gebhart/patrepeval huggingface dataset:
Multiplication noise in uniform avalanche diodes (1966)

A general expression is derived from which the spectral density of the noise generated in a uniformly multiplying p-n junction can be calculated for any distribution of injected carriers. The analysis is limited to the white noise part of the noise spectrum only, and to diodes having large potential drops across the multiplying region of the depletion layer. It is shown for the special case in which <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\beta = k\alpha</tex> , where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</tex> is a constant and α and β are the ionization coefficients of electrons and holes, respectively, that the noise spectral density is given by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2eI_{in}M^{3}[1 + (\frac{1 - k}{k})(\frac{M - 1}{M})^{2}]</tex> where M is the current multiplication factor and I <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</inf> the injected current, if the only carriers injected into the depletion layer are holes, and by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2eI_{in}M^{3}[1 - (1 - k)(\frac{M - 1}{M})^{2}]</tex> if the only injected carriers are electrons. An expression is also derived for the noise power which will be delivered to an external load for the limit <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M \rightarrow \infin</tex> .
Some derivatives of nopinone (1970)

During other studies we required the conjugated ketone (I), which has been reported1 to be formed by collidine dehydrobromination of the 3,B-bromo ketone (2). Direct bromination of nopinone (3) gave (cf.2) a mixture of the 3P-and 3a-bromo ketones ( The formation and attempted dehydrobromination of each bromo ketone was therefore examined.
Early Detection Tools for Pancreatic Cancer (2012)

Finding pancreatic cancer while it’s still curable with surgery remains one of oncology’s most frustrating challenges. A growing pancreatic tumor can take more than 15 years to metastasize, during which patients generally aren’t symptomatic. When they finally experience abdominal pain, weight loss, and other hallmarks of the disease, it’s usually too late: Pancreatic cancer almost always kills within 2 years of diagnosis. But research funding for pancreatic cancer is up from $17.3 million in 1999 to $96.5 million today, according to the Pancreatic Cancer Action Network in Manhattan Beach, Calif. Meanwhile, researchers are making steady progress in early detection, focusing on blood biomarkers that might reveal the illness noninvasively and imaging tools that reveal potentially curable precursor lesions. Between them, imaging has made much bigger gains, according to Teri Brentnall, M.D., a gastroenterologist and professor at the University
A General Model for Selectivity in Olefin Cross Metathesis. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Kinetics and thermodynamics of oxygen and carbon monoxide binding to the T-state hemoglobin of Urechis caupo (1990)

The tetrameric hemoglobin from Urechis caupo is nearly ideal for studying ligation to the T-state. Our previous EXAFS study had shown that the Fe is displaced 0.35 A from the mean plane of the porphyrin in the HbCO derivative. We have carried out detailed kinetic studies of oxygen and CO ligation as a function of temperature in order to characterize both the kinetics and thermodynamics of ligation in this hemoglobin. The entropy change associated with ligation essentially corresponds to simple immobilization of the ligand and is virtually the same as that we have determined for leghemoglobin, an extreme R-state-type hemoglobin. The low ligand affinities thus derive from small enthalpies of ligation, which can be correlated with the large out of plane displacement of the Fe. Only oxygen pulse measurements revealed kinetic evidence for cooperative oxygen binding, but a direct measurement of oxygen binding gave a Hill number of 1.3. An allosteric analysis gave L = 2.6 and c = 0.048 (oxygen) and c = 0.77 (CO). The higher affinity state in this weakly cooperative hemoglobin is denoted T*, and it is for this state that thermodynamic quantities have been determined. The small differences between T and T* in CO binding were nevertheless sufficient to allow us to measure by flash photolysis the rate of the T*----T conformational change in terms of an allosteric model. The half-time for this transition was calculated to be 8-14 ms at 20 degrees C.
Implementing a distributed firewall (2000)

Conventional firewalls rely on topology restrictions and controlled network entry points to enforce traffic filtering. Furthermore, a firewall cannot filter traffic it does not see, so, effectively, everyone on the protected side is trusted. While this model has worked well for small to medium size networks, networking trends such as increased connectivity, higher line speeds, extranets, and telecommuting threaten to make it obsolete. To address the shortcomings of traditional firewalls, the concept of a "distributed firewall" has been proposed. In this scheme, security policy is still centrally defined, but enforcement is left up to the individual endpoints. IPsec may be used to distribute credentials that express parts of the overall network policy. Alternately, these credentials may be obtained through out-of-band means. In this paper, we present the design and implementation of a distributed firewall using the KeyNote trust management system to specify, distribute, and resolve policy, and OpenBSD, an open source UNIX operating system.
Precise excision and instability of the transposon Tn5 in Pseudomonas aeruginosa (1990)

Excision of the transposon Tn5 from sites of insertion in plasmid DNA was shown to occur at high frequency in Pseudomonas aeruginosa. Plasmids with Tn5 insertions conjugated poorly into P. aeruginosa and adversely affected growth compared to the respective parental plasmids. The kanamycin-resistance phenotype of Tn5 was expressed poorly in P. aeruginosa and kanamycin-sensitive strains were common during the manipulation of the P. aeruginosa transconjugants. Examination of plasmid DNA isolated from kanamycin-sensitive P. aeruginosa transconjugants revealed excision of Tn5 sequences. A plasmid containing a selectable marker (mercury resistance) inactivated by a Tn5 insertion was constructed, and Tn5 excised precisely, permitting the expression of the mercury-resistance marker at high frequency (10(-3) in P. aeruginosa and at the expected low frequency (10(-7] in Escherichia coli. The recombinational mechanism that promotes frequent Tn5 excision in P. aeruginosa operated in the absence of the P. aeruginosa recA gene product. Fragments of Tn5 were also examined for excision and instability in P. aeruginosa. A plasmid containing the terminal 485 bp of inverted repeat sequences from Tn5, but lacking the transposase or kanamycin-resistance genes, also showed precise excision of Tn5 DNA at high frequency (10(-2] in P. aeruginosa. Unlike plasmids containing a complete Tn5 insertion, this plasmid transferred to P. aeruginosa at normal frequencies and growth of the host was not severely impaired. In contrast, plasmids containing either IS50 element transferred to P. aeruginosa at greatly reduced frequencies, and transconjugants containing the IS50R element (which contains the active transposase gene) were small and especially difficult to maintain. P. aeruginosa transconjugants harbouring a plasmid containing only the DNA between the IS50 elements (which included the kanamycin-resistance gene) were of normal size and stably maintained.(ABSTRACT TRUNCATED AT 250 WORDS)
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri (2000)

Bacteria of Shigella spp. are the causative agents of shigellosis. The virulence traits of these pathogens include their ability to enter into epithelial cells and induce apoptosis in macrophages. Expression of these functions requires the Mxi-Spa type III secretion apparatus and the secreted IpaA-D proteins, all of which are encoded by a virulence plasmid. In wild-type strains, the activity of the secretion apparatus is tightly regulated and induced upon contact of bacteria with epithelial cells. To investigate the repertoire of proteins secreted by Shigella flexneri in conditions of active secretion, we determined the N-terminal sequence of 14 proteins that are secreted by a mutant in which secretion was deregulated. Sequencing of the virulence plasmid pWR100 of the S. flexneri strain M90T (serotype 5) has allowed us to identify the genes encoding these secreted proteins and suggests that approximately 25 proteins are secreted by the type III secretion apparatus. Analysis of the G+C content and the relative positions of genes and open reading frames carried by the plasmid, together with information concerning the localization and function of encoded proteins, suggests that pWR100 contains blocks of genes of various origins, some of which were initially carried by four different plasmids.
Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis (2011)

Enhancing the maturity of the newly formed blood vessels is critical for the success of therapeutic angiogenesis. The maturation of vasculature relies on active participation of mural cells to stabilize endothelium and a basal level of relevant growth factors. We set out to design and successfully achieved robust angiogenesis using an injectable polyvalent coacervate of a polycation, heparin, and fibroblast growth factor-2 (FGF2). FGF2 was loaded into the coacervate at nearly 100% efficiency. In vitro assays demonstrated that the matrix protected FGF2 from proteolytic degradations. FGF2 released from the coacervate was more effective in the differentiation of endothelial cells and chemotaxis of pericytes than free FGF2. One injection of 500 ng of FGF2 in the coacervate elicited comprehensive angiogenesis in vivo. The number of endothelial and mural cells increased significantly, and the local tissue contained more and larger blood vessels with increased circulation. Mural cells actively participated during the whole angiogenic process: Within 7 d of the injection, pericytes were recruited to close proximity of the endothelial cells. Mature vasculature stabilized by vascular smooth muscle cells persisted till at least 4 wk. On the other hand, bolus injection of an identical amount of free FGF2 induced weak angiogenic responses. These results demonstrate the potential of polyvalent coacervate as a new controlled delivery platform.
Indole induces the expression of multidrug exporter genes in Escherichia coli (2005)

Our comprehensive expression cloning studies previously revealed that 20 intrinsic xenobiotic exporter systems are encoded in the Escherichia coli chromosome, but most of them are not expressed under normal conditions. In this study, we investigated the compounds that induce the expression of these xenobiotic exporter genes, and found that indole induces a variety of xenobiotic exporter genes including acrD, acrE, cusB, emrK, mdtA, mdtE and yceL. Indole treatment of E. coli cells confers rhodamine 6G and SDS resistance through the induction of mdtEF and acrD gene expression respectively. The induction of mdtE by indole is independent of the EvgSA two-component signal transduction system that regulates the mdtE gene, but mediated by GadX. On the other hand, the induction of acrD and mdtA was mediated by BaeSR and CpxAR, two-component systems. Interestingly, CpxAR system-mediated induction required intrinsic baeSR genes, whereas BaeSR-mediated induction was observed in the cpxAR gene-deletion mutant. BaeR and CpxR directly bound to different sequences of the acrD and mdtA promoter regions. These observations indicate that BaeR is a primary regulator, and CpxR enhances the effect of BaeR.
Distinct Genetic Risk Based on Association of MET in Families With Co-occurring Autism and Gastrointestinal Conditions (2009)

These results suggest that disrupted MET signaling may contribute to increased risk for autism spectrum disorder that includes familial gastrointestinal dysfunction.
Targeted infection of a retrovirus bearing a CD4-Env chimera into human cells expressing human immunodeficiency virus type 1 (1995)

We constructed a hybrid Moloney murine leukaemia virus (MoMLV) bearing both a chimeric CD4 and the wild-type MoMLV envelope protein (Env) on its surface. The chimeric molecule, consisting of a surface domain of CD4 and the C-terminal two-thirds of MLV Env, was expressed on the cell surface. When expressed in MoMLV-infected cells, the CD4-Env chimera was incorporated into the virion as efficiently as the wild-type MoMLV Env. The hybrid MoMLV could infect human HeLa cells (although not with high efficiency) only if the cells were expressing human immunodeficiency virus type 1 genome. This method of ligand incorporation into a virion may lead to a development of a cell-specific retroviral vector for targeting gene therapy.
A brief survey of machine learning methods and their sensor and IoT applications (2017)

This paper provides a brief survey of the basic concepts and algorithms used for Machine Learning and its applications. We begin with a broader definition of machine learning and then introduce various learning modalities including supervised and unsupervised methods and deep learning paradigms. In the rest of the paper, we discuss applications of machine learning algorithms in various fields including pattern recognition, sensor networks, anomaly detection, Internet of Things (IoT) and health monitoring. In the final sections, we present some of the software tools and an extensive bibliography.
Management of sexually acquired reactive arthritis in 19 North Thames GUM clinics (2004)

Our objective was to describe how genitourinary medicine (GUM) clinics in the North Thames region manage sexually acquired reactive arthritis (SARA), and to compare management with national guidelines. A self-completed questionnaire survey and retrospective case note review was conducted between September and October 2001. Clinicians in 33 clinics were asked to describe their clinic's policy on the management of SARA, and to review the last five cases seen or the last cases seen in the preceding two years, if less than five. Nineteen (58%) clinics took part. There were inter-clinic variations in the investigation and management of patients, with only 63% (12/19) of clinics offering non-steroidal anti-inflammatory drugs (NSAIDs) and 58% (11/19) giving doxycycline 1001mg. twice daily for two weeks for urethritis - the rest using any of three other antibiotic regimens. There was no consistent policy of referral between other specialties and GUM for genital screening and partner notification. A total of 36 male and female case notes were reviewed. Patients without arthritis or joint swelling (5/38, 13%), or with non-typical symptoms such as diarrhoea (5/38, 13%) were diagnosed inappropriately with SARA. Only 33 (87%) had evidence of a sexually transmitted infection (STI) with at least two (5%) of patients being treated with antibiotics despite no apparent indication being present. Only 21 (55%) had documented NSAID therapy. Case identification was difficult due to the lack of a national disease code (KC60) for SARA. The data suggest that a diagnosis of SARA is sometimes being made with no identifiable STI, or where symptoms are more suggestive that another route of infection is likely. A clear guideline within clinics to standardize prescribing of antibiotics is needed and collaborative policies with GUM are needed for other specialties to use when investigating and managing patients with seronegative arthritis. GUM should consider re-introducing a KC60 code for SARA for better case identification.
Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease (2016)

Klotho/FGF23 may not only be diagnostic and/or prognostic biomarkers for CKD and CVD, but are also pathogenic contributors to CKD progression and CVD development. The Klotho/FGF23 axis should be a novel target for renal clinics.
UV photopatterning of alkanethiolate monolayers self-assembled on gold and silver (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUV photopatterning of alkanethiolate monolayers self-assembled on gold and silverMichael J. Tarlov, Donald R. F. Burgess Jr., and Greg GillenCite this: J. Am. Chem. Soc. 1993, 115, 12, 5305–5306Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00065a056https://doi.org/10.1021/ja00065a056research-articleACS PublicationsRequest reuse permissionsArticle Views1334Altmetric-Citations325LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hard and Soft Acids and Bases (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHard and Soft Acids and BasesRalph G. PearsonCite this: J. Am. Chem. Soc. 1963, 85, 22, 3533–3539Publication Date (Print):November 1, 1963Publication History Published online1 May 2002Published inissue 1 November 1963https://pubs.acs.org/doi/10.1021/ja00905a001https://doi.org/10.1021/ja00905a001research-articleACS PublicationsRequest reuse permissionsArticle Views28682Altmetric-Citations7890LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural colouration of avian skin: convergent evolution of coherently scattering dermal collagen arrays (2003)

Structural colours of avian skin have long been hypothesized to be produced by incoherent (Rayleigh/Tyndall) scattering. We investigated the colour, anatomy, nanostructure and biophysics of structurally coloured skin, ramphotheca and podotheca from 31 species of birds from 17 families in 10 orders from across Aves. Integumentary structural colours of birds include ultraviolet, dark blue, light blue, green and yellow hues. The discrete peaks in reflectance spectra do not conform to the inverse fourth power relationship predicted by Rayleigh scattering. The dermis of structurally coloured skin consists of a thick (100-500 micro m) layer of collagen that is usually underlain by a layer of melanin granules. Transmission electron micrographs (TEMs) of this colour-producing dermal collagen layer revealed quasi-ordered arrays of parallel collagen fibres. Two-dimensional (2-D) Fourier analysis of TEMs of the collagen arrays revealed a ring of peak spatial frequencies in the spatial variation in refractive index that are the appropriate size to make the observed ultraviolet-yellow colours by coherent scattering alone. One species, Philepitta castanea (Eurylaimidae), has exceptionally ordered, hexagonal arrays of collagen fibres that produce a hexagonal pattern of spatial frequency peaks in the power spectra. Ultraviolet, blue, green and yellow structural colours of avian skin are produced by coherent scattering (i.e. constructive interference) by arrays of collagen fibres in the dermis. Some yellow and orange skin colours are produced with a combination of structural and pigmentary mechanisms. These combined colours can have reflectance spectra with discrete peaks that are more saturated than hues produced by carotenoid pigments alone. Bluish facial skin from two species of Neotropical antbirds (Thamnophilidae) are nanostructurally too small to produce visible light by coherent scattering, and the colour production mechanism in these species remains unknown. Based on the phylogenetic distribution of structurally coloured skin in Aves, this mechanism of colour production has evolved convergently more than 50 independent times within extant birds.
Virus inactivation by copper or iron ions alone and in the presence of peroxide (1993)

Cupric and ferric ions were able to inactivate five enveloped or nonenveloped, single- or double-stranded DNA or RNA viruses. The virucidal effect of these metals was enhanced by the addition of peroxide, particularly for copper(II). Under the conditions of our test, mixtures of copper(II) ions and peroxide were more efficient than glutaraldehyde in inactivating phi X174, T7, phi 6, Junin, and herpes simplex viruses. The substances described here should be able to inactivate most, if not all, viruses that have been found contaminating medical devices.
Activation of Nuclear Factor-κB in Cultured Endothelial Cells by Increased Glucose Concentration: Prevention by Calphostin C (1997)

Nuclear factor kappaB (NFkappaB) plays a pivotal role in early gene responses by promoting messenger RNA (mRNA) synthesis for various cell-adhesion molecules and inducible nitric oxide synthase. In this study, we examined whether increases in glucose concentration enhance NFkappaB expression in nuclear fractions of endothelial cells by using electrophoretic mobility shift assay. Bovine aortic endothelial cells (BAECs) were incubated in media containing 5.5-35 mM glucose. NFkappaB activity was increased as early as 1 h (peak activation at 2-4 h) after incubation with 35 mM glucose compared with 5.5 mM. Similar increases at 2 h of incubation were observed by using 25 but not 15 mM glucose. Glucose-induced NFkappaB activation was blocked by inhibiting nuclear translocation by using a peptide (SN-50) containing the nuclear-localization sequence of NFkappaB p50 linked to a membrane-permeable motif of the sequence for Kaposi fibroblast growth factor. Co-incubation with a selective protein kinase C (PKC) inhibitor, calphostin C, produced a concentration-dependent inhibition of glucose-induced NFkappaB activation. Thus NFkappaB activation is an early event in response to elevations in glucose, which may elicit multiple pathways contributing to the origin of hyperglycemia- or diabetes-induced endothelial cell injury.