gebhart/patrepeval huggingface dataset:
TV Content Recommender System (2000)

The plethora of content available to the consumer has become overwhelming. Increasing amounts of information are being disseminated through terrestrial broadcast, satellite, and cable leading to an information overload. Common modes of searching for TV programs currently in existence include: TV-guide, PreVue channel and rudimentary search tools available through satellite dish TV programming service. These tools are general-purpose in nature and are not specifically tailored to the individual viewer’s taste. Towards that end we advance in this paper a recommender system that searches for TV programs based on their likes/dislikes through implicit personalization techniques.
A model of a secure intelligent trade agent (2001)

In this paper, we propose a model of a secure intelligent trade agent. In building this agent, we adapt our agent to use with a secure and efficient electronic cash (executable digital-cash, x-cash) [1] to enable agents to carry funds and make payments on-site without running the risk of “pick-pocketing”. It is a means of binding an offer to accompanying goods or payment, enabling the processes of searching and paying to be unified. The result is a mechanism by which electronic trades can occur in a highly distributed setting with strong security guarantees. This model provides an interface by which users obtain the certificates from the bank and authorizing them to make payments. The user can login to the agent repository (AR) for issuing offer programs ω. The program ω along with the certificate constitutes a piece of x-cash. An agent together with the executable digital cash (x-cash) which represents a buyer will be sent across the Internet via “asymmetric proxy reencryption protocol [2,9], executing methods (ω) on a number of merchant’s server (on remote server systems). It takes as input some item, and outputs the amount which the buyer is willing to pay for that item. If the
Pulsus alternans (1993)

Journal Article Pulsus alternans Get access Max J Lab, Max J Lab Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, United Kingdom — British Heart Foundation Cardiac Arrhythmia Research Group, Department of Physiology: M J Lab; Department of Medicine: W A Seed. Correspondence to Dr Lab. Search for other works by this author on: Oxford Academic PubMed Google Scholar W Anthony Seed W Anthony Seed Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, United Kingdom — British Heart Foundation Cardiac Arrhythmia Research Group, Department of Physiology: M J Lab; Department of Medicine: W A Seed. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 8, August 1993, Pages 1407–1412, https://doi.org/10.1093/cvr/27.8.1407 Published: 01 August 1993 Article history Received: 23 December 1992 Accepted: 08 February 1993 Published: 01 August 1993
An Efficient TVL1 Algorithm for Deblurring Multichannel Images Corrupted by Impulsive Noise (2009)

We extend the alternating minimization algorithm recently proposed in [Y. Wang, J. Yang, W. Yin, and Y. Zhang, SIAM J. Imag. Sci., 1 (2008), pp. 248–272]; [J. Yang, W. Yin, Y. Zhang, and Y. Wang, SIAM J. Imag. Sci., 2 (2009), pp. 569–592] to the case of recovering blurry multichannel (color) images corrupted by impulsive rather than Gaussian noise. The algorithm minimizes the sum of a multichannel extension of total variation and a data fidelity term measured in the $\ell_1$-norm, and is applicable to both salt-and-pepper and random-valued impulsive noise. We derive the algorithm by applying the well-known quadratic penalty function technique and prove attractive convergence properties, including finite convergence for some variables and q-linear convergence rate. Under periodic boundary conditions, the main computational requirements of the algorithm are fast Fourier transforms and a low-complexity Gaussian elimination procedure. Numerical results on images with different blurs and impulsive noise are presented to demonstrate the efficiency of the algorithm. In addition, it is numerically compared to the least absolute deviation method [H. Y. Fu, M. K. Ng, M. Nikolova, and J. L. Barlow, SIAM J. Sci. Comput., 27 (2006), pp. 1881–1902] and the two-phase method [J. F. Cai, R. Chan, and M. Nikolova, AIMS J. Inverse Problems and Imaging, 2 (2008), pp. 187–204] for recovering grayscale images. We also present results of recovering multichannel images.
Structural comparison of urease and a GroEL analog from Helicobacter pylori (1992)

Electron microscopy of purified protein preparations indicated that Helicobacter pylori urease consisted of circular particles that are 13 nm in diameter, some of which showed indications of threefold rotational symmetry. A GroEL analog of H. pylori (Hp60K) appeared as a disc-shaped molecule with a diameter similar to that of urease but possessed sevenfold rotational symmetry. In a side-view projection, Hp60K appeared as two or four discs stacked side by side.
An integrated high resolution CMOS timing generator based on an array of delay locked loops (1996)

This paper describes the architecture and performance of a new high resolution timing generator used as a building block for time-to-digital converters (TDC) and clock alignment functions. The timing generator is implemented as an array of delay locked loops. This architecture enables a timing generator with subgate delay resolution to be implemented in a standard digital CMOS process. The TDC function is implemented by storing the state of the timing generator signals in an asynchronous pipeline buffer when a hit signal is asserted. The clock alignment function is obtained by selecting one of the timing generator signals as an output clock. The proposed timing generator has been mapped into a 1.0 /spl mu/m CMOS process and an r.m.s. error of the time taps of 48 ps has been measured with a bin size of 0.15 ns. Used as a TDC device, an r.m.s. error of 76 ps has been obtained, A short overview of the basic principles of major TDC and timing generator architectures is given to compare the merits of the proposed scheme to other alternatives.
The feasibility of direct adductor canal block (DACB) as a part of periarticular injection in total knee arthroplasty (2020)

Abstract Background Adductor canal block (ACB) is one of the preferred methods of analgesia in total knee arthroplasty (TKA). However, conventionally its use is time-consuming, requires ultrasound guidance, a trained anaesthesia team and adherence to strict asepsis by members of the allied teams. This study was done to assess the feasibility and safety of direct adductor canal block (DACB) as a part of surgeon-administered periarticular infiltration. Materials and methods Thirty computed tomography (CT) angiography films of the patients were retrospectively reviewed. The trajectory of the needle placement for a DACB in relation to the target region of the adductor block was determined. Fourteen knees in seven cadavers, were dissected through a medial parapatellar approach to perform TKA. After administering the DACB using the technique based on CT data, dissection was carried out to ascertain the correct placement of the dye by visualising the stained areas. Results The angle of approach in the coronal plane from the entry point to the medial high point and to the adductor hiatus was 10.2° (8−14°) and 6° (3.8−11°), respectively. The angle of approach in the sagittal plane from the entry point to the medial high point and to the adductor hiatus was 7° (5−10.5°) and 29° (19−43°), respectively. In all the 14 cadaveric knees, we confirmed the correct placement of the methylene blue dye as demonstrated by the staining of the adductor canal. Conclusion The study demonstrates the feasibility of the DACB. This surgeon-driven technique is likely to reduce the cost of the procedure, reduce operating room time and also eliminate the risks of surgical-site contamination.
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. (1994)

AP-1 transcriptional activity is stimulated by the transformation promoters phorbol 12-myristate 13-acetate ("12-O-tetradecanoylphorbol 13-acetate," TPA) and epidermal growth factor (EGF) in promotion-sensitive (P+) but not in promotion-resistant (P-) JB6 mouse epidermal cell lines. Although TPA stimulates expression of the jun and fos family genes, only c-jun expression shows higher elevation in P+ cells than in P- cells. The present study tests the hypothesis that induced AP-1 activity is required for tumor promoter-induced transformation in JB6 P+ cells. Both retinoic acid and the glucocorticoid fluocinolone acetonide inhibited basal and TPA-induced AP-1 activities that were tested with a stromelysin promoter-chloramphenicol acetyltransferase reporter gene in P+ cells. Since both retinoic acid and fluocinolone acetonide are active in inhibiting TPA-induced anchorage-independent transformation of P+ cells in the dose range that blocks TPA-induced AP-1 activity, their antipromoting effects may occur through inhibition of AP-1 activity. To test the hypothesis with a more specific inhibitor, stable clonal transfectants of P+ cells expressing dominant negative c-jun mutant encoding a transcriptionally inactive product were analyzed. All transfectants showed a block in TPA and EGF induction of AP-1 activity. All transfectants also showed inhibition of TPA-induced transformation, and most transfectants showed a block in EGF-induced transformation. These results indicate that AP-1 activity is required for TPA- or EGF-induced transformation. This work demonstrates that a specific block in induced AP-1 activity inhibits tumor promoter-induced transformation.
Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies. (1980)

Eighteen mouse monoclonal antibodies were selected for reactivity with cell surface antigens of the immunizing human melanoma cell line SK-MEL-28. Six distinct antigenic systems were defined by direct serological assays and absorption tests with a panel of 41 cell lines derived from normal and malignant human tissues. Biochemical analysis indicated that two of the antigens are glycoproteins with molecular sizes of 95,000 and 150,000 daltons (gp95 and gp150). Two other antigenic systems (O5 and the R24 group) are associated with heat-stable molecules having the characteristics of glycolipids. The remaining two antigens (M19 and R8) are heat labile, but molecular characterization has not been possible. Each of the antigenic systems has a distinctive pattern of distribution on various cell types, varying from a broad representation to a more restricted occurrence. O5 appears to be a species antigen, being present on virtually every human cell type tested. gp95, gp150, M19, and R8 are found on a characteristic proportion of melanomas, astrocytomas, and epithelial cancers and on normal kidney cells. The antigen defined by the R24 antibody has the most restricted distribution of all. Reactivity is found with melanomas and astrocytomas, whereas epithelial cell types, fibroblasts, and cells of hematopoietic origin lack R24. Although occurrence of gp95, gp150, M19, and R8 distinguishes a small subset of melanomas not expressing these antigens, R24 is found on all melanoma cells.
Electric behavior of low back muscles during lumbar pelvic rhythm in low back pain patients and healthy controls. (1991)

All functional phases seen in raw IM EMG were also shown in surface RMS EMG. Surface RMS EMG pattern seems to yield more information from activity level than IM EMG pattern. The RMS EMG patterns of back pain patients differed from those of controls as follows: (1) There was clearly noticeable activity during standing in back pain patients. (2) There was only a partial decrease of EMG activity after flexion in back pain patients with current pain. (3) The ratio of mean reached at maximal activity level during extension and flexion was less in patients (1.8, SD = 0.5, p less than .001) than able-bodied controls (3.2, SD = 0.8). (4) Segmental differences were observed in IM EMG activities in patients having hypermobility in bending x-ray. (5) Large peak potentials occurred during movements in patients having segmental hypermobility. THE RESULTS indicate that averaged surface recording is a valuable tool in the investigation of dynamic spine functions in back pain patients.
Progressive Retropalatal Narrowing Preceding Obstructive Apnea (1998)

Pharyngeal occlusion during obstructive apnea is thought to be an inspiratory-related event; however, occlusion also occurs in the absence of negative intrathoracic pressure. We hypothesized that inspiratory-related pharyngeal occlusion would be preceded by significant expiratory narrowing. Eight sleeping patients with obstructive apnea were studied. Pharyngeal caliber, airflow, and esophageal pressure (Pes) were simultaneously monitored during three to four consecutive breaths preceding occlusion (between 3 and 22 events were studied per subject). Relative changes in retropalatal airway cross-sectional area (CSA) were determined from fiberoptic images (five frames per second) normalized to the maximum CSA. During inspiration, CSA was significantly reduced only during the breath immediately preceding the apnea (Group mean CSA +/- SEM: 51 +/- 8% at the start of inspiration compared with 37 +/- 8% at midinspiration). During expiration, for all breaths there was an initial significant increase in CSA compared with the nadir CSA during the preceding inspiration (CSA: breath-3, 57 +/- 10% to 79 +/- 3%; breath-2, 59 +/- 8% to 76 +/- 4%; breath-1, 37 +/- 8% to 64 +/- 8%), followed by a significant narrowing at end-expiration compared with the peak CSA during that expiration (CSA: breath-3, 79 +/- 3% to 62 +/- 6%; breath-2, 76 +/- 4% to 50 +/- 10%; breath-1, 64 +/- 8% to 36 +/- 10%). Occlusion occurred at a pressure significantly less than that generated during the previous unoccluded breath (Pes: breath-1, -10.8 +/- 2.9 cm H2O; occlusion, -8.2 +/- 1.9 cm H2O). These results show that expiratory narrowing produced a significant reduction of CSA at end-expiration prior to obstructive apnea.
Parkinson's disease: 10 years of progress, 1997–2007 (2010)

Many people with Parkinson's disease (PD) and their family members ask their physicians "What is happening in research on Parkinson's disease? Is there anything new?" As the initial speaker at the symposium organized by the Parkinson's Disease Foundation in celebration of its 50th anniversary, I sought to address these questions, focusing on research published between the years 1997 and 2007. I cataloged the advances I considered most important in the field, recognizing my viewpoint is a subjective one and most likely differs from similar listings that others would put together. Space limitation allows me to discuss only a tiny fraction of the remarkable new findings that have been discovered during this 10-year span. Nevertheless, I expect the readers of this summation of advances in the field to be as impressed as I am on the wealth, breadth, and excitement stirring in the field of PD research. Included in this overview are highlights in both laboratory science and clinical science of PD research. In the former category are advances in knowledge on the genetics of PD; potential etiologic and pathogenic causes, especially the better understanding of endogenous factors within dopaminergic neurons; pathologic changes including deposition of alpha-synuclein aggregates; and the consequences of altered alpha-synuclein on the degradation of proteins by both the ubiquitin-proteasomal pathway and the lysosome. Clinical science has also been very active and impressively productive with important clinical advances. In this category are new information on the epidemiology of PD, including awareness of additional factors (besides smoking) that might slow the onset and worsening of PD, such as caffeine and urate; neuroimaging with positron emission tomography and single photon emission tomography; keener awareness of nonmotor features of PD and their impact on quality of life for the persons with PD and their family; recognition of behavioral complications of medications utilized to treat PD, such as impulse control problems; appreciation of the natural history of PD with the increasing impairments as the disease relentlessly worsens over time; the many controlled clinical trials attempting to slow the progression of the disease and to provide new symptomatic therapies; and surgical approaches to alleviate symptoms and progression, including cellular and gene therapy as well as deep brain stimulation.
A case for flash memory ssd in enterprise database applications (2008)

Due to its superiority such as low access latency, low energy consumption, light weight, and shock resistance, the success of flash memory as a storage alternative for mobile computing devices has been steadily expanded into personal computer and enterprise server markets with ever increasing capacity of its storage. However, since flash memory exhibits poor performance for small-to-moderate sized writes requested in a random order, existing database systems may not be able to take full advantage of flash memory without elaborate flash-aware data structures and algorithms. The objective of this work is to understand the applicability and potential impact that flash memory SSD (Solid State Drive) has for certain type of storage spaces of a database server where sequential writes and random reads are prevalent. We show empirically that up to more than an order of magnitude improvement can be achieved in transaction processing by replacing magnetic disk with flash memory SSD for transaction log, rollback segments, and temporary table spaces.
Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation (2010)

The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function-blocking antibodies in the established keratin 14 (K14)-VEGF-A transgenic (Tg) mouse model of chronic cutaneous inflammation. Although treatment with an anti-VEGFR-2 antibody inhibited skin inflammation, epidermal hyperplasia, inflammatory infiltration, and angiogenesis, systemic inhibition of VEGFR-3, surprisingly, increased inflammatory edema formation and inflammatory cell accumulation despite inhibition of lymphangiogenesis. Importantly, chronic Tg delivery of the lymphangiogenic factor VEGF-C to the skin of K14-VEGF-A mice completely inhibited development of chronic skin inflammation, epidermal hyperplasia and abnormal differentiation, and accumulation of CD8 T cells. Similar results were found after Tg delivery of mouse VEGF-D that only activates VEGFR-3 but not VEGFR-2. Moreover, intracutaneous injection of recombinant VEGF-C156S, which only activates VEGFR-3, significantly reduced inflammation. Although lymphatic drainage was inhibited in chronic skin inflammation, it was enhanced by Tg VEGF-C delivery. Together, these results reveal an unanticipated active role of lymphatic vessels in controlling chronic inflammation. Stimulation of functional lymphangiogenesis via VEGFR-3, in addition to antiangiogenic therapy, might therefore serve as a novel strategy to treat chronic inflammatory disorders of the skin and possibly also other organs.
Sequence and expression of the genes for HPr (ptsH) and enzyme I (ptsI) of the phosphoenolpyruvate-dependent phosphotransferase transport system from Streptococcus mutans (1994)

We report the sequencing of a 2,242-bp region of the Streptococcus mutants NG5 genome containing the genes for ptsH and ptsI, which encode HPr and enzyme I (EI), respectively, of the phosphoenolpyruvate-dependent phosphotransferase transport system. The sequence was obtained from two cloned overlapping genomic fragments; one expresses HPr and a truncated EI, while the other expresses a full-length EI in Escherichia coli, as determined by Western immunoblotting. The ptsI gene appeared to be expressed from a region located in the ptsH gene. The S. mutans NG5 pts operon does not appear to be linked to other phosphotransferase transport system proteins as has been found in other bacteria. A positive fermentation pattern on MacConkey-glucose plates by an E. coli ptsI mutant harboring the S. mutans NG5 ptsI gene on a plasmid indicated that the S. mutans NG5 EI can complement a defect in the E. coli gene. This was confirmed by protein phosphorylation experiments with 32P-labeled phosphoenolpyruvate indicating phosphotransfer from the S. mutans NG5 EI to the E. coli HPr. Two forms of the cloned EI, both truncated to varying degrees in the C-terminal region, were inefficiently phosphorylated and unable to complement fully the ptsI defect in the E. coli mutant. The deduced amino acid sequence of HPr shows a high degree of homology, particularly around the active site, to the same protein from other gram-positive bacteria, notably, S. salivarius, and to a lesser extent with those of gram-negative bacteria. The deduced amino acid sequence of S. mutans NG5 EI also shares several regions of homology with other sequenced EIs, notably, with the region around the active site, a region that contains the only conserved cystidyl residue among the various proteins and which may be involved in substrate binding.
Remote Ischemic Preconditioning Improves Outcome at 6 Years After Elective Percutaneous Coronary Intervention (2013)

URL: http://www.ukcrn.org.uk. Unique identifier: UKCRN 4074.
Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065 (2009)

The natural antibiotics CC‑1065 and the duocarmycins are highly cytotoxic compounds which however are not suitable for cancer therapy due to their general toxicity. We have developed glycosidic prodrugs of seco-analogues of these antibiotics for a selective cancer therapy using conjugates of glycohydrolases and tumour-selective monoclonal antibodies for the liberation of the drugs from the prodrugs predominantly at the tumour site. For the determination of structure activity relationships of the different seco-drugs, experiments addressing their interaction with synthetic DNA were performed. Using electro-spray mass spectrometry and high performance liquid chromatography, the experiments revealed a correlation of the stability of these drugs with their cytotoxicity in cell culture investigations. Furthermore, it was shown that the drugs bind to AT-rich regions of double-stranded DNA and the more cytotoxic drugs induce DNA fragmentation at room temperature in several of the selected DNA double-strands. Finally, an explanation for the very high cytotoxicity of CC-1065, the duocarmycins and analogous drugs is given.