gebhart/patrepeval huggingface dataset:
Neural regulation of glucagon-like peptide-1 secretion in pigs (2004)

Glucagon-like peptide (GLP)-1 is secreted rapidly from the intestine postprandially. We therefore investigated its possible neural regulation. With the use of isolated perfused porcine ileum, GLP-1 secretion was measured in response to electrical stimulation of the mixed, perivascular nerve supply and infusions of neuroactive agents alone and in combination with different blocking agents. Electrical nerve stimulation inhibited GLP-1 secretion, an effect abolished by phentolamine. Norepinephrine inhibited secretion, and phentolamine abolished this effect. GLP-1 secretion was stimulated by isoproterenol (abolished by propranolol). Acetylcholine stimulated GLP-1 secretion, and atropine blocked this effect. Dimethylphenylpiperazine stimulated GLP-1 secretion. In chloralose-anesthetized pigs, however, electrical stimulation of the vagal trunks at the level of the diaphragm had no effect on GLP-1 or GLP-2 and weak effects on glucose-dependent insulinotropic peptide and somatostatin secretion, although this elicited a marked atropine-resistant release of the neuropeptide vasoactive intestinal polypeptide to the portal circulation. Thus GLP-1 secretion is inhibited by the sympathetic nerves to the gut and may be stimulated by intrinsic cholinergic nerves, whereas the extrinsic vagal supply has no effect.
A 0.78mW/cm<sup>2</sup> autonomous thermoelectric energy-harvester for biomedical sensors (2015)

A thin-film array-based thermoelectric energy-harvester (TEH) is assembled in a 0.83cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> footprint and attached to a power management unit integrated in 65nm CMOS. A single-inductor topology with analog maximum-power-point tracking leads to a 68% peak end-to-end efficiency and <;20ms tracking time. A 645μW regulated output power (effective 3.5K) is harvested in-vivo from a rat implanted with our TEH, to demonstrate true energy autonomy in real environment while achieving a 7.9x improvement in regulated power density. The autonomous operation is measured down to 65mV TEH input.
Scaling laws for electrical contact resistance with dissimilar materials (2010)

This paper attempts to quantify the effects of contaminants on electrical contact resistance. Based on an idealized model, simple and explicit scaling laws for the electrical contact resistance with dissimilar materials are constructed. The model assumes arbitrary resistivity ratios and aspect ratios in the current channels and their contact region, for both Cartesian and cylindrical geometries. The scaling laws have been favorably tested in several limits, and in sample calculations using a numerical simulation code. From the scaling laws and a survey of the huge parameter space, some general conclusions are drawn on the parametric dependence of the contact resistance on the geometry and on the electrical resistivity in different regions.
American Psychiatric Electronic Library (1995)

This article describes the American Psychiatric Electronic Library, a full-text database containing eleven psychiatric journals, five basic textbooks, practice guidelines, and the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Information about contents, hardware and software requirements, searching capability, user support, and cost is provided.
Heterogeneity of Mouse Spleen Dendritic Cells: In Vivo Phagocytic Activity, Expression of Macrophage Markers, and Subpopulation Turnover (1998)

In the normal mouse spleen, two distinct populations of dendritic cells (DC) are present that differ in microanatomical location. The major population of marginal DC is found in the "marginal zone bridging channels" and extends into the red pulp. The interdigitating cells (IDC) are localized in the T cell areas in the white pulp. The aim of the present study was to characterize these two splenic DC populations with regard to their phenotype, in vivo phagocytic function, and turnover. Both marginal DC and IDC are CD11c+ and CD13+, but only IDC are NLDC-145+ and CD8alpha+. Notably, both populations, when freshly isolated, express the macrophage markers F4/80, BM8, and Mac-1. To study the phagocytic capacity of these cells, we employed the macrophage "suicide" technique by injecting liposomes loaded with clodronate i.v. Marginal DC, but not IDC, were eliminated by this treatment. Phagocytosis of DiI-labeled liposomes by DC confirmed this finding. The two DC populations differed significantly with regard to their turnover rates, as studied in a transgenic mouse model of conditional depletion of DC populations with high turnover. In these mice, marginal DC were completely eliminated, but the IDC population remained virtually intact. From these data we conclude that the marginal DC population has a high turnover, in contrast to the IDC population. Taken together, the present results indicate that marginal DC and IDC represent two essentially distinct populations of DC in the mouse spleen. They differ not only in location, but also in phenotype, phagocytic ability, and turnover.
The cellular response to hypoxia: tuning the system with microRNAs (2010)

Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also controlled by specific microRNAs and, in turn, controls the expression of other microRNAs, which fine-tune adaptation to low oxygen tension. In this issue of the JCI, Ghosh and colleagues identify a unique microRNA in hypoxic endothelial cells, miR424, that promotes HIF-1 stabilization and angiogenesis. The actions of this microRNA are considered in the context of the complex interactions that act to ensure optimal endothelial adaptation to this critical environmental condition.
Development of a novel hearing-aid for the profoundly deaf using bone-conducted ultrasonic perception: Evaluation of transposed modulation (2013)

Bone-conducted ultrasound (BCU) is perceived even by the profoundly sensorineural deaf. A novel hearing aid using the perception of amplitude-modulated BCU (BCU hearing aid: BCUHA) has been developed. However, there is room for improvement particularly in terms of articulation and sound quality. BCU speech is accompanied by a strong high-pitched tone and contain some distortion. In this study, transposed modulation, that can be expected to reduce the high-pitched tone was newly employed as a modulation method in the BCUHA, and its resulting articulation, intelligibility and sound quality were evaluated. The results showed that transposed modulation showed nearly equal articulation and intelligibility scores to and better sound quality than the existing method, DSB-TC modulation. These results provide useful information for further development of the BCUHA.
Quinazolines and 1,4-benzodiazepines. L. Ring contraction of 4-hydroxy-5-phenyltetrahydro-1,4-benzodiazepines to tetrahydroquinoxalines (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuinazolines and 1,4-benzodiazepines. L. Ring contraction of 4-hydroxy-5-phenyltetrahydro-1,4-benzodiazepines to tetrahydroquinoxalinesA. Walser, G. Silverman, R. Ian Fryer, and Leo H. SternbachCite this: J. Org. Chem. 1971, 36, 9, 1248–1251Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://doi.org/10.1021/jo00808a018Request reuse permissionsArticle Views202Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (560 KB) Get e-Alertsclose Get e-Alerts
Mitochondrial genome organization and expression associated with cytoplasmic male sterility in sunflower (Helianthus annuus) (1991)

A comparative investigation of the organization and expression of the mitochondrial genome in fertile and cytoplasmic male sterile (CMS) sunflower (Helianthus annuus) has been undertaken. A region of mitochondrial genome variation between the two phenotypes has been located in the 3' flanking region of the gene encoding the alpha subunit of the F1 ATPase (atpA). Physical mapping and sequence analysis have been used to show that a rearrangement involving an inversion and an insertion has occurred immediately downstream of the atpA coding region in the mitochondrial DNA from sterile sunflower. This rearrangement has resulted in the creation of a new open reading frame (ORFc) which is co-transcribed with atpA in sterile sunflower. In organello labelling of mitochondrial translation products from the two types of sunflower shows that a 15 kDa protein is synthesized by the mitochondria from sterile sunflower but not by those from fertile plants. The ORFc sequence could encode this 15 kDa protein which may be causally related to the CMS phenotype.
Exceptional H2 Saturation Uptake in Microporous Metal−Organic Frameworks (2006)

Saturation H2 uptake in a series of microporous metal-organic frameworks (MOFs) has been measured at 77 K. Saturation pressures vary between 25 and 80 bar across the series, with MOF-177 showing the highest uptake on a gravimetric basis (7.5 wt %) and IRMOF-20 showing the highest uptake on a volumetric basis at 34 g/L. These results demonstrate that maximum H2 storage capacity in MOFs correlates well to surface area, and that feasible volumetric uptakes can be realized even in highly porous materials.
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel (2001)

Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a dose-limiting painful peripheral neuropathy in a clinically significant number of cancer patients. Prior work has demonstrated paclitaxel-induced neurodegeneration and sensory loss in laboratory rodents. We describe here an experimental paclitaxel-induced painful peripheral neuropathy. Adult male rats were given four intraperitoneal injections on alternate days of vehicle or 0.5, 1.0, or 2.0 mg/kg of paclitaxel (Taxol). Behavioral tests for pain using mechanical and thermal stimuli applied to the tail and hind paws, and tests for motor performance, were taken before, during and after dosing for 22-35 days. All three doses of paclitaxel caused heat-hyperalgesia, mechano-allodynia, mechano-hyperalgesia, and cold-allodynia, but had no effect on motor performance. Neuropathic pain began within days and lasted for several weeks. We did not detect any dose-response relationship. Tests at the distal, mid, and proximal tail failed to show evidence of a length-dependent neuropathy. Vehicle control injections had no effect on any measure. No significant systemic toxicities were noted in the paclitaxel-treated animals. Light-microscopic inspection of the sciatic nerve (mid-thigh level), L4-L5 dorsal root ganglia, and dorsal and ventral roots, and the gray and white matter of the L4-L5 spinal cord, showed no structural abnormalities. Electron microscopic examination of the sciatic nerve (mid-thigh level) and the L4-L5 dorsal root ganglia and dorsal horns demonstrated no degeneration of myelinated and unmyelinated axons in the sciatic nerve and roots, but revealed endoneurial edema. This model may be useful in understanding a significant source of pain in cancer patients, and in finding ways to avoid the neurotoxicity that limits paclitaxel therapy.
Blocking IDO activity to enhance anti-tumor immunity (2012)

Tumors express potentially immunogenic antigens, yet the immune response to these antigens is typically profoundly suppressed. Patients with established tumors behave as if they were functionally tolerant to any antigens associated with the tumor. This tolerance reflects a process of active immune suppression elicited by the tumor, and represents a critical barrier to successful antitumor immunotherapy. Indoleamine 2,3-dioxygenase (IDO) is a natural immunoregulatory mechanism contributes to immune suppression and tolerance in a variety of settings. In tumor-bearing hosts, animal models suggest that tumor-induced IDO helps create a tolerogenic milieu within the tumor and the associated tumor-draining lymph nodes. IDO directly suppresses the proliferation and differentiation of effector T cells, and markedly enhances the suppressor activity of regulatory T cells (Tregs). Together, these effects contribute to the inability of the immune system to respond effectively to tumor antigens. Treatment of tumor-bearing animals with IDO-inhibitor drugs enhances anti-tumor immune responses, and IDOinhibitors are synergistic with a variety of chemotherapeutic drugs, anti-tumor vaccines and other immunotherapy. Strategies to pharmacologically inhibit IDO may thus enhance immune-mediated responses following conventional chemotherapy, and may be synergistic with other forms of immunotherapy.
Experimental Autoimmune Thyroiditis Induced by Thyroglobulin-Pulsed Dendritic Cells (1999)

Dendritic cells (DCs), which are the most effective professional antigen-presenting cells (APCs), initiate and regulate immune responses. In this report, we examine the role of DCs in the induction of autoimmune thyroiditis. Experimental autoimmune thyroiditis (EAT) induced by immunization with thyroglobulin (Tg) plus adjuvant is considered to be an animal model of autoimmune thyroiditis, and is categorized as a T cell-mediated autoimmune disease. To examine the contribution of DCs to EAT, naive DCs were purified from high responder B10BR mice and pulsed with various concentrations of porcine Tg (pTg). These pTg-pulsed DCs were transferred without adjuvant to syngenic BIOBR mice to induce EAT. Mice that had received pTg-pulsed DCs showed thyroiditis, and the degree of thyroiditis induced was positively correlated to the amounts of pTg used for the incubation (pulsing) of DCs. The severity of thyroiditis was also correlated to the amounts of anti-pTg IgG2a antibodies and IFN-gamma in the recipient sera, but not to IL-4 or IL-10, indicating that Th1 cells are mainly activated by pTg-pulsed DCs and attributable to the pathogenesis of EAT.
Low Levels of Circulating Adiponectin Are Associated with Multiple Myeloma Risk in Overweight and Obese Individuals (2016)

The association between obesity and multiple myeloma risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals. To prospectively evaluate multiple myeloma risk in relation to adiponectin levels overall and stratified by body mass index and other characteristics, we conducted a pooled investigation of pre-diagnosed peripheral blood samples from 624 multiple myeloma cases and 1,246 individually matched controls from seven cohorts participating in the Multiple Myeloma Cohort Consortium. Analysis of circulating analyte levels measured by ELISA revealed that higher total adiponectin levels were associated with reduced multiple myeloma risk overall [highest quartile vs. lowest: OR, 0.64; 95% confidence interval (CI) 0.47-0.85; Ptrend = 0.001]. This association was apparent among cases diagnosed six or more years after blood collection (OR, 0.60; 95% CI, 0.40-0.90; Ptrend = 0.004) and was similar in magnitude for men and women (OR, 0.59 and 0.66, respectively). Interestingly, we observed strong associations among subjects who were overweight (OR, 0.41; 95% CI, 0.26-0.65) or obese (OR, 0.41; 95% CI, 0.17-0.98) but not among those with normal weight (OR, 1.20; 95% CI, 0.73-2.00; overweight/obese vs. normal weight, Pinteraction = 0.04). Our findings provide the strongest epidemiologic evidence to date that adiponectin protects against multiple myeloma development, particularly among overweight and obese individuals, and offer a method for risk assessment in this susceptible population of heavier patients. Cancer Res; 76(7); 1935-41. ©2016 AACR.
Continuous-wave operation of far-infrared quantum cascade lasers (2002)

Continuous-wave operation of a terahertz quantum cascade laser is reported. Optical output powers ranging from 410 µW at 10 K to 124 µW at 35 K, at an emission wavelength of 66 µm are obtained.
Highly performed PCB embedded inductors using inverted-patterned ground structure (2010)

In this paper, PCB embedded circular-stacked spiral inductors with the inverted-patterned ground (IPG) plane were designed, fabricated, and characterized in order to reduce their sizes and improve their quality factors. IPG structure was applied to reduce the induced loop current loss of the inductor. Interdependency of the line width and space of IPG plane on their performance characteristics are also investigated. The embedded inductor with four turns (1<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> layer - 2 turns and 2<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> layer - 2 turns stacked), the size of 1 × 1 mm<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup>, and IPG plane exhibited inductance of 9.68 nH, quality factor of 71.5 at 1.5 GHz, and self resonant frequency of 3.98 GHz, respectively. The quality factor of the inductor with IPG plane was improved by approximately 20 % in comparison to that of the inductor with the solid ground plane. Moreover, when spaces of IPG plane were double than line widths of inductors, their quality factors were highly optimized for the best RF performances. The PCB embedded high Q inductors with IPG plane might be useful for advanced RF/wireless systems since they have excellent performance characteristics, small size, and light volume.
ICMP Security Failures Messages (1999)

This document specifies ICMP messages for indicating failures when using IP Security Protocols (AH and ESP).
dhSegment : A generic deep-learning approach for document segmentation (2018)

DHLAB
Is erythropoietin a survival factor for red blood cells? (1996)

Recombinant human erythropoietin (rhuEPO) therapy has been reported to maintain corrected hematocrit values by increasing the length of red blood cell (RBC) survival. This article presents a controlled study that assessed the RBC survival before, during, and after termination of prolonged rhuEPO treatment of chronic hemodialysis patients. Two groups of 20 patients were studied. The hematocrit value of each patient was below 28 vol%. One group (Group A) was treated with rhuEPO for 1 yr and then treatment was stopped because of the unavailability of the drug. The second group (Group B) was treated for 2 yr. Epoetin beta was administered subcutaneously. The initial dose was 20 U per kg body weight three times weekly. Upon reaching the target hematocrit value of 30 to 35 vol%, the dose was individualized for each patient, to maintain target range. RBC survival was determined by the chromium-51 technique. In Group A, RBC survival was determined: (1) before, (2) at 12 months, and (3) 1 yr after cessation of rhuEPO treatment. In Group B, RBC survival was determined: (1) at 24 months of therapy, and (2) 1 yr after cessation of rhuEPO treatment. RBC survival increased significantly in both patient groups under rhuEPO treatment. After cessation of therapy, the RBC survival decreased to pretreatment values. During the correction period, reticulocyte counts increased significantly in both groups. Over the maintenance period, they slightly decreased, and after termination of rhuEPO therapy, they decreased to the pretreatment values. The results of this study could suggest the possibility that RBC survival was prolonged by the action of EPO on the erythroid progenitors, resulting in the production of RBC with improved viability.
Low-insertion-loss DP3T MMIC switch for dual-band cellular phones (1999)

We propose a new type of dual-pole triple-throw double heterojunction monolithic microwave integrated circuit (IC) switch for use in digital cellular phones. The IC we developed exhibits a low gate leakage current of 400 nA and an insertion loss as low as 0.4 dB, even at added power of 34 dBm at a frequency of 950 MHz. Measured P/sub 1 dB/ was about 36 dBm, and a low distortion of 65 dBc was also obtained.
Treatment‐Resistant Depression and Risk of Suicide (2013)

We evaluated whether treatment-resistant depression (TRD) as measured by the Massachusetts General Hospital (MGH) staging method was associated with suicide in a large U.S. health system. Data from the Veterans Health Administration and the National Death Index were used to conduct a case-control study of patients newly diagnosed with depression who received antidepressant treatment between 2003 and 2006. Suicide cases (N = 499) were matched with nonsuicide controls (N = 1994). Conditional logistic regression was used to assess whether MGH stage at time of suicide (or matched date) was associated with case status, adjusting for patient demographic characteristics, comorbidity, and service use. Results indicated 11.6% of suicide cases had MGH stage 3 or greater (indicating at least two antidepressant trials) compared to 6.4% of controls (p < .001). In adjusted analyses, suicide was not significantly more likely among patients with stage 3 or greater (OR 1.52; 95% CI: 0.98, 2.37) or stages 1.5-2.5 (OR 1.19; 95% CI: 0.91, 1.55) compared to patients with stage 1 or less (<10 weeks of antidepressant medication). Staging TRD using MGH criteria is unlikely to substantially improve suicide risk assessment of depressed patients beyond existing measures contained in health system records.
Tracking and counting moving people (2002)

The development of a system able to detect and track moving people is described. Given a sequence of time-varying images, the goal is to count the number of people crossing a counting line. A motion detection module first determines whether any person has entered the scene; a tracking module combining prediction and matching then follows people until they reach the counting line. The efficiency of the proposed approach is illustrated and assessed using sequences of images taken in a real environment.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>