gebhart/patrepeval huggingface dataset:
Applications drive secure lightpath creation across heterogeneous domains (2006)

We realize an open, programmable paradigm for application-driven network control by way of a novel network plane - the "service plane" - layered above legacy networks. The service plane bridges domains, establishes trust, and exposes control to credited users/applications while preventing unauthorized access and resource theft. The authentication, authorization, and accounting subsystem and the dynamic resource allocation controller are the two defining building blocks of our service plane. In concert, they act upon an interconnection request or a restoration request according to application requirements, security credentials, and domain-resident policy. We have experimented with such service plane in an optical, large-scale testbed featuring two hubs (NetherLight in Amsterdam, StarLight in Chicago) and attached network clouds, each representing an independent domain. The dynamic interconnection of the heterogeneous domains occurred at Layer 1. The interconnections ultimately resulted in an optical end-to-end path (lightpath) for use by the requesting grid application.
Strategies for Preventing Aspirin-Induced Gastric Bleeding (1986)

Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.
Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals (1993)

The rate of clinical progression is variable among individuals infected with human immunodeficiency virus type 1 (HIV-1). Changes in viral burden which correlate with disease status have been demonstrated in cross-sectional studies; however, a detailed longitudinal study of the temporal relationship between viral burden, CD4+ T-cell numbers, and clinical status throughout the course of infection has not been reported. Multiple longitudinal blood samples were obtained from four HIV-1-infected individuals with clinically divergent profiles. Levels of HIV-1 were measured in sequential samples of peripheral blood mononuclear cells, using both end-point dilution cultures and quantitative polymerase chain reaction methods. Serial HIV-1 isolates from each case were also evaluated to determine their biological properties in vitro. For the three patients with clinical progression, a dramatic increase in the level of HIV-1 was observed concurrent with or prior to a marked drop in CD4+ T lymphocytes. This increase in viral burden was temporally associated with the emergence of a more cytopathic viral phenotype. In contrast, consistently low levels of HIV-1 were observed in the one patient who was clinically and immunologically stable for more than a decade. Moreover, viral isolates from this patient were less cytopathic in vitro compared with HIV-1 isolates from those patients with disease progression. The temporal association between increased viral burden and CD4+ T-cell decline suggests a direct role for HIV-1 in the cytopathology of CD4+ T cells in vivo. Our results indicate that the pathogenic mechanisms responsible for CD4+ T-cell depletion may be related to both quantitative and qualitative changes in HIV-1.
Temporal and spatial patterns of opsin gene expression in zebrafish (Danio rerio) (1995)

In zebrafish, the first class of cone photoreceptor to become morphologically distinct is the ultraviolet-sensitive short single cone, at 4 days postfertilization, whereas the last class, the red- and green-sensitive double cone, becomes distinct at 10 days postfertilization. We have examined the time course of visual pigment gene expression in zebrafish using whole-mount in situ hybridization. Within the retina, opsins may be detected as early as 40 h postfertilization with the ultraviolet and rod visual pigments being expressed before the blue- (48 h) and red- (60 h) sensitive pigments. In the pineal, red-sensitive opsin is expressed at 48 h postfertilization. Visual pigment expression provides a useful tool for investigations of early cell fate in zebrafish.
Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray (2011)

Gene probes upregulated in critically ill pediatric patients with septic shock may allow for the identification of novel candidate serum biomarkers for SSAKI prediction.
Analysis of inducers of theE.coli lacrepressor system mammalian cells and whole animals (1991)

Although the inducible prokaryotic lac repressor system has been successfully adapted for control of gene expression in mammalian cells, little information is available on the pharmacokinetics of beta-galactoside inducers in mammalian cells for optimizing this system. These studies directly measure the cell uptake and clearance in cultured cells and animal tissue cells of lac inducers. In these cells, the beta-galactosides, isopropyl beta-D-thiogalactoside (IPTG) and methyl beta-D-thiogalactoside (MTG), are rapidly taken up, exceeding extracellular levels in less than 2 hours. Greater than 5% of this inducer is found in the nuclear fraction, slightly exceeding the cytoplasmic concentration. Although similar in uptake, IPTG is cleared from the cultured cells significantly faster than MTG. In the mouse, the half-life of both inducers in the blood ranges from 15-30 minutes. HPLC analysis of tissue extracts from inducer-injected mice indicates that the inducer is metabolically stable and functionally able to bind to lac repressor. These results should permit improvement in the adaptation of the lac repressor system to mammalian cells and aid in the development of an adaptable system for gene control in transgenic animals.
Iridium Corroles (2008)

This work reports the synthesis and full characterization of 5,10,15-tris-pentafluorophenylcorrolato-iridium(III) bis-trimethylamine 1 and its octabromo derivative 2. The corrole is planar in both cases (the mean deviation from the plane is as low as 0.0371 A for 1 and 0.0325 A for 2), the UV-vis spectra display a split Soret band with a shoulder attributable to an MLCT transition, and cyclic voltammetry reveals that the iridium(II) oxidation state cannot be accessed, while the oxidation to formal iridium(IV) complexes is achieved at much lower potentials than in other coordination environments.
A low overhead design for testability and test generation technique for core-based systems (2002)

In a fundamental paradigm shift in system design, entire systems are being built on a single chip, using multiple embedded cores. Though the newest system design methodology has several advantages in terms of time-to-market and system cost, testing such core-based systems is difficult due to the problem of justifying test sequences at the inputs of a core embedded deep in the system, and propagating test responses from the core outputs. In this paper, we present a design for testability and symbolic test generation technique for testing such core-based systems on a chip. The proposed method consists of two parts: (i) core-level DFT to make each core testable and transparent, the latter needed to propagate test data through the cores, and (ii) system-level DFT and test generation to ensure the justification and propagation of the precomputed test sequences and test responses of the core. Since the hierarchical testability analysis technique used to tackle the above problem is symbolic, the system test generation method is independent of the bit-width of the cores. The system-level test set is obtained as a by-product of the testability analysis and insertion method without further search. Besides the proposed test method, the two methods that are currently used in the industry were also evaluated on two example systems: (i) FScan-BScan, where each core is full-scanned, and system test is performed using boundary scan, and (ii) FScan-TBus, where each core is full-scanned, and system test is performed using a test bus. The experiments show that the proposed scheme has significantly lower area overhead, delay overhead, and test application time compared to FScan-BScan and FScan-TBus, without any compromise in the system fault coverage.
Resource management for broadband access over time-division multiplexed passive optical networks (2007)

Passive optical networks are a prominent broadband access solution to tackle the "last mile" bottleneck in telecommunications infrastructure. Data transmission over standardized PONs is divided into time slots. Toward the end of PON performance improvement, a critical issue relies on resource management in the upstream transmission from multiple optical network units (ONUs) to the optical line terminal (OLT). This includes resource negotiation between the OLT and the associated ONUs, transmission scheduling, and bandwidth allocation. This article provides an overview of the resource management issues along with the state-of-the-art schemes over time-division multiplexed PONs (TDM-PONs). We categorize the schemes in the literature based on their features, and compare their pros and cons. Moreover, we introduce a unified state space model under which all TDM-PON resource management schemes can be evaluated and analyzed for their system level characteristics. Research directions are also highlighted for future studies.
MEGA-CC: computing core of molecular evolutionary genetics analysis program for automated and iterative data analysis (2012)

http://www.megasoftware.net/.
Saturable absorption in multicore fiber couplers (2013)

The saturable absorption characteristics of two-, three-, and five-core one-dimensional fiber coupler arrays and the seven-core hexagonal fiber coupler array are investigated. It is shown that the performance of all these saturable absorbers is comparable and not much is gained, if anything, by going from a two-core nonlinear coupler geometry to a higher number of cores. This observation is supported by the similarity of the saturable absorption curves, as well as comparable pulse characteristics obtained from the simulation of a generic mode-locked fiber laser cavity.
Multi-Lingual Speaker-Independent Voice User Interface For Mobile Devices (2006)

This paper presents a multi-lingual speaker-independent voice user interface (UI) that has been implemented for Nokia S60 mobile phones. The paper concentrates on discussing the specific approach used for achieving a multi-lingual and configurable speech recognition and speech synthesis system. The main applications are speaker-independent name dialing and voice commands. The novelty of the applications is that the user does not need to train the voice dialing system but the application reads the user's phonebook and generates the required voice tags automatically. The speaker-independent voice dialing has already been introduced in regions where the language diversity is not so great. The system presented in this paper is the first of its kind to support both speech recognition and speech synthesis in more than 40 languages in embedded devices with strict memory and performance requirements
Cloning and expression profiling of testis-expressed piRNA-like RNAs (2007)

Using a novel small RNA cloning method, we identified 630 piRNA-like RNAs (pilRNAs) from the mouse testis, and 498 of them are novel. These pilRNA genes were mapped to all chromosomes as 71 clusters, and the majority of them ( approximately 84%) are derived from intergenic, intronic, and exonic sequences. One of the structural characteristics for pilRNAs is that a single locus can encode numerous homologous pilRNAs with overlapping sequences. Hundreds or even thousands of pilRNAs from a single pilRNA gene cluster are all produced from a single long transcript. Expression profiling for 64 pilRNAs revealed that approximately 14% of all the pilRNAs analyzed displayed a ubiquitous expression pattern, although the majority of ( approximately 86%) pilRNAs were preferentially or exclusively expressed in meiotic and haploid male germ cells of the testis. Our semiquantitative analyses also suggest that the testis is the organ with the highest expression of pilRNAs both in number and in abundance. The large number, high abundance, unique genomic locations, and biogenesis all suggest that pilRNAs have important regulatory roles not only in spermatogenesis but also in other biological processes.
The relationship between force and focal complex development (2002)

To adhere and migrate, cells must be capable of applying cytoskeletal force to the extracellular matrix (ECM) through integrin receptors. However, it is unclear if connections between integrins and the ECM are immediately capable of transducing cytoskeletal contraction into migration force, or whether engagement of force transmission requires maturation of the adhesion. Here, we show that initial integrin-ECM adhesions become capable of exerting migration force with the recruitment of vinculin, a marker for focal complexes, which are precursors of focal adhesions. We are able to induce the development of focal complexes by the application of mechanical force to fibronectin receptors from inside or outside the cell, and we are able to extend focal complex formation to vitronectin receptors by the removal of c-Src. These results indicate that cells use mechanical force as a signal to strengthen initial integrin-ECM adhesions into focal complexes and regulate the amount of migration force applied to individual adhesions at localized regions of the advancing lamella.
Coset-based quasi-cyclic LDPC codes for optimal overlapped message passing decoding (2006)

Due to the regular structures of quasi-cyclic (QC) low-density parity-check (LDPC) codes, the message passing decoding of these codes not only has efficient hardware implementation, but also can be overlapped to improve throughput and hardware utilization efficiency (HUE). In previous work, we proposed a scheduling scheme for the overlapped message passing (OMP) decoding of the SFT codes. In this paper, we first show that our scheduling scheme produces the minimum intra-iteration waiting time for QC LDPC codes. Then we propose a coset-based construction of QC LDPC codes, and study the girth and minimum distance properties of our new codes. Given the same parameters, the ensemble of the SFT codes is a subset of the ensemble of our coset-based QC LDPC codes. Our coset-based QC LDPC codes allow the OMP decoding to achieve greater throughput gain and higher HUE while maintaining the same theoretical performances as the SFT codes.
Expectation of Service Quality in Professional Accounting Firms (1998)

ABSTRACT In Singapore, the Company Act requires every company to have an audit every year regardless of the cost and whether the directors and shareholders want one. As there are many professional accounting firms competing for the audit business of these companies, it has become essential that these accounting firms must strive to ensure that their clients are satisfied with the services provided. This paper reports a survey of 1.96 companies with headquarters in Singapore, Japan, Europe and the United States. The survey revealed the reasons for choosing a particular audit firms and the reasons for staying with them. A modified version of the SERVQUAL scale developed by Parasuraman was used to measure both the expectation and performance of service quality. A gap analysis was also carried out to determine the differences.
Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use (2004)

Although there are reports of cases of acute renal failure occurring in cystic fibrosis (CF) patients, usually in association with the use of nephrotoxic antibiotic therapy, there have been no studies of renal function in this patient group. We hypothesized that long-term use of intravenous (IV) nephrotoxic antibiotics (aminoglycosides and colistin sulphomethate) may contribute to renal disease in CF patients. In a prospective study, we assessed creatinine clearance as an index of renal function with two techniques (24-hr urine collections and the Cockroft-Gault formula) in a group of 80 stable adult CF outpatients chronically infected with Pseudomonas aeruginosa but with no history of preceding renal disease. Using a multiple linear regression model, we evaluated their renal function in terms of their lifetime IV use of aminoglycosides and colistin. Between 31% (Cockroft-Gault formula method) and 42% (24-hr urine collection method) of patients had a creatinine clearance below normal range. Using either method, there was a strong correlation between aminoglycoside use and diminishing renal function (r=- 0.32, P=0.0055), which was potentiated by the coadministration of colistin (r=- 0.42, P <0.0002). However, there was no correlation with colistin when used in combination with other antibiotics alone (r=0.18, P=NS). Repeated IV aminoglycoside use in CF is associated with long-term renal damage. Although this effect is potentiated by colistin, colistin on its own in moderate doses does not appear to be nephrotoxic. IV aminoglycosides should be used cautiously in CF patients, with regular monitoring of renal function.
Preparation of pyrazoles from the C(α)NN-trianion of hydrazones having an α-hydrogen atom (1971)

Certain hydrazones having an α-hydrogen atom were treated with 3 mol. equiv. of n-butyl-lithium to give (presumably) the C(α)NN-trianions. These trianions were aroylated with esters at the α-carbanionic centre and cyclized with acid to give pyrazoles.
Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria (2017)

Diseases caused by antibiotic-resistant bacteria in hospitals are the outcome of complex relationships between several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the human host, and selective forces resulting from interventions such as antibiotic therapy. The emergence and fate of mutations that drive antibiotic resistance are governed by these interactions. In this review, we will examine how different forms of antibiotic resistance modulate bacterial fitness and virulence potential, thus influencing the ability of pathogens to evolve in the context of nosocomial infections. We will focus on 3 important multidrug-resistant pathogens that are notoriously problematic in hospitals: Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. An understanding of how antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the potential to drive novel strategies that can control the development and spread of drug resistance.
Protein Phosphatases 1 and 2A Maintain Endothelial Cells in a Resting State, Limiting the Motility that is Needed for the Morphogenic Process of Angiogenesis (1999)

Angiogenesis that is induced by cancers, including those of the head and neck, requires endothelial cells to shift from a nonmotile resting state to an increased level of motility. Using a human microvascular endothelial cell line, this study shows the importance of the serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A) in restricting endothelial cell motility. Treatment of endothelial cells with increasing concentrations of the PP1 and PP2A inhibitor okadaic acid resulted in cell rounding and increased motility, which was accompanied by cytoskeletal disorganization involving a loss of filamentous beta-tubulin and F-actin. These effects occurred at okadaic acid levels that selectively inhibit PP2A and became more prominent with higher levels that inhibit both PP2A and PP1. This study shows the importance of PP1 and PP2A in maintaining cytoskeletal organization, thereby limiting endothelial cell motility, and suggests that pharmacologic approaches to enhance PP1 and PP2A activities may be useful in preventing key events of the angiogenic process.
Revisiting the Fetal Loss Rate After Second-Trimester Genetic Amniocentesis (2008)

The institutional fetal loss rate attributable to amniocentesis is 0.13%, or 1 in 769 at Washington University School of Medicine. The total fetal loss rate was not significantly different from that observed in patients who had no procedure.
The human sperm protein PH‐20 has hyaluronidase activity (1993)

The PH-20 protein present on the membrane of guinea pig sperm was characterized using a monoclonal antibody [(1991) J. Cell Biol. 111, 2939-2949]. We have isolated the cDNA encoding the human PH-20 protein from a testis library. This cDNA was expressed in RK 13 cells using a vaccinia virus expression system. Cells expressing the human PH-20 protein possess hyaluronidase activity. Treatment with PI-PLC releases the hyaluronidase into the the medium with a concomitant large increase in enzymatic activity. These results demonstrate that the human PH-20 protein has hyaluronidase activity.
Artificial neural network analysis to assess hypernasality in patients treated for oral or oropharyngeal cancer (2011)

Feature analysis of nasalance in oral or oropharyngeal cancer patients is feasible; prediction of subjective parameters varies between moderate and poor.
Unwinding of double-stranded DNA helix by dehydration. (1981)

Conformation changes of the double-stranded DNA helix in response to dehydration were investigated by monitoring, by agarose gel electrophoresis, the linking number of covalently closed circular DNA generated by ligation of linear DNA in the presence of different organic solvents or different temperatures. It was found that: (i) The DNA helix unwinds upon addition of certain organic solvents or elevation of temperature. (ii) The conformational change observed under the experimental conditions is a continuous process in response to the organic solvent concentration. (iii) The delta H of unwinding one linking of the DNA helix is constant at approximately 12.2 +/- 0.4 kcal/mol (1 kcal = 4.184 kJ); the corresponding delta S and d(delta S)/dn are 2nkR and 2kR, in which n is the relative equivalent linking number (referred to the state of delta S = 0 for unwinding) of the DNA, R is the gas constant, and k is equal to 1117/number of base pairs. The delta H, delta S, and d(delta S)/dn for unwinding i linkings are i X 12.2 kcal/mol, 2inkR, and 2ikR, respectively. (iv) d(delta S)/dn, like k, is inversely proportional to the number of base pairs in DNA. (v) Double-stranded DNAs of different chain lengths have average delta S = 35 cal/mol.K for unwinding one linking under the experimental conditions; this corresponds to 127 +/- 14 base pairs per "relative linking."
Excess noise in fiber gyroscope sources (1990)

Excess noise was measured in three potential interferometric fiber gyroscope sources, superluminescent diodes at 0.83 and 1.3 mu m, and a superfluorescent fiber source at 1.06 mu m. All three sources showed limiting signal-to-noise ratios in the 128-132 dB range (1 Hz bandwidth at 100 kHz), in agreement with their measured linewidths. The impact of the excess noise on the fiber gyro random walk coefficient is shown. It is pointed out that the noise source considered is important for interferometric fiber optic gyros because it imposes a limitation that does not arise in optical gyros which use narrowband sources.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Oxidation of Water by MnO‐ 4 Mediated by Thermally Activated Ruthenium Dioxide Hydrate. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.