gebhart/patrepeval huggingface dataset:
Mechanism of the progression of diabetic nephropathy to renal failure. (1997)

Although the evolution of diabetic nephropathy is brought about mostly by persistent hyperglycemia, its progression may be influenced by various other factors such as hypertension and dietary protein intake. It has been recently suggested in the literature that the gene polymorphism of angiotensin converting enzyme (ACE) might be associated with the development of diabetic nephropathy, because the DD genotype of ACE gene is closely associated with the presence of nephropathy in diabetic subjects. However, in our present analysis the frequency of the DD genotype in patients with non-insulin dependent diabetes is not significantly related to the presence or absence of nephropathy. It remains to be clarified by multi-center analysis using large numbers of patients whether the gene polymorphism of ACE is related to the progression of diabetic nephropathy to renal failure. Furthermore, it has been postulated that the interstitial fibrosis evaluated in renal biopsy specimens is significantly correlated with the declining of renal function in diabetic patients. However, it is not possible to clinically quantitate the interstitial fibrosis without performing renal biopsy. We have recently found that the urinary excretion of type IV collagen is significantly increased in diabetic patients. Moreover, the increase in urinary type IV collagen is well correlated with the amount of urinary albumin. Since type IV collagen in the urine is probably derived from tubulointerstitial tissue, it is likely that the increased amount of type IV collagen in the urine may reflect the fibrotic change in diabetic kidneys. Whether the increase in urinary type IV collagen is able to predict for the progression of diabetic nephropathy in the future should be examined.
Chemical Odorant of Colonial Seabird Repels Mosquitoes (2005)

The crested auklet, Aethia cristatella, emits a class of aldehydes shown to be potent invertebrate repellents when used by heteropterans against their predators. Our aim was to determine the efficacy of these aldehydes against mosquitoes in the laboratory. Synthetic analogues of the auklet odorant were strongly repellent to mosquitoes in controlled laboratory trials. Furthermore, the efficacy was similar to previous reports for commercial mosquito repellents. These results, in combination with a previously published study, show that constituents of the aldehyde odorant are broad spectrum in efficacy against ectoparasitic arthropods of birds. Our report is the first empirical evidence for an endogenous mosquito repellent in birds.
An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis. (1997)

Recent analysis of bladder tumors has correlated expression of the neurokine midkine (MK) with poor patient survival. To examine a role for MK and the related pleiotrophin (PTN) in tumorigenesis, they were overexpressed in MCF-7 breast carcinoma cells. Expression had no effect on in vitro growth but conferred a growth advantage in vivo. Enhanced tumor growth correlated with increased vascular density and endothelial proliferation, implicating an angiogenic role for MK and PTN. Angiogenic activity of MK and PTN was confirmed in the rabbit corneal assay. Our data therefore identify two novel targets for antiangiogenic drug development.
Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus (1990)

Blood mononuclear cells from 47 cats experimentally infected with feline immunodeficiency virus (FIV) were examined by using monoclonal antibodies directed against feline CD4 and CD8 homologs, a pan-T-cell antigen, and cell surface immunoglobulin. Significant inversion of the CD4+/CD8+ T-cell ratio was observed only in cats that were infected for 18 months or more. This inversion was associated with a decrease in the absolute numbers of CD4+ T cells and a concomitant increase in CD8+ cells. However, the total numbers of circulating T and B cells were not significantly reduced. Cats infected with FIV for 24 to 28 months also had significantly elevated levels of serum immunoglobulin G (IgG), but normal levels of IgA and IgM. The long-term decline in CD4+ T cells and hypergammaglobulinemia observed in FIV-infected cats resemble the abnormalities occurring in humans after human immunodeficiency virus infection.
Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation (2010)

Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G(1)-G(0) phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target of rapamycin (mTOR), a central regulator of cell proliferation. This is evidenced by the findings that CPT inhibited type I insulin-like growth factor I- or 10% fetal bovine serum-stimulated phosphorylation of mTOR, p70 S6 kinase 1, and eukaryotic initiation factor 4E binding protein 1 in a concentration- and time-dependent manner. Expression of constitutively active mTOR conferred resistance to CPT inhibition of cyclin D1 expression and Rb phosphorylation, as well as cell growth. The results suggest that CPT is a novel antiproliferative agent.
Methicillin-resistant staphylococci (1961)

Eighteen strains of Staph. pyogenes (nine penicillin-sensitive and nine penicillin-destroying) were passaged 40 to 50 times on Celbenin(1) ditch plates. All strains developed an increase in resistance to Celbenin and eight strains (four penicillin-sensitive and four penicillin-destroying) were able to grow in 100 mug/ml. or more Celbenin. Resistance was of the drug-tolerant type and none of the cultures inactivated Celbenin. There was an associated increase in tolerance to benzyl penicillin. The highly Celbenin-resistant cultures isolated from penicillin-destroying staphylococci were in sharp contrast to those from penicillin-sensitive strains, as well as to penicillin G-tolerant staphylococci isolated in vitro, because they retained the cultural characteristics, coagulase and haemolytic activity, and mouse virulence of the parent strains, and the degree of resistance remained stable after repeated passage in the absence of Celbenin. Three naturally occurring Celbenin-resistant strains of Staph. pyogenes isolated from infective processes were also studied. All three strains grew luxuriantly in concentrations of Celbenin up to 12.5 mug/ml. but very poorly in higher concentrations. The possible significance of these findings is discussed.
Synthesis of two metabolites of (-)-.DELTA.8-tetrahydrocannabinol (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of two metabolites of (-)-.DELTA.8-tetrahydrocannabinolKenneth E. FahrenholtzCite this: J. Org. Chem. 1972, 37, 13, 2204–2207Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://pubs.acs.org/doi/10.1021/jo00978a032https://doi.org/10.1021/jo00978a032research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HMB-45/Melan-A and Smooth Muscle Actin-Positive Clear-Cell Epithelioid Tumor Arising in the Ligamentum Teres Hepatis (2000)

HMB-45-positive clear-cell epithelioid tumor arising in the ligamentum teres hepatis of a 13-year-old Japanese girl is described. The well-defined tumor was completely removed and measured 9 x 7 x 6 cm. Cut sections showed a tan-white, homogeneous appearances with no hemorrhage or necrosis. The tumor was composed of nests or sheets of polygonal or oval-shaped cells rich in clear or finely granular cytoplasm. Capillary network was well developed, and sinusoid vessels were often seen with occasional perivascular hyalinization. There was moderate nuclear atypia but mitotic figures were absent. Periodic acid-Schiff stain showed a large amount of glycogen digested by diastase. Immunohistochemical stains for smooth muscle actin, Melan-A, and HMB-45 were positive in most of the tumor cells. Stains for vimentin, muscle actin, and HAM56 were focally positive, whereas stains for desmin, cytokeratin, epithelial membrane antigen, S-100, CD34, CD68, CD99, neurofilament proteins, and estrogen/progesterone receptors were negative. Ultrastructurally, the cytoplasm contained a considerable number of mitochondria, monoparticipate or membrane-bound glycogen, and longitudinally oriented thin filaments with focal condensations and subplasmalemmal densities. The histopathology of the present case, originally interpreted as epithelioid leiomyoma, was consistent with clear cell "sugar" tumors. The present case may indicate ubiquitous distribution of clear cell "sugar tumors" of which histogenesis remains unknown but is presumed to be of perivascular epithelioid cell origin.
Power scaling of diffraction limited fiber sources (2005)

Single-mode (SM) fiber lasers and amplifiers are constrained to low output powers by fundamental physical limitations of the fiber, specifically, by low energy storage and by the onset of nonlinear processes in the fiber. The simplest way to overcome both limiting factors is to increase the core size, but maintaining SM operation imposes an upper limit. Further power scaling is possible with multimode (MM) fiber, but the poor beam quality generally associated MM fiber is unacceptable for most applications. We have developed a technique (bend-loss-induced mode filtering) that allows the core size to be increased significantly beyond the SM limit while maintaining diffraction-limited beam quality and high efficiency. In this method, coiling of the fiber is used as a form of distributed spatial filtering to suppress all but the fundamental mode of a highly MM fiber amplifier. Unlike conventional spatial filtering, in which high-order modes are discarded, the mode-filtering technique does not result is substantial loss of efficiency because high-order modes are suppressed along the entire length of the amplifier and are thus prevented from building up significant intensity. We will review this method and recent experimental results for both cw and pulsed fiber sources, including nonlinear frequency conversion of mode-filtered fiber lasers. Optical damage issues will also be discussed.
Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity (2007)

These results suggest that autoantigen mimicry cannot be reliably invoked as a general mechanism for HIV immune evasion.
Relationship between the tumor necrosis factor system and the serum interleukin-4, interleukin-5, interleukin-8, eosinophil cationic protein, and immunoglobulin E levels in the bronchial hyperreactivity of adults and their children. (2003)

The aim of the study was to investigate the activation of inflammatory mediators interleukin (IL)-4, IL-5, and IL-8; immunoglobulin E (IgE); and eosinophil cationic protein (ECP) and to evaluate the regulatory role of the tumor necrosis system (TNF) system in bronchial hyperreactivity. Adults who had suffered from bronchial asthma in childhood but who had been symptom free for at least 3 years were examined together with their children who did not have asthma. The serum concentrations of TNF-alpha, soluble TNF receptor 1 (sTNF-R1), TNF-R2, IL-4, IL-5, IL-8, ECP, and IgE were studied in symptom-free adults (n = 22) and their children (n = 22) with bronchial hyperreactivity. Nonhyperreactive individuals with a similar medical history (adults, n = 17; children, n = 20) served as controls. Significantly elevated serum TNF-alpha (X +/- SD: 5.13 +/- 1.37 pg/mL versus 3.91 +/- 0.61 pg/mL; p < 0.0001), sTNF-R1 (X +/- SD: 1.37 +/- 0.28 ng/mL versus 1.16 +/- 0.13 ng/mL; p = 0.0002), and sTNF-R2 (X +/- SD: 0.78 +/- 0.42 ng/mL versus 0.43 +/- 0.41 ng/mL; p = 0.0001); IL-4 (X +/- SD: 4.05 +/- 1.02 pg/mL versus 3.34 +/- 0.84 pg/mL; p = 0.0016); IgE (X +/- SD: 390.1 +/- 361.4 KU/L versus 130.2 +/- 166.1 KU/L; p = 0.0001); and ECP (X +/- SD: 17.57 +/- 11.03 micrograms/L versus 10.65 +/- 6.01 micrograms/L; p = 0.0016) concentrations were measured in the subjects with bronchial hyperreactivity as compared with the nonhyperreactive group. Significant positive linear correlations were observed for the bronchial hyperreactive group between the concentrations of TNF-alpha and ECP, TNF-alpha and sTNF-R1, TNF-alpha and IL-8, sTNF-R1 and ECP, sTNF-R1 and IL-8, and sTNF-R2 and IL-8. Moreover, the TNF-alpha and sTNF-R2 levels correlated with the airway reactivity in the hyperreactive group. We suggest that the elevated cytokine levels indicate activation of the immune system in individuals who were previously asthmatic, but recovered, and are now symptom free and in their children with nonasthmatic bronchial hyperreactivity. The TNF system may play a key role in the pathomechanism of bronchial hyperreactivity.
1,5-Diazabicyclo[4.3.0]non-5-ene (2006)

[3001-72-7] C7H12N2 (MW 124.19) InChI = 1S/C7H12N2/c1-3-7-8-4-2-6-9(7)5-1/h1-6H2 InChIKey = SGUVLZREKBPKCE-UHFFFAOYSA-N (organic soluble base for elimination reactions,2-11 isomerizations,12-19 esterifications,26-31 and condensations20-25) Alternate Names: DBN. Physical Data: bp 95–98 °C/7.5 mmHg; d 1.005 g mL−1. Solubility: sol polar solvents such as water, ethanol, benzene, methylene chloride, chloroform, THF, and DMSO. Form Supplied in: clear, colorless or light yellow liquid. Handling, Storage, and Precautions: stable at ambient temperatures, but is hygroscopic; contact with undiluted product may cause skin irritation or burns.
Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations. (1979)

A progression of univariate followed by multivariate analyses was applied to 46 variables selected from the clinical examination, exercise test, coronary arteriography, and quantitative angiographic assessment of left ventricular function in patients with coronary disease to determine those variables most predictive of survival. For the 733 medically treated patients, the final Cox's regression analysis showed that the left ventricular ejection fraction was most predictive of survival, followed by age, number of vessels with stenosis(es) greater than or equal to 70%, and ventricular arrhythmia on the resting electrocardiogram. For the 1870 surgically treated patients, ventricular arrhythmia on the resting electrocardiogram was most predictive of survival followed by ejection fraction, heart murmur, left main coronary artery stenosis greater than or equal to 50%, and use of diuretic agents.
αVβ3 Integrin Crystal Structures and Their Functional Implications (2012)

Many questions about the significance of structural features of integrin α(V)β(3) with respect to its mechanism of activation remain. We have determined and re-refined crystal structures of the α(V)β(3) ectodomain linked to C-terminal coiled coils (α(V)β(3)-AB) and four transmembrane (TM) residues in each subunit (α(V)β(3)-1TM), respectively. The α(V) and β(3) subunits with four and eight extracellular domains, respectively, are bent at knees between the integrin headpiece and lower legs, and the headpiece has the closed, low-affinity conformation. The structures differ in the occupancy of three metal-binding sites in the βI domain. Occupancy appears to be related to the pH of crystallization, rather than to the physiologic regulation of ligand binding at the central, metal ion-dependent adhesion site. No electron density was observed for TM residues and much of the α(V) linker. α(V)β(3)-AB and α(V)β(3)-1TM demonstrate flexibility in the linker between their extracellular and TM domains, rather than the previously proposed rigid linkage. A previously postulated interface between the α(V) and β(3) subunits at their knees was also not supported, because it lacks high-quality density, required rebuilding in α(V)β(3)-1TM, and differed markedly between α(V)β(3)-1TM and α(V)β(3)-AB. Together with the variation in domain-domain orientation within their bent ectodomains between α(V)β(3)-AB and α(V)β(3)-1TM, these findings are compatible with the requirement for large structural changes, such as extension at the knees and headpiece opening, in conveying activation signals between the extracellular ligand-binding site and the cytoplasm.
Human Tumor Xenograft Models in NCI Drug Development (1997)

The preclinical discovery and development of anticancer drugs by the NCI consist of a series of test procedures, data review, and decision steps that have been summarized recently (1). Test procedures are designed to provide comparative quantitative data, which in turn, permit selection of the best candidate agents from a given chemical or biological class. Periodic, comprehensive reviews by various NCI committees serve not only to identify and expedite the development of active lead compounds that may provide more efficacious treatments for human malignancy, but also to eliminate agents that are inactive and/or highly toxic from further consideration.KeywordsHollow FiberTest AgentAthymic MouseHuman Tumor XenograftHuman Tumor Xenograft ModelThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Conjugate gradient eigenstructure tracking for adaptive spectral estimation (1995)

A conjugate gradient iteration is derived that converges to the set of r dominant/subdominant eigenpairs. This iteration is used to construct two eigenstructure tracking algorithms that track the r-dimensional dominant or subdominant subspaces of time-varying data or data-covariance matrices. The two eigenstructure tracking algorithms have update complexities O(m/sup 2/r) and the other O(mr/sup 2/), where m is the data dimension. The algorithms are customized to solve high resolution temporal and spatial frequency tracking problems. They are compared with existing techniques by tying into published simulation based performance tests. The algorithms demonstrate rapid convergence and tracking characteristics at a competitive cost.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
p63 expression profiles in human normal and tumor tissues. (2002)

Our data support a role for p63 in squamous and transitional cell carcinomas, as well as certain lymphomas and thymomas.
Evaluation of health status of calves and the impact on feedlot performance: assessment of a retained ownership program for postweaning calves. (2002)

The objective of this study was to evaluate animal health status at entry to a feedlot against feedlot performance and carcass value. There were 24 herds represented by 417 calves in a retained ownership program. The health status at entry was represented by the levels of serum antibody to infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhea viruses 1 and 2 (BVDV1a, BVDV2), parainfluenza 3 virus (PI3V), bovine respiratory syncytial virus (BRSV), Mannheimia haemolytica, and Pasteurella multocida, as well as by the presence of virus in nasal swabs and blood leukocytes and the presence of bacteria in nasal swabs. The presence or absence of viruses or bacteria at entry did not predict subsequent illness. However, there were predictors of illness severity (number of treatments) and performance parameters of feedlot performance. Herds with a low morbidity rate had higher levels of BVDV1a antibodies than herds with a high morbidity rate. On both an individual-animal and a herd-average basis, calves with low levels of antibody to BVDV1a and BVDV2 had increased total treatment costs. Also, for individual animals and the herd as a whole, low levels of antibody to P. multocida, BVDV1a, and BVDV2 were related to decreased net value to owner (carcass value minus total feedlot cost). Calves treated twice or more had lower levels of antibody to BVDV1a than those treated once or not at all. Differences in herd morbidity rate and treatment costs were more related to appropriate timing of vaccine (last dose at or near delivery of calf) or lack of a 2nd dose of killed vaccine. This was best illustrated by the levels of antibody to BVDV1a. The results of this study were used to formulate recommendations for the subsequent year.
The promise of concentrators (2000)

This paper addresses the issue of why concentrator systems have not gained a significant market share. The history of concentrator development is reviewed, and the status of existing concentrator efforts outlined. A critical look at the requirements to propel concentrators to a prominent market role in large-scale power production is presented. Various concentrator and flat-plate PV system approaches are compared by computing the expected cost of energy, and conclusions are drawn as to what the best course of action will be. Concentrator systems are projected to be the lowest-cost, lowest-risk PV option for medium and large PV power plants. Copyright © 2000 John Wiley & Sons, Ltd.
Thymosin β 4 increases hair growth by activation of hair follicle stem cells (2003)

Thymosin beta4, a 43-amino acid polypeptide that is an important mediator of cell migration and differentiation, also promotes angiogenesis and wound healing. Here, we report that thymosin beta4 stimulates hair growth in normal rats and mice. A specific subset of hair follicular keratinocytes in mouse skin expresses thymosin beta4 in a highly coordinated manner during the hair growth cycle. These keratinocytes originate in the hair follicle bulge region, a niche for skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely related, if not identical, to the bulge-residing stem cells, were isolated and their migration and differentiation increased in the presence of nanomolar concentrations of thymosin beta4. Expression and secretion of the extracellular matrix-degrading enzyme matrix metalloproteinase-2 were increased by thymosin beta4. Thus, thymosin beta4 accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.