gebhart/patrepeval huggingface dataset:
A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence (1991)

Journal Article A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence Get access K.H. Choo, K.H. Choo * Murdoch Institute for Research into Birth Defects, Royal Children's HospitalFlemington Road, Parkville 3052 Victoria, Australia * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Vissel, B. Vissel Murdoch Institute for Research into Birth Defects, Royal Children's HospitalFlemington Road, Parkville 3052 Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Nagy, A. Nagy Murdoch Institute for Research into Birth Defects, Royal Children's HospitalFlemington Road, Parkville 3052 Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Earle, E. Earle Murdoch Institute for Research into Birth Defects, Royal Children's HospitalFlemington Road, Parkville 3052 Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Kalitsis P. Kalitsis Murdoch Institute for Research into Birth Defects, Royal Children's HospitalFlemington Road, Parkville 3052 Victoria, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 6, 25 March 1991, Pages 1179–1182, https://doi.org/10.1093/nar/19.6.1179 Published: 25 March 1991 Article history Received: 18 December 1990 Revision received: 25 February 1991 Accepted: 25 February 1991 Published: 25 March 1991
Abrogation of tumorigenicity by MHC class II antigen expression requires the cytoplasmic domain of the class II molecule (1991)

Transfection of syngeneic MHC class II genes into the lethal mouse SaI tumor abrogates the malignancy of the tumor in the autologous host, and protects the host against subsequent challenges with the wild type class II- tumor. We have hypothesized that the transfectants induce protective immunity by functioning as APC for tumor peptides, and stimulating tumor-specific Th cells. Recent in vitro studies suggest that Ag presentation by class II-restricted APC requires the cytoplasmic domain of the class II molecule, and may involve intracellular signaling via the cytoplasmic domain. To determine if the class II cytoplasmic domain is required for enhanced tumor-specific immunity, SaI mouse sarcoma cells were transfected with syngeneic Aak and Abk genes with truncated cytoplasmic domains. These transfectants are as malignant as wild type class II- SaI cells in autologous A/J mice. Stimulation of tumor-specific immunity by class II+ tumor cells is therefore dependent on the class II cytoplasmic region, and may involve intracellular signaling events.
Recent developments in biofeedback for neuromotor rehabilitation (2006)

The original use of biofeedback to train single muscle activity in static positions or movement unrelated to function did not correlate well to motor function improvements in patients with central nervous system injuries. The concept of task-oriented repetitive training suggests that biofeedback therapy should be delivered during functionally related dynamic movement to optimize motor function improvement. Current, advanced technologies facilitate the design of novel biofeedback systems that possess diverse parameters, advanced cue display, and sophisticated control systems for use in task-oriented biofeedback. In light of these advancements, this article: (1) reviews early biofeedback studies and their conclusions; (2) presents recent developments in biofeedback technologies and their applications to task-oriented biofeedback interventions; and (3) discusses considerations regarding the therapeutic system design and the clinical application of task-oriented biofeedback therapy. This review should provide a framework to further broaden the application of task-oriented biofeedback therapy in neuromotor rehabilitation.
Interleukin-2 therapy after bone marrow or stem cell transplantation for hematologic malignancies. (1997)

The results of phase I/II trials are sufficiently encouraging to justify prospectively randomized phase III trials to determine whether rIL-2 after autologous SCT will reduce the rate of posttransplantation relapse and improve survival in patients with advanced hematologic malignancies.
Incremental Prognostic Value of Elevated Baseline C-Reactive Protein Among Established Markers of Risk in Percutaneous Coronary Intervention (2001)

Elevated baseline C-reactive protein portends heightened risk of 30-day death or myocardial infarction after coronary intervention. Coupled anatomic, clinical, and inflammatory risk stratification demonstrates strong predictive utility among patients undergoing percutaneous coronary intervention and may be useful for guiding future strategies.
Turbo coding of strongly nonuniform memoryless sources with unequal energy allocation and PAM signaling (2006)

The design of a source-controlled turbo coding scheme for the transmission of strongly nonuniform binary memoryless sources over additive white Gaussian noise (AWGN) channels is considered. The use of nonbinary signaling allows performance improvements over previous existing schemes that use binary modulation. The basic idea is to allocate more energy to the transmitted symbols associated with the information bits that occur less likely and to exploit the source nonuniformity in the decoding process. If the source and channel parameters are unknown, they can be estimated jointly with the encoding/decoding process. No performance degradation is observed in this case.
Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes (2007)

Paroxysmal nocturnal hemoglobinuria (PNH) cells are partially (type II) or completely (type III) deficient in GPI-linked complement regulatory proteins CD59 and CD55. PNH III erythrocytes circulate 6 to 60 days in vivo. Why these cells are not lysed as rapidly by complement as unprotected foreign cells, which normally lyse within minutes, remains undetermined. Factor H plays a key role in the homeostasis of complement in fluid phase and on cell surfaces. We have recently shown that a recombinant protein encompassing the C-terminus of factor H (rH19-20) specifically blocks cell-surface complement regulatory functions of factor H without affecting fluid-phase control of complement. Here we show that PNH II and III cells become highly susceptible to complement-mediated lysis by nonacidified normal human serum in vitro, when the cell surface complement-regulatory functions of factor H are blocked. The results indicate that cells deficient in surface-bound regulators are protected for extended periods of time by factor H.
Pulmonary Vein Stenosis After Catheter Ablation of Atrial Fibrillation (1998)

The complication of pulmonary vein stenosis is potentially life-threatening, and the application of radiofrequency current within the pulmonary veins with standard catheter technology should be avoided. This complication can be treated with balloon dilation, although the long-term course is unknown.
Structure—Function Studies of Endo-l,4-β-D-glucanase E2 from Thermomonospora fusca (1994)

Six different cellulases have been purified to homogeneity from the culture supernatant of a protease negative mutant of the soil bacterium, Thermomonospora fusca (1,2). Three of these enzymes are endoglucanases, two are exocellulases and one is an exocellulase with some endoglucanase activity (3). All six enzymes contain a cellulose binding domain joined by a flexible linker to a catalytic domain. When the distributions of reducing sugars between the solution and filter paper in filter paper assays of E2 and E2cd were determined, there were two soluble sugars produced for each insoluble sugar with E2 while with E2cd there was only one soluble sugar produced for each insoluble sugar (3). This result seems reasonable since the cellulose binding domain should attach the enzyme to a specific site on the substrate for a longer time than would the catalytic domain alone.
Digital spatially incoherent Fresnel holography (2007)

We present a new method for recording digital holograms under incoherent illumination. Light is reflected from a 3D object, propagates through a diffractive optical element (DOE), and is recorded by a digital camera. Three holograms are recorded sequentially, each for a different phase factor of the DOE. The three holograms are superposed in the computer, such that the result is a complex-valued Fresnel hologram. When this hologram is reconstructed in the computer, the 3D properties of the object are revealed.
P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator α1 (2004)

During thrombosis, P-selectin is expressed on the surface of activated endothelial cells and platelets. We hypothesized that targeting a plasminogen activator (PA) to P-selectin would enhance local thrombolysis and reduce bleeding risk. Previously, a urokinase (uPA)/anti-P-selectin antibody (HuSZ51) fusion protein was shown to increase fibrinolysis in a hamster pulmonary embolism model. To explore the therapeutic potential of this targeting strategy, we fused the fibrin-selective Desmodus rotundus salivary PA alpha1 (dsPA alpha 1) to HuSZ51 and compared the fibrinolytic activity of P-selectin-targeted dsPA alpha 1 (HuSZ51-dsPA alpha 1) to unmodified dsPA alpha 1 in vitro and in vivo. HuSZ51-dsPA alpha 1 and dsPA alpha 1 were expressed in CHO cells and purified to homogeneity by affinity chromatography. HuSZ51-dsPA alpha 1 bound to thrombin-activated human and dog platelets with comparable affinities to that of parental antibody SZ51. The fusion protein retained the catalytic activities of dsPA alpha 1 in chromogenic and clot lysis assays, indicating that dsPA alpha 1 is fully functional when fused to HuSZ51. Compared to dsPA alpha 1, HuSZ51-dsPA alpha 1 had similar thrombolytic efficacy in a rat pulmonary embolism model and anti-thrombotic potency in a dog model of femoral artery thrombosis. However, HuSZ51-dsPA alpha 1 was less effective in lysis of preexisting arterial thrombi in the dog model. The reduced arterial thrombolysis was not due to the pharmacokinetic properties of HuSZ51-dsPA alpha 1 because antigen level and amidolytic activity were higher in plasma from HuSZ51-dsPA alpha 1-treated groups than corresponding dsPA alpha 1-treated groups. These data indicate that the thrombolytic efficacy of HuSZ51-dsPA alpha 1 varied dependent on the physical composition of thrombi. The lack of stimulation by fibrin in arterial thrombi may contribute to the attenuated thrombolytic efficacy of HuSZ51-dsPA alpha 1 in the dog model.
Efficacy of ALA‐PDT vs blue light in the treatment of acne (2007)

From this study, the trend for ALA-PDT with blue light to be superior to blue light alone was observed, but it did not reach statistical significance. ALA-PDT had more side effects.
Local and General Factors in the Development of “Pattern” in Rhodnius Prolixus (Hemiptera) (1940)

ABSTRACT Most studies on morphogenesis have been made upon composite structures, such as eyes or appendages, whose form is controlled by the co-operation of a great number of cells. In insects, however, the tiny fragment of cuticle laid down by a single cell may possess morphological characters controlled by the activities of that cell alone. The cuticle of insects provides, therefore, an unusually simple medium for the study of morphogenesis and the nature of those processes which “determine” the activity of a given cell.
同感、具身和人际理解：从里普斯到舒茨 (2010)

谈到理解社会认知的本质，我们似乎只能在模仿理论、理论一理论或者二者的一些混合物之间选择。然而，作者在文中提出，现象学传统提供了有别于以上三者的第四个选项。首先，作者讨论了里普斯（Lipps）有关同感的阐释。接着，作者分析了舍勒、施坦（Stein）和胡塞尔批评里普斯的方式，勾勒了他们各自方案的核心特征。接下来，作者考察了舒茨（Schutz）如何承继并修改了上述三人对同感和社会认知的基本看法。最后，在结论中作者反驳了一种针对现象学方案的异议，进一步说明了现象学方案的可行性。
Pure β-ParticleEmitting Stents Inhibit Neointima Formation in Rabbits (1996)

Neointima formation in rabbits is markedly suppressed by a beta-particle-emitting stent incorporating the radioisotope 32P. In this model, a dose-response relation with this type of radioactive stent was observed, indicating that a threshold radiation dose must be delivered to inhibit neointima formation after stent placement over the long term.
How does the human brain deal with a spinal cord injury? (1998)

The primary sensorimotor cortex of the adult brain is capable of significant reorganization of topographic maps after deafferentation and de-efferentation. Here we show that patients with spinal cord injury exhibit extensive changes in the activation of cortical and subcortical brain areas during hand movements, irrespective of normal (paraplegic) or impaired (tetraplegic patients) hand function. Positron emission tomography ([15O]-H2O-PET) revealed not only an expansion of the cortical 'hand area' towards the cortical 'leg area', but also an enhanced bilateral activation of the thalamus and cerebellum. The areas of the brain which were activated were qualitatively the same in both paraplegic and tetraplegic patients, but differed quantitatively as a function of the level of their spinal cord injury. We postulate that the changes in brain activation following spinal cord injury may reflect an adaptation of hand movement to a new body reference scheme secondary to a reduced and altered spino-thalamic and spino-cerebellar input.
Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome (1996)

The systemic inflammatory response of the body to invading microorganisms, termed sepsis, leads to profound activation of the complement system. Pathophysiological concepts suggest that complement activation occurs very early in this syndrome. Thus, we discuss whether the determination of concentrations of the complement components C3a, C5a, and C3 in plasma as well as of the C3a/C3 ratio might be helpful to diagnose sepsis early. For this purpose, 33 patients from an intensive care unit were monitored for 10 days. In comparison with healthy donors, C3a levels and the C3a/C3 ratio of intensive-care-unit patients were significantly elevated (P < 0.0001) on admission. In contrast, C3 levels were significantly reduced (P < 0.0001) but increased during the study. C5a levels in the plasma of healthy donors and patients were identical. Twenty-two of 33 patients fulfilled microbiological and clinical criteria of sepsis. Eleven patients had signs of systemic inflammatory response syndrome but no microbiological evidence of sepsis. The groups could be differentiated from each other by their C3a levels or their C3a/C3 ratios during the first 24 h after the clinical onset of sepsis (P < 0.05). Septic patients in shock had higher C3a levels than normotensive septic patients, although the differences were not significant. Nonsurvivors had significantly higher C3a levels on admission than survivors (P = 0.0185). No differences were found between septic patients who developed adult respiratory distress syndrome and those who did not. Thus, determination of C3a concentrations in plasma may prove useful (i) to diagnose sepsis early, (ii) to differentiate between patients with sepsis and those with systemic inflammatory response syndrome, and (iii) to assess prognosis.
Resveratrol, a natural chemopreventive agent against degenerative diseases. (2002)

Resveratrol (3,5,4'-trihydroxystilbene) is a naturally occurring compound shown to modulate the risk of cardiovascular degenerative diseases (atherosclerosis) and inhibit chemical carcinogenesis in rodents. Various studies have demonstrated the effect of this phytoalexin on biological mechanisms involved in cardioprotection. These include modulation of lipid turnover, inhibition of eicosanoid production, prevention of the low-density lipoprotein oxidation and inhibition of platelet aggregation. Carcinogenesis in animal models can be divided at least into three stages: initiation, promotion and progression. Initiation occurs as result of interaction of a reactive form of carcinogen with DNA. Chemical carcinogens like polycyclic aromatic hydrocarbons are metabolized to reactive species by cytochrome P450 dependent enzymes activated through aryl hydrocarbon (Ah) receptor. The inhibition of tumor initiation by resveratrol most probably occurs through preventing the activation of Ah receptor. Resveratrol affects also several factors involved in tumor promotion and progression. Since tumor promoting agents alter the expression of genes whose products are associated with inflammation, chemoprevention of cardiovascular diseases and cancer may share the same common mechanisms. This includes principally modulation of the expression of growth factors and cytokines. Recently, chemopreventive properties of resveratrol have been associated with the inhibition of NF-kappaB. This transcription factor is strongly linked to inflammatory and immune responses, regulation of cell proliferation and apoptosis, thus it is important for tumor development and many other diseases including atherosclerosis. Although the mechanisms by which resveratrol interferes with the activation of NF-KB are not clear, it seems that inhibition of its degradation which is necessary for its cellular activation is the principal target. Based on the quantity and diversity of data available on the biological activity of resveratrol, it has to be considered a very promising chemoprotector and chemotherapeutic. Urgent investigations on its bioavailability and effects on in vivo systems, especially in humans, are necessary.
Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock (2008)

Cell-free plasma DNA concentrations were significantly higher in ICU and hospital nonsurvivors than in survivors and showed a moderate discriminative power regarding ICU mortality. Plasma DNA concentration was an independent predictor for ICU mortality, but not for hospital mortality, a finding that decreases its clinical value in severe sepsis and septic shock.
New trends in industrial robot controller user interfaces (2012)

Robot controller user interface is one of the most technical challenging issues for robot manufacturers because of human presence as an actor in this interaction. Many developments made for having intuitive and easy interaction between user and robot controller while complexity of the robot systems is continuously increasing.
CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events (1993)

A panel of eight different CD28 mAbs was used to analyse the structure-function relationships of the CD28 molecule. The results of binding inhibition experiments show a complex and heterogeneous pattern of inhibition; however a subgroup of mAbs was identified, namely CD28.1, CD28.3, and CD28.5, which exhibited almost identical inhibition profiles. To test the hypothesis that the different binding specificities are related to functionally distinct subregions of the CD28 molecule, the ability of each mAb to (i) induce IL-2 release and (ii) increase intracellular calcium [(Ca2+)i] in Jurkat T cells was analysed. The results show that the mAbs CD28.1, CD28.3, and CD28.5 are almost totally unable to induce IL-2 release, and their ability to increase (Ca2+)i is relatively low. All other mAbs are able to induce a marked (Ca2+)i rise, however they strongly differ in their ability to induce IL-2 release. Such differences cannot be explained by differences in the isotypes or binding kinetics of the mAbs. These results imply the existence of functionally distinct subregions on the CD28 molecule. In addition, the (Ca2+)i rise may be associated with either high or low IL-2 secretion following CD28 triggering.
Thalidomide and its analogues have distinct and opposing effects on TNF-αand TNFR2 during co-stimulation of both CD4+ and CD8+ T cells (2002)

Thalidomide (Thd) is clinically useful in a number of conditions where its efficacy is probably related to its anti-TNF-alpha activity. More recently, Thd has also been shown to co-stimulate T cells and second generation co-stimulatory (IMiD trade mark ) analogues are currently being assessed in the treatment of cancer patients. However, in contrast to their known suppressive effects during inflammatory stimuli, the effects of Thd/IMiDs on TNF-alpha and TNF receptors (TNFRs) during T cell co-stimulation are not known. We sought to determine the effect of Thd, two clinically relevant IMiDs (CC-4047, ACTIMID trade mark and CC-5013, REVIMID trade mark ) and a non-stimulatory SelCID analogue (CC-3052) on TNF-alpha production and on the expression and shedding of TNFRs during co-stimulation. We found that co-stimulation of PBMC with Thd/IMiDs, but not CC-3052, prevented alphaCD3-induced T cell surface expression of TNFR2 and thereby reduced soluble TNFR2 (sTNFR2) levels. However, there was no effect on total (surface/intracellular) TNFR2 protein expression, suggesting inhibition of trafficking to the cell membrane. The extent of co-stimulation by Thd/IMiDs (assessed by CD69/CD25 expression and IL-2/sIL-2Ralpha production) was similar for CD4+ and CD8+ T lymphocytes and correlated with TNFR2 inhibition. Co-stimulation, but not the early inhibitory effect on TNFR2, was IL-2-dependent and led to increased TNF-alpha production by both CD4+ and CD8+ T lymphocytes. The clinical relevance of this observation was confirmed by the elevation of serum TNF-alpha during REVIMID trade mark treatment of patients with advanced cancer. Together, these results suggest a possible role for TNF-mediated events during co-stimulation and contrast with the TNF inhibitory effects of Thd and its analogues during inflammatory stimuli.
Emulsion Electrospinning of a Collagen‐Like Protein/PLGA Fibrous Scaffold: Empirical Modeling and Preliminary Release Assessment of Encapsulated Protein (2011)

The effectiveness of a multifunctional scaffold produced by the electrospinning of emulsions composed of organic PLGA and aqueous collagen-like protein (denoted as Fol-8Col) solutions is demonstrated. The resultant Fol-8Col/PLGA fibrous scaffolds with homogeneous morphology have mean fiber diameters from 600 to 2,000 nm. A uniform distribution of encapsulated Fol-8Col in the fibers is observed by fluorescence microscopy. TEM is used to clarify the representative core/sheath structure of emulsion electrospun Fol-8Col/PLGA fibers. Preliminary release assessment of encapsulated Fol-8Col shows results of sustained release for more than one month from the Fol-8Col/PLGA fibrous mats. The cytocompatibility of fibroblast cell line L929 with the fibrous composite seems promosing.