gebhart/patrepeval huggingface dataset:
Effect of linkage variation on pharmacokinetics of ricin A chain-antibody conjugates in normal rats. (1986)

We have investigated the pharmacokinetics of three ricin A chain-antibody conjugates having different bridging structures. Conjugate 1 has a disulphide linkage and was prepared with the N-succinimidyl-3-(2-pyridyldithio)propionate cross-linking reagent. Conjugate 2 has a protected disulphide linkage with a methyl group substituted on the carbon atom of the bridging structure adjacent to the disulphide linkage. Its preparation necessitated the synthesis of a new cross-linking reagent N-succinimidyl 3-(2-pyridyldithio)-butyrate. Conjugate 3 has a sulphide linkage and was prepared with the cross-linking reagent N-succinimidyl 4-(iodoacetylamino)benzoate which was synthesized by a novel route. Conjugate 1 is reducible, conjugate 2 less easily reducible and conjugate 3 nonreducible. On administration to animals all three conjugates displayed biphasic kinetics. The reducibility of the bond had no significant effect on the early disappearance of the conjugate from the circulation. However, at the later time points ease of reduction of the bond was associated with a more rapid disappearance of conjugate.
Tubular Microbial Fuel Cells for Efficient Electricity Generation (2005)

A tubular, single-chambered, continuous microbial fuel cell (MFC) that generates high power outputs using a granular graphite matrix as the anode and a ferricyanide solution as the cathode is described. The maximal power outputs obtained were 90 and 66 W m(-3) net anodic compartment (NAC) (48 and 38 W m(-3) total anodic compartment (TAC)) for feed streams based on acetate and glucose, respectively, and 59 and 48 W m(-3) NAC for digester effluent and domestic wastewater, respectively. For acetate and glucose, the total Coulombic conversion efficiencies were 75 +/- 5% and 59 +/- 4%, respectively, at loading rates of 1.1 kg chemical oxygen demand m(-3) NAC volume day(-1). When wastewater was used, of the organic matter effectively removed (i.e., 22% at a loading of 2 kg organic matter m(-3) NAC day(-1)), up to 96% was converted to electricity on a Coulombic basis. The lower overall efficiency of the wastewater-treating reactors is related to the presence of nonreadily biodegradable organics and the interference of alternative electron acceptors such as sulfate present in the wastewater. To further improve MFCs, focus has to be placed on the enhanced conversion of nonrapidly biodegradable material and the better directing of the anode flow toward the electrode instead of to alternative electron acceptors. Also the use of sustainable, open-air cathodes is a critical issue for practical implementation.
A natural language planner interface for mobile manipulators (2014)

Natural language interfaces for robot control aspire to find the best sequence of actions that reflect the behavior intended by the instruction. This is difficult because of the diversity of language, variety of environments, and heterogeneity of tasks. Previous work has demonstrated that probabilistic graphical models constructed from the parse structure of natural language can be used to identify motions that most closely resemble verb phrases. Such approaches however quickly succumb to computational bottlenecks imposed by construction and search the space of possible actions. Planning constraints, which define goal regions and separate the admissible and inadmissible states in an environment model, provide an interesting alternative to represent the meaning of verb phrases. In this paper we present a new model called the Distributed Correspondence Graph (DCG) to infer the most likely set of planning constraints from natural language instructions. A trajectory planner then uses these planning constraints to find a sequence of actions that resemble the instruction. Separating the problem of identifying the action encoded by the language into individual steps of planning constraint inference and motion planning enables us to avoid computational costs associated with generation and evaluation of many trajectories. We present experimental results from comparative experiments that demonstrate improvements in efficiency in natural language understanding without loss of accuracy.
Relationship of Periodontal Disease and Edentulism to Stroke/TIA (2003)

Periodontitis has been shown to increase the systemic inflammatory response, which has been implicated in atherosclerosis and cerebrovascular events. We hypothesized an association between periodontitis or edentulism and Stroke/TIA in the ARIC Study. Data on 9415 dentate and 1491 edentulous adults included demographics, cardiovascular outcomes, lifestyle, laboratory measures, and, for 6436 of the dentate, a dental examination. The dependent variable was Stroke/TIA, and the exposure was extent (%) of attachment level 3+ millimeters (AL). Quartiles of AL and edentulism were compared for Stroke/TIA using odds ratios (OR) and 95% confidence intervals (CI), and confounders were controlled by logistic regression. Stroke/TIA was prevalent in 13.5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke/TIA.
Biodegradable polymer film as a source for formation of human fetal retinal pigment epithelium spheroids. (1999)

Biodegradable polymer films can be used as a scaffold for the adhesion of the HFRPE sheet and formation of spheroids. Spheroids represent a source of high density and well-differentiated HFRPE cells that are easy to transfer. Furthermore, the stricture of the membrane makes it suitable for additional applications.
Flexible fiberoptic endoscopy of the cochlea: human temporal bone studies. (1991)

New bone formation within the cochlea has been found more frequently than expected during cochlear implantation. Although implantation of partially ossified cochleas with long multichannel electrodes is possible, in practicality it may be difficult to determine whether electrode insertion is feasible prior to attempting it. In spite of use of high resolution computerized tomography, the presence, nature, and extent of new bone formation in the scala tympani is often difficult to ascertain. Flexible fiberoptic otologic endoscopes, 0.7 mm and 1.0 mm in diameter, were developed for the purpose of visualizing the fluid-containing scalae of the cochlea. In order to determine the efficacy of the device in visualizing the interior of the cochlea, as well as determining possible damage caused by its use, ten formalin fixed human temporal bones were studied. The flexible fiberoptic otologic endoscope was found to be capable of passage through the scala tympani of the cochlea in the inferior segment and of identifying normal and abnormal structures. Passage beyond this point resulted in damage to the spiral ligament. We conclude that human trials of use of the endoscope during cochlear implantation on previously deafened individuals is feasible.
Fine frequency tuning in resonant sensors (1994)

To realize highly sensitive resonant IR sensors the control of mechanical properties of the p+ silicon film is essential. Microfocus Raman spectroscopy and secondary ion mass spectrometry were used to measure the stress and boron concentration profile in the p+ silicon film respectively. Measurements of bending in cantilevers, of transversal stress gradient and boron profile in the films were found as being consistent with each other. Prediction of mechanical properties of micromechanical structure can be realized by using these techniques. Fine tuning of the resonance frequency in the final, packaged device, was realized by using an electrostatically activated axial force.
An Improved CO2 Separation and Purification System Based on Cryogenic Separation and Distillation Theory (2014)

In this study, an improved CO2 separation and purification system is proposed based on in-depth analyses of cryogenic separation and distillation theory as well as the phase transition characteristics of gas mixtures containing CO2. Multi-stage compression, refrigeration, and separation are adopted to separate the majority of the CO2 from the gas mixture with relatively low energy penalty and high purity. Subsequently, the separated crude liquid CO2 is distilled under high pressure and near ambient temperature conditions so that low energy penalty purification is achieved. Simulation results indicate that the specific energy consumption for CO2 capture is only 0.425 MJ/kgCO2 with 99.9% CO2 purity for the product. Techno-economic analysis shows that the total plant investment is relatively low. Given its technical maturity and great potential in large-scale production, compared to conventional MEA and SelexolTM absorption methods, the cost of CO2 capture of the proposed system is reduced by 57.2% and 45.9%, respectively. The result of this study can serve as a novel approach to recovering CO2 from high CO2 concentration gas mixtures.
Iris recognition using circular symmetric filters (2003)

Proposes a method for personal identification based on iris recognition. The method consists of three major components: image preprocessing, feature extraction and classifier design. A bank of circular symmetric filters is used to capture local iris characteristics to form a fixed length feature vector. In iris matching, an efficient approach called nearest feature line (NFL) is used. Constraints are imposed on the original NFL method to improve performance. Experimental results show that the proposed method has an encouraging performance.
DNA immunization confers systemic, but not mucosal, protection against enteroinvasive bacteria (1999)

Naked plasmid DNA (pRc/Y-hsp60) with a cytomegalovirus promoter and a sequence encoding Yersinia enterocolitica 60-kDa heat shock protein (Y-HSP60) was used for vaccination. After intramuscular injection of pRc/Y-hsp60, Y-hsp60 mRNA could be detected by reverse transcription-PCR in muscle, liver and spleen. A single immunization with pRc/Y-hsp60 induced significant Y-HSP60-specific T cell responses after 1 week. IFN-gamma production by spleen cells upon stimulation with Y-HSP60 was strictly dependent on the presence of CD4+ T cells, indicating the generation of a Th1 response upon DNA immunization. DNA immunization in addition induced strong Y-HSP60-specific IgG2a, weak IgG1, but not IgA antibodies. Immunization of BALB/c and C57BL/6 mice with pRc/Y-hsp60 conferred protection against disseminated Y. enterocolitica infection in spleen, but not at the site of mucosal entry, the Peyer's patches. Furthermore, pRc/Y-hsp60 vaccination did not induce cross-protection against related pathogens. Vaccination of beta2-microglobulin- and H2-I-Abeta-deficient mice was not protective, suggesting that both CD4+ and CD8+ T cells are required for protective immunity induced by DNA vaccination.
Computational rephotography (2010)

Rephotographers aim to recapture an existing photograph from the same viewpoint. A historical photograph paired with a well-aligned modern rephotograph can serve as a remarkable visualization of the passage of time. However, the task of rephotography is tedious and often imprecise, because reproducing the viewpoint of the original photograph is challenging. The rephotographer must disambiguate between the six degrees of freedom of 3D translation and rotation, and the confounding similarity between the effects of camera zoom and dolly. We present a real-time estimation and visualization technique for rephotography that helps users reach a desired viewpoint during capture. The input to our technique is a reference image taken from the desired viewpoint. The user moves through the scene with a camera and follows our visualization to reach the desired viewpoint. We employ computer vision techniques to compute the relative viewpoint difference. We guide 3D movement using two 2D arrows. We demonstrate the success of our technique by rephotographing historical images and conducting user studies.
Micro Total Analysis Systems. 1. Introduction, Theory, and Technology (2002)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTMicro Total Analysis Systems. 1. Introduction, Theory, and TechnologyDarwin R. Reyes, Dimitri Iossifidis, Pierre-Alain Auroux, and Andreas ManzView Author Information Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, U.K. Cite this: Anal. Chem. 2002, 74, 12, 2623–2636Publication Date (Web):May 17, 2002Publication History Published online17 May 2002Published inissue 1 June 2002https://pubs.acs.org/doi/10.1021/ac0202435https://doi.org/10.1021/ac0202435review-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views13986Altmetric-Citations1839LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amorphous materials,Biotechnology,Fluid dynamics,Genetics,Silicon Get e-Alerts
Interleukin-2 liposome inhalation therapy is safe and effective for dogs with spontaneous pulmonary metastases (1997)

Pet dogs with naturally occurring pulmonary metastases and primary lung carcinomas accepted inhalation treatments easily. Nontoxic and effective treatment of pulmonary metastases of osteosarcoma is possible with nebulized IL-2 liposomes.
Simultaneous, Sequential, and Reverse Sequential Techniques for the Preparation of Binary Silica-supported Sodium/Strontium Catalysts and the Effect of Carbon Tetrachloride on the Oxidative Coupling of Methane (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimultaneous, Sequential, and Reverse Sequential Techniques for the Preparation of Binary Silica-supported Sodium/Strontium Catalysts and the Effect of Carbon Tetrachloride on the Oxidative Coupling of MethaneR. Voyatzis and J. B. MoffatCite this: Energy Fuels 1994, 8, 5, 1106–1114Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ef00047a014https://doi.org/10.1021/ef00047a014research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase III Clinical Trial of the Combination of Cisplatin, Dacarbazine, and Carmustine With or Without Tamoxifen in Patients With Advanced Malignant Melanoma (1999)

The addition of TAM to this three-agent regimen of CDB was not found to provide a meaningful clinical advantage in the treatment of patients with advanced malignant melanoma.
A new system for continuous recurrent laryngeal nerve monitoring (2007)

Existing nerve monitoring devices in thyroid surgery are - except for one - mainly intermittently working nerve identification tools. We present a new vagal electrode which allows true continuous monitoring of the recurrent laryngeal nerve (RLN). The electrode was designed as a tripolar hybrid cuff electrode consisting of polyimide, gold and platinum layers embedded in a flexible silicon cuff which can be opened at the long side for introducing the nerve. It is fully implantable and atraumatic. The evoked potentials are sensed by standard thyroid electrodes. Real-time signal analysis and audio feedback are achieved by specially designed software. Homogeneous and stable signals were recorded throughout the operations. Thus real-time computer-based signal analysis was possible. Evoked potentials reached 300-900 mV. Mean time to place the cuff electrode was 5.5 min. The nerve was stimulated a mean of 63 min (range 55-99 min). No RLN lesions were detected postoperatively. The new vagal electrode was easy to handle and led to stable and reproducible signals. The stimulation current could be kept extremely low due to the special geometry of the electrode. It offers the possibility for uninterrupted, continuous laryngeal nerve monitoring in thyroid surgery. In an ongoing clinical trial its compatibility as an add-on for existing nerve monitoring devices is being tested.
Elastic low density aerogels derived from bis[3-(triethoxysilyl)propyl]disulfide, tetramethylorthosilicate and vinyltrimethoxysilane via a two-step process (2009)

A series of low density, porous structures were prepared using bis[3-(triethoxysilyl)propyl]disulfide (BTSPD), tetramethylorthosilicate (TMOS) and vinyltrimethoxysilane (VTMS) as precursors via a two-step (acid–base) sol-gel process followed by supercritical CO2 extraction. Using statistical experimental design methodology and empirical modelling, the concentrations of BTSPD, TMOS and VTMS were varied in the production of the monoliths and found to have a significant effect on their bulk density, porosity, BET surface areas, hydrophobicity and mechanical properties. Increasing the TMOS concentration significantly increases the surface area and Young's modulus while higher VTMS concentration improves hydrophobicity and higher BTSPD concentration leads to increased elastic recovery after compression. Optimized aerogels produced in the study have a combination of high Young's modulus, good hydrophobicity and near complete recovery after compression in agreement with model predictions.
Localizing on-scalp MEG sensors using an array of magnetic dipole coils (2018)

Accurate estimation of the neural activity underlying magnetoencephalography (MEG) signals requires co-registration i.e., determination of the position and orientation of the sensors with respect to the head. In modern MEG systems, an array of hundreds of low-Tc SQUID sensors is used to localize a set of small, magnetic dipole-like (head-position indicator, HPI) coils that are attached to the subject's head. With accurate prior knowledge of the positions and orientations of the sensors with respect to one another, the HPI coils can be localized with high precision, and thereby the positions of the sensors in relation to the head. With advances in magnetic field sensing technologies, e.g., high-Tc SQUIDs and optically pumped magnetometers (OPM), that require less extreme operating temperatures than low-Tc SQUID sensors, on-scalp MEG is on the horizon. To utilize the full potential of on-scalp MEG, flexible sensor arrays are preferable. Conventional co-registration is impractical for such systems as the relative positions and orientations of the sensors to each other are subject-specific and hence not known a priori. Herein, we present a method for co-registration of on-scalp MEG sensors. We propose to invert the conventional co-registration approach and localize the sensors relative to an array of HPI coils on the subject's head. We show that given accurate prior knowledge of the positions of the HPI coils with respect to one another, the sensors can be localized with high precision. We simulated our method with realistic parameters and layouts for sensor and coil arrays. Results indicate co-registration is possible with sub-millimeter accuracy, but the performance strongly depends upon a number of factors. Accurate calibration of the coils and precise determination of the positions and orientations of the coils with respect to one another are crucial. Finally, we propose methods to tackle practical challenges to further improve the method.
A Novel High-Power-Factor Single-Switch Electronic Ballast (2010)

A novel single-stage single-switch electronic ballast topology with a unity power factor is presented in this paper. The proposed circuit consists of an integrated buck-boost stage that operates in the discontinuous conduction mode to provide a high power factor and a single-switch current-fed resonant inverter to stabilize the lamp current. The proposed topology presents a low cost and compact electronic ballast design method. The detailed descriptions of the circuit's operating principles are provided in this paper. The design equations and mathematical analysis regarding the proposed circuit are discussed in this paper. The proposed ballast has been tested with an 18-W compact fluorescent lamp, and the experimental results confirmed that a very high power factor of 0.995 and an efficiency of 83.4% have been achieved.
Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia (2010)

Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been implicated, the molecular mechanism underlying this selectivity is unclear. In other cell types, the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway regulates the oxidative stress response. We found elevated Nrf2 signaling in untreated CLL cells compared with normal lymphocytes. Therefore, we tested 27 known electrophilic and antioxidant compounds with drug-like properties and determined their CLL-selective cytotoxicity and effect on Nrf2 signaling. The selected compounds were from five distinct structural classes; alpha-beta unsaturated carbonyls, isothiocyanates, sulfhydryl reactive metals, flavones, and polyphenols. Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1. alpha-beta Unsaturated carbonyl-containing compounds were selectively cytotoxic to CLL, and loss of the alpha-beta unsaturation abrogated Nrf2 activity and CLL toxicity. The alpha-beta unsaturated carbonyl containing compounds ethacrynic acid and parthenolide activated Nrf2 in normal peripheral blood mononuclear cells, but had a less potent effect in CLL cells. Furthermore, ethacrynic acid bound directly to the Nrf2-negative regulator Kelch-like ECH-associated protein 1 (Keap1) in CLL cells. These experiments document the presence of Nrf2 signaling in human CLL and suggest that altered Nrf2 responses may contribute to the observed selective cytotoxicity of electrophilic compounds in this disease.