gebhart/patrepeval huggingface dataset:
Effect of the components of maize on the quality of masa and tortillas during the traditional nixtamalisation process (2001)

Abstract In this work the importance of maize pericarp and germ in relation to the overall quality of masa and tortillas was studied. Alkaline‐cooking originated alterations in the outer layers of the grain. Its components were hydrated and the pericarp fraction assumed a gummy and sticky texture. During the liming process, some components from the germ, pericarp and tip cap fractions released ‘maize hull gums’, increasing the contents of xylose, galactose and D ‐glucuronic acid. The presence of gums and insolubilised germ that remained after the traditional washing of the nixtamal improved the viscosity, cohesiveness and adhesiveness of the masa and tortillas as compared to the dry masa and tortillas from nixtamal with the germ removed and from exhaustively washed nixtamal, where most of the hull gums and germ were removed. Fresh tortillas or tortillas stored for 24 h at room temperature prepared using the traditional process of nixtamalisation (washed twice) were more stretchable, elastic and resistant to tearing and cracking than tortillas prepared with exhaustively washed nixtamal or with nixtamal washed twice with the germ removed. Tortillas from nixtamal with the germ removed showed the worst texture, rollability and puffing. © 2001 Society of Chemical Industry
Molecular characterization of human prostate carcinoma cell lines (2003)

This study defines a collection of 17 genuine prostate carcinoma cell lines. This collection, although small, constitutes a variety of different types and stages of prostate cancer, while it also partly reflects the heterogeneous nature of this malignancy.
Mechanisms of Early Insulin-Sensitizing Effects of Thiazolidinediones in Type 2 Diabetes (2004)

Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in animals, short durations of TZD therapy have never been studied in humans. Among the many known actions of TZDs, increased circulating levels of the high molecular weight (HMW) multimer of adiponectin may be an important insulin-sensitizing mechanism. We examined the effects of only 21 days of 45 mg of pioglitazone (P+) versus placebo (P-) in nine subjects with type 2 diabetes (HbA(1c), 10.9 +/- 0.6%; BMI, 31.9 +/- 1.5 kg/m(2)). Total adiponectin levels increased by approximately twofold in P+ in association with increased adipose tissue gene expression. However, plasma free fatty acid and glucose levels were unchanged, and there were only minimal changes in other "adipokines." Glucose fluxes ([3-(3)H]glucose infusion) were measured during 6-h euglycemic (5 mmol/l) "pancreatic clamp" studies (somatostatin/glucagon/growth hormone) with stepped insulin levels. Pioglitazone induced marked decreases in endogenous glucose production (P+ = 0.9 +/- 0.1 vs. P- = 1.7 +/- 0.3 mg. kg(-1). min(-1); P < 0.05) at physiologic hyperinsulinemia ( approximately 50 microU/ml), which was highly correlated with an increased ratio of HMW adiponectin/total levels (r(2) = 0.90). Maximal insulin stimulation ( approximately 400 microU/ml) revealed pioglitazone-associated increases in glucose uptake (P+ = 10.5 +/- 0.9 vs. P- = 8.9 +/- 0.8 mg. kg(-1). min(-1); P < 0.05), which did not correlate with HMW or total adiponectin levels. Thus, only 21 days of pioglitazone therapy improved insulin action in humans with type 2 diabetes. Increased abundance of the HMW adiponectin multimer may contribute to the hepatic insulin-sensitizing effects of these agents.
Electron temperature measurements inside the ablating plasma of gas-filled hohlraums at the National Ignition Facility (2016)

The first measurement of the electron temperature (Te) inside a National Ignition Facility hohlraum is obtained using temporally resolved K-shell X-ray spectroscopy of a mid-Z tracer dot. Both isoelectronic- and interstage-line ratios are used to calculate the local Te via the collisional–radiative atomic physics code SCRAM [Hansen et al., High Energy Density Phys 3, 109 (2007)]. The trajectory of the mid-Z dot as it is ablated from the capsule surface and moves toward the laser entrance hole (LEH) is measured using side-on x-ray imaging, characterizing the plasma flow of the ablating capsule. Data show that the measured dot location is farther away from the LEH in comparison to the radiation-hydrodynamics simulation prediction using HYDRA [Marinak et al., Phys. Plasmas 3, 2070 (1996)]. To account for this discrepancy, the predicted simulation Te is evaluated at the measured dot trajectory. The peak Te, measured to be 4.2 keV ± 0.2 keV, is ∼0.5 keV hotter than the simulation prediction.
Infants Fed Docosahexaenoic Acid- and Arachidonic Acid-Supplemented Formula Have Decreased Incidence of Bronchiolitis/Bronchitis the First Year of Life (2006)

To assess the effect of docosahexaenoic acid and arachidonic acid supplementation in infant formula on the incidence of respiratory illnesses, pediatricians assigned infants to receive docosahexaenoic acid/arachidonic acid-supplemented formula or control formula. Anthropometrics, medical history, and illnesses were reported. Among 1342 infants, there was a higher incidence of bronchiolitis in control versus docosahexaenoic acid/arachidonic acid-supplemented groups at 5, 7, and 9 months (P < .01). Weight, length, and head circumference were similar for both groups. Infants fed formula supplemented with 0.32% docosahexaenoic acid and 0.64% arachidonic acid experienced a lower incidence of bronchiolitis compared with infants fed formula supplemented with no docosahexaenoic acid/arachidonic acid or lower levels of docosahexaenoic acid/arachidonic acid in the first year of life.
Prevention of hyperglycemia in the Zucker diabetic fatty rat by treatment with metformin or troglitazone (1996)

To determine whether metformin or troglitazone can delay the onset of diabetes in the Zucker diabetic fatty (ZDF) rat, lean control, fatty, and ZDF rats received metformin, troglitazone, or no treatment from 6 to 12 wk of age. Glucose, insulin, triglyceride (TG), and free fatty acid (FFA) levels and glucose stimulated insulin secretion by the perfused pancreas were measured. Metformin-treated rats gained significantly less weight. Both drugs prevented hyperglycemia by 12 wk in diabetic rats and significantly reduced TG and FFA levels. Insulin secretion at low glucose was elevated in untreated fatty and diabetic animals, and the increment in diabetic animals produced by glucose perfusion was attenuated compared with lean and fatty rats. Both drugs reduced basal insulin secretion in fatty and diabetic rats and improved glucose responsiveness in diabetic rats. Metformin and troglitazone delay the onset of diabetes in the ZDF rat. The significantly improved insulin secretory response of the pancreas undoubtedly contributes to the improved glucose tolerance.
Cardiac sympathetic nervous system in early essential hypertension assessed by 123I-MIBG. (1999)

During the course of establishment of essential hypertension, the washout rate becomes higher with the advance of hypertension and with the development of left ventricular hypertrophy. Thus, we suggest a strong relationship between cardiac sympathetic activity and the advance of hypertension at its early stages.
A 1.75-GHz polar modulated CMOS RF power amplifier for GSM-EDGE (2005)

This work presents a fully integrated linearized CMOS RF amplifier, integrated in a 0.18-/spl mu/m CMOS process. The amplifier is implemented on a single chip, requiring no external matching or tuning networks. Peak output power is 27 dBm with a power-added efficiency (PAE) of 34%. The amplitude modulator, implemented on the same chip as the RF amplifier, modulates the supply voltage of the RF amplifier. This results in a power efficient amplification of nonconstant envelope RF signals. The RF power amplifier and amplitude modulator are optimized for the amplification of EDGE signals. The EDGE spectral mask and EVM requirements are met over a wide power range. The maximum EDGE output power is 23.8 dBm and meets the class E3 power requirement of 22 dBm. The corresponding output spectrum at 400 and 600 kHz frequency offset is -59 dB and -70 dB. The EVM has an RMS value of 1.60% and a peak value of 5.87%.
Variational Image Deblurring - A Window into Mathematical Image Processing (2004)

To recover a sharp image from its blurry observation is the problem known as image deblurring. It frequently arises in imaging sciences and technologies, including optical, medical, and astronomical applications, and is a crucial step towards successful detections of important patterns such as abnormal tissues and surface details of a distant planet. Mathematically, image deblurring is intimately connected to backward diffusion processes (e.g., inverting the heat equation), which are notoriously unstable. As inverse problem solvers, deblurring models therefore crucially depend upon proper regularizers or conditioners that help secure stability, often at the necessary cost of losing certain highfrequency details in original clear images. Such regularization techniques can ensure the existence or uniqueness of deblurred images. In this paper, we present a comprehensive theory of image deblurring by half surveying the existent literature and half developing a systematic and general framework. Our novel efforts include presenting the physics foundations of common blurs, classifying deblurring problems, and developing both rigorous mathematical analysis on existence or uniqueness and the associated computational methods. In combination, the current work provides a window into the vast contemporary literature of mathematical image analysis and processing- its main modelling ideas and techniques, mathematical analysis involved, as well as major computational approaches.
Enhancement of Ischemia-Induced Angiogenesis by eNOS Overexpression (2015)

It remains undetermined whether continuous endothelial nitric oxide (NO) overexpression exerts angiogenic action. We surgically induced hindlimb ischemia in transgenic mice overexpressing endothelial NO synthase in the endothelium (eNOS-Tg) and studied neocapillary formation, ischemia-induced vascular endothelial growth factor (VEGF) expression, cGMP accumulation, and Akt/PKB signaling. Laser Doppler imaging revealed a markedly increased recovery of blood perfusion in ischemic limbs of eNOS-Tg mice (44% increase) compared with that in wild-type mice. Angiography showed a marked increase in basal and ischemia-induced collateral vessel formation in eNOS-Tg mice. Basal capillary densities and tissue cGMP levels were increased in eNOS-Tg mice (1.8-fold and 1.6-fold versus wild-type mice, respectively). Ischemia-induced neocapillary formation and cGMP accumulation were markedly increased in eNOS-Tg mice (3.6-fold and 4.1-fold versus preischemia levels, respectively), whereas those in wild-type mice were much less (1.8-fold and 1.5-fold, respectively). Basal and time-dependent VEGF expression in ischemic muscles did not differ between eNOS-Tg and wild-type mice. Basal and VEGF-mediated Akt phosphorylation in aortas was similar between eNOS-Tg and wild-type mice. Aortic basal eNOS expression was increased 3.3-fold, and VEGF-mediated eNOS phosphorylation was markedly induced in aortas of eNOS-Tg compared with preischemia levels (4.2-fold), whereas much smaller changes were observed in wild-type mice (1.8-fold increase). Our study demonstrates that overexpression of eNOS protein causes a marked increase in neocapillary formation in response to tissue ischemia without affecting ischemia-induced VEGF expression or VEGF-mediated Akt phosphorylation.
Absorption of phosphorus from wastewater by aged refuse excavated from municipal solid waste landfill. (2005)

Municipal solid waste(refuse) landfill stabilizes as the refuse degrades. After years of biodegradation, the refuse in the landfill becomes stabilized and aged, which may vary with the local climate, humidity, and composition of refuse placed. In this work, it is found that the refuse with an age of over 8 years at Shanghai Refuse Landfill has been significantly stabilized and sufficiently aged and is thus suitable for excavation. The 8-year old aged refuse is mechanically screened, and the fine fractions of refuse(aged refuse) with a diameter less than 2 cm are then used as a biological absorbent for removal of both inorganic and organic phosphorus in livestock wastewater and prepared aqueous solution. It is proved that the aged refuse is very effective for the quantitative removal of both types of phosphorus. The absorption mechanism is proposed. It is considered that phosphorus is firstly absorbed onto the surface of the aged refuse and then used as a substrate for the growth of microorganisms which ultimately leave the aged refuse as sludge.
Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover (2003)

Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted bile acids. The synthesis of bile acids is limited to the liver, but several enzymes in the bile acid biosynthetic pathway are expressed in extra-hepatic tissues and there also may contribute to cholesterol turnover. An example of the latter type of enzyme is cholesterol 24-hydroxylase, a cytochrome P450 (CYP46A1) that is expressed at 100-fold higher levels in the brain than in the liver. Cholesterol 24-hydroxylase catalyzes the synthesis of the oxysterol 24(S)-hydroxycholesterol. To assess the relative contribution of the 24-hydroxylation pathway to cholesterol turnover, we performed balance studies in mice lacking the cholesterol 24-hydroxylase gene (Cyp46a1-/- mice). Parameters of hepatic cholesterol and bile acid metabolism in the mutant mice remained unchanged relative to wild type controls. In contrast to the liver, the synthesis of new cholesterol was reduced by approximately 40% in the brain, despite steady-state levels of cholesterol being similar in the knockout mice. These data suggest that the synthesis of new cholesterol and the secretion of 24(S)-hydroxycholesterol are closely coupled and that at least 40% of cholesterol turnover in the brain is dependent on the action of cholesterol 24-hydroxylase. We conclude that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain.
The Properties Of The Samarium Fibre Laser (1990)

The optical properties of trivalent Samarium doped silica glass fibres are described. This material has a narrow fluorescence of 2.2 nm f.w.h.m. at a wavelength of 650 nm. Visible laser emission is obtained at this wavelength when the fibre is pumped in a Fabry Perot cavity. The performance of the laser in continuous, Q-switched and self mode-locked operation is described.
Application and validation of a urinary methadone metabolite (EDDP) immunoassay to monitor methadone compliance (2000)

A total of 1381 urine specimens were screened using a Microgenics CEDIA urinary primary methadone metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine; EDDP) immunoassay (cut-off calibrator concentration of 100 microg/L) in combination with a Dade Behring EMIT urinary methadone immunoassay (cut-off calibrator concentration of 300 microg/L). Of these, 642 (46%) were found to be positive using the EDDP assay but only 541 (39%) were found to be positive by the methadone assay. Out of the 108 specimens which were EDDP-positive but negative by the methadone assay, 47 (7%) could not be confirmed as positive using the routine in-house method of gas chromatography incorporating nitrogen-specific detection. Of these 47 results, 38 were re-screened using a more sensitive gas chromatography-mass spectrometry (GC-MS) technique, which demonstrated the presence of EDDP in every case. There was insufficient specimen to analyse the remaining nine samples. There were seven specimens which gave negative results by the EDDP and GC-MS assays but which had methadone concentrations ranging from 4000 to 37,500 microg/L. These were therefore presumed to be 'spiked' with methadone, i.e. to have had methadone added to the specimen to yield positive screening results and simulate compliance. It is concluded that the Microgenics CEDIA EDDP assay is a sensitive and reliable technique to determine the compliance of subjects prescribed methadone for opiate detoxification and maintenance.
Synthesis of 1,4-substituted imidazoles (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 1,4-substituted imidazolesPreston K. Martin, H. Randall Matthews, Henry Rapoport, and G. ThyagarajanCite this: J. Org. Chem. 1968, 33, 10, 3758–3761Publication Date (Print):October 1, 1968Publication History Published online1 May 2002Published inissue 1 October 1968https://pubs.acs.org/doi/10.1021/jo01274a016https://doi.org/10.1021/jo01274a016research-articleACS PublicationsRequest reuse permissionsArticle Views1179Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrochemical activity of Fe-MIL-100 as a positive electrode for Na-ion batteries (2016)

MOFs' feasibility as cathodes for Na-ion batteries is probed, revealing the complex interplay between battery components and overall performance.
Morphology of mouse egg cylinder development in vitro: A light and electron microscopic study (1977)

Abstract Phase contrast, light, and electron microscopy showed that mouse egg cylinder development from the blastocyst stage in vitro closely resembled the egg cylinder stages of the fourth to seventh days of gestation in vivo. Primary endoderm and ectoderm formed on day 2 of culture, and on day 3 visceral and parietal endoderm could be distinguinshed. Mesoderm formed on days 6.5‐7 by delaminating from a thickened region of embryonic ectoderm. Extraembryonic ectoderm developed as single layer of cuboidal epithelial cells that appeared to originate from polar trophoblast cells. By day 8 of culture egg cylinders had an ectoplacental cavity, an exocoelom, a proamnionic cavity, a chorion, and an allantois and resembled egg cylinders in vivo after seven days' gestation. However, cultured blastocysts took longer to develop to these egg cylinder stages than embryos in vivo (8 days in vitro vs. 4 days in vivo) and were shorter (600 μm in vitro vs. 700 μm in vivo). The development of mural trophoblast, parietal endoderm, Reichert's membrane, and ectoplacental cone also differed from that of their counterparts in vivo. Nevertheless, because the egg cylinder itself, which produces the embryo proper, develops similarly in vitro as in vivo, we suggest that cultured mouse blastocysts provide an excellent model for studies on early postimplantation embryogenesis.
An Efficient Approach to Adaptive-Implicit Compositional Simulation With an Equation of State (1992)

Summary This paper describes a robust and efficient method for solving the equations corresponding to an equation-of-state (EOS) compositional model. The method is developed for an adaptive-implicit simulator in which only a small number of blocks need to be solved implicitly while the remaining blocks are solved explicitly. The salient features of the method are decoupling of the solution of flow equations from the flash calculations and switching from explicit to implicit formulations on the basis of a stability criterion. The performance of the adaptive-implicit approach is compared with that of a hilly implicit approach and an explicit-transmissibility approach. Results show that the adaptive-implicit approach is two to three times faster than the other two methods.
Highly Efficient CRISPR/HDR-Mediated Knock-in for Mouse Embryonic Stem Cells And Zygotes (2015)

The clustered regularly interspaced short palindromic repeat (CRISPR) gene editing technique, based on the non-homologous end-joining (NHEJ) repair pathway, has been used to generate gene knock-outs with variable sizes of small insertion/deletions with high efficiency. More precise genome editing, either the insertion or deletion of a desired fragment, can be done by combining the homology-directed-repair (HDR) pathway with CRISPR cleavage. However, HDR-mediated gene knock-in experiments are typically inefficient, and there have been no reports of successful gene knock-in with DNA fragments larger than 4 kb. Here, we describe the targeted insertion of large DNA fragments (7.4 and 5.8 kb) into the genomes of mouse embryonic stem (ES) cells and zygotes, respectively, using the CRISPR/HDR technique without NHEJ inhibitors. Our data show that CRISPR/HDR without NHEJ inhibitors can result in highly efficient gene knock-in, equivalent to CRISPR/HDR with NHEJ inhibitors. Although NHEJ is the dominant repair pathway associated with CRISPR-mediated double-strand breaks (DSBs), and biallelic gene knock-ins are common, NHEJ and biallelic gene knock-ins were not detected. Our results demonstrate that efficient targeted insertion of large DNA fragments without NHEJ inhibitors is possible, a result that should stimulate interest in understanding the mechanisms of high efficiency CRISPR targeting in general.
A specific binding site for K+ channel openers in rat aorta. (1992)

The K+ channel openers, including cromakalim, pinacidil, minoxidil sulfate, diazoxide, and nicorandil, form a chemically heterogeneous group of compounds, which relax smooth muscle by opening plasmalemmal K+ channels. At present it is not known whether these drugs elicit their effects by binding to the same target, presumably the K+ channel. In order to address this question, a binding assay for K+ channel openers has been developed in vascular smooth muscle. The novel tritiated K+ channel opener, [3H]P1075, an analogue of pinacidil, binds with high affinity (KD = 6 +/- 1 nM) to endothelium-denuded rings of rat aorta. Inhibition studies indicate that the different families of K+ channel openers bind to a common target. Evidence is presented to suggest that the binding site for the sulfonylurea, glibenclamide, the major blocker of the K+ channel openers, is coupled in a negative allosteric manner to the binding site(s) for the openers. The binding assay described here may open the way to the biochemical characterization of the drug receptor for the K+ channel openers.