gebhart/patrepeval huggingface dataset:
Amplitude scintillation cycles in a SIRIO satellite-Earth link (1985)

Analysis of amplitude scintillations in an 11.5 GHz SIRIO-Earth link has been performed. The intensity of scintillations has been evaluated for July 1984 by means of scintillation index. The hourly values of this index have been compared to the ground temperature measured in a site close to the vertical projection of the path. Both scintillation index and temperature seem to follow a similar cyclical behaviour. The relationship between the number of occurrences and the value of the index is also represented, together with a two-segment linear-wise approximation.
Flavoridin inhibitsYersinia enterocoliticauptake into fibronectin-adherent HeLa cells (2005)

In this study, three structurally distinct disintegrins (flavoridin, echistatin, kistrin) were used as molecular probes to further characterize the molecular mechanisms underlying Yersinia enterocolitica infection of host cells. The activity of the three disintegrins on Y. enterocolitica uptake into fibronectin-adherent HeLa cells was evaluated at disintegrin doses which were non-cytotoxic and unable to induce cell detachment. Flavoridin resulted to be the most effective in inhibiting bacterial entry into host cells; echistatin was almost 50% less effective than flavoridin, whereas kistrin was definitely inactive. Our results suggest that alpha(5)beta(1) integrin receptor, which binds flavoridin with higher affinity than the other two disintegrins, plays a major role in Y. enterocolitica uptake into HeLa cells. Furthermore, flavoridin binding to this integrin prevented the disruption of the functional complex FAK-Cas, which occurs in the Y. enterocolitica uptake process.
Specifying temporal behavior in hypermedia documents (1993)

Article Free Access Share on Specifying temporal behavior in hypermedia documents Authors: M. Cecelia Buchanan Information Sciences and Technologies Laboratory, Xerox PARC, 3333 Coyote Hill Road, Palo Alto, CA Information Sciences and Technologies Laboratory, Xerox PARC, 3333 Coyote Hill Road, Palo Alto, CAView Profile , Polle T. Zellweger Information Sciences and Technologies Laboratory, Xerox PARC, 3333 Coyote Hill Road, Palo Alto, CA Information Sciences and Technologies Laboratory, Xerox PARC, 3333 Coyote Hill Road, Palo Alto, CAView Profile Authors Info & Claims ECHT '92: Proceedings of the ACM conference on HypertextNovember 1992 Pages 262–271https://doi.org/10.1145/168466.171513Published:01 December 1993Publication History 52citation499DownloadsMetricsTotal Citations52Total Downloads499Last 12 Months9Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Superconductor integrated circuit fabrication technology (2004)

Today's superconductor integrated circuit processes are capable of fabricating large digital logic chips with more than 10 K gates/cm/sup 2/. Recent advances in process technology have come from a variety of industrial foundries and university research efforts. These advances in processing have reduced critical current spreads and increased circuit speed, density, and yield. On-chip clock speeds of 60 GHz for complex digital logic and 750 GHz for a static divider (toggle flip-flop) have been demonstrated. Large digital logic circuits, with Josephson junction counts greater than 60 k, have also been fabricated using advanced foundry processes. Circuit yield is limited by defect density, not by parameter spreads. The present level of integration is limited largely by wiring and interconnect density and not by junction density. The addition of more wiring layers is key to the future development of this technology. We describe the process technologies and fabrication methodologies for digital superconductor integrated circuits and discuss the key developments required for the next generation of 100-GHz logic circuits.
The design of a platform for mobile data communication (2002)

Rapidly emerging new technologies in mobile radio and satellite communications are quickly reshaping applications in many sectors of the economy. However, the benefit of mobile communications technology in today's systems is often limited by the use of proprietary communication protocols and a tack of separation between the application and communication aspects. This paper describes an approach of how to overcome lacking portability and missing application independence by the design and implementation of an open systems platform for mobile communications. This is achieved by the utilization of widely accepted industry and/or international standards, in particular the Internet (TCP/IP) suite of protocols. Technical issues in the implementation of the platform on an existing packet radio network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Choose Your Label Wisely: Water-Soluble Fluorophores Often Interact with Lipid Bilayers (2014)

Water-soluble organic fluorophores are widely used as labels in biological systems. However, in many cases these fluorophores can interact strongly with lipid bilayers, influencing the interaction of the target with the bilayer and/or leading to misleading fluorescent signals. Here, we quantify the interaction of 32 common water-soluble dyes with model lipid bilayers to serve as an additional criterion when selecting a dye label.
Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensations (1999)

Cell surface adhesion and extracellular matrix proteins are known to play a key role in the formation of cell condensations during skeletal development, and their formation is crucial for the expression of cartilage-specific genes. However, little is known about the relationship between adhesion molecules (N-cadherin and N-CAM), extracellular matrix proteins (fibronectin and tenascin) and TGF-beta1, TGF-beta2 and TGF-beta3 during in vitro precartilage condensations in mouse chondrogenesis. On these bases, we determined the participation of mammalian TGF-beta1, TGF-beta2 and TFG-beta3 and Xenopus TGF-beta5 on the expression of cell surface adhesion and extracellular matrix proteins during the formation of precartilage condensations. Also, we characterized the effects of TGF-betas on proteoglycan metabolism at different cellular densities in mouse embryonic limb bud mesenchymal cells. In TGF-beta1 and TGF-beta5-treated cultures, proteoglycan biosynthesis was higher than in controls, while there were no differences in proteoglycan catabolism, which caused the accumulation of cartilage extracellular matrix. When mesenchymal cells were seeded at three different cellular densities in the presence of TGF-betas, only high density cultures presented increased stimulation of proteoglycan biosynthesis, compared to low and intermediate densities. To determine whether the effect of TGF-betas on precartilage condensations is mediated through the expression of N-cadherin, N-CAM, fibronectin and tenascin, we evaluated their expression. Results showed that TGF-beta1, TGF-beta2, TGF-beta3, and TGF-beta5 differentially enhanced the expression of N-cadherin, N-CAM, fibronectin and tenascin in precartilage condensations, suggesting that TGF-beta isoforms play an important role in the establishment of cell-cell and cell-extracellular matrix interactions during precartilage condensations.
Multifunctional CMOS Microchip Coatings for Protein and Peptide Arrays (2007)

Complementary metal oxide semiconductor (CMOS) microelectronic chips fulfill important functions in the field of biomedical research, ranging from the generation of high complexity DNA and protein arrays to the detection of specific interactions thereupon. Nevertheless, the issue of merging pure CMOS technology with a chemically stable surface modification which further resists interfering nonspecific protein adsorption has not been addressed yet. We present a novel surface coating for CMOS microchips based on poly(ethylene glycol)methacrylate graft polymer films, which in addition provides high loadings of functional groups for the linkage of probe molecules. The coated microchips were compatible with the harshest conditions emerging in microarray generating methods, thoroughly retaining structural integrity and microelectronic functionality. Nonspecific adsorption of proteins on the chip's surface was completely obviated even with complex serum protein mixtures. We could demonstrate the background-free antibody staining of immobilized probe molecules without using any blocking agents, encouraging further integration of CMOS technology in proteome research.
Coordination Chemistry ofN-Alkylbenzamide-2,3-dithiolates as an Approach to Poly(dithiolate) Ligands:  1,4-Bis[(2,3-dimercaptobenzamido)methyl]benzene and Its Chelate Complex with the (C5H5)Ti Fragment (1998)

The bidentate dithiolate ligands N,N-diethyl-2,3-dimercaptobenzamide (H(2)-1), bis(N,N-diethyl-2,3-dimercaptoterephthalamide (H(2)-2), and 1,4-bis(hydroxymethyl)-2,3-dimercaptobenzene (H(4)-3) were synthesized from 2,3-dimercaptobenzoic acid or 2,3-dimercaptoterephthalic acid. The air-sensitive ligands form metallocene complexes of the type [(eta(5)-C(5)H(5))(2)Ti(1)] (13), [(eta(5)-C(5)H(5))(2)Mo(1)] (15), [(eta(5)-C(5)H(5))(2)Ti(3)] (16), and [(eta(5)-C(5)H(5))(2)Ti(2)] (17). Complexes 15 and 16 were characterized by X-ray diffraction. Selected crystallographic details for 15 are as follows: formula C(21)H(23)MoNOS(2); M = 465.49; Pbca; a = 12.536(3), b = 14.313(3), c = 22.463(3) Å; V = 4031(2) Å(3); Z = 8; R = 3.56 and R(w) = 4.49 for 2111 structure factors (F(o)(2) >/= 3sigma(F(o)(2))) and 254 refined parameters. The molybdenum complex 15 shows an almost planar Mo(&mgr;-S)(2)C(2) chelate ring. Selected crystallographic details for 16 are as follows: formula C(18)H(18)O(2)S(2)Ti; M = 378.35; P&onemacr;; a = 10.1778(11), b = 11.5806(14), c = 22.967(3) Å; alpha = 96.42(1), beta = 101.74(1), gamma = 108.82(1) degrees; V = 2462.3(5) Å(3); Z = 6; R = 4.79 and R(w) = 13.27 for 5426 structure factors (I >/= 2sigma(I)) and 766 refined parameters. All titanocene derivatives assume the envelope conformation. The free activation energy for the flip around the S-S axis was determined for 13 to be 69 kJ/mol. The bis(dithiolate) ligand 1,4-bis[(2,3-dimercaptobenzamido)methyl]benzene (H(4)-4) was prepared from 2,3-dimercaptobenzoic acid and converted into the dinuclear air-stable titanocene complex [{(eta(5)-C(5)H(5))(2)Ti}(2)(4)] (19). Complex 19 reacts with HCl/CHCl(3) with liberation of free H(4)-4 while reaction with NMe(4)Cl results in an intramolecular dithiolate shift under formal liberation of [(C(5)H(5))(3)TiCl] and formation of the square-pyramidal chelate complex (NMe(4))[(eta(5)-C(5)H(5))Ti(4)], (NMe(4))[20]. Crystallographic details for (NMe(4))[20].CH(2)Cl(2) are as follows: formula C(32)H(35)Cl(2)N(3)O(2)S(4)Ti; M = 740.67; P&onemacr;; a = 11.579(4), b = 12.210(4), c = 14.016(4) Å; alpha = 112.28(2), beta = 94.46(3), gamma = 104.22(3) degrees; V = 1744.9(10) Å(3); Z = 2; R = 5.35 and R(w) = 12.84 for 2870 structure factors (I >/= 2sigma(I)) and 397 refined parameters. The chelate rings in [20](-) assume an endo/exo conformation.
In Vivo NGF Deprivation Reduces SNS Expression and TTX-R Sodium Currents in IB4-Negative DRG Neurons (1999)

Recent evidence suggests that changes in sodium channel expression and localization may be involved in some pathological pain syndromes. SNS, a tetrodotoxin-resistant (TTX-R) sodium channel, is preferentially expressed in small dorsal root ganglion (DRG) neurons, many of which are nociceptive. TTX-R sodium currents and SNS mRNA expression have been shown to be modulated by nerve growth factor (NGF) in vitro and in vivo. To determine whether SNS expression and TTX-R currents in DRG neurons are affected by reduced levels of systemic NGF, we immunized adult rats with NGF, which causes thermal hypoalgesia in rats with high antibody titers to NGF. DRG neurons cultured from rats with high antibody titers to NGF, which do not bind the isolectin IB4 (IB4(-)) but do express TrkA, were studied with whole cell patch-clamp and in situ hybridization. Mean TTX-R sodium current density was decreased from 504 +/- 77 pA/pF to 307 +/- 61 pA/pF in control versus NGF-deprived neurons, respectively. In comparison, the mean TTX-sensitive sodium current density was not significantly different between control and NGF-deprived neurons. Quantification of SNS mRNA hybridization signal showed a significant decrease in the signal in NGF-deprived neurons compared with the control neurons. The data suggest that NGF has a major role in the maintenance of steady-state levels of TTX-R sodium currents and SNS mRNA in IB4(-) DRG neurons in adult rats in vivo.
Ultralarge single crystal SnS rectangular nanosheets (2011)

Uniform ultralarge single crystal SnS rectangular nanosheets (7000 nm × 3000 nm × 20 nm) have been synthesized by thermodecomposing a single-source precursor (Sn-diethyldithiocarbamate-1,10-phenanthroline). The obtained SnS nanosheets exhibit excellent electrochemical properties which have promising applications in lithium ion batteries.
Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo (2005)

Nitric oxide (NO) inhibits myocardial glucose transport and metabolism, although the underlying mechanism(s) and functional consequences of this effect are not clearly understood. We tested the hypothesis that NO inhibits the activation of AMP-activated protein kinase (AMPK) and translocation of cardiac glucose transporters (GLUTs; GLUT-4) and reduces lactate production. Ischemia was induced in open-chest dogs by a 66% flow reduction in the left anterior descending coronary artery (LAD). During ischemia, dogs were untreated (control) or treated by direct LAD infusion of (i) nitroglycerin (NTG) (0.5 microg.kg(-1).min(-1)); (ii) 8-Br-cGMP (50 microg.kg(-1).min(-1)); or (iii) NO synthase inhibitor L-nitro-argininemethylester (40 microg.kg(-1).min(-1); n = 9 per group). Cardiac substrate oxidation was measured with isotopic tracers. There were no differences in myocardial blood flow or oxygen delivery among groups; however, at 45 min of ischemia, the activation of AMPK was significantly less in NTG (77 +/- 12% vs. nonischemic myocardium) and 8-Br-cGMP (104 +/- 13%), compared with control (167 +/- 17%). Similarly, GLUT-4 translocation was significantly reduced in NTG (74 +/- 7%) and 8-Br-cGMP (120 +/- 11%), compared with control (165 +/- 17%). Glucose uptake and lactate output were 30% and 60% lower in NTG compared with control. Inhibition of NO synthesis stimulated glucose oxidation (67% increase compared with control) but did not affect AMPK phosphorylation, GLUT-4 translocation and glucose uptake. Contractile function in the ischemic region was significantly improved by NTG and L-nitro-argininemethylester. In conclusion, in ischemic myocardium an NO donor inhibits glucose uptake and lactate production via a reduction in AMPK stimulation of GLUT-4 translocation, revealing a mechanism of metabolic modulation and myocardial protection activated by NO donors.
Synthesis of a new class of spin-labeled purine ribonucleosides and development of a novel nucleophilic reaction to form 2,6,8-trifunctionalized purine derivatives (2000)

Novel purine ribonucleosides with a tert-butylhydroxyamino function at the C8-position of the purine nucleus were synthesized, and were oxidized to aminoxyl radicals by treatment with Ag2O; after O-acylation of the tert-butylhydroxyamino group, nucleophilic substitution at the C2-position of the purine nucleus easily proceeded with elimination of the N-acyloxy group to provide a novel method for preparing C2-functionalized purine ribonucleosides.
Mécanismes, étiologie et classification nosologique (2001)

L'epilepsie est un ensemble d'affections chroniques caracterisees par la recurrence de manifestations paroxystiques liees a des decharges synchrones de populations de neurones. Les mecanismes et les causes n'en sont que partiellement connus car de rares types d'epilepsies ont un modele animal. Ils sont souvent polyfactoriels et les phenomenes de developpement cerebral conferent aux epilepsies de l'enfant de nombreuses particularites par rapport aux epilepsies de l'adulte.
Immune Complex-Mediated Enhancement of Antibody Responses without Induction of Delayed-Type Hypersensitivity (2000)

Immunoglobulin (Ig)G and IgE antibodies enhance the humoral response in vivo to soluble antigens with which they form complexes. In vitro, antigen is targeted to B cells by IgE antibodies and to macrophages and dendritic cells (DCs) by IgG, thus leading to increased antigen presentation to specific T cells. Possibly these mechanisms are also responsible for antibody-mediated enhancement in vivo. We now address the question of whether IgG- and/or IgE-antigen complexes can prime for delayed-type hypersensitivity (DTH), a reaction known to require primed T helper (Th)1 cells. Mice were immunized with IgG-anti-2,4,6-trinitrophenyl (TNP)/BSA-TNP or IgE-anti-TNP/BSA-TNP. Mice given BSA-TNP alone or BSA-TNP in complete Freund's adjuvans (CFA) were used as controls. DTH and IgG-anti-BSA levels were measured after subsequent challenge with BSA. A potent BSA-specific antibody response was induced by IgE- or IgG-complexed antigen as well as by CFA/antigen but DTH-reactions were only observed in mice immunized with CFA/antigen. Both IgE and IgG enhanced the production of BSA-specific IgG1, IgG2a and IgG2b, although the most pronounced enhancement was seen in the production of IgG1. These findings suggest that Th2 cells rather than Th1 cells are involved in the immune response to IgG- and IgE-immune complexes.
The practicality of text signatures for accelerating string searching (1982)

Abstract This paper studies the use of text signatures in string searching. Text signatures are a coded representation of a unit of text formed by hashing substrings into bit positions which are, in turn, set to one. Then instead of searching an entire line of text exhaustively, the text signature may be examined first to determine if complete processing is warranted. A hashing function which minimizes the number of collisions in a signature is described. Experimental results for two signature lengths with both a text file and a program file are given. Analyses of the results and the utility and application of the method conclude the discussion.
A numerical method for designing acoustic cloak with homogeneous metamaterials (2010)

Based on the form invariance of Helmholtz equation, we present a rhombic acoustic cloak constructed with homogeneous metamaterials. In free space, the proposed cloak can effectively conceal an object inside under a given incident direction. Another application, namely carpet cloak, was also demonstrated by full wave simulations. The proposed cloak provided great convenience in the fabrication process due to the spatially uniform of relative density and modulus tensors.
Differentiation and functions of glial cells : proceedings of a satellite meeting of the International Society for Neurochemistry held in Rome, Italy, April 19-21, 1989 (1990)

Partial table of contents: GLIOGENESIS AND GLIAL DIFFERENTIATION Gliogenesis in the Developing Human Fetal Brain (B. Choi) A New Developmental and Functional Classification of Oligodendrocytes (A. Espinosa de los Monteros, et al.) HORMONES AND FACTORS The Identity of Glia Maturation Factor (R. Lim) Partial Purification of a Serum Protein That Induces the Differentiation of Type-2 Astroglia (S. Levison & K. McCarthy) CELL INTERACTIONS Mutually Imposed Structural Changes in Plasma Membranes of Astroglia and Brain Endothelium (M. Brightman & J. Tao-Cheng) Structure and Function of the Perivascular Astrocytic Glia During the Blood-Brain Barrier Development (M. Bertossi, et al.) SURFACE MOLECULES AND SUBSTRATES Neural Cell Adhesion Molecules and Myelination (S. Bhatt & D. Silberberg) A Monoclonal Antibody Defining a New Glial Marker in Birds (P. Cameron-Curry, et al.) ELECTROPHYSIOLOGY AND CHANNELS Reassessment of Membrane Properties in a Classic Glial Preparation (B. Barres, et al.) Quisqualate-Induced Hyperpolarization in Primary Astrocytes Is Dependent on Internal Ca2+ (M. Enkvist, et al.) ASTROCYTE FUNCTIONS Regulation of Potassium Homeostasis by Glial Cells (L. Hertz) MYELINATION Studies on Myelin Assembly: Biosynthesis and In Vitro Expression of Po (D. D'Urso, et al.) GLIAL CELLS IN PATHOLOGY Human Fetal and Transformed Glial Cells Are Susceptible to HTLV-1 Infection (B. Caronti, et al.) Index.
Use of polymerase chain reaction to detect the expression of the Mr 70,000 heat shock genes in control or heat shock leukemic cells as correlated to their heat response. (1990)

The expression of the Mr 70,000 heat shock protein (HSP-70) in heat-resistant variants or heat-shocked cells has been correlated with development of thermal resistance. In these studies polymerase chain reaction (PCR) was used to detect low levels of HSP-70 mRNA present in control, unheated cells to investigate the possibility of predicting the intrinsic heat response in various leukemic cells. The expression of two human heat shock genes in control or heat-shocked cells was investigated. Synthetic primers and probes from the untranslated region of the two HSP-70 genes sequenced by Hunt and Morimoto (HSP-70A)(C. Hunt and R. I. Morimoto, Proc. Natl. Acad. Sci. USA, 82: 6455-6459, 1985) and Voellmy et al. (HSP-70B)(R. Voellmy et al., Proc. Natl. Acad. Sci. USA, 82: 4949-4953, 1985) were used in PCR reactions to follow expression in control or heat-shocked leukemic K562, KG-1, and HL-60 cells. The PCR results were correlated with heat response and patterns of protein synthesis in these cells. Results indicate that, among leukemic cells, K562 was much more resistant to killing by heat shock than either KG-1 or HL-60 cells. All control cells, however, expressed the HSP-70B gene. Of the three leukemic cells tested, K562 was the most heat resistant and constitutively expressed the HSP-70A mRNA and the heat-inducible HSP-70 protein. KG-1 and HL-60 cells did not express this gene in unheated cells. All heat-shocked cells expressed the HSP-70A mRNA and the heat-inducible HSP-70 protein. However, there was no significant increase in the mRNA level of the HSP-70B in heat-shocked leukemic cells as measured by PCR or the S1-nuclease protection assay. Other cells including normal human bone marrow and normal and tumorous tissues of the colon and breast all expressed both genes in control cells. Normal breast tissue expressed less mRNA for HSP-70B gene than the tumor tissue obtained from the same patient. In all studies the amplified beta-actin mRNA expression was used as an internal standard. These studies indicate that HSP-70B gene is expressed in all control leukemic cells. The expression of this gene did not seem to correlate with intrinsic heat resistance. The HSP-70A expression correlated with intrinsic and transient heat resistance. These studies also indicate that both HSP-70 genes in humans may be expressed in a variety of unheated normal and tumorous tissues more so than previously reported.
Refractory status epilepticus (2005)

Refractory status epilepticus, while a challenge to the intensivist, can be treated with drugs that are commonly used by intensivists. The cooperation of an interested electroencephalographer is vital.