gebhart/patrepeval huggingface dataset:
High-fidelity sensor modeling and self-calibration in vision-aided inertial navigation (2014)

In this paper, we propose a high-precision pose estimation algorithm for systems equipped with low-cost inertial sensors and rolling-shutter cameras. The key characteristic of the proposed method is that it performs online self-calibration of the camera and the IMU, using detailed models for both sensors and for their relative configuration. Specifically, the estimated parameters include the camera intrinsics (focal length, principal point, and lens distortion), the readout time of the rolling-shutter sensor, the IMU's biases, scale factors, axis misalignment, and g-sensitivity, the spatial configuration between the camera and IMU, as well as the time offset between the timestamps of the camera and IMU. An additional contribution of this work is a novel method for processing the measurements of the rolling-shutter camera, which employs an approximate representation of the estimation errors, instead of the state itself. We demonstrate, in both simulation tests and real-world experiments, that the proposed approach is able to accurately calibrate all the considered parameters in real time, and leads to significantly improved estimation precision compared to existing approaches.
Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention and/or Treatment of Alcohol Use Disorders (2012)

Alcohol abuse and dependence have a staggering socioeconomic impact, yet current therapeutic strategies are largely inadequate to treat these disorders. Thus, the development of new strategies that can effectively prevent alcohol use disorders (AUDs) is of paramount importance. Currently approved medications attempt to deter alcohol intake by blocking ethanol metabolism or by targeting the neurochemical systems downstream of the cascades leading to craving and dependence. Unfortunately, these medications have provided only limited success as indicated by the continued high rates of alcohol abuse and alcoholism. The lack of currently available effective treatment strategies is highlighted by the urgent call by the NIAAA to find new and paradigm-changing therapeutics to either prevent or treat alcohol-related problems. This mini-review highlights recent findings from 4 laboratories with a focus on compounds that have the potential to be novel therapeutic agents that can be developed for the prevention and/or treatment of AUDs.
Adaptive ECG interval extraction (2015)

ECG intervals such as QRS, QT and PR provide significant information and are widely used as clinical parameters for diagnosing cardiac diseases. This paper presents a novel QRS detection technique based on Curve Length Transform (CLT) and a refined delineation of P-wave and T-wave using Discrete Wavelet Transform (DWT). The proposed technique was verified using the PhysioNet database. The QRS detection achieved a sensitivity of 98.59% and a positive predictivity of 97.86%. The QRS duration, QT interval and PR interval had a mean error of -1.56± 28.8ms, -5.39± 42.4ms and 0.86± 40.3ms respectively. The proposed algorithm is computationally efficient and is simpler to implement in hardware, hence, will lead to a faster execution time, smaller design area and consequently low power consumption.
Interdigitated Ge p-i-n photodetectors fabricated on a Si substrate using graded SiGe buffer layers (2002)

We report an interdigitated p-i-n photodetector fabricated on a 1-/spl mu/m-thick Ge epitaxial layer grown on a Si substrate using a 10-/spl mu/m-thick graded SiGe buffer layer. A growth rate of 45 /spl Aring//s/spl sim/60 /spl Aring//s was achieved using low-energy plasma enhanced chemical vapor deposition. The Ge epitaxial layer had a threading dislocation density of 10/sup 5/ cm/sup -2/ and a rms surface roughness of 3.28 nm. The 3-dB bandwidth and the external quantum efficiency were measured on a photodetector having 1-/spl mu/m finger width and 2-/spl mu/m spacing with a 25/spl times/28 /spl mu/m/sup 2/ active area. At a wavelength of 1.3 /spl mu/m, the bandwidth was 2.2, 3.5, and 3.8 GHz at bias voltages of -1, -3, and -5 V, respectively. The dark current was 3.2 and 5.0 /spl mu/A at -3 and -5 V, respectively. This photodetector exhibited an external quantum efficiency of 49% at a wavelength of 1.3 /spl mu/m.
Digital photography with flash and no-flash image pairs (2004)

Digital photography has made it possible to quickly and easily take a pair of images of low-light environments: one with flash to capture detail and one without flash to capture ambient illumination. We present a variety of applications that analyze and combine the strengths of such flash/no-flash image pairs. Our applications include denoising and detail transfer (to merge the ambient qualities of the no-flash image with the high-frequency flash detail), white-balancing (to change the color tone of the ambient image), continuous flash (to interactively adjust flash intensity), and red-eye removal (to repair artifacts in the flash image). We demonstrate how these applications can synthesize new images that are of higher quality than either of the originals.
Optical multiplexer for multimode fiber transmission systems (1977)

We have constructed and tested an optical multiplexer for use with multimode optical fibers. The device utilized a blazed plane reflection grating with a single GRIN-rod lens, and was made from commercially available components. The wavelength spacing of the two channels was 27 nm, the insertion losses were ⩽2.4 dB, and the crosstalk was &amp;lt;−30 dB. Optimized versions of the device should be capable of providing at least four channels, with still lower insertion losses, in a rugged stable package 1–2 cm long by 2–4 mm in diameter.
The effect of HER2 expression on cisplatin-based chemotherapy in advanced non-small cell lung cancer patients (2009)

Non-small cell lung cancer patients with high expression of HER2 exhibited resistance to cisplatin-based chemotherapies that are the standard treatment for this disease. Our results indicate that HER2 status may be a predictive and prognostic factor for cisplatin- based therapy response and disease survival.
Stress-Induced Cell Surface Expression and Antigenic Alteration of the Ro/SSA Autoantigen (1995)

Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and conversely anti-Ro52 antibodies are directed only to the denatured protein. It has been known that UV irradiation to cultured keratinocytes induces cell surface expression of Ro/SSA and this phenomenon has been thought to be related with photosensitivity in patients with anti-Ro/SSA antibodies. We studied the quantitative and qualitative changes of the Ro/SSA protein induced by stress, such as with heat shock and UV irradiation, and found that only Ro52 could be expressed on the cell surface of human peripheral lymphocytes by either heat shock or UV irradiation. Moreover, flow cytometric analysis revealed that HS-treated and UV-treated lymphocytes could be stained with patient sera, and by using a technique which combined immunoprecipitation and Western immunoblotting, it has been confirmed that Ro52 expressed on the cell surface can be recognized by anti-Ro/SSA antibodies in native form while cytoplasmic Ro52 cannot be recognized. These data suggest that Ro52 can be antigenic in vivo when expressed on the cell surface and may explain the mechanism of direct tissue damage by anti-Ro/SSA antibodies.
Structure-Based Mutational Analysis of the 4‘-Phosphopantetheinyl Transferases Sfp from Bacillus subtilis:  Carrier Protein Recognition and Reaction Mechanism, (2004)

The activation of apo-peptidyl carrier proteins (PCPs) of nonribosomal peptide synthetases (NRPSs), apo-acyl carrier proteins (ACPs) of polyketide synthases (PKSs), and fatty acid synthases (FASs) to their active holo form is accomplished with dedicated 4'-phosphopantetheinyl transferases (PPTases). They catalyze the transfer of the essential prosthetic group 4'-phosphopantetheine (4'-Ppant) from coenzyme A (CoA) to a highly conserved serine residue in all PCPs and ACPs. PPTases, based on sequence and substrate specifity, have been classified into three types: bacterial holo-acyl carrier protein synthase (AcpS), fatty acid synthase of eukaryotes (FAS2) and Sfp, a PPTase of secondary metabolism. The recently solved crystal structures of AcpS and Sfp-type PPTases with CoA revealed a common alpha + beta-fold with a beta(1)alpha(3)beta(2) motif and similarities in CoA binding and polymerization mode. However, it was not possible to discern neither the PCP binding region of Sfp nor the priming reaction mechanism from the Sfp-CoA cocrystal. In this work, we provide a model for the reaction mechanism based on mutational analysis of Sfp that suggests a reaction mechanism in which the highly conserved E151 deprotonates the hydroxyl group of the invariant serine of PCP. That, in turn, acts as a nucleophile to attack the beta-phosphate of CoA. The Sfp mutants K112, E117, and K120 further revealed that the loop region between beta4 and alpha5 (residues T111-S124) in Sfp is the PCP binding region. Also, residues T44, K75, S89, H90, D107, E109, E151, and K155 that have been shown in the Sfp-CoA cocrystal structure to coordinate CoA are now all confirmed by mutational and biochemical analysis.
Rett syndrome (1994)

Autopsy material from three patients with Rett syndrome and six control cases (frontal, temporal and motor cortical areas) were studied. Pyramidal and non-pyramidal neurones, 100-200 in each specimen, were visualized by Lucifer Yellow microinjection. 3-D reconstructions and rotations were computed using the VoxelView/GT program. Various types of abnormalities in 3-D dendritic architecture of pyramidal neurones in different cortices were observed. Some pyramidal cells in layers II-III had a subnormal number of dendrites. The normally occurring specializations in pyramidal architecture in different cortical areas were absent. Decreased numbers and regional loss ('naked' areas) of dendritic spines were found. Widely distributed cortical afferents were shown by the carbocyanine dye (DiI) tracing method. PAD showed no microdysgenesis, in contrast to the observations in epilepsy.
Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo (2008)

RNA interference (RNAi) provides a promising therapeutic approach to human diseases. However, data from recent reports demonstrate that short-hairpin RNAs (shRNAs) may cause cellular toxicity, and this warrants further investigation of the safety of using RNAi vectors. Earlier, in comparing hairpin-based RNAi vectors, we noted that shRNAs are highly expressed and yield an abundance of unprocessed precursors, whereas artificial microRNAs (miRNAs) are expressed at lower levels and are processed efficiently. We hypothesized that unprocessed shRNAs arise from the saturation of endogenous RNAi machinery, which poses likely a burden to cells. In this study, we tested that hypothesis by assessing the relative effects of shRNAs and artificial miRNAs on the processing and function of miRNAs. In competition assays, shRNAs disrupted miRNA biogenesis and function, whereas artificial miRNAs avoided this interference even when dosed to silence as effectively as shRNAs. We next compared the safety of these vectors in mouse cerebella, and found that shRNAs cause Purkinje cell neurotoxicity. By contrast, artificial miRNA expression was well tolerated, resulting in effective target gene silencing in Purkinje cells. These findings, together with data from earlier work in mouse striata, suggest that miRNA-based platforms are better suited for therapeutic silencing in the mammalian brain.
Multifunctional dendritic cell-targeting polymeric microparticles (2011)

Type 1 diabetes (T1D) is an autoimmune disease characterized by T-cell mediated destruction of insulin-producing β-cells.1 Approximately 13,000 new cases of T1D are diagnosed each year in US childr...
Application of phase separation and mass action models to low aggregation number micelles: a comparative study (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of phase separation and mass action models to low aggregation number micelles: a comparative studyManuel E. Moro and Licesio J. RodriguezCite this: Langmuir 1991, 7, 10, 2017–2020Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/la00058a009https://doi.org/10.1021/la00058a009research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nucleotide sequence of the Bacillus subtilis phoR gene (1988)

The nucleotide sequence of phoR, the positive and negative regulatory gene for alkaline phosphatase and phosphodiesterase formation in Bacillus subtilis, was determined. The sequence data predicted an open reading frame of 1,740 base pairs (579 amino acids) which overlaps the 5 base pairs of the preceding phoP coding sequence. The deduced amino acid sequence was significantly homologous with that of the Escherichia coli phoR gene product, which is the sensory element for the pho regulon.
A Clinical Evaluation of Citrate‐Phosphate‐Dextrose‐Adenine Blood (1975)

(1) Blood was stored in polyvinyl-chloride bags containing citrate-phosphate-dextrose (CPD) with adenine in a final concentration of 0.25 mM. (2) Red cell ATP was well maintained (greater than 70% of original) for 4 weeks in whole blood as well as in red cell concentrate (PCV 85 plus or minus 2%). After 5 weeks the ATP level was about 70% in whole blood and about 40% in red cell concentrate. (3) Red cell 2,3-diphosphoglycerate (DPG) was about 60% of the original after 2 weeks and about 30% after 3 weeks of storage when stored both as whole blood and as red cell concentrate. (4) The red cell 24-hour post-transfusion viability was about 80% after 4 weeks of storage both as whole blood and as red cell concentrate. After 5 weeks of storage the 24-hour viability was 78.7 plus or minus 3.5% in whole blood and 76.5 plus or minus 6.7% in red cell concentrate. (5) 820 patients received 3,238 units of CPD-adenine blood, and 761 patients serving as controls received 2,807 units of acid-citrate-dextrose (ACD) blood. The frequency of transfusion reactions was 3.5% for patients receiving CPD-adenine blood and 4.1% for the control group. (6) The maximum storage time was set at 5 weeks for the CPD-adenine blood and 3 weeks for the ACD blood. The longer preservation time decreased out-dating by at least 50%.
Subepidermal Moisture Predicts Erythema and Stage 1 Pressure Ulcers in Nursing Home Residents: A Pilot Study (2007)

SEM measures are associated with concurrent erythema and PUs and future (1 week later) development of erythema/Stage 1 PUs. SEM may assist in predicting early PU damage, allowing for earlier intervention to prevent skin damage.
A circularly polarized microstrip-fed T-slot antenna (2002)

This paper reports a study of a microstrip-fed T-type slot antenna for circular polarization. Two narrow slots are connected together in the T-type form and this T-slot antenna can be fed by a single microstrip line on the other side of the substrate for circular polarization. Ansoft's Ensemble was used to model the return loss and axial ratio of this T-slot antenna. It is demonstrated that this simple T-type slot antenna with a single microstrip feed line can provide 12 percent bandwidth for 10 dB return loss and 5.5 percent bandwidth for 6 dB axial ratio. Measured results for the return loss agree well with the simulated ones by Ensemble.
No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types (1979)

The question of whether initial treatment is necessary in relatively asymptomatic patients with stage III and IV non-Hodgkin's lymphomas of favorable histologic types was studied by retrospective analysis. Two groups of patients were studied: [1] 44 nonprotocol patients, followed since 1963, in whom initial treatment was withheld until required to evaluate the pace of disease and the necessity of treatment; and [2] 112 previously untreated patients who have participated in prospectively randomized clinical trials since 1971. For all 44 "deferred" patients, the median time before requiring treatment was 31 months, and there have been 19 patients who have not yet required therapy for periods of 3 to 104 months. The median actuarial survival for all 44 patients was 121 months. At 4 years, the actuarial survival of the 44 patients with deferred treatment is 77.3%, compared with 83.2% for the 112 protocol patients (P = 0.60). Careful observation without initiation of therapy is an appropriate option in the management of patients with relatively asymptomatic advanced non-Hodgkin's lymphomas of favorable histologic types.
Interleukin-11 Stimulates Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion in Corticotroph Cells: Evidence for a Redundant Cytokine Network in the Hypothalamo-Pituitary-Adrenal Axis* (1999)

We recently characterized leukemia inhibitory factor (LIF) as an important modulator of hypothalamo-pituitary-adrenal (HPA) axis activity. We now describe the role of interleukin (IL)-11, another member of the IL-6 cytokine family, in the neuro-immuno-endocrine modulation of the HPA axis. In murine hypothalamus, pituitary and corticotroph AtT-20 cells, IL-11 messenger RNA (mRNA) was detectable by RT-PCR only, whereas IL-11R mRNA transcripts were demonstrated by Northern blot. Using RT-PCR, IL-11 and IL-11R gene expression were also detected in normal human pituitaries, as well as in corticotropic and nonfunctioning pituitary adenomas. Incubation of AtT-20 cells for 24 h with 10(-9) M IL-11 stimulated ACTH secretion 1.4 +/- 0.1-fold (P < 0.01), whereas LIF at the same concentration caused a 1.5 +/- 0.1-fold increase (P < 0.001). POMC mRNA expression was induced by IL-11 (0.5 x 10(-9) M) and LIF (0.5 x 10(-9) M) 1.5 +/- 0.18-fold (P < 0.05) and 1.7 +/- 0.13-fold (P < 0.01), respectively. POMC promoter activity, assayed by a -706/+64 rat POMC promoter-luciferase construct, was stimulated by 0.5 x 10(-9) M IL-11 (1.9 +/- 0.06-fold; P < 0.001) and 5 mM Bu2cAMP (7.1 +/- 0.52-fold, P < 0.001), and combined treatment of IL-11 plus Bu2cAMP caused a synergistic 11.7+/-0.71-fold increase ofluciferase activity (P < 0.001 vs. Bu2cAMP alone). Gene expression of SOCS-3, an intracellular inhibitor of cytokine action, peaked as early as 60 min after incubation with IL-11 (0.5 x 10(-9) M) and was induced 3.5-fold. In comparison to mock-transfected AtT-20 cells (AtT-20M), stable overexpression of SOCS-3 (AtT-20S) resulted in significant inhibition of ACTH secretion induced by IL-11 alone (1.5 +/- 0.09 vs. 1.1 +/- 0.04-fold induction, P < 0.01) and IL-11 plus Bu2cAMP (2.1 +/- 0.21 vs. 1.5 +/- 0.06-fold, P < 0.05), but not by Bu2cAMP alone (1.5 +/- 0.12 vs. 1.4 +/- 0.06). In summary, human and murine pituitary express IL-11 and IL-11R transcripts. In murine corticotroph AtT-20 cells, IL- 11 induces POMC gene transcription and ACTH secretion. IL-11 induction of SOCS-3 indicates an intracellular negative feedback control of cytokine-induced POMC expression and ACTH secretion. Thus, IL-11 regulates the HPA axis similarly to LIF, providing further evidence for a redundant cytokine network in the neuro-immuno-endocrine regulation of the HPA axis.
MNEW: Multi-domain Neighborhood Embedding and Weighting for Sparse Point Clouds Segmentation (2020)

Point clouds have been widely adopted in 3D semantic scene understanding. However, point clouds for typical tasks such as 3D shape segmentation or indoor scenario parsing are much denser than outdoor LiDAR sweeps for the application of autonomous driving perception. Due to the spatial property disparity, many successful methods designed for dense point clouds behave depreciated effectiveness on the sparse data. In this paper, we focus on the semantic segmentation task of sparse outdoor point clouds. We propose a new method called MNEW, including multi-domain neighborhood embedding, and attention weighting based on their geometry distance, feature similarity, and neighborhood sparsity. The network architecture inherits PointNet which directly process point clouds to capture pointwise details and global semantics, and is improved by involving multi-scale local neighborhoods in static geometry domain and dynamic feature space. The distance/similarity attention and sparsity-adapted weighting mechanism of MNEW enable its capability for a wide range of data sparsity distribution. With experiments conducted on virtual and real KITTI semantic datasets, MNEW achieves the top performance for sparse point clouds, which is important to the application of LiDAR-based automated driving perception.
Polyphosphazenes Bearing Branched and Linear Oligoethyleneoxy Side Groups as Solid Solvents for Ionic Conduction (1996)

A new series of solid polymer electrolyte materials based on the poly(organophosphazene) system has been designed and synthesized. The new polymers contain linear or branched oligoethyleneoxy side chains. The polymers were characterized by 31P, 13C, and 1H-NMR spectroscopy, gel permeation chromatography, differential scanning calorimetry, and elemental analysis. The ambient temperature (25 °C) ionic conductivities of the polymers complexed with lithium triflate were measured by complex impedance analysis. The polymers that bear linear oligoethyleneoxy side chains [NP{O(CH2CH2O)nCH3}2], have low glass transition temperatures that range from −84 to −75 °C. These polymers have properties that are similar to those of the classical counterpart poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene. They have low dimensional stabilities and undergo viscous flow even at room temperature. The polymers with branched oligoethyleneoxy side chains (podands) have similar glass transition temperatures, in the range of −82 to −79 °C. However, the bulk dimensional stabilities of the branched polymers are significantly higher than those of the corresponding linear side chain series. The branched side chain polymers resist viscous flow and readily form thin, free-standing films. The podand polymers also dissolve lithium triflate to form ionically conducting materials with conductivity levels similar to those of the polymers bearing linear side chains.