gebhart/patrepeval huggingface dataset:
17-Desoxy estrogen analogs (1989)

A series of 17-substituted, 17-desoxyestratrienes have been synthesized and tested as potential postcoital antifertility agents. Estrogen-relative binding affinities were determined, in vivo assays for estrogenic and postcoital antifertility activity were conducted in rats, and selected candidate compounds were further tested for estrogenic activity in monkeys. In the rat, the 17-desoxyestratriene derivatives 8a, 8b, and 30 have shown low estrogenic activity while retaining potent antifertility activity. Structural modifications at the outset included a variety of 17-substituents and an omission of the 17-oxygen functionality, which was previously thought to be necessary for potent activity. The 17 beta-ethyl side chain exhibited the greatest antifertility activity with the largest separation ratio to estrogenicity. Nuclear modification of 17-desoxyethylestrane derivatives at positions 7 and 11 further increased the desired separation of activity, with the 11-hydroxy moiety enhancing separation more than other features.
The What-and-Where Filter (1998)

The What-and-Where filter forms part of a neural network architecture for spatial mapping, object recognition, and image understanding. The Where filter responds to an image figure that has been separated from its background. It generates a spatial map whose cell activations simultaneously represent the position, orientation, and size of all the figures in a scene (where they are). This spatial map may be used to direct spatially localized attention to these image features. A multiscale array of oriented detectors, followed by competitive and interpolative interactions between position, orientation, and size scales, is used to define the Where filter. This analysis discloses several issues that need to be dealt with by a spatial mapping system that is based upon oriented filters, such as the role of cliff filters with and without normalization, the double peak problem of maximum orientation across size scale, and the different self-similar interpolation properties across orientation than across size scale. Several computationally efficient Where filters are proposed. The Where filter may be used for parallel transformation of multiple image figures into invariant representations that are insensitive to the figures' original position, orientation, and size. These invariant figural representations form part of a system devoted to attentive object learning and recognition (what it is). Unlike some alternative models where serial search for a target occurs, a What and Where representation can be used to rapidly search in parallel for a desired target in a scene. Such a representation can also be used to learn multidimensional representations of objects and their spatial relationships for purposes of image understanding. The What-and-Where filter is inspired by neurobiological data showing that a Where processing stream in the cerebral cortex is used for attentive spatial localization and orientation, whereas a What processing stream is used for attentive object learning and recognition.
Actinomyces europaeusIsolated from a Breast Abscess in a Penicillin-Allergic Patient (2018)

This is a case of <i>Actinomyces europaeus</i> in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature describing nonpenicillin treatment options. A 69-year-old woman presented acutely with a breast abscess which was managed with incision and drainage and antibiotic therapy to good response. 21 days after presentation, <i>Actinomyces</i> were grown from the culture of pus, so the patient was recalled and more rigorous treatment and follow-up were initiated. The penicillin allergy led to difficulty in the identification of an appropriate antimicrobial agent that was also logistically feasible to be given on an outpatient IV basis. IV tigecycline followed by oral clarithromycin was found to be effective treatment.
The research and development for Advanced Whole Body Hyperthermia (2002)

We have developed a method of heating and control body temperature in Whole Body Hyperthermia (WBH). Tumor cells can be demaged at high temperature and it is also efficient to prevent metastasis of advanced cancer. It is important for the advanced WBH to control a vasoconstriction that the deteriorate of heat transfer efficiency in human body and to reduce the stimulus of skin by heating. As the basic verifications, we identified the reaction of body temperature under WBH as five phases and we tried the reduction of WBH-period by pre heating and cyclic heating by adjustment of the combination of heat conductive and radiant.
Preparation and characterization of γ-AlOOH nanotubes and nanorods (2005)

A solution-phase reaction under hydrothermal conditions at relatively low temperature is first put forward for the preparation of γ-AlOOH nanotubes and nanorods, on the basis of the possible strategy that the 2D framework structure of γ-AlOOH containing lamellae could provide orientation for the growth of 1D nanostructures. X-ray diffraction (XRD) patterns, transmission electronic microscope (TEM) images, Fourier transform infrared (FTIR) spectra, and photoluminescence (PL) spectra were used to characterize the products. A possible formation mechanism of nanotubes and nanorods from lamellar precursor is proposed.
Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa (1996)

Peripheral blood monocytes are recruited to the inflamed mucosa of inflammatory bowel disease but the specific chemotactic signals responsible for their attraction are not known. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine with potent monocyte attracting and activating properties and the aim of this study was to examine its expression and production in inflammatory bowel disease. In situ hybridization demonstrated mRNA for MCP-1 in macrophages, some of which had been recently recruited from the circulation as demonstrated by their co-expression of the monocyte marker CD 14, as well as in smooth muscle and endothelial cells in inflamed mucosa. Immunohistochemical studies showed a corresponding distribution of MCP-1 protein production by macrophages, smooth muscle, and endothelial cells. By contrast minimal MCP-1 mRNA expression and protein were found in histologically normal mucosa. Macrophages isolated from surgically resected inflammatory bowel disease colons and examined by Northern analysis expressed MCP-1 mRNA significantly more frequently (15/24 vs. 0/19, P< 0.0001) than macrophages from histologically normal mucosa from colon cancer resections. Blood monocytes stimulated by lipopolysaccharide and treated with hydrocortisone, 5-aminosalicylic acid, or cyclosporin A showed reduced MCP-1 expression and production in the presence of these agents. This study demonstrates increased expression of MCP-1 mRNA and protein and cells of origin of MCP-1 in inflamed intestinal mucosa. Together with the demonstrated influence of therapeutic agents on monocyte MCP-1 production the findings suggest a role for MCP-1 in monocyte attraction to the mucosal lesion of inflammatory bowel disease.
Mitochondriopathies (2004)

Mitochondriopathies (MCPs) are either due to sporadic or inherited mutations in nuclear or mitochondrial DNA located genes (primary MCPs), or due to exogenous factors (secondary MCPs). MCPs usually show a chronic, slowly progressive course and present with multiorgan involvement with varying onset between birth and late adulthood. Although several proteins with signalling, assembling, transport, enzymatic function can be impaired in MCP, most frequently the activity of the respiratory chain (RC) protein complexes is primarily or secondarily affected, leading to impaired oxygen utilization and reduced energy production. MCPs represent a diagnostic challenge because of their wide variation in presentation and course. Systems frequently affected in MCP are the peripheral nervous system (myopathy, polyneuropathy, lactacidosis), brain (leucencephalopathy, calcifications, stroke-like episodes, atrophy with dementia, epilepsy, upper motor neuron signs, ataxia, extrapyramidal manifestations, fatigue), endocrinium (short stature, hyperhidrosis, diabetes, hyperlipidaemia, hypogonadism, amenorrhoea, delayed puberty), heart (impulse generation or conduction defects, cardiomyopathy, left ventricular non-compaction heart failure), eyes (cataract, glaucoma, pigmentary retinopathy, optic atrophy), ears (deafness, tinnitus, peripheral vertigo), guts (dysphagia, vomiting, diarrhoea, hepatopathy, pseudo-obstruction, pancreatitis, pancreas insufficiency), kidney (renal failure, cysts) and bone marrow (sideroblastic anaemia). Apart from well-recognized syndromes, MCP should be considered in any patient with unexplained progressive multisystem disorder. Although there is actually no specific therapy and cure for MCP, many secondary problems require specific treatment. The rapidly increasing understanding of the pathophysiological background of MCPs may further facilitate the diagnostic approach and open perspectives to future, possibly causative therapies.
The PAPR Reduction in OFDM System with the Help of Signal Mapping Scheme (2007)

The non-linear distortion caused by high peak-to-average power ratio (PAPR) of transmitted signal is a major drawback in the OFDM systems. In this paper, the proposed PAPR reduction scheme is to choose the corresponding symbol patterns with a low PAPR in the ex- panded signal space. However, the scheme has a high complexity for the selection of symbol pattern with the smallest signal power in a larger expanded signal space. The scheme could be realized as a signal mapping from the original information symbols to the corresponding patterns. With the selection of the corresponded symbol patterns, the PAPR could be greatly reduced. Ac- cording to the simulation results with the proposed scheme, while the length of the data frame is 16 and the signal expansion with adding 1 bit and 2 bits, the PAPR changing rate could be 20 percents and 16 percents of the original PAPA, respectively. However, there is no prominent im- provement on PAPR reduction with more than 8 bits for using the signal expansion scheme.
Data placement for scientific applications in distributed environments (2007)

Scientific applications often perform complex computational analyses that consume and produce large data sets. We are concerned with data placement policies that distribute data in ways that are advantageous for application execution, for example, by placing data sets so that they may be staged into or out of computations efficiently or by replicating them for improved performance and reliability. In particular, we propose to study the relationship between data placement services and workflow management systems. In this paper, we explore the interactions between two services used in large-scale science today. We evaluate the benefits of prestaging data using the Data Replication Service versus using the native data stage-in mechanisms of the Pegasus workflow management system. We use the astronomy application, Montage, for our experiments and modify it to study the effect of input data size on the benefits of data prestaging. As the size of input data sets increases, prestaging using a data placement service can significantly improve the performance of the overall analysis.
Sign- and Magnitude-Tunable Coupler for Superconducting Flux Qubits (2007)

We experimentally confirm the functionality of a coupling element for flux-based superconducting qubits, with a coupling strength $J$ whose sign and magnitude can be tuned in situ. To measure the effective $J$, the ground state of a coupled two-qubit system has been mapped as a function of the local magnetic fields applied to each qubit. The state of the system is determined by directly reading out the individual qubits while tunneling is suppressed. These measurements demonstrate that $J$ can be tuned from antiferromagnetic through zero to ferromagnetic.
Prospective Belgian study of neurodegenerative and vascular dementia: APOE genotype effects (2003)

This study confirmed the risk association between APOE epsilon 4 and AD. The observation that APOE epsilon 4 is associated with mixed dementia reflected the role of AD in the aetiopathogenesis of this condition. Although MCI is an aetiologically heterogeneous syndrome, the increased APOE epsilon 4 frequencies indicated that a large proportion of the MCI patients included in the study might be predisposed to develop AD.
Identification of a Highly Immunogenic HLA-A*01-Binding T Cell Epitope of WT1 (2006)

In this study, a modified reverse immunology strategy was employed to identify a first immunogenic HLA-A*01-restricted T cell epitope of the tumor antigen WT1, which is of considerable interest for use in vaccination trials.
Enzymic asymmetric hydroxylation of pentadienols using soybean lipoxygenase (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic asymmetric hydroxylation of pentadienols using soybean lipoxygenaseP. Zhang and Keith S. KylerCite this: J. Am. Chem. Soc. 1989, 111, 26, 9241–9242Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://pubs.acs.org/doi/10.1021/ja00208a024https://doi.org/10.1021/ja00208a024research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Glycated Polyelectrolyte Multilayer Films:  Differential Adhesion of Primary versus Tumor Cells (2006)

Glycated polymers have already been widely employed for cell transfection studies, as cells possess specific lectins. However, up to now, these glycated polymers have barely been investigated for their cell adhesive properties, save macrophages. In this work, we use polyelectrolyte multilayer films made of poly(L-lysine) and poly(L-glutamic) acid as polymeric substrates to investigate the role of sugar molecules (e.g., mannose and lactose) on the adhesion of primary cells as compared to that of a tumor cell line. The glycated polymeric films were compared to ungrafted and chemically cross-linked films, which are known to present opposite adhesive properties. A differential adhesion could be evidenced on mannose grafted films: primary chondrocytes adhere and proliferate well on these films, whereas chondrosarcoma cells do not grow well. Although present, the effect of lactose on cell adhesion was much less important. This adhesion, mediated by glycated polymers, appears to be specific. These results show that it is possible to use glycated polyelectrolytes not only as nonviral vectors but also as cell adhesive substrates.
In Vivo Performance of a Transcutaneous Energy Transmission System with the Penn State Motor Driven Ventricular Assist Device (1989)

A transcutaneous energy transmission system (TETS) has been used to power the Penn State motor driven ventricular assist device in nine calf experiments, for a total of 316 days of cumulative in vivo experience. This is seen as an important step toward a completely implantable ventricular assist system and total artificial heart. The TETS converts an external 12 volt DC source via inductive coupling to a regulated 14 volt output voltage for use by the motor controller. A maximum output power of 70 watts is available. In calf experiments, the TETS output power averaged between 8 and 12 watts. The motor controller was not implanted in these experiments, awaiting further development of the miniaturized electronics. The TETS output was returned percutaneously to the external motor controller, allowing the TETS output to be monitored directly. System efficiency, from DC source to DC output, and including losses in 12 feet of cable, ranged from 55% to 70%, depending upon supply voltage, motor load, and degree of coil coupling. The subcutaneous coil was well tolerated, demonstrating only temporary, mild, superficial induration.
Towards Distributed Service Discovery in Pervasive Computing Environments (2005)

The paper proposes a novel distributed service discovery protocol for pervasive environments. The protocol is based on the concepts of peer-to-peer caching of service advertisements and group-based intelligent forwarding of service requests. It does not require a service to be registered with a registry or lookup server. Services are described using the Web Ontology Language (OWL). We exploit the semantic class/subClass hierarchy of OWL to describe service groups and use this semantic information to selectively forward service requests. OWL-based service description also enables increased flexibility in service matching. We present simulation results that show that our protocol achieves increased efficiency in discovering services (compared to traditional broadcast-based mechanisms) by efficiently utilizing bandwidth via controlled forwarding of service requests.
A Dynamic Programming Approach for Product Selection and Supermarket Shelf-Space Allocation (1986)

A dynamic programming approach is proposed to select optimally among a given set of products and allocate integer shelf-space units to the selected products in supermarkets. The approach is designed to consider general objective-function specifications that account for space elasticity, costs of sales, and potential demand-related marketing variables. The optimization is subject to constraints due to product supply availability, 'block' product allocation and operational requirements. A primary focus is on the development of a tractable model approach that can effectively be implemented on a microcomputer. A discussion of applications and computational experience on a microcomputer is provided to support the practical applicability of the optimization approach.
[The effect of foreign-substance-metabolizing enzymes on skin diseases]. (1992)

Multiple drug-metabolizing enzymes are located in the skin of animals and humans: cytochrome P-450, epoxide hydrases, transferases and reductases. The distribution of cytochrome P-450 in the skin is not homogeneous; rather, it is more active in the basal epidermis, keratinocytes of the hair follicle, and sebaceous cells. The activity of drug-metabolizing enzyme can be induced, but it can also be inhibited by multiple endogenous and exogenous compounds. These enzymes detoxify many xenobiotics, but if the balance is disturbed there is the risk that xenobiotics will be activated to highly toxic compounds, which are even involved in the pathogenesis of skin cancer. Recent results indicate that cytochrome P-450 isoenzymes are also involved in the pathogenesis of psoriasis and drug-induced skin diseases.
Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model (1984)

A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial blood pressure to 50 mm Hg, the latter being achieved by bleeding, or by bleeding supplemented with administration of trimetaphan or phentolamine. By the use of intubation, muscle paralysis with suxamethonium chloride, and insertion of tail arterial and venous catheters, it was possible to induce reversible ischemia for long-term recovery studies. Autoradiographic measurements of local CBF showed that the procedure reduced CBF in neocortical areas, hippocampus, and caudoputamen to near-zero values, flow rates in a number of subcortical areas being variable. Administration of trimethaphane or phentolamine did not affect ischemic and postischemic flow rates, nor did they alter recovery of EEG and sensory-evoked responses, but trimetaphan blunted the changes in plasma concentrations of adrenaline and noradrenaline. Recovery experiments showed that 10 min of ischemia gave rise to clear signs of permanent brain damage, with a small number of animals developing postischemic seizures that led to the death of the animals in status epilepticus. After 15 min of ischemia, such alterations were more pronounced, and the majority of animals died. It is concluded that the short revival times noted are explained by the fact that the model induces near-complete ischemia, and that recovery following forebrain ischemia is critically dependent on residual flow rates during the period of ischemia.
Learning-Based Vertebra Detection and Iterative Normalized-Cut Segmentation for Spinal MRI (2009)

Automatic extraction of vertebra regions from a spinal magnetic resonance (MR) image is normally required as the first step to an intelligent spinal MR image diagnosis system. In this work, we develop a fully automatic vertebra detection and segmentation system, which consists of three stages; namely, AdaBoost-based vertebra detection, detection refinement via robust curve fitting, and vertebra segmentation by an iterative normalized cut algorithm. In order to produce an efficient and effective vertebra detector, a statistical learning approach based on an improved AdaBoost algorithm is proposed. A robust estimation procedure is applied on the detected vertebra locations to fit a spine curve, thus refining the above vertebra detection results. This refinement process involves removing the false detections and recovering the miss-detected vertebrae. Finally, an iterative normalized-cut segmentation algorithm is proposed to segment the precise vertebra regions from the detected vertebra locations. In our implementation, the proposed AdaBoost-based detector is trained from 22 spinal MR volume images. The experimental results show that the proposed vertebra detection and segmentation system can achieve nearly 98% vertebra detection rate and 96% segmentation accuracy on a variety of testing spinal MR images. Our experiments also show the vertebra detection and segmentation accuracies by using the proposed algorithm are superior to those of the previous representative methods. The proposed vertebra detection and segmentation system is proved to be robust and accurate so that it can be used for advanced research and application on spinal MR images.
Automatic test program generation for pipelined processors (1994)

Simulation-based verification has both advantages and disadvantages compared with formal verification. Our demand is to find a practical way to verify actual microprocessors. This paper presents an efficient test program generation method for simulation-based verification using techniques developed for formal verification. Our test program generator enumerates all reachable states of a processor pipeline and generates instruction sequences for every reachable test care. The program covers complicated test cases that are difficult to cover with random instructions and impossible to cover with conventional test program generation methods. Our test program generator also works for larger microprocessor designs than formal verifiers have done.