gebhart/patrepeval huggingface dataset:
Controlled Delivery of Peptides and Proteins (2006)

The final aim/target of Pharmaceutical Sciences is to design successful dosage forms for effective therapy, considering individual patient needs and compliance. Development of new drug entities, particularly using peptides and proteins, is growing in importance and attracting increased interest, as they are specifically effective at a comparably low dose. These very potent and specific peptides and proteins can now be produced in large quantities due to increased knowledge and advancements in biotechnological and pharmaceutical applications. A number of peptide and protein products are now available on the market, and numerous studies investigating them have been published in the literature. Although many peptide/protein like products are generally designed for parenteral administration, some other noninvasive routes have also been used. For example, desmopressin is delivered nasally and deoxyribonuclease by inhalation. Although peptides and proteins are generally orally inactive, cyclosporine is an exception. In order to design and develop long-acting, more effective peptide/protein drugs, the controlled release mechanisms and effective parameters need to be understood and clarified. Therefore, we review herein various peptide/protein delivery systems, including biodegradable and nondegradable microspheres, microcapsules, nanocapsules, injectable implants, diffusion-controlled hydrogels and other hydrophilic systems, microemulsions and multiple emulsions, and the use of iontophoresis or electroporation, and discuss the results of recent researches.
Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer. (1991)

The relationship between interphase cytogenetics and tumor grade, stage, and proliferative activity was investigated in 27 transitional cell carcinomas of the urinary bladder. Using fluorescence in situ hybridization with chromosome-specific DNA probes, the copy number of pericentromeric sequences on chromosomes 7, 9, and 11 was detected within interphase nuclei in touch preparations from tumor biopsies. Monosomy of chromosome 9 was detected in 9 of 22 cases (41%), while tetrasomy for chromosomes 7 and 11 was detected in 10 of 26 (38%) and 6 of 23 (26%) cases, respectively. Copy number of chromosome 7 was the most highly correlated with increasing tumor grade (r2 = 0.616, P less than 0.001, Spearman rank correlation) or increasing pathological stage (r2 = 0.356, P less than 0.002). Copy number for chromosome 9 did not correlate with either grade or stage (P greater than 0.05). Tumor labeling index (LI) was determined after in vitro 5-bromodeoxyuridine incorporation, while proliferating cell nuclear antigen LI was determined immunohistochemically. Increasing LI by either method correlated with increasing copy number for all three chromosomes tested (r2 = 0.473, P less than 0.002 for 7; r2 = 0.384, P less than 0.01 for 11; and r2 = 0.316, P less than 0.05 for 9). Since high tumor grade, stage, and LI are all indicative of more aggressive tumor behavior and worse prognosis, these findings suggest that polysomy, especially for chromosome 7, may be highly predictive for bladder tumor aggressiveness.
Solid-state structures of rosette and crinkled tape motifs derived from the cyanuric acid melamine lattice (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-state structures of rosette and crinkled tape motifs derived from the cyanuric acid melamine latticeJonathan A. Zerkowski, Christopher T. Seto, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1992, 114, 13, 5473–5475Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ja00039a096https://doi.org/10.1021/ja00039a096research-articleACS PublicationsRequest reuse permissionsArticle Views1340Altmetric-Citations274LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Thiamine Inactivation by the Fresh-Fish or Chastek-Paralysis Factor1 (1943)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThiamine Inactivation by the Fresh-Fish or Chastek-Paralysis Factor1Robert R. Sealock, Arthur H. Livermore, and Charles A. EvansCite this: J. Am. Chem. Soc. 1943, 65, 5, 935–940Publication Date (Print):May 1, 1943Publication History Published online1 May 2002Published inissue 1 May 1943https://pubs.acs.org/doi/10.1021/ja01245a046https://doi.org/10.1021/ja01245a046research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of Uniform Protein−Polymer Conjugates (2005)

We have developed a novel technique to synthesize near-uniform protein-polymer conjugates by initiating atom transfer radical polymerization of monomethoxy poly(ethylene glycol)-methacrylate from 2-bromoisobutyramide derivatives of chymotrypsin (a protein-initiator). Polymerization initiated from the monosubstituted protein-initiator resulted in the conjugate containing a single, near-monodisperse polymer chain per protein molecule with polydispersity index 1.05. Increasing the number of conjugated 2-bromoisobutyramide initiators per molecule of protein increased the molecular weights and polydispersity indices of the final protein-polymer conjugates. The generic nature of this technique was demonstrated by initiating polymerization of nonionic, cationic, and anionic monomers from the protein-initiator. Protein-polymer conjugates synthesized by this novel technique retained 50-86% of the original enzyme activity. The technique described herein should be useful in synthesizing well-defined protein-polymer conjugates exhibiting a wide range of physical and chemical properties.
Receiving and transmitting light-like radio waves: Antenna effect in arrays of aligned carbon nanotubes (2004)

We present optical measurements of random arrays of aligned carbon nanotubes, and show that the response is consistent with conventional radio antenna theory. We first demonstrate the polarization effect, the suppression of the reflected signal when the electric field of the incoming radiation is polarized perpendicular to the nanotube axis. Next, we observe the interference colors of the reflected light from an array, and show that they result from the length matching antenna effect. This antenna effect could be used in a variety of optoelectronic devices, including THz and IR detectors.
Hydrogen Production with a Microbial Biocathode (2007)

This paper, for the first time, describes the development of a microbial biocathode for hydrogen production that is based on a naturally selected mixed culture of electrochemically active micro-organisms. This is achieved through a three-phase biocathode startup procedure that effectively turned an acetate- and hydrogen-oxidizing bioanode into a hydrogen-producing biocathode by reversing the polarity of the electrode. The microbial biocathode that was obtained in this way had a current density of about -1.2 A/Nm2 at a potential of -0.7 V. This was 3.6 times higher than that of a control electrode (-0.3 A/m2). Furthermore, the microbial biocathode produced about 0.63 m3 H2/m3 cathode liquid volume/day at a cathodic hydrogen efficiency of 49% during hydrogen yield tests, whereas the control electrode produced 0.08 m3 H2/m3 cathode liquid volume/day at a cathodic hydrogen efficiency of 25%. The effluent of the biocathode chamber could be used to inoculate another electrochemical cell that subsequently also developed an identical hydrogen-producing biocathode (-1.1 A/m2 at a potential of -0.7 V). Scanning electron micrographs of both microbial biocathodes showed a well-developed biofilm on the electrode surface.
An obstetric scoring system: its development and application in obstetric management. (1993)

It was possible to develop a risk scoring system with a predictive accuracy higher than any previously reported statistically derived score. Summation of the logistic coefficients provides a score that by comparison with a chosen threshold identifies a high-risk pregnancy. In this way, despite the complexity of statistical analysis, all clinicians can quickly apply this scoring system.
Combinative interactions of a human immunodeficiency virus (HIV) Tat antagonist with HIV reverse transcriptase inhibitors and an HIV protease inhibitor (1994)

Combinations of the human immunodeficiency virus (HIV) Tat protein antagonist Ro 24-7429 with either the HIV protease inhibitor Ro 31-8959 or the HIV reverse transcriptase inhibitors AZT (3'-azido-3'-deoxythymidine), ddC (2',3'-dideoxycytidine), ddI (2',3'-dideoxyinosine), and nevirapine were synergistic or additive in reducing HIV type 1 p24 antigen production in CEM cells or inhibiting HIV type 1-induced syncytium formation in HT4-6C cells.
Digital Pictures: Representation, Compression, and Standards (1995)

From the Publisher:
Since the first edition of Digital Pictures in 1988, several international standards have been established for digitization of bilevel images, color pictures, videoconferencing, and television. In Digital Pictures, Second Edition, Arun N. Netravali and Barry G. Haskell address these modern innovations and review recently established international standards for digital imagery. They discuss the current state of the art, including JBIG, JPEG, H.261, CCIR601, CCIR723, MPEG1, MPEG2, and HDTV technology. Their book also thoroughly covers the fundamentals and practical algorithms of image digitization and compression. The text's new chapters feature examples and questions designed to stimulate greater understanding of the topics which describe: basic aspects of the JBIG algorithm and different JPEG operating modes; some methodologies used for video codecs operating at subprimary bit-rates; a generic coding standard that can be used in many digital video implementations; and the main characteristics of HDTV; its current state in Europe, Japan, and the United States; and expected future developments. Digital Pictures, Second Edition, concludes with a review of source encoding limitations and brief descriptions of two approaches to model-based coding of video. Its comprehensive coverage of progress in the field will be valuable for communication systems engineers and researchers working in the areas of image compression, communication, and processing. Advanced undergraduate and graduate students will find it an essential text on image digitization, processing, coding, and compression.
First percutaneous transcatheter aortic valve‐in‐valve implant with three year follow‐up (2008)

The CoreValve prosthesis has maintained proper function up to 3 years, with no structural deterioration or migration. Treating mixed aortic valve disease with predominant AR is feasible. The concept as well as durability of the first PHV-in-PHV has also been demonstrated.
Cell Membranes Suspended Across Nanoaperture Arrays (2005)

We present a method for spreading large (>100 microm(2)) cell membrane fragments across nanoapertures in planar supports. Electron-beam and focused-ion-beam lithography were used to fabricate arrays of 50-600 nm diameter holes in free-standing silicon nitride (SiN) solid films 100-500 nm thick. By pressing adhering live cells onto the nanostructured SiN surface and then removing them, planar cell membrane sheets (CMSs) were transferred in a well-defined orientation onto the SiN support. We demonstrate the accessibility to both extracellular and intracellular surfaces of CMSs by targeting membrane constituents side-specifically with fluorescent markers. Our approach is of interest for studying ligand-receptor interactions using optical, electrical, and scanning probe techniques at the single-molecule level.
Synthesis of the cis and trans isomers of 4-Chloro-L-proline, 4-Bromo-L-proline, and 4-Amino-L-proline (1967)

cis- and trans-4-Chloro- and 4-bromo-L-prolines have been synthesized stereospecifically, the key step being SN2 displacement of a free or substituted 4-hydroxyl group in suitably protected 4-hydroxy-L- prolines. Similar displacements with azide ion followed by reduction provide convenient routes to cis- and trans- 4-amino-L-proline. A less satisfactory pathway to cis-4-aminoproline is reduction of a 4- oximinoproline derivative. In the course of the syntheses, which involve a variety of protecting groups, 45 new L-proline derivatives have been prepared. Unexpected side reactions were the formation of cis-4-hydroxyprolinamide by the action of ammonia on trans-4- bromoproline, and the reduction by sodium borohydride of N- benzyloxycarbonyl-4-oximinoproline methyl ester to N-benzyloxycar- bonyl-4-oximinoprolinol.
siaD PCR ELISA for confirmation and identification of serogroup Y and W135 meningococcal infections (1998)

Non-culture diagnosis and serogroup determination of meningococcal infection is important in contact management where vaccination may be possible. A serogroup B and C PCR ELISA assay for the non-culture diagnosis and serogroup determination has proved invaluable for enhanced epidemiological surveillance and contact management. A polymerase chain reaction assay, based on a restriction fragment length polymorphism in the meningococcal serogroup Y and W135 sialyltransferase (siaD) gene, was developed to enhance the range of non-culture diagnosis of meningococcal infection from clinical samples. The PCR assay was adapted to an ELISA format incorporating hybridisation with serogroup-specific Y and W135 oligonucleotide probes. The serogroup-specific W135 and Y PCR ELISA is a useful addition to currently available serogroup B and C assay for non-culture diagnosis of meningococcal infection and outbreak investigation.
Implementing a blood management protocol during the entire perioperative period allows a reduction in transfusion rate in major orthopedic surgery: a before–after study (2016)

Introduction of a PBM protocol, using EPO, FCM, and tranexamic acid, reduces the number of perioperative transfusions and of patients with a Hb level of less than 10 g/dL at discharge.
Polymerization of vegetable oils and their uses in printing inks (1994)

Abstract Ink vehicles were prepared by the polymerization of vegetable oils. By controlling the polymerization conditions, the desired viscosity, color and molecular weight could be achieved for a variety of vegetable oils with a broad range of iodine values and fatty acid compositions. The effect of temperature and catalyst on polymerization rates were evaluated, and polymerization rate constants were calculated. Of the oils tested, the polymerization rate constant of safflower oil was the highest, followed by soybean, sunflower, cottonseed and canola oils in decreasing order. Use of a catalyst shortened the heating time by about 25–50% or lowered the polymerization temperature requirement by 25–30°C.
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy (2011)

The anti-CD20 mAb rituximab is central to the treatment of B-cell malignancies, but resistance remains a significant problem. We recently reported that resistance could be explained, in part, by internalization of rituximab (type I anti-CD20) from the surface of certain B-cell malignancies, thus limiting engagement of natural effectors and increasing mAb consumption. Internalization of rituximab was most evident in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), but the extent of internalization was heterogeneous within each disease. Here, we show that the inhibitory FcγRIIb on target B cells promotes this process and is largely responsible for the observed heterogeneity across a range of B-cell malignancies. Internalization correlated strongly with FcγRIIb expression on normal and malignant B cells, and resulted in reduced macrophage phagocytosis of mAb-coated targets. Furthermore, transfection of FcγRIIb into FcγRIIb negative Ramos cells increased internalization of rituximab in a dose-dependent manner. Target-cell FcγRIIb promoted rituximab internalization in a cis fashion and was independent of FcγRIIb on neighboring cells. It became phosphorylated and internalized along with CD20:anti-CD20 complexes before lysosomal degradation. In MCL patients, high FcγRIIb expression predicted less durable responses after rituximab-containing regimens. Therefore, target-cell FcγRIIb provides a potential biomarker of response to type I anti-CD20 mAb.
CMOS compatible transformer power combiner (2006)

A new approach for power combining several low-voltage CMOS amplifiers using a new on-chip transformer architecture is presented. The transformer utilises lateral coupling and thus the layout only requires one relatively thick metal layer. Full-wave electromagnetic simulation confirms the operation and low insertion loss of the transformer.
User interfaces for volumetric displays (2001)

Volumetric displays, which enable true 3D image visualization, hold the promise of enhancing rendered 3D graphics' sense of realism by providing all the depth cues humans require. Although still in the prototype stage, 3D volumetric displays present unique user interface challenges. The authors use physical mock-ups to explore solutions to interaction styles for 3D volumetric displays.
Droplet Collision in Liquid Propellant Combustion (1997)

Abstract : Droplet collision is of relevance to spray combustion, intimately influencing the spray characteristics in the dense spray region. The present study aims to gain fundamental understanding on the mechanisms governing the observed phenomena of permanent coalescence, bouncing, and separation upon droplet collision. Specific issues of interest include the extent of droplet deformation, the dynamics of the inter-droplet flow, the relative importance of the gas resistance force as compared to the collision inertia, and the relevant rheological properties of the gases and liquids. Extensive experiments have been performed for various liquids, environment gases, and system pressures. A unified concept has crystallized regarding the specific mechanisms and factors controlling the five distinct regimes of collision outcomes for both water and hydrocarbon droplets, namely (I) coalescence with slight deformation, (II) bouncing, (III) coalescence with substantial deformation, (IV) coalescence followed by separation for near head-on collisions, and (V) coalescence followed by separation for off-center collisions. A coalescence/separation criterion defining the transition between regimes (III) and (IV) for head-on collisions was also derived and found to agree well with the experimental data. jg p.2
MINIMALLY-INVASIVE DIRECT CARDIAC MASSAGE (1993)

Buckman, Robert Jr; Badellino, Michael; Mauro, Leann; Aldridge, Samuel; Milner, Richard; Mercer, David Author Information
Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies (2014)

Polyclonal γδ T cells can be activated and propagated with clinical-grade aAPCs and demonstrate broad antitumor activities, which will facilitate the implementation of γδ T-cell cancer immunotherapies in humans.
The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5′-end processing of S. cerevisiae box C/D snoRNAs (2003)

Small nucleolar RNAs (snoRNAs) play important roles in ribosomal RNA metabolism. In Saccharomyces cerevisiae, box C/D snoRNAs are synthesized from excised introns, polycistronic precursors, or independent transcription units. Previous studies have shown that only a few independently transcribed box C/D snoRNAs are processed at their 5' end. Here we describe 12 additional independently transcribed box C/D snoRNAs that undergo 5'-end processing. 5' Extensions found in the precursors of these snoRNAs contain cleavage sites for Rnt1p, the S. cerevisiae homolog of RNase III, and unprocessed precursors accumulate in vivo in the absence of Rnt1p. Rnt1p cleavage products were identified in vivo when the 5' --> 3' exonucleases Xrn1p and Rat1p are inactivated (xrn1delta rat1-1) and in vitro using model RNA substrates and recombinant Rnt1p. Some of these snoRNAs show increased levels of unprocessed precursors when the rnt1Delta deletion is combined to the xrn1delta rat1-1 mutation, suggesting that these exonucleases participate in the 5' processing or the degradation of the snoRNA precursors. Unprocessed precursors are not significantly destabilized in the absence of the trimethylguanosine capping enzyme Tgs1p, suggesting that a 5' monomethyl cap is sufficient to ensure stabilization of these precursors. These results demonstrate that the majority of independently transcribed box C/D snoRNAs from the yeast genome undergo 5'-end processing and that the Rnt1p endonuclease and the Xrn1p and Rat1p 5' --> 3'exonucleases have partially redundant functions in the 5'-end processing of these snoRNAs.
Selective hydrolysis of hardwood hemicellulose by acids (1978)

Low-level hydrolysis was investigated as a method of selectively recovering hemicellulose sugars from hardwood residue (southern red oak). Both strong and weak acids (sulfuric, sulfurous, and acetic) were used at various concentrations, seeking for an optimum processing condition. The spent residue was further hydrolyzed by Trichoderma viride enzime to evaluate the hemicellulose hydrolysis step as a pretreatment process in glucose production. This paper also discussed the process economics, projecting the laboratory data to a commercial-scale production of xylose from hardwood residue. A near quantitative recovery of hemicellulose sugar is achieved using either 0.1% or 0.2% H/sub 2/SO/sub 4/. The results from hydrolysis experiments using sulfur dioxide were included. The catalytic activity of acetic acid was far inferior to that of either sulfuric acid or sulfur dioxide. 9 figures, 3 tables.