gebhart/patrepeval huggingface dataset:
The Effects of dietary n−3/n−6 ratio on brain development in the mouse: a dose response study with long‐chain n−3 fatty acids (1992)

This study examines the effects of the ratio of n-3/n-6 fatty acids (FA) on brain development in mice when long-chain n-3 FA are supplied in the diet. From conception until 12 days after birth, B6D2F1 mice were fed liquid diets, each providing 10% of energy from olive oil, and a further 10% from different combinations of free FA concentrates derived from safflower oil (18:2n-6), and fish oil (20:5n-3 and 22:6n-3). The range of dietary n-3/n-6 ratios was 0, 0.25, 0.5, 1.0, 2.0 and 4.0, with an n-6 content of greater than 1.5% of energy in all diets, and similar levels of total polyunsaturated fatty acids (PUFA). In an additional group of ratio 0.5, 18:2n-6 was partially replaced by its delta 6 desaturation product, 18:3n-6. Biochemical analyses were conducted on 12-day-old pup brains, as well as on samples of maternal milk. No obvious effects on overall pup growth and development were observed, apart from a smaller litter size at ratio 1. Co-variance analysis indicated that increasing the n-3/n-6 ratio was associated with slightly smaller brains, relative to body weight. We found that 18:2n-6 and 20:5n-3 were the predominant n-6 and n-3 FA in the milk; in the brain these were 20:4n-6 and 22:6n-3, respectively. Increasing dietary n-3/n-6 ratios generally resulted in an increase in n-3 FA, with a corresponding decrease in n-6 FA.(ABSTRACT TRUNCATED AT 250 WORDS)
Introduction (2013)

At the start of this text it is useful to understand where this book has come from and why it is being written now. To a large extent it has come out of our personal experiences, both of spiritual abuse (SA) and of counselling individuals who have experienced this. SA was a term that we had never encountered until February 2001 when Lisa first experienced it. At no point had the notion of this form of abuse entered our consciousness, despite going to church from childhood. It was never spoken about and we were unaware of its existence. This lack of awareness placed me (Lisa) in a very difficult position when I personally experienced SA and me (Kathy) in a very difficult position when counselling people who had experienced SA.
Thiol−Disulfide Exchange in an Immunoglobulin-like Fold:  Structure of the N-Terminal Domain of DsbD, (2002)

Escherichia coli DsbD transports electrons across the plasma membrane, a pathway that leads to the reduction of protein disulfide bonds. Three secreted thioredoxin-like factors, DsbC, DsbE, and DsbG, reduce protein disulfide bonds whereby an active site C-X-X-C motif is oxidized to generate a disulfide bond. DsbD catalyzes the reduction of the disulfide of DsbC, DsbE, and DsbG but not of the thioredoxin-like oxidant DsbA. The reduction of DsbC, DsbE, and DsbG occurs by transport of electrons from cytoplasmic thioredoxin to the C-terminal thioredoxin-like domain of DsbD (DsbD(C)). The N-terminal domain of DsbD, DsbD(N), acts as a versatile adaptor in electron transport and is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD(C). Isolated DsbD(N) is functional in electron transport in vitro. Crystallized DsbD(N) assumes an immunoglobulin-like fold that encompasses two active site cysteines, C103 and C109, forming a disulfide bond between beta-strands. The disulfide of DsbD(N) is shielded from the environment and capped by a phenylalanine (F70). A model is discussed whereby the immunoglobulin fold of DsbD(N) may provide for the discriminating interaction with thioredoxin-like factors, thereby triggering movement of the phenylalanine cap followed by disulfide rearrangement.
SURGICAL THERAPY FOR PERSISTENT HYPERTENSION AFTER RENAL TRANSPLANTATION (1981)

The presence of the original diseased native kidneys in renal allograft recipients is associated with an increased prevalence of persisting post-transplant hypertension. In 9 of 10 such transplant patients bilateral nephrectomy of these native kidneys, performed at least 1 year after successful transplantation of a renal allograft, resulted in improved blood pressure control. Although these 10 patients had higher peripheral plasma renin activity (PRA) than normotensive patients (5.9 +/- 1.3 ng/ml/hr versus 1.5 +/- 0.3 mg/ml/hr), selective renal vein renin measurements did not consistently demonstrate higher renin concentrations from the native kidneys. Removal of the original kidneys was beneficial even in some patients who had stenosis of the allograft artery demonstrated by arteriography.
Synthesis of TiO2 Nanocrystals by Nonhydrolytic Solution-Based Reactions (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSynthesis of TiO2 Nanocrystals by Nonhydrolytic Solution-Based ReactionsTimothy J. Trentler, Tiffany E. Denler, Jane F. Bertone, Aarti Agrawal, and Vicki L. ColvinView Author Information Department of Chemistry Center for Nanoscale Science and Technology Rice University, Houston, Texas 77005 Cite this: J. Am. Chem. Soc. 1999, 121, 7, 1613–1614Publication Date (Web):February 9, 1999Publication History Received21 September 1998Published online9 February 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/ja983361bhttps://doi.org/10.1021/ja983361brapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views4891Altmetric-Citations352LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical reactions,Halogens,Inorganic compounds,Nanoparticles,Oxides Get e-Alerts
Photodynamic Action of Rose Bengal Silica Nanoparticle Complex on Breast and Oral Cancer Cell Lines (2011)

Rose Bengal, an anionic photosensitizer was conjugated to organically modified silica nanoparticles having 3-amino propyl groups by electrostatic or covalent interaction. The drug-nanoparticle complexes were characterized by FTIR, light scattering and zeta potential measurements. Significant changes were observed in the spectroscopic properties of the drug when it is conjugated with nanoparticles. The toxicity of the free drug and drug-nanoparticle complex was studied against oral (4451) and breast (MCF-7) cancer cell lines. Both complexes with nanoparticles were more phototoxic than free Rose Bengal, with the covalent complex being the more effective. Studies carried out on cellular uptake, photostability and singlet oxygen generation suggest that enhanced phototoxicity is primarily due to the enhanced uptake of the drug-nanoparticle complex.
Study on Open Tubular Capillary Affinity Liquid Chromatography (2000)

A novel mode of affinity chromatography (AC) based on an open tubular capillary column (OTAC) is demonstrated. The OTAC column is prepared by immobilizing Cibacron blue F3GA onto the inner surface of a 50-microm-i.d. capillary column. The AC experiment is performed on a capillary electrophoresis instrument by using its pressure system as the driving force. Bovine serum albumin and lysozyme (Lys) are successfully separated with stepwise gradient elution. The relative standard deviation (RSD) for the elution time of the retained Lys is 0.08%, and good repeatability of its peak area and peak height with an RSD value lower than 2.12% for 10 consecutive runs is observed. The loading capacity and detection limit for the retained Lys are approximately 36 ng and 8.6 ng, respectively. It is also found that the amount of protein adsorbed is unaffected by the flow rate of the loading buffer, and OTAC can be used for the fast determination of biopolymers. Some of the advantages of OTAC over conventional modes of open tubular capillary liquid chromatography are that the detection sensitivity and loading capacity of a sample can be greatly improved, because the relatively large inner diameter of the capillary can be adopted and the whole capillary column can be used to adsorb the solute in OTAC.
Open air deposition of SiO2 film from a cold plasma torch of tetramethoxysilane-H2-Ar system (1994)

A rf plasma beam was generated in the stream of atmospheric pressure argon to be exhausted from a cylindrical nozzle into air. The temperature measurements indicate a nonequilibrium low temperature nature of this plasma. By using this cold plasma torch, films were deposited on the substrates placed in air at growth rates higher than 100 Å/s by feeding tetramethoxysilane into the plasma. Fourier transform infrared spectroscopy and x-ray photoelectron spectroscopy revealed that the films were essentially SiO2 and their structures and properties could be improved by admixing hydrogen in the plasma. The SiO2 films deposited at a rate of 120 Å/s from Si(OCH3)4-H2-Ar plasma had surfaces as smooth and hard as Corning 7059 glass.
Mechanism of action of sacral nerve stimulation using a transdermal amplitude-modulated signal in a spinal cord injury rodent model (2012)

: TAMS caused a reduction in NDO by inhibiting C-fibre activity.
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats. (2006)

The dual endothelin receptor antagonist, bosentan, and the phosphodiesterase inhibitor, sildenafil, are efficacious in experimental and clinical pulmonary hypertension (PHT). The effects of bosentan, sildenafil, and their combination were evaluated in rats with monocrotaline (MCT)-induced PHT. A first group consisted of control rats with no MCT injection. Four other groups of rats received MCT subcutaneously and were assigned to receive no treatment, 300 mg/kg/day bosentan as food admix, 100 mg/kg/day sildenafil in drinking water, or their combination for 4 weeks. The doses of bosentan and sildenafil were the maximally effective doses based on a dose-range-finding study. Mortality was 0%, 53%, 11%, 11%, and 0%, respectively, in the five different groups. Bosentan and sildenafil significantly attenuated the increase in mean pulmonary arterial pressure, and the combination had an additional effect. Similarly, bosentan, sildenafil, and, to a greater extent, their combination significantly reduced right ventricular (RV) hypertrophy. Bosentan, but not sildenafil, decreased norepinephrine and BNP plasma concentrations, reduced kidney weight, and normalized systemic hemodynamics. In conclusion, bosentan and sildenafil are efficacious in rats with chronic PHT, and their combination shows an additional effect for decreasing pulmonary arterial pressure, reducing plasma catecholamines, maintaining body weight, and reducing mortality.
The Anticoagulants of Choice for Platelet Transfusions (1966)

A study was made of the recovery of Cr 51 ‐labeled platelets transfused to normal recipients using various anticoagulant solutions. With ethylenediamine‐tetra‐acetate (EDTA) recoveries averaged 27 per cent (range 15% to 35%). With ACD (N.I.H. formula A) recoveries averaged 37 per cent (range 34% to 41%). With a citrate solution containing additional acid so as to reduce the p H of platelet‐rich plasma to 6.5 before concentration of cells, recoveries averaged 62 per cent (range 37% to 81%). Platelet clumping, usually a problem when platelets are concentrated in citrate, was prevented at p H 6.5. It is suggested that a citrate solution containing sufficient acid to buffer platelet‐rich plasma at p H 6.5 will increase the effectiveness of platelet concentrates.
Pre-Clinical Evaluation of a Novel Nanoemulsion-Based Hepatitis B Mucosal Vaccine (2008)

Our results suggest that needle-free nasal immunization with HBsAg-NE could be a safe and effective hepatitis B vaccine, or provide an alternative booster administration for the parenteral hepatitis B vaccines. This vaccine induces a Th1 associated cellular immunity and also may provide therapeutic benefit to patients with chronic hepatitis B infection who lack cellular immune responses to adequately control viral replication. Long-term stability of this vaccine formulation at elevated temperatures suggests a direct advantage in the field, since potential excursions from cold chain maintenance could be tolerated without a loss in therapeutic efficacy.
Ionic Liquid (Molten Salt) Phase Organometallic Catalysis (2002)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIonic Liquid (Molten Salt) Phase Organometallic CatalysisJairton Dupont, Roberto F. de Souza, and Paulo A. Z. SuarezView Author Information Laboratory of Molecular Catalysis, Institute of Chemistry, UFRGS, Av. Bento Gonçalves, 9500 Porto Alegre 91501-970, RS, Brazil Cite this: Chem. Rev. 2002, 102, 10, 3667–3692Publication Date (Web):August 21, 2002Publication History Received30 January 2002Published online21 August 2002Published inissue 1 October 2002https://pubs.acs.org/doi/10.1021/cr010338rhttps://doi.org/10.1021/cr010338rresearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views18909Altmetric-Citations3445LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Catalysts,Precursors,Salts,Solvents Get e-Alerts
In Situ Fabrication of Halide Perovskite Nanocrystal‐Embedded Polymer Composite Films with Enhanced Photoluminescence for Display Backlights (2016)

A simple and versatile in situ fabrication of MAPbX<sub>3</sub> nanocrystal-embedded polymer composite films is developed by controlling the crystallization process from precursor solutions. The composite films exhibit enhanced photoluminescence properties, improved stability, and excellent piezoelectric and mechanical properties. Applications of these composite films as color converters in liquid-crystal-display backlights are demonstrated, showing bright potential in display technology.
Using voxel-dependent importance factors for interactive DVH-based dose optimization (2002)

Intensity modulated radiation therapy (IMRT) inverse planning is usually performed by pre-selecting parameters such as beam modality, beam configuration and importance factors and then optimizing the fluence profiles or beamlet weights. In reality, the IMRT dose optimization problem may be ill-conditioned and there may not be a physical solution to account for the chosen parameters and constraints. Planner intervention is often required to conduct a multiple trial-and-error process where several parameters are sequentially varied until an acceptable compromise is achieved. The resulting solution reflects a balance between the conflicting requirements of the target and the sensitive structures. A major problem of the conventional inverse planning formalism is that there exists no effective mechanism for a planner to fine-tune the dose distribution on a local level or to differentially modify the dose-volume histograms (DVHs) of the involved structures. In this paper we introduce a new inverse planning scheme with voxel-dependent importance factors and demonstrate that it provides us with an effective link between the system parameters and the dosimetric behaviour at a local level. The planning proceeds in two steps. After a conventional trial-and-error inverse planning procedure is completed, we identify the dose interval at which the fractional volume on the DVH curve needs to be changed. The voxels that receive dose in the selected range are then located and their voxel-dependent importance factors are adjusted accordingly. The fine-tuning of the DVHs is iterative in nature and, using widely available computer graphic software tools, the process can be made graphically interactive. The new IMRT planning scheme is applied to two test cases and the results indicate that our control over the differential shapes of the DVHs of the involved structures is,greatly enhanced. Thus the technique may have significant practical implications in facilitating the IMRT treatment planning process.
REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHT (1982)

Melatonin was estimated by RIA in samples taken at 24.00 h and 08.00 h from twenty-one male chronic schizophrenics and twelve age--sex matched controls and subsequently in more frequent nocturnal samples from nine of the chronic schizophrenics. The 24.00 h melatonin level and the 24.00/08.00 h melatonin ratio were significantly reduced in the chronic schizophrenic patients. Similar results, with no evidence of subsidiary peaks of melatonin secretion, were obtained in those patients who were retested. No relationships between melatonin secretion and age or anterior pituitary hormone secretion were demonstrated, but an effect of body weight was noted which accounted, in part, for the difference between schizophrenics and controls. These results suggest that the low levels of melatonin noted in studies on depressed patients may not be specific and that body weight must be controlled in subsequent studies of melatonin secretion in patients with psychiatric disease.
Cosmic Order: An Intelligent Face to Evolution (2012)

During Darwin’s time the biblical Genesis account was considered by many scholars to be allegorical and various ideas about the transmutation of species were already in circulation. Influenced by findings on the Beagle trip that embarked in 1831 and by communications with others, including A.R. Wallace who had a nearly identical theory, Darwin eventually published his famous book On the Origin of Species. His idea was that small heritable changes over a long period of time can endow a survival advantage in a process of natural selection that can lead to new species. However, the process was regarded as random without plan or purpose. It met with opposition and various amendments until it became generally accepted scientific dogma in the 1930’s and 1940’s. The views of an ardent proponent of the Darwinian paradigm will be briefly assessed. This will be followed by discussions of some compelling evidence for hierarchical organization as a pervasive feature of the cosmic order, from the physical evolution of the cosmos to biological evolution on the planet Earth.
Globally consistent depth labeling of 4D light fields (2012)

We present a novel paradigm to deal with depth reconstruction from 4D light fields in a variational framework. Taking into account the special structure of light field data, we reformulate the problem of stereo matching to a constrained labeling problem on epipolar plane images, which can be thought of as vertical and horizontal 2D cuts through the field. This alternative formulation allows to estimate accurate depth values even for specular surfaces, while simultaneously taking into account global visibility constraints in order to obtain consistent depth maps for all views. The resulting optimization problems are solved with state-of-the-art convex relaxation techniques. We test our algorithm on a number of synthetic and real-world examples captured with a light field gantry and a plenoptic camera, and compare to ground truth where available. All data sets as well as source code are provided online for additional evaluation.
Detection of Human Papillomavirus 16 Transcription in Human Prostate Tissue (1993)

Previously we demonstrated human papillomavirus type 16 DNA in a high proportion of benign hyperplastic (BPH) and cancerous (CaP) prostate specimens using the polymerase chain reaction (PCR). While these data designate the prostate as a possible reservoir for sexual transmission of HPV, an etiological role for the virus in prostatic neoplasia is uncertain. Since transcription of the E6/E7 genes of HPV 16 is essential for both viral replication and cellular transformation, we sought to assess the transcriptional activity of HPV 16 found in prostate tissues. The E6/E7 viral gene transcripts were identified in 5 of 10 BPH specimens and 3 of 7 CaP specimens known to contain HPV 16 DNA. Expression of the HPV viral genes is not associated preferentially with either BPH or CaP, nor is transcription observed in all samples which contain the viral genome. These findings suggest that the prostate may act as a site for HPV replication, but that HPV is unlikely to be involved in the transformation of prostatic cells.
Translocation of microparticles in a fluid-flow by adjusting the operating frequency of ultrasonic standing wave (USW) (2011)

Recently, many studies have been reported on the non-contact manipulation of microparticles in a fluid-flow using ultrasound since ultrasonic standing wave enables particles to align to its pressure nodal or anti-nodal plane depending on their density and compressibility due to the acoustic radiation force. This phenomenon can be applied usefully to noncontact and rapid manipulation such as trapping and translocation of organic or inorganic microparticles like cells and ceramic powder in many technological fields. The objective of this work is to find an efficient way to translocate microparitcles to one side of a flow channel in the aim of several applications like filtration & separation of particles & cells etc. A modularized microchannel comprising steel and acrylic with a width of 1.5 mm was manufactured for this purpose. An ultrasound transducer installed at one side of the microchannel module generates ultrasonic standing wave field inside the channel. Ultrasound within the frequency range of 1.81 MHz ∼ 3.14 MHz was applied to concentrate particles at the pressure nodal lines. The aligned particles at pressure nodal lines can be moved in a certain degree as varying the operating frequency of the ultrasound since the location of the pressure nodes depends on the frequency. The total range of the particle movement by changing only frequency is somewhat limited, but it is possible to shift all particles nearly to the channel wall when using periodical increasing sweep as an actuation signal. The experimental results confirm that the sweeping of the operational frequency can be one of efficient methods to translocate microparticles in fluid-flow using ultrasound. This method can be successfully utilized in the field of filtration and separation techniques as well.
Effect of 35°C Hypothermia on Intracranial Pressure and Clinical Outcome in Patients With Severe Traumatic Brain Injury (2009)

Cooling patients to 35 degrees C is safe and the ICP reduction effects of 35 degrees C hypothermia are similar to those of 33 degrees C hypothermia.