gebhart/patrepeval huggingface dataset:
Flexible Nanogenerators Based on Graphene Oxide Films for Acoustic Energy Harvesting (2012)

Graphenoxidfilme wurden als kostengünstige und flexible Nanogeneratoren hergestellt, die akustische Energie mit einem Wirkungsgrad von 12.1 % in Elektrizität umwandeln (siehe Bild). Der erzeugte Strom hing stark vom pH-Wert der Suspensionen ab, die zur Herstellung der Graphenoxidfilme verwendet wurden. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Blur identification based on kurtosis minimization (2005)

In this paper, we describe an algorithm for identifying a parametrically described blur based on kurtosis minimization. Using different choices for the parameters of the blur, the noisy blurred image is restored using Wiener filter. We use the kurtosis as a measurement of the quality of the restored image. From the set of the candidate deblurred images, the one with the minimum kurtosis is selected. The proposed technique is tested in a simulated experiment on a variety of blurs including atmospheric turbulence blurs, Gaussian blurs, and out-of-focus blurs. The proposed approach is also tested on real blurred images. Moreover, we test the performance when a wrong blur model is given. Our experiments show that the kurtosis minimization measurements match well with methods that maximize PSNR.
Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation. (1992)

The acute promyelocytic leukemia 15;17 chromosomal translocation fuses the PML gene to the RAR alpha locus. The resulting chimeric gene encodes for a putative PML-RAR alpha fusion protein. PML is a putative transcriptional factor and RAR alpha is one of the nuclear retinoic acid receptors through which retinoic acid regulates gene expression. In this study, we investigated the retinoid binding and biochemical properties of the PML-RAR alpha protein by size exclusion high-performance liquid chromatography and immunoblot analysis and compared them with those of normal RAR alpha. The introduction of the expression vector PSG5/PML-RAR alpha into COS-1 cells led to high levels of expression of the PML-RAR alpha fusion protein. This protein was primarily localized in the nucleus and bound retinoids with the same affinity and specificity as the wild type RAR alpha receptor. The PML-RAR alpha fusion protein, but not the RAR alpha, was found in high molecular weight complexes with either itself or other nuclear factors. In the acute promyelocytic leukemia-derived cell line NB4, which contains the t(15;17) chromosomal marker, the PML-RAR alpha product was also found as a high molecular complex. The interaction of the PML-RAR alpha with itself or with other nuclear proteins may be important in understanding the role of the PML-RAR alpha fusion protein in promyelocytic leukemogenesis.
Optical information processing based on an associative-memory model of neural nets with thresholding and feedback (1985)

The remarkable collective computational properties of the Hopfield model for neural networks [Proc. Nat. Acad. Sci. USA 79, 2554 (1982)] are reviewed. These include recognition from partial input, robustness, and error-correction capability. Features of the model that make its optical implementation attractive are discussed, and specific optical implementation schemes are given.
Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study (2006)

Green tea catechins (GTCs) proved to be effective in inhibiting cancer growth in several experimental models. Recent studies showed that 30% of men with high-grade prostate intraepithelial neoplasia (HG-PIN) would develop prostate cancer (CaP) within 1 year after repeated biopsy. This prompted us to do a proof-of-principle clinical trial to assess the safety and efficacy of GTCs for the chemoprevention of CaP in HG-PIN volunteers. The purity and content of GTCs preparations were assessed by high-performance liquid chromatography [(-)-epigallocathechin, 5.5%; (-)-epicatechin, 12.24%; (-)-epigallocatechin-3-gallate, 51.88%; (-)-epicatechin-3-gallate, 6.12%; total GTCs, 75.7%; caffeine, <1%]. Sixty volunteers with HG-PIN, who were made aware of the study details, agreed to sign an informed consent form and were enrolled in this double-blind, placebo-controlled study. Daily treatment consisted of three GTCs capsules, 200 mg each (total 600 mg/d). After 1 year, only one tumor was diagnosed among the 30 GTCs-treated men (incidence, approximately 3%), whereas nine cancers were found among the 30 placebo-treated men (incidence, 30%). Total prostate-specific antigen did not change significantly between the two arms, but GTCs-treated men showed values constantly lower with respect to placebo-treated ones. International Prostate Symptom Score and quality of life scores of GTCs-treated men with coexistent benign prostate hyperplasia improved, reaching statistical significance in the case of International Prostate Symptom Scores. No significant side effects or adverse effects were documented. To our knowledge, this is the first study showing that GTCs are safe and very effective for treating premalignant lesions before CaP develops. As a secondary observation, administration of GTCs also reduced lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia.
Vaccines for gonorrhea: where are we on the curve? (1995)

Human antibodies that bind the gonococcal outer membrane modulate gonorrheal transmission and disease. The effects of antibody binding can favor either the host or the bacteria, and depend on the antigen involved. An effective gonococcal vaccine is feasible, but only by the careful selection and formulation of gonococcal antigens that elicit only host-protective antibodies.
A physical charge-based model for non-fully depleted SOI MOSFET's and its use in assessing floating-body effects in SOI CMOS circuits (1995)

A new model for the non-fully depleted (NFD) SOI MOSFET is developed and used to study floating-body effects in SOI CMOS circuits. The charge-based model is physical, yet compact and thus suitable for device/circuit simulation. Verified by numerical device simulations and test-device measurements, and implemented in (SOI)SPICE, it reliably predicts floating-body effects resulting from free-carrier charging in the NFD/SOI MOSFET, including the purportedly beneficial supra-ideal sub-threshold slope due to impact ionization and a saturation current enhancement due to thermal generation. SOISPICE CMOS circuit simulations reveal that the former effect is not beneficial and could be detrimental, but the latter effect can be beneficial, especially in low-voltage applications, when accompanied by a dynamic floating-body effect that effectively reduces static power. The dynamic floating-body effects are hysteretic, however, and hence exploitation of the beneficial ones will necessitate device/circuit design scrutiny aided by physical models such as the one presented herein.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Decoding the secrets of spider silk (2011)

Spider silks have been employed by man for several thousands of years. Spider silks possess extraordinary mechanical properties due to a combination of strength and extensibility that are superior to most man-made fibers. Spider silk fibers are a protein-based material produced in a highly sophisticated hierarchical process under mild conditions. Here, we review the current understanding of spider silk and its assembly process, as well as discuss the application of silk-based materials to the fields of biomedicine and materials engineering.
Probing infectious disease by single-cell RNA sequencing: Progresses and perspectives (2020)

The increasing application of single-cell RNA sequencing (scRNA-seq) technology in life science and biomedical research has significantly increased our understanding of the cellular heterogeneities in immunology, oncology and developmental biology. This review will summarize the development of various scRNA-seq technologies; primarily discussing the application of scRNA-seq on infectious diseases, and exploring the current development, challenges, and potential applications of scRNA-seq technology in the future.
Observation of Hybridization and Dehybridization of Thiol-Tethered DNA Using Two-Color Surface Plasmon Resonance Spectroscopy (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTObservation of Hybridization and Dehybridization of Thiol-Tethered DNA Using Two-Color Surface Plasmon Resonance SpectroscopyKevin A. Peterlinz, Rosina M. Georgiadis, Tonya M. Herne, and Michael J. TarlovView Author Information Department of Chemistry, Boston University Boston, Massachusetts 02215 National Institutes of Standards and Technology Process Measurements Division Gaithersburg, Maryland 20899 Cite this: J. Am. Chem. Soc. 1997, 119, 14, 3401–3402Publication Date (Web):April 9, 1997Publication History Received23 December 1996Published online9 April 1997Published inissue 1 April 1997https://doi.org/10.1021/ja964326cCopyright © 1997 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3365Altmetric-Citations412LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (105 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Genetics,Hybridization,Molecules,Surface plasmon resonance spectroscopy,Thickness Get e-Alerts
Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders (2006)

An acquired gain-of-function mutation in the Janus kinase 2 (JAK2-V617F) is frequently found in patients with myeloproliferative disorders (MPDs). To test the hypothesis that JAK2-V617F is the disease-initiating mutation, we examined whether all cells of clonal origin carry the JAK2-V617F mutation. Using allele-specific polymerase chain reaction (PCR) assays for the JAK2 mutation and for the X-chromosomal clonality markers IDS and MPP1, we found that the percentage of granulocytes and platelets with JAK2-V617F was often markedly lower than the percentage of clonal granulocytes determined by IDS or MPP1 clonality assays in female patients. Using deletions of chromosome 20q (del20q) as an autosomal, X-chromosome-independent clonality marker, we found a similar discrepancy between the percentage of cells carrying JAK2-V617F and del20q. Our results suggest that in a proportion of patients with MPDs, JAK2-V617F occurs on the background of clonal hematopoiesis caused by a somatic mutation in an as-yet-unknown gene.
Synthesis, Isolation, and Characterization of 2‘-Paclitaxel Glycinate:  An Application of the Bsmoc Protecting Group (2003)

The relevance of the Bsmoc protecting group in the synthesis of moisture- and base-sensitive compounds has been demonstrated by the preparation of 2'-paclitaxel glycinate with use of the solid anhydrous base, 4-piperidinopiperidine in DCM solvent.
Screening of Chinese and Mongolian herbal drugs for anti‐human immunodeficiency virus type 1 (HIV‐1) activity (2002)

Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type-1 (HIV-1) inhibitory activity. Of the 60 extracts, 23 showed anti-HIV activity. Bioassay-guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha, led to the isolation of two alkaloids, aromoline and FK-3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV-1 on MT-4 cells at 31.3 and 7.8 microg/mL, respectively.
Quantitative analysis of agonist‐dependent parathyroid hormone receptor trafficking in whole cells using a functional green fluorescent protein conjugate (2001)

Many G-protein coupled receptors (GPCRs) undergo ligand-dependent internalization upon activation. The parathyroid hormone (PTH) receptor undergoes endocytosis following prolonged exposure to ligand although the ultimate fate of the receptor following internalization is largely unknown. To investigate compartmentalization of the PTH receptor, we have established a stable cell line expressing a PTH receptor-green fluorescent protein (PTHR-GFP) conjugate and an algorithm to quantify PTH receptor internalization. HEK 293 cells expressing the PTHR-GFP were compared with cells expressing the wild-type PTH receptor in whole-cell binding and functional assays. 125I-PTH binding studies revealed similar Bmax and kD values in cells expressing either the PTHR-GFP or the wild-type PTH receptor. PTH-induced cAMP accumulation was similar in both cell lines suggesting that addition of the GFP to the cytoplasmic tail of the PTH receptor does not alter the ligand binding or G-protein coupling properties of the receptor. Using confocal fluorescence microscopy, we demonstrated that PTH treatment of cells expressing the PTHR-GFP conjugate produced a time-dependent redistribution of the receptor to the endosomal compartment which was blocked by pretreatment with PTH antagonist peptides. Treatment with hypertonic sucrose prevented PTH-induced receptor internalization, suggesting that the PTH receptor internalizes via a clathrin-dependent mechanism. Moreover, co-localization with internalized transferrin showed that PTHR-GFP trafficking utilized the endocytic recycling compartment. Experiments using cycloheximide to inhibit protein synthesis demonstrated that recycling of the PTHR-GFP back to the plasma membrane was complete within 1-2 h of ligand removal and was partially blocked by pretreatment with cytochalasin D, but not nocodazole. We also demonstrated that the PTH receptor, upon recycling to the plasma membrane, is capable of undergoing a second round of internalization, a finding consistent with a role for receptor recycling in functional resensitization.
Automated monitoring functions for improved power system operation and control (2005)

This paper describes how new functions for automated analysis of data collected in substations of an electric power system can be developed. The new functions are first defined and architecture of the integrated substation solution is proposed. Database and user interfacing needs are also presented. Once fully implemented, this solution will serve both local and remote operators allowing further benefits to be drawn from the concept of substation data integration and information exchange.
Effective Phagocytosis and Killing ofCandida albicansvia Targeting FcγRI (CD64) or FcαRI (CD89) on Neutrophils (1999)

Invasive fungal infections are an increasing problem for immunocompromised patients. As an approach to improve targeting of polymorphonuclear leukocytes (PMNL) toward Candida albicans, the effect of bispecific antibodies (BsAbs) directed against C. albicans and either FcalphaRI or FcgammaRI was evaluated. Control PMNL and in vivo granulocyte colony-stimulating factor (G-CSF)-primed PMNL served as effector cells. A new radiometric killing assay for measuring candidacidal activity was developed to facilitate quantification of PMNL-mediated killing of C. albicans. BsAbs directed to either FcgammaRI (CD64) or FcalphaRI (CD89) on human PMNL effectively enhanced both phagocytosis and killing of C. albicans in vitro. Fungicidal activity triggered via FcgammaRI required in vivo priming with G-CSF, whereas FcalphaRI-mediated activity was not dependent on this growth factor. Furthermore, PMNL from human FcgammaRI-transgenic mice effectively phagocytosed and eliminated C. albicans in the presence of BsAbs. These results document the capacity of FcR-directed BsAbs and G-CSF to trigger antifungal immune responses.
Therapeutic siRNA: principles, challenges, and strategies. (2012)

RNA interference (RNAi) is a remarkable endogenous regulatory pathway that can bring about sequence-specific gene silencing. If harnessed effectively, RNAi could result in a potent targeted therapeutic modality with applications ranging from viral diseases to cancer. The major barrier to realizing the full medicinal potential of RNAi is the difficulty of delivering effector molecules, such as small interfering RNAs (siRNAs), in vivo. An effective delivery strategy for siRNAs must address limitations that include poor stability and non-targeted biodistribution, while protecting against the stimulation of an undesirable innate immune response. The design of such a system requires rigorous understanding of all mechanisms involved. This article reviews the mechanistic principles of RNA interference, its potential, the greatest challenges for use in biomedical applications, and some of the work that has been done toward engineering delivery systems that overcome some of the hurdles facing siRNA-based therapeutics.
The Thrombophilic State in Acute Promyelocytic Leukemia (1999)

Acute promyelocytic leukemia is characterized by the association with a severe coagulopathy resulting in hemorrhagic manifestations. The pathogenesis underlying the hemorrhagic syndrome is complex and involves the activation of the coagulation cascade and the fibrinolytic system. All-trans-retinoic acid (ATRA) appears to correct both procoagulant and fibrinolytic activities in vitro and in vivo. Early results of treatment with arsenic trioxide, which acts by inducing apoptosis of the leukemic promyelocytes, also show regression in the coagulopathy with a decrease in fibrin degradation products and D-Dimer. A clear understanding of the relationship between laboratory changes and the effects of ATRA and arsenic trioxide requires further studies.
A 1.9-GHz wide-band IF double conversion CMOS receiver for cordless telephone applications (1997)

A monolithic 1.9-GHz, 198-mW, 0.6-/spl mu/m CMOS receiver which meets the specifications of the Digital Enhanced Cordless Telecommunications (DECT) standard is described. All of the RF, IF, and baseband receiver components, with the exception of the frequency synthesizers, have been integrated into a single chip solution. A description is given of a wide-band IF with double conversion architecture which eliminates the need for the discrete-component noise and IF filters in addition to facilitating the eventual integration of the frequency synthesizer blocks with on-chip VCO's. The prototype device utilizes a 3.3-V supply and includes a low noise amplifier, an image-rejection mixer, and two quadrature baseband signal paths each of which includes a second-order Sallen and Key anti-alias filter, an eighth-order switched-capacitor filter network followed by a 10-b pipelined analog-to-digital converter (ADC). The experimental device has a measured receiver reference sensitivity of -90 dBm, an input referred IP3 of -7 dBm, a P/sub -1 dB/ of -24 dBm, and an image-rejection ratio of -55 dBc across the DECT bands.
Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis (2010)

Fatty acid metabolism is perturbed in atherosclerotic lesions, but whether it affects lesion formation is unknown. To determine whether fatty acid synthesis affects atherosclerosis, we inactivated fatty-acid synthase (FAS) in macrophages of apoE-deficient mice. Serum lipids, body weight, and glucose metabolism were the same in FAS knock-out in macrophages (FASKOM) and control mice, but blood pressure was lower in FASKOM animals. Atherosclerotic extent was decreased 20-40% in different aortic regions of FASKOM as compared with control mice on Western diets. Foam cell formation was diminished in FASKOM as compared with wild type macrophages due to increased apoAI-specific cholesterol efflux and decreased uptake of oxidized low density lipoprotein. Expression of the anti-atherogenic nuclear receptor liver X receptor alpha (LXRalpha; Nr1h3) and its downstream targets, including Abca1, were increased in FASKOM macrophages, whereas expression of the potentially pro-atherogenic type B scavenger receptor CD36 was decreased. Peroxisome proliferator-activated receptor alpha (PPARalpha) target gene expression was decreased in FASKOM macrophages. PPARalpha agonist treatment of FASKOM and wild type macrophages normalized PPARalpha target gene expression as well as Nr1h3 (LXRalpha). Atherosclerotic lesions were more extensive when apoE null mice were transplanted with LXRalpha-deficient/FAS-deficient bone marrow as compared with LXRalpha-replete/FAS-deficient marrow, consistent with anti-atherogenic effects of LXRalpha in the context of FAS deficiency. These results show that macrophage FAS deficiency decreases atherosclerosis through induction of LXRalpha and suggest that FAS, which is induced by LXRalpha, may generate regulatory lipids that cause feedback inhibition of LXRalpha in macrophages.
StarOS, a multiprocessor operating system for the support of task forces (1979)

StarOS is a message-based, object-oriented, multiprocessor operating system, specifically designed to support task forces, large collections of concurrently executing processes that cooperate to accomplish a single purpose. StarOS has been implemented at Carnegie-Mellon University for the 50 processor Cm* multi-microprocessor computer.