gebhart/patrepeval huggingface dataset:
Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor‐Selective Agonists: Novel Halogenated Analogues of 4‐[1‐(3,5,5,8,8‐Pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic Acid (Bexarotene) (2012)

The synthesis of halogenated analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), known commonly as bexarotene, and their evaluation for retinoid X receptor (RXR)-specific agonist performance is described. Compound 1 is FDA approved to treat cutaneous T-cell lymphoma (CTCL); however, bexarotene treatment can induce hypothyroidism and elevated triglyceride levels, presumably by disrupting RXR heterodimer pathways for other nuclear receptors. The novel halogenated analogues in this study were modeled and assessed for their ability to bind to RXR and stimulate RXR homodimerization in an RXRE-mediated transcriptional assay as well as an RXR mammalian-2-hybrid assay. In an array of eight novel compounds, four analogues were discovered to promote RXR-mediated transcription with EC(50) values similar to that of 1 and are selective RXR agonists. Our approach also uncovered a periodic trend of increased binding and homodimerization of RXR when substituting a halogen atom for a proton ortho to the carboxylic acid on 1.
Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector (1981)

We have constructed a simian virus 40 recombinant carrying a fragment of DNA from hepatitis B virus. Cultured monkey kidney cells infected with this recombinant produce hepatitis B surface antigen. The antigen is excreted into the culture medium as 22-nm particles with the same physical properties, antigenic composition, and constituent polypeptides as those found in the sera of patients with type B hepatitis.
Study of1+States inV48 (1973)

15 states in $^{48}\mathrm{V}$ have been studied by means of the $^{46}\mathrm{Ti}(^{3}\mathrm{He},p)^{48}\mathrm{V}$ reaction induced by a 17-MeV $^{3}\mathrm{He}^{++}$ beam from the Argonne tandem Van de Graaff. The proton angular distributions led to the identification of one ${0}^{+}$ state (the isobaric analog of the $^{48}\mathrm{Ti}$ ground state) and 7 ${1}^{+}$ states. The excitation energies of the ${1}^{+}$ states are compared with those predicted by a shell-model calculation which assumed a ${(\ensuremath{\pi}{f}_{\frac{7}{2}})}^{3}{(\ensuremath{\nu}{f}_{\frac{7}{2}})}^{\ensuremath{-}3}$ configuration. The differential cross sections for populating states in $^{48}\mathrm{V}$ by transferring an $n\ensuremath{-}p$ pair with 0 or 0 + 2 units of angular momenta are compared with similar cross sections in neighboring nuclei to investigate possible regularities in this mass region. The $\ensuremath{\gamma}$ decay of the ${0}^{+}$ and ${1}^{+}$ states was determined by studying $p\ensuremath{-}\ensuremath{\gamma}$ coincidences associated with the $^{48}\mathrm{Ti}(^{3}\mathrm{He},p\ensuremath{\gamma})^{48}\mathrm{V}$ reaction. The $\ensuremath{\gamma}$ decay of the ${1}^{+}$ states shows a definite pattern which is compared with one based on a selection rule involving the signatures of the wave functions describing the ${1}^{+}$ states.
Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. (2000)

In this study, Harpagophytum was at least as effective as a reference drug (diacerhein) in the treatment of knee or hip osteoarthritis and reduced the need for analgesic and nonsteroidal anti-inflammatory therapy.
Characterization of the transposition pattern of the Ac element in Arabidopsis thaliana using endonuclease I- Sce I (1997)

We have investigated physical distances and directions of transposition of the maize transposable element Ac in Arabidopsis thaliana . We prepared a transferred DNA (T-DNA) construct that carried a non-autonomous derivative of Ac with a site for cleavage by endonuclease I- Sce I (designated dAc-I-RS element). Another cleavage site was also introduced into the T-DNA region outside dAc-I-RS. Three transgenic Arabidopsis plants were generated, each of which had a single copy of the T-DNA at a different chromosomal location. These transgenic plants were crossed with the Arabidopsis that carried the gene for Ac transposase and progeny in which dAc-I-RS had been transposed were isolated. After digestion of the genomic DNA of these progeny with endonuclease I- Sce I, sizes of segment of DNA were determined by pulse-field gel electrophoresis. We also performed linkage analysis for the transposed elements and sites of mutations near the elements. Our results showed that 50% of all transposition events had occurred within 1,700 kb on the same chromosome, with 35% within 200 kb, and that the elements transposed in both directions on the chromosome with roughly equal probability. The data thus indicate that the Ac – Ds system is most useful for tagging of genes that are present within 200 kb of the chromosomal site of Ac in Arabidopsis . In addition, determination of the precise localization of the transposed dAc-I-RS element should definitely assist in map-based cloning of genes around insertion sites.
Isolation and characterization of a cDNA clone encoding wheat germ agglutinin (1987)

Two sets of synthetic oligonucleotides coding for amino acids in the amino- and carboxyl-terminal portions of wheat germ agglutinin were synthesized and used as hybridization probes to screen cDNA libraries derived from developing embryos of tetraploid wheat. The nucleotide sequence for a cDNA clone recovered from the cDNA library was determined by dideoxynucleotide chain-termination sequencing in vector M13. The amino acid sequence deduced from the DNA sequence indicated that this cDNA clone (pNVR1) encodes isolectin 3 of wheat germ agglutinin. Comparison of the deduced amino acid sequence of clone pNVR1 with published sequences indicates isolectin 3 differs from isolectins 1 and 2 by 10 and 8 amino acid changes, respectively. In addition, the protein encoded by pNVR1 extends 15 amino acids beyond the carboxyl terminus of the published amino acid sequence for isolectins 1 and 2 and includes a potential site for N-linked glycosylation. Utilizing the insert of pNVR1 as a hybridization probe, we have demonstrated that the expression of genes for wheat germ agglutinin is modulated by exogenous abscisic acid. Striking homology is observed between wheat germ agglutinin and chitinase, both of which are proteins that bind chitin.
A New Route to Heterosilsesquioxane Frameworks (1998)

The substitution of an O atom in the Cy<sub>8</sub> Si<sub>8</sub> O<sub>12</sub> framework by a heteroatom or a heteroatom-containing group (Z) provides a simple route to discrete heterosilsesquioxane frameworks 1. In this reaction the Cy<sub>8</sub> Si<sub>8</sub> O<sub>12</sub> framework is initially opened with triflic acid and then treated with different nucleophiles (Cy=cyclohexyl; Z=NPh, SO<sub>4</sub> , nBuBO<sub>2</sub> , CrO<sub>4</sub> ).
Cross-reactivity of amylin with calcitonin-gene-related peptide binding sites in rat liver and skeletal muscle membranes (1991)

This study examines whether the high degree of sequence identity between amylin and calcitonin-gene-related peptide (CGRP) is reflected in their cross-reactivity at the level of membrane receptor binding. Rat liver plasma membranes contain a specific saturable binding site for 125I-labelled human CGRP-1. Binding reached equilibrium within 30 min and was rapidly reversed by re-incubating membranes in the presence of 1 microM human CGRP. In addition, the presence of 50 mM- or 500 mM-NaCl lowered specific binding by 30% and 77% respectively. Scatchard analysis was consistent with a single high-affinity site with a dissociation constant (Kd) of 0.125 nM and binding capacity (Bmax.) of 580 fmol/mg of membrane protein. Specific binding of 125I-labelled human CGRP-1 to both liver and skeletal muscle membranes was inhibited by human CGRP-1 [IC50 (concn. causing half-maximal inhibition of binding) 0.1-0.3 nM], and rat amylin (IC50 10 nM), but not by human calcitonin. Covalent cross-linking of 125I-CGRP to its binding site in rat skeletal muscle and liver membranes resulted in labelling of a major species of about 70 kDa under reducing conditions and about 55 kDa under alkylating conditions, as visualized on SDS/PAGE. These radiolabelled species were absent in the presence of CGRP or amylin at 1 microM. These results are indicative of a common binding site for both CGRP and amylin in liver and skeletal muscle, and it is suggested that both peptides mediate their actions through the same effector system. The normal physiological importance and the relevance to the pathology of type 2 diabetes of these data are discussed.
Electrocatalytic Reduction of CO2 to CO With Re-Pyridyl-NHCs: Proton Source Influence on Rates and Product Selectivities (2016)

A series of four electron-deficient-substituted Re(I) pyridyl N-heterocyclic carbene (pyNHC) complexes have been synthesized, and their electrocatalytic reduction of CO2 has been evaluated by cyclic voltammetry and controlled potential electrolysis experiments. All of the catalysts were evaluated by cyclic voltammetry under inert atmosphere and under CO2 and compared to the known benchmark catalyst Re(bpy)(CO)3Br. Among the four Re-NHC catalysts, Re(pyNHC-PhCF3)(CO)3Br (2) demonstrated the highest catalytic rate (icat/ip)(2) at the first and second reduction events with a value of 4 at the second reduction potential (TOF = 0.8 s(-1)). The rate of catalysis was enhanced through the addition of proton sources (PhOH, TFE, and H2O; TOF up to 100 s(-1); (icat/ip)(2) = 700). Controlled potential electrolysis shows Faradaic efficiencies (FE) for CO production and accumulated charge for the Re(pyNHC-PhCF3)(CO)3Br catalyst exceed those of the benchmark catalyst in the presence of 2 M H2O (92%, 13 C at 1 h versus 61%, 3 C for the benchmark catalyst) under analogous experimental conditions. A peak FE of 100% was observed during electrolysis with Re(pyNHC-PhCF3)(CO)3Br.
Fast rotation invariant multi-view face detection based on real adaboost (2004)

In this paper, we propose a rotation invariant multi-view face detection method based on Real Adaboost algorithm. Human faces are divided into several categories according to the variant appearance from different viewpoints. For each view category, weak classifiers are configured as confidence-rated look-up-table (LUT) of Haar feature. Real Adaboost algorithm is used to boost these weak classifiers and construct a nesting-structured face detector. To make it rotation invariant, we divide the whole 360-degree range into 12 sub-ranges and construct their corresponding view based detectors separately. To improve performance, a pose estimation method is introduced and results in a processing speed of four frames per second on 320/spl times/240 sized image. Experiments on faces with 360-degree in-plane rotation and /spl mnplus/90-degree out-of-plane rotation are reported, of which the frontal face detector subsystem retrieves 94.5% of the faces with 57 false alarms on the CMU+MlT frontal face test set and the multi-view face detector subsystem retrieves 89.8% of the faces with 221 false alarms on the CMU profile face test set.
The temperature and coverage dependences of adsorbed formic acid and its conversion to formate on platinum(111) (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe temperature and coverage dependences of adsorbed formic acid and its conversion to formate on platinum(111)M. R. Columbia, A. M. Crabtree, and P. A. ThielCite this: J. Am. Chem. Soc. 1992, 114, 4, 1231–1237Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/ja00030a017https://doi.org/10.1021/ja00030a017research-articleACS PublicationsRequest reuse permissionsArticle Views595Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. (1996)

Using a mRNA differential screening of fibroblasts differing for the expression of c-fos we isolated a c-fos-induced growth factor (FIGF). The deduced protein sequence predicts that the cDNA codes for a new member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. Northern blot analysis shows that FIGF expression is strongly reduced in c-fos-deficient cells. Transfection of exogenous c-fos driven by a constitutive promoter restores the FIGF expression in these cells. In contrast, both PDGF and VEGF expression is unaffected by c-fos. FIGF is a secreted dimeric protein able to stimulate mitogenic activity in fibroblasts. FIGF overexpression induces morphological alterations in fibroblasts. The cells acquire a spindle-shaped morphology, become more refractive, disorganized, and detach from the plate. These results imply that FIGF is a downstream growth and morphogenic effector of c-fos. These results also suggest that the expression of FIGF in response to c-fos activation induces specific differentiation patterns and its aberrant activation contributes to the malignant phenotype of tumors.
Intratumoral Delivery of Low Doses of Anti-CD40 mAb Combined With Monophosphoryl Lipid A Induces Local and Systemic Antitumor Effects in Immunocompetent and T Cell-Deficient Mice (2012)

In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was capable of priming macrophages to subsequent ex vivo activation by MPL in immunocompetent and T-cell-depleted mice. Intraperitoneal injections of anti-CD40+MPL induced additive to synergistic suppression of poorly immunogenic B16-F10 melanoma growing subcutaneously in syngeneic mice. When anti-CD40+MPL were injected directly into the subcutaneous tumor, the combination treatment was more effective, even with a 25-fold reduction in dose. Low-dose intratumoral treatment also slowed the growth of a secondary tumor growing simultaneously at a distant, untreated site. Antitumor effects were also induced in severe combined immunodeficiency mice and in T-cell-depleted C57BL/6 mice. Taken together, our results show that the antitumor effects of anti-CD40 are enhanced by subsequent treatment with MPL, even in T-cell-deficient hosts. These preclinical data suggest that an anti-CD40+MPL combined regimen is appropriate for clinical testing in human patients, including cancer patients who may be immunosuppressed from prior chemotherapy.
Tailorable groupware (1998)

article Free Access Share on Tailorable groupware: issues, methods, and architectures Authors: Anders March View Profile , Oliver Stiemerling View Profile , Volker Wulf View Profile Authors Info & Claims ACM SIGCHI BulletinVolume 30Issue 2April 1998 pp 40–42https://doi.org/10.1145/279044.279146Online:01 April 1998Publication History 6citation51DownloadsMetricsTotal Citations6Total Downloads51Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment (2015)

Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.
Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration (1998)

The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits. Rabbits were divided evenly among four treatments: autograft, absorbable C (Helistat), 35 microg of rhBMP-2 combined with absorbable C (rhBMP-2/C), and untreated CSDs. The two euthanasia periods were 4 and 8 weeks. Radiographs were taken the day of surgery, every 2 weeks, and at term and the percent of radiopacity was measured. Data analysis revealed a time-dependent increase in the percent radiopacity with rhBMP-2/C. Histological examination revealed the rhBMP-2/C treatment regenerated osseous contour by 8 weeks. According to quantitative histomorphometry, the CSD and C groups had significantly less new bone than either autograft or rhBMP-2/C (p < or = 0.05). The results suggest that rhBMP-2/C could be an effective therapy to restore segmental bone defects.
On dangers of overtraining steganography to incomplete cover model (2011)

A modern direction in steganography calls for embedding while minimizing a distortion function defined in a sufficiently complex model space. In this paper we show that, quite surprisingly, even a high-dimensional cover model does not automatically guarantee immunity to simple attacks. Moreover, the security can be compromised if the distortion is optimized to an incomplete cover model. We demonstrate these pitfalls with two recently proposed steganographic schemes and support our arguments experimentally. Finally, we discuss how the corresponding models might be modified to eliminate the security flaws.
Effects of colostral antibody on susceptibility of calves to Cryptosporidium parvum infection. (1989)

Effects of colostral antibody on susceptibility of calves to Cryptosporidium parvum infection were examined. Six calves were fed pooled colostrum that contained C parvum antibody, 6 times daily (at 4-hour intervals) for 7 days and then milk replacer for 7 days. Colostrum was obtained from healthy cows or cows inoculated parenterally with C parvum oocysts before parturition. Antibody content was determined in serum and colostrum whey, using an ELISA for anticryptosporidia immunoglobulin. Six calves were fed colostrum from healthy cows 1 time, and then milk replacer 6 times daily for 14 days. On day 1, all calves were challenge exposed with C parvum, PO, and were monitored daily for diarrhea and oocyst shedding. Bovine colostrum containing specific antibody to C parvum, at ELISA titers up to 10,240, was not effective in protecting calves against challenge exposure to C parvum.
Photoacoustic IR Spectroscopy: Instrumentation, Applications and Data Analysis (2010)

This invaluable and up-to-date source on instruments and applications covers everything needed to employ a technique for investigating various gases and materials, including biomaterials. It includes the latest developments in light sources, signal recovery and numerical methods. There is no other single publication that reviews the entire subject of photoacoustic infrared spectroscopy in such detail. Physicists, chemists, and spectroscopists in both academic and industrial laboratories, polymer and organic chemists, analysts in industry, forensic and government laboratories, and materials scientists will find this book to be a vital resource.
Rock 'n' Scroll is here to stay [user interface] (2000)

The article outlines the development of the Rock 'n' Scroll input method which lets users gesture to scroll, select, and command an application without resorting to buttons, touchscreens, spoken commands, or other input methods. The Rock'n' Scroll user interface shows how inertial sensors in handheld devices can provide additional function beyond "tilt-to-scroll". By also using them to recognize gestures, a significantly richer vocabulary for controlling the device is available that implements an electronic photo album, pager, or other limited function digital appliance without any additional input methods. The examples presented offer a glimpse at the freedom for both device designers and users inherent in devices that can be held in either hand, at any orientation, operated with mittens on, or not in the hand at all.
Color correction for an image sequence (1995)

The color correction technique presented constructs a mapping from the registered overlapping regions of two adjacent images in an image sequence. The method involves two main steps. In the first step we use multiple regression to find the relationship between the registered overlapping regions of two adjacent images in the sequence. We then use the derived mapping to correct the color in one image so that it matches the adjacent image. After describing the basic method and discussing strategies far dealing with specific problems that arise, we present and analyze relevant test results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Identifying Regulatory B Cells (B10 Cells) that Produce IL-10 in Mice (2010)

Regulatory B cells that produce IL-10 are now recognized as an important component of the immune system. We have identified a rare antigen-specific regulatory B-cell subset with a unique CD1d(hi)CD5(+)CD19(hi) phenotype in the spleens of wild-type mice. We call these cells B10 cells because they are responsible for most B cell IL-10 production, they appear to only produce IL-10 after 5 h of in vitro stimulation, and to distinguish them from other potential regulatory B cell subsets. B10 progenitor (B10pro) cells have also been identified within the spleen CD1d(hi)CD5(+)CD19(hi) B-cell subset, and within other lymphoid tissues. Herein, four methods for identifying and isolating regulatory IL-10-producing B10 cells in mice are provided. The first two methods are used to identify and enumerate B10 and B10pro cells based on their cell surface phenotypes and cytoplasmic IL-10 staining. The last two methods are used to isolate viable B10 cells for adoptive transfer and functional studies. These methods should facilitate the study of B10 cells in inflammation, autoimmune disease, immune responses, and cancer therapy.