gebhart/patrepeval huggingface dataset:
Controllable Sequential Deposition of Planar CH3NH3PbI3 Perovskite Films via Adjustable Volume Expansion (2015)

We demonstrate a facile morphology-controllable sequential deposition of planar CH3NH3PbI3 (MAPbI3) film by using a novel volume-expansion-adjustable PbI2·xMAI (x: 0.1-0.3) precursor film to replace pure PbI2. The use of additive MAI during the first step of deposition leads to the reduced crystallinity of PbI2 and the pre-expansion of PbI2 into PbI2·xMAI with adjustable morphology, which result in about 10-fold faster formation of planar MAPbI3 film (without PbI2 residue) and thus minimize the negative impact of the solvent isopropanol on perovskites during the MAI intercalation/conversion step. The best efficiency obtained for a planar perovskite solar cell based on PbI2·0.15MAI is 17.22% (under one sun illumination), which is consistent with the stabilized maximum power output at an efficiency of 16.9%.
The structure and action of ricin, a cytotoxic N-glycosidase. (1991)

The X-ray structure of the heterodimeric plant cytotoxin ricin has been elucidated. The A chain, known to be a specific N-glycosidase, has a prominent active site cleft. The B chain is a two domain lectin, which arose from the replication of a primitive sugar binding peptide. The molecular model reveals residues which are likely to be important in the action of the protein. Site directed mutagenesis reveals the relative importance of a number of these groups. A model for the mechanism of the A chain, including steric strain of the scissile bond and carboxonium ion transition state stabilization is proposed.
Cytogenetic analysis of 434 consecutively ascertained specimens of non- Hodgkin's lymphoma: clinical correlations (1991)

Cytogenetic and histopathologic data were correlated with clinical parameters from 423 patients with non-Hodgkin's lymphoma (NHL). Clinical correlations were performed on subgroups of 149 patients with low-grade lymphoma (LG) and 205 patients with diffuse lymphoma with a large cell component (DLLC). Correlations were made between clinical outcome and individual recurring cytogenetic aberrations, each of which was noted in greater than 5% of cases belonging to LG NHL and DLLC, and derived measures of karyotypic complexity, comprising modal chromosome number, number of marker chromosomes, and number of translocation breakpoints. No correlations with survival were noted in LG NHL, although median follow-up was only 2 years. Seven patients with t(8;14) LG NHL had an indolent course. Among 104 patients with DLLC and abnormal karyotypes at diagnosis, breaks at 1q21-23 or more than 4 marker chromosomes was associated with a shortened median survival. Using these variables we constructed a proportional hazards model with a good fit to observed data. Breaks at 6q21-25 predicted a decreased probability of achieving remission. Patients with DLLC and breaks at 1q21-23 or 1p32-36 had a shorter duration of complete remission. Of 41 DLLC studied at relapse, the only long-term survivors had t(14;18).
Evolution of the Gene Lineage Encoding the Carbon Dioxide Receptor in Insects (2009)

A heterodimer of the insect chemoreceptors Gr21a and Gr63a has been shown to be the carbon dioxide receptor in Drosophila melanogaster (Meigen) (Diptera: Drosophilidae). Comparison of the genes encoding these two proteins across the 12 available drosophilid fly genomes allows refined definition of their N-termini. These genes are highly conserved, along with a paralog of Gr21a, in the Anopheles gambiae, Aedes aegypti, and Culex pipiens mosquitoes, as well as in the silk moth Bombyx mori and the red flour beetle Tribolium castaneum. In the latter four species we name these three proteins Gr1, Gr2, and Gr3. Intron evolution within this distinctive three gene lineage is considerable, with at least 13 inferred gains and 39 losses. Surprisingly, this entire ancient gene lineage is absent from all other available more basal insect and related arthropod genomes, specifically the honey bee, parasitoid wasp, human louse, pea aphid, waterflea, and blacklegged tick genomes. At least two of these species can detect carbon dioxide, suggesting that they evolved other means to do so.
Method of creating a Pd-covered single-atom sharp W pyramidal tip: Mechanism and energetics of its formation (2001)

Single-atom sharp pyramidal W tips, wrapped in a Pd overlayer, having atom-perfect wedges can be routinely and repeatedly created using a surface-science technique. This single-atom tip is thermally stable up to 1000 K because of the exceptionally large surface-energy anisotropy of the Pd covered W(111) surface. We conclude from atom-by-atom analysis that the W tip is covered with only one physical monolayer of Pd. We also investigate the mechanism and energetics of the atomic processes involved in its formation.
Neural Networks and the BiadVariance Dilemma (1992)

Feedforward neural networks trained by error backpropagation are examples of nonparametric regression estimators. We present a tutorial on nonparametric inference and its relation to neural networks, and we use the statistical viewpoint to highlight strengths and weaknesses of neural models. We illustrate the main points with some recognition experiments involving artificial data as well as handwritten numerals. In way of conclusion, we suggest that current-generation feedforward neural networks are largely inadequate for difficult problems in machine perception and machine learning, regardless of parallelversus-serial hardware or other implementation issues. Furthermore, we suggest that the fundamental challenges in neural modeling are about representation rather than learning per se. This last point is supported by additional experiments with handwritten numerals.
B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection (2000)

During B lymphocyte development, antibody genes are assembled by DNA recombination. Successful cell surface expression of IgM promotes developmental progression. However, when antigen receptors bind autoantigen, development is blocked and ongoing antibody gene recombination occurs, which often alters antibody specificity in a process called receptor editing. We demonstrate here a significant role of developmental block and receptor editing in B cell receptor quality control. During development a functional, non-self-reactive receptor undergoes receptor editing if its expression is below a certain threshold. Doubling the receptor gene dose promotes development in the absence of autoantigen, but allows editing when autoantigen is present. Thus, both underexpressed and harmful B cell receptors can undergo correction by receptor editing.
Alpina sjösediment - en studie av progalciala och sluttningspåverkande sjöar under Holocen i Abisko, Sverige och Tatrabergen, Polen (1994)

Alpina sjosediment - en studie av progalciala och sluttningspaverkande sjoar under Holocen i Abisko, Sverige och Tatrabergen, Polen
Novel properties of antimicrobial peptides. (2003)

Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of invading microbes. However, some studies proved that antimicrobial peptides are universal multifunctional molecules and their functions extend far beyond simple antibiotics. In this review we present an overview of the general mechanism of action of antimicrobial peptides and discuss some of their additional properties, like antitumour activity, mitogenic activity, role in signal transduction pathways and adaptive immune response.
Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma (2012)

Bendamustine, active in multiple myeloma (MM), is a bifunctional mechlorethamine derivative with alkylating properties. Bortezomib, approved to treat MM, is effective in combination with alkylators. The tolerability and efficacy of bendamustine plus bortezomib in relapsed/refractory MM was assessed in an open-label, dose-escalating, phase I/II study. Patients aged ≥18 years received intravenous bendamustine 50, 70, or 90 mg/m(2) (days 1 and 4) plus bortezomib 1·0 mg/m(2) (days 1, 4, 8, and 11) for up to eight 28-day cycles. No dose-limiting toxicity was observed after cycle 1; bendamustine 90 mg/m(2) plus bortezomib 1·0 mg/m(2) was designated the maximum tolerated dose (MTD). The most common grade 3/4 adverse events were leucopenia (58%), neutropenia (50%), lymphopenia (45%), and thrombocytopenia (30%). Primary efficacy measure was overall response rate (ORR), which was the combined complete response (CR), very good partial response (VGPR), partial response (PR), and minimal response (MR). ORR was 48% (one CR, two VGPR, nine PR, and seven MR) for all 40 enrolled patients, 52% (16/31) at the MTD (90 mg/m(2) ), and 42% and 46% for prior use of bortezomib (n = 31) or alkylators (n = 28) respectively. Bendamustine plus bortezomib was well tolerated with promising efficacy in this heavily pretreated population.
Sun's Link Service: a protocol for open linking (1989)

Sun's Link Service, a product shipped with Sun's programming in the large software development environment, the Network Software Environment, allows users to make and maintain explicit and persistent bidirectional relationships between autonomous front end applications. The Link Service defines a protocol for an extensible and loosely coupled, or open, hypertext system. An interesting instance of this is the ability to link to objects in closed hypertext systems if they integrate with the Link Service. The Link Service addresses link maintenance and automated versioning. Link endpoints, or nodes, are defined by the integrating applications, and are not restricted to points, whole documents, or cards.
Human intervertebral disc: Structure and function (1988)

This review begins with a brief introduction in which the development, blood supply and innervation of the intervertebral disc is considered, particularly as these may influence the following sections on structure and function. The three regions within the disc--that is, the nucleus pulposus, annulus fibrosus, and cartilage end plates--are considered in some detail. There appears to be no distinct border between the central nucleus pulposus and the outer annulus fibrosus, the main difference being in their fibrous structure. The fluid space is important in the nutrition of the disc, showing plastic deformation and recovery characteristics. The structural elements, both macroscopically and microscopically, together with the biochemical elements, are intimately related to function. The intervertebral disc should not be though of as a homogeneous and static structure; it has a heterogeneous composition and responds dynamically to applied loads. Neither should it be considered as an isolated structure because it interacts with the vertebral bodies, together constituting the vertebral unit. Furthermore, changes within the disc can, and do, have dramatic effects on vertebral column kinematics. The intervertebral disc is not inactive; it is capable of self-maintenance; in injury it can repair itself and has considerable regenerative properties.
Concerning an heuristic point of view toward the emission and transformation of light (1905)

A profound formal distinction exists between the theoretical concepts which physicists have formed regarding gases and other ponderable bodies and the Maxwellian theory of electromagnetic processes in so–called empty space. While we consider the state of a body to be completely determined by the positions and velocities of a very large, yet finite, number of atoms and electrons, we make use of continuous spatial functions to describe the electromagnetic state of a given volume, and a finite number of parameters cannot be regarded as sufficient for the complete determination of such a state. According to the Maxwellian theory, energy is to be considered a continuous spatial function in the case of all purely electromagnetic phenomena including light, while the energy of a ponderable object should, according to the present conceptions of physicists, be represented as a sum carried over the atoms and electrons. The energy of a ponderable body cannot be subdivided into arbitrarily many or arbitrarily small parts, while the energy of a beam of light from a point source (according to the Maxwellian theory of light or, more generally, according to any wave theory) is continuously spread an ever increasing volume. The wave theory of light, which operates with continuous spatial functions, has worked well in the representation of purely optical phenomena
Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent. (1976)

Bovine vascular endothelial cells do not grow when cultured at low density unless fibroblast growth factor is included in the culture medium. When endothelial cells obtained from the intimal surface of fetal and adult aortas were seeded at low density (8 cells per cm2), they formed small colonies of large, irregular, vacuolated cells. At very low density (0.3 cells per cm2) they did not survive. The addition of fibroblast growth factor to endothelial cells maintained at such low densities resulted in the formation of vigorously growing colonies of small, uniform cells. Electron microscopy showed that the cultured endothelial cells had the fine structure characteristics of endothelial cells. Immunofluorescence microscopy revealed antihemophilic factor (Factor VIII) antigen in the cells. Our results demonstrated that fibroblast growth factor permits the survival of endothelial cells plated at extremely low cell density. With the use of fibroblast growth factor, endothelial cell clones are easily produced.
Mobile frequency-hopping CDMA systems (2000)

Through analysis and simulation, a unified evaluation of the potential performance of both mobile peer-to-peer and sectorized cellular frequency-hopping code-division multiple-access (CDMA) systems is presented. The equivalent number of frequency channels and the minimum area-mean signal-to-noise ratio are defined and shown to be important parameters in understanding and predicting network capacity. The effects of spectral splatter are analyzed. Separated orthogonality is defined and shown to be useful in completely eliminating intracell or intrasector interference. Spatial diversity by postdetection rather than predetection combining is proposed and shown to be invaluable. Noncoherent demodulation by a frequency discriminator rather than parallel matched filters and envelope detectors is proposed and shown to be effective. It is shown that even without exploiting either its natural bandwidth advantage or power control, frequency-hopping CDMA provides a reverse-link capacity nearly the same as direct-sequence CDMA with realistic power-control imperfections.
Coordinated Multi-cell MIMO Systems with Cellular Block Diagonalization (2007)

A clustered base transceiver station (BTS) coordination strategy is proposed to realize the gains of multiuser MIMO communication in interference-limited cellular systems. In the proposed coordination strategy, users are divided into two groups: a full intra-cluster coordination group to enhance the sum rate gain and a limited inter-cluster coordination group to reduce interference for the cluster edge users. Multi-cell block diagonalization is used to coordinate the transmissions across multiple BTSs in the same cluster. Because of the per-BTS power constraints, three combined precoder and power allocation algorithms are considered in this paper with different performance complexity tradeoffs. Simulations show that the proposed coordination strategy improves the sum rate over conventional systems and reduces the impact of interference for the cluster-edge users.
Single-Molecule Kinetics of λ Exonuclease Reveal Base Dependence and Dynamic Disorder (2003)

We used a multiplexed approach based on flow-stretched DNA to monitor the enzymatic digestion of lambda-phage DNA by individual bacteriophage lambda exonuclease molecules. Statistical analyses of multiple single-molecule trajectories observed simultaneously reveal that the catalytic rate is dependent on the local base content of the substrate DNA. By relating single-molecule kinetics to the free energies of hydrogen bonding and base stacking, we establish that the melting of a base from the DNA is the rate-limiting step in the catalytic cycle. The catalytic rate also exhibits large fluctuations independent of the sequence, which we attribute to conformational changes of the enzyme-DNA complex.
Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors (2010)

The development of iminocyclitol-based small molecule libraries against a bacterial TGase is described. An iminocyclitol was conjugated with a pyrophosphate mimic using either a 1,3-dipolar cycloaddition or reductive amination reaction, which was then condensed with a variety of lipophilic carboxylic acids in an amide bond coupling to generate a desired molecular library. With assistance of microtiter plate-based combinatorial chemistry and in situ screening, a potential inhibitor, the first potent iminocyclitol-based inhibitor against bacterial TGases was efficiently developed.
Role for IKK2 in muscle: waste not, want not (2006)

Activation of transcription factor NF-kappaB, the major regulator of the inflammatory response, depends on the inhibitor of NF-kappaB kinase (IKK) complex, which is composed of 2 catalytic subunits, IKK1 and IKK2 (also known as IKKalpha and IKKbeta), and a regulatory subunit, IKKgamma (also known as NEMO). In this issue of the JCI, Mourkioti et al. show that muscle-specific disruption in mice of the gene encoding IKK2 prevents NF-kappaB activation in response to denervation or toxin-induced injury (see the related article beginning on page 2945). Importantly, this genetic manipulation prevents muscle wasting, thereby providing strong evidence in support of a major pathogenic role for inflammation in a variety of muscular dystrophies characterized by progressive muscle fiber degeneration.
Multiple binding sites for cellular proteins in the 3' end of Sindbis alphavirus minus-sense RNA (1993)

The 3' end of Sindbis virus minus-sense RNA was tested for its ability to bind proteins in mosquito cell extracts, using labeled riboprobes that represented different parts of this region. We found four domains in the first 250 nucleotides that could bind the same 50- and 52-kDa proteins, three with high affinity and one with low affinity, whereas tested domains outside this region did not bind these proteins. The first binding domain was found in the first 60 nucleotides, which represents the complement of the 5'-nontranslated region, the second in the next 60 nucleotides, the third in the following 60 nucleotides, and the fourth between nucleotides 194 and 249 (all numbering is 3' to 5'). The relative binding constants, Kr, of the first, second, and fourth sites were similar, whereas that of domain 2 was fivefold less. Deletion mapping of the first domain showed that the first 10 nucleotides were critical for binding. Deletion of nucleotides 2 to 4, deletion or replacement of nucleotide 5, or deletion of the first 15 nucleotides was deleterious for binding, deletion of nucleotides 10 to 15, 26 to 40, or 41 to 55 had little effect on the binding, and deletion of nucleotides 15 to to 25 increased the binding affinity. We also found that the corresponding riboprobes derived from two other alphaviruses, Ross River virus and Semliki Forest virus, and from rubella virus were also able to interact with the 50- and 52-kDa proteins. The Kr value for the Semliki Forest virus probe was similar to that for the Sindbis virus probe, while that for the Ross River virus probe was four times greater. The rubella virus probe was bound only weakly, consistent with the fact that mosquito cells are not permissive for rubella virus replication. We suggest that the binding of the 50- and 52-kDa proteins to the 3' end of alphavirus minus-sense RNA represents an important step in the initiation of RNA replication.
SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION (1937)

Journal Article SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION Get access WILDER PENFIELD, WILDER PENFIELD MONTREAL Search for other works by this author on: Oxford Academic PubMed Google Scholar EDWIN BOLDREY EDWIN BOLDREY MONTREAL Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 60, Issue 4, December 1937, Pages 389–443, https://doi.org/10.1093/brain/60.4.389 Published: 01 December 1937
Effect of Age on the Rate of Tooth Movement in Combination with Local Use of 1,25(OH) 2D3 and Mechanical Force in the Rat (1992)

The purpose of this study was to compare the amount and rate of tooth movement in young and mature rats administered 1,25(OH)2D3 simultaneous with application of mechanical force. In 30 seven-week-old and 30 28-week-old male Wistar rats, the right maxillary first molar was moved buccally with a fixed appliance. The appliances delivered forces ranging from 5 to 20 g. Twenty microL of 1,25(OH)2D3 (10(-10) and 10(-8) mol/L) was injected locally into the submucosal palatal area of the root bifurcation of the right first molar. The left side was injected with phosphate-buffered saline (PBS). In young rats receiving 10(-10) mol/L 1,25(OH)2D3 every three days, tooth movement significantly increased to 126% of that in PBS-injected control rats on day 20. In 1,25(OH)2D3-injected mature rats, tooth movement was stimulated markedly and increased with 10(-10) mol/L to 245% and with 10(-8) mol/L to 154% of the amount of tooth movement seen in the PBS-injected controls by the end of the experiment. PBS-injected rats had a plateau stage where tooth movement did not occur at all, while there was no such lag-time in the 1,25(OH)2D3-injected group which showed continuous tooth movement. The local injection of 1,25(OH)2D3 did not change serum calcium, phosphate, and alkaline phosphatase activity, and there were no apparent clinical or microscopic side-effects.
Negative thermal expansion in oriented crystalline polymers (1981)

Abstract Measurements on the thermal expansivity α ∥ and α ⟂ (along and normal to the draw direction, respectively) have been carried out for a series of oriented polymers with widely different crystallinities (0.36–0.81) and draw ratios (1–20) and over large temperature ranges covering the major amorphous transitions in each case. While α ⟂ increases with temperature, α ∥ tends to decrease sharply above the transition temperature. For highly crystalline polymers, α ∥ decreases to values typical of polymer crystals (−1 × 10 −5 K −1 ) and this can be attributed to the constraining effect of the crystalline bridges connecting the crystalline blocks. However, for polymers of lower crystallinity, α ∥ may become an order of magnitude more negative and this remarkable phenomenon is attributed to the rubber–elastic contraction of taut tie‐moleucles. Since taut tie‐molecules and bridges have drastically different effects on α ∥ at high temperatures, this allows a rough determination of their relative fractions.
Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol (2010)

We have performed a major preclinical validation of a new method for PGS and found that the technology performs approximately as well as a metaphase karyotype. We also directly measured the mechanism of aneuploidy in cleavage-stage human embryos and found high rates and distinct patterns of mitotic and meiotic aneuploidy.