gebhart/patrepeval huggingface dataset:
FC14 First-line Dacarbazine (DTIC) plus Bevacizumab (B) combination therapy in advanced melanoma (MM) patients (pts): a phase II study (2010)

Background Advanced melanoma patients have a poor prognosis (median survival-time of <9 months; 5-year survival-rate <5%). Neither of the 2 FDA-approved agents for the treatment of stage IV melanoma [Dacarbazine (DTIC) and Interleukin-2 (IL-2)] has resulted in an improved overall-survival, but a modest increase in tumour response-rate. Single-agent DTIC showed average response-rate of 10% and median response-duration of 5–6 months, being poly-chemotherapy never proven as superior to mono-chemotherapy. To improve such sober results, different DTIC-combinations have been proposed. Several melanoma in vitro models showed a transcriptional up-regulation of Vascular Endothelial Growth-Factor (VEGF) by DTIC, suggesting the combination of DTIC/anti-VEGF therapy as an intriguing exploiting path. Aim Clinical benefit, response evaluation and duration as well as safety and feasibility of the combination DTIC/Bevacizumab in a group of chemotherapy-naive advanced melanoma pts, within a phase II study. Patients and methods Between July 2006 – September 2009, 40 advanced melanoma patients underwent first-line chemotherapy as follows: DTIC (800 mg/mq q4w)+Bevacizumab (10 mg/kg q2w). Disease evaluation was performed at each access by physical examination and every 3 cycles by whole-body (wb) CT-scan, according to Recist criteria. Response rate, median TTP and safety were analyzed. Results 36/40 patients were evaluable at the analysis-time, with 4 screening failures because of brain metastasis detection at the pre-study wb CT-scan (3pts) and bleeding risk (1pt). Male/Female=23/13; with a median age of the whole group of 57 years (Male 60 yr; Female 47 yr). PS 0/1=32/4. 6/36 pts (16.6%) developed partial response (PR), 13/36 pts (36.1%) stable disease (SD ≥24w=10 pts, 25.6%). 17/36 pts (47.2%) developed progressive disease (PD), defined respectively as Recist-criteria progression at the first CT-scan evaluation (8pts) or earlier clinical progression (ePD; 9pts). PR pts were on average older (65.7 yrs; range 46.3–74.1) than both SD (57.2 yrs; range 33.1–78.5) and PD pts (51.4 yrs; range 31.6–76.3). Median TTP was 6 mo (95% CI 2.8–12.6). Stratifying by M1-stage, PD-pts mostly belonged to the M1c-group (10/16). Furthermore, exploratory data analysis interestingly shows 42.2% clinical benefit (defined as PR+SD≥24w) and 16.5 months (95% CI 5–31.5) median survival. The treatment was well tolerated (most common AEs (8/39): mild hypertension & mucositis easily controlled by symptomatic therapy). Three SAEs were reordered: 2 major cardiac events and 1 allergic reaction to Bevacizumab at the first administration. Conclusion Long-lasting response obtained in both SD and PR pts and mild side effects support DTIC/B as a promising combination in advanced MM pts. We are currently investigating whether the molecular pattern and gene profiling of each patient can predict responders vs non-responders to the DTIC/B combination.
Biocompatible Inkjet Printing Technique for Designed Seeding of Individual Living Cells (2005)

Inkjet printers are capable of printing at high resolution by ejecting extremely small ink drops. Established printing technology will be able to seed living cells, at micrometer resolution, in arrangements similar to biological tissues. We describe the use of a biocompatible inkjet head and our investigation of the feasibility of microseeding with living cells. Living cells are easily damaged by heat; therefore, we used an electrostatically driven inkjet system that was able to eject ink without generating significant heat. Bovine vascular endothelial cells were prepared and suspended in culture medium, and the cell suspension was used as "ink" and ejected onto culture disks. Microscopic observation showed that the endothelial cells were situated in the ejected dots in the medium, and that the number of cells in each dot was dependent on the concentration of the cell suspension and ejection frequency chosen. After the ejected cells were incubated for a few hours, they adhered to the culture disks. Using our non-heat-generating, electrostatically driven inkjet system, living cells were safely ejected onto culture disks. This microseeding technique with living cells has the potential to advance the field of tissue engineering.
Josephson current and noise at a superconductor/quantum-spin-Hall-insulator/superconductor junction (2009)

We study junctions between superconductors mediated by the edge states of a quantum-spin-Hall insulator. We show that such junctions exhibit a fractional Josephson effect, in which the current phase relation has a $4\ensuremath{\pi}$ rather than a $2\ensuremath{\pi}$ periodicity. This effect is a consequence of the conservation of fermion parity---the number of electron $\text{mod}\text{ }2$---in a superconducting junction and is closely related to the ${Z}_{2}$ topological structure of the quantum-spin-Hall insulator. Inelastic processes, which violate the conservation of fermion parity, lead to telegraph noise in the equilibrium supercurrent. We predict that the low-frequency noise due these processes diverges exponentially with temperature $T$ as $T\ensuremath{\rightarrow}0$. Possible experiments on HgCdTe quantum wells will be discussed.
Free-flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes (2006)

This paper describes a microfabricated free-flow electrophoresis device with integrated ion permeable membranes. In order to obtain continuous lanes of separated components an electrical field is applied perpendicular to the sample flow direction. This sample stream is sandwiched between two sheath flow streams, by hydrodynamic focusing. The separation chamber has two open side beds with inserted electrodes to allow ventilation of gas generated during electrolysis. To hydrodynamically isolate the separation compartment from the side electrodes, a photo-polymerizable monomer solution is exposed to UV light through a slit mask for in situ membrane formation. These so-called salt-bridges resist the pressure driven fluid, but allow ion transport to enable electrical connection. In earlier devices the same was achieved by using open side channel arrays. However, only a small fraction of the applied voltage was effectively utilized across the separation chamber during free-flow electrophoresis and free-flow isoelectric focusing. Furthermore, the spreading of the carrier ampholytes into the side channels resulted in a very restricted pH gradient inside the separation chamber. The chip presented here allows at least 10 times more efficient use of the applied potential and a nearly linear pH gradient from pH 3 to 10 during free-flow isoelectric focusing could be established. Furthermore, the application of hydrodynamic focusing in combination with free-flow electrophoresis can be used for guiding the separated components to specific chip outlets. As a demonstration, several standard fluorescent markers were separated and focused by free-flow zone electrophoresis and by free-flow isoelectric focusing employing a transversal voltage of up to 150 V across the separation chamber.
Rehabilitation of a Weir, Sluiceway, and Canal Headworks (1999)

This article describes the restoration of the Bai Thuong Project, a river diversion structure critical to agriculture, industry, transportation, and power generation in Vietnam. Rehabilitation of this structure was only one of several irrigation and flood protection rehabilitation projects in Vietnam funded by Asian Development Bank.
Prediction of outcome and severity of illness by analysis of the frequency distributions of cardiorespiratory variables (1977)

Despite the wide variety of illnesses and operations, we observed a common cardiorespiratory pattern of shock that was differenf for the survivors and nonsurvivors, although no one variable was capable of predicting outcome. Differences between the patterns of survivors and nonsurvivors were defined by range criteria and by cut-points operationally obtained from the frequency distributions of cardiorespiratory variables. The values of each of the 33 variables obtained, at times remote from therapy during each successive stage in the postoperative course, were used to predict survival and death in a series of 113 patients by the range and cut-point methods. An average of 13.5% of all the available variables gave a correct prediction by the range cirteria and 35% by the cut-point method. The mean percentage of Right--Wrong classifications throughout all stages for range and cut-point methods was 80 and 85%, respectively. Using the last available stage, the outcome was correctly predicted by the range criteria in 80% and by the cut point method in 88% of the patients. The high percentage of correct predictions suggests that these methods may provide a measure of the severity of acute illness as well as early warning of impending death.
Android Wireless Application Development Volume I: Android Essentials (2012)

Android Wireless Application Development has earned a reputation as the most useful real-world guide to building robust, commercial-grade Android apps. Now, authors Lauren Darcey and Shane Conder have systematically revised and updated this guide for the latest Android SDK 4.0. To accommodate their extensive new coverage, theyve split the book into two volumes. Volume I focuses on Android essentials, including setting up your development environment, understanding the application lifecycle, designing effective user interfaces, developing for diverse devices, and optimizing your mobile app development process--from design through publishing. Every chapter has been thoroughly updated for the newest APIs, tools, utilities, and hardware. All sample code has been overhauled and tested on leading devices from multiple companies, and many new examples have been added. Drawing on decades of in-the-trenches experience as professional mobile developers, Darcey and Conder provide valuable new best practices--including powerful techniques for constructing more portable apps. This new edition contains full chapters on Android manifest files, content providers, effective app design, and testing; an all-new chapter on tackling compatibility issues; coverage of todays most valuable new Android tools and utilities; and even more exclusive tips and tricks. An indispensable resource for every Android development team member.
First Long-Term Application of Squeezed States of Light in a Gravitational-Wave Observatory (2013)

We report on the first long-term application of squeezed vacuum states of light to improve the shot-noise-limited sensitivity of a gravitational-wave observatory. In particular, squeezed vacuum was applied to the German-British detector GEO 600 during a period of three months from June to August 2011, when GEO 600 was performing an observational run together with the French-Italian Virgo detector. In a second period, the squeezing application continued for about 11 months from November 2011 to October 2012. During this time, squeezed vacuum was applied for 90.2% (205.2 days total) of the time that science-quality data were acquired with GEO 600. A sensitivity increase from squeezed vacuum application was observed broadband above 400 Hz. The time average of gain in sensitivity was 26% (2.0 dB), determined in the frequency band from 3.7 to 4.0 kHz. This corresponds to a factor of 2 increase in the observed volume of the Universe for sources in the kHz region (e.g., supernovae, magnetars). We introduce three new techniques to enable the long-term application of squeezed light, and show that the glitch rate of the detector did not increase from squeezing application. Squeezed vacuum states of light have arrived as a permanent application, capable of increasing the astrophysical reach of gravitational-wave detectors.
Detecting nanoscale vibrations as signature of life (2014)

The existence of life in extreme conditions, in particular in extraterrestrial environments, is certainly one of the most intriguing scientific questions of our time. In this report, we demonstrate the use of an innovative nanoscale motion sensor in life-searching experiments in Earth-bound and interplanetary missions. This technique exploits the sensitivity of nanomechanical oscillators to transduce the small fluctuations that characterize living systems. The intensity of such movements is an indication of the viability of living specimens and conveys information related to their metabolic activity. Here, we show that the nanomotion detector can assess the viability of a vast range of biological specimens and that it could be the perfect complement to conventional chemical life-detection assays. Indeed, by combining chemical and dynamical measurements, we could achieve an unprecedented depth in the characterization of life in extreme and extraterrestrial environments.
Wear of the polyethylene of Harris-Galante acetabular components inserted without cement. (1995)

The amount and rate of linear wear of the polyethylene of eighty Harris-Galante acetabular components, implanted without cement during a primary or revision total hip replacement in seventy-two patients, were determined by a comparison of the thicknesses of the cup as measured on the initial and most recent follow-up radiographs. The measurements were corrected for magnification error by direct measurement of the diameter of the femoral head on each radiograph. The mean duration of follow-up was sixty-eight months (range, fifty-six to ninety-six months). Linear wear averaged 0.77 +/- 0.51 millimeter (range, zero to 1.83 millimeters) over-all, with a mean rate of 0.14 +/- 0.09 millimeter (range, zero to 0.35 millimeter) per year. An increased rate of wear per year correlated with a decreased age of the patient and with regular exercise, but there was no relationship with the weight or sex of the patient, the initial thickness of the polyethylene, or the angle of abduction of the cup.
Spatial Analysis of Field Experiments-An Extension to Two Dimensions (1991)

The one-dimensional spatial analysis procedure proposed by Gleeson and Cullis (1987, Biometrics 43, 277-288) is extended to two dimensions using the subclass of separable lattice processes to model the errors. Residual maximum likelihood estimation of the models is described and diagnostics for testing model adequacy are derived. Results from the analysis of 24 sets of uniformity data indicate the frequent need for a two-dimensional analysis even when the plot shape is highly rectangular. These results also indicate the potential gain from using a two-dimensional spatial analysis rather than a row + column analysis. An example is presented of the analysis of a field experiment on tobacco.
ASSOCIATION BETWEEN HIGH-RISK DISEASE LOCI AND RESPONSE TO ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT FOR WET AGE-RELATED MACULAR DEGENERATION (2011)

In our patient cohort, there was no statistically significant association between response to anti-VEGF therapy and the genotype in both positive-responder and negative-responder groups. Larger studies with more power are necessary to further determine whether a pharmacogenetic association exists between wet age-related macular degeneration and anti-VEGF therapy.
Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma (1990)

Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo. In a primate model of asthma, a monoclonal antibody to ICAM-1 attenuated airway eosinophilia and hyperresponsiveness. Thus, antagonism of ICAM-1 may provide a therapeutic approach to reducing airway inflammation, hyperresponsiveness, and asthma symptoms.
Thermotolerance Generated by Plant/Fungal Symbiosis (2002)

All plants studied in natural ecosystems are symbiotic with fungi (1), which obtain nutrients while either positively, negatively, or neutrally affecting host fitness (2). Plant adaptation to selective pressures is considered to be regulated by the plant genome (3). To test whether mutualistic fungi contribute to plant adaptation, we collected 200 Dichanthelium lanuginosum plants from geothermal soils at 10 sites in Lassen Volcanic (LVNP) and Yellowstone (YNP) National Parks. These soils have annual temperature fluctuations ranging from about 20° to 50°C (4).
Biocompatibility and Immunology in the Encapsulation of Islets of Langerhans (Bioartificial Pancreas) (1996)

Successful transplantation of encapsulated islets (bioartificial pancreas) would circumvent problems of islet availability and rejection in the treatment of insulin-dependent diabetes with biological organ replacement. Alginates are widely used as a hydrogel matrix or membrane for immunoprotected transplantation. A major problem in the use of diffusion-based devices is the biocompatibility of the material used. The foreign body reaction after implantation of empty microcapsules into different compartments in rats, dogs and pigs is evaluated in this article. However, biocompatibility of the bioartificial pancreas has three different aspects: reaction of the entrapped islet to the encapsulation technique and material; reaction of the recipient against the incorporated device ( = foreign body reaction); and finally the reaction of the recipient against the encapsulated islet ( = immunology of bioartificial pancreas). It is obvious from different experiments that even if foreign body reactions (reactions against material) are almost abolished the recipient may react against material released from the encapsulated islet. In conclusion, transplantation of encapsulated islets induces various morphological reactions (i.e. inflammation and fibrosis) as a result of a variety of donor and recipient related factors. Therefore, the use of an adequate animal model that reflects the human situation is essential for progress in the development of a bioartificial pancreas.
Smart Sight: a tourist assistant system (2003)

In this paper, we present our efforts towards developing an intelligent tourist system. The system is equipped with a unique combination of sensors and software. The hardware includes two computers, a GPS receiver, a lapel microphone plus an earphone, a video camera and a head-mounted display. This combination includes a multimodal interface to take advantage of speech and gesture input to provide assistance for a tourist. The software supports natural language processing, speech recognition, machine translation, handwriting recognition and multimodal fusion. A vision module is trained to locate and read written language, is able to adapt to to new environments, and is able to interpret intentions offered by the user such as a spoken clarification or pointing gesture. We illustrate the applications of the system using two examples.
The central role of Fas‐ligand cell signaling in inflammatory lung diseases (2004)

Following inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1 beta and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas-FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseases.
Synthesis, characterization, and crystal structure of the gadolinium(III) chelate of (1R,4R,7R)-.alpha.,.alpha.',.alpha.''-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3MA) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, and crystal structure of the gadolinium(III) chelate of (1R,4R,7R)-.alpha.,.alpha.',.alpha.''-trimethyl-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3MA)Sang I. Kang, Rama S. Ranganathan, John E. Emswiler, Krishan Kumar, Jack Z. Gougoutas, Mary F. Malley, and Michael F. TweedleCite this: Inorg. Chem. 1993, 32, 13, 2912–2918Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ic00065a019https://doi.org/10.1021/ic00065a019research-articleACS PublicationsRequest reuse permissionsArticle Views652Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts