gebhart/patrepeval huggingface dataset:
Iron deficiency anemia: evaluation and management. (2013)

Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal. Women should be screened during pregnancy, and children screened at one year of age. Supplemental iron may be given initially, followed by further workup if the patient is not responsive to therapy. Men and postmenopausal women should not be screened, but should be evaluated with gastrointestinal endoscopy if diagnosed with iron deficiency anemia. The underlying cause should be treated, and oral iron therapy can be initiated to replenish iron stores. Parenteral therapy may be used in patients who cannot tolerate or absorb oral preparations.
Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte (2010)

We report the outcome of patients included in the LNH-98.5 study, which compared cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) to rituximab plus CHOP (R-CHOP) therapy in 399 patients with diffuse large B-cell lymphoma (DLBCL) aged 60 to 80 years, with a median follow-up time of 10 years. Clinical event information was updated in all living patients (with the exception of 3 patients) in 2009. Survival end points were improved in patients treated with R-CHOP: the 10-year progression-free survival was 36.5%, compared with 20% with CHOP alone, and the 10-year overall survival was 43.5% compared with 27.6%. The same risk of death due to other diseases, secondary cancers, and late relapses was observed in both study arms. Relapses occurring after 5 years represented 7% of all disease progressions. The results from the 10-year analysis confirm the benefits and tolerability of the addition of rituximab to CHOP. Our findings underscore the need to treat elderly patients as young patients, with the use of curative chemotherapy.
Next-Generation Sequencing for Clinical Diagnostics (2013)

Yang et al.1 report in the Journal the results of using whole-exome sequencing to make a molecular diagnosis in 62 of 250 cases (25%) sequenced by the clinical sequencing laboratory at the Baylor College of Medicine, which is accredited by the College of American Pathologists and certified through the Clinical Laboratory Improvement Amendments program. This level of success is a marked improvement over that obtained by testing single genes or gene panels currently used in standard care. The exome is the portion of the genome known to encode proteins (approximately 1% of the human genome2). Whole-exome sequencing has the . . .
Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease? (2005)

The diagnostic accuracy of MCI criteria used in trials for predementia Alzheimer's disease is low to moderate. Their use may lead to inclusion of many patients who do not have predementia Alzheimer's disease or to exclusion of many who do. Subjects with moderately severe depression should not be excluded from trials in order not to reduce the sensitivity.
Quantitation of Murine and Human Hematopoietic Stem Cells by Limiting-Dilution Analysis in Competitively Repopulated Hosts (2003)

In designing functional assays for the various classes of hematopoietic cells described in this book, one needs to consider the properties of the cell to be measured which must be incorporated into the assay design, and the end points to allow its specific detection. The most primitive hematopoietic stem cells (HSC) in mouse and man are characterized by two cardinal properties that distinguish them from more mature clonogenic cells and their terminally differentiated progeny. Firstly, HSCs are pluripotent: they are characterized by the potential to differentiate into all of the eight major lineages of lymphoid, myeloid, and erythroid cells in vivo (1-3). Secondly, HSCs are able to self-renew, or generate daughter stem cells in vivo and in vitro that are functionally identical to the stem cell that gave rise to them (3-5). These hallmark properties of HSCs are measured empirically by their potential to regenerate and maintain lymphocytes, granulocytes, and erythrocytes upon transplantation into lethally irradiated or immunocompromised primary and secondary hosts. However, functional assays for primitive HSCs must also consider the fact that differentiated cells present in the hematopoietic organs at different times after bone marrow transplantation are derived from different types of precursors (6), and particularly at later times, cannot be assumed to be of donor origin (7). Support for this concept derives from the relatively recent demonstration in mice that most, if not all, spleen colonies detectable ≈ 2 wk after transplantation originate.
The impaired immune regulation of autoimmune hepatitis is linked to a defective galectin-9/tim-3 pathway (2012)

Reduced levels of Tim-3 on CD4(pos) CD25(neg) effector cells and of Gal9 in T-regs contribute to impaired immunoregulation in AIH by rendering effector cells less prone to T-reg control and T-regs less capable of suppressing.
Periodontal disease in research beagle dogs – an epidemiological study (2008)

Periodontal disease in terms of clinical attachment loss greater than equal to 1 mm and pocket depth greater than equal to 4 mm is common in beagle dogs, but the major disease burden is carried by only a few dogs. The prevalence increases with increased age but is high already at the age of two years.
Activation of Hepatic Stem Cell Marker EpCAM by Wnt–β-Catenin Signaling in Hepatocellular Carcinoma (2007)

The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Using a gene expression profiling approach, we recently identified a novel prognostic HCC subtype that resembles hepatic progenitor cells with the activation of stem cell markers and Wnt-beta-catenin signaling, based on EpCAM (epithelial cell adhesion molecule, a hepatic stem cell marker) expression. In this study, we investigated whether the activation of the Wnt-beta-catenin pathway regulates EpCAM expression. We found that nuclear accumulation of beta-catenin induced, whereas the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation reduced EpCAM gene expression in cultured normal human hepatocytes and HCC cell lines. We identified two Tcf binding elements in the EpCAM promoter that specifically bound to Tcf-4 in an electrophoretic mobility shift assay. EpCAM promoter luciferase activity was down-regulated by the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation. Furthermore, we found that EpCAM-positive HCC is much more sensitive to Tcf/beta-catenin binding inhibitors than EpCAM-negative HCC in vitro. Taken together, our data indicate that EpCAM is a Wnt-beta-catenin signaling target gene and may be used to facilitate HCC prognosis by enabling effective stratification of patients with predicted pharmacologic responses to Wnt-beta-catenin signaling antagonists.
Modeling peripheral nerve stimulation using magnetic fields. (1997)

The technique of magnetic stimulation (MS) has the potential to contribute to the study of the peripheral nervous system, but the uncertainty of the site of activation and problems in achieving supramaximal responses have prevented its extensive use. This paper discusses mathematical modeling of MS of the peripheral nerves. The work reveals recent theoretical advances, which may give new insight to the exact site of activation and help to understand the phenomena involved. The mechanisms of stimulation are examined: a solid comprehension of the stimulation event may boost new applications of the technique.
CACAO — A 64-bit JavaVM just-in-time compiler (1997)

This paper describes the design and implementation of CACAO, a just-in-time compiler for Java. The CACAO system translates Java byte code on demand into native code for the ALPHA processor. During this translation process the stack-oriented Java byte code is transformed into a register-oriented intermediate code. Local variables and stack locations are replaced by pseudo-registers eliminating the 32-bit restriction on address types. A fast register allocation algorithm is applied to map the pseudo-registers to machine registers. During code generation, field offsets are computed for proper alignment on 64-bit architectures. Even though the CACAO system has to incur loading and compilation time, it executes Java programs up to 85 times faster than the JDK interpreter, and up to seven times faster than the kaffe JIT compiler. It is slightly slower than equivalent C programs compiled at the highest optimization level. © 1997 John Wiley & Sons, Ltd.
Adhesions (1992)

Although several decades have passed since the first theories concerning normal healing and adhesion formation processes were proposed, the possible role of some factors is still under investigation. The availability of recombinant murine interleukin-1 allowed the assumption that interleukin-1 may be an important short-term mediator of adhesion formation. The definite effect of prostaglandin E2 on adhesion formation was also further elucidated, whereas prostaglandin F2α was found to play a minimal role in the inflammatory process, which is the initial step in the pathogenesis of adhesions. The development of recombinant tissue plasminogen activator offers a unique alternative to augment the depressed endogenous fibrinolytic system. Intraperitoneal application of recombinant tissue plasminogen activator to injured animal models showed significant reduction in both de novo and reformation of adhesions. The presumption that operative laparoscopy is more beneficial than laparotomy with regard to postoperative adhesion development is demonstrated by the latest studies on this topic. Recently developed barrier methods, including natural or synthetic materials, have been tested in animal models and appear promising in reducing both formation and reformation of adhesions. Until these are introduced in clinical practice, the immediate future will certainly involve the further expansion of absorbable barriers.
RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS (1996)

Natural killer cells are likely to play an important role in the host defenses because they kill virally infected or tumor cells but spare normal self-cells. The molecular mechanism that explains why NK cells do not kill indiscriminately has recently been elucidated. It is due to several specialized receptors that recognize major histocompatibility complex (MHC) class I molecules expressed on normal cells. The lack of expression of one or more class I alleles leads to NK-mediated target cell lysis. During NK cell development, the class I-specific receptors have adapted to self-class I molecules on which they recognize epitopes shared by groups of class I alleles. As such, they may fail to recognize either self-molecules that bound unusual peptides or allogeneic class I molecules unrelated to self-alleles. Different types of receptors specific for groups of HLA-C or HLA-B alleles have been identified. While in most instances, they function as inhibiting receptors, an activating form of the HLA-C-specific receptors has been identified in some donors. Molecular cloning of HLA-C- and HLA-B-specific receptors has revealed new members of the immunoglobulin superfamily with two or three Ig-like domains, respectively, in their extracellular portion. While the inhibiting form is characterized by a long cytoplasmic tail associated with a nonpolar transmembrane portion, the activating one has a short tail associated with a Lys-containing transmembrane portion. Thus, these human NK receptors are different from the murine Ly49 that is a type II transmembrane protein characterized by a C type lectin domain. A subset of cytolytic T lymphocytes expresses NK-type class I-specific receptors. These receptors exert an inhibiting activity on T cell receptor-mediated functions and offer a valuable model to analyze the regulatory mechanisms involved in receptor-mediated cell activation and inactivation.
Optimal multisine excitation design for broadband electrical impedance spectroscopy (2011)

Electrical impedance spectroscopy (EIS) can be used to characterize biological materials in applications ranging from cell culture to body composition, including tissue and organ state. The emergence of cell therapy and tissue engineering opens up a new and promising field of application. While in most cases classical measurement techniques based on a frequency sweep can be used, EIS based on broadband excitations enables dynamic biological systems to be characterized when the measuring time and injected energy are a constraint. Myocardial regeneration, cell characterization in micro-fluidic systems and dynamic electrical impedance tomography are all examples of such applications. The weakness of such types of fast EIS measuring techniques resides in their intrinsic loss of accuracy. However, since most of the practical applications have no restriction over the excitation used, the input power spectrum can be appropriately designed to maximize the accuracy obtained from the measurements. This paper deals with the problem of designing the optimal multisine excitation for electrical bioimpedance measurements. The optimal multisine is obtained by the minimization of the Cramer–Rao lower bound, or what is the same, by maximizing the accuracy obtained from the measurements. Furthermore, because no analytical solution exists for global optimization involving time and frequency domains jointly, this paper presents the multisine optimization approach partially in both domains and then combines the results. As regards the frequency domain approach, a novel contribution is made for the multisine amplitude power spectrum. In the time domain, multisine is optimized by reducing its crest factor. Moreover, the impact on the information and accuracy of the impedance spectrum obtained from using different multisine amplitude power spectra is discussed, as well as the number of frequencies and frequency distributions. The theory is supported by a set of validation measurements when exciting with the optimal and flat multisine signals and compared to a single frequency ac impedance analyzer when characterizing an RC circuit. In vivo healthy myocardium tissue electrical impedance measurements show that broadband EIS based on multisine excitations enable the characterization of dynamic biological systems.
Pyoderma gangrenosum complicating Felty's syndrome. (1990)

The case of a 54-year-old woman with Felty's syndrome whose course was complicated by mucocutaneous lesions clinically typical of pyoderma gangrenosum is described. Necrotizing sinusitis and saddle nose deformity were distinctive clinical features. Lymphocytic vasculitis and rheumatoid nodule formation observed within panniculus at the base of a cutaneous lesion and in a nasal mucosal lesion were unexpected histopathologic findings.
A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses (2004)

A simple generic peptide-based vaccine structure that targets Toll-like receptor 2-expressing dendritic cells and causes their activation is described. The vaccines are totally synthetic, serve as their own adjuvant, and are composed of (i) a single helper T cell epitope, (ii) a target epitope that is either recognized by CD8+ T cells or B cells, and (iii) a Toll-like receptor 2-targeting lipid moiety, S-[2,3-bis(palmitoyloxy)propyl]cysteine, that is situated between the peptide epitopes to form a branched configuration. The different CD8+ T cell epitopes examined were from (i) influenza virus, (ii) the intracellular bacterium Listeria monocytogenes, and (iii) ovalbumin as a model tumor antigen. Vaccines containing a B cell epitope from gastrin or luteinizing hormone-releasing hormone as a B cell epitope were also examined for their ability to elicit antibody against the parent hormones. Each of the vaccines was capable of inducing either CD8+ T cell or antibody-mediated immune responses. The lipidated vaccines, but not the nonlipidated vaccines, were able to mediate protection against viral or bacterial infection and mediate prophylactic and therapeutic anticancer activity. The two hormone-based vaccines induced high antibody titers, which in the case of luteinizing hormone-releasing hormone resulted in abrogation of reproductive function. These results highlight the utility of simple, totally synthetic, epitope-based vaccines.
Pup: An Internetwork Architecture (1980)

Pup is the name of an internet packet format (PARC Universal Packet), a hierarchy of protocols, and a style of internetwork communication. The fundamental abstraction is an end-to-end media-in dependent internetwork datagram. Higher levels of functionality are achieved by end-to-end protocols that are strictly a matter of agreement among the communicating end processes. This report explores important design issues, sets forth principles that have guided the Pup design, discusses the present implementation in moderate detail, and summarizes experience with an operational internetwork. This work serves as the basis for a functioning internetwork system that provides service to about 1000 computers, on 25 networks of 5 different types, using 20 internetwork gateways.
The Measurement of Life Satisfaction (1961)

Journal Article The Measurement of Life Satisfaction Get access Bernice L. Neugarten, Ph.D., Bernice L. Neugarten, Ph.D. Committee on Human Development; University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Havighurst, Ph.D., Robert J. Havighurst, Ph.D. Committee on Human Development; University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Sheldon S. Tobin, M.A. Sheldon S. Tobin, M.A. Committee on Human Development; University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Gerontology, Volume 16, Issue 2, April 1961, Pages 134–143, https://doi.org/10.1093/geronj/16.2.134 Published: 01 April 1961
Using Citation Analysis to Assess the Impact of Journals and Articles on Contemporary Accounting Research (CAR) (1985)

Citation analysis has been used in the natural and social sciences for such purposes as evaluating the research contributions of articles, journals, institutions, and individuals (Garfield [1979]). Some specific applications of the technique to the social sciences include measuring the exchange of information within the management sciences (Back [1974]), predicting Nobel Laureates in economics (Quandt [1976]), appraising journals in psychology (White and White [1977]), evaluating the impact of marketing scholars and academic institutions (Robinson and Adler [1981]), and assessing the relative impacts of economics journals (Liebowitz and Palmer [1984]). Citation analysis has also been used on two occasions in the accounting discipline by McRae [1974] and Dyckman and Zeff [1984], but for somewhat more specific purposes than assessing contributions to accounting research in general. For example, McRae [1974] attempted to define the accounting information network based on a citation analysis of the flow of messages
Trade liberalization, growth and poverty reduction - the case of Bangladesh (2004)

The paper seeks to compile evidence for the hypothesis that greater trade openness, and associated deregulation is good for growth, and poverty reduction in Bangladesh. At the theoretical level, it can be argued that since Bangladesh is relatively heavily endowed with labor, within the framework of the Hecksher-Ohlin model (1933 and 1949), expansion of international trade opportunities will likely support the growth of labor-intensive export industries, promoting employment, and incomes as per the Stolper-Samuelson Theorem (1941). Arguments also suggest improved productive and allocative efficiency; factor accumulation and investment; knowledge spillovers; improved income distribution; and, government policy improvements. The paper argues, using qualitative and quantitative analysis and a case study approach, that Bangladesh's increasing global integration, based on trade liberalization, and other economic deregulation, especially as of the 90s, contributed significantly to the acceleration of per capita income growth, and poverty reduction. It looks briefly at issues of trade openness, and economic development from the theoretical perspective, reviews the empirical basis for the effects of trade openness on economic development, and, focuses broadly on economic deregulation, and trade liberalization. Policy regimes implications are analyzed to provide a series of observations.
Silencer elements as possible inhibitors of pseudoexon splicing (2004)

Human pre-mRNAs contain a definite number of exons and several pseudoexons which are located within intronic regions. We applied a computational approach to address the question of how pseudoexons are neglected in favor of exons and to possibly identify sequence elements preventing pseudoexon splicing. A search for possible splicing silencers was carried out on a pseudoexon selection that resembled exons in terms of splice site strength and exon splicing enhancer (ESE) representation; three motifs were retrieved through hexamer composition comparisons. One of these functions as a powerful silencer in transfection-based splicing assays and matches a previously identified silencer sequence with hnRNP H binding ability. The other two motifs are novel and failed to induce skipping of a constitutive exon, indicating that they might act as weak repressors or in synergy with other unidentified elements. All three motifs are enriched in pseudoexons compared with intronic regions and display higher frequencies in intronless gene-coding sequences compared with exons. We consider that a subpopulation of pseudoexons might rely on negative regulators for splicing repression; this hypothesis, if experimentally verified, might improve our understanding of exonic splicing regulatory sequences and provide the identification of a novel mutation target for human genetic diseases.
A review of technologies for sensing contact location on the surface of a display (2012)

Abstract Touchscreen interactive devices have become increasingly important in both consumer and commercial applications. This paper provides a broad overview of all touchscreen technologies in use today, organized into 13 categories with 38 variations. The 13 categories are projected capacitive, analog resistive, surface capacitive, surface acoustic wave, infrared, camera‐based optical, liquid crystal display in‐cell, bending wave, force sensing, planar scatter detection, vision‐based, electromagnetic resonance, and combinations of technologies. The information provided on each touchscreen technology includes a little history, some basic theory of operation, the most common applications, the key advantages and disadvantages, a few current issues or trends, and the author's opinion of the future outlook for the technology. Because of its dominance, this paper begins with projected capacitive; more information is provided on this technology than on any of the other touch technologies that are discussed. This paper covers only technologies that operate by contact with a display screen; this excludes technologies such as 3D gesture recognition, touch on opaque devices such as interactive whiteboards, and proximity sensing. This is not a highly technical paper; it sacrifices depth of information on any one technology for breadth of information on multiple technologies.