gebhart/patrepeval huggingface dataset:
Image coding based on mixture modeling of wavelet coefficients and a fast estimation-quantization framework (2002)

We introduce a new image compression paradigm that combines compression efficiency with speed, and is based on an independent "infinite" mixture model which accurately captures the space-frequency characterization of the wavelet image representation. Specifically, we model image wavelet coefficients as being drawn from an independent generalized Gaussian distribution field, of fixed unknown shape for each subband, having zero mean and unknown slowly spatially-varying variances. Based on this model, we develop a powerful "on the fly" estimation-quantization (EQ) framework that consists of: (i) first finding the maximum-likelihood estimate of the individual spatially-varying coefficient field variances based on causal and quantized spatial neighborhood contexts; and (ii) then applying an off-line rate-distortion (R-D) optimized quantization/entropy coding strategy, implemented as a fast lookup table, that is optimally matched to the derived variance estimates. A distinctive feature of our paradigm is the dynamic switching between forward and backward adaptation modes based on the reliability of causal prediction contexts. The performance of our coder is extremely competitive with the best published results in the literature across diverse classes of images and target bitrates of interest, in both compression efficiency and processing speed. For example, our coder exceeds the objective performance of the best zerotree-based wavelet coder based on space-frequency-quantization at all bit rates for all tested images at a fraction of its complexity.
A Distributed Approach for Secure M2M Communications (2012)

A key establishment solution for heterogeneous Machine to Machine (M2M) communications is proposed. Decentralization in M2M environment leads to situations where highly resource-constrained nodes have to establish end-to-end secured contexts with powerful remote servers, which would normally be impossible because of the technological gap between these classes of devices. This paper proposes a novel collaborative session key exchange method, wherein a highly resource-constrained node obtains assistance from its more powerful neighbors when handling costly cryptographic operations. Formal security analysis and performance evaluation of this method are provided; they confirm the safety and efficiency of the proposed solution.
Platelet Rich Plasma in Rotator Cuff Repair (2007)

Despite clinical success rates over 85%, persistent anatomic defects after rotator cuff repair are common and depend on the size of the tear repaired. The etiology of delayed or failed tendon to bone healing is multifactorial and biologic augmentation of a rotator cuff repair would be clinically desirable. Autogenous platelets contain many growth factors and are critical in the physiology of bone, soft tissue, and wound healing. Growth factors present in platelets include TGF-B, FGF, PDGF, EGF, and VEGF. Centrifugation techniques have been developed to create platelet rich plasma (PRP). These PRP preparations are designed to concentrate platelets and the growth factors they provide. PRP has been used to augment healing in various animal models as well as clinical situations in humans. This review examines the potential of using PRP to augment rotator cuff repair.
Age-Associated Remodeling of Thymopoiesis: Role for Gonadal Hormones and Catecholamines (2008)

The present review summarizes recent data on age-related thymic changes termed thymic involution, and highlights the putative role of perturbances in extrathymical and, possibly, intrathymical production of gonadal steroids and catecholamines in this process. Thymic involution has been envisaged as an extremely complex process involving multifactorial mechanisms along the bone marrow-thymic axis that accounts for the major manifestations of immunosenescence. These mechanisms include basic cell aging processes (for example, cell replication and programmed cell death) and processes unique to the immune system (such as generation of the T cell receptor repertoire and control of potentially autoreactive cells). Given that the onset of age-associated thymic involution coincides with the rise in gonadal steroid levels at puberty, a causal link between these events has been suggested. It has been shown that: (1) peripubertal gonadectomy causes substantial decrease in the level of noradrenaline in adult male and female thymus and (2) catecholamines, acting via alpha- and beta-adrenoceptor, produce suppressive effects on the thymic cellularity and production of both effector and regulatory T cells. Furthermore, the possibility that gonadal steroids contribute to thymic involution is discussed in this paper. In light of recent data indicating that effects of gonadal hormone deprivation on the thymic cellularity and function are long lasting but transitory, a putative role for the intrathymic sex steroid/catecholamine production in assuring the organ involution, under conditions of their limited supply by extrathymic sources, is also considered.
Maternal serum C‐reactive protein in early pregnancy and occurrence of preterm premature rupture of membranes and preterm birth (2012)

It seems that the inflammatory marker, CRP, can be used in the early stages of pregnancy to identify women at risk of experiencing preterm premature rupture of membranes and preterm birth.
Combining linguistic and machine learning techniques for email summarization (2001)

This paper shows that linguistic techniques along with machine learning can extract high quality noun phrases for the purpose of providing the gist or summary of email messages. We describe a set of comparative experiments using several machine learning algorithms for the task of salient noun phrase extraction. Three main conclusions can be drawn from this study: (i) the modifiers of a noun phrase can be semantically as important as the head for the task of gisting, (ii) linguistic filtering improves the performance of machine learning algorithms, (iii) a combination of classifiers improves accuracy.
Efficient Light Trapping in Inverted Nanopyramid Thin Crystalline Silicon Membranes for Solar Cell Applications (2012)

Thin-film crystalline silicon (c-Si) solar cells with light-trapping structures can enhance light absorption within the semiconductor absorber layer and reduce material usage. Here we demonstrate that an inverted nanopyramid light-trapping scheme for c-Si thin films, fabricated at wafer scale via a low-cost wet etching process, significantly enhances absorption within the c-Si layer. A broadband enhancement in absorptance that approaches the Yablonovitch limit (Yablonovitch, E. J. Opt. Soc. Am.1987, 72, 899-907 ) is achieved with minimal angle dependence. We also show that c-Si films less than 10 μm in thickness can achieve absorptance values comparable to that of planar c-Si wafers thicker than 300 μm, amounting to an over 30-fold reduction in material usage. Furthermore the surface area increases by a factor of only 1.7, which limits surface recombination losses in comparison with other nanostructured light-trapping schemes. These structures will not only significantly curtail both the material and processing cost of solar cells but also allow the high efficiency required to enable viable c-Si thin-film solar cells in the future.
pH‐Induced conformational changes of membrane‐bound influenza hemagglutinin and its effect on target lipid bilayers (1998)

Influenza virus hemagglutinin (HA) has served as a paradigm for both pH-dependent and -independent viral membrane fusion. Although large conformational changes were observed by X-ray crystallography when soluble fragments of HA were subjected to fusion-pH conditions, it is not clear whether the same changes occur in membrane-bound HA, what the spatial relationship is between the conformationally changed HA and the target and viral membranes, and in what way HA perturbs the target membrane at low pH. We have taken a spectroscopic approach using an array of recently developed FTIR techniques to address these questions. Difference attenuated total reflection FTIR spectroscopy was employed to reveal reversible and irreversible components of the pH-induced conformational change of the membrane-bound bromelain fragment of HA, BHA. Additional proteolytic fragments of BHA were produced which permitted a tentative assignment of the observed changes to the HA1 and HA2 subunits, respectively. The membrane-bound HA1 subunit undergoes a reversible conformational change, which most likely involves the loss of a small proportion of beta-sheet at low pH. BHA was found to undergo a partially reversible tilting motion relative to the target membrane upon exposure to pH 5, indicating a previously undescribed hinge near the anchoring point to the target membrane. Time-resolved amide H/D exchange experiments revealed a more dynamic (tertiary) structure of membrane-bound BHA and its HA2, but not its HA1, subunit. Finally BHA and, to a lesser degree, HA1 perturbed the lipid bilayer of the target membrane at the interface, as assessed by spectral changes of the lipid ester carbonyl groups. These results are discussed in the context of a complementary study of HA that was bound to viral membranes through its transmembrane peptide (Gray C, Tamm LK, 1997, Protein Sci 6:1993-2006). A distinctive role for the HA1 subunit in the conformational change of HA becomes apparent from these combined studies.
Fast Time-Domain Edge-Diffraction Calculations for Interactive Acoustic Simulations (2006)

The inclusion of edge diffraction has long been recognized as an improvement to geometrical-acoustics (GA) modeling techniques, particularly for acoustic simulations of complex environments that are represented as collections of finite-sized planar surfaces. One particular benefit of combining edge diffraction with GA components is that the resulting total sound field is continuous when an acoustic source or receiver crosses a specular-zone or shadow-zone boundary, despite the discontinuity experienced by the associated GA component. In interactive acoustic simulations which include only GA components, such discontinuities may be heard as clicks or other undesirable audible artifacts, and thus diffraction calculations are important for high perceptual quality as well as physical realism. While exact diffraction calculations are difficult to compute at interactive rates, approximate calculations are possible and sufficient for situations in which the ultimate goal is a perceptually plausible simulation rather than a numerically exact one. In this paper, we describe an edge-subdivision strategy that allows for fast time-domain edge-diffraction calculations with relatively low error when compared with results from a more numerically accurate solution. The tradeoff between computation time and accuracy can be controlled with a number of parameters, allowing the user to choose the speed that is necessary and the error that is tolerable for a specific modeling scenario.
Age-dependent changes in beta-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats (1995)

Epididymal adipocytes were isolated from Fischer 344 rats aged 3, 6, 12, and 24 months, to study the mechanisms responsible for age-dependent diminution in cellular adrenergic responsiveness. Messenger RNA (mRNA) levels for the beta 1-, beta 2-, and beta 3-adrenergic receptors (ARs) were compared across age groups and related to adenylyl cyclase activation by selective receptor agonists in adipocyte plasma membranes and activation of lipolysis in intact cells. mRNA levels for the beta 1-AR decreased by 60% between 3-6 months and remained at this reduced level through 12 and 24 months. A modest increase in beta 2-AR mRNA was noted between 3-12 months, but decreased between 12-24 months to levels seen in the 3-month-old group. mRNA for the beta 3-AR did not change between 3-6 months, but decreased by about 40% between 6-12 months, and by a further 50% between 12-24 months. Lipolytic responsiveness also diminished with age, and regardless of whether beta 3-selective or beta 1/beta 2-selective agonists were used, the maximal release of glycerol was most severely blunted in adipocytes from 24-month-old rats. The age-dependent changes in adenylyl cyclase activation by beta-adrenergic agonists mirrored the observed changes in lipolytic responsiveness with respect to diminished efficacy. These results together with the similar forskolin-stimulated adenylyl cyclase activity among the groups suggest age-dependent changes in activation of adenylyl cyclase at a prior step. This suggestion is also supported by the comparable inhibitory capacities of the alpha 2-adrenergic and A1-adenosine signaling systems among the age groups. In view of the similar levels of Gs alpha, the age-dependent decrease in adrenergic responsiveness in rat adipocytes appears to result primarily from specific decreases in the expression of both beta 3-AR and beta 1-ARs.
Quantum effects influence on thin silicon film capacitor-less DRAM performance (2006)

As DRAM integration follows CMOS interest for thin silicon films, we analyze the impact of quantum effects on capacitor-less DRAM based on floating-body effect. Quantum effects significantly reduce the memory effect when silicon film reaches 10nm but their major impact is for thin and undoped silicon film
Expression of a mutant, full-length form of diphtheria toxin in Escherichia coli (1987)

A mutant, full-length form of diphtheria toxin was cloned into Escherichia coli K-12 and expressed under BL-1 + EK-1 containment. A gene fragment encoding the catalytic domain of the toxin was subjected to oligonucleotide-directed mutagenesis to produce a three-base mutation of an active site residue; Glu-148 was thereby replaced by Ser. Ser-148 fragment A had less than 1% of the ADP-ribosyltransferase activity of wild-type fragment A. Next, the complementary portion of the toxin structural gene was spliced with the mutated DNA fragment downstream of codon 148 to produce a construct that encoded mutant whole toxin with Ser at position 148. The mutant toxin was indistinguishable from authentic diphtheria toxin by Western blot analysis, but was about 800-fold less cytotoxic than wild-type toxin for BS-C-1 cells. Evidence from subunit exchange experiments indicated that a substantial fraction of the mutant toxin contained a fully functional B moiety, capable of mediating the entry of wild-type fragment A into sensitive mammalian cells. This combination of approaches provides a means of applying recombinant DNA methods in E. coli to study structure-function relationships in whole diphtheria toxin.
Aberrant expression of TRAIL in B chronic lymphocytic leukemia (B-CLL) cells (2005)

Analysis of peripheral blood (>85% CD19+/CD5+ B) lymphocytes, obtained from 44 patients affected by B chronic lymphoid leukemia (B-CLL), showed that surface TNF-related apoptosis inducing ligand (TRAIL) was expressed in all samples and at higher levels with respect to unfractionated lymphocytes and purified CD19+ B cells, obtained from 15 normal blood donors. Of note, in a subset of B-CLL samples, the addition to B-CLL cultures of a TRAIL-R1-Fc chimera, which binds at high affinity to surface TRAIL, significantly decreased the percentage of viable cells with respect to untreated control B-CLL cells, suggesting that surface TRAIL may play an unexpected role in promoting B-CLL cell survival. In spite of the majority of B-CLL lymphocytes expressed variable surface levels of "death receptors" TRAIL-R1 and TRAIL-R2, the addition in culture of recombinant TRAIL increased (>20% vs. controls) the degree of spontaneous apoptosis in only 11/44 of the B-CLL samples, had no effect in 19/44, while it significantly increased leukemic cell survival in 14/44. Taken together, these findings suggest that an aberrant expression of TRAIL might contribute to the pathogenesis of B-CLL by promoting the survival in a subset of B-CLL cells.
Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells (1999)

We have demonstrated previously that insulin-like growth factor binding protein (IGFBP)-3 alone has little growth inhibitory effect on Hs578T human breast cancer cells, but that it can dramatically accentuate the apoptotic response to the physiological trigger, ceramide, in an IGF-independent manner. We have now studied the potential of other IGFBPs (1-6) to interact with apoptotic signalling pathways. Hs578T cells were preincubated with a binding protein (100 ng/ml) for 24 h, followed by co-incubation of the binding protein with an apoptotic dose of ceramide or RGD-containing peptide for a further 24 h. Apoptosis was assessed using flow cytometry, MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; thiazolyl blue) assay and morphological assessment. Binding protein profiles were determined using ligand and immunoblotting techniques. Each of the IGFBPs (1-6) alone had no significant (P > 0. 05) growth inhibitory effects relative to control cells. In contrast to IGFBP-3, which significantly (P < 0.05) accentuated C2-induced apoptosis, IGFBP-1, -2, and -6 had no effect, whereas IGFBP-4 and -5 each caused marked (P < 0.01) inhibition of ceramide-induced programmed cell death. Apoptosis induced by RGD was also significantly (P < 0.05) reduced by IGFBP-5, whereas IGFBP-3 had no effect. These data provide evidence to suggest that individual IGFBPs have specific IGF-independent effects and act differentially on apoptotic signalling pathways.
Double-injection flow injection analysis using multivariate calibration for multicomponent analysis (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDouble-injection flow injection analysis using multivariate calibration for multicomponent analysisDavid A. Whitman, Mary Beth. Seasholtz, Gary D. Christian, Jarda. Ruzicka, and Bruce R. KowalskiCite this: Anal. Chem. 1991, 63, 8, 775–781Publication Date (Print):April 15, 1991Publication History Published online1 May 2002Published inissue 15 April 1991https://pubs.acs.org/doi/10.1021/ac00008a008https://doi.org/10.1021/ac00008a008research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Pathways to 2,5‐Dimethylfuran via Biomass‐Derived 5‐(Chloromethyl)furfural (2014)

2,5-Dimethylfuran (DMF) is one of the most actively pursued biomass-derived chemicals due to the fact that it can serve both as a biofuel and an intermediate for drop-in terephthalate polymers. DMF can be accessed via catalytic hydrogenation of 5-(hydroxymethyl)furfural (HMF), but the difficult accessibility of HMF from cellulosic biomass is a major impediment to the commercial development of such a process. Alternatively, 5-(chloromethyl)furfural (CMF) is freely accessible in high yield directly from raw biomass and is shown here to be efficiently reduced to DMF under mild conditions via simple derivatives (aldimine, acetal).
High‐Transconductance Organic Thin‐Film Electrochemical Transistors for Driving Low‐Voltage Red‐Green‐Blue Active Matrix Organic Light‐Emitting Devices (2012)

Abstract Switching and control of efficient red, green, and blue active matrix organic light‐emitting devices (AMOLEDs) by printed organic thin‐film electrochemical transistors (OETs) are demonstrated. These all‐organic pixels are characterized by high luminance at low operating voltages and by extremely small transistor dimensions with respect to the OLED active area. A maximum brightness of ≈900 cd m −2 is achieved at diode supply voltages near 4 V and pixel selector (gate) voltages below 1 V. The ratio of OLED to OET area is greater than 100:1 and the pixels may be switched at rates up to 100 Hz. Essential to this demonstration are the use of a high capacitance electrolyte as the gate dielectric layer in the OETs, which affords extremely large transistor transconductances, and novel graded emissive layer (G‐EML) OLED architectures that exhibit low turn‐on voltages and high luminescence efficiency. Collectively, these results suggest that printed OETs, combined with efficient, low voltage OLEDs, could be employed in the fabrication of flexible full‐color AMOLED displays.
Evaluation of phase and transmittance error on deep-UV halftone phase-shift mask (1996)

The effect of phase shift and transmittance fluctuation in a mask plate have been studied. The differences of these optical properties of halftone phase shift masks result in critical dimension(CD) error on a wafer so that these fluctuation in a plate reduce the process window across the exposure field. In considering CD error budget, such factors as phase shift and transmittance has to be taken into account. To estimate this budget, a set of test masks were fabricated, in which phase shift and transmittance are varied, and the exposures using these masks under the same conditions were performed.
UCF-101: A dataset of 101 human actions classes from videos in the wild (2012)

We introduce UCF101 which is currently the largest dataset of human actions. It consists of 101 action classes, over 13k clips and 27 hours of video data. The database consists of realistic user uploaded videos containing camera motion and cluttered background. Additionally, we provide baseline action recognition results on this new dataset using standard bag of words approach with overall performance of 44.5%. To the best of our knowledge, UCF101 is currently the most challenging dataset of actions due to its large number of classes, large number of clips and also unconstrained nature of such clips.
High density lipoprotein cholesterol and mortality. The Framingham Heart Study. (1988)

In 12 years of follow-up for 2748 Framingham Heart Study participants ages 50 to 79, low levels of high density lipoprotein cholesterol (HDL-C) were associated with increased mortality. For men, the relative risk of death in the first HDL-C quintile (less than 35 mg/dl) as compared to the top quintile (greater than 54 mg/dl) was 1.9 for all causes, and 3.6 and 4.1 for death due to cardiovascular and coronary heart disease (CHD), respectively, after adjustment for standard cardiovascular risk factors. In women, corresponding relative risks, comparing the bottom HDL-C quintile (less than 45 mg/dl) to the top quintile (greater than 69 mg/dl), were 1.5, 1.6, and 3.1. With HDL-C considered as a continuous variable, and after adjustment for standard cardiovascular risk factors, highly significant associations were seen with HDL-C and CHD death in both men and women. In addition, a significant HDL-C effect on total mortality and death due to cardiovascular disease was seen in men. In none of the continuous varia...