gebhart/patrepeval huggingface dataset:
HEPATIC DYSFUNCTION FOLLOWING T-CELL-DEPLETED ALLOGENEIC BONE MARROW TRANSPLANTATION (1991)

We reviewed the medical records of 97 patients undergoing T cell-depleted allogeneic bone marrow transplantation at our institution from 1984 to 1990 to determine the incidence of hepatic dysfunction, including venoocclusive disease of the liver following BMT. All patients received allogeneic marrow that had been purged with monoclonal antibody to the CD6 surface antigen (T12) and rabbit complement as the sole method of graft-versus-host disease prophylaxis. No additional immunosuppressive agents were routinely administered to these patients. Overall, 55% of patients in our series developed two-fold elevations in serum bilirubin, SGOT, or alkaline phosphatase within the first 30 days following BMT. A five-fold elevation in any liver function test was noted in only 19% of patients. Logistic regression analysis revealed that the presence of GVHD, female sex, and administration of amphotericin B all were independently associated with laboratory evidence of hepatic dysfunction. While LFT abnormalities were common in our series, they were generally mild, and the development of VOD was rare. Only three patients (3.1%) fulfilled clinical criteria sufficient to establish a diagnosis of VOD. Among the 86 patients whose ablative regimen consisted of cyclophosphamide (60 mg/kg x2) and total-body irradiation (1200-1400 cGy in 200 cGy fractions), only 1 patient (1.2%) developed VOD. Our experience suggests that patients undergoing allogeneic BMT are at low risk for VOD and other serious hepatic complications when they receive high-dose cyclophosphamide, fractionated TBI, and T cell-depleted marrow without hepatotoxic medications for GVHD prophylaxis.
Hygienic behaviour of honey bees and its application for control of brood diseases and varroa (1998)

AbstractThere have been very few studies on hygienic behaviour as a mechanism of resistance to American foulbrood since Park, Woodrow, Rothenbuhler, and Rothenbuhler's students published their seminal work. The studies outlined in this part of the review form the core of information from which all later studies on hygienic behaviour have been based.
Report on the 7 th H-CEO Annual Conference in China (2014)

The 7th H-CEO Annual Conference in China was officially initiated in Guangzhou from November 15th to 17th, 2013. Hosted by the periodical office of China Hospital CEO, and co-hosted by the Hospital Association of Guangdong Province and Guangdong Provincial People’s Hospital, the annual conference focused on the theme—the sustainable innovation and mutual development. There were more than 40 sub-forums, roundtable discussions and salons, and over 200 administration officials, CEOs of famous tertiary Grade 3A hospital, and management experts were invited to make speeches. More than 3,000 senior managers of hospitals got together in Guangzhou again, talking freely about the progress of health care reformation and the medical industry, sharing the way of managements respectively.
Challenges and opportunities for enhancing sustainable cowpea production: proceedings of the World Cowpea Conference III held at the International Institute of Tropical Agriculture (IITA), Ibadan, Nigeria, 48 September 2000 (2002)

A number of recent studies have added further information on the genetics of important traits in cowpea. These include inheritance of qualitative traits such as plant pigmentation; flower colour, seed colour, seed coat texture, resistance to rust, scab, smut, nematode, severe mosaic virus, Striga, Alectra, aphid, bruchid, heat, drought tolerance, and male sterility and quantitative traits such as protein content, seed size, seed yield, and fodder quality. A few studies on linkage and mapping have also been conducted. The gene symbols from recent studies and earlier reports have been collated in a classified trait-based gene index for easy reference. While reviewing the past genetic work, obvious gaps needing further studies have been indicated.
Modeling Visual Patterns by Intergrating Descriptive and Generative Methods (2002)

This paper presents a class of statistical models that integrate two statistical modeling paradigms in the literature: I) Descriptive methods, such as Markov random fields and minimax entropy learning [41] and II) Generative methods, such as principal component analysis, independent component analysis [2] transformed component analysis [11], wavelet coding [27, 5], and sparse coding [30, 24]. In this paper, we demonstrate the integrated framwork by constructing a class of hierarchical models for texton patterns ) the term "texton" was coined by psychologist Julez in the early 80's). At the bottom level of the model, we assume that an observed texture image is generated by multiple hidden "texton maps", and textons on each map are translated, scaled, stretched, and oriented versions of a window function, like mini-templates or wavelet bases. The texton maps generate the observed image by occlusion or linear superposition. this bottom level of the model is generative in nature. At the top level of the model, the spatial arrangements of the textons in the texton maps are characterized by minimax entropy principle, which leads to embellished versions of Gibbs point rocess [34]. The top level of the model is descriptive in nature. We demonstrate the integrated model by a set of experiments.
Apparent Viscosity Direct from Marsh Funnel Test (2014)

Accurate and simple techniques for measurement of fluid rheological properties are important for field operations in the oil industry. Marsh Funnels are popular quality-control tools used in the field for drilling fluids and they offer a simple, practical alternative to viscosity measurement. In the normal measurements, a single point (drainage time) is used to determine an average viscosity; little additional information is extracted regarding the non-Newtonian behavior of the fluid.Here, a new model is developed and used to determine the rheological properties of drilling muds and other non-Newtonian fluids using data of fluid density and drainage time collected from a Marsh Funnel as a function of viscosity. The funnel results for viscosity compare favorably to the values obtained from a commonly-used Fann 35 viscometer. Different quantities of bentonite, barite and other additives which have been used to prepare many samples. Empirical equations are obtainedμapp. = ρ (t – 28) and μapp. = -0.0118t2 + 1.6175t - 32.168,where apparent viscosity (μapp.) in (cp), Marsh funnel time (t) in seconds and the density (ρ) in gm/cm3.
Physical activity in epidemiology: moving from questionnaire to objective measurement (2006)

Physical activity can best be measured by a combination of activity monitors, questionnaires, and analytical techniques
The role of vaccines in the control of STDs: HPV vaccines. (1996)

Prophylactic vaccines for genital human papillomavirus (HPV) infection have been shown to be feasible in animal models, and suitable vaccine material based on virus-like particles can be produced in bulk at reasonable cost. Initiation of phase III clinical trials will follow definition of trial outcome measures through further epidemiological studies, and development of assays of host protective immunity. Vaccines could in principle eliminate HPV-related disease, as the human race is the only natural host for the relevant papillomaviruses (PVs). Therapeutic vaccines for genital HPV infection are also possible, but have not yet been demonstrated as feasible in practice because the choice of vaccine antigens is difficult, the method of their optimal delivery is uncertain, and the nature of the relevant antiviral immunity is unknown. PV species specificity will require trials to be conducted in man, which will slow definition of an ideal vaccine.
Metabolic Obesity: The Paradox Between Visceral and Subcutaneous Fat (2006)

In contrast to the accumulation of fat in the gluteo-femoral region, the accumulation of fat around abdominal viscera and inside intraabdominal solid organs is strongly associated with obesity-related complications like Type 2 diabetes and coronary artery disease. The association between visceral adiposity and accelerated atherosclerosis was shown to be independent of age, overall obesity or the amount of subcutaneous fat. Recent evidence revealed several biological and genetic differences between intraabdominal visceral-fat and peripheral subcutaneous-fat. Such differences are also reflected in their contrasting roles in the pathogenesis of obesity-related cardiometabolic problems, in either lean or obese individuals. The functional differences between visceral and the subcutaneous adipocytes may be related to their anatomical location. Visceral adipose tissue and its adipose-tissue resident macrophages produce more proinflamatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and less adiponectin. These cytokines changes induce insulin resistance and play a major role in the pathogenesis of endothelial dysfunction and subsequent atherosclerosis. The rate of visceral fat accumulation is also different according to the individual's gender and ethnic background; being more prominent in white men, African American women and Asian Indian and Japanese men and women. Such differences may explain the variation in the cardiometabolic risk at different waist measurements between different populations. However, it is unclear how much visceral fat reduction is needed to induce favorable metabolic changes. On the other hand, peripheral fat mass is negatively correlated with atherogenic metabolic risk factors and its selective reduction by liposuction does improve cardiovascular risk profile. The increasing knowledge about body fat distribution and its modifiers may lead to the development of more effective treatment strategies for people with/or at high risk for Type 2 diabetes and coronary artery disease. These accumulating observations also urge our need for a new definition of obesity based on the anatomical location of fat rather than on its volume, especially when cardiometabolic risk is considered. The term "Metabolic Obesity", in reference to visceral fat accumulation in either lean or obese individuals may identify those at risk for cardiovascular disease better than the currently used definitions of obesity.
Synthesis and Characterization of New Chiral Schiff Base Complexes with Diiminobinaphthyl or Diiminocyclohexyl Moieties as Potential Enantioselective Epoxidation Catalysts (1996)

New chiral Schiff base complexes have been obtained by condensation of 2,2'-diamino-1,1'-binaphthalene or 1,2-diaminocyclohexane and various salicylaldehydes and by subsequent metalation with manganese, iron, cobalt, nickel, copper, or zinc. The complete (1)H and (13)C NMR characterization of the ligands is reported, as are the X-ray crystal structures of (1R,2R)-(-)-N,N'-bis[3-(N,N-dimethylamino)salicylidene]-trans-1,2-cyclohexanediimine and [(1R,2R)-(-)-N,N'-bis(salicylidene)-trans-1,2-cyclohexanediiminato]copper(II). The new chiral manganese complexes have been evaluated in the oxygenation of prochiral olefins and sulfides using sodium hypochlorite, hydrogen peroxide, or N-methylmorpholine N-oxide/m-chloroperbenzoic acid as oxidant.
As Questions Grow, Duke Halts Trials, Launches Investigation (2010)

A pair of biostatisticians' questions about a prominent genetics group at Duke University have led Duke to investigate the researcher in question, and there are calls for a general review of the field.
Retroviral-mediated transfer and amplification of a functional human factor VIII gene (1990)

Hemophilia A results from a deficiency in factor VII (FVIII), a cofactor in the intrinsic pathway of blood coagulation. As an approach toward genetic therapy of this disease, we constructed a retroviral vector encoding human FVIII and a selectable and amplifiable genetic marker, human adenosine deaminase (Ada). A retrovirus packaging line was transfected with this vector and stable transformants were selected for Ada expression. Isolated transformants produced both FVIII activity in the conditioned medium and retrovirus capable of transferring the Ada selectable marker and FVIII expression to the mouse 3T3 fibroblasts. Selection of virus-producer cell lines for increasing levels of Ada expression yielded a 20-fold increase in both FVIII expression and viral titer. Similarly, selection of infected 3T3 fibroblasts for Ada gene amplification yielded a 20-fold increase in FVIII expression. The results demonstrate the feasibility of retrovirus-mediated transfer of human FVIII, and also the utility of selection for gene amplification to increase retrovirus titers in producer cell lines as well as expression levels in infected cells.
Electron Transfer from the Singlet and Triplet Excited States of Ru(dcbpy)2(NCS)2into Nanocrystalline TiO2Thin Films (2002)

Time-resolved absorption spectroscopy was used to study the femtosecond and picosecond time scale electron injection from the excited singlet and triplet states of Ru(dcbpy)2(NCS)2 (RuN3) into titanium dioxide (TiO2) nanocrystalline particle film in acetonitrile. The fastest resolved time constant of ∼30 fs was shown to reflect a sum of two parallel ultrafast processes, nonergodic electron transfer (ET) from the initially excited singlet state of RuN3 to the conduction band of TiO2 and intersystem crossing (ISC). The branching ratio of 1.5 between the two competing processes gives rate constants of 1/50 fs-1 for ET and 1/75 fs-1 for ISC. Following the ultrafast processes, a minor part of the electron injection (40%) occurs from the thermalized triplet state of RuN3 on the picosecond time scale. The kinetics of this slower phase of electron injection is nonexponential and can be fitted with time constants ranging from ∼1 to ∼60 ps.
A one-step purification of membrane proteins using a high efficiency immunomatrix. (1982)

A method is described by which an immunoaffinity matrix was constructed by binding antibody directly or indirectly to protein A-Sepharose 4B followed by cross-linking of the complex with dimethyl pimelimidate. This allows optimal spatial orientation of antibodies and, thus, maximum antigen binding efficiency. The affinity matrices were stable to high and low pH buffers without any significant antibody loss. The optimal conditions of antibody saturation, cross-linker concentration, and elution system were established and affinity columns made with the monoclonal antibodies J5, W6/32, and OKT9 for one-step isolation of the common acute lymphoblastic leukemia-associated antigen, HLA-AB antigens, and transferrin receptor, respectively, from cell lysates. The same methodology was also applied to immobilize transferrin with polyvalent anti-transferrin antibodies. This was then used to isolate the transferrin receptor from cell lysates.
Contact potential difference measurements of doped organic molecular thin films (2004)

The possibility of nonequilibrium conditions in doped organic molecular thin films is investigated using a combination of ultraviolet photoemission spectroscopy (UPS) and contact potential difference measurements. Surface or interface photovoltage is of particular concern in materials with large band gap and appreciable band (or energy level) bending at interfaces. We investigate here zinc phthalocyanine (ZnPc) and N,N′-diphenyl-N,N′-bis(1-naphthyl)-1,1′biphenyl-4,4″ diamine (α-NPD) p-doped with the acceptor molecule, tetrafluorotetracyanoquinodimethane (F4-TCNQ). In both cases, we observe an upward movement of the vacuum level away from the metal interface with respect to the Fermi level, consistent with the formation of a depletion region. We show that photovoltage is not a significant factor in these doped films, under ultraviolet illumination during UPS. We suggest that the carrier recombination rate in organic films is sufficiently fast to exclude any photovoltage effects at room temperature.
Identification of Novel Serological Biomarkers for Inflammatory Bowel Disease Using Escherichia coli Proteome Chip (2009)

Specific antimicrobial antibodies present in the sera of patients with inflammatory bowel disease (IBD) have been proven to be valuable serological biomarkers for diagnosis/prognosis of the disease. Herein we describe the use of a whole Escherichia coli proteome microarray as a novel high throughput proteomics approach to screen and identify new serological biomarkers for IBD. Each protein array, which contains 4,256 E. coli K12 proteins, was screened using individual serum from healthy controls (n = 39) and clinically well characterized patients with IBD (66 Crohn disease (CD) and 29 ulcerative colitis (UC)). Proteins that could be recognized by serum antibodies were visualized and quantified using Cy3-labeled goat anti-human antibodies. Surprisingly significance analysis of microarrays identified a total of 417 E. coli proteins that were differentially recognized by serum antibodies between healthy controls and CD or UC. Among those, 169 proteins were identified as highly immunogenic in healthy controls, 186 proteins were identified as highly immunogenic in CD, and only 19 were identified as highly immunogenic in UC. Using a supervised learning algorithm (k-top scoring pairs), we identified two sets of serum antibodies that were novel biomarkers for specifically distinguishing CD from healthy controls (accuracy, 86 +/- 4%; p < 0.01) and CD from UC (accuracy, 80 +/- 2%; p < 0.01), respectively. The Set 1 antibodies recognized three pairs of E. coli proteins: Era versus YbaN, YhgN versus FocA, and GabT versus YcdG, and the Set 2 antibodies recognized YidX versus FrvX. The specificity and sensitivity of Set 1 antibodies were 81 +/- 5 and 89 +/- 3%, respectively, whereas those of Set 2 antibodies were 84 +/- 1 and 70 +/- 6%, respectively. Serum antibodies identified for distinguishing healthy controls versus UC were only marginal because their accuracy, specificity, and sensitivity were 66 +/- 5, 69 +/- 5, and 61 +/- 7%, respectively (p < 0.04). Taken together, we identified novel sets of serological biomarkers for diagnosis of CD versus healthy control and CD versus UC.
Bupropion for Weight Loss: An Investigation of Efficacy and Tolerability in Overweight and Obese Women (2001)

Bupropion was more effective than placebo in achieving weight loss at 8 weeks in overweight and obese adult women in this preliminary study. Initial responders to bupropion benefited further in the continuation phase.
Heme Oxygenase-1 in Lung Disease (2010)

The lungs are a major target for various inflammatory, oxidative, carcinogenic or infectious stressors, which result in a range of lung diseases. Induction of heme oxygenase-1 (HO-1) during acute and chronic lung processes is a crucial defense mechanism. HO-1 catalyzes the degradation of free cellular heme to iron, carbon monoxide (CO) and biliverdin which is eventually converted to bilirubin by biliverdin reductase. In addition to the degradation of free heme, a pro-oxidant, HO-1 exerts anti-oxidant, anti-inflammatory and anti-apoptotic properties via its reaction products. This review summarizes the regulation and protective roles of HO-1 and its reaction products in several in vitro and in vivo lung disease models, including acute lung injury, ischemia-reperfusion (IR)-induced lung injury, cigarette smoke and chronic obstructive pulmonary disease (COPD), pulmonary arterial hypertension (PAH), lung cancer and asthma. The therapeutic applications of HO-1 in the lung as well as potential complications of excessive HO-1 induction are also covered. In summary, the HO-1 system is a powerful endogenous defense strategy with immense therapeutic potential against a range of lung diseases if optimal levels and tissue targeting can be achieved.
In Vitro Reconstitution of Recognition and Activation Complexes between Interleukin-6 and gp130 (2001)

Gp130 is a shared signal-transducing receptor for a family of four-helix cytokines, of which interleukin-6 is a prototypic member. IL-6-type cytokines activate gp130 to elicit downstream intracellular JAK/STAT signaling cascades through formation of hetero-oligomeric receptor complexes. Interleukin-6 must first complex with its specific alpha-receptor (Ralpha) in order to bind and activate gp130. We have dissected the extracellular activation pathway of human gp130 by human IL-6 through reconstitution of soluble complexes representing intermediate and final states in the hierarchical assembly of the IL-6/IL-6Ralpha/gp130 signaling complex. To isolate these hetero-complexes, we have applied a protein engineering strategy of covalently linking IL-6 to its Ralpha, which results in a "hyperactive" single-chain complex (hyper-IL-6) which we express in both Escherichia coli and insect cells. We have determined that IL-6/IL-Ralpha and the cytokine-binding homology region (CHR) of gp130 (D2D3) form a stable trimolecular "recognition" complex (trimer) consisting of 1IL-6,1 IL-6Ralpha, and 1 gp130-CHR. Addition of the N-terminal (D1) Ig-like domain (IGD) of gp130 to the CHR results in a transition to a hexameric "activation" complex containing 2 IL-6, 2IL-6Ralpha, and 2 gp130. These results clearly demonstrate that the recognition and activation complexes are disparate hetero-oligomeric molecular species linked by the recruitment of the gp130 IGD by the unique site III epitope present on all gp130-class cytokines. The results of these studies are relevant to other members of the IL-6 family of gp130-cytokines and address a longstanding question concerning the respective roles of the gp130 CHR and IGD in assembly of the active signaling oligomer.
Proteolytic enzyme treatment reduces glomerular immune deposits and proteinuria in passive Heymann nephritis. (1986)

We investigated the effect of proteolytic enzyme treatment on the course of passive Heymann nephritis (PHN). PHN was induced by intravenous injection of Heymann antibody into Sprague Dawley rats. Protease-treated rats received intraperitoneal chymopapain and subtilisin. In rats given subnephritogenic doses of Heymann antibody (5 or 10 mg, insufficient to cause proteinuria), glomerular immune deposits were assessed by immunofluorescence and electron microscopy. In rats given 5 mg Heymann antibody and treated with protease in the heterologous phase of the disease (days 1-7), fewer animals were positive for rabbit IgG and rat IgG, as determined by immunofluorescence on day 12, compared with controls (p less than 0.01). Rats given 10 mg Heymann antibody and treated on days 1-5 were less frequently positive for rabbit IgG on day 5 than controls (p less than 0.05). When treatment was given on days 6-12 (autologous phase), fewer rats had glomerular rabbit and rat IgG compared with controls (p less than 0.025). Protease treatment of rats given nephritogenic doses of Heymann antibody (greater than or equal to 40 mg, causing proteinuria) did not result in significant differences in immunofluorescence deposits. However, protease treatment significantly reduced the number of electron dense deposits at all doses of antibody (p less than 0.01). Furthermore, rats given 60 mg Heymann antibody followed by enzyme treatment in the heterologous phase (days 1-7) or throughout the autologous phase (days 6-18) had significantly reduced protein excretion during the autologous phase compared with control rats (p less than 0.05). After onset of significant proteinuria on day 15 in rats given 40 mg Heymann antibody and treated from day 15 until day 25, there was significantly less (p less than 0.05) proteinuria on days 21-22 and 24-25 than in control rats; thus, enzymes could reverse proteinuria. In normal rats, administration of proteases did not have significant effects on urinary protein excretion, serum creatinine, or renal morphology, nor did protease affect anti-rabbit IgG antibody production in rats injected with Heymann antibody. The overall results indicate that proteolytic enzyme treatment can prevent or remove glomerular immune deposits and can prevent or reverse proteinuria.
Quetiapine Improves Sleep Disturbances in Combat Veterans With PTSD (2005)

Robert, Sophie PharmD*†; Hamner, Mark B. MD*†; Kose, Samet MD†; Ulmer, Helen G. MSN*†; Deitsch, Sarah E. PhD†; Lorberbaum, Jeffrey P. MD*† Author Information