gebhart/patrepeval huggingface dataset:
A reconfigurable filter bank for uniform and non-uniform channelization in multi-standard wireless communication receivers (2010)

In a typical multi-standard wireless communication receiver, the channelizer extracts multiple radio channels of distinct bandwidths from a digitized wideband input signal. The complexity of the digital front end of the receiver is dominated by the complexity of the channelizer which operates at the highest sampling rate in the system. Computationally efficient architecture is essential for cost-effective implementation of the channelizer. Reconfigurability is another key requirement in the channelizer to support different communication standards. In this paper, we propose a low complexity reconfigurable filter bank (FB) channelizer based on coefficient decimation, interpolation and frequency masking techniques. Design example shows that the proposed FB offers complexity reduction of 54.8% over modulated perfect reconstruction FB and 10.5% over discrete Fourier transform FB. Furthermore, the proposed FB has an added advantage of dynamic reconfigurability over these FBs.
A Cooperative, Self-Configuring High-Availability Solution for Stream Processing (2007)

We present a collaborative, self-configuring high availability (HA) approach for stream processing that enables low-latency failure recovery while incurring small run-time overhead. Our approach relies on a novel fine-grained checkpointing model that allows query fragments at each server to be backed up at multiple other servers and recovered collectively (in parallel) when there is a failure. In this paper, we first address the problem of determining the appropriate query fragments at each server. We then discuss, for each fragment, which server to use as its backup as well as the proper checkpoint schedule. We also introduce and analyze operator-specific delta-checkpointing techniques to reduce the overall HA cost. Finally, we quantify the benefits of our approach using results from our prototype implementation and a detailed simulator.
Predictors of survival in systemic sclerosis (Scleroderma) (1991)

We conducted followup of 264 patients with definite systemic sclerosis (SSc) who were entered into the multicenter Scleroderma Criteria Cooperative Study (SCCS) during 1973-1977. At the end of the study (average 5.2 years of followup), 38% were known to be alive, 50% were dead (68% of these deaths definitely related to SSc), and 12% were lost to followup. Survival analyses of 484 demographic, clinical, and laboratory items recorded at entry into the SCCS (within 2 years of physician diagnosis of SSc) were performed. Survival declined linearly, and the cumulative survival rate was less than 80% at 2 years, 50% at 8.5 years, and 30% at 12 years after entry. Analysis using combinations of entry variables identifying organ system involvement confirmed that renal, cardiac, pulmonary, and gastrointestinal involvement in SSc predicted reduced survival; however, data on organ system involvement at study entry could not be used to consistently predict which organ system would ultimately be involved as the primary cause of death. By survival tree analysis, the individual entry variables best predicting reduced survival included older age (greater than 64 years), reduced renal function (blood urea nitrogen greater than 16 mg/dl), anemia (hemoglobin less than or equal to 11 gm/dl), reduced pulmonary diffusing capacity for carbon monoxide (less than or equal to 50% of predicted), reduced total serum protein level (less than or equal to 6 gm/dl), and reduced pulmonary reserve (forced vital capacity less than 80% with hemoglobin greater than 14 gm/dl or forced vital capacity less than 65% with hemoglobin less than or equal to 14 gm/dl). Cox proportional hazards model analysis confirmed these results. Different combinations of variables led to markedly different survival rates. The poorest prospects for survival were in patients with SSc who were less than or equal to 64 years old with a hemoglobin level less than or equal to 11 gm/dl, and in those greater than 64 years old with a blood urea nitrogen level greater than 16 mg/dl. These results may be useful in predicting individual patients at risk for shortened survival.
Improved Subthreshold Slope in an InAs Nanowire Heterostructure Field-Effect Transistor (2006)

An n-type InAs/InAsP heterostructure nanowire field-effect transistor has been fabricated and compared with a homogeneous InAs field-effect transistor. For the same device geometry, by introduction of the heterostructure, the threshold voltage is shifted 4 V, the maximum current on-off ratio is enhanced by a factor of 10,000, and the subthreshold swing is lowered by a factor 4 compared to the homogeneous transistor. At the same time, the drive current remains constant for a fixed gate overdrive. A single nanowire heterostructure transistor has a transconductance of 5 muA/V at a low source-drain voltage of 0.3 V. For the homogeneous InAs transistor, we deduced a high electron mobility of 1500 cm2/Vs.
Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse (1997)

Until recently, only a single type of estrogen receptor (ER) was thought to exist and mediate the genomic effects of the hormone 17beta-estradiol in mammalian tissues. However, the cloning of a gene encoding a second type of ER, termed ERbeta, from the mouse, rat, and human has prompted a reevaluation of the estrogen signaling system. Based on in vitro studies, the ERbeta protein binds estradiol with an affinity similar to that of the classical ER (now referred to as ERalpha) and is able to mediate the effects of estradiol in transfected mammalian cell lines. Essential to further investigations of the possible physiological roles of ERbeta, and its possible interactions with ERalpha, are data on the tissue distribution of the two ER types. Herein, we have described the optimization and use of an RNase protection assay able to detect and distinguish messenger RNA (mRNA) transcripts from both the ERalpha and ERbeta genes in the mouse. Because this assay is directly quantitative, a comparison of the levels of expression within various tissues was possible. In addition, the effect of disruption of the ERalpha gene on the expression of the ERbeta gene was also investigated using the ERalpha-knockout (ERKO) mouse. Transcripts encoding ERalpha were detected in all the wild-type tissues assayed from both sexes. In the female reproductive tract, the highest expression of ERbeta mRNA was observed in the ovary and showed great variation among individual animals; detectable levels were observed in the uterus and oviduct, whereas mammary tissue was negative. In the male reproductive tract, significant expression of ERbeta was seen in the prostate and epididymis, whereas the testes were negative. In other tissues of both sexes, the hypothalamus and lung were clearly positive for both ERalpha and ERbeta mRNA. The ERKO mice demonstrated slightly reduced levels of ERbeta mRNA in the ovary, prostate, and epididymis. These data, in combination with the several described phenotypes in both sexes of the ERKO mouse, suggest that the biological functions of the ERbeta protein may be dependent on the presence of ERalpha in certain cell types and tissues. Further characterization of the physiological phenotypes in the ERKO mice may elucidate possible ERbeta specific actions.
Stomach lysozymes of ruminants. I. Distribution and catalytic properties. (1984)

A major regulatory shift affecting the expression of lysozyme c may have been involved in the origin of two groups of mammals whose nutrition depends on foregut bacteria. A survey of 23 mammalian species reveals that the lysozyme c activity per g of stomach mucosa is many times higher for ruminants and a leaf-eating monkey than for animals lacking a foregut. The implication is that stomach lysozyme c functions as a major digestive enzyme in ruminant-like mammals, helping to make those bacterial which enter the stomach from the foregut available for hydrolysis by conventional digestive enzymes. The high level of stomach lysozyme is due to more enzyme molecules rather than to an increase in the activity of each molecule. This was shown for the cow by purifying the three, non-allelic lysozymes c that account for the lysozyme activity in gastric mucosa and measuring their specific activities and for other foregut fermenters by immunological titration. Lysozyme appears in the stomach mucosa before birth and reaches adult levels before weaning. Other tissues tested from cattle lack lysozyme c and may instead have low levels of another lysozyme that could belong to the g class, the first indication that lysozyme g may be present in mammals. The lysozymes of eight ruminants, four Old World monkeys, and 12 other animals were compared as regards the ability to lyse bacterial cells under various conditions and to resist inactivation by pepsin. There are differences among these species in the dependence of the rate of bacterial lysis on time, pH, and ionic strength. Although not every lysozyme was tested in all of these catalytic respects, there were no exceptions to the following generalizations. First, at ionic strengths above 0.1 and pH values above 5, the rate of lysis by ruminant and monkey lysozymes c rose with the time of reaction, whereas the rate was more nearly constant for the other animal lysozymes. Second, the lytic activity at neutral pH is lower than at pH 5 for the ruminant and monkey lysozymes c when the ionic strength is over 0.1; by contrast, for other lysozymes c under these conditions the activity at neutral pH is about as high as at pH 5. This latter property, which may be viewed as an adaptation for functioning as a digestive enzyme in the stomach, can be explained in part by differences in electrostatic interactions between lysozyme and the substrate due to the relatively non-basic nature of ruminant and monkey lysozymes compared to other lysozymes c.(ABSTRACT TRUNCATED AT 400 WORDS)
Isolation and characterization of stem cells from the placenta and the umbilical cord. (2008)

In addition to its essential role in the development, nutrition and immunological tolerance of the product of conception, human placenta is an important source of stem cells. Over the past years, scientific research has been aimed at isolating and characterizing mesenchymal cells and amniocytes, which show a high plasticity and are found in the chorionic villi and the membranes. At the level of the umbilical cord, two types of stem cells can be found: hematopoietic and mesenchymal. The blood of the umbilical cord is already in the focus of attention of researchers, as an important source of hematopoietic stem cells that can be used for transplantation.
Synthesis of polyanhydrides: melt-polycondensation, dehydrochlorination, and dehydrative coupling (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of polyanhydrides: melt-polycondensation, dehydrochlorination, and dehydrative couplingK. W. Leong, V. Simonte, and R. LangerCite this: Macromolecules 1987, 20, 4, 705–712Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/ma00170a001https://doi.org/10.1021/ma00170a001research-articleACS PublicationsRequest reuse permissionsArticle Views1042Altmetric-Citations91LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
P67L: a cystic fibrosis allele with mild effects found at high frequency in the Scottish population. (1998)

Only three mutant cystic fibrosis (CF) alleles have to date been established as conferring a dominant mild effect on affected subjects who are compound heterozygotes. We now add a fourth, P67L, which occurs on about 1.4% of Scottish CF chromosomes. Among 13 patients (12 unrelated) with this allele, the average age at diagnosis was 22.5 +/- 11.3 years. None of the cases had consistently raised sweat chloride concentrations, the average value being 57 +/- 9 mmol/l; 77% of the patients were pancreatic sufficient. When compared to three other established mild CF alleles, R117H, A455E, and 3849 + 10kb C-T, a compound heterozygote for P67L has minimal disease and clinical suspicions are unlikely to be confirmed other than by DNA typing.
In Vivo Functional Analysis of Polyglutamic Acid Domains in Recombinant Bone Sialoprotein (2006)

Bone sialoprotein (BSP) is an anionic phosphoprotein expressed in mineralizing connective tissues that binds to hydroxyapatite and nucleates its formation in vitro. Two polyglutamic acid regions (poly [E]) are believed to participate in these activities. The aim of this study was to evaluate the contribution of these acidic regions to the binding of prokaryote recombinant BSP (prBSP(E)) within an actual in vivo environment. Full-length prBSP(E) and prBSP(E) in which the poly [E] domains were replaced by polyalanine (prBSP(A)) were tagged with dinitrophenol (DNP). Tagged preparations comprised intact molecules and some fragmented forms. They were infused through a surgically created hole in the bone of rat hemimandibles and detected using immunogold labeling with anti-DNP antibodies. prBSP(E)-DNP was consistently immunodetected along exposed mineralized bone surfaces and osteocyte canaliculi at the surgical site. Few gold particles were observed on these surfaces when prBSP(A)-DNP was infused. Quantitative analyses showed significant differences in labeling between prBSP(E)-DNP (5.04 +/- 0.73 particles/micro m2) and prBSP(A)-DNP (1.37 +/- 0.35 particles/micro m2). These results indicate that poly [E] domains influence binding of prBSP(E) to surfaces presenting a mixture of mineral and proteins bathed by tissue fluids and suggest that they may similarly mediate the interaction of native BSP in the bone environment.
A Multi-site Heart Pacing Study Using Wirelessly Powered Leadless Pacemakers (2018)

In this work, we report an energy-efficient switched capacitor based millimeter-scale pacemaker (5 mm ×7.5 mm) and a multi-receiver wireless energy transfer system operating at around 200 MHz, and use them in a proof-of-concept multi-site heart pacing study. Two pacemakers were placed on two beating Langendorff rodent heart models separately. By utilizing a single transmitter positioned 20-30 cm away, both Langendorff hearts captured the stimuli simultaneously and were electromechanically coupled. This study provides an insight for future energy-efficient and distributed cardiac pacemakers that can offer cardiac resynchronization therapies.
Genome-Wide Sequencing of Cell-Free DNA Identifies Copy-Number Alterations That Can Be Used for Monitoring Response to Immunotherapy in Cancer Patients (2018)

Inhibitors of the PD-1/PD-L1/CTLA-4 immune checkpoint pathway have revolutionized cancer treatment. Indeed, some patients with advanced, refractory malignancies achieve durable responses; however, only a subset of patients benefit, necessitating new biomarkers to predict outcome. Interrogating cell-free DNA (cfDNA) isolated from plasma (liquid biopsy) provides a promising method for monitoring response. We describe the use of low-coverage, genome-wide sequencing of cfDNA, validated extensively for noninvasive prenatal testing, to detect tumor-specific copy-number alterations, and the development of a new metric-the genome instability number (GIN)-to monitor response to these drugs. We demonstrate how the GIN can be used to discriminate clinical response from progression, differentiate progression from pseudoprogression, and identify hyperprogressive disease. Finally, we provide evidence for delayed kinetics in responses to checkpoint inhibitors relative to molecularly targeted therapies. Overall, these data demonstrate a proof of concept for using this method for monitoring treatment outcome in patients with cancer receiving immunotherapy.
Xylitol Enhances Bacterial Killing in the Rabbit Maxillary Sinus (2004)

Xylitol reduces experimental sinusitis when administered simultaneously with bacteria. Its effect in established sinusitis is less clear. A role may exist for xylitol in nasal irrigation fluid in human disease.
Lenalidomide in Multiple Myeloma—A Practice Guideline (2013)

Lenalidomide in combination with dexamethasone can be recommended for both previously untreated and treated patients with multiple myeloma. Guidelines for the management of cytopenias, venous thromboembolism, and second primary malignancies are discussed.
A Methacrylated Photoiniferter as a Chemical Basis for Microlithography:  Micropatterning Based on Photografting Polymerization (2003)

A polymer patterning technology based on photografting polymerization mediated by photoiniferter chemistry is presented as a simple microlithographic technique that affords flexibility in fabricating and subsequently modifying polymer substrates with various chemistries. In principle, the technique relies upon the design and synthesis of a methacrylated photoiniferter, (methacryloyl ethylenedioxycarbonyl) benzyl N,N-diethyldithiocarbamate (HEMA-E-In). This photoiniferter allows the production of micropatterned polymer substrates with surface or internally grafted chemical modifications. The ability to modify surfaces with covalently bound polymer is demonstrated where the thickness of the layer depends on the exposure time. Furthermore, patterning chemical surface modifications was achieved by combining this process with photomasks to produce micron-sized features (approximately 20 μm). The method is quite diverse and enables spatially controlled internal modification of polymer networks as demonstrated herein. The developed techniques should be very useful for the facile development of 2-D and 3-D patterned and surface-modified polymers for microfluidic and biomaterial applications.
Fetal Nucleic Acids in Maternal Plasma (2008)

The discovery of cell-free fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Over the last few years, a number of approaches have been demonstrated to allow such circulating fetal nucleic acids to be used for the prenatal detection of chromosomal aneuploidies. One such approach involves the enrichment of fetal DNA, such as by size fractionation or by the controversial formaldehyde treatment technique. A second approach involves the targeting of fetal-specific nucleic acid molecules, including fetal-specific epigenetic markers and placenta-specific mRNA markers. A third approach involves the development of highly discriminatory quantitative methods for chromosome dosage analysis using digital polymerase chain reaction technology. It is likely that these and other methods yet to be developed would allow noninvasive prenatal diagnosis of chromosomal aneuploidies by maternal plasma nucleic acids to be realized in the near future.
Endothelial NO Synthase Activity in Nucleus Tractus Solitarii Contributes to Hypertension in Spontaneously Hypertensive Rats (2006)

NO is implicated as a major modulator of central nervous circuits regulating cardiovascular activity. Based on previous data, we hypothesized that overactivity of endothelial NO synthase (eNOS) within the nucleus tractus solitarii (NTS) could contribute to the hypertension in the spontaneously hypertensive rat (SHR). Using real-time PCR, we found that endogenous eNOS mRNA was greater in the NTS of mature, but not juvenile prehypertensive SHRs compared with aged-matched Wistar Kyoto (WKY) rats. To test the functional significance of this, we chronically blocked eNOS activity in the NTS in the adult SHR by in vivo adenoviral-mediated gene transfer of a dominant-negative form of eNOS; data were compared with WKY rats. This resulted in a fall in arterial pressure in the SHR but not WKY rats. In both rat strains, cardiac baroreceptor reflex gain and the high-frequency spectral component of heart rate variability increased. Thus, endogenous eNOS activity in the NTS plays a major role in determining the set point of arterial pressure in the SHR and contributes to maintaining high arterial blood pressure in this animal model of human hypertension.
Mechanical Properties of Starch, Protein and Endosperm and Their Relationship to Hardness in Wheat (1992)

Various mechanical properties of whole endosperm, starch granules, and storage protein deposits were compared to determine whether the findings were consistent with the current theories on wheat hardness. All mechanical measurements were performed in situ without the use of solvents, resins, or polishing compounds that could alter the properties of the specimens. The results showed that the starch and protein components had elastic and creep properties. There were no significant differences in any of the mechanical properties of the starch and protein components either within a variety or among soft, hard, and durum wheat types. Tensile strength (Su), compressive strength (Smax), toughness (Wmax), modulus of elasticity (E) and strain to fracture (emax) were measured in samples of whole endosperm from various soft, hard, and durum wheats. The mean values for each parameter were highest for durum caryopses and lowest for non-vitreous caryopses of soft wheats. The hard wheat samples were intermediate. The mechanical properties of some vitreous caryopses of two soft wheat varieties were comparable to those of durum and hard wheat caryopses. These results do not support theories that suggest endosperm hardness is directly attributable to a cell product made exclusively in either hard or soft wheat varieties.
Importance of Facies-Based Earth Models for Understanding Flow Behavior in Carbonate Reservoirs (2007)

Reservoir models attempt to mimic the distribution of reservoir properties in subsurface systems, and in carbonate reservoirs should capture geologically meaningful and realistic heterogeneity. Comparing SGS-generated models with facies-based Multiple-Point Statistics (MPS)/Facies Distribution Models (FDM) highlights the importance of incorporating facies into models. These facies-based models provide a template to test which carbonate characteristics have the greatest impact on subsurface flow.