gebhart/patrepeval huggingface dataset:
Quantification of Blood Flow in Brain Tumors: Comparison of Arterial Spin Labeling and Dynamic Susceptibility-weighted Contrast-enhanced MR Imaging (2003)

Arterial spin labeling is a suitable method for assessment of microvascular perfusion and allows distinction between high- and low-grade gliomas.
Solubilization of polycyclic aromatic hydrocarbons in micellar nonionic surfactant solutions (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubilization of polycyclic aromatic hydrocarbons in micellar nonionic surfactant solutionsDavid A. Edwards, Richard G. Luthy, and Zhongbao LiuCite this: Environ. Sci. Technol. 1991, 25, 1, 127–133Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/es00013a014https://doi.org/10.1021/es00013a014research-articleACS PublicationsRequest reuse permissionsArticle Views2840Altmetric-Citations607LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of Complexes Formed between TSG-6 andInter-α-inhibitor That Act as Intermediates in the Covalent Transfer ofHeavy Chains ontoHyaluronan (2005)

The high molecular mass glycosaminoglycan hyaluronan (HA) can become modified by the covalent attachment of heavy chains (HCs) derived from the serum protein inter-alpha-inhibitor (IalphaI), which is composed of three subunits (HC1, HC2 and bikunin) linked together via a chondroitin sulfate moiety. The formation of HC.HA is likely to play an important role in the stabilization of HA-rich extracellular matrices in the context of inflammatory disease (e.g. arthritis) and ovulation. Here, we have characterized the complexes formed in vitro between purified human IalphaI and recombinant human TSG-6 (an inflammation-associated protein implicated previously in this process) and show that these complexes (i.e. TSG-6 x HC1 and TSG-6 x HC2) act as intermediates in the formation of HC x HA. This is likely to involve two transesterification reactions in which an ester bond linking an HC to chondroitin sulfate in intact IalphaI is transferred first onto TSG-6 and then onto HA. The formation of TSG-6 x HC1 and TSG-6 x C2 complexes was accompanied by the production of bikunin x HC2 and bikunin x HC1 by-products, respectively, which were observed to break down, releasing free bikunin and HCs. Both TSG-6 x HC formation and the subsequent HC transfer are metal ion-dependent processes; these reactions have a requirement for either Mg2+ or Mn2+ and are inhibited by Co2+. TSG-6, which is released upon the transfer of HCs from TSG-6 onto HA, was shown to combine with IalphaI to form new TSG-6 x HC complexes and thus be recycled. The finding that TSG-6 acts as cofactor and catalyst in the production of HC x HA complexes has important implications for our understanding of inflammatory and inflammation-like processes.
Lateral cervical nucleus in the cat: functional organization and characteristics (1978)

1. The lateral cervical nucleus (LCN) was investigated with extracellular recordings in the anesthetized cat. A total of 556 LCN units were characterized; the locations of most of these were histologically verified. Half of these had receptive fields on the rostral third of the ipsilateral body surface including the face; 14% had fields on the thorax or abdomen, 33% had fields on the hindlimb or tail, and about 3% had receptive fields larger than one limb. 2. The LCN was observed to be somatotopically organized in experiments using angled microelectrode penetrations. Hindlimb units were dorsolateral, forelimb units ventromedial, and face units most medial within the LCN. In regions where LCN cells were present only in the medial portion of the dorsolateral funiculus, they were all forelimb units. 3. A special subpopulation (17%) of cells were clustered most ventromedially in the LCN. These units had large or disjoint receptive fields, and/or responded to deep, visceral, or noxious stimulation. A third of these did not project in the medial lemniscus (ML); many were synaptically activated by stimulation of the ML. Those that did project in the ML had significantly longer latencies than all other LCN units. It is suggested that this subpopulation contains local LCN interneurons. 4. The specific mechanoreceptor inputs were identified for each of 121 projecting LCN units. Receptor inputs were uniform across each receptive field; that is, each unit that responded to a given receptor type was observed to respond to receptors of that type throughout its receptive field. Input from large-fiber-diameter, velocity-sensitive mechanoreceptors was predominant. The absence of input from slowly adapting type I and II receptors and from joint receptors was confirmed. A significant number of units (17.3%) could be driven by only one receptor type. The LCN sample profile agrees closely with the receptor representation in the hindlimb portion of the spinocervical tract. It is concluded that these data that anatomic specification of convergence occurs in the LCN with respect to receptor connectivity, and that this specification originates in lamina IV of the dorsal horn. 5. Stimulation of the dorsal column nuclei synaptically excited 23% of the LCN units tested. In two cases it was possible to demonstrate, by collision, that this occurred via collaterals of spinocervical tract axons. It is concluded that some spinocervical axons have collaterals terminating in the rostral parts of the dorsal column nuclei.
A new model-based speech analysis/Synthesis system (2005)

A new model-based speech analysis/synthesis system is presented in this paper. In this model, the short-time spectrum of speech is modeled as the product of an excitation spectrum and a spectral envelope. The spectral envelope is some smoothed version of the speech spectrum and the excitation spectrum is represented by the pitch period and a voiced/unvoiced (V/UV) decision for each harmonic. In speech analysis, the model parameters are estimated by explicit comparison between the original speech spectrum and the synthetic speech spectrum. Preliminary results indicate that speech and noisy speech synthesized based on this model do not have the "buzziness" typically associated with vocoder speech and is essentially the same as the original speech or the noisy speech in both intelligibility and quality. Potential applications of this new model and its parameter estimation include high quality speech analysis/synthesis, time scale modification of speech and noisy speech, and pitch detection.
Heparan Sulfate Acts as a Bone Morphogenetic Protein Coreceptor by Facilitating Ligand-induced Receptor Hetero-oligomerization (2010)

Cell surface heparan sulfate (HS) not only binds several major classes of growth factors but also sometimes potentiates their activities--an effect usually termed "coreception." A view that coreception is due to the stabilization of growth factor-receptor interactions has emerged primarily from studies of the fibroblast growth factors (FGFs). Recent in vivo studies have strongly suggested that HS also plays an important role in regulating signaling by the bone morphogenetic proteins (BMPs). Here, we provide evidence that the mechanism of coreception for BMPs is markedly different from that established for FGFs. First, we demonstrate a direct, stimulatory role for cell surface HS in the immediate signaling activities of BMP2 and BMP4, and we provide evidence that HS-BMP interactions are required for this effect. Next, using several independent assays of ligand binding and receptor assembly, including coimmunoprecipitation, cross-linking, and fluorescence fluctuation microscopy, we show that HS does not affect BMP binding to type I receptor subunits but instead enhances the subsequent recruitment of type II receptor subunits to BMP-type I receptor complexes. This suggests a view of HS as a catalyst of the formation of signaling complexes, rather than as a stabilizer of growth factor binding.
A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer. (1999)

Micromolar concentrations of tamoxifen inhibit the activity of protein kinase C and were recently shown to inhibit prostate cancer cell growth in preclinical studies. Because micromolar concentrations can be attained with high-dose therapy, the clinical activity of high-dose tamoxifen was evaluated in patients with metastatic adenocarcinoma of the prostate. Between December 1993 and February 1997, 30 patients with hormone-refractory metastatic adenocarcinoma of the prostate were continuously administered tamoxifen at 160 mg/m2/day. Therapy was continued until disease progression. All study patients had failed prior treatment with combined androgen blockade, had castrate levels of testosterone, and were heavily pretreated, having received a median of three prior regimens. The average steady-state plasma concentration of tamoxifen was 2.96+/-1.32 microM (mean +/- SD). Grade 3 neurotoxicity was observed in 29% of patients and was rapidly reversible and readily managed with dose modification. Otherwise, grade 3 toxicities were rare. One partial response (80% decline in prostate-specific antigen) was observed (3.3%), whereas disease stabilization was observed in six patients (20%), for a combined partial response/stable disease response rate of 23%. Median time to progression was 2.1 months, and median survival time was 10.5 months. High-dose tamoxifen therapy was well tolerated and associated with micromolar concentrations of tamoxifen in human plasma, and it demonstrated activity, albeit limited, in a heavily pretreated patient cohort with hormone-refractory prostate cancer. These findings suggest that further investigation of the role of protein kinase C modulation in prostate cancer is warranted.
Compression systems for hearing aids and cochlear prostheses. (1986)

Audio and speech compression systems have suffered several characteristic deficiencies. Single-channel compression systems cannot compress wideband signals without suffering from either spectral distortion or the inability to respond quickly to fast transients. When the input signal contains noise in addition to the desired speech signal, single-channel systems unnecessarily attenuate speech information. Single-channel compressors cannot compress the input signal differentially as a function of frequency. Multichannel compressors are capable of different levels of compression as a function of frequency. However, standard multichannel compressors unnecessarily attenuate important information about the shape of the short-term speech spectrum. This has resulted in poorer speech perception when using standard multichannel systems as compared with single-channel compression systems. A more general form of multichannel compression can emphasize information about the shape of the short-term speech spectrum. Susceptibility to many forms of noise is also reduced with such multichannel systems. Spectral distortion and undesired rapid overshoots and undershoots of signal level, characteristic of many single- and multi-channel systems, can be substantially reduced with such systems.
Role of Thoracic Radiotherapy Combined with Chemotherapy in Limited Stage Small Cell Lung Cancer (SCLC) (1990)

We initiated a prospective randomized multicenter trial to clarify the role of radiotherapy in the treatment of the primary tumor in small cell lung cancer stage limited disease. Patients were randomized to receive only chemotherapy (n = 27), or chemotherapy and radiotherapy of 30 Gy (n = 34) or chemotherapy and radiotherapy of 50 Gy (n = 30). Radiotherapy was administered after the third chemotherapy cycle. All patients received prophylactic total-brain irradiation of 30 Gy. The chemotherapy consisted of 6 cycles of adriamycin, cyclophosphamide and vincristin (ACO). 415 patients entered the trial. According to eligibility criteria 97 patients were randomized and 91 patients were evaluable for response. The total response rate (CR and PR) was 69% not being statistically different between all groups. No differences in survival time were observed between patients receiving 30 Gy (median = 13.5 months) and those receiving 50 Gy (median = 12.4 months). However patients treated with radiotherapy and chemotherapy showed a statistically significant improvement of survival time compared to patients receiving chemotherapy alone (median = 9.7 months).
Preparation of cyclic 2′,3′‐monophosphates of oligoadenylates (A2′p)nA > p and A3′p(A2′p)n‐1A>p (1994)

The action of the guanylyl-preferring RNase from Bacillus intermedius (binase) on a mixture of oligoadenylates with randomly distributed 2'-5' and 3'-5' internucleotide bonds [(A2'/3'p)n] under conditions sufficient for complete hydrolysis of poly(A) results in a mixture containing a single circular oligoadenylate and two series of linear oligoadenylates ending in cyclic 2',3'-phosphate. Individual compounds formed upon digestion of (A2'/3'p)n with binase have been isolated. Their structure was determined on the basis of their chemical and enzymatic conversions and confirmed by 1H-, 13C- and 31P-NMR spectra. According to these data, the circular triadenylate contains one 2'-5' and two 3'-5' internucleotide bonds, linear oligoadenylates of one series contain exclusively 2'-5' internucleotide bonds [(A2'p)nA > p], while each compound of the other series contains a single 3'-5' internucleotide bond connecting the 5'-ultimate nucleotide residue with the penultimate one [A3'p(A2'p)n-1A > p]. The incubation of compounds of the former series A3' p(A2'p)n > p at pH 1.0 and the subsequent action of phosphatase results in successive formation of compounds of two other new series: A3'p(A2'p)nA2'(3')p and A3'p(A2'p)nA.
Two‐way cleavage of β‐amyloid protein precursor by multicatalytic proteinase (1992)

The beta-amyloid protein (beta-AP) derived from a beta-amyloid protein precursor (APP) is a hallmark of Alzheimer's disease. The abundant generation of beta-AP suggests the abnormal processing of APP, but the molecular mechanism remains unclear. The main APP-processing enzyme was purified from the rat brain and identified to be a macropain-like multicatalytic proteinase. The purified enzyme cleaved the Gln15-Lys16 bond of beta-AP, but altered to cleave at the N-terminus of beta-AP to release the extracellular domain of beta-AP in the presence of Ca2+. These findings suggest that the functional change in this multicatalytic proteinase may result in abnormal processing of APP.
Neural agrin controls maturation of the excitation-contraction coupling mechanism in human myotubes developing in vitro (2007)

The aim of this study was to elucidate the mechanisms responsible for the effects of innervation on the maturation of excitation-contraction coupling apparatus in human skeletal muscle. For this purpose, we compared the establishment of the excitation-contraction coupling mechanism in myotubes differentiated in four different experimental paradigms: 1) aneurally cultured, 2) cocultured with fetal rat spinal cord explants, 3) aneurally cultured in medium conditioned by cocultures, and 4) aneurally cultured in medium supplemented with purified recombinant chick neural agrin. Ca(2+) imaging indicated that coculturing human muscle cells with rat spinal cord explants increased the fraction of cells showing a functional excitation-contraction coupling mechanism. The effect of spinal cord explants was mimicked by treatment with medium conditioned by cocultures or by addition of 1 nM of recombinant neural agrin to the medium. The treatment with neural agrin increased the number of human muscle cells in which functional ryanodine receptors (RyRs) and dihydropyridine-sensitive L-type Ca(2+) channels were detectable. Our data are consistent with the hypothesis that agrin, released from neurons, controls the maturation of the excitation-contraction coupling mechanism and that this effect is due to modulation of both RyRs and L-type Ca(2+) channels. Thus, a novel role for neural agrin in skeletal muscle maturation is proposed.
SPECTRAL PROPERTIES OF DIRAC SYSTEMS WITH COEFFICIENTS INFINITE AT INFINITY (Wave phenomena and asymptotic analysis) (2003)

It is well known that aone-dimensional Schr\"odinger operator $-\frac{d^{2}}{dx^{2}}+q(x)$ with potential $q$ satisfying $\lim_{-\cdot 1_{--}}q(x)=\infty$ has apurely discrete spectrum.If, on the other hand, $\lim q(x)=-\infty$, the situation is entirely different.By aclassical result, $xarrow\infty$ obtained independently by Hartman [6] and Shnol' [17], the spectrum is then purely absolutely continuous, filling the whole real line, if $|q(x)|=o(x^{2})(xarrow\infty)$ .In the limiting case $|q(x)|=O(x^{2})(xarrow\infty)$ this is no longer true, as shown by Halvorsen [5] in a counterexample for which the essential spectrum has gaps.For potentials tending $\mathrm{t}\mathrm{o}-\infty$ faster than $O(x^{2})$ , the singular end-point $\infty$ , in the limit-point case in the above situations, changes its behaviour to an (oscillatory) limit-circle case, giving rise to a
The Middeck Active Control Experiment (MACE): using space for technology research and development (2005)

The Middeck Active Control Experiment (MACE) is a United States Space Shuttle flight experiment which flew on STS-67 in March of 1995. MACE was designed by the Space Engineering Research Center at the Massachusetts Institute of Technology, in collaboration with Payload Systems Incorporated, the NASA Langley Research Center, and Lockheed Missiles and Space Company. The goal is to explore approaches to achieving high precision pointing and vibration control of future spacecraft and satellites. In particular, MACE extends the bandwidth of conventional rigid body instrument pointing and attitude controllers to include the flexible modes of the satellite. Since the success of such control is intimately dependent upon the accuracy of the spacecraft model used for control design, MACE is essentially a spacecraft modeling validation effort where success is determined by the control performance and predictability that is achieved in Earth orbit. MACE builds upon the concept of the Middeck O-Gravity Dynamics Experiments (MODE), which flew on STS-40, STS-48 and STS-62 as a dynamics test facility to characterize fluid, Space Station structure, and crew motion dynamics in zero-gravity. MACE augments the MODE facility with real-time digital control capabilities.
Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel (1989)

In an attempt to repair articular cartilage, allograft articular chondrocytes embedded in collagen gel, were transplanted into full-thickness defects in rabbit articular cartilage. Twenty-four weeks after the transplantation, the defects were filled with hyaline cartilage, specifically synthesising Type II collagen. These chondrocytes were autoradiographically proven to have originated from the transplanted grafts. Assessed histologically the success rate was about 80%, a marked improvement over the results reported in previous studies on chondrocyte transplantation without collagen gel. By contrast, the defects without chondrocyte transplantation healed with fibrocartilage. Immunological enhancement induced by transplanted allogenic chondrocytes or collagen was not significant at eight weeks after treatment, so far as shown by both direct and indirect blastformation reactions. Thus, allogenic transplantation of isolated chondrocytes embedded in collagen gel appears to be one of the most promising methods for the restoration of articular cartilage.
Photobiomodulation accelerates orthodontic alignment in the early phase of treatment (2013)

Photobiomodulation produced clinically significant changes in the rates of tooth movement as compared to the control group during the alignment phase of orthodontic treatment.
An Internal Control for Routine Diagnostic PCR: Design, Properties, and Effect on Clinical Performance (1998)

We constructed internal controls (ICs) to provide assurance that clinical specimens are successfully amplified and detected. The IC nucleic acids contain primer binding regions identical to those of the target sequence and contain a unique probe binding region that differentiates the IC from amplified target nucleic acid. Because only 20 copies of the IC are introduced into each test sample, a positive IC signal indicates that amplification was sufficient to generate a positive signal from targets present at the limit of test sensitivity. The COBAS AMPLICOR Chlamydia trachomatis, Neisseria gonorrhoeae, Mycobacterium tuberculosis, and human hepatitis C virus tests exhibited inhibition rates ranging from 5 to 9%. Approximately 64% of these inhibitory specimens were not inhibitory when a second aliquot was tested. Because repeatedly inhibitory specimens were not reported as false negative and because additional infected specimens were detected during retesting, test sensitivities were 1 to 6% greater than they would have been if the IC had not been used.
Electrical Inhibition of Pain by Stimulation of the Dorsal Columns (1967)

SHEALY, C. NORMAN M.D.; MORTIMER, J. THOMAS M.S.; RESWICK, JAMES B. D.Sc. Author Information
Hardware oriented content-adaptive fast algorithm for variable block-size integer motion estimation in H.264 (2005)

Motion estimation can reduce temporal redundancy and achieve high compression capability in video coding standards. In H.264, the coding gain is further improved by variable block-size motion estimation (VBSME). In order to reduce the complexity, many fast algorithms have been proposed. Though previous works can reduce a large amount of computation, most of them are not suitable for hardware implementation and not robust for complex motion videos. A content-adaptive fast algorithm for variable block-size integer motion estimation (VBSIME) is proposed in this paper. Motion activity is exploited to improve the coding efficiency. Because of the good data reuse scheme and simple control flow, the proposed algorithm is applicable to hardware implementation. According to the simulation results, about 98% searching candidates and 86% encoding time are reduced with at most 0.05 dB quality drop in average compared with full search even for complex motion videos.