gebhart/patrepeval huggingface dataset:
“Click-Functional” Block Copolymers Provide Precise Surface Functionality via Spin Coating (2008)

There are few existing methods for the quantitative functionalization of surfaces, especially for polymeric substrates. We demonstrate that alkyne end-functional diblock copolymers can be used to provide precise areal densities of reactive functionality on both hard (e.g., glass and silicon oxide) and soft (i.e., polymeric) substrates. Alkyne functionality is extremely versatile because the resultant functional surfaces are reactive toward azide functional molecules by Sharpless click chemistry. Spin-coated films of alpha-alkyne-omega-Br-poly( tert-butylacrylate- b-methylmethacrylate) (poly( tBA-MMA)) spontaneously self-assemble on the aforementioned substrates to present a surface monolayer of PtBA with a thickness in the range of 1 to 9 nm. The PMMA block physisorbs to provide multivalent anchoring onto hard substrates and is fixed onto polymer surfaces by interpenetration with the substrate polymer. The areal density of alkyne functional groups is precisely controlled by adjusting the thickness of the block copolymer monolayer, which is accomplished by changing either the spin coating conditions (i.e., rotational speed and solution concentration) or the copolymer molecular weight. The reactivity of surface-bound alkynes, in 1,3-dipolar cycloaddition reactions or by so-called "click chemistry", is demonstrated by covalent surface immobilization of fluorescently labeled azides. The modificed surfaces are characterized by atomic force microscopy (AFM), contact angle, ellipsometry, fluorescent imaging and angle-dependent X-ray photoelectron spectroscopy (ADXPS) measurements. Microarrays of covalently bound fluorescent molecules are created to demonstrate the approach and their performance is evaluated by determining their fluorescence signal-to-noise ratios.
Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin (Fragmin) in patients with venous thromboembolism and contraindications to coumarin. (1994)

Intravenous heparin followed by oral anticoagulant therapy (e. g. with coumarin) is still the most widely used treatment for deep venous thromboembolism. Self-administered subcutaneous injections of heparin have been thought of as a promising alternative to coumarin, but the high doses required for ongoing prophylaxis have raised concerns about the possible development of bone disease. Certainly, long-term heparin therapy has been reported to cause osteoporosis in both laboratory animals and humans. This study aimed to compare the efficacy and safety of unfractionated (UF) heparin with that of a low molecular weight heparin (Fragmin, Kabi Pharmacia) in the prevention of recurrent deep venous thrombosis (DVT) and pulmonary embolism (PE) in a consecutive series of patients with contraindications to coumarin therapy. The patients comprised 40 men and 40 women, aged between 19 and 92 years (mean age, 68 years). They had all previously been diagnosed as having acute DVT and had been treated with conventional doses of heparin while in hospital. All patients had at least one of the following conditions: recent blood loss (either spontaneous or during admission while receiving heparin therapy); active gastroduodenal ulcer disease; psychological or physical inability or unwillingness to understand and accept the need for regular laboratory monitoring during coumarin treatment; chronic alcoholism; dementia; pregnancy; recent neurosurgery, and pericardial effusion; or were over 80 years of age. They were randomly allocated to receive either UF heparin, 10,000 IU s.c. b.d., or Fragmin, 5000 IU anti-Factor Xa s.c. b.d., for a period of 3-6 months.(ABSTRACT TRUNCATED AT 250 WORDS)
Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape (2012)

Small molecule inhibitors of BCR signaling kinases, Bruton's tyrosine kinase (Btk) inhibitor ibrutinib and the phosphoinositide 3'-kinase delta (PI3Kδ) inhibitor GS-1101, are currently transforming the landscape of CLL therapy. This development exemplifies that the microenvironment has become a lively successful area of translational research.
The Genetic Landscape of the Childhood Cancer Medulloblastoma (2010)

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high-density microarrays and sequenced all known protein-coding genes and microRNA genes using Sanger sequencing in a set of 22 MBs. We found that, on average, each tumor had 11 gene alterations, fewer by a factor of 5 to 10 than in the adult solid tumors that have been sequenced to date. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone-lysine N-methyltransferase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.
Both Group IB and Group IIA Secreted Phospholipases A2 Are Natural Ligands of the Mouse 180-kDa M-type Receptor (1999)

Snake venom and mammalian secreted phospholipases A 2 (sPLA 2 s) have been associated with toxic (neurotoxicity, myotoxicity, etc.), pathological (inflammation, cancer, etc.), and physiological (proliferation, contraction, secretion, etc.) processes. Specific membrane receptors (M and N types) for sPLA 2 s have been initially identified with snake venom sPLA 2 s as ligands, and the M-type 180-kDa receptor was cloned from different animal species. This paper addresses the problem of the endogenous ligands of the M-type receptor. Recombinant group IB and group IIA sPLA 2 s from human and mouse species have been prepared and analyzed for their binding properties to M-type receptors from different animal species. Both mouse group IB and group IIA sPLA 2 s are high affinity ligands (in the 1-10 nM range) for the mouse M-type receptor. These two sPLA 2 s are expressed in the mouse tissues where the M-type receptor is also expressed, making it likely that both types of sPLA 2 s are physiological ligands of the mouse M-type receptor. This conclusion does not hold for human group IB and IIA sPLA 2 s and the cloned human M-type receptor. The two mouse sPLA 2 s have relatively high affinities for the mouse M-type receptor, but they can have much lower affinities for receptors from other animal species, indicating that species specificity exists for sPLA 2 binding to M-type receptors. Caution should thus be exerted in avoiding mixing sPLA 2 s, cells, or tissues from different animal species in studies of the biological roles of mammalian sPLA 2 s associated with an action through their membrane receptors.
The Prognostic Value of F-18 Fluorodeoxyglucose Bone Marrow Uptake in Patients With Recent Diagnosis of Multiple Myeloma (2009)

Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM.
A Novel Low-Cost, High-Efficiency Micromachined Silicon Solar Cell (2004)

This letter presents a new process for the fabrication of solar cells and modules from single crystal silicon wafers with substantially reduced silicon consumption and processing effort compared to conventional wafer-based cells. The technique of narrow trench etching in an alkaline solution is used to create a series of thin silicon strips extending vertically through the wafer. By turning the silicon strips on their side, a large increase in surface area is achieved. Individual cells fabricated using the new process have reached efficiencies up to 18.5% while a 575 cm/sup 2/ module incorporating a rear reflector and a cell surface coverage of 50% has displayed an efficiency of 12.3% under standard rating conditions. The technique has the potential to reduce silicon consumption by a factor of 10 compared to standard wafer-based silicon solar cells and, therefore, to dramatically reduce the dependence to the expensive silicon feedstock.
Single global lock semantics in a weakly atomic STM (2008)

As memory transactions have been proposed as a language-level replacement for locks, there is growing need for well-defined semantics. In contrast to database transactions, transaction memory (TM) semantics are complicated by the fact that programs may access the same memory locations both inside and outside transactions. Strongly atomic semantics, where non-transactional accesses are treated as implicit single-operation transactions, remain difficult to provide without specialized hardware support and/or significant performance overhead. As an alternative, many in the community have informally proposed that a single global lock semantics [16, 9], where transaction semantics are mapped to those of regions protected by a single global lock, provide an intuitive and efficiently implementable model for programmers. In this paper, we explore the implementation and performance implications of single global lock semantics in a weakly atomic STM from the perspective of Java, and we discuss why even recent STM implementations fall short of these semantics. We describe a new weakly atomic Java STM implementation that provides single global lock semantics while permitting concurrent execution, but we show that this comes at a significant performance cost. We also propose and implement various alternative semantics that loosen single lock requirements while still providing strong guarantees. We compare our new implementations to previous ones, including a strongly atomic STM. [22]
Sidewall functionalization of single-walled carbon nanotubes with organic peroxidesElectronic supplementary information (ESI) available: Fig. S1: Raman spectra of pristine and functionalized SWNTs. Fig. S2: UV-Vis-NIR spectra of pristine and functionalized SWNTs. See http://www.rsc.org/suppdata/cc/b2/b209456h/ (2003)

Single-wall carbon nanotubes (SWNTs) and their fluorinated derivatives (F-SWNTs) were reacted with organic peroxides including benzoyl and lauroyl peroxide to produce phenyl and undecyl sidewall functionalized SWNTs, respectively, which were characterized by Raman, FTIR, and UV-Vis-NIR spectra as well as TGA/MS, TGA/FTIR, and TEM data.
Synthesis and characterization of a catalytically active nickel silicoaluminophosphate catalyst for the conversion of methanol to ethene (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of a catalytically active nickel silicoaluminophosphate catalyst for the conversion of methanol to etheneJ. M. Thomas, Y. Xu, C. R. A. Catlow, and J. W. CouvesCite this: Chem. Mater. 1991, 3, 4, 667–672Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/cm00016a020https://doi.org/10.1021/cm00016a020research-articleACS PublicationsRequest reuse permissionsArticle Views383Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Enhanced piezoelectric properties of barium titanate single crystals with different engineered-domain sizes (2005)

For tetragonal barium titanate (BaTiO3) single crystals, an electric field (E-field) applied along the [111]c direction can induce an engineered-domain configuration in these crystals. In this study, such engineered-domain configurations of different domain sizes were induced in BaTiO3 single crystals, and their piezoelectric properties were investigated as a function of domain size. Prior to this study, the dependences of the domain configuration on the temperature and E-field were investigated using a polarizing microscope in order to understand the optimum poling condition for fine- and coarse-domain configurations. We found that above the Curie temperature (TC) of 132.2 °C, when an E-field above 6.0kV∕cm was applied along the [111]c direction, an engineered domain with a fine-domain configuration appeared. Moreover, it was also found that this fine-domain configuration remained stable at room temperature without the E-field. On the other hand, the coarse-domain configuration was obtained upon poling at just below TC. Finally, the piezoelectric properties of 31 resonators with different domain sizes of 40–5.5μm were measured. As a result, it was found that the piezoelectric properties, such as d31 and k31, increased significantly with decreasing domain size.
The use of heart rate monitoring in the estimation of energy expenditure: a validation study using indirect whole-body calorimetry (1989)

1. A modified heart rate (HR) method for predicting total energy expenditure (TEE) was cross-validated against whole-body calorimetry (CAL). Minute-by-minute HR was converted to energy expenditure (EE) using individual calibration curves when HR exceeded a pre-determined 'FLEX' value designed to discriminate periods of activity. ('FLEX' HR was defined as the mean of the highest HR during rest and the lowest HR during the lightest imposed exercise.) Sedentary EE (below FLEX) was calculated as the mean EE during lying down, sitting and standing at rest. Sleeping EE was calculated as basal metabolic rate (BMR) predicted from standard equations. 2. Calibration curves of oxygen consumption v. HR for different postures at rest and during exercise were obtained for twenty healthy subjects (eleven male, nine female); mean r 0.941 (SD 0.04). The mean FLEX HR for men and women were 86 (SD 10) and 96 (SD 6) beats/min respectively. 3. Simultaneous measurements of HR and EE were made during 21 h continuous CAL, which included 4 x 30 min imposed exercise (cycling, rowing, stepping, jogging). HR exceeded FLEX for a mean of 98 (SD 41) min. Mean TEE by CAL (TEE.CAL) was 8063 (SD 1445) kJ. 4. The HR method yielded a mean non-significant underestimate in TEE (TEE.HR) of 1.2 (SD 6.2)% (range -11.4 to +10.6%). Regression of TEE.HR (Y) v. TEE.CAL (X) yielded Y = 0.868 X + 927 kJ, r 0.943, SE of the estimate 458 kJ, n 20. 5. The satisfactory predictive power and low cost of the method makes it suitable for many field and epidemiological applications.
Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1 (2000)

Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-deficient mice in similar amounts as in serum from wild-type mice. These findings were confirmed in vitro by flow cytometric analysis of lipopolysaccharide-stimulated spleen cells, and cICAM-enzyme-linked immunosorbent assay analysis of supernatants of cultured spleen cells. To analyze for the source of cICAM-1, spleen cell RNA was isolated and ICAM-1 RNA was amplified by reverse transcriptase-polymerase chain reaction using primers binding in the 5' and 3' untranslated regions. Different fragments were cloned and sequenced. In wild-type RNA the common 5 domain form of ICAM-1 was identified. In RNA from ICAM-1 mutant mice only 3 smaller fragments were found. Sequencing these fragments identified 3 alternatively spliced isoforms of ICAM-1, lacking 2 or 3 extracellular domains. However, in all spliced fragments the transmembrane domain was included. Therefore, we postulate that circulating forms of ICAM-1 are generated by proteolytic cleavage of membranous ICAM-1. The data indicate that the expression of membranous ICAM-1 and the appearance of circulating forms in serum are independently regulated mechanisms. (Blood. 2000;95:1350-1355)
The drug resistance results of 29 strains Mycobacterium fortuitum (2004)

Objective To determine the drug resistance on Mycobacterium fortuitum .Methods 29 strains M.fortuitum of clinical isolates had been identified by conventional and molecular biological identification methods were uesed for susceptibility tests to the main anti-tuberculosis drugs.Results The isolates were susceptible to OFLX and LVFX,resisted to all single anti-tuberculosis drug;The results of malti-drugs susceptibility test showed that the isolates resistant to two or three anti-tuberculosis drugs at the low concentration but susceptible at the high concentrat .Conclusion It will be possible toget higher cure rate,if the clinical cases should been treated with susceptible antibiotics in combination with anti-tuberculosis drugs in synergism.
Making a Science of Model Search: Hyperparameter Optimization in Hundreds of Dimensions for Vision Architectures (2013)

Many computer vision algorithms depend on configuration settings that are typically hand-tuned in the course of evaluating the algorithm for a particular data set. While such parameter tuning is often presented as being incidental to the algorithm, correctly setting these parameter choices is frequently critical to realizing a method’s full potential. Compounding matters, these parameters often must be re-tuned when the algorithm is applied to a new problem domain, and the tuning process itself often depends on personal experience and intuition in ways that are hard to quantify or describe. Since the performance of a given technique depends on both the fundamental quality of the algorithm and the details of its tuning, it is sometimes difficult to know whether a given technique is genuinely better, or simply better tuned. In this work, we propose a meta-modeling approach to support automated hyperparameter optimization, with the goal of providing practical tools that replace hand-tuning with a reproducible and unbiased optimization process. Our approach is to expose the underlying expression graph of how a performance metric (e.g. classification accuracy on validation examples) is computed from hyperparameters that govern not only how individual processing steps are applied, but even which processing steps are included. A hyperparameter optimization algorithm transforms this graph into a program for optimizing that performance metric. Our approach yields state of the art results on three disparate computer vision problems: a face-matching verification task (LFW), a face identification task (PubFig83) and an object recognition task (CIFAR-10), using a single broad class of feed-forward vision architectures.
Cloning and sequencing of agaA, a unique agarase 0107 gene from a marine bacterium, Vibrio sp. strain JT0107 (1993)

An agarase gene (agaA) was cloned from genomic DNA of Vibrio sp. strain JT0107. An open reading frame of 2,985 nucleotides gave a primary translation product composed of the mature protein, agarase 0107 (975 amino acid residues, with a molecular weight of 105,271) and a signal peptide of 20 amino acid residues at the N terminus. Comparison of the deduced amino acid sequence of agarase 0107 with those of Streptomyces coelicolor and Pseudomonas atlantica suggests that these enzymes share two regions in common. The AgaA protein which was expressed in Escherichia coli had the agarase activity. Agarase 0107 hydrolyzes not only agarose but also neoagarotetraose [O-3,6-anhydro-alpha-L-galactopyranosyl (1-->3)-O-beta-D-galactopyranosyl(1-->4)-O-3,6-anhydro-alpha-L-galact opy ranosyl (1-->3)-D-galactose] to yield neoagarobiose [O-3,6-anhydro-alpha-L-galactopyranosyl(1-->3)-D-galactose]. This is a quite unique characteristic for a beta-agarase.
A reliable and efficient multicast for broadband broadcast networks (1987)

A reliable and efficient data transfer protocol is proposed for multicast applications in broadband broadcast networks. The protocol is based on negative acknowledgements, with several enhancements so that it matches most of the functionality of a positive acknowledgement based protocol. The protocol makes the best use of resources in the broadband network environment by conserving processing and trading off transmission and storage resources. The performance of this protocol is compared with the positive acknowledgement based protocol on the basis of maximum throughput as a function of group size for lecture and conference applications.
Three-Dimensional Analysis and Classification of Arteries in the Skin and Subcutaneous Adipofascial Tissue by Computer Graphics Imaging (1998)

To develop new types of surgical flaps that utilize portions of the skin and subcutaneous tissue (e.g., a thin flap or an adipofascial flap), three-dimensional investigation of the vasculature in the skin and subcutaneous tissue has been anticipated. In the present study, total-body arterial injection and three-dimensional imaging of the arteries by computer graphics were performed. The full-thickness skin and subcutaneous adipofascial tissue samples, which were obtained from fresh human cadavers injected with radio-opaque medium, were divided into three distinct layers. Angiograms of each layer were introduced into a personal computer to construct three-dimensional images. On a computer monitor, each artery was shown color-coded according to the three portions: the deep adipofascial layer, superficial adipofascial layer, and dermis. Three-dimensional computerized images of each artery in the skin and subcutaneous tissue revealed the components of each vascular plexus and permitted their classification into six types. The distribution of types in the body correlated with the tissue mobility of each area. Clinically, appreciation of the three-dimensional structure of the arteries allowed the development of several new kinds of flaps.
Optimisation for improved short-channel performanceofsurrounding/cylindrical gate MOSFETs (2001)

A new technique is proposed to optimise the device parameters of a thin-film fully depleted SGT MOSFET to minimise short-channel effects. The model offers new opportunities for realising future ULSI circuits with SGTs.
Soil Degradation and Soil Productivity Restoration and Maintenance in Hilly Land of Southern China (2002)

Soil fertility degeneration and land productivity loss caused by soil erosion are severe problems in hilly land of southern China. A long term field experiment was conducted during 1984 to 1993 to determine soil productivity in a typical degraded hilly area of purple soil (orthic Entisol) in Yanting, Sichuan, China. Results showed that a conservation tillage system with ridge-furrow cropping and seasonal no-tillage increased topsoil depth by 118 mm over the conventional tillage. Soil structure and soil physical, chemical and biological characteristics were also improved when conservation tillage was adopted. In conclusion, this system is suitable conserving soil and water resources and therefore for restoring dry land crop production in degraded hilly land of southern China