic oximeters measure oxyhemoglobin saturation from the optical reflectance of whole blood, but the calibration of such oximeters is hematocrit dependent. Therefore, using photon-diffusion theory and an empirical approach, we have developed a new reflectance method that determines hematocrit and correspondingly corrects the oxyhemoglobin-saturation measurement. Our method employs four fiber-optic light guides, a photodetector, and three inexpensive light-emitting diodes (one with emissions at 660 nm and two at 813 nm). Hematocrit is determined from the ratio of reflectances from the differently spaced emitting fibers at 813 nm and is used to correct the 813-660 nm measurement of oxyhemoglobin saturation. In red cell suspensions, the mean difference between reflectance measurements of hematocrit and conventional determinations was only 2.09% (r = 0.99), and when compared with conventional gasometric measurements of oxyhemoglobin saturation, the reflectance method yielded the same calibration curve for different hematocrits and gave a mean difference of only 2.67%. Although the technique is demonstrated with a cuvette appropriate for an extracorporeal circulation in animal experiments, it could possibly be further developed for fiber-optic catheter oximeters.
Neurons Are Protected from Excitotoxic Death by p53 Antisense Oligonucleotides Delivered in Anionic Liposomes (2001)

The potential of anionic liposomes for oligonucleotide delivery was explored because the requirement for a net-positive charge on transfection-competent cationic liposome-DNA complexes is ambiguous. Liposomes composed of phosphatidylglycerol and phosphatidylcholine were monodisperse and encapsulated oligonucleotides with 40-60% efficiency. Ionic strength, bilayer charge density, and oligonucleotide chemistry influenced encapsulation. To demonstrate the biological efficacy of this vector, antisense oligonucleotides to p53 delivered in anionic liposomes were tested in an in vitro model of excitotoxicity. Exposure of hippocampal neurons to glutamate increased p53 protein expression 4-fold and decreased neuronal survival to approximately 35%. Treatment with 1 microm p53 antisense oligonucleotides in anionic liposomes prevented glutamate-induced up-regulation of p53 and increased neuronal survival to approximately 75%. Encapsulated phosphorothioate p53 antisense oligonucleotides were neuroprotective at 5-10-fold lower concentrations than when unencapsulated. Replacing the anionic lipid with phosphatidylserine significantly decreased neuroprotection. p53 antisense oligonucleotides complexed with cationic liposomes were ineffective. Neuroprotection by p53 antisense oligonucleotides in anionic liposomes was comparable with that by glutamate receptor antagonists and a chemical inhibitor of p53. Anionic liposomes were also capable of delivering plasmids and inducing transgene expression in neurons. Anionic liposome-mediated internalization of Cy3-labeled oligonucleotides by neurons and several other cell lines demonstrated the universal applicability of this vector.
Specific inhibition of human natural killer cell‐mediated cytotoxicity by sialic acid and sialo‐oligosaccharides (1986)

We have tried to identify carbohydrate structures involved in recognition and/or lysis of K562 target cells by human natural killer (NK) cells. Inhibition studies were performed with mono-, di- and trisaccharides, and with glycopeptides and glycoproteins of known carbohydrate composition. When tested with various monosaccharides, lysis of K562 cells was inhibited only by N-acetylneuraminic acid (NeuAc). Di- and trisaccharides and glycopeptides containing NeuAc or N-glycolylneuraminic acid (NeuGc) all inhibited NK cell-mediated lysis. Among the non-sialylated carbohydrates tested, only Gal beta(1----3)GalNAcol was effective. The inhibitory capacity of sialylated compounds appeared to be dependent on the linkage type of the sialic acid residue; carbohydrates containing alpha(2----6)-linked sialic acids were more potent inhibitors than their alpha(2----3) isomers. Also the sugar to which the sialic acid residue was attached was of importance, NeuAc alpha(2----6)GalNAcol being more effective than NeuAc alpha(2----6)Gal beta 1----R (where R = glucose or oligosaccharide-peptide). Sialylated compounds and free sialic acid had minor or no effects on cell-mediated cytotoxicity by allo-sensitized cytotoxic T lymphocytes. The conjugation of target cells and NK effector cells was not inhibited by carbohydrates that effectively blocked the cytolytic response. These results may indicate that cell-surface carbohydrates containing alpha(2----6)-linked sialic acid are crucial structures in a post-binding event in NK-cell-mediated lysis.
Theoretical framework to costruct optimal flight safety diagnostic procedures (2012)

The problem of reconstruction of the avionic equipment diagnostic procedures to meet the new challenges is discussed. After short review of the essentials of the modern Information and Optimal Control theories ways of their applications in the framework of proposed mathematical formalism are described.
Expression of the human insulin gene in an alternate mammalian cell and in cell extracts. (1983)

The functional regions of the human insulin gene have been characterized by in vitro and in vivo experiments. The locations of the insulin promoter and cap site have been predicted from the sequence of the gene, and these assignments are consistent with the results of in vitro transcription experiments using HeLa cell extracts. For studies of intracellular expression, the human insulin gene including its promoter and two intervening sequences was inserted into the late region of the virus, SV40, in a construction that eliminates the major splice junction of the late SV40 region. Permissive CV1 monkey kidney cells were infected with this recombinant and a complementing helper virus. During the course of the infection, insulin gene transcripts accumulate at about one-third the level of SV40 late transcripts originated from the same promoter. Analysis of the RNAs containing insulin sequences showed that the insulin introns are excised with precision. Furthermore, the insulin promoter (cap site) and polyadenylation sites are recognized but are less efficiently employed than the viral late promoter and terminator. The mRNA is translated and immunoreactive human proinsulin is secreted into the extracellular medium.
Disruption of the Fifth Melanocortin Receptor Alters the Urinary Excretion of Aggression-modifying Pheromones in Male House Mice (2002)

The preputial glands of house mice express the gene for the fifth melanocortin receptor (MC5-R) and are a primary source of urinary pheromones involved in inter-male aggression. A 'resident-intruder' behavioral model was used to compare the responses of resident males to urine from mice with an engineered disruption of the fifth melanocortin receptor (MC5-RKO) with residents' responses to urine from wild-type mice (WT). Each type of urine was presented in combination with a castrated intruder male to provide the appropriate biological context. Resident males responded with a longer latency to bite when the urine was from gonadally intact WT males compared with urine from MC5-RKO mice. These results are consistent with the hypothesis that activation of the fifth melanocortin receptor in the preputial glands of male house mice causes excretion of urinary pheromones that delay aggressive responses by other males.
Optimum design of n+-n-double-diffused drain MOSFET to reduce hot-carrier emission (1985)

Channel electric field reduction using an n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> double-diffused drain MOS transistor to suppress hot-carrier emission is investigated. The double-diffused structure consists of a deep low-concentration P region and a shallow high-concentration As region. The channel electric field strongly depends on such process and device parameters as the length of the n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> diffusion region, drain junction depth, gate oxide thickness, gate length, applied voltage, and P implant energy. The optimum condition for a double-diffused structure is determined based on those parameter dependences of the channel electric field. The results of the optimum drain impurity profile to give the minimum channel electric field are obtained when the maximum lateral electric field is located at the boundary between the P region and the As region. The hot-carrier immunity of MOSFET and test circuits are improved by two orders of magnitude and one order of magnitude, respectively, under the optimum conditions.
SoftTarget Regularization: An Effective Technique to Reduce Over-Fitting in Neural Networks (2017)

Deep neural networks are learning models with a very high capacity and therefore prone to over- fitting. Many regularization techniques such as Dropout, DropConnect, and weight decay all attempt to solve the problem of over-fitting by reducing the capacity of their respective models (Srivastava et al., 2014), (Wan et al., 2013), (Krogh & Hertz, 1992). In this paper we introduce a new form of regularization that guides the learning problem in a way that reduces over- fitting without sacrificing the capacity of the model. The mistakes that models make in early stages of training carry information about the learning problem. By adjusting the labels of the current epoch of training through a weighted average of the real labels, and an exponential average of the past soft-targets we achieved a regularization scheme as powerful as Dropout without necessarily reducing the capacity of the model, and simplified the complexity of the learning problem. SoftTarget regularization proved to be an effective tool in various neural network architectures.
Synthesis and cardioprotective properties of apelin-12 and its structural analogues (2012)

Apelin-12 and a number of its analogues (Nle10-, MeArg1, Nle10, MeArg1, Nle10, Phe12-NH2-, Arg1(NO2), Nle10, Phe12-NH2-), resistant to the degradation of proteases, were synthesized by the Fmocmethod of SPPS. By-products of synthesis were examined. It was found that the serine hydroxyl group was sulfating during the final deprotection of apelin-12 and its analogues. The sulfate moiety of the Arg-protecting group transfers into the hydroxyl group of Ser. The amount of by-product depends on the water presence in cleavage mixture. Furthermore, the final deprotection of amide analogues of apelin-12 was accompanied by the formation of a by-product — 4-hydroxybenzylamide; its amount ranged from 20% to 8% in the reaction mixture (according to HPLC data) and also depended on the composition of the cleavage mixture. Effects of the synthesized peptides on recovery of the cardiac function after ischemia were examined in a model of isolated perfused rat heart. Infusions of any of the peptides (I–V) before ischemia resulted in a significant improvement of contractile and pump function recovery compared with the control. Cardioprotective efficacy of the peptides increased in the following rank (I) < (II) = (III) < (IV) = (V).
Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma (1997)

Recently, major advances have been made in the identification of antigens from human melanoma which are recognized by T cells. In spite of this, little is known about the optimal ways to use these antigens to treat patients with cancer. Progress in this area is likely to require accurate preclinical animal models, but the availability of such models has lagged behind developments in human tumor immunology. Whereas many of the identified human melanoma antigens are normal tissue differentiation proteins, analogous murine tumor antigens have not yet been identified. In this paper we identify a normal tissue differentiation antigen, tyrosinase-related protein 2 (TRP-2), expressed by the murine B16 melanoma which was found by screening a cDNA library from B16 with tumor-reactive cytotoxic T lymphocytes (CTL). A peptide conforming to the predicted MHC class I H2-Kb binding motif, TRP-2181-188, was identified as the major reactive epitope within TRP-2 recognized by these anti-B16 CTLs. By site-directed mutagenesis, it was shown that alteration of this epitope eliminated recognition of TRP-2. It was further demonstrated that a CTL line raised from splenocytes by repeated stimulation in vitro with this peptide could recognize B16 tumor and was therapeutic against 3-d-old established pulmonary metastases. The use of TRP-2 in a preclinical model of tumor immunotherapy may be helpful in suggesting optimal vaccination strategies for cancer therapy in patients.
Observation of the Rayleigh-Plateau Instability in the Core of a Multi-material Optical Fiber during Tapering (2010)

We study experimentally and theoretically the limits on size reduction of features in a multi-material optical fiber. We find that the Rayleigh-Plateau instability sets the minimum transverse size of an axially continuous feature.
Stereoselective Nucleophilic Trifluoromethylation of N-(tert-Butylsulfinyl)imines by Using Trimethyl(trifluoromethyl)silane Support of our work by Loker Hydrocarbon Research Institute is gratefully acknowledged. (2001)

A very general reaction is presented to achieve the nucleophilic transfer of "CF<sub>3</sub> " to chiral N-(tert-butylsulfinyl)imines in high yield and high stereoselectivity. Tetrabutylammonium difluorotriphenylsilicate (TBAT) functions as a fluoride source, and aromatic, heterocyclic, and aliphatic sulfinylimines react smoothly. The high stereoselectivity suggests that the reaction proceeds through an open transition state. TMS=trimethylsilyl.
Automated multiple peptide synthesis. (1993)

A fully automated instrument for multiple simultaneous peptide synthesis was constructed to provide large numbers of peptides for immunological research. The synthesis is performed in a flow-through mode with the conventional solid supports contained in 48 individual reaction columns. The instrument is based on a commercial autosampler equipped with a motor-driven syringe for accurate delivery of reagents and a robot arm carrying a dispenser needle. Dedicated software was developed to compile overlapping peptides from a given protein sequence and to control all functions of the robot. In situ activation by BOP was chosen as the optimized chemistry protocol. The peptides are cleaved from the resin in the reactors used for synthesis, thus minimizing handling. Performance of the instrument was demonstrated by synthesis of overlapping 14-mer peptides derived from the sequence of HIV reversed transcriptase. A second mode of operation allows the synthesis to be carried out on the surface of polyethylene pins. Peptides derived from the sequence of human TNF were synthesized using this method and used to characterize antibodies raised against the intact protein.