Submucosal Injection of Polyvinyl Alcohol Foam in Rabbit Bladder (1990)

No AccessJournal of UrologyReflux and Urinary Tract Infection1 Aug 1990Submucosal Injection of Polyvinyl Alcohol Foam in Rabbit Bladder P.A. Merguerian, G.A. McLorie, A.E. Khoury, P. Thorner, and B.M. Churchill P.A. MerguerianP.A. Merguerian , G.A. McLorieG.A. McLorie , A.E. KhouryA.E. Khoury , P. ThornerP. Thorner , and B.M. ChurchillB.M. Churchill View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39514-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Submucosal injection of either polytetrafluoroethylene (Teflon) or collagen has been used in the treatment of vesicoureteral reflux. Although the methods and principles of this treatment are effective, there are concerns regarding the safety and long-term effectiveness of these substances. We present a pilot study to explore the potential of an alternate substance (polyvinyl alcohol foam) for this treatment. Polyvinyl alcohol foam (Ivalon) particles measuring 150 to 250 μ. were injected submucosally into the bladder of New Zealand white rabbits. The bladder was examined macroscopically and microscopically at 1 and 2 weeks, and 1, 2 and 3 months after the injection. The particles created a raised lesion under the mucosa that was visible to the naked eye as late as 3 months after the submucosal injection. The particles remained in a submucosal location after 3 months. At 1 week after injection there was a foreign body giant cell response to the particles. At 3 months the giant cell response persisted and the particles were surrounded by a fibrotic reaction. There was little inflammatory response otherwise. These preliminary results indicate that polyvinyl alcohol foam may be suitable for subureteral injection in the treatment of vesicoureteral reflux. © 1990 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByHERZ D, HAFEZ A, BAGLI D, CAPOLICCHIO G, McLORIE G and KHOURY A (2018) EFFICACY OF ENDOSCOPIC SUBURETERAL POLYDIMETHYLSILOXANE INJECTION FOR TREATMENT OF VESICOURETERAL REFLUX IN CHILDREN: A NORTH AMERICAN CLINICAL REPORTJournal of Urology, VOL. 166, NO. 5, (1880-1886), Online publication date: 1-Nov-2001.FURNESS P, KOLLIGIAN M, LANG S, KAPLAN W, KROPP B and CHENG E (2018) INJECTABLE SMALL INTESTINAL SUBMUCOSA: PRELIMINARY EVALUATION FOR USE IN ENDOSCOPIC UROLOGICAL SURGERY.Journal of Urology, VOL. 164, NO. 5, (1680-1685), Online publication date: 1-Nov-2000.Smith D, Kaplan W and Oyasu R (2018) Evaluation of Polydimethylsiloxane as an Alternative in the Endoscopic Treatment of Vesicoureteral RefluxJournal of Urology, VOL. 152, NO. 4, (1221-1224), Online publication date: 1-Oct-1994.Atala A, Cima L, Kim W, Paige K, Vacanti J, Retik A and Vacanti C (2018) Injectable Alginate Seeded with Chondrocytes as a Potential Treatment for Vesicoureteral RefluxJournal of Urology, VOL. 150, NO. 2 Part 2, (745-747), Online publication date: 1-Aug-1993.Walker R, Wilson J and Clark A (2018) Injectable Bioglass as a Potential Substitute for Injectable PolytetrafluoroethyleneJournal of Urology, VOL. 148, NO. 2 Part 2, (645-647), Online publication date: 1-Aug-1992.Atala A, Peters C, Retik A and Mandell J (2018) Endoscopic Treatment of Vesicoureteral Reflux with a Self-Detachable Balloon SystemJournal of Urology, VOL. 148, NO. 2 Part 2, (724-727), Online publication date: 1-Aug-1992. Volume 144Issue 2 Part 2August 1990Page: 531-533 Advertisement Copyright & Permissions© 1990 by The American Urological Association Education and Research, Inc.MetricsAuthor Information P.A. Merguerian More articles by this author G.A. McLorie More articles by this author A.E. Khoury More articles by this author P. Thorner More articles by this author B.M. Churchill More articles by this author Expand All Advertisement Loading ...