gebhart/patrepeval huggingface dataset:
Investigation of femtosecond laser assisted nano and microscale modifications in lithium niobate (2005)

A study of the physicochemical modifications at micro and nano scales as a result of femtosecond laser processing is essential to explore the viability of this process to write surface and subsurface structures in transparent media. To this end, scanning probe and transmission electron microscopy and spectroscopy techniques were used to study these modifications in lithium niobate. A variable power Ti:Sapphire system (800nm,300fs) was used to determine the ablation threshold of (110) lithium niobate, and to write these structures in the substrate for subsequent analysis. Higher processing energies were used to amplify the laser-induced effects for a clear understanding. Evidences of a number of simultaneously occurring mechanisms such as melting, ablation, and shockwave propagation are observed in the scanning electron microscope (SEM) micrographs. X-ray diffraction (XRD), Auger and electron dispersive spectroscopy (EDS) studies indicate loss of lithium and oxygen from the immediate surface of the processed region. Raman spectroscopy analysis indicates an unchanged chemical composition in the bulk, though at a loss of crystallinity. The surface and subsurface damage structures display a different nature of the amorphous and damaged material subregions, as observed in the respective transmission electron microscopy micrographs. A variation in oxygen counts is observed in the amorphous subregions, indicative of oxygen liberation and elemental segregation during the process. The oblate subsurface structure contains a void at the top, indicative of localized explosive melting and rapid quenching of the affected material. Thus, femtosecond laser writing produces different structures on the surface and the subsurface of the material. These results provide physicochemical insight towards writing chemically and spatially precise structures using femtosecond lasers, and will have direct implications in optical memory and waveguide writing and related applications.
Thalassemia in SouthEast Asia: problems and strategy for prevention and control. (1992)

In Southeast Asia alpha-thalassemia, beta-thalassemia, hemoglobin (Hb) E and Hb Constant Spring are prevalent. The gene frequencies of alpha-thalassemia reach 30-40% in Northern Thailand and Laos. beta-Thalassemia gene frequencies vary between 1 and 9%. Hb E is the hallmark of Southeast Asia attaining a frequency of 50-60% at the junction of Thailand, Laos, and Cambodia. Hb Constant Spring gene frequencies vary between 1 and 8%. These abnormal genes in different combinations lead to over 60 different thalassemia syndromes. The four major thalassemic diseases are Hb Bart's hydrops fetalis (homozygous alpha-thalassemia 1), homozygous beta-thalassemia, beta-thalassemia/Hb E and Hb H diseases. The molecular basis of most of these abnormal genes have been recently described. Therefore, it is possible to set a strategy for prevention and control of thalassemia which includes population screening for heterozygotes, genetic counseling and fetal diagnosis with selective abortion of affected pregnancies.
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element (1989)

The expression of alpha (immediate-early) genes of cytomegalovirus is regulated via a complex enhancer that consists of several different repeat elements. We describe here the autoinduction of expression from the alpha promoter-enhancer by the most abundant alpha gene product, a 491-amino-acid nuclear phosphoprotein referred to as ie1. We defined the 18-base-pair repeat element within the alpha enhancer as the signal through which ie1 acts to regulate gene expression. This element contains an NF kappa B site that may play an important role in ie1 autoregulation. Our analysis, which relied on deletions through the enhancer as well as reconstitution of responsiveness to a promoter with synthetic 18-base-pair repeats, strongly implicated ie1 in the transcriptional transactivation of the alpha promoter through its enhancer.
Activation-Repolarization Coupling in the Normal Swine Endocardium (1997)

The spatial distribution of repolarization is dependent on the activation pattern. Repolarization dispersion in the healthy swine heart is relatively small as the result of tight coupling of the action potential duration to the activation process, assigning longer ARIs to sites activated earlier. This coupling reduces global and regional dispersion of repolarization and may serve as an important antiarrhythmic mechanism present in normal myocardium.
Flow-Mediated Dilation in 9- to 11-Year-Old Children (1997)

Low birth weight is associated with impaired endothelial function in childhood, a key early event in atherogenesis. Growth in utero may be associated with long-term changes in vascular function that are manifest by the first decade of life and that may influence the long-term risk of cardiovascular disease.
Magnetic trapping and self-assembly of multicomponent nanowires (2002)

Magnetic nanowires suspended in fluid solutions can be assembled and ordered by taking advantage of their large shape anisotropy. Magnetic manipulation and assembly techniques are demonstrated, using electrodeposited Ni nanowires, with diameter 350 nm and length 12 μm. Orienting suspended nanowires in a small magnetic field H≈10 G promotes self-assembly of continuous chains that can extend over several hundred μm. The dynamics of this process can be described quantitatively in terms of the interplay of magnetic forces and fluid drag at low Reynolds number. In addition, a new technique of magnetic trapping is described, by which a single magnetic nanowire can be captured between lithographically patterned magnetic microelectrodes. The use of three-segment Pt–Ni–Pt nanowires yields low resistance, Ohmic electrical contacts between the nanowires and the electrodes. This technique has potential for use in the fabrication and measurement of nanoscale magnetic devices.
Continuous ultrasonic degumming of crude soybean oil (1990)

Abstract Ultrasonic energy has been applied to continuous degumming for the efficient removal of phospholipids from crude soybean oil. The crude oil and water (2.0% by weight) were pumped through an ultrasonic processing cell, oil and hydrated gums were separated by centrifugation, and the recovered oil was vacuum bleached. The degummed and bleached oil had a residual phosphorus content of less than 10 ppm and was subsequently deacidified‐deodorized in all‐glass laboratory deodorization equipment. Odor and flavor evaluation indicated that the salad oil produced by the process of ultrasonic degumming/deodorization‐deacidification was equivalent in quality and stability to a conventionally processed salad oil.
Silicone Elastomer Implantation Cyclodialysis (1973)

Five eyes with severe secondary angleclosure glaucoma were operated upon using the silicone elastomer (Silastic) implantation cyclodialysis procedure. It was not possible to thereby significantly reduce the intraocular pressure except for one eye, which also underwent a cyclodiathermy. Microscopic examination of this eye and two other eyes revealed an inflammatory reaction surrounding the silicone elastomer that obliterated the connection between the anterior chamber and suprachoroidal space. The silicone elastomer implant cyclodialysis is not recommended for severe secondary angle-closure glaucoma.
THE TEST-RETEST RELIABILITY OF A STANDARDIZED NEUROCOGNITIVE AND NEUROPHYSIOLOGICAL TEST BATTERY: “NEUROMARKER” (2005)

NeuroMarker combines EEG and ERP measures with neurocognitive tests in a fully computerized and standardized testing system. It is designed for use across the lifespan and has a large normative database of over 1,000 subjects. This study was a preliminary evaluation of "NeuroMarker" in subjects spanning four decades. Twenty-one healthy subjects (12-57 years) were tested at baseline and four weeks later. From the "Neuromarker" battery, the authors analyzed EEG data (eyes open and closed) and ERPs elicited during auditory oddball (N100, P200, N200, P300) and working memory (P150, P300) tasks. Concomitant neuropsychological data, acquired using a touch-screen system, comprised measures of sensori-motor, attention, verbal, executive, and memory function. Test-retest data were examined using analyses of variance and correlational procedures (corrected for multiple comparisons), with parallel analyses of age. EEG data did not differ across sessions, and showed high test-retest reliability (.71-.95), particularly for theta and delta (>.85). ERP components also showed sound reliability, particularly for sites where components are maximal: fronto-central N100 (.76-.77), centro-parietal P300 (.78-.81) to oddball targets, N100 and P200 (.74-.86) to oddball non-targets, and P150 amplitude and latency (.84-.93) to working memory stimuli. Neuropsychological tests showed a similarly sound level of consistency (on average, .70), with the most consistent tests tapping simple motor function, estimated intelligence, switching of attention (Part 2), verbal interference response time and memory intrusions (.71-.89). Age and sex did not have a differential impact on reliability for EEG, ERP, or neuropsychology measures. These findings provide preliminary evidence that the "NeuroMarker" battery is reliable for test-retest assessments. The results suggest that the standardized approach has utility for providing sensitive clinical and treatment evaluations across age groups.
Review of the New Mechanistic-Empirical Pavement Design Guide - A Material Characterization Perspective (2005)

The characterization of pavement materials in the proposed mechanistic-empirical pavement design (MEPD) guide involves application of the dynamic modulus technique for asphalt concrete and the resilient modulus for unbound materials. To circumvent the need for conducting the mechanical test in lower design levels, predictive equations and correlations established with physical properties are used to estimate the mechanistic properties needed as input to the design software. This paper examines the simplifications incorporated in the MEPD and the accuracy expected from this alternative in comparison with the MEPD guide proposed approach involving the use of an empirical predictive equation.
The Influence of Myers-Briggs Personality Types on Blended Technologies Employed in Second Classroom (2015)

This paper briefly introduced different perception styles and learning preferentiality based on Myers-Briggs Type personality types and how instructors employ relative blended technologies to second language classroom to cultivate effective learning environment and positive attitudes and towards language learning.
High sensitivity mapping of methylated cytosines (1994)

An understanding of DNA methylation and its potential role in gene control during development, aging and cancer has been hampered by a lack of sensitive methods which can resolve exact methylation patterns from only small quantities of DNA. We have now developed a genomic sequencing technique which is capable of detecting every methylated cytosine on both strands of any target sequence, using DNA isolated from fewer than 100 cells. In this method, sodium bisulphite is used to convert cytosine residues to uracil residues in single-stranded DNA, under conditions whereby 5-methylcytosine remains non-reactive. The converted DNA is amplified with specific primers and sequenced. All the cytosine residues remaining in the sequence represent previously methylated cytosines in the genome. The work described has defined procedures that maximise the efficiency of denaturation, bisulphite conversion and amplification, to permit methylation mapping of single genes from small amounts of genomic DNA, readily available from germ cells and early developmental stages.
Requirement for a functional host cell autolytic enzyme system for lysis of Escherichia coli by bacteriophage phi X174 (1984)

Escherichia coli VC30 is a temperature-sensitive mutant which is defective in autolysis. Strain VC30 lyses at 30 degrees C when treated with beta-lactam antibiotics or D-cycloserine or when deprived of diaminiopimelic acid. The same treatments inhibit growth of the mutant at 42 degrees C but do not cause lysis. Strain VC30 was used here to investigate the mechanism of host cell lysis induced by bacteriophage phi X 174. Strain VC30 was transformed with plasmid pUH12, which carries the cloned lysis gene (gene E) of phage phi X174 under the control of the lac operator-promoter, and with plasmid pMC7, which encodes the lac repressor to keep the E gene silent. Infection of strain VC30(pUH12)(pMC7) with phage phi X174 culminated in lysis at 30 degrees C. At 42 degrees C, intracellular phage development was normal, but lysis did not occur unless a temperature downshift to 30 degrees C was imposed. Similarly, induction of the cloned phi X174 gene E with isopropyl-beta-D-thiogalactoside resulted in lysis at 30 degrees C but not at 42 degrees C. Temperature downshift of the induced culture to 30 degrees C resulted in lysis even in the presence of chloramphenicol. These results indicate that host cell lysis by phage phi X174 is dependent on a functional cellular autolytic enzyme system.
Distance preserving run-length limited codes (1989)

A subset of the RLL (run-length limited) codes called distance preserving RLL codes is introduced. In addition to satisfying a run-length constraint, these codes have the property that the Hamming distance between any two encoder output sequences is at least as large as the Hamming distance between the corresponding encoder input sequences. Thus, when used in combination with a binary ECC code, a distance preserving RL code does not reduce the overall Hamming distance of the ECC/RLL combination to something below the Hamming distance of the ECC code alone. It is shown how distance preserving RLL codes can be used with binary convolutional codes to create combined ECC/RLL codes with the distance properties of the original convolutional code.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Q: Exploit Hardening Made Easy (2018)

Prior work has shown that return oriented programming (ROP) can be used to bypass W⊕X, a software defense that stops shellcode, by reusing instructions from large libraries such as libc. Modern operating systems have since enabled address randomization (ASLR), which randomizes the location of libc, making these techniques unusable in practice. However, modern ASLR implementations leave smaller amounts of executable code unrandomized and it has been unclear whether an attacker can use these small code fragments to construct payloads in the general case. In this paper, we show defenses as currently deployed can be bypassed with new techniques for automatically creating ROP payloads from small amounts of unrandomized code. We propose using semantic program verification techniques for identifying the functionality of gadgets, and design a ROP compiler that is resistant to missing gadget types. To demonstrate our techniques, we build Q, an end-to-end system that automatically generates ROP payloads for a given binary. Q can produce payloads for 80% of Linux /usr/bin programs larger than 20KB. We also show that Q can automatically perform exploit hardening: given an exploit that crashes with defenses on, Q outputs an exploit that bypasses both W⊕X and ASLR. We show that Q can harden nine realworld Linux and Windows exploits, enabling an attacker to automatically bypass defenses as deployed by industry for those programs.
A Novel Potassium Sensing in Aqueous Media with a Synthetic Oligonucleotide Derivative. Fluorescence Resonance Energy Transfer Associated with Guanine Quartet−Potassium Ion Complex Formation (2002)

A novel potassium sensing oligonucleotide (PSO) was constructed by attaching fluorophores 6-FAM and 6-TAMRA to the 5'- and 3'-termini of d(GGG TTA GGG TTA GGG TTA GGG), respectively. The affinity of PSO for K+ was 43 000 times greater than that for Na+, high enough selectivity enabling quantitation of K+ specifically in the presence of excess Na+. Fluorescence resonance energy transfer (FRET) to 6-TAMRA from 6-FAM of PSO was observed only in the presence of K+. This phenomenon is based on the approximation of the two fluorophores upon formation of a guanine quartet mediated by K+. Furthermore, the fluorescent color of PSO changes from yellow to red upon formation of the complex, thereby enabling visualization of K+ in aqueous media.
The Stereochemistry of the Phosphonate Modification of the Wittig Reaction (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Stereochemistry of the Phosphonate Modification of the Wittig ReactionD. H. Wadsworth, O. E. Schupp III, E. J. Seus, and J. A. Ford Jr.Cite this: J. Org. Chem. 1965, 30, 3, 680–685Publication Date (Print):March 1, 1965Publication History Published online1 May 2002Published inissue 1 March 1965https://pubs.acs.org/doi/10.1021/jo01014a005https://doi.org/10.1021/jo01014a005research-articleACS PublicationsRequest reuse permissionsArticle Views1359Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Thioester Ligation Approach to Amphipathic Bicyclic Peptide Library (2001)

An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.
Use of pharmacokinetics in the coagulation factor treatment of patients with haemophilia (2005)

Dosing decisions for replacement coagulation factors in patients with haemophilia should be made on an individual patient basis, with the required dose dependent on factors including the clinical situation, the severity of the factor deficiency, and the location and extent of bleeding. Moreover, there is considerable variability in the pharmacokinetics of coagulation products that needs to be considered; in particular, with both factor (F) IX and FVIII products, there is considerable inter-patient variability in in vivo recovery and terminal half-life values. In the present report, we provide a practical guide to calculating and applying pharmacokinetic parameters relevant to the optimal dosing of coagulation products. We discuss the conduct of a pharmacokinetic study in an individual patient, how to calculate pharmacokinetic values from raw data and clinical situations where an individual pharmacokinetic study is helpful. We highlight the importance of considering an individual pharmacokinetic study in all patients starting a new coagulation product.
Geodesic Convolutional Neural Networks on Riemannian Manifolds (2015)

Feature descriptors play a crucial role in a wide range of geometry analysis and processing applications, including shape correspondence, retrieval, and segmentation. In this paper, we introduce Geodesic Convolutional Neural Networks (GCNN), a generalization of the convolutional neural networks (CNN) paradigm to non-Euclidean manifolds. Our construction is based on a local geodesic system of polar coordinates to extract "patches", which are then passed through a cascade of filters and linear and non-linear operators. The coefficients of the filters and linear combination weights are optimization variables that are learned to minimize a task-specific cost function. We use ShapeNet to learn invariant shape features, allowing to achieve state-of-the-art performance in problems such as shape description, retrieval, and correspondence.
Reproductive Management of Lactating Dairy Cows Using Synchronization of Ovulation (1997)

Lactating dairy cows have poor reproductive efficiency because of low fertility and low rates of estrus detection. To eliminate the dependence on detection of estrus, we have recently developed a timed artificial insemination (AI) protocol that synchronized the time of ovulation using GnRH and PGF2 alpha. The effectiveness of this protocol as a management tool was compared with standard reproductive management. Lactating dairy cows (n = 333) from three herds were randomly assigned at parturition to two groups. Control cows were managed according to the typical reproductive strategy of the farm that relied on detection of estrus, the a.m.-p.m. breeding rule, and periodic use of PGF2 alpha. Treated cows had timed AI after synchronization of ovulation with GnRH and PGF2 alpha. For both groups, the voluntary waiting period was 50 d postpartum. Pregnancy diagnosis was performed by ultrasound between 32 and 38 d post-AI. Nonpregnant cows were inseminated again using the original treatment until diagnosed as pregnant or until culled from the herd. Median days to first AI (54 vs. 83) and days open (99 vs. 118) were lower for treated cows than for control cows, respectively. Pregnancy rates for the first AI were similar (37% vs. 39%) for the two groups even though treated cows were bred at an earlier time postpartum. More treated cows than control cows were pregnant at 60 d (37% vs. 5%) and at 100 d (53% vs. 35%) after calving. Thus, this protocol allowed effective management of AI in lactating dairy cows without the need for estrus detection.
First‐trimester prenatal diagnosis of aspartylglucosaminuria (1989)

Fetal aspartylglucosaminuria (AGU) was studied during the first trimester of pregnancy in six at-risk pregnancies using chorionic villus samples. The activity of aspartylglucosaminidase (AGA) was high in five cases, indicating an unaffected fetus. This was confirmed through delivery of healthy newborns with a normal pattern of urinary oligosaccharides. Low enzyme activity in an uncultured biopsy specimen and in cultured amniotic fluid cells in one case demonstrated that the fetus was affected. The pregnancy was terminated and the prenatal diagnosis was confirmed by showing reduced AGA activity in cultured fibroblasts of the fetus.
Activation of a Plant Gene by T-DNA Tagging: Auxin-Independent Growth in Vitro (1992)

A transferred DNA (T-DNA) tagging vector with the potential to produce dominant mutations was used with cocultured Agrobacterium tumefaciens and protoplasts to tag genes involved in the action of the plant growth substance auxin. Transgenic calli were selected for their ability to grow in the absence of auxin in the culture media. From one experiment, 12 calli that displayed this phenotype were recovered, of which 11 were able to regenerate into plants. In one plant studied in detail, protoplast division in the absence of auxin genetically cosegregated with a single T-DNA insert. A messenger RNA encoded by a 6.4-kilobase sequence of plant genomic DNA rescued from the mutant is overexpressed relative to untransformed plants. The genomic DNA, as well as a cognate complementary DNA, once transfected into protoplasts promote growth and cell division in vitro in the absence of exogenously added auxin.