gebhart/patrepeval huggingface dataset:
Phosphorylation by means of cyclic enediol phosphates (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphorylation by means of cyclic enediol phosphatesFausto Ramirez and James F. MarecekCite this: Acc. Chem. Res. 1978, 11, 6, 239–245Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ar50126a003https://doi.org/10.1021/ar50126a003research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Study of Vector Boson Scattering and Search for New Physics in Events with Two Same-Sign Leptons and Two Jets (2015)

A study of vector boson scattering in pp collisions at a center-of-mass energy of 8 TeV is presented. The data sample corresponds to an integrated luminosity of 19.4 fb(-1) collected with the CMS detector. Candidate events are selected with exactly two leptons of the same charge, two jets with large rapidity separation and high dijet mass, and moderate missing transverse energy. The signal region is expected to be dominated by electroweak same-sign W-boson pair production. The observation agrees with the standard model prediction. The observed significance is 2.0 standard deviations, where a significance of 3.1 standard deviations is expected based on the standard model. Cross section measurements for W(±)W(±) and WZ processes in the fiducial region are reported. Bounds on the structure of quartic vector-boson interactions are given in the framework of dimension-eight effective field theory operators, as well as limits on the production of doubly charged Higgs bosons.
SOA Meets Robots - A Service-Based Software Infrastructure for Remote Laboratories (2008)

With the ongoing internationalization of virtual laboratories, the integration aspect becomes more important. The meanwhile commonly accepted â??glueâ?? for such legacy systems are service oriented architectures, based on standardized and accepted Web service standards. We present our concept of the â??experiment as a serviceâ??, where the idea of service-based architectures is applied to virtual remote laboratories. In our laboratory middleware, experiments are represented as stateful service implementations and jobs as logical service instances of these implementations. We discuss performance, reliability, security and monitoring issues in this approach, and show how the resulting infrastructure - the Distributed Control Lab - is applied in the European VetTrend project.
Selective protection of the primary hydroxyl groups of oxetanocin A and conformational analysis of O-protected oxetanocin A. (1995)

One of the two primary hydroxyl groups of oxetanocin A was protected selectively with acetyl and o-nitrobenzyl groups using enzymatic and photochemical reactions, respectively. On the basis of 1H-NMR spectroscopy and NOE experiment, 4'-O-protected oxetanocin A was found to take syn conformation in an aprotic solvent irrespective of the kind of protecting group owing to an intramolecular hydrogen bond.
The genetic basis of xeroderma pigmentosum. (1991)

The chemical integrity and proper functioning of DNA is threatened by numerous chemical and physical agents that cause a wide spectrum of DNA lesions. When unrepaired, DNA injury interferes with vital, cellular functions such as DNA replication and transcription and give rise to mutations leading to genetic defects, carcinogenesis and cell death. The contribution of DNA repair systems in preventing cancer is apparent from the high rate of tumorigenesis found in many repair syndromes. A classical example is the excision repair disorder xeroderma pigmentosum (XP) in which patients exhibit hypersensitivity to sun (UV) light and predisposition to skin cancer. Genetic analysis of cultured cells from XP patients has revealed the presence of at least 7 complementation groups, all showing a deficiency in the excision of UV-induced lesions in the DNA. To identify the genes and characterize the genetic defects in these complementation groups, cloning of human DNA repair genes has been attempted by a number of investigators. Recently, the first human DNA repair genes have been cloned including at least two genes involved in XP. Comparison of the coding sequences of these genes with sequences of cloned (repair) genes of lower organisms (e.g. E. coli and yeast) provides information on their function. This leads to understanding of the relationship between molecular defect at the level of the gene and the gene product and the clinical manifestation of the disease in different XP patients and complementation groups.
Overcoming the Taste Stigma of Soy (2003)

ABSTRACT: Can labels unknowingly influence a person's taste perceptions? Using a “phantom ingredient” taste test, the presence or absence of a labeled ingredient (soy) was shown to influence sensory evaluations of a food. In particular, a nutrition bar wrongly purporting to contain soy generated negative ratings of taste, aftertaste, and attitude, yet generated favorable ratings of its nutritiousness. Because there was actually no soy in the product, these differences represent biases caused by ingredient labeling. Given the appropriate segment of consumers (health‐oriented), ingredient labeling may have more favorable consequences. This power of suggestion might also be expanded to other ingredients or processes, such as those involving biotechnology or organic production.
Thermal modeling of lesion growth with radiofrequency ablation devices (2004)

When modeling radiofrequency ablation problems, temperature isotherms may not be representative of actual tissue damage patterns.
A New and Very Real Nursing Shortage (2001)

Current demographics of the nursing shortage are presented and discussed. Issues of this particular nursing crisis are explored relative to past nursing shortages. State and organizational responses to the current crisis are listed relative to the following key areas of nursing concern: mandatory overtime, whistleblower protection, reporting of nursing-sensitive quality data, and patient classification systems.
预控法—一种代替X—R控制图的好方法 (1992)

近几年来,在美国人们对X—R控制图再次发生兴趣.这种兴趣的出现,是与人们对美国产品质量与日俱增的担忧,以及探索经济有效的提高产品质量的途径相关联的.为迅速适应这种趋势,美国的一些质量管理工程师开始在他们的公司内广泛地设置了大量的X—R控制图. X—R控制图,如能正确运用,就能成为工序控制的一种非常有效的工具.但在很多情况下,特别是在使用现场中,它的缺点比它的优点更显得突出.X—R控制图要求生产人员或检查人员记录数据、计算X和R,并在图上打点.有些人还得收集控制图,重新计算控制界限,更换控制图等.加工周期短的工序,常常还未计算好控制界限,而其加工过程却已经完成.还有许多应用场合,操作者在其加工过
Diabetic Nephropathy: Where Hemodynamics Meets Metabolism (2007)

Diabetic nephropathy (DN), the most common cause of end stage renal disease in developed nations, is thought to result from interactions between metabolic and haemodynamic factors. Specific metabolically driven, glucose dependent pathways are activated within diabetic renal tissues. These pathways induce oxidative stress, polyol pathway flux, hexosamine flux and accumulation of advanced glycated end-products (AGEs). Haemodynamic factors are also implicated in the pathogenesis of DN and include elevations of systemic and intraglomerular pressure and activation of various vasoactive hormone pathways including the renin-angiotensin aldosterone system (RAAS), endothelin and urotensin. These altered hemodynamics act independently and in concert with metabolic pathways, to activate intracellular second messengers such as protein kinase C (PKC) and MAP kinase (MAPK), nuclear transcription factors such as nuclear factor-κB (NF-κB) and various growth factors such as the prosclerotic cytokines, transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF) and the angiogenic, permeability enhancing growth factor, vascular endothelial growth factor, VEGF. Ultimately these molecular mechanisms lead to increased renal albumin permeability, and extracellular matrix accumulation, which results in increasing proteinuria, glomerulosclerosis and tubulointerstitial fibrosis.In the past, the treatment of diabetic nephropathy has focused on control of hyperglycemia and the interruption of the RAAS with certain anti-hypertensive agents. Newer novel targets, some of which are linked to glucose dependent pathways, appear to be a major focus of new therapies directed against the development and progression of renal damage as a result of diabetes. It is likely that resolution of diabetic nephropathy will require synergistic therapies to target multiple mediators of this disease.
Piperazinealkanol Ester Derivatives of Indomethacin as Dual Inhibitors of 5-Lipoxygenase and Cyclooxygenase. (1994)

Piperazinealkanol ester derivatives of indomethacin were prepared and tested for inhibitory activities against 5-lipoxygenase (5-LO) and cyclooxygenase (CO). They inhibited 5-hydroxyeicosatetraenoic acid (5-HETE) formation by the cytosol of guinea pig polymorphonuclear leukocytes and thromboxane B2 (TXB2) formation by washed rabbit platelet suspension. Of the test compounds, 2-[4-(2-hydroxyethyl)-1-piperazinyl]-1-phenylethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate dimaleate (II-8) was found to be the most active dual inhibitor of 5-LO and CO, and its inhibitory potency was higher than that of 2-[4-(3-hydroxypropyl)-1-piperazinyl]-ethyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl]-3-indolyacetate (CR-1015) (I), the lead compound.
Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers (2007)

Botulism is mainly acquired by the oral route, and botulinum neurotoxin (BoNT) escapes the gastrointestinal tract by crossing the digestive epithelial barrier prior to gaining access to the nerve endings. Here, we show that biologically active BoNT/A crosses intestinal cell monolayers via a receptor-mediated transcytosis, including a transport inhibition at 4 degrees C and a passage at 37 degrees C in a saturable manner within 30-60 min. BoNT/A passage rate was about 10-fold more efficient through the intestinal crypt cell line m-IC(cl2), than through the carcinoma Caco-2 or T84 cells, and was not increased when BoNT/A was associated with the non-toxic proteins (botulinum complex). Like for neuronal cells, BoNT/A binding to intestinal cells was mediated by the half C-terminal domain as tested by fluorescence-activated cytometry and by transcytosis competition assay. A 'double receptor model' has been proposed in which BoNT/A interacts with gangliosides of GD(1b) and GT(1b) series as well as SV2 protein. Gangliosides of GD(1b) and GT(1b) series and recombinant intravesicular SV2-C domain partially impaired BoNT/A transcytosis, suggesting a putative role of gangliosides and SV2 or a related protein in BoNT/A transcytosis through Caco-2 and m-IC(cl2) cells.
Rapid differentiation and enumeration of the total, viable vegetative cell and spore content of thermophilic bacilli in milk powders with reference to Anoxybacillus flavithermus (2005)

The current study provides a tool to monitor the extent of thermophilic contamination during milk powder manufacturing 60-90 min after sampling.
Electrocatalytic Reduction of Carbon Dioxide by Mn(CN)(2,2′-bipyridine)(CO)3: CN Coordination Alters Mechanism (2015)

MnBr(2,2'-bipyridine)(CO)3 is an efficient and selective electrocatalyst for the conversion of CO2 to CO. Herein, substitution of the axial bromide for a pseudohalogen (CN) is investigated, yielding Mn(CN)(2,2'-bipyridine)(CO)3. This replacement shifts the first and second reductions to more negative potentials (-1.94 and -2.51 V vs Fc/Fc(+), respectively), but imparts quasi-reversibility at the first feature. The two-electron, two-proton reduction of CO2 to CO and H2O is observed at the potential of the first reduction. Data from IR spectroelectrochemistry, cyclic voltammetry, and controlled potential electrolysis indicate that this behavior arises from the disproportionation of two one-electron-reduced species to generate the catalytically active species. Computations using density functional theory are also presented in support of this new mechanism.
Elevated Factor XI Activity Levels Are Associated With an Increased Odds Ratio for Cerebrovascular Events (2006)

High levels of factor XI have been implicated as a risk factor for deep venous thrombosis and possibly cardiovascular disease; however, the relationship between elevated factor XI activity and stroke has yet to be established. We retrospectively evaluated factor XI activity, factor XI antigen, and high-sensitivity C-reactive protein (hs-CRP) values in samples from 65 patients with stroke, 13 with transient ischemic attack (TIA), and 17 with venous thrombosis, younger than 55 years with normal prothrombin and partial thromboplastin times who underwent evaluation for a hypercoagulable state. Factor XI activity levels were more than normal in 22% of patients with stroke or TIA and 18% of patients with venous thrombosis, producing odds ratios of 5.3 and 4.1 for stroke or TIA and venous thrombosis, respectively. Factor XI activity levels correlate with factor XI antigen levels by Deming regression analysis (slope, 1.3; R = 0.667) and a lack of correlation of both with hs-CRP suggests that factor XI is not an acute phase reactant. Our findings suggest an association between elevated factor XI activity and stroke.
Preterminal host dendritic cells in irradiated mice prime CD8+ T cell–mediated acute graft-versus-host disease (2002)

To understand the relationship between host antigen-presenting cells (APCs) and donor T cells in initiating graft-versus-host disease (GVHD), we followed the fate of host dendritic cells (DCs) in irradiated C57BL/6 (B6) recipient mice and the interaction of these cells with minor histocompatibility antigen- (miHA-) mismatched CD8+ T cells from C3H.SW donors. Host CD11c+ DCs were rapidly activated and aggregated in the T cell areas of the spleen within 6 hours of lethal irradiation. By 5 days after irradiation, <1% of host DCs were detectable, but the activated donor CD8+ T cells had already undergone as many as seven divisions. Thus, proliferation of donor CD8+ T cells preceded the disappearance of host DCs. When C3H.SW donor CD8+ T cells were primed in vivo in irradiated B6 mice or ex vivo by host CD11c+ DCs for 24–36 hours, they were able to proliferate and differentiate into IFN-γ–producing cells in β2-microglobulin–deficient (β2m–/–) B6 recipients and to mediate acute GVHD in β2m–/– → B6 chimeric mice. These results indicate that, although host DCs disappear rapidly after allogeneic bone marrow transplantation, they prime donor T cells before their disappearance and play a critical role in triggering donor CD8+ T cell–mediated GVHD.
Chain association of pectic molecules during calcium‐induced gelation (1986)

Abstract The chain association of pectic molecules with different levels and patterns of esterification during calcium‐induced gelation was studied by methods such as light scattering, viscometry, and determination of calcium activity coefficient and of calcium transport parameter. A gel point can be determined, assuming a power law including a critical ratio (equivalent concentration of calcium ions/pectin carboxylic groups) and quasi‐critical exponents varying in the range 0.50–1.26. The values of these critical parameters were discussed as a function of polymer concentration, of level and pattern of esterification, and of the nature of the divalent counterion. The lower these values are, the better, apparently, the gel‐forming ability of the pectins is.
Methylphosphonates as probes of protein-nucleic acid interactions (1984)

Deoxydinucleoside methylphosphonates were prepared by chemical synthesis and were introduced stereospecifically into the lac operator at two sites. These sites within d(ApApTpTpGpTpGpApGpCpGpGpApTpApApCpApApTpT), segment I, and d(ApApTpTpGpTpTpApTpCpCpGpCpTpCpApCpApApTpT), segment II, are indicated by p. Each segment containing a chiral methylphosphonate was annealed to the complementary unmodified segment. The interactions of these four modified lac operators with lac repressor were analyzed by the nitrocellulose filter binding assay. Introduction of either chiral phosphonate in segment II had little effect on the stability of the repressor-operator complex. When methylphosphonates were introduced into segment I, the affinity of lac repressor for the modified operators was shown to be dependent on the stereochemical configuration of the methylphosphonate.
A dynamic link adaptation algorithm for IEEE 802.11 a wireless LANs (2004)

We present a simple but powerful dynamic link adaptation mechanism for wireless LANs, which are based on the IEEE 802.11a standard. Using this method, a transmitter is able to detect whether the quality of the link is improving or deteriorating, and based on this information to switch to a higher or lower transmission rate, respectively. For determining the link quality, the transmitter employs only information that is available locally. Therefore, the proposed method can be implemented without changes or enhancements to the current IEEE 802.11 standard. The efficiency of our method is investigated and evaluated by means of simulations.
퇴행성 슬관절염 환자에 대한 도침요법의 효능 및 안전성 연구: 임상예비연구 (2016)

Objectives : The Knee degenerative osteoarthritis patients are not satisfied with the conventional therapies of KDOA, which results in the use of alternative therapies. The miniscalpel acupuncture is effective in treating chronic soft tissue, releasing contractures. However, there is little scientific evidence supporting the use of miniscalpel acupuncture in knee degenerative osteoarthritis. This study was designed to obtain basic data for a further large-scale trial as well as provide information about the feasibility of miniscalpel acupuncture in knee degenerative osteoarthritis patients. Methods : We describe the protocol for a randomized controlled pilot clinical trial of 5 weeks duration. Twenty patients will be recruited and randomly allocated to two treatment groups: miniscalpel acupuncture treatment (experimental group); and acupuncture and electro-acupuncture treatment(control group). Miniscalpel acupuncture will be performed once with a 1-week interval for 3 weeks. Electro-acupuncture will be administered twice per week for a period of 3 weeks. The primary outcomes will be measured by visual analogue scale and range of motion. The secondary outcomes will be short-form McGill Pain Questionnaire and Western Ontario and McMaster Universities Osteoarthritis Index. Both primary and secondary outcomes will be measured at baseline and at 1, 2, 3 and 5 weeks(i.e. 2 weeks after treatment completion). Conclusions : This pilot study will provide a basic foundation for a future large-scale trial as well as information about the feasibility of miniscalpel acupuncture in knee degenerative osteoarthritis.
Evidence for posttranslational O-glycosylation of fetuin (1986)

Fetuin, a major glycoprotein in the serum of fetal calves that contains three N-linked and three O-linked carbohydrate side chains, was found to be synthesized in the liver with an 18 amino acid signal peptide, Met-X-X-X-X-Leu-Leu-X-Cys-Leu-Ala-X-Leu-X-X-Cys-X-X, and to undergo cotranslational N-glycosylation. In order to examine O-glycosylation, fetuin peptidyl-tRNA was purified from liver and analyzed for O-linked carbohydrate by quantitating the released [3H]GalNAcitol produced after beta-elimination in the presence of NaB3H4. Within the limits of the assay, less than 1.3% of the O-linked chains had been initiated. Additionally, rough microsomes were used to program a cell-free protein synthesis system. A radiolabeled fetuin intermediate was isolated by immunoprecipitation and shown to contain N-linked carbohydrate by binding to concanavalin A and by susceptibility to cleavage by endoglycosidase H. However, this fetuin intermediate was not detectably bound (less than 1%) by GalNAc-specific lectins, which were shown to bind asialoagalactofetuin. These results suggest that O-glycosylation of fetuin is a posttranslational event.
Loss of CD20 and Bound CD20 Antibody from Opsonized B Cells Occurs More Rapidly Because of Trogocytosis Mediated by Fc Receptor-Expressing Effector Cells Than Direct Internalization by the B Cells (2011)

We previously reported that 1 h after infusion of CD20 mAb rituximab in patients with chronic lymphocytic leukemia (CLL), >80% of CD20 was removed from circulating B cells, and we replicated this finding, based on in vitro models. This reaction occurs via an endocytic process called shaving/trogocytosis, mediated by FcγR on acceptor cells including monocytes/macrophages, which remove and internalize rituximab-CD20 immune complexes from B cells. Beers et al. reported that CD20 mAb-induced antigenic modulation occurs as a result of internalization of B cell-bound mAb-CD20 complexes by the B cells themselves, with internalization of ∼40% observed after 2 h at 37°C. These findings raise fundamental questions regarding the relative importance of shaving versus internalization in promoting CD20 loss and have substantial implications for the design of mAb-based cancer therapies. Therefore, we performed direct comparisons, based on flow cytometry, to determine the relative rates and extent of shaving versus internalization. B cells, from cell lines, from patients with CLL, and from normal donors, were opsonized with CD20 mAbs rituximab or ofatumumab and incubated for varying times and then reacted with acceptor THP-1 monocytes to promote shaving. We find that shaving induces considerably greater loss of CD20 and bound mAb from opsonized B cells in much shorter time periods (75-90% in <45 min) than is observed for internalization. Both shaving/trogocytosis and internalization could contribute to CD20 loss when CLL patients receive rituximab therapy, but shaving should occur more rapidly and is most likely to be the key mechanism of CD20 loss.
Long-term effects of rTMS on motor recovery in patients after subacute stroke (2010)

Positive long-term effects on motor recovery could be achieved after 10 daily sessions of high-frequency rTMS in conjunction with motor practice during the sub-acute period of stroke.
Fast Video Object Segmentation by Reference-Guided Mask Propagation (2018)

We present an efficient method for the semi-supervised video object segmentation. Our method achieves accuracy competitive with state-of-the-art methods while running in a fraction of time compared to others. To this end, we propose a deep Siamese encoder-decoder network that is designed to take advantage of mask propagation and object detection while avoiding the weaknesses of both approaches. Our network, learned through a two-stage training process that exploits both synthetic and real data, works robustly without any online learning or post-processing. We validate our method on four benchmark sets that cover single and multiple object segmentation. On all the benchmark sets, our method shows comparable accuracy while having the order of magnitude faster runtime. We also provide extensive ablation and add-on studies to analyze and evaluate our framework.