gebhart/patrepeval huggingface dataset:
A High-Density Scalable Twin Transistor RAM (TTRAM) With Verify Control for SOI Platform Memory IPs (2007)

Several high-density SOI memory technologies utilizing the body floating effects have been proposed. Conditions needed for SoC memory IPs for many kinds of applications are not only performance but also suitability for platform technologies. We had reported TTRAM (Twin Transistor RAM) and (Enhanced TTRAM) which are high-density capacitorless SOI-CMOS compatible memory IPs. A platform design methodology becomes the mainstream, providing QTAT and low-cost design. Now, we have upgraded the with application-required functions called scalable TTRAM. This memory IP can be applied to many kinds of applications using the verify control technique with compact actively body-bias controlled (ABC) sense amplifier, and the unique test mode functions have also been proposed for practical usage. The test chip of 4 Mbit macro fabricated with 90 nm standard SOI CMOS achieves performance of 263 MHz high-speed random access, 79 mW/4 Mb lower active power dissipation, 453 MHz data transfer of page/burst mode and lower stand-by current mode of 5 s data retention time. The scalable TTRAM can play the role of on-chip SoC memory IPs, for example, in consumer, mobile, and MPU/game applications.
LY2439821, a humanized anti–interleukin‐17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double‐blind, placebo‐controlled, proof‐of‐concept study (2010)

LY2439821 added to oral DMARDs improved signs and symptoms of RA, with no strong adverse safety signal noted. This first evaluation of LY2439821 supports neutralization of IL-17 as a potential novel goal for the treatment of RA.
The nature of Pd–carbene and Pd–halogen bonds in (bisNHC)PdX2 type catalysts: insights from density functional theory (2015)

Pd–carbene and Pd–halogen play a key role in the catalytic activity of (bisNHC)PdX<sub>2</sub> complexes and they can be fine-tuned with proper substitution in the carbene moiety and choosing a weakly coordinating halide ion.
Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy (2003)

Spinal muscular atrophy (SMA) is a recessive autosomal disorder characterized by degeneration of lower motor neurons caused by mutations of the survival motor neuron gene (SMN1). No curative treatment is known so far. Mutant mice carrying homozygous deletion of Smn exon 7 directed to neurons display skeletal muscle denervation, moderate loss of motor neuron cell bodies and severe axonal degeneration. These features, similar to those found in human SMA, strongly suggest the involvement of a dying back process of motor neurons and led us to test whether neurotrophic factors might have a protective role in SMA. We report here the therapeutic benefits of systemic delivery of cardiotrophin-1 (CT-1), a neurotrophic factor belonging to the IL-6 cytokine family. Intra-muscular injection of adenoviral vector expressing CT-1, even at very low dose, improves median survival, delays motor defect of mutant mice and exerts protective effect against loss of proximal motor axons and aberrant cytoskeletal organization of motor synaptic terminals. In spite of the severity of SMA phenotype in mutant mice, CT-1 is able to slow down disease progression. Neuroprotection could be regarded as valuable therapeutic approach in SMA.
Diblock Glycopolymers Promote Colloidal Stability of Polyplexes and Effective pDNA and siRNA Delivery under Physiological Salt and Serum Conditions (2011)

A series of glycopolymers composed of 2-deoxy-2-methacrylamido glucopyranose (MAG) and the primary amine-containing N-(2-aminoethyl) methacrylamide (AEMA) were synthesized via aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization. The colloidal stability of the polyplexes formed with three diblock glycopolymers and pDNA was assessed using dynamic light scattering, and the polyplexes were found to be stable against aggregation in the presence of salt and serum over the 4 h time period studied. Delivery experiments were performed in vitro to examine the cellular uptake, transfection efficiency, and cytotoxicity of the glycopolymer/pDNA polyplexes in cultured HeLa cells and the diblock copolymer with the shortest AEMA block was found to be the most effective. Additionally, the ability of the diblock glycopolymers to deliver siRNA to U-87 (glioblastoma) cells was screened, and the diblock copolymer with the longest AEMA block was found to have gene knockdown efficacy similar to Lipofectamine 2000.
Assembly and Intracellular Transport of MHC Class I Molecules (1993)

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
DeepView: a channel for distributed microscopy (1999)

The paper outlines the requirements, architecture, and design of a "Microscopy Channel" over the wide area network. A microscopy channel has a listing of available online microscopes, where users can seamlessly participate in an experiment, acquire expert opinions, collect and process data, and store it in their electronic notebook. The proposed channel is a collaborative problem solving environment (PSE) that leverages existing computational toolkits to support simulation and inverse problem solving. Our testbed includes several unique electron and optical microscopes with applications ranging from material science to biology. We have studied current commercial services from OMG and concluded that three basic services are needed to meet the scalability and functionality constraints. These include: Instrument Services (IS), Exchange Services (ES), and Computational Services (CS). These services sit on top of CORBA and its enabling services (naming, trading, security, and notification). IS provide a layer of abstraction for controlling any type of microscope. ES provide a common set of utilities for information management and transaction. CS provide the analytical capabilities needed for online microscopy. The enabling services provide a mechanism for resource discovery, safety and security, and decoupled communication.
A Clinical Investigation on Zhi Ling Tang for Treatment of Senile Dementia (2000)

Zhi 石楠唐(ZLT [标志：看见文本] ，一张 TCM 药方为填满设计了本质，补充的髓，鼓舞的 qi，温暖的 yang，搬迁的血壅滞和痰， tonifying 大脑，和鼓舞的心理活动) 在老年性痴呆(SD ) 的 32 种情况中被使用。术后疗法，浆液胆固醇(Tch ) 的层次，甘油三酸酯(TG ) ，和血浆类脂化合物过氧化物(LPO ) 被降低；高密度脂蛋白(HDL ) 和在 RBC 的超级氧化物歧化酶(草皮) 的活动的内容显著地提高了，脑血流量被增加；当 P3 的振幅提高了时， P300 和 P3 波浪的潜伏期被弄短；并且地志的脑电图，修订 Hasegawa 痴呆规模(HDS ) 分数(P
Lifecourse Health Development: Past, Present and Future (2013)

During the latter half of the twentieth century, an explosion of research elucidated a growing number of causes of disease and contributors to health. Biopsychosocial models that accounted for the wide range of factors influencing health began to replace outmoded and overly simplified biomedical models of disease causation. More recently, models of lifecourse health development (LCHD) have synthesized research from biological, behavioral and social science disciplines, defined health development as a dynamic process that begins before conception and continues throughout the lifespan, and paved the way for the creation of novel strategies aimed at optimization of individual and population health trajectories. As rapid advances in epigenetics and biological systems research continue to inform and refine LCHD models, our healthcare delivery system has struggled to keep pace, and the gulf between knowledge and practice has widened. This paper attempts to chart the evolution of the LCHD framework, and illustrate its potential to transform how the MCH system addresses social, psychological, biological, and genetic influences on health, eliminates health disparities, reduces chronic illness, and contains healthcare costs. The LCHD approach can serve to highlight the foundational importance of MCH, moving it from the margins of national debate to the forefront of healthcare reform efforts. The paper concludes with suggestions for innovations that could accelerate the translation of health development principles into MCH practice.
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. (1993)

Increasing evidence suggests that angiotensin II (Ang II) may act as a growth factor for the heart. However, direct effects of Ang II on mammalian cardiac cells (myocytes and nonmyocytes), independent of secondary hemodynamic and neurohumoral effects, have not been well characterized. Therefore, we analyzed the molecular phenotype of cultured cardiac cells from neonatal rats in response to Ang II. In addition, we examined the effects of selective Ang II receptor subtype antagonists in mediating the biological effects of Ang II. In myocyte culture, Ang II caused an increase in protein synthesis without changing the rate of DNA synthesis. In contrast, Ang II induced increases in protein synthesis, DNA synthesis, and cell number in nonmyocyte cultures (mostly cardiac fibroblasts). The Ang II-induced hypertrophic response of myocytes and mitogenic response of fibroblasts were mediated primarily by the AT1 receptor. Ang II caused a rapid induction of many immediate-early genes (c-fos, c-jun, jun B, Egr-1, and c-myc) in myocyte and nonmyocyte cultures. Ang II induced "late" markers for cardiac hypertrophy, skeletal alpha-actin and atrial natriuretic factor expression, within 6 hours in myocytes. Ang II also caused upregulation of the angiotensinogen gene and transforming growth factor-beta 1 gene within 6 hours. Induction of immediate-early genes, late genes, and growth factor genes by Ang II was fully blocked by an AT1 receptor antagonist but not by an AT2 receptor antagonist. These results indicate that: (1) Ang II causes hypertrophy of cardiac myocytes and mitogenesis of cardiac fibroblasts, (2) the phenotypic changes of cardiac cells in response to Ang II in vitro closely mimic those of growth factor response in vitro and of load-induced hypertrophy in vivo, (3) all biological effects of Ang II examined here are mediated primarily by the AT1 receptor subtype, and (4) Ang II may initiate a positive-feedback regulation of cardiac hypertrophic response by inducing the angiotensinogen gene and transforming growth factor-beta 1 gene.
Social Support in Laryngeal Cancer Survivors (1994)

Patients who had laryngectomies were grouped according to adjustment scales into "good copers" and "poorer copers." More than 70% of the laryngeal cancer survivors were well adjusted and classified as "good copers." Three social support scales were administered and revealed that "good copers" perceived themselves as having better quality networks and more functional support. A subjective self-evaluation of the subjects’ voices revealed a relationship between perceived voice quality, adjustment, and perceived social support. Rehabilitation for some patients with laryngectomies may need to include more direct nurturing; speech-language pathologists may want to suggest self-help groups or professional support counseling.
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor (1996)

We describe the cloning of a human gene, named ChemR1, encoding a new putative chemokine receptor sharing 48% identity with CC-chemokine receptor (CCR)4 and 44% identity with CCR1. It displays four extracellular cysteines that are conserved among all other chemokine receptors. ChemR1 transcripts were detected by Northern blotting in the T lymphoblastic cell lines Jurkat and MOLT-4, but not in the pre-B lymphoblastic cell line JM-1. ChemR1 receptor transcripts were also detected by reverse transcription and polymerase chain reaction analysis in unstimulated CD4+ and CD8+ T cells and polymorphonuclear cells prepared from peripheral blood. The chromosomal localization was performed by radiation hybrid mapping and testing of a panel of yeast artificial chromosome clones. This allowed the assignment of the ChemR1 receptor gene to the p21.3-24 region of human chromosome 3, in close proximity with the functionally characterized CCR. Future work is required to identify the ligand(s) of this new chemokine receptor and to define its role in the recruitment of white blood cell populations.
The Chemistry of Lignin. (1934)

ADVERTISEMENT RETURN TO ISSUEPREVArticleThe Chemistry of Lignin.Max. PhillipsCite this: Chem. Rev. 1934, 14, 1, 103–170Publication Date (Print):February 1, 1934Publication History Published online1 May 2002Published inissue 1 February 1934https://pubs.acs.org/doi/10.1021/cr60047a005https://doi.org/10.1021/cr60047a005research-articleACS PublicationsRequest reuse permissionsArticle Views1896Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Deconvolution analysis of the scintillation camera renogram (1975)

A scintillation camera with digital data store has been used to assess renal function. Analysis of the renogram by deconvolution, using an on-line digital computer, shows promise as a means of expressing renal function in terms of tubular transit times for 123I-Hippuran.
Synthesis and Characterization of Silicon Oxycarbide Derived Nanocomposites Obtained through Ceramic Processing of TEOS/PDMS Preceramic Materials (2011)

Bulk silicon oxycarbide derived ceramic nanocomposites have been prepared by the application of the conventional ceramic processing to preceramic materials. Tetraethylortosilicate/ polydimethylsiloxane preceramic materials obtained by sol-gel process were thermally treated and attrition milled to 4 micrometers. Subsequently, the preceramic powders were pyrolized at 1100 °C to obtain silicon oxycarbide powders that were pressed and sintered at 1550 °C up to 16 hours. Silicon oxycarbide glasses obtained at 1100 °C from pyrolysis of preceramic materials consist of a Si-O-C network and a carbon like graphite phase well dispersed. At annealing temperatures higher than 1100°C silicon oxycarbide glasses undergo a rearrangement which involves a phase separation to silica and silicon carbide and a segregation of carbon like graphite phase. At these temperatures the material can be considered as a glassy matrix nanocomposite. At temperatures higher than 1500 °C the carbothermal reduction occurs with the consumption of both silica and free carbon phase. However, the nanocomposite structure is maintained but with different constituents. The silicon oxycarbide glasses obtained at 1100 °C are amorphous. However, as a result of all involving processes taken place during the ceramic process, the nanocomposites formed at 1550 °C comprise a silica matrix and nanodomains of carbon like graphite and silicon carbide both of them displaying an incipient crystallization. Structure and crystalline size evolution, from preceramic materials to silicon oxycarbide derived nanocomposites, have been determined by FT-IR and Raman spectroscopies, XRD and 29Si-MASNMR.
Identification of a 35 kD tumor-associated autoantigen in papillary thyroid carcinoma. (1996)

Despite its tendency to metastasize and grow multifocally, papillary thyroid carcinoma (PTC), the most common endocrine malignancy, usually displays an indolent clinical course. Although this behavior probably reflects the inherent low growth potential of PTC cells, it has been postulated that the striking inflammatory reaction often present in PTC represents the activation of a protective, tumor-induced immune response. In a recent immunohistochemical study, we reported that immunoglobulin (IgG) and complement (C3d, C4d and C5) are specifically deposited in PTC tumor tissue. Endeavors were then made to isolate and identify tumor-associated antigens. Immunoprecipitation employing the serum and tumor tissue of PTC patients produced two bands by SDS-PAGE, at approximately 34.5 and 35 kD, which were not present in normal thyroid tissue. Three tryptic peptides of the 35 kD band were sequenced, identifying it as a fragment of cytokeratin 1, a structural protein not normally expressed in the thyroid. The results indicate a tumor-specific antibody response against an aberrantly expressed protein in PTC.
Absolute optical ranging using low coherence interferometry (1991)

We describe a method for measuring submicrometer distances with an asymmetric fiber Michelson interferometer having an LED as a source of radiation. By measuring the phase slope of the Fourier components in the frequency domain, it is possible to locate the position of reflections with nanometer precision even in the presence of sample dispersion. The method is compatible with time domain sampling at the Nyquist rate which assures efficiency in data acquisition and processing.
Bias propagation in the autocorrelation method of linear prediction (1997)

Many low bit-rate speech coders use the autocorrelation method (ACM) to find a linear prediction model of the speech signal. A time-domain analysis of the ACM for autoregressive estimation is given. It is shown that a small bias in a reflection coefficient close to one in absolute value is propagated and prohibits an accurate estimation of further reflection coefficients. Tapered data windows largely reduce this effect, but increase the variance of the models.
Optical coherence-domain reflectometry: a new optical evaluation technique (1987)

An optical evaluation technique is described that is suitable for determining the positions and magnitudes of reflection sites within miniature optical assemblies. This method utilizes the coherence effects exhibited by a broadband optical source and is referred to as optical coherence-domain reflectometry. Background theory is given, and experimental results have demonstrated a resolution of 10 microm with an optical dynamic range of more than 100 dB.
Data-Parallel Large Vocabulary Continuous Speech Recognition on Graphics Processors (2008)

Automatic speech recognition is a key technology for enabling rich human-computer interaction in emerging applications. Hidden Markov Model (HMM) based recognition approaches are widely used for modeling the human speech process by constructing probabilistic estimates of the underlying word sequence from an acoustic signal. High-accuracy speech recognition, however, requires complex models, large vocabulary sizes, and exploration of a very large search space, making the computation too intense for current personal and mobile platforms. In this paper, we explore opportunities for parallelizing the HMM based Viterbi search algorithm typically used for large-vocabulary continuous speech recognition (LVCSR), and present an efficient implementation on current many-core platforms. For the case study, we use a recognition model of 50,000 English words, with more than 500,000 word bigram transitions, and one million hidden states. We examine important implementation tradeoffs for shared-memory single-chip many-core processors by implementing LVCSR on the NVIDIA G80 Graphics Processing Unit (GPU) in Compute Unified Device Architecture (CUDA), leading to significant speedups. This work is an important step forward for LVCSR-based applications to leverage many-core processors in achieving real-time performance on personal and mobile computing platforms.
The Use of Intradiscal Steroid Therapy for Lumbar Spinal Discogenic Pain (2004)

This study demonstrates that intradiscal steroid injections do not improve the clinical outcome in patients with discogenic back pain compared with placebo.
Chronic Progressive Cardiac Dysfunction Years After Doxorubicin Therapy for Childhood Acute Lymphoblastic Leukemia (2005)

Cardiac abnormalities were persistent and progressive after doxorubicin therapy. Inadequate ventricular mass with chronic afterload excess was associated with progressive contractile deficit and possibly reduced cardiac output and restrictive cardiomyopathy. The deficits were worst after highest cumulative doses of doxorubicin, but appeared even after low doses.
Elatosides A and B, potent inhibitors of ethanol absorption in rats from the bark of Aralia elata SEEM.: The structure-activity relationships of oleanolic acid oligoglycosides. (1993)

By monitoring the inhibitory effect on ethanol absorption in rats, new active saponins named elatosides A and B were isolated from the bark of Aralia elata Seem. together with elatosides C and D. The structures of elatosides A, B, C, and D were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of several oleanolic acid oligoglycosides on ethanol absorption have been examined and some structure-activity relationships have been found.
Fibrin and Fibrinogen-Related Antigens in Patients with Stable and Unstable Coronary Artery Disease (1987)

Coronary-artery thrombosis may be important in the pathogenesis of unstable angina at rest. To study this possibility, we measured the serum concentrations of fibrin-related antigen, D dimer (the principal breakdown fragment of fibrin), and fibrin monomer (an intermediate product of fibrin formation) in the serum of five groups of subjects. These included 10 healthy controls, 10 controls with noncardiac pain, and three groups of 10 patients each with chronic stable angina, unstable angina at rest, or acute myocardial infarction. The concentration of fibrin-related antigen (normal range, 48 to 184 ng per milliliter) was normal in the control patients with noncardiac pain (63 to 202 ng per milliliter) and in patients with chronic stable angina (95 to 186), but it was increased in patients with unstable angina (401 to 2507) or acute myocardial infarction (470 to 1930) (P less than 0.001). D dimer concentrations in patients with unstable angina (178.3 to 310.6 ng per milliliter) or acute myocardial infarction (103.9 to 321.6) were higher than those in patients with chronic stable angina (28.6 to 52.1), in controls with noncardiac pain (44.7 to 53.1), and in healthy controls (40.4 to 50.3) (P less than 0.001). Concentrations of fibrin monomer were highest in patients with acute myocardial infarction (247.5 to 571.3 ng per milliliter) (P less than 0.001), intermediate in those with unstable angina (54.7 to 241.7) (P less than 0.001), and normal (normal range, 14.5 to 19.8 ng per milliliter) in controls with noncardiac pain (12.0 to 18.4). and patients with chronic stable angina (10.7 to 17.6). These findings suggest the presence of an active thrombotic process in patients with unstable angina at rest or acute myocardial infarction. The data do not prove that the coronary arteries were the site of the thrombotic process, but the observations are consistent with the hypothesis that thrombus formation may have an important role in the pathogenesis of these conditions.