gebhart/patrepeval huggingface dataset:
Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome. (1990)

Oxidative stress has been implicated in the adult respiratory distress syndrome (ARDS). In this study, we determined the levels of selected antioxidants in the plasma of 25 patients with ongoing ARDS and 16 healthy control subjects. We also examined these plasmas and pulmonary edema fluid of ARDS patients for lipid hydroperoxides. Both ascorbate and ubiquinol-10 concentrations in ARDS plasma were significantly lower than in normal plasma. alpha-Tocopherol concentrations, when standardized to total plasma cholesterol, were not lower in ARDS patients than in normal subjects. A pattern of antioxidant levels virtually identical to that observed in ARDS plasma was obtained after in vitro incubation of healthy plasma with stimulated polymorphonuclear leukocytes: very low ascorbate, decreased ubiquinol-10, and unchanged alpha-tocopherol concentrations. Nanomolar concentrations of lipid hydroperoxides were found in pulmonary edema fluid of ARDS patients, but not in plasma, nor in the plasma of healthy individuals, when a sensitive and selective chemiluminescence assay for hydroperoxides was used. ARDS patients also showed significant decreases in plasma levels of cholesterol esters in conjunction with discoidal high-density lipoprotein profiles, indicating a decrease in lecithin-cholesterol acyltransferase activity. We conclude that ARDS is associated with oxidative stress, possibly exerted by oxidants released from activated phagocytic leukocytes, and major changes in plasma cholesterol metabolism.
Towards a truthful world wide web from a humanitarian perspective (2015)

Economy grows as more and more people join its core echelons. People are the most important economic resources at all times. The Web, being humanity's largest source of information and interaction, probably has the most technological potential to get people into mainstream. It can serve as a conduit of humanitarian services to the underprivileged and presents a huge opportunity to meet humanitarian challenges. In this paper, we discuss the role that a truthful World Wide Web can play in achieving humanitarian goals. We survey what is currently available and discuss some of our own ideas on making the Web more robust and truthful in order to meet the humanitarian challenge.
A unified analysis of MMIC power amplifier stability (2003)

The author develops the mathematical framework and techniques for predicting possible oscillations for all n modes in order to ensure MMIC monolithic microwave integrated circuit stability. Although the analysis is applicable to any number of combined devices, only the cases for n=2 and 4 are discussed. These two cases illustrate the special considerations that apply for small numbers of combined devices (n=2) and the difficulties in analyzing larger numbers of combined devices (n=4). It was shown that the stability of the amplifier for all modes (even and odd) can be checked using small signal analysis software.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Twenty proteins containing a C-terminal SOCS box form five structural classes (1998)

The four members of the recently identified suppressor of cytokines signaling family (SOCS-1, SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) appear, by various means, to negatively regulate cytokine signal transduction. Structurally, the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. By using the SOCS box amino acid sequence consensus, we have searched DNA databases and have identified a further 16 proteins that contain this motif. These proteins fall into five classes based on the protein motifs found N-terminal of the SOCS box. In addition to four new SOCS proteins (SOCS-4 to SOCS-7) containing an SH2 domain and a SOCS box, we describe three new families of proteins that contain either WD-40 repeats (WSB-1 and -2), SPRY domains (SSB-1 to -3) or ankyrin repeats (ASB-1 to -3) N-terminal of the SOCS box. In addition, we show that a class of small GTPases also contains a SOCS box. The expression of representative members of each class of proteins differs markedly, as does the regulation of expression by cytokines. The function of the WSB, SSB, and ASB protein families remains to be determined.
Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles. (1991)

The transport of pro-alpha-factor from the ER to the Golgi apparatus in gently lysed yeast spheroplasts is mediated by diffusible vesicles. These transport vesicles contain core-glycosylated pro-alpha-factor and are physically separable from donor ER and target Golgi compartments. The formation of diffusible vesicles from the ER requires ATP, Sec12p, Sec23p, and GTP hydrolysis. The vesicles produced are functionally distinct from the ER: they transfer pro-alpha-factor to the Golgi apparatus faster and more efficiently than the ER, they do not require Sec12p or Sec23p to complete transfer, and transfer is resistant to GTP gamma S. Targeting of vesicles to the Golgi apparatus requires Ypt1p and Sec18p. Fusion of vesicles that have targeted requires calcium and ATP.
Current and potential food and non-food applications of fructans (1991)

Conference Article| August 01 1991 Current and potential food and non-food applications of fructans Adriaan Fuchs Adriaan Fuchs 1Netherlands Organization for Applied Scientific Research TNO, Department of Phytopathology, Wageningen Agricultural University, 6700 EE Wageningen, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1991) 19 (3): 555–560. https://doi.org/10.1042/bst0190555 Article history Received: April 12 1991 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Adriaan Fuchs; Current and potential food and non-food applications of fructans. Biochem Soc Trans 1 August 1991; 19 (3): 555–560. doi: https://doi.org/10.1042/bst0190555 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: DP, degree of polymerization, SST, sucrose:sucrose fructosyltransferase, FFT, fructan:fructan fructosyltransferase, HMF, 5-hydro-oxymethyl-furfural, MDH, mannitol dehydrogenase This content is only available as a PDF. © 1991 Biochemical Society1991 Article PDF first page preview Close Modal You do not currently have access to this content.
Peak to average power ratio reduction in multi-band transmitters; analysis, design and FPGA implementation (2005)

This paper addresses the problem of peak to average power ratio (PAPR) reduction in multi-band transmitters. Transmitter linearity requirements are addressed and trade-off analysis for design and optimization of the PAPR reduction algorithm within the context of the error vector magnitude (EVM) and adjacent channel leakage ratio (ACLR) quality metrics are studied. Our study also includes mapping of the signal processing algorithms onto Xilinx Virtex-4trade field programmable gate array (FPGA) technology and addresses the device resource utilization and efficient hardware implementation of the above PAPR reduction algorithms onto the above mentioned device. Statistical simulations and performance assessments of the proposed algorithms are presented
Stability of Ophthalmic Atropine Solutions for Child Myopia Control (2020)

Myopia is an ophthalmic condition affecting more than 1/5th of the world population, especially children. Low-dose atropine eyedrops have been shown to limit myopia evolution during treatment. However, there are currently no commercial industrial forms available and there is little data published concerning the stability of medications prepared by compounding pharmacies. The objective of this study was to evaluate the stability of two 0.1 mg/mL atropine formulations (with and without antimicrobiobial preservatives) for 6 months in two different low-density polyethylene (LDPE) multidose eyedroppers. Analyses used were the following: visual inspection, turbidity, chromaticity measurements, osmolality and pH measurements, atropine quantification by a stability-indicating liquid chromatography method, breakdown product research, and sterility assay. In an in-use study, atropine quantification was also performed on the drops emitted from the multidose eyedroppers. All tested parameters remained stable during the 6 months period, with atropine concentrations above 94.7% of initial concentration. A breakdown product (tropic acid) did increase slowly over time but remained well below usually admitted concentrations. Atropine concentrations remained stable during the in-use study. Both formulations of 0.1 mg/mL of atropine (with and without antimicrobial preservative) were proved to be physicochemically stable for 6 months at 25 °C when stored in LDPE bottles, with an identical microbial shelf-life.
The Ascending Auction Paradox (1999)

We examine uniform-price, multiple-unit auctions that are dynamic rather than sealedbid, auctions where the price ascends, giving bidders the chance to observe and respond to the bidding. In this dynamic setting, subgame perfection can be exploited to refine the set of equilibria. Restricting attention to ascending auctions where two bidders with complete and perfect information alternate placing bids until the market clears, we show that in the unique equilibrium each bidder reduces her quantity to the market-clearing level at her first opportunity, when the price has not yet risen. For much the same reason that Rubinstein bargainers choose to trade immediately even though they could alternate making offers indefinitely, a bidder in an ascending auction calculates where the auction would go, and then uses backward induction to find an offer that is acceptable to her rival at the start of the auction.
MECHANICAL PROPERTIES OF SOME TANTALUM ALLOYS (1967)

The mechanical properties of a series of Ta–Re alloys and some Ta–Mo and Ta–W alloys have been investigated by deforming single crystals in compression. Experimental results on slip-line observations, stress–strain curves, yield stresses and anisotropic elastic constants are presented. Slip occurs on the {110} planes; twinning is never observed and the alloys become increasingly brittle as the solute concentration is increased or the temperature is decreased. Yield stress versus composition curves show a minimum at low temperatures. It is suggested that this is due to a reduction in the intrinsic lattice friction stress of the pure metal by alloying, before alloy hardening is able to increase the yield stress again. The alloy hardening has been analyzed and the yield stress τ, the solute concentration c, and the temperature T are related by an expression [Formula: see text], where k and T 0 are constants and μ is the shear modulus. Such a relationship has been derived by Fleischer for interactions of dislocations with tetragonal distortions. It is unlikely that this implies that tetragonal defects (for example, solute pairs) are important in tantalum alloys; presumably elastic interactions with single solute atoms can also give such a temperature and concentration dependence of the yield stress. Comparisons with other b.c.c. alloys have been made and it is found that the rate of alloy hardening is directly proportional to the atomic size misfit in most of the alloys where data are available for single crystals.
3D model acquisition from uncalibrated images (1998)

In this paper we address the problem of recovering 3D models from uncalibrated images of architectural scenes. We propose a simple, geometrically intuitive method which exploits strong rigidity constraints such as parallelism and orthogonality present in indoor and outdoor architectural scenes. We show how these simple constraints can be used to calibrate the cameras and to recover the 3 \\Theta 4 projection matrices for each viewpoint. The projection matrices are used to recover partial 3D models of the scene and these can be used to visualise new viewpoints. Our approach does not need any a priori information about the cameras being used. A working system has been designed and implemented to allow the user to interactively build a 3D model from a pair of uncalibrated images from arbitrary viewpoints. 1 Introduction Considerable efforts have been made to recover photorealistic models of the real world. The most common geometric approach is to attempt to recover 3D models from calibrat...
Frictional Resistance in Fiber Suspensions : 2nd Report, Flow on a rotating Disk (1983)

The frictional moment : in fiber suspensions is measured to investigate experimentally the flow on a rotating disk. In laminar region and in case of aspect ratio beyond 200, the fiber flocculence increases the frictional resistance. In turbulent region, the drag reduction increases with the aspect ratio. Though the effect of disk diameter is little, the drag reduction increases with the diameter. These phenomena are correlated with those in pipe flow.
Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription (1992)

NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat-I to stimulate transcription of HIV in Jurkat T-leukemia cells. We have found that the p49(100) DNA binding subunit, together with p65, can act in concert with Tat-I to stimulate the expression of HIV-CAT plasmid. Little effect was observed with 50-kDa forms of p105 NF-kappa B or rel, in combination with p65 or full-length c-rel, which do not stimulate the HIV enhancer in these cells. These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA.
The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver (1998)

Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned the full-length cDNA of the sister of P-glycoprotein (spgp; Mr approximately 160,000) of rat liver and demonstrated that it functions as an ATP-dependent bile salt transporter in cRNA injected Xenopus laevis oocytes and in vesicles isolated from transfected Sf9 cells. The latter demonstrated a 5-fold stimulation of ATP-dependent taurocholate transport as compared with controls. This spgp-mediated taurocholate transport was stimulated solely by ATP, was inhibited by vanadate, and exhibited saturability with increasing concentrations of taurocholate (Km approximately 5 microM). Furthermore, spgp-mediated transport rates of various bile salts followed the same order of magnitude as ATP-dependent transport in canalicular rat liver plasma membrane vesicles, i.e. taurochenodeoxycholate > tauroursodeoxycholate = taurocholate > glycocholate = cholate. Tissue distribution assessed by Northern blotting revealed predominant, if not exclusive, expression of spgp in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ immunofluorescence and immunogold labeling studies. These results indicate that the sister of P-glycoprotein is the major canalicular bile salt export pump of mammalian liver.
Optical properties of yellow light-emitting diodes grown on semipolar (112¯2) bulk GaN substrates (2008)

We demonstrate high power yellow InGaN single-quantum-well light-emitting diodes (LEDs) with a peak emission wavelength of 562.7nm grown on low extended defect density semipolar (112¯2) bulk GaN substrates by metal organic chemical vapor deposition. The output power and external quantum efficiency at drive currents of 20 and 200mA under pulsed operation (10% duty cycle) were 5.9mW, 13.4% and 29.2mW, 6.4%, respectively. It was observed that the temperature dependence of the output power of InGaN LEDs was significantly smaller than that of AlInGaP LEDs.
Antisense Oligonucleotide Directed to Human Apolipoprotein B-100 Reduces Lipoprotein(a) Levels and Oxidized Phospholipids on Human Apolipoprotein B-100 Particles in Lipoprotein(a) Transgenic Mice (2008)

Mipomersen significantly reduced Lp(a) and OxPL/apoB levels in Lp(a) mice. The present study demonstrates that h-apoB-100 is a limiting factor in Lp(a) particle synthesis in this Lp(a) transgenic model. If applicable to humans, mipomersen may represent a novel therapeutic approach to reducing Lp(a) levels and their associated OxPL.
Triazolinone Biphenylsulfonamide Derivatives as Orally Active Angiotensin II Antagonists with Potent AT1 Receptor Affinity and Enhanced AT2 Affinity (1994)

Several series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones with acidic sulfonamide replacements of tetrazole at the 2'-position of the biphenyl-4-ylmethyl side chain at N4 were prepared and tested as angiotensin II (AII) antagonists. Preferred substituents on the triazolinone ring were n-butyl at C5 and 2-(trifluoromethyl)phenyl at N2. Subnanomolar IC50 values at the AT1 receptor subtype were observed for a variety of acylsulfonamides, including aroyl, heteroaroyl, and cycloalkylcarbonyl derivatives. Certain other acidic sulfonamides, such as sulfonylcarbamates and disulfimides also displayed high affinity for the AT1 receptor. In addition, AT2 binding for some of these compounds was increased by as much as 1000-fold over the corresponding tetrazole (e.g., AT2 IC50 17 nM for the tert-butyl sulfonylcarbamate 92). When evaluated for inhibition of the AII pressor response, the benchmark benzoylsulfonamide 9 (L-159,913) was efficacious in several species and was superior to losartan (1a) in conscious rhesus monkeys. Several subsequent analogues, including the 2-chlorobenzoyl (18), (3-chlorothiophene-2-yl)carbonyl (51), ((S)-2,2-dimethylcyclopropyl)carbonyl (80), and tert-butoxycarbonyl (92) derivatives, were highly effective in rats, surpassing 9 and losartan in duration of action and/or potency. Compound 18 (L-162,223) displayed very prolonged AII antagonism in the rat model (> 24 h at 1 mg/kg iv). At 1 mg/kg po in rats, 18 and 92 (L-162,234) produced 85-87% peak inhibition of the AII pressor response with duration exceeding 6 h. The identification of triazolinone-based sulfonamide derivatives combining high AT1 affinity, considerably enhanced AT2 potency, and favorable in vivo properties provides insights relevant to the design of dual AT1/AT2 receptor antagonists.
Venous thromboembolism (VTE) in Europe (2007)

Venous thromboembolism (VTE) is often asymptomatic, mis-diagnosed, and unrecognized at death, and there is a lack of routine postmortem examinations. These factors are thought to result in marked underestimates ofVTE incidence. The objective of our study was to estimate the total burden of VTE within the European Union (EU) per annum. An epidemiological model was constructed to estimate the number of community- and hospital-acquired incidents and recurrent cases (attack rate) of nonfatal VTE and VTE-related deaths, as well as incident and prevalent cases of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (PH) occurring in the EU per annum. Individual models were developed for six EU countries. The models were populated with data from published literature and, where necessary, expert opinions. The findings were tested using probabilistic sensitivity analyses. The estimated total number of symptomaticVTE events (range based on probabilistic sensitivity analysis) per annum within the six EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths. Of these deaths, an estimated 27,473 (7%) were diagnosed as being antemortem; 126,145 (34%) were sudden fatal PE, and 217,394 (59%) followed undiagnosed PE. Almost three-quarters of all VTE-related deaths were from hospital-acquired VTE. VTE is a major health problem in the EU, with over one million VTE events or deaths per annum in the six countries examined. Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented. These results have important implications for the allocation of healthcare resources.
Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4 (2011)

Adoptive transfer of MAGE-A4-specific T cells, combined with epigenetic modifying drugs to increase expression of the protein, may improve treatment of relapsed HL.
Asymmetric Lithium(I) and Copper(II) Alkoxy‐N‐heterocyclic Carbene Complexes; Crystallographic Characterization and Lewis Acid Catalysis. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Pocket‐Sized Convective PCR Thermocycler (2007)

Is that a PCR in your pocket? An innovative thermocycling system is presented that harnesses natural convection to perform rapid multiplex and long-target DNA amplification by the polymerase chain reaction (PCR). The design is inherently simple and consumes minimal electrical power, enabling a pocket-sized battery-powered device to be constructed at a cost of approximately US$10. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700306_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Arabidopsis thaliana CBF1 encodes an AP2 domain-containing transcriptional activator that binds to the C-repeat/DRE, a cis-acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit (1997)

Recent efforts have defined a cis-acting DNA regulatory element in plants, the C-repeat/dehydration responsive element (DRE), that stimulates transcription in response to low temperature and water deficit. Here we report the isolation of an Arabidopsis thaliana cDNA that encodes a C-repeat/DRE binding factor, CBF1 (C-repeat/DRE Binding Factor 1). Analysis of the deduced CBF1 amino acid sequence indicates that the protein has a molecular mass of 24 kDa, a potential nuclear localization sequence, and a possible acidic activation domain. CBF1 also has an AP2 domain, which is a DNA-binding motif of about 60 aa present in the Arabidopsis proteins APETALA2, AINTEGUMENTA, and TINY; the tobacco ethylene response element binding proteins; and numerous other plant proteins of unknown function. The transcript levels for CBF1, which appears to be a single or low copy number gene, did not change appreciably in plants exposed to low temperature or in detached leaves subjected to water deficit. Binding of CBF1 to the C-repeat/DRE was demonstrated in gel shift assays using recombinant CBF1 protein expressed in Escherichia coli. Moreover, expression of CBF1 in yeast was found to activate transcription of reporter genes containing the C-repeat/DRE as an upstream activator sequence but not mutant versions of the DNA element. We conclude that CBF1 can function as a transcriptional activator that binds to the C-repeat/DRE DNA regulatory element and, thus, is likely to have a role in cold- and dehydration-regulated gene expression in Arabidopsis.