gebhart/patrepeval huggingface dataset:
Advances in wireless terminals (1999)

The current wireless networks are being replaced by emerging wireless networking technologies that are intrinsically designed to support packet data and multimedia services. This will lead to novel networked applications and services, which in turn will require wireless terminals capable of exploiting these services. What shape will these next-generation wireless terminals take? The answer, based on the much talked about notion of "convergence", would appear to be a marriage of the laptop or PC with a wireless phone in the same package. We argue that such a complex one-size-fits-all voice-data integrated wireless terminal will, at best, be a point solution. Rather, with the availability of cheap radio and computing hardware and ubiquitous low-cost indoor and outdoor wireless networking infrastructures, the capability to access a wireless network will soon be embedded into a variety of devices, gadgets, and appliances with specialized functions in our environment. In this article we describe the technological challenges and identify potential solutions in designing these myriad future "wireless terminals" that will handle diverse data types, have limited battery resources, and operate in environments that are unplanned, insecure, and time-varying, and have context-dependent services.
Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors. (1990)

The aim of this investigation was to determine whether a correlation exists between expression of the multi-drug-resistance associated P-glycoprotein 170 (P-gp170) and the accumulation of rhodamine 123 in human tumors. We investigated a panel of inherently resistant cell lines originating from human kidney tumor specimens and chemotherapeutically pretreated leukemias. The expression of P-gp170 was evaluated by means of two different immunohistological methods using two monoclonal antibodies against P-gp170. We found a significant reciprocal correlation between expression of P-gp170 and accumulation of rhodamine 123. This supports the view that P-gp170 might function as efflux pump in human tumors, as previously described for experimental models.
Diseases of Poultry (1991)

Principles of disease prevention - diagnosis and control of nutritional diseases salmonella infections colibacillosis fowl cholera reimerella anatipestifer infection tuberculosis infectious coryza mycoplasmosis campylobacteriosis staphylococosis clostridial diseases bordetellosis other bacterial diseases avian chlamydiosis (psittacosis, ornithosis) fungal infections neoplastic diseases infectious bronchitis laryngotracheitis Newcastle disease and other avian paramyxoviridae infections avian encephalomyelitis influenza adenovirus infections pox duck hepatitis viral enteric infections viral arthritis infectious bursal disease chicken infections anaemia other viral infections external parasites and poultry pests internal parasites protozoa developmental, metabolic and other non-infectious disorders poisons and toxins diseases of unknown or complex aetiology and emerging diseases.
TROP2 Expressed in the Trunk of the Ureteric Duct Regulates Branching Morphogenesis during Kidney Development (2011)

TROP2, a cell surface protein structurally related to EpCAM, is expressed in various carcinomas, though its function remains largely unknown. We examined the expression of TROP2 and EpCAM in fetal mouse tissues, and found distinct patterns in the ureteric bud of the fetal kidney, which forms a tree-like structure. The tip cells in the ureteric bud proliferate to form branches, whereas the trunk cells differentiate to form a polarized ductal structure. EpCAM was expressed throughout the ureteric bud, whereas TROP2 expression was strongest at the trunk but diminished towards the tips, indicating the distinct cell populations in the ureteric bud. The cells highly expressing TROP2 (TROP2(high)) were negative for Ki67, a proliferating cell marker, and TROP2 and collagen-I were co-localized to the basal membrane of the trunk cells. TROP2(high) cells isolated from the fetal kidney failed to attach and spread on collagen-coated plates. Using MDCK cells, a well-established model for studying the branching morphogenesis of the ureteric bud, TROP2 was shown to inhibit cell spreading and motility on collagen-coated plates, and also branching in collagen-gel cultures, which mimic the ureteric bud's microenvironment. These results together suggest that TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
A visionary approach is what's needed (2000)

As more and more SEN children are joining mainstream education, Twinks Read has some advice for those working with the visually impaired.
Four peptides decrease the number of human pancreatic adenocarcinoma cells (2003)

Four peptide hormones significantly decrease the number of pancreatic adenocarcinoma cells within 24 h and inhibit the proliferation of these cells for at least 96 h. Their mechanism of doing so is via inhibition of DNA synthesis mediated in part by cyclic GMP.
Effects of brimonidine tartrate 0.1% ophthalmic solution on the pupil, refraction, and light reflex (2018)

This study aimed to assess changes in pupil size, uncorrected visual acuity, refraction, and the direct and consensual light reflexes after instillation of brimonidine 0.1% in healthy subjects. The investigation comprised 46 eyes of 23 healthy subjects with no eye diseases in whom brimonidine 0.1% was instilled in the right eye. Pupil size was measured quantitatively under photopic and scotopic conditions, uncorrected visual acuity, refraction, and direct and consensual light reflexes before and at 1, 6, and 24 h after instillation. We found No significant change was found in refraction or uncorrected visual acuity (P = 0.999 and P = 0.998, respectively). A significant reduction in pupil size was observed under scotopic conditions at 1 h and 6 h after instillation (P = 0.007 and P = 0.005, respectively). The rate of pupil contraction and constriction speed measured by light reflexes were significantly increased at 1 h and 6 h after instillation (P = 0.021 and P = 0.033, respectively). Brimonidine 0.1% induced a significant reduction in pupil size under scotopic conditions without a significant change in refraction or visual acuity due to suppression of the sympathetic nervous system.
Hydrolytic cleavage ofN6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases (2008)

Homogeneous adenine deaminases (EC 3.5.4.2) from the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe and a putative ADA (adenosine deaminase; EC 3.5.4.4) from Arabidopsis thaliana were obtained for the first time as purified recombinant proteins by molecular cloning of the corresponding genes and their overexpression in Escherichia coli. The enzymes showed comparable molecular properties with well-known mammalian ADAs, but exhibited much lower k(cat) values. Adenine was the most favoured substrate for the yeast enzymes, whereas the plant enzyme showed only very low activities with either adenine, adenosine, AMP or ATP. Interestingly, the yeast enzymes also hydrolysed N6-substituted adenines from cytokinins, a group of plant hormones, cleaving them to inosine and the corresponding side chain amine. The hydrolytic cleavage of synthetic cytokinin 2,6-di-substituted analogues that are used in cancer therapy, such as olomoucine, roscovitine and bohemine, was subsequently shown for a reference sample of human ADA1. ADA1, however, showed a different reaction mechanism to that of the yeast enzymes, hydrolysing the compounds to an adenine derivative and a side chain alcohol. The reaction products were identified using reference compounds on HPLC coupled to UV and Q-TOF (quadrupole-time-of-flight) detectors.The ADA1 activity may constitute the debenzylation metabolic route already described for bohemine and, as a consequence, it may compromise the physiological or therapeutic effects of exogenously applied cytokinin derivatives.
Fine Structure Constant Defines Visual Transparency of Graphene (2008)

There are few phenomena in condensed matter physics that are defined only by the fundamental constants and do not depend on material parameters. Examples are the resistivity quantum, h/e2 (h is Planck's constant and e the electron charge), that appears in a variety of transport experiments and the magnetic flux quantum, h/e, playing an important role in the physics of superconductivity. By and large, sophisticated facilities and special measurement conditions are required to observe any of these phenomena. We show that the opacity of suspended graphene is defined solely by the fine structure constant, a = e2/hc feminine 1/137 (where c is the speed of light), the parameter that describes coupling between light and relativistic electrons and that is traditionally associated with quantum electrodynamics rather than materials science. Despite being only one atom thick, graphene is found to absorb a significant (pa = 2.3%) fraction of incident white light, a consequence of graphene's unique electronic structure.
Cool Laser Optics Treatment of Large Telangiectasia of the Lower Extremities (1993)

These results compare favorably with other methods for treatment of lower extremity telangiectases. Successful treatment of large lower extremity telangiectases by simultaneous cooling and lasing with minimal side effects suggests a reduction of thermal injury to nonvascular tissue while allowing destruction of ectatic vasculature.
Gene Therapy of Prostate Cancer with the Soluble Vascular Endothelial Growth Factor Receptor Fk1 (2002)

A variety of novel therapeutic approaches have emerged recently for the treatment of human cancers. We have coupled two of these therapeutic approaches, gene therapy and antiangiogenic therapy and tested them in two murine prostate cancer models Recombinant adenovirus encoding the ligand-binding ectodomain of the VEGF receptor 2 (Flk1) fused to an Fc domain was administered to SCID mice carrying orthotopic human LNCaP tumors as well as to transgenic (TRAMP) mice with spontaneous prostate tumors. Ad Flk1-Fc injection reduced tumor growth by 66% for orthotopic LNCaP tumors and by 42% for spontaneous tumors in TRAMP mice. Microvessel density in the primary tumors was reduced by 68% and 40% in the two models respectively. A decrease in microvessel density was also observed in lymphatic metastases in Ad Flk1-Fc-treated TRAMP mice and was correlated with a decrease in the frequency of regional metastases in the treated animals. Survival time was also extended in the Ad Flk1-Fc-treated TRAMP mice relative to the control-treated animals. Our results suggest that adenoviral delivery of soluble Flk1 receptor can reduce vascular density and prostate tumor growth and prolong survival time in orthotopically implanted tumors as well as in spontaneous prostate tumors in transgenic animals.
Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (2012)

A pyrazolo-pyrimidinone based series of growth hormone secretagogue receptor type 1a (GHS-R1a) antagonists and inverse agonists were identified using a scaffold hop from known quinazolinone GHS-R1a modulators. Lipophilicity was reduced to decrease hERG activity while maintaining GHS-R1a affinity. SAR exploration of a piperidine substituent was used to identify small cyclic groups as a functional switch from partial agonists to neutral antagonists and inverse agonists. A tool compound was identified which had good overall properties and sufficient oral plasma and CNS exposure to demonstrate reduced food intake in mice through a mechanism involving GHS-R1a.
Localizing a Robot with Minimum Travel (1998)

We consider the problem of localizing a robot in a known environment modeled by a simple polygon P. We assume that the robot has a map of P but is placed at an unknown location inside P. From its initial location, the robot sees a set of points called the visibility polygon V of its location. In general, sensing at a single point will not suffice to uniquely localize the robot, since the set H of points in P with visibility polygon V may have more than one element. Hence, the robot must move around and use range sensing and a compass to determine its position (i.e., localize itself). We seek a strategy that minimizes the distance the robot travels to determine its exact location. We show that the problem of localizing a robot with minimum travel is NP-hard. We then give a polynomial time approximation scheme that causes the robot to travel a distance of at most (k - 1)d, where k = |H|, which is no greater than the number of reflex vertices of P, and d is the length of a minimum length tour that would allow the robot to verify its true initial location by sensing. We also show that this bound is the best possible.
SUPPRESSION OF THE IN VIVO HUMORAL AND CELLULAR IMMUNE RESPONSE BY STAPHYLOCOCCAL ENTEROTOXIN B (SEB) (1978)

SUMMARY In vitro blast transformation of mouse spleen and lymph node cells occurs in response to staphylococcal enterotoxin B (SEB), as measured by 3H-thymidine incorporation. This response appears to be similar to the stimulation by phytohaemagglutinin. Treatment with SEB immediately after skin grafting suppressed a first, but not a second-set allograft rejection in mice. Syngeneic lymph node cells stimulated in vitro by SEB and adoptively transferred to normal mice failed to transfer suppression of graft rejection. Immediate injection of SEB following immunization with sheep red blood cells exhibited a markedly suppressed plaque-forming and rosette-forming cell response, whereas no suppression of the antibody response to a thymus-indendent antigen Escherichia coli lipopolysaccharide, was observed. Introduction of SEB after the second immunization with sheep red blood cells showed no significant suppression effect in plaque formation. Formalinized or heat-treated SEB destroyed the mitogenic and immunosuppressive capability as tested by 3H-thymidine incorporation, skin rejection, and plaque formation. It is suggested that the mechanism of this immunosuppression involved the interaction of SEB with T cells, which in some manner block T cell function in the early recognition stage, probably through nonspecific mitogenic activity.
Validation of a single‐isotope‐labeled cholesterol tracer approach for measuring human cholesterol absorption (2004)

Cholesterol absorption is frequently determined using the plasma dual stable-isotope ratio method (PDSIRM). However, this method involves intravenous injection of stable-isotope-labeled cholesterol with simultaneous oral administration of differently labeled cholesterol, which results in high study costs and involves additional ethical considerations. The objective of the present study was to validate a simpler single-isotope method for determining cholesterol absorption against PDSIRM by using data from two previous studies. Enrichments of carbon-13 (13C and deuterium in red blood cells were analyzed by using differential isotope ratio MS. The area under the curve of 13C-enrichment in the plasma free-cholesterol pool was found to be significantly correlated with cholesterol absorption measured by using PDSIRM for study 1 (r = 0.85, P < 0.0001) and study 2 (r = 0.81, P < 0.0001). Average 13C-enrichment correlated with the area under the curve of 13C-enrichment in the plasma free cholesterol for both study 1 (r = 0.98, P < 0.0001) and study 2 (r = 1.00, P < 0.0001). Study 1 examined the efficacy and mechanisms of unesterified plant sterols and stanols on lipid profiles in hypercholesterolemic men and women, while study 2 investigated the effects of phytosterol vs. phytostanol esters on plasma lipid levels and cholesterol kinetics in hyperlipidemic men. Experimental approaches to determine cholesterol absorption were identical between the two studies. Consequently, in both studies, correlations (r = 0.88, P < 0.0001 for study 1, and r = 0.82, P < 0.0001 for study 2) were found between the average 13C-enrichment of plasma free cholesterol and cholesterol absorption measured by PDSIRM. These results suggest that a single-isotope-labeled cholesterol tracer approach can be used as a reliable noninvasive method to replace PDSIRM for examining changes in cholesterol absorption.
T‐T cell interactions are mediated by adhesion molecules (1990)

The mechanism by which T cells signal other T cells is not well defined. This was investigated by studying the ability of circulating T cells to induce the proliferation of autologous T cell clones. Peripheral blood T cells activated by cross-linking of the CD3/T cell receptor complex, which increased the expression of cell adhesion molecules LFA-1, LFA-3 and ICAM-1, induced the proliferation of autologous T cell clones. Irradiated antigen-activated peripheral blood T cells could also induce the proliferation of T cell clones which could not recognize that antigen. T-T cell activation required cell contact, was not major histocompatibility complex (MHC) restricted and was blocked by monoclonal antibodies directed against adhesion molecules CD2 and LFA-3 but was not blocked by antibody to class II MHC determinants. As CD2 is the natural ligand for LFA-3, increased expression of T cell surface adhesion molecules LFA-1, ICAM-1 and particularly LFA-3 during an inflammatory response may rapidly recruit T cells that are activated through the CD2 pathway. These results allow a simplified model to explain how relatively few antigen/MHC-specific T cells can recruit large numbers of non-antigen-specific T cells in the generation of an inflammatory response and postulates a novel role of the CD2 molecule in T cell immune function.
Antenna switch duplexer for dualband phone (GSM/DCS) using LTCC multilayer technology (2003)

The multilayer antenna switch duplexer is chiefly utilized for European dualband phones (GSM/DCS) and contributes not only to reducing the size and weight, but also to shortening the development time of the RF circuit and simplifying the assembly process. DOE and Monte Carlo simulation are utilized to develop the duplexer. These simulation methods are very efficient in shortening the development time and improving the manufacturing yield.
Optical Properties of Circulating Human Blood in the Wavelength Range 400–2500 nm (1999)

Knowledge about the optical properties μa,μs, and g of human blood plays an important role for many diagnostic and therapeutic applications in laser medicine and medical diagnostics. They strongly depend on physiological parameters such as oxygen saturation, osmolarity, flow conditions, haematocrit, etc. The integrating sphere technique and inverse Monte Carlo simulations were applied to measure μa,μs, and g of circulating human blood. At 633 nm the optical properties of human blood with a haematocrit of 10% and an oxygen saturation of 98% were found to be 0.210±0.002 mm-1 for μa,77.3±0.5 mm-1 for μs, and 0.994±0.001 for the g factor. An increase of the haematocrit up to 50% lead to a linear increase of absorption and reduced scattering. Variations in osmolarity and wall shear rate led to changes of all three parameters while variations in the oxygen saturation only led to a significant change of the absorption coefficient. A spectrum of all three parameters was measured in the wavelength range 400-2500 nm for oxygenated and deoxygenated blood, showing that blood absorption followed the absorption behavior of haemoglobin and water. The scattering coefficient decreased for wavelengths above 500 nm with approximately λ-1.7; the g factor was higher than 0.9 over the whole wavelength range. © 1999 Society of Photo-Optical Instrumentation Engineers.
Maturation of Tissue Engineered Cartilage Implanted in Injured and Osteoarthritic Human Knees (2006)

The regeneration of damaged organs requires that engineered tissues mature when implanted at sites of injury or disease. We have used new analytic techniques to determine the extent of tissue regeneration after treatment of knee injury patients with a novel cartilage tissue engineering therapy and the effect of pre-existing osteoarthritis on the regeneration process. We treated 23 patients, with a mean age of 35.6 years, presenting with knee articular cartilage defects 1.5 cm2 to 11.25 cm2 (mean, 5.0 cm2) in area. Nine of the patients had X-ray evidence of osteoarthritis. Chondrocytes were isolated from healthy cartilage removed at arthroscopy. The cells were cultured for 14 days, seeded onto esterified hyaluronic acid scaffolds (Hyalograft C), and grown for a further 14 days before implantation. A second-look biopsy was taken from each patient after 6 to 30 months (mean, 16 months). After standard histological analysis, uncut tissue was further analyzed using a newly developed biochemical protocol involving digestion with trypsin and specific, quantitative assays for type II collagen, type I collagen, and proteoglycan, as well as mature and immature collagen crosslinks. Cartilage regeneration was observed as early as 11 months after implantation and in 10 out of 23 patients. Tissue regeneration was found even when implants were placed in joints that had already progressed to osteoarthrosis. Cartilage injuries can be effectively repaired using tissue engineering, and osteoarthritis does not inhibit the regeneration process.
Interstitial laser phototherapy assisted by magnetic resonance imaging: A new technique for monitoring laser‐tissue interaction (1990)

The rapid technological advances of magnetic resonance imaging, laser fiberoptics, and compatible probes may allow treatment of deep and sometimes surgically unreachable tumors of the head and neck with minimal morbidity through interstitial laser phototherapy. In this study, a new application of magnetic resonance imaging was developed to monitor and quantify laser-induced tissue damages. Pig skin was exposed to increased levels of argon laser (514.5 nm) at energy densities between 62.5 and 375 J/cm2 as determined by an accurate and reproducible method of dosimetry. Thermal profiles were recorded using an infrared sensor and T1- and T2-weighted magnetic resonance images were taken; afterward, biopsies were performed to quantitate the level of tissue damage. Our results demonstrate that above a certain threshold of laser energy, the magnetic resonance imaging findings are temperature dependent. Appropriate development of a scale matching laser energies, temperature profiles, T1- and T2-weighted magnetic resonance images, and histological quantitation of tissue destruction will allow us to optimize the three-dimensional control and monitoring of laser-tissue interactions.
IMMUNOCHROMATOGRAPHIC PURIFICATION OF HUMAN URINARY LUTEINIZING HORMONE (1972)

Conventional fractionation methods have been described for the preparation of human urinary luteinizing hormone (LH) with a potency of 982 i.u./mg by biological assay and 1166 i.u. by radioimmunoassay (Donini & Donini, 1969), and for the preparation of pituitary LH with a potency of 5·3 mg equiv. NIH-LH-S3 (Hartree, 1966) and 8·9 mg equiv. NIH-LH-S1 (Rathnam & Saxena, 1970). (According to Rosemberg (1968), 1 mg NIH-LH-S1 is equivalent to 588 i.u. LH of the 2nd-IRP-HMG. 1 mg NIH-LH-S3 corresponds to about 0·8 mg NIH-LH-S1 (personal communication from Dr A. E. Wilhelmi, Emory University, Atlanta, Georgia, U.S.A., to Dr B. Louwerens, N.V. Organon, Oss; 14 June 1966).) An immunoadsorbent of rabbit antiserum to purified human chorionic gonadotrophin (HCG) was used to purify LH from the main and side fractions obtained during the preparation of follicle-stimulating hormone (FSH) from menopausal urine (van Hell, Schuurs & den Hollander, 1972). The immunoglobulin fraction of