gebhart/patrepeval huggingface dataset:
Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells. (1997)

Expression of the Mr 33,000 human Pim-1 protein is induced in hematopoietic cells by a variety of growth factors and cytokines. We have introduced the human pim-1 cDNA via retroviral transduction into interleukin (IL)-3-dependent FDC-P1 cells and examined the resulting phenotype. Compared with cells infected with a neo-encoding retrovirus (FD/neo), cells infected with a pim-1-transducing virus (FD/hpim) showed longer survival or autonomous growth in suspension culture in the absence of IL-3, as well as IL-3-independent clonogenic growth in semisolid medium. The unique murine Mr 44,000 Pim-1 protein, as well as human proteins with short C- or N-terminal truncations, also was biologically active. This effect of Pim-1 expression was associated with a decrease in apoptotic cells and an increase in G0/G1-phase cells, and the increase in G0/G1-phase cells caused by enforced expression of Pim-1 was due to a decrease in apoptosis rather than to a decrease in transit of the G1-S-phase checkpoint. The Pim-1 kinase appears to function primarily as a survival factor in factor-dependent FDCP-1 cells subjected to either cytokine withdrawal or exposure to cytotoxic agents.
Pricing sponsored content in wireless networks with multiple content providers (2015)

We study the problem faced by a wireless network operator when offering a “sponsored content” service to multiple content providers. We consider a sequential setting for deciding how much content to sponsor in advance of a fixed time period (e.g. a month). The service provider first sets prices for sponsoring and then the content providers react by deciding how much content to sponsor. Finally the end users react by accessing content depending on what has been sponsored. We consider the case of multiple content providers and derive mechanisms that should be followed by the service provider for pricing their sponsored content offerings. In this setting it is important to consider all content providers in a single optimization since they share a common pool of service provider bandwidth. Our solutions differ depending on whether the demand to each content provider is deterministic or stochastic and on whether the service provider is allowed to set individual prices to the different content providers.
PET Imaging of Prostate Cancer Xenografts with a Highly Specific Antibody against the Prostate-Specific Membrane Antigen (2009)

Because of the high and specific uptake of (64)Cu-labeled mAb 3/A12 in PSMA-positive tumors, this ligand represents an excellent candidate for prostate cancer imaging and potentially for radioimmunotherapy.
An analysis of the proxy problem in distributed systems (2002)

The authors look at the problem of delegation of rights or proxy in distributed object systems. Two signature-based schemes for achieving delegation which require different inter-object trust assumptions are presented. These schemes have been instantiated using public key and secret key based cryptographic techniques. Additional trust implications which arise from these implementations are also considered. Then the authors consider the issue of revocation of delegations and propose several ways of achieving this. These solutions have been compared with the mechanism found in the Distributed System Security Architecture (M. Gasser et al., 1990). Finally, the authors consider the Kerberos authentication system (J. Steiner et al., 1988) and propose extensions to implement the delegation scheme.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Maximum Pressure Policies in Stochastic Processing Networks (2005)

Complex systems like semiconductor wafer fabrication facilities (fabs), networks of data switches, and large-scale call centers all demand efficient resource allocation. Deterministic models like linear programs (LP) have been used for capacity planning at both the design and expansion stages of such systems. LP-based planning is critical in setting a medium range or long-term goal for many systems, but it does not translate into a day-to-day operational policy that must deal with discreteness of jobs and the randomness of the processing environment. A stochastic processing network, advanced by J. Michael Harrison (2000, 2002, 2003), is a system that takes inputs of materials of various kinds and uses various processing resources to produce outputs of materials of various kinds. Such a network provides a powerful abstraction of a wide range of real-world systems. It provides high-fidelity stochastic models in diverse economic sectors including manufacturing, service, and information technology. We propose a family of maximum pressure service policies for dynamically allocating service capacities in a stochastic processing network. Under a mild assumption on network structure, we prove that a network operating under a maximum pressure policy achieves maximum throughput predicted by LPs. These policies are semilocal in the sense that each server makes its decision based on the buffer content in its serviceable buffers and their immediately downstream buffers. In particular, their implementation does not use arrival rate information, which is difficult to collect in many applications. We also identify a class of networks for which the nonpreemptive, non-processor-splitting version of a maximum pressure policy is still throughput optimal. Applications to queueing networks with alternate routes and networks of data switches are presented.
Breakdown of the band-gap-common-cation rule:  The origin of the small band gap of InN (2003)

It is well accepted that the band gap of a semiconductor compound increases as the atomic number decreases. However, recent measurements of the small band gap of InN ${(E}_{g}\ensuremath{\sim}0.9\mathrm{eV})$ suggest that this rule may not hold for the common-cation In compounds. Using a band-structure method that includes band-gap correction, we systematically study the chemical trends of the band-gap variation in III-V semiconductors. The calculated InN band gap is $0.85\ifmmode\pm\else\textpm\fi{}0.1\mathrm{eV},$ much smaller than previous experimental value of $\ensuremath{\sim}1.9\mathrm{eV}.$ The InN band-gap anomaly is explained in terms of atomic-orbital energies and the band-gap deformation potentials.
Studies on Polynucleotides, C A Novel Joining Reaction Catalyzed by the T4-Polynucleotide Ligase (1970)

The polynucleotide ligase isolated from T4-infected Escherichia coli was previously shown to bring about repair of breaks in the single strands of bihelical DNA. The present work shows that the enzyme can also catalyze the joining of DNA duplexes at their base-paired ends. This novel reaction occurs when the deoxynucleoside at a 5'-end carries a phosphate group and the complementary deoxynucleoside opposite to it carries a 3'-hydroxyl group. The consequence is the lengthening of the original duplex to form dimers or oligomers depending upon whether one or both ends are base-paired.
THE SCHMIDT REACTION WITH 3-ETHOXYCARBONYL-4-PIPERIDONES AND THE SYNTHESIS OF SIX 5-HOMOPIPERAZINONES1 (1954)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTTHE SCHMIDT REACTION WITH 3-ETHOXYCARBONYL-4-PIPERIDONES AND THE SYNTHESIS OF SIX 5-HOMOPIPERAZINONES1S. C. DICKERMAN and A. J. BESOZZICite this: J. Org. Chem. 1954, 19, 12, 1855–1861Publication Date (Print):December 1, 1954Publication History Published online1 May 2002Published inissue 1 December 1954https://pubs.acs.org/doi/10.1021/jo01377a001https://doi.org/10.1021/jo01377a001research-articleACS PublicationsRequest reuse permissionsArticle Views231Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53 (1993)

The central role of the p53 tumor suppressor gene product in oncogenesis is gradually being clarified. Point mutations in the p53 tumor suppressor gene are common in most human cancers and are often associated with p53 protein overexpression. Overexpressed wild-type or mutant determinants of the p53 protein thus represent an attractive target for immunotherapy of cancer directed against a structure involved in malignant transformation. An important step towards this goal is identification of epitopes of p53 that can be recognized by human cytotoxic T lymphocytes. We identified peptides of (mutant) p53 capable of binding to HLA-A2.1 in an in vitro assay. These HLA-A2.1-binding peptides were utilized for in vitro induction of primary cytotoxic T lymphocyte responses using a human processing-defective cell line (174CEM.T2) as antigen-presenting cell. These cells display "empty" HLA class I surface molecules, that can efficiently be loaded with a single peptide. We obtained CD8+ cytotoxic T lymphocyte clones capable of specifically lysing target cells loaded with wild-type or tumor-specific mutant p53 peptides. This strategy allows the in vitro initiation of human cytotoxic T lymphocyte responses against target molecules of choice.
Reconfigurable Multi-Band Mixer for SDR System (2007)

A reconfigurable multi-band mixer for the SDR system is proposed. The proposed reconfigurable mixer is operated between <TEX>$850\;MHz{\sim}2\;GHz$</TEX>, which includes all commercial mobile communication service. Because the varactor diodes are used to select a specific frequency and to adjust the impedance characteristic of the selected frequency band, the proposed reconfigurable mixer can be achieved to similar performance across all of the tuning range. In addition, the designed reconfigurable mixer is applicable for the SDR system since it has a single signal path for the multi-band signals and wide band tuning range.
Detection and Titer Estimation of Escherichia coli Using Aptamer‐Functionalized Single‐Walled Carbon‐Nanotube Field‐Effect Transistors (2008)

Bug detectors: Multiple arrays of aptamer-functionalized single-walled carbon-nanotube field-effect transistors (SWNT-FETs) can be combined with the most probable number method as a simple, fast screening platform for the detection of microorganisms. The picture indicates the binding events of Escherichia coli on such SWNT-FET arrays, which showed a conductance decrease of more than 50% after binding.
Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics (2012)

We have discovered a novel chemical class of inhibitors of the EphB4 tyrosine kinase by fragment-based high-throughput docking followed by explicit solvent molecular dynamics simulations for assessment of the binding mode. The synthesis of a single derivative (compound 7) of the hit identified in silico has resulted in an improvement of the inhibitory potency in an enzymatic assay from 8.4 μM to 160 nM and a ligand efficiency of 0.39 kcal/mol per non-hydrogen atom. Such remarkable improvement in affinity is due to an additional hydroxyl group involved in two favorable (buried) hydrogen bonds as predicted by molecular dynamics and validated by the crystal structure of the complex with EphA3 solved at 1.7 Å resolution.
Using the wisdom of the crowds for keyword generation (2008)

In the sponsored search model, search engines are paid by businesses that are interested in displaying ads for their site alongside the search results. Businesses bid for keywords, and their ad is displayed when the keyword is queried to the search engine. An important problem in this process is 'keyword generation': given a business that is interested in launching a campaign, suggest keywords that are related to that campaign. We address this problem by making use of the query logs of the search engine. We identify queries related to a campaign by exploiting the associations between queries and URLs as they are captured by the user's clicks. These queries form good keyword suggestions since they capture the wisdom of the crowd as to what is related to a site. We formulate the problem as a semi-supervised learning problem, and propose algorithms within the Markov Random Field model. We perform experiments with real query logs, and we demonstrate that our algorithms scale to large query logs and produce meaningful results.
Triple band microstrip patch antenna using a spur-line filter and a perturbation segment technique (1993)

A triple-band microstrip patch antenna is demonstrated by using a spur-line bandstop filter and a perturbation segment technique. This multifrequency operation can be obtained without increasing either the size or the thickness of the patch. In addition, through experimental results, the characteristics in all channels are shown to be nearly identical.
Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. (1992)

A splice variant of the metabotropic glutamate receptor (mGluR) 1a, named mGluR1c, was isolated. Compared to mGluR1a, the predicted mGluR1c protein is 302 amino acids shorter at its C-terminal end. Despite this difference, mGluR1c activates phospholipase C in Xenopus oocytes with a pharmacological profile identical to that of mGluR1a. However, in contrast to the large fast transient responses induced by mGluR1a, mGluR1c receptors elicit a small more slowly generated long-lasting oscillatory current, suggesting that these two receptors do not generate the same pattern of Ca2+ release in Xenopus oocytes. In situ hybridization data show that mGluR1c mRNA is expressed at a lower level than the other splice variants of mGluR1. Some differences in the regional distribution of these transcripts were observed in the cerebellum, the olfactory bulb, and the striatum.
Pharmacokinetics and safety of continuously applied lidocaine patches 5% (2002)

The pharmacokinetics, safety, and tolerability of four topical lidocaine patches 5% continuously applied for 72 hours and changed every 12 or 24 hours were examined. In this randomized, prospective, multiple-dose, open-label pharmacokinetic study, lidocaine patches were applied to healthy men and women for three consecutive days. Ten subjects received four lidocaine patches every 24 hours (group 1), and 10 subjects received four patches every 12 hours (group 2). Serial samples of venous blood were obtained to determine pharmacokinetic data. Overall tolerability and safety were assessed, and skin sensory testing was conducted to determine whether local anesthetic activity was produced. The mean maximum plasma lidocaine concentrations at steady state with lidocaine patches applied in groups 1 and 2 were 186 and 225 ng/mL, respectively, compared with the reported mean maximum plasma concentration of 130 ng/ml. with the labeled dosage (12 hr/day). The area under the concentration-time curve for one dosage interval at steady state was 3550 and 4506 ng.hr/mL for groups 1 and 2, respectively. No loss in sensation at the application site was reported. No patient had edema, and most cases of erythema were very slight. No systemic adverse events were judged to be related to the patches. Continuous application for 72 hours of four lidocaine patches 5%, changed every 12 or 24 hours, produced plasma lidocaine concentrations that remained well below those that typically produce antiarrhythmic effects or toxicity. Mild application-site erythema occurred in most patients, but no systemic adverse reactions were judged to be related to the patches. No loss in sensation at the application site was reported.
Heterojunction bipolar transistors implemented with GaInNAs materials (2002)

Use of GaInNAs in the base of heterojunction bipolar transistors (HBTs) on GaAs substrates allows a reduction of the turn-on voltage, Vbe,on, of the devices, facilitating their use in applications with low power supply voltage (particularly battery operated power amplifiers for mobile communications). Using GaInNAs with N content below 2% and In content of 1–20%, HBTs have been demonstrated with Vbe,on values lower by 25–400 mV than those of conventional GaAs-based HBTs. The GaInNAs base regions exhibit lower diffusion length than conventional GaAs bases, which reduces current gain and detracts from high-frequency performance, as well as higher base sheet resistance. These adverse effects can be mitigated by proper design tradeoffs of base thickness and nitrogen composition, as well as by compositional grading in the base to provide a built-in quasi-electric field to assist electron transport.
The blood coagulation cascade (2004)

Continued progress in this field offers opportunity for understanding the basis of thrombotic diseases and bleeding disorders, with the potential for defining novel targets for therapeutic applications. Some of the conclusions reviewed are conflicting, and further work will be necessary to place the results in the context of what has already been established. The structural biology of the coagulation proteins and understanding of hemostasis and thrombosis in a physiologic context have important implications for future work.
Translocation of Vibrio harveyi N,N'-diacetylchitobiase to the outer membrane of Escherichia coli (1987)

The gene encoding N,N'-diacetylchitobiase (chitobiase) of the chitinolytic marine bacterium Vibrio harveyi has been isolated. While expression of the chitobiase gene (chb) was inducible by N,N'-diacetylchitobiose in V. harveyi, it was expressed constitutively when cloned in Escherichia coli, suggesting that controlling elements are not closely linked to chb. Chitobiase was found in the membrane fraction of E. coli cells containing plasmids with the cloned V. harveyi chb gene. When membranes of such cells were separated on Osborn gradients, chitobiase activity was found mainly in the outer membrane band. Translocation of the enzyme to the outer membrane was accompanied by cleavage of a signal peptide. A fusion protein, in which 22 amino acids from the amino terminus of prechitobiase were replaced with 21 amino acids from the pUC19 lacZ amino terminus, was not processed, and 99% of the activity was located in the cytoplasmic fraction. A homology to six amino acids surrounding the lipoprotein processing and modification site was found near the amino terminus of prechitobiase.
Disrupting Prefrontal Cortex Prevents Performance Gains from Sensory-Motor Training (2013)

Humans show large and reliable performance impairments when required to make more than one simple decision simultaneously. Such multitasking costs are thought to largely reflect capacity limits in response selection (Welford, 1952; Pashler, 1984, 1994), the information processing stage at which sensory input is mapped to a motor response. Neuroimaging has implicated the left posterior lateral prefrontal cortex (pLPFC) as a key neural substrate of response selection (Dux et al., 2006, 2009; Ivanoff et al., 2009). For example, activity in left pLPFC tracks improvements in response selection efficiency typically observed following training (Dux et al., 2009). To date, however, there has been no causal evidence that pLPFC contributes directly to sensory-motor training effects, or the operations through which training occurs. Moreover, the left hemisphere lateralization of this operation remains controversial (Jiang and Kanwisher, 2003; Sigman and Dehaene, 2008; Verbruggen et al., 2010). We used anodal (excitatory), cathodal (inhibitory), and sham transcranial direct current stimulation (tDCS) to left and right pLPFC and measured participants' performance on high and low response selection load tasks after different amounts of training. Both anodal and cathodal stimulation of the left pLPFC disrupted training effects for the high load condition relative to sham. No disruption was found for the low load and right pLPFC stimulation conditions. The findings implicate the left pLPFC in both response selection and training effects. They also suggest that training improves response selection efficiency by fine-tuning activity in pLPFC relating to sensory-motor translations.
Cortical recording with silicon microelectrodes: model-based analysis of contact dimension and encapsulation changes on recorded waveforms (2005)

Brain machine interfaces represent an emerging area of neurotechnology with both basic science and clinical applications. We developed a model of intracortical microelectrode recording to address the role of contact dimensions, tissue encapsulation, and neuron position on the time course and amplitude of the voltage records. We used a multi-compartment cable model of a 3D reconstruction of a layer V cortical pyramidal neuron to determine transmembrane currents generated during action potential signaling. We coupled the neuron model to finite element models (FEM) of microelectrodes in a cortical tissue medium. The neuronal currents were applied to the FEM and the voltage record at the contact was determined as a function of time. Our results show that the recorded waveform is relatively independent of typical contact sizes (<1000 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), but local inhomogeneities in the tissue medium can substantially enhance or suppress signal amplitude. Extensions of these analyses will enable development of silicon-substrate electrodes with optimized contact shape and distribution to achieve specific recording objectives
C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation (2013)

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported. A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine intermediate (method A) provided the target acyclonucleosides in significantly higher overall yields in comparison to those obtained by method B using sylilation reaction. The phosphorylation assays of novel compounds as potential substrates for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK) showed that solely pyrimidine 5-substituted acyclonucleosides with a penciclovir-like side chain acted as a fraudulent substrates of HSV-1 TK. Moreover, the uracil derivative with penciclovir-like side chain with less bulky 2-hydroxyethyl substituent at C-5 proved to be a better substrate than the corresponding one with a 3-hydroxypropyl substituent. Therefore, this acyclonucleoside was selected as a lead compound for the development of a positron emission tomography HSV-1 TK activity imaging agent.
An Overview of Dental CAD/CAM Systems (2008)

For 20 years, exciting new developments in dental materials and computer technology have led to the success of contemporary dental computer-aided design/computer-aided manufacturing (CAD/CAM) technology.This article provides an overview of the status of current CAD/CAM systems, describes components of CAD/CAM technologies and suggests future possibilities.
Randomized Crossover Comparison of Injection Site Pain with 40 mg/0.4 or 0.8 mL Formulations of Adalimumab in Patients with Rheumatoid Arthritis (2016)

AbbVie.