gebhart/patrepeval huggingface dataset:
Recent Developments in the Synthesis of Supported Catalysts (2015)

ADVERTISEMENT RETURN TO ISSUEReviewNEXTRecent Developments in the Synthesis of Supported CatalystsPeter Munnik, Petra E. de Jongh, and Krijn P. de Jong*View Author Information Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 14, 6687–6718Publication Date (Web):June 19, 2015Publication History Received29 August 2014Published online19 June 2015Published inissue 22 July 2015https://doi.org/10.1021/cr500486uCopyright © 2015 American Chemical Society. This publication is licensed under these Terms of Use. Request reuse permissions This publication is Open Access under the license indicated. Learn MoreArticle Views66878Altmetric-Citations919LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (30 MB) Get e-AlertscloseSUBJECTS:Catalysts,Deposition,Metals,Nanoparticles,Precursors Get e-Alerts
Review of Recent Patents on Foldable Ventricular Assist Devices (2012)

Congestive heart failure accounts for a high morbidity worldwide. The only effective treatment for end-stage patients is heart transplantation or, in light of the shortage of suitable donors, an artificial heart or ventricular assist device (VAD). The newer-generation continuous-flow rotary VADs allow for a significant reduction in size and an improvement in reliability. However, the invasive implantation still limits this technology from being offered to critically ill patients. To benefit more heart failure patients, there is a need to develop a long-term VAD which can be implanted via minimally invasive procedure. Recently, expandable/deployable devices have been investigated as a potential solution. Such a device can be inserted percutaneously via the peripheral vessels in its collapsed form and operate in its expanded form at the desired location. This paper reviews significant patents on foldable VADs using mechanical and/or material means. Mechanically folded structures adapt joints and links to facilitate the folding process whilst utilization of elastic materials allows the structure to be bent or twisted without permanent deformation. Current and future developments of foldable VADs are discussed. Foldable pumps could generate less blood damage and mechanical wear as compared to current miniature percutaneous VADs. Therefore, foldable VADs have the potential for longer-term application and minimally invasive insertion, providing a promising solution for heart failure patients.
Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction (1997)

Focal cerebral infarction (stroke) due to unilateral occlusion of the middle cerebral artery in mature rats produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. We found that biweekly intracisternal injection of basic fibroblast growth factor (bFGF; 0.5 microg/injection), a potent neurotrophic polypeptide, markedly enhanced recovery of sensorimotor function of the contralateral limbs during the first month after stroke without apparent adverse side effects. Immunostaining for growth-associated protein 43 (GAP-43), a molecular marker of axonal sprouting, showed a selective increase in GAP-43 immunoreactivity in the intact sensorimotor cortex contralateral to cerebral infarcts following bFGF treatment. These results show that bFGF treatment can enhance functional recovery after stroke, and that the mechanism may include stimulation of neuronal sprouting in the intact brain.
New amorphous thin-film lithium electrolyte and rechargeable microbattery (2003)

Sputtering of Li/sub 3/PO/sub 4/ in pure N/sub 2/ results in the formation of an amorphous lithium electrolyte that is suitable in contact with lithium and has electrical properties that are suitable for application in a thin-film cell. Thin-film rechargeable lithium cells have been fabricated and characterized using this electrolyte between a lithium anode and an amorphous vanadium oxide cathode. The open circuit voltage of the cell is 3.6 to 3.7 V, and it has a capacity of 130 mu Ah/cm/sup 2/ when discharged to 1.5 V. The AC impedance of the cells measured at different stages of discharge indicate a significant decrease in internal resistance at about the midpoint of the discharge.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dynamic Behavior of Avian Influenza A Virus Neuraminidase Subtype H5N1 in Complex with Oseltamivir, Zanamivir, Peramivir, and Their Phosphonate Analogues (2009)

The outbreak of avian influenza A subtype H5N1 virus has raised a global concern for both animal as well as human health. Recently, drug resistance in H5N1 infections has been widely reported due to neuraminidase mutations. Consequently, the understanding of inhibitor-neuraminidase interactions at the molecular level represents the main goal of our study. Molecular dynamics simulations were carried out for the neuraminidase N1 in complex with six inhibitors--oseltamivir, zanamivir, peramivir, and their phosphonate analogues. Molecular dynamics trajectories were extensively analyzed in terms of important interactions between inhibitors and the enzyme target. Results show that open and closed forms (defined by the relative position of the flexible 150-loop) of neuraminidase N1 interchange during the course of 20 ns molecular dynamics simulation of the protein-inhibitor complexes. Reported free energies of closing indicate that the carboxylate inhibitors prefer the closed form more than their phosphonate analogues. This can be understood in view of the negative total charge (-1 e0) of the phosphonate inhibitors, which repels the Asp151 residue of the loop away from the inhibitor and drives the complex into the open form. Obtained results constitute new valuable information to assist further drug development of inhibitors against the H5N1 avian influenza A virus and could also inspire similar studies for other systems of the influenza family such as the 2009 influenza A (H1N1) virus.
Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells (1987)

Physicochemical properties of recombinant human erythropoietin were examined. This protein, produced in Chinese hamster ovary cells, showed a conformation apparently identical with the natural product isolated from human urine when examined by circular dichroism, UV absorbance, and fluorescence spectroscopy. Sedimentation equilibrium experiments showed the recombinant erythropoietin preparation to be essentially a single macromolecular component with a molecular weight of 30,400 and a carbohydrate content of 39%. The Stokes radius of recombinant erythropoietin was estimated to be 32 A from gel filtration, much larger than the 20-A radius calculated for a sphere of the observed molecular weight. This difference may be ascribed to the extensive glycosylation. The fluorescence and phosphorescence spectra showed that the luminescent tryptophan(s) is (are) solvent-exposed and can be quenched by I- and acrylamide but not by Cs+. On acid titration, the recombinant erythropoietin showed a conformational transition with a midpoint of pH 4.1. This suggests that the net charges on the protein moiety rather than on the whole molecule play a role in protein structure stability.
Photoresponse characteristics of thin-film nickel-nickel oxide-nickel tunneling junctions (1983)

Photoinduced tunneling currents in thin-film Ni-NiO-Ni tunneling junctions were measured as a function of photon energy over the range 2.0 eV <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\leq hf \leq 2.7</tex> eV. The photoresponse mechanism was found to be consistent with a photon assisted tunneling mechanism. Inelastic electron-electron collisions were found to strongly influence the photoassisted tunneling currents.
The synthesis and stability of oligodeoxyribonucleotides containing the deoxyadenosine mimic 1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4- carboxamide (1997)

Oligodeoxyribonucleotides containing the nucleoside analog 1-(2'-deoxy-beta-D-ribofuranosyl) imidazole-4-carboxamide (1) were synthesized by solid phase phosphoramidite technology. Nucleoside 1, which contains a reactive exocyclic amide moiety, was incorporated into synthetic oligodeoxyribonucleotides with the use of a benzoyl protecting group. The corresponding oligodeoxyribonucleotides with dI or dA in the same position in the sequence were synthesized for UV comparison of helix-coil transitions. The thermal melting studies indicate that 1, which could conceptually adopt either a dA- or a dI-like hydrogen bond configuration, pairs with significantly higher affinity to T than to dC. Nucleoside 1 further resembles dA in the relative order of its base pairing preferences (T >dG >dA >dC), but may be less discriminating than dA in its bias for base pairing with T over dG.
Effect of higher pasteurization temperatures, and longer holding times at 72°C, on the inactivation ofMycobacterium paratuberculosisin milk (1999)

Raw cow's milk spiked with 10(6) cfu ml-1 of Mycobacterium paratuberculosis was subjected to heat treatments of 72, 75, 78, 80, 85 or 90 degrees C for 15 s, and 72 degrees C for 20 and 25 s, using laboratory pasteurizing units. Three bovine strains of Myco. paratuberculosis were studied (NCTC 8578, B2 and DVL 943). Each strain was subjected to all the heat treatments indicated on three separate occasions. Although each of the heat treatments achieved a substantial (5-6 log10) reduction in numbers of viable Myco. paratuberculosis, small numbers of the organism (4-16 cfu 10 ml-1) survived in a proportion of the milk samples at each of the higher temperatures investigated, right up to 90 degrees C for 15 s. A longer holding time of 25 s at 72 degrees C was found to be more effective at inactivating Myco. paratuberculosis. Only one of the three strains studied, B2, yielded small numbers of survivors after heating at 72 degrees C for 20 s, but it was completely inactivated by extending the holding time at 72 degrees C by a further 5 s to 25 s. It was concluded that a longer holding time is more likely to achieve the complete inactivation of Myco. paratuberculosis in milk than a higher pasteurization temperature.
Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells (2005)

Phosphodiesterase Type 5 is the main factor regulating cyclic guanosine monophosphate hydrolysis and downstream signaling in human PASMCs. The antiproliferative effects of this signaling pathway may be significant in the chronic treatment of pulmonary hypertension with PDE5 inhibitors such as sildenafil.
Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases. (1993)

A rapid method for the identification of known proteins separated by two-dimensional gel electrophoresis is described in which molecular masses of peptide fragments are used to search a protein sequence database. The peptides are generated by in situ reduction, alkylation, and tryptic digestion of proteins electroblotted from two-dimensional gels. Masses are determined at the subpicomole level by matrix-assisted laser desorption/ionization mass spectrometry of the unfractionated digest. A computer program has been developed that searches the protein sequence database for multiple peptides of individual proteins that match the measured masses. To ensure that the most recent database updates are included, a theoretical digest of the entire database is generated each time the program is executed. This method facilitates simultaneous processing of a large number of two-dimensional gel spots. The method was applied to a two-dimensional gel of a crude Escherichia coli extract that was electroblotted onto poly(vinylidene difluoride) membrane. Ten randomly chosen spots were analyzed. With as few as three peptide masses, each protein was uniquely identified from over 91,000 protein sequences. All identifications were verified by concurrent N-terminal sequencing of identical spots from a second blot. One of the spots contained an N-terminally blocked protein that required enzymatic cleavage, peptide separation, and Edman degradation for confirmation of its identity.
Ion-translocating Properties of Calcifiable Proteolipids (1988)

De novo formation of calcium hydroxyapatite in biological systems occurs on membrane surfaces through specific interactions of Ca, Pi, phospholipids, calcifiable proteolipids, and ion flux to and from the nucleating site. This paper reports an in vitro model demonstrating an ion transport function for calcifiable proteolipid. Bacterionema matruchotii proteolipid was incubated with a radiolabeled H+-channel inhibitor, 14C-dicyclohexyl-carbodiimide, and binding characterized by displacement studies with DCCD or ethyldimethylaminopropylcarbodiimide. A carboxyl binding site was suggested by displacement of DCCD by the nucleophile, glycine ethyl ester. The displacement studies indicated that proteolipid bound DCCD via carboxyl group interaction in a hydrophobic region of the protein. SDS-polyacrylamide gel electrophoresis showed that all label was associated with a single band of 8500 Mr. No non-specific binding of 14C-DCCD to phospholipids occurred, since all bound label was associated with protein following Sephadex LH-20 chromatography of crude proteolipid. Phospholipid liposomes were prepared containing bacteriorhodopsin and proteolipid or proteolipid-14C-DCCD, via cholate dialysis. Transmembrane pH changes established by the bacteriorhodopsin H+ pump were measured in the presence and absence of added proteolipid. Proteolipid had an effect similar to those of uncouplers such as tetraphenylboron. Both the rate and extent of proton translocation increased following addition of proteolipid to BR-liposomes. 14C-DCCD abolished the proteolipid-augmented ion transport. When tetraphenylboron was used to abolish the transmembrane electrical potential, calcifiable proteolipid did not augment proton transport.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators. (1995)

An early event associated with neutrophil-dependent tissue damage involves the adhesion of neutrophils to the vascular endothelium and the subsequent release of oxygen-derived free radicals and granule constituents. Elevations in intracellular cAMP are known to inhibit free radical release but not lysosomal enzyme release. The role of cAMP in FMLP-induced neutrophil adhesion was examined in this study by using an in vitro model of neutrophil-endothelial cell adhesion. FMLP stimulated a time- and concentration-dependent increase in human neutrophil adhesion to HUVEC. FMLP-mediated adhesion was inhibited by a diverse group of cAMP modulators: forskolin, isoproterenol, phosphodiesterase IV inhibitors (rolipram and Ro 20-1724), but not phosphodiesterase III inhibitors (milrinone and bemoradan). Endogenous adenosine has previously been shown to mediate FMLP-induced increases in cAMP enhanced in the presence of Ro 20-1724. In this study, adenosine deaminase prevented the inhibitory effects observed with rolipram and Ro 20-1724, implicating endogenous adenosine as a co-modulator of inhibition. FMLP stimulated neutrophil shape change and the surface expression of the beta 2 integrins CD11b/CD18 and CD11a/CD18. Both these responses were inhibited by rolipram but not bemoradan. With the use of 4,4'-diisothiocyanostilbene-2,2'disulfonic acid, we showed that mobilization of the intracellular pool of CD11b/CD18 paralleled adhesion. We conclude that neutrophil-endothelial cell adhesion is attenuated by elevating neutrophil intracellular cAMP and that inhibition of neutrophil CD11b/CD18 surface expression by cAMP accounts for this observed inhibition of adhesion.
DNA origami-based nanoribbons: assembly, length distribution, and twist (2011)

A variety of polymerization methods for the assembly of elongated nanoribbons from rectangular DNA origami structures are investigated. The most efficient method utilizes single-stranded DNA oligonucleotides to bridge an intermolecular scaffold seam between origami monomers. This approach allows the fabrication of origami ribbons with lengths of several micrometers, which can be used for long-range ordered arrangement of proteins. It is quantitatively shown that the length distribution of origami ribbons obtained with this technique follows the theoretical prediction for a simple linear polymerization reaction. The design of flat single layer origami structures with constant crossover spacing inevitably results in local underwinding of the DNA helix, which leads to a global twist of the origami structures that also translates to the nanoribbons.
Reaction between Itaconic Acid and Vinyl Acetate, and Synthesis of Polyvinyl Itaconate (1963)

イタコン酸の反応の一つとして,イタコン酸と酢酸ビニルとの反応によって,ビニルエステルを得る可能性を検討するために両者の反応を行なった。さらにポリビニルアルコールと無水イタコン酸との反応によってポリビニルイタコネートを得た。反応方法はイタコン酸と酢酸ビニルとの反応では,Adelmanのビニル交換反応の方法に従って,イタコン酸を酢酸ビニル中に加え,硫酸水銀(II)を触媒にして常温放置または沸点で熱して行なった。ポリビニルイタコネートは無水イタコン酸とポバールを酢酸中(酢酸ナトリウムを加え)または,ジメチルホルムアミド中でピリジンを触媒として熱して得られた。結果はイタコン酸と酢酸ビニルの反応では酢酸ビニル,アセトアルデヒド,酢酸等の低留分を留去した後,減圧蒸留すると,エチリデンジアセテートに相当する留分と主留分I(bp82～85℃/13mmHg)と後留分II(bp88～95℃/13mmHg)が得られた。Iは元素分析,赤外線分析その他の結果からエチリデンジエステル型の反応生成物(A)であることがわかった。後留分中には無水シトラコン酸およびイタコン酸ジビニルエステルが混在していることがわかったが,沸点近接のため単離できなかった。シトラコン酸の場合も酢酸ビニルとの反応で同様の生成物が得られた。また,ポリピニルイタコネートは熱水に不溶の弾力ある透明なフィルムを作る固体樹脂で一般の溶剤にとけ難い。ナトリウム塩は水溶性で高分子電解質の一種と考えられる。
Near-surface resistivity contrast mapping with a capacitive sensor array and an inductive source (2011)

Electromagnetic survey methodology is adapted to use the electric component to directly detect buried resistors and map resistivity contrasts in the near surface. System implementations do not require ground contact because they use capacitive electric-field sensors and an inductive source and may be operated at walking pace. This study outlined theoretical basis, computational modeling, and verification for the methodology. The systems are designed to operate at low enough frequency that any responses are at the resistive limit; as such, the electric fields they measure are insensitive to horizontal layering and absolute conductivity. A surface integral equation algorithm is used to model regular discrete objects in a half-space. Anomalies are controlled by geometry and lateral resistivity contrast rather than by absolute resistivity values. A prototype electrode array system called CARIS 1 reliably detects resistive objects submerged in a saltwater tank, and the measured responses are consistent with numerical modeling. These results provided the basis for further development of the CARIS II system with flexible geometry that is adaptable to detect resistive or conductive targets in any background environment. CARIS is designed to be useful where conventional electromagnetics, ground-penetrating radar, and conventional resistivity face difficulties or fail, and it has easily detected a range of buried targets in the near surface. However, it is quite sensitive to disturbed ground and surface undulation and inhomogeneity.
Development of an Integrated Reservoir Model for a Naturally Fractured Volcanic Reservoir in China (2000)

Abstract This paper presents the development of an integrated, multi-discipline reservoir model for dynamic flow simulation and performance prediction of a geologically complex naturally fractured volcanic reservoir in the Shang 741 Block of the Shengli field in China. The reservoir contains a series of vertically separated fractured volcanic reservoirs with different size and fracture intensity. A static geological model of the reservoir is developed based on integration of principles of lithological depositional setting, petrophysics, fracture analysis and stochastic fracture network modeling using FormationMicroImager (FMI) log data, a 3D seismic survey and advanced seismic interpretations. A simulation model for the reservoir is constructed in a step-wise fashion by properly combining multi-disciplinary data sources, anchored with sound principles of reservoir engineering and geoscience. Information from single well and interference pressure transient data as well as water cut information from wells help assign key dynamic controls on the reservoir. These include effective fracture permeability magnitude, quantification of fracture-matrix interaction, reservoir unit compartmentalization, and flow transmissibility characteristics of conductive faults. As a result of synergy and multiple iterations among various disciplines and utilization of integrated project teams, a reliable history matched dynamic reservoir model capable of future performance prediction for optimum asset management is constructed. Among many scenarios investigated, it is found that implementation of water injection schemes would provide optimum recovery mechanism for the Shang 741 Block field.
A Natural Language Approach to Content-Based Video Indexing and Retrieval for Interactive E-Learning (2004)

As a powerful and expressive nontextual media that can capture and present information, instructional videos are extensively used in e-learning (Web-based distance learning). Since each video may cover many subjects, it is critical for an e-learning environment to have content-based video searching capabilities to meet diverse individual learning needs. In this paper, we present an interactive multimedia-based e-learning environment that enables users to interact with it to obtain knowledge in the form of logically segmented video clips. We propose a natural language approach to content-based video indexing and retrieval to identify appropriate video clips that can address users' needs. The method integrates natural language processing, named entity extraction, frame-based indexing, and information retrieval techniques to explore knowledge-on-demand in a video-based interactive e-learning environment. A preliminary evaluation shows that precision and recall of this approach are better than those of the traditional keyword based approach.