gebhart/patrepeval huggingface dataset:
Quantitative optical image reconstruction of turbid media by use of direct-current measurements (2000)

We present a detailed experimental study concerning quantitative optical property reconstruction of heterogeneous turbid media by use of absolute dc data only. We performed experiments by using tissuelike phantoms in both single-target and multitarget configurations in which variations in target size and optical contrast with the background were explored. Our results show that both scattering and absorption images can be reconstructed quantitatively by use of dc data only, whereas it was impossible to obtain such quantitative information in previously reported studies. We believe that this improvement is primarily a result of the realization of a novel data preprocessing/optimization scheme for accurately determining several critical parameters needed for reconstruction. The use of this data preprocessing/optimization scheme also eliminates the calibration reference measurement previously required for reconstruction. Experimental confirmation of this scheme is given in detail.
Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. (1990)

Of 26 Ashkenazi Jewish patients with pemphigus vulgaris, 24 (92.3%) carried the major histocompatibility complex (MHC) class II alleles HLA-DR4, DQw3, of which all were of the subtype DR4, DQw8. From studies of the patients and their families, haplotypes were defined. It was found that, of the patients who carried HLA-DR4, DQw8, 75% carried one or the other (and in one case, both) of two haplotypes [HLA-B38, SC21, DR4] or HLA-B35, SC31, DR4. The former is a known extended haplotype among normal Jews, with a frequency of 0.102, and the latter may also be an extended haplotype in this ethnic group, with a frequency of 0.017 among normal haplotypes from Jews. Of the remaining DR4-positive patients, all but one had a presumed D-region segment (defined as SC21, DR4, DQw8 or SC31, DR4, DQw8 with variable HLA-B) of these haplotypes. Only one patient had DR4, DQw8 without any other markers of the extended haplotypes. The number of homozygotes and heterozygotes for DR4, DQw8 was consistent with dominant but not recessive (P less than 0.01) inheritance of a class II or a class II-linked susceptibility gene for the disease. Since the disease is entirely attributable to the presence of an antibody to an intraepidermal intercellular cement substance, it is likely that the class II susceptibility gene (on [HLA-B38, SC21, DR4, DQw8], HLA-B35, SC31, DR4, DQw8, or their segments, in Jewish patients) controls the production of the antibody as a dominantly expressed immune response gene.
Conditional purchase orders (1997)

Article Free Access Share on Conditional purchase orders Authors: John Kelsey Counterpane Systems, 101 East Minnehaha Parkway, Minneapolis, MN Counterpane Systems, 101 East Minnehaha Parkway, Minneapolis, MNView Profile , Bruce Schneier Counterpane Systems, 101 East Minnehaha Parkway, Minneapolis, MN Counterpane Systems, 101 East Minnehaha Parkway, Minneapolis, MNView Profile Authors Info & Claims CCS '97: Proceedings of the 4th ACM conference on Computer and communications securityApril 1997Pages 117–124https://doi.org/10.1145/266420.266446Published:01 April 1997Publication History 2citation1,237DownloadsMetricsTotal Citations2Total Downloads1,237Last 12 Months523Last 6 weeks68 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Improving Goldschmidt division, square root, and square root reciprocal (2000)

The aim of this paper is to accelerate division, square root, and square root reciprocal computations when the Goldschmidt method is used on a pipelined multiplier. This is done by replacing the last iteration by the addition of a correcting term that can be looked up during the early iterations. We describe several variants of the Goldschmidt algorithm, assuming 4-cycle pipelined multiplier, and discuss obtained number of cycles and error achieved. Extensions to other than 4-cycle multipliers are given. If we call G/sub m/ the Goldschmidt algorithm with m iterations, our variants allow us to reach an accuracy that is between that of G/sub 3/ and that of G/sub 4/, with a number of cycle equal to that of G/sub 3/.
GPU Rendering of Relief Mapped Conical Frusta (2009)

Abstract This paper proposes to use relief‐mapped conical frusta (cones cut by planes) to skin skeletal objects. Based on this representation, current programmable graphics hardware can perform the rendering with only minimal communication between the CPU and GPU. A consistent definition of conical frusta including texture parametrization and a continuous surface normal is provided. Rendering is performed by analytical ray casting of the relief‐mapped frusta directly on the GPU. We demonstrate both static and animated objects rendered using our technique and compare to polygonal renderings of similar quality.
Mucosal Treatments for Herpes Simplex Virus: Insights on Targeted Immunoprophylaxis and Therapy (2009)

Herpes simplex virus (HSV) serotypes 1 and 2 establish lifelong infections that can produce reactivated pools of virus at mucosal sites where primary infections were initiated. No approved vaccines are available. To break the transmission cycle, interventions must either prevent infection or reduce infectivity at mucosal sites. This article discusses the recent experimental successes of immunoprophylactic and therapeutic compounds that enhance resistance and/or reduce viral loads at genital and ocular mucosa. Current data indicate Toll-like receptor agonists and selected immunomodulating compounds effectively increase the HSV infection threshold and hold promise for genital prophylaxis. Similarly, immunization at genital and extragenital mucosal sites is discussed. Finally, preclinical success with novel immunotherapies for ocular HSV that address herpetic keratitis and corneal blindness is reviewed.
LATE ONSET, FATAL GRAFT VS. HOST DISEASE IN A LIVER TRANSPLANT RECIPIENT (2004)

A178 Case Report: A 52 year old Hispanic male received a liver transplant for end stage liver disease due to alcoholic cirrhosis. His post transplant course was unremarkable until about eight months after transplant when he presented with severe neutropenia, infections and diarrhea. He was diagnosed to have several infections secondary to bone marrow aplasia. The possible differential diagnosis of graft vs. host disease (GvHD) was not initially considered because that had not been reported to occur so long after transplant. However, he did not respond to therapy and subsequent testing of his peripheral blood and bone marrow revealed that graft vs. host disease was certainly the cause of his aplasia. Using PCR analysis of 11 Single Tandem Repeat (STR) locus alleles present in stored samples collected from the patient and donor prior to transplant, the patient’s then current peripheral blood mononuclear cells were (only) approximately 4% of recipient origin. His bone marrow sample could not be separated into cell fractions because it was so acellular but the total nucleated cell population was 30% of donor origin. The high proportion of recipient cells in the bone marrow sample could reflect the inclusion of non-hematopoietic cells in the sample tested. The patient was treated with OKT3 to try to eliminate the donor lymphocytes and was quickly scheduled to receive a stem cell transplant from an HLA identical brother but he succumbed to his overwhelming fungemia. Comments: This patient did not have any of the risk factors for GvHD that have previously been described. He was relatively young and shared only a single major HLA antigen with his liver donor: HLA-B35. He was mismatched not only for both HLA-A types but also for one HLA-B type, one HLA-C type, both DRB1 types, DR52 (vs. the patient’s DR53) and one DQ type. This case should serve to remind clinicians to consider the possibility of GvHD for any post-transplant patient who presents with aplasia at any time after transplant. The long-term survival of donor stem cells has been well documented in many solid organ transplant recipients, and the factors that can initiate a GvHD response are certainly not well known. A more timely allogeneic stem cell transplant could then be considered. Storage of patient and donor samples collected at the time of transplant to facilitate making this diagnosis post transplant is highly recommended.
Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer (2010)

Abstract Purpose: Some 85% of lung cancers are smoking related. Here, we investigate the role of serine protease HtrA3 in smoking-related lung cancer. Experimental Design: We assess HtrA3 methylation and its corresponding expression in the human bronchial cell line BEAS-2B following cigarette smoke carcinogen treatment, in lung cancer cell lines and in primary lung tumors from light, moderate, and heavy smokers. We also show the effects of HtrA3 downregulation on MTT reduction and clonogenic survival with etoposide and cisplatin treatment and the corresponding effects of HtrA3 re-expression during treatment. Results: We show for the first time that HtrA3 expression is reduced or completely lost in over 50% of lung cancer cell lines and primary lung tumors from heavy smokers. Treatment of HtrA3-deficient cell lines with 5-aza-2′-deoxycytidine resulted in a dose-dependent increase in HtrA3 transcription. Further, sequence analysis of bisulfite-modified DNA from lung cancer cell lines and from primary lung tumors showed an increased frequency of methylation within the first exon of HtrA3 with a corresponding loss of HtrA3 expression, particularly in tumors from smokers. In BEAS-2B, treatment with the cigarette smoke carcinogen 4-(methylnitrosamino)-I-(3-pyridyl)-1-butanone resulted in HtrA3 downregulation with a corresponding increase in methylation. Additional studies indicate resistance to etoposide and cisplatin cytotoxicity as a functional consequence of HtrA3 loss. Finally, immunohistochemical analysis of primary lung tumors revealed a strong correlation between low HtrA3 expression and heavy smoking history. Conclusions: Collectively, these results suggest that cigarette smoke–induced methylation of HtrA3 could contribute to the etiology of chemoresistant disease in smoking-related lung cancer. Clin Cancer Res; 16(2); 398–409
Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis (2014)

Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. Recently, A20 was identified as a key negative regulator for T cell activation and inflammatory signaling and may be involved in RA pathogenesis. In this study, we analyzed the expression level of A20, NF-κB, and A20 regulatory factor mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) in patients with RA. Real-time PCR was used to determine the expression level of MALT1, MALT-V1, A20, and NF-κB genes in RA and healthy individuals (HI). Significantly lower A20 expression was found in RA patients compared with those in the healthy group, while NF-κB overexpression could be detected in patients with RA. Moreover, the MALT1 and MALT1-V1 expression level was downregulated in RA patients. A positive correlation between MALT1 and A20 and MALT1-V1 and A20 was found in patients with RA, and a tendency towards a negative correlation was found between MALT1 and NF-κB, MALT1-V1 and NF-κB, and A20 and NF-κB. In conclusion, we first characterized the alternative expression pattern of MALT1, A20, and NF-κB in RA, which may be related to abnormal T cell activation.
The synthesis of robust polynomial arithmetic with stochastic logic (2008)

As integrated circuit technology plumbs ever greater depths in the scaling of feature sizes, maintaining the paradigm of deterministic Boolean computation is increasingly challenging. Indeed, mounting concerns over noise and uncertainty in signal values motivate a new approach: the design of stochastic logic, that is to say, digital circuitry that processes signals probabilistically, and so can cope with errors and uncertainty. In this paper, we present a general methodology for synthesizing stochastic logic for the computation of polynomial arithmetic functions, a category that is important for applications such as digital signal processing. The method is based on converting polynomials into a particular mathematical form --- Bernstein polynomials --- and then implementing the computation with stochastic logic. The resulting logic processes serial or parallel streams that are random at the bit level. In the aggregate, the computation becomes accurate, since the results depend only on the precision of the statistics. Experiments show that our method produces circuits that are highly tolerant of errors in the input stream, while the area-delay product of the circuit is comparable to that of deterministic implementations.
Hierarchic shape description via singularity and multiscaling (2002)

We introduce a new concept of ridges, ravines and related structures (skeletons) associated with surfaces in three-dimensional space that generalizes the medial axis transformation approach. The concept is based on singularity theory and involves both local and global geometric properties of the surface; it is invariant with respect to translations and rotations of the surface. It leads to a method of hierarchic description of surfaces that yields new approaches to shape coding, rendering and design. The extraction of the features is based on differential geometry of surfaces with consequent segregation via multiscale analysis. Terrain feature recognition, dental shape reconstruction and medical imagery are a partial list of applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The management of herpes simplex virus infections (2002)

Herpes simplex virus persists in a latent form for the life of its host, periodically reactivating and often resulting in significant psychosocial distress for the patient. Currently no cure is available. Antiviral therapy is the main treatment modality, used either orally, intravenously, or topically to prohibit further replication of the virus and thereby minimize cellular destruction. However, immunologic advances in the treatment and prevention of herpes simplex infections are promising and continue to be studied.
Cancer and Radiation Therapy: Current Advances and Future Directions (2012)

In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. However with its increasing incidence, the clinical management of cancer continues to be a challenge for the 21st century. Treatment modalities comprise of radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. Radiation therapy remains an important component of cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during their course of illness; it contributes towards 40% of curative treatment for cancer. The main goal of radiation therapy is to deprive cancer cells of their multiplication (cell division) potential. Celebrating a century of advances since Marie Curie won her second Nobel Prize for her research into radium, 2011 has been designated the Year of Radiation therapy in the UK. Over the last 100 years, ongoing advances in the techniques of radiation treatment and progress made in understanding the biology of cancer cell responses to radiation will endeavor to increase the survival and reduce treatment side effects for cancer patients. In this review, principles, application and advances in radiation therapy with their biological end points are discussed.
Carbohydrate vaccines as immunotherapy for cancer (2005)

Carbohydrates have established themselves as the most clinically relevant antigens of those tested and subsequently developed for vaccines against infectious diseases. However, in cancer patients, many of the defined carbohydrate antigens are really altered 'self' antigens and for unclear reasons, the body does not react to them immunologically. Although these self antigens have been found to be potentially suitable targets for immune recognition and killing, the development of vaccines for cancer treatment is actually more challenging compared with those for infectious diseases mainly because of the difficulty associated with breaking the body's immunological tolerance to the antigen. These antigens lack the inherent immunogenicity associated with bacterial antigens and, therefore, methods to enhance immunological recognition and induction of immunity in vivo are under investigation. These include defining the appropriate tumour-associated antigen, successfully synthesizing the antigen to mimic the original molecule, inducing an immune response, and subsequently enhancing the immunological reactivity so that all components can work together. This has been successfully accomplished with several glycolipid and glycoprotein antigens using carriers such as keyhole limpet haemocyanin (KLH) together with a saponin adjuvant, QS-21. Not only can high titre IgM and IgG antibodies be induced, which are specific for the antigen used for immunization, but the antibodies can mediate complement lysis. The approaches for synthesis, conjugation, clinical administration and immunological potential are discussed.
Coordinate glycosylation and cell surface expression of glycophorin A during normal human erythropoiesis (1987)

The expression of two epitopes on glycophorin A (GPA) during erythroid development was examined on normal human bone marrow using quantitative flow cytometry. The highly correlated binding of two monoclonal antibodies, one sensitive and the other insensitive to glycosylation, indicated that the two epitopes were coordinately expressed during erythroid development. Both antigens reached a maximum expression during the early normoblast stage and were maintained at a constant amount per cell throughout further maturation to erythrocytes. These data suggest that glycosylation of GPA, as detected by antibodies recognizing blood group (M) and (N) antigens, does not increase during erythroid maturation.
Interferon Therapy for Condylomata Acuminata (1986)

Current therapy for condylomata acuminata (genital warts) is not consistently effective. Therefore, we conducted a randomized, double-blind trial to compare interferon alpha-2b with placebo in the treatment of this disorder. Our rationale was that interferon has both antiproliferative and antiviral properties. The placebo or interferon (1 X 10(6) IU) was injected directly into one to three warts three times weekly for three weeks. The injections were well tolerated by both groups of patients. The side effects of fever, chills, myalgia, headache, fatigue, and leukopenia occurred more commonly in the interferon group than in the placebo group, but such effects rarely disrupted daily routines. Only 13 of 296 patients (4 percent) discontinued therapy because of side effects (11 in the interferon group and 2 in the placebo group). Twenty-six other patients were excluded from analysis because of a loss to follow-up or other deviations from protocol, thus leaving 257 patients in the final evaluation. At one week after the completion of therapy, interferon had produced a large and significantly greater reduction in mean wart area (a 62.4 percent decrease), as compared with placebo (a 1.2 percent increase in mean area) (P less than 0.001). At the conclusion of the study (13 weeks after the completion of therapy), the mean wart area was still decreased 39.9 percent below the initial size in the interferon group, whereas it had increased by 46 percent over base-line measurements in the placebo group (P less than 0.001). At the same time, all treated warts had completely cleared in 36 percent of the interferon recipients and in 17 percent of the placebo recipients (P less than 0.001), whereas treated warts progressed in 13 percent of the interferon recipients and in 50 percent of the placebo recipients (P less than 0.001). We conclude that injection of interferon alpha-2b directly into genital warts appears to be an effective and fairly well-tolerated form of therapy.
Discovery and Development of Respirable Antisense Therapeutics for Asthma (2002)

Respirable antisense oligonucleotides (RASONs) represent a novel class of respiratory therapeutic molecules with the potential to specifically address the challenges posed by the successes of the Human Genome Program, namely, the need to rapidly identify the critical pulmonary disease-relevant drugable targets from the vast pool of 30,000-40,000 human genes and to discover and develop drugs that specifically attack these targets. We have shown that EPI-2010, a RASON targeting the adenosine A1 receptor, a G-protein coupled receptor that has been implicated in the regulation of three major determinants of asthma, can be delivered directly to the target disease tissue as an aerosol formulation. In vivo efficacy, absorption, distribution, metabolism, and excretion (ADME), and safety studies of inhaled EPI-2010 employing animal models of human asthma suggest that the RASON approach enables the specific delivery of efficacious, safe, and long-acting doses of phosphorothioate oligonucleotides to the respiratory tract. Moreover, these data indicate that RASONs truly have the potential to address the respiratory drug discovery bottleneck of the postgenomic era, that is, the ability to rapidly validate disease targets and develop pulmonary disease therapeutics for these validated targets.
WT1 contributes to leukemogenesis: Expression patterns in 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia (1997)

The Wilms'-tumor gene WT1 may have a different function from a tumor-suppressor gene in some leukemias. Using the 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat leukemia system, we examined whether WT1 expression was involved during leukemogenesis, since this model enabled us to analyze cells altered by DMBA at various stages of leukemogenesis. By the semi-quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) method, WT1 expression was detected in 15 (71%) of 21 DMBA-induced erythroblastic leukemias. Among 15 WT1-expressing leukemias, GATA-1, which is an erythroid-specific transcription factor and might regulate WT1 expression, was also expressed in 13 cases (p < 0.05). On the other hand, WT1 expression was not detected in any normal or early pre-leukemic rats and was detected in 1 of 8 rats in late pre-leukemic stages. These results showed that cells with a high expression level of WT1 tended to develop into leukemia and that WT1 contributed to leukemogenesis in the late stage, suggesting that the expression of WT1 plays an important role in cell proliferation and in maintaining the viability of some leukemia cells.
Microwave Activation of Enzymatic Catalysis (2008)

Microwave irradiation can be used to regulate biocatalysis. Herein, the utilization of hyperthermophilic enzymes in a microwave reactor is reported. While these enzymes are inactive at low temperatures, they can be activated with microwave irradiation. To the best of our knowledge, this is the first illustration of a specific microwave effect in enzymatic catalysis.