gebhart/patrepeval huggingface dataset:
B-Decachloro-o-carborane Derivatives Suitable for the Preparation of Boron-Labeled Biological Macromolecules (1982)

B-decachloro-o-carborane derivatives in which one of the carbon atoms was substituted by -CH2CH2CO2H (I), -CH2CHOHCH2-O-CH2CH=CH2 (II) and -CH2CHOHCH2-O-p-C6H4NHCOOC(CH3)3 (III) were prepared from decachloro-o-carborane and the corresponding bromo (I) or epoxi (II and III) derivatives under alkaline conditions. II could be epoxidized and bound to dextran, Concanavalin A, and human IgG, with a boron content of 4.3, 4.8, and 4.9% (w/w), respectively. III could be converted to the corresponding amine and further to the isothiocyanate. Such boron derivatives could be suitable compounds for neutron capture therapy of tumors, as they are well water soluble and could be attached to tumor specific antibodies.
Characterization of Transparent Zinc Oxide Films Prepared by Electrochemical Reaction (1997)

Transparent zinc oxide (ZnO) films have been grown by galvanostatic cathodic deposition onto conductive glasses from a simple aqueous zinc nitrate electrolyte maintained at 335 K. The as‐deposited ZnO films were characterized with Fourier transform infrared absorption spectroscopy, x‐ray diffraction, scanning electron microscopy, optical transmission and absorption studies, and measurement of sheet resistivity as a function of cathodic current density. The ZnO films prepared had a wurtzite structure and exhibited an optical bandgap energy of 3.3 eV which is characteristic of ZnO. At a low cathodic current density of , ZnO films with excellent electrical characteristics have been obtained. A 2 μm thick ZnO film with an optical transmittance of 72% was deposited by electrolysis for approximately 20 min at a cathodic current density of .
Audio/video databases: an object-oriented approach (2002)

The notion of an audio/video (AV) database is introduced. An AV database is a collection of AV values such as digital audio and video data and AV activities such as interconnectable components used to process AV values. Two abstraction mechanisms, temporal composition and flow composition, allow the aggregation of AV values and AV activities respectively. An object-oriented framework, incorporating an AV data model and prescribing AV database/application interaction, is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
67-Kilodalton laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas. (1997)

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer.
Applications of computerized adaptive testing (CAT) to the assessment (2003)

Objective: To evaluate the feasibility of computerized adaptive testing (CAT) and the reliability and validity of CAT-based estimates of headache impact scores in comparison with 'static' surveys. Methods: Responses to the 54-item Headache Impact Test (HIT) were re-analyzed for recent headache sufferers (n = 1016) who completed telephone interviews during the National Survey of Headache Impact (NSHI). Item response theory (IRT) calibrations and the computerized dynamic health assessment (DYNHA?) software were used to simulate CAT assessments by selecting the most informative items for each person and estimating impact scores according to pre-set precision standards (CAT-HIT). Results were compared with IRT estimates based on all items (total-HIT), computerized 6-item dynamic estimates (CAT-HIT-6), and a developmental version of a 'static' 6-item form (HIT-6-D). Analyses focused on: respondent burden (survey length and administration time), score distributions ('ceiling' and 'floor' effects), reliability and standard errors, and clinical validity (diagnosis, level of severity). A random sample (n = 245) was re-assessed to test responsiveness. A second study (n = 103) compared actual CAT surveys and an improved 'static' HIT-6 among current headache sufferers sampled on the Internet. Respondents completed measures from the first study and the generic SF-8Tm Health Survey; some (n = 540) were re-tested on the Internet after 2 weeks. Results: In the first study, simulated CAT-HIT and total-HIT scores were highly correlated (r = 0.92) without 'ceiling' or 'floor' effects and with a substantial reduction (90.8%) in respondent burden. Six of the 54 items accounted for the great majority of item administrations (3603/5028, 77.6%). CAT-HIT reliability estimates were very high (0.975-0.992) in the range where 95% of respondents scored, and relative validity (RV) coefficients were high for diagnosis (RV = 0.87) and severity (RV = 0.89); patient-level classifications were accurate 91.3% for a diagnosis of migraine. For all three criteria of change, CAT-HIT scores were more responsive than all other measures. In the second study, estimates of respondent burden, item usage, reliability and clinical validity were replicated. The test-retest reliability of CAT-HIT was 0.79 and alternate forms coefficients ranged from 0.85 to 0.91. All correlations with the generic SF-8 were negative. Conclusions: CAT-based administrations of headache impact items achieved very large reductions in respondent burden without compromising validity for purposes of patient screening or monitoring changes in headache impact over time. IRT models and CAT-based dynamic health assessments warrant testing among patients with other conditions.
Immune stimulatory effects of CD70 override CD70‐mediated immune cell apoptosis in rodent glioma models and confer long‐lasting antiglioma immunity in vivo (2005)

CD70 (CD27 ligand) promotes the expansion of primed lymphocytes by enhancing cell survival. Surprisingly, we previously observed that CD70 aberrantly expressed on human glioma cells promoted immune cell apoptosis and inhibited alloreactive lysis. Here we report that ectopic expression of CD70 in mouse glioma cells enhances apoptosis of T, B and NK cells in coculture, but nevertheless promotes glioma cell lysis by NK cells in vitro. In nude mice, CD70 expression in SMA-560 gliomas delays the glioma growth upon subcutaneous (s.c.) or intracerebral (i.c.) inoculation, suggesting a role for CD70/CD27-dependent NK cell activity in tumor surveillance. In syngeneic immunocompetent VM/Dk mice, CD70 allows the rejection of s.c. and i.c. implanted SMA-560 tumors. The tumorigenicity of CD70-expressing glioma cells is abrogated when TGF-beta signaling is blocked. Moreover, mice surviving the s.c. CD70 glioma challenge subsequently also reject wild-type glioma cells administered i.c. Similarly, CD70-expressing GL-261 gliomas are rejected in syngeneic C57BL/6 mice, while glioma growth is restored in C57BL/6 CD27(-/-) mice, suggesting that the CD70/CD27 interaction recruits a tumor-specific T-cell repertoire and induces tumor-specific memory. Altogether, these observations indicate that the net effect of aberrant CD70 expression in gliomas is immune stimulatory rather than immune paralytic and encourage its application in tumor immunotherapy.
Pulsed Electroreduction of  CO 2 on Copper Electrodes (1993)

Pulsed electroreduction of carbon dioxide was performed on Cu electrodes. The formation rates of reduction products of showed strong contrast between the pulsed method and conventional (galvanostatic) method. Namely, the faradaic efficiencies of and under the pulsed condition kept constant while those under the steady‐state electroreduction reduced drastically as the reduction time passed. This is ascribed to the difference in surface properties of the electrode under the pulsed and steady‐state conditions. It is pointed out that, for a long‐term electroreduction in which the poisoning of the electrode activity due to the deposition of reaction products is likely to take place, the pulsed method is superior to the conventional one.
Fundamentals and Applications of Metasurfaces (2017)

Metasurfaces have become a rapidly growing field of research in recent years due to their exceptional abilities in light manipulation and versatility in ultrathin optical applications. They also significantly benefit from their simplified fabrication process compared to metamaterials and are promising for integration with on‐chip nanophotonic devices owing to their planar profiles. The recent progress in metasurfaces is reviewed and they are classified into six categories according to their underlying physics for realizing full 2π phase manipulation. Starting from multi‐resonance and gap‐plasmon metasurfaces that rely on the geometric effect of plasmonic nanoantennas, Pancharatnam–Berry‐phase metasurfaces, on the other hand, use identical nanoantennas with varying rotation angles. The recent development of Huygens' metasurfaces and all‐dielectric metasurfaces especially benefit from highly efficient transmission applications. An overview of state‐of‐the‐art fabrication technologies is introduced, ranging from the commonly used processes such as electron beam and focused‐ion‐beam lithography to some emerging techniques, such as self‐assembly and nanoimprint lithography. A variety of functional materials incorporated to reconfigurable or tunable metasurfaces is also presented. Finally, a few of the current intriguing metasurface‐based applications are discussed, and opinions on future prospects are provided.
Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis (2010)

We demonstrate that the cannabinoid receptor CB1 is crucial for leukocyte infiltration and secondary fibroblast activation and that inactivation of CB1 exerts potent antifibrotic effects in inflammation-driven models of fibrosis.
Resolving occlusion in augmented reality (1995)

Current state-of-the-art augmented reality systems simply overlay computer-generated visuals on the real-world imagery, for example via video or optical see-through displays. However, overlays are not effective when displaying data in three dimensions, since occlusion between the real and computer-generated objects is not addressed.
Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer (2015)

Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in vitro, but it is rapidly lost in standard 2D cultures. Unexpectedly, physiological induction of endogenous HSATII RNA, as well as introduction of synthetic HSATII transcripts, generated cDNA intermediates in the form of DNA/RNA hybrids. Single molecule sequencing of tumor xenografts showed that HSATII RNA-derived DNA (rdDNA) molecules are stably incorporated within pericentromeric loci. Suppression of RT activity using small molecule inhibitors reduced HSATII copy gain. Analysis of whole-genome sequencing data revealed that HSATII copy number gain is a common feature in primary human colon tumors and is associated with a lower overall survival. Together, our observations suggest that cancer-associated derepression of specific repetitive sequences can promote their RNA-driven genomic expansion, with potential implications on pericentromeric architecture.
The effect of jamming on the performance of carrier interferometry/OFDM (2006)

This paper analyzes the performance of carrier interferometry/orthogonal frequency division multiplexing (CI/OFDM) in the presence of multipath fading as well as jamming. Specifically, the effect of jamming power and jammer bandwidth on the performance of CI/OFDM and OFDM is investigated. While CI/OFDM significantly outperforms traditional OFDM in a fading environment, we demonstrate that OFDM is more resistant to single-tone jamming than CI/OFDM. Furthermore, OFDM is more robust when jamming power increases although CI/OFDM is more robust when the bandwidth of the jammer increases. We also show that by employing frequency-domain anti-jamming techniques, it is possible to restore the performance gains offered by CI/OFDM relative to traditional OFDM.
Large-Scale Sources of Neural Stem Cells (2002)

Large-scale sources of neural stem cells are crucial for both basic research and novel approaches toward treating neurological disorders. Three sources that produce neural cells closely resembling their normal counterparts are now available: oncogene immortalized stem cells, neurospheres, and embryonic stem cell (ES)-derived neural cells. Cells including multiple subtypes of CNS and PNS neurons, as well as oligodendrocytes, Schwann cells, and astrocytes, are modeled by these large-scale sources. Although most cell lines were originally from rodents, their human counterparts are being discovered and characterized.
Cloning of a cDNA for a Second Retinol Dehydrogenase Type II (1995)

A retinol dehydrogenase, RoDH(1), which recognizes holo-cellular retinol-binding protein (CRBP) as substrate, has been cloned, expressed, and identified as a short-chain dehydrogenase/reductase (Chai, X., Boerman, M. H. E. M., Zhai, Y., and Napoli, J. L. (1995) J. Biol. Chem. 270, 3900-3904). This work reports the cloning and expression of a cDNA encoding a RoDH isozyme, RoDH(II). The predicted amino acid sequence verifies RoDH(II) as a short-chain dehydrogenase/reductase, 82% identical with RoDH(I). RoDH(II) recognized the physiological form of retinol as substrate, CRBP, with a Km of 2 mM. Similar to microsomal RoDH and RoDH(I), RoDH(II) had higher activity with NADP rather than NAD, was stimulated by ethanol and phosphatidyl choline, was not inhibited by the medium-chain alcohol dehydrogenase inhibitor 4-methylpyrazole, but was inhibited by phenylarsine oxide and the short-chain dehydrogenase/reductase inhibitor carbenoxolone. Northern blot analysis detected RoDH(I) and RoDH(II) mRNA only in rat liver, but RNase protection assays revealed RoDH(I) and RoHD(II) mRNA in kidney, lung, testis, and brain. These data indicate that short-chain dehydrogenases/reductase isozymes expressed tissue-distinctively catalyze the first step of retinoic acid biogenesis from the physiologically most abundant substrate, CRBP.
Synthesis and Ordered Phase Separation of Imidazolium-Based Alkyl–Ionic Diblock Copolymers Made via ROMP (2011)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSynthesis and Ordered Phase Separation of Imidazolium-Based Alkyl–Ionic Diblock Copolymers Made via ROMPErin F. Wiesenauer†, Julian P. Edwards†, Vincent F. Scalfani‡, Travis S. Bailey*‡, and Douglas L. Gin*†View Author Information† Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, United States‡ Department of Chemical and Biological Engineering and Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1370, United StatesE-mail: [email protected] (D.L.G.); [email protected] (T.S.B.).Cite this: Macromolecules 2011, 44, 13, 5075–5078Publication Date (Web):June 15, 2011Publication History Received26 January 2011Revised1 June 2011Published online15 June 2011Published inissue 12 July 2011https://pubs.acs.org/doi/10.1021/ma200184uhttps://doi.org/10.1021/ma200184urapid-communicationACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views2224Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymers,Homopolymers,Imidazolium,Monomers,Polymers Get e-Alerts
Generation and synthetic utility of dianions derived from thiophencarboxylic acids (1983)

Thiophen-2- and -3-carboxylic acid are rapidly and regioselectively metallated by lithium di-isopropy liamide in tetrahydrofuran at –78 °C. The resulting dianionic species [(10) and (4), respectively] react with a range of electrophiles to give the expected thiophencarboxylic acid homologues in good-to-excellent yields.
Glycosidopyrroles. part 4. 1-β-D-ribofuranosyl-pyrroles and indoles as potential antiviral agents (2000)

The preparation of new 1--D-ribofuranosylpyrroles of type 8 and a new method of synthesis of 1--D-ribofuranosylindoles of type 10, according to the scheme, is reported. All these new derivatives showed promising chemical and physical analogies with bioactive molecules but did not show any antiviral activity againstHIV1.
Novel indole-2-carboxylic acid analogues: Synthesis and a new light in to their antioxidant potentials (2012)

Two series of novel indole-2-carboxylic acid derivatives is reported. In the first series, N-substituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1H NMR and mass data and were screened for antioxidant activity. Among the first series, compound 3g showed higher antioxidant activity and whereas, in the second series compounds 5b and 5c exhibited potential antioxidant activity. Compounds 3g, 5b and 5c exhibited for its enhanced antioxidant activity.
Prolonged Correction of Hyperlipidemia in Mice with Familial Hypercholesterolemia Using an Adeno-Associated Viral Vector Expressing Very-Low-Density Lipoprotein Receptor (2000)

Adeno-associated viral vectors were used to deliver the gene for very-low-density lipoprotein (VLDL) receptor (VLDLR) to liver of a murine model of familial hypercholesterolemia (FH). Infusion of adeno-associated virus-VLDLR into the portal circulation of FH mice resulted in a 40% reduction in serum cholesterol and triglyceride that was stable for the duration of the study (30 weeks). Fractionation of serum lipids revealed a reduction of both VLDL and low-density lipoprotein. Expression of transgene-derived VLDLR was confirmed in livers of recipient animals by Western blot analysis and immunohistochemistry; vector DNA was present at 1 copy/cell. Vector-treated animals had significantly less lipid accumulation in liver and reduced atherosclerosis in the aorta.
Evolution of the Protein Corona of Lipid Gene Vectors as a Function of Plasma Concentration (2011)

The concept that the effective unit of interest in the cell-nanomaterial interaction is the particle and its corona of associated proteins is emerging. Here we investigate the compositional evolution of the protein corona of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) cationic liposomes (CLs) and DOTAP/DNA lipoplexes over a wide range of plasma concentrations (2.5-80%). The composition of the hard corona of lipoplexes is quite stable, but that of CLs does evolve considerably. We show that the protein corona of CLs is made of both low-affinity and competitive-binding proteins whose relative abundance changes with the plasma concentration. This result may have deep biological implications for the application of lipid-based gene vectors both in vitro and in vivo.
Host-guest complexation. 52. Bridged and chiral hemispherands (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest complexation. 52. Bridged and chiral hemispherandsJohn A. Tucker, Carolyn B. Knobler, Israel Goldberg, and Donald J. CramCite this: J. Org. Chem. 1989, 54, 23, 5460–5482Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/jo00284a018https://doi.org/10.1021/jo00284a018research-articleACS PublicationsRequest reuse permissionsArticle Views330Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-Purity Separation of Gold Nanoparticle Dimers and Trimers (2009)

An effective method was developed for separating gold-nanoparticle clusters in high resolution; dimer and trimer samples were obtained with 95% and 81% purity, respectively.