gebhart/patrepeval huggingface dataset:
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: International Multidisciplinary Classification of Lung Adenocarcinoma: Executive Summary (2011)

This classification is intended to support clinical practice as well as research investigation and clinical trials.
Verifying clock schedules (1992)

Many recent papers have formulated both timing verification and optimization as mathematical programming problems. Such formulations correctly handle level-sensitive latches, long and short path considerations, and sophisticated multi-phase clocking schemes.
Tectonic stress and the spectra of seismic shear waves from earthquakes (1970)

An earthquake model is derived by considering the effective stress available to accelerate the sides of the fault. The model describes near- and far-field displacement-time functions and spectra and includes the effect of fractional stress drop. It successfully explains the near- and far-field spectra observed for earthquakes and indicates that effective stresses are of the order of 100 bars. For this stress, the estimated upper limit of near-fault particle velocity is 100 cm/sec, and the estimated upper limit for accelerations is approximately 2g at 10 Hz and proportionally lower for lower frequencies. The near field displacement u is approximately given by u(t) = (σ/μ) βr(1 - e−t/r) where. σ is the effective stress, μ is the rigidity, β is the shear wave velocity, and τ is of the order of the dimension of the fault divided by the shear-wave velocity. The corresponding spectrum is

Ω(ω)=σβμ1ω(ω2+τ−2)1/2(1)

The rms average far-field spectrum is given by

〈 Ω(ω) 〉=〈 Rθϕ 〉σβμrRF(e)1ω2+α2(2)

where 〈Rθϕ〉 is the rms average of the radiation pattern; r is the radius of an equivalent circular dislocation surface; R is the distance; F(e) = {[2 – 2e][1 – cos (1.21 eω/α)] +e2}1/2; e is the fraction of stress drop; and α = 2.21 β/r. The rms spectrum falls off as (ω/α)−2 at very high frequencies. For values of ω/α between 1 and 10 the rms spectrum falls off as (ω/α)−1 for e < ∼0.1. At low frequencies the spectrum reduces to the spectrum for a double-couple point source of appropriate moment. Effective stress, stress drop and source dimensions may be estimated by comparing observed seismic spectra with the theoretical spectra.
Measurement of peptidoglycan antibodies by a radioimmunoassay. (1975)

Staphylococcus epidermidis peptidoglycans solubilized by sonication or lysozyme digestion, and synthetic peptidoglycan analogs such as HSA-carboxymethyl-Gly-L-Ala-L-Ala-D-Ala-D-Ala (HSA-pentapeptide) or L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala (pentapeptide) have been labeled with 125I and tested for their applicability in the radioactive antigen binding assay. Use of radioiodinated Staph. epidermidis peptidoglycans was found to be considerably impeded by the presence of at least 2 different antigenic sites on such molecules, the pentapeptide and the glycan determinant. Application of labeled HSA-pentapeptide was limited by the necessity to use PEG for precipitation of Ag-Ab-complexes and by short linear potions of binding curves. However, the synthetic pentapeptide hapten, radioiodinated by the active ester method of BOLTON and HUNTER, proved to be a most useful regent for the selective measurement of pentapeptide antibody. Inhibition studies indicated that the immunological specificity of the labeled hapten was retained. Pentapeptide binding curves were linear from 15-500 g/ml of antibody. Generally, there was good agreement between pentapeptide antibody concentrations measured by radioimmunoassay and quantitative precipitation.
Alternative Polymer Systems for Proton Exchange Membranes (PEMs) (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlternative Polymer Systems for Proton Exchange Membranes (PEMs)Michael A. Hickner, Hossein Ghassemi, Yu Seung Kim, Brian R. Einsla, and James E. McGrathView Author Information Sandia National Laboratory, Albuquerque, New Mexico 87185, Department of Chemical Engineering, Case Western Reserve University, Cleveland, Ohio, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, and Department of Chemistry, Macromolecules and Interfaces Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 Cite this: Chem. Rev. 2004, 104, 10, 4587–4612Publication Date (Web):October 13, 2004Publication History Received27 February 2004Published online13 October 2004Published inissue 1 October 2004https://pubs.acs.org/doi/10.1021/cr020711ahttps://doi.org/10.1021/cr020711aresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views19430Altmetric-Citations2548LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Materials,Membranes,Polymers,Thin films Get e-Alerts
Preparation and characterization of polyurethane/soluble eggshell membrane nanofibers (2014)

Superfine Particles (SP) of soluble eggshell membrane and medical grade polyurethane (MPU) blend nanofibers were prepared by electrospinning different blend ratios of SP/MPU suspensions for regeneration of the natural fiber-like structure of the eggshell membrane. The addition of SP had no obvious effect on the electrospinning process of MPU nanofibers, and the SP were randomly dispersed in the MPU nanofibers with no agglomeration of SP when the amount of SP was less than 20 wt%. Although the average diameter of the blend nanofibers is approximately 30% larger than that of the pure MPU nanofibers, they exhibit excellent tensile strength and tensile resilience that are close to those for pure MPU nanofibers. In addition, the blend nanofibers become fully hydrophilic, and the water contact angle of the blend nanofibers decreases dramatically to 0°. Therefore, with the advantages of a collagen ingredient and good hydrophilicity, these blend nanofibers are suitable for applications such as facial masks, wound dressings, and pharmaceutical carrier materials.
Role of sugar chains in the expression of the biological activity of human erythropoietin. (1992)

Various deglycosylated derivatives of recombinant human erythropoietin (hEPO) were prepared and used to determine the role of the sugar chains in the expression of its biological activity in vivo and in vitro. Three N-linked oligosaccharides of hEPO have been partially or fully removed to obtain N-glycan (NG) (2)-, NG(1)-, and NG(0)-hEPO carrying two, one, and no N-linked sugar chains, respectively. The preparation lacking only O-linked sugar chain O O-glycan (OG) (0)-hEPO was also used. As de-N-glycosylation proceeded, the in vivo activity of the hormone decreased drastically, and the activity of these derivatives was correlated with the number of sialic acids bound to them. On the contrary, the in vitro activity was increased by the de-N-glycosylation; NG(0)-hEPO showed a 3-fold higher specific activity than the intact hormone. This was confirmed by binding experiments of the derivatives to target cells. The in vitro activity and the affinity also correlated with the number of sialic acids bound to the deglycosylated hEPO preparations. On the other hand, OG(0)-hEPO was as active as the intact hormone in vivo and in vitro. In conclusion, the N-linked sugar chains are not required for in vitro activity but required for in vivo activity, acting as anchors for the essential terminal sialic acids. The O-linked sugar chain has no essential role in the biological activity of the hormone in vivo or in vitro.
Hydrogen generation by hydrolysis of sodium tetrahydroborate: effects of acids and transition metals and their salts (1985)

A study was undertaken in order to investigate the potential of NaBH4 as a precursor fuel source for a hydrogen–oxygen (air) fuel cell. At appropriate initial acid concentration, hydrolysis of NaBH4 is nearly 80% complete in 2.5 min, and nearly 90% complete in 10 min at 21.7 °C. Transition metals and their salts also accelerate hydrolysis of NaBH4. The effect of transition metals is characterized by zero-order kinetics.
High-level syntax for H.26L: first results (2000)

This paper introduces some preliminary results of the standardization process of ITU-T's H26L project. This forthcoming video coding standard will not only significantly improve the coding efficiency, but it will also introduce new concepts such as network friendliness, which are not common in current video coding approaches. The paper focuses on the high level syntax which resides hierarchically above the macroblock layer. Data partitioning techniques are used to separate data of different types from each other. The partitions are arranged in packets of data with different importance for the reproduced picture quality. Along with unequal error protection, which can either be a function of the underlying network or implemented on the application layer, the error resilience and thus the reproduced picture quality in error prone environments is greatly improved. To verify the findings, simulation results for an Internet/RTP environment, based on real-world observations of the current Internet that do not assume network-based quality of service, are included.
Comparison of chlorambucil and prednisone versus cyclophosphamide, vincristine, and prednisone as initial treatment for chronic lymphocytic leukemia: long-term follow-up of an Eastern Cooperative Oncology Group randomized clinical trial. (1991)

The Eastern Cooperative Oncology Group (ECOG) conducted a study in which patients with advanced chronic lymphocytic leukemia (CLL) were randomized between a regimen consisting of chlorambucil (30 mg/m2 orally day 1) and prednisone (80 mg orally days 1 to 5) (C + P) administered every 2 weeks and a more intensive regimen of cyclosphosphamide (300 mg/m2 orally days 1 to 5), vincristine (1.4 mg/m2 intravenously [IV] day 1), and prednisone (100 mg/m2 orally days 1 to 5) (CVP) given every 3 weeks. Treatment was continued for up to 18 months to maximal response. Of the 122 eligible patients, 60 received C + P, while 62 received CVP. With a median follow-up of 7 years, there were no significant differences in survival (4.8 v 3.9 years, P = .12), complete remission (CR) rate (25% v 23%; P = .83), or duration of response (2.0 v 1.9 years; P = .78) between C + P and CVP. Toxicity was modest despite the prolonged treatment. The long median survival of 4.1 years for stage III and IV patients is superior to that usually reported. This could stem from continuing treatment to maximal response rather than an increase in intensity of therapy. These results are comparable to those reported with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy by other investigators. The data suggest that intermittent C + P administered to maximal response continues to be the standard treatment approach for advanced CLL.
A Cell‐Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA (2015)

Despite significant advances in foldamer chemistry, tailored delivery systems based on foldamer architectures, which provide a high level of control over secondary structure, are curiously rare among non-viral technologies for transporting nucleic acids into cells. A potent pH-responsive, bioreducible cell-penetrating foldamer (CPF) was developed through covalent dimerization of a short (8-mer) amphipathic oligourea sequence bearing histidine-type units. This CPF exhibits a high capacity to assemble with pDNA and mediates efficient delivery of nucleic acids into the cell. Furthermore, it does not adversely affect cellular viability and was shown to compare favorably with a cognate peptide transfection agent based on His-rich sequences.
Reduction of Azides to Primary Amines in Substrates Bearing Labile Ester Functionality. Synthesis of a PEG-Solubilized, “Y”-Shaped Iminodiacetic Acid Reagent for Preparation of Folate-Tethered Drugs1 (1999)

[formula: see text] Anhydride 3 is a useful reagent for the synthesis of triply linked drug conjugates. Examples using paclitaxel are provided. Conversion of the azido moiety to a primary amine in the presence of substrates bearing labile ester functionality requires the use of tin/mercaptan reducing system which includes methanol exchange equilibration to effect nitrogen-tin bond scission.
Incremental Reconstruction of Manifold Surface from Sparse Visual Mapping (2012)

Automatic image-based-modeling usually has two steps: Structure from Motion (SfM) and the estimation of a triangulated surface. The former provides camera poses and a sparse point cloud. The latter usually involves dense stereo. From the computational standpoint, it would be nice to avoid dense stereo and estimate the surface from the sparse cloud directly. Furthermore, it would be useful for online applications to update the surface while the camera is moving in the scene. This paper deals with both requirements: it introduces an incremental method which reconstructs a surface from a sparse cloud estimated by incremental SfM. The context is new and difficult since we ensure the resulting surface to be manifold at all times. The manifold property is important since it is needed by differential operators involved in surface refinements. We have experimented with a hand-held omni directional camera moving in a city.
An overview of the challenges and progress in meeting the E-911 requirement for location service (1998)

When the FCC created the rules for wireless Enhanced 911 (E-911) service, a flurry of research and development activities dedicated to locating the position of emergency callers followed. The current deadline for this capability is October 1, 2001. We review the unique challenges and some of the proposed approaches for each of the major wireless standards.
Expression of glucose transporters in head‐and‐neck tumors (1994)

The expression of glucose transporter genes (GLUTI-4) was studied in 20 head-and-neck tumors of 18 patients. All tumors--16 of which were squamous-cell carcinomas (SCC)--expressed GLUT1 and/or GLUT3 mRNA, while detectable levels of GLUT2 or GLUT4 mRNA were not observed. The signals for GLUT1 and GLUT3 mRNAs varied markedly throughout the SCC tumor population but no clear relationship with the grade of differentiation was found. The high GLUT expression observed in some tumors was not associated with amplification or rearrangement of the corresponding genes. Immunohistochemistry of 5 SCCs showed that GLUT1 protein was located in tumor-cell membranes in relation to the level of mRNA expression. We conclude that both GLUT1 and GLUT3 are involved in basal glucose uptake of extracranial head-and-neck tumors. The increased expression of these high-affinity GLUT isoforms may be related to the growth maintenance of cancer tissue in cases of limited supply of substrate e.g., in poorly vascularized tumor areas.
Phage display selection of ligand residues important for Src homology 3 domain binding specificity. (1995)

The Src homology 3 (SH3) domain is a 50-aa modular unit present in many cellular proteins involved in intracellular signal transduction. It functions to direct protein-protein interactions through the recognition of proline-rich motifs on associated proteins. SH3 domains are important regulatory elements that have been demonstrated to specify distinct regulatory pathways important for cell growth, migration, differentiation, and responses to the external milieu. By the use of synthetic peptides, ligands have been shown to consist of a minimum core sequence and to bind to SH3 domains in one of two pseudosymmetrical orientations, class I and class II. The class I sites have the consensus sequence ZP(L/P)PP psi P whereas the class II consensus is PP psi PPZ (where psi is a hydrophobic residue and Z is a SH3 domain-specific residue). We previously showed by M13 phage display that the Src, Fyn, Lyn, and phosphatidylinositol 3-kinase (PI3K) SH3 domains preferred the same class I-type core binding sequence, RPLPP psi P. These results failed to explain the specificity for cellular proteins displayed by SH3 domains in cells. In the current study, class I and class II core ligand sequences were displayed on the surface of bacteriophage M13 with five random residues placed either N- or C-terminal of core ligand residues. These libraries were screened for binding to the Src, Fyn, Lyn, Yes, and PI3K SH3 domains. By this approach, additional ligand residue preferences were identified that can increase the affinity of SH3 peptide ligands at least 20-fold compared with core peptides. The amino acids selected in the flanking sequences were similar for Src, Fyn, and Yes SH3 domains; however, Lyn and PI3K SH3 domains showed distinct binding specificities. These results indicate that residues that flank the core binding sequences shared by many SH3 domains are important determinants of SH3 binding affinity and selectivity.
Genetic feature subset selection for gender classification: a comparison study (2003)

We consider the problem of gender classification from frontal facial images using genetic feature subset selection. We argue that feature selection is an important issue in gender classification and demonstrate that Genetic Algorithms (GA) can select good subsets of features (i.e., features that encode mostly gender information), reducing the classification error. First, Principal Component Analysis (PCA) is used to represent each image as a feature vector (i.e., eigen-features) in a low-dimensional space. Genetic Algorithms (GAs) are then employed to select a subset of features from the low-dimensional representation by disregarding certain eigenvectors that do not seem to encode important gender information. Four different classifiers were compared in this study using genetic feature subset selection: a Bayes classifier, a Neural Network (NN) classifier, a Support Vector Machine (SVM) classifier, and a classifier based on Linear Discriminant Analysis (LDA). Our experimental results show a significant error rate reduction in all cases. The best performance was obtained using the SVM classifier. Using only 8.4% of the features in the complete set, the SVM classifier achieved an error rate of 4.7% from an average error rate of 8.9% using manually selected features.
High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System (2007)

The development of a contrast agent for a laser optoacoustic imaging system (LOIS) can significantly widen preclinical and clinical applications of this imaging modality for early detection of cancerous tumors. Gold nanorods were engineered to enhance the contrast for optoacoustic imaging. Under in vivo conditions, 25 microL of gold nanorods solution at a concentration of 1.25 pM were injected into nude mice and detected using a single-channel acoustic transducer. LOIS was used to visualize the distribution of gold nanoparticles at a concentration of 125 pM in vivo when 100 microL of solution of gold nanoparticles was delivered subcutaneously. Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging.
Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome. The Nebraska Lymphoma Study Group (1990)

We describe the chromosomal abnormalities found in 104 previously untreated patients with non-Hodgkin's lymphoma (NHL) and the correlations of these abnormalities with disease characteristics. The cytogenetic method used was a 24- to 48-hour culture, followed by G-banding. Several significant associations were discovered. A trisomy 3 was correlated with high-grade NHL. In the patients with an immunoblastic NHL, an abnormal chromosome no. 3 or 6 was found significantly more frequently. As previously described, a t(14;18) was significantly correlated with a follicular growth pattern. Abnormalities on chromosome no. 17 were correlated with a diffuse histology and a shorter survival. A shorter survival was also correlated with a +5, +6, +18, all abnormalities on chromosome no. 5, or involvement of breakpoint 14q11-12. In a multivariate analysis, these chromosomal abnormalities appeared to be independent prognostic factors and correlated with survival more strongly than any traditional prognostic variable. Patients with a t(11;14)(q13;q32) had an elevated lactate dehydrogenase (LDH). Skin infiltration was correlated with abnormalities on 2p. Abnormalities involving breakpoints 6q11-16 were correlated with B symptoms. Patients with abnormalities involving breakpoints 3q21-25 and 13q21-24 had more frequent bulky disease. The correlations of certain clinical findings with specific chromosomal abnormalities might help unveil the pathogenetic mechanisms of NHL and tailor treatment regimens.
Administration of Testosterone Undecanoate in Postmenopausal Women (2000)

Testosterone undecanoate displayed a rapid absorption and turnover and may offer an alternative for androgen treatment in women. Expanded pharmacokinetic studies in larger and more homogeneous groups of postmenopausal women should be performed. The individual variations were considerable, and regular monitoring of testosterone serum levels to avoid overtreatment is recommended.
Biologic properties of a Ch2 domain‐deleted recombinant immunoglobulin (1993)

Monoclonal antibody (MAb) B72.3 reacts with TAG-72, a high-molecular-weight mucin expressed on several types of human carcinoma, and is currently being used in clinical trials for the diagnosis and therapy of human carcinoma. An expression construct containing cDNA encoding an immunoglobulin (Ig) heavy chain, with the variable region of murine MAb B72.3 and a human Ig constant region with a deletion of the CH2 domain, was generated. Immunoglobulin from the transfectoma with the highest expression of the TAG-72 immunoreactive antibody was designated MAb chimeric (c) B72.3 delta CH2. The pharmacokinetics of serum clearance of iodine-labeled MAbs cB72.3 delta CH2 and the intact cB72.3 were compared in athymic mice. By 24 hr, less than 1% of the cB72.3 delta CH2 was left in the plasma, while 36% of the cB72.3 still remained. The T1/2 alpha values of the cB72.3 delta CH2 and cB72.3 MAbs were 1.7 and 2.4 hr, respectively. The T1/2 beta values were 7.8 hr for the domain-deleted cMAb and 48.9 hr for cB72.3. Biodistribution studies in athymic mice bearing LS-174T xenografts showed a reduction in the percentage of injected dose per gram in tumor with 131I-cB72.3 delta CH2; however, the 131I-cB72.3 delta CH2 both localized to tumors faster and cleared from the blood faster than the 125I-cB72.3 MAb. Only trace amounts of the 131I-cB72.3 delta CH2 were detected in normal tissues, including kidney. The faster clearance rate, more rapid tumor targeting and lack of metabolic uptake in normal tissues demonstrated with the iodine-labeled CH2 domain-deleted cMAb may be an advantage for certain clinical protocols.
Syndrome of Rochalimaea henselae Adenitis Suggesting Cat Scratch Disease (1993)

Rochalimaea henselae can be a cause of cat scratch disease in immunocompetent patients.