gebhart/patrepeval huggingface dataset:
Mechanical Properties of Cross-Linked Hyaluronic Acid/Poly-(l-lysine) Multilayer Films (2004)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTMechanical Properties of Cross-Linked Hyaluronic Acid/Poly-(l-lysine) Multilayer FilmsDominique Collin, Philippe Lavalle, Juan Méndez Garza, Jean-Claude Voegel, Pierre Schaaf, and Philippe MartinotyView Author Information Laboratoire de Dynamique des Fluides Complexes (CNRS/ULP UMR 7506), Université Louis Pasteur, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France; INSERM Unité 595, Faculté de Chirurgie Dentaire, Université Louis Pasteur, 11 rue Humann, F-67085 Strasbourg Cedex, France; Mécanique et Ingénierie Cellulaire et Tissulaire, UMR CNRS 7563-LEMTA, Faculté de Médecine, 54500 Vandœuvre-lès-Nancy, France; and Institut Charles Sadron (CNRS UPR 22), 6 rue Boussingault, F-67083 Strasbourg Cedex, France Cite this: Macromolecules 2004, 37, 26, 10195–10198Publication Date (Web):November 26, 2004Publication History Received30 June 2004Revised15 September 2004Published online26 November 2004Published inissue 1 December 2004https://pubs.acs.org/doi/10.1021/ma048683ghttps://doi.org/10.1021/ma048683gbrief-reportACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views975Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amorphous materials,Compression,Polyelectrolytes,Thickness,Thin films Get e-Alerts
[Plasma chitotriosidase activity in Argentinian patients with Gaucher disease, various lysosomal diseases and other inherited metabolic disorders]. (1997)

The striking and apparent specific elevation of the activity of chitotriosidase found in plasma from patients with Gaucher disease (GD) Type 1 (Mc Kusick 230800) is considered a new diagnostic hallmark of GD and should prove useful in assessing clinical manifestations and monitoring enzyme supplementation therapy. Further data have suggested that the increased levels of chitotriosidade activity in plasma from patients with unexplained diseases may be indicative of a lysosomal storage disorder. We present here an experience of the plasmatic chitotriosidase in an Argentinean population consisting of three groups: a) 25 healthy controls; b) subjects related with GD: 3 patients Type 1, 3 obligated heterocygotes and 1 patient with an atypical variant of GD; c) 42 patients with a precise nosologycal definition of inherited error of metabolism (IEM) and 5 patients presumably affected by a lysosomal pathology but without enzymatic confirmation. Methylumbellypheryl-tri-N-acetyl chitotrioside hydrolase activity was markedly increased: the mean activity being > 600 times and > 100 times the mean value in plasma of our healthy control (mean 17 nmol/min/ml, range 6-60.4 nmol/min/ml) in the plasma of the patients of Gaucher Type 1 disease and an atypical variant of GD, respectively. In the two more affected patients the elevated levels of chitotriosidase activity ran parallel to the severity of the disease and also as a response to the supplementation enzymatic therapy with a decrease of 50% of its activity at 10 months of therapy at a dose of 30 u/kg/month. Moreover, no increase of chitotriosidase activity was found in the 3 obligated heterozygotes of Gaucher Type 1 and Type 2 disease or in any other of the IEM. Chitotriosidase activity was absent in plasma of 2 control subjects and in 4 patients with exact diagnosis of an IEM. The physiological role of the human chitinase still has to be established and warrants further investigation and the natural consequence of the high frequency of a genetic deficiency in man. Meanwhile, reports on the purification and characterization of human chitotriosidase with chitinolytic activity toward chitin-containing pathogens and on the cloning of cDNA encoding chitinase will be crucial to obtain a better insight into this new chapter of medical genetics.
Waveguide-Plasmon Polaritons: Strong Coupling of Photonic and Electronic Resonances in a Metallic Photonic Crystal Slab (2003)

Strong coupling between localized particle plasmons and optical waveguide modes leads to drastic modifications of the transmission of metallic nanowire arrays on dielectric waveguide substrates. The coupling results in the formation of a new quasiparticle, a waveguide-plasmon polariton, with a surprisingly large Rabi splitting of 250 meV. Our experimental results agree well with scattering-matrix calculations and a polariton-type model. The effect provides an efficient tool for photonic band gap engineering in metallodielectric photonic crystal slabs. We show evidence of a full one-dimensional photonic band gap in resonant plasmon-waveguide structures.
Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte–colony‐stimulating factor (2005)

Granulocyte product collected by centrifugation leukapheresis from G-CSF-stimulated donors can be effectively stored at subphysiologic temperature for 24 hours with preservation of functional activity. Storage at 10 degrees C appears to be slightly superior to storage at 22 degrees C.
Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow (2005)

The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over lymphopoiesis, a response that supports the reactive neutrophilia that follows infection. Here we demonstrate that this specialization for granulopoiesis is determined by inflammation-induced reductions of growth and retention factors, most significantly stem cell factor and CXCL12, which act preferentially to inhibit lymphoid development. These hierarchical effects suggest that the normal equilibrium of leukocyte production in bone marrow is determined by lymphopoiesis' higher demand for specific growth factors and/or retention signals. Inflammation regulates this balance by reducing growth factors that have less impact on developing neutrophils than lymphocytes. We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development in a common niche and propose that the leukopoietic equilibrium is specified by limiting amounts of developmental resources.
In vitrotoxicity studies of polymer-coated gold nanorods (2010)

We evaluated cellular responses to polymer-treated gold nanorods, which were synthesized using the standard wet-chemistry method that utilizes hexadecyltrimethylammonium bromide (CTAB). The nanorod dispersions were coated with either polystyrene sulfonate (PSS) or polyethylene glycol (PEG). Two sizes of nanorods were tested, with optical responses peaking at 628 and 773 nm. The cells were from mammary adenocarcinoma (SKBR3), Chinese Hamster Ovary (CHO), mouse myoblast (C2C12) and Human Leukemia (HL60) cell lines. Their mitochondrial function following exposure to the nanorods were assessed using the MTS assay. We found PEGylated particles to have superior biocompatibility compared with PSS-coated nanorods, which showed substantial cytotoxicity. Electron microscopy showed no cellular uptake of PEGylated particles compared with their PSS counterparts. PEGylated gold nanorods also exhibited better dispersion stability in the presence of cell growth medium; PSS-coated rods tended to flocculate or cluster. In the case of the PSS particles, toxicity correlated with surface area across the two sizes of nanorods studied
Contextuality offers device-independent security (2010)

The discovery of quantum key distribution by Bennett and Brassard (BB84) bases on the fundamental quantum feature: incompatibility of measurements of quantum non-commuting observables. In 1991 Ekert showed that cryptographic key can be generated at a distance with help of entangled (correlated) quantum particles. Recently Barrett, Hardy and Kent showed that the non-locality used by Ekert is itself a good resource of cryptographic key even beyond quantum mechanics. Their result paved the way to new generation of quantum cryptographic protocols - secure even if the devices are built by the very eavesdropper. However, there is a question, which is fundamental from both practical and philosophical point of view: does Nature offer security on operational level based on the original concept behind quantum cryptography - that information gain about one observable must cause disturbance to another, incompatible one? Here we resolve this problem by using another striking feature of quantum world - contextuality. It is a strong version of incompatibility manifested in the famous Kochen-Specker paradox. The crucial concept is the use of a new class of families of bipartite probability distributions . We show that if two persons share systems which locally exhibit the Kochen-Specker paradox and, in addition, exhibit perfect correlations, then they can extract secure key, even if they do not trust the quantum devices. This is the first operational protocol that directly implements the fundamental feature of Nature: the information gain vs. disturbance trade-off. For sake of proof we exhibit a new Bell's inequality which is interesting in itself. The security is proved not by exploiting strong violation of the inequality by quantum mechanics (as one usually proceeds), but rather by arguing, that quantum mechanics cannot violate it too much.
Dementia of the Alzheimer Type and Multi‐infarct Dementia (1984)

Patients who had Alzheimer's disease-senile dementia of the Alzheimer type (AD/SDAT) or multi-infarct dementia (MID) were compared with a group of controls. Demented patients had approximately the same degree of dementia and the same duration of illness. The MID group had a significantly higher mean age than the AD/SDAT group. Sixty-three per cent of the AD/SDAT patients were free of other diseases, while 65 per cent of the MID patients had cardiovascular disease. Thirty per cent of the MID patients had a history of previous depression, while only 5 per cent of the AD/SDAT patients had had depression. At the time of the investigation, however, AD/SDAT patients showed significantly more signs of depression than the MID patients. Focal neurologic signs were found in 70 per cent of the MID patients and only 6 per cent of the AD/SDAT patients. The electrocardiogram was normal for every AD/SDAT patient, while 75 per cent of the MID patients had abnormal ECGs. Electroencephalography showed generalized slow frequencies in 79 per cent of the AD/SDAT patients and localized slow frequencies and abnormalities in 65 per cent of the MID patients. Computed tomography of the brain showed that MID patients had significantly greater dilation of the ventricular system, while cortical atrophy did not differ significantly among the three groups. Homovanillic acid in the cerebrospinal fluid was significantly lower in the AD/SDAT group as compared with controls.
Influence of hemodialysis on selenium blood levels. (2000)

Selenium (Se) is considered an essential and very important trace element for humans. Blood Se levels in chronic hemodialysis (HD) patients are frequently reported to be lower than in controls. The aim of this study was to evaluate these lower Se blood levels with respect to the basic renal disease, duration of dialysis treatment, type of the membrane and dialysis solution used. We tried also to use the polynomial curve as a graphical method for rapid evaluation of a large number of Se blood levels. Se blood levels were measured before and after HD in 95 patients on chronic hemodialysis and in a control group of 20 healthy volunteers. Se blood levels were measured by atomic absorption spectrophotometry. Statistically significant increases of Se blood levels were found after HD (p < 0.001). During HD, the relatively high Se blood levels decreased and low levels increased but remained below the range of physiological values. These levels were lower than those of the control group (p < 0.001). Of the different dialysis membranes used, the greatest changes in Se blood levels were measured after HD with cuprophan membranes (p < 0.001). No significant difference in Se blood level in respect to the underlying kidney disease (chronic glomerulonephritis, tubulointerstitial nephritis, polycystic kidney disease, diabetic nephropathy) was revealed. No association of predialytic Se blood levels and the length of dialysis treatment was found. Concluding our results suggests low selenium content in dialysis solution and show that, in respect to the importance of Se for humans, its substitution is desirable.
AU-rich elements and associated factors: are there unifying principles? (2005)

The control of mRNA stability is an important process that allows cells to not only limit, but also rapidly adjust, the expression of regulatory factors whose over expression may be detrimental to the host organism. Sequence elements rich in A and U nucleotides or AU-rich elements (AREs) have been known for many years to target mRNAs for rapid degradation. In this survey, after briefly summarizing the data on the sequence characteristics of AREs, we present an analysis of the known ARE-binding proteins (ARE-BP) with respect to their mRNA targets and the consequences of their binding to the mRNA. In this analysis, both the changes in mRNA stability and the lesser studied effects on translation are considered. This analysis highlights the multitude of mRNAs bound by one ARE-BP and conversely the large number of ARE-BP that associate with any particular ARE-containing mRNA. This situation is discussed with respect to functional redundancies or antagonisms. The potential relationship between mRNA stability and translation is also discussed. Finally, we present several hypotheses that could unify the published data and suggest avenues for future research.
Functional analysis of a palindromic sequence required for normal replication of several staphylococcal plasmids. (1987)

Most small multicopy antibiotic-resistance plasmids of Staphylococcus aureus contain a major axis of hyphenated dyad symmetry (palA) that is required for normal replication and stability, although located outside of the minimal replicon. Rearrangements affecting palA cause plasmid instability, a marked reduction in copy number, and the accumulation of large quantities of strand-specific circular single-stranded plasmid DNA. In view of the recent observation that pT181 initiates replication by a nick and 3'-extension mechanism (S. Khan, personal communication), it is suggested that these plasmids replicate by an asymmetric rolling-circle mechanism in which the displaced plus strand remains single stranded until palA is exposed, forming a hairpin that serves as the lagging strand origin.
Regulation of TLR7/9 signaling in plasmacytoid dendritic cells (2012)

Plasmacytoid dendritic cells (pDCs), also known as type I interferon (IFN)-producing cells, are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nucleic acids derived from virus, bacteria or dead cells. PDCs selectively express endosomal Toll-like receptor (TLR) 7 and TLR9, which sense viral RNA and DNA respectively. Following type I IFN and cytokine responses, pDCs differentiate into antigen presenting cells and acquire the ability to regulate T cell-mediated adaptive immunity. The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance, inflammation and tumor microenvironments. In this review, we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors.
Characterization of Hantaan Virus Envelope Glycoprotein Antigenic Determinants Defined by Monoclonal Antibodies (1989)

A panel of 24 monoclonal antibodies (MAbs) to the G1 or G2 envelope glycoproteins of Hantaan virus were used to determine the surface topography and functional properties of antigenic sites. Nine distinct, partially overlapping antigenic sites, two on G1 and seven on G2, were demonstrated by competitive binding assays. Analyses of the antigenic sites by haemagglutination (HA) inhibition and plaque-reduction neutralization tests showed that all of the sites, except one on G1, were related to viral HA. Only one of the G1 antigenic sites and two of the G2 sites were involved in virus neutralization. These results suggest that certain epitopes related to HA were not critical for virus neutralization. The nine antigenic sites could be further divided into 13 based upon the serological cross-reactivity of MAbs with viruses representative of each of the four known antigenic groups within the Hantavirus genus of Bunyaviridae, i.e. Hantaan, Seoul, Puumala and Prospect Hill viruses.
Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years (1998)

Competition for respiration between substrates in animal tissues has been known for at least 80 years. The most important interaction, quantitatively is between glucose and fatty acids. The starting point in 1963 for the so called Glucose Fatty Acid Cycle was the realisation that the metabolic relationship between glucose and fatty acids is reciprocal and not dependent. Glucose provision promotes glucose oxidation and glucose and lipid storage, and inhibits fatty acid oxidation. Provision of free fatty acids promotes fatty acid oxidation and storage, inhibits glucose oxidation and may promote glucose storage if glycogen reserves are incomplete. This review is concerned predominantly with evidence in man in vivo. In the authors opinion the evidence for inhibitory effects of fatty acids on whole body glucose utilization ad oxidation (predominantly muscles) is decisive and enzyme mechanisms mediating these effects are well established. There is also much evidence that fatty acid oxidation inhibits glucose oxidation and stimulates glucose formation in liver and again enzyme mechanism are known. A permissive role for fatty acids in the insulin secretory response of islet beta-cells has now been firmly established and can be visualised as a mechanism to protect continuing provision of respiratory substrate. Longer term exposure of islet beta-cells to fatty acids impairs the insulin secretory response to glucose and mechanisms are known. There is compelling evidence that fatty acid oxidation may impair glucose oxidation in uncontrolled Type 1 and Type 2 diabetes, but no convincing evidence that fatty acids have a role in diminished glucose storage (glycogen deposition) in Type 2 diabetes. The inhibition of glucose storage which may follow prolonged elevation of plasma FFA in man and experimental animals is associated with glycogen repletion whereas the inhibition of glucose storage in Type 2 diabetes is associated with glycogen depletion. The precise role of fatty acids in disturbed carbohydrate metabolism in Type 2 diabetes is an area where future progress is confidently predicted.
Design, Modeling, and Characterization of a Miniature Robotic Fish for Research and Education in Biomimetics and Bioinspiration (2012)

In this paper, we present the design of a biomimetic robotic fish with a modular caudal fin and analyze its performance. The robot's propulsion system is experimentally characterized for different caudal fin geometries by using an ad hoc thrust-measurement system. The static thrust produced by the vibrating tail is expressed in terms of the oscillatory Reynolds number and compared with similar findings in the literature. Nonlinear vibrations of the propulsive tail are modeled using modal analysis and classical results from the study of large vibrations of slender cylinders in fluids. This analysis allows for computing the oscillatory Reynolds number in terms of the input parameters to the tail vibration. Free-swimming experiments are performed to investigate the performance and maneuverability of the robot and correlate static thrust with terminal speed. This robotic platform is currently being used in ethorobotics research for investigating collective behavior of gregarious fish species and in educational fun-science activities for K-12 students.
The Immunoglobulin FactsBook (2001)

The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field. The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.
Active Immunization to 17β-Estradiol and Its Effects upon the Reproductive Cycle of the Rhesus Monkey (1974)

Fourteen rhesus monkeys were immunized to estradiol-17-hemisuccinyl-BSA. All 11 monkeys immunized with doses of 1.5 to 3.0 mg of the antigen developed antibodies to estradiol. In 7 of these animals, the antibody titers remained above 30& binding for the duration of the immunization. No titers were detected in 3 animals immunized with 4 to 6 mg of the antigen. Monkeys with persistently high antibody titers became anovulatory, as determined by low progestin levels and the absence of corpora lutea. The vaginal smears lost cyclicity and the intervals between uterine bleedings became irregular and lengthened. Average basal LH levels increasedsignificantly above controls but remained below those of castrated animals. Vaginal smears and uterine histology indicated a persistent estrogen stimulation. After a prolonged period of immunization, the ovaries were enlarged and multiple cystic follicles were present. Diethylstilbestrol, at doses of ISO to 750 μg in oil, induced a LH surge in 12 out of 18 experiments performed in monkeys with high antibody titers. In seven instances, this LH surge was followed by ovulation, as indicated by increased blood progestin levels. These results confirm previous experimental evidence for a causal relationship between the midcycle rise in estrogens and LH release in the primate (Endocrinology94: 765, 1974)