gebhart/patrepeval huggingface dataset:
Image Guided Navigation System to Measure Intraoperatively Acetabular Implant Alignment (1998)

There has been little clinical research to examine the effects of patient positioning and pelvic motion on the alignment of the acetabular implant during total hip replacement surgery. Until now, no tools were capable of accurately measuring these variables during the actual procedure. As part of a broader program in medical robotics and computer assisted surgery, a clinical system has been developed that includes several enabling technologies. The hip navigation system (HipNav) continuously and precisely measures pelvic location and tracks relative implant alignment intraoperatively. HipNav technology is used to gauge current clinical practice and provide intraoperative feedback to surgeons with the goal of improving the precision and accuracy of acetabular alignment during total hip replacement. This system provides surgeons with a new class of image guided measurement tools and assist devices. These tools successfully were introduced into the clinical practice of surgery with results showing the following: (1) There exist unpredictable and large variations in the initial position of patients' pelves on the operating room table and significant pelvic movement during surgery and during intraoperative range of motion testing; (2) current mechanical acetabular alignment guides do not account for these variations, and result in variable and in the majority of cases unacceptable acetabular alignment; and (3) press fitting oversized acetabular components influences the final cup orientation.
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension (1990)

Endothelium-mediated vasodilation is impaired in patients with essential hypertension. This defect may play an important part in the functional abnormalities of resistance vessels that are observed in hypertensive patients.
Developing Transferrable Geospatial Skills in a Liberal Arts Context (2011)

Geology education usually takes place within the context of a broader curriculum, but specific synergies between disciplines have rarely been explored or exploited. Here, we have assessed the spatial visualization skills of undergraduate students in a variety of disciplines to determine which are most compatible with a geology curriculum. Spatial abilities are considered one of the most important cognitive skills in the geosciences but there has been little comparative work among disciplines (and particularly non-Science, Technology, Engineering and Mathematics disciplines). Our results demonstrate that geology students had the highest average spatial test scores (a mean of 16.4 out of a possible 20) among the 11 disciplines assessed, and this remained true even after correcting for the effects of gender and grade point average. Both physics and fine arts students also performed well on this assessment. A major implication of our study is that geology students can deliberately enhance their spatial abilities by taking courses in other fields, such as the fine arts, which are known to build those same abilities. In this way, geology curricula may be developed to maximize the benefits of a broad education and thus, ultimately, produce higher-performing geologists.
Effects of Magnesium Supplementation in a Porcine Model of Myocardial Ischemia and Reperfusion (1994)

We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2+) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregation would be elicited. An open-chest model was used, with transient occlusion of the left anterior descending coronary artery (LAD) for 8 min. Regional contractile function was assessed by measuring wall thickening fraction with epicardial Doppler crystals. One control group (n = 6) and two treatment groups were studied: group I (n = 6) received 750 mg MgSO4 before occlusion; group II (n = 6) received 1 g MgSO4 after the occlusion. Both protocols produced significant hypermagnesemia. In group I, platelet aggregation was measured before and after Mg2+ treatment using platelet-rich plasma (PRP) and various agonists (ADP 5 and 10 mM and collagen 1 mg/ml). As compared with controls, both treatment groups experienced significantly less postischemic dysfunction, with systolic function returning more quickly to baseline. Furthermore, platelet aggregation was significantly decreased immediately after Mg2+ infusion. Inhibition of platelet aggregation induced by Mg2+ treatment occurs concomitantly with significant amelioration of postischemic myocardial dysfunction.
Cytotoxic Geranyl Stilbenes from Macaranga schweinfurthii (1998)

Three novel geranyl stilbenes, schweinfurthins A, B, and C (1, 2, and 3), were isolated from the Cameroonian plant Macaranga schweinfurthii (Euphorbiaceae) and their structures determined by NMR and mass spectral methods. The cytotoxicity profile of the schweinfurthins tested in the NCI 60-cell screen was similar to that of the stelletins and cephalostatins, suggesting that these structurally diverse natural products may share similar mechanisms of cytotoxicity.
동남권 지역혁신을 위한 혁신클러스터 해외선진사례연구 - 미국의 Research Triangle Park을 중심으로 (2006)

본 연구의 목적은 부산·울산·경남지역을 포괄하는 동남경제권의 새로운 경제성장전략인 지역혁신시스템구축과 성공적인 혁신클러스터 형성을 위하여 미국의 노스캐롤라이나주의 Research Triangle Park(RTP)의 성공사례를 분석하여 정책적 시사점을 제시함으로써 지역경제발전을 위한 정책수립에 오류를 최소화하고 실패를...
Resonantly enhanced transmission of terahertz radiation through a periodic array of subwavelength apertures (2004)

We demonstrate resonantly enhanced transmission of freely propagating coherent terahertz radiation through free-standing metal foils perforated with periodic arrays of sub-wavelength apertures. These arrays consist of 400 microm diameter apertures periodically spaced by 1 mm and 600 microm diameter apertures periodically spaced by 1.5 mm. We measure absolute amplitude transmission coefficients of ~0.6 at the resonance wavelength. Correspondingly, the ratio of the absolute amplitude transmission coefficient to the fractional aperture area at these resonance frequencies is ~5. This value at terahertz frequencies is significantly larger than equivalent values measured at optical frequencies.
Dendritic epidermal T-cell involvement in induction of CD8+ T cell-mediated immunity against an ultraviolet radiation-induced skin tumor (1997)

Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate the roles of these epidermal cells (EC) in protective antitumor immunity, an in vivo model of an ultraviolet radiation-induced fibrosarcoma, UV-13-1, was used. Mice were immunized with tumor antigen-pulsed EC followed 10 days later by an injection into the ear of 10(5) tumor cells, which did not lead to formation of a detectable tumor, but was intended to simulate the influence of a developing tumor on the ensuing immune response. The mice were then challenged with 2 x 10(6) viable tumor cells in each flank, sufficient to result in growth of a measurable tumor. Protective immunity was induced by DETC, and shown to be long-lasting, with tumors inoculated 160 days after immunization being effectively rejected. The effector cells responsible for protective immunity were CD8+ T cells. Delayed-type hypersensitivity generated by tumor antigen-pulsed EC was dependent on LCs, with no involvement of DETCs. This response, in contrast to that of DETC, required prior culture of EC with GM-CSF, but failed to inhibit tumor growth or incidence. Thus DETC and LC can both activate antitumor immune responses, although only the DETC-dependent response results in protective immunity in the presence of a developing tumor.
Activation of casein kinase II in ML-1 human myeloblastic leukemia cells requires IGF-1 and transferrin (1995)

Casein kinase II (CK II), a key enzyme involved in the regulation of cell growth, has been variously reported to be activated by diverse mitogens, including insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF). Activation of the enzyme is generally carried out in the presence of serum, and we examined the question whether serum components participate in the activation process. We demonstrated previously that ML-1 cells require IGF-1 plus transferrin (TF) for growth and transforming growth factor beta or tumor necrosis factor alpha plus TF for differentiation. We now found that CK II is activated only when the cells are exposed to both IGF-1 and TF or when TF is replaced in this combination with relatively high levels of iron salts. Induction of differentiation with TGF-beta and TF did not result in CK II activation. These results show that CK II activation in ML-1 cells requires the application of both components of the growth signal, IGF-1 and TF, demonstrating that the growth factor alone is incapable of enhancing the activity of the enzyme.
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases (2010)

Gene targeting by homologous recombination in embryonic stem cells is extensively used to generate specific mouse mutants. However, most mammalian species lack tools for targeted gene manipulation. Since double-strand breaks strongly increase the rate of homologous recombination at genomic loci, we explored whether gene targeting can be directly performed in zygotes by the use of zinc-finger nucleases. Here we report that gene targeting is achieved in 1.7-4.5% of murine one-cell embryos upon the coinjection of targeting vectors with zinc-finger nucleases, without preselection. These findings enable the manipulation of the mammalian germ line in a single step in zygotes, independent of ES cells.
Level of Maternal Antibody Required to Protect Neonates against Early‐Onset Disease Caused by Group B Streptococcus Type Ia: A Multicenter, Seroepidemiology Study (2001)

Because of the difficulty of conducting efficacy trials of vaccines against group B streptococcus (GBS), the licensure of these vaccines may have to rely on studies that measure vaccine-induced antibody levels that correlate with protection. This study estimates the level of maternal antibody required to protect neonates against early-onset disease (EOD) caused by GBS type Ia. Levels of maternal serum IgG GBS Ia antibodies, measured by ELISAs in 45 case patients (neonates with EOD caused by GBS Ia) and in 319 control subjects (neonates colonized by GBS Ia but without EOD) born at > or =34 weeks gestation were compared. The probability of developing EOD declined with increasing maternal levels of IgG GBS Ia antibody (P = .03). Neonates whose mothers had levels of IgG GBS Ia antibody > or =5 microg/mL had an 88% lower risk (95% confidence interval, 7%-98%) of developing type-specific EOD, compared with those whose mothers had levels < 0.5 microg/mL. A vaccine that induces IgG GBS Ia antibody levels > or =5 microg/mL in mothers can be predicted to confer a high degree of type-specific immunity to EOD to their infants.
Laser desorption time-of-flight mass spectrometry of high mass molecules (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLaser desorption time-of-flight mass spectrometry of high mass moleculesJean Claude. Tabet and Robert J. CotterCite this: Anal. Chem. 1984, 56, 9, 1662–1667Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ac00273a028https://doi.org/10.1021/ac00273a028research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Comparative effects of continuous infusion of mCPP, Ro 60‐0175 and d‐fenfluramine on food intake, water intake, body weight and locomotor activity in rats (2000)

1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats. 2. Chronic infusion of all three drugs significantly reduced food intake and attenuated body weight gain. In contrast, drug infusion did not lead to significant reductions in locomotor activity in animals assessed 2 and 13 days after pump implantation. 3. In a subsequent 14 day study that was designed to identify possible tolerance during days 7 - 14, animals were given a subcutaneous infusion of mCPP (12 mg kg(-1) day(-1)) or d-fenfluramine (6 mg kg(-1) day(-1)) for either 7 or 14 days. During the first 7 days both drugs significantly reduced body weight gain compared to saline-infused controls; however, from day 7 onwards animals withdrawn from drug treatment exhibited an increase in body weight such that by day 14 they were significantly heavier than their 14-day drug-treated counterparts. 4. Both mCPP and d-fenfluramine reduced daily food intake throughout the infusion periods. For 14-day treated animals this hypophagia was marked during the initial week of the study but only minor during the second week. In light of the sustained drug effect on body weight, the data suggest that weight loss by 5-HT(2C) receptor stimulation may be only partly dependent on changes in food consumption and that 5-HT(2C) receptor agonists may have effects on thermogenesis. 5. These data suggest tolerance does not develop to the effects of d-fenfluramine, mCPP and Ro 60-0175 on rat body weight gain.
Fluorescence Resonance Energy Transfer as a Probe for G-Quartet Formation by a Telomeric Repeat (2001)

The secondary structure of guanine-rich oligodeoxynucleotides has been investigated with fluorescent probes. Intramolecular folding of a telomeric oligonucleotide into a quadruplex led to fluorescence resonance energy transfer (FRET) between a donor (fluorescein) and an acceptor (tetramethylrhodamine) covalently attached to the 5' and 3' ends of the DNA, respectively. Depending on oligonucleotide length, quenching efficiency varied between 0.45 and 0.72 at 20 degrees C. The conjugation of the dyes to the oligonucleotide had a limited, but significant, influence on the thermodynamics of G-quartet formation. Intramolecular folding was demonstrated from the concentration independence of fluorescence resonance energy transfer over a wide concentration range. Folding of the oligonucleotide was confirmed by UV absorption, UV melting, and circular dichroism experiments. The folding of the G-quartet could be followed at concentrations as low as 100 pM. Fluorescence resonance energy transfer can thus be used to reveal the formation of multistranded DNA structures.
Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer (2010)

Rare circulating tumor cells (CTCs) are present in the blood of patients with metastatic epithelial cancers but have been difficult to measure routinely. We report a quantitative automated imaging system for analysis of prostate CTCs, taking advantage of prostate-specific antigen (PSA), a unique prostate tumor-associated marker. The specificity of PSA staining enabled optimization of criteria for baseline image intensity, morphometric measurements, and integration of multiple signals in a three-dimensional microfluidic device. In a pilot analysis, we detected CTCs in prostate cancer patients with localized disease, before surgical tumor removal in 8 of 19 (42%) patients (range, 38 to 222 CTCs per milliliter). For 6 of the 8 patients with preoperative CTCs, a precipitous postoperative decline (<24 hours) suggests a short half-life for CTCs in the blood circulation. Other patients had persistent CTCs for up to 3 months after prostate removal, suggesting early but transient disseminated tumor deposits. In patients with metastatic prostate cancer, CTCs were detected in 23 of 36 (64%) cases (range, 14 to 5000 CTCs per milliliter). In previously untreated patients followed longitudinally, the numbers of CTCs declined after the initiation of effective therapy. The prostate cancer-specific TMPRSS2-ERG fusion was detectable in RNA extracted from CTCs from 9 of 20 (45%) patients with metastatic disease, and dual staining of captured CTCs for PSA and the cell division marker Ki67 indicated a broad range for the proportion of proliferating cells among CTCs. This method for analysis of CTCs will facilitate the application of noninvasive tumor sampling to direct targeted therapies in advanced prostate cancer and warrants the initiation of long-term clinical studies to test the importance of CTCs in invasive localized disease.
The Zeiss-MKM system for frameless image-guided approach in epidural motor cortex stimulation for central neuropathic pain (2001)

Since intraoperative SSEP monitoring has, for many years, been considered the standard procedure to approach motor target, the development of an accurate stereotactic image guidance system could help to increase the efficacy of MCS on the alleviation of pain. The excellent spatial accuracy provided by the Zeiss-MKM navigation system allows precise data correlations that represent a remarkable means to validate functional MR imaging as an alternative to SSEP. The authors believe that developing stereotactic image guidance with such a navigation system could improve the success rate of MCS.
Enhanced Photovoltaic Performance of Low‐Bandgap Polymers with Deep LUMO Levels (2010)

Mind the gap! Polymers synthesized by replacing the benzene unit in the acceptor 4,7-dithien-2-yl-2,1,3-benzothiadiazole (DTBT) with a π-electron-deficient pyridine unit (DTPyT) show a smaller bandgap than their DTBT counterparts. Power conversion efficiencies of over 6 % are demonstrated in solar cell studies (see picture; PNDT, PQDT, and PBnDT represent dithiophene derivatives as weak donors). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Transmembrane Domain-derived Peptide Inhibits D1 Dopamine Receptor Function without Affecting Receptor Oligomerization (1998)

In this study, we show that a peptide based on the sequence of transmembrane domain 6 of the D1 dopamine receptor (D1DR) specifically inhibited D1DR binding and function, without affecting receptor oligomerization. It has been shown that an analogous peptide from the beta2-adrenergic receptor disrupted dimerization and adenylyl cyclase activation in the beta2-adrenergic receptor (Hebert, T. E., Moffett, S., Morello, J. P., Loisel, T. P., Bichet, D. G., Barret, C., and Bouvier, M. (1996) J. Biol. Chem. 271, 16384-16392). Treatment of D1DR with the D1DR transmembrane 6 peptide resulted in a dose-dependent, irreversible inhibition of D1DR antagonist binding, an effect not seen in D1DR with peptides based on transmembrane domains of other G protein-coupled receptors. Incubation with the D1DR transmembrane 6 peptide also resulted in a dose-dependent attenuation of both dopamine-induced [35S]guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) binding and receptor-mediated dopamine stimulation of adenylyl cyclase activity. Notably, GTPgammaS binding and cAMP production were reduced to levels below baseline, indicating blockade of ligand-independent, intrinsic receptor activity. Immunoblot analyses of the D1DR revealed the receptor existed as monomers, dimers, and higher order oligomers and that these oligomeric states were unaffected after incubation with the D1DR transmembrane 6 peptide. These findings represent the first demonstration that a peptide based on the transmembrane 6 of the D1DR may represent a novel category of noncompetitive D1DR antagonists.
Seasonal variations in vitamins A, C, riboflavin and folate intakes and status of pregnant and lactating women in a rural Gambian community: some possible implications. (1994)

In countries such as The Gambia seasonality is a major determinant of micronutrient status. However, dietary intake is not the only factor which determines micronutrient status: thus there are seasonal fluctuations in riboflavin status which, for example, may relate to changes in the balance between energy intake and output, rather than to seasonal changes in riboflavin intake.
Foot and ankle : core knowledge in orthopaedics (2007)

1. Functional Anatomy: Evolution, Motion, Comparative Primate Anatomy, Biomechanics 2. Physical Exam of the Foot and Ankle: Gastrocnemius Tightness, Peroneal, Metatarsal Hypermobility, Ankle Stability, Range of Motion, Posterior Tibial Tendon 3. Orthotics and Prosthetics 4. Flat foot: Posterior Tibial Dysfunction, Non-posterior Tibial Flatfoot, Comprehensive Approach 5. Cavus/Neuromuscular Foot: Etiologies, Muscle Balancing, Osseus Alignment 6. Diabetic foot: Vascular Disorders, Neuropathy, Ulcers, Charcot foot 7. Rheumatoid Foot: Hindfoot, Forefoot 8. Hallux Valgus: Etiology, Treatment, Complications 9. MTP Arthritis/Disorders: 1st MTP arthritis, 2nd MTP disorders Turf Toe Sesamoids 10. Lesser Toe Disorders/Metatarsalgia 11. Common Pediatric Foot Conditions (Clubfoot, Salter Fractures) 12. Entrapment Neuropathies (tarsal tunnel, anterior nerve impingment.) 13. Ankle arthritis (arthrodesis, arthroplasty, allograft, distraction, cartilage transplantation) 14. Heel pain: Plantar Fasciitis, Fat Pad Atrophy, DDX 15. Achilles Tendon: Ruptures, Tendonitis 16. Other Tendon Disorders: Peroneals, FHL, Anterior Tibia 17. Ankle Sprains: Acute, Recurrent Chronic Pain, Syndesmosis, Subtalar 18. Malleolar Fractures including Stress Fractures 19. Tibial Pilon Fractures 20. Calcaneus Fractures, including Open Reduction, Percutaneous and Late Reconstruction 21. Talus Fractures: Classification, Reduction and Fixation Techniques, Malunion, Osteochondral, process fractures 22. Navicular/midfoot injuries including Navicular Stress Fractures 23. Metatarsal/Phalanx Fracture: 5th Metatarsal Fractures, Stress Fractures 24. Tumors of the Foot/Ankle 25. Amputations 26. Foot and Ankle Athroscopy 27. Nail problems in the foot