gebhart/patrepeval huggingface dataset:
Improving Turbo Codec Integration in Pixel-Domain Distributed Video Coding (2006)

The field of distributed video coding (DVC) theory has received a lot of attention in recent years and effective encoding techniques have been proposed. In the present work the framework of pixel domain Wyner-Ziv coding of video frames is considered, following the scheme proposed in A. Aaron et al. (2002). Some key frames are supposed to be available at the decoder while other frames are Wyner-Ziv encoded using turbo codes; at the decoder motion compensated interpolation between the key frames is performed in order to construct the side information for the Wyner-Ziv frame decoding. In this paper an improved model for the correlation noise between the side information frame and the original one is proposed. It is shown that modeling the nonstationary nature of the noise leads to substantial gain in the rate-distortion performance. Furthermore, by considering the memory of the noise, we show that some further gain can be obtained by placing an interleaver before the turbo codec so as to spread the correlation noise all over the frame
Optimizing correctly-rounded reciprocal square roots for embedded VLIW cores (2009)

This paper presents an optimized software implementation of the reciprocal square root function x ¿ x <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1/2</sup> , for IEEE binary32 floating-point data and with correct rounding to nearest. The main feature of this implementation is high instruction-level parallelism (ILP) exposure, which results here from an extension of the bivariate polynomial evaluation-based method of as well as from the design of a specific rounding procedure. This implementation proves to be very efficient for some VLIW processor cores like STMicroelectronics' ST231 (used mainly for embedded media processing), for which a low latency of 29 cycles has been measured.
The TRANSPARENT TESTA12 Gene of Arabidopsis Encodes a Multidrug Secondary Transporter-Like Protein Required for Flavonoid Sequestration in Vacuoles of the Seed Coat Endothelium (2001)

Isabelle Debeaujon, Anton J. M. Peeters, , Maarten Koornneef, The TRANSPARENT TESTA12 Gene of Arabidopsis Encodes a Multidrug Secondary Transporter-Like Protein Required for Flavonoid Sequestration in Vacuoles of the Seed Coat Endothelium, The Plant Cell, Vol. 13, No. 4 (Apr., 2001), pp. 853-871
Signal separation by symmetric adaptive decorrelation: stability, convergence, and uniqueness (1995)

The performance of signal enhancement systems based on adaptive filtering is highly dependent on the quality of the noise reference. In the LMS algorithm, signal leakage into the noise reference leads to signal distortion and poor noise cancellation. The origin of the problem lies in the fact that LMS decorrelates the signal estimate with the noise reference, which, in the case of signal leakage, makes little sense. An algorithm is proposed that decorrelates the signal estimate with a "signal-free" noise estimate, obtained by adding a symmetric filter to the classical structure. The symmetric adaptive decorrelation (SAD) algorithm no longer makes a distinction between signal and noise and is therefore a signal separator rather than a noise canceler. Stability and convergence are of the utmost importance in adaptive algorithms and hence are carefully studied. Apart from limitations on the adaptation constants, stability around the desired solution can only be guaranteed for a subclass of signal mixtures. Furthermore, the decorrelation criterion does not yield a unique solution, and expressions for the "phantom" solutions are derived. Simulations with short FIR filters confirm the predicted behavior.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A fast and efficient microfluidic system for highly selective one-to-one droplet fusion (2009)

Microdroplets in microfluidic systems can be used as independent microreactors to perform a range of chemical and biological reactions. However, in order to add new reagents to pre-formed droplets at defined times, to start, modify, or terminate a reaction, it is necessary to perform a controlled fusion with a second droplet. We describe and characterize a simple and extremely reliable technique for the one-to-one fusion of droplet pairs in a microfluidic system at kHz frequencies. The technique does not require special channel treatment, electrical fields or lasers to induce droplet fusion. Instead, we make use of transient states in the stabilization of the droplet interface by surfactant, coupled to a proper geometrical design of a coalescence module, to induce the selective fusion of a droplet stabilized by surfactant (re-injected) with a droplet which is not fully stabilized (generated on-chip). Using a 1.2-fold excess of the surfactant-stabilized droplets approximately 99% of the partially stabilized droplets were fused one-to-one with surfactant-stabilized droplets. Even when the surfactant-stablized droplets were in 5-fold excess, over 96% of the partially stabilized droplets were fused one-to-one. The fused droplet contains enough surfactant to inhibit further fusion events. After fusion, the droplets were fully stabilized by additional surfactant provided in the carrier oil, which allowed the fused droplets to be collected, incubated off-chip and re-injected onto a microfluidic device without any undesired coalescence.
An Agonist Murine Monoclonal Antibody to the Human c-Mpl Receptor Stimulates Megakaryocytopoiesis (1998)

Thrombopoietin (TPO) is a hematopoietic growth factor that stimulates megakaryocytopoiesis and platelet production in vivo and promotes the development of identifiable megakaryocytes in vitro. We have developed a murine monoclonal antibody, BAH-1, raised against human megakaryocytic cells, which specifically recognizes the c-Mpl receptor and shows agonist activity by stimulating megakaryocytopoiesis in vitro. BAH-1 antibody specifically binds to platelets and to recombinant c-Mpl with high affinity. Similar to TPO, BAH-1 alone supported the formation of colony-forming unit-megakaryocyte (CFU-MK) colonies. The combination of BAH-1 plus interleukin-3 or of BAH-1 plus human TPO significantly increased the number of human CFU-MK colonies. In addition, BAH-1 monoclonal antibody stimulated the proliferation and maturation of primary bone marrow megakaryocytes in a dynamic heterogeneous liquid culture system. Individual large megakaryocytes as well as small megakaryocytic cells were observed in cultures of CD34+ CD41+cells in the presence of BAH-1 antibodies. Similar to TPO, BAH-1 antibody induced a significant response of murine immature megakaryocytes as observed by an increase in the detectable numbers of acetylcholinesterase-positive megakaryocytes. No effects of BAH-1 antibody were observed on colony-forming unit–granulocyte-macrophage, burst-forming unit-erythroid, or colony-forming unit-erythroid colonies. In vivo studies showed that BAH-1, alone or in combination with TPO, expands the numbers of megakaryocytic progenitor cells in myelosuppressed mice. This antibody should prove useful in understanding the structure-function aspects of the c-Mpl receptor as well as in evaluating the effects of the sustained activation of this receptor in preclinical models of severe thrombocytopenia. © 1998 by The American Society of Hematology.
IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection (2003)

West Nile (WN) virus causes fatal meningoencephalitis in laboratory mice, thereby partially mimicking human disease. Using this model, we have demonstrated that mice deficient in gammadelta T cells are more susceptible to WN virus infection. TCRdelta(-/-) mice have elevated viral loads and greater dissemination of the pathogen to the CNS. In wild-type mice, gammadelta T cells expanded significantly during WN virus infection, produced IFN-gamma in ex vivo assays, and enhanced perforin expression by splenic T cells. Adoptive transfer of gammadelta T cells to TCRdelta(-/-) mice reduced the susceptibility of these mice to WN virus, and this effect was primarily due to IFN-gamma-producing gammadelta T cells. These data demonstrate a distinct role for gammadelta T cells in the control of and prevention of mortality from murine WN virus infection.
The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis (2011)

Constitutive germ cell apoptosis during mammalian spermatogenesis is a key process for controlling sperm output and to eliminate damaged or unwanted cells. An increase or decrease in the apoptosis rate has deleterious consequences and leads to low sperm production. Apoptosis in spermatogenesis has been widely studied, but the mechanism by which it is induced under physiological or pathological conditions has not been clarified. We have recently identified the metalloprotease ADAM17 (TACE) as a putative physiological inducer of germ cell apoptosis. The mechanisms involved in regulating the shedding of the ADAM17 extracellular domain are still far from being understood, although they are important in order to understand cell-cell communications. Here, we review the available data regarding apoptosis during mammalian spermatogenesis and the localization of ADAM proteins in the male reproductive tract. We propose an integrative working model where ADAM17, p38 MAPK, protein kinase C (PKC) and the tyrosine kinase c-Abl participate in the physiological signalling cascade inducing apoptosis in germ cells. In our model, we also propose a role for the Sertoli cell in regulating the Fas/FasL system in order to induce the extrinsic pathway of apoptosis in germ cells. This working model could be applied to further understand constitutive apoptosis in spermatogenesis and in pathological conditions (e.g., varicocele) or following environmental toxicants exposure (e.g., genotoxicity or xenoestrogens).
Ultrasonic speckle pattern correlation interferometry using a pulse-echo method (1998)

An experimental study of the ultrasonic speckle pattern correlation interferometry is presented. To obtain the ultrasonic speckle interferograms, we have used a simple experimental set-up of the interferometer. Ultrasonic speckle patterns are shown in the C-scan images which are composed of B scans with sub-millimetre scanning steps. Using this set-up, we were able to obtain the speckle interferograms of known deformations.
Phonons in carbon nanotubes (2000)

A broad review of the unusual one-dimensional properties of phonons in carbon nanotubes is presented, including phonons in isolated nanotubes and in crystalline arrays of nanotubes in nanotube bundles. The main technique for probing the phonon spectra has been Raman spectroscopy and the many unique and unusual features of the Raman spectra of carbon nanotubes are reviewed. Also included is a brief review of the thermal properties of carbon nanotubes in relation to their unusual phonon dispersion relations and density of states.
Reproductive Endocrine Considerations and Hormonal Therapy for Men with Epilepsy (1991)

Androgen deficiency is unusually common among men with epilepsy. It may contribute to reproductive and sexual dysfunction and possibly exacerbate seizure frequency. The most important androgen is testosterone. it exists in the serum in a free form or bound to albumin or sex hormone-binding globulin (SHBG). Free testosterone levels have correlated significantly with measures of potency and sexual interest. The possibility that measures of non-SHBG-bound testosterone may provide a more sensitive assessment of biologically and perhaps clinically significant androgen levels is raised for consideration. Androgen deficiency may result from increased catabolism and binding induced by antiepileptic drugs (AEDs). It is a feature of the reproductive endocrine disorders that are often associated with epilepsy: hypogonadotropic hypogonadism, hypergonadotropic hypogonadism, and functional hyperprolactinemia. It may be a consequence of medication-induced elevations in serum estradiol. Estradiol exerts a potent inhibitory influence on luteinizing hormone secretion and may contribute to premature aging of the reproductive system, both at the level of the testes and the hypothalamus. Testosterone therapy may moderately benefit reproductive and sexual function. Despite its antiseizure effects in animal experiments, however, it has not been reported to improve seizures clinically. One possible explanation is that AEDs that induce enzyme synthesis may enhance the conversion of testosterone to estradiol by aromatase. This possibility is supported by the improved seizure control achieved with the adjunctive use of the aromatase inhibitor testolactone or the antiestrogen clomiphene.
The Unreliability of MTT Assay in the Cytotoxic Test of Primary Cultured Glioblastoma Cells (2015)

MTT assay is commonly used to assess the cellular cytotoxicity caused by anticancer drugs in glioblastomas. However, there have been some reports insisting that MTT assay exhibited non-specific intracellular reduction of tetrazolium which led to underestimated results of cytotoxicity. Here, we examine whether or not MTT assay can lead to incorrect information regarding alcohol-induced cytotoxicity on immortalized and primary glioblastoma cells. MTT assay was applied to assess the ethanol-induced cytotoxicity at various ethanol concentrations. The cellular cytotoxicity induced by different doses of ethanol was analyzed and compared through several cytotoxic assays. Ethanol-induced cytotoxicity observed through MTT assay on both cell types was shown to be ethanol dose-dependent below a 3% concentration. However, the cytotoxicity was shown to be markedly underestimated only in primary cells at a 5% concentration. RT-PCR and Western Blot showed increased expressions of pro-apoptotic proteins and decreased expressions of anti-apoptotic proteins in an ethanol dose-dependent manner in both cell types. Furthermore, we present a possible mechanism for the unreliable result of MTT assay. A high concentration of ethanol induces more severe membrane damage and increased intracellular concentration of NADH in primary cells which enhances the nonspecific reduction of tetrazolium salt. Together, our findings demonstrate that the cytotoxicity on primary cells could inaccurately be assessed when detected through MTT assay. Therefore, a careful interpretation is needed when one would analyze the cytotoxic results of MTT assay, and it is suggested that other assays must be accompanied to produce more reliable and accurate cytotoxic results on primary glioblastoma cells.
Derivation of orthogonal leads from the 12-lead ECG. accuracy of a single transform for the derivation of atrial and ventricular waves (2006)

Vectorcardiograms are not usually recorded in clinical practice and must be derived from the conventional 12- lead ECG, for example by making use of Dower's transform. However, its accuracy for the derivation of the P wave is questionable. We tested the accuracy of Dower's transform on the P-wave and compared with a P-wave optimized transform in a database of 123 simultaneous recordings of ECGs and VCGs. This new transform achieved a lower error when we compared derived vs. true measured P-waves (12.2 plusmn 7.96 muVRMS) than Dower's transform (14.4 plusmn 9.5 muVRMS) and higher correlation values (Rx = 0.93 plusmn 0.12, Ry = 0.90 plusmn 0.27, Rz = 0.91 plusmn0.18 vs. Dower's: Rx = 0.88 plusmn 0.15, Ry = 0.91 plusmn 0.26 , Rz = 0.85 plusmn 0.23). We concluded that derivation of P-waves and QRS complexes VCGs were optimized by the use of different transform matrices for each wave in this database.
Ligand Design for Electrochemically Controlling Stoichiometric and Catalytic Reactivity of Transition Metals (1998)

Changing the oxidation state of redox-active ligands is a powerful method for electrochemically controlling the reactivity and selectivity of bound transition metals (see drawing on the right). In some cases reaction rates can be increased by many orders of magnitude simply by removing an electron from a metal-ligand complex. In the case of polymeric redox-active ligands, a continuous range of properties can be achieved for the transition metal complex.
Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury (2014)

Perinatal ischemic brain injury can occur as a result of a global ischemic insult or focal ischemic stroke in the preterm or full-term neonate. One of the most striking features of HI injury is that, after initial recovery of cellular oxidative metabolism, there is a delayed, 'secondary' mitochondrial failure that spreads over time from the most severely damaged areas outwards, into previously undamaged regions. This secondary failure is accompanied by transient seizure activity and cytotoxic edema. The specific mechanisms of this spread are poorly understood, but it is at least partly associated with spreading waves of depression that can trigger cell death in neighboring uninjured tissues. Both Connexin and Pannexin hemichannels may mediate release of paracrine molecules that in turn propagate cell death messages by releasing intracellular mediators, such as ATP, NAD(+), or glutamate or by abnormally prolonged opening to allow cell edema. This review will discuss the controversy around the relative contribution of both Connexin and Pannexin hemichannels and mechanisms by which they may contribute to the spread of ischemic brain injury.
Clinical Uses of Melatonin: Evaluation of Human Trials (2010)

During the last 20 years, numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine. The objective of this article is to review, in depth, the science regarding clinical trials performed to date. The efficacy of melatonin has been assessed as a treatment of ocular diseases, blood diseases, gastrointestinal tract diseases, cardiovascular diseases, diabetes, rheumatoid arthritis, fibromyalgia, chronic fatigue syndrome, infectious diseases, neurological diseases, sleep disturbances, aging and depression. Melatonin has been also used as a complementary treatment in anaesthesia, hemodialysis, in vitro fertilization and neonatal care. The conclusion of the current review is that the use of melatonin as an adjuvant therapy seems to be well funded for macular degeneration, glaucoma, protection of the gastric mucosa, irritable bowel syndrome, arterial hypertension, diabetes, side effects of chemotherapy and radiation in cancer patients or hemodialysis in patients with renal insufficiency and, especially, for sleep disorders of circadian etiology (jet lag, delayed sleep phase syndrome, sleep deterioration associated with aging, etc.) as well as in those related with neurological degenerative diseases (Alzheimer, etc.,) or Smith-Magenis syndrome. The utility of melatonin in anesthetic procedures has been also confirmed. More clinical studies are required to clarify whether, as the preliminary data suggest, melatonin is useful for treatment of fibromyalgia, chronic fatigue syndrome, infectious diseases, neoplasias or neonatal care. Preliminary data regarding the utility of melatonin in the treatment of ulcerative colitis, Crohn's disease, rheumatoid arthritis are either ambiguous or negative. Although in a few cases melatonin seems to aggravate some conditions, the vast majority of studies document the very low toxicity of melatonin over a wide range of doses.
Peginterferon Alfa-2a in Patients with Chronic Hepatitis C (2000)

In patients with chronic hepatitis C, a regimen of peginterferon alfa-2a given once weekly is more effective than a regimen of interferon alfa-2a given three times weekly.
Synthesis of Organic Monolayer-Stabilized Copper Nanocrystals in Supercritical Water (2001)

When water is heated and pressurized above the critical point, it becomes a suitable solvent to employ organic capping ligands to control and stabilize the synthesis of nanocrystals. Without alkanethiol ligands, Cu(NO3)2 hydrolyzes to form polydisperse copper(II) oxide particles with diameters from 10 to 35 nm. However, in the presence of 1-hexanethiol, X-ray photoelectron spectroscopy, selected area electron diffraction, and transmission electron microscopy reveal the formation of copper nanocrystals ∼7 nm in diameter. The use of a different precursor, Cu(CH3COO)2, leads to particles with significantly different morphologies. A mechanism is proposed for sterically stabilized nanocrystal growth in supercritical water that describes competing pathways of hydrolysis to large oxidized copper particles versus ligand exchange and arrested growth by thiols to produce small monodisperse Cu nanoparticles.
Alterations in insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis in transformed osteoblastic cells (1995)

Insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) is secreted by a variety of osteoblastic cells and appears to be an integral component of bone cell physiology. We have previously reported that normal human osteoblast-like (hOB) cells secrete IGFBP-4 as well as a novel IGFBP-4 protease, which requires IGF for functional activity. In this study we assessed the IGFBP-4/IGFBP-4 protease system in transformed osteoblastic cells by Western ligand blotting and cell-free IGFBP-4 protease assays. Simian virus-40-immortalized hOB cells (HOBIT), human osteosarcoma cells (TE-85), and rat osteosarcoma cells (UMR 106-01, ROS 17/2.8) secrete IGFBP-4. In contrast to the rapid and dramatic proteolysis in hOB medium, medium conditioned by these cells had no apparent IGFBP-4 protease activity when assayed with exogenous IGF-II in culture or under cell-free conditions. Assayed in the presence of exogenous protease. HOBIT cells, but not the osteosarcoma cell lines, appeared to produce a cycloheximide-sensitive inhibitor of the IGFBP-4 proteolytic reaction. Transient cell transformation induced by incubating human osteoblasts transfected with a temperature-sensitive mutant of simian virus-40 T-antigen at the permissive temperature or by treating hOB cells with phorbol ester tumor promoters also resulted in inhibition of IGF-dependent IGFBP-4 proteolysis. Inhibition was observed if phorbol ester was added to the cultures at the time of medium change or after the protease had been expressed and secreted. Differences in IGFBP-4 proteolysis could not be accounted for by changes in IGFBP-4 messenger RNA expression or substrate levels. These data suggest that transformation is associated with alterations in the IGFBP-4/IGFBP-4 protease system in osteoblastic cells. Normal human osteoblasts secrete an IGF-dependent IGFBP-4 protease. The induction of an inhibitor of the IGF-dependent IGFBP-4 proteolytic reaction may be associated with early transformation processes. Fully tumorigenic bone cells expressed neither IGFBP-4 protease nor protease inhibitor activity.
On an Adaptive Filter Based on Forecast Errors Modelling for Data Assimilation and Its Comparison with Optimal Interpolation Method (2006)

A technique, closely related to the breeding method, is described for sim-ulating prediction errors for components of the system state which is very simple to implement and requires only some in-tegrations of the numerical model. This technique is proposed for approximat-ing forecast errors covariance matrices (ECM) participating in construction of the lter gain which is a central prob-lem in application of the adaptive lter-ing algorithm [1]. Very high performance of a new lter will be demonstrated for SSH data assimilation experiment with the oceanic model MICOM.