gebhart/patrepeval huggingface dataset:
Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. (1990)

We have quantitated in adult and developing rat tissues the molar concentrations of c-erbA alpha 1- and beta 1-mRNAs, which code for nuclear T3-binding proteins, and c-erbA alpha 2-mRNA, which is generated by alternate splicing of the alpha gene transcript and codes for a receptor variant that does not bind T3. Comparison of the concentrations of c-erbA alpha 1-mRNA, beta 1-mRNA, or their sum to the T3 nuclear binding capacity per mg of DNA in adult liver, kidney, heart, cerebrum, and cerebellum and during the ontogeny of liver and brain shows that the T3 binding capacity/c-erbA mRNA ratio is tissue-specific and related to developmental state. Administration of T3 resulted in a 40-50% fall in the alpha 1 signal of adult liver, kidney, and heart without changing either the beta 1 signal or T3 binding capacity. A 40-fold increase in rat brain beta 1-mRNA occurred in the transition between the 19-day gestational fetus and the 10-day-old neonate. This corresponds to the period during which the T3 content rises in brain and during which T3 is known to influence central nervous system development. Our findings indicate that important translational or post-translational factors influence nuclear binding capacity and raise the possibility that c-erbA beta 1 may play a primary role in mediating T3 effects in developing and adult animals.
α1 and α2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression (1999)

Tumor cell invasion relies on cell migration and extracellular matrix proteolysis. We investigated the contribution of different integrins to the invasive activity of mouse mammary carcinoma cells. Antibodies against integrin subunits α6 and β1, but not against α1 and α2, inhibited cell locomotion on a reconstituted basement membrane in two-dimensional cell migration assays, whereas antibodies against β1, but not against α6 or α2, interfered with cell adhesion to basement membrane constituents. Blocking antibodies against α1 integrins impaired only cell adhesion to type IV collagen. Antibodies against α1, α2, α6, and β1, but not α5, integrin subunits reduced invasion of a reconstituted basement membrane. Integrins α1 and α2, which contributed only marginally to motility and adhesion, regulated proteinase production. Antibodies against α1 and α2, but not α6 and β1, integrin subunits inhibited both transcription and protein expression of the matrix metalloproteinase stromelysin-1. Inhibition of tumor cell invasion by antibodies against α1 and α2 was reversed by addition of recombinant stromelysin-1. In contrast, stromelysin-1 could not rescue invasion inhibited by anti-α6 antibodies. Our data indicate that α1 and α2 integrins confer invasive behavior by regulating stromelysin-1 expression, whereas α6 integrins regulate cell motility. These results provide new insights into the specific functions of integrins during tumor cell invasion.
Paroxysmal atrial fibrillation is associated with increased intra-atrial conduction delay (2008)

Comparison of PAF and non-AF patient groups showed that intra-atrial conduction delay start in the PAF group earlier (with longer S1S2 intervals) and they are significantly longer in the PAF group. This suggests that atria in patients with PAF are diffusely diseased and that the measured activation delays form one component of an arrhythmogenic substrate.
A rational reconstruction of INTERNIST-I using PROTEGE-II. (1995)

PROTEGE-II is a methodology and a suite of tools that allow developers to build and maintain knowledge-based systems in a principled manner. We used PROTEGE-II to reconstruct the well-known INTERNIST-I system, demonstrating the role of a domain ontology (a framework for specification of a model of an application area), a reusable problem-solving method, and declarative mapping relations in creating a new, working program. PROTEGE-II generates automatically a domain-specific knowledge-acquisition tool, which, in the case of the INTERNIST-I reconstruction, has much of the functionality of the QMR-KAT knowledge-acquisition tool. This study provides a means to understand better both the PROTEGE-II methodology and the models that underlie INTERNIST-I.
Amino acid sequence of human respiratory syncytial virus nucleocapsid protein (1983)

Amino acid sequence of the human respiratory syncytial (RS) virus nucleocapsid (NC) protein, deduced from the DNA sequence of a recombinant plasmid, is presented. The cDNA plasmid (pRSB11) has 1412 bp of RS viral NC sequence and lacks six nucleotides of the 5' end of mRNA. There is a single long open reading frame encoding 467 amino acids. This 51540 dal protein is rich in basic amino acids and has no homologies with other known viral capsid proteins.
Band Gap Energy and Band Lineup of III-V Alloy Semiconductors Incorporating Nitrogen and Boron (1993)

The band gap energy and band lineup of 15 binary, 42 ternary and 39 quaternary III-V alloy semiconductors composed of (B, Al, Ga, In)(N, P, As, Sb) are calculated by mean of the dielectric method of Van Vechten and the Harrison model, respectively. The alloys including N are predicted to have negative band gap energy in most of the compositional range due to the large electro-negativity of nitrogen atom. Possible material combinations for a lattice-matched doubleheterostructure for blue-light-emitting devices are discussed. The chart presented here will be useful in designing blue-to-ultraviolet light emitters with and without strain in the devices
Paramyxoviridae (1978)

Positive-muon behavior in magnetite is investigated by the muon-spin-rotation technique. The observed muon relaxation rate in zero applied field, in conjunction with the measured local field, allows us to separate muon-motion effects from phase transitions associated with magnetite. The local magnetic field is observed to be 4.02 kOe directed along the axis, the easy axis of magnetization. Possible origins of this field are discussed in terms which include local muon diffusion and a supertransfer hyperfine interaction resulting from muon-oxygen bonding. An anomaly in the muon hyperfine interactions is observed at 247 K.
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene (1997)

To examine the physiological role of the Fyn tyrosine kinase in neurons, we generated transgenic mice that expressed a fyn cDNA under the control of the calcium/calmodulin-dependent protein kinase IIalpha promoter. With this promoter, we detected only low expression of Fyn in the neonatal brain. In contrast, there was strong expression of the fyn-transgene in neurons of the adult forebrain. To determine whether the impairment of long-term potentiation (LTP) observed in adult fyn-deficient mice was caused directly by the lack of Fyn in adult hippocampal neurons or indirectly by an impairment in neuronal development, we generated fyn-rescue mice by introducing the wild-type fyn-transgene into mice carrying a targeted deletion in the endogenous fyn gene. In fyn-rescue mice, Schaffer collateral LTP was restored, even though the morphological abnormalities characteristic of fyn-deficient mice were still present. These results suggest that Fyn contributes, at least in part, to the molecular mechanisms of LTP induction.
Controlled Synthesis and Luminescence of Lanthanide Doped NaYF4 Nanocrystals (2007)

A range of nearly monodispersed NaYF4 single-crystal nanorods, hexagonal nanoplates, and nanoparticles have been successfully prepared via a facile wet chemical technology. Varying the dopants leads to different luminescence. These as-prepared nanocrystals not only present novel room-temperature downconversion (DC) and upconversion (UC) fluorescence but can also be transparently dispersed in cyclohexane. The effects of reaction temperature and time, doped ion concentration, ratio of NaF to Ln(NO3)3, and the reactant content on the shape, size, and crystal phase purity of the as-prepared nanocrystals have been investigated in detail. The fluorescence photos, spectra, luminescence mechanism, and the formation mechanism of the nanorods have also been demonstrated. For the next biolabel applications, the colloidal nanoparticles dispersed in cyclohexane have also been transferred into water by surface silane modification. For their unique DC and UC luminescence and high processability, these nanocrystals will open new avenues in biolabels, light-emitting diodes (LEDs), color displays, anti-counterfeiting, and solid-state lasers.
Brief introduction of 10 species of Stigmella (Lepidoptera , Nepticulidae) on Fagaceae in China (2001)

Nepticulidae , a family of very small Microlepidoptera with mostly leafmining larvae, was hitherto almost unknown from the territories of the People' s Republic of China. In this paper we'll treat 10 species of the genus Stigmella reared from hosts belonging to Fagaceae (oaks).
The biology and technology of the cultivated mushroom. (1985)

Methods of producing the cultivated mushroom, Agaricus bisporus, have advanced dramatically over the past decade, and for the most part improvements in technology have been generated by fundamental advances in our understanding of the basic biology of the crop. This book, in one well-structured and comprehensive volume, draws together this important research work, and represents the cumulative knowledge and experience of one of the world's leading mushroom research teams. The multi-authored approach has encouraged the comprehensive treatment of a topic within a chapter, but strong editing has equally emphasised the many overlaps and links between topics. Aspects discussed include the history, general biology, cultural systems, nutrition, biochemistry, genetics, growth, fruiting, food value and chemical composition of the mushroom. Sections of special value to growers will include compost preparation, spawn production, crop productivity, post-harvest storage and the chapters on pests and bacterial, fungal and viral pathogens. The whole book is very extensively referenced.
Antacids vs placebos in peptic ulcer therapy. A controlled double-blind investigation (1973)

The ability of an antacid preparation to relieve discomfort and to promote healing of peptic ulceration was compared to a placebo in a controlled double-blind outpatient study. Antacids were more effective than placebos in the promotion of healing (<i>P</i>=.04) and relief of discomfort (<i>P</i>=.03) of gastric ulcerations. In duodenal ulceration, a trend in favor of antacid therapy was found with respect to promotion of healing and relief of peptic discomfort. This trend, however, was not statistically significant (<i>P</i>&gt;.15).
High-quality tailored-edge cleaving using aberration-corrected Bessel-like beams (2018)

We report on the usage of ultrashort laser pulses in the form of aberration-corrected Bessel-like beams for laser cutting of glass with bevels. Our approach foresees inclining the material's entrance surface with respect to the processing optics. The detailed analysis of phase distortions caused by the beam transition through the tilted glass surface allows precompensating for occurring aberrations using digital holography. We verify theoretical considerations by means of pump-probe microscopy and present high-quality edges in nonstrengthened silicate glass.
A user centric mobility prediction approach based on spatial conceptual maps (2005)

This paper presents a novel framework for user mobility prediction that can accurately predict the traveling trajectory and destination using knowledge of user's preferences, goals, and analyzed spatial information without imposing any assumptions about the availability of users' movements history. Using concepts of evidential reasoning of Dempster-Shafer's theory, the user's navigation behavior is captured by gathering pieces of evidence concerning different groups of candidate future locations. These groups are then refined to predict the user's future location when evidence accumulate using Dempster rule of combination. Simulation results are presented to demonstrate the performance of the proposed framework.
Brain Injuries Among Infants, Children, Adolescents, and Young Adults (1990)

Blunt and penetrating force injuries to the brain constitute an enormous public health problem. If a child or young adult survives a moderate or severe brain injury, there is a strong likelihood of a lifetime of physical and mental impairment as well as tremendous economic and social impact on the family. The magnitude of this problem has only been recently appreciated, yet many questions on the causes and short- or long-term outcomes remain unanswered. One conclusion is clear: prevention is the best solution, but information on the nature of the brain injury, exposure factors, and effectiveness of countermeasures is incomplete. We sought to summarize certain basic epidemiological data on brain injuries in infants, children, adolescents, and young adults as well as findings on incidence of brain injury and current data on demographics and risk factors. We also estimated disability and person-years of life lost from brain injuries and highlight the value of helmets as a countermeasure for several exposures to head injury.
MUTANTS OF YEAST DEFECTIVE IN SUCROSE UTILIZATION (1981)

Utilization of sucrose as a source of carbon and energy in yeast (Saccharomyces) is controlled by the classical SUC genes, which confer the ability to produce the sucrose-degrading enzyme invertase (Mortimer and Hawthorne 1969). Mutants of S. cerevisiae strain S288C (SUC2+) unable to grow anaerobically on sucrose, but still able to use glucose, were isolated. Two major complementation groups were identified: twenty-four recessive mutations at the SUC2 locus (suc2-); and five recessive mutations defining a new locus, SNF1 (for sucrose nonfermenting), essential for sucrose utilization. Two minor complementation groups, each comprising a single member with a leaky sucrose-nonfermenting phenotype, were also identified. The Suc2 mutations isolated include four suppressible amber mutations and five mutations apparently exhibiting intragenic complementation; complementation analysis and mitotic mapping studies indicated that all of the suc2 mutations are alleles of a single gene. These results suggest that SUC2 encodes a protein, probably a dimer or multimer. No invertase activity was detected in suc2 probably a dimer or multimer. No invertase activity was detected in suc2 mutants,--The SNF1 locus is not tightly linked to SUC2. The snf1 mutations were found to be pleiotropic, preventing sucrose utilization by SUC2+ and SUC7+ strains, and also preventing utilization of galactose, maltose and several nonfermentable carbon sources. Although snf1 mutants thus display a petite phenotype, classic petite mutations do not interfere with utilization of sucrose, galactose or maltose. A common feature of all the carbon utilization systems affected by SNF1 is that all are regulated by glucose repression. The snf1 mutants were found to produce the constitutive nonglycosylated form of invertase, but failed to produce the glucose-repressible, glycosylated, secreted invertase. This failure cannot be attributed to a general defect in production of glycosylated and secreted proteins because synthesis of acid phosphatase, a glycosylated secreted protein not subject to glucose repression, was not affected by snf1 mutations. These findings suggest that the SNF1 locus is involved in the regulation of gene expression by glucose repression.
Ler João do Rio: Um pacto interdisciplinar (2000)

Based on studies in the history of social anthropology and urbanism, we intend  to demonstrate how Joao do Rio's decadentist matrices promote a reaction to the disciplinary postulates imposed by the urban reform of Rio de Janeiro in the beginning of the 20th century.
A 62mV 0.13&#x03BC;m CMOS standard-cell-based design technique using schmitt-trigger logic (2011)

In this paper, the authors demonstrate a standard cell-based circuit technique fully operational at supply voltages between 84 mV and 62 mV in standard 0.13 μm bulk CMOS depending on the area overhead invested. Supply voltage reduction is limited by the degradation of the on/off current-ratio of CMOS transistors with decreasing V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> , causing the leakage currents through the off transistors to be on the same order of magnitude as the drive currents. The result is an output level degradation of logic gates due to a voltage divider-like behavior, an effect emphasized by process variability. In this work, the output level degradation is mitigated by the use of Schmitt trigger structures, which exhibit an effective leakage quenching in the off-path of a gate and have been proposed for low-voltage RAM.
Prostate drug Proscar cleared for marketing (1992)

RETURN TO ISSUEPREVNewsNEXTProstate drug Proscar cleared for marketingSTEPHEN STINSONCite this: Chem. Eng. News 1992, 70, 26, 7Publication Date (Print):June 29, 1992Publication History Published online10 November 2010Published inissue 29 June 1992https://pubs.acs.org/doi/10.1021/cen-v070n026.p007ahttps://doi.org/10.1021/cen-v070n026.p007anewsACS PublicationsCopyright © 1992 AMERICAN CHEMICAL SOCIETYArticle Views6Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Anatomy Get e-Alerts
Metaphorical conceptualization from an ad hoc source concept (Conceptualización metafórica a partir de un concepto fuente ad hoc) (2021)

In this paper we explore the differences between several types of temporary conceptualization and the different ways of representing them verbally, and claim that, in the most creative or extended cases of metaphor, utterance interpretation involves a temporary conceptualization or temporary concept of the target domain. Unlike non-metaphorical temporary conceptualizations, metaphorical conceptualization requires a mechanism of cross-domain mapping (from source to target domain) and, in many of these cases, the source domain is already a temporary conceptualization of an ad hoc category, an ad hoc concept, and thus their interpretation involves a recursive temporary conceptualization.
Structure and Mechanism of Strength Enhancement in Interpenetrating Polymer Network Hydrogels (2011)

Hydrogels with high modulus and fracture strength are obtained by interpenetrating a tightly cross-linked poly(ethylene glycol) (PEG) network with a loosely cross-linked poly(acrylic acid) (PAA) network. Small-angle X-ray and neutron scattering (SAXS/SANS) are used in conjunction with swelling measurements to determine the structure of PEG/PAA interpenetrating polymer networks (IPNs) and to measure the average PEG chain extension within the IPN. At pH 7.4, the PEG chains within the IPN are extended to 45–70% of their maximum achievable length as a result of expansion of the ionized PAA network within the IPN. Near these high extension ratios, the force required to further strain the PEG chains is increased due to the entropic effects of finite chain extensibility. This leads to PEG/PAA IPN hydrogels with a 3-fold increase in both compressive modulus and fracture strength compared to PEG single networks with the same polymer volume fraction. The structure, mechanical properties, and mechanisms of strength enhancement for PEG/PAA IPN hydrogels are notably different than for the high toughness double-network hydrogels previously described by Gong et al.
Autologous protein solution inhibits MMP‐13 production by IL‐1β and TNFα‐stimulated human articular chondrocytes (2011)

Catabolic inflammatory cytokines are prevalent in osteoarthritis (OA). The purpose of this study was to evaluate an autologous protein solution (APS) as a potential chondroprotective agent for OA therapy. APS was prepared from platelet-rich plasma (PRP). The APS solution contained both anabolic (bFGF, TGF-β1, TGF-β2, EGF, IGF-1, PDGF-AB, PDGF-BB, and VEGF) and anti-inflammatory (IL-1ra, sTNF-RI, sTNF-RII, IL-4, IL-10, IL-13, and IFNγ) cytokines but low concentrations of catabolic cytokines (IL-1α, IL-1β, TNFα, IL-6, IL-8, IL-17, and IL-18). Human articular chondrocytes were pre-incubated with the antagonists IL-1ra, sTNF-RI, or APS prior to the addition of recombinant human IL-1β or TNFα. Following exposure to inflammatory cytokines, the levels of MMP-13 in the culture medium were evaluated by ELISA. MMP-13 production stimulated in chondrocytes by IL-1β or TNFα was reduced by rhIL-1ra and sTNF-RI to near basal levels. APS was also capable of inhibiting the production of MMP-13 induced by both IL-1β and TNFα. The combination of anabolic and anti-inflammatory cytokines in the APS created from PRP may render this formulation to be a potential candidate for the treatment of inflammation in patients at early stages of OA.
Transgenic engineering of male-specific muscular hypertrophy (2005)

Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows.
Loading of a DNA helicase on the DNA unwinding element in the yeast replication origin: Mechanism of DNA replication in a model system (1994)

We found that initiation of DNA replication occurs from the region containing the yeast autonomously replicating sequence 1 (ARS1), by incubating negatively supercoiled plasmid DNA with the proteins required for SV40 DNA replication in addition to DNA gyrase (Ishimi, Y., & Matsumoto, K. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 5399-5403). Here, the mechanism of DNA replication and the roles of the replication proteins in this model system were analyzed. Both SV40 T antigen as a DNA helicase and multisubunit human single-stranded DNA binding protein (HSSB) (also called RP-A) were required for the initial step of DNA synthesis. Furthermore, it has been shown that T antigen plays an essential role in the initiation of DNA replication from the ARS region in this system. The digestion of negatively supercoiled DNA with the single-strand-specific nuclease P1 revealed that regions containing A, B, and C domains of ARS1 can be unwound under the conditions used for DNA replication. Footprinting with KMnO4 indicated that T antigen interacted with the unwound B domain where initiation of DNA replication mainly occurred. When circular DNAs of different negative-superhelical densities were replicated in the absence of DNA gyrase, short fragments were synthesized from the ARS region in proportion to its density and they were elongated by addition of HeLa topoisomerase I, which inhibits the initiation of DNA replication in this system.(ABSTRACT TRUNCATED AT 250 WORDS)