gebhart/patrepeval huggingface dataset:
Derivatives of 3,4-dihydroxyphenylalanine for peptide synthesis (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDerivatives of 3,4-dihydroxyphenylalanine for peptide synthesisSome N. Banerjee and Charlotte ResslerCite this: J. Org. Chem. 1976, 41, 18, 3056–3058Publication Date (Print):September 1, 1976Publication History Published online1 May 2002Published inissue 1 September 1976https://pubs.acs.org/doi/10.1021/jo00880a040https://doi.org/10.1021/jo00880a040research-articleACS PublicationsRequest reuse permissionsArticle Views318Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Long-length Y-Ba-Cu-O coated conductors produced by surface-oxidation epitaxy method (2001)

A 50-m long, biaxially textured NiO buffer layer for epitaxial growth of YBa/sub 2/Cu/sub 3/O/sub 7-/spl delta//(YBCO) film has been fabricated on a long length cube-textured Ni tape using the surface-oxidation epitaxy (SOE) technique. The thickness of NiO layer was arranged to be around 3 /spl mu/m. The tape manufacturing speed was 15 m/h, The SOE-NiO layer was highly [100] oriented and the full width at half maximum from the X-ray /spl phi/-scan for NiO(111) was varied from 13 to 19 degrees in the whole length. J/sub c/ values exceeding 0.3 MA/cm/sup 2/ at 77 K and self field have been obtained in short samples of YBCO films on NiO/Ni tapes, by using a thin MgO cap layer with the thickness of about 100 nm. Crystal orientation control of YBCO coated conductors by the SOE method is very effective even for the long length Ni tapes.
A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates (2013)

Iron maldistribution has been implicated in the etiology of many diseases including the anemia of inflammation (AI), atherosclerosis, diabetes, and neurodegenerative disorders. Iron metabolism is controlled by hepcidin, a 25-amino-acid peptide. Hepcidin is induced by inflammation and causes iron to be sequestered within cells of the reticuloendothelial system, suppressing erythropoiesis and blunting the activity of erythropoiesis stimulating agents (ESAs). For this reason, neutralization of hepcidin has been proposed as a therapeutic treatment of AI. The aim of the current work was to generate fully human anti-hepcidin antibodies (Abs) as a potential human therapeutic for the treatment of AI and other iron maldistribution disorders. An enzyme-linked immunosorbent assay was established using these Abs to identify patients likely to benefit from either ESAs or anti-hepcidin agents. Using human hepcidin knock-in mice, the mechanism of action of the Abs was shown to be due to an increase in available serum iron leading to enhanced red cell hemoglobinization. One of the Abs, 12B9m, was validated in a mouse model of AI and demonstrated to modulate serum iron in cynomolgus monkeys. The 12B9m Ab was deemed to be an appropriate candidate for use as a potential therapeutic to treat AI in patients with kidney disease or cancer.
The Viral Diseases of Fish: A Review Through 1978: Part 1: Diseases of Proven Viral Etiology (1980)

In this review, a survey is made of the published literature on the viral diseases of fish available up to and including the year 1978. It is divided into two main sections. Part 1 describes 11 diseases where a virus has been isolated and proven to be the causative agent. Part 2 discusses 16 diseases where there is reason to suspect viral etiology because of evidence deriving from electron microscopy or transmission experiments with bacteria-free filtrates of homogenates of diseased tissue, but where final proof of a causative relationship is lacking. The review attempts to provide the most significant information on the disease process itself, in most cases including external signs, fish species susceptible, pathology, geographic distribution, existence of carriers, methods of transmission, and control. It also gives the most recent and significant data concerning the nature of the causative virus, including its cultural, biological, and physicochemical properties, where such information is available.
β3 Integrin in Cardiac Fibroblast Is Critical for Extracellular Matrix Accumulation during Pressure Overload Hypertrophy in Mouse (2012)

The adhesion receptor β3 integrin regulates diverse cellular functions in various tissues. As β3 integrin has been implicated in extracellular matrix (ECM) remodeling, we sought to explore the role of β3 integrin in cardiac fibrosis by using wild type (WT) and β3 integrin null (β3-/-) mice for in vivo pressure overload (PO) and in vitro primary cardiac fibroblast phenotypic studies. Compared to WT mice, β3-/- mice upon pressure overload hypertrophy for 4 wk by transverse aortic constriction (TAC) showed a substantially reduced accumulation of interstitial fibronectin and collagen. Moreover, pressure overloaded LV from β3-/- mice exhibited reduced levels of both fibroblast proliferation and fibroblast-specific protein-1 (FSP1) expression in early time points of PO. To test if the observed impairment of ECM accumulation in β3-/- mice was due to compromised cardiac fibroblast function, we analyzed primary cardiac fibroblasts from WT and β3-/- mice for adhesion to ECM proteins, cell spreading, proliferation, and migration in response to platelet derived growth factor-BB (PDGF, a growth factor known to promote fibrosis) stimulation. Our results showed that β3-/- cardiac fibroblasts exhibited a significant reduction in cell-matrix adhesion, cell spreading, proliferation and migration. In addition, the activation of PDGF receptor associated tyrosine kinase and non-receptor tyrosine kinase Pyk2, upon PDGF stimulation were impaired in β3-/- cells. Adenoviral expression of a dominant negative form of Pyk2 (Y402F) resulted in reduced accumulation of fibronectin. These results indicate that β3 integrin-mediated Pyk2 signaling in cardiac fibroblasts plays a critical role in PO-induced cardiac fibrosis.
Alternative splicing of the human PTEN/MMAC1/TEP1 gene (2000)

The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns.
Differences between the effects of thyroxine and tetraiodothyroacetic acid on TSH suppression and cardiac hypertrophy (2001)

We postulate therefore that, in the rat and possibly in man, Tetrac could represent a favorable alternative for suppression of serum TSH levels.
Immunization by selective infection with type 4 adenovirus grown in human diploid tissue cultures. I. Safety and lack of oncogenicity and tests for potency in volunteers. (1966)

Numerous studies have shown that adenovirus infection constitutes a major cause of acute febrile respiratory-tract disease in military recruits. 1,2 Most recruit adenovirus infections are produced by type 4 virus, and to a lesser extent by types 3 and 7 viruses. The impact of adenovirus infection on recruit populations is large in terms of high respiratory-tract disease morbidity, hospitalization, and costly disruption of military training. 3 For this reason there is an urgent need for effective immunoprophylaxis. The first experimental inactivated adenovirus vaccines prepared in monkey-kidney tissue culture were extremely effective in preventing adenovirus disease. 4,5 However, subsequent production lots of similar vaccines exhibited a variable degree of potency. In some instances very little protection was conferred. 3 In addition there has been considerable difficulty in producing adenovirus vaccines which are free of simian virus contamination. The most troublesome of the simian viruses has been simian virus 40 (SV 40).
Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches (2017)

Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), molecular approaches have recently emerged as relevant alternatives in routine laboratories. Here, we evaluated the use of two different amplicon-based next-generation sequencing (NGS) methods (AmpliSeq and Archer<sup>®</sup>FusionPlex<sup>®</sup>) to detect ALK rearrangements, and compared these with IHC and FISH. A total of 1128 NSCLC specimens were screened using conventional analyses, and a subset of 37 (15 ALK-positive, and 22 ALK-negative) samples were selected for NGS assays. Although AmpliSeq correctly detected 25/37 (67.6%) samples, 1/37 (2.7%) and 11/37 (29.7%) specimens were discordant and uncertain, respectively, requiring further validation. In contrast, Archer<sup>®</sup>FusionPlex<sup>®</sup> accurately classified all samples and allowed the correct identification of one rare DCTN1-ALK fusion, one novel CLIP1-ALK fusion, and one novel GCC2-ALK transcript. Of particular interest, two out of three patients harboring these singular rearrangements were treated with and sensitive to crizotinib. These data show that Archer<sup>®</sup>FusionPlex<sup>®</sup> may provide an effective and accurate alternative to FISH testing for the detection of known and novel ALK rearrangements in clinical diagnostic settings.
Use of pIRES Vectors to Express EGFP and Connexin Constructs in Studies of the Role of Gap Junctional Communication in the Early Development of the Chick Retina and Brain (2001)

Control of cell proliferation is vital for the normal development of the neural retina. Gap junctional communication has been implicated in the control of retinal cell proliferation. We have previously shown that the expression of the gap junction protein Connexin 43 closely correlates with the first wave of cell proliferation in the retina. Preventing its expression using antisense oligonucleotides in the developing eye and surrounding tissues, produces a reduction in cell number and the formation of a small eye. In order to examine this in more detail we have developed a new means of manipulating connexin expression in the developing chick embryo. We have generated pIRES vectors which use cyclomegalovirus (CMV) to promote the expression of a green fluorescent protein (EGFP) and either wild type Cx43 or a dominant negative form ofthis connexin. Following injection ofthese constructs into the ventricles ofthe stage 10-11 chick embryo they can be incorporated into one side of the chick brain or optic vesicle using an electroporation technique, leaving the other side as a control. EGFP expression can be seen on the electroporated side of the chick brain within 24 hours. Expression of the dominant negative construct in cultures of chick limb bud mesenchyme results in total block of cascade blue transfer when injected into transfected cells. Expression of both wild type and dominant negative constructs in the developing chick retina perturbs the normal development of the eye.
The expanding world of hybrid perovskites: materials properties and emerging applications (2015)

Abstract Hybrid inorganic–organic perovskites have emerged over the last 5 years as a promising class of materials for optoelectronic applications. Most notably, their solar cells have achieved power conversion efficiencies above 20% in an unprecedented timeframe; however, many fundamental questions still remain about these materials. This Prospective Article reviews the procedures used to deposit hybrid perovskites and describes the resulting crystallographic and morphological structures. It further details the electrical and optical properties of perovskites and then concludes by highlighting a number of potential applications and the materials challenges that must be overcome before they can be realized.
How corticosteroids control inflammation: Quintiles Prize Lecture 2005 (2006)

Corticosteroids are the most effective anti-inflammatory therapy for many chronic inflammatory diseases, such as asthma but are relatively ineffective in other diseases such as chronic obstructive pulmonary disease (COPD). Chronic inflammation is characterised by the increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as nuclear factor-kappaB and activator protein-1, that bind to and activate coactivator molecules, which then acetylate core histones to switch on gene transcription. Corticosteroids suppress the multiple inflammatory genes that are activated in chronic inflammatory diseases, such as asthma, mainly by reversing histone acetylation of activated inflammatory genes through binding of liganded glucocorticoid receptors (GR) to coactivators and recruitment of histone deacetylase-2 (HDAC2) to the activated transcription complex. At higher concentrations of corticosteroids GR homodimers also interact with DNA recognition sites to active transcription of anti-inflammatory genes and to inhibit transcription of several genes linked to corticosteroid side effects. In patients with COPD and severe asthma and in asthmatic patients who smoke HDAC2 is markedly reduced in activity and expression as a result of oxidative/nitrative stress so that inflammation becomes resistant to the anti-inflammatory actions of corticosteroids. Theophylline, by activating HDAC, may reverse this corticosteroid resistance. This research may lead to the development of novel anti-inflammatory approaches to manage severe inflammatory diseases.
Effects of soiling on PV module and radiometer performance (2002)

The question of "how much does the output of PV modules and radiometers decrease due to soiling?" is often asked, but data are rarely available to answer the question. Related questions are: a) how effectively does rain clean soiled devices; and b) how often should radiometers and modules be cleaned? Answers to these questions are essential to predict PV module performance or the accuracy (uncertainty) of PV module performance data. Results of module and radiometer soiling data from three independent applications are presented in this paper. Data cover soiling periods from 16 months to five years, and results are consistent for all three applications.
Long-term potentiation of thalamic input to the motor cortex induced by coactivation of thalamocortical and corticocortical afferents (1991)

1. Intracellular recordings were obtained from neurons in the motor cortex (MCx), in which excitatory postsynaptic potentials (EPSPs) were evoked by microstimulation of the somatosensory cortex (SCx) and the ventrolateral nucleus (VL) of the thalamus. The effects of combined tetanic stimulation of SCx and VL on the amplitudes of these EPSPs were studied. 2. Amplitudes of both corticocortical (CC) and thalamocortical (TC) EPSPs were potentiated after combined tetanic stimulation. This potentiation occurred exclusively in neurons that were located in the superficial layers (II/III) and that received direct input from both the SCx and VL, with both inputs synapsing in close proximity to each other. In all cases, the potentiation lasted until the electrode went out of the cell (21 +/- 25 min, mean +/- SD) the longest being 90 min. We therefore refer to this potentiation as long-term potentiation (LTP). 3. Tetanic stimulation of the thalamus only did not produce LTP in neurons receiving direct input from the VL. 4. LTP was not induced in either CC or TC EPSPs in neurons located in layer V and/or in neurons receiving long-latency CC EPSPs. 5. It is concluded that TC input from the VL to the MCx is potentiated only when coactivated with the CC input from the SCx.
Toward in vivo mobility. (2005)

Today's laparoscopic tools impose severe ergonomic limitations and are constrained to only four degrees of freedom. These constraints limit the surgeon's ability to orient the tool tips arbitrarily, and can contribute to a variety of complications. Robots external to the patient have been used to aid in the manipulation of the tools and improve dexterity. However, these robots are expensive, bulky, and are used for only select procedures. In vivo robotic assistants have the potential to enhance the capabilities of the surgeon, reduce costs, and reduce patient trauma. The motion of these in vivo robots will not be constrained by the insertion incisions. Such assistants will need to attain optimal viewing angles by traversing the abdominal organs without causing trauma. This paper presents an experimental analysis of miniature in vivo robot wheels.
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits (2015)

Over the past decade, increasing evidence has implied a significant connection between caspase-6 activity and the pathogenesis of Huntington's disease (HD). Consequently, inhibiting caspase-6 activity was suggested as a promising therapeutic strategy to reduce mutant Huntingtin toxicity, and to provide protection from mutant Huntingtin-induced motor and behavioral deficits. Here, we describe a novel caspase-6 inhibitor peptide based on the huntingtin caspase-6 cleavage site, fused with a cell-penetrating sequence. The peptide reduces mutant Huntingtin proteolysis by caspase-6, and protects cells from mutant Huntingtin toxicity. Continuous subcutaneous administration of the peptide protected pre-symptomatic BACHD mice from motor deficits and behavioral abnormalities. Moreover, administration of the peptide in an advanced disease state resulted in the partial recovery of motor performance, and an alleviation of depression-related behavior and cognitive deficits. Our findings reveal the potential of substrate-based caspase inhibition as a therapeutic strategy, and present a promising agent for the treatment of HD.
Reduction of Some Oxindolylidene Derivatives to 3-Substituted Oxindoles by Sodium Borohydride1 (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of Some Oxindolylidene Derivatives to 3-Substituted Oxindoles by Sodium Borohydride1I. W. Elliott and P. RiversCite this: J. Org. Chem. 1964, 29, 8, 2438–2440Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://pubs.acs.org/doi/10.1021/jo01031a502https://doi.org/10.1021/jo01031a502research-articleACS PublicationsRequest reuse permissionsArticle Views255Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silencing ?1,2-xylosyltransferase in Transgenic Tomato Fruits Reveals xylose as Constitutive Component of Ige-Binding Epitopes (2011)

Complex plant N-glycans containing β1,2-xylose and core α1,3-fucose are regarded as the major class of the so-called "carbohydrate cross-reactive determinants" reactive with IgE antibodies in sera of many allergic patients, but their clinical relevance is still under debate. Plant glycosyltransferases, β1,2-xylosyltransferase (XylT), and core α1,3-fucosyltransferase (FucT) are responsible for the transfer of β1,2-linked xylose and core α1,3-linked fucose residues to N-glycans of glycoproteins, respectively. To test the clinical relevance of β1,2-xylose-containing epitopes, expression of the tomato β1,2-xylosyltransferase was down-regulated by RNA interference (RNAi) in transgenic plants. Fruits harvested from these transgenic plants were analyzed for accumulation of XylT mRNA, abundance of β1,2-xylose epitopes and their allergenic potential. Based on quantitative real-time PCR analysis XylT mRNA levels were reduced up to 10-fold in independent transgenic lines as compared to untransformed control, whereas no xylosylated N-glycans could be revealed by MS analysis. Immunoblotting using anti-xylose-specific IgG antibodies revealed a strong reduction of β1,2-xylose-containing epitopes. Incubating protein extracts from untransformed controls and XylT_RNAi plants with sera from tomato allergic patients showed a patient-specific reduction in IgE-binding, indicating a reduced allergenic potential of XylT_RNAi tomato fruits, in vitro. To elucidate the clinical relevance of β1,2-xylose-containing complex N-glycans skin prick tests were performed demonstrating a reduced responsiveness of tomato allergic patients, in vivo. This study provides strong evidence for the clinical relevance of β1,2-xylose-containing epitopes in vivo.
A Quantitative Measure of the Mitotic Pairing of Alleles in Drosophila melanogaster and the Influence of Structural Heterozygosity (1996)

In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements can alter the phenotype produced by a pair of alleles. It is thought that heterozygous rearrangements impede the ability of alleles to pair and interact. However, because the existing data are inconsistent, this issue is not fully settled. By measuring the frequency of site-specific recombination between homologous chromosomes, we show that structural heterozygosity inhibits the pairing of alleles that lie distal to a rearrangement breakpoint. We suggest that some of the apparent conflicts may owe to variations in cell-cycle lengths in the tissues where the relevant allelic interactions occur. Cells with a longer cell cycle have more time to establish the normal pairing relationships that have been disturbed by rearrangements. In support, we show that Minute mutations, which slow the rate of cell division, partially restore a transvection effect that is disrupted by inversion heterozygosity.