gebhart/patrepeval huggingface dataset:
Investigation of Low Profile Antenna Designs for Use in Hand-Held Radios (1997)

Antennas in hand-held radios must be compact and unobtrusive. Electrically small and low-profile antennas experience high input reactance, low input resistance, and low radiation efficiency.Further degradation of radiation efficiency occurs in hand-held radios due to size-reduced ground planes, losses within the plastic device casing, and losses due to coupling with the tissue of the user. These factors may also affect the radiation pattern of the antenna. This discussion reports on antenna designs that are well suited for hand-held radios. The design issues are covered for electrically small antennas and the hand-held environment. A review of Microstrip Antenna (MSA) theory, and the theory of the Inverted-L Antenna (ILA), and variations on the ILA including the Inverted-F Antenna (IFA), Planar Inverted-F Antenna (PIFA), and Dual Inverted-F Antenna (DIFA) is included. Two specific antenna designs are presented: the DIFA and the Proximity-Coupled Rectangular Patch MSA. The radiation patterns and input impedance of the DIFA are calculated numerically and measured empirically. The Proximity-Coupled Rectangular Patch Microstrip Antenna is treated numerically.
Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor (2009)

Dimerization is recognized as a crucial step in the activation of many plasma membrane receptors. However, a growing number of receptors pre-exist as dimers in the absence of ligand, indicating that, although necessary, dimerization is not always sufficient for signaling. The p75 neurotrophin receptor (p75(NTR)) forms disulfide-linked dimers at the cell surface independently of ligand binding through Cys257 in its transmembrane domain. Here, we show that crosslinking of p75(NTR) dimers by cysteine-scanning mutagenesis results in constitutive, ligand-independent activity in several pathways that are normally engaged upon neurotrophin stimulation of native receptors. The activity profiles of different disulfide-crosslinked p75(NTR) mutants were similar but not identical, suggesting that different configurations of p75(NTR) dimers might be endowed with different functions. Interestingly, crosslinked p75(NTR) mutants did not mimic the effects of the myelin inhibitors Nogo or MAG, suggesting the existence of ligand-specific activation mechanisms. Together, these results support a conformational model of p75(NTR) activation by neurotrophins, and reveal a genetic approach to generate gain-of-function receptor variants with distinct functional profiles.
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction (2002)

The tumor necrosis factor (TNF) receptor associated factors (TRAFs) have emerged as the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAFs collectively play important functions in both adaptive and innate immunity. Recent functional and structural studies have revealed the individuality of each of the mammalian TRAFs and advanced our understanding of the underlying molecular mechanisms. Here, we examine this functional divergence among TRAFs from a perspective of both upstream and downstream TRAF signal transduction pathways and of signaling-dependent regulation of TRAF trafficking. We raise additional questions and propose hypotheses regarding the molecular basis of TRAF signaling specificity.
Synthesis of a hexyl methacrylate‐terminated disaccharide monomer and study of its radically initiated homo‐ and copolymerization with styrene (1993)

Abstract A new disaccharide monomer, 6(‐methacryloxyloxy)hexyl β‐D‐cellobioside (CHMA, 7h ), was prepared through a five‐step procedure (starting from cellobiose), in which the glycosylation and esterification reactions have been optimized. Kinetics of radical homopolymerization in dimethyl sulfoxide solution were studied through 1 H NMR, allowing the determination of the parameter k p / k t 1/2 . Copolymerizations with styrene (S) were also investigated, giving the reactivity ratios r S = 0,64 and r M = 0,08. Characterization of the various (co)polymers in terms of composition, microstructure and molecular weight was carried out using 1 H and 13 C NMR spectroscopy and gel‐permeation chromatography in tetrahydrofuran, respectively. A preferential syndiotactic configuration was clearly evidenced in the homopolymer.
Explaining odds ratios. (2010)

An odds ratio (OR) is a measure of association between an exposure and an outcome. The OR represents the odds that an outcome will occur given a particular exposure, compared to the odds of the outcome occurring in the absence of that exposure. Odds ratios are most commonly used in case-control studies, however they can also be used in cross-sectional and cohort study designs as well (with some modifications and/or assumptions). Odds ratios and logistic regression When a logistic regression is calculated, the regression coefficient (b1) is the estimated increase in the log odds of the outcome per unit increase in the value of the exposure. In other words, the exponential function of the regression coefficient (e b1 ) is the odds ratio associated with a one-unit increase in the exposure.
Generation of Dicke States with Phonon-Mediated Multilevel Stimulated Raman Adiabatic Passage (2012)

We generate half-excited symmetric Dicke states of two and four ions. We use multilevel stimulated Raman adiabatic passage whose intermediate states are phonon Fock states. This process corresponds to the spin squeezing operation and half-excited Dicke states are generated during multilevel stimulated Raman adiabatic passage. This method does not require local access for each ion or the preparation of phonon Fock states. Furthermore, it is robust since it is an adiabatic process. We evaluate the Dicke state using a witness operator and determine the upper and lower bounds of the fidelity without using full quantum tomography.
Ultrawideband Transceiver Design Using Channel Phase Precoding (2007)

A novel transceiver design for ultrawideband (UWB) communication systems using the channel phase precoding (CPP) technique is proposed in this work. With the CPP-UWB transceiver, we encode data symbols using the reversed order of the channel phase. A simple phase estimation algorithm is presented for the CPP-UWB implementation. Owing to its ability to coherently combine the channel magnitude of every multipath, the CPP-UWB transceiver can achieve a higher data rate by shortening its symbol duration with a tolerable interference. The performance of the CPP-UWB can be further improved using an optimal code length and/or the MMSE receiver to suppress intersymbol interference.
Antibacterial-ResistantPseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms (2009)

Treatment of infectious diseases becomes more challenging with each passing year. This is especially true for infections caused by the opportunistic pathogen Pseudomonas aeruginosa, with its ability to rapidly develop resistance to multiple classes of antibiotics. Although the import of resistance mechanisms on mobile genetic elements is always a concern, the most difficult challenge we face with P. aeruginosa is its ability to rapidly develop resistance during the course of treating an infection. The chromosomally encoded AmpC cephalosporinase, the outer membrane porin OprD, and the multidrug efflux pumps are particularly relevant to this therapeutic challenge. The discussion presented in this review highlights the clinical significance of these chromosomally encoded resistance mechanisms, as well as the complex mechanisms/pathways by which P. aeruginosa regulates their expression. Although a great deal of knowledge has been gained toward understanding the regulation of AmpC, OprD, and efflux pumps in P. aeruginosa, it is clear that we have much to learn about how this resourceful pathogen coregulates different resistance mechanisms to overcome the antibacterial challenges it faces.
Shunting normal‐pressure hydrocephalus: Do the benefits outweigh the risks? (1992)

We performed a multicenter retrospective study in 166 consecutive patients shunted for presumed normal-pressure hydrocephalus (NPH) in the four neurosurgical departments of Amsterdam. Overall improvement occurred in 36%, substantial improvement in 21%. In the subgroup of idiopathic NPH (N = 127), marked improvement was only 15%. The incidence of shunt-responsive NPH in our area was 2.2/million/year. The rate of severe and moderate shunt-related complications was 28%, leading to death or severe residual morbidity in 7%. The substantial benefit/serious harm ration in the whole group was only three (21%/7%), decreasing to 1.7 in idiopathic NPH. By excluding patients at high surgical risk, this ratio might have risen to 10 in the whole group and to six in idiopathic NPH. Our experience is much less favorable than that encountered in the literature, reporting overall improvement in 74% and marked improvement in 55% of the shunted patients. We conclude that NPH is probably a very rare and still overdiagnosed syndrome and that the overall morbidity rate for each patient demonstrating meaningful improvement is high.
Discovery through Total Synthesis: A Retrospective on the Himastatin Problem (2001)

A total synthesis of a structure proposed for himastatin was accomplished. The non-identity of the fully synthetic material with himastatin necessitated a revision of the assigned structure. Confirmation of the revised stereostructure was subsequently confirmed through total synthesis. Among the achievements during this effort were i) stereospecific routes to both anti-cis and syn-cis pyrrolindoline substructures; ii) a practical synthesis to 5-hydroxypiperazic acid in enantiomerically pure form; iii) a Stille coupling leading to a complex bi-indole moiety, and iv) efficient protecting group management throughout the evolving depsipeptide domain. The outlines for a biological pharmacophore have been delineated. The alternating D- and L-substituents in the 6-mer as well as the biaryl linkage connecting the two identical subunits are critical for maintaining biological activity. This pattern is simulated in another antibiotic, and suggests a possible structural trend for future SAR investigations.
Using Sindbis Viral Vectors for Specific Detection and Suppression of Advanced Ovarian Cancer in Animal Models (2004)

We studied the therapeutic value of Sindbis vectors for advanced metastatic ovarian cancer by using two highly reproducible and clinically accurate mouse models: a SCID xenograft model, established by i.p. inoculation of human ES-2 ovarian cancer cells, and a syngenic C57BL/6 model, established by i.p. inoculation of mouse MOSEC ovarian cancer cells. We demonstrate through imaging, histologic, and molecular data that Sindbis vectors systemically and specifically infect/detect and kill metastasized tumors in the peritoneal cavity, leading to significant suppression of the carcinomatosis in both animal models. Use of two different bioluminescent genetic markers for the IVIS Imaging System permitted demonstration, for the first time, of an excellent correlation between vector delivery and metastatic locations in vivo. Sindbis vector infection and growth suppression of murine MOSEC tumor cells indicate that Sindbis tumor specificity is not attributable to a species difference between human tumor and mouse normal cells. Sindbis virus is known to infect mammalian cells using the Mr 67,000 laminin receptor. Immunohistochemical staining of tumor cells indicates that laminin receptor is elevated in tumor versus normal cells. Down-regulated expression of laminin receptor with small interfering RNA significantly reduces the infectivity of Sindbis vectors. Tumor overexpression of the laminin receptor may explain the specificity and efficacy that Sindbis vectors demonstrate for tumor cells in vivo. We show that incorporation of antitumor cytokine genes such as interleukin-12 and interleukin-15 genes enhances the efficacy of the vector. These results suggest that Sindbis viral vectors may be promising agents for both specific detection and growth suppression of metastatic ovarian cancer.
Epidemiology of invasive childhood pneumococcal infections in Israel. The Israeli Pediatric Bacteremia and Meningitis Group (1992)

<h3>Objective.</h3> —To study the epidemiology of childhood pneumococcal invasive infections in Israel as a background for immunization programs. <h3>Design.</h3> —A 2-year (October 1988 through September 1990) prospective, nationwide surveillance of all invasive pediatric pneumococcal infections. <h3>Setting.</h3> —All 25 medical centers hospitalizing children in Israel, including all laboratories performing blood cultures from pediatric patients. <h3>Patients.</h3> —Infants and children aged 0 to 12 years visiting the pediatric emergency department or hospitalized in pediatric departments were included if<i>Streptococcus pneumoniae</i>was isolated from blood or cerebrospinal fluid. <h3>Results.</h3> —Four hundred sixty-nine invasive infections were diagnosed. Pneumonia, bacteremia without apparent focus, meningitis, and cellulitis were found in 39%, 37%, 17%, and 3%, respectively. The annual incidence was 42 per 100000 for children younger than 5 years of age (104 per 100000 for those &lt;12 months old). The two most common serotypes were 1 and 5, which are rare in Western Europe and North America. Eight groups comprised 82% of all invasive infections. Extrapolated to a population in which 100 000 live births occur yearly, the total annual hospitalizations for pneumococci infections was calculated to be 1928 days. The overall case-fatality rate was 2.2%, but it was 30% during the first month of life. <h3>Conclusions.</h3> —Pneumococcal invasive infections are common in children in Israel and carry considerable morbidity. (<i>JAMA</i>. 1992;268:3328-3332)
Human beta satellite DNA: genomic organization and sequence definition of a class of highly repetitive tandem DNA. (1989)

We describe a class of human repetitive DNA, called beta satellite, that, at a most fundamental level, exists as tandem arrays of diverged approximately equal to 68-base-pair monomer repeat units. The monomer units are organized as distinct subsets, each characterized by a multimeric higher-order repeat unit that is tandemly reiterated and represents a recent unit of amplification. We have cloned, characterized, and determined the sequence of two beta satellite higher-order repeat units: one located on chromosome 9, the other on the acrocentric chromosomes (13, 14, 15, 21, and 22) and perhaps other sites in the genome. Analysis by pulsed-field gel electrophoresis reveals that these tandem arrays are localized in large domains (50-300 kilobase pairs) that are marked by restriction fragment length polymorphisms. In total, beta satellite sequences comprise several million base pairs of DNA in the human genome. Analysis of this DNA family should permit insights into the nature of chromosome-specific and nonspecific modes of satellite DNA evolution and provide useful tools for probing the molecular organization and concerted evolution of the acrocentric chromosomes.
The Effect of Faecal Enema on Five Microflora-Associated Characteristics in Patients with Antibiotic-Associated Diarrhoea (1999)

Most MACs were significantly disturbed in patients with AAD. Administration of a human faecal enema modified these changes and relieved diarrhoea, usually within 4 days.
The pathogenesis of respiratory syncytial virus infection in cotton rats. (1978)

The cotton rat is susceptible to respiratory synctial virus infection in both the upper and lower portions of the respiratory tract. Virus replicates to high titer in the nose and lungs and to relatively low titer in the trachea. Immunofluorescence studies demonstrated viral antigen in the nasal epithelium and the bronchial and bronchiolar epithelium but not in the trachea or the alveolar cells of the lungs. Histopathologic changes included a desquamative, exudative rhinitis of moderate severity and a mild proliferative bronchiolitis. Serum neutralizing antibody developed in all animals by the ninth day after infection, reaching extremely high titer in several instances. Unlike the previously described response of experimentally infected infant ferrets, cotton rats are uniformly susceptible to pulmonary infection throughout life, thereby offering a model for long-term pulmonary studies heretofore not available.
Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells (2017)

Pharmacological doses (> 1mM) of ascorbate (a.k.a., vitamin C) have been shown to selectively kill cancer cells through a mechanism that is dependent on the generation of H<sub>2</sub>O<sub>2</sub> at doses that are safely achievable in humans using intravenous administration. The process by which ascorbate oxidizes to form H<sub>2</sub>O<sub>2</sub> is thought to be mediated catalytically by redox active metal ions such as iron (Fe). Because intravenous iron sucrose is often administered to colon cancer patients to help mitigate anemia, the current study assessed the ability of pharmacological ascorbate to kill colon cancer cells in the presence and absence of iron sucrose. In vitro survival assays showed that 10mM ascorbate exposure (2h) clonogenically inactivated 40-80% of exponentially growing colon cancer cell lines (HCT116 and HT29). When the H<sub>2</sub>O<sub>2</sub> scavenging enzyme, catalase, was added to the media, or conditionally over-expressed using a doxycycline inducible vector, the toxicity of pharmacological ascorbate was significantly blunted. When colon cancer cells were treated in the presence or absence of 250µM iron sucrose, then rinsed, and treated with 10mM ascorbate, the cells demonstrated increased levels of labile iron that resulted in significantly increased clonogenic cell killing, compared to pharmacological ascorbate alone. Interestingly, when colon cancer cells were treated with iron sucrose for 1h and then 10mM ascorbate was added to the media in the continued presence of iron sucrose, there was no enhancement of toxicity despite similar increases in intracellular labile iron. The combination of iron chelators, deferoxamine and diethylenetriaminepentaacetic acid, significantly inhibited the toxicity of either ascorbate alone or ascorbate following iron sucrose. These observations support the hypothesis that increasing intracellular labile iron pools, using iron sucrose, can be used to increase the toxicity of pharmacological ascorbate in human colon cancer cells by a mechanism involving increased generation of H<sub>2</sub>O<sub>2</sub>.
Monolithic Two-Dimensional Diode Laser Arrays (1987)

Two-dimensional diode laser arrays are being developed for near-term application as efficient incoherent high-power pump sources for solid-state lasers and for uses in the long term as coherent primary sources. A technique for fabricating such arrays has been demonstrated which makes use of small deflecting mirrors integrated with diode laser elements that are formed on a semiconductor wafer surface by lithographic techniques. Monolithic arrays of over 100 elements have been fabricated with good uniformity and a power density over 40 W/cm<sup>2</sup> of wafer area.
DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics (2014)

Aptamer modified gold nanoparticles target malignant cells. Anti-cancer therapeutics are released after cleavage of a self-immolative linker by intracellular triggers.
Blue Laser Diode Enables Underwater Communication at 12.4 Gbps (2017)

To enable high-speed underwater wireless optical communication (UWOC) in tap-water and seawater environments over long distances, a 450-nm blue GaN laser diode (LD) directly modulated by pre-leveled 16-quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) data was employed to implement its maximal transmission capacity of up to 10 Gbps. The proposed UWOC in tap water provided a maximal allowable communication bit rate increase from 5.2 to 12.4 Gbps with the corresponding underwater transmission distance significantly reduced from 10.2 to 1.7 m, exhibiting a bit rate/distance decaying slope of -0.847 Gbps/m. When conducting the same type of UWOC in seawater, light scattering induced by impurities attenuated the blue laser power, thereby degrading the transmission with a slightly higher decay ratio of 0.941 Gbps/m. The blue LD based UWOC enables a 16-QAM OFDM bit rate of up to 7.2 Gbps for transmission in seawater more than 6.8 m.
What Should Vaccine Developers Ask? Simulation of the Effectiveness of Malaria Vaccines (2008)

We present for the first time a stochastic simulation approach to compare likely effects on morbidity, mortality and transmission of a range of malaria vaccines and vaccine combinations in realistic epidemiological and health systems settings. The results raise several issues for vaccine clinical development, in particular appropriateness of vaccine types for different transmission settings; the need to assess transmission to the vector and duration of protection; and the importance of deployment additional to the EPI, which again may make the issue of number of doses required more critical. To test the validity and robustness of our conclusions there is a need for further modeling (and, of course, field research) using alternative formulations for both natural and vaccine induced immunity. Evaluation of alternative deployment strategies outside EPI needs to consider the operational implications of different approaches to mass vaccination.
Solar Cosmic-Ray Measurements at High Heliocentric Latitudes (1976)

A brief review is presented of what might result from a program of solar cosmic ray observations on 'out-of-the-ecliptic' spacecraft. The following topics are discussed: (1) The magnetic fields of the sun at high latitudes, (2) propagation of fast charged particles in the solar corona and in interplanetary space at high latitudes, (3) origin of interplanetary particle populations and the solar wind, (4) other particle phenomena in interplanetary space (e.g., acceleration of shock waves), and (5) effect of spacecraft mission characteristics on solar cosmic ray studies at high latitudes. Maps of polar coronal magnetic fields are shown.