gebhart/patrepeval huggingface dataset:
3D Imaging Of The Human Eye Using The Laser Tomographic Scanner Lts (1987)

The Laser Tomographic Scanner LTS is an instrument for contact-free measurement of curvature, thick-ness and incision profiles of the human cornea and of topographic features of the human retina. A line-shaped laser beam is focused onto the eye via special optics. The intensity of the reflected light is detected only if it originates from a very small region around the focal plane of the special optics. Consequently, images with high spatial resolution in all directions are obtained. The line-shaped beam is imaged on the eye with arbitrary direction of the line. At the same time, the focal plane of the special optics is moved periodically. This results in real-time section images of the cornea as well as the retina perpendicular to its surface. System functions are computer-controlled. The instrument is equipped with a powerful computer image processor which produces operator-independent results with high accuracy within seconds.
In vitro potency of inhibition by antiviral drugs of hematopoietic progenitor colony formation correlates with exposure at hemotoxic levels in human immunodeficiency virus-positive humans (1996)

Inhibition of in vitro colony formation of human hematopoietic progenitors (CFU-granulocyte-macrophage, burst-forming unit-erythroid) by the antiviral nucleoside drugs alovudine, zalcitabine, zidovudine, ganciclovir, stavudine, didanosine, lamivudine, and acyclovir was measured. Significant correlations between in vitro 50% inhibitory concentrations and the daily human exposures (area under the concentration-time curve from 0 to 24 h; in micromolar.hour) of these chronically administered drugs in human immunodeficiency virus-positive patients that induced neutropenia or anemia were demonstrated by both linear regression and Spearman rank-order analyses. These quantitative correlations allow estimation of the exposure at which bone marrow toxicity may occur with candidate compounds.
<title>CT artifact correction: an image-processing approach</title> (1996)

This paper presents an image processing approach for correcting streaking artifacts in computed tomography (CT) images and compares it to physics based and composite approaches. In CT, there are two major sources for streaking artifacts: beam hardening and nonlinear partial volume averaging. The physics based approach uses a physical model for the beam hardening. Inaccuracy of the model and nonlinear partial volume averaging result in an incomplete correction of the artifacts by this approach. The proposed image processing approach identifies and corrects the artifacts using their frequency characteristics. It corrects the artifacts regardless of their source. The composite approach also utilizes the physical model for the beam hardening. Although correcting some of the artifacts, it is computationally more intense than the image processing approach. We illustrate the methods and compare their performance using a computer simulation and CT images of a phantom and a human brain. We show that the streaking artifacts resulting from nonlinear partial volume averaging which are not corrected by the physics based method are corrected by the image processing approach.
Microvessel Density as a Prognostic Factor in Women with Breast Cancer (2004)

We performed a meta-analysis of all 87 published studies linking intratumoral microvessel density (MVD), reflecting angiogenesis, to relapse-free survival (RFS) and overall survival (OS). With median MVD as cutoff, MVD impact was measured by risk ratio (RR) between the two survival distributions. Seventeen studies did not mention survival data or fit inclusion criteria. Twenty-two were multiple publications of the same series, leaving 43 independent studies (8936 patients). MVD was assessed by immunohistochemistry, using antibodies against factor VIII (27 studies; n = 5262), CD31 (10 studies; n = 2296), or CD34 (8 studies; n = 1726). MVD might be a better prognostic factor when assessed by CD31 or CD34 versus factor VIII (P = 0.11). For RFS, statistical calculations were performed in 25 studies (6501 patients). High MVD significantly predicted poor survival [RR = 1.54 for RFS and OS with the same 95% confidence interval (CI), 1.29-1.84]. Twenty-two studies analyzed separately lymph node-negative patients (n = 3580), for whom predictors of poor survival are requested. This latter meta-analysis included 15 studies for RFS (2727 patients) and 11 for OS (1926 patients). High MVD significantly predicted poor survival [RR = 1.99 for RFS (95% CI, 1.33-2.98) and RR = 1.54 for OS (95% CI, 1.01-2.33)]. Between-study variations could result from patient selection criteria, techniques to stain and count microvessels, and cutoff selection. MVD was a significant although weak prognostic factor in women with breast cancer. Standardization of MVD assessment is needed.
New England's Blue Cross Blue Shield shake-out: a case study in consumer activism. (1999)

For two generations, Blue Cross Blue Shield (BCBS) insurance plans could be counted on to play a key role in the financing of every community's health care system. "The Blues" dominated the health insurance market, yet they were also a reliable "insurer of last resort." In recent years, BCBS plans have begun to re-structure to stay competitive. Four of New England's BCBS plans have proposed or completed mergers with Anthem Insurance, a mutual insurance company based in Indiana. This issue of States of Health looks at how advocates in New England are working together to protect health care consumers amid this transformation.
Structural Similarities and Functional Differences (1995)

Our understanding of the role in intermediary metabolism of the gene superfamily of proteins called P450 has changed with the cloning and sequencing of greater than 300 genes that encode unique forms of this protein.! While P450s have been thought of as being primarily located in the liver and endocrine organs of mammals where they catalyze the detoxification of drugs and the synthesis of steroid hormones,2 P450s are found in essentially all mammalian tissues including brain,3 skin,4 and intestine.5 Additionally, with the continued identification of unique P450s, which catalyze biosynthetic and biodegradative reactions in mammals as well as in plants, fungi, and bacteria, it has been realized that the role of P450s is much more diverse than had been previously suspected. (For example, the role ofP450s in phytoalexin,6 anthocyanidin,7 isoflavanoid,8 andjasmonic acid9 synthesis in plants is well documented.) Thus, scientists have become interested in the mechanisms of disease states resulting from mutations in P450s, and in alternative substrates metabolized and new products formed by the engineering of known P450 proteins. Only through an understanding of the structures of these proteins can this be accomplished. As shown in Eq. (1), the fundamental reaction that P450s catalyze is monooxygenation or mixed function oxidation; however, these enzymes also catalyze sulfur oxidation, epoxidation, cleavage of carbon-carbon bonds, alkyl group migration, and aromatization to name but a few different types of reactions.!O
Staphylococcus epidermidis Causing Prosthetic Valve Endocarditis: Microbiologic and Clinical Observations as Guides to Therapy (1983)

Seventy-five episodes of prosthetic valve endocarditis from Staphylococcus epidermidis were studied retrospectively. Methicillin-resistant isolates caused 53 (87%) of 61 infections occurring within 1 year of surgery but only two of the nine after 1 year (p < 0.001). Resistance to methicillin was heterogeneic and extended to the cephalosporins. Of 55 isolates, 43 (78%) were susceptible to gentamicin and all to vancomycin and rifampin. In 55 patients, prosthetic valve endocarditis was complicated by tissue invasion or valve dysfunction. Among these 55 patients, 30 of the 32 who were cured needed surgery. Prosthetic valve endocarditis from methicillin-resistant S. epidermidis was cured in 21 of 26 patients treated with vancomycin and 10 of 20 treated with beta-lactam antibiotic therapy (p = 0.055). Cure rates of patients treated with vancomycin but not betalactam antibiotics were increased by the addition of rifampin or gentamicin to therapy. Prosthetic valve endocarditis from methicillin-resistant S. epidermidis should be treated with vancomycin plus rifampin, or an aminoglycoside. Surgical intervention is important in treating complications of prosthetic valve endocarditis.
A colorimetric bead‐binding assay for detection of intermolecular interactions (2002)

We have developed a new technique that rapidly and reproducibly allows direct visualization of molecular interactions, including receptor-ligand binding. The technique can be easily applied to examine binding between proteins and glycoproteins, or proteins and glycolipids, including gangliosides. In this novel bead-binding assay, the suspected 'ligand' molecule is bound to 0.2- or 1.0- micro m colored FluoSphere beads. These coated beads are then mixed directly with 150- micro m Sepharose or 50- to 75- micro m agarose beads coated with the second 'target' molecule. Binding between molecules is easily detected by immunofluoresence microscopy as colored rosettes or aggregations formed by clustering of the smaller fluorescent beads around the larger non-fluorescent bead. The validity of this technique for glycolipid binding to protein was verified through demonstration of the known interaction between the beta subunit of cholera toxin with ganglioside GM1. The bead-binding technique facilitated the novel observations of interaction between ganglioside GT1b with the alpha5 subunit of alpha5beta1 integrin and the interaction of GM3 with the epidermal growth factor receptor. A modification of this technique, in which the coated beads are bound to protein fixed on plates, allows a quantifiable colorimetric assay of interaction. This versatile and rapid technique will have widespread applications for in vitro systems and may also be useful for in vivo analysis of binding to cell surface receptor molecules.
Factors influencing the specific interaction of Neisseria gonorrhoeae with transforming DNA (1991)

The specific interaction of transformable Neisseria gonorrhoeae with DNA depends on the recognition of specific 10-residue target sequences. The relative affinity for DNA between 3 and 17 kb in size appears to be linearly related to the frequency of targets on the segment and is unaffected by absolute size. The average frequency of targets in chromosomal DNA of N. gonorrhoeae appears to be approximately one per 1,000 bp.
Kappa‐opioid receptor agonists increase locomotor activity in the monoamine‐depleted rat model of parkinsonism (1998)

Excessive glutamate transmission in the basal ganglia is a major factor in the neural mechanisms underlying parkinsonian akinesia. Activation of kappa opioid receptors causes a presynaptic reduction in glutamate release. Kappa opioid receptors are concentrated in those regions of the basal ganglia associated with increased glutamate transmission in parkinsonism. In this study, we use the alpha-methyl-p-tyrosine and reserpine-treated rat model of parkinsonism to investigate whether systemic administration of the kappa opioid agonists enadoline (CI-977) and U69,593 can alleviate the symptoms of parkinsonism either alone or in conjunction with dopamine replacement therapy. We report that, when administered alone, both enadoline and U69,593 can increase locomotion in monoamine-depleted rats. No increase in locomotor activity was seen after kappa opioid agonist administration in non-parkinsonian rats. The responses to kappa opioid agonists were blocked by co-administration of either the nonspecific opioid receptor antagonist naloxone or the selective kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI). An important finding is that when enadoline and L-dopa are administered together, their anti-akinetic properties are synergistic. Thus, the doses of enadoline and L-dopa required to alleviate akinesia when administered together are lower than either administered alone. These data illustrate the importance of kappa opioid receptors in the neural mechanisms controlling voluntary movement and suggest that kappa opioid agonists may have a role as adjuncts to dopamine replacement in the management of Parkinson's disease.
Catalytic Cleavage of the C-H and C-C Bonds of Alkanes by Surface Organometallic Chemistry: An EXAFS and IR Characterization of a Zr-H Catalyst (1996)

The catalytic cleavage under hydrogen of the C-H and C-C bonds of alkanes with conventional catalysts requires high temperatures. Room-temperature hydrogenolysis of simple alkanes is possible on a well-defined and well-characterized zirconium hydride supported on silica obtained by surface organometallic chemistry. The surface structure resulting from hydrogenolysis of (≡SiO)Zr(Np) 3 (Np, neopentyl) was determined from the extended x-ray absorption fine structure (EXAFS) and 1 H and 29 Si solid-state nuclear magnetic resonance and infrared (IR) spectra. A mechanism for the formation of (≡SiO) 3 Zr-H and (≡SiO) 2 SiH 2 and the resulting low-temperature hydrogenolysis of alkanes is proposed. The mechanism may have implications for the catalytic formation of methane, ethane, and lower alkanes in natural gas.
On the Peak Factor of Sampled and Continuous Signals (2006)

The peak factor of a continuous digitally- modulated signal is often analyzed from its samples taken at the Nyquist rate. This, however, may involve a significant error. It has been claimed, based on an illustrative example, that the peak factor of a continuous signal may be arbitrary large while the peak factor of the corresponding sampled signal is limited [Wulich, D., 2000]. A validity of this example has been questioned in [Ermolova, N., 2001; Minn, E., et al., 2001] based on a flaw in [Wulich, D., 2000]. In this paper, we demonstrate that the original illustrative example requires a small modification only to remove the flaw. It is also demonstrated that the continuous peak factor, in its traditional definition, may be arbitrary large while the sampled peak factor and the signal energy are bounded. An upper bound on the continuous peak factor of a BPSK sequence is derived.
The GRASP Multiple Micro-UAV Testbed (2010)

In the last five years, advances in materials, electronics, sensors, and batteries have fueled a growth in the development of microunmanned aerial vehicles (MAVs) that are between 0.1 and 0.5 m in length and 0.1-0.5 kg in mass [1]. A few groups have built and analyzed MAVs in the 10-cm range [2], [3]. One of the smallest MAV is the Picoftyer with a 60-mmpropellor diameter and a mass of 3.3 g [4]. Platforms in the 50-cm range are more prevalent with several groups having built and flown systems of this size [5]-[7]. In fact, there are severalcommercially available radiocontrolled (PvC) helicopters and research-grade helicopters in this size range [8].
Oncolytic Vaccinia Virus Therapy of Salivary Gland Carcinoma (2013)

These promising results demonstrate significant oncolytic activity by an attenuated vaccinia virus for infecting and lysing salivary gland carcinomas, supporting future clinical trials.
The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in mice (2013)

Iron transport has been linked to the virulence of Brucella strains in both natural and experimental hosts. The genes designated BAB2_0837-0840 in the Brucella abortus 2308 genome sequence are predicted to encode a CupII-type ferrous iron transporter homologous to the FtrABCD transporter recently described in Bordetella. To study the role of the Brucella FtrABCD in iron transport, an isogenic ftrA mutant was constructed from B. abortus 2308. Compared with the parental strain, the B. abortus ftrA mutant displays a decreased capacity to use non-haem iron sources in vitro, a growth defect in a low iron medium that is enhanced at pH 6, and studies employing radiolabelled FeCl3 confirmed that FtrABCD transports ferrous iron. Transcription of the ftrA gene is induced in B. abortus 2308 in response to iron deprivation and exposure to acid pH, and similar to other Brucella iron acquisition genes that have been examined the iron-responsiveness of ftrA is dependent upon the iron response regulator Irr. The B. abortus ftrA mutant exhibits significant attenuation in both cultured murine macrophages and experimentally infected mice, supporting the proposition that ferrous iron is a critical iron source for these bacteria in the mammalian host.
Repair of heteroduplex DNA molecules with multibase loops in Escherichia coli (1993)

The fate of heteroduplex molecules containing 5-, 7-, 9-, 192-, 410-, and 514-base loops after transformation of wild-type and various mutant strains of Escherichia coli has been examined. No evidence for repair was obtained for the wild type or for strains with mutations in the following genes: mutS, recA, recBC sbcBC, recD, recF, recJ, recN, recO, recR, recBC sbcBC recF uvrA, recG ruvC, ruvB, lexA3, lexA51, uvrA, nfo xth nth, polA(Ts), or pcnB. These results rule out the involvement of the SOS system and most known recombination and repair pathways. Repair of heteroduplex molecules containing 410- and 514-base loops was observed when a 1-base deletion-insertion mismatch was present nearby. The repair of both the mismatch and the loops was directed by the state of dam methylation of the DNA chains and was dependent on the product of the mutS gene. A high efficiency of repair (95%) was found even when the mismatch and the loops were 1,448 nucleotides apart. We conclude that multibase loops in DNA can be removed only as a consequence of corepair by dam-directed mismatch repair.
A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development (2002)

The human MATER and mouse Mater genes and proteins are conserved. Characterization of the human MATER and its protein provides a basis for investigating their clinical implications in autoimmune premature ovarian failure and infertility in women.
Osmotic control of kdp operon expression in Escherichia coli. (1981)

Turgor pressure, the difference in osmotic pressure across the inner membrane, has been found to regulate expression of the kdp operon in Escherichia coli. The kdp operon codes for a high-affinity repressible transport system for the uptake of potassium. We have studied the regulation of Kdp expression in a strain in which the gene for beta-galactosidase, lacZ, was placed under control of the kdp promotor. Neither internal nor external K+ concentrations directly controlled Kdp expression. Only when the external K+ concentration was reduced to the point of limiting growth was the kdp operon expressed. An increase in external osmolarity at constant K+ concentration, a procedure that reduces turgor pressure, caused expression of the kdp operon. As the magnitude of the osmotic shift was increased, corresponding to greater decreases in turgor pressure, the amount of Kdp expression also increased. The kdp operon thus appears to be controlled by changes in a physical force, the turgor pressure.
Purine sensing by riboswitches (2007)

Structured mRNA elements called riboswitches control gene expression by binding to small metabolites. Over a dozen riboswitch classes have been characterized that target a broad range of molecules and vary widely in size and secondary structure. Four of the known riboswitch classes recognize purines or modified purines. Three of these classes are closely related in conserved sequence and secondary structure, but members of these classes selectively recognize guanine, adenine or 2'-deoxyguanosine. Members of the fourth riboswitch class adopt a distinct structure to form a selective binding pocket for the guanine analogue preQ(1) (7-aminomethyl-7-deazaguanine). All four classes of purine-sensing riboswitches are most likely to recognize their respective metabolites by utilizing a riboswitch residue to make a canonical Watson-Crick base-pair with the ligand. This review will provide a summary of the purine-sensing riboswitches, as well as discuss the complex functions and applications of these RNAs.
Animal Cell Cycles and Their Control (1992)

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
Adsorptive Plasma Treatment: Optimization of Extracorporeal Devices and Systems (1993)

Devices in current use for adsorptive plasma treatment have, in many cases, been adapted from other types of separation processes. Minimizing system volume and quantity of ligand per mass transferred are proposed as appropriate design goals for an adsorptive plasma treatment system. The process consists of two operations: cell/plasma separation and solute adsorption/desorption. An example of an optimally designed membrane cell separator is presented which adds a negligibly small volume to the system. By overcoming mass transfer limitations, both volume and ligand quantity associated with the sorbent device can be minimized. Combining both of the above operations in a single device is also feasible. Examples are discussed of optimally designed sorbent devices and devices which combine cell separation/solute adsorption.
Thelet-7microRNA reduces tumor growth in mouse models of lung cancer (2008)

MicroRNAs have been increasingly implicated in human cancer and interest has grown about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent form of cancer worldwide and lacks effective therapies. Here we have used both in vitro and in vivo approaches to show that the let-7 microRNA directly represses cancer growth in the lung. We find that let-7 inhibits the growth of multiple human lung cancer cell lines in culture, as well as the growth of lung cancer cell xenografts in immunodeficient mice. Using an established orthotopic mouse lung cancer model, we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene. These findings provide direct evidence that let-7 acts as a tumor suppressor gene in the lung and indicate that this miRNA may be useful as a novel therapeutic agent in lung cancer.
Skill Acquisition and Firm Creation in Transition Economies (1999)

The transition from plan to market has hinged on the development of a dynamic private sector that would serve as the engine of growth and employment creation. This paper examines the link between the availability of skilled workers and the creation of new private firms. Using a dynamic search model, it shows how the lack of skilled workers inhibits entrepreneurship and depresses the rate of firm creation, slowing the recovery of aggregate output and labor productivity during the transition. The paper also shows how policies designed to encourage skill acquisition by workers have a positive impact on the economy.