gebhart/patrepeval huggingface dataset:
Gesture Recognition with the Leap Motion Controller (2015)

The Leap Motion Controller is a small USB device that tracks hand and finger movements using infrared LEDs, allowing users to input gesture commands into an application in place of a mouse or keyboard. This creates the potential for developing a general gesture recognition system in 3D that can be easily set up by laypersons using a simple, commercially available device. To investigate the effectiveness of the Leap Motion controller for hand gesture recognition, we collected data from over 100 participants and then used this data to train a 3D recognition model based on convolutional neural networks, which can recognize 2D projections of the 3D space. This achieved an accuracy rate of 92.4% on held out data. We also describe preliminary work on incorporating time series gesture data using hidden Markov models, with the goal of detecting arbitrary start and stop points for gestures when continuously recording data.
Human Immunodeficiency Virus Infection of Human-PBL-SCID Mice (1991)

Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and may be useful as a small animal model for acquired immunodeficiency syndrome (AIDS) research. Hu-PBL-SCID mice infected with human immunodeficiency virus-1 (HIV-1) contained virus that was recoverable by culture from the peritoneal cavity, spleen, peripheral blood, and lymph nodes for up to 16 weeks after infection; viral sequences were also detected by in situ hybridization and by amplification with the polymerase chain reaction (PCR). Mice could be infected with multiple strains of HIV-1, including LAV-1/Bru, IIIB, MN, SF2, and SF13. HIV-1 infection affected the concentration of human immunoglobulin and the number of CD4+ T cells in the mice. These results support the use of the hu-PBL-SCID mouse for studies of the pathogenesis and treatment of AIDS.
A Surprise from 1954: Siloxane Equilibration Is a Simple, Robust, and Obvious Polymer Self-Healing Mechanism (2012)

Tetramethylammonium silanolate-initiated ring-opening copolymerization of octamethylcyclotetrasiloxane (D(4)) and bis(heptamethylcyclotetrasiloxanyl)ethane (bis-D(4)) renders cross-linked network polymers that contain ethylene bridges and active silanolate end groups. These "living" reactive anionic species are not neutralized by ambient atmosphere exposure (are stable to water, oxygen, CO(2)) and promote thermally activated equilibration among different network isomers and cyclic oligomers. The cross-link density of these living networks can be controlled by the ratio of D(4):bis-D(4), and the density of active chain ends is determined from the initiator:monomer ratio. We report that samples prepared with particular ratios of initiator:D(4):bis-D(4) can be cut with a sharp knife, even into two pieces, and can heal by siloxane equilibration to restore the original strength of the silicone sample. Fracture toughness measurements were carried out and revealed complete (mechanical) healing. Broken and healed samples generally failed in locations other than the initially cracked region. We call attention to publications and patents from the 1950s that suggest that this self-healing behavior was likely obvious 60 years ago.
Hydrogen Separation Membranes for Vision 21 Fossil Fuel Plants (2001)

Eltron Research and team members CoorsTek, McDermott Technology, Sued Chemie, Argonne National Laboratory, and Oak Ridge National Laboratory are developing an environmentally benign, inexpensive, and efficient method for separating hydrogen from gas mixtures produced during industrial processes, such as coal gasification. This objective is being pursued using dense membranes based in part on Eltron-patented ceramic materials with a demonstrated ability for proton and electron conduction. The technical goals are being addressed by modifying single-phase and composite membrane composition and microstructure to maximize proton and electron conductivity without loss of material stability. Ultimately, these materials must enable hydrogen separation at practical rates under ambient and high-pressure conditions, without deactivation in the presence of feedstream components such as carbon dioxide, water, and sulfur. This project was motivated by the Department of Energy (DOE) National Energy Technology Laboratory (NETL) Vision 21 initiative which seeks to economically eliminate environmental concerns associated with the use of fossil fuels. The proposed technology addresses the DOE Vision 21 initiative in two ways. First, this process offers a relatively inexpensive solution for pure hydrogen separation that can be easily incorporated into Vision 21 fossil fuel plants. Second, this process could reduce the cost of hydrogen, which is a clean burning fuel under increasing demand as supporting technologies are developed for hydrogen utilization and storage. Additional motivation for this project arises from the potential of this technology for other applications. By appropriately changing the catalysts coupled with the membrane, essentially the same system can be used to facilitate alkane dehydrogenation and coupling, aromatics processing, and hydrogen sulfide decomposition.
New Compounds. Derivatives of 2,5-Diaminobenzenesulfonamide (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Compounds. Derivatives of 2,5-DiaminobenzenesulfonamideA GoldfarbCite this: J. Am. Chem. Soc. 1943, 65, 4, 738–739Publication Date (Print):April 1, 1943Publication History Published online1 May 2002Published inissue 1 April 1943https://pubs.acs.org/doi/10.1021/ja01244a061https://doi.org/10.1021/ja01244a061research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Turbomolecular pump vacuum system for the Princeton Large Torus (1978)

A turbomolecular pump vacuum system has been designed and installed on the Princeton Large Torus (PLT). Four vertical shaft, oil-bearing, 1500-l/s turbomolecular pumps have been interfaced to the 6400-l PLT vacuum vessel to provide a net pumping speed of 3000 l/s for H2. The particular requirements and problems of tokamak vacuum systems are enumerated. A vacuum control system is described which protects the vacuum vessel from contamination and protects the turbomolecular pumps from damage under a variety of possible failure modes. The performance of the vacuum system is presented in terms of pumping speed mesurements and residual gas behavior.
Crystallization in a Mixture of Solvents by Using a Crystal Modifier: Morphology Control in the Synthesis of Highly Monodisperse CaCO3 Microspheres (2006)

It's under control: In the presence of an artificial double-hydrophilic block copolymer, poly(ethylene glycol)-b-poly(L-glutamic acid), highly monodisperse vaterite microspheres crystallize from a mixture of N,N-dimethylformamide and water (see picture). Varying the ratio of the solvents can control the morphology of the CaCO3 crystals. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600029_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Operation of universal gates in a solid-state quantum computer based on clean Josephson junctions betweend-wave superconductors (2000)

The operation of a solid-state superconducting quantum computer based on clean Josephson junctions between two d-wave superconductors is considered. We show that freezing of passive qubits can be achieved using a dynamic global refocusing technique. Further, we demonstrate that a universal set of gates can be realized on this system, thereby proving its universality.
Normal and neoplastic plasma cell membrane phenotype: studies with new monoclonal antibodies. (1987)

Three monoclonal antibodies (MoAb), named 8A, 8F6 and 62B1, reacting with plasma cell-associated antigens, were characterized. 8A was found to be positive throughout the B cell lineage maturation steps from the immature B-committed CD10+ cell to the plasma cells. 8F6 and 62B1 reactivity is restricted to more mature cells and related lymphoid malignancies. In particular 62B1 appears to be limited to hairy cells and plasma cells. The results show that it is possible to obtain reagents reacting with plasma cells by immunizing mice with cells derived from human multiple myelomas. Furthermore, the obtained results suggest that it is possible to elicit antibodies against antigens which are present throughout all the differentiation steps of the B cell lineage. These new MoAb could help in elucidating the phenotype of the plasma cells and the relationships of multiple myelomas with other B cell proliferative disorders.
Cytomegalovirus as a hepatotropic virus. (2002)

Hepatitis is a frequent complication of cytomegalovirus infection in the immunocompetent as well as the immunocompromised host. Current knowledge of liver involvement in different groups of subjects undergoing cytomegalovirus infection, such as congenitally infected newborns, immunocompetent adults, transplant recipients and AIDS patients, will be summarized in this chapter. Furthermore, a recently identified population at risk for cytomegalovirus infection, hepatopathic patients, will be described.
The Apolipoprotein E-mimetic Peptide COG112 Inhibits the Inflammatory Response to Citrobacter rodentium in Colonic Epithelial Cells by Preventing NF-κB Activation (2008)

Inflammatory bowel disease arises from the interplay between luminal bacteria and the colonic mucosa. Targeted inhibition of pro-inflammatory pathways without global immunosuppression is highly desirable. Apolipoprotein (apo) E has immunomodulatory effects and synthetically derived apoE-mimetic peptides are beneficial in models of sepsis and neuroinflammation. Citrobacter rodentium is the rodent equivalent of enteropathogenic Escherichia coli, and it causes colitis in mice by colonizing the surface of colonic epithelial cells and inducing signaling events. We have reported that mice deficient in inducible nitric-oxide (NO) synthase (iNOS) have attenuated C. rodentium-induced colitis. We used young adult mouse colon (YAMC) cells that mimic primary colonic epithelial cells to study effects of an antennapedia-linked apoE-mimetic peptide, COG112, on C. rodentium-activated cells. COG112 significantly attenuated induction of NO production, and iNOS mRNA and protein expression, in a concentration-dependent manner. COG112 inhibited the C. rodentium-stimulated induction of iNOS and the CXC chemokines KC and MIP-2 to the same degree as the NF-kappaB inhibitors MG132 or BAY 11-7082, and there was no additive effect when COG112 and these inhibitors were combined. COG112 significantly reduced nuclear translocation of NF-kappaB, when assessed by electromobility shift assay, immunoblotting, and immunofluorescence for p65. This correlated with inhibition of both C. rodentium-stimulated IkappaB-alpha phosphorylation and degradation, and IkappaB kinase activity, which occurred by inhibition of IkappaB kinase complex formation rather than by a direct effect on the enzyme itself. These studies indicate that apoE-mimetic peptides may have novel therapeutic potential by inhibiting NF-kappaB-driven proinflammatory epithelial responses to pathogenic colonic bacteria.
Renal Angiotensin-Converting Enzyme Is Essential for the Hypertension Induced by Nitric Oxide Synthesis Inhibition (2014)

The kidney is an important source of angiotensin-converting enzyme (ACE) in many species, including humans. However, the specific effects of local ACE on renal function and, by extension, BP control are not completely understood. We previously showed that mice lacking renal ACE, are resistant to the hypertension induced by angiotensin II infusion. Here, we examined the responses of these mice to the low-systemic angiotensin II hypertensive model of nitric oxide synthesis inhibition with L-NAME. In contrast to wild-type mice, mice without renal ACE did not develop hypertension, had lower renal angiotensin II levels, and enhanced natriuresis in response to L-NAME. During L-NAME treatment, the absence of renal ACE was associated with blunted GFR responses; greater reductions in abundance of proximal tubule Na(+)/H(+) exchanger 3, Na(+)/Pi co-transporter 2, phosphorylated Na(+)/K(+)/Cl(-) cotransporter, and phosphorylated Na(+)/Cl(-) cotransporter; and greater reductions in abundance and processing of the γ isoform of the epithelial Na(+) channel. In summary, the presence of ACE in renal tissue facilitates angiotensin II accumulation, GFR reductions, and changes in the expression levels and post-translational modification of sodium transporters that are obligatory for sodium retention and hypertension in response to nitric oxide synthesis inhibition.
Comparative quantification and identification of phosphoproteins using stable isotope labeling and liquid chromatography/mass spectrometry (2000)

A new liquid chromatography/mass spectrometry (LC/MS) method is described for relative quantification of phosphoproteins to simultaneously compare the phosphorylation status of proteins under two different conditions. Quantification was achieved by beta-elimination of phosphate from phospho-Ser/Thr followed by Micheal addition of ethanethiol and/or ethane-d(5)-thiol selectively at the vinyl moiety of dehydroalanine and dehydroamino-2-butyric acid. The method was evaluated using the model phosphoprotein alpha(S1)-casein, for which three phosphopeptides were found after tryptic digestion. Reproducibility of the relative quantification of seven independent replicates was found to be 11% SD. The dynamic range covered two orders of magnitude, and quantification was linear for mixtures of 0 to 100% alpha(S1)-casein and dephospho-alpha(S1)-casein (R(2) = 0.986). Additionally, the method allowed protein identification and determination of the phosphorylation sites via MS/MS fragmentation.
Volume determinations using computed tomography (1982)

Computed tomography potentially offers the most accurate noninvasive means of estimating in vivo volumes. Contiguous 1-cm-thick CT scans were obtained through phantoms, dog kidneys in vivo, and human spleens before splenectomy. Cross-sectional areas were calculated for each individual scan and volumes then determined with each of four mathematical integration techniques. Volume estimations were compared to volumes determined by water displacement. The simplest, most practical means of calculating volumes, using the summation-of-areas technique with scans obtained at 2 cm intervals, was similar in accuracy to more complex methods. The mean percentage error of volume calculations using the sum-of-areas technique was 4.95% for five immobile phantoms, 3.86% for eight dog kidneys, 3.59% for eight human spleens in vivo at 1 cm scan spacing, and 3.65% for the same human spleens at 2 cm scan spacings. Difficulties in visual recognition and manual tracking of object boundaries seem to be more significant sources of error than patient-related factors.
Early sacral neuromodulation prevents urinary incontinence after complete spinal cord injury (2009)

Future SCI investigations will be conducted to evaluate the potential benefits of even earlier SNM placement to progressively enhance pelvic organ functionality. This new approach may provide important clues required for assessing whether neuronal information is passed through the sympathetic trunk ganglion to the brain after complete SCI. Further investigations are needed to determine if functional magnetic resonance imaging (fMRI) might be helpful for analyzing changes in brain function in patients with SNMs and those taking antimuscarinics.
Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation (1997)

Interleukin (IL)-12 is a monocyte- and macrophage-derived cytokine that plays a crucial role in both the innate and the acquired immune response. In this study, we examined the effects that ligating specific macrophage receptors had on the induction of IL-12 by lipopolysaccharide (LPS). We report that ligation of the macrophage Fcγ, complement, or scavenger receptors inhibited the induction of IL-12 by LPS. Both mRNA synthesis and protein secretion were diminished to near-undetectable levels following receptor ligation. Suppression was specific to IL-12 since IL-10 and tumor necrosis factor-α (TNF-α) production were not inhibited by ligating macrophage receptors. The results of several different experimental approaches suggest that IL-12 downregulation was due to extracellular calcium influxes that resulted from receptor ligation. First, preventing extracellular calcium influxes, by performing the assays in EGTA, abrogated FcγR-mediated IL-12(p40) mRNA suppression. Second, exposure of macrophages to the calcium ionophores, ionomycin or A23187, mimicked receptor ligation and inhibited IL-12(p40) mRNA induction by LPS. Finally, bone marrow–derived macrophages from FcR γ chain–deficient mice, which fail to flux calcium after receptor ligation, failed to inhibit IL-12(p40) mRNA induction. These results indicate that the calcium influxes that occur as a result of receptor ligation are responsible for inhibiting the induction of IL-12 by LPS. Hence, the ligation of phagocytic receptors on macrophages can lead to a dramatic decrease in IL-12 induction. This downregulation may be a way of limiting proinflammatory responses of macrophages to extracellular pathogens, or suppressing the development of cell-mediated immunity to intracellular pathogens.
An exercise in test generation for telecommunications services (2002)

This presentation addresses the problem of specifying tests to check the correct working of a service implementation. The correct working should cover testing the correct functional behaviour with respect to the user's perception, service management aspects, performance, billing aspects and interworking with other services and network elements. We performed an experiment to use existing test generation tools (designed for protocol testing) for service test generation. The results are promising in that the generated tests compare well to tests designed by service experts, while taking less time to develop and easier to maintain.
High-k gate dielectrics with ultra-low leakage current based on praseodymium oxide (2002)

We show that crystalline praseodymium oxide films of the Pr/sub 2/O/sub 3/-type grown on Si(100) have outstanding dielectric properties, displaying a dielectric constant of 31 independent of substrate doping, ultra-low leakage current density of 5/spl times/10/sup -9/ A/cm/sup 2/ at V/sub g/=/spl plusmn/1.0 V @ EOT=14 /spl Aring/, good reliability, and reversible electrical breakdown. Thin Pr/sub 2/O/sub 3/ layers survive anneals of up to 1000/spl deg/C for 15 seconds with no degradation in electrical properties.
Vector-mediated cancer gene therapy: An overview (2005)

In recent years there has been a dramatic increase in developing gene therapy approaches for the treatment of cancer. The two events that have permitted the formulation of concept of cancer gene therapy are the new understanding of the molecular mechanisms underlying oncogenesis, and the development of the DNA-delivery vehicles or vectors. Many approaches to cancer gene therapy have been proposed, and several viral and non-viral vectors have been utilized. The purpose of this review article is to describe the various strategies of cancer gene therapy (transfer of tumor suppressor genes, suicide genes-enzyme/pro-drug approach, inhibition of dominant oncogenes, immunomodulation approaches, expression of molecules that affect angiogenesis, tumor invasion and metastasis, chemosensitization and radiosensitization approaches, and chemoprotection of stem cells). The chapter also reviews the commonly used vectors (retroviral vectors, adenoviral vectors, adeno-associated viral vectors, pox viruses, herpes simplex viruses, HIV- vectors, non-viral vectors and targetable vectors) for cancer gene therapy. Some of the important issues in cancer gene therapy, and the potential future directions are also being discussed.
Improved Encapsulation of DNA in pH-Sensitive Liposomes for Transfection (1992)

A simple method has been developed to prepare liposomes containing large amounts of DNA. The procedure consisted of three cycles of freeze-thawing a mixture of sonicated liposomes and DNA. The encapsulation efficiency depended on the size of DNA. For a small plasmid (2.7 kb), approximately 40% of input DNA was entrapped with an efficiency of 16 μgDNA/μmol lipid. For larger plasmids, the encapsulation efficiency decreased considerably. Transfection of cultured mouse L929 cells mediated by the DNA-containing liposomes was assayed with a plasmid containing the E. coli chloramphenicol acetyl transferase gene. The transfection activity of the liposome was primarily determined by its pH sensitivity. Acid-sensitive liposomes transfected cells efficiently, whereas pH-insensitive liposomes were much less active. The level of the expression of the exogenous gene in the treated cells could be further modulated by protein kinase C (PKC) activators that were incorporated into the liposomal membrane as a minor lipid component. Transfection conditions were optimized with respect to DNA, lipid, and PKC activator concentrations. The results of the current study may help the use of liposomal delivery system for applications in gene therapy.
A survey and tutorial on contemporary aspects of multiple-valued logic and its application to microelectronic circuits (2016)

Multiple-valued logic has a history that goes back to the 1920s. Its flagship symposium was established in 1971. Despite multiple-valued logic's long history, there have been many recent advances, with several important contributions to microelectronic circuits and systems. This tutorial introduction to the area of multiple-valued logic and survey of recent advances focuses on those contemporary aspects of the field that are most relevant to the circuits and systems community.