gebhart/patrepeval huggingface dataset:
The professional and personal value of networking (1999)

Abstract Teacher networking is a critical (actor in the implementation of effective methods and strategies in the teaching of reading. It is particularly important for those students who are experiencing difficulties not only in the key academic areas but also for those with social‐emotional challenges. This article demonstrates the importance that different networks play for a Special Needs teacher whose school is located in a lower socio‐economic area. As primary teachers we are confronted daily with the need to learn more about our students, the people they are, their Interests, what they know and what they need to learn next We are then challenged to meet their learning needs with quality teaching and learning experiences which, over time, not only empower them to value learning and themselves as learners but encourage them to grow in the ability to take responsibility for their own learning. This is an enormous responsibility for teachers as individuals. Yet, it has been stated that, “Teaching is one of the loneliest professions” (McCann & Radford, 1996, p. 25). Networks can change this, as they offer teachers many opportunities to articulate concerns, clarify meanings and learn more about learning from each other, thus alleviating some of this loneliness. I believe that participation in networks and networking is the most powerful form of Professional Development I can engage in as a primary teacher. I am attracted to network Meetings because they bring together groups of people working with students who have similar learning needs. Networks offer me the opportunity to bring practice and theory together in order to enrich my work in the best interests of student learning. They also help me to challenge the limits of my own learning. My commitment to the value of networks and networking has developed to meet the demands of my roles as Integration/ Special Assistance Teacher and has been strengthened as a result of my training and ongoing continuing contact as a Reading Recovery Teacher.
High-frequency switching in Candida albicans (1992)

Most strains of Candida albicans are capable of switching frequently and reversibly between a number of phenotypes distinguishable by colony morphology. A number of different switching systems have been defined according to the limited set of phenotypes in each switching repertoire, and each strain appears to possess a single system. Switching can affect many aspects of cellular physiology and morphology and appears to be a second level of phenotypic variability superimposed upon the bud-hypha transition. The most dramatic switching system so far identified is the "white-opaque transition." This system dramatizes the extraordinary effects switching can have on the budding cell phenotype, including the synthesis of opaque-specific antigens, the expression of white-specific and opaque-specific genes, and the genesis of unique cell wall structures. Switching has been demonstrated to occur at sites of infection and between episodes of recurrent vaginitis, and it may function to generate variability in commensal and infecting populations for adaptive reasons. Although the molecular mechanisms involved in the switch event are not understood, recent approaches to its elucidation are discussed and an epigenetic mechanism is proposed.
The low activity of acetyl‐CoA car☐ylase in basal and glucagon‐stimulated hepatocytes is due to phosphorylation by the AMP‐activated protein kinase and not cyclic AMP‐dependent protein kinase (1988)

Acetyl-CoA carboxylase purified from isolated hepatocytes is activated dramatically by protein phosphatase treatment, concomitant with a reduction of the phosphate content from 3.7 to 1.1 mol/subunit. Glucagon treatment of the cells produces a further inactivation of the enzyme that is totally reversed by phosphatase treatment, and is associated with an increase in phosphate content of 0.8 mol/subunit, distributed in two peptides which contain the sites phosphorylated in vitro by the cyclic AMP-dependent and AMP-activated protein kinases. Sequencing of these peptides shows that the low activity of acetyl-CoA carboxylase is due to phosphorylation by the AMP-activated protein kinase, and not cyclic AMP-dependent protein kinase, even after glucagon treatment.
CXXXI.—The action of nitrous acid on the arylsulphonylmetadiamines (1906)

G. T. Morgan and F. M. G. Micklethwait, J. Chem. Soc., Trans., 1906, 89, 1289 DOI: 10.1039/CT9068901289
Glycopeptide Derived from Hen Egg Ovomucin Has the Ability To Bind EnterohemorrhagicEscherichia coliO157:H7 (2004)

Ovomucin glycopeptide (OGP) was prepared by size exclusion chromatography after Pronase digestion of hen egg ovomucin, and the binding of OGP to foodborne pathogens (Bacillus cereus,Clostridium perfringens, Escherichia coli O157:H7, Listeria monocytogenes, Salmonella enteritidis, Salmonella typhimurium, and Staphylococcus aureus) was investigaed. Binding assays with biotinylated bacteria as probes in microtiter plates showed that OGP bound to only E. coli O157:H7 among these foodborne pathogens. Periodate treatment markedly reduced the binding ability, indicating that E. coli O157:H7 bound to carbohydrate moieties of OGP. Lectin blot analysis with Maackia amurensis (MAA) and Sambucus nigra (SNA), which are specific for oligosaccharides containing sialic acid, revealed their binding sites in OGP were similar to the E. coli O157:H7 binding sites that were probed with biotinylated E. coli O157:H7 after Western blotting of OGP. Sialydase treatment of OGP abolished its ability to bind E. coli O157:H7, demonstrating that sialic acid played an important role in the binding. These results suggest that OGP has E. coli O157:H7-specific binding sites that consist of sialic acid. On the basis of these properties, OGP has the potential to be an ingredient with a protective effect against E. coli O157:H7 infection and to be a novel probe for the detection of E. coli O157:H7 in the food hygiene field.
High quality lead zirconate titanate films grown by organometallic chemical vapour deposition (1993)

Abstract Organometallic chemical vapour deposition is a suitable technique for the deposition of thin films of oxidic compounds such as lead zirconate titanate, PbZrxTi1−xO3. Above a deposition temperature of about 600°C stoichiometric PbZrxTi1−xO3 films can be grown on platinized silicon wafers within a large process window, independent of the precursor partial pressures and the deposition temperature. This is the result of a self-regulating mechanism. The PbZrxTi1−xO3 films have excellent ferroelectric properties exhibiting high values, up to 60μC/cm2, for the remanent polarisation. The value of the coercive field strength varies between 50 and 180 kV/cm, dependent on the composition. Layers with comparable properties can also be grown at lower temperatures, down to 500°C. In this case careful control of the gas-phase composition is required to obtain films with the correct stoichiometry.
Audio-visual synthesis of talking faces from speech production correlates (1999)

This paper presents an Enhanced analysis-by-synthesis (AbS) Waveform Interpolative (EWI) speech coder at 4 kbps. The system incorporates novel features such as: AbS quantization of the slowly evolving waveform (SEW), AbS vector quantization (VQ) of the dispersion phase, a special pitch search for transitions, and switched-predictive analysis-by-synthesis gain VQ. Subjective quality tests indicate that it exceeds MPEG-4 at 4 kbps and of G.723.1 at 5.3 kbps, and it is slightly better than G.723.1 at 6.3 kbps.
Detection of Single Ion Channel Activity on a Chip Using Tethered Bilayer Membranes (2007)

Membrane-bound ion channels are promising biological receptors since they allow for the stochastic detection of analytes at high sensitivity. For stochastic sensing, it is necessary to measure the ion currents associated with single ion channel opening and closing events. However, this calls for stability, high reproducibility, and long lifetimes. A critical issue to overcome is the low stability of the ion channel environment, that is, the bilayer membrane. A promising technique to surmount this is to connect the lower part of the membrane to a surface forming a tethered bilayer membrane. By reconstituting the synthetic ion channel, gramicidin A, into a tethered bilayer as part of a microchip design, we have been able to record the activity of single ion channels. The observed activity was compared with that obtained by a conventional electrophysiology method, tip dipping, to confirm its authenticity. These findings allow for the construction of stable biosensors based on ion channels and provide a novel technique for the characterization of ion channel activity.
The interaction between β-catenin, GSK3β and APC after motogen induced cell-cell dissociation, and their involvement in signal transduction pathways in prostate cancer (2001)

The effect of HGF/SF was examined on the interactions between APC, GSK3beta and beta-catenin in prostate cancer cells LNCapFGC (E-cadherin positive) and PC-3 (E-cadherin negative). Using immunoprecipitation, APC was found to be co-precipitated with either GSK3beta or beta-catenin in both cell lines. Stimulation with HGF/SF showed no change in the co-precipitation status of these protein molecules. In contrast, co-precipitation between GSK3beta and beta-catenin was only observed in LNCapFGC cells, and increased upon continued exposure to the motogen HGF/SF. Furthermore, using immunofluorescence, stimulation with HGF/SF was found to increase the level of co-localised cytoplasmic staining between beta-catenin and GSK3beta, in prostate cancer cells. RT-PCR revealed that there were no mutations within the binding regions between beta-catenin and GSK3beta. It is concluded, that uncomplexed cytoplasmic pools of beta-catenin associate more readily with the Axin complex in the absence of E-cadherin. Whereas, in the presence of E-cadherin, beta-catenin is stabilised by forming tight cell-cell contacts which may influence the invasive potential of cancer cells.
A 64 kbit/s Integrated Visual Communication System--New Communication Medium for the ISDN (1986)

Seeing-while-talking has been a dream of mankind for over a 100 years since the invention of telephone. In the past, various trials were performed in spite of the difficulty in installing the network for the actual service. However, with the progress of ISDN and the advancement of digital signal processing technology, the environment has been changing rapidly. In this paper, an integrated visual communication system is described for the enhanced communication service at 64 kbits/s, the fundamental bit rate of ISDN. The roles of state-of-theart compression of the audio and video signals are discussed and an integrated transmission method based on the priority of the information content is proposed.
EFFECT OF INDOLE-3-ACETIC ACID, KINETIN, AND ETHYLENEDIAMINETETRAACETIC ACID ON PLANT GROWTH AND UPTAKE AND TRANSLOCATION OF LEAD, MICRONUTRIENTS, AND MACRONUTRIENTS IN ALFALFA PLANTS (2008)

Alfalfa plants germinated and grown for 15 d in soil containing 80 mg Pb kg<sup>-1</sup> were treated with ethylenediaminetetraacetic acid (EDTA) at 0.8 mM and indole-3-acetic acid-kinetin (IAA-KN) at 100 μM. Fifteen days after the treatment application, the concentration of lead (Pb), macronutrients, and micronutrients was determined using inductively coupled plasma/optical emission spectroscopy. The chlorophyll content and plant growth were also measured. Roots of plants exposed to Pb alone, Pb-EDTA, and Pb-EDTA-IAA-KN had 160, 140, and 150 mg Pb kg<sup>-1</sup> DW, respectively. Pb was not detected in the stems of plants exposed to Pb alone; however, stems of plants treated with EDTA and EDTA-IAA-KN had 78 and 142 mg Pb kg<sup>-1</sup> DW, respectively. While the Pb concentration in leaves of plants treated with EDTA and EDTA-IAA-KN was 92 and 127 mg kg<sup>-1</sup> DW, respectively. In addition, EDTA and EDTA-IAA-KN significantly increased the translocation of zinc and manganese to leaves. The x-ray absorption spectroscopic studies demonstrated that Pb(II) was transported from roots to leaves without a change in the oxidation state.
Studies of a high molecular weight human melanoma-associated antigen. (1983)

Hybridomas were generated by fusing SP2/0 mouse myeloma cells with spleen cells from mice that had been immunized with cultured human melanoma cells. One of the hybridomas secreted a monoclonal IgG1 antibody, 48.7, which binds to a cell surface antigen of cells from human melanomas and compound nevi. The presence of the target antigen in vivo was demonstrated immunohistologically by staining frozen sections of primary and metastatic melanoma by the peroxidase anti-peroxidase technique. Weak staining of some blood vessel cells was also seen, but other normal cells, including skin melanocytes, were unstained, as were cells from other tumor types. Antibody 48.7 immunoprecipitated polypeptides with apparent m.w. on sodium dodecyl sulfate-polyacrylamide gel electrophoresis of 250,000 and greater than 400,000.
Skin Sensory Afterglows (1968)

Brief stimulation of the upper lip with the tip of a nylon thread frequently produces an " afterglow" sensation that may persist as long as several minutes after cessation of stimulation. The duration of afterglow is increased by strong suggestion, and decreased by vibration of the skin prior to stimulation. The afterglow may be followed by a period of acute "awareness" of the area, distincty different from the stimulus and afterglow sensations. The afterglows produced by a warm stimulator applied to the back often well up into a painful sting.
Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3. (1993)

The steroid hormone 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) generates biological responses via both genomic and nongenomic mechanisms. This article reports the biological profile of four A-ring diastereomers of this secosteroid (results are expressed as percentage of the response of 1 alpha,25-(OH)2D3. The activity of the compounds, 1 alpha,25-(OH)2D3, 1 alpha,25-(OH)2-3-epivitamin D3, 1 beta,25-(OH)2D3, 1 beta,25-(OH)2-3-epivitamin D3, for in vivo intestinal Ca2+ absorption and bone Ca2+ mobilization and in vitro binding to the nuclear receptor (genomic responses) was, respectively, 100, 2.8, < 0.1, and < 0.1% (intestinal Ca2+ absorption); 100, 1.5, < 0.1, and < 0.1% (bone Ca2+ mobilization); 100, 24, 0.2, and 0.8% (receptor binding). In the in vivo nongenomic transcaltachia assay the results were 100, 80, 0, and 20-30%, and in ROS 17/2.8 cells (45Ca2+ uptake through voltage-gated Ca2+ channels) 1 alpha,25-(OH)2D3 had 100% activity and 1 beta,25-(OH)2D3 (the only diastereomer evaluated) had no agonist activity. Keratinocyte proliferation was inhibited in the order 1 alpha,25-(OH)2D3 > 1 alpha,25-(OH)2-3-epivitamin D3 > 1 beta,25-(OH)2D3 > 1 beta,25-(OH)2-3-epivitamin D3. 1 beta,25-(OH)2D3 was a potent antagonist of 1 alpha,25-(OH)2D3-mediated transcaltachia and 45Ca2+ uptake in ROS 17/2.8 cells but was unable to block the genomic 1 alpha,25-(OH)2D3 induction of chick calbindin-D28k (in vivo), induction of MG-63 cell osteocalcin, and HL-60 cell differentiation. These results suggest that analogs of 1 alpha,25-(OH)2D3 may be synthesized which are selective agonists or antagonists of genomic or nongenomic responses in the vitamin D endocrine system.
An IgG-Fc Receptor Induced in Cytomegalovirus-Infected Human Fibroblasts (1976)

Cytomegalovirus- (CMV) infected cultured human fibroblasts incubated with normal human serum were shown to react with IgG by direct and indirect fluorescent antibody tests. The binding of IgG to infected cells was unrelated to the presence of anti-CMV complement fixing (CF) antibodies and was not observed with uninfected cells. The reaction was first observed 36 hours after infection as diffuse cytoplasmic staining which by 72 hr became localized into a dense perinuclear structure. The cytoplasmic fluorescence was not detected with anti-IgA or anti-IgM fluorescent conjugates. The reaction was seen with purified IgG and Fc fragments but was only minimally detectable with Fab fragments. It occurred in fibroblasts infected with three standard laboratory strains of CMV and seven recent CMV isolates from patients and was observed in six separate lots of human foreskin fibroblast cultures as well as in WI-38 cells. We conclude that CMV infection induces the formation of a IgG receptor in human fibroblasts.
Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo. (2002)

Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is found in cerebral neurons, and its expression is increased after hypoxic or ischemic injury, which also stimulates neurogenesis. To investigate the possible role of HB-EGF in hypoxic-ischemic induction of neurogenesis, we measured its expression, effects, and target receptors in embryonic murine cerebral cortical cultures and in adult rat brain. Hypoxia increased HB-EGF expression by approximately 50% in cortical cultures, where expression was associated with mature and immature neurons. HB-EGF (5-100 ng/ml) stimulated by approximately 80% the incorporation of bromodeoxyuridine (BrdU) into cultured cells that expressed the HB-EGF receptors epidermal growth factor receptor (EGFR)/avian erythroblastic leukemia viral oncogene homolog 1 (ErbB1) and N-arginine dibasic convertase (NRDc). Intracerebroventricular administration of HB-EGF in adult rats increased BrdU labeling in the subventricular zone and in the subgranular zone of dentate gyrus, where EGFR/ErbB1 and NRDc were also expressed and where ischemia-induced neurogenesis is observed. We conclude that HB-EGF stimulates neurogenesis in proliferative zones of the adult brain that are also affected in ischemia and that it does so by interacting with EGFR/ErbB1 and possibly NRDc. Therefore, HB-EGF may help to trigger proliferation of neuronal precursors in brain after hypoxic or ischemic injury.
Role of Bone Substitutes (1996)

Approximately 500 million years ago, the Paleozoic era heralded an evolutionary marvel: the skeleton. Unique to this evolutionary development was the capacity for regeneration: the physiologic renewal of embryologically derived tissue. Many of the cellular and molecular components for bone regeneration have been identified (bone morphogenetic proteins), and their therapeutic manipulation will become common clinical practice. Moreover, synthetic materials produced in the laboratory and novel bone derivatives will be used to exploit the skeleton's capacity to regenerate and repair. The concept of repair may be viewed as the restoration of form and function to deficient osseous tissue. Materials that provoke repair can be categorized broadly as bone substitutes. In this review, bone substitutes are grouped into 2 categories, polymers and ceramics, and each is subclassified as biodegradable or nonbiodegradable. Examples of these materials are provided as well as some of their liabilities and virtues.
A Randomized, Double-blind, Placebo-Controlled Trial of Psychostimulants for the Treatment of Fatigue in Ambulatory Patients With Human Immunodeficiency Virus Disease (2001)

Many patients with HIV- and acquired immunodeficiency syndrome-unrelated fatigue respond favorably to treatment with methylphenidate or pemoline. Both psychostimulants appear to be equally effective and significantly superior to placebo in decreasing fatigue severity with minimal side effects. Moreover, improvement of fatigue was significantly associated with improved quality of life and decreased levels of depression and psychological distress.
Shared Experiences in Personalized Route Planning (2002)

In this paper we discuss personalized planning (as opposed to personalized information retrieval) where instead of rec-ommending atomic information assets to users, the goal is to construct composite plans that reflect the complex prob-lem solving preferences of users within a particular domain. Specifically, we describe our dual approach to personalized route planning and bring together, for the first time, results to demonstrate the potential of this approach.
Performance Modeling and Characterization of Large Last Level Caches (2012)

Different workloads exhibit different memory footprint and have different dependency on the size and configuration of the memory hierarchy. To quantify the performance implication of various memory system architectures and attributes one needs to understand the program behavior of an application/workload and its use of the memory subsystem. One such architecture studied in this paper is where multiple memory technologies are integrated into the memory system with one (typically the faster, more expensive technology) acting as a large cache for the other (typically a slower, cheaper technology). We develop a large cache prototype to study the performance of different applications and their sensitivity to different architecture parameters. The prototype measures different metrics associated with a cache performance which are in turn used to characterize the performance implications of such a memory architecture on different workloads and the dependency on different configuration parameters.
Advances in the diagnosis and treatment of EBV‐associated lymphoproliferative diseases in immunocompromised hosts (1985)

The clinical, immunopathologic, and virologic features of the lymphoproliferative diseases occurring after renal transplantation have been characterized. Clinically, patients may present with an infectious mononucleosis-like illness or with localized solid tumor masses. These lymphoproliferative diseases have unique histologic features that can be classified as polymorphic diffuse B-cell hyperplasia (PDBH) or polymorphic B-cell lymphoma (PBL). Immunologic cell-typing studies have shown that the majority are polyclonal B-cell proliferations, but monoclonal B-cell tumors have also been documented. These B-cell proliferations may, however, evolve from a benign polyclonal B-cell hyperplasia to a monoclonal malignant lymphoma. The Epstein-Barr virus (EBV) has been implicated as the cause of these disorders. Serologic studies frequently demonstrate evidence of a primary or reactivation infection, touch imprints from involved tissue may stain for the presence of EBNA (Epstein-Barr nuclear antigen), and EBV DNA hybridization studies demonstrate the presence of EBV-specific DNA sequences within tumor cells. Since EBV induces a polyclonal B-cell proliferation in vitro and in vivo, the polyclonality of these diseases also implicates EBV. Acyclovir, a new synthetic antiviral agent that inhibits EBV DNA replication may be effective in some patients during the polyclonal growth phase but is ineffective once the tumor evolves into a monoclonal lymphoma. We have identified several factors that may be useful in predicting responsiveness to acyclovir therapy.
ChemInform Abstract: The Chemistry of Transition Metal Complexes Containing Catechol and Semiquinone Ligands. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.