gebhart/patrepeval huggingface dataset:
Polyelectrolytes in Solution and at Surfaces (2001)

This chapter deals with charged polymers (polyelectrolytes) in solution and at surfaces. The behavior of polyelectrolytes is markedly different from that of neutral polymers. In bulk solutions, i.e. disregarding the surface effect, there are two unique features to charged polymers: first, due to the presence of long-ranged electrostatic repulsion between charged monomers, the polymer conformations are much more extended, giving rise to a very small overlap concentration and high solution viscosity. Second, the presence of a large number of counter-ions increases the osmotic pressure of polyelectrolyte solutions, making such polymers water soluble as is of great importance to many applications. At surfaces, the same interplay between monomer-monomer repulsion and counter-ion degrees of freedom leads to a number of special properties. In particular, the adsorption behavior depends on both the concentration of polymers and added salt in the bulk. We first describe the adsorption behavior of single polyelectrolyte molecules, and discuss the necessary conditions to obtain an adsorbed layer and characterize its width. Depending on the stiffness of the polyelectrolyte, the layer can be flat and compressed or coiled and extended. We then proceed and discuss the adsorption of polyelectrolytes from semi-dilute solutions. Mean-field theory profiles of polyelectrolyte adsorption are calculated as function of surface charge density (or surface potential), the amount of salt in the system and the charge fraction on the chains. The phenomenon of charge inversion is reviewed and its relevance to the formation of multilayers is explained. The review ends with a short overview of the behavior of grafted polyelectrolytes.
Histopathologic Evaluation of Adipose Autografts in a Rabbit Ear Model (1990)

Injection of autologous adipose tissue removed via liposuction has been used clinically for facial contouring, the aging face, furrows, facial atrophy, acne scars, nasolabial folds, chin, and various other surgical defects. Survival rates for autografts of fat have been quoted anywhere from 30% to 80%. Our study uses a reproducible rabbit animal model for autotransplantation of adipose tissue and examines the histopathologic changes that occur to the graft over time. Autogenous subcutaneous fat was removed from a dorsal scapular donor site, treated to stimulate cannula damage as in liposuction, then reinjected at the base of the ear. Histologic examination of the grafts were made at 5, 10, 15, 20, 40, and 100 days after transplantation. Hematoxylin-eosin sections were graded on degree of fibrosis present (0 to 4+), viable fat (1 to 10), degree of inflammation (0 to 4+), and neovascularization (+ or -). Viability of fat decreased from 8.5 to 10 at 5 days to 2 viability at 40 days. Acute inflammation peaked at 10 days, followed by the chronic inflammatory response with macrophages and multinucleated giant cells scavenging the dying fat graft. Neovascularization began at 5 days, peaked at 10 days, and remained constant thereafter only at the edge of the graft. Microcysts appeared at 15 days and increased in number in proportion to the decrease in viable fat. In summary, the temporal histologic events are progressive fibrosis; decreased amount of viable fat; inflammation beginning with a neutrophilic response, later a macrophage and giant cell response; and neovascularization at the periphery of the graft insufficient to maintain graft viability.(ABSTRACT TRUNCATED AT 250 WORDS)
Reconfigurable architectures for VLSI processing arrays (1983)

Definition of architectures capable of fault tolerance and reconfiguration, suitable for very large scale integration (VLSI) implementation, is an important problem with regard to both production yield and run-time availability of VLSI devices. The case considered in the present paper concerns regular arrays of processing elements, such as the ones found in signal processing and other dedicated structures. It is proposed to achieve fault tolerance through the introduction of spare elements and reconfiguration algorithms implemented by suitable dedicated circuits and signals. A number of reconfigurable structures are presented, with different numbers and patterns of spare elements and with varying degrees of fault tolerance. Underlying fault assumptions are discussed and performances are analyzed; while architectures examined in detail consist of combinatorial elements with fairly simple interconnection schemes, extension to a wider class of structures is also considered. Implementation of diagnosis and reconfiguration is carried out at gate level: the resulting complexity is seen to be minor, as compared to the overall architecture complexity.
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis (2004)

Expression of glomerular and interstitial MMP-2, -3, -9 and TIMP-1 is increased in active ANCA-associated glomerulonephritis and correlates with inflammatory activity.
Intravenous injection of Candida-derived mannan results in elevated tumor necrosis factor alpha levels in serum (1996)

Intravenous injection of Candida albicans into mice produced elevated serum tumor necrosis factor alpha (TNF-alpha) levels. We hypothesized that immunostimulants released in vivo from C. albicans during fungal sepsis might contribute to the elevated levels of TNF-alpha in serum. We tested this hypothesis in mice with C. albicans mannan (CAM). Increased serum TNF-alpha levels were observed following intravenous and intraperitoneal injections of CAM. Injection of CAM into mice resulted in increased serum TNF-alpha concentrations that reached 1,200 pg/ml of blood, compared with 2,400 microg/ml of blood following injection of 10 microg of endotoxin. The response to CAM was concentration dependent, requiring a minimum dose of 20 microg of CAM per g of body weight. Sera from mice were tested 30, 60, 90, and 120 min after intravenous injections with CAM. TNF-alpha concentrations were minimal 30 and 120 min after intravenous injection and maximal 60 and 90 min after CAM injection. The relative distribution of CAM in vivo in decreasing order was determined to be as follows: blood > liver > lung > spleen, 90 min following injection of a single 5-mg dose of CAM. CAM was confirmed as the stimulating substance by utilizing anti-CAM antibodies in vivo to block the response. Rabbit anti-mannan antibodies administered by intraperitoneal injection 24 h before CAM injection significantly suppressed (P < 0.05) the accumulation of TNF-alpha in the sera. Dexamethasone administered to mice before intravenous injection of mannan significantly reduced (40 to 90% reduction; P < 0.05) the concentrations of TNF-alpha in the sera of treated mice. Thus, when in vivo CAM clearance mechanisms are exceeded, sufficient CAM may become available to stimulate TNF-alpha production, making CAM an important part of pathogenesis in Candida sepsis.
Region of interest analysis using an SPM toolbox (2002)

Most functional imaging studies use analyses that look for effects anywhere in the brain. The standard approach is to calculate a statistic relating the experimental effect of interest to the data for each brain voxel. This method the advantage that it can detect strong effects without apriori constraint on the area that activation will occur. Problems arise when we wish to ask the question whether a particular brain area been activated: if we know the shape and location of the expected activity, then voxel by voxel approaches have low power, because of the multiple comparisons across voxels. Whole brain analyses usually use image smoothing in order to increase signal to noise; however, the best smoothing filter will depend on the shape of the activation, which may well not be matched by a standard kernel such as a Gaussian. The most direct answer to the question has this area been activated is to use a region of interest analysis. Here we define a region, and perform the statistical test on the mean time course of the voxels within the region. The contribution of the voxels may be weighted using the expected shape of the activation. This approach two advantages. First, we increase power by avoiding the multiple comparison problem. Second, if we are correct about the shape and location of the region, the process of taking the mean is equivalent to using the best smoothing kernel to recover the signal. This method proved very powerful in analysing the activation in well defined regions. For example, Kanwisher et al have used screening tasks and voxel by voxel statistics to define regions of interest, and used these regions to investigate the nature of the original activation in further experiments of visual analysis of faces, scenes, objects and body parts. We have implemented a toolbox called MarsBar for region of interest analysis within the SPM99 software package (available for free download from http://www.mrc-cbu.cam.ac.uk/Imaging/marsbar.html). The user can define regions using activations from previous SPM analyses, binary or weighted images, or simple shapes (boxes or spheres). Regions can be combined using a full range of algebra to give new regions. Functions include overlap between regions (logical and) or combination (logical or). The software can then extract raw or filtered time courses from the region for futher analysis outside SPM. It can also use new or previous SPM analysis files to analyze the regional time course. t or F statistics for multiple regions can be computed, and the results plotted using the SPM graphical interface. We are currently working on estimation of percentage signal change for the region data. Region of interest analyses are likely to become more important as prior hypotheses about the location of activation become more specific. This may have many advantages in terms of statistical power and the ease of interpretation of neuroimaging data. We hope that this toolbox will make such analyses simpler to implement.
Three-Dimensional Structure of Favin: Saccharide Binding-Cyclic Permutation in Leguminous Lectins (1986)

The three-dimensional structure of favin, the glucose- and mannose-binding lectin of Vicia faba (vetch, broad bean), has been determined at a resolution of 2.8 angstroms by molecular replacement. The crystals contain specifically bound glucose and provide the first high-resolution view of specific saccharide binding in a leguminous lectin. The structure is similar to those of concanavalin A (Con A) and green pea lectin; differences from Con A show that minimal changes are needed to accommodate the cyclic permutation in amino acid sequence between the two molecules. The molecule is an ellipsoidal dimer dominated by extensive beta structures. Each protomer contains binding sites for two divalent metal ions (Mn2+ and Ca2+) and a specific saccharide. Glucose is bound by favin in a cleft in the molecular surface and has noncovalent contacts primarily with two peptide loops, one of which contains several metal ion ligands. The specific carbohydrate-binding site is similar to that of Con A in location and general peptide folding, despite several differences in specific amino acid residues.
Sulfation Preceding Deiodination of Iodothyronines in Rat Hepatocytes (1983)

In man and animals iodothyronines are metabolized by deiodination and conjugation with glucuronic acid or sulfate. Until now these processes have been regarded as independent reactions. However, in the present study a close interaction of these pathways was observed in the hepatic metabolism of 3,3'-diiodothyronine and 3,3',5-triiodothyronine. Studies with rat hepatocytes and liver microsomes indicated that sulfation of the phenolic hydroxyl group facilitates the deiodination of these compounds.
A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670. (1994)

The observation that levels of the mitogenic peptide endothelin-1 are elevated in the human coronary sinus after percutaneous transluminal coronary angioplasty (PTCA) has implicated endothelin-1 in the etiology of vascular restenosis. The present study examined this hypothesis in both an in vitro and an in vivo rat model of neointimal formation by using the novel nonpeptide endothelin receptor antagonist SB 209670. In vitro, endothelin-1 (1 nmol/L) induced a ninefold increase in rat aortic vascular smooth muscle [3H]thymidine incorporation. This endothelin A receptor-mediated effect was completely inhibited by SB 209670 (IC50, 6.2 +/- 2.2 nmol/L). In vivo, acute intra-arterial administration of exogenous endothelin-1 (5 to 500 pmol/kg over a 30-minute period immediately after angioplasty) dose-dependently augmented the degree of neointimal formation (by up to 150% when assessed 14 days after surgery). This response was evident as early as 7 days after angioplasty. Hemodynamic studies indicated that this action was unrelated to a systemic pressor action of the peptide. Administration of SB 209670 (2.5 mg/kg IP, twice a day for 3 days before and for 2 weeks after surgery) reduced neointimal formation by approximately 50% relative to control animals. Thus, the data indicate for the first time that (1) endothelin-1 promotes neointimal formation in vivo and (2) endogenous endothelin-1 is involved in the pathogenesis of angioplasty-induced lesion formation in the rat. Endothelin receptor antagonists such as SB 209670 may therefore serve as useful adjuncts to PTCA, attenuating the degree of vascular restenosis observed after vascular wall injury.
Reflex regulation of airway smooth muscle tone (2006)

Autonomic nerves in most mammalian species mediate both contractions and relaxations of airway smooth muscle. Cholinergic-parasympathetic nerves mediate contractions, whereas adrenergic-sympathetic and/or noncholinergic parasympathetic nerves mediate relaxations. Sympathetic-adrenergic innervation of human airway smooth muscle is sparse or nonexistent based on histological analyses and plays little or no role in regulating airway caliber. Rather, in humans and in many other species, postganglionic noncholinergic parasympathetic nerves provide the only relaxant innervation of airway smooth muscle. These noncholinergic nerves are anatomically and physiologically distinct from the postganglionic cholinergic parasympathetic nerves and differentially regulated by reflexes. Although bronchopulmonary vagal afferent nerves provide the primary afferent input regulating airway autonomic nerve activity, extrapulmonary afferent nerves, both vagal and nonvagal, can also reflexively regulate autonomic tone in airway smooth muscle. Reflexes result in either an enhanced activity in one or more of the autonomic efferent pathways, or a withdrawal of baseline cholinergic tone. These parallel excitatory and inhibitory afferent and efferent pathways add complexity to autonomic control of airway caliber. Dysfunction or dysregulation of these afferent and efferent nerves likely contributes to the pathogenesis of obstructive airways diseases and may account for the pulmonary symptoms associated with extrapulmonary disorders, including gastroesophageal reflux disease, cardiovascular disease, and rhinosinusitis.
An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia (2004)

Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications and elevated serum phosphate levels. Recently, mutations in the GALNT3 gene have been described to cause FTC. The FTC phenotype is regarded as the metabolic mirror image of hypophosphatemic conditions, where causal mutations are known in genes FGF23 or PHEX. We investigated an individual with FTC who was negative for GALNT3 mutations. Sequencing revealed a homozygous missense mutation in the FGF23 gene (p.S71G) at an amino acid position which is conserved from fish to man. Wild-type FGF23 is secreted as intact protein and processed N-terminal and C-terminal fragments. Expression of the mutated protein in HEK293 cells showed that only the C-terminal fragment is secreted, whereas the intact protein is retained in the Golgi complex. In addition, determination of circulating FGF23 in the affected individual showed a marked increase in the C-terminal fragment. These results suggest that the FGF23 function is decreased by absent or extremely reduced secretion of intact FGF23. We conclude that FGF23 mutations in hypophosphatemic rickets and FTC have opposite effects on phosphate homeostasis.
Chromosome 17 and hereditary dementia (1997)

Several previous families with differing clinical and pathologic characteristics have demonstrated linkage to the 17q21-22 region. We have performed a linkage analysis with chromosome 17 markers on three families showing autosomal dominant inheritance of non-Alzheimer dementia and 60 kindreds with late-onset familial Alzheimer's disease (FAD). Family A shows unequivocal evidence of linkage with a maximum lod score of 5.0 for marker D17S934 (theta = 0.001). This family has an unusual syndrome of a schizophrenia-like psychosis beginning in the fifth or sixth decade followed by severe dementia with an average disease duration of 13.8 years. Neuropathology from five autopsies in this family has shown marked neurofibrillary tangle formation (NFT), degeneration of the amygdala, and no amyloid plaques. This confirms the presence of a gene associated with dementia on 17q and extends the related phenotype to include schizophrenia-like symptoms and classic NFT pathology. A second family with early aphasia progressing to dementia and cortical-basal ganglion-like degeneration also has suggestive evidence for linkage to 17q. A third family with very early-onset dementia (mean, 31 years) and nonspecific pathology can be excluded from the 17q region and emphasizes additional genetic heterogeneity in non-Alzheimer hereditary dementia. Finally, we also present evidence against linkage to D17S579 in the set of 60 families with late-onset FAD, providing further evidence that the chromosome 17 gene is unlikely to be involved in the pathogenesis of typical AD.
Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification (1988)

The application of recombinant DNA technology to prenatal diagnosis of many recessively inherited X-linked diseases is complicated by a high frequency of heterogeneous, new mutations (1). Partial gene deletions account for more than 50% of Duchenne muscular dystrophy (DMD) lesions, and approximately one-third of all cases result from a new mutation (2-5). We report the isolation and DNA sequence of several deletion prone exons from the human DMD gene. We also describe a rapid method capable of detecting the majority of deletions in the DMD gene. This procedure utilizes simultaneous genomic DNA amplification of multiple widely separated sequences and should permit deletion scanning at any hemizygous locus. We demonstrate the application of this multiplex reaction for prenatal and postnatal diagnosis of DMD.
Relationship betweenSeismocardiogram andEchocardiogram for Events inthe Cardiac Cycle (1994)

Seismocardiography (SCG) is a noninvasive method to record ultralow-frequency cardiac vibrations from the chest wall using an accelerometer. This research evaluated the relationship between SCG and echocardiography (Echo); 39 subjects had simultaneous SCG and Echo, 28 were normals and 11 had dilated cardiomyopathy. Ten SCG points were compared with their corresponding systolic and diastolic Echo points. The mean absolute difference between SCG and Echo for 5 systolic points was 7.6 ms and 6.8 ms for the 5 diastolic points. Two SCG systolic points showed increased divergence from the Echo points in subjects with cardiomyopathy. Both methods showed approximately equal ability to distinguish longer cardiac time intervals among abnormals compared with normals. Intrasubject variability was lower in the SCG than Echo. The consistency between SCG and Echo points indicates that they are equally accurate in measuring cardiac time intervals.
Testosterone therapy in the aging male (2007)

The decline, with aging, in serum concentrations of biologically active forms of testosterone in men is an indisputable fact and some men will eventually develop symptoms of late-onset hypogonadism (LOH) with its clinical consequences. LOH reduces quality of life and may pose important risk factors for frailty, changes in body composition, cardiovascular disease, sexual dysfunction and osteoporosis. Testosterone supplementation in cases of LOH will restore serum testosterone levels into the physiologic range; will restore metabolic parameters to the eugonadal state, increase muscle mass, strength, and function; maintaine or improve BMD reducing fracture risk; will improve neuropsychological function (cognition and mood); libido and sexual functioning; and enhance quality of life. The ultimate goals, however, are to maintain or regain a high quality of life, to reduce disability, to compress major illnesses into a narrow age range and to add life to years. To achieve these goals men must also adjust their lifestyle to optimize dietary habits, as well as to exercise and to abstain from smoking life-long. Monitoring these patients is a shared responsibility that cannot be taken lightly. The physician must emphasize to the patient the need for periodic evaluations and the patient must agree to comply with these requirements. The physician's evaluation should include an assessment of the clinical response and monitoring must be tailored to the indications and individual needs of the patient.
Best Practices for Scientific Research on Neural Architecture Search (2019)

Finding a well-performing architecture is often tedious for both DL practitioners and researchers, leading to tremendous interest in the automation of this task by means of neural architecture search (NAS). Although the community has made major strides in developing better NAS methods, the quality of scientific empirical evaluations in the young field of NAS is still lacking behind that of other areas of machine learning. To address this issue, we describe a set of possible issues and ways to avoid them, leading to the NAS best practices checklist available at http://automl.org/nas_checklist.pdf.