gebhart/patrepeval huggingface dataset:
A Study on the Status of the Oral Health for Seafarers (2004)

To maintain and improve seafarers oral health, I investigated and analyzed the oral health status of seafarers'. who are safety training at Korea Institute of Maritime and Fisheries Technology located in located in Busan. The results of the investigation and analysis are as follows. Two times of brushing teeth a day occupied 51.0% the largest percentage, mixed brushing method was the highest as 39.0%, 64.2% of respondents have received teeth scaling. Two or three of times snack intake per day occupied 62.6% the largest percentage. Based on the objects' answer on oral status, the persons answered that my oral status is 'good' 25.9% 'bad' 38.3% occupied. The persons with a decayed tooth occupied 78.1% and as for the subjective symptoms of oral disease, 25.6% of respondents answered that I felt sensitivity. Intraoral discomfortable symptoms in the respect of each age, under forty age had dental decay, over forty age had sensitivity of teeth. The more has a intake snack, the more has an oral disease and oral decayed tooth. As a whole of the above results in order to control oral health of the seafarers reasonably, time and economic limiting factors must be solved in the first. In planning oral health education, practicability should be emphasized especially.
Anatomy of the human patellofemoral joint articular cartilage: Surface curvature analysis (1997)

Articular cartilage surfaces of 49 human patellae and 24 distal femora were characterized by identifying distinctive features with surface curvature analysis. Paired specimens from the same donor generally exhibited natural symmetry, so only results from nonpaired specimens were considered (39 patellae and 19 femora). In 23 of 39 patellae, proximal median and lateral transverse ridges extended to form an oblique ridge resembling a skewed lambda (lambda). Most of the unpaired patellae (37 of 39) exhibited only a single lateral transverse ridge, and most (32 of 39) had an odd facet. All but one patella exhibited a concave depression in the lateral and medial facets and a sellar area in the proximal region. All distal femoral surfaces exhibited a sellar trochlea. The concavity of the trochlea was greatest in the posterior aspect, near the intercondylar notch.
Evaluation of Parenteral Nutrition Errors in an Era of Drug Shortages (2015)

Despite the significant impact that shortages have had on the PN use system, no adverse impact on patient safety could be identified from these reported PN errors.
Noise modeling and capacity analysis for NAND flash memories (2014)

Flash memories have become a significant storage technology. However, they have various types of error mechanisms, which are drastically different from traditional communication channels. Understanding the error models is necessary for developing better coding schemes in the complex practical settings. This paper endeavors to survey the noise and disturbs in NAND flash memories, and construct channel models for them. The capacity of flash memory under these models is analyzed, particularly regarding capacity degradation with flash operations, the trade-off of sub-thresholds for soft cell-level information, and the importance of dynamic thresholds.
VA RNAs from avian and human adenoviruses: dramatic differences in length, sequence, and gene location (1986)

Human adenoviruses encode low-molecular-weight RNAs, so-called VA RNAs, which are transcribed by RNA polymerase III. These RNAs are required for an efficient translation of viral mRNAs late after infection. The genes for the VA RNAs in the genome of CELO virus were mapped and characterized. The results showed a number of surprising differences between CELO virus and human adenovirus type 2 (Ad2). Thus, the CELO virus genome encoded only one VA RNA species, in contrast to human Ad2, which encoded two distinct species. The VA RNA from CELO virus was much shorter than the Ad2 VA RNAs (90 nucleotides compared with 160 nucleotides), and there existed no detectable primary sequence homology between them. The predicted secondary structure of CELO virus VA RNA was, however, similar to that of the Ad2 VA RNAs, implying that the folding rather than the primary sequence was the important feature for biological activity. CELO VA RNA also stimulated translation in a transient expression assay, as did the Ad2 counterparts, albeit with a much lower efficiency. The location of the gene for CELO VA RNA also differed from all previously characterized serotypes, suggesting that the genome organization of avian and human adenoviruses are different. Finally, termination of CELO VA RNA transcription occurred in a TTATT sequence which is unique as a stop signal for RNA polymerase III transcription.
Pulmonary Hypertension as a Risk Factor for Death in Patients with Sickle Cell Disease (2004)

Pulmonary hypertension, diagnosed by Doppler echocardiography, is common in adults with sickle cell disease. It appears to be a complication of chronic hemolysis, is resistant to hydroxyurea therapy, and confers a high risk of death. Therapeutic trials targeting this population of patients are indicated.
Effects of Thomsen-Friedenreich antigen-specific peptide P-30 on beta-galactoside-mediated homotypic aggregation and adhesion to the endothelium of MDA-MB-435 human breast carcinoma cells. (2000)

Both the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are important if not critical during early stages of cancer metastasis. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (T antigen) and beta-galactoside binding lectins (galectins) have been implicated in tumor cell adhesion and tissue invasion. In this study, we demonstrate the involvement of T antigen in both homotypic aggregation of MDA-MB-435 human breast carcinoma cells and their adhesion to the endothelium. The T antigen-specific peptide P-30 (HGRFILPWWYAFSPS) selected from a bacteriophage display library was able to inhibit spontaneous homotypic aggregation of MDA-MB-435 cells up to 74% in a dose-dependent manner. Because T antigen has beta-galactose as a terminal sugar, the expression profile of beta-galactoside-binding lectins (galectins) in MDA-MB-435 cells was studied. Our data indicated the abundant expression of [35S]methionine/cysteine-labeled galectin-1 and galectin-3 in this cell line, which suggested possible interactions between galectins and T antigen. As revealed by laser confocal microscopy, both galectin-1 and galectin-3 also participate in the adhesion of the MDA-MB-435 cells to the endothelium. We observed the clustering of galectin-3 on endothelial cells at the sites of the contact with tumor cells, consistent with its possible interaction with T antigen on cancer cells The galectin-1 signal, however, strongly accumulated at the sites of cell-cell contacts predominantly on tumor cells. The T antigen-specific P-30 significantly (50%) inhibited this adhesion, which indicated that T antigen participates in the adhesion of MDA-MB-435 breast cancer cells to the endothelium. The ability of synthetic P-30 to inhibit both the spontaneous homotypic aggregation of MDA-MB-435 cells and their adhesion to the endothelium (>70 and 50%, respectively) suggests its potential functional significance for antiadhesive therapy of cancer metastasis.
Mirtazapine, a Noradrenergic and Specific Serotonergic Antidepressant, Attenuates Morphine Dependence and Withdrawal in Sprague-Dawley Rats (2008)

The effects of mirtazapine, a noradrenergic and specific serotonergic antidepressant, on morphine withdrawal and morphine conditioned place preference (CPP) were investigated in rats. Our results showed that some morphine withdrawal signs, including teeth chattering, grooming, chewing, and escape attendance, were attenuated by single pretreatments with 3, 10, or 30 mg/kg mirtazapine. Wet-dog shakes, rearing, and grooming were inhibited by daily pretreatment with 1, 3, or 10 mg/kg mirtazapine. The expression of morphine-induced CPP was significantly blocked by mirtazapine (10 or 30 mg/kg, i.p.), while chronic treatment with mirtazapine (1 or 10 mg/kg, i.p. once, daily, for six consecutive days) significantly attenuated the acquisition of morphine CPP. Our results demonstrated that mirtazapine attenuates morphine withdrawal and morphine-induced CPP in rats and suggest that mirtazapine may have therapeutic potential in the treatment of opiate dependence.
Virologic and serologic studies of progressive multifocal leukoencephalopathy. (1983)

The human polyomavirus JCV has been associated with diseased brain tissue from 54 cases of PML. The disease occurred in persons of all ages--the youngest being 5 years old--whose immune mechanisms were depressed for any of a variety of reasons. In six patients the disease ceased progressing and they stabilized or improved. The brains of two of these, who died months or years later, were found to be free of active PML at autopsy. Sera from 21 patients had HAI antibodies against JCV, but none had antibodies against T or the common internal antigens, and only one had IgM antibodies detectable by immunofluorescent staining. Nine CSF were devoid of JCV-related antibodies except for one which gave an HAI titer of 8. Virus has been isolated from 15 PML brains, and preliminary studies indicate that one isolate, while clearly of JCV type, is serologically distinguishable from prototype Mad 1 JCV.
The phenotypic and cytogenetic spectrum of partial trisomy 9 (1985)

A new patient with trisomy for the chromosome segment 9pter----q22 is compared to 19 previously reported cases of partial trisomy 9. Manifestations such as microcephaly, prominent nasal root, bulbous nose, and down-turned corners of the mouth are common to patients with trisomic segments extending from 9p21 to 9q13, while intra-uterine growth retardation, cleft lip/palate, skeletal anomalies, and heart defects are more common with trisomic segments extending through 9q22-9q32. A graphic method illustrates this progression in the partial trisomy 9 malformation spectrum as the triplicated chromosome region extends from bands 9p21 to 9q32. More severe and random defects are observed with complete trisomy 9 or tetrasomy 9p, suggesting an extreme excess of material greatly increases developmental variability.
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice (2003)

Objective: Atherosclerosis is an inflammatory disease in which T helper 1 (Th1) immunity has been proposed to play an important role. Nave CD41 T cells differentiate into interferon-g (IFN-g) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) 2 / 2 and IL-12. We wanted to directly test whether the Th1 pathway is proatherogenic. Methods: We bred IL-18 mice with apolipoprotein 2 / 2 2 / 2 2 / 2 E (apoE ) mice and assessed atherosclerosis in the aortic root of the offspring. Results: 24-week-old IL-18 deficient apoE mice 2 1 / 1 2 / 2 exhibited substantially reduced lesion size (93 866611 273 vs. 144 01969667 mm in IL-18 3apoE mice, P50.005). Lesion cells b in compound knockout mice displayed reduced I-A expression, implying reduced local IFN-g stimulation. These mice also had an increased proportion of a-SM-actin1 smooth muscle cells, compatible with a more stable lesion phenotype. Immunoglobulin G (IgG) subclass analysis of antibodies to malondialdehyde-modified low density lipoprotein indicated increased Th2 and reduced Th1 helper to B 2 / 2 2 / 2
Levamisole in the Adjuvant Treatment of Colon Cancer (1991)

The chemistry, pharmacology, pharmacokinetics, assay methodologies, adverse effects, and dosage of levamisole are described, and the clinical studies of levamisole therapy in patients with colorectal carcinoma are reviewed. Levamisole is a synthetic, orally active agent that has antihelmintic and immunomodulatory properties. It is capable of inducing T-cell differentiation and restoring depressed effector functions of peripheral lymphocytes and phagocytes to normal. The drug is well absorbed from the gastrointestinal tract after oral administration and is extensively metabolized by the liver. Gas chromatography and high-performance liquid chromatography are the most common methods used to measure concentrations of levamisole in biologic fluids. Levamisole combined with fluorouracil has been associated with a one-third reduction in recurrence and risk of death in patients with surgically resected Dukes stage C colon cancer; this combination is now recommended as standard therapy in these patients. Uses in patients with rectal carcinoma, Dukes stage B colon cancer, metastatic colon cancer, other malignancies, or nonmalignant disorders remain investigational. Common adverse effects include nausea, abdominal pain, vomiting, diarrhea, metallic or altered taste, flulike symptoms, mood elevation, insomnia, hyperalertness, dizziness, and headache. The most serious adverse effect associated with levamisole is granulocytopenia. The FDA-approved dosage of levamisole is 50 mg orally every eight hours for three days every two weeks. Levamisole therapy is to be initiated no earlier than 7 and no later than 30 days after surgery and is to be continued for one year. Levamisole combined with fluorouracil has been associated with a one-third reduction in recurrence and risk of death in patients with resected stage C colon cancer. Further research is needed to more clearly define the mechanism of action, optimum dose and scheduling, and clinical efficacy of levamisole in treating other malignancies.
Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor (2001)

Pigment epithelium-derived factor (PEDF), a noninhibitory member of the serpin superfamily, is the most potent inhibitor of angiogenesis in the mammalian ocular compartment. It also has neurotrophic activity, both in the retina and in the central nervous system, and is highly up-regulated in young versus senescent fibroblasts. To provide a structural basis for understanding its many biological roles, we have solved the crystal structure of glycosylated human PEDF to 2.85 A. The structure revealed the organization of possible receptor and heparin-binding sites, and showed that, unlike any other previously characterized serpin, PEDF has a striking asymmetric charge distribution that might be of functional importance. These results provide a starting point for future detailed structure/function analyses into possible mechanisms of PEDF action that could lead to development of therapeutics against uncontrolled angiogenesis.
Collagen types I, III, and V in human embryonic and fetal skin (1986)

The dermis of human skin develops embryonically from lateral plate mesoderm and is established in an adult-like pattern by the end of the first trimester of gestation. In this study the structure, biochemistry, and immunocytochemistry of collagenous matrix in embryonic and fetal dermis during the period of 5 to 26 weeks of gestation was investigated. The dermis at five weeks contains fine, individual collagen fibrils draped over the surfaces of mesenchymal cells. With increasing age, collagen matrix increases in abundance in the extracellular space. The size of fibril diameters increases, and greater numbers of fibrils associate into fiber bundles. By 15 weeks, papillary and reticular regions are recognized. Larger-diameter fibrils, larger fibers, denser accumulations of collagen, and fewer cells distinguish the deeper reticular region from the finer, more cellular papillary region located beneath the epidermis. The distribution of collagen types I, III, and V were studied at the light microscope level by immunoperoxidase staining and at the ultrastructural level by transmission (TEM) and scanning electron microscopy (SEM) with immunogold labeling. By immunoperoxidase, types I and III were found to be evenly distributed, regardless of fetal age, throughout the dermal and subdermal connective tissue with an intensification of staining at the dermal-epidermal junction (DEJ). Staining for types III and V collagen was concentrated around blood vessels. Type V collagen was also localized in basal and periderm cells of the epidermis. By immuno-SEM, types I and III were found associated with collagen fibrils, and type V was localized to dermal cell surfaces and to a more limited extent with fibrils. The results of biochemical analyses for relative amounts of types I, III, and V collagen in fetal skin extracts were consistent with immunoperoxidase data. Type I collagen was 70-75%, type III collagen was 18-21%, and type V was 6-8% of the total of these collagens at all gestational ages tested, compared to 85-90% type I, 8-11% type III, and 2-4% type V in adult skin. The enrichment of both types III and V collagen in fetal skin may reflect in part the proportion of vessel- and nerve-associated collagen versus dermal fibrillar collagen. The accumulation of dermal fibrillar collagen with increasing age would enhance the estimated proportion of type I collagen, even though the ratios of type III to I in dermal collagen fibrils may be similar at all ages.
Self-structuring antennas (2002)

This paper introduces a new class of antennas, called self-structuring antennas (SSAs). An SSA has the ability to alter its electrical shape in response to changes in its environment. This property makes an SSA suitable for use in a number of traditionally difficult antenna situations. The basic principles of the SSA are introduced, and a number of potential applications are highlighted. Details of a simple prototype antenna are provided. Computer tools capable of analyzing the SSA are described, and results of both numerical and experimental investigations of the SSA are presented.
Vector instruction set support for conditional operations (2000)

Vector instruction sets are receiving renewed interest because of their applicability to multimedia. Current multimedia instruction sets use short vectors with SIMD implementations, but long vector, pipelined implementations have a number of advantages and arc a logical next step in multimedia ISA development.Support for conditional operations (as occur in loops containing IF statements) is an important aspect of a vector ISA. Seven ISA alternatives for implementing conditional operations are systematically explored. Performance considerations are discussed through evaluation of a typical IF loop over a range of vector lengths and true conditional values. An approach using masked operations is shown to be one of the better methods, especially if its implementation is able to skip over blocks of false mask bits. Additional analyses of complex IF loops and parallel pipeline implementations support the masked operation approach. The paper concludes with a practical implementation of masked operations that skips over power-of-2-length blocks of false values. This implementation is simpler than skipping arbitrary-length blocks and provides similar performance.
Glycosylation Pathways as Drug Targets for Cancer: Glycosidase Inhibitors (2006)

The combined and ordered sequential action of glycosidases and glycosyltransferases in mammalian cell compartments leads to the addition of defined glycans to proteins and lipids. Altered glycosylation patterns, neoexpression, underexpression or overexpression of glycans are a hallmark of cancer. These changes are either found in the core or the terminal structures of the carbohydrates of glycoproteins. Affected proteins can be either cellular, cell-surface or secreted proteins, and glycosylation modifications frequently result in a modified expression, metabolism, functions, properties, stability and/or cellular localization of glycoproteins in cancer cells, resulting in part in their uncontrolled growth and aggressive behavior. Therefore glycosylation pathways, and the glycosidases and glycosyltransferases of these pathways, represent potential innovative modalities for drug development in cancer therapies which are just beginning to be explored. This review proposes to summarize the published information for glycosidases and their inhibitors in cancer.
Docking of human interleukin‐15 to its specific receptor α chain: Correlation between molecular modeling and mutagenesis experimental data (2006)

A structural model of the sushi domain of IL-15Ralpha was first obtained by homology modeling to study its interactions with IL-15 by means of molecular modeling, peptide scanning, and site-directed mutagenesis. From these experimental data, a putative interacting surface of IL-15Ralpha with a previously published IL-15 model was inferred: Leu25, Leu44, and Glu46 of IL-15 and Arg35 of IL-15Ralpha were found to be key interfacial residues and were subsequently used as filters for the construction of docking solutions. Human IL-15/IL-15Ralpha complexes were constructed in two stages, with a preliminary docking procedure, treating the two partners as rigid bodies and using these filters. In this first stage, two classes of docking solutions were characterized. From a topological point of view, each solution could be derived from the other by reverse orientation of one partner in relation to the other. In a second stage, several further energy refinements clearly favored one solution. Moreover, this unique docking solution was confirmed by molecular modeling of IL-15 mutants previously built and tested in our laboratory. Finally, this complex model, which is a useful tool to study the IL-15/IL-15Ralpha interface, was topologically compared to IL-2/IL-2Ralpha complexes (previous model in the literature and recent crystal structure).
Rise and Fall of an Anti-MUC1 Specific Antibody (2011)

Antibody phage display starting with immune libraries and followed by affinity maturation is a powerful strategy to generate high affinity human antibodies to difficult targets, in this case shown by the creation of a highly specific antibody with subnanomolar affinity to a very small epitope consisting of four amino acids. Despite these "best in class" binding parameters, the therapeutic success of this antibody was prevented by the target biology.
Trends in Modern Mineralogy in Japan (1983)

Trends in modern mineralogy have been reviewed, mainly based on the group efforts of the mineragloical society. Since early 1970 s, a list of scientific research grants of the Ministry of Education directed to specific large projects have shown that mineralogists have been involved in many branc hes of sciences including, crystal growth, information retrieval, material sciences, microstructures, planetary sciences and ceramics. These grants have provided mineralogists with large expensive equipments such as electron microprobe, single crystal diff ractometera analytical transmission electron microscope. However, lack of man power to operate these machines prevented further developments of the fields. Availability of new planetary samples such as lunar samples and Antarctic meteorites, and synthetic minerals opened up new fields of investigation in the past decade. Recommendations to the Government on the promotion of meteorite sciences and development and evolution of lithosphere project (DELP) etc indicate future activities in the mineralogical fields.