gebhart/patrepeval huggingface dataset:
Topiramate in Refractory Epilepsy: A Prospective Observational Study (2000)

TPM was efficacious as add-on and monotherapy in patients with refractory partial and generalized seizures in everyday clinical use. A good response was obtained in many patients with TPM doses substantially lower than those studied in regulatory clinical trials. The wide variation in dose-response and dose-toxicity relationships may reflect different neurobiologies causing refractory epilepsy and differential efficacy of AED combinations.
Nutrition and Immunity with Emphasis on Infection and Autoimmune Disease (1996)

Nutrition and nutritional status can have profound effects on immune functions, resistance to infection and autoimmunity in man and other animals. Nutrients enhance or depress immune function depending on the nutrient and level of its intake. Protein-energy malnutrition and vitamin A deficiency are strongly associated with impaired immunity and infectious disease. The essential role vitamin A plays in infection and maintenance of mucosal surfaces has long been known. Recent evidence shows that T-cell subpopulations, cytokines and antibody subclasses are all affected by vitamin A. In animal studies supplementation with vitamin E protects against infection and is linked to stimulatory effects on the immune system. In man vitamin E and other anti-oxidants increase the number of CD4+ cells. Dietary lipids and zinc have a substantial impact on autoimmunity from protective to potentiation of immuno-pathological processes in animals. There is considerable potential to modify human autoimmune disease by manipulation of lipid nutrition. Deficiency of pyridoxine induces atrophy of lymphoid organs, marked reduction in lymphocyte numbers, impairs antibody responses and IL-2 production. Dietary copper is important in the prevention of infection in some animal species and T-cell function is defective under deficiency states due to an inability to produce IL-2. Selenium has been linked to viral infection, enhanced T-cell functions and TNF beta induced increase in natural killer cell activity. Understanding the molecular and cellular immunological mechanisms involved in nutrient-immune interactions will increase our applications for nutrition of the immune system in health and in disease
Polymerization of phenols catalyzed by peroxidase in nonaqueous media (1987)

Polymers produced by horseradish-peroxidase-catalyzed coupling of phenols have been explored as potential substitutes for phenol-formaldehyde resins. To overcome low substrate solubilities and product molecular weights in water, enzymatic polymerizations in aqueous-organic mixtures have been examined. Peroxidase vigorously polymerizes a number of phenols in mixtures of water with water-miscible solvents such as dioxane, acetone, di-methylformamide, and methyl formate with the solvent content up to 95%. As a result, various phenolic polymers with average molecular weights from 400 to 2.6 x 10(4) D were obtained depending on the reaction medium composition and the nature of the phenol. Peroxidase-catalyzed copolymerization of different phenols in 85% dioxane was demonstrated. Poly(p-phenylphenol) and poly(p-cresol) were enzymatically prepared on a gram scale. They had much higher melting points, and in addition, poly(p-phenylphenol) was found to have a much higher electrical conductivity than phenol-formaldehyde resins.
Amorphous Oxide Semiconductors for High-Performance Flexible Thin-Film Transistors (2006)

Recently, we have demonstrated the potential of amorphous oxide semiconductors (AOSs) for developing flexible thin-film transistors (TFTs). A material exploration of AOSs desired as the channel layer in TFTs is most important for developing high-performance devices. Here, we report our concept of material exploration for AOSs in high-performance flexible and transparent TFTs from the viewpoints of chemical bonding and electronic structure in oxide semiconductors. We find that amorphous In–Ga–Zn–O (a-IGZO) exhibits good carrier transport properties such as reasonably high Hall mobilities (>10 cm2·V-1·s-1) and a good controllability of carrier concentration from <1015 to 1020 cm-3. In addition, a-IGZO films have better chemical stabilities in ambient atmosphere and at temperatures up to 500 °C. The flexible and transparent TFT fabricated using a-IGZO channel layer at room temperature operated with excellent performances, such as normally-off characteristics, on/off current ratios (∼106) and field-effect mobilities (∼10 cm2·V-1·s-1), which are higher by an order of magnitude than those of amorphous Si:H and organics TFTs.
Efficient Super-Resolution Method for Single Image based on Deep Neural Networks (2018)

단일 영상 초해상도 복원은 하나의 저해상도 영상에서 고해상도 영상을 복원하는 과정이다. 최근 깊은 인공 신경망 기술이 발전함에 따라 단일 영상 초해상도 복원에서도 깊은 인공 신경망 기술이 성과를 나타냈다. 본 논문은 단일 영상 초해상도 복원을 위해 깊은 인공 신경망 기술을 효율적으로 적용하는 방법에 대해 연구하였으며, 네트워크 내부 확대 기법, L1 손실 함수의 사용, 잔차 학습 구조를 통해 기존 기법보다 효율적으로 영상 복원하는 기법을 제안한다. 제안하는 방법은 기존 방법보다 화질은 PSNR기준으로 0.57㏈ 만큼 우수하며 속도는 1.48배 빠른 것을 실험을 통해 확인하였다.
Synthesis and Antinociceptive Activity of Some 3-Chlorophenyl- and 6-Chloropyridin-2-yl Derivatives (1999)

Derivatives of 2-chloro-6-(4-hydroxy-1-methylpiperidin-4-yl)pyridine ( 2b ) were prepared and tested as analgesics. 2-Chloro-6-lithiopyridine treated with quinuclidin-3-one, 1-methylpyrrolidin-3-one, 2-(dimethylaminomethyl)cyclohexanone, and ethyl 1-methylpiperidin-4-ylcarboxylate provided the corresponding alcohols 5 , 6 , 13a , and 6-chloro-2-pyridyl 1-methylpiperidin-4-yl ketone ( 9 ). The ketone was reduced with sodium borohydride or treated with methylmagnesium chloride or phenyllithium to provide the corresponding alcohols 11 , 12a and 12b , respectively. 1-[4-(6-Chloro-2-pyridyl)1-methylpiperidin-4-yl]-1-methylethanol ( 4b ) was prepared from 2-chloro-6-(1-methyl-1,2,5,6-tetrahydropyridin-4-yl)pyridine ( 14b ) by treatment with butyllithium and acetone followed by reduction of intermediate 15b with sodium cyanoborohydride.
A subspace based blind and semi-blind channel identification method for OFDM systems (2003)

A new subspace method performing the blind and semi-blind identification of the transmission channel suited to multicarrier systems with cyclic prefix (OFDM) is proposed in this paper. This technique has the advantage to preserve the classical OFDM emitter structure based on a cyclic prefix insertion. Therefore it applies to all existing standardized multicarrier systems (DAB, ADSL, etc.) and does not prevent the use of the classical very simple equalization scheme. Moreover the method detailed provides an unbiased channel estimation and is robust to channel order overdetermination provided that the channel frequency response has no zeroes located on a subcarrier.
Concise review: Mesenchymal stem cell treatment for ischemic kidney disease (2013)

Ischemic kidney diseases are common clinical entities that bear high mortality and morbidity and may lead to irreversible loss of kidney function. Their pathophysiology is multifaceted, involves complex hormonal-immunological-cellular interactions, and leads to damage in multiple cell types, which is often resistant to conventional therapy. Thus, novel strategies are needed to repair the renal parenchyma and preserve kidney function. Mesenchymal stem cells (MSC) confer renal protection through paracrine/endocrine effects and to some degree possibly by direct engraftment. Their anti-inflammatory and immune-modulatory properties target multiple cascades in the mechanisms of ischemic kidney disease. This review focuses on recent progress on the use of MSC to prevent kidney injury in ischemic kidney injury, with a focus on the chronic form.
Connecting extracellular metabolomic measurements to intracellular flux states in yeast (2009)

Our results indicate that integrating quantitative extracellular metabolomic profiles in a constraint-based framework enables inferring changes in intracellular metabolic flux states. Similar methods could potentially be applied towards analyzing biofluid metabolome variations related to human physiological and disease states.
Encapsulation of Organic Molecules in Calcium Phosphate Nanocomposite Particles for Intracellular Imaging and Drug Delivery (2008)

Encapsulation of imaging agents and drugs in calcium phosphate nanoparticles (CPNPs) has potential as a nontoxic, bioresorbable vehicle for drug delivery to cells and tumors. The objectives of this study were to develop a calcium phosphate nanoparticle encapsulation system for organic dyes and therapeutic drugs so that advanced fluoresence methods could be used to assess the efficiency of drug delivery and possible mechanisms of nanoparticle bioabsorption. Highly concentrated CPNPs encapsulating a variety of organic fluorophores were successfully synthesized. Well-dispersed CPNPs encapsulating Cy3 amidite exhibited nearly a 5-fold increase in fluorescence quantum yield when compared to the free dye in PBS. FCS diffusion data and cell staining were used to show pH-dependent dissolution of the particles and cellular uptake, respectively. Furthermore, an experimental hydrophobic cell growth inhibitor, ceramide, was successfully delivered in vitro to human vascular smooth muscle cells via encapsulation in CPNPs. These studies demonstrate that CPNPs are effective carriers of dyes and drugs for bioimaging and, potentially, for therapeutic intervention.
Specificity and Diversity of Antibodies toMycobacterium tuberculosisArabinomannan (2003)

Arabinomannan (AM) is a polysaccharide antigen of the mycobacterial capsule. However, it is uncertain whether AM constitutes an immunologically distinct fraction of Mycobacterium tuberculosis. In this study, we analyzed the repertoire and specificity of antibodies to AM by using AM-binding murine monoclonal antibodies (MAbs) and human serum samples. Murine MAbs were found to be diverse in their specificity to AM and cross-reactivity with other arabinose-containing mycobacterial polysaccharides, with MAb 9d8 binding exclusively to AM. Human antibodies to AM were detected in serum samples from patients with pulmonary tuberculosis (TB), as well as in those from healthy, purified protein derivative-negative controls, with significantly higher titers among patients. The binding of human antibodies to AM was inhibited by MAb 9d8 in three patients with TB but not in controls. MAb 5c11, which recognizes other mycobacterial arabinose-containing carbohydrates in addition to AM, inhibited the binding of serum samples from 75% of patients and 76% of controls. Analysis of human antibodies with murine MAbs to human V(H) determinants demonstrated diversity among antibodies to AM with qualitative and quantitative differences compared with antibodies to lipoarabinomannan. In summary, our study suggests that antibodies to AM are diverse and heterogeneous with respect to antigen recognition and V(H) determinant expression, with human serum samples containing different subsets of antibodies to AM with the specificities of AM-binding murine MAbs. One MAb and a subset of human antibodies bind AM specifically, suggesting that this polysaccharide is antigenically distinct and is expressed in human infection.
Novel Mode of Microbial Energy Metabolism: Organic Carbon Oxidation Coupled to Dissimilatory Reduction of Iron or Manganese (1988)

A dissimilatory Fe(III)- and Mn(IV)-reducing microorganism was isolated from freshwater sediments of the Potomac River, Maryland. The isolate, designated GS-15, grew in defined anaerobic medium with acetate as the sole electron donor and Fe(III), Mn(IV), or nitrate as the sole electron acceptor. GS-15 oxidized acetate to carbon dioxide with the concomitant reduction of amorphic Fe(III) oxide to magnetite (Fe 3 O 4 ). When Fe(III) citrate replaced amorphic Fe(III) oxide as the electron acceptor, GS-15 grew faster and reduced all of the added Fe(III) to Fe(II). GS-15 reduced a natural amorphic Fe(III) oxide but did not significantly reduce highly crystalline Fe(III) forms. Fe(III) was reduced optimally at pH 6.7 to 7 and at 30 to 35°C. Ethanol, butyrate, and propionate could also serve as electron donors for Fe(III) reduction. A variety of other organic compounds and hydrogen could not. MnO 2 was completely reduced to Mn(II), which precipitated as rhodochrosite (MnCO 3 ). Nitrate was reduced to ammonia. Oxygen could not serve as an electron acceptor, and it inhibited growth with the other electron acceptors. This is the first demonstration that microorganisms can completely oxidize organic compounds with Fe(III) or Mn(IV) as the sole electron acceptor and that oxidation of organic matter coupled to dissimilatory Fe(III) or Mn(IV) reduction can yield energy for microbial growth. GS-15 provides a model for how enzymatically catalyzed reactions can be quantitatively significant mechanisms for the reduction of iron and manganese in anaerobic environments.
High power electrochemical capacitors based on carbon nanotube electrodes (1997)

Carbon nanotube sheet electrodes have been prepared from catalytically grown carbon nanotubes of high purity and narrow diameter distribution, centered around 80 Å. Our study shows that the electrodes are free-standing mats of entangled nanotubes with an open porous structure almost impossible to obtain with activated carbon or carbon fiber. These properties are highly desirable for high power and long cycle life electrochemical capacitors. Specific capacitances of 102 and 49 F/g were measured at 1 and 100 Hz, respectively, on a single cell device with 38 wt % H2SO4 as the electrolyte. The same cell had a power density of &amp;gt;8000 W/kg.
Design of a Remote Procedure Call system for object-oriented distributed programming (1998)

This paper describes the design of an RPC system for building object-oriented distributed software systems. The general requirements for such a system are to provide mechanisms for supporting inheritance, polymorphism, dynamic binding, and modular development in implementing distributed software systems. This paper presents the functionalities of this RPC system to support these general requirements. It also briefly describes the experiences with two previous versions of this system and how they led to the design of the final system. This system was implemented as a part of the programming environment of the Nexus distributed operating system. © 1998 John Wiley & Sons, Ltd.
Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes (1997)

Transcription of the human papillomavirus type 18 (HPV18) E6 and E7 oncogenes is repressed by the viral E2 protein. In C33 cells, we have previously shown that of the four E2 binding sites (E2 BS) present in the HPV18 long control region (LCR), only the binding site adjacent to the TATA box (E2 BS 1) was involved in E2-mediated repression. In the present study, we sought to determine whether this phenomenon was conserved in other cell lines. We first showed that all three E2 BS proximal to the P105 promoter were required for full repression of its activity in HeLa and HaCaT cells. Repression by E2 at E2 BS 2 occurred through the displacement of Sp1. Second, a truncated E2 product, lacking the N-terminal transactivation domain, repressed transcription more efficiently than the full-length protein. Repression was abolished when the N-terminal domain of E2 was replaced by the activation domain of VP16. The VP16-E2 chimeric protein could activate transcription from an LCR mutated in its TATA box. DNA-protein binding studies showed that E2 associates with its four binding sites in the LCR with similar affinities. However, challenge of such complexes with excess binding sites demonstrated that interaction with E2 BS 4 was the most stable while interaction with E2 BS 1 was the least stable. Furthermore, complexes with the full-length E2 were less stable than those formed with the N-terminally truncated protein.
Reprogramming of human fibroblasts toward a cardiac fate (2013)

Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of cardiac transcription factors or microRNAs has recently been demonstrated. The potential clinical applicability of these findings is based on the minimal regenerative potential of the adult human heart and the limited availability of human heart tissue. An initial but mandatory step toward clinical application of this approach is to establish conditions for conversion of adult human fibroblasts to a cardiac phenotype. Toward this goal, we sought to determine the optimal combination of factors necessary and sufficient for direct myocardial reprogramming of human fibroblasts. Here we show that four human cardiac transcription factors, including GATA binding protein 4, Hand2, T-box5, and myocardin, and two microRNAs, miR-1 and miR-133, activated cardiac marker expression in neonatal and adult human fibroblasts. After maintenance in culture for 4-11 wk, human fibroblasts reprogrammed with these proteins and microRNAs displayed sarcomere-like structures and calcium transients, and a small subset of such cells exhibited spontaneous contractility. These phenotypic changes were accompanied by expression of a broad range of cardiac genes and suppression of nonmyocyte genes. These findings indicate that human fibroblasts can be reprogrammed to cardiac-like myocytes by forced expression of cardiac transcription factors with muscle-specific microRNAs and represent a step toward possible therapeutic application of this reprogramming approach.
Reviews: Current Concepts in Alzheimer's Disease: A Multidisciplinary Review (2008)

This comprehensive, pedagogically-oriented review is aimed at a heterogeneous audience representative of the allied disciplines involved in research and patient care. After a foreword on epidemiology, genetics, and risk factors, the amyloid cascade model is introduced and the main neuropathological hallmarks are discussed. The progression of memory, language, visual processing, executive, attentional, and praxis deficits, and of behavioral symptoms is presented. After a summary on neuropsychological assessment, emerging biomarkers from cerebrospinal fluid assays, magnetic resonance imaging, nuclear medicine, and electrophysiology are discussed. Existing treatments are briefly reviewed, followed by an introduction to emerging disease-modifying therapies such as secretase modulators, inhibitors of Abeta aggregation, immunotherapy, inhibitors of tau protein phosphorylation, and delivery of nerve growth factor.
Expression, Purification, and Functional Analysis of Murine Ectodomain Fragments of CD8αα and CD8αβ Dimers (1999)

Soluble mouse CD8alphaalpha and CD8alphabeta dimers corresponding to the paired ectodomains (CD8(f)) or their respective component Ig-like domains (CD8) were expressed in Chinese hamster ovary cells or the glycosylation variant Lec3.2.8.1 cells as secreted proteins using a leucine zipper strategy. The affinity of CD8alphaalpha(f) for H-2K(b) as measured by BIAcore revealed a approximately 65 microM K(d), similar to that of CD8alphabeta(f). Consistent with this result, CD8alphaalpha(f) as well as CD8alphabeta(f) blocked the effector function of N15 T cell receptor transgenic cytolytic T cells in a comparable, dose-dependent fashion. Furthermore, both Lec3.2.8.1-produced and Chinese hamster ovary-produced CD8 homodimers and heterodimers were active in the inhibition assay. These results suggest that the Ig-like domains of CD8 molecules are themselves sufficient to block the requisite transmembrane CD8-pMHC interaction between cytolytic T lymphocytes and target cells. Moreover, given the similarities in co-receptor affinities for pMHC, the findings suggest that the greater efficiency of CD8alphabeta versus CD8alphaalpha co-receptor function on T cells is linked to differences within their membrane-bound stalk regions and/or intracellular segments. As recently shown for sCD8alphaalpha, the yield, purity and homogeneity of the deglycosylated protein resulting from this expression system is sufficient for crystallization and x-ray diffraction at atomic resolution.
Near-infrared light-responsive graphene oxide composite multilayer capsules: a novel route for remote controlled drug delivery (2012)

A novel and simple route for near-infrared (NIR)-light controlled release of drugs has been demonstrated using graphene oxide (GO) composite microcapsules based on the unique optical properties of GO. Upon NIR-laser irradiation, the microcapsules were ruptured in a point-wise fashion due to local heating which in turn triggers the light-controlled release of the encapsulated anticancer drug doxorubicin (Dox) from these capsules.
Evaluation of LMI1195, a Novel 18 F-Labeled Cardiac Neuronal PET Imaging Agent, in Cells and Animal Models (2011)

LMI1195 is a novel (18)F imaging agent retained in the heart through the NET and allowing evaluation of the cardiac sympathetic neuronal function by PET imaging.
Synthesis of Superconductive Oxides by Vacuum Calcination Method (1988)

The vacuum calcination method (VCM) was developed to synthesize Ln-Ba-Cu-O group superconductive oxides represented by YBa 2 Cu 3 O 7- x through solid phase reaction. When Y 2 O 3 , BaCO 3 and CuO are used as raw materials in the form of powder in this method, the carbon content of the resultant calcinated product will be 1/10 that of the normal methods or lower. VCM powder is a mixture of Y 2 BaCuO 5 and BaCu x O y , an unknown phase, and has extremely high activity because of oxygen content that is lower than the stoichiometric composition of YBa 2 Cu 3 O 7- x . For this reason, it absorbs oxygen during sintering under an oxidizing atmosphere causing transition to the perovskite phase of YBa 2 Cu 3 O 7- x , thus indicating excellent sinterability and high J c and magnetization.
Reliability of polymide/nitrate dielectrics for multilevel metallization systems (2003)

A comparison of combinations of polymide (PIQ-13) and Si/sub 3/N/sub 4/ dielectric layers is presented concerning their resistance against moisture uptake. Conventional oxide dielectrics are taken as a standard. A pressure-cooker test shows that a passivating Si/sub 3/N/sub 4/ layer on top of every polyimide layer results in a dielectric system whose reliability is comparable to conventional oxide dielectrics. Extremely low leakage currents of around 1 pA occur after the pressure-cooker test have been achieved and characterize the high level of reliability. It is concluded that a Si/sub 3/N/sub 4/ interlayer acts as a reliable adhesion layer to subsequent metal layers, and that it is necessary as an etch stop for subsequent metal etch processes in VLSI technology.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>