gebhart/patrepeval huggingface dataset:
Zoned Analog Personal Teleconferencing (ZAPT) (1993)

Abstract : ZAPT is a desktop multiparty audio/video teleconferencing system at ARPA, based on Bellcore's Touring Machine ZAPT supports one multiparty call (up to 4 parties), and any number of point-to-point calls, with analog multimedia. ZAPT supports automated remote operation and conference 'joint' requests. ZAPT provides interoffice conferencing at ARPA, and manual cross-connect to Internet- style conferencing tools. Desktop, Teleconferencing, Analog, Teleconferencing, Multiparty, Multimedia.
Comparison of innervation and agrin-induced tyrosine phosphorylation of the nicotinic acetylcholine receptor (1994)

Studies of the regulation of tyrosine phosphorylation at the neuromuscular junction during development and following denervation suggest that tyrosine phosphorylation of the nicotinic acetylcholine receptor is regulated by neuronal innervation of muscle. The finding that agrin, a neuronally derived extracellular matrix protein also induces tyrosine phosphorylation of the nicotinic receptor, suggests that nerve-induced tyrosine phosphorylation may be mediated by agrin. To study this further, we have examined the regulation of tyrosine phosphorylation of the nicotinic receptor by innervation in vitro using muscle-neuron cocultures. Innervation of chick myotubes by chick ciliary ganglia neurons induced tyrosine phosphorylation of the nicotinic receptor with the same subunit specificity seen with bath applied purified agrin. Both innervation and agrin-induced phosphorylation of the nicotinic receptor resulted in an increase in tyrosine and serine phosphorylation. In addition, thermolysin phosphopeptide maps of the subunits after innervation or agrin-treatment were identical. The similarity in the agrin- and nerve-induced phosphorylation of the acetylcholine receptor suggests that agrin mediates the nerve-induced phosphorylation during development in vivo and that phosphorylation of the acetylcholine receptor may play an important role in the development of the neuromuscular junction.
A synthetic peptide to the E glycoprotein of Murray Valley encephalitis virus defines multiple virus-reactive T- and B-cell epitopes (1992)

Synthetic peptides from the envelope glycoprotein sequence of Murray Valley encephalitis (MVE) virus were previously evaluated in various strains of mice for both the induction of antibody and the in vitro proliferation of peptide-primed T-helper (Th) cells. MVE peptide 6 (amino acids 230 to 251) elicited reciprocal Th- and B-cell reactivity with native MVE virus after primary inoculation of C57BL/6 mice. In this study, we prepared overlapping subunit peptides of MVE peptide 6 and evaluated their immunogenicity. Analysis of these peptides delineated at least two B-cell epitopes that induced antibody reactive with MVE and other Japanese encephalitis serocomplex viruses. This antibody at low titer neutralized MVE virus. Genetic restriction of the antibody response to various T-cell elements within peptide 6 was observed in C3H, BALB/c, C57BL/6, and B10 congenic mice. One element demonstrable after primary immunization, located in the carboxy terminus, associated only with major histocompatibility complex class II IAb and IAbiEk glycoproteins. Functional stimulation with the peptides in association with IAkIEk and IAdIEd molecules was observed only after in vivo secondary stimulation. Peptide 6-1 (amino acids 230 to 241) was nonimmunogenic but could be recognized by Th cells from peptide 6-immunized mice. Further association of peptide 6 with the IAkIEk and IAdIEd subregions was demonstrated by the finding that T cells from MVE peptide 6-inoculated C3H and BALB/c mice primed for an antibody response to MVE virus. These results suggest that the peptide 6 sequence, which is relatively conserved among a number of flaviviruses, should be given consideration when synthetic immunogens for vaccine purposes are designed.
Hyaluronate and type III procollagen peptide concentrations in bronchoalveolar lavage fluid as markers of disease activity in farmer's lung. (1987)

Ten patients were studied during an acute episode of farmer's lung. Prominent findings were an impaired diffusion capacity (on average only 51% of predicted) and substantially increased amounts of hyaluronate and type III procollagen peptide recovered during bronchoalveolar lavage; mean concentrations of these constituents in lavage fluid were 547 (range 137-1125) and 9.7 (2.8-19.4) micrograms/l, respectively. In bronchoalveolar lavage fluid from healthy controls (n = 21) hyaluronate concentrations were less than 15 micrograms/l and procollagen peptide concentrations less than 0.2 micrograms/l. Lavage fluid concentrations of these potential markers of fibroblast activation declined during the recovery phase of farmer's lung; four to 10 weeks after admission (n = 7) mean concentrations of hyaluronate and procollagen peptide were 154 (range 38-650) and 4.4 (0.6-15.8) micrograms/l, respectively. At clinical remission six to 14 months after admission concentrations of these markers had returned almost to normal, though slightly increased concentrations were still evident in about half the patients (n = 7). At that time lung volumes were normal but diffusion capacity remained slightly subnormal. It was concluded that in farmer's lung release of hyaluronate and type III procollagen peptide reflects activity of the disease. Increased synthesis of these connective tissue components continuing in a patient avoiding mouldy plant material may signal an increased risk of developing fibrotic lung disease. The abnormal accumulation of hyaluronate in the smaller airways in acute farmer's lung may be expected to immobilize water and thereby provide a possible mechanism of the interstitial inflammatory lung oedema with associated impaired gas diffusion. This hypothesis is supported by the relation found between hyaluronate in lavage fluid and reduced diffusion capacity.
Indocyanine-green-embedded PEBBLEs as a contrast agent for photoacoustic imaging (2007)

Nanoparticles 100 nm in diameter containing indocyanine green (ICG) have been developed as a contrast agent for photoacoustic (PA) imaging based on (photonic explorers for biomedical use by biologically localized embedding PEBBLE) technology using organically modified silicate (ormosil) as a matrix. ICG is an FDA-approved dye with strong optical absorption in the near-infrared (NIR) region, where light can penetrate deepest into biological tissue. A photoacoustic imaging system was used to study image contrast as a function of PEBBLE concentration in phantom objects. ICG-embedded ormosil PEBBLEs showed improved stability in aqueous solution compared with free ICG dye. The particles were conjugated with HER-2 antibody for breast cancer and prostate cancer cell targeting. Initial in vitro characterization shows high contrast and high efficiency for binding to prostate cancer cells. ICG can also be used as a photosensitizer (generating toxic oxygen by illumination) for photodynamic therapy. We have measured the photosensitization capability of ICG-embedded ormosil nanoparticles. This feature can be utilized to combine detection and therapeutic functions in a single agent.
Novel Diarylheptanoids of Alpinia blepharocalyx (2003)

The seeds of Alpinia blepharocalyx K. Schum. (Zingiberaceae) is used in Chinese traditional medicine for the treatment of stomach disorders. From the ether fraction of a 95% ethanolic extract, which showed hepatoprotective and antiproliferative activities, we isolated 16 novel diarylheptanoids bearing a chalcone or a flavanone moiety [calyxins A-H; epicalyxins B-D, G, and H; 6-hydroxycalyxin F; and blepharocalyxins A and B] together with seven known compounds, while the residual fraction of the ethanolic extract gave 32 novel diarylheptanoids namely, calyxins A, E-G, and I-M; epicalyxins B, F, I-K, and M; deoxycalyxin A; blepharocalyxins C-E; neocalyxins A and B; (3S,5S)- and (3S,5R)-3-hydroxy-1-(4-hydroxyphenyl)-5-methoxy-7-phenyl-6E-heptene, (3S,5S)- and (3S,5R)-3-hydroxy-1-(4-hydroxyphenyl)-5-ethoxy-7-phenyl-6E-heptene, (3S)-3-methoxy-1,7-bis(4-hydroxyphenyl)-6E-hepten-5-one, 1,7-bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one, (3S,7R)-5,6-dehydro-1,7-bis(4-hydroxy-phenyl)-4"-de-O-methyl-centrolobine, (3S,5S,6S,7R)-5,6-dihydroxy-1,7-bis(4-hydroxyphenyl)-4"-de-O-me-thylcentrolobine, (3S,5R,6S,7R)- and (3S,5S,6R,7R)-5,6-dihydroxy-1,7-bis(4-hydroxyphenyl)-4"-de-O-methyl-centrolobine, 1,2- dihydro-bis(de-O-methyl)curcumin, and (3S,7S)-5,6-dehydro-4"-de-O-methylcentrolobine, and one known diarylheptanoid [(3S,5S)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane] together with 12 other known phenolic compounds. Moreover, in vitro NO inhibitory and antiproliferative activities of the isolated compounds were also tested and the active constituents identified.
Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. (1993)

The p53 protein is a transcription factor, the function of which is abrogated by oncogenic mutations which affect a flexible domain in the central portion of p53, altering its reactivity with conformation-specific antibodies. Here we show that both conformation and sequence-specific DNA binding of p53 translated in vitro can be modulated by metal chelators and oxidizing agents. Oxidation disrupted wild-type p53 conformation and inhibited DNA binding. Conversely, reduction favored folding of p53 into the wild-type form and restored DNA binding. Redox regulation of p53 protein conformation could represent an important mechanism for the control of p53 function.
Practical Synthesis of 13-bit 40-MSample/s Pipelined ADC (2005)

A 13-bit pipelined ADC achieving 67 dB SNDR without digital calibration while consuming 313mW @ 3.3V 40 MSPS is designed using analog synthesis tools. The MDACs in the pipeline have identical topology and can be synthesized to optimize pipeline performance in less than I day. Figure of merit of the three test keys comparing a manually designed, partially synthesized, and fully synthesized ADC is reported showing the efficacy and efficiency of the proposed approach
Atom-Efficient, Solvent-Free, Green Synthesis of Chalcones by Grinding (2009)

Abstract An improved Claisen–Schmidt condensation reaction of methyl ketones and aromatic aldehydes can be achieved by grinding at room temperature in the absence of solvents. This process is simple, efficient, economical, and environmentally benign compared to classical reactions.
Toward a multicore architecture for real-time ray-tracing (2008)

Significant improvement to visual quality for real-time 3D graphics requires modeling of complex illumination effects like soft-shadows, reflections, and diffuse lighting interactions. The conventional Z-buffer algorithm driven GPU model does not provide sufficient support for this improvement. This paper targets the entire graphics system stack and demonstrates algorithms, a software architecture, and a hardware architecture for real-time rendering with a paradigm shift to ray-tracing. The three unique features of our system called Copernicus are support for dynamic scenes, high image quality, and execution on programmable multicore architectures. The focus of this paper is the synergy and interaction between applications, architecture, and evaluation. First, we describe the ray-tracing algorithms which are designed to use redundancy and partitioning to achieve locality. Second, we describe the architecture which uses ISA specialization, multi-threading to hide memory delays and supports only local coherence. Finally, we develop an analytical performance model for our 128-core system, using measurements from simulation and a scaled-down prototype system. More generally, this paper addresses an important issue of mechanisms and evaluation for challenging workloads for future processors. Our results show that a single 8-core tile (each core 4-way multithreaded) can be almost 100% utilized and sustain 10 million rays/second. Sixteen such tiles, which can fit on a 240 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> chip in 22 nm technology, make up the system and with our anticipated improvements in algorithms, can sustain real-time rendering. The mechanisms and the architecture can potentially support other domains like irregular scientific computations and physics computations.
Haemopoiesis in Long-Term Bone Marrow Cultures (1979)

Bone marrow-derived adherent cell layers, containing endothelial cells, fat cells and macrophages will support prolonged haemopoiesis in vitro. Evidence suggests that the adherent layer is acting as an in vitro haemopoietic inductive environment for stem cell proliferation and differentiation into the variety of committed progenitor cells of the granulocytic, erythroid, megakaryocytic and lymphoid lineages. Using this system we have analysed the factors controlling proliferation of stem cells (CFU-S), differentiation and maturation of granulocyte/macrophage precursor cells (CFU-C), leukaemic transformation by chemicals and viruses, the role of environment versus stem cells in the aetiology of haemopoietic aplasias and the possible usefulness of long-term cultures for bone marrow transplantation.
Human regulatory T cells and their role in autoimmune disease (2006)

Summary: As self‐recognition is fundamental to the efficient operation of the immune system, a number of mechanisms have evolved to keep this potential pathologic self‐reactivity in check. Thus, even though the majority of strongly self‐reactive T cells are deleted in the thymus during T‐cell maturation, a number of mature T cells that recognize self‐antigens can be found in the peripheral circulation in healthy individuals as well as in patients with autoimmune disease. These self‐reactive cells are kept in a non‐responsive state in healthy individuals while they appear to be involved in the etiology of a number of autoimmune diseases in patients. The primary role of a relatively recently identified T‐cell population, referred to as natural CD4 + CD25 + regulatory T cells, is to modulate the activity of these self‐reactive cells. Although it is still unclear how these regulatory cells function, they can inhibit the activation of other potentially pathologic T cells in in vitro assays. Using such assays, regulatory T cells isolated from patients with a number of autoimmune diseases have been shown to exhibit reduced inhibitory function as compared with those isolated from healthy individuals. In this review, we discuss human natural regulatory T cells, what is known about their function, and their associations with specific autoimmune diseases.
T-bet-Deficient NOD Mice Are Protected from Diabetes Due to Defects in Both T Cell and Innate Immune System Function (2009)

The transcription factor T-bet (Tbx21) is critical for Th1 polarization of CD4(+) T cells. Genetic deletion of Tbx21 can cause either exacerbation or attenuation of different autoimmune diseases in animal models. In the nonobese diabetic (NOD) mouse, genetic deletion of the Ifng or the Il12b (IL-12p40) genes, which are both critical Th1 cytokines, does not reduce the incidence of autoimmune diabetes. These results suggest that autoimmune diabetes in the NOD may not be a Th1-driven disease. However, we report that Tbx21 deficiency in the NOD mouse completely blocks insulitis and diabetes due to defects both in the initiation of the anti-islet immune response and in the function of CD4(+) effector T cells. We find defective priming of naive islet-reactive T cells by the innate immune system in Tbx21(-/-) animals. By contrast to naive cells, activated islet-reactive BDC2.5 TCR-transgenic T cells do not require Tbx21 in recipient animals for efficient adoptive transfer of diabetes. However, when these BDC2.5 TCR-transgenic effector cells lack Tbx21, they are less effective at entering the pancreas and promoting diabetes than Tbx21(+/+) cells. Tbx21(-/-) regulatory T cells function normally in vitro and diabetes can be restored in Tbx21(-/-) mice by reducing regulatory T cell numbers. Thus, the absence of diabetes in the NOD.Tbx21(-/-) is due to intrinsic defects in both T cells and cells of the innate immune system paired with the relative preservation of regulatory T cell function.
Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma (2008)

Patients treated with the combination of erlotinib and temozolomide during and following radiotherapy had better survival than historical controls. Additional studies are warranted.
Intensity-Based Image Registration by Minimizing Residual Complexity (2010)

Accurate definition of the similarity measure is a key component in image registration. Most commonly used intensity-based similarity measures rely on the assumptions of independence and stationarity of the intensities from pixel to pixel. Such measures cannot capture the complex interactions among the pixel intensities, and often result in less satisfactory registration performances, especially in the presence of spatially-varying intensity distortions. We propose a novel similarity measure that accounts for intensity nonstationarities and complex spatially-varying intensity distortions in mono-modal settings. We derive the similarity measure by analytically solving for the intensity correction field and its adaptive regularization. The final measure can be interpreted as one that favors a registration with minimum compression complexity of the residual image between the two registered images. One of the key advantages of the new similarity measure is its simplicity in terms of both computational complexity and implementation. This measure produces accurate registration results on both artificial and real-world problems that we have tested, and outperforms other state-of-the-art similarity measures in these cases.
Insulin Insensitivity in Offspring of Parents with Type 2 Diabetes Mellitus (1990)

Measurements were made of the plasma glucose and insulin responses to a 75 g oral glucose challenge in 50 Chinese born in Taiwan, divided into two groups on the basis of family history of Type 2 diabetes. Twenty-five individuals (age 29 +/- 5 (+/- SD) years) had 2 parents with normal oral glucose tolerance, whereas at least 1 parent had Type 2 diabetes in the other 25 subjects (age 30 +/- 6 years). In addition, in vivo insulin action was estimated by determining the steady-state plasma glucose concentration during a 3-h continuous infusion of glucose, insulin, and somatostatin. Steady-state plasma glucose concentration was used as a measure of insulin-induced glucose disposal. The 50 subjects were non-obese, and of comparable gender distribution and body mass index. Plasma glucose and insulin concentrations in response to oral glucose were similar in the two groups. However, the steady-state plasma glucose concentration was significantly (p less than 0.01) higher in offspring with a family history of Type 2 diabetes when compared by two-way analysis of variance (mean +/- SE was 5.87 +/- 0.27 vs 5.12 +/- 0.32 mmol l-1). This difference was found despite a significantly (p less than 0.01) higher steady-state plasma insulin concentration during the infusion studies (0.705 +/- 0.027 vs 0.643 +/- 0.025 nmol l-1) in offspring of people with diabetes. The results support the view that resistance to insulin-stimulated glucose uptake is present in offspring of diabetic parents.
Surgical Treatment of Idiopathic Adolescent Scoliosis (1999)

From the Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri. Address reprint requests to Keith H. Bridwell, MD Department of Orthopaedic Surgery Washington University School of Medicine One Barnes–Jewish Hospital Plaza Suite 11300 West Pavilion St. Louis, MO 63110 [email protected]
Analysis and Modeling of Pedestrian Crossing Behavior During the Pedestrian Flashing Green Interval (2014)

Pedestrian-vehicle conflicts are considered one of the most common safety problems at signalized intersections. In Japan, the pedestrian flashing green (PFG) is considered a safe time interval for pedestrians at crosswalks to finish crossing before conflicting vehicle streams are released. In most common phasing schemes, pedestrians have the right-of-way along with left-turning vehicles (in left-hand traffic). By law, pedestrians should not enter a crosswalk during the PFG. However, many of them rush into crosswalks without necessarily heeding approaching turning vehicles, which could increase the probability of severe conflicts. The objective of this paper is to analyze and model the probabilistic behavior of pedestrians after the onset of the PFG, which contains the pedestrians' decision of whether to give up crossing, as well as the pedestrian speed distribution. Empirical data analysis showed that longer crosswalks lead to significantly higher pedestrian stop probabilities. Furthermore, there is a significant difference between the pedestrians' speeds in the first and second halves of crosswalks. The results of a Monte Carlo simulation showed that the estimated models closely represent the overall stochastic behavior of the pedestrians from the onset of the PFG until the completion of crossing.
High-speed (104 °C/s) scanning microcalorimetry with monolayer sensitivity (J/m2) (1995)

We introduce a high sensitivity (1J/m2) scanning microcalorimeter that can be used at high heating rates (104 °C/s). The system is designed using ultrathin SiN membranes that serve as a low thermal mass mechanical support structure for the calorimeter. Calorimetry measurements of the system are accomplished via resistive heating techniques applied to a thin film Ni heating element that also serves as a thermometer. A current pulse through the Ni heater generates heat in the sample via Joule heating. The voltage and current characteristics of the heater were measured to obtain real-time values of the temperature and the heat delivered to the system. This technique shows potential for measuring irreversible heat of reactions for processes at interfaces and surfaces. The method is demonstrated by measuring the heat of fusion for various amounts of thermally evaporated Sn ranging from 50 to 1000 Å.
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo (2006)

Olig gene expression is proposed to mark the common progenitors of motoneurons and oligodendrocytes. In an attempt to further dissect the in vivo lineage relationships between motoneurons and oligodendrocytes, we used a conditional cell-ablation approach to kill Olig-expressing cells. Although differentiated motoneurons and oligodendrocytes were eliminated, our ablation study revealed a continuous generation and subsequent death of their precursors. Most remarkably, a normal number of oligodendrocyte precursors are formed at day 12 of mouse development, after all motoneuron precursors have been killed. The data presented herein supports a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in vivo from neuroepithelial stem cells, but do not share a common lineage-restricted progenitor.
Performance of an ideal wireless orbital angular momentum communication system using multiple-input multiple-output techniques (2014)

A wireless orbital angular momentum (OAM) communication system is modeled using multiple-input multiple-output (MIMO) techniques. The channel matrix is derived using the azimuthal phase profile of the OAM modes. A simulation of an ideal line of sight (LOS) infrastructure, based on the model is also presented. It consists of concentric circular array OAM generators at the transmitting side and a uniform circular array of conventional antennas at the receiving side. The results show that, the channel matrix achieves full rank and has equal eigenvalues. The transmission of OAM modes can therefore be used to maximize channel capacity in LOS MIMO communication systems.