gebhart/patrepeval huggingface dataset:
Biophysical mechanisms of phase contrast in gradient echo MRI (2009)

Recently reported contrast in phase images of human and animal brains obtained with gradient-recalled echo MRI holds great promise for the in vivo study of biological tissue structure with substantially improved resolution. Herein we investigate the origins of this contrast and demonstrate that it depends on the tissue "magnetic architecture" at the subcellular and cellular levels. This architecture is mostly determined by the structural arrangements of proteins, lipids, non-heme tissue iron, deoxyhemoglobin, and their magnetic susceptibilities. Such magnetic environment affects/shifts magnetic resonance (MR) frequencies of the water molecules moving/diffusing in the tissue. A theoretical framework allowing quantitative evaluation of the corresponding frequency shifts is developed based on the introduced concept of a generalized Lorentzian approximation. It takes into account both tissue architecture and its orientation with respect to the external magnetic field. Theoretical results quantitatively explain frequency contrast between GM, WM, and CSF previously reported in motor cortex area, including the absence of the contrast between WM and CSF. Comparison of theory and experiment also suggests that in a normal human brain, proteins, lipids, and non-heme iron provide comparable contributions to tissue phase contrast; however, the sign of iron and lipid contributions is opposite to the sign of contribution from proteins. These effects of cellular composition and architecture are important for quantification of tissue microstructure based on MRI phase measurements. Also theory predicts the dependence of the signal phase on the orientation of WM fibers, holding promise as additional information for fiber tracking applications.
Scalable multihop WDM passive ring with optimal wavelength assignment and adaptive wavelength routing (1996)

Ring networks have drawn wide attention due to token ring and FDDI standards. This paper presents a scalable multihop WDM passive ring architecture for local area or metropolitan area networks. The network consists of optical interfaces, which are connected into a ring by fibers. Each optical interface is completely passive and unpowered. We apply the "multihop" principle by introducing a regular multiloop ring called "wheel" as the optical connectivity and embedding it onto a single-loop fiber ring. Each network access node requires only a small number of fixed-tuned transceivers and an ATM switch. The network can incrementally scale up from a smaller ring to a larger ring by deploying more access nodes and optical interfaces. When scaling up the network, not only the number of wavelengths required is small but also no more wavelengths are required. This architecture has an excellent ability for alternative routing and optimal wavelength reuse. We present three distributed adaptive wavelength routing algorithms and an optimal wavelength assignment algorithm which minimizes the number of wavelengths used. A method yielding the lowest possible call blocking probability for an "ideal" network with a fixed number of transceivers per node is presented and used as a yardstick to evaluate the proposed networks. The numerical results show that the architecture is very efficient.
Syntax or semantics? knowledge-guided joint semantic frame parsing (2016)

Spoken language understanding (SLU) is a core component of a spoken dialogue system, which involves intent prediction and slot filling and also called semantic frame parsing. Recently recurrent neural networks (RNN) obtained strong results on SLU due to their superior ability of preserving sequential information over time. Traditionally, the SLU component parses semantic frames for utterances considering their flat structures, as the underlying RNN structure is a linear chain. However, natural language exhibits linguistic properties that provide rich, structured information for better understanding. This paper proposes to apply knowledge-guided structural attention networks (K-SAN), which additionally incorporate non-flat network topologies guided by prior knowledge, to a language understanding task. The model can effectively figure out the salient substructures that are essential to parse the given utterance into its semantic frame with an attention mechanism, where two types of knowledge, syntax and semantics, are utilized. The experiments on the benchmark Air Travel Information System (ATIS) data and the conversational assistant Cortana data show that 1) the proposed K-SAN models with syntax or semantics outperform the state-of-the-art neural network based results, and 2) the improvement for joint semantic frame parsing is more significant, because the structured information provides rich cues for sentence-level understanding, where intent prediction and slot filling can be mutually improved.
Randomized Clinical Trial of Interceptive and Comprehensive Orthodontics (2012)

Focusing public insurance programs on interceptive orthodontics (IO) may increase access for low-income children. This report presents outcomes from a randomized clinical trial (RCT) comparing IO with comprehensive orthodontics (CO) in Medicaid patients. One hundred seventy pre-adolescents with Medicaid-eligible malocclusions were randomized to IO (n = 86) followed by observation (OBS) or OBS followed by CO (n = 84). One hundred thirty-four completed the trial. Models at pre-treatment (baseline) and following ≤ 2 years of intervention and 2 years of OBS (48 mos) were scored by calibrated examiners using the Peer Assessment Rating (PAR) and Index of Complexity, Outcome and Need (ICON). Overall outcomes and clinically meaningful categorical ICON data on need/acceptability, complexity, and improvement were compared. At baseline, groups were balanced by age, gender, ethnicity, and PAR/ICON scores. Most were minorities. Most (77%) were rated as difficult-to-very difficult. Scores improved significantly for both groups, but CO more than IO (PAR, 18.6 [95%CI 15.1, 22.1] vs.10.1 [95%CI 6.7, 13.4]; ICON, 44.8 [95% CI 39.7, 49.9] vs. 35.2 [95%CI 29.7, 40.6], respectively). On average, IO is effective at reducing malocclusions in Medicaid patients, but less than CO. (ClinicalTrials.gov number CT00067379).
Modeling and performance analysis of BitTorrent-like peer-to-peer networks (2004)

In this paper, we develop simple models to study the performance of BitTorrent, a second generation peer-to-peer (P2P) application. We first present a simple fluid model and study the scalability, performance and efficiency of such a file-sharing mechanism. We then consider the built-in incentive mechanism of BitTorrent and study its effect on network performance. We also provide numerical results based on both simulations and real traces obtained from the Internet.
Introduction (2006)

Abstract This introductory chapter discusses the purpose of the book and its scope of analysis relative to the extent, pattern, and character of capital formation and its contribution to Korea's three stages of economic development and transformation. It identifies the reasons why the study of capital formation and economic transformation in Korea during the 70-year period is essential to understanding the path of the country's economic transformation. The chapter emphasizes the three major groups of players in Korea, namely, the Koreans, the Japanese, and foreigners (those other than Japanese and Korean nationals) whose role or lack of role was significant. The approach followed in this study is more behavioral and analytical than historical; the nature of the sources of data used in this book is also noted.
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy (2015)

Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive enzyme in human tumors, leads to immune evasion and tumor tolerance. IDO is therefore a tumor immunotherapeutic target, and several IDO inhibitors are currently undergoing clinical trials. IDO inhibitors can enhance the efficacy of common cancer chemotherapeutics. Here we investigate Pt(IV)-(D)-1-methyltryptophan conjugates 1 and 2 for combined immunomodulation and DNA cross-link-triggered apoptosis for cancer "immuno-chemotherapy". Compound 2 effectively kills hormone-dependent, cisplatin-resistant human ovarian cancer cells, inhibiting IDO by transcriptional deregulation of the autocrine-signaling loop IDO-AHR-IL6, which blocks kynurenine production and promotes T-cell proliferation. Additionally, 1 and 2 display low toxicity in mice and are stable in blood. To our knowledge, this construct is the first Pt drug candidate with immune checkpoint blockade properties.
Critical Kinetics of Volume Phase Transition of Gels (1985)

The volume phase transition of submillimeter spherical isopropylacrylamide gels shows critical kinetic behavior near the critical point; the transition takes an infinite time, and the thermal expansion becomes infinitely large. At the critical point the gels also undergo internal critical density fluctuations as revealed by photon-correlation spectroscopy. The observation of critical kinetics along with critical dynamics clarifies the physical principle of the kinetics of gel volume change.
New recursive-least-squares algorithms for nonlinear active control of sound and vibration using neural networks (2001)

In recent years, a few articles describing the use of neural networks for nonlinear active control of sound and vibration were published. Using a control structure with two multilayer feedforward neural networks (one as a nonlinear controller and one as a nonlinear plant model), steepest descent algorithms based on two distinct gradient approaches were introduced for the training of the controller network. The two gradient approaches were sometimes called the filtered-x approach and the adjoint approach. Some recursive-least-squares algorithms were also introduced, using the adjoint approach. In this paper, an heuristic procedure is introduced for the development of recursive-least-squares algorithms based on the filtered-x and the adjoint gradient approaches. This leads to the development of new recursive-least-squares algorithms for the training of the controller neural network in the two networks structure. These new algorithms produce a better convergence performance than previously published algorithms. Differences in the performance of algorithms using the filtered-x and the adjoint gradient approaches are discussed in the paper. The computational load of the algorithms discussed in the paper is evaluated for multichannel systems of nonlinear active control. Simulation results are presented to compare the convergence performance of the algorithms, showing the convergence gain provided by the new algorithms.
Lidocaine for the alleviation of pain associated with subcutaneous erythropoietin injection. (1994)

Alon, U S; Allen, S; Rameriz, Z; Warady, B A; Kaplan, R A; Harris, D J Author Information
A selective fluorescent ratiometric chemodosimeter for mercury ion (2005)

A selective fluorescent chemodosimeter for mercury ion based on the mercury-promoted intramolecular cyclic guanylation of thiourea connected on 1, 8-naphthalimide is described.
Coating Uniformity: Influence of Atomizing Air Pressure (2003)

The objective of this study was to investigate the influence of atomizing air pressure on the coating uniformity and the quality of the film coat. As parameters describing the coating uniformity, the mass variance of the film coated tablets and the variance of the film thickness within a tablet were used. For the examination of the properties of the film coat, the cumulative frequency of the tablet mass, the spray loss, the relative frequency of the film thickness, the minimum amount of polymer required for an enteric coating, and the swelling number were taken into consideration. For this study a Walther Pilot spray gun WA 50 with a liquid orifice diameter of 0.5 mm and a flat jet air cap was used. The experiments were carried out in a Bohle BLC 5 drum coater using four different atomizing air pressures between 0.5 and 2.0 bar. All other parameters were kept constant during the coating process. It could be shown that atomizing air pressure is an important factor influencing the quality and uniformity of a film coat. An increase in the atomizing air pressure will produce smooth tablets with a small mass variance. Due to a greater spray loss, the required minimum amount of polymer for an enteric coating is higher at an atomizing air pressure of 2.0 bar.
Does activation of the TAL1 gene occur in a majority of patients with T- cell acute lymphoblastic leukemia? A pediatric oncology group study (1995)

Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL. In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration. A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells. Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement. In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion. Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles).
Hammett Analysis of Selective Thyroid Hormone Receptor Modulators Reveals Structural and Electronic Requirements for Hormone Antagonists (2005)

Selective thyroid hormone modulators that function as isoform-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically useful in diseases associated with aberrant hormone signaling. The most potent thyroid hormone antagonist reported to date is NH-3. To explore the significance of the 5'-p-nitroaryl moiety of NH-3 and understand what chemical features are important to confer antagonism, we sought to expand the structure-activity relationship data for the class of 5'-phenylethynyl GC-1 derivatives. Herein, we describe an improved synthetic route utilizing palladium-catalyzed chemistry for efficient access to a series of 5'-phenylethynyl compounds with varying size and electronic properties. We prepared and tested sixteen analogues for TR binding and transactivation activity. Substitution at the 5'-position decreased binding affinity, but retained TRbeta-selectivity. In transactivation assays, the analogues displayed a spectrum of agonist, antagonist, and mixed agonist/antagonist activity that correlated with electronic character in a Hammett analysis between sigma substituent value and TR modulation. Analogues NH-5, NH-7, NH-9, NH-11, and NH-23 displayed full antagonist activity with reduced potency compared to NH-3, indicating the nitro group is not required for antagonism. However, para-substitution with strong electron withdrawing properties on the 5'-aryl extension is important for antagonist activity, and antagonist potency-but not ligand receptor binding-was found to correlate linearly with the sigma values for the electron withdrawing substituents.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. (1990)

Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic GMP. Its enzymatic formation from arginine by a soluble enzyme associated with stoichiometric production of citrulline requires NADPH and Ca2+. We show that nitric oxide synthetase activity requires calmodulin. Utilizing a 2',5'-ADP affinity column eluted with NADPH, we have purified nitric oxide synthetase 6000-fold to homogeneity from rat cerebellum. The purified enzyme migrates as a single 150-kDa band on SDS/PAGE, and the native enzyme appears to be a monomer.
Comparison of two infrared devices in their effectiveness in reducing symptoms associated with RLS (2010)

This study was conducted to assess whether two kinds of near-infrared light devices, using different wavelengths and frequencies, impact symptoms associated with restless legs syndrome (RLS) differently. A recent randomized controlled study showed that symptoms associated with RLS can be diminished with near-infrared light treatment for a limited time. We wanted to assess whether different wavelengths and frequencies had an impact on its effectiveness. Twenty-five volunteers with symptoms of RLS were randomly assigned to either Anodyne® or HealthLight™ treatment. Both groups underwent 12 treatments with near-infrared light, three times a week for 4 weeks. A validated RLS rating scale was used to track changes. The two groups were not different in reported symptoms at baseline (p=0.37) and after 4 weeks of treatment (p=0.88). There was a significant improvement of symptoms between week 0 and week 4 (p<0.001); the difference in change indicated virtually the same improvement between the two groups. Although the two near-infrared light devices used different wavelengths and frequencies and one device used additional red light, they both produced significant improvement in the symptoms associated with RLS after 4 weeks of treatment.
High-frequency ultrasound scattering from microspheres and single cells (2005)

Assessing the proportion of biological cells in a volume of interest undergoing structural changes, such as cell death, using high-frequency ultrasound (20-100 MHz), requires the development of a theoretical model of scattering by any arbitrary cell ensemble. A prerequisite to building such a model is to know the scattering by a single cell in different states. In this paper, a simple model for the high-frequency acoustic scattering by one cell is proposed. A method for deducing the backscatter transfer function from a single, subresolution scatterer is also devised. Using this method, experimental measurements of backscatter from homogeneous, subresolution polystyrene microspheres and single, viable eukaryotic cells, acquired across a broad, continuous range of frequencies were compared with elastic scattering theory and the proposed cell scattering model, respectively. The resonant features observed in the backscatter transfer function of microspheres were found to correspond accurately to theoretical predictions. Using the spacing of the major spectral peaks in the transfer functions obtained experimentally, it is possible to predict microsphere diameters with less than 4% error. Such good agreement was not seen between the cell model and the measured backscatter from cells. Possible reasons for this discrepancy are discussed.
A Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugs (2006)

A broad overview is presented describing the current knowledge and the ongoing research concerning the 4-aminoquinolines (4AQ) as chemotherapeutic antimalarial agents. Included are discussions of mechanism of action, structure activity relationships (SAR), chemistry, metabolism and toxicity and parasite resistance mechanisms. In discussions of SAR, particular emphasis has been given to activity versus chloroquine resistant strains of Plasmodium falciparum. Promising new lead compounds undergoing development are described and an overview of physicochemical properties of chloroquine and amodiaquine analogues is also included.
Resistance to platelet microbicidal protein results in increased severity of experimental Candida albicans endocarditis (1996)

Thrombin-induced platelet microbicidal protein (tPMP) exerts potent in vitro microbicidal activity against pathogens commonly found in the bloodstream, including Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans. Localized platelet release of tPMP may be important in defense against infections involving the vascular endothelium caused by tPMP-susceptible organisms. In contrast, pathogens capable of surviving in the presence of tPMP could then exploit the platelet as an adhesive surface for attachment to damaged endothelium. To examine these hypotheses, we derived a tPMP-resistant (tPMP(r)) C. albicans strain from its tPMP-sensitive (tPMP(s)) parental strains were equivalent in vitro as assessed by genotyping (electrophoretic karyotype and restriction endonuclease analysis of genomic DNA), biotyping, germination, platelet aggregation, adherence to vascular endothelial cells, and growth characteristics. In addition, the tPMP(r) phenotype was stable following multiple in vitro and in vivo passages. We then investigated the in vivo relevance of tPMP susceptibility on endovascular infection using a rabbit model of endocarditis and hematogenous dissemination. Rabbits with transaortic catheters (n = 15 in each group) were challenged with either the tPMP(s) or tPMP(r) C. albicans strain. All rabbits developed C. albicans-induced endocarditis, as determined by the presence of infected vegetations. In rabbits challenged with tPMP(s) strain (P < 0.001). These results were seen in the absence of differences in either initial adherence of strains to cardiac valves or vegetation weights. Furthermore, although these C. albicans strains induced equivalent rates and extent of hematogenous renal infection, only the tPMP(r) strain disseminated hematogenously to the spleen (15 of 15 rabbits) versus 0 of 15 [tpmp(s) strain]; P < 0.0001). Thus, tPMP(r) C. albicans caused more-severe endocarditis and produced greater metastatic sequelae than the tPMP(s) counterpart.
Two-dimensional sampling-image x-ray streak camera for ultrafast imaging of inertial confinement fusion plasmas (1999)

Ultrafast two-dimensional (2D) x-ray imaging with a temporal resolution better than 10 ps is of great importance in diagnosing the final stages of the imploded core plasmas of inertial confinement fusion (ICF) targets. The multi-imaging x-ray streak camera (MIXS) has been one of such imaging techniques. Recently, we have proposed another scheme, a 2D sampling-image x-ray streak camera method (2D-SIXS). In this scheme, a 2D image is sampled two dimensionally with a set of sampling points distributed regularly over the whole image on a cathode plate of an x-ray streak camera. The sampled image is streaked, and then, reconstructed to form the time-resolved 2D images like movie pictures. In this article, we report results of our proof-of-principle experiments of 2D-SIXS scheme performed at Gekko-XII glass laser system. A gold-coated spherical target was irradiated by three beams (0.53 μm) of Gekko-XII laser. Streaked data of 2D-SIXS were obtained and a series of time-resolved 2D x-ray images were successfully reconstructed. 2D-SIXS is suitable for very fast, short-lived, and small x-ray sources such as a hot spark in the ICF plasma as well as short-pulse-laser-produced plasmas.
Primary Biliary Cirrhosis (2010)

This chapter contains sections titled: Introduction Diagnosis Natural history Surrogate markers of outcome Therapeutic trial design: assessment of credibility Randomized controlled trials of treatment for primary biliary cirrhosis The future for therapy in primary biliary cirrhosis References