gebhart/patrepeval huggingface dataset:
The Process and Model Innovation of Ideological Education Network Communication in Colleges and Universities Based on Cloud Computing (2021)

The purpose is to improve the power and innovate the communication mode of mainstream I&amp;P (Ideological and Political) education in C&amp;U (Colleges and Universities). The opportunities and challenges that I&amp;P education is facing or will face in media times are analyzed from three factors: the subjective, the mediator, and the environment, which affect the power of mainstream I&amp;P in C&amp;U. Educational means, carriers, resources, places and times, and the interactions between educators and the educated can bring opportunities for the improvement of the educational power of C&amp;U. However, there are great challenges in all aspects of the mainstream ideology, such as education methods, education ideas, education content, education leadership and discourse power, and network public opinion control. Finally, a series of measures are proposed to improve the power of mainstream I&amp;P education in C&amp;U in media times, and they are updating the concept of media education, strengthening the ideological guidance, ensuring the direction of mainstream I&amp;P education, and optimizing the media environment so that a more perfect innovative mode of I&amp;P education is constructed. The research enriches and develops the theory of mainstream I&amp;P education in C&amp;U, innovates the methods of mainstream I&amp;P education in C&amp;U, and enhances the power of mainstream I&amp;P education.
Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. (2000)

Gastrin is a growth factor for colorectal cancer, and therefore, anti-gastrin hormone therapy has a potential role in treatment of this disease. The gastrin immunogen gastrin-17-diphtheria toxoid (G17-DT; Gastrimmune) produces anti-G17 antibodies that have been shown to be effective in the treatment of colorectal carcinoma in preclinical models. Fifty patients with advanced colorectal cancer were treated with G17-DT in a multicenter, sequential group, open label Phase I/II study. Primary injections with two booster doses were given by i.m. injection. The main aim of the study was to assess the safety and efficacy of the production of antigastrin antibodies. Locally developed and standard WHO toxicity measurements with RIA and Scatchard analysis for antibody assessment were used. One center measured tumor response radiologically. Eighty % of patients produced a measurable antibody response. Antibodies of high affinity (median Kd, 0.295 nM; interquartile range, 0.16-0.41 nM) were detected between 4 and 12 weeks after primary injection. The antigen binding capacity was high at 2.8 x 10(-9) M (interquartile range, 5.1 x 10(-10) to 7.25 x 10(-9) M). The treatment was well tolerated with no systemic side effects seen. Myalgia at the injection site was seen in 46% of patients with severe pain caused by the formation of a sterile abscess seen in 14% of patients. The abscesses were all drained under ultrasound guidance, and the patients recovered fully within 6 weeks. No radiological responses were seen, but two patients had stable disease. G17-DT immunization produces anti-G17 antibodies in patients with advanced colorectal cancer. The antibodies were of an affinity high enough to compete with the cholecystokinin B/gastrin receptor for G17 binding with adequate capacity to neutralize postprandial gastrin surges. Additional dose-ranging studies have been performed in patients with gastric cancer using 100- and 200-microg doses of G17-DT formulated without adjuvant and the emulsifier aluminum monostearate. In addition, the effect of immunizing at different time intervals has been determined.
Quantum size effect and supercontinuum of fabricated inner cladding fibres with InP nano thin films (2009)

Based on the hydrogen atomic model, the InP, one kind of semiconductor materials Boer exciton radius have been calculated. The comparative size of the InP particle is a B =8.313nm. This article used improved chemistry vapour deposition and drawn out the fibres with InP nano thin films. By the quantum size effect, the change of the energy band of particles with different sizes and light absorption wavelength has been calculated. By using test system and nonlinear effect of fibre, supercontinuum generation can be obtained from fibres with InP nano thin films.
A wireless telecommunications network for real-time monitoring of greenhouse microclimate (2014)

An innovative wireless monitoring system for measuring greenhouse climatic parameters was developed to overcome the problems related to wires cabling such as presence of a dense net of wires hampering the cultivation practices, wires subjected to high temperature and relative humidity, rodents that can damage wires. The system exploits battery-powered environmental sensors, such as air temperature and relative humidity sensors, wind speed and direction, and solar radiation sensors, integrated in the contest of an 802.15.4-based wireless sensors network. Besides, a fruit diameter measurement sensor was integrated into the system. This approach guarantees flexibility, ease of deployment and low power consumption. Data collected from the greenhouse are then sent to a remote server via a general packet radio service link. The proposed solution has been implemented in a real environment. The test of the communication system showed that 0.3% of the sent data packed were lost; the climatic parameters measured with the wireless system were compared with data collected by the wired system showing a mean value of the absolute difference equal to 0.6°C for the value of the greenhouse air temperature. The wireless climate monitoring system showed a good reliability, while the sensor node batteries showed a lifetime of 530 days.
Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. (1984)

The transforming gene of malignant melanoma tissue obtained from a Japanese patient and maintained in nude mice has been cloned in its biologically active form and identified as the c-Ha-ras-1 gene, a homologue of the viral Ha-ras gene. Nucleotide sequence analysis revealed that the genetic alteration responsible for the transforming activity of the melanoma oncogene was localized to a single point mutation in the second exon. The transversion of adenine to thymine results in the substitution of leucine for glutamine as amino acid residue 61 of the predicted p21 protein. Other nucleotide sequences spanning a 2.9-kilobase segment including the entire exons and introns were found to be exactly the same as those in a proto-oncogene from a normal Caucasian reported previously, except for base alterations explained as polymorphic differences.
Identification of proliferating dendritic cell precursors in mouse blood. (1992)

While it has been known that dendritic cells arise from proliferating precursors in situ, it has been difficult to identify progenitors in culture. We find that aggregates of growing dendritic cells develop in cultures of mouse blood that are supplemented with granulocyte/macrophage colony-stimulating factor (GM-CSF) but not other CSFs. The dendritic cell precursor derives from the Ia-negative and nonadherent fraction. The aggregates of developing dendritic cells appear at about 1 wk of culture, with 100 or more such clusters being formed per 10(6) blood leukocytes. The aggregates can be dislodged and subcultured as expanding clusters that are covered with cells having the motile sheet-like processes ("veils") of dendritic cells. By about 2 wk, large numbers of single, major histocompatibility complex (MHC) class II-rich dendritic cells begin to be released into the medium. Combined immunoperoxidase and [3H]thymidine autoradiography show that the cells that proliferate within the aggregate lack certain antigenic markers that are found on mature dendritic cells. However, in pulse-chase protocols, the [3H]thymidine-labeled progeny exhibit many typical dendritic cell features, including abundant MHC class II and a cytoplasmic granular antigen identified by monoclonal antibody 2A1. The progeny dendritic cells are potent stimulators of the mixed leukocyte reaction and can home to the T-dependent areas of lymph node after injection into the footpads. We conclude that mouse blood contains GM-CSF-dependent, proliferating progenitors that give rise to large numbers of dendritic cells with characteristic morphology, mobility, phenotype, and strong T cell stimulatory function.
SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity. (1998)

SHP-1 protein tyrosine phosphatase is a critical regulator of signal transduction in hematopoietic cells. In the present study, we derived two pre-B cell lines, PBCL-1 and PBCL-2, from normal and SHP-1-deficient motheaten mice, respectively, and characterized hyperphosphorylated proteins in PBCL-2 cells to identify SHP-1-regulated molecules. Two proteins of 56 and 53 kDa (p56/p53) in PBCL-2 cells showed heightened phosphorylation (3- to 6-fold) in comparison with those in PBCL-1. p56/p53 were identified as the two forms of the lyn protein tyrosine kinase (p56/p53lyn), which showed increased kinase activity in PBCL-2 cells. Interestingly, the protein levels of p56/53lyn were found to be 3- to 6-fold higher in PBCL-2 cells than those in PBCL-1, whereas the transcript levels of lyn in the two cell lines were comparable. A modest increase in p56/53lyn protein expression was also detected in primary spleen B cells of motheaten mice. Thus SHP-1 deficiency in B-lineage cells, especially pre-B cells, is associated with increased lyn protein expression and kinase activity. These data indicate a role for SHP-1 in regulating lyn through a post-transcriptional mechanism.
Severe Congenital Factor X Deficiency in 5-Month-Old Child (1970)

Summary A case of severe congenital factor X deficiency is presented. The patient was a 5 month old child who had several episodes of melena since the first weeks of life. Other bleeding manifestations were subcutaneous hematomas and a massive brain hemorrhage. The prothrombin time was severely prolonged and was corrected by normal serum, aged normal plasma and by the plasma of patients with parahemophilia, congenital hypoprothrombinemia and factor VII deficiency. On the contrary adsorbed normal plasma and Mr. Stuart’s plasma failed to correct the abnormality. The partial thromboplastin time, prothrombin consumption and the thromboplastin generation test were abnormal too. The T.G.T. was corrected by the substitution of the patient’s serum with normal serum. The factor X level was less then 0.1% of normal. All other clotting factors were within normal limits. Both parents of the “propositus” showed slightly decreased levels of factor X in their plasmas and were considered to be heterozygotes for the defect.
Novel synthesis of 2-naphthols; phenanthrols, anthracenes, and other polycyclic aromatic products (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel synthesis of 2-naphthols; phenanthrols, anthracenes, and other polycyclic aromatic productsDonald L. FieldsCite this: J. Org. Chem. 1971, 36, 20, 3002–3005Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/jo00819a020https://doi.org/10.1021/jo00819a020research-articleACS PublicationsRequest reuse permissionsArticle Views213Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome (1992)

The erythrocytes from a patient with Scott syndrome, a bleeding disorder characterized by an isolated defect in expression of platelet procoagulant activity, have been studied. When incubated with the calcium ionophore A23187, Scott syndrome red blood cells (RBCs) expressed less than 10% of the prothrombinase (enzyme complex of coagulation factors Va and Xa) activity of A23187-treated RBCs obtained from normal controls. Consistent with the results from enzyme assay, the ionophore-treated Scott syndrome erythrocytes exhibited diminished membrane vesiculation and decreased exposure of membrane binding sites for factor Va compared with identically treated controls. When examined by scanning electron microscopy, untreated Scott syndrome RBCs were indistinguishable from normal cells. After incubation with A23187, however, the morphology of Scott syndrome RBCs contrasted markedly from normal erythrocytes. Whereas the Ca2+ ionophore induced marked echinocytosis and spiculation of normal RBCs, Scott syndrome RBCs remained mostly discoid under these conditions, with only an occasional echinocyte-like cell observed. These aberrant responses to intracellular Ca2+ were also observed for resealed ghosts prepared from Scott syndrome erythrocytes, indicating that they are related to a defect in the membrane or membrane-associated cytoskeleton. The finding that the erythrocytes of this patient share many of the membrane abnormalities reported previously for Scott syndrome platelets suggests that this defect is common to both cell lines and involves a membrane component required for vesicle formation and for expression of prothrombinase sites.
Magnetic particle imaging using a field free line (2008)

This paper presents a simulation study on the use of a field free line in magnetic particle imaging. A major improvement in the image quality is demonstrated. The reason for this image quality improvement is discussed, and routes for the technical implementation of the effect are sketched.
Identification of bifunctional Δ12/ω3 fatty acid desaturases for improving the ratio of ω3 to ω6 fatty acids in microbes and plants (2006)

We report the identification of bifunctional Delta12/omega3 desaturases from Fusarium moniliforme, Fusarium graminearum, and Magnaporthe grisea. The bifunctional activity of these desaturases distinguishes them from all known Delta12 or omega3 fatty acid desaturases. The omega3 desaturase activity of these enzymes also shows a broad omega6 fatty acid substrate specificity by their ability to convert linoleic acid (LA), gamma-linolenic acid, di-homo-gamma-linolenic acid, and arachidonic acid to the omega3 fatty acids, alpha-linolenic acid (ALA), stearidonic acid, eicosatetraenoic acid, and eicosapentaenoic acid (EPA), respectively. Phylogenetic analysis suggests that omega3 desaturases arose by independent gene duplication events from a Delta12 desaturase ancestor. Expression of F. moniliforme Delta12/omega3 desaturase resulted in high ALA content in both Yarrowia lipolytica, an oleaginous yeast naturally deficient in omega3 desaturation, and soybean. In soybean, seed-specific expression resulted in 70.9 weight percent of total fatty acid (%TFA) ALA in a transformed seed compared with 10.9%TFA in a null segregant seed and 53.2%TFA in the current best source of ALA, linseed oil. The ALA/LA ratio in transformed seed was 22.3, a 110- and 7-fold improvement over the null segregant seed and linseed oil, respectively. Thus, these desaturases have potential for producing nutritionally desirable omega3 long-chain polyunsaturated fatty acids, such as EPA, with a significantly improved ratio of omega3/omega6 long-chain polyunsaturated fatty acids in both oilseeds and oleaginous microbes.
Fundamentals of Neurologic Disease (2005)

Preface Acknowledgments Foreword 1 Approach to the patient with neurologic problem: key steps in neurological diagnosis and treatment 2 Neurologic examination 3 Common neurologic tests 4 Disorders of muscle 5 Disorders of the neuromuscular junction 6 Disorders of peripheral nerves 7 Disorders of the spinal cord and vertebral bodies 8 Disorders of the brainstem and cerebellum 9 Disorders of the cerebrovascular system 10 Disorders of myelin 11 Disorders of higher cortical function 12 Disorders of the extrapyramidal system 13 Infections of the Nervous System 14 Brain tumors 15 Seizures and status epilepticus 16 Cardiac arrest, coma and cerebral death 17 Disorders of the developing nervous system 18 Traumatic brain injury and subdural hematoma 19 Neurologic complications of alcohol and B12 deficiency 20 Disorders of pain and headache 21 Disorders of the vestibular system 22 Sleep
Structural models of primary cell walls in flowering plants: consistency of molecular structure with the physical properties of the walls during growth (1993)

Advances in determination of polymer structure and in preservation of structure for electron microscopy provide the best view to date of how polysaccharides and structural proteins are organized into plant cell walls. The walls that form and partition dividing cells are modified chemically and structurally from the walls expanding to provide a cell with its functional form. In grasses, the chemical structure of the wall differs from that of all other flowering plant species that have been examined. Nevertheless, both types of wall must conform to the same physical laws. Cell expansion occurs via strictly regulated reorientation of each of the wall's components that first permits the wall to stretch in specific directions and then lock into final shape. This review integrates information on the chemical structure of individual polymers with data obtained from new techniques used to probe the arrangement of the polymers within the walls of individual cells. We provide structural models of two distinct types of walls in flowering plants consistent with the physical properties of the wall and its components.
Binaural processing model based on contralateral inhibition. III. Dependence on temporal parameters (2001)

This paper and two accompanying papers [Breebaart et al., J. Acoust. Soc. Am. 110, 1074–1088 (2001); 110, 1089–1104 (2001)] describe a computational model for the signal processing of the binaural auditory system. The model consists of several stages of monaural and binaural preprocessing combined with an optimal detector. Simulations of binaural masking experiments were performed as a function of temporal stimulus parameters and compared to psychophysical data adapted from literature. For this purpose, the model was used as an artificial observer in a three-interval, forced-choice procedure. All model parameters were kept constant for all simulations. Model predictions were obtained as a function of the interaural correlation of a masking noise and as a function of both masker and signal duration. Furthermore, maskers with a time-varying interaural correlation were used. Predictions were also obtained for stimuli with time-varying interaural time or intensity differences. Finally, binaural forward-masking conditions were simulated. The results show that the combination of a temporal integrator followed by an optimal detector in the time domain can account for all conditions that were tested, except for those using periodically varying interaural time differences (ITDs) and those measuring interaural correlation just-noticeable differences (jnd’s) as a function of bandwidth.
Fast quantizing and decoding and algorithms for lattice quantizers and codes (1982)

For each of the lattices <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">A_{n}(n \geq 1), D_{n}(n \geq 2), E_{6}, E_{7}, E_{8}</tex> , and their duals a very fast algorithm is given for finding the closest lattice point to an arbitrary point. If these lattices are used for vector quantizing of uniformly distributed data, the algorithm finds the minimum distortion lattice point. If the lattices are used as codes for a Gaussian channel, the algorithm performs maximum likelihood decoding.
Relaxed InxGa1−xAs graded buffers grown with organometallic vapor phase epitaxy on GaAs (1998)

In x Ga 1−x As structures with compositionally graded buffers were grown with organometallic vapor phase epitaxy on GaAs substrates and characterized with plan-view and cross-sectional transmission electron microscopy, atomic force microscopy, and x-ray diffraction. The results show that surface roughness experiences a maximum at growth temperatures where phase separation occurs in InxGa1−xAs. The strain fields from misfit dislocations induce this phase separation in the 〈110〉 directions. At growth temperatures above and below this temperature, the surface roughness is decreased significantly; however, only growth temperatures above this regime ensure nearly complete relaxed graded buffers with the most uniform composition caps. With the optimum growth temperature for grading InxGa1−xAs determined to be 700 °C, it was possible to produce In0.33Ga0.67As diode structures on GaAs with threading dislocation densities &amp;lt;8.5×106/cm2.
The Hepatitis C Virus Alternate Reading Frame (ARF) and Its Family of Novel Products: The Alternate Reading Frame Protein/F-Protein, the Double-Frameshift Protein, and Others (2005)

The hepatitis C virus (HCV) has an alternate reading frame (ARF) that overlaps the core protein gene. The overlapping reading frame distinguishes HCV from all of its known viral relatives, with the possible exception of GB virus B (GBV-B). The ARF is expressed during natural HCV infections and stimulates specific immune responses. Like several essential genes in other viruses (e.g., the human immunodeficiency virus polymerase) the ARF lacks an in-frame AUG start codon, suggesting that its expression involves unusual translation-level events. In vitro studies indicate that ribosomal frameshifting may be one of several processes that can lead to translation of the ARF. Frameshifting yields chimeric proteins that have segments encoded in the core gene covalently attached to amino acids encoded in the ARF. A consistent nomenclature for the ARF's protein products has yet to be established. We propose that all proteins that contain amino acids encoded in the + 1 ARF be called alternate reading frame proteins (ARFPs) and that specific ARFPs, such as the ARFP/F-protein, the double-frameshift protein, and the short form of core + 1, be designated as follows: ARFP/F (ARFP/F-protein), ARFP/DF (double-frameshift), and ARFP/S (short form of core + 1). The roles of ARFPs in the HCV life cycle are not yet known. There is a significant possibility that ARFPs may be responsible for some of the effects attributed to the core protein, given that most studies seeking to define the function of the core protein have employed materials likely to contain a combination of the core protein and ARFPs. The observed effects of the core protein include the induction of liver cancer, transformation of cells, and alterations of immune responses. This article reviews the discovery of ARF, describes the RNA structural elements involved in core/ARF gene expression, discusses possible functions of ARFPs, and considers the potential usefulness of ARFPs in vaccines. The HCV ARF is the focus of a new and rapidly expanding area of research, and the results of many ongoing studies are currently available in abstract form only. The preliminary nature of investigations that have not yet been reviewed by peers is noted in the text.