gebhart/patrepeval huggingface dataset:
Metallo‐Supramolecular Block Copolymers (2007)

Abstract Supramolecular copolymers have become of increasing interest in recent years for the search of new materials with tunable properties. In particular, metallo‐supramolecular block copolymers—copolymers in which the blocks are linked together by a metal–ligand complex—have seen important progresses, allowing better control over the synthetic strategies for various architectures, and providing a better understanding of the parameters governing their self‐assembly. We review here recent developments on the synthesis and self‐assembly of such materials achieved in this field.
Synthesis of Core‐Crosslinked Nanoparticles with Controlled Cylindrical Shape and Narrowly‐Dispersed Size via Core‐Shell Brush Block Copolymer Templates (2007)

Core-crosslinked nanocylinders with well-defined shape and narrowly-dispersed size are prepared by using S2Cl2 to react with the alkenyl functionalities of the PNb-g-PIp-based core domain of cylindrical core-shell brush block copolymer, PNb-g-PIp-b-PtBA (see figure). This strategy potentially may be further extended by using brush copolymer templates having different compositional, structural and topological features for the synthesis of a broad variety of crosslinked nanostructures with diverse shapes and sizes.
Slow light in photonic crystal waveguides (2007)

The physical principles behind the phenomenon of slow light in photonic crystal waveguides, as well as their practical limitations, are discussed and put into context. This includes the nature of slow light propagation, its bandwidth limitation, the scaling of linear and nonlinear interactions with the slowdown factor as well as issues such as losses, coupling into and the tuning of slow modes. Applications in all-optical signal processing appear to be the most promising outcome of the phenomena discussed.
Effect of Intragastric Temperature Changes upon Gastric Blood Flow. (1959)

A method has been described for estimating changes in gastric blood flow by direct measurement of gastric venous return through the splenic vein. Blood flow, attending depression of gastric wall temperature to 15–16°C was decreased by a mean value of 66.2% in those animals where some venous collateral was retained and by 68% where total venous isolation was achieved. Flows increased to 48°C. Return of gastric wall temperature to 38°C was followed by restitution of flows to approximately control levels.
A highly integrated low-power 2.4GHz transceiver using a direct-conversion diversity receiver in 0.18&#x00B5;m CMOS for IEEE802.15.4 WPAN (2009)

The IC presented in this paper is a highly integrated low-power RF transceiver for wireless sensor networks (WSN) compliant with the IEEE 802.15.4 2.4GHz WPAN standard. It contains a radio controller with sleep timer and can perform higher-level MAC functions such as beacon detection and network timing synchronisation autonomously, thereby enabling significant power savings in the overall system. The primary design goal for the receive path is to achieve excellent channel selectivity and dynamic range combined with good sensitivity at very low power consumption, all of which are important parameters for the reliable operation of WSN in the harsh 2.4GHz ISM band. The receiver uses a direct-conversion architecture and offers up to 20dB improved interference rejection in the adjacent channels compared to recently published WPAN transceivers based on the low-IF architecture. Further emphasizing WSN reliability, the receiver supports switched antenna diversity to mitigate multipath fading. Implemented in a 1P6M 0.18mum RFCMOS process, the IC occupies a die area of less than 5.9mmA It operates with a supply voltage from 1.8V to 3.6V, draws 16.8mA in receive mode and 18mA when transmitting at 3dBm.
Oxygen free radicals and congestive heart failure. (1991)

Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.
Molecular cloning and sequence analysis of human placental alkaline phosphatase. (1986)

The complete amino acid sequence of the precursor and mature forms of human placental alkaline phosphatase have been inferred from analysis of a cDNA. A near full-length PLAP cDNA (2.8 kilobases) was identified upon screening a bacteriophage lambda gt11 placental cDNA library with antibodies against CNBr fragments of the enzyme. The precursor protein (535 amino acids) displays, after the start codon for translation, a hydrophobic signal peptide of 21 amino acids before the amino-terminal sequence of mature placental alkaline phosphatase. The mature protein is 513 amino acids long. The active site serine has been identified at position 92, as well as two putative glycosylation sites at Asn122 and Asn249 and a highly hydrophobic membrane anchoring domain at the carboxyl terminus of the protein. Significant homology exists between placental alkaline phosphatase and Escherichia coli alkaline phosphatase. Placental alkaline phosphatase is the first eukaryotic alkaline phosphatase to be cloned and sequenced.
A novel, nonoxidative method for the conversion of aldehydes to esters (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel, nonoxidative method for the conversion of aldehydes to estersStephen R. Wilson, Soosan Tofigh, and Raj N. MisraCite this: J. Org. Chem. 1982, 47, 7, 1360–1361Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/jo00346a044https://doi.org/10.1021/jo00346a044research-articleACS PublicationsRequest reuse permissionsArticle Views574Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling (2005)

Angiogenesis, the development of new blood vessels from preexisting vessels, is crucial to tissue growth, repair, and maintenance. This process begins with the formation of endothelial cell sprouts followed by the proliferation and migration of neighboring endothelial cells along the preformed extensions. The initiating event and mechanism of sprouting is not known. We show that the phenotypic expression of negatively charged membrane surface in apoptotic cells initiates the formation of directional endothelial cell sprouts that extend toward the dying cells by a mechanism that involves endothelial cell membrane hyperpolarization and cytoskeleton reorganization but is independent of diffusible molecules.
Layer-by-Layer Deposition:  A Tool for Polymer Surface Modification (1997)

Layer-by-layer deposition of polyelectrolytes onto poly(ethylene terephthalate) (PET) film is reported as a method for polymer surface modification. Poly(allylamine hydrochloride) (PAH) and poly(sodium styrenesulfonate) (PSS) were sequentially adsorbed to unmodified (neutral) PET as well as PET samples that had been surface modified to contain carboxylate (PET-CO2-) and ammonium (PET-NH3+) functionality. XPS and contact angle data indicate that the layers are extremely thin (2−6 Å) and stratified to a significant extent. The wettability of the multilayer films is controlled by the outermost polyelectrolyte layer and the thickness of the individual layers (sublayers have an influence in multilayers with thinner layers). The substrate surface chemistry controls the thickness of all of the layers in the multilayer assembly as well as the stoichiometry (ammonium ion:sulfonate ion ratio) of the deposition process. The effect of the ionic strength of the polyelectrolyte solutions was studied for the case of the neutral substrate (PET); both the individual layer thickness and deposition stoichiometry are affected by ionic strength. Peel tests indicate that the multilayer assemblies have significant mechanical strength.
Dimerization of Deoxyribonuclease I, Lysozyme and Papain (1982)

Transition of bovine ribonuclease A from its monomeric to a dimeric form changes the pattern of enzymic activity response to ionic strength [Sorrentino, S., Carsana, A., Furia, A., Doskocil, J., and Libonati, M. (1980) Biochim. Biophys. Acta. 609, 40-52]. To see whether this phenomenon could be common to other enzyme-substrate systems, the action of various dimeric and monomeric enzymes (ox pancreas deoxyribonuclease, hog spleen acid deoxyribonuclease, bovine seminal ribonuclease, egg-white lysozyme, and papain) on polyelectrolytic substrates has been studied under different conditions of ionic strength. Dimerization of ox pancreas deoxyribonuclease, lysozyme and papain was obtained by cross-linkage with dimethyl suberimidate. The main results of the investigation, similar to those obtained with ribonuclease A, are the following. 1. Enzyme monomers and dimers show markedly different patterns of activity response to ionic strength at given pH values: the reactions catalyzed by monomeric enzymes are highly modulated by salt, whereas those catalyzed by dimeric enzymes are not. In particular, at the reaction optimum the monomeric form of an enzyme is significantly more active than the dimeric one. 2. The optimum of the reaction catalyzed by a dimeric enzyme is shifted to higher ionic strengths in comparison with that of the reaction catalyzed by a monomeric enzyme. A model is proposed that could explain these results on the basis of the influence of ionic strength on the intramolecular dynamics of the enzyme molecule and its non-specific interactions with polyelectrolytic substrates.
Boosting and Other Ensemble Methods (1994)

We compare the performance of three types of neural network-based ensemble techniques to that of a single neural network. The ensemble algorithms are two versions of boosting and committees of neural networks trained independently. For each of the four algorithms, we experimentally determine the test and training error curves in an optical character recognition (OCR) problem as both a function of training set size and computational cost using three architectures. We show that a single machine is best for small training set size while for large training set size some version of boosting is best. However, for a given computational cost, boosting is always best. Furthermore, we show a surprising result for the original boosting algorithm: namely, that as the training set size increases, the training error decreases until it asymptotes to the test error rate. This has potential implications in the search for better training algorithms.
Cohort study of atypical pressure ulcers development (2013)

Atypical pressure ulcers (APU) are distinguished from common pressure ulcers (PU) with both unusual location and different aetiology. The occurrence and attempts to characterise APU remain unrecognised. The purpose of this cohort study was to analyse the occurrence of atypical location and the circumstances of the causation, and draw attention to the prevention and treatment by a multidisciplinary team. The cohort study spanned three and a half years totalling 174 patients. The unit incorporates two weekly combined staff meetings. One concentrates on wound assessment with treatment decisions made by the physician and nurse, and the other, a multidisciplinary team reviewing all patients and coordinating treatment. The main finding of this study identified APU occurrence rate of 21% within acquired PU over a three and a half year period. Severe spasticity constituted the largest group in this study and the most difficult to cure wounds, located in medial aspects of knees, elbows and palms. Medical devices caused the second largest occurrence of atypical wounds, located in the nape of the neck, penis and nostrils. Bony deformities were the third recognisable atypical wound group located in shoulder blades and upper spine. These three categories are definable and time observable. APU are important to be recognisable, and can be healed as well as being prevented. The prominent role of the multidisciplinary team is primary in identification, prevention and treatment.
The mTOR Signalling Pathway in Human Cancer (2012)

The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, which are involved in mRNA translation. It is activated by diverse stimuli, such as growth factors, nutrients, energy and stress signals, and essential signalling pathways, such as PI3K, MAPK and AMPK, in order to control cell growth, proliferation and survival. mTORC2 is considered resistant to rapamycin and is generally insensitive to nutrients and energy signals. It activates PKC-α and AKT and regulates the actin cytoskeleton. Deregulation of multiple elements of the mTOR pathway (PI3K amplification/mutation, PTEN loss of function, AKT overexpression, and S6K1, 4EBP1 and eIF4E overexpression) has been reported in many types of cancers, particularly in melanoma, where alterations in major components of the mTOR pathway were reported to have significant effects on tumour progression. Therefore, mTOR is an appealing therapeutic target and mTOR inhibitors, including the rapamycin analogues deforolimus, everolimus and temsirolimus, are submitted to clinical trials for treating multiple cancers, alone or in combination with inhibitors of other pathways. Importantly, temsirolimus and everolimus were recently approved by the FDA for the treatment of renal cell carcinoma, PNET and giant cell astrocytoma. Small molecules that inhibit mTOR kinase activity and dual PI3K-mTOR inhibitors are also being developed. In this review, we aim to survey relevant research, the molecular mechanisms of signalling, including upstream activation and downstream effectors, and the role of mTOR in cancer, mainly in melanoma.
Isolation and Identification of Potential Migrants in Gamma-Irradiated Plastic Laminates by Using GC/MS and GC/IR (1991)

Potential migrants were isolated by Soxhlet extraction from plastic laminates of PETG/PVDC/PE used to make a single-use injection system. Most of compounds were identified from mass spectra by comparison to reference spectra. However, reference spectra were not available for several major compounds in the Soxhlet extract from irradiated test laminates. Those unknown compounds were identified by using both GC/IR and GC/MS. The change in polymer structure due to irradiation was also monitored by using Fourier transform infrared spectroscopy.
Pharmacological management of binge eating disorder: current and emerging treatment options (2012)

Growing evidence suggests that pharmacotherapy may be beneficial for some patients with binge eating disorder (BED), an eating disorder characterized by repetitive episodes of uncontrollable consumption of abnormally large amounts of food without inappropriate weight loss behaviors. In this paper, we provide a brief overview of BED and review the rationales and data supporting the effectiveness of specific medications or medication classes in treating patients with BED. We conclude by summarizing these data, discussing the role of pharmacotherapy in the BED treatment armamentarium, and suggesting future areas for research.
Physiology and clinical applications of platelet growth factors (1999)

Recombinant human thrombopoietin, or pegylated recombinant human megakaryocyte growth and development factor, produces log-linear increases in megakaryocytopiesis and platelet production. Recent clinical studies investigating the efficacy, safety, and cost benefit of administering platelet growth factors indicate that appropriate dosing of pegylated recombinant human megakaryocyte growth and development factor, or recombinant human thrombopoietin, during chemotherapeutic marrow suppression produces these increases in four ways. First, these factors improve ensuant thrombocytopenia without producing platelet-dependent thrombo-occlusive complications. Second, recombinant human thrombopoietin or pegylated recombinant human megakaryocyte growth and development factor mobilize hematopoietic progenitor cells into the peripheral blood. Third, chronic dosing of HIV-infected thrombocytopenic patients with pegylated recombinant human megakaryocyte growth and development factor normalizes peripheral platelet counts without antibody formation. Fourth, the administration of pegylated recombinant human megakaryocyte growth and development factor to normal human volunteer platelet donors increases platelet yields nearly fourfold, with corresponding increases in peripheral platelet counts when transfused into thrombocytopenic recipients. The clinical application of platelet growth factors is continuing to be defined.
Structure of the lipoprotein lipase–GPIHBP1 complex that mediates plasma triglyceride hydrolysis (2018)

Lipoprotein lipase (LPL) is responsible for the intravascular processing of triglyceride-rich lipoproteins. The LPL within capillaries is bound to GPIHBP1, an endothelial cell protein with a three-fingered LU domain and an N-terminal intrinsically disordered acidic domain. Loss-of-function mutations in <i>LPL</i> or <i>GPIHBP1</i> cause severe hypertriglyceridemia (chylomicronemia), but structures for LPL and GPIHBP1 have remained elusive. Inspired by our recent discovery that GPIHBP1's acidic domain preserves LPL structure and activity, we crystallized an LPL-GPIHBP1 complex and solved its structure. GPIHBP1's LU domain binds to LPL's C-terminal domain, largely by hydrophobic interactions. Analysis of electrostatic surfaces revealed that LPL contains a large basic patch spanning its N- and C-terminal domains. GPIHBP1's acidic domain was not defined in the electron density map but was positioned to interact with LPL's large basic patch, providing a likely explanation for how GPIHBP1 stabilizes LPL. The LPL-GPIHBP1 structure provides insights into mutations causing chylomicronemia.
Study of the breeding ecology and behaviour of the Svalbard population of Light-bellied Brent Goose Branta bernicla hrota (1989)

Nesting ecology and behaviour of the Light-bellied Brent Goose was studied on Luroya and adjacent islands in the Tusenoyane group, SE Svalbard, from 13 June to 30 July 1987. On Luroya 38 pairs attempted to nest, and in the whole study area 98 pairs. Estimated median data of laying of first egg was 10 June, and median hatching date 7 July. Mean clutch size in the middle of the incubation period was 4.0 eggs. On Lurtfya nesting success was 25.7%, hatching success 28.6%, and hatching success for the whole study area was c. 24%. Most losses were attributed to predation (62% of all eggs), polar bears being the most severe predators. Until mid July the islands were surrounded by drift ice, and bears occurred regularly. Bears not only damaged nests but also created disturbance in the nesting colony, offering Arctic Skuas opportunity to take eggs from deserted nests. Other losses were due to female nest desertion during late incubation. Post-hatching losses were negligible. 17 pairs of Barnacle Geese nested on an island adjacent to Luroya, and pairs were nest prospecting on Luroya, but were effectively expelled by territorial Brent males. During nesting, territorial Brent males spent most of the time in vigilance, followed by grazing and resting. Intruding avian predators and other geese were vigorously chased out of the territories. On average females were attentive to their nests 91% of the time. The rest of the time was spent foraging and preening in the territory. During nesting, time off the nest increased. Food resources on the islands were poor. Moss constituted the staple part of the diet during nesting and post-hatching, but the geese selected Cochlearia and Saxifraga. In wet moss carpets where most foraging took place, Cochlearia was almost completely depleted. The high predation pressure observed may be the prime factor responsible for the general low reproductive output of the population, as observed in the Danish wintering quarters. It seems that the Barnacle Goose population on Tusenoyane is expanding, and interspecific competition for nest sites and food may arise.
Dehydrogenative silylation of 1,5-dienes with hydrosilanes catalyzed by RhCl(PPh3)3 (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDehydrogenative silylation of 1,5-dienes with hydrosilanes catalyzed by RhCl(PPh3)3Fumitoshi Kakiuchi, Katsuo Nogami, Naoto Chatani, Yoshio Seki, and Shinji MuraiCite this: Organometallics 1993, 12, 12, 4748–4750Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/om00036a013https://doi.org/10.1021/om00036a013research-articleACS PublicationsRequest reuse permissionsArticle Views447Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts