gebhart/patrepeval huggingface dataset:
The glucose enzyme electrode: is simple peroxide detection at a needle sensor acceptable? (1988)

Needle type devices have been fabricated based on Pt anodes (to detect H2O2) mounted with stainless steel needles to act as the reference. Coating of these devices with glucose oxidase allowed glucose measurement, but with high dependence on stirring and background pO2 levels as well as a restricted glucose assay range. By wet dipcoating of microporous polyurethane or the application of preformed porous membranes, the linear range has been extended up to 70 mM glucose, to give minimal pO2 dependence and insensitivity to stirring. With incorporation of polyethersulphone membranes, blood measurement was possible with high selectivity (y = 0.954x + 0.202, r = 0.991, n = 48). This establishes that simple peroxide detection at a needle sensor is acceptable, and can now be focussed on increasing biocompatibility.
Electrohydrodynamic Generation and Delivery of Monodisperse Picoliter Droplets Using a Poly(dimethylsiloxane) Microchip (2006)

We developed a drop-on-demand microdroplet generator for the discrete dispensing of biosamples into a bioanalytical unit. This disposable PDMS microfluidic device can generate monodisperse droplets of picoliter volume directly out of a plane sidewall of the microfluidic chip by an electrohydrodynamic mechanism. The droplet generation was accomplished without using either an inserted capillary or a monolithically built-in tip. The minimum droplet volume was approximately 4 pL, and the droplet generation was repeatable and stable for at least 30 min, with a typical variation of less than 2.0% of drop size. The Taylor cone, which is usually observed in electrospray, was suppressed by controlling the surface wetting property of the PDMS device as well as the surface tension of the sample liquids. A modification of the channel geometry right before the opening of the microchannel also enhanced the continuous droplet generation without applying any external pumping. A simple numerical simulation of the droplet generation verified the importance of controlling the surface wetting conditions for the droplet formation. Our microdroplet generator can be effectively applied to a direct interface of a microfluidic chip to a biosensing unit, such as AMS, MALDI-MS or protein microarray-type biochips.
Chronic rhinosinusitis: Epidemiology and cost (2013)

Chronic rhinosinusitis (CRS) is one of the most common chronic diseases and is associated with a high socioeconomic burden from direct and indirect costs. Its estimated prevalence ranges widely, from 2 to 16%. It is more common in female subjects, aged 18-64 years, and in southern and midwestern regions of the United States. CRS is more prevalent in patients with comorbid diseases such as asthma, chronic obstructive pulmonary disease, and environmental allergies. Few studies examine patient ethnicity, socioeconomic status, geographic location, and cultural factors in CRS populations. This article provides an overview of the epidemiology, racial variations, and economic burden of CRS.
Ion implantation enhanced intermixing of Al-free 980 nm laser structures (1998)

An investigation of the intermixing enhancement in an InGaAs/InGaAsP/InGaP partial laser structure following phosphorous implantation at 30, 80, and 7000 keV was carried out. We find that for the 30 and 80 keV implant energies, band gap shifts in excess of 80 meV could be imparted to a single embedded 8.5 nm InGaAs quantum well (QW) lying several thousand angstroms beyond the maximum ion range. As both the 30 and 80 keV implants kept the end of range damage spatially separate from optical mode region, the optical quality (inferred from photoluminescence intensity measurements) of the QW material was preserved to a greater extent than that resulting from the 7000 keV implants (where implant damage was directly created in the QW during ion bombardment). This result suggests that device structures containing InGaP cladding layers are well suited for monolithic integration as the masking of low energy ions with high lateral resolution can be achieved using routinely available masking techniques.
Local Consistency Constrained Adaptive Neighbor Embedding for Text Image Super-Resolution (2012)

This paper proposes a robust single-image super-resolution method for enlarging low quality camera captured text image. The contribution of this work is twofold. First, we point out the non-local reconstruction problem in neighbor embedding based super-resolution by statistical analysis on an empirical data set. Second, we introduce a local consistency constraint to explicitly regularize the linear reconstruction process, and adaptively generate the most possible candidates for the high-resolution image patch. For the non-consistent candidates, we rely on its adjacent overlapping patches for capability verification. Experimental results demonstrate that our solution produces visually pleasing enlargements for various text images.
Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat (2000)

Myotonic dystrophy (DM), the most common form of muscular dystrophy in adult humans, results from expansion of a CTG repeat in the 3' untranslated region of the DMPK gene. The mutant DMPK messenger RNA (mRNA) contains an expanded CUG repeat and is retained in the nucleus. We have expressed an untranslated CUG repeat in an unrelated mRNA in transgenic mice. Mice that expressed expanded CUG repeats developed myotonia and myopathy, whereas mice expressing a nonexpanded repeat did not. Thus, transcripts with expanded CUG repeats are sufficient to generate a DM phenotype. This result supports a role for RNA gain of function in disease pathogenesis.
Social capital on facebook (2011)

Though social network site use is often treated as a monolithic activity, in which all time is equally social and its impact the same for all users, we examine how Facebook affects social capital depending upon: (1) types of site activities, contrasting one-on-one communication, broadcasts to wider audiences, and passive consumption of social news, and (2) individual differences among users, including social communication skill and self-esteem. Longitudinal surveys matched to server logs from 415 Facebook users reveal that receiving messages from friends is associated with increases in bridging social capital, but that other uses are not. However, using the site to passively consume news assists those with lower social fluency draw value from their connections. The results inform site designers seeking to increase social connectedness and the value of those connections.
Direct plant regeneration from leaf explants in cucumber (Cucumis sativus L.) is free of stable genetic variation (1995)

Abstract A new procedure is described for rapid and efficient plant regeneration from leaf explants of Cucumis sativus and C. anguria. The following factors were most important: young leaves, the NO 3 : NH 4 ratio in the plant induction medium, small explants and the growth regulator combination. After about 4 weeks of culture under optimal growth conditions, the frequency of regeneration was 10–100% of explants. Six to 7 weeks were required to obtain well‐rooted plants, which were mostly able to survive after transfer into soil. From a single young leaf of C. sativus cv. ‘Borszezagowski’, 135 plants could be regenerated. All plants transferred to a greenhouse were free of morphological or physiological abnormalities, flowered normally and bore fruits. The analysis of R 0 plants showed no genetic variation, whereas in the R 1 two new phenotypes, which were not transmittable to the R 2 , were observed. This procedure is recommended for its production of homogeneous cucumber plants.
Bandgap and Molecular Energy Level Control of Conjugated Polymer Photovoltaic Materials Based on Benzo[1,2-b:4,5-b′]dithiophene (2008)

Bandgap and molecular energy level control are of great importance in improving photovoltaic properties of conjugated polymers. A common approach to tuning these parameters is to modify the structure of conjugated polymers by copolymerizing with different units. In this paper, research work focuses on the synthesis of benzo[1,2-b:4,5-b′]dithiophene (BDT) with different conjugated units and their photovoltaic performance. Eight new BDT-based polymers with commonly used conjugated units, including thiophene, benzo[c][1,2,5]thiadiazole (BT), thieno[3,4-b]pyrazine (TPZ), etc., were synthesized. The bandgaps of the polymers were tuned in the range of 1.0−2.0 eV, and their HOMO and LUMO energy levels could also be tuned effectively. The absorption spectra as well as electrochemical and photovoltaic properties of these polymers were investigated systematically. Some units exhibiting the same effect of bandgap lowering exhibited different effects on molecular energy levels of the polymers. For example, the TPZ unit can reduce the bandgap by lowering the LUMO energy level and elevating the HOMO level of the polymer, but the BT unit can lower the bandgap only by depressing the LUMO level. Since open-circuit voltage (Voc) of the heterojunction polymer solar cell is believed to be inversely proportional to the HOMO level of electron donor material, Voc of the devices based on H9, the copolymer of BDT and TPZ, was ca. 0.5 V lower than that of the device based on H7, the copolymer of BDT and BT. The effects of seven commonly used units on bandgap, molecular energy level, and photovoltaic properties of the BDT based polymers are studied and discussed in this paper, which can provide a guideline not only for design of photovoltaic materials but also for materials of various other electronic devices. In addition, the PCE of the device based on PCBM and H6, one of the BDT-based polymers, reached 1.6%, and Voc, Isc, and FF of the device were 0.75 V, 3.8 mA/cm2, and 56%, respectively, which indicates that BDT is a promising common unit for photovoltaic conjugated polymers. Since we have developed the synthetic method of the 4,8-bisalkoxy-BDT monomer, the BDT unit will play an important role in future research on conjugated polymer design.
VIMACS—A Vertical Interval Machine Control System (1982)

The American Television Industry is a unique blend of show business and advertising tied together with Engineering and Technology. As such the broadcaster is constantly striving to improve his “On Air Look”, reduce presentation errors and consequent loss of income. Modern day Telecasting has come to rely upon pre-recorded material for much of its broadcast day. The key to a smooth “On Air Look” is accurately timed Machine starts. This is achieved either by local operation at the source, or preferably, by Remote Control at the point of use. Depending upon the size of the operation, there can be many such control points. The system which allows this control is one of the hearts of a modern T.V. Broadcasting plant.
Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS (1984)

Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.
Quantum information processing by weaving quantum Talbot carpets (2015)

Single-photon interference due to passage through a periodic grating is considered in a novel proposal for processing $D$-dimensional quantum systems (quDits) encoded in the spatial degrees of freedom of light. We show that free-space propagation naturally implements basic single-quDit gates by means of the Talbot effect: an intricate time-space carpet of light in the near-field diffraction regime. By adding a diagonal phase gate, we show that a complete set of single-quDit gates can be implemented. We then introduce a spatially dependent beam splitter that allows for projective measurements in the computational basis and can be used for the implementation of controlled operations between two quDits. Universal quantum information processing can then be implemented with linear optics and ancilla photons via postselection and feed-forward following the original proposal of Knill-Laflamme and Milburn. Although we consider photons, our scheme should be directly applicable to a number of other physical systems. Interpretation of the Talbot effect as a quantum logic operation provides a beautiful and interesting way to visualize quantum computation through wave propagation and interference.
Analysis of the OspE Determinants Involved in Binding of Factor H and OspE-Targeting Antibodies Elicited during Borrelia burgdorferi Infection in Mice (2003)

Immune evasion by Lyme spirochetes is a multifactorial process involving numerous mechanisms. The OspE protein family undergoes antigenic variation during infection and binds factor H (fH) and possibly FHL-1/reconectin. In Borrelia burgdorferi B31MI, the OspE family consists of three paralogs: BBL39 (ErpA), BBP38, and BBN38 (ErpP). BBL39 and BBP38 are identical and therefore are referred to here as BBL39. The goals of this study were to assess the specificity of the antibody (Ab) response to the OspE paralogs and to identify the domains or determinants of OspE that are required for the binding of fH and OspE-targeting Abs that develop during infection. Here we demonstrate that at least some of the anti-OspE Abs produced during infection are paralog specific and that Ab binding requires conformational determinants whose formation requires both the N- and C-terminal domains of OspE. The binding of fH to OspE was also found to be dependent on conformational determinants. It is also demonstrated here that all of the OspE paralogs expressed by B. burgdorferi B31MI are capable of binding fH. The binding of fH to members of the OspF protein family was also assessed. In contrast to an earlier report, no binding of BBO39 or BBR42 to human fH was detected. Lastly, a series of competitive binding enzyme-linked immunosorbent assay analyses, designed to determine if fH and infection serum Abs bind to the same sites on OspE, revealed that these ligands interact with different regions of OspE.
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. (1987)

Expression of the cardiac myosin isozymes is regulated during development, by hormonal stimuli and hemodynamic load. In this study, the levels of expression of the two isoforms (alpha and beta) of myosin heavy chain (MHC) during cardiac hypertrophy were investigated at the messenger RNA (mRNA) and protein levels. In normal control and sham-operated rats, the alpha-MHC mRNA predominated in the ventricular myocardium. In response to aortic coarctation, there was a rapid induction of the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular weight. Administration of thyroxine to coarctated animals caused a rapid deinduction of beta-MHC and induction of alpha-MHC, both at the mRNA and protein levels, despite progression of left ventricular hypertrophy. These results suggest that the MHC isozyme transition during hemodynamic overload is mainly regulated by pretranslational mechanisms, and that a complex interplay exists between hemodynamic and hormonal stimuli in MHC gene expression.
Aerosol fabrication of hollow mesoporous silica nanoparticles and encapsulation of l-methionine as a candidate drug cargo (2010)

Hollow spherical nanoparticles with ordered mesoporous silica shells were fabricated by evaporation-induced self-assembly using (NH(4))(2)SO(4) and cetyltrimethyl ammonium bromide (CTAB) as templates. The model drug, L-methionine, was encapsulated within the spherical void at high loadings by repeated crystallization.
Pyrido[2,3-d]pyrimidines. III. Synthesis of some 8-.beta.-D-ribofuranosylprido[2,3-d]pyrimidines structurally related to the antibiotic sangivamycin (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrido[2,3-d]pyrimidines. III. Synthesis of some 8-.beta.-D-ribofuranosylprido[2,3-d]pyrimidines structurally related to the antibiotic sangivamycinBoshra H. Rizkalla and Arthur D. BroomCite this: J. Org. Chem. 1972, 37, 25, 3980–3985Publication Date (Print):December 1, 1972Publication History Published online1 May 2002Published inissue 1 December 1972https://pubs.acs.org/doi/10.1021/jo00798a002https://doi.org/10.1021/jo00798a002research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Conducting Polymer Composites (1992)

Electrically conducting latexes of polypyrrole coated on inorganic cores were obtained by deposition of pyrrole on catalytically active particles. The finely dispersed core materials were hematite (polyhedral and spindle-type), silica coated with hematite, magnetite, and cerium(IV) oxide. The degree of polymer coverage could be controlled by varying the aging time and the properties of the carrier particles. Also, yttrium basic carbonate was coated on polypyrrole latex. The so prepared coated powders were examined by transmission electron microscopy, and further characterized by elemental and thermogravimetric analyses, as well as by electrophoresis, X-ray diffraction, and conductivity measurements. The d.c. conductivities of all but the magnetite particles coated with polymer were comparable to those reported for pure polypyrrole and they increased with pressure.
Optical routing of asynchronous, variable length packets (2000)

We discuss the introduction/implementation of optical IP routers, then we introduce a novel scheduling algorithm incorporating void filling and aimed at optical routing of asynchronous, variable packet length packets. We describe its structure and discuss the complexity issues. Albeit introduced with the purpose of cancelling expensive optical synchronization, we argue that this approach represents the most viable all-optical approach for implementing packets-over-SONET (IP-centric scenario). We also present simulations under self-similar traffic conditions which point to the inefficiency of optical buffering to combat the effects of self-similarity, and we outline alternative strategies for proper buffer dimensioning.
Lasers in percutaneous disc surgery: Beneficial technology or gimmick? (1993)

(1993). Lasers in percutaneous disc surgery: Beneficial technology or gimmick? Acta Orthopaedica Scandinavica: Vol. 64, No. sup251, pp. 38-44.
HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse? (2010)

Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. Here, we discuss recent data supporting this hypothesis, which further explains how DCs can capture and internalize retroviruses like HIV-1 in the absence of fusion events, leading to the productive infection of interacting CD4(+) T cells and contributing to viral spread through a mechanism known as trans-infection. We suggest that HIV-1 can exploit an exosome antigen-dissemination pathway intrinsic to mDCs, allowing viral internalization and final trans-infection of CD4(+) T cells. In contrast to previous reports that focus on the ability of immature DCs to capture HIV in the mucosa, this review emphasizes the outstanding role that mature DCs could have promoting trans-infection in the lymph node, underscoring a new potential viral dissemination pathway.
A Small ATPase Protein of Arabidopsis, TGD3, Involved in Chloroplast Lipid Import (2007)

Polar lipid trafficking is essential in eukaryotic cells as membranes of lipid assembly are often distinct from final destination membranes. A striking example is the biogenesis of the photosynthetic membranes (thylakoids) in plastids of plants. Lipid biosynthetic enzymes at the endoplasmic reticulum and the inner and outer plastid envelope membranes are involved. This compartmentalization requires extensive lipid trafficking. Mutants of Arabidopsis are available that are disrupted in the incorporation of endoplasmic reticulum-derived lipid precursors into thylakoid lipids. Two proteins affected in two of these mutants, trigalactosyldiacylglycerol 1 (TGD1) and TGD2, encode the permease and substrate binding component, respectively, of a proposed lipid translocator at the inner chloroplast envelope membrane. Here we describe a third protein of Arabidopsis, TGD3, a small ATPase proposed to be part of this translocator. As in the tgd1 and tgd2 mutants, triacylglycerols and trigalactolipids accumulate in a tgd3 mutant carrying a T-DNA insertion just 5' of the TGD3 coding region. The TGD3 protein shows basal ATPase activity and is localized inside the chloroplast beyond the inner chloroplast envelope membrane. Proteins orthologous to TGD1, -2, and -3 are predicted to be present in Gram- bacteria, and the respective genes are organized in operons suggesting a common biochemical role for the gene products. Based on the current analysis, it is hypothesized that TGD3 is the missing ATPase component of a lipid transporter involving TGD1 and TGD2 required for the biosynthesis of ER-derived thylakoid lipids in Arabidopsis.
[Expression of S100A8 and A100A9 in giant cell tumor of bone and its relation with CT and MR imaging findings]. (2015)

The expression of S100A8 and S100A9 mRNA and protein is up-regulated in GCT of bone. The expression of S100A8 and S100A9 is associated with the real composition ratio and the degree of bone destruction, respectively, indicating that S100A8 and S100A9 may be involved in the biological behavior of bone GCT.