gebhart/patrepeval huggingface dataset:
A Metalens with a Near-Unity Numerical Aperture (2018)

The numerical aperture (NA) of a lens determines its ability to focus light and its resolving capability. Having a large NA is a very desirable quality for applications requiring small light-matter interaction volumes or large angular collections. Traditionally, a large NA lens based on light refraction requires precision bulk optics that ends up being expensive and is thus also a specialty item. In contrast, metasurfaces allow the lens designer to circumvent those issues producing high-NA lenses in an ultraflat fashion. However, so far, these have been limited to numerical apertures on the same order of magnitude as traditional optical components, with experimentally reported NA values of <0.9. Here we demonstrate, both numerically and experimentally, a new approach that results in a diffraction-limited flat lens with a near-unity numerical aperture (NA > 0.99) and subwavelength thickness (∼λ/3), operating with unpolarized light at 715 nm. To demonstrate its imaging capability, the designed lens is applied in a confocal configuration to map color centers in subdiffractive diamond nanocrystals. This work, based on diffractive elements that can efficiently bend light at angles as large as 82°, represents a step beyond traditional optical elements and existing flat optics, circumventing the efficiency drop associated with the standard, phase mapping approach.
Common Policy: A Document Format for Expressing Privacy Preferences (2007)

This document defines a framework for authorization policies controlling access to application-specific data.This framework combines common location-and presence-specific authorization aspects.An XML schema specifies the language in which common policy rules are represented.The common policy framework can be extended to other application domains.Schulzrinne, et al.
Next-Generation Sequencing Platforms (2013)

Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.
Spectral analysis of induced color change on periodically nanopatterned silk films (2009)

We demonstrate controllable structural color based on periodic nanopatterned 2D lattices in pure protein films of silk fibroin. We show here periodic lattices in silk fibroin films with feature sizes of hundreds of nanometers that exhibit different colors as a function of varying lattice spacing. Further, when varying the index of refraction contrast between the nanopatterned lattice and its surrounding environment by applying liquids on top of the lattices, colorimetric shifts are observed. The effect is characterized experimentally and theoretically and a simple example of glucose concentration sensing is presented. This is the first example of a functional sensor based on silk fibroin optics.
Determination of parts-per-billion levels of hydrogen sulfide in air by potentiometric titration with a sulfide ion-selective electrode as an indicator (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of parts-per-billion levels of hydrogen sulfide in air by potentiometric titration with a sulfide ion-selective electrode as an indicatorDewayne L. EhmanCite this: Anal. Chem. 1976, 48, 6, 918–920Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/ac60370a004https://doi.org/10.1021/ac60370a004research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Proposal for solid-state particle detector based on latchup effect (2005)

A novel approach to detect particles by means of a solid-state device susceptible to latchup effects is described. The stimulated ignition of latchup effects caused by external radiation has so far proven to be a hidden hazard. This is proposed as a powerful means of achieving the precise detection and positioning of a broad range of particles with a spatial resolution of 5 µm.
Sympathetic Responses to Induction of Anesthesia in Humans with Propofol or Etomidate (1992)

Anesthetic induction with propofol commonly results in hypotension. This study explored potential mechanisms contributing to hypotension by recording cardiovascular responses including sympathetic neural activity from patients during induction of anesthesia with propofol (2.5 mg.kg-1 plus 200 micrograms.kg-1.min-1) or, for comparison, etomidate (0.3 mg.kg-1 plus 15 micrograms.kg-1.min-1). Twenty-five consenting, nonpremedicated, ASA physical status 1 and 2, surgical patients were evaluated. Measurements of R-R intervals (ECG), blood pressure (radial artery), forearm vascular resistance (plethysmography), and efferent muscle sympathetic nerve activity ([MSNA] microneurography: peroneal nerve) were obtained at rest and during induction of anesthesia. In addition, a sequential bolus of nitroprusside (100 micrograms) followed by phenylephrine (150 micrograms) was used to obtain data to quantitate the baroreflex regulation of cardiac function (R-R interval) and sympathetic outflow (MSNA) in the awake and anesthetized states. Etomidate induction preserved MSNA, forearm vascular resistance, and blood pressure, whereas propofol reduced MSNA by 76 +/- 5% (mean +/- SEM), leading to a reduction in forearm vascular resistance and a significant hypotension. Both cardiac and sympathetic baroslopes were maintained with etomidate but were significantly reduced with propofol, especially in response to hypotension. These findings suggest that propofol-induced hypotension is mediated by an inhibition of the sympathetic nervous system and impairment of baroreflex regulatory mechanisms. Etomidate, conversely, maintains hemodynamic stability through preservation of both sympathetic outflow and autonomic reflexes.
Electrical Impedance of Spin-Coatable Ion Gel Films (2011)

The electrical properties (capacitance, resistance, and conductivity) of ion gel films were examined as a function of film geometry and temperature by using electrical impedance spectroscopy. Ion gel films, which consist of a triblock copolymer, poly (styrene-b-methyl methacrylate-b-styrene) [SMS], and an ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [EMI][TFSI], were deposited by spin coating from ethyl acetate solution. The thickness (2.2-13.4 μm) and the area (0.01-0.06 cm(2)) of the film sandwiched between two gold electrodes were varied systematically to investigate the relation between the electrical properties and the geometry of the film. The resistance (R) was directly proportional to the thickness and the reciprocal area, as expected, whereas the specific capacitance (C') was insensitive to the film geometry. Importantly, the gel polarization time constants (RC, where C = C' × area) were as small as 2.8 μs for 2.2 μm thick ion gel films. Conductivity and capacitance of the film both increase with increasing temperature, with conductivity following the Vogel-Fulcher-Tamman equation, indicating entropically activated behavior, and capacitance at 10 Hz showing Arrhenius-type activation.
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus (2006)

The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele. Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7. FISH analysis demonstrated the translocation of this segment onto the yaa chromosome. The resulting overexpression of Tlr7 increased in vitro responses to Toll-like receptor (TLR) 7 signaling in all yaa-bearing males. B6.yaa mice are not overtly autoimmune, but the addition of Sle1, which contains the autoimmune-predisposing Slam/Cd2 haplotype, causes the development of fatal lupus with numerous immunological aberrations. B6.Sle1yaa CD4 T cells develop the molecular signature for T(FH) cells and also show expression changes in numerous cytokines and chemokines. Disease development and all component autoimmune phenotypes were inhibited by Sles1, a potent suppressor locus. Sles1 had no effect on yaa-enhanced TLR7 signaling in vitro, and these data place Sles1 downstream from the lesion in innate immune responses mediated by TLR7, suggesting that Sles1 modulates the activation of adaptive immunity in response to innate immune signaling.
Presence of CFTR in the conjunctival epithelium (2002)

Apical localization of CFTR in the conjunctival epithelium is consistent with the function of this protein as a chloride channel or as a regulator of channel activity. The identification of CFTR in both bulbar and palpebral portions of the conjunctiva provides evidence that the mechanisms for Cl secretion reside throughout the conjunctiva. This finding suggests that manipulations of the CFTR Cl channel could affect transepithelial Cl transport rates and water movement into the tear film.
Automatic linguistic indexing of pictures by a statistical modeling approach (2003)

Automatic linguistic indexing of pictures is an important but highly challenging problem for researchers in computer vision and content-based image retrieval. In this paper, we introduce a statistical modeling approach to this problem. Categorized images are used to train a dictionary of hundreds of statistical models each representing a concept. Images of any given concept are regarded as instances of a stochastic process that characterizes the concept. To measure the extent of association between an image and the textual description of a concept, the likelihood of the occurrence of the image based on the characterizing stochastic process is computed. A high likelihood indicates a strong association. In our experimental implementation, we focus on a particular group of stochastic processes, that is, the two-dimensional multiresolution hidden Markov models (2D MHMMs). We implemented and tested our ALIP (Automatic Linguistic Indexing of Pictures) system on a photographic image database of 600 different concepts, each with about 40 training images. The system is evaluated quantitatively using more than 4,600 images outside the training database and compared with a random annotation scheme. Experiments have demonstrated the good accuracy of the system and its high potential in linguistic indexing of photographic images.
Convergence and Segregation of the Multiple Rod Pathways in Mammalian Retina (2004)

Using a multidisciplinary approach, we demonstrate that three different pathways are responsible for the transmission of rod signals across the mouse retina. Each pathway serves a primarily nonoverlapping range of stimulus intensities, with ganglion cells receiving either segregated or convergent inputs. For both on-center (ON) and off-center (OFF) ganglion cells, the primary rod pathway carries signals with the lowest threshold, whereas the secondary rod pathway is less sensitive by approximately 1 log unit. In addition, OFF signaling uses a tertiary rod pathway that is approximately 1 log unit less sensitive than the secondary. Although some ganglion cells received rod inputs exclusively from one of the pathways, others showed convergent inputs. Using pharmacological and genetic approaches, we defined classes of ON and OFF ganglion cells for which the scotopic inputs derive only from the primary pathway or from both primary and secondary pathways. In addition, we observed a class of OFF ganglion cell receiving mixed input from primary and tertiary pathways. Interestingly, OFF ganglion cells receiving convergent inputs from all three rod pathways or from the secondary and tertiary pathways together were never observed. Overall, our data show a complex arrangement of convergence and segregation of rod inputs to ganglion cells in the mammalian retina.
Treatment of septic shock with antibodies to tumour necrosis factor. (1993)

The high mortality associated with septic shock has prompted intensive study of the pathophysiological basis of this syndrome in an effort to better understand the processes that lead to tissue injury. One important outcome of this work has been the recognition that the cytokine tumour necrosis factor (TNF) is an important mediator of endotoxin-induced lethality. Accordingly, studies were done which showed that antibodies to TNF could protect animals from death in a variety of model systems, and based on these findings, clinical studies were initiated. This paper reviews the present status of clinical trials of anti-TNF in sepsis. These antibodies appear to be safe, and preliminary experience suggests that they may be effective in some patients with the sepsis syndrome. A final assessment of efficacy must await the large, placebo-controlled trials that are now in progress.
Gene Modification with Hapaxoterministic Restriction Enzymes: Easing the Way (2003)

Subcloning can be extraordinarily easy or extremely difficult. The simplest case requires cleavage of the desired fragment from the DNA in which it is located with one or two restriction enzymes, cleavage of the plasmid that will serve as the ultimate recipient with the same enzymes, and ligation of the fragment to the plasmid. In a somewhat more complicated version of simple cloning, the investigator uses the polymerase chain reaction to amplify the DNA to be subcloned. In this case, restriction sites can be incorporated into the primers used for PCR, generating products with the desired restriction sites located near the ends of the newly synthesized DNA. After cleavage of those sites, the fragment is ready for insertion into an appropriately cut vector. The major disadvantage of the method is the need for sequencing the amplified material, because even the best of the thermostable polymerases makes mistakes that might render the DNA useless for the anticipated application.
Oxygen plasma etching for resist stripping and multilayer lithography (1989)

Oxygen-based plasmas commonly used in resist stripping and multilayer resist patterning are contrasted to highlight the differences involved in these applications. Mechanisms for polymer etching are reviewed, with particular emphasis on silicon-containing resists proposed for bilayer lithography. While silicon-containing materials offer a simpler process than trilayer schemes for improving lithographic resolution, considerable differences in etch behavior among these materials have been observed. Further characterization and fundamental understanding are required before widespread acceptance of silicon-containing resists is achieved.
Characterization of T Lymphocytes Infiltrating Human Pancreas Allograft Affected by Isletitis and Recurrent Diabetes (1992)

We studied a human leukocyte antigen-identical pancreas graft transplanted into an insulin-dependent (type I) diabetic patient shortly after onset of recurrent diabetes to characterize the putative autoreactive T lymphocytes mediating the lesion. The immunohistopathological analysis revealed the presence of isletitis and a selective loss of beta-cells. The isletitis was mostly constituted by CD8+/T-lymphocyte receptor alpha,beta (TCR alpha,beta +) T lymphocytes surrounding and infiltrating the affected islets. CD4-/CD8-/TCR gamma, delta + T lymphocytes were observed within the islets. Incubation of the tissue in 15% interleukin 2 induced the migration and initial expansion of the infiltrating cells (66% CD3+ lymphocytes) for up to 2 wk; most T lymphocytes in this initial isolate were CD4+ (92% CD4+ and 7% CD8+). Long-term anti-CD3 stimulation of this T-lymphocyte population induced the selective growth of CD8+/TCR alpha,beta + (75%) and CD4-/CD8-/TCR gamma,delta + (all V1 delta +) (17%) T lymphocytes. Therefore, this strategy selectively expanded the T lymphocytes, found to be the predominantly islet-infiltrating cells, rather than the lymphocytes predominating in the initial isolate. Anti-CD3 did not stimulate growth of T lymphocytes in cultures of three isletitis-free pancreas graft biopsies. In a control experiment with a CD4(+)-rich T-lymphocyte population, long-term anti-CD3 stimulation and cloning of cytomegalovirus (CMV)-primed peripheral blood mononuclear cells from a CMV+ subject selectively induced the growth of CD4+ T-lymphocyte clones, all CMV specific.(ABSTRACT TRUNCATED AT 250 WORDS)
Biotic and heavy metal stress response in plants: evidence for common signals (2004)

In higher plants, biotic stress (e.g., herbivore or pathogen attack) as well as abiotic stress (in particular heavy metals) often induce the synthesis and accumulation of the same defense-related secondary metabolites. This well-known finding still awaits an explanation regarding the common features of both stress types. In this study, a mechanism is proposed that links reactive oxygen species (ROS) generation with lipid oxidation processes, ultimately resulting in the formation of similar, highly active signalling compounds. The generation of ROS is a common event in both heavy metal treatment and biotic stress although it can depend on quite different, enzymatic and non-enzymatic reactions. Regardless, ROS are involved in the oxidation of unsaturated fatty acids which initiate the formation of oxylipins, a highly variable class of lipid-derived compounds in plants. Oxylipins represent new endogenous signals involved in biotic- and abiotic-induced stress responses.
The therapeutic potential of CXCR4 antagonists in the treatment of HIV (2003)

Since the identification of the chemokine receptors CXCR4 and CCR5 as co-receptors for HIV-1 entry, several antagonists against these receptors have been synthesised. A highly selective CXCR4 antagonist, T22, and its downsized analogues T140 and TC14012, which inhibit X4-HIV-1 infection through their specific binding to CXCR4, have been identified. Besides T22 analogues, several other CXCR4 antagonists have been reported, such as AMD3100, ALX40-4C, KRH-1120 and AMD8664. Discovery of entry inhibitors, such as chemokine antagonists, may lead to the development of a new generation of antiHIV agents, since these inhibitors are thought to be useful for the clinical treatment of HIV-1-infected patients, especially at the late stage of treatment for AIDS patients developing multi-drug-resistant strains. In this review, recent research into CXCR4 antagonists in comparison with development of other antagonists is summarised.
Nicotinic Acetylcholine Receptor Subtypes in the Rat Sympathetic Ganglion: Pharmacological Characterization, Subcellular Distribution and Effect of Pre- and Postganglionic Nerve Crush (2004)

Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in autonomic ganglia, which innervate and control the activity of most visceral organs. By combining ultrastructural, immunocytochemical, and pharmacological analyses, we characterized the nAChR subtypes in the rat superior cervical ganglion (SCG) and the effect of pre- and postganglionic nerve crush on their number in the ganglion and their distribution at the intraganglionic synapses. Binding with radioactive nicotinic ligands, immunoprecipitation, and immunolocalization experiments revealed the presence of different nAChR subtypes: those containing the α3 subunit associated with β4 and/or β2 subunits that bind 3H-Epibatidine with high affinity, and those containing the α7 subunit that bind 125I-αBungarotoxin. After postganglionic nerve crush, the number of nicotinic receptors and immunopositive intraganglionic synapses for each nAChR subunit strongly decreased. Both the number of nAChRs and immunoreactivity recovered 26 days after injury, when regenerating postganglionic fibers had reinnervated the peripheral target organs, as shown by the restoration of tyrosine hydroxylase immunoreactivity in the iris. This observation and the lack of any effect of preganglionic nerve crush on the number of nicotinic receptors suggest that the peripheral targets affect the organization of intraganglionic synapses in adult SCG.
The field matching problem: Algorithms and applications (1996)

To combine information from heterogeneous sources, equivalent data in the multiple sources must be identified. This task is the field matching problem. Specifically, the task is to determine whether or not two syntactic values are alternative designations of the same semantic entity. For example the addresses Dept. of Comput. Sci. and Eng., University of California, San Diego, 9500 Gilman Dr. Dept. 0114, La Jolla, CA 92093 and UCSD, Computer Science and Engineering Department, CA 92093-0114 do designate the same department. This paper describes three field matching algorithms, and evaluates their performance on real-world datasets. One proposed method is the well-known Smith-Waterman algorithm for comparing DNA and protein sequences. Several applications of field matching in knowledge discovery are described briefly, including WEBFIND, which is a new software tool that discovers scientific papers published on the worldwide web. WEBFIND uses external information sources to guide its search for authors and papers. Like many other worldwide web tools, WEBFIND needs to solve the field matching problemn in order to navigate between information sources.