gebhart/patrepeval huggingface dataset:
A distributed object-oriented database system supporting shared and private databases (1991)

ORION-2 is a commercially available, federated, object-oriented database management system designed and implemented at MCC. One major architectural innovation in ORION-2 is the coexistence of a shared databese and a number of private databases. The shared database is accessible to all authorized users of the system, while each private database is accessible to only the user who owns it. A distributed database system with a shared database and private databases for individual users is a natural architecture for data-intensive application environments on a network of workstations, notably computer-aided design and engineering systems. This paper discusses the benefits and limitations of such a system and explores the impact of such an architecture on the semantics and implementation of some of the key functions of a database system, notably queries, database schema, and versions. Although the issues are discussed in the context of an object-oriented data model, the results (at least significant portions thereof) are applicable to database systems supporting other data models.
Sex Pili Mutants Isolated by Macarbomycin Treatment (1973)

Macarbomycin (MM) preferentially kills Escherichia coli carrying episomes derepressed for sex pili formation (drd episomes). Using MM, we have isolated various types of mutants from both F-lac.tet and R100-1 episomes and have classified them into two types by sex pili formation. Among 26 mutants, 20 could not produce pili and had lost both the ability for conjugal transmission and sensitivity to male phages. From 12 of these 20 mutants, revertants capable of pili formation could be obtained. Most of these had simultaneously regained susceptibility to MM, indicating that the MM susceptibility of E. coli carrying drd episomes is due to pili formation. Three of the revertants could not confer MM susceptibility on their host and two of them could not produce normal pili, indicating that there are some types of pili insensitive to MM. The six MM-resistant mutants could produce pili, but the frequency of pili formation was slightly lower than that of their parent episomes. Mutants of this type exhibited various degrees of decrease in conjugal transferability or male phage sensitivity, and one mutant produced pili that were altered in shape. It is suggested that this latter mutant became MM-resistant as a result of changes in the chemical composition of its pili.
Kinetic Properties of Saquinavir-Resistant Mutants of Human Immunodeficiency Virus Type 1 Protease and Their Implications in Drug Resistance in Vivo (1997)

In order to study the basis of resistance of human immunodeficiency virus, type 1 (HIV-1), to HIV-1 protease inhibitor saquinavir, the catalytic and inhibition properties of the wild-type HIV-1 protease and three saquinavir resistant mutants, G48V, L90M, and G48V/L90M, were compared. The kinetic parameter kcat/Km was determined for these proteases using eight peptide substrates whose sequences were derived from the natural processing site sequences of HIV-1. The kcat/Km values were determined using conventional steady-state kinetics as well as initial velocities of mixed substrate cleavages under the condition where the substrate concentrations [S]o << Km. The independently determined kcat and Km values for some of the substrates confirmed the accuracy of the mixed-substrate method and also permitted the calculation in all cases of true rather than relative kcat/Km values. The Ki values were also determined. Using a previously described kinetic model [Tang, J., & Hartsuck, J. A. (1995) FEBS Lett. 367, 112-116], the relative processing activities of HIV-1 protease variants were estimated in the saquinavir concentration range of 0-10(-7) M. Although the protease activity of G48V, L90M, and G48V/L90M are only about 10, 7, and 3% of that of the wild-type HIV-1 protease in the absence of inhibitor, the resistance tendencies of the three mutants are clearly manifest by relatively less activity loss as inhibitor concentration becomes higher. Also, the ratios of the activities of the four protease species at certain saquinavir concentrations appear to correlate with the population ratios of the four protease species at different time points of clinical trials. This correlation suggests that the population ratio of the protease species is driven by in vivo saquinavir concentration, which appears to be in the range 10(-10)-10(-9) M during the clinical trials.
Design of GaAs Solar Cells Operating Close to the Shockley–Queisser Limit (2013)

With recent advances in device design, single-junction GaAs solar cells are approaching their theoretical efficiency limits. Accurate numerical simulation may offer insights that can help close the remaining gap between the practical and theoretical limits. Significant care must be taken, however, to ensure that the simulation is self-consistent and properly comprehends thermodynamic limits. In this paper, we use rigorous photon recycling simulation coupled with carrier transport simulation to identify the dominant loss mechanisms that limit the performance of thin-film GaAs solar cells.
CISH is induced during DC development and regulates DC‐mediated CTL activation (2011)

The cytokine inducible SH2-domain protein (CISH) is a well-known STAT5 target gene, but its role in the immune system remains uncertain. In this study, we found that CISH is predominantly induced during dendritic cell (DC) development from mouse bone marrow (BM) cells and plays a crucial role in type 1 DC development and DC-mediated CTL activation. CISH knockdown reduced the expression of MHC class I, co-stimulatory molecules and pro-inflammatory cytokines in BMDCs. Meanwhile, the DC yield was markedly enhanced by CISH knockdown via cell-cycle activation and reduction of cell apoptosis. Down-regulation of cell proliferation at the later stage of DC development was found to be associated with CISH-mediated negative feedback regulation of STAT5 activation. In T-cell immunity, OT-1 T-cell proliferation was significantly reduced by CISH knockdown in DCs, whereas OT-2 T-cell proliferation was not affected by CISH knockdown. CTLs generated by DC vaccination were also markedly reduced by CISH knockdown, followed by significant impairment of DC-based tumor immunotherapy. Taken together, our data suggest that CISH expression at the later stage of DC development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.
Gain in Transcriptional Activity by Primate-specific Coevolution of Melanoma Antigen-A11 and Its Interaction Site in Androgen Receptor (2011)

Male sex development and growth occur in response to high affinity androgen binding to the androgen receptor (AR). In contrast to complete amino acid sequence conservation in the AR DNA and ligand binding domains among mammals, a primate-specific difference in the AR NH(2)-terminal region that regulates the NH(2)- and carboxyl-terminal (N/C) interaction enables direct binding to melanoma antigen-A11 (MAGE-11), an AR coregulator that is also primate-specific. Human, mouse, and rat AR share the same NH(2)-terminal (23)FQNLF(27) sequence that mediates the androgen-dependent N/C interaction. However, the mouse and rat AR FXXLF motif is flanked by Ala(33) that evolved to Val(33) in primates. Human AR Val(33) was required to interact directly with MAGE-11 and for the inhibitory effect of the AR N/C interaction on activation function 2 that was relieved by MAGE-11. The functional importance of MAGE-11 was indicated by decreased human AR regulation of an androgen-dependent endogenous gene using lentivirus short hairpin RNAs and by the greater transcriptional strength of human compared with mouse AR. MAGE-11 increased progesterone and glucocorticoid receptor activity independently of binding an FXXLF motif by interacting with p300 and p160 coactivators. We conclude that the coevolution of the AR NH(2)-terminal sequence and MAGE-11 expression among primates provides increased regulatory control over activation domain dominance. Primate-specific expression of MAGE-11 results in greater steroid receptor transcriptional activity through direct interactions with the human AR FXXLF motif region and indirectly through steroid receptor-associated p300 and p160 coactivators.
Dimethylarginine Dimethylaminohydrolase-1 Transgenic Mice Are Not Protected from Ischemic Stroke (2009)

Our study demonstrates that hDDAH-1 transgenic mice are not protected from ischemic cerebral tissue damage in tMCAO. This lack of protection is due to high basal cerebral DDAH activity, which is not further increasable by transgenic overexpression of DDAH.
Rhythmic TMS Causes Local Entrainment of Natural Oscillatory Signatures (2011)

The periodic electromagnetic force that is generated during rhythmic TMS can cause local entrainment of natural brain oscillations, emulating oscillatory signatures activated by cognitive tasks. This reveals a new mechanism of online TMS action on brain activity and can account for frequency-specific behavioral TMS effects at the level of biologically relevant rhythms.
The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type (1989)

Nicotine in patients with dementia of the Alzheimer type (DAT) produced a significant and marked improvement in discriminative sensitivity and reaction times on a computerised test of attention and information processing. Nicotine also improved the ability of DAT patients to detect a flickering light in a critical flicker fusion test. These results suggest that nicotine may be acting on cortical mechanisms involved in visual perception and attention, and support the hypothesis that acetylcholine transmission modulates vigilance and discrimination. Nicotine may therefore be of some value in treating deficits in attention and information processing in DAT patients.
Formaldehyde (2016)

The article contains sections titled: 1. Introduction 2. Physical Properties 2.1. Monomeric Formaldehyde 2.2. Aqueous Solutions 3. Chemical Properties 4. Production 4.1. Silver Catalyst Processes 4.1.1. Complete Conversion of Methanol (BASF Process) 4.1.2. Incomplete Conversion and Distillative Recovery of Methanol 4.2. Formox Process 4.3. Comparison of Process Economics 4.4. Distillation of Aqueous Formaldehyde Solutions 4.5. Preparation of Liquid Monomeric Formaldehyde 5. Environmental Protection 6. Quality Specifications and Analysis 6.1. Quality Specifications 6.2. Analysis 7. Storage and Transportation 8. Uses 9. Economic Aspects 10. Toxicology and Occupational Health 11. Low-Molecular-Mass Polymers 11.1. Linear Polyoxymethylenes 11.2. Cyclic Polyoxymethylenes 11.2.1. Trioxane 11.2.2. Tetraoxane 11.2.3. Higher Cyclic Polyoxymethylenes 12. Formaldehyde Cyanohydrin
Quasi-planar FinFETs with selectively grown germanium raised source/drain (2002)

Double-gate MOSFETs are attractive because they can be scaled to the shortest gate length for a given gate oxide thickness. Recent studies suggest that double gate devices can meet performance requirements down to 10 nm gate length. The FinFET was introduced and is a promising double-gate structure. A simplified, quasi-planar version of the FinFET exhibiting, excellent performance was presented. Short channel effects can be suppressed in the FinFET provided that the gate length is at least 1.4 times the fin thickness. The source/drain (S/D) thin fin extension regions are highly resistive so it is essential to minimize the length of the S/D thin fin extensions. In this work, we combine the simplicity of the new FinFET process flow with a selective Ge growth technique to present the first raised S/D quasi-planar FinFET devices.
Simple self-selective method of velocity measurement for particles in impact-based deposition (2000)

A simple, low-cost technique for particles velocity measurement in the gas deposition method (GDM) is reported. The accuracy of the technique is determined only by the precision of measurements of geometrical sizes of deposited pattern. Self-selection of the particles with parameters acceptable for deposition occurs. Under typical deposition conditions the velocities about 200 m/s for ceramic particles and up to 650 m/s for metal ones were detected. The proposed technique allows in situ monitoring during deposition both by GDM and by other deposition methods.
Astrocyte–endothelial interactions and blood–brain barrier permeability* (2002)

The blood-brain barrier (BBB) is formed by brain endothelial cells lining the cerebral microvasculature, and is an important mechanism for protecting the brain from fluctuations in plasma composition, and from circulating agents such as neurotransmitters and xenobiotics capable of disturbing neural function. The barrier also plays an important role in the homeostatic regulation of the brain microenvironment necessary for the stable and co-ordinated activity of neurones. The BBB phenotype develops under the influence of associated brain cells, especially astrocytic glia, and consists of more complex tight junctions than in other capillary endothelia, and a number of specific transport and enzyme systems which regulate molecular traffic across the endothelial cells. Transporters characteristic of the BBB phenotype include both uptake mechanisms (e.g. GLUT-1 glucose carrier, L1 amino acid transporter) and efflux transporters (e.g. P-glycoprotein). In addition to a role in long-term barrier induction and maintenance, astrocytes and other cells can release chemical factors that modulate endothelial permeability over a time-scale of seconds to minutes. Cell culture models, both primary and cell lines, have been used to investigate aspects of barrier induction and modulation. Conditioned medium taken from growing glial cells can reproduce some of the inductive effects, evidence for involvement of diffusible factors. However, for some features of endothelial differentiation and induction, the extracellular matrix plays an important role. Several candidate molecules have been identified, capable of mimicking aspects of glial-mediated barrier induction of brain endothelium; these include TGFbeta, GDNF, bFGF, IL-6 and steroids. In addition, factors secreted by brain endothelial cells including leukaemia inhibitory factor (LIF) have been shown to induce astrocytic differentiation. Thus endothelium and astrocytes are involved in two-way induction. Short-term modulation of brain endothelial permeability has been shown for a number of small chemical mediators produced by astrocytes and other nearby cell types. It is clear that endothelial cells are involved in both long- and short-term chemical communication with neighbouring cells, with the perivascular end feet of astrocytes being of particular importance. The role of barrier induction and modulation in normal physiology and in pathology is discussed.
Immunogenicity and Therapeutic Efficacy of a Dual-Component Genetic Cancer Vaccine Cotargeting Carcinoembryonic Antigen and HER2/ neu in Preclinical Models (2013)

Several cancer vaccine efforts have been directed to simultaneously cotarget multiple tumor antigens, with the intent to achieve broader immune responses and more effective control of cancer growth. Genetic cancer vaccines based on in vivo muscle electro-gene-transfer of plasmid DNA (DNA-EGT) and adenoviral vectors represent promising modalities to elicit powerful immune responses against tumor-associated antigens (TAAs) such as carcinoembryonic antigen (CEA) and human epidermal growth factor receptor-2 (HER2)/neu. Combinations of these modalities of immunization (heterologous prime-boost) can induce superior immune reactions as compared with single-modality vaccines. We have generated a dual component-dual target genetic cancer vaccine consisting of a DNA moiety containing equal amounts of two plasmids, one encoding the extracellular and transmembrane domains of HER2 (ECD.TM) and the other encoding CEA fused to the B subunit of Escherichia coli heat-labile toxin (LTB), and of an adenoviral subtype 6 dicistronic vector carrying the same two tumor antigens gene constructs. The CEA/HER2 vaccine was tested in two different CEA/HER2 double-transgenic mouse models and in NOD/scid-DR1 mice engrafted with the human immune system. The immune response was measured by enzyme-linked immunospot assay, flow cytometry, and ELISA. The CEA/HER2 vaccine was able to break immune tolerance against both antigens. Induction of a T cell and antibody immune response was detected in immune-tolerant mice. Most importantly, the vaccine was able to slow the growth of HER2/neu⁺ and CEA⁺ tumors. A significant T cell response was measured in NOD/scid-DR1 mice engrafted with human cord blood cells. In conclusion, the CEA/HER2 genetic vaccine was immunogenic and able to confer significant therapeutic effects. These data warrant the evaluation of this vaccination strategy in human clinical trials.
Investigating City Characteristics Based on Community Profiling in LBSNs (2012)

While the detection of social subgroups (i.e., communities) has always been a fundamental task in social network analysis, few efforts has been made to characterize the detected community. Meanwhile, to effectively facilitate applications based on the community structure, it is very important to understand the features of each community. Thereby, a systematic community profiling mechanism is needed. With the recent surge of location-based social networks (LBSNs, e.g., Foursquare, Facebook Places), huge amount of digital footprints about users' locations, profiles as well as their online social connections provide sufficient metadata for community profiling. Different from social networks (e.g., Flickr, Facebook) which have explicit groups for users to subscribe or join, LBSNs usually have no explicit community structure. In order to capitalize on the large number of potential users, quality community detection and profiling approaches are needed so as to enable applications such as direct marketing, group tracking, etc. In this paper, based on the user-venue check-in relationship and user/venue attributes, we come out with a novel community profiling framework. Specifically, we first adopt edge-clustering to simultaneously group both users and venues into communities, and then based on the rich metadata of users and venues we put forward a quantitative community profiling mechanism to indicate the preferences, interests and habits of a community. The efficacy of our approach is validated by intensive empirical evaluations using the collected Foursquare dataset of 266,838 users with 9,803,764 check-ins over 2,477,122 venues worldwide.
All-solid-state hybrid solar cells based on a new organometal halide perovskite sensitizer and one-dimensional TiO2 nanowire arrays (2013)

A novel organometal halide perovskite (CH3NH3PbI2Br) is synthesized and used as a visible light absorber to sensitize one-dimensional (1D) TiO2 nanowire arrays (NWAs) for all-solid-state hybrid solar cells. It achieved a power conversion efficiency (PCE) of 4.87% and an open circuit voltage (Voc) of 0.82 V, both higher than those of its analogue CH3NH3PbI3.
Downregulation of Connexin 43 Expression by High Glucose Reduces Gap Junction Activity in Microvascular Endothelial Cells (2002)

Impairment of retinal vascular homeostasis is associated with the development and progression of diabetic retinopathy involving gap junction intercellular communication (GJIC) activity. The principal gap junction protein of intercellular communication, connexin, was investigated to determine the effects of high glucose concentrations on the expression of endothelial-specific connexins (Cx37, Cx40, and Cx43), connexin phosphorylation pattern, and GJIC activity. Rat microvascular endothelial (RME) cells grown in high (30 mmol/l)-glucose medium for 9 days had reduced Cx43 expression: Cx43 mRNA (68 +/- 13% of control; P = 0.019, n = 5) and protein (55.6 +/- 16% of control; P = 0.003, n = 5) levels were reduced; however, Cx37 and Cx40 expression was not affected. Using alkaline phosphatase and Western blot analyses, we identified three forms of Cx43: a nonphosphorylated form (P0) and two phosphorylated forms (P1 and P2). Expression of all three forms was decreased in cells grown in high-glucose medium: PO, 73 +/- 15% of control (P = 0.04); P1, 57 +/- 16% of control (P = 0.01); and P2, 42 +/- 22% of control (P = 0.006). Using immunofluorescence microscopy, we observed Cx43 localization at specific sites of contact (plaques) between adjacent cells. In cells grown in high-glucose medium, we observed reduced plaque counts (63 +/- 6% of control; P = 0.009) and decreased intensity of Cx43 immunofluorescence compared with cells grown in normal medium. Furthermore, using scrape load dye transfer (SLDT) technique, we found that these cells exhibited reduced GJIC activity (60% of control; P = 0.01, n = 5). The reduction in GJIC activity correlated with the decreased Cx43 protein levels (r = 0.9). These results indicate that high glucose concentrations inhibited GJIC activity by reducing Cx43 synthesis in RME cells. Impaired intercellular communication may contribute to breakdown of homeostatic balance in diabetic microangiopathy.
Rational Design of a Topical Androgen Receptor Antagonist for the Suppression of Sebum Production with Properties Suitable for Follicular Delivery (2010)

A novel nonsteroidal androgen receptor antagonist, (R)-4-(1-benzyl-4,4-dimethyl-2-oxopyrrolidin-3-yloxy)-2-(trifluoromethyl)benzonitrile (1), for the topical control of sebum production is reported. This compound, which is potent, selective, and efficacious in the clinically validated golden Syrian hamster ear animal model, was designed to be delivered to the pilosebaceous unit, the site of action, preferentially by the follicular route.
“El último aldabonazo”: el drama político de Chibás y su representación en la prensa internacional (2017)

Eduardo Chibas was one of the most important politicians of the fifties in Cuba. Insightful and aggressive in his speeches, the way of his death supposed a shock in the island. In this paper, we try to show the media impact of this decease outside of Cuba, in the rest of the world. The importance of Eduardo Chibas dead is not limited to the disappearance of an extraordinary politician, the suicide and the reasons behind this suicide are very important too.
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell (2009)

The results of these studies demonstrate, for the first time, that OEA increases GLP-1 secretion from intestinal L-cells through activation of the novel GPR119 fatty acid derivate receptor in vitro and in vivo.
Fast 3D object recognition using multiple color coded illumination (2002)

The acquisition and measurement of two- and three-dimensional contours of objects are important tasks in modern production processes and quality control. Specially, nontactile methods like optical triangulation and the digital image processing are becoming more and more important. Color image processing in combination with color coded illumination could be used to realize new methods of nontactile 3D-object ranging. Two of these methods are the color-coded triangulation and the color-coded phase-shift method. We use a combination of these two methods to realize a fast 3D-object ranging with unambiguous results. The color-coded phase-shift method is able to reach a good spatial resolution, but the measured range values are ambiguous. Using color-coded triangulation an unambiguous three-dimensional image could be achieved, but compared to the color-coded phase-shift method, the spatial resolution is poor. Since both methods are able to generate a 3D-object description by processing only a single RGB-image, it is possible to combine these two methods.