gebhart/patrepeval huggingface dataset:
Preliminary Considerations on Application of Steamflooding in a Toe-to-Heel Configuration (2009)

Abstract With the advent of horizontal wells, a distinct change is tacitly taking place in our approach to the improved recovery of heavy oil—from displacing mobilized oil in a flood pattern from injector to producers over long distances on the order of hundreds of metres to short-distance oil displacement (SDOD) processes (typically over a few tens of metres). SDOD processes comprise Steam Assisted Gravity Drainage (SAGD), Cyclic Steam Stimulation (CSS) and Toe-to-Heel (TTH) Displacement Processes, which comprise Toe-to-Heel Air Injection (THAI), with its variant catalytic THAI (CAPRI), and Toe-to-Heel Waterflooding (TTHW). Presently SAGD is commercially used, while THAI has been under field testing for 3 years; testing of CAPRI is scheduled to start in 2010. TTHW has been under field testing both in the US and Canada for more than 4 years. Steamflooding in a TTH configuration (TTH steamflooding) uses vertical wells as injectors and horizontal wells as producers, arranged in a staggered line drive, with producers having their toes close to the shoes of vertical injectors; the horizontal section of producers is located at the base of the pay. The vertical wells are used for initiating the steam front, which subsequently is anchored at the toe of the horizontal producer; it is then propagated towards the producer's heel. In TTH steamflooding, the existing deficiency of conventional steamflooding schemes in terms of low vertical sweep is overcome by the beneficial use of gravity. To investigate the potential of TTH steamflooding, some laboratory tests were conducted. The objective was to assess the feasibility of TTH steam and thermo-solvent flooding (steam+propane co-injection) by carrying out 3D model experiments using heavy oil with a viscosity of 15,000 cP. Laboratory results showed that the concepts of TTH steamflooding and TTH steamflooding with solvent are feasible. All in all, stability of TTH steamflooding was relatively good, while the stability of TTH steamflooding with the addition of nitrogen or propane was much better. Significant improvements in design and operation of these processes were needed in order to promote override during the early phase, and obtain a stable and efficient process. The improvements included a cold (gas fingering) and a hot (steam-based) communication phase; and controlling lateral spread of steam by using two additional vertical control wells (positioned laterally but close to the heel of the horizontal producer) for conducting a limited steamflood. Nitrogen was injected along with steam in the conventional steamflood; propane replaced nitrogen in TTH steamflooding with solvent.
Both Variant Forms of Interferon-α4 Gene (IFNA4a and IFNA4b) Are Present in the Human Population (1997)

Alpha interferons (IFN-alpha) are a class of cytokines with various activities that are used as therapeutic agents for treatment of cancer and viral and immune disorder diseases. At least 13 IFN-alpha genes and 1 IFN-alpha pseudogene have been identified, which are clustered on human chromosome 9. Among the known IFN-alpha species, a number of allelic variants have been reported. Two variants of IFN-alpha4 (IFN-alpha4a and IFN-alpha4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. We have developed oligonucleotide primers for specific amplification of IFN-alpha4 gene fragments using the polymerase chain reaction (PCR). Genomic DNA obtained from over 28,000 normal healthy individuals and six human cell lines were used in this study. The resulting PCR products were analyzed by restriction endonuclease digestion and DNA sequencing to identify the presence of variant sequences. The results show that the DNA sequences for both variants of IFN-alpha4 are found in the population in nearly equal proportion. Individuals with either homozygous (e.g., alpha4a/alpha4a or alpha4b/alpha4b) or heterozygous (i.e., alpha4a/alpha4b) IFN-alpha4 genes were detected. Among the cell lines, KG-1, EB-3, and HTB-10 cells contain the genes for IFN-alpha4a only, whereas U-937, Namalwa, and Daudi cells contain the genes for both IFN-alpha4a and IFN-alpha4b.
Effect of the magnetic properties of the inclusions on the high-frequency dielectric response of diluted composites (2002)

The high-frequency permittivity of composites consisting of a lattice of ferromagnetic wires is investigated. Experimental results using free space or coaxial line microwave measurements are reported. It is shown that the dielectric response is strongly dependent on the magnetic properties of the wires. Negative real permittivity is observed over a wide frequency range for wires with circumferential magnetization, while a resonant behavior is observed on wires with an axially magnetized core. In addition, it is shown that a moderate external field can induce large changes in the dielectric response. We prove that the underlying physics of these composites made of oriented magnetic wires is basically the same as the giant magnetoimpedance (GMI) effect. A model based on GMI equations is proposed which predicts this unusual dielectric phenomenon.
Recent advances in the molecular genetics of epilepsy (2013)

Recent advances in molecular genetics have translated into the increasing utilisation of genetic testing in the routine clinical practice of neurologists. There has been a steady, incremental increase in understanding the genetic variation associated with epilepsies. Genetic testing in the epilepsies is not yet widely practiced, but the advent of new screening technologies promises to exponentially expand both knowledge and clinical utility. To maximise the value of this new genetic insight we need to rapidly extrapolate genetic findings to inform patients of their diagnosis, prognosis, recurrence risk and the clinical management options available for their specific genetic condition. Comprehensive, highly specific and sensitive genetic test results improve the management of patients by neurologists and clinical geneticists. Here we discuss the latest developments in clinical genetic testing for epilepsy and describe new molecular genetics platforms that will transform both genetic screening and novel gene discovery.
Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury (1998)

Thrombin is generated during tissue damage in several organs, including the liver, and participates in the process of tissue repair through proteolytic activation of a specific thrombin receptor (TR). The aim of this study was to investigate TR expression in human liver by immunohistochemistry and in situ hybridization. In normal liver, immunostaining for TR was present in the endothelial lining of the hepatic sinusoids. During chronic hepatitis, several cells expressing the TR were detected in the inflammatory infiltrate of portal tracts. In cirrhosis with chronic active hepatitis, expression of the TR was also present in mesenchymal cells of fibrous septa. TR expression was markedly up-regulated during fulminant hepatitis, with the highest expression in mesenchymal cells in areas of regeneration. Up-regulation of TR expression was associated with increased levels of TR messenger RNA (mRNA), as assessed by in situ hybridization and RNAse protection assay of liver RNA. Immunostaining of serial sections using specific cellular markers showed that different nonparenchymal cells contribute to TR expression during liver injury. TR expression was also shown in cultured human hepatic stellate cells, with increasing signal comparing activated versus quiescent cells. Because thrombin is rapidly generated after tissue damage, regulated TR expression may be involved in tissue remodeling and/or scarring during liver damage.
THE ALOE VERA PLANT (1944)

A number of interesting articles have appeared giving quaint historical lore and scientific application of the Aloe vera leaf for dermatologic purposes.<sup>1</sup>Particular application of the leaf has been recommended in radiodermatitis. The first article published on the use of the Aloe vera leaf in radiodermatitis was written by C. E. Collins and Creston Collins.<sup>1b</sup>Dr. C. E. Collins<sup>2</sup>first became interested in the therapeutic use of the leaves in 1935, his son Dr. Creston Collins having seen the Seminole Indians using the leaf of the plant to treat burns. These physicians then applied the leaf for the treatment of radiodermatitis, with encouraging results. Since then, it has become widely used for this purpose. In New York the leaf is a relatively rare and expensive product, often kept wrapped in tinfoil and usually refrigerated. (It is best kept at room temperature.) Recently while
A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development (2015)

O-GlcNAcylation is a reversible type of serine/threonine glycosylation on nucleocytoplasmic proteins in metazoa. Various genetic approaches in several animal models have revealed that O-GlcNAcylation is essential for embryogenesis. However, the dynamic changes in global O-GlcNAcylation and the underlying mechanistic biology linking them to embryonic development is not understood. One of the limiting factors towards characterizing changes in O-GlcNAcylation has been the limited specificity of currently available tools to detect this modification. In the present study, harnessing the unusual properties of an O-GlcNAcase (OGA) mutant that binds O-GlcNAc (O-N-acetylglucosamine) sites with nanomolar affinity, we uncover changes in protein O-GlcNAcylation as a function of Drosophila development.
Extending the performance of optically sampled time-demultiplexed analog-to-digital converters (2000)

Summary form only given.Analog-to-digital converters face severe performance constraints on bandwidth and accuracy because of limitations imposed by the input track-and-hold circuits that perform the sampling function. Optical sampling offers a way to dramatically enhance both the timing precision and linearity of the sampling function. A/D converters utilizing optical sampling have the potential for operating at multi-GHz sampling rates with >12-bit precision. The primary limitation of previously reported optical-sampling systems has been the nonlinearity of the sampling device. Our use of phase-encoded optical sampling overcomes this limitation at the expense of added complexity. We describe a system that combines phase-encoded optical sampling with time-division demultiplexing to distribute the sampled data to an array of commercial quantizers.
BotSniffer: Detecting Botnet Command and Control Channels in Network Traffic (2008)

Botnets are now recognized as one of the most serious security threats. In contrast to previous malware, botnets have the characteristic of a command and control (C&C) channel. Botnets also often use existing common protocols, e.g., IRC, HTTP, and in protocol-conforming manners. This makes the detection of botnet C&C a challenging problem. In this paper, we propose an approach that uses network-based anomaly detection to identify botnet C&C channels in a local area network without any prior knowledge of signatures or C&C server addresses. This detection approach can identify both the C&C servers and infected hosts in the network. Our approach is based on the observation that, because of the pre-programmed activities related to C&C, bots within the same botnet will likely demonstrate spatial-temporal correlation and similarity. For example, they engage in coordinated communication, propagation, and attack and fraudulent activities. Our prototype system, BotSniffer, can capture this spatial-temporal correlation in network traffic and utilize statistical algorithms to detect botnets with theoretical bounds on the false positive and false negative rates. We evaluated BotSniffer using many real-world network traces. The results show that BotSniffer can detect real-world botnets with high accuracy and has a very low false positive rate.
Androgen Deprivation Therapy for Prostate Cancer (2005)

Androgen deprivation therapy has clear roles in the management of advanced prostate cancer and high-risk localized disease. The benefits of ADT in other settings need to be weighed carefully against substantial risks and adverse effects on quality of life.
c-Met Inhibitors with Novel Binding Mode Show Activity against Several Hereditary Papillary Renal Cell Carcinoma-related Mutations (2007)

c-Met is a receptor tyrosine kinase often deregulated in human cancers, thus making it an attractive drug target. One mechanism by which c-Met deregulation leads to cancer is through gain-of-function mutations. Therefore, small molecules capable of targeting these mutations could offer therapeutic benefits for affected patients. SU11274 was recently described and reported to inhibit the activity of the wild-type and some mutant forms of c-Met, whereas other mutants are resistant to inhibition. We identified a novel series of c-Met small molecule inhibitors that are active against multiple mutants previously identified in hereditary papillary renal cell carcinoma patients. AM7 is active against wild-type c-Met as well as several mutants, inhibits c-Met-mediated signaling in MKN-45 and U-87 MG cells, and inhibits tumor growth in these two models grown as xenografts. The crystal structures of AM7 and SU11274 bound to unphosphorylated c-Met have been determined. The AM7 structure reveals a novel binding mode compared with other published c-Met inhibitors and SU11274. The molecule binds the kinase linker and then extends into a new hydrophobic binding site. This binding site is created by a significant movement of the C-helix and so represents an inactive conformation of the c-Met kinase. Thus, our results demonstrate that it is possible to identify and design inhibitors that will likely be active against mutants found in different cancers.
Combining multiple anatomical MRI measures improves Alzheimer's disease classification (2016)

Several anatomical MRI markers for Alzheimer's disease (AD) have been identified. Hippocampal volume, cortical thickness, and grey matter density have been used successfully to discriminate AD patients from controls. These anatomical MRI measures have so far mainly been used separately. The full potential of anatomical MRI scans for AD diagnosis might thus not yet have been used optimally. In this study, we therefore combined multiple anatomical MRI measures to improve diagnostic classification of AD. For 21 clinically diagnosed AD patients and 21 cognitively normal controls, we calculated (i) cortical thickness, (ii) cortical area, (iii) cortical curvature, (iv) grey matter density, (v) subcortical volumes, and (vi) hippocampal shape. These six measures were used separately and combined as predictors in an elastic net logistic regression. We made receiver operating curve plots and calculated the area under the curve (AUC) to determine classification performance. AUC values for the single measures ranged from 0.67 (cortical thickness) to 0.94 (grey matter density). The combination of all six measures resulted in an AUC of 0.98. Our results demonstrate that the different anatomical MRI measures contain complementary information. A combination of these measures may therefore improve accuracy of AD diagnosis in clinical practice. Hum Brain Mapp 37:1920-1929, 2016. © 2016 Wiley Periodicals, Inc.
The inhibition of tumor growth by tumor mass. (1991)

Evidence suggests that a tumor behaves, in its pattern of growth, like an integrated organ rather than a collection of independently growing cells. Tumor growth tends to slow progressively as size increases and to undergo compensatory growth after partial resection. Consequently, therapies that reduce tumor mass may tend to accelerate the growth of the remaining tumor and tumor metastases. An approach to therapy based upon a simulated increase in tumor mass may be worthy of consideration.
Secondary Ion Mass Spectrometry: A Practical Handbook for Depth Profiling and Bulk Impurity Analysis (1989)

ANALYSIS CONDITIONS. Primary Beam. Primary Beam Energy. Angle of Incidence. Sputtering Rate. Detected Area. Species Monitored. End Point. Energy Distribution. PROFILE ISSUES. Ion Beam Mixing and Depth Resolution. Segregation and Charge Driven Diffusion. Matrix Effects. Surface Effects. Particulates. Crate Shape. Microtopography. Memory Effect. Count Rate Saturation. Sample Location and Mounting. Mass Interferences. QUANTIFICATION. Procedure. Calibration Using Ion Implantation. Systematic Trends in RSFs. SPECIFIC APPLICATIONS. Bulk Analysis. Metals and Rough Surfaces. Insulators. Interfaces. Multilayers. Residual Gas Elements. Small Areas. Major Elements. Appendices. Index.
Characterization of the mgl operon of Escherichia coli by transposon mutagenesis and molecular cloning (1983)

We used transposon insertion mutagenesis, molecular cloning, and a novel procedure for in vitro construction of polar and nonpolar insertion mutations to characterize the genetic organization and gene products of the beta-methylgalactoside (Mgl) transport system, which utilizes the galactose-binding protein. The data indicate that the mgl operon contained three genes, which were transcribed in the order mglB, mglA, and mglC. The first gene coded for the 31,000 Mr galactose-binding protein, which was synthesized as a 3,000-dalton-larger precursor form. The mglA product was a 50,000 Mr protein which was tightly associated with the membrane, and the mglC product was a 38,000 Mr protein which was apparently loosely associated with the membrane and was probably located on the internal face of the cytoplasmic membrane. Identification of gene products was facilitated by in vitro insertion of a fragment of Tn5 containing the gene conferring kanamycin resistance into a restriction site in the operon. The fragment proved to have a polar effect on the expression of promoter-distal genes only when inserted in one of the two possible orientations. The three identified gene products were necessary and apparently sufficient for transport activity, but only the binding protein was required for chemotaxis towards galactose. The transport system appeared to contain the minimum number of components for a binding protein-related system: a periplasmic recognition component, a transmembrane protein, and a peripheral membrane protein that may be involved in energy linkage.
Prognostic and predictive value of MET deregulation in non-small cell lung cancer. (2015)

Recent progress in cancer biology has led to the discovery of increasing number of oncogene alterations that have dramatically changed the paradigm of lung cancer treatment. MET is a tyrosine kinase receptor for the hepatocyte growth factor (HGF) that is deregulated in several malignancies, including non-small cell lung cancer (NSCLC). Abnormal MET-HGF signaling pathway activation can occur via different mechanisms, including HGF and/or MET overexpression, MET gene amplification, mutations or rearrangements. MET protein overexpression and increased MET gene number have been identified as poor prognostic factors in several series of surgically resected NSCLC making this receptor an attractive target for cancer treatment. Several clinical trials have recently evaluated the activity of a variety of anti-MET strategies in NSCLC patients with or without molecular selection with a variable degree of success, underscoring the need of establishing the best predictive biomarker for the identification of responding patients.
Gençlik, sevgi, terbiye ve olgun insan (2019)

İnsanda fıtri olan sevgiyi, iyi yönde geliştirmekle, gençlerimizde ve çocuklarımızda arzu ettiğimiz eğitim ve terbiyeli gerçekleştirebileceğimize inanıyoruz. İnsanın önce kendini ve Rab'bini tanıması, bu kainatla beraber, kendi yaratılışının hikmetini kavraması, Yaratan'ına, kendine ve başkalarına, karşı yapması ger'eken vazifelerini, hak ve hakikate uygun olarak, olgun insanlara yakışır bir biçimde, eda etmesi lazımdır. Her şey, iç arzusu ve isteğiyle, gönülden gelen aşk ve sevgiyle .olacağına göre, bize en yakın olmaları sebebiyle, talebelerimiz ve üniversite gençliğimize bu sevgiyi nasıl verebileceğimizin hesabı yapılmıştır.
Globally optimal regions and boundaries (1999)

We propose a new form of energy functional for the segmentation of regions in images, and an efficient method for finding its global optima. The energy can have contributions from both the region and its boundary, thus combining the best features of region- and boundary-based approaches to segmentation. By transforming the region energy into a boundary energy, we can treat both contributions on an equal footing, and solve the global optimization problem as a minimum mean weight cycle problem on a directed graph. The simple, polynomial-time algorithm requires no initialization and is highly parallelizable.
Overstress-Free 4 × VDD Switch in a Generic Logic Process Supporting High and Low Voltage Modes (2015)

A four-times-VDD switch that supports high and low voltage mode operations is demonstrated in a generic 65 nm logic process. The proposed switch shows the robust operation for supply voltages ranging from VDD to 4 × VDD. A cascaded voltage switch and a voltage doubler based charge pump generate the intermediate supply voltage levels required for the proposed high voltage switch. All the high voltage circuits developed in this work can be implemented using standard logic transistors without being subject to any voltage overstress.
Reaching Human-level Performance in Automatic Grammatical Error Correction: An Empirical Study (2018)

Neural sequence-to-sequence (seq2seq) approaches have proven to be successful in grammatical error correction (GEC). Based on the seq2seq framework, we propose a novel fluency boost learning and inference mechanism. Fluency boosting learning generates diverse error-corrected sentence pairs during training, enabling the error correction model to learn how to improve a sentence's fluency from more instances, while fluency boosting inference allows the model to correct a sentence incrementally with multiple inference steps. Combining fluency boost learning and inference with convolutional seq2seq models, our approach achieves the state-of-the-art performance: 75.72 (F_{0.5}) on CoNLL-2014 10 annotation dataset and 62.42 (GLEU) on JFLEG test set respectively, becoming the first GEC system that reaches human-level performance (72.58 for CoNLL and 62.37 for JFLEG) on both of the benchmarks.
Induction of human cytotoxic T lymphocytes specific for prostate-specific antigen (1997)

Prostate-specific antigen (PSA), a tissue-specific protein expressed by most adenocarcinomas of the prostate, might be a useful target for T-cell-mediated immunotherapy of prostate cancers. The current study examined whether it is possible to elicit human cytotoxic T lymphocytes (CTL) with specificity for PSA. A synthetic nonamer peptide, corresponding to residues 146-154 of PSA and containing a canonical HLA-A2-binding motif, was shown to stabilize the expression of HLA-A2 on the T2 antigen-processing mutant cell line. Repeated in vitro stimulation of peripheral blood lymphocytes from a normal HLA-A2+ donor induced CTL with specificity for the PSA 146-154 peptide. The peptide-induced CTL expressed the CD4- CD8+ cell surface phenotype and were restricted by HLA-A2. A large portion of patients with prostate cancer express the HLA-A2 phenotype, implying that many prostate cancers might be targeted by HLA-A2-restricted CTL with specificity for the PSA 146-154 epitope.