gebhart/patrepeval huggingface dataset:
NASD scalable storage systems (1999)

project is to define the next era of storage system interfaces and architectures. To encourage industry standardization of a compliant storage device/subsystem interface, we are working closely with the National Storage Industry Consortium’s working group on network-attached storage. Our experimental demonstration of the NASD interface’s value is device and filesystem prototype software that delivers the scalability inherent in a NASD storage architecture. To engage the academic community and to provide a reference implementation for industry development, CMU is releasing its Linux and Digital UNIX ports of this software. In this paper, we overview the NASD scalable storage architecture and the code-base we are releasing for Linux.
Low-profile circularly polarized radiation elements &#x2014;loops with balanced and unbalanced feeds (2008)

In this paper, the two types of reflector-backed loop antennas have been numerically analyzed. The analyses reveal that a loop with a balanced feed shows a CP wave bandwidth of 15%, which is eight times as wide as that for the other loop with an unbalanced feed, when each loop height above the reflector is 0.25lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> . As the loop height decreases to 0.10lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> , the difference between the bandwidths is found to disappear. These results (for the loop resonant antennas) are compared to those for previous studies on reflector-backed spiral and curl (non-resonant) antennas. It is found that the difference between the CP wave bandwidths for the resonant and non-resonant antennas also disappears, as their antenna heights decrease to 0.10lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> .
Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects (1998)

1. Glucagon-like peptide-1 (7-36) amide (GLP-1) is a gut hormone released postprandially that stimulates insulin secretion, suppresses glucagon secretion and delays gastric emptying. The insulinotropic action of GLP-1 is more potent under hyperglycaemic conditions. Several published studies have indicated the therapeutic potential of subcutaneous GLP-1 in non-insulin-dependent (Type 2) diabetes mellitus. 2. We investigated whether subcutaneous GLP-1, at a dose shown to improve glycaemic control in early Type 2 diabetes, is insulinotropic at normal fasting glucose concentrations. A double-blind, randomized, crossover study of 10 healthy subjects injected with GLP-1 or saline subcutaneously after a 16 h fast was performed. The effect on cardiovascular parameters was also examined. 3. GLP-1 caused a near 5-fold rise in plasma insulin concentration. After treatment with GLP-1, circulating plasma glucose concentrations fell below the normal range in all subjects. One subject had symptoms of hypoglycaemia after GLP-1. A rise in pulse rate was found which correlated with the fall in plasma glucose concentration. An increase in blood pressure occurred with GLP-1 injection which was seen at the same time as the rise in plasma GLP-1 concentrations. 4. This study indicates that subcutaneous GLP-1 can override the normal homoeostatic mechanism maintaining fasting plasma glucose in man, and is also associated with an increase in blood pressure.
A phase I/II study of the hypomethylating agent azacitadine with the nanoparticle albumin bound paclitaxel in the treatment of patients with advanced or metastatic solid tumors. (2011)

3095^ Background: The efficacy of nanoparticle albumin bound paclitaxel (N) seems to correlate with the expression of tumor-associated SPARC. A common mechanism for SPARC downregulation is hypermethylation. This study investigates the use of the hypomethylating agent azacitadine (A), followed by N in the treatment of refractory advanced solid tumors. Methods: Patients with evaluable advanced solid tumors, adequate organ function, PS 0-2, and unlimited prior cytotoxic regimens were eligible. Cohorts of 3-6 patients were enrolled and treated. Escalating doses of A (75-100 mg/m2) was administered to patients SC on days 1-5, followed by a fixed dose of N (100 mg/m2) on days 8, 15, and 22 of a 28-day cycle, for a total of 6 cycles. Serum and/or tissue samples, where appropriate, were collected for correlative studies. Results: Patients were initially permitted to have an unlimited number of prior chemotherapies, but after 2 of the first 5 patients experiencing DLT (grade 4 neutropenia > 8 days), and dose reduction of N occurring in 3 patients all with 4 or more prior cytotoxic regimens, the protocol was amended to permit no more than 2 prior cytotoxic regimens. Cohort 2 was treated at the same dose level (A 75mg/m2) with no DLT. Cohort 3 was treated at the next dose level (A 100 mg/m2). Two of 4 had DLT of prolonged grade 4 neutropenia. Therefore, the MTD of A in this regimen is 75 mg/m2. Three additional patients were treated at the MTD dose with no grade 4 toxicity in cycle 1. To date, 16 patients have enrolled in the phase I part. Two patients were removed before completing cycle 1 because of disease progression. One patient was removed after cycle 4 for noncompliance. Clinical activity included 1 CR in refractory DLBC lymphoma, 2 CR in ovarian cancer, 4PR in ovarian and endometrial cancer, 4 SD in lung, sarcoma and pancreatic cancer, 1 unconfirmed PR in breast cancer, and 1 PD in CLL/SLL. Two breast cancer patients in the phase II part had unconfirmed PR and are still receiving treatments. Conclusions: A 75 mg/m2 followed by weekly N 100 mg/m2 was well tolerated and seemed to result in dramatic responses in heavily pre-treated patients with cancer of diverse histology.
Long-Term Expression of a Fluorescent Reporter Gene via Direct Injection of Plasmid Vector into Mouse Skeletal Muscle: Comparison of Human Creatine Kinase and Cmv Promoter Expression Levels in Vivo (1996)

Expression of a fluorescent reporter gene has been studied using two alternate promoters to transcribe the green fluorescent protein (gfp) from Aequorea victoria. The human cytomegalovirus (CMV) enhancer/promoter or the human muscle-specific creatine kinase promoter (CKM) were inserted along with the gfp cDNA into a plasmid expression vector based on a modified adeno-associated virus genome. Naked plasmid DNA was injected into the hamstring muscle of mdx mice and gfp gene expression determined from frozen muscle sections taken at 4, 14, and 42 days postinjection. Fluorescence patterns obtained by photomicroscopy and quantitative fluorescence measurements indicated a near-linear increase in the accumulation of the gfp in skeletal muscle during the length of the study, with gfp expression at 42 days being roughly four times the values obtained at 4 days. The levels of expression of gfp from the CKM construct were consistantly higher than for the CMV construct. The CKM promoter/expression vector combination demonstrates significant potential for simple, direct delivery and long-term, high-level expression of genes in skeletal muscle.
Unsupervised domain adaptation with multiple acoustic models (2010)

We investigate the problem of adapting a recognition system with multiple acoustic models to a new domain in unsupervised mode. We compare maximum likelihood and discriminative approaches for unsupervised domain adaptation. Different adaptation data selection methods and adaptation strategies are investigated, using a baseline meeting recognition system and adaptation data from a congressional committee web site. Experiments show that one should avoid adapting all acoustic models to the same recognition output, and that ASR confidence estimates improve results when used for rejecting low-quality ASR output. The results show 8% relative overall improvement from unsupervised adaptation.
Kinetic model for the pyrolysis of polysiloxane polymers to ceramic composites (2002)

Abstract A model describing the pyrolysis of an organo‐silicate polymer (Blackglas polymer) to form a silicon oxycarbide glass was developed based on the known chemistry and architecture of the polysiloxane precursor. The objectives were to develop a plausible reaction pathway to explain the pyrolysis process, rate, and product spectrum, and to study the effect of various heating protocols on the pyrolysis process. The model successfully predicted the evolution rates of the major gases as a function of process temperature and the overall pressures reached during the process. The effects of various heating protocols on the outgassing kinetics were studied to develop an optimum protocol for a rapid pyrolysis process that gives a composite with desirable mechanical properties. Overall, the model appears to capture the essential characteristics of the process and is in good agreement with experimental results.
Neuropathology in Rhinosinusitis (2004)

Pathophysiologic differences in neural responses to hypertonic saline (HTS) were investigated in subjects with acute sinusitis (n = 25), subjects with chronic fatigue syndrome (CFS) with nonallergic rhinitis (n = 14), subjects with active allergic rhinitis (AR; n = 17), and normal (n = 20) subjects. Increasing strengths of HTS were sprayed into their nostrils at 5-minute intervals. Sensations of nasal pain, blockage, and drip increased with concentration and were significantly elevated above normal. These parallels suggested activation of similar subsets of afferent neurons. Urea and lysozyme secretion were dose dependent in all groups, suggesting that serous cell exocytosis was one source of urea after neural stimulation. Only AR and normal groups had mucin dose responses and correlations between symptoms and lysozyme secretion (R(2) = 0.12-0.23). The lysozyme dose responses may represent axon responses in these groups. The neurogenic stimulus did not alter albumin (vascular) exudation in any group. Albumin and mucin concentrations were correlated in sinusitis, suggesting that nonneurogenic factors predominated in sinusitis mucous hypersecretion. CFS had neural hypersensitivity (pain) but reduced serous cell secretion. HTS nasal provocations identified significant, unique patterns of neural and mucosal dysregulation in each rhinosinusitis syndrome.
Giant Esophageal Ulcer Treated with Steroids in AIDS Patient (1992)

Elia, Gianfranco; Calzetti, Carlo; Avanzi, Maurizio; Fiaccadori, Franco Author Information
Modification of DNA ends can decrease end joining relative to homologous recombination in mammalian cells. (1987)

In animal cells, exogenous DNA recombines into random chromosomal sites much more frequently than it recombines into homologous sites. Free DNA ends are "recombinogenic" in both processes. To test the effects of specific ends on analogous extrachromosomal processes, we constructed a linear genome of simian virus 40 with terminal repeated sequences. After transfection into monkey cells, the model substrate can circularize by end joining (analogous to random integration) or by homologous recombination between its terminal repeats (analogous to targeted recombination). Since the two types of recombination are in competition with one another, the ratio of homologous-recombination to end-join products is a sensitive indicator of the differential effects of specific ends. Substrates with blunt ends, complementary sticky ends, or mismatched ends generated the same ratio of homologous-recombination to end-join products. However, addition of dideoxynucleotides to the 3' hydroxyls of the substrate decreased the frequency of end joining by a factor of 5-6 relative to homologous recombination. Thus, the frequency of end joining can be decreased relative to that of homologous recombination by modification of the ends of the input DNA. These results suggest an approach to altering the ratio of random to targeted integration in mammalian cells.
Wetting Behavior of Porous Silicon Surfaces Functionalized with a Fulleropyrrolidine (2006)

We report the immobilization of a fulleropyrrolidine, bearing a dec-9-ynyl functionality, on silicon surfaces through a thermal hydrosilylation protocol. Contact angle measurements on porous silicon (PS) surfaces reveal an unusual dependence of the angle with the PS roughness that apparently contradicts Wenzel's formula. This result has been explained by an extension of Wenzel's model in which the critical angle, which discriminates between the hydrophilic/hydrophobic character of a solid material, is substantially reduced below 90 degrees by surface roughness.
The facility of formation of a .DELTA.6 bond in dihydromorphinone and related opiates (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe facility of formation of a .DELTA.6 bond in dihydromorphinone and related opiatesHiroshi Nagase, Akira Abe, and Philip S. PortogheseCite this: J. Org. Chem. 1989, 54, 17, 4120–4125Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00278a025https://doi.org/10.1021/jo00278a025research-articleACS PublicationsRequest reuse permissionsArticle Views461Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Crystal Growth Kinetics and Viscous Behavior in Ge2Sb2Se5 Undercooled Melt (2016)

Crystal growth, viscosity, and melting were studied in Ge2Sb2Se5 bulk samples. The crystals formed a compact layer on the surface of the sample and then continued to grow from the surface to the central part of the sample. The formed crystalline layer grew linearly with time, which suggests that the crystal growth is controlled by liquid-crystal interface kinetics. Combining the growth data with the measured viscosities and melting data, crystal growth could be described on the basis of standard crystal growth models. The screw dislocation growth model seems to be operative in describing the temperature dependence of the crystal growth rate in the studied material in a wide temperature range. A detailed discussion on the relation between the kinetic coefficient of crystal growth and viscosity (ukin ∝ η(-ξ)) is presented. The activation energy of crystal growth was found to be higher than the activation energy of crystallization obtained from differential scanning calorimetry, which covers the whole nucleation-growth process. This difference is considered and explained under the experimental conditions.
Quantum circuit learning (2018)

We propose a classical-quantum hybrid algorithm for machine learning on near-term quantum processors, which we call quantum circuit learning. A quantum circuit driven by our framework learns a given task by tuning parameters implemented on it. The iterative optimization of the parameters allows us to circumvent the high-depth circuit. Theoretical investigation shows that a quantum circuit can approximate nonlinear functions, which is further confirmed by numerical simulations. Hybridizing a low-depth quantum circuit and a classical computer for machine learning, the proposed framework paves the way toward applications of near-term quantum devices for quantum machine learning.
‘Green’ derivatization of carbon nanotubes with Nylon 6 andl-alanine (2006)

Amide derivatives of L-alanine and ε-caprolactam were readily obtained on diamine-functionalized oxidized single-walled and pristine multi-walled carbon nanotubes through a one-step direct amidation reaction, which employs thermal activation at 160–200 °C instead of chemical activation, avoids the use of organic solvents, and requires a few hours only for completion. In the case of ε-caprolactam, amino groups attached to the nanotubes initiated polymerization into Nylon 6. The functionalized nanotubes were characterized by infrared and Raman spectroscopy, scanning and transmission electron microscopy, atomic force microscopy, thermal gravimetric analysis and differential scanning calorimetry.
Aluminum citrate: isolation and structural characterization of a stable trinuclear complex (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAluminum citrate: isolation and structural characterization of a stable trinuclear complexTimothy L. Feng, Patrick L. Gurian, Matthew D. Healy, and Andrew R. BarronCite this: Inorg. Chem. 1990, 29, 3, 408–411Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ic00328a013https://doi.org/10.1021/ic00328a013research-articleACS PublicationsRequest reuse permissionsArticle Views980Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cell Labeling via Membrane-Anchored Lipophilic MR Contrast Agents (2014)

Cell tracking in vivo with MR imaging requires the development of contrast agents with increased sensitivity that effectively label and are retained by cells. Most clinically approved Gd(III)-based contrast agents require high incubation concentrations and prolonged incubation times for cellular internalization. Strategies to increase contrast agent permeability have included conjugating Gd(III) complexes to cell penetrating peptides, nanoparticles, and small molecules which have greatly improved cell labeling but have not resulted in improved cellular retention. To overcome these challenges, we have synthesized a series of lipophilic Gd(III)-based MR contrast agents that label cell membranes in vitro. Two of the agents were synthesized with a multiplexing strategy to contain three Gd(III) chelates (1 and 2) while the third contains a single Gd(III) chelate (3). These new agents exhibit significantly enhanced labeling and retention in HeLa and MDA-MB-231-mcherry cells compared to agents that are internalized by cells (4 and Prohance).
Two neonatal cholestasis patients with mutations in the SRD5B1 (AKR1D1) gene: diagnosis and bile acid profiles during chenodeoxycholic acid treatment (2012)

Primary bile acid treatment using chenodeoxycholic acid was effective for these patients treated in early infancy before the late stage of chronic cholestatic liver dysfunction.
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice (2009)

Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis, angiogenesis, and metastasis. However, the mechanisms by which they regulate these processes remain unknown. As the cell surface serine protease fibroblast activation protein (FAP) is selectively expressed on tumor-associated fibroblasts and pericytes in epithelial tumors, we set out to investigate the role of FAP in mouse models of epithelial-derived solid tumors. In this study, we demonstrate that genetic deletion and pharmacologic inhibition of FAP inhibited tumor growth in both an endogenous mouse model of lung cancer driven by the K-rasG12D mutant and a mouse model of colon cancer, in which CT26 mouse colon cancer cells were transplanted into immune competent syngeneic mice. Interestingly, growth of only the K-rasG12D-driven lung tumors was also attenuated by inhibition of the closely related protease dipeptidyl peptidase IV (DPPIV). Our results indicate that FAP depletion inhibits tumor cell proliferation indirectly, increases accumulation of collagen, decreases myofibroblast content, and decreases blood vessel density in tumors. These data provide proof of principle that targeting stromal cell-mediated modifications of the tumor microenvironment may be an effective approach to treating epithelial-derived solid tumors.
Reactivation of Hippocampal Ensemble Memories During Sleep (1994)

Simultaneous recordings were made from large ensembles of hippocampal "place cells" in three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors. Cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks. Cells that were inactive during behavior, or that were active but had non-overlapping spatial firing, did not show this increase. This effect, which declined gradually during each post-behavior sleep session, may result from synaptic modification during waking experience. Information acquired during active behavior is thus re-expressed in hippocampal circuits during sleep, as postulated by some theories of memory consolidation.
Amide protection and amide supports in solid-phase peptide synthesis (1970)

A protecting group for side-chain amide functions, and polymeric amino-supports for use in the synthesis of C-terminal amide peptides, have been developed, and their use demonstrated in the syntheses of gastrin tetrapeptide by the solution and the solid-phase procedures.