gebhart/patrepeval huggingface dataset:
Semantic social network portal for collaborative online communities (2005)

Purpose The motivation for this investigation is to apply social networking features to a semantic network portal, which supports the efforts in enterprise training units to up‐skill the employee in the company, and facilitates the creation and reuse of knowledge in online communities. Design/methodology/approach The paper provides an overview of an emerging area for work‐related research in the field of knowledge management and collaborative online communities. Findings The growing number of social network online communities requires a systematic assessment of the application and design of social network technologies, which makes this study relevant and timely. Practical implications This paper gives guidance in an emerging research area with major implications for online communities and human resources management. Originality/value Fulfils a need, since a lack of literature in the field is apparent.
Oligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: synthesis and Hybridization Properties (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: synthesis and Hybridization PropertiesSergei Gryaznov and Jer-Kang ChenCite this: J. Am. Chem. Soc. 1994, 116, 7, 3143–3144Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00086a062https://doi.org/10.1021/ja00086a062research-articleACS PublicationsRequest reuse permissionsArticle Views696Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Location-based activity recognition using relational Markov networks (2005)

In this paper we define a general framework for activity recognition by building upon and extending Relational Markov Networks. Using the example of activity recognition from location data, we show that our model can represent a variety of features including temporal information such as time of day, spatial information extracted from geographic databases, and global constraints such as the number of homes or workplaces of a person. We develop an efficient inference and learning technique based on MCMC. Using GPS location data collected by multiple people we show that the technique can accurately label a person’s activity locations. Furthermore, we show that it is possible to learn good models from less data by using priors extracted from other people’s data. 1
Optoelectronic semiconductor devices (1994)

Basics. Semiconductor Dynamics. Junctions. Properties of Light. Light Emitting Diodes. Semiconductor Lasers. Photoconductors. P-n Diodes. Avalanche Photodiodes. Phototransistors. Materials. Technology. Packaging and Testing. Future Developments.
Surface photo-grafting of polyurethane with 2-hydroxyethyl acrylate for promotion of human endothelial cell adhesion and growth (2000)

Cytocompatible polyurethane (PU) surface was prepared by photo-grafting 2-hydroxyethyl acrylate (HEA) onto the membrane surface. Graft polymerization was conducted by combining the use of the photo-oxidation and irradiation grafting. PU membrane was photo-oxidized to introduce the hydroperoxide groups onto the surface, then the membrane, immersed previously in monomer solution, was irradiated under UV light. The ATR-FTIR spectra, element spectroscopy for chemical analysis (ESCA), scanning electron microscopy (SEM) and water contact angle characterized the grafted copolymers and verified the occurrence of graft polymerization. The results showed that UV irradiation could realize the graft polymerization effectively and the grafting was confined within the surface layer. The grafted membrane showed minimal surface morphology. Human umbilical vein endothelial (HUVE) cells were seeded on the grafted surface. The performance of the surface in cell attachment and growth correlated with the oxygen content and mainly the carbonyl content on the surface. Cells were spread more extensively and grew faster on the surface with a higher oxygen content.
Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models (2018)

These studies provide the first report of novel and disease-relevant 3D in-vitro models representing pancreatic tumor, stromal and immune components using primary organoid co-cultures representative of the tumor-microenvironment. These models promise to facilitate the study of tumor-stroma and tumor-immune interaction and may be valuable for the assessment of immunotherapeutics such as checkpoint inhibitors in the context of T-cell infiltration.
New efficient fillers for unlimited word recognition and keyword spotting (2002)

Describes our complete results for improved lexical fillers as well as two new kinds of fillers, gives their results in unlimited speech recognition as well as for keyword spotting and compares them to the acoustic-phonetic filler in the case of keyword spotting. Tests have been conducted on different vocabularies derived from ATIS (Air Travel Information System) and the Wall Street Journal database. Results for keyword spotting show the superiority of the independent lexical phonemic filler that combines accuracy (92% for a false alarm rate of 1.2 FA/h/kw) as well as task-independent training. As for new-word detection, the syllabic and the independent lexical fillers perform quite well, and allow relevant detection of the phonetic transcription.
PEAS-III: an ASIP design environment (2002)

In this paper, an architectural level processor design environment PEAS-III is proposed. Pipelined processors designed by this system can include multi-cycle operation, delayed branch and external interrupt. The data path and control logic of the processor are generated from the clock based micro-operation description of instructions. The ease of large design space exploration through experiments using several subsets of MIPS R3000 instruction set.
[Elements of differential diagnosis in chronic headache in children]. (1987)

In this paper are discussed the commonest causes of chronic headache in childhood. Every cause is analyzed with reference to the occurrence and the quality of the pain, the associated symptoms and signs and the appropriate diagnostic tests. At the end is a list of the reasons to conduct a cerebral CT scan in a patient with chronic headache.
Phase I Dose-Escalation Study of the Novel Antiandrogen BMS-641988 in Patients with Castration-Resistant Prostate Cancer (2010)

Although the clinical outcomes of predominantly stable disease and partial agonism were similar to what was observed in the preclinical evaluation of the compound, the limited antitumor activity of BMS-641988 at therapeutic dose levels coupled with an episode of seizure activity led to study closure.
Automatic fine-grain locking using shape properties (2011)

We present a technique for automatically adding fine-grain locking to an abstract data type that is implemented using a dynamic forest -i.e., the data structures may be mutated, even to the point of violating forestness temporarily during the execution of a method of the ADT. Our automatic technique is based on Domination Locking, a novel locking protocol. Domination locking is designed specifically for software concurrency control, and in particular is designed for object-oriented software with destructive pointer updates. Domination locking is a strict generalization of existing locking protocols for dynamically changing graphs. We show our technique can successfully add fine-grain locking to libraries where manually performing locking is extremely challenging. We show that automatic fine-grain locking is more efficient than coarse-grain locking, and obtains similar performance to hand-crafted fine-grain locking.
Frequency-shaped cost functionals - Extension of linear-quadratic-Gaussian design methods (1980)

The linear-quadratic-Gaussian method for feedback control design is extended to include frequency-shaped weighting matrices in the quadratic cost functional. This extension provides a means to meet classical design requirements with automated computational procedures of modern control theory. A design algorithm to optimize frequency-shaped cost functional requires definition of new states and the solution of a modified linearquadratic-Gaussian problem. Four examples are presented to demonstrate frequency shaping methodology: 1) aircraft in lateral wind, 2) an industrial crane, 3) vibration control in helicopters, and 4) a system with truncated modes.
Role of Antibodies against Outer-membrane Proteins in Murine Resistance to Infection with Encapsulated Klebsiella pneumoniae (1989)

In the assessment of immunity to the encapsulated virulent strain of Klebsiella pneumoniae and its avirulent mutant defective for capsular polysaccharide (CPS), killed bacterial vaccine of both strains could protect mice equally against challenge with 100 x LD50 of encapsulated wild strain. Antisera to each strain conferred the same level of protection on naive mice upon transfer; the protective anti-mutant serum was highly capable of opsonizing the encapsulated bacteria. In addition to the common antigenic components shared by both strains, the wild strain had antigen(s) unrelated to the mutant since the protective capacity of the anti-wild serum was not affected by preabsorption with the mutant strain; the protection conferred by the anti-mutant serum was mediated by antibodies against non-capsular antigens since the antiserum did not contain antibodies against purified CPS detectable by ELISA. As possible candidates among the non-capsular antigens, outer-membrane proteins (OMPs) extracted from the mutant strain were examined for their immunogenicity. Immunoblotting of the protein-containing fraction and ELISA using LPS-free OMP suggested that a number of proteins were involved in the immune response evoked by K. pneumoniae. Furthermore, mice immunized with OMP or anti-OMP serum could overcome a lethal challenge with the wild strain. These results indicated that OMPs of K. pneumoniae are implicated as the protective antigens and may pave the way for the development of non-capsular, proteinaceous vaccines.
Long circulating, cationic liposomes containing amino‐PEG‐phosphatidylethanolamine (1994)

Ligand attachment to polyethylene glycol (PEG) grafted, long circulating liposomes at the polymer terminus is of interest for targeting but the effect of positively charged groups is unknown. Amino-polyethylene glycol-phosphatidylethanolamine (AminoPEG-PE), prepared in four steps from alpha-amino-omega-hydroxy-PEG, was tested for influence on liposome interactions in vivo: blood circulation and biodistribution. Despite surface amines on each liposome conferring cationic behavior, in vivo properties are comparable to those obtained with methoxy-PEG-PE. The consequences are profound for targeting and possibly systemic delivery of cationic lipidic-polynucleotide complexes.
5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition (1994)

The 5-hydroxytryptamine1A receptor (5-HT1AR) is a G-protein-coupled receptor negatively coupled to adenylyl cyclase (AC). We have studied the functional domains of 5-HT1AR using synthetic peptides to block or mimic receptor function. The entire second intracellular loop (5-HT1AR-i2) and the carboxyl end of the third intracellular loop (5-HT1AR-i3-C) strongly inhibited forskolin-stimulated AC activity. These effects were not additive with those of 5-HT. Like 5-HT, the peptides 5-HT1AR-i3-C and -i2 weakly inhibited AIF4- and Mn2+ stimulated AC activity. 5-HT1AR binding assays indicated that peptides could interact with the same G-protein pool as the 5-HT1AR. 5-HT1AR-i3-C- and -i2-stimulated [35S]guanosine 5'-O-(thiotriphosphate) binding on Go/Gi proteins. Only 5-HT1AR-i3-C partially adopted an alpha-helical conformation in solution. These data show that different domains in the 5-HT1AR second and third intracellular loops can couple to and activate Gi proteins in order to mediate AC inhibition. Peptide-induced AC inhibition was not sensitive to pertussis toxin as opposed to the 5-HT1AR-mediated effect. Our data show that the 5-HT1AR and the 5-HT1AR peptides activate Gi proteins in a slightly different manner.
Optimal hardware and software arithmetic coding procedures for the Q-Coder (1988)

The Q-Coder is an important new development in arithmetic coding. It combines a simple but efficient arithmetic approximation for the multiply operation, a new formalism which yields optimally efficient hardware and software implementations, and a new form of probability estimation. This paper describes the concepts which allow different, yet compatible, optimal software and hardware implementations. In prior binary arithmetic coding algorithms, efficient hardware implementations favored ordering the more probable symbol (MPS) above the less probable symbol (LPS) in the current probability interval. Efficient software implementation required the inverse ordering convention. In this paper it is shown that optimal hardware and software encoders and decoders can be achieved with either symbol ordering. Although optimal implementation for a given symbol ordering requires the hardware and software code strings to point to opposite ends of the probability interval, either code string can be converted to match the other exactly. In addition, a code string generated using one symbol-ordering convention can be inverted so that it exactly matches the code string generated with the inverse convention. Even where bit stuffing is used to block carry propagation, the code strings can be kept identical.
Molecular Typing Shows a High Level of HLA Class I Incompatibility in Serologically Well Matched Donor/Patient Pairs: Implications for Unrelated Bone Marrow Donor Selection (1998)

In comparison with HLA-matched sibling bone marrow transplants, unrelated donor transplants are associated with increased graft-versus-host disease and graft failure. This is likely in part due to HLA incompatibilities not identified by current matching strategies. High resolution DNA-based typing methods for HLA class II loci have improved donor selection and treatment outcome in unrelated donor bone marrow transplantation. By using DNA-based typing methods for HLA-A and -B on a cohort of 100 potential bone marrow donor/patient pairs, we find that serological typing for HLA class I is limited in its ability to identify incompatibilities in unrelated pairs. Furthermore, the incompatibilities identified are associated with the presence at high frequency of alloreactive cytotoxic T-lymphocyte precursors. DNA typing also indicates that HLA-C mismatches are common in HLA-A and -B serologically matched pairs. Such mismatches appear to be significantly less immunogenic with respect to cytotoxic T-lymphocyte recognition, but are expected to influence natural killer cell activity. Thus, improved resolution of HLA class I shows many previously undisclosed mismatches that appear to be immunologically functional. Use of high resolution typing methods in routine matching is expected to improve unrelated donor selection and transplant outcome.
Biodegradable nanoparticles for intravascular drug delivery (2003)

Atherosclerosis is a disease that is characterized by accumulation of lipids, cells and minerals at damaged sites of the arterial wall. It results in the development of a plaque, hardening of the artery and eventually the formation of thrombi. This leads to a decreased blood flow at the site of the plaque. Heart attacks and strokes that result from the decreased blood flow or the release of thrombi are the main cause of mortality in the western world.<br/>Many techniques are available to restore the blood flow at the site of the atherosclerotic lesion. Percutaneous transluminal angioplasty (PTA) is used most frequently. It involves the introduction of a balloon catheter at the site of the plaque. The balloon is inflated and deflated. The inflation and deflation procedure is repeated until the plaque is deformed to such an extent that the diameter equals the original diameter of the artery.<br/>Although the blood flow is initially restored, restenosis takes place in 30 to 50% of the patients within three to six months after the treatment. An important step in the process that leads to restenosis is the migration and proliferation of smooth muscle cells. Therefore, medication that prevents migration and proliferation of smooth muscle cells could lead to a reduction in the incidence of restenosis. As smooth muscle cell migration and proliferation take place in the first 4 weeks after treatment, sustained drug delivery for at least 1 month is desirable.<br/>Whereas systemic administration of drugs appeared to be inefficient and is hampered by adverse side effects, local delivery of drugs seems to be a promising approach. However, drugs locally delivered as an aqueous solution had a short residence time in the arterial wall. Therefore, drug carriers were used to extend the residence time of the drug in the arterial wall. Due to their small size, nanoparticles seem to be suited as a drug carrier, and the use of biodegradable polymers for the preparation of the nanoparticles minimizes the long-term risk of adverse tissue reactions. Furthermore, the use of particles allows modification of the surface, thus enhancing the targeting of particles in the arterial wall. It was the aim of this study to prepare, characterize and surface-modify biodegradable nanoparticles that can be used for the delivery of anti-proliferative drugs to atherosclerotic vascular walls. Furthermore, the degradation behavior of nanoparticles, the release of two anti-proliferative drugs from the nanoparticles and the delivery of nanoparticles to arterial porcine carotid arteries were studied in vitro.
Double-stranded structure for hyaluronic acid in ethanol-aqueous solution as revealed by circular dichroism of oligomers (1988)

The sigmoidal nature of circular dichroism (CD) changes for hyaluronic acid solutions as a function of solvent composition or temperature is studied as a function of chain length by using oligomers. We find a chain length effect with approximately nine disaccharides required for the structural transition as a function of organic solvent, which proves that the transition is cooperative with large transition enthalpy and entropy. The transition also depends on sample concentration as expected for strand association, and this was investigated in detail for oligomers 12 and 16 disaccharides long. Indeed, it was possible to prevent completely the transition in mixed solvent with sufficient dilution of these oligomers, which demonstrates strand association. The CD data in mixed solvent as a function of oligomer concentration were fit with various models for association of two and more strands. Simplex methods were used to investigate the vector space of unknowns for the models, and two-strand models were shown to consistently give a better fit. A cooperative two-strand zipper model which allows relative sliding of the chains had the smallest fitting error and produced the following thermodynamic parameters (in terms of a duplex of disaccharide units) for the ordered structure in an aqueous solution containing 45% v/v ethanol, 12.5 mM NaH2PO4, and 7.5 mM H3PO4: enthalpy of growth, -1.0 +/- 0.3 kcal mol-1; entropy of growth, -2.3 +/- 1.3 eu mol-1; enthalpy of initiation, -20 +/- 3 kcal mol-1; entropy of initiation, -71 +/- 15 eu mol-1. The results are consistent with a double-stranded and helical structure for hyaluronic acid in solutions of reduced dielectric constant.
A temperature regulator for microtiter plates (1991)

Journal Article A temperature regulator for microtiter plates Get access Donald Seto Donald Seto 147-75 Division of Biology California Institute of TechnologyPasadena, CA 91125, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 9, 11 May 1991, Page 2506, https://doi.org/10.1093/nar/19.9.2506 Published: 11 May 1991 Article history Received: 25 February 1991 Published: 11 May 1991
Polyglot (2007)

Protocol reverse engineering, the process of extracting the application-level protocol used by an implementation, without access to the protocol specification, is important for many network security applications. Recent work [17] has proposed protocol reverse engineering by using clustering on network traces. That kind of approach is limited by the lack of semantic information on network traces. In this paper we propose a new approach using program binaries. Our approach, shadowing, uses dynamic analysis and is based on a unique intuition - the way that an implementation of the protocol processes the received application data reveals a wealth of information about the protocol message format. We have implemented our approach in a system called Polyglot and evaluated it extensively using real-world implementations of five different protocols: DNS, HTTP, IRC, Samba and ICQ. We compare our results with the manually crafted message format, included in Wireshark, one of the state-of-the-art protocol analyzers. The differences we find are small and usually due to different implementations handling fields in different ways. Finding such differences between implementations is an added benefit, as they are important for problems such as fingerprint generation, fuzzing, and error detection.
Analyst Forecasting Errors: Additional Evidence (1997)

Analyst forecasting errors are approximately as large as Dreman and Berry (1995) documented, and an optimistic bias is evident for all years from 1985 through 7996. In contrast to their findings, I show that analyst forecasting errors and bias have decreased over lime. Moreover, the optimistic bias in quarterly forecasts was absent for SP (2) firms with comparatively large amounts of market capitalization, absolute value of earnings forecast, and analyst following; and (3) firms in certain industries.
Does trait coping exist? A momentary assessment approach to the evaluation of traits. (1999)

This study investigated the extent to which momentary reports of coping are a traitlike phenomenon and the validity of a questionnaire assessment of coping style. Participants (N = 96) completed the questionnaire, then monitored stressful events and coping activities for 2 days using a hand-held computer that administered a brief assessment every 40 min. Momentary reports exhibited a sizable traitlike component: Individual differences accounted for 42% of the variance for 2 coping items and 15-30% of the variance for 15 items. The questionnaire assessment of coping style was a poor predictor of average momentary coping; the coping style measure and the aggregated momentary measure of trait coping shared 23% of their variance for religion and 0-12% for the 16 other coping measures. Self-report assessments of trait coping are poor measures of the trait component of momentary coping and very poor predictors of coping in specific situations.
Diabetes and Risk of Parkinson’s Disease (2011)

This large study showed that diabetes was associated with a higher future risk of PD and the nature of this association warrants further investigation.