gebhart/patrepeval huggingface dataset:
Surface-Initiated Ring-Opening Metathesis Polymerization on Si/SiO2 (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSurface-Initiated Ring-Opening Metathesis Polymerization on Si/SiO2Namyong Y. Kim, Noo Li Jeon, Insung S. Choi, Seiichi Takami, Yoshiko Harada, Krista R. Finnie, Gregory S. Girolami, Ralph G. Nuzzo, George M. Whitesides, and Paul E. LaibinisView Author Information Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Department of Chemistry and the Seitz Materials Research Laboratory, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Cite this: Macromolecules 2000, 33, 8, 2793–2795Publication Date (Web):March 31, 2000Publication History Received11 January 2000Published online31 March 2000Published inissue 1 April 2000https://pubs.acs.org/doi/10.1021/ma000046chttps://doi.org/10.1021/ma000046crapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1938Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Polymer films,Polymers,Silicon,Thickness Get e-Alerts
Interactive image-guided neurosurgery (1992)

Interactive image-guided (IIG) surgery involves the synchronal display of the tip of a surgical device on preoperative scans. This display allows the surgeon to locate the present surgical position relative to the final site of surgical interest. A technique for IIG surgery based on a 6-degrees-of-freedom articulated arm is presented. Design accuracy for the arm is less than 0.1 mm, and the present implementation has a submillimetric accuracy. The display can show the surgical position on any tomographic image set with simultaneous display on up to three image sets. Laboratory results and clinical applications are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Oxidative Decarboxylation of Branched-Chain 2-Oxo Fatty Acids by Higher Plant Peroxisomes (1988)

Peroxisomes from mung bean (Vigna radiata L.) hypocotyls catalyze, in the presence of branched-chain 2-oxo fatty acid, CoASH and NAD, the release of CO(2), and the formation of NADH and acyl-CoA. The acyl-CoA contains one carbon atom less than the branched-chain 2-oxo fatty acid and serves as substrate for the peroxisomal acyl-CoA oxidase. CO(2) release, NADH and acyl-CoA formation occur in 1:1:1 stoichiometry. For the first time the data demonstrate directly the oxidative decarboxylation of branched-chain 2-oxo fatty acids in higher plants and a location of this activity in the peroxisomes.
Limitations on quantum ladder climbing in complex systems (1997)

The use of cesium Rydberg atoms as a test system for quantum ladder climbing with chirped laser pulses is described. Quantum ladders can be used in the coherent control of chemical reactions; for instance, by exciting a specific molecular bond by climbing its vibrational ladder. A Rydberg atom is an easy test system because of the large transition dipole moments between Rydberg states. The Rydberg states are easy to access and to analyze. Picosecond far-infrared laser pulses around a wavelength of 50 \ensuremath{\mu}m, with peak intensities of ${10}^{9}{\mathrm{W}/\mathrm{c}\mathrm{m}}^{2},$ from the free-electron laser for infrared experiments (FELIX) at Nieuwegein, The Netherlands, were used. It is found that the complexity of the system puts severe limits on the allowed intensities that are used to drive the ladder. At high intensity the ladder is distorted due to coupling with states outside the ladder. This distortion frustrates efficient climbing.
Lung volumes and forced ventilatory flows (1993)

Lung volumes are subdivided into static and dynamic lung volumes. Static lung volumes are measured by methods which are based on the completeness of respiratory manoeuvres, so that the velocity of the manoeuvres should be adjusted accordingly. The measurements taken during fast breathing movements are described as dynamic lung volumes and as forced inspiratory and expiratory flows.

### 1.1 Static lung volumes and capacities

The volume of gas in the lung and intrathoracic airways is determined by the properties of lung parenchyma and surrounding organs and tissues, surface tension, the force exerted by respiratory muscles, by lung reflexes and by the properties of airways. The gas volumes of thorax and lung are the same except in the case of a pneumothorax. If two or more subdivisions of the total lung capacity are taken together, the sum of the constituent volumes is described as a lung capacity. Lung volumes and capacities are described in more detail in § 2.

#### 1.1.1 Determinants

Factors which determine the size of the normal lung include stature, age, sex, body mass, posture, habitus, ethnic group, reflex factors and daily activity pattern. The level of maximal inspiration (total lung capacity, TLC) is influenced by the force developed by the inspiratory muscles (disorders include e.g. muscular dystrophy), the elastic recoil of the lung (disorders include e.g. pulmonary fibrosis and emphysema) and the elastic properties of the thorax and adjacent structures (disorders include e.g. ankylosis of joints). The level of maximal expiration (residual volume, RV) is determined by the force exerted by respiratory muscles (disorders include e.g. muscle paralysis), obstruction, occlusion and compression of small airways (disorders include e.g. emphysema) and by the mechanical properties of lung and thorax (disorders include diffuse fibrosis, kyphoscoliosis).

Assessing the total lung capacity is indispensable in establishing a restrictive ventilatory defect or in diagnosing abnormal lung distensibility, as may occur in patients …
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory (2005)

Alzheimer's disease (AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies. In total, data from 764 participants were compared across five in vivo imaging methods. Convergence of effects was seen in posterior cortical regions, including posterior cingulate, retrosplenial, and lateral parietal cortex. These regions were active in default states in young adults and also showed amyloid deposition in older adults with AD. At early stages of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior cortical regions; atrophy in medial temporal regions was also observed. Event-related functional magnetic resonance imaging studies further revealed that these cortical regions are active during successful memory retrieval in young adults. One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy. These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
Immunohistochemistry in the diagnosis of neoplasms of the central nervous system. (2000)

The diagnosis and evaluation of neoplasms of the central nervous system frequently involves the use of immunohistochemical stains. This article reviews some of the more commonly used markers including glial fibrillary acidic protein, synaptophysin, neurofilament protein, S-100 protein, epithelial membrane antigen, and cytokeratin markers. The focus of the discussion is on the use of these markers including their utility in resolving differential diagnostic issues. We also review the use of p53 and a variety of cell proliferation markers including proliferating cell nuclear antigen, Ki-67, MIB-1 and their potential role as adjuncts in the grading of tumors and their potential role in predicting tumor behavior.
A phase I study of vaccination with NY‐ESO‐1f peptide mixed with Picibanil OK‐432 and Montanide ISA‐51 in patients with cancers expressing the NY‐ESO‐1 antigen (2011)

We conducted a phase I clinical trial of a cancer vaccine using a 20-mer NY-ESO-1f peptide (NY-ESO-1 91-110) that includes multiple epitopes recognized by antibodies, and CD4 and CD8 T cells. Ten patients were immunized with 600 μg of NY-ESO-1f peptide mixed with 0.2 KE Picibanil OK-432 and 1.25 ml Montanide ISA-51. Primary end points of the study were safety and immune response. Subcutaneous injection of the NY-ESO-1f peptide vaccine was well tolerated. Vaccine-related adverse events observed were fever (Grade 1), injection-site reaction (Grade 1 or 2) and induration (Grade 2). Vaccination with the NY-ESO-1f peptide resulted in an increase or induction of NY-ESO-1 antibody responses in nine of ten patients. The sera reacted with recombinant NY-ESO-1 whole protein as well as the NY-ESO-1f peptide. An increase in CD4 and CD8 T cell responses was observed in nine of ten patients. Vaccine-induced CD4 and CD8 T cells responded to NY-ESO-1 91-108 in all patients with various HLA types with a less frequent response to neighboring peptides. The findings indicate that the 20-mer NY-ESO-1f peptide includes multiple epitopes recognized by CD4 and CD8 T cells with distinct specificity. Of ten patients, two with lung cancer and one with esophageal cancer showed stable disease. Our study shows that the NY-ESO-1f peptide vaccine was well tolerated and elicited humoral, CD4 and CD8 T cell responses in immunized patients.
Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury (2005)

Spinal cord contusion injury (SCI) is known to induce pain-related behaviour, as well as hyperresponsiveness in lumbar dorsal horn nociceptive neurons associated with the aberrant expression of Na(v)1.3, a rapidly repriming voltage-gated sodium channel. Many of these second-order dorsal horn neurons project to third-order neurons in the ventrobasal complex of the thalamus. In this study we hypothesized that, following SCI, neurons in the thalamus undergo electrophysiological changes linked to aberrant expression of Na(v)1.3. Adult male Sprague-Dawley rats underwent contusion SCI at the T9 thoracic level. Four weeks post-SCI, Na(v)1.3 protein was upregulated within thalamic neurons in ventroposterior lateral (VPL) and ventroposterior medial nuclei, where extracellular unit recordings revealed increased spontaneous discharge, afterdischarge, hyperresponsiveness to innocuous and noxious peripheral stimuli, and expansion of peripheral receptive fields. Altered electrophysiological properties of VPL neurons persisted after interruption of ascending spinal barrage by spinal cord transection above the level of the injury. Lumbar intrathecal administration of specific antisense oligodeoxynucleotides generated against Na(v)1.3 caused a significant reduction in Na(v)1.3 expression in thalamic neurons and reversed electrophysiological alterations. These results show, for the first time, a change in sodium channel expression within neurons in the thalamus after injury to the spinal cord, and suggest that these changes contribute to altered processing of somatosensory information after SCI.
IMMUNE REACTION OF SPECIFIC SERUM ANTIBODIES TO PORPHYROMONAS ENDODONTALIS ANTIGEN IN PATIENTS WITH PERIAPICAL LESION (1994)

Porphyromonas endodontalis is a black-pigmented anaerobic Gram-negative rod which is associated with endodontal infections and this microorganism possesses a potential for pathogenicity. The purpose of this study was to compare the membrane components of Porphyromonas endodontalis and Porphyromonas gingivalis and to study the immune reaction patterns of Porphyromonas endodontalis with patients with periapical lesion. Porphyromonas endodontalis (ATCC 35406), Porphyromonas gingivals serotypea (381), serotype b(W50), serotype c(A7A1-28) were cultured in anaerobic condition. Rabbit antisera were prepared by intravenous injection of formalized whole cells and human sera were obtained from patients and dental students. Indirect immunofluorescence method was used to study on the cross reaction between Porphyromonas endodontalis and Porphyromonas gingivalis serotype a, b, c antigen. Total membrane protein profiles of Porphyromonas endodontalis antigen were studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis and the reactivity of antigenic components of Porphyromonas endodontalis against sera of patients and rabbit anti-Porphyromonas endodontalis antisera were assessed by Immunoblotting method. The following results were obtained : 1. Antigens of Porphyromonas endodontalis has multiple antigenic components, and both patients with periapical lesion and normal healthy individual showed immune response to this. 2. Patients group and healthy individual group showed a diversity of immune reaction pattern but they showed immune response against 43kd protein. 3. Patients with periapical lesion showed more diverse immune response than healthy individual and in some patients, much more bands appeared to lower molecular weight protein. 4. According to indirect immunofluorescence and Immunoblotting study, Porphyromonas endodontalis did not share common antigen with Porphyromonas gingivalis serotype a, b, c.
Synthesis of Transportation Fuels from Biomass:  Chemistry, Catalysts, and Engineering (2006)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Transportation Fuels from Biomass: Chemistry, Catalysts, and EngineeringGeorge W. Huber, Sara Iborra, and Avelino CormaView Author Information Instituto de Tecnología Químicia, UPV-CSIC, Universidad Politénica de Valencia, Avda. de los Naranjos, s/n, Valencia, Spain Cite this: Chem. Rev. 2006, 106, 9, 4044–4098Publication Date (Web):June 27, 2006Publication History Received3 February 2006Published online27 June 2006Published inissue 1 September 2006https://pubs.acs.org/doi/10.1021/cr068360dhttps://doi.org/10.1021/cr068360dresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views61161Altmetric-Citations6513LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alcohols,Biofuels,Biomass,Catalysts,Fossil fuels Get e-Alerts
Characterisation of a complementary DNA encoding a novel plant enzyme with sucrolytic activity (1994)

The cloning of a 1332 bp cDNA from a potato (Solanum tuberosum L.) cv. Cara leaf cDNA expression library, using an antibody raised against a purified tuber protein preparation with sucrolytic activity, is described. The corresponding gene in potato is of low copy number, is expressed in a variety of tissues, and encodes a protein which includes several domains with similarity to database sequences, including ferredoxin from Clostridium pasteurianum. Expression of the cDNA in E. coli yields a fusion protein with sucrolytic activity.
Fast, accurate, and precise mapping of the RF field in vivo using the 180° signal null (2007)

RF field B1 nonuniformity is the largest cause of error in the quantitative measurement of many clinically relevant parameters in MR images and spectra. Knowledge of the absolute flip angles at every region will improve the accuracy and precision of such parameters. This method uses the 180 degrees signal null to construct a flip angle map of the entire brain in less than 4 min, independent of T1, T2, and proton density. Three spoiled gradient echo volume acquisitions of the whole brain were made with three different flip angles. The optimum choice of flip angles was determined to be 145 degrees, 180 degrees, and 215 degrees. Linear regression analysis was used to determine the nominal (system calibrated) flip angle required for a signal null at every pixel and thence determine the absolute flip angle at that location. The experiment utilizes an existing MR sequence supplied by the scanner manufacturer. The technique is validated experimentally and a theoretical investigation into the optimum experimental parameters is presented.
Preparation of Superconducting Y-Ba-Cu-O Thick Film (1988)

During sintering, superconducting copper-oxide films commonly have a high chemical activity with substrate materials, which results in poor superconductivity. In this research, the substrate is prepared by coating multiple non-superconducting Y-Ba-Cu-O films on alumina. The superconducting Y-Ba-Cu-O thick films were prepared by mixing powders Y 2 O 3 , BaCO 3 and CuO, making a paste by mixing this noncalcined mixture with solvent, coating it on to a film-coated substrate using a painting or printing method, and then sintering the specimen. The thick films have positive superconductive characteristics at high temperatures.
Regular Mesh Topologies in Local and Metropolitan Area Networks (1985)

The throughput per user in loop and bus configured local area networks decreases linearly with the number of users. These networks cannot be extended to a metropolitan area with many users. A class of mesh networks is described that increases the throughput of conventional local area networks by decreasing the fraction of the network capacity needed to transmit information between a source and a destination. These networks have multiple paths that increase the reliability of the networks, and have point-to-point links that can cover a metropolitan area. In general, mesh networks require complex store-and-forward nodes that also route messages, control the flow of data entering the network, resequence packets at the destination, and recover packets with errors. However, there are characteristics of the local or metropolitan area that allow these functions to be simplified. As a result of these simplifications, loop access protocols are extended to mesh networks and the need to store and forward data is eliminated. A file transfer protocol that does not require packet resequencing is described. Three mesh networks are studied, and the desirable characteristics of networks are determined. One network, the Manhattan street network, has many of the desirable characteristics.
Using intelligent agents to manage business processes (1996)

This paper describes work undertaken in the ADEPT (Advanced Decision Environment for Process Tasks) project towards developing an agent-based infrastructure for managing business processes.We describe how the key technology of negotiating, service providing, autonomous agents was realised and demonstrate how this was applied to the BT business process of providing a customer quote for network services.1.This is one of the major features which distinguishes multi-agent systems from more traditional forms of distributed processing [16]. Intelligent
Optimization of HNO Production from N , O - bis -Acylated Hydroxylamine Derivatives (2011)

A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.
Diffusion MRI: A New Strategy for Assessment of Cancer Therapeutic Efficacy (2002)

The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator or treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention may be heterogeneous. The use of imaging could assist in delineating therapeutic-induced spatial heterogeneity within a tumor mass by providing information related to specific regions that are resistant or responsive to treatment. Largely untapped potential resides in exploratory methods such as diffusion MRI, which is a nonvolumetric intravoxel measure of tumor response based upon water molecular mobility. Alterations in water mobility reflect changes in tissue structure at the cellular level. While the clinical utility of diffusion MRI for oncologic practice is still under active investigation, this overview on the use of diffusion MRI for the evaluation of brain tumors will serve to introduce how this approach may be applied in the future for the management of patients with solid tumors.
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma (2008)

Following TBI, neuron use initially increases, with subsequent depletion of extracellular glucose, resulting in increased levels of extracellular lactate and pyruvate. This energy requirement can result in cell death due to increased metabolic demands. These data suggest that the neuroprotective effect of EPO may be partially due to improved energy metabolism in the acute phase in this rat model of TBI.