gebhart/patrepeval huggingface dataset:
Plane-wave decomposition of seismograms (1982)

Abstract A point-source seismic recording can be decomposed into a set of plane-wave seismograms for arbitrary angles of incidence. Such plane-wave seismograms possess an inherently simple structure that make them amenable to existing inversion methods such as predictive deconvolution. Implementation of plane-wave decomposition (PWD) takes place in the frequency-wavenumber domain under the assumption of radial symmetry. This version of PWD is equivalent to slant stacking if allowance is made for the customary use of linear recording arrays on the surface of a three-dimensional medium. An imaging principle embodying both kinematic as well as dynamic characteristics allows us to perform time migration of the plane-wave seismograms. The imaging procedure is implementable as a two-dimensional filter whose independent variables are traveltime and angle of incidence.
Autologous Fibrin for Blepharoplasty Incisions (1989)

To the Editor. — Blepharoplasty is being performed with increasing frequency. A variety of materials and techniques, including absorbable skin sutures, removable nonabsorbable subcuticular pullout sutures, and cyanoacrylate adhesives, are being used to close these delicate incisions. The goal is to obtain the best-quality scar with the fewest complications (suture cysts and granulomas). The current report describes use of autologous fibrin glue for blepharoplasty closure. Report of a Case.— A healthy 29-year-old white woman had dermatochalasis. Blood replacement was necessary for her liposculpture procedure, and a single unit was deposited in the blood bank. Using a cryoprecipitate technique, the fibrinogen was isolated and preserved (Corus Laboratories, Costa Mesa, Calif). An upper and lower lid blepharoplasty was completed using only a few key sutures in the lateral aspect of the incisions. The solution of fibrinogen was mixed with an equal volume of bovine thrombin and delivered to the wound surface via
Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal (2004)

Unesterified cholesterol is an essential structural component of the plasma membrane of every cell. During evolution, this membrane came to play an additional, highly specialized role in the central nervous system (CNS) as the major architectural component of compact myelin. As a consequence, in the human the mean concentration of unesterified cholesterol in the CNS is higher than in any other tissue (approximately 23 mg/g). Furthermore, even though the CNS accounts for only 2.1% of body weight, it contains 23% of the sterol present in the whole body pool. In all animals, most growth and differentiation of the CNS occurs in the first few weeks or years after birth, and the cholesterol required for this growth apparently comes exclusively from de novo synthesis. Currently, there is no evidence for the net transfer of sterol from the blood into the brain or spinal cord. In adults, the rate of synthesis exceeds the need for new structural sterol, so that net movement of cholesterol out of the CNS must take place. At least two pathways are used for this excretory process, one of which involves the formation of 24(S)-hydroxycholesterol. Whether or not changes in the plasma cholesterol concentration alter sterol metabolism in the CNS or whether such changes affect cognitive function in the brain or the incidence of dementia remain uncertain at this time.
Rapid iIdentification of proteins by peptide-inass fingerprinting (1993)

Developments in ‘soft’ ionisation techniques have revolutionized mass-spectro- metric approaches for the analysis of protein structure. For more than a decade, such techniques have been used, in conjunction with digestion by specific pro- teases, to produce accurate peptide molecular weight ‘lingerprints’ of proteins. These linger-prints have com- monly been used to screen known proteins, in order to detect errors of translation, to characterize post-trans- lational mod&cations and to assign disulphide bonds. However, the extent to which peptide-mass information can be used alone to identify unknown sample proteins, independent of other analytical methods such as protein sequence analysis, has remained largely unexplored.
ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure) (2001)

"Heart failure (HF) is a major public health problem in the United States. Nearly 5 million patients in this country have HF, and nearly 500,000 patients are diagnosed with HF for the first time each year. The disorder is the underlying reason for 12 to 15 million office visits and 6.5 million hospital days each year (1). During the last 10 years, the annual number of hospitalizations has increased from approximately 550,000 to nearly 900,000 for HF as a primary diagnosis and from 1.7 to 2.6 million for HF as a primary or secondary diagnosis (2). Nearly 300,000 patients die of HF as a primary or contributory cause each year, and the number of deaths has increased steadily despite advances in treatment. HF is primarily a disease of the elderly (3). Approximately 6% to 10% of people older than 65 years have HF (4), and approximately 80% of patients hospitalized with HF are more than 65 years old (2). HF is the most common Medicare diagnosis-related group, and more Medicare dollars are spent for the diagnosis and treatment of HF than for any other diagnosis (5). The total inpatient and outpatient costs for HF in 1991 were approximately $38.1 billion, which was approximately 5.4% of the healthcare budget that year (1). In the United States, approximately $500 million annually is spent on drugs for the treatment of HF. The American College of Cardiology (ACC) and the American Heart Association (AHA) first published guidelines for the evaluation and management of HF in 1995 (6). Since that time, a great deal of progress has been made in the development of both pharmacological and nonpharmacological approaches to treatment for this common, costly, disabling, and generally fatal disorder. For this reason, the 2 organizations believed that the time was right to reassess and update these guidelines, fully recognizing that the optimal therapy of HF remains a work in progress and that future guidelines will supersede these."
Symmetrical, four-directional, poly(ether-amide) cascade polymers (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleSymmetrical, four-directional, poly(ether-amide) cascade polymersGeorge R. Newkome and Xiaofeng LinCite this: Macromolecules 1991, 24, 6, 1443–1444Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ma00006a042https://doi.org/10.1021/ma00006a042research-articleACS PublicationsRequest reuse permissionsArticle Views1168Altmetric-Citations167LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Actin and Phosphoinositide Binding by the ActA Protein of the Bacterial Pathogen Listeria monocytogenes (1999)

The surface protein ActA of the pathogenic bacterium Listeria monocytogenes induces actin-driven movement of bacteria in the cytoplasm of infected host cells and serves as a model for actin-based motility in general. We generated and purified soluble recombinant fragments of ActA and assessed their ability to interact with the acidic phospholipids phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, both implicated in the regulation of actin polymerization. Purified ActA consisted of biologically active, elongated molecules with an alpha-helix and beta-sheet content of 11 and 32%, respectively. In the presence of either phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate, but not phosphatidylcholine, ActA molecules underwent a structural change that raised the alpha-helix content to 19% and lowered the beta-sheet content to 27%. Co-sedimentation experiments with phosphatidylcholine vesicles containing different acidic phospholipids demonstrated that ActA binds preferentially to D-3 phosphoinositides. The D-3 phosphoinositide binding activity was mapped to a small subregion in the N-terminal domain of ActA. This subregion comprised 19 amino acids and showed homology to cecropins. In addition, we found that amino acids 33 to 74 of ActA mediated actin binding by the whole, folded ActA molecule. These findings shed new light on ActA function.
2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors:  Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity (2004)

Following the identification through virtual screening of 4-(2,4-dimethyl-thiazol-5-yl)pyrimidin-2-ylamines as moderately potent inhibitors of cyclin-dependent kinase-2 (CDK2), a CDK inhibitor analogue program was initiated. The first aims were to optimize potency and to evaluate the cellular mode of action of lead candidate molecules. Here the synthetic chemistry, the structure-guided design approach, and the structure-activity relationships (SARs) that led to the discovery of 2-anilino-4-(thiazol-5-yl)pyrimidine ATP-antagonistic CDK2 inhibitors, many with very low nM K(i)s against CDK2, are reported. Furthermore, X-ray crystal structures of four representative analogues from our chemical series in complex with CDK2 are presented, and these structures are used to rationalize the observed biochemical SARs. Finally results are reported that show, using the most potent CDK2 inhibitor compound from the current series, that the observed antiproliferative and proapoptotic effects are consistent with cellular CDK2 and CDK9 inhibition.
Integrating perceptual and cognitive modeling for adaptive and intelligent human-computer interaction (2002)

This paper describes technology and tools for intelligent human-computer interaction (IHCI) in which human cognitive, perceptual, motor and affective factors are modeled and used to adapt the H-C interface. IHCI emphasizes that human behavior encompasses both apparent human behavior and the hidden mental state behind behavioral performance. IHCI expands on the interpretation of human activities, known as W4 (what, where, when, who). While W4 only addresses the apparent perceptual aspect of human behavior the W5+ technology for IHCI described in this paper addresses also the why and how questions, whose solution requires recognizing specific cognitive states. IHCI integrates parsing and interpretation of nonverbal information with a computational cognitive model of the user which, in turn, feeds into processes that adapt the interface to enhance operator performance and provide for rational decision-making. The technology proposed is based on a general four-stage interactive framework, which moves from parsing the raw sensory-motor input, to interpreting the user's motions and emotions, to building an understanding of the user's current cognitive state. It then diagnoses various problems in the situation and adapts the interface appropriately. The interactive component of the system improves processing at each stage. Examples of perceptual, behavioral, and cognitive tools are described throughout the paper Adaptive and intelligent HCI are important for novel applications of computing, including ubiquitous and human-centered computing.
Identification and characterization of alternative exon usage linked glioblastoma multiforme survival (2012)

Abstract Background Alternative exon usage (AEU) is an important component of gene regulation. Exon expression platforms allow the detection of associations between AEU and phenotypes such as cancer. Numerous studies have identified associations between gene expression and the brain cancer glioblastoma multiforme (GBM). The few consistent gene expression biomarkers of GBM that have been reported may be due to the limited consideration of AEU and the analytical approaches used. The objectives of this study were to develop a model that accounts for the variations in expression present between the exons within a gene and to identify AEU biomarkers of GBM survival. Methods The expression of exons corresponding to 25,403 genes was related to the survival of 250 individuals diagnosed with GBM in a training data set. Genes exhibiting AEU in the training data set were confirmed in an independent validation data set of 78 patients. A hierarchical mixed model that allows the consideration of covariation between exons within a gene and of the effect of the epidemiological characteristics of the patients was developed to identify associations between exon expression and patient survival. This general model describes all three possible scenarios: multi-exon genes with and without AEU, and single-exon genes. Results AEU associated with GBM survival was identified on 2477 genes (P-value &lt; 5.0E-04 or FDR-adjusted P-value &lt; 0.05). G-protein coupled receptor 98 ( Gpr98 ) and epidermal growth factor ( Egf ) were among the genes exhibiting AEU with 30 and 9 exons associated with GBM survival, respectively. Pathways enriched among the AEU genes included focal adhesion, ECM-receptor interaction, ABC transporters and pathways in cancer. In addition, 24 multi-exon genes without AEU and 8 single-exon genes were associated with GBM survival (FDR-adjusted P-value &lt; 0.05). Conclusions The inferred patterns of AEU were consistent with in silico AS models. The hierarchical model used offered a flexible and simple way to interpret and identify associations between survival that accommodates multi-exon genes with or without AEU and single exon genes. Our results indicate that differential expression of AEU could be used as biomarker for GBM and potentially other cancers.
The bromide content of underground waters. Part II. Observations on the chlorination of water containing free ammonia and naturally occurring bromide (1946)

Abstract In Part I of this paper reference was made to the occurrence of up to 2·20 p.p.m. of bromine, combined as bromide, in some underground water supplies of Southern England. The effect of traces of bromide in tests for free chlorine is now discussed. Bacteriological experiments also indicate that when waters containing free ammonia are being chlorinated, the presence of small amounts of bromide leads to a considerable acceleration of the rate of sterilisation: it appears that this effect is marked with 1 p.p.m. of combined bromine but as little as 0·25 p.p.m. may be significant under some conditions. The experiments were mainly confined to the case where the organic content of the water was very small, but this frequently applies in underground supplies.
Crystal Structure of the CUB1-EGF-CUB2 Domain of Human MASP-1/3 and Identification of Its Interaction Sites with Mannan-binding Lectin and Ficolins (2008)

MASP-1 and MASP-3 are homologous proteases arising from alternative splicing of the MASP1/3 gene. They include an identical CUB(1)-EGF-CUB(2)-CCP(1)-CCP(2) module array prolonged by different serine protease domains at the C-terminal end. The x-ray structure of the CUB(1)-EGF-CUB(2) domain of human MASP-1/3, responsible for interaction of MASP-1 and -3 with their partner proteins mannan-binding lectin (MBL) and ficolins, was solved to a resolution of 2.3A(.) The structure shows a head-to-tail homodimer mainly stabilized by hydrophobic interactions between the CUB(1) module of one monomer and the epidermal growth factor (EGF) module of its counterpart. A Ca(2+) ion bound primarily to both EGF modules stabilizes the intra- and inter-monomer CUB(1)-EGF interfaces. Additional Ca(2+) ions are bound to each CUB(1) and CUB(2) module through six ligands contributed by Glu(49), Asp(57), Asp(102), and Ser(104) (CUB(1)) and their counterparts Glu(216), Asp(226), Asp(263), and Ser(265) (CUB(2)), plus one and two water molecules, respectively. To identify the residues involved in interaction of MASP-1 and -3 with MBL and L- and H-ficolins, 27 point mutants of human MASP-3 were generated, and their binding properties were analyzed using surface plasmon resonance spectroscopy. These mutations map two homologous binding sites contributed by modules CUB(1) and CUB(2), located in close vicinity of their Ca(2+)-binding sites and stabilized by the Ca(2+) ion. This information allows us to propose a model of the MBL-MASP-1/3 interaction, involving a major electrostatic interaction between two acidic Ca(2+) ligands of MASP-1/3 and a conserved lysine of MBL. Based on these and other data, a schematic model of a MBL.MASP complex is proposed.
Analysis of monoclonal antibodies reactive with meconium‐ and amniotic fluid‐derived mucin (1994)

The present study was undertaken to determine whether monoclonal antibodies (moABs TKH-2, MA54, MA61, B72.3, and CC49) directed toward O-linked mucin-type glycoprotein detect the NeuAc alpha 2-6GalNAc (sialyl Tn) epitope in meconium- and amniotic fluid-derived mucin. Fetal colonic mucosal cells express the sialyl Tn antigen, particularly in goblet cell mucin. The reactivities of these moABs with a perchloric acid extract of meconium (meconium extract) and different native and neuraminidase treated glycoproteins were examined by solid-phase enzyme-linked immunosorbent assay (ELISA). All the moABs react with the meconium supernatant and meconium extract. The reactivities of TKH-2, MA54, and MA61 are neuraminidase sensitive, and the reactivity of TKH-2 with meconium extract was specifically inhibited by ovine submaxillary mucin (OSM). A NeuAc alpha 2-6GalNAc epitope is the characteristic component in meconium. Mucin released from the fetal respiratory tract could, in part, provide an alternative source in the amniotic fluid. TKH-2 is the most sensitive antibody directed to sialyl Tn antigen in meconium supernatant. The likelihood of TKH-2 serving as the basis for a sensitive assay to detect sialyl Tn in meconium- and amniotic fluid-derived mucin is provided.
Metastability of Molecular Phases of Nitrogen: Implications to the Phase Diagram (2001)

Despite their simplicity, diatomic molecules of first row elements can exhibit very complex phase diagrams. Determination of the phase diagrams can be further complicated by the existence of hysteretic molecular phases that can be observed over large regions of coexistence. Here we present evidence for a previously unreported molecular phase of nitrogen existing at room temperature at least over the range of 33-74 GPa. Our measurements show that sample history may have a significant impact on the thermodynamic states accessed by the molecular nitrogen solid and, by extension, also on the established phase diagram.
Probiotics in the management of atopic eczema (2000)

The results provide the first clinical demonstration of specific probiotic strains modifying the changes related to allergic inflammation. The data further indicate that probiotics may counteract inflammatory responses beyond the intestinal milieu. The combined effects of these probiotic strains will guide infants through the weaning period, when sensitization to newly encountered antigens is initiated. The probiotic approach may thus offer a new direction in the search for future foods for allergy treatment and prevention strategies.
Circulating microRNA as a biomarker of human growth hormone administration to patients (2013)

Circulating microRNAs (miRNAs) in plasma are being studied for use as biomarkers of specific diseases and as markers of administration of pharmaceutical agents. Administration of recombinant human growth hormone (rhGH) is prohibited by sporting authorities, but it continues to be used by athletes attempting to gain an unfair advantage in athletic competition. Current methods for detection of rhGH use rely on immunoassay technology and are limited by a short time-frame in which detection of rhGH is possible. We hypothesized that administration of rhGH would alter expression of circulating miRNAs and that any changes could be detected. To identify potential miRNA targets, we utilized miRNA microarrays for screening. Confirmatory testing used real-time reverse-transcriptase (RT) quantitative PCR (qPCR) assays of selected miRNAs in 35 plasma samples obtained from (1) individuals with no known pituitary disorders, (2) patients with excess GH production, and (3) patients receiving therapeutic replacement doses of rhGH. We identified and confirmed four miRNAs that were differentially expressed in all individuals using therapeutic replacement doses of rhGH when compared to individuals with naturally high levels of GH and normal controls. This study further develops the hypothesis that circulating miRNAs may be used as biomarkers for detection of doping in sports.
Ionophore-Based Lithium Ion Film Optode Realizing Multiple Color Variations Utilizing Digital Color Analysis (2002)

Digital color analysis (DCA), utilizing colors themselves or digital information of colors, can not only be applied to various quantitative analysis using chromaticity coordinates but can also be used to develop suitable sensors for visual colorimetry based on the characteristics of human visual perception by virtual simulations based on digital color information. To achieve a clear visual color variation for lithium ion determination, we designed and prepared a color-changeable film sensor (film optode) by the use of two kinds of lipophilic dyes, KD-C4 and KD-M11, whose colors and pKa values are different. This film sensor is a plasticized PVC membrane containing the mixture of two kinds of dyes with the lithium ionophore TTD14C4 and the lipophilic anionic additive tetrakis-[3,5-bis(trisfluoromethyl)phenyl]borate sodium salt dihydrate. The simulation of the color variation using the mixed dyes was evaluated by plotting the values on a uniform chromaticity scale diagram in a*b* coordinates, after converting the tristimulus values of each dye into its L*a*b* values. When the lithium ion concentration was actually determined by the PVC film optode containing the mixed dyes whose molecular ratio of KD-C4/KD-Ml 1 was 3:1, the hues of red --> orange --> yellow --> green --> blue could be realized in the range of 10(-6)-1 M. This observed color variation was similar to the result of the virtual simulation based on DCA.