gebhart/patrepeval huggingface dataset:
Ethnic Minorities Development Plan (EMDP) (revised) (2001)

This is an environmental assessment of the Sustainable Forestry Development Project, which supports protected areas management, natural forest management, and the establishes wood plantations and tree orchards. Negative environmental and social impacts and their mitigations are addressed. The risk of serious social risks will be minimized by setting up conflict resolution and appeal mechanisms; and establishing principles and procedures for awarding fair compensation for involuntary loss of land. The possibility of friction between participating villages and non-participating villages in and adjacent to nature reserves has been raised in the social assessment. Initial assistance will be given to those communities most affected by management programs or, conversely, those who have the most direct impact on natural resources within the nature reserve. To avoid conflicts, decisions will be transparent and the reasons explained to all interested communities. Planning services and community conservation funding may be extended in time to other priority communities according to understood selection criteria. To reduce the susceptibility of horticultural crops to insect and microbiological attack and the concomitant excess use of pesticides, fungicides, etc., a diversity of crops will be offered; crop selection will consider farmer preferences, site conditions and market prospects; farmer training and extension services will be provided; and a pest management plan supported.
On the question of a subdural space (1991)

The structure of the meninges, with particular attention to the architecture of the inner portions of the dura mater and the arachnoid mater, has been reviewed in reference to the probable existence of a "subdural" space. The dura is composed of fibroblasts and large amounts of extracellular collagen. The innermost part of the dura is formed by the dural border cell layer. This layer is characterized by flattened cells with sinuous processes, extracellular spaces containing an amorphous material, and the presence of junctions between its cells. The dural border cell layer is continuous with the inner (meningeal) portions of the dura and may be attached to the underlying arachnoid by an occasional cell junction. The arachnoid consists of an outer part, the arachnoid barrier cell layer, and an inner portion, the arachnoid trabeculae which bridge the subarachnoid space. Arachnoid barrier cells are electron-lucent, closely apposed to each other, and joined by many cell junctions; in this layer there is little extracellular space and essentially no intercellular material. Arachnoid trabecular cells cross the subarachnoid space in a random manner, have extracellular collagen associated with their flattened processes, and form structures of variable shapes and sizes. There is no evidence of an intervening space between the arachnoid barrier cell layer and the dural border cell layer that would correlate with what has been called the subdural space. When a tissue space is created in this general area of the meninges it is the result of tissue damage and represents, in most instances, a cleaving open of the dural border cell layer. In this situation, extracellular spaces in the dural border cell layer are enlarged, cell junctions are separated, and it is probable that cell membranes are damaged. A survey of reports describing the morphology of the inner and outer capsule of so-called subdural hematomas in humans reveals that dural border cells are found in both parts of the capsule. Also, experimental infusion of blood into this portion of the meninges in animals frequently dissects open the dural border cell layer. These data support the view that what has been called a subdural hematoma is most frequently a lesion found within the layer formed by dural border cells. It is suggested that the so-called subdural space is not a "potential" space since the creation of a cleft in this area of the meninges is the result of tissue damage. In this respect it shares no similarities with legitimate potential spaces (i.e., serous cavities) found at other locations in the body.(ABSTRACT TRUNCATED AT 400 WORDS)
Repeated consensus sequence and pseudopromoters in the four coordinately regulated tubulin genes of Chlamydomonas reinhardi. (1984)

The 5' coding and promoter regions of the four coordinately regulated tubulin genes of Chlamydomonas reinhardi have been mapped and sequenced. DNA sequencing data shows that the predicted N-terminal amino acid sequences of Chlamydomonas alpha- and beta-tubulins closely match that of tubulins of other eucaryotes. Within the alpha 1- and alpha 2-tubulin gene set and the beta 1- and beta 2-tubulin gene set, both nucleotide sequence and intron placement are highly conserved. Transcription initiation sites have been located by primer extension analysis at 140, 141, 159, and 132 base pairs upstream of the translation initiator codon for the alpha 1-, alpha 2-, beta 1-, and beta 2-tubulin genes, respectively. Among the structures with potential regulatory significance, the most striking is a 16-base-pair consensus sequence [GCTC(G/C)AAGGC(G/T)(G/C)--(C/A)(C/A)G] which is found in multiple copies immediately upstream of the TATA box in each of the four genes. An unexpected discovery is the presence of pseudopromoter regions in two of the transcribed tubulin genes. One pseudopromoter region is located 400 base pairs upstream of the authentic alpha 2-tubulin gene promoter, whereas the other is located within the transcribed 5' noncoding region of the beta 1-tubulin gene.
Expressive expression mapping with ratio images (2001)

Facial expressions exhibit not only facial feature motions, but also subtle changes in illumination and appearance (e.g., facial creases and wrinkles). These details are important visual cues, but they are difficult to synthesize. Traditional expression mapping techniques consider feature motions while the details in illumination changes are ignored. In this paper, we present a novel technique for facial expression mapping. We capture the illumination change of one person's expression in what we call an expression ratio image (ERI). Together with geometric warping, we map an ERI to any other person's face image to generate more expressive facial expressions.
What is the functional role of the thalidomide binding protein cereblon? (2011)

It has been found that nonsense mutation R419X of cereblon (CRBN) is associated with autosomal recessive non-syndromic mental retardation. Further experiments showed that CRBN binds to the cytosolic C-terminus of large-conductance Ca(++) activated potassium channel (BK(Ca)) α-subunit and the cytosolic C-terminus of a voltage-gated chloride channel-2 (ClC-2), suggesting that CRBN may play a role in memory and learning via regulating the assembly and surface expression of BK(Ca) and ClC-2 channels. In addition, it has also been found that CRBN directly interacts with the α1 subunit of AMP-activated protein kinase (AMPK) and prevents formation of a functional holoenzyme with regulatory subunits β and γ. Since AMPK is a master sensor of energy balance that inhibits ATP-consuming anabolic pathways and increases ATP-producing catabolic pathways, binding of CRBN with α1 subunit of AMPK may play a role in these pathways by regulating the function of AMPK. Furthermore, CRBN interacts with damaged DNA binding protein 1 and forms an E3 ubiquitin ligase complex with Cullin 4 where it functions as a substrate receptor in which the proteins recognized by CRBN might be ubiquitinated and degraded by proteasomes. Proteasome-mediated degradation of unneeded or damaged proteins plays a very important role in maintaining regular function of a cell, such as cell survival, dividing, proliferation and growth. Intriguingly, a new role for CRBN has been identified, i.e, the binding of immunomodulatory drugs (IMiDs), e.g. thalidomide, to CRBN has now been associated with teratogenicity and also the cytotoxicity of IMiDs, including lenalidomide, which are widely used to treat multiple myeloma patients. CRBN likely plays an important role in binding, ubiquitination and degradation of factors involved in maintaining function of myeloma cells. These new findings regarding the role of CRBN in IMiD action will stimulate intense investigation of CRBN's downstream factors involved in maintaining regular function of a cell.
(R,R)-1,3-Dibenzylisoindoline: a new C2-symmetric secondary amine, by stereoselective and regioselective .alpha.,.alpha.'-dialkylation of isoindoline, and an improved procedure for the preparation of isoindoline (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(R,R)-1,3-Dibenzylisoindoline: a new C2-symmetric secondary amine, by stereoselective and regioselective .alpha.,.alpha.'-dialkylation of isoindoline, and an improved procedure for the preparation of isoindolineRobert E. Gawley, Sanjay R. Chemburkar, Arthur L. Smith, and Tarakeshwar V. AnklekarCite this: J. Org. Chem. 1988, 53, 22, 5381–5383Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/jo00257a041https://doi.org/10.1021/jo00257a041research-articleACS PublicationsRequest reuse permissionsArticle Views1574Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice (2005)

The enzyme 11beta-hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11beta-HSD1 has a therapeutic effect in mouse models of metabolic syndrome. Administration of a selective, potent 11beta-HSD1 inhibitor lowered body weight, insulin, fasting glucose, triglycerides, and cholesterol in diet-induced obese mice and lowered fasting glucose, insulin, glucagon, triglycerides, and free fatty acids, as well as improved glucose tolerance, in a mouse model of type 2 diabetes. Most importantly, inhibition of 11beta-HSD1 slowed plaque progression in a murine model of atherosclerosis, the key clinical sequela of metabolic syndrome. Mice with a targeted deletion of apolipoprotein E exhibited 84% less accumulation of aortic total cholesterol, as well as lower serum cholesterol and triglycerides, when treated with an 11beta-HSD1 inhibitor. These data provide the first evidence that pharmacologic inhibition of intracellular GC activation can effectively treat atherosclerosis, the key clinical consequence of metabolic syndrome, in addition to its salutary effect on multiple aspects of the metabolic syndrome itself.
Phosphate binders and management of hyperphosphataemia in end-stage renal disease (2006)

Keywords: hyperphosphataemia; phosphate binders;renal failure; vascular calcificationsHyperphosphataemia is a known factor contributingto the increased risk of cardiac death both in patientswith end-stage renal disease (ESRD) and in thoseunder renal replacement treatment with dialysis [1,2].In patients with renal disease, in fact, the well-knownrelationship between hyperphosphataemia, secondaryhyperparathyroidism, bone turnover and extra osseouscalcifications has recently been followed by therecognition of a major role played by elevated serumphosphate levels in the induction of vascular calcifi-cation [3–5], cardiac interstitial fibrosis and arterialthickening [6] which highly increase the risk of cardiacdeath [1,2]. In response to these findings, the NationalKidney Foundation Kidney Disease Outcome QualityInitiative (K/DOQI) Clinical Practice Guidelines forbone metabolism and disease in chronic kidney diseasehas recently recommended that more stringent levelsfor controlling serum phosphorus (serum phosphoruslevels be maintained between 3.5 and 5.5mg/dl) andCa/P product in order to improve patients’ qualityof life and longevity [7].The involvement of the so-called ‘bone–coronaryaxis’ is the basis for the high clinical interest for serumconcentration of calcium and phosphate. In particular,the control or reduction of the phosphate levelin dialysis patients has become one of the maintherapeutic targets in the management of ESRD.This review focuses on the treatment of hyper-phosphataemia in patients with ESRD and in thoseunder renal replacement treatment with dialysis, anddiscusses in particular conventional phosphate bindersand emerging therapies aimed at reducing the incidenceof hyperparathyroidism, bone disease and calcificationin these patients.
Synthesis and Biological Evaluation of Novel Pyrimido[4,5-b]quinoline-2,4- dione Derivatives as MDM2 Ubiquitin Ligase Inhibitors (2013)

A series of pyrimido[4,5-b]quinoline-2,4-dione derivatives was synthesized and evaluated for their cytotoxic activities in vitro against five human cancer cell lines. Selected compounds were tested for their MDM2 E3 ligase inhibitory activities and p53-MDM2 binding inhibitory activities. Among tested compounds, four sulfur-containing compounds (4-7) displayed enhanced cytotoxic activities and better MDM2 E3 ligase inhibitoty activities in comparison with that of HLI98c. Three compounds (4-6) showed better p53-MDM2 binding inhibitory potency with IC50 values ranging from 1.3 μM to 9.0 μM.
Nucleotide sequence of the sucA gene encoding the 2‐oxoglutarate dehydrogenase of Escherichia coli K12 (1984)

The nucleotide sequence of a 3180-base-pair segment of DNA, containing the sucA gene encoding the 2-oxoglutarate dehydrogenase component (E1o) of the 2-oxoglutarate dehydrogenase complex of Escherichia coli, has been determined by the dideoxy chain-termination method. The sucA structural gene contains 2796 base pairs (932 codons, excluding the initiation codon AUG) and encodes a polypeptide having a glutamine residue at the amino terminus, a glutamate residue at the carboxy-terminus and a calculated Mr = 104905. The predicted amino acid composition is in good agreement with published information obtained by hydrolysis of the purified enzyme. There is a striking lack of sequence homology between the 2-oxoglutarate dehydrogenase (E1o) and the corresponding pyruvate dehydrogenase (E1p), which suggests that the two components are not closely related in evolutionary terms. The location and polarity of the sucA gene, relative to the restriction map of the corresponding segment of DNA, are consistent with it being the proximal gene of the suc operon, as defined in previous genetic and post-infection labelling studies, but it could also form part of a more complex regulatory unit. The sucA gene is preceded by a segment of DNA that contains many substantial regions of hyphenated dyad symmetry including an IS-like sequence of the type that is thought to function as an intercistronic regulatory element. This segment also contains three putative RNA polymerase binding sites and a good ribosome binding site.
Non‐invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice (2018)

tVNS prevents intestinal and systemic inflammation. Activation of the DMV indicates an afferent to efferent central circuitry of the tVNS stimulation and the beneficial effects of tVNS depend on an intact vagus nerve. tVNS may become a non-invasive approach for treatment of POI.
Performance Evaluation of Ethernets and ATM Networks Carrying Video Traffic (1996)

In this report the performance of Ethernets (10Base-T and 100Base-T) and ATM networks carrying multimedia traffic is presented. End-to-end delay requirements suitable for a wide range of multimedia applications are considered (ranging from 20 ms to 500 ms). Given the specific nature of the network considered and the maximum latency requirement, some data is lost. Data loss at the receiver causes quality degradations in the displayed video in the form of discontinuities, referred to as glitches. We define various quantities characterizing the glitches, namely, the total amount of information lost in glitches, their duration, and the rate at which glitches occur. We study these quantities for various network and traffic scenarios, using a computer simulation model driven by real video traffic generated by encoding video sequences. We also determine the maximum number of video streams that can be supported for given maximum delay requirement and glitch rate. We consider and compare the re...
Self-potential monitoring for hydrologic investigations in urban covered-karst terrain (2014)

ABSTRACT In the covered karst of west-central Florida, USA, sinkholes (sandy collapse conduits) provide locally concentrated recharge to underlying aquifers. For water management, it would be beneficial to understand the rates at which collapse conduits recharge an underlying aquifer. Self-potential (SP) monitoring has promise as a noninvasive, relatively low-cost method for assessing temporal variability in flow. Previous studies suggested that negative SP anomalies over collapse conduits correspond to downward-flowing groundwater; however, before SP surveys can be reliable indicators of conduit flow, SP from ET, soil conductivity changes, redox, electrode effects, and cultural noise must be better understood. A year of continuous SP monitoring with two grids of approximately 15 Pb/PbCl/KCl nonpolarizing electrodes each was combined with high-resolution ground-penetrating radar surveys and intermittent water table monitoring over two small covered-karst conduits in Tampa, Florida, USA. Although variations in SP resulting from changes in cultural noise, soil conductivity, ET, redox, and rainfall were evident, separate and unrelated positive and negative SP anomalies episodically manifested over conduits, which suggested that conduit flow could be dynamic, not static. Three flow regimes in conduits were postulated: conduit permeability higher than in surrounding surficial sediments, conduit permeability lower than in surrounding surface sediments, conduit permeability matched surrounding surface sediments. Numerical steady-state 2D simulations in Comsol created the three postulated flow regimes and revealed that a different SP polarity could result from different rates of flow: positive SP corresponded to higher permeability conduits, negative SP corresponded to lower permeability conduits, no or minimal SP appeared when conduits and surrounding sediments had equal permeability. In these models, downward flow was not responsible for generating negative SP. To assess the hydrology of a conduit, it appears that SP should be monitored continuously. Further monitoring of field sites with hydrologic sensors is needed.
A Protein Sensor for siRNA Asymmetry (2004)

To act as guides in the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) must be unwound into their component strands, then assembled with proteins to form the RNA-induced silencing complex (RISC), which catalyzes target messenger RNA cleavage. Thermodynamic differences in the base-pairing stabilities of the 5' ends of the two approximately 21-nucleotide siRNA strands determine which siRNA strand is assembled into the RISC. We show that in Drosophila, the orientation of the Dicer-2/R2D2 protein heterodimer on the siRNA duplex determines which siRNA strand associates with the core RISC protein Argonaute 2. R2D2 binds the siRNA end with the greatest double-stranded character, thereby orienting the heterodimer on the siRNA duplex. Strong R2D2 binding requires a 5'-phosphate on the siRNA strand that is excluded from the RISC. Thus, R2D2 is both a protein sensor for siRNA thermodynamic asymmetry and a licensing factor for entry of authentic siRNAs into the RNAi pathway.
X-ray powder diffraction analysis of NiZnCuSn ferrite containing antimony (1995)

Crystallographic data for Ni 0.41 Zn 0.60 Cu 0.01 Fe 2.04− x Sb x O 4+δ (0.01≤ x ≤0.12) ferrites are significantly influenced by small additions of antimony. XRD analysis reveals that changes in crystal data for small Sb substitutions differ markedly from those for greater Sb substitutions. The differences are due to the contribution of the Sb ion. Complete crystal data for six solid solution compositions are reported. An X-ray powder diffraction pattern for Ni 0.41 Zn 0.60 Cu 0.02 Sn 0.01 Fe 2.02 Sb 0.02 O 4+δ is given.
Frontal Oscillatory Dynamics Predict Feedback Learning and Action Adjustment (2011)

Frontal oscillatory dynamics in the theta (4-8 Hz) and beta (20-30 Hz) frequency bands have been implicated in cognitive control processes. Here we investigated the changes in coordinated activity within and between frontal brain areas during feedback-based response learning. In a time estimation task, participants learned to press a button after specific, randomly selected time intervals (300-2000 msec) using the feedback after each button press (correct, too fast, too slow). Consistent with previous findings, theta-band activity over medial frontal scalp sites (presumably reflecting medial frontal cortex activity) was stronger after negative feedback, whereas beta-band activity was stronger after positive feedback. Theta-band power predicted learning only after negative feedback, and beta-band power predicted learning after positive and negative feedback. Furthermore, negative feedback increased theta-band intersite phase synchrony (a millisecond resolution measure of functional connectivity) among right lateral prefrontal, medial frontal, and sensorimotor sites. These results demonstrate the importance of frontal theta- and beta-band oscillations and intersite communication in the realization of reinforcement learning.
A simple transmit diversity technique for wireless communications (1998)

This paper presents a simple two-branch transmit diversity scheme. Using two transmit antennas and one receive antenna the scheme provides the same diversity order as maximal-ratio receiver combining (MRRC) with one transmit antenna, and two receive antennas. It is also shown that the scheme may easily be generalized to two transmit antennas and M receive antennas to provide a diversity order of 2M. The new scheme does not require any bandwidth expansion or any feedback from the receiver to the transmitter and its computation complexity is similar to MRRC.
The New Leviathan. (1993)

Book Notes The New Leviathan. By R. G. Colungwood. Revised And With Additional Material Edited By David Boucher. (Oxford UP, 1993. Pp. lxi + 525. Price £50.00.) C.J. B C.J. B Search for other works by this author on: Oxford Academic Google Scholar The Philosophical Quarterly, Volume 43, Issue 173, October 1993, Pages 583–584, https://doi.org/10.2307/2220025 Published: 01 October 1993