gebhart/patrepeval huggingface dataset:
Metabolic Profiling of CSF: Evidence That Early Intervention May Impact on Disease Progression and Outcome in Schizophrenia (2006)

Our findings suggest brain-specific alterations in glucoregulatory processes in the CSF of drug-naïve patients with first-onset schizophrenia, implying that these abnormalities are intrinsic to the disease, rather than a side effect of antipsychotic medication. Short-term treatment with atypical antipsychotic medication resulted in a normalization of the CSF disease signature in half the patients well before a clinical improvement would be expected. Furthermore, our results suggest that the initiation of antipsychotic treatment during a first psychotic episode may influence treatment response and/or outcome.
Tail-Enabled Spiraling Maneuver for Gliding Robotic Fish (2014)

Gliding robotic fish, a new type of underwater robot, combines both strengths of underwater gliders and robotic fish, featuring long operation duration and high maneuverability. In this paper, we present both analytical and experimental results on a novel gliding motion, tail-enabled three-dimensional (3D) spiraling, which is well suited for sampling a water column. A dynamic model of a gliding robotic fish with a deflected tail is first established. The equations for the relative equilibria corresponding to steady-state spiraling are derived and then solved recursively using Newton's method. The region of convergence for Newton's method is examined numerically. We then establish the local asymptotic stability of the computed equilibria through Jacobian analysis and further numerically explore the basins of attraction. Experiments have been conducted on a fish-shaped miniature underwater glider with a deflected tail, where a gliding-induced 3D spiraling maneuver is confirmed. Furthermore, consistent with model predictions, experimental results have shown that the achievable turning radius of the spiraling can be as small as less than 0.4 m, demonstrating the high maneuverability.
A chip-scale atomic clock based on ^87Rb with improved frequency stability (2005)

We demonstrate a microfabricated atomic clock physics package based on coherent population trapping (CPT) on the D1 line of 87Rb atoms. The package occupies a volume of 12 mm3 and requires 195 mW of power to operate at an ambient temperature of 200 degrees C. Compared to a previous microfabricated clock exciting the D2 transition in Cs [1], this 87Rb clock shows significantly improved short- and long-term stability. The instability at short times is 4 x?10-11 / tau?/2 and the improvement over the Cs device is due mainly to an increase in resonance amplitude. At longer times (tau?> 50 s), the improvement results from the reduction of a slow drift to ?5 x 10-9 / day. The drift is most likely caused by a chemical reaction of nitrogen and barium inside the cell. When probing the atoms on the D1 line, spin-exchange collisions between Rb atoms and optical pumping appear to have increased importance compared to the D2 line.
Method of control of nitrogen content in ZnO films: Structural and photoluminescence properties (2004)

In this article, nitrogen doped ZnO thin films with various nitrogen concentrations were obtained by thermal processing of zinc oxynitride alloy films prepared by radio frequency reactive magnetron sputtering. X-ray photoelectron spectroscopy study shows that varying the annealing temperature can modulate the concentration of nitrogen in ZnO. X-ray diffraction and Raman scattering measurements were employed to investigate the structural changes of ZnO films induced by the introduction of nitrogen. The results of the temperature-dependent photoluminescence measurements suggest that the optical properties of ZnO thin films are strongly influenced by nitrogen incorporation. With this technique, the binding energy of the nitrogen acceptor is also estimated.
Suppression of Liver Microsomal Drug-Metabolizing Enzyme Activities in Adult Female Rats Pretreated with Cannabidiol. (1993)

The suppression by cannabidiol (CBD) of the liver microsomal drug-metabolizing enzyme activities in female rats was demonstrated and its mechanism was examined. Pretreatment of rats with CBD (10 mg/kg, i.p.) caused temporary decreases in contents of cytochrome P450 (P450) and b5 and NADPH-cytochrome c (P450) reductase activity compared with values from the vehicle control group. p-Nitroanisole O-demethylase, aniline hydroxylase, d-benzphetamine N-demethylase and delta 9-tetrahydrocannabinol 11-hydroxylase were also decreased by the CBD pretreatment. The latter two activities took a longer time to return to control levels than the former two. However, the CBD pretreatment, which reduced the protein level of P450 UT-2 (CYP2C11) in adult male rats, did not decrease the protein level of P450 F-1 (CYP2C6) or F-2 (CYP2C12) in liver microsomes from female rats. These results suggest that the mechanisms by which CBD suppresses liver microsomal drug-metabolizing enzyme activities are different in male and female rats.
Characterization of Ocular Surface Epithelial and Progenitor Cell Markers in Human Adipose Stromal Cells Derived from Lipoaspirates (2011)

The expression of putative stem cell markers (CD90, ABCG2, and p63) and cytokeratins (CK12 and CK76) supports the hypothesis that ADS cells have self-renewal capacity and intrinsic plasticity that enables them to acquire some epithelial-like characteristics. Therefore, adult ADS cells could be a potential source for cell therapy in ocular surface regeneration.
UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors (2012)

The current study demonstrates associations between UBE4B expression and the outcomes of patients with neuroblastoma and between UBE4B and EGFR expression in neuroblastoma tumor samples. Moreover, levels of UBE4B influence neuroblastoma tumor cell proliferation, EGFR degradation, and response to EGFR inhibition. These results suggest UBE4B-mediated growth factor receptor trafficking may contribute to the poor prognosis of patients who have neuroblastoma tumors with 1p36 deletions and that UBE4B expression may be a marker that can predict responses of neuroblastoma tumors to treatment.
Surface-Induced Parallel Alignment of Liquid Crystals by Linearly Polymerized Photopolymers (1992)

Photopolymerization of polymer-coated solid substrates with linearly polarized light is shown to induce an anisotropic, uniaxial orientation of polymer molecules. The linearly photopolymerized (LPP) layers exhibit UV dichroism and optical anisotropy. The resulting anisotropic dispersive surface interaction forces are shown to align adjacent liquid crystals parallel. A qualitative microscopic model is presented. The new LPP-alignment technique allows to generate homogeneous LC-director pattern with different azimuthal director angles on the same substrate requiring no mechanical treatment. The use of LPP substrates in liquid crystal displays (LCDs) is shown to enable to combine different electrooptical effects-such as twisted nematic (TN) and parallel configurations-in the same hybrid LCD. Besides from high-contrast LPP-aligned TN-LCDs, LPP-aligned supertwisted nematic (STN)-LCDs exhibiting steep transmission-voltage characteristics are presented.
A statistical analysis of acoustic emission signals for tool condition monitoring (TCM) (2003)

The statistical properties of acoustic emission signals for tool condition monitoring (TCM) applications in mechanical lathe machining are analyzed in this paper. Time series data and root mean square (RMS) values at various tool wear levels are shown to exhibit features that can be put into relation with aging in both cases. In particular, the histograms of raw data show power-law distributions above a cross-over value, in which newer cutting tools exhibit more numerous larger events compared with more worn-out ones. For practical purposes, statistics based on RMS values are more feasible, and the analysis of these also reveals discriminating age-related features. The assumption that experimental RMS histograms follow a Beta (β) distribution has also been tested. The residuals of the modeling β functions indicate that the search for a more appropriate fitting function for the experimental distribution is desirable.
Chemistry of the Neomycins. V. Differentiation of the Neomycin Complex. Identity of Framycetin and Neomycin B. Compounds Obtained from Methyl Neobiosaminide B (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of the Neomycins. V. Differentiation of the Neomycin Complex. Identity of Framycetin and Neomycin B. Compounds Obtained from Methyl Neobiosaminide BKenneth L. Rinehart Jr., Alexander D. Argoudelis, William A. Goss, Arthur Sohler, and Carl P. SchaffnerCite this: J. Am. Chem. Soc. 1960, 82, 15, 3938–3946Publication Date (Print):August 1, 1960Publication History Published online1 May 2002Published inissue 1 August 1960https://pubs.acs.org/doi/10.1021/ja01500a037https://doi.org/10.1021/ja01500a037research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action (2019)

Probiotics have shown great promise in promoting human health. Despite the promising evidence, there is little information on the clinical efficacy of many of the available probiotics and their mechanisms of action are often unclear. Bifidobacterium longum subsp. longum BB536 is a clinically effective, well-established, multifunctional probiotic that has a long history of human use in alleviating gastrointestinal, immunological and infectious diseases. This review summarizes the functional benefits of BB536 from the most relevant clinical and animal studies and offers a theoretical basis for understanding its mechanisms of action. Key clinical findings point out that BB536 could act as a microbiome modulator to orchestrate the physiological activities of gut communities. Specifically, BB536 modulates luminal metabolism, stabilizes gut microbiota, and ultimately drives a fine-tuned homeostatic balance within the host-microbiome interaction. Clinical evidence of effectiveness of BB536 and how such multifunctional activities take place would be valuable for an optimized probiotic selection.
Tetrapeptide inhibitors of the IgA1 proteinases from type I Neisseria gonorrhoeae (1989)

The six series of unique tetrapeptides and their blocked N-acetyl, C-amide, and N-acetyl-C-amide analogues which comprise the hinge region of human IgA1 (Ser224 to Ser240) have been synthesized and tested as inhibitors of the type 1 IgA1 proteinase elaborated by Neisseria gonorrhoeae (EC 3.4.24.13). Most series had at least one member with an IC50 value less than 1 mM. The most effective inhibitors came from the series Ser-Thr-Pro-Pro (P4-P1) and Pro-Thr-Pro-Ser (P1-P3'). One member from each series had an IC50 value in the low microM range. Magnetic resonance studies (Siemion, I. Z.; et al. Biophys. Chem. 1988, 31, 35) indicate that the various tetrapeptide series appear to have different preferred solution conformations. However, these do not appear to be correlated with affinity for the neisserial proteinase. The most effective inhibitors tend to have a threonine residue adjacent to the N-terminus and the P1 or P1' residues at either the N- or the C-terminus. These relationships are not exclusive however, as other inhibitors, which do not meet these criteria, bind reasonably well. The most effective substrate analogues outlined here are about one-half the size and bind to the neisserial proteinase 2 orders of magnitude more tightly than previously reported inhibitors.
Contactless determination of current–voltage characteristics and minority-carrier lifetimes in semiconductors from quasi-steady-state photoconductance data (1996)

A simple method for implementing the steady-state photoconductance technique for determining the minority-carrier lifetime of semiconductor materials is presented. Using a contactless instrument, the photoconductance is measured in a quasi-steady-state mode during a long, slow varying light pulse. This permits the use of simple electronics and light sources. Despite its simplicity, the technique is capable of determining very low minority carrier lifetimes and is applicable to a wide range of semiconductor materials. In addition, by analyzing this quasi-steady-state photoconductance as a function of incident light intensity, implicit current–voltage characteristic curves can be obtained for noncontacted silicon wafers and solar cell precursors in an expedient manner.
Mining Customer Feedbacks for Actionable Intelligence (2010)

Mining consumer-generated text can provide business intelligence to organizations by extracting important knowledge trapped in the form of opinions, thoughts, and ideas expressed by their employees and customers on various aspects relevant to business. The key challenge here is to extract and organize relevant information from noisy text in order to effectively transform it to actionable intelligence. However, there is no formal framework to guide this analytical task. In this work, we present a system that is suitable for purpose-driven mining of free-text customer feedback to convert the knowledge gained to actionable intelligence.
The IEEE 802.11 universe (2010)

The introduction of IEEE's 802.11 standards has enabled a mass market, with a huge impact in the home, office, and public areas. Today, laptops, PCs, printers, cellular phones, VoIP phones, MP3 players, Blu-Ray players, and many more devices incorporate wireless LAN technology. With low-cost chipsets and support for high data rates, 802.11 has become a universal solution for an ever increasing application space. As a direct consequence of its high market penetration, several amendments to the basic 802.11 standard have been developed or are under development. They fix technology issues or add functionality expected to be required by future applications. In this article we overview the emerging 802.11 standard and address the technical context of its extensions. The article highlights its finalized amendments and those under development.
Protection against experimental nervous system autoimmune diseases by a human immunodeficiency virus-1 Tat peptide-based polyvalent vaccine (1996)

The human immunodeficiency virus-1 (HIV-1) Tat peptide is taken up by a variety of cells in vitro and in vivo (Anderson et al.: Biochem Biophys Res Commun 194:876-884, 1993; Fawell et al.: Proc Natl Acad Sci USA 91:664-668, 1994; Chen et al.: Anal Biochem 227:168-175, 1995). We have used Tat37-72, the fragment containing a domain binding to alpha v beta 5 integrin (Vogel et al.: J Cell Biol 121:461-468, 1993), to deliver a fusion protein of three pathogenic rat T-cell epitopes, MBP68-84, P2,53-78, and IRBP1169-1191 systemically and via mucoepithelial surfaces. This recombinant polyvalent vaccine peptide, toolbox101, is-depending on the route of administration-specifically immunosuppressive and can be used to vaccinate against experimental autoimmune encephalomyelitis, neuritis, and uveoretinitis and is, in addition, of therapeutic value.
Prognostic value of cancer stem cells, epithelial-mesenchymal transition and circulating tumor cells in lung cancer (2013)

The epithelial-mesenchymal transition (EMT) is a program involved in embryonic development that is often activated during cancer invasion and metastasis. CD133 is the main marker identifying cancer stem cells (CSCs) in lung cancer. Circulating tumor cells (CTCs) are demonstrated to be useful as a biomarker for the diagnosis and treatment of cancer. The aim of this study was to correlate EMT, CSCs and CTCs with patient prognosis to verify whether they can contribute to better stratification of lung cancer patients at risk for recurrent and metastatic disease. Pulmonary venous blood was drawn after major pulmonary surgery in 45 patients with resectable non-small cell lung cancer (NSCLC) in order to identify CTCs. For the same patients, we also constructed prognostic lung tissue microarrays (TMA) for CD133 and c-kit and evaluated CSC and EMT markers using flow cytometry. Cytokeratin-positive cells were detectable in 11 (23.9%) cases. c-kit expression was heterogeneous in prognostic TMAs while CD133 expression was low or absent which was also confirmed by flow cytometry and RT-PCR. Flow cytometric analysis showed that the mean percentage of cells with CD133 expression was 1.6%. CD90 and CD326 markers were co-expressed with a mean percentage of 10.41%. When CD133 and CD90/CD326 expression was correlated with follow-up, CD133 showed a higher correlation with deceased patients when compared with CD90/CD326 co-expression (32.5 vs. 9.5%). CD133 expression demonstrated a strong significant association with patients exhibiting progressive disease when compared to CD90/CD326 expression (15 vs. 7.1%). CD133 may be significantly associated with invasion and metastatic spread of NSCLC. The co-expression of CD90, CD326 and CD133 has definite prognostic value in patients with NSCLC.
DNA phosphorothioation is widespread and quantized in bacterial genomes (2011)

Phosphorothioate (PT) modification of DNA, with sulfur replacing a nonbridging phosphate oxygen, was recently discovered as a product of the dnd genes found in bacteria and archaea. Given our limited understanding of the biological function of PT modifications, including sequence context, genomic frequencies, and relationships to the diversity of dnd gene clusters, we undertook a quantitative study of PT modifications in prokaryotic genomes using a liquid chromatography-coupled tandem quadrupole mass spectrometry approach. The results revealed a diversity of unique PT sequence contexts and three discrete genomic frequencies in a wide range of bacteria. Metagenomic analyses of PT modifications revealed unique ecological distributions, and a phylogenetic comparison of dnd genes and PT sequence contexts strongly supports the horizontal transfer of dnd genes. These results are consistent with the involvement of PT modifications in a type of restriction-modification system with wide distribution in prokaryotes.
Introduction (1977)

lntro<luctim 'l11is ls the scconJ issue of Cliinas8 Sclen~, but the first devoted to subject rn.1t_tcr rather tlum to sci,olars.11,e iJUJugurnl issue was a Jircctory of ncnrly flfty people in Eurorc, /i.JJstrnlasi.a,nn<l the United Stntcs working in the primary sOJrccs o[ 01incsc science, tccJmo)CJ~Y, nnd mc<licine.A similar directory of sd1olnrs rcsicJent in Asia wUl appear i.n No. 3 or 4. Which it will be <lcpcnc.ison whether n.-Jrc time is nee<led to bri11g together the rcmni.ningmaleria]s for the directory, or to CCJTlflile the next grcup of studies that mecl the stan<l.1n.ls of Chinese Sc1011ce.
Sympathetic Nerve Activity in End-Stage Renal Disease (2002)

Despite correction of uremia, increased SNA is observed in renal transplant recipients with diseased native kidneys at a level not significantly different from chronic hemodialysis patients. The increased SNA seems to be mediated by signals arising in the native kidneys that are independent of circulating uremia related toxins.
A Polyethylene Glycol Copolymer for Carrying and Releasing Multiple Copies of Cysteine-Containing Peptides (1998)

Two different methods were developed to prepare an adduct of a poly(ethylene glycol)-lysine copolymer with either cysteamine or 1-amino-2-methyl-2-propanethiol. Cysteine-containing peptides could then be disulfide-linked to the thiol groups on the polymer in a facile manner. In the described procedures, a coupling ratio of about 8 peptides/molecule of poly(ethylene glycol)-lysine copolymer (Mw = 27 000) was typically attained. The products were stable at neutral pH, but the peptides could be released from the polymer in a physiologically relevant reducing environment. The release rate was highly dependent on the linker used for forming the disulfide bond. To illustrate the potential biomedical usefulness of this polymer carrier, a Tat peptide-PEG conjugate was shown to inhibit expression of a reporter gene fused to the TAR element of human immunodeficiency virus in a model cell assay.
The Hydrogen Economy (2004)

If the fuel cell is to become the modern steam engine, basic research must provide breakthroughs in understanding, materials, and design to make a hydrogen-based energy system a vibrant and competitive force
Hyaluronic acid enhances proliferation and chondroitin sulfate synthesis in cultured chondrocytes embedded in collagen gels (1999)

The effects of hyaluronic acid (HA) on the proliferation and chondroitin sulfate (CS) synthesis of chondrocytes embedded in collagen gels were examined. Articular cartilage was isolated from the humerus, femur, and tibia of 21 10-week-old Japanese white rabbits. Chondrocytes isolated by collagenase digestion were embedded in type I collagen gels and cultured in Dulbecco's modified Eagle's medium (DMEM) with various doses of HA for 4 weeks. Histological and biochemical evaluations were performed at postculture weeks 1, 2, 3, and 4. For biochemical evaluations, isomers such as chondroitin 6-sulfate (delta(di)-6S) and chondroitin 4-sulfate (delta(di)-4S) synthesized by cultured chondrocytes were determined by high performance liquid chromatography (HPLC) combined with fluorometry. Morphological and histological studies demonstrated that HA-treated chondrocytes in collagen gel proliferated profusely while maintaining their phenotype. At postculture week 4, 0.1 mg/ml of HA induced an eightfold increase in cell counts compared with HA pretreatment values, or 1.5-fold more than control group. Synthesis of delta(di)-6S (delta(di)-6S content/cell) in groups treated with 0.01 and 0.1 mg/ml of HA significantly increased, while gel accumulation rates in groups treated with 0.1 and 1.0 mg/ml of HA scored significantly higher values than other groups. In collagen gel culture, HA enhanced the proliferation and delta(di)-6S synthesis of chondrocytes while maintaining their phenotype. In clinical application, since the supply of autologous chondrocytes for transplantation is not unlimited, the HA-treated culture method may be useful for increasing the number of chondrocytes and thus improving the quality of implants.
Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia with Aminocaproic Acid (1994)

Hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease) is characterized by telangiectatic lesions of the nose, lips, and visceral organs including the liver, spleen, gastrointestinal tract, lungs, brain, and spinal cord1–5. It is inherited as an autosomal dominant trait. Its most common manifestations are recurrent epistaxis and gastrointestinal bleeding, which can be life threatening6. Nasal bleeding has been treated by dermatoplasty of the nasal septa, photocoagulation, and amniotic-membrane grafts6,7 and by the administration of estrogen and progesterone,8,9 but these treatments are often ineffective. Aminocaproic acid is a potent inhibitor of the fibrinolytic system. In low doses it blocks . . .