gebhart/patrepeval huggingface dataset:
Silver-Impregnated Vacuum-Assisted Closure in the Treatment of Recalcitrant Venous Stasis Ulcers (2007)

Vacuum-assisted closure (VAC) has made a significant contribution to the treatment of acute and chronic wounds. Microdeformational forces from the VAC device accelerate granulation tissue formation when compared with moist saline dressing changes. We present 2 patients with multiple comorbid conditions and complex venous stasis ulcers that had persistent purulent drainage after conventional treatment modalities. Only after utilizing silver-impregnated VAC therapy (GranuFoam Silver), combining the antimicrobial benefits of silver with the advantages of VAC technology, were the wound beds adequately prepared for substantial split-thickness skin grafts. Based on these cases, the silver-impregnated VAC device may be a useful adjunct in wound bed preparation when standard therapies have failed to clear infected wounds. This may lead to improved healing rates and overall decreased wound burden in these complex patients.
FITNESS-failure immunization technology for network services survivability (2003)

For optical fiber systems carrying multiple Gb/s, the failure of a key fiber-optic system can result in huge loss of bandwidth. Failure immunization technology for network service survivability (FITNESS) is proposed method to restore fiber networks in a distributed fashion using broadband digital cross-connect systems (B-DCS) in a synchronous optical network (SONET). With intelligent B-DCS cross-connecting at the synchronous transport signal level 1 (STS-1), level, FITNESS unites this distributed intelligence into a single coherent parallel-processing entity to restore the network in under two seconds. Some performance results are obtained through software emulation using a real LATA model are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. (1996)

Hippocampal neuron loss is widely viewed as a hallmark of normal aging. Moreover, neuronal degeneration is thought to contribute directly to age-related deficits in learning and memory supported by the hippocampus. By taking advantage of improved methods for quantifying neuron number, the present study reports evidence challenging these long-standing concepts. The status of hippocampal-dependent spatial learning was evaluated in young and aged Long-Evans rats using the Morris water maze, and the total number of neurons in the principal cell layers of the dentate gyrus and hippocampus was quantified according to the optical fractionator technique. For each of the hippocampal fields, neuron number was preserved in the aged subjects as a group and in aged individuals with documented learning and memory deficits indicative of hippocampal dysfunction. The findings demonstrate that hippocampal neuronal degeneration is not an inevitable consequence of normal aging and that a loss of principal neurons in the hippocampus fails to account for age-related learning and memory impairment. The observed preservation of neuron number represents an essential foundation for identifying the neurobiological effects of hippocampal aging that account for cognitive decline.
Microbial Asymmetric Catalysis—Enantioselective Reduction of Ketones [New Synthetic Methods (45)] (1984)

Abstract Microbial asymmetric reduction of ketones is a method widely used for the preparation of chiral alcohols. The present progress report deals with the basic concepts that govern enantioselectivity of enzymes and intact cells. Strategies to control the stereochemical course of microbial reductions of carbonyl compounds and the relationship of substrate structure to enantioselectivity are considered.
Increased plasma levels of nerve growth factor in vernal keratoconjunctivitis and relationship to conjunctival mast cells. (1995)

These data represent the first reported evidence of increased NGF plasma levels in an allergic human disease and suggest a possible relationship between this neurotrophic polypeptide and inflammatory cells in vernal keratoconjunctivitis.
Three-dimensional solubility parameters and their use in characterising the permeation of drugs through the skin. (1996)

The physico-chemical properties of drug substances are major determinants of their transdermal absorption. In the present study the concept of the three-dimensional solubility parameters of Hansen was applied in conjunction with the Bagley projection to describe the permeation of drugs and model substances through the skin. Drug permeation data from the literature were compared with the calculated solubility parameters of the drugs. It was demonstrated that the permeation of drugs can be estimated by their position in the Bagley diagram. There is a linear correlation between the logarithm of the skin permeation of drugs and the exchange cohesive energy for the steroids testosterone, progesterone, hydrocortisone acetate, corticosterone, cortisone, and dexamethasone. A linear correlation can be confirmed for the permeation of glyceryl trinitrate, digitoxin, oestradiol, scopolamine, atropine, diethylcarbamazine, fentanyl, and chlorpheniramine. In the case of morphine, codeine, sufentanil, meperidine and hydromorphone there is a linear relationship, too.
New Bis(2-aminoimidazoline) and Bisguanidine DNA Minor Groove Binders with Potent in Vivo Antitrypanosomal and Antiplasmodial Activity (2008)

A series of 75 guanidine and 2-aminoimidazoline analogue molecules were assayed in vitro against Trypanosoma brucei rhodesiense STIB900 and Plasmodium falciparum K1. The dicationic diphenyl compounds exhibited the best activities with IC 50 values against T. b. rhodesiense and P. falciparum in the nanomolar range. Five compounds (7b, 9a, 9b, 10b, and 14b) cured 100% of treated mice upon ip administration at 20 mg/kg in the difficult to cure T. b. rhodesiense STIB900 mouse model. Overall, the compounds that bear the 2-aminoimidazoline cations benefit from better safety profiles than the guanidine counterparts. The observation of a correlation between DNA binding affinity at AT sites and trypanocidal activity for three series of compounds supported the view of a mechanism of antitrypanosomal action due in part to the formation of a DNA complex. No correlation between antiplasmodial activity and in vitro inhibition of ferriprotoporphyrin IX biomineralisation was observed, suggesting that additional mechanism of action is likely to be involved.
Ethylene oxide sterilization of medical devices--with special reference to the sporicidal activity and residual concentration of ethylene oxide and its secondary products. (1982)

For the sterilization of disposable medical devices, ethylene oxide gas is used in most cases. When this sterilization method is used, ethylene oxide (EO) and its secondary products, i.e., ethylene chlorohydrin (ECH) and ethylene glycol (EG), remain in the medical devices after sterilization. If their concentration is high, these residues are liable to cause hemolytic activity and dermal or mucous membrane irritability in the human body. For this reason, in 1978 the FDA announced a proposal to regulate the residual limits of EO, ECH and EG. Our studies were done to examine the conditions of EO sterilization from the viewpoints of the sterilization effect and the residual chemical substances and to find the optimum conditions for sterilization. Further, the aerator was fabricated for the exclusive purpose of reducing, within a brief period, the concentration of EO and other substances remaining in the medical devices after sterilization and we examined the condition of aeration by using this aerator. As the result, it was found that a satisfactory sterilization effect could be obtained under the sterilization conditions of an EO gas concentration of 500 mg/liter, a sterilizing temperature of 55 to 60 degrees C and a sterilizing time of two hours, and under these conditions the concentration of the residual substances such as the EO could be made comparatively lower. It was also clarified that the minimum required aeration conditions by using the exclusive-use aerator were a temperature of 55 to 60 degrees C and an aeration time of 24 hours and over.
Hedonic Hot Spots in the Brain (2006)

Hedonic "liking" for sensory pleasures is an important aspect of reward, and excessive 'liking' of particular rewards might contribute to excessive consumption and to disorders such as obesity. The present review aims to summarize recent advances in the identification of brain substrates for food 'liking' with a focus on opioid hot spots in the nucleus accumbens and ventral pallidum. Drug microinjection studies have shown that opioids in both areas amplify the 'liking' of sweet taste rewards. Modern neuroscience tools such as Fos plume mapping have further identified hedonic hot spots within the accumbens and pallidum, where opioids are especially tuned to magnify 'liking' of food rewards. Hedonic hot spots in different brain structures may interact with each other within the larger functional circuitry that interconnects them. Better understanding of how brain hedonic hot spots increase the positive affective impact of natural sensory pleasures will help characterize the neural mechanisms potentially involved in 'liking' for many rewards.
The TNF ligand superfamily and its relevance for human diseases. (1995)

The tumor necrosis factor (TNF) receptor superfamily comprises 10 different members of type I integral membrane glycoproteins with characteristic limited sequence homology for the extracellular cysteine-rich repeats. A parallel existing TNF ligand superfamily has been discovered by cloning of ligands for all of the TNF receptor superfamily members. These molecules are type II membrane glycoproteins, with the exception of LT-alpha, which is the only secreted protein of the family. TNF and CD95L also exist in biologically active shed soluble form. The TNF ligand superfamily presently contains nine different proteins. In addition, the NGFR p75 binds to a second family of proteins. These NGF-like dimeric soluble molecules are basic neurotrophic factors, and the five members are not related to the TNF superfamily ligands. The TNF-like ligands share some common biological activities, but other activities appear to be shared only by some ligands or are unique. The diverse biological effects mediated through the interaction of the members of the TNF receptor and ligand superfamilies have provided information on the regulation of cellular activation, including the involvement of T-cell-dependent immune responses as well as associations with human diseases.
ITU-T Recommendation G.729 Annex B: a silence compression scheme for use with G.729 optimized for V.70 digital simultaneous voice and data applications (1997)

This article describes Annex B to ITU-T Recommendation G.729. Annex B defines a low-bit-rate silence compression scheme designed and optimized to work in conjunction with both the full version of G.729 and its low-complexity Annex A. To achieve good quality low-bit-rate silence compression, a robust frame-based voice activity detector module is essential to detect inactive voice frames, also called silence or background noise frames. For these detected inactive voice frames, a discontinuous transmission module measures the changes over time of the inactive voice signal characteristics and decides whether a new silence information descriptor frame should be sent to maintain the reproduction quality of the background noise at the receiving end. If such a frame is needed, the spectrum and energy parameters describing the perceptual characteristics of the background noise are efficiently coded and transmitted using 15 b/frame. At the receiving end, the comfort noise generation module regenerates the output background noise using transmitted updates or previously available parameters. The synthesized background noise is obtained by linear predictive filtering of a locally generated pseudo-white excitation signal of a controlled level. This method of coding the background noise enables the achievement of bit-rate savings for coded speech at average rates as low as 4 kb/s during normal speech conversation while maintaining reproduction quality.
Precoding and Power Allocation for Cooperative MIMO Systems (2006)

The fundamental capacity limit in cooperative MIMO channels with one source-destination pair and one relay is investigated. With the channel state information (CSI) at the source and destination, the optimal precode and power allocation to maximize the capacity with the total transmit power constraints are addressed under different cooperative modes including amplify-and-forward (AF), decode-and-forward (DF) and superposition coding (SC). We study the impact of the number of receive antennas, SNR and the distance between relay and destination on the achievable capacity. The Simulation results show that AF, DF and SC have higher spectral efficiency than direct transmission (DT) for the low SNR regime case and small distance between relay and destination case. In general, SC outperforms DF which outperforms AF
Identification, Synthesis, and Pharmacological Evaluation of Tetrahydroindazole Based Ligands as Novel Antituberculosis Agents (2009)

The resurgence of tuberculosis (TB), the incidence of drug-resistant strains of Mycobacterium tuberculosis (MTB), and the coinfection between TB and HIV have led to serious infections, high mortality, and a global health threat, resulting in the urgent search for new classes of antimycobacterial agents. Herein, we report the identification of a novel class of tetrahydroindazole based compounds as potent and unique inhibitors of MTB. Compounds 6a, 6m, and 6q exhibited activity in the low micromolar range against replicating Mycobacterium tuberculosis (R-TB) phenotype, with minimum inhibitory concentrations (MICs) of 1.7, 1.9, and 1.9 muM, respectively, while showing no toxicity to Vero Ccells. Moreover, studies aimed to assess the in vitro metabolic stability of 6a and 6m in mouse liver microsomes and in vivo pharmacokinetic profiles in plasma levels gave satisfactory results. This research suggests that tetrahydroindazole based anti-TB compounds can serve as a promising lead scaffold in developing new drugs to combat tuberculosis infections.
Newly Developed Direct-Connect High-Enthalpy Supersonic Combustion Research Facility (2001)

Anew continuous-e ow,direct-connect,high-enthalpy, supersonic combustion researchfacility isdescribed. This test facility provides combustor inlet e ow conditions corresponding to e ight Mach numbers between 3.5 and 7, at dynamic pressures up to 95.8 kPa. Most of the major components of the new facility are water cooled (including the vitiated heater, the instrumentation and transition sections, and the facility nozzle and isolators ); the current exception is the variable-geometry heat-sink combustor. A variety of conventional and advanced instrumentation, including a steam calorimeter and a thrust stand, exists for accurate documentation of combustor inlet and exit conditions and performance parameters. In a recent calibration effort, pitot pressure surveys, total temperature surveys, and wall static pressure distributions were obtained for a wide range of inlet conditions using Mach 1.8 and 2.2 facility nozzles. In addition, three-dimensional numerical simulations of each test case were completed. Results from thecomputations compare favorably with experimental results for all cases and yield estimates of the integral boundary-layer properties at the isolator exit.
Analytical Procedure for the Determination of the Marijuana Metabolite 11-nor- 9-Tetrahydrocannabinol-9-carboxylic Acid in Oral Fluid Specimens (2006)

The determination of the marijuana metabolite 11-nor-Delta(9)-tetrahydrocannabinol-9-carboxylic acid (THCA) in oral fluid specimens is described for the first time using a Quantisal oral fluid collection device and gas chromatography with single-quadrupole mass spectrometric detection. Oral fluid specimens were confirmed for the presence of THCA using two-dimensional gas chromatography-mass spectrometry in order to achieve the low concentration levels previously reported to be present in oral fluid. The extraction efficiency for THCA from the oral fluid collection pad was determined to be 80% at a concentration of 10 pg/mL with a coefficient of variation of 8.23%. The intraday precision of the assay ranged from 3.4% to 7.9% over four concentrations; the interday precision ranged from 8.3% to 18.5%. The limit of quantitation was 2 pg/mL. The method was applied to oral fluid specimens collected from a frequent user of marijuana. Samples were collected almost immediately after the subject smoked and then at intervals of 15 and 45 min and 1, 2, and 8 h after smoking. THCA was present in all the specimens, even the initial specimen taken almost immediately after smoking. The presence of THCA minimizes the argument for passive exposure to marijuana in drug-testing cases.
A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer. (1997)

Gene transfer of BRCA1sv (a normal splice variant of BRCA1) into ovarian cancer cells produces growth inhibition in vitro and tumor suppression in nude mouse xenografts. As an initial step toward gene replacement therapy for ovarian cancer, we conducted a Phase I trial to assess the pharmacokinetics and toxicity of i.p. BRCA1sv retroviral vector therapy. Following placement of an indwelling Port-a-Cath in patients, a dose escalation study was performed of four daily i.p. infusions spanning doses from 3 to 300 ml (i.e., 10(10) viral particles) at half-log intervals (23 cycles in 12 patients). Gene transfer and expression were documented by PCR, Southern blot, reverse transcription-PCR, and nuclease protection assays. Pharmacokinetics were assessed by PCR and Southern blots detecting vector DNA, and toxicity was evaluated by clinical exam and fluid analysis. Three of 12 patients developed an acute sterile peritonitis, which spontaneously resolved within 48 h. Plasma and peritoneal antibodies to the retroviral envelope protein were detected only in patients treated with the highest dose levels but not in others, despite repeat dosing for an interval of up to 4 months. Eight patients showed stable disease for 4-16 weeks, and three patients showed tumor reduction with diminished miliary tumor implants at reoperation (two patients) and radiographic shrinkage of measurable disease (one patient). The vector-related complication of peritonitis was observed in three patients but resolved quickly as in preclinical mouse studies. Ovarian cancer may provide an important model for retroviral gene therapy studies due to vector stability, minimal antibody response, and access to tumor by i.p. therapy.
AddressSanitizer: a fast address sanity checker (2012)

Memory access bugs, including buffer overflows and uses of freed heap memory, remain a serious problem for programming languages like C and C++. Many memory error detectors exist, but most of them are either slow or detect a limited set of bugs, or both.

This paper presents AddressSanitizer, a new memory error detector. Our tool finds out-of-bounds accesses to heap, stack, and global objects, as well as use-after-free bugs. It employs a specialized memory allocator and code instrumentation that is simple enough to be implemented in any compiler, binary translation system, or even in hardware.

AddressSanitizer achieves efficiency without sacrificing comprehensiveness. Its average slowdown is just 73% yet it accurately detects bugs at the point of occurrence. It has found over 300 previously unknown bugs in the Chromium browser and many bugs in other software.
Transcription factor binding and spacing constraints in the human β-actin proximal promoter (1991)

The human beta-actin promoter, including its 5' flanking region and 5' untranslated region, is ubiquitously active in mammalian cells in culture. In this report we investigated the transcriptional activity of, and the protein-DNA interactions that occur within, the proximal region of the human beta-actin promoter. Efficient beta-actin promoter activity in transfected human HeLa cells requires only 114bp of 5' flanking sequences. Two of the cis-actin regulatory elements within this region of the beta-actin promoter, the CCAAT box and proximal CCArGG box, are specific in vitro binding sites for the transcription factors, nuclear factor Y (NF-Y) and serum response factor (p67SRF), respectively. These two elements are required together to stimulate in vivo transcription from the homologous as well as a heterologous promoter. Finally, a particular spatial alignment between the CCAAT box and proximal CCArGG box is required for trans-activation in vivo. The above provides strong evidence for a functional interaction between NF-Y and p67SRF when bound to their respective binding sites in the beta-actin promoter.
Experimental analysis of multidimensional radio channels (2002)

In this thesis new systems for radio channel measurements including space and polarization dimensions are developed for studying the radio propagation in wideband mobile communication systems. Multidimensional channel characterization is required for building channel models for new systems capable of exploiting the spatial nature of the channel. It also gives insight into the dominant propagation mechanisms in complex radio environments, where their prediction is difficult, such as urban and indoor environments.\n\nThe measurement systems are based on the HUT/IDC wideband radio channel sounder, which was extended to enable real-time multiple output channel measurements at practical mobile speeds at frequencies up to 18 GHz. Two dual-polarized antenna arrays were constructed for 2 GHz, having suitable properties for characterizing the 3-D spatial radio channel at both ends of a mobile communication link. These implementations and their performance analysis are presented.\n\nThe usefulness of the developed measurement systems is demonstrated by performing channel measurements at 2 GHz and analyzing the experimental data. Spatial channels of both the mobile and base stations are analyzed, as well as the double-directional channel that fully characterizes the propagation between two antennas. It is shown through sample results that spatial domain channel measurements can be used to gain knowledge on the dominant propagation mechanisms or verify the current assumptions. Also new statistical information about scatterer distribution at the mobile station in urban environment is presented based on extensive real-time measurements. The developed techniques and collected experimental data form a good basis for further comparison with existing deterministic propagation models and development of new spatial channel models.