gebhart/patrepeval huggingface dataset:
Improved Security for a Ring-Based Fully Homomorphic Encryption Scheme. (2013)

In 1996, Hoffstein, Pipher and Silverman introduced an efficient lattice based encryption scheme dubbed NTRUEncrypt. Unfortunately, this scheme lacks a proof of security. However, in 2011, Stehle and Steinfeld showed how to modify NTRUEncrypt to reduce security to standard problems in ideal lattices. In 2012, Lopez-Alt, Tromer and Vaikuntanathan proposed a fully homomorphic scheme based on this modified system. However, to allow homomorphic operations and prove security, a non-standard assumption is required. In this paper, we show how to remove this non-standard assumption via techniques introduced by Brakerski and construct a new fully homomorphic encryption scheme from the Stehle and Steinfeld version based on standard lattice assumptions and a circular security assumption. The scheme is scale-invariant and therefore avoids modulus switching and the size of ciphertexts is one ring element. Moreover, we present a practical variant of our scheme, which is secure under stronger assumptions, along with parameter recommendations and promising implementation results. Finally, we present an approach for encrypting larger input sizes by extending ciphertexts to several ring elements via the CRT on the message space.
Effect of serum-clot contact time on clinical chemistry laboratory results (1998)

The effect of serum-clot contact time on laboratory results was studied by dividing each blood specimen into four blood collection tubes. The control sera were separated from the clot within 30 min of the collection. The other tubes were incubated at 32 degrees C, and the sera were separated at 3, 6, and 24 h. The sera were stored at 4 degrees C and analyzed at the same time. The stability of the tests was determined by comparing the results of the 3-, 6-, and 24-h samples with the values from the 30-min samples. The acceptable limits around the 30-min values were derived from the analytical and intraindividual biological variation of the tests. A total of 63 analytes were studied. Potassium, phosphorous, and glucose were the least stable, and the serum should be separated from the clot within 3 h for these analytes. Albumin, bicarbonate, chloride, C-peptide, HDL-cholesterol, iron, LDL-cholesterol, and total protein should be separated within 6 h. The other analytes were stable for 24 h of serum-clot contact.
Biomass pyrolysis for chemicals (2011)

The problems that are associated with the use of fossil fuels demand a transition to renewable sources for energy and materials. Biomass is a natural treasure for chemicals that, to date, have been made from fossil resources. Unfortunately, the heterogeneiety and complexity of biomass still precludes exploitation of its full potential. New technologies for economical valorization of biomass are under development, but cannot yet compete with petrochemical processes. However, rising prices of fossil resources will inevitably lead to replacement of oil refineries with biorefineries. A biorefinery uses various types of biomass feedstocks that are processed via different technologies into heat, power and various products. The biorefinery is self sustainable with respect to heat and power and puts no burden on the environment. Thermochemical processes such as fast pyrolysis can play an important role in biorefineries and this article presents a review of some pyrolysis-based technologies.
Preferential Adhesion of Prostate Cancer Cells to a Human Bone Marrow Endothelial Cell Line (1998)

These data suggest that the propensity of prostate cancer cells to establish themselves in bone is due, at least in part, to their preferential adhesion to human bone marrow endothelial cells.
Synthesis of Gallium Nitride Nanorods Through a Carbon Nanotube-Confined Reaction (1997)

Gallium nitride nanorods were prepared through a carbon nanotube–confined reaction. Ga 2 O vapor was reacted with NH 3 gas in the presence of carbon nanotubes to form wurtzite gallium nitride nanorods. The nanorods have a diameter of 4 to 50 nanometers and a length of up to 25 micrometers. It is proposed that the carbon nanotube acts as a template to confine the reaction, which results in the gallium nitride nanorods having a diameter similar to that of the original nanotubes. The results suggest that it might be possible to synthesize other nitride nanorods through similar carbon nanotube–confined reactions.
Green‐fluorescent protein fusions for efficient characterization of nuclear targeting (1997)

The green-fluorescent protein (GFP) from Aequorea victoria has been shown to be a convenient and flexible reporter molecule within a variety of eukaryotic systems, including higher plants. It is particularly suited for applications in vivo, since the mechanism of fluorophore formation involves an intramolecular autoxidation and does not require exogenous co-factors. Unlike standard histochemical procedures of fixation and staining required for analysis of the cellular or tissue-specific expression of other popular reporter molecules, such as the beta-glucuronidase (GUS) marker, analysis of GFP can be done in living cells with no specific pretreatments. This implies that GFP might also be particularly suited for studies of intracellular protein targeting. In this paper, the use of GUS is compared with that of GFP for the analysis of nuclear targeting in tobacco. A novel oligopeptide motif from a tobacco protein is described which confers nuclear localization of GUS. The use of this oligopeptide and two from potyviral proteins to target GFP to the nucleus is examined. An essential modification of GFP is described, which specifically increases its molecular weight to eliminate its passive penetration into the nucleus. Three examples of the targeting of these enlarged GFP molecules to the nucleus are illustrated. GFP, in combination with confocal microscopy, offers significant advantages over traditional methods of studying nuclear targeting.
Analysis of the substrate specificity of tyrosylprotein sulfotransferase using synthetic peptides. (1990)

Tyrosylprotein sulfotransferase (TPST) catalyzes the sulfation of proteins at tyrosine residues. We have analyzed the substrate specificity of TPST from bovine adrenal medulla with a novel assay, using synthetic peptides as substrates. The peptides were modeled after the known, or putative, tyrosine sulfation sites of the cholecystokinin precursor, chromogranin B (secretogranin I) and vitronectin, as well as the tyrosine phosphorylation sites of alpha-tubulin and pp60src. Varying the sequence of these peptides, we found that (i) the apparent Km of peptides with multiple tyrosine sulfation sites decreased exponentially with the number of sites; (ii) acidic amino acids were the major determinant for tyrosine sulfation, acidic amino acids adjacent to the tyrosine being more important than distant ones; (iii) a carboxyl terminally located tyrosine residue may be sulfated. Moreover, TPST catalyzed the sulfation of a peptide corresponding to the tyrosine autophosphorylation site of pp60v-src (Tyr-416) but not of a peptide corresponding to the non-autophosphorylation site of pp60c-src (Tyr-527). These results experimentally define structural determinants for the substrate specificity of TPST and show that this enzyme and certain autophosphorylating tyrosine kinases have overlapping substrate specificities in vitro.
Spatial Sound Rendering Using Measured Room Impulse Responses (2006)

Spatial sound rendering has many applications such as music production, movies, electronic gaming and teleconferencing. Each of the applications may have different quality and complexity requirements. This paper presents a new spatial sound rendering framework that aims at producing realistic multichannel audio while being flexible and scalable so that is can be extended and adopted by various applications. The proposed framework uses multi-channel measured room impulse response (MMRIR) as the basis for building a room acoustic model which is used to synthesize multi-channel audio. The proposed framework has been evaluated by informal listening tests
Platelet-leukocyte interaction: selective binding of thrombin- stimulated platelets to human monocytes, polymorphonuclear leukocytes, and related cell lines (1986)

The association of platelets with leukocytes was investigated, using gel-filtered platelets stimulated with thrombin and then fixed with formaldehyde. Evidence is presented that stimulation of gel-filtered platelets with low concentrations of thrombin (0.01 to 0.1 U/mL) induces the expression of surface determinants interacting strongly with monocytes and polymorphonuclear leukocytes (PMNs) but only weakly with lymphocytes. Both monocyte-platelet binding and PMN-platelet binding occurred at 37 degrees C and more intensively at 0 degrees C; it was Ca2+-dependent and was unaffected by the addition of sodium azide. The binding also occurred with the monocytoid cell lines HL 60 and U 937 in exponential growth and was much less two days after induction of terminal differentiation by phorbol myristate acetate (PMA). No other tested cell lines (B cells, T cells, and myeloid cells) bound thrombin-stimulated platelets. Monocyte-derived macrophages kept in culture for one week also exhibited reduced binding of thrombin-stimulated platelets. IgG and fibronectin could be ruled out as ligands that mediate binding.
Vasopressin and Oxytocin in Stressa (1995)

Though oxytocin and vasopressin are similar in structure and are produced in the same brain regions, they show specific responses under stress conditions. In humans, increases in peripheral blood vasopressin appear to be a consistent finding during many acute stress situations, while in rats, vasopressin secretion is unresponsive to several stimuli known to induce ACTH and catecholamine release. Even decreases in vasopressin levels during stress were described. In accordance with others, we observed enhanced vasopressin release in response to stress stimuli with an osmotic component such as hypertonic saline injection but also during exposure of rats to a warm environment. Immobilization stress which fails to induce vasopressin release was reported to increase hypothalamic vasopressin mRNA and plasma vasopressin levels in chronically adreno-demedullated rats. Unlike vasopressin, oxytocin may be considered a typical stress hormone responding to osmotic as well as other stress stimuli. We found that acute exposure of rats to immobilization stress resulted in an increase in oxytocin mRNA level. In addition, we have shown that magnocellular neurons of the paraventricular nucleus, but not the supraoptic nucleus, are essential for oxytocin release during immobilization stress. The release of posterior pituitary hormones represents an important component of the stress response.
A channel-state-dependent bandwidth allocation scheme for integrated isochronous and bursty media data in a cellular mobile information system (2002)

We introduce a novel bandwidth allocation protocol for integrated wireless isochronous (e.g., voice) and bursty (e.g., file data) media data services on the uplink channel in a cellular mobile information system. The proposed protocol is TDMA based and the uplink frame is divided into two subframes: a request subframe and an information subframe. Our scheme, called CHARISMA (Channel Adaptive Reservation-based Isochronous Multiple Access), works by first gathering users' request via the mini-slots in the request subframe and then decides on the allocation of the information slots in the information subframe based on the channel states ranking of the mobile users. The merit of the CHARISMA protocol is that the precious bandwidth can be utilized more effectively because mobile terminals having good channel states can enjoy a higher throughput and a lower transmission error probability. The multiple access performance of the proposed MAC protocol is compared with traditional TDMA-based MAC algorithms.
Role of the Pressor Action of Angiotensin IIin Experimental Hypertension (1971)

Experiments with rabbit aortic strips and pithed rats indicated that 1-Sar-8-Ala-angiotensin II (Sar-Arg-Val-Tyr-Val-His-Pro-Ala) is a specific competitive antagonist of the vascular action of angiotensin II. Norepinephrine-induced hypertension was not affected by infusions of 1-Sar-8--Ala-angiotensin II which evoked a dose-related reduction of angiotensin II-induced hypertension in conscious rats. Infusions of 1-Sar-8-Ala-angiotensin II that caused a dose-related reduction of the blood pressure of conscious rats in the acute phase of unilateral renal hypertension were ineffective during the chronic phase of such hypertension. Infusions of 1-Sar-8-Ala-angiotensin II lasting 1 hour did not reduce the blood pressure of normotensive, spontaneously hypertensive, or metacorticoid hypertensive conscious rats. These data indicate that, under certain experimental conditions, the blood pressure of rats during the acute phase of unilateral renal hypertension is maintained hy the endogenous angiotensin II previously demonstrated to he present in the plasma in supernormal concentrations. The blood pressure of normotensive, spontaneously hypertensive, metacorticoid hypertensive, and chronic unilateral renal hypertensive rats previously shown to have normal plasma levels of renin and angiotensin II appeared to be independent of the pres.sor action of endogenous angiotensin II. This is additional direct evidence implicating the pressor action of angiotensin II in the etiology of renal hypertension.
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors (2003)

Functions of receptor tyrosine kinases implicated in angiogenesis were pharmacologically impaired in a mouse model of pancreatic islet cancer. An inhibitor targeting VEGFRs in endothelial cells (SU5416) is effective against early-stage angiogenic lesions, but not large, well-vascularized tumors. In contrast, a kinase inhibitor incorporating selectivity for PDGFRs (SU6668) is shown to block further growth of end-stage tumors, eliciting detachment of pericytes and disruption of tumor vascularity. Importantly, PDGFRs were expressed only in perivascular cells of this tumor type, suggesting that PDGFR(+) pericytes in tumors present a complimentary target to endothelial cells for efficacious antiangiogenic therapy. Therapeutic regimes combining the two kinase inhibitors (SU5416 and SU6668) were more efficacious against all stages of islet carcinogenesis than either single agent. Combination of the VEGFR inhibitor with another distinctive kinase inhibitor targeting PDGFR activity (Gleevec) was also able to regress late-stage tumors. Thus, combinatorial targeting of receptor tyrosine kinases shows promise for treating multiple stages in tumorigenesis, most notably the often-intractable late-stage solid tumor.
Biological function of the soluble CEACAM1 protein and implications in TAP2‐deficient patients (2004)

Interactions of natural killer (NK) cells with MHC class I proteins provide the main inhibitory signals controlling NK killing activity. It is therefore surprising to learn that TAP2-deficient patients suffer from autoimmune manifestations only occasionally in later stages of life. We have previously described that the CEACAM1-mediated inhibitory mechanism of NK cytotoxicity plays a major role in controlling NK autoreactivity in three newly identified TAP2-deficient siblings. This novel mechanism probably compensates for the lack of MHC class I-mediated inhibition. The CEACAM1 protein can also be present in a soluble form and the biological function of the soluble form of CEACAM1 with regard to NK cells has not been investigated. Here we show that the homophilic CEACAM1 interactions are abrogated in the presence of soluble CEACAM1 protein in a dose-dependent manner. Importantly, the amounts of soluble CEACAM1 protein detected in sera derived from the TAP2-deficient patients were dramatically reduced as compared to healthy controls. This dramatic reduction does not depend on the membrane-bound metalloproteinase activity. Thus, the expression of CEACAM1 and the absence of soluble CEACAM1 observed in the TAP2-deficient patients practically maximize the inhibitory effect and probably help to minimize autoimmunity in these patients.
Effect of Long-Term Treatment with Selective Vasopressin V1 and V2 Receptor Antagonist on the Development of Heart Failure in Rats (1996)

Vasopressin has been implicated in the pathogenesis of heart failure as one of the most potent vasoconstrictors. However, whether the increase in plasma vasopressin levels modifies the pathophysiology of heart failure remains unknown. To investigate the effect of long-term inhibition of vasopressin in the development of heart failure, we administered a selective, orally effective, nonpeptide vasopressin antagonist, the V1 receptor antagonist OPC-21268 (100 mg center dot kg-1 center dot day-1) or a V2 receptor antagonist, OPC-31260 (20 mg center dot kg-1 center dot day-1) to rats with heart failure induced by the creation of an aortocaval fistula (AVF) and to sham-operated rats for 4 weeks, beginning on the first postoperative day. The heart failure in this experiment was characterized by an increase in the weights of the right and left ventricles, the lungs, and the right and left appendage, increase in left ventricular end-diastolic pressure (LVEDP), increase in right ventricular systolic pressure (RVSP), increase in right atrial pressure (RAP), and an increase in the plasma level of atrial natriuretic peptide (ANP) as compared with no change in sham-operated rats. There were no differences in shunt ratio between treated and untreated heart failure groups. Chronic administration of the V2 receptor antagonist OPC-31260 significantly reduced the weight of the right ventricle (1.17 +/- 0.39 vs. 0.90 +/- 0.13 g/kg, p < 0.05), RVSP (53 +/- 18 vs. 39 +/- 4 mm Hg, p < 0.05), LVEDP (11.8 +/- 5.2 vs. 6.5 +/- 2.8 mm Hg, p < 0.05) and the plasma concentrations of ANP (554 +/- 271 vs. 193 +/- 39 pg/ml, p < 0.05) as compared with the values of rats with untreated HF. Chronic treatment with the V1 receptor antagonist OPC-21268 did not alter hemodynamics, organ weights, or hormone concentrations. These results suggest that vasopressin did not contribute mainly to the maintenance of systemic hemodynamics through the V1 receptor in this heart failure model. Vasopressin may play a role, at least in part, in the fluid retention in the development of heart failure through the V2 receptor. OPC-31260 may present a new approach to the treatment of heart failure.
Linear image coding for regression and classification using the tensor-rank principle (2005)

Given a collection of images (matrices) representing a "class" of objects we present a method for extracting the commonalities of the image space directly from the matrix representations (rather than from the vectorized representation which one would normally do in a PCA approach, for example). The general idea is to consider the collection of matrices as a tensor and to look for an approximation of its tensor-rank. The tensor-rank approximation is designed such that the SVD decomposition emerges in the special case where all the input matrices are the repeatition of a single matrix. We evaluate the coding technique both in terms of regression, i.e., the efficiency of the technique for functional approximation, and classification. We find that for regression the tensor-rank coding, as a dimensionality reduction technique, significantly outperforms other techniques like PCA. As for classification, the tensor-rank coding is at is best when the number of training examples is very small.
Design for Resilience to Soft Errors and Variations (2007)

This paper presents adaptive variation-and-error-resilient agent (AVERA), an approach to address the challenge of designing reliable systems in the presence of soft errors and variations. AVERA extends our previous built-in soft error resilience (BISER) approach by adding additional capabilities to support process variation diagnosis, degradation detection, and system adaptation, besides soft error correction. We also discuss open challenges for building variation-and-error-resilient systems.
Trade Show Fundraiser (2013)

There are over 13,000 events in the United States each year with at least 3,000 net square feet of exhibit space per event. Trade shows are big business, so it's no surprise that savvy companies and causes are working together to raise money and make a difference.
Orofacial infection of athymic mice with defined mixtures of acyclovir-susceptible and acyclovir-resistant herpes simplex virus type 1 (1989)

Infection of athymic mice with defined populations of acyclovir-susceptible (thymidine kinase [TK]-positive) and acyclovir-resistant (TK-deficient or TK-altered) herpes simplex virus type 1 strains was used to simulate herpetic skin disease of the immunocompromised host. In vitro characterization of the defined virus mixtures revealed that the dye uptake method was quite sensitive in the detection of small amounts (3 to 9%) of acylovir-resistant virus. Mice infected with homogeneous virus populations exhibited a good correlation between clinical response and the in vitro drug susceptibility of the infecting virus. Animals infected with defined mixtures of viruses exhibited varied patterns of infection and responses to acyclovir treatment. However, disease severity was useful in predicting the TK phenotype of virus recovered from lesions. Pathogenic, TK-altered virus was responsible for progressive disease in animals receiving low-dose (0.25-mg/ml) prophylactic acyclovir or high-dose (1.25-mg/ml) delayed therapy. Although this mutant was recovered infrequently, it was responsible for clinically significant disease in the animals from which it was isolated.
Analysis of GPS and Loran-C performance for land vehicle navigation in the Canadian Rockies (1992)

Loran-C and GPS were assessed for vehicular navigation along selected roads of British Columbia during the winter of 1991. The general topography of this mountainous area is described, together with the specific topographic features and tree coverage characteristics of the 2000 km of roads tested on the mainland and on Vancouver Island. The configuration and characteristics of the Loran C Canadian West Coast chain along the roads used are described. The portable vehicle-mounted system used to collect and analyze the Loran-C and GPS signals along road profiles is described. The performance of Loran-C is analyzed in terms of signal to noise ratios (SNR), field strength, and time-difference distortions, as measured by differential GPS. These distortions, which can reach several hundred meters over distances of less than 20 km, are analyzed in terms of topographic features. The possibility of using these time-independent distortions to calibrate Loran-C for use along the above roads is discussed. Masking of GPS signals due to topographic features and tree coverage along the roads is analyzed. A comparative analysis of both Loran-C and GPS is presented in terms of signal availability and accuracy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>