gebhart/patrepeval huggingface dataset:
Natural Killer Cell Consolidation for Acute Myelogenous Leukemia: A Cell Therapy Ready for Prime Time? (2010)

body radiation therapy of non-small cell lung cancer. J Thorac Oncol 2:S115-S117, 2007 10. Timmerman R, Galvin J, Pass H, et al: RTOG 0618: A Phase II Trial of Stereotactic Body Radiation Therapy in the Treatment of Patients With Operable Stage I/II Non-Small Cell Lung Cancer. Philadelphia, PA, Radiation Therapy Oncology Group, 2007, p 67 11. Hurkmans CW, Cuijpers JP, Lagerwaard FJ, et al: Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: Report from the Quality Assurance Working Party of the randomised phase III ROSEL study. Radiat Oncol 4:1, 2009 12. Dawood O: M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife Radiosurgery for Operable Lung Cancer Patients. http://www.accuray. com/PressReleases.aspx?release 676 13. Grills IS, Mangona VS, Welsh R, et al: Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non–small-cell lung cancer. J Clin Oncol 28:928-935, 2010 14. Ginsberg RJ, Rubinstein LV: Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 60:615-622, 1995; discussion 622-623 15. Reed CE, Harpole DH, Posther KE, et al: Results of the American College of Surgeons Oncology Group Z0050 trial: The utility of positron emission tomography in staging potentially operable non-small cell lung cancer. J Thorac Cardiovasc Surg 126:1943-1951, 2003 16. Cerfolio RJ, Bryant AS: Survival of patients with true pathologic stage I non-small cell lung cancer. Ann Thorac Surg 88:917-922, 2009; discussion 922-923 17. Lee Y, Auh SL, Wang Y, et al: Therapeutic effects of ablative radiation on local tumor require CD8 T cells: Changing strategies for cancer treatment. Blood 114:589-595, 2009
Characterization of surface plasmon polariton pulse propagation on thin metallic films and two dimensional nanohole arrays (2005)

A variety of techniques, including spectral measurements, near-field, and time-resolved spatial heterodyne imaging technique are employed to investigate the properties of surface plasmon polaritons. Such techniques may prove useful for investigating the properties of SPP waves, and their interaction with the surrounding media, intended for a variety of applications, including various sensors and future plasmon based integrated devices.
LDPC Decoding with Limited-Precision Soft Information in Flash Memories (2012)

This paper investigates the application of low-density parity-check (LDPC) codes to Flash memories. Multiple cell reads with distinct word-line voltages provide limited-precision soft information for the LDPC decoder. The values of the word-line voltages (also called reference voltages) are optimized by maximizing the mutual information (MI) between the input and output of the multiple-read channel. Constraining the maximum mutual-information (MMI) quantization to enforce a constant-ratio constraint provides a significant simplification with no noticeable loss in performance. Our simulation results suggest that for a well-designed LDPC code, the quantization that maximizes the mutual information will also minimize the frame error rate. However, care must be taken to design the code to perform well in the quantized channel. An LDPC code designed for a full-precision Gaussian channel may perform poorly in the quantized setting. Our LDPC code designs provide an example where quantization increases the importance of absorbing sets thus changing how the LDPC code should be optimized. Simulation results show that small increases in precision enable the LDPC code to significantly outperform a BCH code with comparable rate and block length (but without the benefit of the soft information) over a range of frame error rates.
Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography (2010)

Computationally reconstructed interferometric synthetic aperture microscopy is coregistered with optical coherence tomography (OCT) focal plane data to provide quantitative cross validation with OCT. This is accomplished through a qualitative comparison of images and a quantitative analysis of the width of the point-spread function in simulation and experiment. The width of the ISAM point-spread function is seen to be independent of depth, in contrast to OCT.
SIMP (Single Instruction stream/Multiple instruction Pipelining): a novel high-speed single-processor architecture (1989)

SIMP is a novel multiple instruction-pipeline parallel architecture. It is targeted for enhancing the performance of SISD processors drastically by exploiting both temporal and spatial parallelisms, and for keeping program compatibility as well. Degree of performance enhancement achieved by SIMP depends on; i) how to supply multiple instructions continuously, and ii) how to resolve data and control dependencies effectively. We have devised the outstanding techniques for instruction fetch and dependency resolution. The instruction fetch mechanism employs unique schemes of; i) prefetching multiple instructions with the help of branch prediction, ii) squashing instructions selectively, and iii) providing multiple conditional modes as a result. The dependency resolution mechanism permits out-of-order execution of sequential instruction stream. Our out-of-order execution model is based on Tomasulo's algorithm which has been used in single instruction-pipeline processors. However, it is greatly extended and accommodated to multiple instruction pipelining with; i) detecting and identifying multiple dependencies simultaneously, ii) alleviating the effects of control dependencies with both eager execution and advance execution, and iii) ensuring a precise machine state against branches and interrupts. By taking advantage of these techniques, SIMP is one of the most promising architectures toward the coming generation of high-speed single processors.
On-line calibration of lossless current sensing (2004)

In this paper, we describe a lossless current sensing method with on-line calibration where an auxiliary switch and a precision sense resistor are connected in parallel with a main power switch to achieve accuracy comparable to the sense resistor method, together with the advantage of essentially no additional power loss. The proposed current-sensing circuit and the calibration methods are particularly well suited for digital controller implementations where the required control and calibration functions can be easily accomplished. Experimental results with a digitally controlled 1.5 V, 15 A synchronous buck converter demonstrate functionality of the on-line calibration approach, showing a significant improvement in accuracy over voltage sensing across the power MOSFET on-resistance.
Multiphoton excitation cross-sections of molecular fluorophores (1996)

Nonlinear excitation of fluorophores through molecular absorption of two or three near-infra-red photons from the tightly focused femtosecond pulses of a mode-locked laser offers the cellular biologist an unprecedented panoply of biomolecular indicators for microscopic imaging and cellular analysis. Measurements of the two-photon excitation spectra of 25 ultra-violet and visible absorbing fluorophores from 690 to 1050 nm reveal useful cross sections for near infra-red excitation, providing an artist's palette of emission markers, chemical indicators, and native cellular absorbers for living biological preparations. Measurements of three-photon fluorophore excitation spectra now suggest relatively benign wavelengths to excite deeper UV fluorophores. The inherent optical sectioning capabilities of focused nonlinear excitation provides three-dimensional resolution for imaging and avoids out-of-focus background. Measured nonlinear excitation spectra are described and implications to nonlinear microscopy for biological imaging are defined.
Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism (2013)

Progressive HIV infection is characterized by dysregulation of the intestinal immune barrier, translocation of immunostimulatory microbial products, and chronic systemic inflammation that is thought to drive progression of disease to AIDS. Elements of this pathologic process persist despite viral suppression during highly active antiretroviral therapy (HAART), and drivers of these phenomena remain poorly understood. Disrupted intestinal immunity can precipitate dysbiosis that induces chronic inflammation in the mucosa and periphery of mice. However, putative microbial drivers of HIV-associated immunopathology versus recovery have not been identified in humans. Using high-resolution bacterial community profiling, we identified a dysbiotic mucosal-adherent community enriched in Proteobacteria and depleted of Bacteroidia members that was associated with markers of mucosal immune disruption, T cell activation, and chronic inflammation in HIV-infected subjects. Furthermore, this dysbiosis was evident among HIV-infected subjects undergoing HAART, and the extent of dysbiosis correlated with activity of the kynurenine pathway of tryptophan catabolism and plasma concentrations of the inflammatory cytokine interleukin-6 (IL-6), two established markers of disease progression. Gut-resident bacteria with capacity to catabolize tryptophan through the kynurenine pathway were found to be enriched in HIV-infected subjects, strongly correlated with kynurenine levels in HIV-infected subjects, and capable of kynurenine production in vitro. These observations demonstrate a link between mucosal-adherent colonic bacteria and immunopathogenesis during progressive HIV infection that is apparent even in the setting of viral suppression during HAART. This link suggests that gut-resident microbial populations may influence intestinal homeostasis during HIV disease.
Collaborative planning, forecasting and replenishment: demand planning in supply chain management (2007)

Recognising the value of information sharing among supply chain partners, a growing number of firms have expressed keen interest in jointly forecasting customer demand and co-managing business functions. In particular, such interest sparked the rapid development and implementation of Collaborative Planning, Forecasting and Replenishment (CPFR) that was proven to be successful in minimising safety stocks, improving order fill rates, increasing sales, and reducing customer response time. Despite increasing popularity, key drivers for the successful development and implementation of CPFR have not been fully understood by practitioners and academicians alike. This paper unveils the invisible challenges and opportunities for adopting and implementing CPFR. Also, it provides an overview of CPFR in comparison to other alternative forecasting techniques such as agent-based forecasting and focus forecasting, while synthesising the past evolutions and future trends of CPFR in a supply chain setting.
Nonintrusive identification of electrical loads in a three-phase environment based on harmonic content (2002)

This paper describes a signature construction for identifying loads based upon harmonic content of the current measured at a metering socket. Data gathered from ten loads at a commercial site served to experimentally validate the signature construction. The repeatability of current harmonics was investigated during transients and steady-states of several single, split-phase, and three-phase loads monitored in isolation.
Vastly improved para preference in the nitration of halobenzenes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVastly improved para preference in the nitration of halobenzenesPierre Laszlo and Pascal PennetreauCite this: J. Org. Chem. 1987, 52, 12, 2407–2410Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/jo00388a014https://doi.org/10.1021/jo00388a014research-articleACS PublicationsRequest reuse permissionsArticle Views934Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Durable Alteration of the Colonic Microbiota by the Administration of Donor Fecal Flora (2010)

This study demonstrates a durable beneficial change in the patients' bacterial populations of the colon to represent those of the healthy donor's microbiota. Manipulation of the colonic microbiota to improve its protective and beneficial role represents a promising field of new therapeutic strategies for the treatment of gastrointestinal conditions.
Meeting lawful interception requirements for selected IP traffic offload and local IP access traffic (2013)

Cellular network operators are dealing with the increased data requirements of their customers by attempting to offload traffic from the mobile core network. The 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> Generation Partnership Project (3GPP) standards have defined several strategies that allow for offloading user traffic from the mobile core network. The 3GPP standards also define requirements for the mobile networks to support lawful interception of subscriber traffic. The current methods employed by mobile network operators to perform lawful interception are insufficient to support the traffic offload methods. This paper describes the current lawful interception landscape as well as the methods to perform traffic offload. It then proposes the architecture and methods that allow for traffic offload while satisfying law enforcement needs.
Immobilization of Olefin Metathesis Catalysts on Monolithic Sol-Gel: Practical, Efficient, and Easily Recyclable Catalysts for Organic and Combinatorial Synthesis (2001)

Glass-bound Ru-based catalysts! Ru-containing glass pellets (see picture) efficiently promote olefin metathesis reactions and are easily employed in syntheses of compound libraries. These robust catalysts are active in air and commercially available solvents, can be recycled up to 16 times, and removed from reaction mixtures with a simple pair of tweezers (minimal solvent waste).
IgM‐Induced Specific Antibody Responses: Direct Correlation between Responsiveness and Natural or Induced Recurrence of the Idiotype (1983)

The idiotype (Id) expressed on antibodies of the trinitrophenol (TNP)‐spccific BALB/c hybridoma TNP.11 is defined as a ‘nonrecurrent’ or private Id in BALB/c mice, whereas the analysis of splenic plaque‐forming cells (PFC) and circulating antibody in DBA/2 mice immunized with TNP antigens revealed that TNP.11 is a ‘recurrent’ Id in this strain. TNP.11 antibodies were characterized by their ability to induce an antigen‐independent anti‐TNP response in these two strains. Whereas this antibody was negative in BALB/c mice [18], a clearcut increase in splenic anti‐TNP PFC, preferentially expressing the TNP.11 Id, was observed in DBA/2 mice. This correlation between Id recurrency and ability to induce antigen‐independent responses was further probed in BALB/c mice repeatedly immunized with anti‐TNP.11 Id antibodies (Ab3). Such BALB/c mice express the TNP.11 Id in detactable amounts even without antigen challenge and respond with increased numbers of splenic anti‐TNP PFC to the injection of low amounts of TNP.11 antibody. These findings suggest that the ability of an antibody to induce antigen‐independent PFC responses is associated with the‘recurrency’, either natural or induced, of the antibody Id.
The webgraph framework I (2004)

Studying web graphs is often difficult due to their large size. Recently,several proposals have been published about various techniques that allow tostore a web graph in memory in a limited space, exploiting the inner redundancies of the web. The WebGraph framework is a suite of codes, algorithms and tools that aims at making it easy to manipulate large web graphs. This papers presents the compression techniques used in WebGraph, which are centred around referentiation and intervalisation (which in turn are dual to each other). WebGraph can compress the WebBase graph (118 Mnodes, 1 Glinks)in as little as 3.08 bits per link, and its transposed version in as littleas 2.89 bits per link.
Biology of Gastrointestinal Stromal Tumors (2004)

Once a poorly defined pathologic oddity, in recent years, gastrointestinal stromal tumor (GIST) has emerged as a distinct oncogenetic entity that is now center stage in clinical trials of kinase-targeted therapies. This review charts the rapid progress that has established GIST as a model for understanding the role of oncogenic kinase mutations in human tumorigenesis. Approximately 80% to 85% of GISTs harbor activating mutations of the KIT tyrosine kinase. In a series of 322 GISTs (including 140 previously published cases) studied by the authors in detail, mutations in the KIT gene occurred with decreasing frequency in exons 11 (66.1%), 9 (13%), 13 (1.2%), and 17 (0.6%). In the same series, a subset of tumors had mutations in the KIT-related kinase gene PDGF receptor alpha (PDGFRA), which occurred in either exon 18 (5.6%) or 12 (1.5%). The remainder of GISTs (12%) were wild type for both KIT and PDGFRA. Comparative studies of KIT-mutant, PDGFRA-mutant, and wild-type GISTs indicate that there are many similarities between these groups of tumors but also important differences. In particular, the responsiveness of GISTs to treatment with the kinase inhibitor imatinib varies substantially depending on the exonic location of the KIT or PDGFRA mutation. Given these differences, which have implications both for the diagnosis and treatment of GISTs, we propose a molecular-based classification of GIST. Recent studies of familial GIST, pediatric GIST, and variant forms of GIST related to Carney's triad and neurofibromatosis type 1 are discussed in relationship to this molecular classification. In addition, the role of mutation screening in KIT and PDGFRA as a diagnostic and prognostic aid is emphasized in this review.
Kinetics and mechanism of hydrolysis of a silicate triester, tris(2-methoxyethoxy)phenylsilane (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics and mechanism of hydrolysis of a silicate triester, tris(2-methoxyethoxy)phenylsilaneK. J. McNeil, J. A. DiCaprio, D. A. Walsh, and R. F. PrattCite this: J. Am. Chem. Soc. 1980, 102, 6, 1859–1865Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/ja00526a015https://doi.org/10.1021/ja00526a015research-articleACS PublicationsRequest reuse permissionsArticle Views689Altmetric-Citations92LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure and regulation of the gene for dGTP triphosphohydrolase from Escherichia coli. (1990)

Escherichia coli encodes an enzyme, deoxyguanosine triphosphate triphosphohydrolase (dGTPase, EC 3.1.5.1), that cleaves dGTP into deoxyguanosine and tripolyphosphate. An E. coli mutant, optA1, contains a 50-fold increased level of dGTPase and cannot support the growth of phage T7 defective in [corrected] gene 1.2, whose product is an inhibitor of dGTPase. The optA1 mutation maps to 3.6 min on the E. coli chromosome and is closely linked to dapD. We have isolated the gene encoding dGTPase (dgt) from wild-type E. coli and determined its nucleotide sequence. The dgt gene lies immediately upstream of htrA and 6 kilobases from dapD, in the same region as the optA1 mutation. The dgt structural gene is 1515 base pairs, encoding a protein of 59,315 daltons, in agreement with the size and N-terminal amino acid sequence of the purified protein. An E. coli strain containing a null allele has no detectable phenotype when grown at 30-42 degrees C in rich medium. A transition of C to T in a potential promoter of dgt is required for expression of the optA1 phenotype.
ChemInform Abstract: Synthesis, Antitumor and Antitubercular Evaluation of Certain New Xanthenone and Acridinone Analogues. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hexapus, a new complexing agent for organic molecules (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexapus, a new complexing agent for organic moleculesF. M. Menger, M. Takeshita, and J. F. ChowCite this: J. Am. Chem. Soc. 1981, 103, 19, 5938–5939Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/ja00409a067https://doi.org/10.1021/ja00409a067research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts