gebhart/patrepeval huggingface dataset:
Rapid and Selective Inner Ring Deiodination of Thyroxine Sulfate by Rat Liver Deiodinase* (1985)

Previous studies have shown that the inner ring deiodination (IRD) of T3 and the outer ring deiodination (ORD) of 3,3'-diiodothyronine are greatly enhanced by sulfate conjugation. This study was undertaken to evaluate the effect of sulfation on T4 and rT3 deiodination. Iodothyronine sulfate conjugates were chemically synthetized. Deiodination was studied by reaction of rat liver microsomes with unlabeled or outer ring 125I-labeled sulfate conjugate at 37 C and pH 7.2 in the presence of 5 mM dithiothreitol. Products were analyzed by HPLC or after hydrolysis by specific RIAs. T4 sulfate (T4S) was rapidly degraded by IRD to rT3S, with an apparent Km of 0.3 microM and a maximum velocity (Vmax) of 530 pmol/min X mg protein. The Vmax to Km ratio of T4S IRD was increased 200-fold compared with that of T4 IRD. However, formation of T3S by ORD of T4S could not be observed. The rT3S formed was rapidly converted by ORD to 3,3'-T2 sulfate, with an apparent Km of 0.06 microM and a Vmax of 516 pmol/min X mg protein. The enzymic mechanism of the IRD of T4S was the same as that of the deiodination of nonsulfated iodothyronines, as shown by the kinetics of stimulation by dithiothreitol or inhibition by propylthiouracil. The IRD of T4S and the ORD of rT3 were equally affected by a number of competitive inhibitors, suggesting a single enzyme for the deiodination of native and sulfated iodothyronines. In conjunction with previous findings on the deiodination of T3S, these results suggest that sulfation leads to a rapid and irreversible inactivation of thyroid hormone.
Evolving toward effective therapy for acute ischemic stroke (1993)

Acute ischemic stroke is a common, devastating disorder without beneficial therapy. Recent advances concerning the pathophysiology of ischemic brain injury have led to the development of rational pharmacological interventions. Thrombolytic and cytoprotective therapies may be useful and are being evaluated in clinical trials. The design of adequate clinical trials to evaluate these promising therapies has also evolved based on experience. Potential therapy for acute ischemic stroke must be assessed in a large number of patients who are given the intervention within hours of onset using a neurological scoring scale and a disability scale. Several new magnetic resonance imaging technologies are emerging that should allow the clinician to rapidly and accurately identify ischemic brain lesions and to evaluate cerebral perfusion. The availability of potentially efficacious therapies for ischemic stroke evaluated in well-designed clinical trials with magnetic resonance imaging technology, which can also assess therapeutic effects in vivo, should lead to the emergence of therapy to improve the outcome of patients with ischemic stroke in the near future. (<i>JAMA</i>. 1993;270:360-364)
Bit-Interleaved Coded Modulation (2008)

The principle of coding in the signal space follows directly from Shannon’s analysis of waveform Gaussian channels subject to an input constraint. The early design of communication systems focused separately on modulation, namely signal design and detection, and error correcting codes, which deal with errors introduced at the demodulator of the underlying waveform channel. The correct perspective of signal-space coding, although never out of sight of information theorists, was brought back into the focus of coding theorists and system designers by Imai’s and Ungerböck’s pioneering works on coded modulation. More recently, powerful families of binary codes with a good tradeoff between performance and decoding complexity have been (re-)discovered. Bit-Interleaved Coded Modulation (BICM) is a pragmatic approach combining the best out of both worlds: it takes advantage of the signal-space coding perspective, whilst allowing for the use of powerful families of binary codes with virtually any modulation format. BICM avoids the need for the complicated and somewhat less flexible design typical of coded modulation. As a matter of fact, most of today’s systems that achieve high spectral efficiency such as DSL, Wireless LANs, WiMax and evolutions thereof, as well as systems based on low spectral efficiency orthogonal modulation, feature BICM, making BICM the de-facto general coding technique for waveform channels. The theoretical characterization of BICM is at the basis of efficient coding design techniques and also of improved BICM decoders, e.g., those based on the belief propagation iterative algorithm and approximations thereof. In this text, we review the theoretical foundations of BICM under the unified framework of error exponents for mismatched decoding. This framework allows an accurate analysis without any particular assumptions on the length of the interleaver or independence between the multiple bits in a symbol. We further consider the sensitivity of the BICM capacity with respect to the signal-to-noise ratio (SNR), and obtain a wideband regime (or low-SNR regime) characterization. We review efficient tools for the error probability analysis of BICM that go beyond the standard approach of considering infinite interleaving and take into consideration the dependency of the coded bit observations introduced by the modulation. We also present bounds that improve upon the union bound in the region beyond the cutoff rate, and are essential to characterize the performance of modern randomlike codes used in concatenation with BICM. Finally, we turn our attention to BICM with iterative decoding, we review extrinsic information transfer charts, the area theorem and code design via curve fitting. We conclude with an overview of some applications of BICM beyond the classical coherent Gaussian channel.
A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T‐cell leukemia virus type‐I (HTLV‐I) (1985)

We have prepared two new mouse monoclonal antibodies (MAbs) named TARM-34 (IgM) and TAG-34 (IgG1), that react with surface antigens of lines of human lymphocytes bearing a human T-cell leukemia virus type-I (HTLV-I). The characters of these antibodies are compared with those of anti-HTLV-1 gp21 MAb (TA-21, IgG1), anti-HTLV-I p19 MAb (GIN-14, IgG1) and human antibodies from patients with adult T-cell leukemia (ATL). An indirect membrane immunofluorescence assay showed that TARM-34, TAG-34 and TA-21 all reacted specifically with cell-surface antigens of HTLV-I-positive T- and B-cell lines and cultured peripheral blood lymphocytes from HTLV-I-infected adults. Radioimmunoassay showed that serum antibodies from the ATL patients interfered with the binding of TA-21 antibody to cells of the HTLV-I-positive T-cell line MT-2, but not with the bindings of TARM-34 and TAG-34 antibodies. TARM-34 and TAG-34 both precipitated a 34-kd glycoprotein (gP34), while TA-21 precipitated gp21 from a lysate of 3H-glucosamine-labelled MT-2 cells. TARM-34 and TAG-34 also precipitated the 34-kd protein from lysates of MT-2 and HUT 102 cells labelled with 125I- or 35S-cysteine. Interestingly, TARM-34 and TAG-34 also precipitated 35-kd protein from a lysate of other HTLV-I-positive cells (F-Taj cell line) derived from an ATL patient. TA-21 precipitated the 21-kd protein from the lysates of 35S-cysteine-labelled HTLV-IMT-2 virions, but TARM-34 and TAG-34 did not precipitate any protein from this lysate. TARM-34 lysed HTLV-I-bearing cells in the presence of rabbit complement. These results indicate that TARM-34 and TAG-34 both recognize a glycoprotein antigen that is expressed on the surface of HTLV-I-infected cells.
Toxicology of the immune system: a human approach (1993)

Toxicology of the immune system:a human approach , Toxicology of the immune system:a human approach , کتابخانه مرکزی دانشگاه علوم پزشکی تهران
Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing (2012)

Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein function. Functional consequences are only known for some editing sites and the combinatorial effect between multiple sites (functional epistasis) is currently unclear. Similarly, the interplay between RNA editing and splicing, which impacts on post-transcriptional gene regulation, has not been resolved. Here, we describe a versatile antisense approach, which will aid resolving these open questions. We have developed and characterized morpholino oligos targeting the most efficiently edited site--the AMPA receptor GluA2 Q/R site. We show that inhibition of editing closely correlates with intronic editing efficiency, which is linked to splicing efficiency. In addition to providing a versatile tool our data underscore the unique efficiency of a physiologically pivotal editing site.
Irradiation of ultrahigh‐molecular‐weight polyethylene (1985)

Abstract An ultrahigh‐molecular‐weight polyethylene material covering a range of crystallinity from 42 to 79% increased in calorimetric crystallinity as a result of chain scission following ionizing irradiation. Carbonyl was formed by a diffusion‐limited reaction of oxygen with long‐lived free radicals. Trans ‐vinylene production was linear with radiation dose and was highest for the sample of highest crystallinity but was not sensitive to environment.
Immunization with Recombinant Canarypox Vectors Expressing Membrane-Anchored Glycoprotein 120 Followed by Glycoprotein 160 Boosting Fails to Generate Antibodies That Neutralize R5 Primary Isolates of Human Immunodeficiency Virus Type 1 (2000)

Antibodies generated by candidate HIV-1 vaccines in a phase I clinical trial were assessed for neutralizing activity with a panel of eight well-characterized, genetically diverse clade B primary isolates having an R5 phenotype. The vaccines consisted of one of three different recombinant canarypox vectors expressing membrane-anchored HIV-1(MN)gp120 (ALVAC vCP205, vCP1433, and vCP1452) followed by boosting with a soluble gp160 hybrid consisting of MNgp120 and the majority of gp41 from strain IIIB. Serum samples from a subset of volunteers in each arm of the trial, containing moderate to high titers of neutralizing antibodies to HIV-1 MN, were analyzed. Competition assays with peptides revealed that the majority of neutralizing activity was specific for the MN-V3 loop. Despite MN-specific neutralization titers that sometimes exceeded 1:500, no neutralization of primary isolates was detected and, in some cases, mild infection enhancement was observed. In addition, little or no neutralization of the HIV-1 IIIB heterologous T cell line-adapted strain of virus was detected. These results reinforce the notion that monovalent HIV-1 ENV is a poor immunogen for generating cross-reactive neutralizing antibodies.
An Overview of Recent Algorithms for AI Planning. (2001)

During the past several years, AI planning has made major steps forward in terms of the size and difficulty of problems that can be solved. In this article we give an overview of the techniques that have been part of the recent developments. Instead of concentrating on individual planning systems, we review the underlying principles behind many of the successful planners. Most of the overview is devoted to classical planning, that is fully deterministic planning with one initial state, and we discuss more general forms of planning only briefly in the end of the article. 1
`Hass' Avocado Carbohydrate Fluctuations. I. Growth and Phenology (1999)

Seasonal fluctuations in nonstructural carbohydrates (starch and soluble sugars) were studied in `Hass' avocado ( Persea americana Mill.) trees on `Duke 7' rootstock over a 2-year period in southern California. On a dry weight basis, total soluble sugar (TSS) concentrations ranged from 33.0 to 236.0 mg·g -1 dry weight and were high compared to starch concentration (2.0 to 109.0 mg·g -1 dry weight) in all measured organs (stems, leaves, trunks and roots). The seven carbon (C7) sugars, D-mannoheptulose and perseitol, were the dominant soluble sugars detected. The highest starch and TSS concentrations were found in stem tissues, and in stems, a distinct seasonal fluctuation in starch and TSS concentrations was observed. This coincided with vegetative growth flushes over both sampling years. Stem TSS and starch concentrations increased beginning in autumn, with cessation of shoot growth, until midwinter, possibly due to storage of photosynthate produced during the winter photosynthetic period. TSS peaked in midwinter, while starch increased throughout the winter to a maximum level in early spring. A second peak in stem TSS was observed in midsummer following flowering and spring shoot growth. At this time, stem starch concentration also decreased to the lowest level of the year. This complementary cycling between stem TSS and starch suggests that a conversion of starch to sugars occurs to support vegetative growth and flowering, while sugars produced photosynthetically may be allocated directly to support flowering and fruit production.
High efficiency and wideband envelope tracking power amplifier with sweet spot tracking (2010)

This paper describes the implementation of a high efficiency and wideband envelope tracking power amplifier with sweet spot tracking. By modulating supply voltage of power amplifier (PA), efficiency can be increased significantly. And linearity is improved by envelope shaping and sweet spot tracking. The supply modulator has a combined structure of a switching amplifier and a linear amplifier to achieve high efficiency as well as wide bandwidth. The measurement results show efficiencies of 36.4/34.1% for 10/20 MHz long term evolution (LTE) signals with peak to average power ratio (PAPR) of 7.5/7.42 dB.
Palladium(II)‐Catalyzed Sequential Aminopalladation and Oxidative Coupling with Acetylenes/Enones: Synthesis of Newly Substituted Quinolines from 2‐Aminophenyl Propargyl Alcohols (2015)

Abstract Palladium catalyzed conversion of 1‐(2‐aminophenyl)‐propargyl alcohols to 3‐alkynyl quinolines is realized via a cascade that involves aminopalladation, oxidative coupling with alkynes and dehydration. The method is shown to have a broad substrate scope with respect to propargyl alcohols as well as alkynes. Vinyl ketones as coupling partners in the same reaction afforded 3‐alkenyl quinolines with equal ease. magnified image
ActionVLAD: Learning Spatio-Temporal Aggregation for Action Classification (2017)

In this work, we introduce a new video representation for action classification that aggregates local convolutional features across the entire spatio-temporal extent of the video. We do so by integrating state-of-the-art two-stream networks [42] with learnable spatio-temporal feature aggregation [6]. The resulting architecture is end-to-end trainable for whole-video classification. We investigate different strategies for pooling across space and time and combining signals from the different streams. We find that: (i) it is important to pool jointly across space and time, but (ii) appearance and motion streams are best aggregated into their own separate representations. Finally, we show that our representation outperforms the two-stream base architecture by a large margin (13% relative) as well as outperforms other baselines with comparable base architectures on HMDB51, UCF101, and Charades video classification benchmarks.
Pathogenetic Mechanisms of Thrombosis in Malignancy (2001)

The interactions between components of the hemostatic system and cancer cells are multifaceted. Strong clinical evidence is accumulating on the prothrombotic tendency of cancer patients, which is enhanced by anticancer therapy, such as surgery and chemotherapy. The mechanisms of thrombus promotion in malignancy include some general responses of the host to the tumor (acute phase, inflammation, angiogenesis) and specific interactions of tumor cells with the clotting/fibrinolysis systems and with blood (leukocytes, platelets) or vascular cells. It is at present difficult to rank the relative weight of these multiple interactions on the basis of the well-recognized clinical evidence of enhanced thrombotic episodes in tumor patients. In any case, the mechanisms explored so far offer a sound experimental basis for prevention/treatment of thrombosis in tumor patients and leave open the possibility that some antithrombotic strategies may also affect the processes of tumor growth and dissemination.
Information-theoretic metric learning (2007)

In this paper, we present an information-theoretic approach to learning a Mahalanobis distance function. We formulate the problem as that of minimizing the differential relative entropy between two multivariate Gaussians under constraints on the distance function. We express this problem as a particular Bregman optimization problem---that of minimizing the LogDet divergence subject to linear constraints. Our resulting algorithm has several advantages over existing methods. First, our method can handle a wide variety of constraints and can optionally incorporate a prior on the distance function. Second, it is fast and scalable. Unlike most existing methods, no eigenvalue computations or semi-definite programming are required. We also present an online version and derive regret bounds for the resulting algorithm. Finally, we evaluate our method on a recent error reporting system for software called Clarify, in the context of metric learning for nearest neighbor classification, as well as on standard data sets.
The Mathematics of Internet Congestion Control (2005)

Preface Introduction Resource Allocation Congestion Control: A Decentralized Solution Relationship to Current Internet Protocols Linear Analysis with Delay: The Single Link Case Linear Analysis with Delay: The Network Case Global Stability for a Single Link and Single Flow Stochastic Models and Their Deterministic Limits Connection-level Models Real-Time Sources and Distributed Admission Control Conclusions References Index
Using similarity criteria to make negotiation trade-offs (2002)

Addresses the issues involved in software agents making trade-offs during automated negotiations in which they have information uncertainty and resource limitations. In particular the importance of being able to make tradeoffs in real-world applications is highlighted and an algorithm for performing trade-offs for multi-dimensional goods is developed. The algorithm uses the notion of fuzzy similarity in order to find negotiation solutions that are beneficial to both parties. Empirical results indicate the benefits and effectiveness of the trade-off algorithm in a range of negotiation situations.
Trifluoromethyl-substituted pyridyl- and pyrazolylboronic acids and esters: synthesis and Suzuki–Miyaura cross-coupling reactions (2009)

The synthesis of trifluoromethyl-substituted pyridylboronic acids and pyrazolylboronic esters is described via lithiation-boronation protocols (Schemes 1, 3 and 4). A study of their palladium-catalysed cross-couplings with heteroaryl halides is presented. CF3-substituted aryl/heteroaryl-pyridines are thereby obtained (51-98% yields). Analogous cross-couplings have yielded heteroaryl-3-(trifluoromethyl)pyrazoles (60-85% yields); homocoupling of the pyrazolylboronic esters is suppressed by the addition of potassium formate, although competing protodeboronation is observed. Halogenation of the 4-position of selected pyrazole coupling products allows for further cross-couplings to yield tetra-substituted pyrazolyl derivatives (Scheme 5). X-Ray crystal structures are reported for selected pyridylboronic acids, pyrazolylboronic esters and derived trifluoromethyl-substituted heterobiaryl systems. These multi-ring CF3-substituted systems are of interest as building blocks for drug discovery and materials chemistry.
Structure, chromosomal localization, and expression pattern of the murine Magp gene. (1993)

The microfibril-associated glycoprotein (MAGP) was recently established as a discrete constituent of 10-nm microfibrils. We have characterized the primary structure of the mouse transcript, the structure and chromosomal localization of the murine gene, and the developmental pattern of gene expression. The transcript consists of 1,037 base pairs as determined by cDNA cloning, Northern blot analysis, S1 nuclease mapping, and primer extension mapping. Using a cDNA fragment as a probe, we isolated a single genomic clone that contained the entire mouse gene. Analysis of this clone indicated that Magp is fragmented into 9 exons, with the initiator Met codon located in exon 2. As determined by analysis of somatic cell hybrid lines and by fluorescence in situ hybridization, the mouse gene was mapped to chromosome 4 at a location corresponding to region D3-E1. Genomic sequence immediately upstream of the transcription start site was found to be GC-rich but lacked TATA or CCAAT boxes as well as other cis-acting motifs known to regulate transcription. Promoters of this type are usually found in genes that exhibit broad temporal and spatial patterns of expression. Consistent with this idea, the Magp transcript appeared to be the widespread product of mesenchymal/connective tissue cells throughout mouse development. This study presents the first comprehensive evaluation of microfibril gene expression during mammalian development.
Visualizing data with bounded uncertainty (2003)

Visualization is a powerful way to facilitate data analysis, but it is crucial that visualization systems explicitly convey the presence, nature, and degree of uncertainty to users. Otherwise, there is a danger that data will be falsely interpreted, potentially leading to inaccurate conclusions. A common method for denoting uncertainty is to use error bars or similar techniques designed to convey the degree of statistical uncertainty. While uncertainty can often be modeled statistically, a second form of uncertainty, bounded uncertainty, can also arise that has very different properties than statistical uncertainty. Error bars should not be used for bounded uncertainty because they do not convey the correct properties, so a different technique should be used instead. We describe a technique for conveying bounded uncertainty in visualizations and show how it can be applied systematically to common displays of abstract charts and graphs. Interestingly, it is not always possible to show the exact degree of uncertainty, and in some cases it can only be displayed approximately.