gebhart/patrepeval huggingface dataset:
Local therapy and treatment costs of chronic, venous leg ulcers with electrical stimulation (Dermapulse®): A prospective, placebo controlled, double blind trial (2008)

The purpose of our study was the evaluation of the therapeutic benefit and the economical profit of low-frequency pulsed current applied to therapy-resistant venous leg ulcers. We investigated 39 patients in a prospective, placebo-controlled, double blind study on the effect of low-frequency pulsed current (Dermapulse) on healing in chronic venous ulcers during a 4-month course of treatment. All patients had chronic venous ulcers. The following criteria were recorded: ulcer size, pain, capillary density, and transcutaneous oxygen partial pressure. In verum group 3, ulcers healed and ulcer area was reduced significantly. In placebo group two ulcers healed. Ulcer size was reduced significantly in each group (paired test), the difference of ulcer area reduction between the "verum" and the placebo group (unpaired test) was not significant. Capillary density in the ulcer increased in both groups. In verum group, electrical stimulation led to rapid and lasting reduction of pain (unpaired test, p=0.049). By means of the process calculation method for the subgroup of outpatients this treatment method was economically effective. Electrical stimulation seems to be a viable treatment option for therapy-resistant venous leg ulcers.
Analyses of Risk, Racial Disparity, and Outcomes Among US Patients With Cancer and COVID-19 Infection (2020)

In this case-control study, patients with cancer were at significantly increased risk for COVID-19 infection and worse outcomes, which was further exacerbated among African Americans. These findings highlight the need to protect and monitor patients with cancer as part of the strategy to control the pandemic.
Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: Implications for tumor angiogenesis (1996)

Studies aimed at elucidating the function of the protein synthesis factor eukaryotic initiation factor 4E (elF-4E) have demonstrated that overexpression of this protein results in marked cell phenotypic and proliferative changes, including neoplastic transformation of cells. These data suggest that elF-4E may somehow participate in the development and progression of tumors in vivo. In order to determine how elF-4E exerts its transforming effects, we examined vascular permeability factor (VPF) levels in cells transfected with an elF-4E vector. Cells overexpressing elF-4E showed an increase in intracellular, and an average 130-fold increase in secreted VPF protein levels (CHO 0.13+/-0.12 ng/ml; CHO-4E 20.5+/-12.5 ng/ml) over control cells. HUVEC growth induction revealed these VPF levels to be biologically active. Northern analysis revealed no difference in VPF transcript between the 2 cell lines. Polysome analysis showed that the VPF message in elF-4E-transfected cells was associated with the heavy polysomal regions, whereas the VPF message was associated with light polysomes in control cells. These data strongly suggest that enhanced VPF expression is achieved through translational regulation rather than transcriptional regulation in cells overexpressing elF-4E. This indicates that elF-4E-induced VPF expression may be an important factor in some forms of tumor angiogenesis and development.
Experimental and modeling studies of imaging with curvilinear electronic eye cameras (2010)

Model calculations and the experimental measurements of the imaging properties of planar, hemispherical, and elliptic parabolic electronic eye cameras are compared. Numerical methods for comprehensive full field calculations of image formation are enabled by use computationally efficient modes. Quantitative agreement between these calculations and experimentally measured images of test patterns reveals advantages of curvilinear camera systems, and provides guidelines for future designs.
In situ infrared spectroscopic studies of redox active self-assembled monolayers on gold electrode surfaces (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ infrared spectroscopic studies of redox active self-assembled monolayers on gold electrode surfacesI. T. Bae, H. Huang, E. B. Yeager, and D. A. SchersonCite this: Langmuir 1991, 7, 8, 1558–1562Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://doi.org/10.1021/la00056a002Request reuse permissionsArticle Views98Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (583 KB) Get e-Alertsclose Get e-Alerts
Medium-dependent regulation of proteinase gene expression in Lactococcus lactis: control of transcription initiation by specific dipeptides (1995)

Transcriptional gene fusions with the Escherichia coli beta-glucuronidase gene (gusA) were used to study the medium- and growth-dependent expression of the divergently transcribed genes involved in proteinase production (prtP and prtM) of Lactococcus lactis SK11. The results show that both the prtP and prtM genes are controlled at the transcriptional level by the peptide content of the medium and, to a lesser extent, by the growth rate. A more than 10-fold regulation in beta-glucuronidase activity was observed for both prtP and prtM promoters in batch and continuous cultures. The level of expression of the prtP and prtM promoters was high in whey permeate medium with relatively low concentrations of peptides, whereas at increased concentrations the expression of the promoters was repressed. The lowest level of expression was observed in peptide- and amino acid-rich laboratory media, such as glucose-M17 and MRS. The addition of specific dipeptides, such as leucylproline and prolylleucine, to the growth medium negatively affected the expression of the prtP-gusA fusions. The repression by dipeptides was not observed in mutants defective in the uptake of di-tripeptides, indicating that the internal concentration of dipeptides or derivatives is important in the regulation of proteinase production.
Development of recombinant human polyclonal antibodies for the treatment of complex human diseases (2006)

Antibodies are a central factor in the immunity against invading pathogens, such as bacteria and viruses, as well as against malignantly transformed cells. Natural antibody responses are polyclonal, comprising antibodies against several epitopes, thus increasing the probability of eliminating the invading pathogen or malignant cell. The pharmacological advantage of polyclonality is exploited in the plasma-derived immunoglobulin products used at present to treat a number of infectious diseases. However, the use of plasma-derived products is limited by their cost, inconvenience of use and potential for transferring diseases from the donor to the patient. Symphogen has developed technologies to capture the advantages of antibody polyclonality while eliminating the potential safety risk associated with the sourcing of human material. Hence, the Symplex technology has been developed to identify diverse repertoires of target-specific, fully human antibodies. For the controlled manufacture of recombinant polyclonal antibody drugs, Symphogen has developed the Sympress technology. Combined, these two technologies allow the identification and industrial manufacturing of recombinant human polyclonal antibodies for medical use in humans. The authors believe that this new class of therapeutic antibodies will be advantageous in the treatment of complex human diseases, such as cancer and infection, as it allows the combination of several treatment modalities in one drug.
Customizing Sentiment Classifiers to New Domains: a Case Study (2005)

Sentiment classification is a very domain specific problem; classifiers trained in one domain do not perform well in others. Unfortunately, many domains are lacking in large amounts of labeled data for fully-supervised learning approaches. At the same time, sentiment classifiers need to be customizable to new domains in order to be useful in practice. We attempt to address these difficulties and constraints in this paper, where we survey four different approaches to customizing a sentiment classification system to a new target domain in the absence of large amounts of labeled data. We base our experiments on data from four different domains. After establishing that naive cross-domain classification results in poor classification accuracy, we compare results obtained by using each of the four approaches and discuss their advantages, disadvantages and performance.
[Adjuvant chemo-endocrine chemotherapy with gastrin antagonist after resection of liver metastasis in colorectal cancer]. (1994)

This study was designed to determine whether or not chemo-endocrine therapy after the resection of liver metastasis from colorectal cancer would prevent re-recurrence in the liver. Postoperatively, seven patients received proglumide gastrin antagonist (1,200 mg/day) +5'-DFUR (800 mg/day) orally for 2 years. MMC 6-10 mg and ADR 20 mg were infused every two weeks alternately for 1 year via catheter in the common hepatic artery. After median follow-up of 39 months, re-recurrence rate in the remnant liver after hepatic resection was 14% (1/7) for patients with chemo-endocrine therapy and 52% (24/46) for the controls. These results suggest the possibility that chemo-endocrine therapy is effective to prevent re-recurrence of liver metastasis in patients with colorectal cancer.
RANDOMIZED DOUBLE BLIND CLINICAL TRIAL OF INTRAMUSCULAR DEXMEDETOMIDINE V/S MIDAZOLAM AS PREMEDICATION IN PAEDIATRIC SURGICAL PATIENTS (2016)

A genuine attempt was made to find ideal drug for premedication in paediatric surgical patients. Dexmedetomidine a newer, highly selective alpha-2 agonist was compared to midazolam via intramuscular route. Setting:
Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor. (1996)

These results reveal a new site of synthesis (ciliary epithelium) and accumulation (aqueous humor) of PEDF, and they emphasize its potential importance as a trophic factor in the neuro-differentiated functions of the human ciliary epithelium.
Integrated Innate Mechanisms Involved in Airway Allergic Inflammation to the Serine Protease Subtilisin (2015)

Proteases are recognized environmental allergens, but little is known about the mechanisms responsible for sensing enzyme activity and initiating the development of allergic inflammation. Because usage of the serine protease subtilisin in the detergent industry resulted in an outbreak of occupational asthma in workers, we sought to develop an experimental model of allergic lung inflammation to subtilisin and to determine the immunological mechanisms involved in type 2 responses. By using a mouse model of allergic airway disease, we have defined in this study that s.c. or intranasal sensitization followed by airway challenge to subtilisin induces prototypic allergic lung inflammation, characterized by airway eosinophilia, type 2 cytokine release, mucus production, high levels of serum IgE, and airway reactivity. These allergic responses were dependent on subtilisin protease activity, protease-activated receptor-2, IL-33R ST2, and MyD88 signaling. Also, subtilisin stimulated the expression of the proallergic cytokines IL-1α, IL-33, thymic stromal lymphopoietin, and the growth factor amphiregulin in a human bronchial epithelial cell line. Notably, acute administration of subtilisin into the airways increased lung IL-5-producing type 2 innate lymphoid cells, which required protease-activated receptor-2 expression. Finally, subtilisin activity acted as a Th2 adjuvant to an unrelated airborne Ag-promoting allergic inflammation to inhaled OVA. Therefore, we established a murine model of occupational asthma to a serine protease and characterized the main molecular pathways involved in allergic sensitization to subtilisin that potentially contribute to initiate allergic airway disease.
1‐(2′‐Deoxy‐β‐D‐xylofuranosyl)thymine Building Blocks for Solid‐Phase Synthesis and Properties of Oligo(2′‐Deoxyxylonucleotides) (1991)

Abstract 1‐(2′‐Deoxy‐β‐ D ‐ threo ‐pentofuranosyl)thymine (= 1‐(2′‐deoxy‐β‐ D ‐xylofuranosyl)thymine; xT d ; 2 ) was converted into its phosphonate 3b as well as its 2‐cyanoethyl phosphoramidite 3c . Both compounds were used for solid‐phase synthesis of d[(xT) 12 ‐T] ( 5 ), representing the first DNA fragment build up from 3′–5′‐linked 2′‐deoxy‐‐β‐ D ‐xylonucleosides. Moreover, xT d was introduced into the innermost part of the self‐complementary dodecamer d(G‐T‐A‐G‐A‐A‐xT‐xT‐C‐T‐A‐C) 2 (9). The CD spectrum of d[(xT) 12 –T] ( 5 ) exhibits reversed Cotton effects compared to d(T 12 ) ( 6 ; see Fig. 1 ), implying a left‐handed single strand. With d(A 12 ) ( 7 ) it could be hybridized to form a propably Left‐handed double strand d(A 12 ) · d[(xT) 12 –T] ( 7 · 5 ) which was confirmed by melting experiments in combination with temperature‐dependent CD spectroscopy. While 5 was hydrolyzed by snake‐venom phosphodiesterase, it was resistant towards calf‐spleen phosphodiesterase. The modified, self‐complementary duplex 9 was hydrolyzed completely by snake‐venom phosphodiesterase, at a twelvefold slower rate compared to unmodified 8 ; calf‐spleen phosphodiesterase hydrolyzed 9 only partially.
Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet (2020)

In a rat model of metabolic syndrome, chronic LIRA treatment improved the capacity for NO-mediated dilation throughout the coronary macro and microcirculations and partially normalized myocardial remodeling independent of changes in body mass or blood glucose.
An Improved Element for Use in Array Antennas (1975)

A new element is described which is useful in array antennas. This element has a circular symmetric radiation pattern, controllable beamwidth, and exhibits extremely low mutual coupling between elements in the array. A modification of this antenna element results in a single antenna having equal E- and H-plane patterns, no side lobes and extremely low back radiation.
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication (2006)

Antibodies against nuclear self-antigens are characteristic of systemic autoimmunity, although mechanisms promoting their generation and selection are unclear. Here, we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrinsically biased toward nucleolar antigens because of increased expression of TLR7, a single-stranded RNA-binding innate immune receptor. The TLR7 gene is duplicated in Yaa mice because of a 4-Megabase expansion of the pseudoautosomal region. These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation.
Experimental distinction between phase shifts and time delays: Implications for femtosecond spectroscopy and coherent control of chemical reactions (1999)

Two different definitions of phase shifts and time delays are contrasted and shown to match different experimental methods of generating delayed pulses. Phase shifts and time delays are usually defined in terms of a carrier wave in magnetic resonance, but definitions based on the envelope of a single pulse are useful in optics. It is demonstrated experimentally that a frequency domain measurement using spectral interferometry can simultaneously measure phase shifts with an accuracy of 0.1 rad (2σ) and time delays with a precision of 40 attoseconds (2σ) for 25 femtosecond optical pulses. Envelope time delays are generated by pathlength differences in an interferometer. Constant spectral phase shifts are demonstrated by diffracting pulses from a variable phase volume diffraction grating. Experimental requirements for phase-resolved spectroscopy are outlined. The theory of phase-locked pulse pair techniques is reexamined, and it is concluded that linear experiments with phase-locked pulse pairs are completely equivalent to Fourier transform absorption spectroscopy and do not measure the refractive index or real part of the susceptibility. It is shown that Fourier sine and cosine transformations of truncated time domain signals which do not match the symmetry of the complete signal can produce a false dispersive susceptibility because they are equivalent to Kramers–Kronig inversion of finite bandwidth absorption data. A procedure for shifting π/2 phase-locked transients by a quarter cycle of delay to generate a transient with a π/2 spectral phase shift is given. Equations used to calculate femtosecond nonlinear optical signals have assumed carrier wave delays. Modifications to these equations are required when envelope delays are generated by interferometer pathlength differences and modified equations are given. The modified equations yield significantly different results for phase-resolved or interferometric experiments. In particular, the modified equations are needed to calculate indirectly (interferometrically) detected frequencies and the real and imaginary parts of two-dimensional Fourier transform spectra. The role of the refractive index and real part of the frequency domain susceptibility in nonlinear experiments with phase-locked pulse pairs is explored. It is concluded that experiments such as the heterodyne detected stimulated photon echo are insensitive to nonlinear refractive index changes under some circumstances. Finally, modifications of some equations used in the theory of coherent control are needed to match theory with experimental practice.
Percutaneous Penetration of 14C Hydrocortisone in Man (1966)

Single doses of radiolabeled<sup>14</sup>C hydrocortisone and testosterone were applied to the human forearm; rates and quantities of<sup>14</sup>C penetration were determined by assay of<sup>14</sup>C urine for five days. Dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) increased penetration of both steroids threefold to fourfold. Mineral oil was without obvious effect; propylene glycol (PG) and dimethyl acetamide (DMAC) decreased the penetration of hydrocortisone and moderately increased that of testosterone.
Chemotaxonomy of mints of genus Mentha by applying Raman spectroscopy (2002)

The characterization of mints is often problematic because Mentha is a taxonomically complex genus. In order to provide a fast and easy characterization method, we use a combination of micro-Raman spectroscopy and hierarchical cluster analysis. A classification trial of different mint taxa is possible for one collection time. For spectra measured at different points during the growing season, a more sophisticated pretreatment of the data is necessary to receive good discrimination between the species, as well as between the subspecies and varieties of the mints.
Enantioselective Synthesis of the PPARα Agonist (R)-K-13675 via (S)-2-Hydroxybutyrolactone (2008)

Corrected by: Enantioselective Synthesis of the PPARα Agonist (R)-K-13675 via (S)-2-HydroxybutyrolactoneSynthesis 2008; 2008(13): 2154-2154DOI: 10.1055/s-2008-1067138
Clone attack! Perception of crowd variety (2008)

When simulating large crowds, it is inevitable that the models and motions of many virtual characters will be cloned. However, the perceptual impact of this trade-off has never been studied. In this paper, we consider the ways in which an impression of variety can be created and the perceptual consequences of certain design choices. In a series of experiments designed to test people's perception of variety in crowds, we found that clones of appearance are far easier to detect than motion clones. Furthermore, we established that cloned models can be masked by color variation, random orientation, and motion. Conversely, the perception of cloned motions remains unaffected by the model on which they are displayed. Other factors that influence the ability to detect clones were examined, such as proximity, model type and characteristic motion. Our results provide novel insights and useful thresholds that will assist in creating more realistic, heterogeneous crowds.
The Dominating Role of N-Deacetylase/N-Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate (2011)

Heparan sulfate (HS) is a highly sulfated polysaccharide participated in essential physiological functions from regulating cell growth to blood coagulation. HS contains sulfated domains known as N-S domains and low sulfate domains known as N-Ac domains. The distribution of the domain structures is likely governed by the action of glucosaminyl N-deacetylase/N-sulfotransferase (NDST). Here, we sought to determine the substrate specificity of NDST using model substrates and recombinant NDST protein. We discovered that NDST-1 carries out the modification in a highly ordered fashion. The enzyme sulfates the substrate from the nonreducing end toward the reducing end consecutively, leading to the product with a cluster of N-sulfo glucosamine residues. Furthermore, a preexisting N-sulfo glucosamine residue prevents the action of NDST-1 at the residues immediately located at the nonreducing end, allowing the formation of an N-Ac domain. Our results provide the long sought evidence for understanding the formation of sulfated versus nonsulfated domains in the HS isolated from cells and tissues. The study demonstrates the regulating role of NDST-1 in mapping the sulfation patterns of HS.
A STUDY ON ABUNDANCE INDICATOR FOR LATE TYPE DWARFS (1983)

From UBVRI photometry and space motion data of 232 late type dwarf stars, it is found that for the stars of (R-I)(U-B) and (B-V) color excesses are correlated with their orbital eccentricities. Therefore, (U-B) and (B-V) color excesses can be used as possible photometric abundance indicators for the stars of (R-I)0.5, the correlation between color excess and orbital eccentricity is not clear. However, it is interesting to note that the high orbital eccentricity stars show some blue deficiencies and these blue deficiencies seem to be correlated with orbital eccentricity.
Pathophysiological Consequences of HIF Activation (2009)

Tissue fibrosis is associated with structural and functional changes that limit blood flow and oxygen availability. In the kidney, tubulointerstitial fibrosis, which leads to progressive destruction of renal tissue and irreversible loss of kidney function, is associated with reduced tissue oxygen levels and activation of hypoxia-inducible factor (HIF) signaling. Although cytoprotective in acute injury models, HIF-1 was found to promote fibrosis in an experimental model of chronic renal injury following unilateral ureteral obstruction. Pharmacological inhibition of lysyl oxidases phenocopied the effects of genetic HIF-1 ablation on cell motility in vitro and on fibrogenesis in vivo, suggesting that lysyl oxidases are important mediators of profibrotic HIF signaling. These findings support the notion that HIF-mediated cellular responses differ under conditions of acute and chronic oxygen deprivation. Under certain conditions, these responses may lead to further tissue destruction by promoting fibrogenesis.