gebhart/patrepeval huggingface dataset:
Visual Poetics: Art and the Word (2003)

Miami Art Museum, April 25 - November 16, 2003 There is an interesting poetic speculation that is a 'cumulative project' of the species, comparable to animal husbandry. (1) If you want to witness the sharp visual turn this human-language-project has taken in modernism, see the exhibition Visual Poetics: Art and the Word, on view at the Miami Art Museum through November 16. It consists of more than 50 works by 34 international artists who have set image and word on a collision course. The products are expansive and varied but the show cohesively focuses on avant-garde strategies of visual poetics and concrete poetry. Most work chronologically spans the post-World War II period up to the present, but stops short of broaching the digital domain. Even so, this excellent exhibition offers a surprisingly relevant set of models for current and future permutations of the human language project. [ILLUSTRATION OMITTED] Curator Cheryl Hartup organized the show using three categories: politics, poetics, and the formal. The categories function well as an organizing principle and hold up to scrutiny even if we regard the p in purely as continuing the alliterative play of letters. Actually, the playfulness of linguistic form and meaning underpins and animates works in any category and drives a multilogue of intentions and formal experimentation that defy easy classification. Still, there are distinctive eruptions here of cultural politics in such series as Glenn Ligon's Untitled (the Blackness Cannot be Separated From Me But Often I Can Stand Outside It). Quotations from black writers are stenciled large and bold and become progressively smudged, transposing their oral force into a somewhat blurred visual realm. Even one of the most formal works by Carl Andre (from 1956) evokes politics and power in the repetition of the phrase, Conquest Display, as a modular element in the rhythmic pattern-images of a typewriter. Poetics is aptly discussed by Hartup as an intervention of language into desire, memory and psychological formations. Rivane Neuenschwander's video, Love Lettering, displays words from e-mail messages attached to the tails of goldfish. Here the power of words and messages to somehow arrive at their destination seems to dissolve literally in the watery bowl of video. However fluid the boundaries between the thematic categories, message, and display, the exhibition clearly establishes a point of reference for experimental, avant-garde approaches to image and text through the symbolist poem, Un Coup de des by Stephane Mallarme. The themes, visual strategies, and impulse to use chance as a generator of form are spread throughout the exhibition both implicitly and explicitly. …
Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate (2014)

Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of the gene encoding mitochondrial cholesterol delivery protein (StarD1). Forty-eight hours after infection of the hepatocytes with recombinant StarD1 adenovirus, a water-soluble oxysterol product was isolated and purified by chemical extraction and reverse-phase HPLC. Tandem mass spectrometry analysis identified the oxysterol as 5-cholesten-3β, 25-diol, disulfate (25HCDS), and confirmed the structure by comparing with a chemically synthesized compound. Administration of 25HCDS to human THP-1-derived macrophages or HepG2 cells significantly inhibited cholesterol synthesis and markedly decreased lipid levels in vivo in NAFLD mouse models. RT-PCR showed that 25HCDS significantly decreased SREBP-1/2 activities by suppressing expression of their responding genes, including ACC, FAS, and HMG-CoA reductase. Analysis of lipid profiles in the liver tissues showed that administration of 25HCDS significantly decreased cholesterol, free fatty acids, and triglycerides by 30, 25, and 20%, respectively. The results suggest that 25HCDS inhibits lipid biosynthesis via blocking SREBP signaling. We conclude that 25HCDS is a potent regulator of lipid metabolism and propose its biosynthetic pathway.
Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network (2009)

Our results demonstrate that mechanistically distinct pathways operate to regulate apoptosis in mammalian cells under basal (physiological) versus stress-induced conditions. We also describe a novel apoptotic network which governs the basal survival of cancer cells. Such information is crucial for understanding normal cellular turnover during mammalian development and subsequently throughout life. This information also opens new avenues for therapeutic intervention in human proliferative disease states including cancer.
Identification of Essential Genes in the Human Fungal Pathogen Aspergillus fumigatus by Transposon Mutagenesis (2003)

ABSTRACT The opportunistic pathogen Aspergillus fumigatus is the most frequent cause of deadly airborne fungal infections in developed countries. In order to identify novel antifungal-drug targets, we investigated the genome of A. fumigatus for genes that are necessary for efficient fungal growth. An artificial A. fumigatus diploid strain with one copy of an engineered impala160 transposon from Fusarium oxysporum integrated into its genome was used to generate a library of diploid strains by random in vivo transposon mutagenesis. Among 2,386 heterozygous diploid strains screened by parasexual genetics, 1.2% had a copy of the transposable element integrated into a locus essential for A. fumigatus growth. Comparison of genomic sequences flanking impala160 in these mutants with that of the genome of A. fumigatus allowed the characterization of 20 previously uncharacterized A. fumigatus genes. Among these, homologues of genes essential for Saccharomyces cerevisiae growth have been identified, as well as genes that do not have homologues in other fungal species. These results confirm that heterologous transposition using the transposable element impala is a powerful tool for functional genomics in ascomycota, and they pave the way for defining the complete set of essential genes in A. fumigatus , the first step toward target-based development of new antifungal drugs.
Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology. (2011)

To demonstrate the presence or absence of myoepithelial cells, a panel-based approach of 2 or more markers is recommended. Markers that most effectively combine sensitivity, specificity, and ease of interpretation include smooth muscle myosin heavy chains, calponin, p75, p63, P-cadherin, basal cytokeratins, maspin, and CD10. These markers, however, display varying cross-reactivity patterns and variably reduced expression in the myoepithelial cells bordering in situ carcinomas. The choice of a myoepithelial marker should be dependent on a combination of factors, including published evidence on its diagnostic utility, its availability, performance characteristics that have been achieved in a given laboratory, and the specific diagnostic scenario. When its use is deemed necessary, immunohistochemistry for myoepithelial cells in breast pathology is most effective when conceptualized as supplemental, rather than central to routine morphologic interpretation.
THE NEW GENOME VARIANTS IN RUSSIAN CHILDREN WITH GENETICALLY DETERMINED CARDIOMYOPATHIES REVEALED WITH MASSIVE PARALLEL SEQUENCING (2017)

Background: Cardiomyopathies in children are serious, continuously progressing myocardium diseases which are characterized by a variety of the causes, symptoms, implications, and high lethality. More than 400 genes that can cause hereditary heart and vessels diseases are described in scientific literature. The application of a high-performance method of massive parallel sequencing allows to conduct the investigation of genome extended targeted areas revealing the variants and analyzing them (bioinformatics) for pathogenicity.Aims: Identification of a genetic etiology of hereditary cardiomyopathies development in children’s population of the Russian Federation.Materials and methods: The research included 103 patients with various phenotypes of cardiomyopathies aged from 3 months up to 17 years 9 months who at the moment of examination were observed in the cardiology department and the department of recovery treatment with cardiovascular diseases in the NMRCCH. All patients were performed massive parallel sequencing analyzing the targeted areas of 404 genes which mutations lead to the development of heart and vessels hereditary diseases.Results: The diagnostic algorithm based on the method of a massive parallel sequencing was developed. 176 258 minor options were identified in the explored target areas of genome of 103 patients. An average number of the revealed nucleotide replacements different from the reference sequence was 1711. We observed that about 40% of all variants founded by our means were found in MYH7, MYBPC3, TTN, MYH6, SCN5A, DSC2 and TPM1 genes. Bioinformatics analysis allowed revealing 68 novel genome variants associated with cardiomyopathy development. The reliable association of carriage of pathogenic option in MYBPC3 gene with development of hypertrophic cardiomyopathy in the Russian children was found.Conclusions: The application of the offered algorithm allowed establishing laboratory diagnoses to 99 (96.1%) patients out from 103 investigated subjects including the syndromal and non-syndromal forms of heart and vessels hereditary diseases which showed a cardiomyopathy phenotype.
Programming by demonstration using version space algebra DRAFT to appear in Machine Learning (2001)

Programming by demonstration enables users to easily personalize their applications, automating repetitive tasks simply by executing a few examples. We formalize programming by demonstration as a machine learning problem: given the changes in the application state that result from the user's demonstrated actions, learn the general program that maps from one application state to the next. We present a methodology for learning in this space of complex functions. First we extend version spaces to learn arbitrary functions, not just concepts. Then we intro- duce the version space algebra, a method for composing simpler version spaces to construct more complex spaces. Finally, we apply our version space algebra to the text-editing domain and describe an implemented system called SMARTedit that learns repetitive text-editing procedures by example. We evaluate our approach by measuring the number of examples required for the system to learn a procedure that works on the remainder of examples, and by an informal user study measuring the eort users spend using our system versus performing the task by hand. The results show that SMARTedit is capable of generalizing correctly from as few as one or two examples, and that users generally save a significant amount of eort when
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases (2007)

Fibroproliferative diseases, including the pulmonary fibroses, systemic sclerosis, liver cirrhosis, cardiovascular disease, progressive kidney disease, and macular degeneration, are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Fibrotic tissue remodeling can also influence cancer metastasis and accelerate chronic graft rejection in transplant recipients. Nevertheless, despite its enormous impact on human health, there are currently no approved treatments that directly target the mechanism(s) of fibrosis. The primary goals of this Review series on fibrotic diseases are to discuss some of the major fibroproliferative diseases and to identify the common and unique mechanisms of fibrogenesis that might be exploited in the development of effective antifibrotic therapies.
BASE SEQUENCE DETERMINATION IN NUCLEIC ACIDS WITH THE ELECTRON MICROSCOPE, III. CHEMISTRY AND MICROSCOPY OF GUANINE-LABELED DNA (1965)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Intramolecular O-Glycoside Bond Formation (2000)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular O-Glycoside Bond FormationKarl-Heinz Jung, Matthias Müller, and Richard R. SchmidtView Author Information Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany Cite this: Chem. Rev. 2000, 100, 12, 4423–4442Publication Date (Web):November 21, 2000Publication History Received14 August 2000Published online21 November 2000Published inissue 1 December 2000https://pubs.acs.org/doi/10.1021/cr990307khttps://doi.org/10.1021/cr990307kresearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views2974Altmetric-Citations168LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbohydrates,Post-translational modification,Precursors,Reaction products,Stereoselectivity Get e-Alerts
Dinuclear platinum complexes containing aryl-isoquinoline and oxadiazole-thiol with an efficiency of over 8.8%: in-depth investigation of the relationship between their molecular structure and near-infrared electroluminescent properties in PLEDs (2016)

Two novel dinuclear platinum complexes of (2niq)<sub>2</sub>Pt<sub>2</sub>(μ-C<sub>8</sub>PhOXT)<sub>2</sub> and (piq)<sub>2</sub>Pt<sub>2</sub>(μ-PhOXT)<sub>2</sub> were synthesized and characterized.
Role of B cell antigen processing and presentation in the humoral immune response (1991)

In the 25 years since it was first indicated that lymphocyte subpopulations must interact during the generation of a humoral immune response, there has been an explosion of data on the molecular mechanism of this interaction. It has been demonstrated that T cells recognize a processed antigen fragment presented by a major histocompatibility complex molecule on the surface of an antigen-presenting cell. The minimal peptides required for T cell recognition of several proteins have been determined, the molecular genetics of many of the cell surface molecules involved have been defined, and the three-dimensional structure of the T cell receptor and the major histocompatibility antigens have been deduced. Several cell types have been found to act as antigen-presenting cells, although the roles of these populations in vivo remain unclear. However, it is clear that there must be a physical interaction between a B cell and a T cell before the B cell can respond to a T-dependent antigen. This interaction requires processing and presentation of the antigen by the B cell. Therefore this review focuses on antigen processing and presentation by resting B cells, one of the key steps in initiation of a humoral immune response.
A postgermination developmental arrest checkpoint is mediated by abscisic acid and requires the ABI5 transcription factor in Arabidopsis (2001)

Seed dormancy is a trait of considerable adaptive significance because it maximizes seedling survival by preventing premature germination under unfavorable conditions. Understanding how seeds break dormancy and initiate growth is also of great agricultural and biotechnological interest. Abscisic acid (ABA) plays primary regulatory roles in the initiation and maintenance of seed dormancy. Here we report that the basic leucine zipper transcription factor ABI5 confers an enhanced response to exogenous ABA during germination, and seedling establishment, as well as subsequent vegetative growth. These responses correlate with total ABI5 levels. We show that ABI5 expression defines a narrow developmental window following germination, during which plants monitor the environmental osmotic status before initiating vegetative growth. ABI5 is necessary to maintain germinated embryos in a quiescent state thereby protecting plants from drought. As expected for a key player in ABA-triggered processes, ABI5 protein accumulation, phosphorylation, stability, and activity are highly regulated by ABA during germination and early seedling growth.
Distributed control in the electricity infrastructure (2005)

Different driving forces push the electricity production towards decentralization. As a result, the current electricity infrastructure is expected to evolve into a network of networks, in which all system parts communicate with each other and influence each other. Multiagent systems and electronic markets form an appropriate technology needed for control and coordination tasks in the future electricity network. We present the PowerMatcher, a market-based control concept for supply and demand matching (SDM) in electricity networks. In a simulation study we show the ability of this approach to raise the simultaneousness of electricity production and consumption within (local) control clusters. This control concept can be applied in different business cases like reduction of imbalance costs in commercial portfolios or virtual power plant operation of distributed generators. Two PowerMatcher-based field test configurations are described, one currently in operation, one currently under construction
Detecting future social unrest in unprocessed Twitter data: &#x201C;Emerging phenomena and big data&#x201D; (2013)

We have implemented a social media data mining system capable of forecasting events related to Latin American social unrest. Our method directly extracts a small number of tweets from publicly-available data on twitter.com, condenses similar tweets into coherent forecasts, and assembles a detailed and easily-interpretable audit trail which allows end users to quickly collect information about an upcoming event. Our system functions by continually applying multiple textual and geographic filters to a large volume of data streaming from twitter.com via the public API as well as a commercial data feed. To be specific, we search the entirety of twitter.com for a few carefully chosen keywords, search within those tweets for mentions of future dates, filter again using various logistic regression classifiers, and finally assign a location to an event by geocoding retweeters. Geocoding is done using our previously-developed in-house geocoding service which, at the time of this writing, can infer the home location for over 62M twitter.com users [1]. Additionally, we identify demographics likely interested in an upcoming event by searching retweeter's recent posts for demographic-specific keywords.
Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis. (1975)

Lesional epidermis of psoriasis has a probable reduction in the cyclic AMP/cyclic GMP ratio. This altered ratio may in part be responsible for the characteristic glycogen storage, rapid cell proliferation, and reduced differentiation in lesional epidermis. The concentrations of prostaglandins E2 and F2alpha, free arachidonic acid, and 12L-hydroxy-5,8,10,14-eicosatetrawnoic acid in specimens of uninvolved and involved epidermis of psoriasis were measured with deuterium-labeled carriers and multiple ion analysis. Snap frozen specimens contained: 1.4 +/- 0.4 mug/g (wet weight) of arachidonic acid in uninvolved in contrast to 36.3 +/- 16.7 mug/g in involved epidermis (P = 0.015); less than 0.05 +/- 0.01 mug/g of hydroxyeicosatetraenoic acid in uninvolved in contrast to 4.1 +/- 1.9 mug/g in involved epidermis (P = 0.015); 23.6 +/- 5.0 ng/g of prostaglandin E2 in uninvolved in contrast to 33.1 +/- 5.7 ng/g in involved epidermis (P less than 0.01); and 21.0 +/- 4.4 ng/g of prostaglandin F2alpha in uninvolved in contrast to 39.0 +/- 5.9 ng/g in involved epidermis (P less than 0.01). The arachidonic acid and hydroxyeicosatetraenoic acid levels in involved epidermis were strongly correlated (r = 0.97). The increased levels of arachidonic acid and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid in involved epidermis may have diagnostic and pathophysiological importance.
Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells. (1991)

Exposure to ethanol for several days increases the number and function of dihydropyridine-sensitive Ca2+ channels in excitable tissues. In the neural cell line PC12, this process is blocked by inhibitors of protein kinase C (PKC), suggesting that PKC mediates ethanol-induced increases in Ca2+ channels. We report that treatment with 25-200 mM ethanol for 2-8 days increased PKC activity in PC12 cells and NG108-15 neuroblastoma-glioma cells. Detailed studies in PC12 cells showed that ethanol also increased phorbol ester binding and immunoreactivity to PKC delta and PKC epsilon. These changes were associated with increased PKC-mediated phosphorylation. Ethanol did not activate the enzyme directly, nor did ethanol increase levels of diacylglycerol. Ethanol-induced increases in PKC levels may promote up-regulation of Ca2+ channels, and may also regulate the expression and function of other proteins involved in cellular adaptation to ethanol.
Novel Negative Regulatory Element in the Platelet-derived Growth Factor B Chain Promoter That Mediates ERK-dependent Transcriptional Repression (2000)

Platelet-derived growth factor (PDGF), which consists of an A and/or B chain, stimulates migration and proliferation in vascular smooth muscle cells as well as a large number of other cell types. Investigations over recent years have defined roles for several positive regulatory transcription factors in the PDGF-B promoter. However, little is known about the transcriptional mechanisms that negatively regulate this gene. Here, we used transient transfection and 5' deletion analysis to define a specific region in the PDGF-B promoter-mediating repression in vascular smooth muscle cells. Gel retardation assays revealed this region is bound by nuclear protein(s) in a specific manner. Supershift assays excluded the direct association of Sp1, Sp3, and Egr-1. Mutation of the negative regulatory element no longer supported nucleoprotein complex formation and, when introduced into the PDGF-B promoter, rescued the promoter from repression. Promoter activity was also restored by transfection of oligonucleotide decoys bearing the repressor binding site. The MEK1/2 inhibitor, PD98059, and a dominant negative construct generating inactive ERK1 increased reporter expression driven by the PDGF-B promoter. In contrast, the MEK inhibitor had no effect on the activity of the mutant PDGF-B promoter. These effects were cell type-specific, since neither suppression of the PDGF-B promoter nor nucleoprotein complex formation was observed in vascular endothelial cells. These findings define a distinct negative regulatory element in the PDGF-B promoter that interacts with nuclear protein(s) and inhibits PDGF-B promoter-dependent gene expression in an ERK-dependent manner.