INFLUENZA: THE NEWE ACQUAYANTANCE (1953)

Article1 August 1953INFLUENZA: THE NEWE ACQUAYANTANCETHOMAS FRANCIS JR., M.D.THOMAS FRANCIS JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-2-203 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe honor conferred by The American College of Physicians in naming me the James D. Bruce Memorial Lecturer in Preventive Medicine for 1953, I fully appreciate. The atmosphere in which I grew up medically, though primarily concerned with the care of the patient, constantly stimulated an interest in the broader problem of the disease itself and the biologic mechanisms involved in its occurrence. There was the hopeful attitude that not only could understanding be gained but also that it could lead to better treatment of the sick and, still further, to the ultimate objective—prevention. It was not a pattern of...Bibliography1. Editorial: Glimpses of influenza in the past, Brit. M. J. 1: 138, 1919. Google Scholar2. Thompson T: Annals of influenza, 1852, The Sydenham Society, London. (a) p. 11, Willis: Epidemic of 1658. (b) pp. 6-10, Short, T.: Epidemics of 1510-1581. (c) p. 60, Hoxham: Epidemic of 1743. (d) p. 66, Alves, J.: Letter to Dr. Robert Whytt, 1759. (e) pp. 117-148, Gray, E.: The epidemic catarrh of 1782; p. 170, Hamilton, R.: Age and constitution most liable to the influenza (1782); p. 149, Smyth, C.: Account of influenza, London, 1782. (f) p. 302, Streeten, R. J. N.: Epidemic catarrh of 1836-37. Google Scholar3. ThomsonR. D: Influenza, Vol. 9, 1933, Butterworth, London. Google Scholar4. Jordan EO: Epidemic influenza, 1927, American Medical Association, Chicago. (a) p. 12. (b) pp. 18-19. Google Scholar5. Hirsch A: Handbook of geographical and historical pathology, 2nd Ed., trans, from German by Charles Creighton, Vol. I, 1883, The New Sydenham Society, London. Google Scholar6. CollinsFrostGoverSydenstricker SDNHME (a) : Mortality from influenza and pneumonia in 50 large cities of the United States, 1910-1929, Pub. Health Rep. 45: 2277, 1930. (b) Collins, S. D.: Influenza and pneumonia excess mortality at specific ages in the epidemic of 1943-44, with comparative data for preceding epidemics, Pub. Health Rep. 60: 821, 853, 1945. CrossrefMedlineGoogle Scholar7. FrancisQuilliganMinuse TJJE: Identification of another epidemic respiratory disease, Science 112: 495, 1950. CrossrefMedlineGoogle Scholar8. Francis T: The development of the 1943 vaccination study of the Commission on Influenza, Am. J. Hyg. 42: 1, 1945. Google Scholar9. FrancisSalkBrace TJEWM: The protective effect of vaccination against epidemic influenza B, J. A. M. A. 131: 275, 1946. CrossrefMedlineGoogle Scholar10. Frost WH (a) : Statistics of influenza morbidity, with special references to certain factors in case incidence and case fatality, Pub. Health Rep. 35: 584, 1920. (b) Frost, W. H., and Sydenstricker, E.: Influenza in Maryland—preliminary statistics on certain localities, Pub. Health Rep. 34: 491, 1919. CrossrefGoogle Scholar11. Collins SD (a) : Age and sex incidence of influenza and pneumonia morbidity and mortality in the epidemic of 1928-29 with comparative data for the epidemic of 1918-19. Based on surveys of families in certain localities in the United States following epidemics, Pub. Health Rep. 46: 1909, 1931. (b) Collins, S. D.: The influenza epidemic of 1928-29 in 14 surveyed localities in the United States. An analysis according to age, sex and color of the records of morbidity and mortality obtained in the surveys, Pub. Health Rep. 49: 1, 1934. (c) Collins, S. D.: Age and sex incidence of influenza in the epidemic of 1943-44 with comparative data for preceding outbreaks. Based on surveys in Baltimore and other communities in the Eastern States, Pub. Health Rep. 59: 1483, 1944. (d) Collins, S. D., and Lehmann, J.: Trends and epidemics of influenza and pneumonia, Pub. Health Rep. 66: 1487, 1951. CrossrefMedlineGoogle Scholar12. Francis T: Epidemiological studies in influenza, Am. J. Pub. Health 27: 211, 1937. CrossrefGoogle Scholar13. Heffron R: Accessory factors influencing incidence of pneumonia, in Pneumonia, 1939, Commonwealth Fund, New York, pp. 299-307. Google Scholar14. WinternitzWasonMcNamara MCIMFP: Pathology of influenza, 1920, Yale University Press, New Haven. Google Scholar15. Shope RE: The influenzas of swine and man, in Harvey Lectures, Vol. 31, 1935-36, Williams & Wilkins Company, Baltimore, p. 183. Google Scholar16. Francis T: Studies in influenza, Pennsylvania M. J. 40: 249, 1937. Google Scholar17. ShopeFrancis RET: The susceptibility of swine to the virus of human influenza, J. Exper. Med. 64: 791, 1936. CrossrefMedlineGoogle Scholar18. HaleMcKee WMAP (a) : The value of influenza vaccination when done at the beginning of an epidemic, Am. J. Hyg. 42: 21, 1945. (b) Hirst, G. K., Plummer, N., and Friedewald, W. F.: Human immunity following vaccination with formalinized influenza virus, Am. J. Hyg. 42: 45, 1945. Google Scholar19. HodgesMacLeod RGCM: Epidemic pneumococcal pneumonia. IV. The relationship of nonbacterial respiratory disease to pneumococcal pneumonia, Am. J. Hyg. 44: 231, 1946. MedlineGoogle Scholar20. Stuart-Harris CH: Influenza, 1953, Edw. Arnold, London. Google Scholar21. Francis T: Significance of antigenic variation of influenza viruses in relation to vaccination in man, Federation Proc. 11: 808, 1952. MedlineGoogle Scholar22. Francis T (a) : Handbuch der Virusforschung, Doerr and Hallauer, Editors, 2nd Ed., 1950, Springer, Vienna, p. 66. (b) Salk, J. E.: An interpretation of the significance of influenza virus variation for the development of an effective vaccine, Bull. New York Acad. Med. 28: 748, 1952. CrossrefGoogle Scholar23. Salk JE: Use of adjuvants in studies on influenza immunization. 3. Degree of persistence of antibody in human subjects two years after vaccination, J. A. M. A. 151: 1169, 1953. CrossrefMedlineGoogle Scholar24. FrancisShope TRE: Neutralization tests with sera of convalescent or immunized animals and the viruses of swine and human influenza, J. Exper. Med. 63: 645, 1936. CrossrefMedlineGoogle Scholar25. HennessyDavenport AVFM: Patterns of influenza antibody titers in gamma globulin and in pooled human sera (Abstract No. 1467), Federation Proc. 12: 446, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Presented as the James D. Bruce Memorial Lecture on Preventive Medicine at the Thirty-Fourth Annual Session of American College of Physicians, Atlantic City, New Jersey, April 13, 1953.From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor, Michigan.Certain of the studies referred to in this paper were conducted under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, and supported by the Office of the Surgeon General, Department of the Army, Washington, D. C. 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A two-cell theory of the original antigenic sinOriginal antigenic sin at the cellular level I. Antibodies produced by individual cells against cross-reacting haptensChronic oxidant exposure and epidemic influenzaStimulation in vitro with Protein Carrier of Antibodies against a HaptenAntibody-like Receptors on Immunocompetent CellsBibliographyTHE PRODUCTION OF ANTIBODYModeling the effects of prior infection on vaccine efficacyVirus of the 1918 Influenza Pandemic Era: New Evidence about Its Antigenic CharacterThe Role of the Carrier in Antibody FormationThe Influenza VirusesMyxovirenTHE CLINICAL EPIDEMIOLOGY OF ASIAN INFLUENZA*FRED M. DAVENPORT, M.D., ALBERT V. HENNESSY, M.D.Distribution and Significance of Asian and Other Influenza Antibodies in the Human PopulationOriginal Antigenic SinGenetics of Animal VirusesThe Nature of Serological Relationships Among Influenza VirusesTHE CURRENT STATUS OF THE CONTROL OF INFLUENZA*THOMAS FRANCIS JR., M.D.EPIDEMIOLOGY OF INFLUENZA COMPARATIVE SEROLOGICAL OBSERVATIONS IN ENGLAND AND THE UNITED STATESPandemic InfluenzaThe Status of Immunization in 1954 1 August 1953Volume 39, Issue 2Page: 203-221KeywordsArmed forcesBiologicsEpidemiologyPatientsPrevention, policy, and public healthPreventive medicineResearch laboratoriesSurgeons ePublished: 1 December 2008 Issue Published: 1 August 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...