gebhart/patrepeval huggingface dataset:
Donor‐derived infections and infectious risk in xenotransplantation and allotransplantation (2018)

Post-transplantation infections are common in allograft recipients and should be expected in all immunocompromised hosts. Based on the need for immunosuppression in xenotransplantation, procedures developed to enhance safety in allotransplantation can be applied in future xenotransplantation clinical trials. Standardized approaches can be developed to guide the evaluation of common infectious syndromes in xenograft recipients. The opportunity created by screening of swine intended as xenograft donors has equal applicability to allotransplantation-notably broader screening strategies for allograft donors such as use of advanced sequencing modalities including broad-range molecular probes, microarrays, and high-throughput pyrosequencing. Considerations in management of allotransplant- and xenotransplant-associated infections are largely the same. Experience in xenotransplantation will continue to inform thinking regarding donor-derived infections in allotransplantation. We expect that experience in managing complex allotransplant recipients will similarly inform clinical trials in xenotransplantation.
Radical polymerization of 4-tert-butylcyclohexyl methacrylate: polymerization kinetics and polymer properties (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical polymerization of 4-tert-butylcyclohexyl methacrylate: polymerization kinetics and polymer propertiesAkikazu Matsumoto, Keiichiro Mizuta, and Takayuki OtsuCite this: Macromolecules 1993, 26, 7, 1659–1665Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ma00059a026https://doi.org/10.1021/ma00059a026research-articleACS PublicationsRequest reuse permissionsArticle Views342Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mining the Deep Seabed: A Range of Perspectives (1979)

Introduction to the symposium entitled: Mining the Deep Seabed: A Range of Perspectives. The introduction is written by Roger H. Hull, who introduces the panel, people in attendance, and core issues involving the system of exploration and exploitation for the the deep seabed resource policy, financial arrangements, and the structure of the Authority, which all parties agree will play a major role in the development of the deep seabed.
Production of doubled haploid wheat lines (Triticum aestivum L.) using anther culture technique (2011)

Anther culture response of six wheat genotypes and their F1 crosses was investigated. Results indicated that considerable genetic variation among the tested genotypes was observed. Calli were obtained from all wheat genotypes studied. The percentage of anthers that developed calli ranged from 0.67% for Gemmeiza-9 to 18.00% for the cross (Gemmeiza-7 × Sids-4). Plants were regenerated from 19 out of 21 wheat genotypes. The highest frequencies of green plantlets were achieved from the two crosses (Giza-164 × Gemmiza-9 and Giza-164 × Line-115), while the lowest ones were obtained in the cross (Giza-164 × Sids-4). Generally, crosses showed a better response in anther culture than their parental genotypes. Significant and positive heterotic effects were observed in some crosses for callus induction and green plant regeneration. Ninety-four doubled haploid lines, which were derived from five F1 crosses and their respective parents were evaluated under field conditions. Some doubled haploid lines that resulted from these crosses performed well and transgressed significantly the higher-yielding parent and the check variety.
Meta-analyses of FibroTest diagnostic value in chronic liver disease (2007)

FibroTest is an effective alternative to biopsy in patients with chronic hepatitis C and B, ALD and NAFLD. The FT diagnostic value is similar for the diagnosis of intermediate and extreme fibrosis stages.
Sliding Windows and Persistence: An Application of Topological Methods to Signal Analysis (2013)

We develop in this paper a theoretical framework for the topological study of time series data. Broadly speaking, we describe geometrical and topological properties of sliding window (or time-delay) embeddings, as seen through the lens of persistent homology. In particular, we show that maximum persistence at the point-cloud level can be used to quantify periodicity at the signal level, prove structural and convergence theorems for the resulting persistence diagrams, and derive estimates for their dependency on window size and embedding dimension. We apply this methodology to quantifying periodicity in synthetic data sets, and compare the results with those obtained using state-of-the-art methods in gene expression analysis. We call this new method SW1PerS which stands for Sliding Windows and 1-dimensional Persistence Scoring.
Efficient buffer management and scheduling in a combined IntServ and DiffServ architecture: a performance study (2003)

The differentiated services (DiffServ) architecture promises the provision of QoS-enabled networks by following a simple approach that eliminates scalability concerns and which can be implemented and managed in large networks. However, for end-to-end QoS an appropriate signaling scheme, like the resource reservation protocol (RSVP), should be supported. In this combined approach, signaling messages, which are generated by hosts and interpreted by edge routers, are tunneled transparently through the DiffServ core network. The treatment of the signaling messages in the DiffServ cloud is a very important issue, since long delays in their delivery or a high percentage of drops could result in unpredictable and undesirable situations. In this paper, we define a DiffServ traffic class, herein called network control traffic class, that is used by all signaling messages travelling through the DiffServ network. We provide a simulation analysis which evaluates the key properties of the new DiffServ class including priority level, link-sharing bandwidth and link-sharing structure for an hierarchical class-based resource management mechanism referred to as class-based queuing (CBQ), employed by the DiffServ core routers.
PCR Assay for Species-Specific Identification of Bacteroides thetaiotaomicron (2000)

Bacteroides thetaiotaomicron is the second most frequently encountered species of the anaerobes isolated from clinical specimens. We developed a PCR-based assay for the rapid identification of B. thetaiotaomicron. Specific primers were based on shared amplicons of about 1.2 kb generated from B. thetaiotaomicron by randomly amplified polymorphic DNA. This 1.2-kb fragment was sequenced and then used to design a set of PCR amplification primers. This PCR generated an amplification product of 721 bp, which was unique to all 65 isolates of B. thetaiotaomicron tested. There was no amplification with isolates of other bacterial species. Restriction enzyme digestion of the amplification product and dot blot hybridization further verified the specificity of the assay. These results suggest that this PCR assay targets a nucleotide sequence that is strongly conserved in B. thetaiotaomicron. This simple and rapid PCR assay provides a rapid and accurate method for identification of B. thetaiotaomicron and shows promise for the detection of B. thetaiotaomicron in clinical samples.
Similar Islet Function in Islet Allotransplant and Autotransplant Recipients, Despite Lower Islet Mass in Autotransplants (2011)

Insulin secretion and glucose excursion were similar in allograft and autograft recipients, despite the latter group receiving less than half as many islets. Better preservation of islet mass in the autograft setting is likely related to the lack of autoimmunity, alloimmunity, and immunosuppressive drug toxicity, highlighting the potential for better outcomes in islet allotransplant for type 1 diabetes mellitus with refinements in immunosuppression.
Heterogeneous personal communications services: integration of PCS systems (1996)

Personal communications services (PCS) are being introduced to offer ubiquitous communication. In its first phase PCS consists of a plethora of systems that address cellular, vehicular, cordless phone, and a variety of other services. The integration of these different systems is referred to as "heterogeneous PCS (HPCS)". We describe the various PCS systems available and address in detail the issue of PCS systems integration. Key implementation issues for integrating PCS systems are defined and discussed.
Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective (2011)

Malnutrition is common among older persons, with important consequences increasing frailty and morbidity and reducing health expectancy. On the contrary, calorie restriction (CR, a low-calorie dietary regimen with adequate nutrition) slows the progression of age-related diseases and extends the lifespan of many species. Identification of strategies mimicking key CR mechanisms - increased mitochondrial respiration and reduced production of oxygen radicals - is a hot topic in gerontology. Dietary supplementation with essential and/or branched chain amino acids (BCAAs) exerts a variety of beneficial effects in experimental animals and humans and has been recently demonstrated to support cardiac and skeletal muscle mitochondrial biogenesis, prevent oxidative damage, and enhance physical endurance in middle-aged mice, resulting in prolonged survival. Here we review recent studies addressing the possible role of BCAAs in energy metabolism and in the longevity of species ranging from unicellular organisms to mammals. We also summarize observations from human studies supporting the exciting hypothesis that dietary BCAA enriched mixture supplementation might be a health-promoting strategy in aged patients at risk.
Mannose‐Binding Lectin Is a Critical Factor in Systemic Complement Activation during Meningococcal Septic Shock (2009)

This indicates that MBL is critical for the systemic activation of complement seen during meningococcal septic shock.
Controlling the fluorescence of ordinary oxazine dyes for single-molecule switching and superresolution microscopy (2009)

Fluorescent molecular switches have widespread potential for use as sensors, material applications in electro-optical data storages and displays, and superresolution fluorescence microscopy. We demonstrate that adjustment of fluorophore properties and environmental conditions allows the use of ordinary fluorescent dyes as efficient single-molecule switches that report sensitively on their local redox condition. Adding or removing reductant or oxidant, switches the fluorescence of oxazine dyes between stable fluorescent and nonfluorescent states. At low oxygen concentrations, the off-state that we ascribe to a radical anion is thermally stable with a lifetime in the minutes range. The molecular switches show a remarkable reliability with intriguing fatigue resistance at the single-molecule level: Depending on the switching rate, between 400 and 3,000 switching cycles are observed before irreversible photodestruction occurs. A detailed picture of the underlying photoinduced and redox reactions is elaborated. In the presence of both reductant and oxidant, continuous switching is manifested by "blinking" with independently controllable on- and off-state lifetimes in both deoxygenated and oxygenated environments. This "continuous switching mode" is advantageously used for imaging actin filament and actin filament bundles in fixed cells with subdiffraction-limited resolution.
Evaluation of Homogeneous Options: Effects of Minor Actinide Exclusion from Single and Double Tier Recycle in Sodium Fast Reactors (2008)

The Systems Analysis Campaign under the Global Nuclear Energy Partnership (GNEP) has requested the fuel cycle analysis group at the Idaho National Laboratory (INL) to analyze and provide isotopic data for four scenarios in which different strategies for Minor Actinides (MA) management are investigated. A 1000 MWth commercial-scale Sodium Fast Reactor (SFR) design was selected as the baseline in this scenario study. Two transuranic (TRU) conversion ratios, defined as the ratio of the amount of TRU produced over the TRU destroyed in the reactor core, along with different fuel-types were investigated.
Filtration in the Biopharmaceutical Industry (1998)

TYPES OF FILTERSFilter Aid Filtration, G.R. S. SmithExpanded Polytetrafluoroethylene Membranes and Their Applications, M. Wikol, C. Bailey, K. Lange, M. Sutsko, and K. TrontoCharge-Modified Filter Media, R.A. Knight and E.A. OstreicherPrefilter Constructions, A.C. ShucoskyCartridge Filters, P. Soelkner and J. RuppFILTER CHARACTERIZATIONQuality Assurance of Filters for Fluid Clarification, H.B. KatzThe Determination of the Pore Size of Fine Filtration Media, C.T. BadenhopExtractables and Compatibilities of Filters, O.W. ReifUTILITARIAN CONSIDERATIONSBacterial Biofilms in Pharmaceutical Water Systems, M.W. MittelmanFiltrative Particle Removal from Liquids, M.W. Jornitz and T.H. MeltzerIntegrity Testing, M.W. Jornitz, A.M. Trotter, and T.H. MeltzerSizing Microporous Membrane Filter Systems, H. Green and L.A. ScheerFilter Housing Materials and Surface Finish, J. GullifordFilter Housings for Biotechnology and Pharmaceutical Applications, S.. TarryAPPLICATIONSDetection and Measurement of Particles in Pharmaceutical Liquids, A. LiebermanCrossflow Ultrafiltration, M. Dosmar and D. BroseProtein Adsorption in Microporous Membrane Filtration, S. SunderamMicrobial Retention Testing in the Validation of Sterilizing Filtration, J. Carter and R.LevyLimulus Amebocyte Lysate Assays and Filter Applications, M.J. GouldFiltration and the Removal of Viruses from Biopharmaceuticals, R.V. Levy, M. Phillips, and H. LutzAspects of Air and Gas Filtration in the Biopharmaceutical Industry, M.W. JornitzAir Filtration Applications in the Pharmaceutical Industry, H. HaughneySterility Testing with Membrane Filters, W.P. OlsonNew Membrane-Based Technologies for the Pharmaceutical Industry, T. Alex and H. HaughneyPrefiltration Technology, F. BadmingtonThe Filtration of Blood and Blood Fractions, W. P. OlsonREGULATORY CONSIDERATIONSThe Operation of the FDA: A Brief Summary, A.C. CelesteValidation of the Counting Accuracy of Particle Counters with the New Particle Counting Model, J.Z. KnappValidation of Filtrative Sterilizations, M.W. Jornitz and T.H. Meltzer
[TNF blockade in rheumatoid arthritis can cause severe fibrosing alveolitis. Six case reports]. (2006)

Virtualized servers run a diverse set of virtual machines (VMs), ranging from interactive desktops to test and development environments and even batch workloads. Hypervisors are responsible for multiplexing the underlying hardware resources among VMs while providing them the desired degree of isolation using resource management controls. Existing methods provide many knobs for allocating CPU and memory to VMs, but support for control of IO resource allocation has been quite limited. IO resource management in a hypervisor introduces significant new challenges and needs more extensive controls than in commodity operating systems.This paper introduces a novel algorithm for IO resource allocation in a hypervisor. Our algorithm, mClock, supports proportional-share fairness subject to minimum reservations and maximum limits on the IO allocations for VMs. We present the design of mClock and a prototype implementation inside the VMware ESX server hypervisor. Our results indicate that these rich QoS controls are quite effective in isolating VM performance and providing better application latency. We also show an adaptation of mClock (called dmClock) for a distributed storage environment, where storage is jointly provided by multiple nodes.
Proprioception based behavioral advances in a hexapod robot (2002)

We report on our progress in extending the behavioral repertoire of RHex, a compliant leg hexapod robot. We introduce two new controllers, one for climbing constant slope inclinations and one for achieving higher speeds via pronking, a gait that incorporates a, substantial aerial phase. In both cases, we make use of an underlying open-loop control strategy, combined with low bandwidth feedback to modulate its parameters. The inclination behavior arises from our initial alternating tripod walking controller and adjusts the angle offsets of individual leg motion profiles based on inertial sensing of the average surface slope. Similarly, the pronking controller makes use of a "virtual" leg touchdown sensing mechanism to adjust the frequency of the open-loop pronking, effectively synchronizing the controller with the natural oscillations of the mechanical system. Experimental results demonstrate good performance on slopes inclined up to /spl sim/250 and pronking up to speeds approaching 2 body lengths per second (/spl sim/1.0 m/s).
Dynamic Proteomics of Individual Cancer Cells in Response to a Drug (2008)

Why do seemingly identical cells respond differently to a drug? To address this, we studied the dynamics and variability of the protein response of human cancer cells to a chemotherapy drug, camptothecin. We present a dynamic-proteomics approach that measures the levels and locations of nearly 1000 different endogenously tagged proteins in individual living cells at high temporal resolution. All cells show rapid translocation of proteins specific to the drug mechanism, including the drug target (topoisomerase-1), and slower, wide-ranging temporal waves of protein degradation and accumulation. However, the cells differ in the behavior of a subset of proteins. We identify proteins whose dynamics differ widely between cells, in a way that corresponds to the outcomes-cell death or survival. This opens the way to understanding molecular responses to drugs in individual cells.
C-myc oncoprotein expression and prognosis in patients with carcinoma of the cervix: an immunohistochemical study. (2002)

c-Myc nuclear immunoreactivity is a predictor of poorer response to radiotherapy and poorer disease free status in stage II B and III B carcinoma of the cervix.
A native iPhone packbot OCU (2009)

This video abstract discusses the details of the implementation of a Packbot operator control unit (OCU) using Apple's official iPhone SDK.
Implementing SMART for minicomputers via relational processing With abstract data types (1981)

Designed during the 1960's as a research tool for the field of information retrieval, the SMART system has been operating on an IBM 370 since 1974. SMART is now being enhanced, redesigned, and programmed under the UNIX operating system [28] on a DEC VAX 11/780. The techniques used should allow real-time operation on smaller minicomputers in the PDP 11 family. The implementation provides for a combination of database and information retrieval operations which make it applicable to office automation, personal information system management, and research studies. The SMART vector space model, which treats information requests and stored information records as vectors in an n-space (of terms), is integrated into the relational database model using the concepts of abstract data types (ADTs). Domains of relations are allowed to be any ADT; an extended relational algebra is described with operators that manipulate many complex data structures. After illustrating the application of these concepts to typical SMART tasks, a prototype implementation is outlined. Also included is a discussion of techniques to be employed in a more efficient version.
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. (1999)

Telomerase activation is thought to be a critical step in cellular immortalization and carcinogenesis. Of the three major subunits comprising human telomerase, human telomerase catalytic subunit (hTERT) has been shown to be a rate-limiting determinant of the enzymatic activity of human telomerase. However, little is known concerning how expression of hTERT is regulated in human cells. To identify the regulatory elements controlling hTERT gene expression, approximately 3.5 kb of the 5'-flanking sequence of hTERT was cloned and characterized. The promoter of hTERT was GC rich and lacked both TATA and CAAT boxes. The CapSite Hunting method identified transcription start site 19 bp upstream of the first nucleotide of the published cDNA sequence. Transient expression assays revealed that transcription of hTERT was significantly activated in cancer cell lines but repressed in normal primary cells. Using the fibroblast lineage at various stages of transformation, we found that transcription occurred in strains that had overcome replicative senescence and expressed telomerase activity. Deletion analysis of hTERT promoter identified the 181-bp core promoter region upstream of the transcription start site. Gel shift analysis revealed two major factors binding to core promoter, an E box (CACGTG) binding factor and Sp1. Overexpression of c-Myc resulted in a significant increase in transcriptional activity of the core promoter. These findings suggest that hTERT expression is strictly regulated at the transcription machinery, and that the proximal core promoter containing an E box and Sp1 sites is required for transactivation of hTERT.
Recent developments in breast imaging (1996)

A review of breast imaging has already appeared in 1982 in this journal. Consequently, the present article concentrates on a discussion of only those developments of a more recent nature. Although the emphasis is placed on the physical aspects of the different imaging methods concerned, the essential factors relating to the clinical background and the associated radiation risk are also outlined. The completeness of detail depends on the present clinical importance of the method under discussion. X-ray mammography, which is still the most important breast imaging technique and has proved to be an effective method for breast cancer screening, is therefore treated in greater detail. Since the early 1980s, ultrasound B-mode scanning has evolved to an indispensable adjunct to x-ray mammography. For Doppler sonography, diaphanography, contrast-enhanced MRI, CT and DSA, the visualization of a tumour depends essentially on the enhanced vascularity of the lesion. Whether this will prove to be a reliable indicator for malignancy remains to be shown in controlled clinical studies. Common to all imaging systems is the increasing use of digital methods for signal processing, which also offers the possibility of computer-aided diagnosis by texture analysis and pattern recognition.