gebhart/patrepeval huggingface dataset:
Silicon dimethylamido complexes and ammonia as precursors for the atmospheric pressure chemical vapor deposition of silicon nitride thin films (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSilicon dimethylamido complexes and ammonia as precursors for the atmospheric pressure chemical vapor deposition of silicon nitride thin filmsRoy G. Gordon, David M. Hoffman, and Umar RiazCite this: Chem. Mater. 1990, 2, 5, 480–482Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/cm00011a002https://doi.org/10.1021/cm00011a002research-articleACS PublicationsRequest reuse permissionsArticle Views254Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cyclit‐Reaktionen, II1). Darstellung von Bausteinen zur Synthese carbocyclischer Furanose‐Analoga (1981)

Abstract Alle vier isomeren Hydroxycyclopentenmethanole 6a bis 9a sind duch Allylhydroxylierung der Epoxide 2 und 4 mit Phenylselenid gut zugänglich. Das Paar 8a und 9a wurde auf einem zweiten Weg aus 11 über 15 synthetisiert. 6a bis 9a sind zu carbocyclischen Furanosen funktionalisierbar, wie die Gewinnung von 20 zeigt. Aus den Dicarbonsäure‐diethylestern 23 und 33 sind Modelle für carbocyclische Ketofuranosen darstellbar.
Measles virus polypeptide‐specific antibody profile in multiple sclerosis (1990)

Elevated antibody (Ab) titers to measles virus (MV) is a frequent finding in MS. Although MV-Abs are synthesized intrathecally, it is not known whether this is due to polyclonal activation of B cells recruited from the blood, recognition of MV antigens within the CNS, or cross-reactivity with myelin antigens. This study examined these possibilities using purified MV polypeptides. We examined Ab reactivity to each polypeptide in serum and CSF from 21 MS patients, 5 with subacute sclerosing panencephalitis (SSPE), and 11 patients with other neurologic diseases (OND), and serum from 5 patients with acute MV infection and 11 normal controls. The serum of all subjects tested contained reactivity with MV and the 5 polypeptides. Of 21 MS patients, 20 had CSF reactivity with MV compared with 3/11 ONDs and 5/5 SSPE patients. Intrathecal MV-Ab synthesis was present in 11/21 MS patients, 5/5 SSPE, and in none of the ONDs. Nine of 21 MS patients had intrathecal synthesis of Ab to 2 MV polypeptides. Serum and CSF reactivity in MS patients was skewed towards the F polypeptide. The results are consistent with the concept of polyclonal B cell activation within the CNS, but the heightened response to F could also reflect cross-reactivity with a relevant antigen in MS.
Efficient maximal poisson-disk sampling (2011)

We solve the problem of generating a uniform Poisson-disk sampling that is both maximal and unbiased over bounded non-convex domains. To our knowledge this is the first provably correct algorithm with time and space dependent only on the number of points produced. Our method has two phases, both based on classical dart-throwing. The first phase uses a background grid of square cells to rapidly create an unbiased, near-maximal covering of the domain. The second phase completes the maximal covering by calculating the connected components of the remaining uncovered voids, and by using their geometry to efficiently place unbiased samples that cover them. The second phase converges quickly, overcoming a common difficulty in dart-throwing methods. The deterministic memory is O ( n ) and the expected running time is O ( n log n ), where n is the output size, the number of points in the final sample. Our serial implementation verifies that the log n dependence is minor, and nearly O ( n ) performance for both time and memory is achieved in practice. We also present a parallel implementation on GPUs to demonstrate the parallel-friendly nature of our method, which achieves 2.4x the performance of our serial version.
The excellent scalability of the RCAT(recess-channel-array-transistor) technology for sub-70nm DRAM feature size and beyond (2005)

The technology innovation for extending the RCAT structure to the sub-70nm DRAM is presented. The new technology overcomes the problems induced by shrinkage of the RCAT structure and meets the requirements for the next generation DRAMs, such as high speed and low power performance. The technology roadmap down to the 50nm DRAM feature size of the RCAT development is presented.
Helvetica Chimica Acta (2006)

Anthocephalusine A (1) and 3 beta-isodihydrocadambine 4-oxide (2) were isolated from the leaves of Anthocephalus chinensis (Rubiaceac), together with five known compounds. The structures were established by spectroscopic methods including 2D-NMR analyses.
Chemistry of thienopyridines. VIII. Substitution products derived from thieno[2,3‐b] pyridine 7‐oxide (1970)

Abstract Thieno[2,3‐ b ]pyridine (I) was concerted to the N ‐oxide (II, 53%) by means of hydrogen peroxide and acetic acid. Nitration of II in sulfuric acid gave 4‐nitrothieno[2,3‐ b ]pyridine 7‐oxide (III, 50%), while nitration in acetic acid formed the isomeric 5‐nitrothieno[2,3‐ b ]pyridine 7‐oxide (IV, 54%). Compounds III and IV were reduced to the corresponding 4‐ and 5‐aminothieno[2,3‐ b ]pyridines, respectively. Treatment of III with acetyl chloride gave 4‐chlorothieno‐[2,3‐ b ]pyridine 7‐oxide (XI, 81%), convertible in two steps to 4‐( N ‐substituted amino)thieno‐[2,3‐ b ]pyridines (especially of the 4‐dialkylaminoalkylamino type) for screening as potential antimalarial drugs. 4‐Aminothieno[2,3‐ b ]pyridine reacted with aromatic aldehydes to give Schiff's bases and other products. Mechanisms for some of the reactions are suggested. NMR spectral data are reported for various 4‐substituted thieno[2,3‐ b ]pyridine compounds.
Pityriasis rosea-like drug reaction to asenapine. (2013)

Pityriasis rosea (PR) is a relatively common, benign skin disease of unknown etiology. In rare cases, medications can induce a morphologically similar eruption. We present a case of a PR-like drug eruption caused by the atypical antipsychotic asenapine. The clinical presentation consisted of a rapidly progressive, disseminated, and severely pruritic dermatitis comprised of ovoid, scaly, pink-violaceous plaques. The initial histopathologic specimen was consistent with PR, but upon re-sampling a week later, the findings favored a drug eruption. PR-like drug eruptions, though rare, can occur in response to a wide variety of medications. Because the findings may be only subtly different than those of typical PR, careful clinical and histopathological correlation must be sought. To our knowledge, this is the first reported case of a PR-like drug eruption to asenapine.
Effects of Joining Conditions on Joint Strength of Cu/Cu Joint Using Cu Nanoparticle Paste (2010)

High-temperature bonding, or joining, is a key technology for electronic component assembly and other hightemperature applications. Recently, focusing on the sintering behavior of nanoparticles, the joining process using a nanoparticle paste has been proposed as an alternative to soldering for high-temperature applications. In this study, Cu nanoparticle paste was used to join two Cu discs, and the effect of joining conditions on the joint strength of the Cu-to-Cu joint was investigated. Joining using Cu nanoparticle paste was successfully achieved, but the effect of joining conditions such as heating temperature and joining atmosphere on joint strength of the Cu-to-Cu joint was significant.
Noise Propagation in Gene Networks (2005)

Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits. To quantify how noise propagates through gene networks, we measured expression correlations between genes in single cells. We found that noise in a gene was determined by its intrinsic fluctuations, transmitted noise from upstream genes, and global noise affecting all genes. A model was developed that explains the complex behavior exhibited by the correlations and reveals the dominant noise sources. The model successfully predicts the correlations as the network is systematically perturbed. This approach provides a step toward understanding and manipulating noise propagation in more complex gene networks.
FTY720 attenuates accumulation of EMAP‐II+ and MHC‐II+ monocytes in early lesions of rat traumatic brain injury (2007)

FTY720 (Fingolimod) is a novel type of immunosuppressive agent inhibiting lymphocyte egress from secondary lymphoid tissues thereby causing peripheral lymphopenia. FTY720 can inhibit macrophage infiltration into inflammatory lesions under pathological conditions. FTY720 has been clinically evaluated for prophylaxis of allograft rejection and treatment of multiple sclerosis, showing promising immunosuppressive effects. A robust inflammatory response after traumatic brain injury (TBI) plays an important role in the secondary or delayed injuries of TBI. Here we have investigated by immunohistochemistry in a rat TBI model the effects of FTY720 on early cell accumulation into the inflammatory tissue response and on expression of major histo-compatibility complex class II (MHC-II) and endothelial-monocyte activating polypeptide II (EMAP-II). Accumulation of MHC-II(+) or EMAP-II(+) cells became significant 1 day after injury and continuously increased during the early time periods. Further, double-staining experiments confirmed that the major cellular sources of MHC-II were reactive macrophages, however MHC-II(+) cells only constituted a small subpopulation of reactive macrophages. Immediately after TBI, peripheral administration of FTY720 (1 mg/kg in 1 mL saline, every second day) significantly attenuated the accumulation of MHC-II(+) macrophages from Day 1 to 4 and significantly attenuated the accumulation of EMAP-II(+) macrophages/microglia at Day 4. Our findings show that FTY720 attenuates early accumulation of EMAP-II(+) and MHC-II(+) reactive monocytes following TBI, indicating that FTY720 might be a drug candidate to inhibit brain inflammatory reaction following TBI.
Towards de novo synthesis of structure-defined oligosaccharides with heparan sulfate biosynthetic enzymes (2019)

Heparan sulfate (HS), a highly sulfated polysaccharide, plays fundamental roles in a wide range of physiological and pathophysiological processes. The specific structure of HS determines its biological function. Various HS biosynthetic enzymes dictate the final structure of HS products. As an attractive target for medical and pharmaceutical research, synthesis of structurally defined HS oligosaccharides is one of the major challenges in the field of glycobiology. Enzymatic synthesis of HS represents a valuable complementary approach to chemical synthesis. The access to the unsulfated, unepimerized HS backbones is an essential step towards enzymatic synthesis of HS. In this research, we developed a chemoenzymatic approach for de novo synthesis of HS backbones with two bacterial glycosyltransferase, KfiA and PmHS2. KfiA is an N-acetylglucosaminyltransferase in Escherichia coli strain K5, while PmHS2 is a bifunctional enzyme with both N-acetylglucosaminyltransferase and D-glucuronyltransferase in Pasteurella multocida Types A, D, and F. Both of the recombinant proteins were prepared in large quantities. Characterization of KfiA reveals that its enzymatic activity is independent of the size of the acceptor substrates but a particular structure in the natural donor UDP-N-acetylglucosamine is required to bind KfiA. UDP-N-trifluoroacetylglucosamine, a derivative of UDP-N-acetylglucosamine, was recognized by KfiA and employed to synthesize unnatural HS backbones containing N-trifluoroacetylglucosamine residues. The synthesized oligosaccharides range from trisaccharide to undecasaccharide with a yield of 100 [mu]g to milligram scales. The controlled N-sulfation on HS backbones was achieved by selective removal of N-trifluoroacetyl groups and a subsequent N-sulfation with N-sulfotransferase. The synthesized octasaccharide backbone with defined N-sulfation was further modified with a collection of HS biosynthetic enzymes and yielded a bioactive octasaccharide binding to antithrombin. The results of this study open a new approach for the de novo synthesis of structure-defined HS oligosaccharides.
Intratumoral vaccination with vaccinia-expressed tumor antigen and granulocyte macrophage colony-stimulating factor overcomes immunological ignorance to tumor antigen. (2003)

Using a murine transitional cell carcinoma tumor model, MB49, which naturally expresses the male antigen HY, we evaluated whether tumor ignorance as determined by lack of a systemic immune response could be overcome by immunization with vaccinia expressed tumor antigen and granulocyte macrophage colony-stimulating factor. Systemic tumor ignorance of MB49 was demonstrated by the lack of a splenic HY-specific CTL response in MB49-bearing female mice. In contrast, we demonstrated HY-specific CTL priming in the draining lymph nodes. MB49-bearing female B6 mice were immunized with VVHY+VVGMCSF intratumorally or in the contralateral flank. Intratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generated splenic HY-specific CD8 CTLs, whereas immunization with the combination in the contralateral flank or single agents given intratumorally failed to yield a splenic response. Purified male T cells injected intratumorally, as a source of HY antigen, also generated a HY-specific response, whereas contralateral immunizations did not. These finding expand the understanding of tumor immunological ignorance and support intratumoral vaccination as a strategy for immunotherapy of established tumors.
SOLVENT USERS LOOK TO REPLACE NMP (2008)

RETURN TO ISSUEPREVNewsNEXTSOLVENT USERS LOOK TO REPLACE NMPN-METHYLPYRROLIDONE enabled environmentally friendlier products, but now it has toxicity problemsMARC REISCHCite this: Chem. Eng. News 2008, 86, 29, 32Publication Date (Print):July 21, 2008Publication History Published online14 November 2010Published inissue 21 July 2008https://pubs.acs.org/doi/10.1021/cen-v086n029.p032https://doi.org/10.1021/cen-v086n029.p032newsACS PublicationsCopyright © 2008 AMERICAN CHEMICAL SOCIETYArticle Views325Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Coating materials,Organic polymers,Solvents Get e-Alerts
Positive patch test reactions to oxidized limonene: exposure and relevance (2014)

Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.
Construct validity in psychological tests. (1955)

Validation of psychological tests has not yet been adequately conceptualized, as the APA Committee on Psychological Tests learned when it undertook (1950-54) to specify what qualities should be investigated before a test is published. In order to make coherent recommendations the Committee found it necessary to distinguish four types of validity, established by different types of research and requiring different interpretation. The chief innovation in the Committee's report was the term construct validity.[2] This idea was first formulated by a subcommittee (Meehl and R. C. Challman) studying how proposed recommendations would apply to projective techniques, and later modified and clarified by the entire Committee (Bordin, Challman, Conrad, Humphreys, Super, and the present writers). The statements agreed upon by the Committee (and by committees of two other associations) were published in the Technical Recommendations (59). The present interpretation of construct validity is not official and deals with some areas where the Committee would probably not be unanimous. The present writers are solely responsible for this attempt to explain the concept and elaborate its implications.
Mobile trunked radio system design and simulation (2002)

The fundamentals of trunked land mobile radio systems are examined. Many novel resource allocation methods have been examined to meet the unique needs of this service. These assignment algorithms are based on radio unit registration, user group talk zone requirements, and the channel availability. Computer simulation has been used to support this resource allocation method design. In particular, a discrete-event model of a wide area dynamic site assignment based trunked radio system is described. Simulation results are presented for an example comparing the performance of a particular trunking system using the forced vs. dynamic critical assignment method. The example system is to support 7777 radio users across 25 base sites.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Distribution ofLegionellaSpecies and Serogroups Isolated by Culture in Patients with Sporadic Community‐Acquired Legionellosis: An International Collaborative Survey (2002)

This international collaborative survey identified culture-confirmed legionellosis in 508 patients with sporadic community-acquired legionellosis. Legionella pneumophila constituted 91.5% of the isolates. Serogroup 1 was the predominant serogroup (84.2%), and serogroups 2-13 (7.4%) accounted for the remaining serogroups. The Legionella species most commonly isolated were L. longbeachae (3.9%) and L. bozemanii (2.4%), followed by L. micdadei, L. dumoffii, L. feeleii, L. wadsworthii, and L. anisa (2.2% combined). L. longbeachae constituted 30.4% of the community-acquired Legionella isolates in Australia and New Zealand.
The increased potency of cross-linked lymphocyte function-associated antigen-3 (LFA-3) multimers is a direct consequence of changes in valency. (1991)

We have used chemically cross-linked dimers, trimers, and tetramers of lymphocyte function-associated antigen-3 (LFA-3) to study the role of multivalency in the interaction of the protein with its receptor, CD2. The cross-linked adducts showed enhanced activity in systems where LFA-3 has been shown to (i) block LFA-3/CD2 interactions in a rosetting assay and (ii) provide through the CD2 on peripheral blood lymphocytes a trigger for T-cell proliferation. The level of increase was directly related to the valency state of the multimers. In the rosetting assay, the dimers, trimers, and tetramers, by weight, exhibited 15-, 150-, and 430-fold increases in activity over monomeric LFA-3. In the proliferation assay, the tetramer produced a 6-fold increase in thymidine incorporation at 0.06 micrograms/ml, the trimer was 100 times less active than the tetramer, and the dimer and monomer were inactive. The LFA-3 multimers were generated using a three-step cross-linking chemistry that was targeted at the carbohydrates on LFA-3. With this procedure over 60% of the starting protein was converted into multimers with no effect on function. The cross-linking approach should be applicable to other surface antigens, providing a simple method for analyzing multivalent interactions.
Low-loss GaInAsP buried-heterostructure optical waveguide branches and bends (1984)

Low-loss GaInAsP buried-heterostructure waveguide branches and bends have been demonstrated using a novel etch and liquid phase epitaxial regrowth technique. Branching losses as low as 0.4 dB at 1.3-μm wavelength for a 1° branch have been achieved. The measured waveguide propagation loss is ≤1.5 cm−1.
CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1 (2004)

CD26 is a T cell costimulatory molecule with dipeptidyl peptidase IV activity in its extracellular region. We previously reported that recombinant soluble CD26 enhanced T cell proliferation induced by the recall antigen tetanus toxoid (TT). However, the mechanism involved in this enhancement is not yet elucidated. We now demonstrate that CD26 binds Caveolin-1 on antigen-presenting cells, and that residues 201-211 of CD26 along with the serine catalytic site at residue 630 contribute to binding to caveolin-1 scaffolding domain. In addition, after CD26-caveolin-1 interaction on TT-loaded monocytes, caveolin-1 is phosphorylated, which links to activate NF-kappaB, followed by up-regulation of CD86. Finally, reduced caveolin-1 expression on monocytes inhibits CD26-mediated CD86 up-regulation and abrogates CD26 effect on TT-induced T cell proliferation. Taken together, these results strongly suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.
Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig-to-rat xenotransplantation. (1995)

The anticomplement agent K-76 COOH (K76), which mainly inhibits C5 activation, has been effectively used to mitigate experimental immune complex glomerulonephritis and ulcerative colitis.1,2 The effectiveness of K76, alone or in combination with FK 506 and cyclophosphamide (CP), in preventing xenograft rejection was studied using the hamster-to-rat and guinea pig-to-rat heart transplantation model.
Large scale multiplex PCR improves pathogen detection by DNA microarrays (2009)

Our data provide a proof of principle for the improvement of detection of pathogen DNA by microarray hybridization by using LSplex PCR.