gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Products and Mechanisms of the Gas‐Phase Reactions Between NO3 and a Series of Alkenes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Model-based analysis of hand posture (1995)

Researchers have successfully recognized specific fingers of the hand by silhouette images and distinguished a small set of hand signs by contour features of images. However, the silhouette or contour features recovered from the images do not provide sufficient information to generate a 3D hand posture with the fingers positioned properly. This failure led to our study, which developed a new method employing a hand model that can automatically analyze 3D hand postures using static stereo images. Guided by internal constraints and external forces, the model is automatically fitted to the hand image. Our method differs from previous methods in that it captures 27 interacting hand parameters, including finger joint angles, enabling suitable reconstruction of 3D hand posture.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Commercial Production of Radioisotopes for Nuclear Medicine, 1970-1980 (1981)

The first small cyclotrons were installed for commercial production of radioisotopes at New England Nuclear Corporation, Billerica, Massachusetts, and at Medi-Physics, Emeryville, California. Both machines were Cyclotron Corporation Cs-22 multiple particle, fixed energy cyclotrons. In the ten years that followed, the total number of commercial radioisotope producing small accelerators has grown to ten, with four more projected for 1981. The beam energy requirement for the first accelerators was modest; 22 MeV protons, 12 MeV deuterons, 24 MeV He-4, and 31 MeV He-3; and commercial radioisotope production for nuclear medicine utilized all four particles. The first product available from cyclotron production was fluorine-18 from the 16O(3He, p)18F reaction. Injected intravenously as no-carrier-added Na18F, the radionuclide quickly concentrated in bone, providing the nuclear medicine physician with diagnostic information on skeletal abnormalities including metastatic bone disease. Following in quick succession were 67Ga from 68Zn(p, 2n)67Ga, 111In from 112Cd(p, 2n)111In, 43K from 40Ar(α, p)43K, 123I from 122Te(d, n)123I, and 81Rb from 82Kr(p, 2n)81Rb. The next few years saw one radionuclide, 43K, disappear from the marketplace, and two others, 18F and 81Rb, disappear, and then reappear, although not for the purposes originally intended. More recently, the widespread demand for 201Tl for imaging myocardial perfusion has led to increased requirements for beam energies higher than those from the original small cyclotrons.
Topically Applied AaeIAP1 Double-Stranded RNA Kills Female Adults of Aedes aegypti (2008)

Aedes aegypti (L.) (Diptera: Culicidae) is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti (AaeIAP1) was targeted for the development of molecular pesticides. Herein, for the rst time, we report that topically applied AaeIAP1 double-stranded RNA products are able to kill female adults of Ae. aegypti. Our results indicate that critical pathways or genes could be targeted to develop molecular pesticides for the control of medically important diseases vectors.
Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon (1998)

Transplantation of human amniotic membrane with a limbal autograft appears to be a promising surgical treatment for reconstructing the ocular surface in patients with recurrent pterygium associated with symblepharon.
L-Lactic Acid: A Mosquito Attractant Isolated from Humans (1968)

L-Lactic acid was the major component in material isolated from humans that was active as an attractant for female yellow fever mosquitoes, Aedes aegypti (L.). The L(+)-isomer was several times as attractive as the D-isomer. Good correlation was found between the attractiveness of an individual to mosquitoes and the quantity of lactic acid present in an acetone washing of his hand.
Fundamental Contribution of β-Oxidation to Polyketide Mycotoxin Production In Planta (2005)

Seed contamination with polyketide mycotoxins, including aflatoxin (AF) and sterigmatocystin (ST) produced by Aspergillus spp., is an agricultural, economic, and medical issue worldwide. Acetyl-CoA, the fundamental building block of all known fungal polyketides, is generated by a large number of biochemical pathways, including beta-oxidation of fatty acids and glycolysis of sugars. We present several lines of evidence to support a major role for seed fatty acids in formation of AF and ST in A. flavus, A. parasiticus, and A. nidulans. Aspergillus strains exhibiting canonical signs of oleic acid-induced peroxisome proliferation, including increased catalase activity, beta-oxidation gene expression, and peroxisomal clustering, also exhibited a marked increase in toxin gene expression and biosynthesis. Furthermore, microscopic observations showed that the ST and AF precursor norsolorinic acid accumulated in peroxisomes of all three Aspergilli. While a peroxisomal beta-oxidation mutation eliminated oleic acid-induced increases in ST in A. nidulans, a mitochondrial beta-oxidation mutation played a larger role in eliminating ST formation on oatmeal medium and on live corn kernels, implicating a fundamental role for both peroxisomal and mitochondrial beta-oxidation in toxin production.
Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains (2001)

We used integrin alphaLbeta2 heterodimers containing I domains locked open (active) or closed (inactive) with disulfide bonds to investigate regulatory interactions among domains in integrins. mAbs to the alphaL I domain and beta2 I-like domain inhibit adhesion of wild-type alphaLbeta2 to intercellular adhesion molecule-1. However, with alphaLbeta2 containing a locked open I domain, mAbs to the I domain were subdivided into subsets (i) that did not inhibit, and thus appear to inhibit by favoring the closed conformation, and (ii) that did inhibit, and thus appear to bind to the ligand binding site. Furthermore, alphaLbeta2 containing a locked open I domain was completely resistant to inhibition by mAbs to the beta2 I-like domain, but became fully susceptible to inhibition after disulfide reduction with DTT. This finding suggests that the I-like domain indirectly contributes to ligand binding by regulating opening of the I domain in wild-type alphaLbeta2. Conversely, locking the I domain closed partially restrained conformational change of the I-like domain by Mn(2+), as measured with mAb m24, which we map here to the beta2 I-like domain. By contrast, locking the I domain closed or open did not affect constitutive or Mn(2+)-induced exposure of the KIM127 epitope in the beta2 stalk region. Furthermore, locked open I domains, in alphaLbeta2 complexes or expressed in isolation on the cell surface, bound to intercellular adhesion molecule-1 equivalently in Mg(2+) and Mn(2+). These results suggest that Mn(2+) activates alphaLbeta2 by binding to a site other than the I domain, most likely the I-like domain of beta2.
The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein (1997)

cpts530, a candidate live-virus vaccine, is an attenuated strain of human respiratory syncytial virus (RSV). It was derived by subjecting a cold-passaged (cp) strain of RSV to a single round of chemical mutagenesis. cpts530 is a temperature-sensitive (ts) mutant that is attenuated in mice and chimpanzees, and its ts phenotype exhibits a high level of stability during replication in both species. In the present study, the complete nucleotide sequence of cpts530 RSV was determined. The five mutations known to be present in the parent cpRSV were retained in its cpts530 derivative, and one additional nucleotide change was identified at nucleotide (nt) 10060, which resulted in a phenylalanine-to-leucine change at amino acid 521 in the large polymerase (L) protein. To determine if this single amino acid substitution was indeed responsible for the ts phenotype of cpts530, it was introduced alone or in combination with the cp mutations into the full-length cDNA clone of the wild-type A2 RSV. Analysis of infectious viruses recovered from mutant cDNAs indicated that this single mutation specified complete restriction of plaque formation of recombinant cp530 in HEp-2 cell monolayer cultures at 40 degrees C, and the level of temperature sensitivity was not influenced by the presence of the five cpRSV mutations. These findings identify the phenylalanine-to-leucine change at amino acid 521 in the L protein as the mutation that specifies the ts phenotype of cpts530. Furthermore, these findings illustrate the feasibility of using the cDNA-based recovery system to analyze and construct defined attenuated vaccine viruses.
The IBM System/370 vector architecture: design considerations (1988)

The considerations that shaped the architecture of the IBM System/370 Vector Facility are reviewed. The architectural requirements, decisions, and innovations are summarized, and the rationale for the choices that were made is given. Issues related to vector function, performance, compatibility, migration, and integration with the rest of the System/370 architecture are covered.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Microarrays of Synthetic Heparin Oligosaccharides (2006)

We present the first preparation of microarrays containing synthetic heparin oligosaccharides in order to elucidate the heparin-protein interactions involved in a variety of biological processes. For this purpose, we have developed a novel linker strategy that is compatible with the protecting-group manipulations required for the synthesis of the highly sulfated oligosaccharides and can also be extended to an automated solid phase approach. Strategic placement of the orthogonally protected amine linker was key to the success of the array construction. These heparin chips allow for the high-throughput screening of oligosaccharides by using approximately picomoles of protein. The potential of the new method was demonstrated by probing the carbohydrate affinity of two heparin-binding growth factors, FGF-1 and FGF-2, that are implicated in the development and differentiation of several tumors.
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish (2005)

Tube and lumen formation are essential steps in forming a functional vasculature. Despite their significance, our understanding of these processes remains limited, especially at the cellular and molecular levels. In this study, we analyze mechanisms of angioblast coalescence in the zebrafish embryonic midline and subsequent vascular tube formation. To facilitate these studies, we generated a transgenic line where EGFP expression is controlled by the zebrafish flk1 promoter. We find that angioblasts migrate as individual cells to form a vascular cord at the midline. This transient structure is stabilized by endothelial cell-cell junctions, and subsequently undergoes lumen formation to form a fully patent vessel. Downregulating the VEGF signaling pathway, while affecting the number of angioblasts, does not appear to affect their migratory behavior. Our studies also indicate that the endoderm, a tissue previously implicated in vascular development, provides a substratum for endothelial cell migration and is involved in regulating the timing of this process, but that it is not essential for the direction of migration. In addition, the endothelial cells in endodermless embryos form properly lumenized vessels, contrary to what has been previously reported in Xenopus and avian embryos. These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish.
Rietveld refinement of Debye–Scherrer synchrotron X-ray data from Al2O3 (1987)

The application of the Rietveld refinement technique to synchrotron X-ray data collected from a capillary sample of Al2O3 in Debye–Scherrer geometry is described. The data were obtained at the Cornell High Energy Synchrotron Source (CHESS) with an Si(111) double-crystal monochromator and a Ge(111) crystal analyzer. Fits to a number of well resolved individual peaks demonstrate that the peak shapes are very well described by the pseudo-Voigt function, which is a simple approximation to the convolution of Gaussian and Lorentzian functions. The variation of the Gaussian and Lorentzian half widths, ΓG and ΓL, with Bragg angle can be approximated quite closely by the functions V tan θ and X/cos θ which represent the contributions from instrumental resolution and particle-size broadening respectively. Rietveld refinement based on this model yields generally satisfactory results. The refined values of V and X are consistent with the expected vertical divergence (≃0.1 mrad) and the nominal particle size (≃ 0.3μm). In particular, the use of a capillary specimen virtually eliminates preferred orientation effects, which are highly significant in flat-plate samples of this material.
Energy efficiency optimization in green wireless communications (2013)

The neurofibromatoses are inherited, tumor suppressor disorders that are characterized by multiple, benign peripheral nerve sheath tumors and other nervous system tumors. Each disease is associated with a distinct genetic mutation and with a different pathogenesis and clinical course. Neurofibromatosis 1 (NF1) is common and epitomized by multiple neurofibromas with widespread complications. NF2 and schwannomatosis are rare diseases that are typified by multiple schwannomas that are particularly painful in people with schwannomatosis. Since 1985, the Children's Tumor Foundation (formerly the National Neurofibromatosis Foundation) has hosted an international Neurofibromatosis Conference, bringing together international participants who are focused on NF research and clinical care. The 2017 Conference, held in Washington, DC, was among the largest gatherings of NF researchers to date and included presentations from clinicians and basic scientists, highlighting new data regarding the molecular and cellular mechanisms underlying each of these diseases as well as results from clinical studies and clinical trials. This article summarizes the findings presented at the meeting and represents the current state-of-the art for NF research.
Characterization of intracellular and extracellular vaccinia virus variants: N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine interferes with cytoplasmic virus dissemination and release (1981)

Infectious vaccinia virus can be purified from whole cells by experimentally induced lysis (intracellular virus) or from supernatant growth medium (extracellular virus). Extracellular virus and intracellular virus differed by buoyant density (1.237 versus 1.272 g/cm3), phospholipid content and composition, and polypeptide pattern. Differences in structural polypeptides on the virus surface could be detected by lactoperoxidase-catalyzed radioiodination or Brij treatment. Characteristic of extracellular virus was an additional polypeptide, with a molecular weight of 37,000 (37K), which represented 5 to 7% of the total particle protein. Antibodies to the 37K protein detected only some of the cell-associated particles late in normal infection. Upon treatment of infected cultures with N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine, a drug which prevents vaccinia virus release, no particle-associated 37K protein could be detected. In all other properties tested so far, except for a slight difference in phospholipid composition, the virus obtained in the presence of the drug resembled the normal intracellular virus. N1-Isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine prevented vesicularization of intracellular viral particles. Lack of vesicularization was accompanied by the absence of particle-associated 37K viral protein and seemed to correlate with an inhibition of virus dissemination to the cell periphery.
Behavioral and magnetoencephalographic correlates of plasticity in the adult human brain (1993)

Recent behavioral and physiological evidence suggests that even brief sensory deprivation can lead to the rapid emergence of new and functionally effective neural connections in the adult human brain.
Oxaliplatin-Associated Neuropathy: A Review (2004)

Peripheral neuropathy is seen in the majority of patients who receive oxaliplatin. The acute form is usually transient and self-limited; however, the chronic form can be dose-limiting. Calcium and magnesium solutions are an effective and convenient means of treating and reducing the severity of neuropathic symptoms. Additional studies, including controlled trials, are needed to determine the best way to prevent and treat this complication.
Properties of blends of starch and synthetic polymers containing anhydride groups (1994)

Abstract Corn starch was blended with styrene maleic anhydride copolymer (SMA), ethylene‐propylene‐ g ‐maleic anhydride copolymer (EPMA), and corresponding nonfunctional polystyrene and ethylene propylene copolymers. The concentration of starch in the blend was varied between 50 and 80% by weight. The torque generated during blending is reported increasing starch content for starch/SMA blends: the reverse was true for starch/EPMA blends. The torque was higher for the blends of the anhydride functional polymers compared to the blends of corresponding nonfunctional polymers. Water absorption of the blends increased with an increase in the starch content. Starch/SMA blends made at higher mixer speed or time were more water sensitive. Blends containing EPMA absorbed less water than SMA blends containing the same weight fraction of starch. Tensile strengths of blends containing functional groups were superior compared to the blends made from nonfunctional polymers. When the starch contents increased from 60 to 70%, the tensile strength remained unchanged for SMA blend but increased for EPMA blend. All samples supported the growth of microorganisms, which increased with increasing starch content. © 1994 John Wiley &amp; Sons, Inc.
Nasal-nanotechnology: revolution for efficient therapeutics delivery (2014)

The use of nanomaterials including peptide-based nanotubes and nanogels (NGs) for vaccine delivery via nasal route is a new approach to control the disease progression. In this review, the recent developments in nanotechnology utilized for nasal drug delivery have been discussed.
Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase‐1, C/EBP‐β and ILAD‐1, a novel gene with homology to arrestins (2004)

We recently demonstrated that the potent hallucinogenic drug lysergic acid diethylamide (LSD) dynamically influences the expression of a small collection of genes within the mammalian prefrontal cortex. Towards generating a greater understanding of the molecular genetic effects of hallucinogens and how they may relate to alterations in behavior, we have identified and characterized expression patterns of a new collection of three genes increased in expression by acute LSD administration. These genes were identified through additional screens of Affymetrix DNA microarrays and examined in experiments to assess dose-response, time course and the receptor mediating the expression changes. The first induced gene, C/EBP-beta, is a transcription factor. The second gene, MKP-1, suggests that LSD activates the MAP (mitogen activated protein) kinase pathway. The third gene, ILAD-1, demonstrates sequence similarity to the arrestins. The increase in expression of each gene was partially mediated through LSD interactions at 5-HT2A (serotonin) receptors. There is evidence of alternative splicing at the ILAD-1 locus. Furthermore, data suggests that various splice isoforms of ILAD-1 respond differently at the transcriptional level to LSD. The genes thus far found to be responsive to LSD are beginning to give a more complete picture of the complex intracellular events initiated by hallucinogens.
Appearance based Techniques for Face Recognition: A Comparative Study (2014)

In these days, appearance based approaches gain popularity in many computer vision problems, more in particular on face recognition techniques. In this context, a study on face recognition techniques based on appearance based paradigm is addressed in our work. More focus is provided to principal component analysis (PCA) based techniques where the principle of PCA is well received by pattern recognition community for most of the dimensionality reduction problems or for feature selection in a large collection of features set. We have seen several variants of PCA in the literature applied to the domain of face recognition considering variety of natural problems that would occur during face recognition. In our work, we have made an attempt to study the problem of face recognition under different situations. The study is conducted with varying dimension of features on a variety of face databases which include pose, illumination and occlusion problems. The effect of varying training samples is also addressed in our study. We have considered the standard PCA, two dimensional PCA (2D PCA) which works in row directions, alternative 2D PCA that works in column directions and bidirectional PCA for comparative analysis on many of the standard face databases such as AT&amp;amp;T, UMIST and IITK datasets. Extensive experimental results on each of these datasets along with computing time and their recognition accuracy under different dimension of feature vectors with varying number of training samples is reported in our work.