gebhart/patrepeval huggingface dataset:
Monocarboxylate transporters in the central nervous system: distribution, regulation and function (2005)

Monocarboxylate transporters (MCTs) are proton-linked membrane carriers involved in the transport of monocarboxylates such as lactate, pyruvate, as well as ketone bodies. They belong to a larger family of transporters composed of 14 members in mammals based on sequence homologies. MCTs are found in various tissues including the brain where three isoforms, MCT1, MCT2 and MCT4, have been described. Each of these isoforms exhibits a distinct regional and cellular distribution in rodent brain. At the cellular level, MCT1 is expressed by endothelial cells of microvessels, by ependymocytes as well as by astrocytes. MCT4 expression appears to be specific for astrocytes. By contrast, the predominant neuronal monocarboxylate transporter is MCT2. Interestingly, part of MCT2 immunoreactivity is located at postsynaptic sites, suggesting a particular role of monocarboxylates and their transporters in synaptic transmission. In addition to variation in expression during development and upon nutritional modifications, new data indicate that MCT expression is regulated at the translational level by neurotransmitters. Understanding how transport of monocarboxylates is regulated could be of particular importance not only for neuroenergetics but also for areas such as functional brain imaging, regulation of food intake and glucose homeostasis, or for central nervous system disorders such as ischaemia and neurodegenerative diseases.
A W-Band Quasi-TEM Waveguide Using Electromagnetic Crystal (EMXT) Surfaces (2006)

A W-band (75-110 GHz) quasi-TEM square waveguide is designed and realized utilizing two-dimensional electromagnetic crystal (EMXT) surfaces as its boundary walls. Because EMXT surfaces provide special boundary conditions, the waveguide size is not limited by the typical cut-off frequency associated with a regular metallic waveguide and free space like wave propagation can be achieved for both polarizations. Both eigenmode and full-wave EM simulations verify the quasi-TEM propagation at the designed frequencies. The S-parameters of the EMXT waveguide in a WR-10 fixture is measured and low insertion loss that agrees with simulation is obtained. This type of waveguides may be useful for applications including spatial power combining, low loss interconnects, and packaging for millimeter wave systems
In Vivo Effect of Fluoride-substituted Apatite on Rat Bone (2005)

Different types of calcium phosphate compounds are commercially available for medical and dental applications as bone substitute materials. Biological apatites contain several kinds of minor elements such as carbonate (CO3), magnesium (Mg), and fluoride (F) in enamel, dentin, and bone. It has been shown that F ion and F-substituted apatite promoted osteoblast proliferation and inhibited osteoclast cell activity. The purpose of this study was to investigate the in vivo rat tibia activity on F-substituted apatite (FAp). Apatites of unsintered calcium deficient apatite (CDA), and FAps, with low, medium, and high F concentrations, were implanted in rat tibia for 1 and 2 weeks. Implanted tissues were embedded in paraffin blocks, stained with hematoxylin-eosin and histomorphometrically observed. Results showed that low F concentration induced better and faster new bone formation in vivo compared to CDA. Therefore the results suggested that F as a minor element in bone rendered a suitable effect on bone formation in vivo.
Effect of Mouthwashes of Variable NaF Concentration but Constant NaF Content on Oral Fluoride Retention (1994)

Previous work showed that oral fluoride levels increased with increasing applied F dose for both mouthwashes and dentifrices. This study aimed to determine whether the above dependence was related to applied fluoride concentration or applied fluoride amount. Ten adults mouthrinsed with aqueous NaF solutions of 1-10 ml, each of which contained 2.5 mg F, i.e. in the concentration range 250-2,500 ppm F. Subjects rinsed for 1 min and then spat out. Samples of mixed saliva were collected for 3 h afterwards, which were analysed for fluoride. Salivary fluoride clearance curves were obtained which could be fitted to a pharmacokinetic model involving processes ascribed to loss of fluoride from saliva by swallowing and to exchange of fluoride between saliva and an oral reservoir. Mean salivary fluoride concentrations increased significantly with increasing applied F concentration both within the first 3 h after single use and up to at least 18 h after regular daily use. These findings suggest that applied F concentration is a more important factor than applied F amount per se in determining the elevation of oral fluoride levels following topical fluoride use. This implies that application of a given F dose, in a smaller volume at higher concentration than the current norm, may increase efficacy without increasing the risk of adverse effects.
Kinetics of ionization of nitromethane and phenylnitromethane by amines and carboxylate ions in Me2SO-water mixtures. Evidence of ammonium ion-nitronate ion hydrogen bonded complex formation in Me2SO-rich solvent mixtures (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of ionization of nitromethane and phenylnitromethane by amines and carboxylate ions in Me2SO-water mixtures. Evidence of ammonium ion-nitronate ion hydrogen bonded complex formation in Me2SO-rich solvent mixturesClaude F. Bernasconi, Dahv A. V. Kliner, Amy S. Mullin, and Jiu Xiang NiCite this: J. Org. Chem. 1988, 53, 14, 3342–3351Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://doi.org/10.1021/jo00249a040RIGHTS & PERMISSIONSArticle Views207Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Interaction of the Mitotic Inhibitor Monastrol with Human Kinesin Eg5 (2002)

The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5 is reversibly inhibited by monastrol, a small cell-permeable molecule that causes cells to be arrested in mitosis. Both monomeric and dimeric Eg5 constructs have been examined in order to define the minimal monastrol binding domain on HsEg5. NMR relaxation experiments show that monastrol interacts with all of the Eg5 constructs used in this study. Enzymatic techniques indicate that monastrol partially inhibits Eg5 ATPase activity by binding directly to the motor domain. The binding is noncompetitive with respect to microtubules, indicating that monastrol does not interfere with the formation of the motor-MT complex. The binding is not competitive with respect to ATP. Both enzymology and in vivo assays show that the S enantiomer of monastrol is more active than the R enantiomer and racemic monastrol. Stopped-flow fluorometry indicates that monastrol inhibits ADP release by forming an Eg5-ADP-monastrol ternary complex. Monastrol reversibly inhibits the motility of human Eg5. Monastrol has no inhibitory effect on the following members of the kinesin superfamily: MC5 (Drosophila melanogaster Ncd), HK379 (H. sapiens conventional kinesin), DKH392 (D. melanogaster conventional kinesin), BimC1-428 (Aspergillus nidulans BimC), Klp15 (Caenorhabditis elegans C-terminal motor), or Nkin460GST (Neurospora crassa conventional kinesin).
Induction et régulation de la réponse IgE par le parasite trématode Schistosoma mansoni (1987)

Les anticorps de classe IgE produits lors de l'infection par Schistosoma mansoni jouent un role essentiel dans l'immunite anti-parasitaire. L'etude des antigenes cibles et inducteurs de cette reponse IgE protectrice s'avere donc d'un interet primordial et a fait l'objet de nos travaux.
Identification of Fibrinogen as a Key Anti-Apoptotic Factor in Human Fresh Frozen Plasma for Protecting Endothelial Cells In Vitro (2019)

Resuscitation with human fresh frozen plasma (FFP) in hemorrhagic shock (HS) patients is associated with improved clinical outcomes. Our group has demonstrated that the beneficial effect of FFP is due to its blockade on endothelial hyperpermeability, thereby improving vascular barrier function. The current study aimed to investigate HS-induced endothelial cell apoptosis, a potential major contributor to the endothelial hyperpermeability, and to determine the effect and the key components/factors of FFP on protecting endothelial cells from apoptosis. We first measured and demonstrated an increase in apoptotic endothelial microparticles (CD146AnnexinV) in patients in shock compared to normal subjects, indicating the induction of endothelial cell activation and apoptosis in shock patients. We then transfused HS rats with FFP and showed that FFP blocked HS-induced endothelial cell apoptosis in gut tissue. To identify the anti-apoptotic factors in FFP, we utilized high-performance liquid chromatography, fractionated FFP, and screened the fractions in vitro for the anti-apoptotic effects. We selected the most effective fractions, performed mass spectrometry, and identified fibrinogen as a potent anti-apoptotic factor. Taken together, our findings suggest that HS-induced endothelial apoptosis may constitute a major mechanism underlying the vascular hyperpermeability. Furthermore, the identified anti-apoptotic factor fibrinogen may contribute to the beneficial effects of FFP resuscitation, and therefore, may have therapeutic potential for HS.
High Weight Fraction Surfactant Solubilization of Single-Wall Carbon Nanotubes in Water (2003)

We report a simple process to solubilize high weight fraction single-wall carbon nanotubes in water by the nonspecific physical adsorption of sodium dodecylbenzene sulfonate. The diameter distribution of nanotubes in the dispersion, measured by atomic force microscopy, showed that even at 20 mg/mL ∼63 ± 5% of single-wall carbon nanotube bundles exfoliated into single tubes. A measure of the length distribution of the nanotubes showed that our dispersion technique reduced nanotube fragmentation.
Turning off sacral nerve stimulation does not affect gastric and small intestinal motility in patients treated for faecal incontinence (2012)

Turning off SNS for 1week did not affect gastric or small-intestinal motility patterns.
Progress in Optics (1987)

Front Cover; Progress in Optics; Copyright; Table of Contents; Preface; Chapter 1. Optical Pulse Propagation in Biological Media: Theory and Numerical Methods; 1. Introduction; 2. Light Scattering; 3. Photon Transport Equation; 4. Numerical Methods; 5. Concluding Remarks; References; Chapter 2. Manipulating Light Statesby Single-Photon Addition and Subtraction; 1. Introduction; 2. Single-Photon Operators for Manipulating Quantum Information; 3. Single-Photon Addition; 4. Single-Photon Subtraction; 5. Sequences and Superpositions of Single-Photon Operators; 6. Conclusions; 7. Acknowledgments
Structure of the Fully Modified Left-Handed Cyclohexene Nucleic Acid Sequence GTGTACAC (2008)

CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.
Enterocolitis in children with developmental disorders (2000)

A new variant of inflammatory bowel disease is present in this group of children with developmental disorders.
Applying parallel/distributed computing to advanced algebraic computations (2002)

PVM-based parallel/distributed computation tools have been designed, implemented, and applied to two important mathematical algorithms. The tools make PVM easier to use and applicable to a wider class of computations. The application shows how advanced algebraic algorithms can take advantage of modern parallel/distributed computing with the aid of such tools. The tools and interfaces described include PVM-ET (a set of enhancement tools for PVM), PvmJobs (a general bag of jobs library that works with any user created job structure in a master/slave paradigm), and SaclibPvm (a simple software package interfacing SACLIB to PVM). The ability to interface symbolic computing to PVM allows us to tackle the parallelization of the Grobner bases algorithm and the characteristic sets method, two very compute intensive algorithms important in algebraic computations. These algorithms, their parallelization, and experimental results are presented.
<title>Digital watermarking</title> (1996)

This paper presents a process able to mark digital pictures with an invisible and undetectable secret information, called the watermark. This process can be the basis of a complete copyright protection system. The process first step consists in producing a secret image. The first part of the secret resides in basic information that forms a binary image. That picture is then frequency modulated. The second part of the secret is precisely the frequencies of the carriers. Both secrets depend on the identity of the copyright owner and on the original picture contents. The obtained picture is called the stamp. The second step consists in modulating the amplitude of the stamp according to a masking criterion stemming from a model of human perception. That too theoretical criterion is corrected by means of morphological tools helping to locate in the picture the places where the criterion is supposed not to match. This is followed by the adaptation of the level of the stamp at that place. The so formed watermark is then added to the original to ensure its protection. That watermarking method allows the detection of watermarked pictures in a stream of digital images, only with the knowledge of the picture owner's secrets.
Statins and fracture risk. A systematic review (2007)

Current evidence does not support an effect of statins in preventing fractures given (i) the lack of association in randomized trials, (ii) the heterogeneity among observational studies, (iii) the potential residual confounding, and (iv) the potential publication bias.
Commensal bacteria in the gut: learning who our friends are (2004)

Progress in understanding the relation between commensal bacteria and human health is likely to promote the identification of new approaches to disease prevention and treatment.
Lymphocyte activation the coming of the protein tyrosine phosphatases (1998)

The molecular mechanisms of signal transduction have been at the focus of intense scientific research world-wide. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases is in its infancy, but is currently gathering momentum and is predicted to become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in lymphocyte activation.
A 450-MHz RISC microprocessor with enhanced instruction set and copper interconnect (1999)

This superscalar microprocessor is the first implementation of a 32-bit RISC architecture specification incorporating a single-instruction, multiple-data vector processing engine. Two instructions per cycle plus a branch can be dispatched to two of seven execution units in this microarchitecture designed for high execution performance, high memory bandwidth, and low power for desktop, embedded, and multiprocessing systems. The processor features an enhanced memory subsystem, 128-bit internal data buses for improved bandwidth, and 32-KB eight-way instruction/data caches. The integrated L2 tag and cache controller with a dedicated L2 bus interface supports L2 cache sizes of 512 KB, 1 MB, or 2 MB with two-way set associativity. At 450 MHz, and with a 2-MB L2 cache, this processor is estimated to have a floating-point and integer performance metric of 20 while dissipating only 7 W at 1.8 V. The 10.5 million transistor, 83-mm/sup 2/ die is fabricated in a 1.8-V, 0.20-/spl mu/m CMOS process with six layers of copper interconnect.
Pembrolizumab (2015)

The development of the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab and its approval in 2011 for the treatment of metastatic melanoma has heralded a new era in immuno-oncology. Subsequently, novel agents against the programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1) axis have shown significant activity in melanoma and a variety of other tumor types. Pembrolizumab was the first anti-PD-1 antibody to be approved by the US Food and Drug Administration for the treatment of patients with unresectable or metastatic melanoma with disease progression following ipilimumab, and if BRAF (V600) mutation positive, a BRAF inhibitor. Pembrolizumab has also received breakthrough status for the treatment of EGFR mutation-negative, ALK rearrangement-negative non-small cell lung cancer (NSCLC) that has progressed on or following platinum-based chemotherapy. There remain a number of pivotal trials in progress to further evaluate the optimal use of pembrolizumab alone and in combination for melanoma, NSCLC, and other tumor types. In this article, we review the efficacy and toxicity profile of pembrolizumab and evaluate its future development.
Galα(1,3)Gal, the Major Xenoantigen(s) Recognised in Pigs by Human Natural Antibodies (1994)

The transplantation of pig organs to humans (xenotransplantation) is now receiving serious consideration because of the shortage of human donors for organ transplants of kidney, liver and heart, and of islet cell transplantation for diabetes. The problem with such xenografts would be hyperacute rejection--mediated by natural antibodies in humans to pig antigens, complement fixation to endothelial cells, and the rapid onset of intravascular coagulation. It is now clear that the major target of the natural IgM and IgG antibodies is the terminal carbohydrate epitope Gal alpha(1,3)Gal, formed by the alpha 1,3galactosyl transferase, which places a terminal galactose residue in an alpha-linkage to another galactose. The alpha 1,3galactosyl transferase in the pig gives rise to very high endothelial cell expression of Gal alpha(1,3)Gal, a ready explanation for the hyperacute rejection of vascularized organs. In addition the parenchuma of liver and kidneys have high levels of Gal alpha-(1,3)Gal. These tissues will all fail in a pig-to-human transplant in what can now be precisely defined in terms of antigen and antibody. We have already made some suggestions for removal of anti-Gal alpha(1,3)Gal antibodies and if the procedure were technically feasible xenotransplantation could be attempted now, especially in patients doomed to a certain death because of the absence of a donor (especially for liver where ex vivo perfusion could be performed). However, the immune system is far from simple, as is shown by the healthy status of mice lacking MHC Class I, Class II or both Class I & II molecules. Perhaps the curtain is about to go up to reveal a new scene! Islets differ from the other tissues and may well not undergo acute antibody-mediated hyperacute rejection--it will be of interest to see how these fare in xenotransplantation models or even in patients. Again, normal individuals do not have anti-islet antibodies; but a proportion of diabetic patients do have such antibodies--whether these will cause hyperacute or acute rejection or are markers of immunity of T-cell type, remains to be seen. Whatever, the area is exciting, is progressing rapidly and, as indicated elsewhere, within a few years we should know whether modified pig tissue can be grafted to some patients. The isolation of the cDNA clone encoding the pig alpha 1,3 galactosyl transferase is an essential first step in the production of a transgenic pig lacking the alpha 1,3Galactosyltransferase and therefore the Gal alpha(1,3)Gal epitope, and such animals could serve as donor for human transplantation.
The Antiaggregating and Antithrombotic Activity of Clopidogrel Is Potentiated by Aspirin in Several Experimental Models in the Rabbit (1998)

It is unknown whether the addition of aspirin might increase both the efficacy and the potency of clopidogrel, a potent and selective ADP blocker. For that purpose, the efficacy of clopidogrel (1-20 mg/kg, p.o.) administered orally to rabbits alone or in combination with aspirin (0.1-10 mg/kg, p.o.) was determined in several experimental models. A potent synergistic effect of the clopidogrel/aspirin association was demonstrated with regard to collagen-induced platelet aggregation measured ex vivo. Similarly, aspirin potentiated the antithrombotic activity of clopidogrel measured with regard to experimental thrombosis induced by a silk thread or on stents placed in an arteriovenous shunt, thrombus formation following electrical stimulation of the rabbit carotid artery and with regard to 111In-labeled platelet deposition on a stent implanted in an arteriovenous shunt or on the subendothelium following air drying injury of the rabbit carotid artery. A similar potentiating effect of aspirin was obtained with regard to myointimal proliferation (restenosis) in the femoral arteries of atherosclerotic rabbits which occurred as a consequence of stent placement. The clopidogrel/aspirin combination showed only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. Such a combination may provide substantial protection against platelet aggregation leading to thrombotic occlusion at sites of endothelial injuries and coronary artery stenosis in humans.