gebhart/patrepeval huggingface dataset:
A frameless stereotaxic integration of computerized tomographic imaging and the operating microscope (1986)

A computer-based system has been developed for the integration and display of computerized tomography (CT) image data in the operating microscope in the correct perspective without requiring a stereotaxic frame. Spatial registration of the CT image data is accomplished by determination of the position of the operating microscope as its focal point is brought to each of three CT-imaged fiducial markers on the scalp. Monitoring of subsequent microscope positions allows appropriate reformatting of CT data into a common coordinate system. The position of the freely moveable microscope is determined by a non-imaging ultrasonic range-finder consisting of three spark gaps attached to the microscope and three microphones on a rigid support in the operating room. Measurement of the acoustic impulse transit times from the spark gaps to the microphones enables calculation of those distances and unique determination of the microscope position. The CT data are reformatted into a plane and orientation corresponding to the microscope's focal plane or to a deeper parallel plane if required. This reformatted information is then projected into the optics of the operating microscope using a miniature cathode ray tube and a beam splitter. The operating surgeon sees the CT information (such as a tumor boundary) superimposed upon the operating field in proper position, orientation, and scale.
The Relative Toxicity of Substituted Phenols Reported in Cigarette Mainstream Smoke (2002)

Cigarette mainstream smoke (MS) contains a number of structurally diverse substituted phenols. Recent quantitative structure activity relationship (QSAR) studies on phenols show that substituted phenols with electron-releasing groups can form potentially toxic phenoxyl-free radicals. In contrast, substituted phenols with electron-withdrawing groups do not form phenoxyl-free radicals but exert their toxicity primarily through lipophilicity. The chemical structures of 253 different substituted phenols reported in MS have been described in sufficient detail to allow identification of the individual compounds. From a laterally validated equation based on published data on the toxic effects of phenols on cultured cells, the relative toxicity, on a molar basis, of the 253 MS phenols has been determined. Based on this scheme, the most toxic phenols in MS include, in descending order of toxicity, 2-(dimethylamino)-phenol, 2-ethyl-6-methyl-1,4-benzenediol, 2-methoxy-1,4-benzenediol, and 4-ethyl-2-methoxy-6-methylphenol. The least toxic phenols include, in ascending order of toxicity, 4-hydroxybenzoic acid and 3-hydroxybenzenepropanoic acid. In the human exposure situation, the toxicity of MS phenols is a complex interaction, with contributions made by the following factors: toxicity per mole; MS concentration; synergistic, additive or antagonistic interactions with other MS components; host susceptibility; metabolism; and individual smoking behavior and inhalation patterns. In the absence of data to the contrary, reduction in the number and concentration of toxic MS smoke components may be considered to be advantageous. Studies of this type can play an important role in identifying MS components for reduction or removal.
Tumor trailing strategy for intensity‐modulated radiation therapy of moving targets (2008)

Internal organ motion during the course of radiation therapy of cancer affects the distribution of the delivered dose and, generally, reduces its conformality to the targeted volume. Previously proposed approaches aimed at mitigating the effect of internal motion in intensity-modulated radiation therapy (IMRT) included expansion of the target margins, motion-correlated delivery (e.g., respiratory gating, tumor tracking), and adaptive treatment plan optimization employing a probabilistic description of motion. We describe and test the tumor trailing strategy, which utilizes the synergy of motion-adaptive treatment planning and delivery methods. We regard the (rigid) target motion as a superposition of a relatively fast cyclic component (e.g., respiratory) and slow aperiodic trends (e.g., the drift of exhalation baseline). In the trailing approach, these two components of motion are decoupled and dealt with separately. Real-time motion monitoring is employed to identify the "slow" shifts, which are then corrected by applying setup adjustments. The delivery does not track the target position exactly, but trails the systematic trend due to the delay between the time a shift occurs, is reliably detected, and, subsequently, corrected. The "fast" cyclic motion is accounted for with a robust motion-adaptive treatment planning, which allows for variability in motion parameters (e.g., mean and extrema of the tidal volume, variable period of respiration, and expiratory duration). Motion-surrogate data from gated IMRT treatments were used to provide probability distribution data for motion-adaptive planning and to test algorithms that identified systematic trends in the character of motion. Sample IMRT fields were delivered on a clinical linear accelerator to a programmable moving phantom. Dose measurements were performed with a commercial two-dimensional ion-chamber array. The results indicate that by reducing intrafractional motion variability, the trailing strategy enhances relevance and applicability of motion-adaptive planning methods, and improves conformality of the delivered dose to the target in the presence of irregular motion. Trailing strategy can be applied to respiratory-gated treatments, in which the correction for the slow motion can increase the duty cycle, while robust probabilistic planning can improve management of the residual motion within the gate window. Similarly, trailing may improve the dose conformality in treatment of patients who exhibit detectable target motion of low amplitude, which is considered insufficient to provide a clinical indication for the use of respiratory-gated treatment (e.g., peak-to-peak motion of less than 10 mm). The mechanical limitations of implementing tumor trailing are less rigorous than those of real-time tracking, and the same technology could be used for both.
Dominant type 1 von Willebrand disease caused by mutated cysteine residues in the D3 domain of von Willebrand factor (1996)

No defects have been reported in moderately severe type 1 von Willebrand disease (vWD) with a clear autosomal dominant inheritance pattern, and the mechanism underlying this form of vWD remains obscure. We have studied a type 1 vWD family with such a dominant phenotype. The entire coding sequence of the von Willebrand factor (vWF) gene was analyzed by direct sequencing of DNA fragments amplified by polymerase chain reaction. Only one candidate mutation T(3445)-->C in exon 26 was detected that predicts a replacement of cysteine (C) at position 386 of the mature vWF subunit by arginine (R). Both mutant and normal vWF alleles were expressed as shown by analysis of platelet mRNA. This substitution segregates with vWD in the family and was not found in 100 unrelated individuals. The recombinant mutant vWF(C386R) was characterized by expression in 293T cells. The secretion of vWF(C386R) was greatly impaired due to retention in the endoplasmic reticulum. In cotransfections of normal and mutant vWF constructs, the vWF(C386R) subunits caused a dose-dependent decrease in the secretion of vWF. The multimer pattern remained nearly normal and consistent with a dominant vWD type 1 phenotype. The importance of the cysteine residues in the D3 domain of vWF in the pathogenesis of dominant type 1 vWD was further shown by the detection of another cysteine mutation, Cys367-->Phe, in two additional unrelated patients with a similar dominant type 1 vWD phenotype. We conclude that the loss of cysteine pairing in the D3 domain, leaving one free cysteine, can induce a purely quantitative deficiency of vWF by dominantly suppressing the secretion of normal vWF.
Phase Behavior and Rheology of SWNTs in Superacids (2003)

Single-walled carbon nanotubes (SWNTs) can be dispersed at high concentration in superacids; the protonation of SWNTs sidewalls eliminates wall−wall van der Waals interactions and promotes the dispersion process. At very low concentration, SWNTs in superacids dissolve as individual tubes which behave as Brownian rods. At higher concentration, SWNTs form a highly unusual nematic phase consisting of spaghetti-like self-assembled supermolecular strands of mobile, solvated tubes in equilibrium with a dilute isotropic phase. At even higher concentration, the spaghetti strands self-assemble into a polydomain nematic liquid crystal. Upon the introduction of small amounts of water, the liquid crystal phase separates into needle-shaped strands (∼20 μm long) of highly aligned SWNTs, termed alewives. Under anhydrous condition, the liquid crystalline phase can be processed into highly aligned fibers of pure SWNT without the aid of any surfactants or polymers.
Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells. (1989)

The polymeric immunoglobulin receptor (pIg-R) is responsible for the receptor-mediated transcytosis of polymeric immunoglobulins (IgA and IgM) across various epithelia. We have expressed the cDNA for the pIg-R in Madin-Darby canine kidney (MDCK) cells and found that this system mimics that found in vivo (Mostov, K. E., and D. L. Deitcher. 1986. Cell. 46:613-621). We have now investigated the postendocytotic pathway of the ligand for the pIg-R. After a 5-min internalization at the basolateral surface, approximately 45% of internalized ligand recycles to the basolateral medium and 30% is transcytosed to the apical medium. We have also examined why transcytosis of ligand is unidirectional, going only from basolateral to apical, but not from apical to basolateral. Several factors could explain this, such as proteolytic cleavage of the pIg-R at the apical surface, decreased apical endocytosis of ligand, or an intracellular sorting event. In this report, we show that the protease inhibitor, leupeptin, inhibits the cleavage of the pIg-R but does not alter the unidirectionality of transcytosis. In addition, we demonstrate that there is a significant amount of apical endocytosis of ligand (70% of that observed basolaterally). Finally, we demonstrate that apically endocytosed ligand can return only to the apical surface. Thus, once ligand reaches the apical surface, it is "trapped" and cannot return to the basolateral surface. We propose that the unidirectionality of transcytosis is the result of intracellular sorting, and that this results from a signal(s) present on the pIg-R.
Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours (2016)

E-liquids generally contain four main components: nicotine, flavours, water and carrier liquids. The carrier liquid dissolves flavours and nicotine and vaporises at a certain temperature on the atomizer of the e-cigarette. Propylene glycol and glycerol, the principal carriers used in e-liquids, undergo decomposition in contact with the atomizer heating-coil forming volatile carbonyls. Some of these, such as formaldehyde, acetaldehyde and acrolein, are of concern due to their adverse impact on human health when inhaled at sufficient concentrations. The aim of this study was to correlate the yield of volatile carbonyls emitted by e-cigarettes with the temperature of the heating coil. For this purpose, a popular commercial e-liquid was machine-vaped on a third generation e-cigarette which allowed the variation of the output wattage (5–25 W) and therefore the heat generated on the atomizer heating-coil. The temperature of the heating-coil was determined by infrared thermography and the vapour generated at each temperature underwent subjective sensorial quality evaluation by an experienced vaper. A steep increase in the generated carbonyls was observed when applying a battery-output of at least 15 W corresponding to 200–250 °C on the heating coil. However, when considering concentrations in each inhaled puff, the short-term indoor air guideline value for formaldehyde was already exceeded at the lowest wattage of 5 W, which is the wattage applied in most 2nd generation e-cigarettes. Concentrations of acetaldehyde in each puff were several times below the short-term irritation threshold value for humans. Acrolein was only detected from 20 W upwards. The negative sensorial quality evaluation by the volunteering vaper of the vapour generated at 20 W demonstrated the unlikelihood that such a wattage would be realistically set by a vaper. This study highlights the importance to develop standardised testing methods for the assessment of carbonyl-emissions and emissions of other potentially harmful compounds from e-cigarettes. The wide variety and variability of products available on the market make the development of such methods and the associated standardised testing conditions particularly demanding.
SA division annual report 2015 (2015)

The South Australian Division of Ag Institute Australia has been active providing events, information and awards for our South Australian members. Our aim has been to help build value in the membership beyond the activities of National Office such as the weekly alert, the Journal, accreditation, professional representation and national events.
Mixed Monolayer-Protected Gold Nanoclusters as Selective Peptide Extraction Agents for MALDI-MS Analysis (2006)

Cationic and anionic nanoparticles selectively target peptides with low and high isoelectric points, respectively. Additionally, their high surface area-to-volume ratios make these nanoparticles (approximately 2-nm core diameter) very efficient extraction and concentration agents. Upon extraction, the peptide-bound nanoparticles can be analyzed by MALDI-MS to provide highly sensitive detection of the targeted peptides. We demonstrate that MALDI-MS can detect peptide concentrations as low as 500 pM from 250-microL solutions using these nanoparticle scaffolds as extraction and concentration agents.
Meeting the Challenge for Automated Hexahedral Meshing (invited). (2000)

The clinical goals of HIV treatment are optimally accomplished through consistent high-level adherence to highly active antiretroviral therapy (HAART) and durable suppression of the viral load. However, as a result of the need for lifelong therapy and HIV's prodigious replication rate and error-prone reverse transcriptase, varying amounts of antiretroviral drug resistance are common in treated individuals. Medication adherence is linked to the development of drug resistance, although not by a simple linear relationship. Recent studies have suggested that extensive drug resistance is not a major determinant of HIV disease progression and death. Rather, failure to access care and discontinuation of or non-adherence with therapy are arguably the most important factors associated with HIV disease progression in the HAART era. Other data indicate that continued therapy in the setting of extensive drug resistance and the inability to achieve viral suppression can provide continued clinical benefit. Such benefit may be mediated, at least partially, by reductions in viral fitness associated with drug resistance mutations.
A Meta-analysis of Clinical Screening Tests for Obstructive Sleep Apnea (2009)

The purpose of this meta-analysis is to compare clinical screening tests for obstructive sleep apnea and establish an evidence base for their preoperative use. Diagnostic odds ratios were used as summary measures of accuracy, and false-negative rates were used as measures of missed diagnosis with each screening test in this review. Metaregression revealed that clinical models, logarithmic equations, combined techniques, cephalometry, and morphometry are significant characteristics, whereas body mass index, history of hypertension, and nocturnal choking are significant test elements associated with higher diagnostic accuracy. Test accuracy in repeated validation studies of the same screening test is variable, suggesting an underlying heterogeneity in either the clinical presentation of obstructive sleep apnea or the measured clinical elements of these models. Based on the false-negative rates, it is likely that most of the clinical screening tests will miss a significant proportion of patients with obstructive sleep apnea.
Heterogeneous catalytic synthesis of ethanol from biomass-derived syngas (2007)

The selective catalytic conversion of biomass-derived syngas into ethanol is thermodynamically feasible at temperatures below roughly 350 degrees C at 30 bar. However, if methane is allowed as a reaction product, the conversion to ethanol (or other oxygenates) is extremely limited. Experimental results show that high selectivities to ethanol are only achieved at very low conversions, typically less than 10%. The most promising catalysts for the synthesis of ethanol are based on Rh, though some other formulations (such as modified methanol synthesis catalysts) show promise.
Soluble Human Cytomegalovirus gH/gL/pUL128–131 Pentameric Complex, but Not gH/gL, Inhibits Viral Entry to Epithelial Cells and Presents Dominant Native Neutralizing Epitopes (2015)

Congenital infection of human cytomegalovirus (HCMV) is one of the leading causes of nongenetic birth defects, and development of a prophylactic vaccine against HCMV is of high priority for public health. The gH/gL/pUL128-131 pentameric complex mediates HCMV entry into endothelial and epithelial cells, and it is a major target for neutralizing antibody responses. To better understand the mechanism by which antibodies interact with the epitopes of the gH/gL/pUL128-131 pentameric complex resulting in viral neutralization, we expressed and purified soluble gH/gL/pUL128-131 pentameric complex and gH/gL from Chinese hamster ovary cells to >95% purity. The soluble gH/gL, which exists predominantly as (gH/gL)2 homodimer with a molecular mass of 220 kDa in solution, has a stoichiometry of 1:1 and a pI of 6.0-6.5. The pentameric complex has a molecular mass of 160 kDa, a stoichiometry of 1:1:1:1:1, and a pI of 7.4-8.1. The soluble pentameric complex, but not gH/gL, adsorbs 76% of neutralizing activities in HCMV human hyperimmune globulin, consistent with earlier reports that the most potent neutralizing epitopes for blocking epithelial infection are unique to the pentameric complex. Functionally, the soluble pentameric complex, but not gH/gL, blocks viral entry to epithelial cells in culture. Our results highlight the importance of the gH/gL/pUL128-131 pentameric complex in HCMV vaccine design and emphasize the necessity to monitor the integrity of the pentameric complex during the vaccine manufacturing process.
Peak Power Characteristics of Single Carrier FDMA MIMO Precoding System (2007)

A salient advantage of single carrier frequency division multiple access (SC-FDMA) is low peak-to-average power ratio (PAPR) which is lower than that of OFDMA. Precoding using transmit beamforming (TxBF) is a MIMO spatial multiplexing method that increases the data throughput significantly. However, when applied to SC-FDMA, it increases the PAPR. In this paper, we describe how we can apply TxBF to an SC-FDMA system and show its effect on PAPR We then consider the effects of precoder averaging across subcarriers and quantization, typically used to reduce feedback overhead, on the PAPR Comparisons are made with single antenna, non-precoded spatial multiplexing (SM) and space-frequency block coding (SFBC) systems. Lastly, we show that a modest amount of amplitude clipping can reduce PAPR to an acceptable level with virtually no harmful effects on performance or spectral growth.
Novel surfactants : preparation, applications, and biodegradability (1998)

N-Alkanoyl-N-Alkyl-1-Glycamines: Robert G. Laughlin, Y.-C. Fu, F.C. Wireko, J.J. Scheibel, and R.L. MunyonAlkyl Polyglycosides: Wolfgang von Rybinski and Karlheinz HillSugar Fatty Acid Esters: Calum J. Drummond, Celesta Fong, Irena Krodkiewska, Ben J. Boyd, and Irene J.A. BakerNovel Saccharide-Based Surfactants: Bogdan BurczykAmino Acid-Based Surfactants: Maria Rosa Infante, Lourdes P?rez, Aurora Pinazo, Pere Clap?s, and Maria Del Carmen Mor?nSurfactants Based on Sterols and Other Alicyclic Compounds: Martin Svensson and Johanna BrinckFatty Acid Monoethanol Amide Ethoxylates: Britta FolmerEnzymatic Synthesis of Surfactants: Evgeny VulfsonSurfactants Produced by Microorganisms: Siegmund LangCleavable Surfactants: Maria Stjerndahl, Dan Lundberg, and Krister HolmbergEsterquats: Cor Overkempe, Annika Annerling, C.G. van Ginkel, Paul Christopher Thomas, Dagmar Boltersdorf, and Johanna SpeelmanGemini Surfactants: R.R. Zana and El Ouafi AlamiAlpha-Sulfomonocarboxylic Esters: Hans Lewansdowski and M.J. SchwugerMethyl Ester Ethoxylates: Michael F. Cox and Upali WeerasoorijaPolymerizable Surfactants: Alain GuyotPolymeric Surfactants: Tharwat TadrosSilicone Surfactants: Ingo Fleute-Schlachter and Georg Feldmann-KraneIndex
A novel VLC based on second-run-level coding and dynamic truncation (2006)

In this paper, a novel VLC method based on 2nd-run-level coding and dynamic truncation is proposed to compress the DCT coefficients efficiently. In the proposed VLC, 2nd-run-level is first employed, following the traditional run-level coding, to further reduce the considerable redundancy existing in the original level and run sequences. In order to achieve a higher degree of context adaptability and coding efficiency, dynamic truncation is introduced and employed in the sequential coding of 2D symbols without large amounts of 2D-VLC tables required, though adding extra coding complexity to some extent. Adaptive EG/GR selection is also presented and recommended since it brings extra improvement in compression efficiency without increasing any computational complexity. Experimental results show that when compared with context-based 2D-VLC, the proposed VLC method gains 0.25 dB ~0.79 dB in PSNR and achieves 5.30% ~ 11.58% improvement in bit rate reduction.
Study on Aromatic Phosphines for Novel Fluorometry of Hydroperoxides (I) -Synthesis and Spectral Properties of Diphenyl Aryl Phosphines and Their Oxides (1987)

Abstract 1-Naphthyldiphenylphosphine (NDPP), 9-anthryldiphenylphosphine (ADPP) and diphenyl-1-pyrenylphosphine (DPPP) and their oxides were prepared from triphenyl-phosphine (TPP) and the corresponding aryl bromides. These phosphines had no fluorescence, but their oxides showed blue fluorescence. The order of fluorescence intensities of these oxides were DPPP oxide > ADPP oxide > NDPP oxide. Hydroperoxides oxidized these phosphines to the corresponding oxides quantitatively. The relative reactivities were TPP > NDPP > DPPP > ADPP. The phosphines were stable in the dark, however, unstable in the light in chloroform. The reaction is proposed as novel type of fluorometry for hydroperoxides.
3D surface estimation and model construction from specular motion in image sequences (1997)

This work reconstructs a 3D graphics model of an object with specular surfaces by its rotation. Continuous images are taken to measure highlights on the smooth surfaces and their motion. Coplanar extended lights determine a plane of rays to produce a highlight stripe on the object. 3D surfaces are then recovered from the moving stripe. We investigate global motion characteristics of the highlights in the epipolar-plane images so as to qualitatively identify surface types and control the modeling process. Under single and multiple plane-of-rays illuminations, we give two quantitative approaches for surface and normal recovery which use highlight orientation in the image and highlight motion in the epipolar-plane images. The computations employ a first-order differential equation and linear equations, respectively.