gebhart/patrepeval huggingface dataset:
Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice (1998)

The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant immunization is an important factor hampering the use of certain vaccines, such as measles or respiratory syncytial virus vaccine, in early infancy. The resulting delay in protection by conventional or novel vaccines may have significant public health consequences. To define immunization approaches which may circumvent this phenomenon, experiments were set up to further elucidate its immunological bases. The influence of maternal antibodies on antibody and T cell responses to measles hemagglutinin (MV-HA) were analyzed following MV-HA immunization of pups born to immune or control BALB/c mothers using four different antigen delivery systems: live or inactivated conventional measles vaccine, a live recombinant canarypox vector and a DNA vaccine. High levels (> 5 log10) of maternal anti-HA antibodies totally inhibited antibody responses to each of the vaccine constructs, whereas normal antibody responses were elicited in presence of lower titers of maternal antibodies. However, even high titers of maternal antibodies affected neither the induction of vaccine-specific Th1/Th2 responses, as assessed by proliferation and levels of IFN-gamma and IL-5 production, nor CTL responses in infant mice. On the basis of these unaltered T cell responses, very early priming and boosting (at 1 and 3 weeks of age, respectively) with live measles vaccine allowed to circumvent maternal antibody inhibition of antibody responses in pups of immune mothers. This was confirmed in another immunization model (tetanus toxoid). It suggests that effective vaccine responses may be obtained earlier in presence of maternal antibodies through the use of appropriate immunization strategies using conventional or novel vaccines for early priming.
THE PREPARATION OF 2,4-DIHYDROXYDIPHENYLMETHANE AND OF 2,4-DIHYDROXYDIPHENYLETHANE (1926)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE PREPARATION OF 2,4-DIHYDROXYDIPHENYLMETHANE AND OF 2,4-DIHYDROXYDIPHENYLETHANEEmil KlarmannCite this: J. Am. Chem. Soc. 1926, 48, 3, 791–794Publication Date (Print):March 1, 1926Publication History Published online1 May 2002Published inissue 1 March 1926https://pubs.acs.org/doi/10.1021/ja01414a042https://doi.org/10.1021/ja01414a042research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats (2015)

The results showed that WSAq exhibited antioxidant and anti-arthritic activity and reduced inflammation in CIA rats and suggests the potential use of this plant in the treatment of arthritis.
Enzymatic completion of mammalian lagging-strand DNA replication. (1994)

Using purified proteins from calf and a synthetic substrate, we have reconstituted the enzymatic reactions required for mammalian Okazaki fragment processing in vitro. The required reactions are removal of initiator RNA, synthesis from an upstream fragment to generate a nick, and then ligation. With our substrate, RNase H type I (RNase HI) makes a single cut in the initiator RNA, one nucleotide 5' of the RNA-DNA junction. The double strand specific 5' to 3' exonuclease removes the remaining monoribonucleotide. After dissociation of cleaved RNA, synthesis by DNA polymerase generates a nick, which is then sealed by DNA ligase I. The unique specificities of the two nucleases for primers with initiator RNA strongly suggest that they perform the same reactions in vivo.
[A case of lung cancer with hereditary angioedema treated effectively by chemo-radiotherapy with C1 esterase inhibitor concentrate and danazol]. (2004)

Lung cancer with hereditary angioedema was diagnosed in a 69-year-old man. Laboratory examinations revealed depletion of the fourth component of complement and C1 inhibitor activity. A bone metastasis was present. After the first chemotherapy, acute attacks of edema in the upper chest and the laryngeal mucosa occurred and dyspnea progressed, but these symptoms were immediately improved by administration of C1 inhibitor concentrate. Because of the danger of angioedema that might be expected following chemo-radiotherapy, he was treated with danazol. The patient then showed no sign of an edema attack during therapy for lung cancer.
Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture (1993)

Multisite extracellular electrical activity and intracellular calcium were recorded simultaneously. Electrical signals were measured using microelectrode array substrates. A novel cell positioning technique was combined with a method for controlling neurite outgrowth, which allowed cell-electrode contacts to be established easily, thus facilitating the electrical recording. Intracellular calcium was measured optically using the indicator fluo 3. Under low-magnesium conditions, cultured rat cortical neurons showed periodic transients of fluo-3 fluorescence, which were synchronized with the periodic bursting observed electrically. The intervals between bursts could be determined by electrical stimulation through the substrate electrodes. The results suggest that functional synaptic connections are formed in the culture system.
A novel time of arrival estimation algorithm using an energy detector receiver in MMW systems (2017)

This paper presents a new time of arrival (TOA) estimation technique using an improved energy detection (ED) receiver based on the empirical mode decomposition (EMD) in an impulse radio (IR) 60 GHz millimeter wave (MMW) system. A threshold is employed via analyzing the characteristics of the received energy values with an extreme learning machine (ELM). The effect of the channel and integration period on the TOA estimation is evaluated. Several well-known ED-based TOA algorithms are used to compare with the proposed technique. It is shown that this ELM-based technique has lower TOA estimation error compared to other approaches and provides robust performance with the IEEE 802.15.3c channel models.
NAS-Bench-101: Towards Reproducible Neural Architecture Search (2019)

Recent advances in neural architecture search (NAS) demand tremendous computational resources, which makes it difficult to reproduce experiments and imposes a barrier-to-entry to researchers without access to large-scale computation. We aim to ameliorate these problems by introducing NAS-Bench-101, the first public architecture dataset for NAS research. To build NAS-Bench-101, we carefully constructed a compact, yet expressive, search space, exploiting graph isomorphisms to identify 423k unique convolutional architectures. We trained and evaluated all of these architectures multiple times on CIFAR-10 and compiled the results into a large dataset of over 5 million trained models. This allows researchers to evaluate the quality of a diverse range of models in milliseconds by querying the pre-computed dataset. We demonstrate its utility by analyzing the dataset as a whole and by benchmarking a range of architecture optimization algorithms.
TERRAMYCIN. VIII. STRUCTURE OF AUREOMYCIN AND TERRAMYCIN (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTERRAMYCIN. VIII. STRUCTURE OF AUREOMYCIN AND TERRAMYCINC. R. Stephens, L. H. Conover, F. A. Hochstein, P. P. Regna, F. J. Pilgrim, K. J. Brunings, and R. B. WoodwardCite this: J. Am. Chem. Soc. 1952, 74, 19, 4976–4977Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://doi.org/10.1021/ja01139a533RIGHTS & PERMISSIONSArticle Views266Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (234 KB) Get e-Alertsclose Get e-Alerts
Articulated Object Reconstruction and Markerless Motion Capture from Depth Video (2008)

Abstract We present an algorithm for acquiring the 3D surface geometry and motion of a dynamic piecewise‐rigid object using a single depth video camera. The algorithm identifies and tracks the rigid components in each frame, while accumulating the geometric information acquired over time, possibly from different viewpoints. The algorithm also reconstructs the dynamic skeleton of the object, thus can be used for markerless motion capture. The acquired model can then be animated to novel poses. We show the results of the algorithm applied to synthetic and real depth video.
Facile functionalization of FK506 for biological studies by the thiol–ene ‘click’ reaction (2014)

An efficient one-step functionalization of FK506 by the thiol–ene click (TEC) reaction is reported. This approach, which enables rapid and quantitative generation of bioactive FK1012 and FK506 derivatives, should facilitate biomedical applications of FK506-coupled molecules and expand the scope of the TEC reaction in natural product semi-synthesis.
Immunity by design: an artificial immune system (1999)

We describe an artificial immune system (AIS) that is distributed, robust, dynamic, diverse and adaptive. It captures many features of the vertebrate immune system and places them in the context of the problem of protecting a network of computers from illegal intrusions.
A genetic algorithm for designing gene family-specific oligonucleotide sets used for hybridization: the G protein-coupled receptor protein superfamily. (1998)

kel@.bionet.nsc.ru; sebastian. meier-ewert@gpc-ag.com
<title>Invariant pattern recognition using higher-order neural networks</title> (1992)

The paper provides a discussion of the results derived from the theory of invariant higher- order neural networks to design a system which will produce an invariant classification solution for a particular pattern recognition problem. This is done by employing a generalized to higher-orders back-propagation algorithm with reduced network connectivity. In special case optimal solution is obtained using linear equation technique. In both cases the volume of computations in the algorithm is much less, than that of the other methods. We demonstrate that the system can correctly classify shifted, rotated, scaled and distorted patterns with a certain amount of noise.
Acute myeloid leukemia: 2014 Update on risk‐stratification and management (2014)

Evidence suggests that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mortality and resistance to therapy, the latter the principal cause of failure even in patients aged 70 or above. We emphasize the limitations of prediction of resistance based only on pre-treatment factors and stress the need to incorporate post-treatment factors, for example indicators of minimal residual disease. We review various newer therapeutic options and considerations that underlie the decision to recommend allogeneic hematopoietic cell transplant.
Abstract 3218: Disruption of the CD39 immune checkpoint pathway increases the efficacy of various anticancer therapies in syngeneic mouse models (2016)

Abstract The CD39-CD73-adenosine pathway is an emerging regulator of the immune antitumor response. CD39 is expressed within tumors and the tumor microenvironment by several cell population including immune and cancer cells. In tumor tissues, the pathway leads to the accumulation of immunosuppressive adenosine together with decreased levels of immunoactivating peritumoral ATP. We reported previously that CD39 blockade increased T cell and NK cell-mediated cytotoxic activity in vitro and disclose, during this meeting, the development of the first human-CD39-blocking humanized antibody (S. Augier et al., Preclinical development of a humanized blocking antibody targeting the CD39 immune checkpoint for cancer immunotherapy). Here we demonstrated that this pathway is involved in tumor-induced resistance to various cancer therapies in syngeneic mouse melanoma, colon cancer and fibrosarcoma models. We used therapy-resistant mouse models or inefficacious treatment regimens in the CD39 knockout mice to assess the capacity of CD39 to affect the response to chemotherapies, tumor associated antigen (TAA)-targeting antibodies and immunomodulators such as anti-PD1 antibodies. We achieved increased response rates, increased response duration and some complete and long lasting tumor regressions in the CD39 deficient context. These preclinical proof-of-concept studies highlight the role of the CD39 immune checkpoint pathway in limiting the efficacy of various anticancer therapies in syngeneic mouse models and thereby support the potential clinical value of the humanized CD39-neutralizing antibody under development. Citation Format: Marion Lapierre, Cécile Dejou, Carine Paturel, Henri-Alexandre Michaud, Laurent Gros, Armand Bensussan, Jean-François Eliaou, Jeremy Bastid, Nathalie Bonnefoy. Disruption of the CD39 immune checkpoint pathway increases the efficacy of various anticancer therapies in syngeneic mouse models. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3218.
Failure characteristics of multiple‐component fibrin‐based adhesives (2001)

A series of analyses were performed on fibrin-based adhesives to describe their failure characteristics. Two test methods were used: uniaxial, monotonic tensile testing of the bulk material, and blister testing using fresh porcine-source skin graft as the adherend. Two fibrin concentrations, high (HFC), and low (LFC), were used to investigate the effects of the gel matrix density upon mechanical properties. In tensile tests, fibrin gels strain hardened, as functions of percent strain and of strain rate. An increase in modulus of elasticity (E) was seen with increasing strain and strain rate at both tested fibrin concentrations. Mode I failure mechanisms were predominant. Both adhesives appeared to fracture from the outer edge to the interior of the specimen at slower strain rate tests. This trend reversed as strain rate increased, becoming a classic "cup and cone" ductile fracture. Syneresis occurred at both concentrations at lower strain rates, but was more pronounced for the LFC. Ultimate tensile strength and E were greater for the HFC than for the LFC at all strain rates, decreasing with increasing strain rate. In the blister test, the failure locus changed from cohesive to adhesive as the strain rate was increased for the HFC. Failure of fibrin gels likely occurs by percolation of the pressurized saline, displacing the entrapped liquid phase of the gel in regions of relatively low moduli and strength, leading to fracture of the matrix. For LFC, the overall fracture locus remained predominantly cohesive regardless of strain rate. Burst strength and failure energy were higher for HFC than for LFC. It would appear that fibrin acts more as a viscous liquid than a rubberlike/elastic material at lower concentrations because adhesive failures had a higher burst strength and fracture energy (Gc) than did cohesive failures.
Immunoglobulin G antibody capture enzyme-linked immunosorbent assay: a versatile assay for detection of anti-human immunodeficiency virus type 1 and 2 antibodies in body fluids (1992)

In tests on specimens of dried blood, saliva, and urine from 55 human immunodeficiency virus (HIV)-seropositive and 55 HIV-seronegative patients, an immunoglobulin G capture enzyme immunoassay for the detection of antibodies to HIV types 1 and 2, GACELISA, gave 109 of 110, 109 of 109, and 109 of 110 correct results, respectively. This performance, achieved in a laboratory previously unfamiliar with the assay, suggests that GACELISA is a useful new epidemiological tool for the study of HIV infection, equally applicable to all three kinds of specimen.
Chemical Synthesis of Novel Plasmonic Nanoparticles (2008)

Under the irradiation of light, the free electrons in a plasmonic nanoparticle are driven by the alternating electric field to collectively oscillate at a resonant frequency in a phenomenon known as surface plasmon resonance. Both calculations and measurements have shown that the frequency and amplitude of the resonance are sensitive to particle shape, which determines how the free electrons are polarized and distributed on the surface. As a result, controlling the shape of a plasmonic nanoparticle represents the most powerful means of tailoring and fine-tuning its optical resonance properties. In a solution-phase synthesis, the shape displayed by a nanoparticle is determined by the crystalline structure of the initial seed produced and the interaction of different seed facets with capping agents. Using polyol synthesis as a typical example, we illustrate how oxidative etching and kinetic control can be employed to manipulate the shapes and optical responses of plasmonic nanoparticles made of either Ag or Pd. We conclude by highlighting a few fundamental studies and applications enabled by plasmonic nanoparticles having well-defined and controllable shapes.
Java JNI Bridge: A Framework for Mixed Native ISA Execution (2006)

Managed runtime environments (MRTEs) such as the Java platform promise a cross platform "write once, deploy anywhere" mechanism. However, MRTE applications that contain native method calls are not seamlessly portable across platforms. In this paper, we describe a new approach to transparently run Java applications containing native method calls to one ISA (instruction set architecture) on a different ISA's Java platform. This approach operates within the same operating system process that executes the application but with the support of a dynamic translator. This paper describes the technical challenges and solutions of such an in-process implementation within a production Java Virtual Machine (JVM). These include interfacing the JVM with a dynamic translator to support native calls to a different ISA, pursuing a JVM-independent implementation, enhancing the dynamic translator to support shared libraries in addition to executables, marshalling arguments across ISA boundaries, and providing full support for all Java features such as multi-threading. The paper presents performance results for an end-user application, showing our approach to be 2-3 times faster than other approaches.
Production of docosahexaenoic acid byThraustochytrium roseum (1994)

When three Thraustochytrium stains were cultivated in liquid media containing 2.5% starch and 0.2% yeast extract, initial pH 6.0, with shaking under fluorescent light for five days at 25 degrees C, similar biomass yields were observed (9.7-10.3 g L-1). Contents of docosahexaenoic acid (DHA) in biomass varied: 0.15, 3.55 and 6.40% w/w for T. striatum ATCC 24473. T. aureum ATCC 34304 and T. roseum ATCC 28210, respectively. In further studies, T. roseum produced a maximum titer of 0.85 g of DHA per liter of culture broth. The DHA content of total lipids ranged from 46-49% w/w.
Fractal multiband antennabased on the Sierpinski gasket (1996)

Experimental and computed results show a multiband behaviour over five bands for the new fractal Sierpinski antenna. Such a behaviour is based on the self-similarity properties of the antenna&apos;s fractal shape, which might open an alternative way for designing new multiband and frequency independent antennas.
Quantum associative memory with exponential capacity (2002)

Quantum computation uses microscopic quantum level effects to perform computational tasks and has produced results that in some cases are exponentially faster than their classical counterparts by taking advantage of quantum parallelism. The unique characteristics of quantum theory may also be used to create a quantum associative memory with a capacity exponential in the number of neurons. This paper covers necessary high-level quantum mechanical ideas and introduces a simple quantum associative memory. Furthermore, it provides discussion, empirical results and directions for future work.
One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (1997)

A total of 1,025,415 bases of nucleotide sequence, including the entire human immunoglobulin lambda gene locus has been determined. This is the largest contiguous human DNA sequence ever published. The sequence data revealed the organization of 36 potentially active V lambda gene segments, 33 pseudogene segments, and seven J lambda-C lambda gene segments. Among these 69 functional or nonfunctional V lambda gene segments, 32 were newly discovered. These V lambda gene segments are located within five gene-rich clusters and are divided into five clans based on sequence identity. Five potentially active nonimmunoglobulin genes were also detected within the lambda gene locus, and two other genes were observed in the upstream region. Sequence organization suggests that large DNA duplications diversified the germ-line repertoire of the V lambda gene segments.