gebhart/patrepeval huggingface dataset:
Error-locating codes--A new concept in error control (1963)

A new coding technique is proposed lying midway between error-detection and error-correction coding. The block of received digits is regarded as subdivided into mutually exclusive sub-blocks. Errors occurring within particular sub-blocks are detected at the receiver and, in addition, the receiver is able to determine, by using the code redundancy, which particular sub-blocks contain errors. Such {\em error-locating} codes permit the location of digit errors to within a sub-block of the received message block without, in general, permitting the precise determination of erroneous digit positions. Two families of such codes are described, both of them limited to locating a single erroneous sub-block. One family permits the detection of up to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t-1</tex> errors in any one sub-block of length <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</tex> . The second family locates up to two errors per sub-block, but is generally more efficient in its use of redundancy than the first family. Upper and lower bounds are given for the number of check digits required with any error-locating code. Codes meeting the lower bound exactly are termed {\em optimum} error-locating codes. All the codes of the second family, as well as some isolated examples of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t-1</tex> error-locating codes are optimum in this sense. The amount of redundancy required for such codes does not appear excessive and error location may provide an attractive alternative to conventional error detection in decision feedback communications.
Differences in inflammatory marker patterns for adult community‐acquired pneumonia patients induced by different pathogens (2017)

Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF-BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.
Long‐term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders (2006)

We sought to review the long-term tolerability of tetrabenazine (TBZ) and seek determinants of tolerability in the treatment of hyperkinetic movement disorders. A retrospective chart review was performed on patients treated with TBZ between 1997 and 2004. Efficacy of TBZ was assessed by a 1- to 5-point response scale (1 = marked reduction in abnormal movements, 5 = worsening). All adverse events (AEs) were captured according to their relationship with study drug. A total of 448 patients (42% male) were treated for a variety of hyperkinesias, including tardive dyskinesia (n = 149), dystonia (n = 132), chorea (n = 98), tics (n = 92), and myoclonus (n = 19). The mean age at onset of the movement disorder was 43.0 +/- 24.2 years, with TBZ starting at a mean age of 50.0 +/- 22.3 years. Patients remained on treatment for a mean of 2.3 +/- 3.4 years. An efficacy response rating of 1 or 2 was sustained in the majority of patients between the first and last visit. Common AEs included drowsiness (25.0%), Parkinsonism (15.4%), depression (7.6%), and akathisia (7.6%). Comparison of log-likelihood ratios revealed that age was a reliable predictor of Parkinsonism (P < 0.0001). TBZ is a safe and effective drug for the long-term treatment of hyperkinetic movement disorders.
Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen. (1992)

Laminin and type IV collagen are two major basement membrane glycoproteins. In previous studies it has been shown that nonenzymatic glucosylation induces structural alterations of these macromolecules and also reduces their ability to self-associate. In the present study, endothelial cells were tested for their ability to adhere and spread on nonenzymatically glucosylated laminin and type IV collagen. Adhesion and spreading were reduced when glucosylated macromolecules were used as substrates. Glucosylation-induced changes in adhesion and spreading may be an important initial event signaling other phenotypic modifications of cells in the microvasculature and may be a crucial factor in order to understand the pathogenesis of diabetic microangiopathy at the molecular level.
Inactivation of Visna Virus and Other Enveloped Viruses by Free Fatty Acids and Monoglycerides (1994)

Human milk was found to become antiviral during storage at 4 degrees C because of the release of fatty acids by lipolysis. The stored milk caused more than a 10,000-fold inactivation of visna virus during incubation at 37 degrees C for 30 minutes. Medium-chain saturated and long-chain unsaturated fatty acids inactivated visna virus and other enveloped viruses causing more than a 3000-fold to 10,000-fold reduction in virus titer. 1-Monoglycerides and ethers of medium-chain fatty acids were more antiviral than the corresponding free fatty acids. Antiviral fatty acids were found to affect the viral envelope, causing leakage and, at higher concentrations, a complete disintegration of the envelope and the viral particles. Lipids commonly found in natural products could possibly be used as antiviral agents against enveloped viruses.
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1 −/− mouse (2009)

Niemann-Pick type C disease is largely attributable to an inactivating mutation of NPC1 protein, which normally aids movement of unesterified cholesterol (C) from the endosomal/lysosomal (E/L) compartment to the cytosolic compartment of cells throughout the body. This defect results in activation of macrophages in many tissues, progressive liver disease, and neurodegeneration. In the npc1(-/-) mouse, a model of this disease, the whole-animal C pool expands from 2,082 to 4,925 mg/kg body weight (bw) and the hepatic C pool increases from 132 to 1,485 mg/kg bw between birth and 49 days of age. A single dose of 2-hydroxypropyl-beta-cyclodextrin (CYCLO) administered at 7 days of age immediately caused this sequestered C to flow from the lysosomes to the cytosolic pool in many organs, resulting in a marked increase in cholesteryl esters, suppression of C but not fatty acid synthesis, down-regulation of genes controlled by sterol regulatory element 2, and up-regulation of many liver X receptor target genes. There was also decreased expression of proinflammatory proteins in the liver and brain. In the liver, where the rate of C sequestration equaled 79 mg x d(-1) x kg(-1), treatment with CYCLO within 24 h increased C movement out of the E/L compartment from near 0 to 233 mg x d(-1) x kg(-1). By 49 days of age, this single injection of CYCLO resulted in a reduction in whole-body C burden of >900 mg/kg, marked improvement in liver function tests, much less neurodegeneration, and, ultimately, significant prolongation of life. These findings suggest that CYCLO acutely reverses the lysosomal transport defect seen in NPC disease.
Crystal forms of rifaximin and their effect on pharmaceutical properties (2008)

Five distinct crystal forms of rifaximin (α, β, γ, δ and ε) have been identified and characterised by X-ray powder diffraction, solid state 13C NMR, and HATR-IR spectroscopy. Changes in the crystal structure may produce differences of two to three orders of magnitude in the rate of intrinsic dissolution, solubility and bioavailability of rifaximin. Alteration of the pharmacokinetic parameters is of particular interest; the Cmax values of the crystal forms range from 1.1 to 1085.31 ng ml−1 and the AUC0-24 h values range from 10 to 4795 ng h ml−1. These findings are relevant to the therapeutic use of rifaximin.
Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials (2005)

Because of flawed methods and small clinical benefits, the scientific basis for recommendations of cholinesterase inhibitors for the treatment of Alzheimer's disease is questionable.
Human 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes (2002)

3'-Phosphoadenosine 5'-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5'-triphosphate (ATP) and inorganic sulfate (SO2-4) by two isoforms, PAPSS1 and PAPSS2. Rare mutations that inactivate PAPSS2 are associated with human spondyloepimetaphyseal dysplasia and murine brachymorphism. To determine whether more common genetic polymorphisms that do not completely inactivate the enzyme might be one factor responsible for individual differences in sulfate conjugation, we previously cloned the human PAPSS2 gene. In the present studies, we 'resequenced' all twelve PAPSS2 exons and splice junctions, as well as approximately 500 bp of the 5'-flanking region, using 90 Polymorphism Discovery Resource (PDR) DNA samples from the Coriell Cell Repository. Twenty-two single nucleotide polymorphisms (SNPs) were observed, including four nonsynonymous coding region SNPs (cSNPs) that altered the following amino acids: Glu10Lys, Met281Leu,Val291Met and Arg432Lys. We also observed four insertions/deletions, including one sample that was homozygous for an 81-bp deletion in the 5'-flanking region 286 bp upstream from the site of transcription initiation. Transient expression studies showed that two of the nonsynonymous cSNPS, those that resulted in Glu10Lys and Val291Met alterations in encoded amino acids, showed significant decreases in levels of PAPSS activity. In the case of Glu10Lys, decreased activity was paralleled by a decrease in immunoreactive protein, while the Val291Met allozyme displayed a significant decrease in affinity for both ATP and Na2SO4 when compared to 'wild-type' enzyme, but without a significant alteration in level of immunoreactive protein. It will now be possible to test the hypothesis that these common, functionally significant PAPSS2 genetic polymorphisms might contribute to variations in sulfate conjugation in vivo.
Mode coupling in nonuniform fibers: comparison between coupled-mode theory and finite-difference beam-propagation method simulations (1991)

Field evolution along longitudinally nonuniform finite-cladding fibers of circularly symmetric cross section is analyzed in terms of coupled modes. Local modes are used for abruptly tapered fibers, whereas linear-index fiber modes provide the expansion basis for Kerr-type nonlinear-index fibers. Convergence of the results suggests in both cases that only a finite number of bound modes is sufficient to describe the field adequately. A comparison with simulations given by a finite-difference beam-propagation method that was developed for circularly symmetric waveguides confirms the validity of this assumption.
An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. (1993)

Cystic fibrosis (CF) is an inherited disease of epithelial cell ion transport that is associated with pathology in multiple organ systems, including lung, pancreas, and liver. As treatment of the pulmonary manifestations of CF has improved, management of CF liver disease has become increasingly important in adult patients. This report describes an approach for treating CF liver disease by somatic gene transfer. In situ hybridization and immunocytochemistry analysis of rat liver sections indicated that the endogenous CFTR (cystic fibrosis transmembrane conductance regulator) gene is primarily expressed in the intrahepatic biliary epithelial cells. To specifically target recombinant genes to the biliary epithelium in vivo, recombinant adenoviruses expressing lacZ or human CFTR were infused retrograde into the biliary tract through the common bile duct. Conditions were established for achieving recombinant gene expression in virtually all cells of the intrahepatic bile ducts in vivo. Expression persisted in the smaller bile ducts for the duration of the experiment, which was 21 days. These studies suggest that it may be feasible to prevent CF liver disease by genetically reconstituting CFTR expression in the biliary tract, using an approach that is clinically feasible.
Cross-Coupling Reaction of Iodo-1,2,3-triazoles Catalyzed by Palladium (2005)

The Suzuki, Heck and Sonogashira reactions of 1,4-di­substituted 5-iodo-1,2,3-trizaoles were studied. A versatile method for regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazoles was developed.
High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains (2015)

Discovering new binding function via a combinatorial library in small protein scaffolds requires balance between appropriate mutations to introduce favorable intermolecular interactions while maintaining intramolecular integrity. Sitewise constraints exist in a non-spatial gradient from diverse to conserved in evolved antibody repertoires; yet non-antibody scaffolds generally do not implement this strategy in combinatorial libraries. Despite the fact that biased amino acid distributions, typically elevated in tyrosine, serine, and glycine, have gained wider use in synthetic scaffolds, these distributions are still predominantly applied uniformly to diversified sites. While select sites in fibronectin domains and DARPins have shown benefit from sitewise designs, they have not been deeply evaluated. Inspired by this disparity between diversity distributions in natural libraries and synthetic scaffold libraries, we hypothesized that binders resulting from discovery and evolution would exhibit a non-spatial, sitewise gradient of amino acid diversity. To identify sitewise diversities consistent with efficient evolution in the context of a hydrophilic fibronectin domain, >105 binders to six targets were evolved and sequenced. Evolutionarily favorable amino acid distributions at 25 sites reveal Shannon entropies (range: 0.3-3.9; median: 2.1; standard deviation: 1.1) supporting the diversity gradient hypothesis. Sitewise constraints in evolved sequences are consistent with complementarity, stability, and consensus biases. Implementation of sitewise constrained diversity enables direct selection of nanomolar affinity binders validating an efficient strategy to balance inter- and intra-molecular interaction demands at each site.
Design and implementation of a new computerized system for intraoperative cardiac mapping (1991)

A rapid, portable, yet inexpensive and expandable computer-based system utilizing current technology has been developed from experience in the operating room. An efficient operating system well suited for surgery is defined. New technology recording arrays fabricated from multielectrode flexible Kapton strips were developed and found to be easy to use and highly reliable. Novel arrays are created easily for research or special clinical applications. The system displays all incoming data in real time and transfers 16-s epochs to disk on command. After the user defines a beat for analysis, the computer determines the activation time for each channel, rejects unsatisfactory channels, and displays the results for review and modification before plotting the isochronal map on the monitor. The average time to recall data and produce a map is 16 s; if manual review of 120 channels is included, mapping time is less than 4 min. Clinical data recorded during surgery are discussed. The speed and operational ease demonstrated in the operating room make this computer/electrode system valuable both for surgery and for elucidating basic mechanisms of arrhythmias.
CMRadar: A Personal Assistant Agent for Calendar Management (2004)

One of the more compelling visions for agents re-search is the development of “personal assistant agents” that are tasked with making people and organizations more efficient by autonomously handling routine tasks
In vitro α-glucosidase inhibitory activity of phenolic constituents from aerial parts of Polygonum hyrcanicum (2012)

This study shows that P. hyrcanicum contains phenolic compounds with in vitro activity that can be useful in the context of preventing or mitigating cellular damages linked to diabetic conditions.
Stem cells with potential to generate insulin producing cells in man (2006)

Replacement of insulin-producing cells represents an almost ideal treatment for patients with diabetes mellitus type 1. Transplantation of pancreatic islets of Langerhans--although successful in experienced centres--is limited by the lack of donor organs. Generation of insulin-producing cells from stem cells represents an attractive alternative. Stem cells with the potential to differentiate into insulin-producing cells include embryonic stem cells (ESC) as well as adult stem cells from various tissues including the pancreas, liver, central nervous system, bone marrow and adipose tissue. The use of human ESC is hampered by ethical concerns and the inability to create patient specific ESC with therapeutic cloning. Among adult stem cells mesenchymal stem cells appear to have a particular developmental plasticity ex vivo that include their ability to adopt a pancreatic endocrine phenotype. The present review summarises the current knowledge on the development of insulin-producing cells from stem cells with special emphasis on human mesenchymal stem cells isolated from the pancreas and adipose tissue.
Melanin-concentrating hormone: unique peptide neuronal system in the rat brain and pituitary gland. (1986)

A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most prevalent in hypothalamus, mesencephalon, and pons-medulla regions. High concentrations of MCH-LI were measured in the hypothalamic medial forebrain bundle (MFB), posterior hypothalamic nucleus, and nucleus of the diagonal band. Reversed-phase high-performance liquid chromatography of MFB extracts from rat brain indicate that MCH-like peptide from the rat has a different retention time than that of the salmon MCH. An osmotic stimulus (2% NaCl as drinking water for 120 hr) caused a marked increase in MCH-LI concentrations in the lateral hypothalamus and neurointermediate lobe. The present studies establish the presence of MCH-like peptide in the rat brain. The MCH-LI neuronal system is well situated to coordinate complex functions such as regulation of water intake.
Dynamic plan migration for continuous queries over data streams (2004)

Dynamic plan migration is concerned with the on-the-fly transition from one continuous query plan to a semantically equivalent yet more efficient plan. Migration is important for stream monitoring systems where long-running queries may have to withstand fluctuations in stream workloads and data characteristics. Existing migration methods generally adopt a pause-drain-resume strategy that pauses the processing of new data, purges all old data in the existing plan, until finally the new plan can be plugged into the system. However, these existing strategies do not address the problem of migrating query plans that contain stateful operators, such as joins. We now develop solutions for online plan migration for continuous stateful plans. In particular, in this paper, we propose two alternative strategies, called the moving state strategy and the parallel track strategy, one exploiting reusability and the second employs parallelism to seamlessly migrate between continuous join plans without affecting the results of the query. We develop cost models for both migration strategies to analytically compare them. We embed these migration strategies into the CAPE [7], a prototype system of a stream query engine, and conduct a comparative experimental study to evaluate these two strategies for window-based join plans. Our experimental results illustrate that the two strategies can vary significantly in terms of output rates and intermediate storage spaces given distinct system configurations and stream workloads.
Antisense RNA Directed Against the 3′ Noncoding Region Prevents Dormant mRNA Activation in Mouse Oocytes (1988)

Primary mouse oocytes contain untranslated stable messenger RNA for tissue plasminogen activator (t-PA). During meiotic maturation, this maternal mRNA undergoes a 3'-polyadenylation, is translated, and is degraded. Injections of maturing oocytes with different antisense RNA's complementary to both coding and noncoding portions of t-PA mRNA all selectively blocked t-PA synthesis. RNA blot analysis of t-PA mRNA in injected, matured oocytes suggested a cleavage of the RNA.RNA hybrid region, yielding a stable 5' portion, and an unstable 3' portion. In primary oocytes, the 3' noncoding region was susceptible to cleavage, while the other portions of the mRNA were blocked from hybrid formation until maturation occurred. Injection of antisense RNA complementary to 103 nucleotides of its extreme 3' untranslated region was sufficient to prevent the polyadenylation, translational activation, and destabilization of t-PA mRNA. These results demonstrate a critical role for the 3' noncoding region of a dormant mRNA in its translational recruitment during meiotic maturation of mouse oocytes.
The Use of Ultrasound as an Enhancer for Transcutaneous Drug Delivery: Phonophoresis (1995)

Phonophoresis is the use of ultrasound (US) to enhance the delivery of topically applied drugs. The purposes of this article are (1) to review the basic principles of transcutaneous drug delivery, (2) to summarize the functional anatomy of the skin pertinent to phonophoresis, (3) to outline the physiological principles of US as an enhancer of topically applied drugs, (4) to review the literature on the efficacy of phonophoresis, (5) to discuss the relevance of US as an enhancer of topical drugs in the practice of physical therapy, and (6) to outline areas of needed research. Seventy-five percent of the studies reviewed reported positive effects of US on local subcutaneous drug diffusion, but some systemic effects were reported. This research review indicates that to maximize the clinical effectiveness of phonophoresis: (1) the topical drug (both the drug and the carrying agent) should transmit US; (2) the skin should be pretreated with US, heating, moistening, or shaving; (3) the patient needs to be positioned to maximize circulation during treatment; (4) a dressing that seals the area and prevents the escape of moisture should be applied after treatment; (5) an intensity of 1.5 W/cm2 should be used to capture both the thermal and nonthermal effects of the US; and (6) low-intensity US (0.5 W/cm2) should be used when treating open wounds or acute injuries. Research is needed to clarify what parameters of US will most efficiently facilitate topical drug diffusion, how often and for what duration US should be used to maximize local absorption of drugs, and which topical drugs can most effectively be used for phonophoresis.
Power auctions and network constraints (2002)

The merit order dispatch of generating units in a competitive power pool or power exchange can be considered as an auction. The use of a nondiscriminating auction that pays all winning bidders at a uniform price is consistent with the incentives for cost-revealing bids by market participants. This paper examines whether the nondiscriminating feature of an auction is possible when transmission constraints are considered under a framework of location dependent nodal spot pricing. The paper illustrates arbitrage opportunities that can result in strategic behavior by bidders under such a system.