gebhart/patrepeval huggingface dataset:
Delegation Technologies: Environmental Scanning with Intelligent Agents (1991)

Abstract:Identification and evaluation of relevant trends and patterns are critical steps in an organization's business environment monitoring. Not surprisingly, the "experts" that perform this evaluation are seldom skilled in all the disciplines necessary to accomplish a thorough evaluation of the environmental indicators. While one expert may be skilled at recognizing the potential for political turmoil in a foreign nation, another at Motorola is skilled at recognizing how Japanese government deregulation is meant to complement the development of new products. Moreover, these experts often benefit from each other's skills and know ledge in assessing activity in the organization's environment. Often the interchange among variously skilled analysts becomes a distributed problem-solving activity that creates the high-quality, interdisciplinary analysis essential for an effective environmental monitoring activity. Problems in the environmental monitoring process often occur when a particular expertise, an agent in the problem-solving network, is unavailable, and knowledge from that domain does not playa role in the analysis. The focus of this paper is on the distribution of expertise and the sharing of knowledge in the critical process of environmental monitoring. A technical approach is adapted in this effort—an architecture and a prototype of "delegation technologies" are described that provide the capability of capturing, organizing, and distributing knowledge that may be used by experts in classifying patterns of qualitative indicators in the business environment. The redistribution of responsibilities through the delegation to, and coordination of, intelligent agents is examined.Key Words and Phrases: blackboard modeldelegation technologyenvironmental scanning Additional informationNotes on contributorsGregg ElofsonGregg Elofson is Assistant Professor of Computer Information Systems in the College of Business Administration at the University of Miami. He holds a Ph.D. in MIS from the University of Arizona. His research interests include the relationships between organizational learning, attention, design, and information technology; distributed decision making; and knowledge-based systems. He has published conference proceedings and book chapters, and has served as a staff scientist in the artifical intelligence architectures group for Science Applications International Corp., and as a consultant for Andersen Consulting.Benn KonsynskiBenn Konsynski is a Visiting Professor at the Harvard Business School. Prior to that he was a professor at the University of Arizona, where he was cofounder of the university's group decision support laboratory. He received his Ph.D. in computer science from Purdue University. His current research interests are organizational and information systems design issues. He has published in such diverse journals as Communications of the ACM, Harvard Business Review, IEEE Transactions on Communications; MIS Quarterly, Journal of Management Information Systems, among many others.
Intrastriatal Infusion of Liver Growth Factor Stimulates Dopamine Terminal Sprouting and Partially Restores Motor Function in 6-Hydroxydopamine-lesioned Rats (2005)

Liver growth factor (LGF) is a mitogen for liver cells that shows biological activity in extrahepatic sites and may be useful for neuroregenerative therapies. The aim of this work was to investigate the effects of the intrastriatal (IS) infusion of LGF in the 6-hydroxydopamine rat model of Parkinson's disease. Tyrosine hydroxylase-positive innervation was significantly increased in the dopamine-denervated striatum of rats receiving intrastriatal LGF infusions (160 ng/day/rat × 15 days) as compared with a vehicle-infused group. There was no evidence of dopaminergic neurogenesis in the striatum or substantia nigra in any experimental group at the times studied. However, in those animals undergoing IS-LGF infusion for 48 hr, we found a significant increase in both microglial proliferation and in the number of microglial cells that acquired the ameboid morphology. This is characteristic of activated microglia/macrophages that has been reported to play an important role in dopamine terminal sprouting. In summary, our study shows that IS infusion of LGF stimulates the outgrowth of tyrosine hydroxylase-positive terminals in the striatum of 6-hydroxydopamine-treated rats. As apomorphine-induced rotational behavior was also reduced in these animals, we propose LGF as a novel factor that, when delivered to the striatum, may be useful in the treatment of Parkinson's disease.
Tunable VCSEL (2000)

Vertical-cavity surface-emitting lasers (VCSELs) are now key optical sources in optical communications. Their main application is currently in local area networks using multimode optical fibers. VCSELs are also being rapidly commercialized for single-mode fiber metropolitan area and wide area network applications. The advantages of VCSEL include simpler fiber coupling, easier packaging and testing, and the ability to be fabricated in arrays. In addition, VCSELs have an inherent single-wavelength structure that is well suited for wavelength engineering. All these advantages promise to lead to cost-effective wavelength-tunable lasers, which are essential for the future intelligent, all-optical networks. The author reviews the advances on wavelength-tunable VCSELs. She summarizes some of the early breakthroughs in wavelength engineering of VCSELs and then concentrates on the designs and properties of micromechanical tunable VCSEL.
Peripheral levels of dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, and testosterone following different doses of danazol (1984)

Peripheral serum levels of dehydroepiandrosterone sulfate (DHAS), dehydroepiandrosterone (DHA), androstenedione (A4) and testosterone (T) were measured in two groups of premenopausal women with fibrocystic breast disease, given 200 and 400 mg of danazol a day respectively for 6 months. During treatment, DHAS levels increased and DHA, DHA/DHAS ratio, A4, and T decreased. A tendency towards dose dependency was observed. The changes in DHAS, DHA and DHA/DHAS ratio were interpreted as resulting from inhibition of liver sulfatase activity by danazol. The decreased A4 and T levels probably reflect a suppression of ovarian steroidogenesis due to enzyme inhibition by danazol, and for the latter steroid also and increased metabolism due to interaction of the drug with sex hormone-binding globulin.
In Vitro Analyses of the Effects of Heparin and Parabens on Candida albicans Biofilms and Planktonic Cells (2011)

Infections and thromboses are the most common complications associated with central venous catheters. Suggested strategies for prevention and management of these complications include the use of heparin-coated catheters, heparin locks, and antimicrobial lock therapy. However, the effects of heparin on Candida albicans biofilms and planktonic cells have not been previously studied. Therefore, we sought to determine the in vitro effect of a heparin sodium preparation (HP) on biofilms and planktonic cells of C. albicans. Because HP contains two preservatives, methyl paraben (MP) and propyl paraben (PP), these compounds and heparin sodium without preservatives (Pure-H) were also tested individually. The metabolic activity of the mature biofilm after treatment was assessed using XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] reduction and microscopy. Pure-H, MP, and PP caused up to 75, 85, and 60% reductions of metabolic activity of the mature preformed C. albicans biofilms, respectively. Maximal efficacy against the mature biofilm was observed with HP (up to 90%) compared to the individual compounds (P < 0.0001). Pure-H, MP, and PP each inhibited C. albicans biofilm formation up to 90%. A complete inhibition of biofilm formation was observed with HP at 5,000 U/ml and higher. When tested against planktonic cells, each compound inhibited growth in a dose-dependent manner. These data indicated that HP, MP, PP, and Pure-H have in vitro antifungal activity against C. albicans mature biofilms, formation of biofilms, and planktonic cells. Investigation of high-dose heparin-based strategies (e.g., heparin locks) in combination with traditional antifungal agents for the treatment and/or prevention of C. albicans biofilms is warranted.
Expression of Human -Lactalbumin in Transgenic Tobacco (1998)

alphaLA-Lactalbumin (alphaLA), a major milk protein, is the regulatory subunit of lactose synthase. To assess the production of recombinant alphaLA in plants, the cDNAs for human alphaLA with or without its own signal sequence were introduced into tobacco plants under the control of the cauliflower mosaic virus 35S promoter. The gene integration and expression at the mRNA level were confirmed in several regenerated plants, while the expression at the protein level could be confirmed only in a transgenic tobacco transformed with the gene containing the signal sequence. The tobacco-expressed alphaLA migrated in SDS-PAGE with identical mobility to alphaLA prepared from human milk, indicating that the signal peptide of human alphaLA was correctly processed to yield a mature protein in tobacco plants. The expressed alphaLA (ca. 5 microg/g of fresh leaves) was found in the soluble fraction and eluted from a DEAE-Sepharose column in the same salt concentration range as the milk alphaLA. The partially purified tobacco-alphaLA was fully active in the synthesis of lactose when combined with galactosyltransferase. Thus, the transgenic tobacco produces a fully active mature alphaLA in a soluble form.
Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity (2004)

Lipopolysaccharide (LPS) from the outer membrane of Gram-negative bacteria belongs to the most potent activators of the mammalian immune system. Its lipid moiety, lipid A, the 'endotoxic principle' of LPS, carries two negatively charged phosphate groups and six acyl chain residues in a defined asymmetric distribution (corresponding to synthetic compound 506). Tetraacyl lipid A (precursor IVa or synthetic 406), which lacks the two hydroxylated acyl chains, is agonistically completely inactive, but is a strong antagonist to bioactive LPS when administered to the cells before LPS addition. The two negative charges of lipid A, represented by the two phosphate groups, are essential for agonistic as well as for antagonistic activity and no highly active lipid A are known with negative charges other than phosphate groups. We hypothesized that the phosphate groups could be substituted by other negatively charged groups without changing the endotoxic properties of lipid A. To test this hypothesis, we synthesized carboxymethyl (CM) derivatives of hexaacyl lipid A (CM-506 and Bis-CM-506) and of tetraacyl lipid A (Bis-CM-406) and correlated their physicochemical with their endotoxic properties. We found that, similarly to compounds 506 and 406, also for their carboxymethyl derivatives a particular molecular ('endotoxic') conformation and with that, a particular aggregate structure is a prerequisite for high cytokine-inducing capacity and antagonistic activity, respectively. In other parameters such as acyl chain melting behaviour, antibody binding, activity in the Limulus lysate assay, and partially the binding of 3-deoxy-D-manno-oct-2-ulosonic acid transferase, strong deviations from the properties of the phosphorylated compounds were observed. These data allow a better understanding of endotoxic activity and its structural prerequisites.
A comparison of coping assessed by ecological momentary assessment and retrospective recall. (1998)

Recent research suggests that retrospective coping assessments may not correspond well with day-to-day reports. The authors extended this work by examining the correspondence between short-term (within 48 hr) retrospective coping reports and momentary reports recorded via a palm-top computer close in time to when the stressor occurred. There was relatively poor correspondence between the 2 assessments. Some reports of momentary coping were not reported retrospectively, and some coping reported retrospectively was not reported at the time the stressor occurred. Cognitive coping was more likely to be underreported retrospectively; behavior coping was overreported. Participants were consistent in their discrepancies, but there was no correspondence between discrepancy rates and demographic or personality variables.
Variability of the subthalamic nucleus: The case for direct MRI guided targeting (2007)

Because of concerns about direct visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI), many functional neurosurgeons continue to rely on atlas-based coordinates to reach this target. T2-weighted MRI does allow direct visualisation of the STN. In order to compare the coordinates of the target point within the visualised STN with those obtained from standard brain atlases, the preoperative stereotactic T2-weighted MRI used to implant 55 deep brain stimulation electrodes in the visualised STN of 29 consecutive patients with Parkinson's disease treated in two European centres were studied. The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus.
Intravenous immunoglobulins in the treatment of immune neuropathies (2008)

Intravenous immunoglobulin represents an effective and safe treatment option in patients with autoimmune-mediated diseases affecting the peripheral nerves.
Label‐free detection of DNA using field‐effect transistors (2006)

Abstract Electronic DNA sensors based on field‐effect transistor arrays operating in liquid environment, offer an alternative method for the detection of biomolecular binding events, without the requirement to label the target molecules. These semiconductor devices are sensitive to electrical charge variations that occur at the surface/electrolyte interface. Using such devices, the hybridization reaction of oligonucleotides with complementary single‐stranded oligonucleotides, which are immobilized on the oxide surface of the transistor gate, can be detected. The detection principle is based on the intrinsic charge of the nucleic acid molecules in liquid environment. In this article we present a summary of the ‘DNA BioFET’ project, which has been conducted in our group in recent years. We compare an electrostatic and a covalent immobilization protocol for the probe DNA. Most important for reliable signal readout is the use of a differential approach, for which a DNA microarray represents an ideal bioassay. With our FET setup we can either use a chip‐to‐chip reference with two electrically identical chips, which are coated with different probe sequences. A more sophisticated method, which makes use of the DNA microarray technology, was established with an aligned microspotting system enabling the coating of different channels out of the microarray with different probe sequences. So far our current chip design uses 16 channels enabling first proof‐of‐principle experiments. The detection method itself, however, offers the possibility to be up scaled to many thousands of sensor spots like currently used in fluorescence based DNA microarray chips. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
βPix-enhanced p38 Activation by Cdc42/Rac/PAK/MKK3/6-mediated Pathway (2001)

betaPix (PAK-interacting exchange factor) is a recently identified guanine nucleotide exchange factor for Rho family small G protein Cdc42/Rac. The protein interacts with p21-activated protein kinase (PAK) through its SH3 domain. We examined the effect of betaPix on MAP kinase signaling and cytoskeletal rearrangement in NIH3T3 fibroblast cells. Overexpression of betaPix enhanced the activation of p38 in the absence of other stimuli and also induced translocation of p38 to the nucleus. This betaPix-induced p38 activation was blocked by coexpression of dominant-negative Cdc42/Rac or kinase-inactive PAK, indicating that the effect of betaPix on p38 is exerted through the Cdc42/Rac-PAK pathway and requires PAK kinase activity. The essential role of betaPix in growth factor-stimulated p38 activation was evidenced by the blocking of platelet-derived growth factor-induced p38 activation in the cells expressing betaPix SH3m (W43K) and betaPix DHm (L238R,L239R). In addition, SB203580, a p38 inhibitor, and kinase-inactive p38 (T180A,Y182F) blocked membrane ruffling induced by betaPix, suggesting that p38 might be involved in mediating betaPix-induced membrane ruffling. The results in this study suggest that betaPix might have a role in nuclear signaling, as well as in actin cytoskeleton regulation, and that some part of these cellular functions is possibly mediated by p38 MAP kinase.
BREAST CANCER (2019)

Breast cancer is the most common type of cancer found in women, and the second leading cause of cancer deaths. There are several well-known risk factors for the development of breast cancer including, age, menstrual and pregnancy history, genetic mutations, abnormalities in cells, breast density, obesity, and radiation therapy to the chest area. There are a few tools that can be used to help clinicians understand an individual's risk for breast cancer. These tools use a variety of factors to calculate risk. The purpose of screening is to detect breast cancer at an early stage, which is generally associated with a better prognosis. Breast imaging in the form of a mammogram is the usual modality for breast cancer screening. Breast cancer prevention efforts can be divided into several groups: lifestyle modification, chemoprevention, and surgical prevention. The advances have led to more patients surviving breast cancer and thus the need to address issues related to survivorship.
Metal halide perovskite nanomaterials: synthesis and applications (2016)

Nanomaterials refer to those with at least one dimension being at the nanoscale (<i>i.e.</i> <100 nm) such as quantum dots, nanowires, and nanoplatelets. These types of materials normally exhibit optical and electrical properties distinct from their bulk counterparts due to quantum confinement or strong anisotropy. In this perspective, we will focus on a particular material family: metal halide perovskites, which have received tremendous interest recently in photovoltaics and diverse photonic and optoelectronic applications. The different synthesis approaches and growth mechanisms will be discussed along with their novel characteristics and applications. Taking perovskite quantum dots as an example, the quantum confinement effect and high external quantum efficiency are among these novel properties and their excellent performance in applications, such as single photon emitters and LEDs, will be discussed. Understanding the mechanism behind the formation of these nanomaterial forms of perovskite will help researchers to come up with effective strategies to combat the emerging challenges of this family of materials, such as stability under ambient conditions and toxicity, towards next generation applications in photovoltaics and optoelectronics.
Hydroxychloroquine Blood Levels in Systemic Lupus Erythematosus: Clarifying Dosing Controversies and Improving Adherence (2015)

There was a trend toward higher disease activity with lower HCQ levels. Renal failure dosing led to suboptimum levels. We show that weight-based dosing (max 400 mg daily) is appropriate and that height does not appear to influence levels. Measurement, counseling, and repeated testing can increase adherence rates.
Prohibitin 3' untranslated region polymorphism and breast cancer risk. (2003)

Prohibitin is an antiproliferative protein [(1)][1] and may function as a tumor suppressor through interaction with the retinoblastoma tumor suppressor protein and its family members [(2)][2] . In addition, somatic mutations have been identified in human cancers, including breast cancer [(3][3] [, 4
Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat (1992)

We examined the role of C activation in ischemia reperfusion injury by inhibiting C activation in a rat model of mesenteric arterial occlusion. In anesthetized rats, 60 min of mesenteric arterial occlusion was followed by 3 h of reperfusion. PBS alone or containing soluble C receptor 1 (3 or 6 mg) was administered i.v. Controls underwent laparotomy without ischemia. Relative serum C activities were assessed by hemolytic assay, neutrophil (polymorphonuclear leukocyte) sequestration by tissue content of myeloperoxidase (MPO) activity, intestinal mucosal injury by histologic grading, lung vascular permeability by the ratio of bronchoalveolar lavage to blood concentration of radiolabeled BSA, and endothelial cell injury was quantified by measurement of plasma factor VIII-related Ag. After reperfusion, PBS-treated animals had increased intestinal MPO (0.048 +/- 0.007 U/g) compared to sham (0.022 +/- 0.005 U/g (p less than 0.05)) and intestinal mucosal injury score (2.490 +/- 0.221) compared to sham (0.331 +/- 0.045 (p less than 0.05)). Treatment with 6 mg soluble C receptor 1 15 min before reperfusion reduced intestinal MPO (0.017 +/- 0.003 U/g (p less than 0.05)) and mucosal injury (1.733 +/- 0.168 (p less than 0.05)) compared to PBS control. PBS-treated animals also demonstrated increased lung MPO (0.314 +/- 0.025 U/g vs 0.085 +/- 0.018 in sham (p less than 0.05)) and increased lung permeability (bronchoalveolar lavage/blood cpm 11.32 +/- 1.35 x 10(-3) vs sham 2.22 +/- 0.19 x 10(-3) (p less than 0.05)). Treatment with 6 mg soluble C receptor 1 15 min before reperfusion or at reperfusion reduced the lung permeability (bronchoalveolar lavage/blood cpm 3.90 +/- 0.79 x 10(-3) and 5.08 +/- 0.75, respectively (both p less than 0.05)) compared to PBS control, but did not reduce lung MPO (0.342 +/- 0.031 U/g and 0.246 +/- 0.025), respectively. Treatment with sCR1 also reduced the release of factor VIII-related Ag, 5-day mortality, and C hemolytic activity. In this model, C is a major mediator of intestinal injury and extraintestinal injury.
A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins (1988)

The gene encoding an immunologically important 18-kilodalton protein antigen of Mycobacterium leprae has been sequenced, and the amino acid sequence of the antigen has been deduced. The 18-kilodalton antigen is strikingly similar in size and sequence to a family of eucaryotic heat shock proteins.
Trends in late-stage breast, cervical and colorectal cancers in blacks and whites. (2000)

Some progress toward black-white equity in stage at diagnosis was evident, consistent with reported trends in use of screening tests, but further surveillance and research are needed.