gebhart/patrepeval huggingface dataset:
High-temperature sample holder for fast-atom bombardment mass spectrometry of molten materials (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-temperature sample holder for fast-atom bombardment mass spectrometry of molten materialsRobert J. DoyleCite this: Anal. Chem. 1987, 59, 3, 537–539Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/ac00130a039https://doi.org/10.1021/ac00130a039research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis by Chemoselective Ligation and Biological Evaluation of Novel Cell-Permeable PKC-ζ Pseudosubstrate Lipopeptides (2001)

The ability of lipopeptides to passively cross the cell membrane opens new opportunities for the intracellular delivery of bioactive peptides. However, the production of large series of cell-permeable lipopeptides is not trivial due to their generally low solubility. We have evaluated the possibility of associating the fatty acid to the functional cargo using generally applicable ligation chemistries. To this end, we have designed an amphiphilic shuttle in which arginine residues served to solubilize the lipid part in aqueous media, during both the assembly of the lipopeptide and the cellular assays. Our model peptide, the pseudosubstrate sequence of protein kinase C-zeta (PKC-zeta), was associated to the pentapeptide Gly-Arg-Gly-Arg-Lys(Pam)-NH2 through thiazolidine, thioether, disulfide, or hydrazone linkages. The cytoplasm import of the resulting constructs was monitored through the quantification of the apoptosis specifically induced by PKC-zeta inhibition. Our observations suggested the interest of this noninvasive cellular import method to modulate the activity of an intracytoplasmic pharmacological target and showed the influence of a non-amide link created between the functional peptide and the lipidic vector: optimal results, in terms of both specific activity and low basal cytotoxicity, were obtained with the thiazolidine ligation product.
Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding (2015)

The efficacy of therapeutic drugs is highly dependent on their optimal in vivo pharmacokinetics. Albumin conjugation is considered to be one of the most effective means of protracting the short lifespan of peptides and proteins. In this study, we proposed a novel platform for developing long lasting therapeutics by conjugating a small molecular albumin binding moiety, truncated Evans blue, to either peptides or proteins. Using the anti-diabetic peptide drug Exendin-4 as a model peptide, we synthesized a new long-acting Exendin-4 derivative (denoted as Abextide). Through complexation with albumin in situ, the biological half-life of Abextide was significantly extended. The hypoglycemic effect of Abextide was also improved remarkably over Exendin-4. Thus, Abextide has considerable potential to treat type 2 diabetes. This strategy as a general technology platform can be applied to other small molecules and biologics for the development of long-acting therapeutic drugs.
Effect of Garlic Oil and Four of its Compounds on Rumen Microbial Fermentation (2005)

Different concentrations (3, 30, 300, and 3000 mg/L of culture fluid) of garlic oil (GAR), diallyl sulfide (DAS), diallyl disulfide (DAD), allicin (ALL), and allyl mercaptan (ALM) were incubated for 24 h in diluted ruminal fluid with a 50:50 forage:concentrate diet (17.7% crude protein; 30.7% neutral detergent fiber) to evaluate their effects on rumen microbial fermentation. Garlic oil (30 and 300 mg/L), DAD (30 and 300 mg/L), and ALM (300 mg/L) resulted in lower molar proportion of acetate and higher proportions of propionate and butyrate. In contrast, at 300 mg/L, DAS only increased the proportion of butyrate, and ALL had no effects on volatile fatty acid proportions. In a dual-flow continuous culture of rumen fluid fed the same 50:50 forage:concentrate diet, addition of GAR (312 mg/L), DAD (31.2 and 312 mg/L), and ALM (31.2 and 312 mg/L) resulted in similar changes to those observed in batch culture, with the exception of the lack of effect of DAD on the proportion of propionate. In a third in vitro study, the potential of GAR (300 mg/L), DAD (300 mg/L), and ALM (300 mg/L) to decrease methane production was evaluated. Treatments GAR, DAD, and ALM resulted in a decrease in methane production of 73.6, 68.5, and 19.5%, respectively, compared with the control. These results confirm the ability of GAR, DAD, and ALM to decrease methane production, which may help to improve the efficiency of energy use in the rumen.
Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope (2001)

Diastereomerenreine und isotopenmarkierte 5′-O-DMT-nucleosid-3′-O-2-thio- und -oxo-4,4-„spiro“-pentamethylen-1,3,2-[18O]oxathiaphospholane wurden für die stereokontrollierte Synthese von P-chiralen, isotopenmarkierten Oligonucleotidphosphorothioaten und -phosphaten sowie von „chimeren“ PS18O/P18O-Oligomeren verwendet (siehe Schema), die ohne Verlust an Isotopenanreicherung verlief. DBU=1,8-Diazabicyclo[5.4.0]undec-7-en, DMT=4,4′-Dimethoxytrityl, ROH=3′-O-Acetylthymidin.
Insect neuropeptides: potential new insect control agents (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleInsect neuropeptides: potential new insect control agentsJulius J. Menn and Alexej B. BorkovecCite this: J. Agric. Food Chem. 1989, 37, 1, 271–278Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jf00085a062https://doi.org/10.1021/jf00085a062research-articleACS PublicationsRequest reuse permissionsArticle Views157Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Chemistry of Photodimers of Maleic and Fumaric Acid Derivatives.1 I. Dimethyl Fumarate Dimer (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Chemistry of Photodimers of Maleic and Fumaric Acid Derivatives.1 I. Dimethyl Fumarate DimerG. W. Griffin, A. F. Vellturo, and K. FurukawaCite this: J. Am. Chem. Soc. 1961, 83, 12, 2725–2728Publication Date (Print):June 1, 1961Publication History Published online1 May 2002Published inissue 1 June 1961https://pubs.acs.org/doi/10.1021/ja01473a029https://doi.org/10.1021/ja01473a029research-articleACS PublicationsRequest reuse permissionsArticle Views802Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Delegate: A Proxy Based Architecture for Secure Website Access from an Untrusted Machine (2006)

Performing sensitive online transactions using computers found in cybercafes and public libraries is risky. The untrusted nature of these machines creates a target rich environment. A simple keystroke logger, a common pay load of many viruses, records and transmits the secret information (e.g., passwords, credit card numbers, PIN numbers) entered into these machines. In addition, sophisticated malware can hijack a user's authenticated session to perform unauthorized transactions masquerading as the user. This paper presents Delegate, a proxy-based architecture that enables a user to access Web sites without disclosing personal information to untrusted machines. Delegate enforces rules at the proxy to detect and prevent session hijacking. This architecture leverages users' trusted mobile devices, e.g., cell phones, and requires no modification to Web servers or the untrusted machines. Delegate is designed to provide a balance between security and usability
Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks (2020)

Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs). However, MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASEs (MAP4Ks) are hardly explored. Here, we will give a comprehensive overview of what is known about plant MAP4Ks and highlight some outstanding questions associated with this largely uncharacterized class of kinases in plants.
Initial development of wireless acoustic emission sensor Motes for civil infrastructure state monitoring (2010)

The structural state of a bridge is currently examined by visual inspection or by wired sensor techniques, which are relatively expensive, vulnerable to inclement conditions, and time consuming to undertake. In contrast, wireless sensor networks are easy to deploy and flexible in application so that the network can adjust to the individual structure. Different sensing techniques have been used with such networks, but the acoustic emission technique has rarely been utilized. With the use of acoustic emission (AE) techniques it is possible to detect internal structural damage, from cracks propagating during the routine use of a structure, e.g. breakage of prestressing wires. To date, AE data analysis techniques are not appropriate for the requirements of a wireless network due to the very exact time synchronization needed between multiple sensors, and power consumption issues. To unleash the power of the acoustic emission technique on large, extended structures, recording and local analysis techniques need better algorithms to handle and reduce the immense amount of data generated. Preliminary results from utilizing a new concept called Acoustic Emission Array Processing to locally reduce data to information are presented. Results show that the azimuthal location of a seismic source can be successfully identified, using an array of six to eight poor-quality AE sensors arranged in a circular array approximately 200 mm in diameter. AE beamforming only requires very fine time synchronization of the sensors within a single array, relative timing between sensors of <TEX>$1{\mu}s$</TEX> can easily be performed by a single Mote servicing the array. The method concentrates the essence of six to eight extended waveforms into a single value to be sent through the wireless network, resulting in power savings by avoiding extended radio transmission.
Coordinated charging and discharging strategies for plug‐in electric bus fast charging station with energy storage system (2018)

Plug‐in electric bus (PEB) is an environmentally friendly mode of public transportation and PEB fast charging stations (PEBFCSs) play an essential role in the operation of PEBs. Under effective control, deploying an energy storage system (ESS) within a PEBFCS can reduce the peak charging loads and the electricity purchase costs. To deal with the (integrated) scheduling problem of (PEBs charging and) ESS charging and discharging, in this study, the authors propose an optimal real‐time coordinated charging and discharging strategy for a PEBFCS with ESS to achieve maximum economic benefits. According to whether the PEB charging loads are controllable, the corresponding mathematical models are, respectively, established under two scenarios, i.e. coordinated PEB charging scenario and uncoordinated PEB charging scenario. The price and lifespan of ESS, the capacity charge of PEBFCS and the electricity price arbitrage are considered in the models. Further, under the coordinated PEB charging scenario, a heuristics‐based method is developed to get the approximately optimal strategy with computation efficiency dramatically enhanced. Finally, the authors validate the effectiveness of the proposed strategies, interpret the effect of ESS prices on the usage of ESS and provide the sensitivity analysis of ESS capacity through the case studies.
Novel approaches to low‐cost MRI (1993)

This paper presents a combination of speculative approaches, some related to earlier work and some apparently novel, which show great promise in providing a new class of MRI machines that would be considerably less expensive. This class would have advantages and disadvantages as compared to existing MRI, over and above that of low cost. The disadvantages include the apparent inability to perform classic spectroscopy, and limited flexibility in the area of selective excitation. The advantages include a fundamental immunity to inhomogeneity and susceptibility problems, the ability to create a wide class of machines that are designed for specific anatomy-related applications, the ability to design open machines for physician access, and improved capability for high speed imaging. Generic to all of the methods presented are a pulsed polarizing field and an oscillatory read-out bias field. The pulsed field initially polarizes the magnetic moments. Since it is not on during the readout operation it has negligible homogeneity requirements since changes in the field amplitude will merely shade the image intensity. During readout a relatively low bias field is used. To enable the use of a relatively inhomogeneous bias field, an oscillatory field is used that has a zero average value. This prevents any long-term buildup of phase errors due to a frequency error associated with inhomogeneity. Thus the average bias frequency will be determined solely by the frequency rather than the amplitude of the bias field. Three methods are described, all including the above features. The first two involve imaging in the laboratory frame, while the third involves imaging in the rotating frame. The second approach requires no RF excitation and the third approach uses RF bias and gradient signals. Some approaches to slice selection are described.
DC Power Flow Revisited (2009)

Linear MW-only ldquodcrdquo network power flow models are in widespread and even increasing use, particularly in congestion-constrained market applications. Many versions of these approximate models are possible. When their MW flows are reasonably correct (and this is by no means assured), they can often offer compelling advantages. Given their considerable importance in today's electric power industry, dc models merit closer scrutiny. This paper attempts such a re-examination.
Live 3D Guidance in the Interventional Radiology Suite (2007)

This new combination further increases interventional radiologic capabilities because it provides real-time procedural evaluation and tracking.
Dominant Negative Guard Cell K+ Channel Mutants Reduce Inward-Rectifying K+ Currents and Light-Induced Stomatal Opening in Arabidopsis (2001)

Inward-rectifying potassium (K+(in)) channels in guard cells have been suggested to provide a pathway for K+ uptake into guard cells during stomatal opening. To test the proposed role of guard cell K+(in) channels in light-induced stomatal opening, transgenic Arabidopsis plants were generated that expressed dominant negative point mutations in the K+(in) channel subunit KAT1. Patch-clamp analyses with transgenic guard cells from independent lines showed that K+(in) current magnitudes were reduced by approximately 75% compared with vector-transformed controls at -180 mV, which resulted in reduction in light-induced stomatal opening by 38% to 45% compared with vector-transformed controls. Analyses of intracellular K+ content using both sodium hexanitrocobaltate (III) and elemental x-ray microanalyses showed that light-induced K+ uptake was also significantly reduced in guard cells of K+(in) channel depressor lines. These findings support the model that K+(in) channels contribute to K+ uptake during light-induced stomatal opening. Furthermore, transpirational water loss from leaves was reduced in the K+(in) channel depressor lines. Comparisons of guard cell K+(in) current magnitudes among four different transgenic lines with different K+(in) current magnitudes show the range of activities of K+(in) channels required for guard cell K+ uptake during light-induced stomatal opening.
Competitive algorithms for distributed data management (extended abstract) (1992)

We deal with the competitive analysis of algorithms for managing data in a distributed environment. We deal with the file allocation problem ([C], [DF], [ML]), where copies of a file may be stored in the local storage of some subset of processors, copies may be replicated and discarded over time so as to optimize communication costs, but multiple copies must be kept consistent and at least one copy must be stored somewhere in the network at all times. We deal with competitive algorithms for minimizing communication costs, over arbitrary sequences of reads and writes, and arbitrary network topologies. We define the constrained file allocation problem to be the solution of many individual file allocation problems simultaneously, subject to the constraints of local memory size. We give competitive algorithms for this prblem on uniform networks. We then introduce distributed competitive algorithms for on-line data tracking (a generalization of mobile user tracking [AP1, AP3] to transform our competitive distributed data management algorithms into distributed algorithms themselves.
Creating a transatlantic research enterprise for preventing Alzheimer's disease (2009)

In recognition of the global problem posed by Alzheimer's disease and other dementias, an international think-tank meeting was convened by Biocat, the Pasqual Maragall Foundation, and the Lou Ruvo Brain Institute in February 2009. The meeting initiated the planning of a European Union-North American collaborative research enterprise to expedite the delay and ultimate prevention of dementing disorders. The key aim is to build parallel and complementary research infrastructure that will support international standardization and inter-operability among researchers in both continents. The meeting identified major challenges, opportunities for research resources and support, integration with ongoing efforts, and identification of key domains to influence the design and administration of the enterprise.
Human neural stem cells: a new tool for studying cortical development in Down's syndrome (2003)

The clinical characteristics of Down's syndrome (DS), or trisomy 21, are caused by errors that occur during development. In addition to mental retardation, DS individuals have craniofacial abnormalities, clinical defects of the heart, gut and immune system, as well as predisposition to certain diseases, such as leukemias and Alzheimer's disease. To explain the developmental mechanisms that cause these traits, it is necessary to look at how developmental processes in DS compare to normal development. The neurological characteristics of DS are established during the prenatal and early postnatal period in humans, when the bulk of brain development occurs. Mouse models of DS have provided a useful way of studying DS neural development. However, there are clearly significant differences between rodent and human biology that may not be reflected in mouse models. Recent advances in stem cell biology now allow the generation of human neural tissue in the culture dish (Ostenfeld & Svendsen 2003). Stem cells offer a novel model system to study alterations in neuron development in developmental disorders such as DS.
Polyaniline / single-walled carbon nanotube composite electronic device (2004)

In this paper the composites of chemically synthesized polyaniline (PANI) and single walled carbon nanotubes (SWNTs) are investigated for electronic device applications by fabricating metal/semiconductor contacts. Current-voltage (I-V) characteristics of these composite materials are studied for different compositions and also at different temperatures. It is observed that with the increase in SWNT concentration the current level in the sample increases.
A Single Intramuscular Injection with an Adenovirus- Expressing IL-12 Protects BALB/c Mice Against Leishmania major Infection, While Treatment with an IL-4-Expressing Vector Increases Disease Susceptibility in B10.D2 Mice (1999)

Experimental infection of the susceptible BALB/c (H-2d) mouse with the intracellular parasite Leishmania major induces a predominant Th2-type T cell response that eventually leads to death. In contrast, the resistant B10.D2 (H-2d) strain develops Th1 cells that control parasite replication and disease. In this study, we tested the ability of a recombinant adenovirus vector-expressing IL-12 to skew the immune response in a Th1 direction and prevent leishmaniasis in susceptible mice. We report that BALB/c mice treated with the Ad5IL-12 vector on the same day as parasitic challenge are significantly protected against leishmaniasis and acquired long-lasting immunity, because upon rechallenge with L. major parasites they were resistant to disease. The vector-derived IL-12 expression was transient and highly localized to the tissue after i.m. injection; it caused an increase in the number of Ag-specific IFN-gamma-secreting lymphocytes and enhanced NK cell activity in the draining popliteal node. In contrast, resistant B10.D2 mice given i.m. injections with a recombinant adenovirus-expressing IL-4 displayed greater susceptibility to disease, and severe lesions were produced in some of the infected animals. These results suggest the potential use of recombinant adenoviruses expressing cytokines as potent immunomodulatory agents for the generation of protective immune responses against intracellular pathogens.