gebhart/patrepeval huggingface dataset:
Dynamic Eccentricity and Demagnetized Rotor Magnet Detection in Trapezoidal Flux (Brushless DC) Motors Operating Under Different Load Conditions (2007)

Brushless dc (BLDC) machines are finding increasing use in applications that demand high and rugged performance. Automotive and aerospace are some such areas where these machines may be used. In this context, condition monitoring of these machines would provide added value. This paper investigates the effect of several potential rotor faults on the current spectrum of BLDC motors with a view to develop an effective condition-monitoring scheme. The effect of load unbalances, misalignments, and varying load torques on the diagnosis of such machines is investigated. A method to estimate the strength of the rotor magnets is also provided. Simulation and experimental results are presented to substantiate that current signature analysis could be a viable tool for diagnosing the condition of BLDC machines.
[Paralytic ileus as an initial manifestation of malignant VIPoma of the pancreas--case report with review of the literature]. (1990)

A 57-year old patient with a paralytic ileus of unknown origin was admitted to the intensive care unit. Because of the laboratory findings with therapy resistant hypokalemia, hypercalcemia and metabolic acidosis a VIPoma was suspected. Therapy with somatostatin resulted in correction of laboratory abnormalities and in normalization of gastrointestinal motility. Plasma concentrations of VIP and PP were elevated, ultrasonography revealed a pancreatic tumor. Postsurgical examination of the removal tumor tissue confirmed the diagnosis of a malignant VIPoma. Clinical symptoms, laboratory findings with and without somatostatin-therapy and immunhistochemical properties are described.
Genome Analysis Reveals Pili in Group B Streptococcus (2005)

Pili are essential virulence factors in many Gram-negative bacteria; however, they have not been described in most important Gram-positive pathogens. While screening the sequence of multiple genomes of Group B Streptococcus, we identified protective antigens that formed high molecular weight polymers. Immunogold electron microscopy revealed that the structures have a pilus-like form. These large structures have gone unrecognized in decades of studies of Group B Streptococcus.
Improved chemiluminescent western blotting procedure. (1992)

A chemiluminescent Western blotting procedure and its application in assays for human transferrin and human immunodeficiency virus-I antibodies are described. The procedure is based on a chemiluminescent substrate, adamantyl 1,2-dioxetane aryl phosphate and alkaline phosphatase-labeled detection antibodies. Different membranes (polyvinylidene fluoride, nitrocellulose, nylon) and a proprietary membrane treatment agent (Nitro-Block) have been studied. This sensitive blotting procedure utilizing AMPPD, a polyclonal rabbit anti-transferrin:goat anti-rabbit IgG-alkaline phosphatase detection complex, and a PVDF membrane blocked with Nitro-Block permits the detection of 125 pg (1.6 fmol) of human transferrin. A novel 1,2-dioxetane substrate, CSPD, has also been evaluated.
Actions of progestins for the inhibition of cervical ripening and uterine contractions to prevent preterm birth. (2012)

The importance of progesterone (P4) for maintenance of pregnancy, its role in cervical ripening and uterine contractions is at least partly established and therefore, not surprisingly, the basis for the concept to use P4 as a treatment for preterm birth. Due to the complexity of the condition of preterm birth there are still questions concerning the optimal population that might benefit, timing of treatment, dosage, vehicle and route of administration. Recently vaginal P4 and intramuscular 17-alpha-hydroxyprogesterone caproate (17P) have been used to prevent preterm birth in patients with a high risk for early delivery. The aim of this study was to assess cervical changes throughout pregnancy in rats and the timing of term and preterm delivery after various progestin treatments given by different routes and vehicles in hope of identifying better treatment regimens. This paper presents results that suggest that there are better routes of treatment than the vaginal route (e.g. topical), that the vehicle used in many of the clinical studies (Replens®) is not appropriate due to a low release of the steroid and consequently low uptake of P4, and that inhibition of birth is primarily due to inhibition of uterine contractility that can be achieved by supplementation of P4 but not with 17P.
Proprotein Convertases Process Pmel17 during Secretion (2011)

Pmel17 is a melanocyte/melanoma-specific protein that traffics to melanosomes where it forms a fibrillar matrix on which melanin gets deposited. Before being cleaved into smaller fibrillogenic fragments the protein undergoes processing by proprotein convertases, a class of serine proteases that typically recognize the canonical motif RX(R/K)R↓. The current model of Pmel17 maturation states that this processing step occurs in melanosomes, but in light of recent reports this issue has become controversial. We therefore addressed this question by thoroughly assessing the processing kinetics of either wild-type Pmel17 or a secreted soluble Pmel17 derivative. Our results demonstrate clearly that processing of Pmel17 occurs during secretion and that it does not require entry of the protein into the endocytic system. Strikingly, processing proceeds even in the presence of the secretion inhibitor monensin, suggesting that Pmel17 is an exceptionally good substrate. In line with this, we find that newly synthesized surface Pmel17 is already quantitatively cleaved. Moreover, we demonstrate that Pmel17 function is independent of the sequence identity of its unconventional proprotein convertase-cleavage motif that lacks arginine in P4 position. The data alter the current view of Pmel17 maturation and suggest that the multistep processing of Pmel17 begins with an early cleavage during secretion that primes the protein for later functional processing.
Hybridised fabrication process for optical fibres (1996)

A new hybridised process for singlemode optical fibres has been developed. The process consists of overcladding a VAD-derived core rod with a tubular porous body made from commercial silica powder using a compression forming technique. Optical fibres consisting of 95% powder-derived and 5% VAD-derived silica are fabricated with losses of 0.392 dB/km at 1.3 µm and 0.275 dB/km at 1.55 µm.
Phosphorylation of smg p21B/rap1B p21 by cyclic GMP‐dependent protein kinase (1992)

smg p21B/rap1B p21, a member of ras p21-like small GTP-binding protein superfamily, has been shown to be phosphorylated by cyclic AMP-dependent protein kinase (protein kinase A). We show here that this protein was also phosphorylated by cyclic GMP-dependent protein kinase (protein kinase G) in a cell-free system. The same serine residue (Ser179) in the C-terminal region was phosphorylated by both protein kinases G and A. The Km and Vmax values of smg p21B for protein kinase G were 5 x 10(-7) M and 4 x 10(-9) mol/min/mg, and those values for protein kinase A were 1 x 10(-7) M and 3 x 10(-8) mol/min/mg.
Antigenicity of rabies virus glycoprotein (1991)

Although the number of antigenic sites on the rabies virus glycoprotein that have been described regularly increases with time, no attempt has been made to carefully evaluate the relative importance of each of these sites. Here we provide a more precise description of the antigenicity of the protein in mice of the H-2d haplotype; we developed this description by using 264 newly isolated monoclonal antibodies (MAbs) and a collection of neutralization-resistant (MAR) mutants. Most of the MAbs (97%) recognized antigenic sites previously described as II and III. One minor antigenic site separated from site III by three amino acids, including a proline, was identified (minor site a). Despite their proximity, there is no overlap between site III and minor site a; i.e., site III-specific MAR mutants were neutralized by the six MAbs defining minor site a, and vice versa. One of our MAbs, 1D1, reacted with sodium dodecyl sulfate-treated glycoprotein in Western blots (immunoblots) under reducing conditions and was therefore probably directed against a linear epitope, A MAR mutant selected with this MAb was still neutralized by MAbs of other specificities. This linear epitope was called G1 (G, Gif). As a general rule, we propose to reserve the term "antigenic site" (either major or minor) for regions of the protein which are defined by several MAbs originating from different fusions and to describe regions of the protein which are defined by a single MAb as epitopes. It would be interesting to test whether the same regions of the rabies virus glycoprotein are antigenic in mice of different haplotypes or in other species.
Palladium-Catalyzed, Ligand-Free Suzuki Reaction in Water Using Aryl Fluorosulfates (2015)

Aryl fluorosulfates were prepared by a simple method and employed as coupling partners in the Suzuki-Miyaura reaction. The cross-coupling reactions were performed in water under air at room temperature without ligands or additives such as surfactants or phase-transfer reagents and proceeded smoothly to give excellent yields. Aryl fluorosulfates could also be used as alternatives to halides or triflates in other coupling reactions.
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia (2003)

Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or factors that cause maternal endothelial dysfunction, resulting in the clinical findings of hypertension, proteinuria, and edema. Here, we confirm that placental soluble fms-like tyrosine kinase 1 (sFlt1), an antagonist of VEGF and placental growth factor (PlGF), is upregulated in preeclampsia, leading to increased systemic levels of sFlt1 that fall after delivery. We demonstrate that increased circulating sFlt1 in patients with preeclampsia is associated with decreased circulating levels of free VEGF and PlGF, resulting in endothelial dysfunction in vitro that can be rescued by exogenous VEGF and PlGF. Additionally, VEGF and PlGF cause microvascular relaxation of rat renal arterioles in vitro that is blocked by sFlt1. Finally, administration of sFlt1 to pregnant rats induces hypertension, proteinuria, and glomerular endotheliosis, the classic lesion of preeclampsia. These observations suggest that excess circulating sFlt1 contributes to the pathogenesis of preeclampsia.
KUAR: A Flexible Software-Defined Radio Development Platform (2007)

In this paper, we present the details of a portable, powerful, and flexible software-defined radio development platform called the Kansas University Agile Radio (KUAR). The primary purpose of the KUAR is to enable advanced research in the areas of wireless radio networks, dynamic spectrum access, and cognitive radios. The KUAR hardware implementation and software architecture are discussed in detail. Radio configurations and applications are presented. Future research made possible by this flexible platform is also discussed.
ANÁLISE DIALÉLICA DE SEIS CARACTERÍSTICAS AGRONÔMICAS EM PHASEOLUS VULGARIS L. (1998)

Os cultivares de feijão-de-vagem Alessa, Hab 52 e Hab 198, as linhagens de feijão comum Bac-6 e A-794 e os dez possíveis híbridos F1s dialélicos foram avaliados quanto ao número de vagens e de sementes por planta, comprimento, diâmetro e teor de fibra da vagem e altura de planta. A análise dialélica foi feita com base no método II, modelo 1 de Griffing. A capacidade geral de combinação foi significativa para todos os caracteres avaliados. Efeitos significativos para a capacidade específica de combinação foram observados para diâmetro e teor de fibra da vagem e altura de planta. Constatou-se que os efeitos de aditividade foram superiores aos de dominância para número de vagens e de sementes por planta, comprimento e teor de fibra da vagem, identificando-se os genótipos Bac-6, A-794 e 'Alessa' como os mais promissores. Para os demais caracteres, os efeitos de dominância se sobrepuseram aos de aditividade, permitindo-se destacar as combinações 'Alessa' x Bac-6, 'Alessa' x A-794 e 'Hab 52' x Bac-6.
A Predictive Toxicological Paradigm for the Safety Assessment of Nanomaterials (2009)

The rate of expansion of nanomaterials calls for the consideration of appropriate toxicological paradigms in the safety assessment of nanomaterials. We advocate a predictive toxicological paradigm for the assessment of nanomaterial hazards. The predictive toxicological approach is defined as establishing and using mechanisms and pathways of injury at a cellular and molecular level to prioritize screening for adverse biological effects and health outcomes in vivo. Specifically as it relates to nanomaterials, a predictive approach has to consider the physicochemical properties of the material that leads to molecular or cellular injury and also has to be valid in terms of disease pathogenesis in whole organisms.
Inhibition of NKG2D receptor function by antibody therapy attenuates transfer‐induced colitis in SCID mice (2007)

A role for the activating NK-receptor NKG2D has been indicated in several autoimmune diseases in humans and in animal models of type 1 diabetes and multiple sclerosis, and treatment with monoclonal antibodies to NKG2D attenuated disease severity in these models. In an adoptive transfer-induced model of colitis, we found a significantly higher frequency of CD4(+)NKG2D(+) cells in blood, mesenteric lymph nodes, colon, and spleen from colitic mice compared to BALB/c donor-mice. We, therefore, wanted to study the effect of anti-NKG2D antibody (CX5) treatment initiated either before onset of colitis, when the colitis was mild, or when severe colitis was established. CX5 treatment decreased the detectable levels of cell-surface NKG2D and prophylactic administration of CX5 attenuated the development of colitis significantly, whereas a more moderate reduction in the severity of disease was observed after CX5 administration to mildly colitic animals. CX5 did not attenuate severe colitis. We conclude that the frequency of CD4(+)NKG2D(+) cells increase during development of experimental colitis. NKG2D may play a role in the early stages of colitis in this model, since early administration of CX5 attenuated disease severity.
Manhattan or non-Manhattan? (2000)

Circuit interconnect has become a substantial obstacle in the design of high performance systems. In this paper we explore a new routing paradigm that strikes at the root of the interconnect problem by reducing wire lengths directly. We present a non-Manhattan Steiner tree heuristic, obtaining wire length reductions of much as 17% on average, when compared to rectilinear topologies. Moreover, we present a graph-based interconnect optimization algorithm, called the GRATS-tree algorithm, which allows performance optimization beyond what can be obtained through wire length reduction alone. The two tree construction algorithms are integrated into a new global router that allows large scale non-Manhattan design. Although we consider circuit placements performed under rectilinear objectives, our global router can reduce maximum congestion levels by as much as 20%. In general we find that the non-Manhattan approach requires additional Steiner points and bends; realization of non-Manhattan routing structures requires additional vias. We observe that the increase in via cost is much less dramatic than might be expected; the benefits of wire length reduction may outweigh the additional via cost.
A subsystem for swapping and mapped file I/O on top of Chorus (2002)

Chorus is a micro-kernel-based distributed operating system architecture. The authors explore the architectural and implementational issues involved in constructing a distributed paging service in the Chorus environment. Apart from outlining the pager architecture, they provide insight into how the characteristic goals of a critical distributed application on top of the Chorus system may be put into practice. The respective Chorus features are thereby judged in view of their suitability with respect to the pager implementation. The results of an experimental evaluation of the pager are included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Petri Net-Based Optimal One-Wafer Cyclic Scheduling of Hybrid Multi-Cluster Tools in Wafer Fabrication (2014)

In a multi-cluster tool, there may be both single and dual-arm cluster tools. Such a multi-cluster tool is called hybrid multi-cluster tool. To operate such a multi-cluster tool, one needs to coordinate different types of robots for accessing the shared buffering modules. Aiming at finding a one-wafer periodic schedule such that the lower bound of cycle time can be reached, this paper conducts a study on scheduling a hybrid multi-cluster tool with its bottleneck tool being process-bound. The tool is modeled by a kind of timed Petri net model. With this model, the scheduling problem is reduced to determining the robots' waiting time. Then, the conditions under which a one-wafer periodic schedule exists such that the lower bound of cycle time can be reached are presented. Based on them, a closed-form algorithm is given to check whether such a one-wafer periodic schedule exists. If so, it is found via simple calculation. Examples are given to show the application of the proposed method.
Prostate cancer stem cells: The case for model systems (2012)

Advanced prostate cancers are treated with androgen deprivation therapy, which usually leads to a rapid and significant reduction in tumor burden but subsequent development of castration-resistant and metastatic disease almost always occurs. The source of tumor heterogeneity and the accompanying mechanisms leading to treatment resistance are major areas of prostate cancer research. Although our understanding of tumor heterogeneity is evolving, the functional isolation of tumor propagating populations, also known as cancer stem cells (CSCs), is fundamental to the identification and molecular characterization of castration-resistant prostate cancer cells. Of clinical importance, knowledge of prostate CSCs has implications for design of next generation-targeted therapies aimed at both eradicating primary tumor mass and preventing castration-resistant disease. The inability to routinely transplant fractionated primary human prostate tumors has prevented progress in analyzing the source of heterogeneous and treatment-resistant populations in prostate cancer. Here, we briefly overview the mechanisms of castration resistance, including the hypothesis for the existence of androgen-independent prostate CSCs. Finally, we discuss the interpretation of preclinical models and their utility for characterizing prostate CSCs in androgen-replete and androgen-deprived conditions.
Enhancement of the Infectivity of Simian Virus 40 Deoxyribonucleic Acid With Diethylaminoethyl-Dextran<xref ref-type="fn" rid="FN2">2</xref> (1968)

The infectivity of viral RNA for mammalian cells in culture is greatly enhanced by diethylaminoethyl-dextran (DEAE-D). In this work a similar enhancing effect is shown for the infectious DNA of simian virus 40 (SV40). This phenomenon has enabled the development of a sensitive plaque method for the assay of infectious viral DNA; the reliability of the assay is in part accounted for by elimination of the need for exposure of the assay cells to hypertonic media. DEAE-D in Tris-buffered isosmolar media in concentrations of from 100 to 3000 μg/ml increases the infectivity of SV40 DNA up to 100,000 times. With DEAE-D's of molecular weight 26,000 to 2,000,000, DNA infectivity was directly related to molecular weight of DEAE-D. Paradoxically, DEAE-D produced a 20-fold reduction in infectivity of intact SV40. The degree of inhibition also depended on the molecular weight of DEAE-D, the number of SV40 plaques being inversely related to molecular weight. Since as much as 0.1% of viral infectivity can be recovered in the extracted DNA, it is now possible to prepare SV40 DNA with an infectivity titer high enough to initiate synchronous infection of all the cells in a culture.
The Influence of the Psyche and the Brain on Immunity and Disease Susceptibility: A Critical Review (1979)

In critically reviewing the sources of evidence connecting psyche and brain with the immune system, the authors include a brief review of current knowledge of the immune system, its interactions with the neuroendocrine system, and other factors influencing its regulation. These include developmental stages, aging, rhythmicity, and a variety of exogenous influences. The need for developing further information about normal base lines is emphasized. Against that background, many sources of data demonstrating connections between the central nervous system and the immune system are presented: indirect evidence from clinical and experimental illnesses involving the immune system, and direct changes in either humoral or cellular immunity after natural or experimental stress, conditioning, hypnosis, and direct brain stimulation. Possible mechanisms are discussed, as well as some important methodological issues for further research.
Distributed and Parallel Computing Issues in Data Warehousing (Invited Talk) (1998)

A data warehouse is a repository of data that has been extracted and integrated from heterogeneous and autonomous distributed sources. The warehouse data is used for decision-support or data mining. In this paper we illustrate some of the challenges in distributed and parallel computing faced by such systems. Our examples come from research done in the Stanford WHIPS Project. 1 Introduction A data warehouse is a repository of data that has been extracted and integrated from heterogeneous and autonomous distributed sources. For example, a grocery store chain might integrate data from its inventory database, sales databases from different stores, and its marketing department&amp;apos;s promotions records. The store chain could then: (1) find out how sales trends differ across regions of the country or world; (2) correlate its inventory with current sales and ensure that each store&amp;apos;s inventory is replaced in keeping with its sales; (3) analyze which promotions lead to increased product sales. For...
The linkage of cytotoxic drugs to monoclonal antibodies for the treatment of cancer (1990)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe linkage of cytotoxic drugs to monoclonal antibodies for the treatment of cancerGeoffrey A. PieterszCite this: Bioconjugate Chem. 1990, 1, 2, 89–95Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://doi.org/10.1021/bc00002a001RIGHTS & PERMISSIONSArticle Views428Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (916 KB) Get e-Alerts Get e-Alerts