gebhart/patrepeval huggingface dataset:
Ground states of molecules. XXIX. MINDO/3 calculations of compounds containing third row elements (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGround states of molecules. XXIX. MINDO/3 calculations of compounds containing third row elementsMichael J. S. Dewar, Donald H. Lo, and Christopher A. RamsdenCite this: J. Am. Chem. Soc. 1975, 97, 6, 1311–1318Publication Date (Print):March 1, 1975Publication History Published online1 May 2002Published inissue 1 March 1975https://doi.org/10.1021/ja00839a005RIGHTS & PERMISSIONSArticle Views156Altmetric-Citations163LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (725 KB) Get e-Alerts Get e-Alerts
Introduction to the law of torts (2024)

Tort law is a dynamic area of Australian law, offering individuals the opportunity to seek legal remedies when their interests are infringed. Contemporary Australian Tort Law introduces the fundamentals of tort law in Australia today in an accessible, student-friendly way. This edition retains the logical coverage of key aspects of tort law and has been thoroughly updated to cover recent case law and legal developments. The chapter on defamation has been comprehensively updated to reflect recent amendments to uniform legislation and its application in common law. Self-assessment tools throughout the text encourage students to test and apply their knowledge of key concepts. These features include case questions and review questions throughout each chapter, as well as longer end-of-chapter hypothetical problems which consolidate students' application of key concepts to realistic contemporary scenarios. Written by a team of teaching experts, Contemporary Australian Tort Law is an engaging resource for students new to studying tort law.
Synergy between Two Active Sites of Human Complement Receptor Type 1 (CD35) in Complement Regulation: Implications for the Structure of the Classical Pathway C3 Convertase and Generation of More Potent Inhibitors (2005)

The extracellular domain of the complement receptor type 1 (CR1; CD35) consists entirely of 30 complement control protein repeats (CCPs). CR1 has two distinct functional sites, site 1 (CCPs 1-3) and two copies of site 2 (CCPs 8-10 and CCPs 15-17). In this report we further define the structural requirements for decay-accelerating activity (DAA) for the classical pathway (CP) C3 and C5 convertases and, using these results, generate more potent decay accelerators. Previously, we demonstrated that both sites 1 and 2, tandemly arranged, are required for efficient DAA for C5 convertases. We show that site 1 dissociates the CP C5 convertase, whereas the role of site 2 is to bind the C3b subunit. The intervening CCPs between two functional sites are required for optimal DAA, suggesting that a spatial orientation of the two sites is important. DAA for the CP C3 convertase is increased synergistically if two copies of site 1, particularly those carrying DAA-increasing mutations, are contained within one protein. DAA in such constructs may exceed that of long homologous repeat A (CCPs 1-7) by up to 58-fold. To explain this synergy, we propose a dimeric structure for the CP C3 convertase on cell surfaces. We also extended our previous studies of the amino acid requirements for DAA of site 1 and found that the CCP 1/CCP 2 junction is critical and that Phe82 may contact the C3 convertases. These observations increase our understanding of the mechanism of DAA. In addition, a more potent decay-accelerating form of CR1 was generated.
3D Shared Bus Architecture Using Inductive Coupling Interconnect (2015)

Attention has been focused on 3D chip stacking for reducing the semiconductor area per chip while maintaining the overall performance. By using inductive coupling wireless Thru-Chip Interface (TCI) in chip stack for a 3D multiprocessor, the replacement/addition/removing of chips is made possible using the inductive coupling wireless TCI in the chip stack for a 3D multiprocessor and thus, high flexibility is provided. A bus can be easily formed with the TCI by stacking duplex wired coils in the same place on the stacked chip. However, traditional static time division multiple access (STDMA) cannot make use of the potential bus bandwidth, while dynamic time division multiple access (DTDMA) requires a lot of coils that cannot be efficiently used for the control signals. We propose an asynchronous TDMA bus (A-TDMA bus) that uses the CSMA/CD protocol and a resonant synchronous TDMA bus (RS-TDMA bus) that uses a resonant synchronized clock and a look-ahead technique to improve the use of the bandwidth of a 3D shared bus. The results of a network simulation using the GEM5 simulator showed that the zero-load latency of both proposed methods was reduced by 29% in a four-chip stack and 50% in an eight-chip stack compared to that of STDMA. A full system simulation using GEM5 shows that the execution time of the proposed methods decreased by 6.5% in the four-chip stack and 17% in the eight-chip stack compared with that of STDMA.
Optimizing Pyrolysis of Sugar Carbons for Use as Anode Materials in Lithium‐Ion Batteries (1996)

Table sugar was pyrolyzed under various conditions. Carbons of pyrolyzed sugar demonstrated high capacity for Li intercalation, exceeding that of graphite. Experiments were carried out to search for optimal pyrolyzing conditions. The electrochemical behavior of these carbons was found to depend on the pyrolysis temperature, heating rate, argon gas flow rate, and morphology of the precursors. Pyrolysis of sugar was also carried out under vacuum, which is equivalent to a high argon gas flow. Carbons of pyrolyzed sugar under optimal conditions showed large reversible capacity, ≈650 mAh/g, small irreversible capacity, ⩽170 mAh/g, and small hysteresis between discharge and charge in carbon/Li metal electrochemical test cells. Pyrolyzed sugar carbons are therefore potential candidates as anode materials in Li‐ion batteries.
Bending experiment on pentacene field-effect transistors on plastic films (2005)

We have fabricated very flexible pentacene field-effect transistors with polyimide gate dielectric layers on plastic films with a mobility of 0.3cm2∕Vs and an on/off ratio of 105, and have measured their electrical properties under various compressive and tensile strains while changing the bending radius of the base plastic films systematically. We have found that the change in source-drain current with bending radius is reproducible and reversible when the bending radius is above 4.6mm, which corresponds to strains of ∼1.4±0.1%. Furthermore, the change in source-drain current does not depend on the direction of strain versus direction of current flow.
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells (1999)

Establishing cells with an exogenously introduced gene of interest under the inducible control of tetracycline (Tc) initially requires clonal cell lines stably expressing the tetracycline activator (tTA or rtTA). The originally described plasmid vectors expressing tTA/rtTA are driven by the cytomegalovirus (CMV) immediate early (IE) promoter-enhancer, known for its robust activity in a wide spectrum of cell types. While many reports testify to the utility and efficacy of this construct, instances of inexplicable failure to establish cell lines having inducible expression of the cDNA under study are encountered. Spontaneous extinction of CMV promoter activity in cells has been observed in a temporal and cell type-dependent manner. This could be a contributing factor in the failure to establish Tc-responsive cell lines. We here report that a change of the expression cassette to the human elongation factor-1alpha (EF-1alpha) promoter has permitted successful establishment of several inducible cell lines from diverse human tumor tissue origins. We interpret these results to imply that extinction of rtTA (or tTA) expression might be a significant factor in the lack of success in establishing Tc-inducible cell lines. Moreover, the present findings have general relevance to experiments requiring the use of stable cell lines.
Relative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice [see comments] (1990)

The relationship between the oral efficacy and the acute toxicity of hydroxypyridin-4-one iron chelators has been investigated to clarify structure-function relationships of these compounds in vivo and to identify compounds with the maximum therapeutic safety margin. By comparing 59Fe excretion following oral or intraperitoneal administration of increasing doses of each chelator to iron-overloaded mice, the most effective compounds have been identified. These have partition coefficients (Kpart) above 0.3 in the iron-free form with a trend of increasing oral efficacy with increasing Kpart values (r = .6). However, this is achieved at a cost of increasing acute toxicity, as shown by a linear correlation between 59Fe excretion increase per unit dose and 1/LD50 (r = .83). A sharp increase in the LD50 values is observed for compounds with Kpart values above 1.0, suggesting that such compounds are unlikely to possess a sufficient therapeutic safety margin. Below a Kpart of 1.0, acute toxicity is relatively independent of lipid solubility. All the compounds are less toxic by the oral route than by the intraperitoneal route, although iron excretion is not significantly different by these two routes. At least five compounds (CP51, CP94, CP93, CP96, and CP21) are more effective orally than the same dose of intraperitoneal desferrioxamine (DFO) (P less than or equal to .02) or orally administered L1(CP20) (P less than or equal to .02).
Aerodynamic flow acceleration using paraelectric and peristaltic electrohydrodynamic effects of a One Atmosphere Uniform Glow Discharge Plasma (2003)

The development of the One Atmosphere Uniform Glow Discharge Plasma has made it possible to cover the wings and fuselage of aircraft with a thin layer of glow discharge plasma at low energy cost. This plasma layer provides, through Lorentzian collisions, a purely electrohydrodynamic coupling between an electric field and the neutral gas in the boundary layer. This coupling is strong enough to cause aerodynamically significant acceleration and manipulation of the boundary layer and free stream flow, including re-attachment of flow to an airfoil at high angles of attack, and the peristaltic induction of neutral gas flow by a traveling electrostatic wave on the surface of a flat plate.
Left ventricular mass in diabetes-hypertension (1992)

This study was undertaken to identify whether diabetes mellitus (DM) accelerates the development of left ventricular hypertrophy (LVH) in hypertensive patients.Cardiac structure, systolic function, and hemodynamics were evaluated by two-dimensional M-mode echocardiography in diabetic and nondiabetic patients with essential hypertension.Patients with hypertension with and without DM had the same end-systolic and end-diastolic dimensions, cardiac output, total peripheral resistance, and ejection fraction. Diabetic hypertensive patients had greater interventricular septum (1.32 +/- 0.20 vs 1.07 +/- 0.20 cm) and posterior wall (1.20 +/- 0.20 vs 1.00 +/- 0.10 cm) thickness than did nondiabetic hypertensive patients. Consequently, left ventricular mass index was greater in patients with hypertension and DM than in those without DM (158 +/- 45 vs 113 +/- 20 g/m2). With the use of Devereux criteria for recognition of LVH (left ventricular mass index above 134 g/m2 in men and above 110 g/m2 in women), 72% of the diabetic patients had LVH, whereas only 32% of the nondiabetic patients had LVH. Left ventricular contractility, as reflected by the ratio of end-systolic wall stress to end-systolic volume index, was decreased in diabetic compared with nondiabetic hypertensive patients.The data suggest that DM accelerates the development of LVH in patients with essential hypertension independent of arterial pressure and, therefore, may contribute to the increased cardiovascular morbidity and mortality in patients with hypertension.
Paracetamol (Acetaminophen): mechanisms of action (2008)

Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors. Prostaglandin H(2) synthetase (PGHS) is the enzyme responsible for metabolism of arachidonic acid to the unstable PGH(2). The two major forms of this enzyme are the constitutive PGHS-1 and the inducible PGHS-2. PGHS comprises of two sites: a cyclooxygenase (COX) site and a peroxidase (POX) site. The conversion of arachidonic acid to PGG(2) is dependent on a tyrosine-385 radical at the COX site. Formation of a ferryl protoporphyrin IX radical cation from the reducing agent Fe(3+) at the POX site is essential for conversion of tyrosine-385 to its radical form. Paracetamol acts as a reducing cosubstrate on the POX site and lessens availability of the ferryl protoporphyrin IX radical cation. This effect can be reduced in the presence of hydroperoxide-generating lipoxygenase enzymes within the cell (peroxide tone) or by swamping the POX site with substrate such as PGG(2). Peroxide tone and swamping explain lack of peripheral analgesic effect, platelet effect, and anti-inflammatory effect by paracetamol. Alternatively, paracetamol effects may be mediated by an active metabolite (p-aminophenol). p-Aminophenol is conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through cannabinoid receptors. It may also work through PGHS, particularly in areas of the brain with high concentrations of fatty acid amide hydrolase.
Linear π-conjugated systems derivatized with C60-fullerene as molecular heterojunctions for organic photovoltaics (2005)

This tutorial review covers recent contributions in the area of linear pi-conjugated systems bound to fullerenes in view of their application as active materials in photovoltaic devices. The first part discusses the concepts of double-cable polymer and molecular hetero-junction and presents several examples of chemically or electrochemically synthesized C60-derivatized conjugated polymers. The second and main part of the article concerns the various classes of C60-derivatized pi-conjugated oligomers designed in view of their utilization in single-component photovoltaic devices. Thus, C60-containing pi-conjugated systems such as oligoarylenevinylenes, oligoaryleneethynylenes and oligothiophenes are discussed on the basis of the relationships between molecular structure, photophysical properties and performances of the derived photovoltaic devices. A brief last section presents some recent examples of surface-attached molecular hetero-junctions based on self-assembled monolayers and discusses possible routes for future research.
Seed-Specific Gene Activation Mediated by the Cre/lox Site-Specific Recombination System (1994)

The Cre/lox site-specific recombination system was used to activate a transgene in a tissue-specific manner. Cre-mediated activation of a beta-glucuronidase marker gene, by removal of a lox-bounded blocking fragment, allowed the visualization of the activation process. By using seed-specific promoters, the timing and efficiency of gene activation could be followed within the developing tobacco (Nicotiana tabacum) embryo. To serve as a basis for analyzing gene expression after-Cre-mediated activation, the timing and patterns of expression of the promoters of the genes encoding French bean (Phaseolus vulgaris) beta-phaseolin and the alpha' subunit of soybean (Glycine max) beta-conglycinin, as well as the cauliflower mosaic virus 35S promoter, were studied in developing transgenic tobacco embryos using the same visual marker. These seed-specific promoters were expressed earlier than anticipated. The 35S promoter was expressed earlier than the seed-specific promoters, but not in globular-stage embryos. Cre-mediated gene activation occurred approximately 1 d after promoter activation, based on developmental staging, and spread progressively throughout the embryo. The timing of gene activation was varied by altering Cre expression. Efficient Cre expression ultimately directed gene activation throughout the model tissue, whereas inefficient Cre expression resulted in mosaic tissue. Limited gene activation provides a system for cell lineage and developmental analyses.
Synthesis of remarkably stabilized metal nanostructures using polyoxometalates (2008)

This report reviews the state of the art as concerns the synthesis of metal nanostructures synthesized with polyoxometalates acting as both reducing and capping agents. Two main strategies appear in the literature: the reduced polyoxometalates, necessary for carrying out the process, can be obtained by photochemical reduction or be synthesized directly with reducing capabilities. This last strategy is recent and is shown to feature a “green chemistry-type” synthesis of metal nanostructures.
Full-color photosensitive glass (1978)

New polychromatic (full-color photosensitive) glasses are described in which the full color spectrum is developed by photochemical precipitation of subcolloidal silver too small to scatter light. The brilliant colors are shown to be due to selective light absorption by randomly oriented silver-containing particles having controlled anisotropic shapes. The color photographic process and its chemistry are outlined. Controlled anisotropy is due to photo-silver-nucleated growth of elongated NaF⋅ (Na,Ag) X pyramidal crystallites, concentration of AgX at the apex, and subsequent photoprecipitation of this silver. Resultant colors are primarily a function of exposure flux (intensity × time) employing ultraviolet light (300 nm). The colors can be semiquantitatively described from electromagnetic theory assuming ellipsoidal metal particles suspended in a transparent dielectric medium. An absorption band moves across the visible spectrum as a function of particle eccentricity. Polychromatic glasses can be made having transparency, opacity, or a mixed pattern through photonucleation control of halide crystallite growth, which governs light scattering. Colors may be developed in either clear or opal areas; they can be restricted to the surface of the glass or generated to great depth. The colors appear permanent at ambient temperature and exhibit good thermal stability.
RT97- and calcitonin gene-related peptide-like immunoreactivity in lumbar intervertebral discs and adjacent tissue from the rat. (1992)

The innervation of rat intervertebral disc and adjacent ligamentous tissue has been investigated using 2 antibodies, RT97 and anti-calcitonin gene-related peptide. Immunoreactivity to the peptide was found in many fibres throughout the long ligaments around the intervertebral discs and in the periosteum, especially associated with vascular channels entering the vertebral bodies. Few of the immunoreactive fibres entered the annular lamellae of the disc tissue. Most of those which terminated did so as fine fibres which lay close to, or in, the interlamellar spaces of the outer annulus fibrosus. Calcitonin gene-related peptide-like immunoreactivity was also found in more complex endings in the longitudinal ligaments and rarely within the annulus fibrosus. RT97-immunoreactivity was also present in the complex endings and associated fibres. Conversely, RT97-immunoreactivity was apparent only in a few fine filamentous fibre endings. This suggested that the majority of fine filamentous, or free, nerve endings were of an unmyelinated sensory origin. Alternatively, those endings of a more complex nature, which were RT97-immunoreactive, were of a myelinated sensory origin. No immunoreactivity to either antibody was seen in the inner annular or nuclear tissue. It was therefore concluded that the sensory innervation of the rat intervertebral disc has both myelinated and unmyelinated components, the latter being more extensive. Both types of innervation appear to be restricted to the outermost rings of the annulus fibrosus.
Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection (2011)

Staphylococcus aureus is a frequent cause for serious, chronic and therapy-refractive infections in spite of susceptibility to antibiotics in vitro. In chronic infections, altered bacterial phenotypes, such as small colony variants (SCVs), have been found. Yet, it is largely unclear whether the ability to interconvert from the wild-type to the SCV phenotype is only a rare clinical and/or just laboratory phenomenon or is essential to sustain an infection. Here, we performed different long-term in vitro and in vivo infection models with S. aureus and we show that viable bacteria can persist within host cells and/or tissues for several weeks. Persistence induced bacterial phenotypic diversity, including SCV phenotypes, accompanied by changes in virulence factor expression and auxotrophism. However, the recovered SCV phenotypes were highly dynamic and rapidly reverted to the fully virulent wild-type form when leaving the intracellular location and infecting new cells. Our findings demonstrate that bacterial phenotype switching is an integral part of the infection process that enables the bacteria to hide inside host cells, which can be a reservoir for chronic and therapy-refractive infections.
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2 (1997)

Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from ulcerative colitis (UC) patients have been described as reacting with proteins in the granules of human neutrophils such as cathepsin G and lactoferrin and with yet unidentified antigens. Here we report the existence of a new member of perinuclear ANCA (P-ANCA) in UC patients. In the previous study, we found that UC patients had a novel P-ANCA against neutrophil 28-kD protein. In this study, we purified the same antigens from HL-60 lysates by using reversed phase high-performance liquid chromatography, and revealed that the 28-kD antigen consisted of two different proteins. The N-terminus amino acids of these proteins are identical with those of high mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2. Immunoblotting analysis of human neutrophil lysates using rabbit anti-HMG1/2 antisera revealed a single band of 28 kD, and the 28-kD band detected by immunoblotting analysis using patient's serum IgG completely disappeared after preincubation with a mixture of HMG1 and HMG2. Furthermore, rabbit anti-HMG1/2 antisera showed a perinuclear staining pattern in indirect immunofluorescence studies using ethanol-fixed neutrophils. These data demonstrate that HMG1 and HMG2 are novel target antigens of P-ANCA. HMGI and HMG2 are distributed in the nuclei and cytoplasm of eukaryotic cells and act as transcription factors. Their intracellular localization and functions are distinct from those of the previously reported granular antigens of P-ANCA.