gebhart/patrepeval huggingface dataset:
Towards the Integration of Carbon nanostructures into CMOS technology (2005)

Relentless efforts for miniaturization of traditional complementary metal oxide semiconductor (CMOS) devices have reached the limit where the device characteristics are governed by quantum phenomena which are difficult to control. This engendered a need for finding alternative new materials that can be engineered to fabricate devices that will possess at least the same or even better performance than existing CMOS devices. The choices of new material(s) is however limited by factors like production compatibility, reproducibility and cost efficiency. The scientific endeavor made in this thesis was focused on the technological requirements and issues related to integration of novel materials into a CMOS platform and developing potential solutions to some of the technological difficulties. Front end technology developed in this work includes interfacing molecules, gold clusters and carbon nanotubes. We have explored the quasi one-dimensional nature of these materials in combination with e. g. self assembling techniques, surface treatments, nanolithography and the scanning probe technique. A general understanding derived from the device characteristics is that the electrical characteristics of an electronic nano-device not only depends on the intrinsic properties of the materials but is also strongly correlated with the method of device fabrication. Probing the intrinsic property of the material is challenging since the interface between the material and the microscopic leads governs the device characteristics. The technological development of the vertical growth of the carbon nanofibers (CNFs) presented in this work is applicable to tackle the technological difficulties envisaged for the back end technology beyond the year 2010. At the early stage of the work technology was developed to selectively grow CNF on a silicon substrate with diverse topography. Extending the same technology towards CMOS integration faced problem with growth on candidate metals. The challenge was met by introducing a thin layer of a-Si as a part of the catalyst layer which actually boosted the growth on Pt, Pd, W and Mo metal underlayers. However the problem remains for Ti and Cr metal underlayers which is in apparent contradiction to results obtained by other groups. The developed technology can be explored to fabricated vertical nanorelay devices or electrochemical probes.
Murine models of normal and neoplastic human haematopoiesis. (1992)

The ability to transplant human haematopoietic cells into immune deficient mice provides a unique opportunity for studying the organization and regulation of the human stem cell developmental program. One challenge for the future will be to reconstitute mice with functional cells of all lineages. The creation of animal models of many haematopoietic diseases should revolutionize the development and testing of novel therapeutic strategies. Significant progress has been made in establishing models of human neoplastic diseases such as leukaemia and lymphoma. Although the number of patients examined is still small, it appears that there may be a correlation between growth in immune deficient mice and clinical outcome. Future studies should examine the range of diseases that grow in mice and whether in vivo assays have prognostic value clinically. These leukaemia models, in conjunction with high efficiency gene transfer techniques, offer a powerful approach to examine the biological consequences of expressing oncogenes or other key regulatory genes on human leukaemic transformation and progression.
One Factor Recognizes the Liver-Specific Enhancers in α 1 -Antitrypsin and Transthyretin Genes (1988)

Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.
GM2 Ganglioside as a Regulator of Pyramidal Neuron Dendritogenesisa (1998)

One of the most profound events in the life of a neuron in the mammalian CNS is the development of a characteristic dendritic tree, yet little is understood about events controlling this process. Pyramidal neurons of the cerebral cortex are known to undergo a single explosive burst of dendritic sprouting immediately after completing migration to the cortical mantle, and following maturation there is no evidence that new, primary dendrites are initiated. Yet in one group of rare genetic diseases--Tay-Sachs disease and related neuronal storage disorders--cortical pyramidal neurons undergo a second period of dendritogenesis. New dendritic membrane is generated principally at the axon hillock and in time is covered with normal-appearing spines and synapses. In our studies of normal brain development and storage diseases we consistently find one feature in common in cortical pyramidal neurons undergoing active dendritogenesis: They exhibit dramatically increased expression of GM2 ganglioside localized to cytoplasmic vacuoles within neuronal perikarya and proximal dendrites. There is also evidence that the increase in GM2 precedes dendritic spouting, and that after dendritic maturation is complete (in normal brain) the GM2 levels in neurons become substantially reduced. These findings are consistent with GM2 ganglioside playing a pivotal role in the regulation of dendritogenesis in cortical pyramidal neurons.
Wireless integrated network sensors (2000)

For pervasive computing performance, exploit the physical limits of these densely distributed networks of embedded sensors, controls, and processors. W ireless integrated network sensors (WINS) provide distributed network and Internet access to sensors, controls, and processors deeply embedded in equipment, facilities, and the environment. The WINS network represents a new monitoring and control capability for applications in such industries as transportation, manufacturing, health care, environmental oversight, and safety and security. WINS combine microsensor technology and low-power signal processing, computation, and low-cost wireless networking in a compact system.
Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury (2008)

Failure of axon regeneration in the mammalian CNS is attributable in part to the presence of various inhibitory molecules, including myelin-associated proteins and proteoglycans enriched in glial scars. Here, we evaluate whether axon guidance molecules also regulate regenerative growth after injury in adulthood. Wnts are a large family of axon guidance molecules that can attract ascending axons and repel descending axons along the length of the developing spinal cord. Their expression (all 19 Wnts) is not detectable in normal adult spinal cord by in situ hybridization. However, three of them are clearly reinduced after spinal cord injury. Wnt1 and Wnt5a, encoding potent repellents of the descending corticospinal tract (CST) axons, were robustly and acutely induced broadly in the spinal cord gray matter after unilateral hemisection. Ryk, the conserved repulsive Wnt receptor, was also induced in the lesion area, and Ryk immunoreactivity was found on the lesioned CST axons. Wnt4, which attracts ascending sensory axons in development, was acutely induced in areas closer to the lesion than Wnt1 and Wnt5a. Injection of function-blocking Ryk antibodies into the dorsal bilateral hemisectioned spinal cord either prevented the retraction of CST axons or promoted their regrowth but clearly enhanced the sprouting of CST collateral branches around and beyond the injury site. Therefore, repulsive Wnt signaling may be a cause of cortical spinal tract axon retraction and inhibits axon sprouting after injury.
Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). (1987)

Lymphokine activities in conditioned medium from activated helper T cell lines are most commonly defined by the proliferation of "specific" lymphokine-dependent cell lines. Various sublines of IL 2-dependent (and ostensibly specific) HT-2 and CTLL cells have now been shown to proliferate in response to BSF-1/IL 4 as well. After activation with antigen or mitogen, D10.G4.1, an antigen-specific cloned T helper cell that has recently been shown to produce IL 4 but not IL 2, secretes two distinct cytokines that induce the growth of HT-2 cells. These "T cell growth factors" (TCGF) can be separated by reversed phase high-performance liquid chromatography (RP-HPLC). The TCGF activity of one of these factors can be blocked by 11B11, an antibody specific for IL 4. The second TCGF activity is not affected by 11B11 or by antibodies specific for IL 2. This TCGF activity can be neutralized by a goat polyclonal antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF), and has a RP-HPLC elution profile identical to that of recombinant GM-CSF. Recombinant GM-CSF induces both proliferation and long-term growth of HT-2 but not CTLL cells, and this activity can be neutralized by the same antibody to GM-CSF. GM-CSF is best known as a factor that induces the maturation and growth of granulocytes and macrophages from bone marrow-derived hematopoietic precursor cells. The ability of GM-CSF to induce the growth of certain T cell lines indicates that this molecule may play a role in T cell-mediated immune responses, either as an autocrine growth factor or a paracrine stimulus from both lymphoid and nonlymphoid tissues that produce this cytokine.
Expression of nerve growth factor receptors is correlated with progression and prognosis of human pancreatic cancer (2006)

The present study found that the expression of TrkA in pancreatic cancer is a marker of tumor aggressiveness. Conversely, we also found that elevated p75NGFR expression is associated with a favorable prognosis. We demonstrated that NGF exerts both stimulatory and inhibitory effects on pancreatic cancers, with the overall effect determined by the expression levels and the ratio of TrkA to p75NGFR.
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. (1984)

Dexamethasone and corticosterone kill mouse thymocytes, as measured by eosin uptake, after several hours of in vitro incubation. This killing requires RNA and protein synthesis, because it is inhibited by cycloheximide, emetine, or actinomycin D. An earlier event than cell death is the extensive fragmentation of nuclear DNA into oligonucleosomal subunits; this fragmentation also requires RNA and protein synthesis. The DNA cleavage results from the action of an endonuclease that preferentially cleaves DNA in the linker regions between nucleosomes. This endonuclease is found constitutively in the nuclei of thymocytes and some other cells, and requires calcium and magnesium ions for its activation; if isolated fresh thymocyte nuclei are incubated with these ions, as much as 77% of their DNA is cleaved within 90 min. Thus, the protein for which synthesis is necessary for glucocorticoid-induced thymocyte death is not the endonuclease itself, but is in some way involved in its activation; we suggest that it may be part of a system for transporting calcium into the nucleus. The endonuclease is inhibited by zinc, which also prevents thymocyte death. It appears that glucocorticoids cause thymocyte death by activating an enzyme that rapidly and extensively degrades DNA. This "death from within" is biochemically and morphologically different from toxic or accidental cell death, such as that induced by azide, heat, or antibody and complement treatment. Although mature T cells also contain the endogenous endonuclease, they lack the glucocorticoid-inducible mechanism for activating it, and are thus glucocorticoid-resistant.
Hierarchical unsupervised learning of facial expression categories (2002)

We consider the problem of unsupervised classification of temporal sequences of facial expressions in video. This problem arises in the design of an adaptive visual agent, which must be capable of identifying appropriate classes of visual events without supervision to effectively complete its tasks. We present a multilevel dynamic Bayesian network that learns the high-level dynamics of facial expressions simultaneously, with models of the expressions themselves. We show how the parameters of the model can be learned in a scalable and efficient way. We present preliminary results using real video data and a class of simulated dynamic event models. The results show that our model correctly classifies the input data comparably to a standard event classification approach, while also learning the high-level model parameters.
A copper-clad lithiophilic current collector for dendrite-free lithium metal anodes (2019)

A flexible copper-clad lithiophilic current collector was designed for high coulombic efficiency dendrite-free Li metal anodes.
G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke (2010)

G-CSF was neuroprotective when given early after TE. Early combination with rt-PA showed no additional benefit compared to rt-PA or G-CSF alone, but did not lead to side effects. Pretreatment by G-CSF was able to reduce deleterious effects of late rt-PA treatment.
Substrate cycles in metabolic regulation and in heat generation. (1976)

1. The presence of substrate cycles in tissues has been demonstrated by direct isotope methods in recent years. This demonstration has provided the impetus for a reappraisal of the roles of substrate cycling in metabolic regulation and in heat production. These aspects of substrate cycling are discussed in this paper. The relationship between near-equilibrium reactions and substrate cycles is emphasized, since this provides a basis for the derivation of a function describing in precise quantitative terms the factors governing the amplification provided by substrate cycles in metabolic regulation. Some examples of the roles of substrate cycles in providing sensitivity in metabolic regulation are described. The importance of substrate cycling in heat generation in the flight muscle of the bumble-bee and in brown adipose tissue is discussed in detail. 2. We point out that the two possible roles of cycling, heat production and amplification, are intimately linked so that they must be discussed together. It is proposed that variable rates of substrate cycling may be possible so that, for short periods of time. sensitivity can be maximal without excessive heat generation. Variable rates over the long term may be involved in weight control, and the control of such variability in cycling rates may be impaired in obese subjects. Finally, the possibilities that substrate cycles provide explanations for the specific dynamic action of food and for alcoholic and accidental hypothermia are raised.
Detection and tracking in the IBM PeopleVision system (2005)

The detection and tracking of people lie at the heart of many current and near-future applications of computer vision. We describe a background subtraction system designed to detect moving objects in a wide variety of conditions, and a second system to detect objects moving in front of moving backgrounds. Detected foreground regions are tracked with a tracking system which can initiate real-time alarms and generate a smart surveillance index which can be searched to find interesting events in stored video
ChemInform Abstract: Phosphine‐Containing Ligands and the Search for a Tc‐99m Based Myocardial Imaging Agent (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. (1995)

The mechanisms of bee venom immunotherapy (VIT) are largely unknown. The aim of this study was to follow the changes of T cell cytokine secretion during the course of VIT. Ten bee venom-allergic patients with a history of severe systemic reactions, positive skin tests, and bee venom (BV)-specific serum IgE Abs were treated as follows: on the first day, a cumulative dose of 111 micrograms, starting with 0.1 microgram, was administered s.c. under intensive care conditions. Further injections of 100 micrograms BV were given on day 7, day 21, and thereafter at intervals of 4 wk. Blood samples were obtained just before the initiation of VIT, after the last injection on the same day, and before the subsequent BV injections on days 7, 21, and 50 of VIT. Peripheral blood mononuclear cells (PBMC) were stimulated with phospholipase A (PLA), the major BV allergen, or with a control Ag tetanus toxoid (TT). Cytokine secretion was measured 24 h after restimulation of the cultures with solid-phase bound OKT3 F(ab')2 mAbs after 7 days of culture. In PLA-stimulated cultures, VIT resulted in decreased IL-4 and IL-5 and increased IFN-gamma secretion. In TT-stimulated cultures, we observed similar levels of cytokines before and during VIT. We conclude that ultra-rush VIT changes allergen-specific T cell reactivity.
A Quantitative Study of Optical Mapping Surfaces by Atomic Force Microscopy and Restriction Endonuclease Digestion Assays (1998)

Many new techniques in biomolecular chemistry and genomic analysis require the immobilization of molecular reagents on specially prepared surfaces. However, the process of molecular fixation often interferes with or precludes the use of standard in vitro biochemical assays. Optical mapping is an emergent technology for genomic analysis which relies on the biochemical activity of DNA fixed to silanized glass surfaces. Optical mapping surfaces have been shown to be compatible with restriction endonucleases and a variety of DNA polymerases. The essential properties of biochemically active surfaces are poorly understood in most of the current technologies which utilize molecular fixation, including optical mapping. The purpose of this study is to use the powerful technique of atomic force microscopy, in combination with informative enzymatic assays, to correlate biochemical activity with microscopic surface structure. The results presented provide meaningful insight into the effect of surface preparation on the biochemical accessibility of surface-bound molecules. Novel analysis which may facilitate the automation of optical mapping is presented.
Vibrational modes of rare‐earth formates (2009)

Abstract In this work we investigate the room‐temperature Raman spectra of several rare‐earth [RE(HCOO) 3 ; RE = La, Pr, Nd, Gd, Tb and Y] formates. Polarized measurements were carried out for La(HCOO) 3 yielding the observation of most of the Raman‐active phonons predicted by group theory analysis. The respective assignment is given based on the formate vibrations and correlations with previous results in other RE(HCOO) 3 systems. The wavenumber ‘softening’ observed when RE goes from Y to La is accounted for the lattice expansion. Copyright © 2009 John Wiley &amp; Sons, Ltd.
Ring opening metathesis polymerization catalysts (1995)

Abstract Over the past eight years, early transition metal catalysts for the ring opening metathesis polymerization of cyclic olefins have been developed. These catalysts are simple organometallic complexes containing metal carbon multiple bonds that in most cases polymerize olefins by a living process. These catalysts have been used to prepare a family of near monodispersed and structurally homogeneous polymers. A series of group VIII ROMP catalysts that allow a wide range of functionality to be incorporated into the polymer side chains have recently been prepared. This most important members of this family of complexes are the bisphosphinedihaloruthenium carbene complexes. These catalysts show excellent functional group stability and can be used to prepare well defined telechelic polymers, polyolefins with ordered functionality, and highly functionalized block copolymers.
A Review of Green Logistics Schemes Used in Cities Around the World (2005)

Freight carriers strive to provide higher levels of transportation service with lower costs. However, the economic and environmental viability of cities are negatively affected by the present organization of urban goods distribution. Can these two competitive goals be harmonised to create efficient and environmentally friendly urban logistics systems? This paper presents several examples of âgreen logisticsâ schemes tried in a number of forward-looking cities around the world. The review highlights the basic qualitative ideas of these schemes and the results of field tests. Most of the ideas can be applied to other cities, but analysis is needed to figure out which combination of schemes is best for a particular location. This should be an item of some research priority.
Cell-Specific Regulatory Modules Control Expression of Genes in Vascular and Visceral Smooth Muscle Tissues (2002)

A novel approach with chimeric SM22alpha/telokin promoters was used to identify gene regulatory modules that are required for regulating the expression of genes in distinct smooth muscle tissues. Conventional deletion or mutation analysis of promoters does not readily distinguish regulatory elements that are required for basal gene expression from those required for expression in specific smooth muscle tissues. In the present study, the mouse telokin gene was isolated, and a 370-bp (-190 to 180) minimal promoter was identified that directs visceral smooth muscle-specific expression in vivo in transgenic mice. The visceral smooth muscle-specific expression of the telokin promoter transgene is in marked contrast to the reported arterial smooth muscle-specific expression of a 536-bp minimal SM22alpha (-475 to 61) promoter transgene. To begin to identify regulatory elements that are responsible for the distinct tissue-specific expression of these promoters, a chimeric promoter in which a 172-bp SM22alpha gene fragment (-288 to -116) was fused to the minimal telokin promoter was generated and characterized. The -288 to -116 SM22alpha gene fragment significantly increased telokin promoter activity in vascular smooth muscle cells in vitro and in vivo. Conversely, a fragment of the telokin promoter (-94 to -49) increased the activity of the SM22alpha promoter in visceral smooth muscle cells of the bladder. Together, these data demonstrate that both vascular- and visceral smooth muscle-specific regulatory modules direct gene expression in subsets of smooth muscle tissues.