gebhart/patrepeval huggingface dataset:
Grass Herbicide Efficacy as Influenced by Adjuvant, Spray Solution pH, and Ultraviolet Light (1996)

Research was conducted at the Brandon Research Centre to determine the effect of spray solution pH or adjuvants on the efficacy of two cyclohexanedione (CHD) herbicides, clethodim and tralkoxydim, and two aryloxyphenoxypropionate (APP) herbicides, fenoxaprop-P and quizalofop, and if ultraviolet light is a factor influencing their activity. CHD herbicide efficacy decreased as spray solution pH increased above 7. APP herbicide efficacy was not affected by spray solution pH, probably due to their formulation as proherbicide esters. The choice of adjuvant affected CHD herbicide efficacy but not APP herbicide efficacy. Amigo®, Canplus-411® plus ammonium sulfate, and Merge® were usually the most effective adjuvants with the two CHD herbicides. Physical removal of ultraviolet light did not improve APP herbicide efficacy but did improve CHD herbicide efficacy.
Transition‐Metal‐Catalyzed Addition of Heteroatom—Hydrogen Bonds to Alkynes (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases (2000)

We have previously reported that in thrombin-stimulated human platelets, cytosolic phospholipase A(2) (cPLA2) is phosphorylated on Ser-505 by p38 protein kinase and on Ser-727 by an unknown kinase. Pharmacological inhibition of p38 leads to inhibition of cPLA2 phosphorylation at both Ser-505 and Ser-727 suggesting that the kinase responsible for phosphorylation on Ser-727 is activated in a p38-dependent pathway. By using Chinese hamster ovary, HeLa, and HEK293 cells stably transfected with wild type and phosphorylation site mutant forms of cPLA2, we show that phosphorylation of cPLA2 at both Ser-505 and Ser-727 and elevation of Ca(2+) leads to its activation in agonist-stimulated cells. The p38-activated protein kinases MNK1, MSK1, and PRAK1 phosphorylate cPLA2 in vitro uniquely on Ser-727 as shown by mass spectrometry. Furthermore, MNK1 and PRAK1, but not MSK1, is present in platelets and undergo modest activation in response to thrombin. Expression of a dominant negative form of MNK1 in HEK293 cells leads to significant inhibition of cPLA2-mediated arachidonate release. The results suggest that MNK1 or a closely related kinase is responsible for in vivo phosphorylation of cPLA2 on Ser-727.
[Use of the bipolar vessel sealing system in lung resection]. (2003)

The LigaSure sealing system represents a significant advance in dividing the incomplete fissure less than 3 cm, and sufficient homeostasis in close pulmonary arteries smaller than 3 or 4 mm. Results of this evaluation indicate the LigaSure system is a variable alternative to autosure device or clips in pulmonary resection.
Ion wind drag reduction (1983)

In order to study the effect of ion wind on viscous drag, the equations of electrogasdynamics are solved numerically assuming the flow is incompressible, the electric field is steady and that the fluid velocity is negligible compared to ion drift velocity. The results obtained to date in a continuing theoretical and experimental research program are presented.
Roles of Cytosolic Hsp70 and Hsp40 Molecular Chaperones in Post-translational Translocation of Presecretory Proteins into the Endoplasmic Reticulum (2003)

Hsp70 molecular chaperones and their co-chaperones work together in various cellular compartments to guide the folding of proteins and to aid the translocation of proteins across membranes. Hsp70s stimulate protein folding by binding exposed hydrophobic sequences thereby preventing irreversible aggregation. Hsp40s stimulate the ATPase activity of Hsp70s and target unfolded proteins to Hsp70s. Genetic and biochemical evidence supports a role for cytosolic Hsp70s and Hsp40s in the post-translational translocation of precursor proteins into endoplasmic reticulum and mitochondria. To gain mechanistic insight, we measured the effects of Saccharomyces cerevisiae Ssa1p (Hsp70) and Ydj1p (Hsp40) on the translocation of histidine-tagged prepro-alpha-factor (ppalphaF6H) into microsomes. Radiolabeled ppalphaF6H was affinity purified from wheat germ translation reactions (or Escherichia coli) to remove endogenous chaperones. We demonstrated that either Ssa1p or Ydj1p stimulates post-translational translocation by preventing ppalphaF6H aggregation. The binding and/or hydrolysis of ATP by Ssa1p were required to maintain the translocation competence of ppalphaF6H. To clarify the contributions of membrane-bound and cytosolic Ydj1p, we compared the efficiency of chaperone-dependent translocation into wild-type and Ydj1p-deficient microsomes. Neither soluble nor membrane-bound Ydj1p was essential for post-translational protein translocation. The ability of Ssa1p, Ydj1p, or both chaperones to restore the translocation competence of aggregated ppalphaF6H was negligible.
Towards a benchmark for RGB-D SLAM evaluation (2011)

image sequences and the ground-truth camera trajectories with the goal to establish a benchmark for the evaluation of visual SLAM systems. Our dataset contains the color and depth images of a Microsoft Kinect sensor and the groundtruth trajectory of camera poses. The data was recorded at full frame rate (30 Hz) and sensor resolution (640x480). The ground-truth trajectory was obtained from a high-accuracy motion-capture system with eight high-speed tracking cameras (100 Hz). Further, we provide the accelerometer data from the Kinect. Finally, we propose an evaluation criterion for measuring the quality of the estimated camera trajectory of visual SLAM systems. (a) Typical office scene (b) Motion capture system
Introduction (2012)

At a young age, I lived very close to my grandmothers and I used to visit them often. Both of my grandmothers were very skilled in textile handcrafts and, along with my mother, were firm believers that sewing is one of those basic skills that everyone should know. One grandmother was amazing at crocheting and needlepoint, and the other one was very skilled in weaving and loved quilting. I've been very interested in everything practical and artistic since I was young, and my grandmothers were patient enough to teach me their skills.
Surface-enhanced Raman spectrometry for trace organic analysis (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface-enhanced Raman spectrometry for trace organic analysisTuan. Vo-Dinh, M. Y. K. Hiromoto, G. M. Begun, and R. L. MoodyCite this: Anal. Chem. 1984, 56, 9, 1667–1670Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://doi.org/10.1021/ac00273a029Request reuse permissionsArticle Views886Altmetric-Citations246LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. (1991)

The KRE6 gene product is required for synthesis of the major beta-glucans of the yeast cell wall, as mutations in this gene confer reduced levels of both the (1----6)- and (1----3)-beta-D-glucan polymers. Cloning and sequencing of KRE6 reveals a gene encoding a predicted 80-kDa protein with a central transmembrane domain and the topology of a type II membrane protein. Null mutants of KRE6 grow slowly, have larger cells, and show a reduction in alkali-insoluble wall glucans. The mutants show good viability and are not osmotically sensitive, but they are more susceptible to beta-glucanase digestion and mechanical stress than wild-type cells. The specific activity of the GTP-dependent, membrane-associated, in vitro (1----3)-beta-glucan synthase is reduced 50% in kre6 null mutants, and this reduction correlates with the mutation in meiotic tetrads. Transformants of kre6 null mutants with a KRE6 gene expressed from a centomere-based vector show a 4- to 5-fold increase in in vitro (1----3)-beta-glucan synthase activity over transformants with the vector alone. The phenotype and structure of the KRE6 product, Kre6p, suggest that Kre6p may be a beta-glucan synthase, and if so, it implies that beta-glucan synthases are functionally redundant in yeast. Alternatively, Kre6p may be part of a single multiprotein glucan synthase or modulate its activity. Use of KRE6 should permit a genetic analysis of eukaryotic (1----3)-beta-glucan synthesis.
Multiple phenotypes associated with Myc-induced transformation of chick embryo fibroblasts can be dissociated by a basic region mutation (1996)

Chimaeric alleles were constructed to assay the biological functions of an N-terminal deletion and C-terminal mutations which were found in a naturally occurring mutant of feline vMyc, T17. The mutant alleles were assayed for their ability to transform chick embryo fibroblasts in vitro by a number of criteria, namely the ability to induce morphological transformation, an accelerated growth rate and growth in soft agar. Feline cMyc could transform the avian cells, whilst T17 vMyc could not, and the N-terminal deletion was responsible for conferring the primary transformation defect on the mutant protein. The C-terminal mutations which consist of a point mutation adjacent to the nuclear localisation signal and a point mutation/amino acid insertion within the basic region (BR) could, however, dissociate the Myc-induced parameters of transformation. This effect was a specific function of the BR mutation alone, and the mutation could be transferred into avian cMyc with comparable biological consequences. The BR mutation did not disrupt the sequence specific DNA binding activity of the protein in vivo, despite exerting a biological effect. These data suggest a novel phenotype where the mutation may affect a subset of Myc-regulated genes through altered DNA binding specificity or protein-protein interactions.
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin (1997)

The ob/ob mouse is genetically deficient in leptin and exhibits a phenotype that includes obesity and non-insulin-dependent diabetes mellitus. This phenotype closely resembles the morbid obesity seen in humans. In this study, we demonstrate that a single intramuscular injection of a recombinant adeno-associated virus (AAV) vector encoding mouse leptin (rAAV-leptin) in ob/ob mice leads to prevention of obesity and diabetes. The treated animals show normalization of metabolic abnormalities including hyperglycemia, insulin resistance, impaired glucose tolerance, and lethargy. The effects of a single injection have lasted through the 6-month course of the study. At all time points measured the circulating levels of leptin in the serum were similar to age-matched control C57 mice. These results demonstrate that maintenance of normal levels of leptin (2-5 ng/ml) in the circulation can prevent both the onset of obesity and associated non-insulin-dependent diabetes. Thus a single injection of a rAAV vector expressing a therapeutic gene can lead to complete and long-term correction of a genetic disorder. Our study demonstrates the long-term correction of a disease caused by a genetic defect and proves the feasibility of using rAAV-based vectors for the treatment of chronic disorders like obesity.
Brain image registration based on cortical contour mapping (2005)

The authors address the problem of brain image registration, and they present a new, nonlinear registration technique. In the first step of the authors' technique they obtain a point-to-point mapping between the outer cortical contours of the brain images using an elastic string algorithm. In the second step the authors register the two images based on the point-to-point correspondence established in the first step. They propose a new, nonlinear registration transformation, which is based on a spatially variable scaling and relation that can describe highly nonlinear deformations. Finally, the authors test their algorithm on two different registration problems: they first consider the registration of a postmortem photograph of a baboon brain cross-section and then an MR image of approximately the same cross-section.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Molecular electronics: from devices and interconnect to circuits and architecture (2003)

As the dominating CMOS technology is fast approaching a "brick wall," new opportunities arise for competing solutions. Nanoelectronics has achieved several breakthroughs lately and promises to overcome many of the limitations intrinsic to current semiconductor approaches. Most of the results in this area reported until now focus on devices and interconnect; this work goes several steps further and presents issues related to circuits and architecture. Based on proposed nanoscale interconnect and device structures, we explore the design space available to the nanoelectronic circuit designer and system architect.
Invited Paper Gate Oxide Scaling Limits and Projection (1996)

MOSFET gate oxide .scaling limits are examined with respect to time-dependent breakdown, defects. plasma process damage, mobility degradation, poly-gate depletion, inversion layer thickness, tunneling leakage, charge trapping, and gate delay. It is projected that the operating field will stay around 5MV/cm for reliability and optimum speed. Tunneling leakage prevents scaling below 2nm. which is sufficient for MOSFET scaling to 0.05~.
IL-21 induces in vivo immune activation of NK cells and CD8+ T cells in patients with metastatic melanoma and renal cell carcinoma (2008)

IL-21 was biologically active at all dose levels administered with evidence of in vivo NK cell and CD8(+) T cell activation.
Accelerometry: providing an integrated, practical method for long-term, ambulatory monitoring of human movement (2004)

Accelerometry offers a practical and low cost method of objectively monitoring human movements, and has particular applicability to the monitoring of free-living subjects. Accelerometers have been used to monitor a range of different movements, including gait, sit-to-stand transfers, postural sway and falls. They have also been used to measure physical activity levels and to identify and classify movements performed by subjects. This paper reviews the use of accelerometer-based systems in each of these areas. The scope and applicability of such systems in unsupervised monitoring of human movement are considered. The different systems and monitoring techniques can be integrated to provide a more comprehensive system that is suitable for measuring a range of different parameters in an unsupervised monitoring context with free-living subjects. An integrated approach is described in which a single, waist-mounted accelerometry system is used to monitor a range of different parameters of human movement in an unsupervised setting.
EFFICACY AND TOLERABILITY OF WEEKLY SUBCUTANEOUS INJECTIONS OF THE FULLY HUMAN ANTI-TNF-ANTIBODY D2E7 IN PATIENTS WITH RHEUMATOID ARTHRITIS-RESULTS OF A PHASE I STUDY (1998)

149
To examine the efficacy and tolerability of weekly s.c. administrations of the new, fully human anti-TNF-alpha antibody D2E7.
24 patients with active rheumatoid arthritis (mean disease duration 10.1 years, mean Disease Activity Score 5.3, mean SWJC 19.9, mean TJC 21.4) have been included in this clinical phase I trial. After a wash-out period of 3 weeks patients received weekly doses of 0.5 mg/kg D2E7 or placebo as s.c. injections for 3 months in a double blinded fashion. Thereafter all patients continued on D2E7 open label in this ongoing study. Non-responders (a drop in the Disease Activity Score of less than 1.2 compared with baseline) or patients who lose their responder status receive s.c. injections at a dose of 1 mg/kg.
So far 300 injections of D2E7 have been given for up to 6 months. Local tolerability seems to be very good in this limited number of patients. A 72 year old patient dropped out during the first treatment weeks due to myocardial infarction (on placebo). Based on pre-liminary data, plasma concentrations of D2E7 after multiple s.c. injections are comparable with those after i.v. injections of D2E7. A first analysis by an independent statistician has revealed a mean reduction in DAS of about 50%, in SWJC of about 60% and in TJC of about 70% for D2E7 treated patients after 2 months.
The s.c. administration of D2E7 has been shown to be safe and efficacious.
Disclosure: work reported in this abstract was supported by: Supported by KNOLL AG, Germany
Synthesis and Solution Properties of Zwitterionic Polymers (2002)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Solution Properties of Zwitterionic Polymers†Andrew B. Lowe and Charles L. McCormickView Author Information Departments of Chemistry and Biochemistry and of Polymer Science, University of Southern Mississippi, Hattiesburg, Mississippi 39406 Cite this: Chem. Rev. 2002, 102, 11, 4177–4190Publication Date (Web):October 25, 2002Publication History Received18 April 2002Published online25 October 2002Published inissue 1 November 2002https://pubs.acs.org/doi/10.1021/cr020371thttps://doi.org/10.1021/cr020371tresearch-articleACS PublicationsCopyright © 2002 American Chemical SocietyRequest reuse permissionsArticle Views13257Altmetric-Citations785LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Copolymers,Monomers,Organic compounds,Polymers,Solution chemistry Get e-Alerts
Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin .alpha.IIb.beta.3 antagonists (1994)

Utilizing conformational constraints in conjunction with various structural considerations, we have synthesized a series of cyclic disulfide peptides that are highly potent and selective antagonists for the platelet integrin alpha IIb beta 3 (GPIIb/IIIa). The affinities of the peptides for alpha IIb beta 3 were determined by platelet aggregation assays and an alpha IIb beta 3 ELISA. Their affinities for alpha 5 beta 1 and alpha v beta 5 integrins were also determined in respective ELISA assays. Structure-activity relationship studies suggest that R-G-D-Ar-R (Ar = hydrophobic residue) is the essential pharmacophore that is responsible for their high alpha IIb beta 3 binding affinity, very high selectivity, and distinct biological properties. One of these analogues, TP9201, has been shown to inhibit platelet-mediated thrombus formation without associated prolongation of template bleeding time. The arginine residue adjacent the carboxy terminus of the R-G-D-Ar sequence could function as the biological effector element that determines this distinct and unexpected biological property.
The ADAMs family of proteins: from basic studies to potential clinical applications (2003)

The ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease domain. Currently, 34 members are known to exist. Approximately 50% of the ADAMs contain a metalloprotease-like domain and some of these have been shown to possess protease activity. Most of the protein substrates identified to date for ADAMs are either integral membrane or extracellular matrix (ECM) proteins. In addition to hydrolysing proteins, a number of ADAMs bind to integrins. The attachment to integrins occurs via the disintegrin domain. Since the ADAMs can play a role in both proteolysis and adhesion, they have been implicated in a variety of biological processes such as sperm-egg fusion, somatic cell-cell adhesion, ectodomain shedding, myoblast fusion and development. Altered expression of certain ADAMs has been associated with a number of diseases including asthma, arthritis, Alzheimer's disease, atherosclerosis and cancer.
Practical ophthalmic microbiology. (1999)

Infection is commonly encountered in everyday ophthalmic practice. It is of great importance that all ophthalmic personnel are familiar with the basic etiologies of these infections, and the basic techniques which are used in diagnosis. When evaluating a patient with possible infection, it is often of great help to be familiar with the normal microbial flora of the human body. This normal flora has been detailed in the article. The assumption is that knowledge of a patient's flora can help guide decisions about the possible etiologies of an infection. When presented with an obvious ocular infection, health care personnel should review the "usual suspects"--that is, the common etiologies for each type of infection. The key to combating ocular infections lies in accurate treatment of the presumed infectious agent. Therefore, the techniques and steps used in the identification of the etiology of an infection should be known to all ophthalmic personnel. The proper sterile techniques of obtaining a specimen from a suspected corneal ulcer or conjunctivitis and the plating of the specimen on specific agar for identification are essential to everyday practice (Figure 8). Patients who will undergo surgery, regardless of the type, are being placed at a special risk for infection. These post-operative infections can destroy the work of the most careful and exact surgical technique. It is an essential part of the procedure that the patient be protected as best they can from subsequent infection. The techniques to reduce the risk of post-operative infection have been detailed above. Proper preparation of a sterile field, sterile draping, and perioperative antibiotics can reduce the chance of a subsequent infection. It is important that these basic steps of care be properly provided to help insure successful surgical outcomes and excellence in health care.