gebhart/patrepeval huggingface dataset:
An adaptation of the Cambridge Colour Test for use with animals (2006)

Recently, molecular biological techniques have presented new opportunities for addressing questions concerning the neural mechanisms involved in color coding, thereby rousing renewed interest in animal color vision testing. We have modified a computer-based assessment tool, the Cambridge Colour Test, to make it suitable for use with animals. Here, the validity and reliability of the testing method were evaluated using squirrel monkeys. Because the chromatic stimuli and the achromatic backgrounds of the test consist of dots that vary in lightness, the stimulus parameters can be adjusted so that animals are not able to use luminance differences to make correct discriminations. Thus, in contrast to methods used previously, this test does not require that time be spent equating the luminance of each chromatic stimulus examined. Furthermore, the computer video-display based design of the testing apparatus can be easily replicated and adapted for use with many species in a variety of settings. In the present experiments, the squirrel monkeys' behavioral results agreed with the predictions for their color vision based on genetic analysis and electroretinography (ERG) spectral sensitivity data. Repeated measurements were highly consistent. Thus, an adaptation of the Cambridge Colour Test provides a valid and reliable method for testing color vision in animals.
WCDMA for UMTS (2002)

From the Publisher:
WCDMA for UMTS provides a complete picture of the Wideband CDMA (Code Division Multiple Access) air interface of the 3rd generation cellular systems - UMTS (Universal Mobile Telecommunications Systems). WCDMA is designed for multimedia communications including high quality images and video, and access to services with high data rates. These capabilities will create new business opportunities for manufacturers, operators and for the providers of content and applications.
* Explains the key parts of the WCDMA standard and provides guidelines for its efficient use
* Presents network dimensioning and coverage and capacity planning of WCDMA
* Introduces radio resource management algorithms in the WCDMA network
* Examines the coverage and capacity of WCDMA up to 2Mbps using numerous simulation results
* Introduces the TDD (Time Divisions Duplex) mode
* Discusses the co-existence of TDD and FDD (Frequency Divisions Duplex) and highlights their main differences
Now includes the main modifications made to the 3GPP standard up until the end of 2000 and features the following new material:
* Reference terminal classes
* Current status of UMTS licensing
* Capacity upgrade paths and capacity per km2
* Inter-frequency handovers and inter-system handovers to GSM
* Antenna diversity gain measurements in the WCDMA experimental system
Written by leading experts in the field, this practical approach to the key features in WCDMA will have wide-ranging appeal to Research and Development Engineers, Practising Engineers, Cellular Operators, Technical Managers and Students on Telecommunications courses.
CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhil-15) is associated with robust expansion of peripheral blood CD56+ NK cells (2014)

Meeting abstracts IL-15 activates and induces the proliferation of CD8+ T cells and NK cells. The Cancer Immunotherapy Trials Network (CITN) is conducting a Phase I, open-label, dose-escalation study of subcutaneous (SQ) rhIL-15 in advanced melanoma, renal cell, non-small cell lung and squamous
Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS (2005)

Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).
Identifying Mutations in Duplicated Functions in Saccharomyces cerevisiae: Recessive Mutations in HMG-CoA Reductase Genes (1987)

The two yeast genes for 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, HMG1 and HMG2, each encode a functional isozyme. Although cells bearing null mutations in both genes are inviable, cells bearing a null mutation in either gene are viable. This paper describes a method of screening for recessive mutations in the HMG1 gene, the gene encoding the majority of HMG-CoA reductase activity in the cell. This method should be applicable to the isolation of mutations in other recovered in HMG1. These mutations exhibited intragenic complementation: one allele is in one complementation group and three alleles are in a second complementation group. Assays of HMG-CoA reductase activity indicated that the point mutations destroy most if not all of the activity encoded by HMG1. Intragenic complementation occurred with partial restoration of enzymatic activity. HMG1 was mapped to the left arm of chromosome XIII near SUP79, and HMG2 was mapped to the right arm of chromosome XII near SST2. A slight deleterious effect of a null mutation in either HMG-CoA reductase gene was detected by a co-cultivation experiment involving the wild-type strain and the two single mutants.
Ecteinascidin 743:  A Minor Groove Alkylator That Bends DNA toward the Major Groove (1999)

The ecteinascidins (Ets), which are natural products derived from marine tunicates, exhibit potent antitumor activity. Of the numerous Ets isolated, Et 743 is presently being evaluated in phase II clinical trials. Et 743 binds in the minor groove of DNA and alkylates N2 of guanine. Although structurally similar to saframycin, which exhibits poor activity in cellular assays, Et 743 has shown good efficacy as an antitumor agent. In this study, DNA structural distortions induced by Et 743 were examined to provide insight into the molecular basis for the antitumor activity of Et 743. Electrophoretic mobility shifts of ligated oligomers containing site-directed adducts were used to examine the extent and direction of the Et 743-induced bend. Surprisingly, we find that Et 743 bends DNA toward the major groove, which is a unique feature among DNA-interactive agents that occupy the minor groove.
1-bit stochastic gradient descent and its application to data-parallel distributed training of speech DNNs (2014)

We show empirically that in SGD training of deep neural networks, one can, at no or nearly no loss of accuracy, quantize the gradients aggressively—to but one bit per value—if the quantization error is carried forward across minibatches (error feedback). This size reduction makes it feasible to parallelize SGD through data-parallelism with fast processors like recent GPUs. We implement data-parallel deterministically distributed SGD by combining this finding with AdaGrad, automatic minibatch-size selection, double buffering, and model parallelism. Unexpectedly, quantization benefits AdaGrad, giving a small accuracy gain. For a typical Switchboard DNN with 46M parameters, we reach computation speeds of 27k frames per second (kfps) when using 2880 samples per minibatch, and 51kfps with 16k, on a server with 8 K20X GPUs. This corresponds to speed-ups over a single GPU of 3.6 and 6.3, respectively. 7 training passes over 309h of data complete in under 7h. A 160M-parameter model training processes 3300h of data in under 16h on 20 dual-GPU servers—a 10 times speed-up—albeit at a small accuracy loss.
Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock (1996)

Two genes, period (per) and timeless (tim), are required for production of circadian rhythms in Drosophila. The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. TIM accumulated rhythmically in nuclei of eyes and in pacemaker cells of the brain. The phase of these rhythms was differentially advanced or delayed by light pulses delivered at different times of day, corresponding with phase shifts induced in the behavioral rhythms.
Structure and regulation of tobacco extensin (1993)

A tobacco cDNA clone (pCNT1) was characterized that encodes an extensin apoprotein almost entirely composed of the repeats Ser-Pro4(-Lys2), Pro-Tyr2-Pro2-His and Thr-Pro-Val-Tyr-Lys. In healthy plants extensin transcripts are abundant in the roots, less prevalent in the stem and rare in the leaves. In leaves extensin mRNA is induced by wounding, ethylene or virus infection. Tobacco was transformed with pCNT1 cDNA coupled in sense or antisense orientation to the CaMV 35S promoter. Analysis of transgenic plants that over- or underexpressed pCNT1 mRNA demonstrated that the encoded protein constituted the majority of hydroxyproline-rich glycoproteins in roots, stems and leaves. The pCNT1-encoded protein contained at least 50% of total hydroxyproline present in these organs and was abundant in the soluble protein fraction of stems and roots as well as in the cell wall of stem vascular bundles. Analysis of transgenic plants expressing sense or antisense extensin gene constructs showed no correlation between total hydroxyproline concentration or soluble HRGP content and plant development.
The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. (1991)

To identify the region(s) of the insulin receptor and the insulin-like growth factor I (IGF-I) receptor responsible for ligand specificity (high-affinity binding), expression vectors encoding soluble chimeric insulin/IGF-I receptors were prepared. The chimeric receptors were expressed in mammalian cells and partially purified. Binding studies revealed that a construct comprising an IGF-I receptor in which the 68 N-terminal amino acids of the insulin receptor alpha-subunit had replaced the equivalent IGF-I receptor segment displayed a markedly increased affinity for insulin. In contrast, the corresponding IGF-I receptor sequence is not critical for high-affinity IGF-I binding. It is shown that part of the cysteine-rich domain determines IGF-I specificity. We have previously shown that exchanging exons 1, 2, and 3 of the insulin receptor with the corresponding IGF-I receptor sequence results in loss of high affinity for insulin and gain of high affinity for IGF-I. Consequently, it is suggested that the ligand specificities of the two receptors (i.e., the sequences that discriminate between insulin and IGF-I) reside in different regions of a binding site with common features present in both receptors.
A direct-recording ocean-bottom seismograph (1976)

abstract A direct-recording ocean-bottom seismograph featuring small size and low cost has been constructed and operated in the deep ocean. The design consists of a cylindrical instrument package 15 cm in diameter and 53 cm long. Signals from a gimbal-mounted 2-Hz vertical geophone and a hydrophone are amplified and direct-recorded at different gain levels on three channels of 6.4-mm wide magnetic tape. BCD-coded time pulses, generated from a crystal oscillator signal, are recorded on the fourth channel. The instrument has its maximum displacement response at 17 Hz. Tape consumption is 22 m/day (0.01 ips) from 12.7-cm reels permitting continuous recording for up to 12.5 days. CMOS electronics are used throughout and, together with a low-power tape drive motor, the unit requires less than 100 mW of power. This permits long recording times from 9 D-cell alkaline batteries. Syntactic foam flotation, good to 6400 m, permits a low-profile design 1.0 m long and 0.7 m high. It weights 114 kg in air and descent and rise rates are 0.64 m/sec. For retrieval, an expendable base plate is released by a cable cutter on command from a clock comparator circuit. Data playback is at 10 to 100 times recorded speed.
Photochemical reaction of imidazoles with unsaturated nitriles. Chemistry of encounter complex and ion pair (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemical reaction of imidazoles with unsaturated nitriles. Chemistry of encounter complex and ion pairYoshikatsu Ito and Teruo MatsuuraCite this: J. Org. Chem. 1979, 44, 1, 41–49Publication Date (Print):January 1, 1979Publication History Published online1 May 2002Published inissue 1 January 1979https://pubs.acs.org/doi/10.1021/jo01315a012https://doi.org/10.1021/jo01315a012research-articleACS PublicationsRequest reuse permissionsArticle Views363Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Capacity and flow assignment issues in MPLS networks (2003)

Abstract MPLS technology enables IP networks to accept the challenge raised by emerging communication paradigms. This paper describes a nonlinear model with path capacity as design variables and space priority as constraints. The analysis shows that the close‐form solution exists if traffic flows are allocated by an independent protocol. Copyright © 2003 John Wiley &amp;Sons, Ltd.
The Dolastatins. 19. Synthesis of Dolaisoleuine (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Dolastatins. 19. Synthesis of DolaisoleuineGeorge R. Pettit, Sheo Bux Singh, Jayaram K. Srirangam, Fiona Hogan-Pierson, and Michael D. WilliamsCite this: J. Org. Chem. 1994, 59, 7, 1796–1800Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/jo00086a034https://doi.org/10.1021/jo00086a034research-articleACS PublicationsRequest reuse permissionsArticle Views812Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fourier transform time-of-flight mass spectrometry (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFourier transform time-of-flight mass spectrometryFritz J. Knorr, Massoud. Ajami, and Dale A. ChatfieldCite this: Anal. Chem. 1986, 58, 4, 690–694Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ac00295a007https://doi.org/10.1021/ac00295a007research-articleACS PublicationsRequest reuse permissionsArticle Views269Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prognostic relevance of microvessel density in colorectal tumours. (1999)

The importance of angiogenesis as a prognostic marker has been examined in 111 colorectal cancer patients with a minimum follow-up of 5 years. Tumour sections were immunostained with pan-endothelial antibody to CD31. Microvessels were identified and counted in 5 separate areas of highest vascularity (<hot spots>). Analysis of the data showed that the survival was not significantly affected by tumour site, size, grade, patients' age or gender. However, a statistically significant correlation was found between microvessel density (MVD) and survival: patients with an increased number of microvessels survived longer than those with a low number of microvessels (p=0.0007). Therefore, paradoxically, unlike other tumour types, in colorectal cancer MVD appears to be an indicator of good prognosis. The reasons that MVD correlates with good or poor prognosis are likely to vary in different tumours. For instance a frequent difficult issue in colon cancer is the presence of ulceration and adjacent severe inflammation which by itself can increase vascularity. Furthermore, overall prognosis will also depend on other factors, such as oncogenes, extracellular matrix components, adhesion molecules, growth factors, degree of apoptosis and the mode of metastatic spread.
Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double‐blind placebo‐controlled multicenter trial (2009)

Although time to CDP between groups was not significant, overall subgroup analyses suggest selective B-cell depletion may affect disease progression in younger patients, particularly those with inflammatory lesions.
Nonmetric calibration of camera lens distortion using concentric circles pattern (2010)

A method of distortion calibration for camera is proposed. The distortion center and distortion coefficients are estimated separately. The planar concentric circles are used as the calibration pattern. By analyzing the geometrical and projective characters of concentric circles, we deduce that the line connecting the centroids of distorted concentric circles must go through the distortion center. This is utilized to compute the distortion parameters and the solution in the sense of least square are obtained. The proposed approach is entirely noniterative, therefore it keeps away from the procedure of iterative optimization. On the other hand, it is nonmetric, thus it is low cost. Experiments on both synthetic and real image data are reported. The results show our method behaves excellently. Moreover, the capability of our method to resist noise is satisfying.
Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes (2007)

Although fatty acids enhance preadipocyte differentiation in the presence of adequate hormone cocktails, little is known regarding their effects in the absence of these hormones. We have now shown that palmitate, a common long-chain saturated fatty acid, induced apoptosis in both mouse 3T3-L1 and rat primary preadipocytes grown in a normal serum-containing medium. Treatment of preadipocytes with palmitate induced multiple endoplasmic reticulum (ER) stress responses, evidenced by increased protein content of CHOP and GRP78 and splicing of XBP-1 mRNA, as well as altered phosphorylation of eIF2alpha and increased phosphorylation of JNK and Erk1/2. Intriguingly, palmitate induced an early activation of Akt but diminished both Akt activation and its protein mass after prolonged incubation (>6 h). In association with these changes, palmitate reduced expression of beta-catenin and its downstream target, c-Myc and cyclin D1, two key prosurvival proteins. Overexpression of constitutively active Akt did not block the apoptotic effect of palmitate. Cotreatment with unsaturated fatty acids (oleate, linoleate) or with LiCl (a glycogen synthase kinase-3beta inhibitor) attenuated the palmitate-induced apoptosis. Subsequent analysis suggested that the unsaturated fatty acids probably counteracted palmitate by reducing, not eliminating, ER stress, whereas LiCl probably improved viability by activating the Wnt signaling pathway. Cotreatment of palmitate with a standard adipogenic hormone cocktail also abolished the apoptotic effect and promoted adipocyte differentiation. Collectively, our results suggest that palmitate causes multiple cellular stresses that may lead to apoptosis in preadipocytes in the absence of adipogenic stimuli, highlighting the importance of exogenous hormones in directing cell fate in response to increased fatty acid influx.
Native ribonucleoprotein is an efficient transcriptional complex of avian myeloblastosis virus. (1980)

A native ribonucleoprotein (RNP) complex of avian myeloblastosis virus was prepared under conditions that gave optimal cDNA synthesis. The complex was an autonomous transcriptional unit capable of synthesizing DNA complementary to the RNA virus genome in the absence of exogenous reverse transcriptase (RNA-dependent DNA nucleotidyltransferase), genomic RNA, and primer. The RNA of the RNP complex cannot be translated in an in vitro cell-free translational system. The RNP contains intact viral RNA, the two subunits of the reverse transcriptase (beta and alpha), the p32 polypeptide resulting from the cleavage of the beta subunit into the alpha subunit, and p12. The principal polypeptide constituent of the RNP complex is the highly basic protein p12, which occurs at a molar ratio of 40:1 in relation to the beta subunit of the polymerase. When examined by the electron microscope, the RNP complex appears similar to the beaded structure of chromatin fiber. A significant portion of these molecules are circular, with headlike structures attached. The circular nature of the proviral DNA and the ability of the RNP complex to generate large intact cDNA copies from the natural primer end suggest that the 5' and 3' ends of the viral RNA are in proximity when in the RNP complex.
Isolation and Characterization of Mesenchymal Stem Cells from Human Amniotic Membrane (2010)

Our data demonstrated the successful isolation of hAMSCs from full-term placentas using two published protocols. Differences between the two protocols in cell yield and in vitro differentiation potential are shown.