gebhart/patrepeval huggingface dataset:
Determining the sentiment of opinions (2004)

Identifying sentiments (the affective parts of opinions) is a challenging problem. We present a system that, given a topic, automatically finds the people who hold opinions about that topic and the sentiment of each opinion. The system contains a module for determining word sentiment and another for combining sentiments within a sentence. We experiment with various models of classifying and combining sentiment at word and sentence levels, with promising results.
α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer (2002)

AMACR was shown to be overexpressed in prostate cancer using independent experimental methods and prostate cancer specimens. AMACR may be useful in the interpretation of prostate needle biopsy specimens that are diagnostically challenging.
Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3 (2012)

Interactions between killer immunoglobulin-like receptors (KIRs) and their HLA-A, -B, and –C ligands diversify the functions of human natural killer cells. Consequently, combinations of KIR and HLA genotypes affect resistance to infection and autoimmunity, success of reproduction and outcome of hematopoietic cell transplantation. HLA-C, with its C1 and C2 epitopes, evolved in hominids to be specialized KIR ligands. The system’s foundation was the C1 epitope, with C2 a later addition, by several million years. The human inhibitory receptor for C1 is encoded by KIR2DL2/3, a gene having two divergent allelic lineages: KIR2DL2 a B KIR haplotype component and KIR2DL3 an A KIR haplotype component. Although KIR2DL2 and KIR2DL3 exhibit quantitative differences in specificity and avidity for HLA-C, they qualitatively differ in their genetics, functional effect and clinical influence. This is due to linkage disequilibrium between KIR2DL2 and KIR2DS2, a closely related activating receptor that was selected for lost recognition of HLA-C.
Highly efficient GaAs solar cells by limiting light emission angle (2013)

In a conventional flat plate solar cell under direct sunlight, light is received from the solar disk, but is re-emitted isotropically. This isotropic emission corresponds to a significant entropy increase in the solar cell, with a corresponding drop in efficiency. Here, using a detailed balance model, we show that limiting the emission angle of a high-quality GaAs solar cell is a feasible route to achieving power conversion efficiencies above 38% with a single junction. The highest efficiencies are predicted for a thin, light trapping cell with an ideal back reflector, though the scheme is robust to a non-ideal back reflector. Comparison with a conventional planar cell geometry illustrates that limiting emission angle in a light trapping geometry not only allows for much thinner cells, but also for significantly higher overall efficiencies with an excellent rear reflector. Finally, we present ray-tracing and detailed balance analysis of two angular coupler designs, show that significant efficiency improvements are possible with these couplers, and demonstrate initial fabrication of one coupler design. A new light-management design could allow single-junction GaAs solar cells to reach power-conversion efficiencies as high as 38%. This is the finding of Emily Kosten and co-workers from the California Institute of Technology in the USA and FOM Institute AMOLF in The Netherlands, who studied the impact of limiting the angles of light emission in very thin light trapping GaAs solar cells. Reducing the angles of light emission allows for cells as thin as 50 nm due to extreme light trapping, and recycling of photons within the cells gives high efficiencies. In addition, the researchers modeled designs for limiting the angles of light emission and fabricated the necessary optical microstructures for one such design.
Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis (1993)

In analyzing the region of the Saccharopolyspora erythraea chromosome responsible for the biosynthesis of the macrolide antibiotic erythromycin, we identified a gene, designated eryK, located about 50 kb downstream of the erythromycin resistance gene, ermE. eryK encodes a 44-kDa protein which, on the basis of comparative analysis, belongs to the P450 monooxygenase family. An S. erythraea strain disrupted in eryK no longer produced erythromycin A but accumulated the B and D forms of the antibiotic, indicating that eryK is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis.
Structural Optimization of Air-Guiding Photonic Bandgap Fibers for Realizing Ultimate Low Loss Waveguides (2008)

In this paper, we investigate the ultimate low loss property for several realistic core shapes in triangular-type air-guiding photonic bandgap fibers (PBGFs) through a full-vector modal solver based on the finite element method. We show that the surface mode free condition is expressed as a normalized silica-ring thickness T = 0.5 for any core size and the cladding structural parameters, regardless the core radius of the silica-ring is one of the main factors of dominating the surface mode's condition, and the wavelength range of the PBG changes on varying the structural parameters of the cladding. Moreover, we propose a novel type of PBGF without surface mode, which exhibits lower scattering losses caused by surface roughness of the silica-ring in comparison to 19 cell-core PBGFs and suppresses the mode coupling between fundamental-like and higher order modes when compared to 37 cell-core PBGFs.
Power signature analysis (2003)

Nonintrusive load monitoring (NILM) can determine operating schedule of electrical loads in a target system from measurements made at a centralized location, such as the electric utility service entry. NILM is an ideal platform for extracting useful information about any system that uses electromechanical devices. It has a low installation cost and high reliability because it uses a bare minimum of sensors. It is possible to use modem state and parameter estimation algorithms to verify remotely the "health" of electromechanical loads by using NILM to analyze measured waveforms associated with the operation of individual loads. NILM can also monitor the operation of the electrical distribution system itself, identifying situations where two or more otherwise healthy loads interfere with each other's operation through voltage waveform distortion or power quality problems. Strategies for nonintrusive monitoring have developed over the last 20 years. Advances in computing technology make a new wealth of computational tools useful in practical, field-based NILM systems. This article reviews techniques for high-performance nonintrusive load and diagnostic monitoring and illustrates key points with results from field tests.
Vitamin A and carotenoids in human milk (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVitamin A and carotenoids in human milkYoungnam Kim, Catherine English, Peter Reich, Leonard E. Gerber, and Kenneth L. SimpsonCite this: J. Agric. Food Chem. 1990, 38, 10, 1930–1933Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://doi.org/10.1021/jf00100a011RIGHTS & PERMISSIONSArticle Views234Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (574 KB) Get e-Alertsclose Get e-Alerts
Applicability of coating techniques for the production of organic field effect transistors (2003)

Polymer electronics circuits based on organic field effect transistors (OFETs) have the prospect of becoming low cost products. This relies mainly on the fact that the polymers are solution processable and thus can be treated with printing and coating techniques. We investigate the applicability of different coating techniques for those layers in the OFET which do not necessarily need to be patterned, i.e. the semiconductor and dielectric insulator. The results are given in respect of layer quality and transistor operation. The investigated methods are doctor blading and screen printing which have the potential for roll-to-roll processing. Both methods are compared to spin coating, which is well established but restricted to batch processing.
A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM) (2001)

Motivated by the vast amount of information that is rapidly accumulating about the human brain in digital form, we embarked upon a program in 1992 to develop a four-dimensional probabilistic atlas and reference system for the human brain. Through an International Consortium for Brain Mapping (ICBM) a dataset is being collected that includes 7000 subjects between the ages of eighteen and ninety years and including 342 mono- and dizygotic twins. Data on each subject includes detailed demographic, clinical, behavioural and imaging information. DNA has been collected for genotyping from 5800 subjects. A component of the programme uses post-mortem tissue to determine the probabilistic distribution of microscopic cyto- and chemoarchitectural regions in the human brain. This, combined with macroscopic information about structure and function derived from subjects in vivo, provides the first large scale opportunity to gain meaningful insights into the concordance or discordance in micro- and macroscopic structure and function. The philosophy, strategy, algorithm development, data acquisition techniques and validation methods are described in this report along with database structures. Examples of results are described for the normal adult human brain as well as examples in patients with Alzheimer's disease and multiple sclerosis. The ability to quantify the variance of the human brain as a function of age in a large population of subjects for whom data is also available about their genetic composition and behaviour will allow for the first assessment of cerebral genotype-phenotype-behavioural correlations in humans to take place in a population this large. This approach and its application should provide new insights and opportunities for investigators interested in basic neuroscience, clinical diagnostics and the evaluation of neuropsychiatric disorders in patients.
Induction of stable long‐term depression in vivo in the hippocampal–prefrontal cortex pathway (1999)

We studied excitatory field potentials in the medial prefrontal cortex (mPFC, prelimbic area) to electrostimulation of the ventral hippocampus (CA1/subicular region) in the anaesthetized rat. Nine hundred stimulus trains (5 pulses at 250 Hz) applied at 1 Hz to the ventral hippocampus significantly and persistently depressed the amplitude and maximal slope ( approximately 55% for each index) of the prelimbic field potentials, but did not change the latency of the maximal slope or peak negativity. Twelve stimulus trains (50 pulses at 250 Hz) applied subsequently at 0.1 Hz restored the depression back to control level, and this reversible depression was maintained for at least 13 h. Cumulative depressive effects on the prelimbic field potential amplitude and maximal slope were observed upon addition of stimulus trains in the hippocampus. An important implication of the results is that the direct pathway from the hippocampus to the mPFC in the rat retains long-term depression (LTD) as a neuroplastic form in vivo. This form could cooperate with long-term potentiation (LTP) and such a bi-directional synaptic plasticity in the prefrontal cortex contributes to how cortical neural networks store information.
Design methodology for fault tolerant ASICs (2012)

The sensitivity of application specific integrated circuits (ASICs) to the single event effects (SEE) can induce failures of the systems which are exposed to increased radiation levels in the space and on the ground. This paper presents a design methodology for a full fault tolerant ASIC that is immune to the single event upsets (SEU) in sequential logic, the single event transients (SET) in combinational logic and the single event latchup (SEL). The dual modular redundancy (DMR) and a SEL power-switch (SPS) are the basis for a modified ASIC design flow. Measurement results have proven the correct functionality of DMR and SPS circuits, as well as a high fault tolerance of implemented ASICs along with moderate overhead in respect of power consumption and occupied silicon area.
Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. (1993)

In an earlier report, we used differential cloning to identify genes that might be critical in controlling arterial neointima formation (Giachelli, C., N. Bae, D. Lombardi, M. Majesky, and S. Schwartz. 1991. Biochem. Biophys. Res. Commun. 177:867-873). In this study, we sequenced the complete cDNA and conclusively identified one of these genes, 2B7, as rat osteopontin. Using immunochemistry and in situ hybridization, we found that medial smooth muscle cells (SMC) in uninjured arteries contained very low levels of osteopontin protein and mRNA. Injury to either the adult rat aorta or carotid artery using a balloon catheter initiated a qualitatively similar time-dependent increase in both osteopontin protein and mRNA in arterial SMC. Expression was transient and highly localized to neointimal SMC during the proliferative and migratory phases of arterial injury, suggesting a possible role for osteopontin in these processes. In vitro, basic fibroblast growth factor (bFGF), transforming growth factor-beta (TGF-beta), and angiotensin II (AII), all proteins implicated in the rat arterial injury response, elevated osteopontin expression in confluent vascular SMC. Finally, we found that osteopontin was a novel component of the human atherosclerotic plaque found most strikingly associated with calcified deposits. These data implicate osteopontin as a potentially important mediator of arterial neointima formation as well as dystrophic calcification that often accompanies this process.
PSMA‐targeted SPECT agents: Mode of binding effect on in vitro performance (2012)

We have demonstrated that a PSMA-targeted SPECT agent can be assembled efficiently using copper-less click chemistry. In addition, we demonstrated that mode of binding has an effect on internalization and percent uptake of PSMA-targeted SPECT agents; with the irreversible targeting agent demonstrating superior uptake and internalization in PSMA+ cells. The approach demonstrated in this work now supports a modular approach for the assembly of PSMA-targeted imaging and therapeutic agents.
Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data. (1975)

Abstract Fifteen acidic antiinflammatory agents, for which some clinical data have previously been published, have been examined for their potency in the carrageenan-induced rat foot edema test, and for their acidity (pKa) and partition coefficients. Published serum half-life data and daily clinical (anti-arthritic) dose have been tabulated for these drugs and correlations between these various parameters are discussed. The rat foot edema carrageenan test has proved to be a fairly reliable predictor of clinical dose for most acidic antiinflammatory agents of moderate serum half-life.
Bacteroides plebeius sp. nov. and Bacteroides coprocola sp. nov., isolated from human faeces (2005)

Nine strains of Gram-negative, anaerobic rod were isolated from human faeces. Based on phylogenetic analysis and specific phenotypic characteristics, these strains were included within the Bacteroides cluster and were divided into two clusters. Strains from the two clusters showed 16S rRNA gene sequence similarities of 90.4 and 92.7% to the nearest recognized species, Bacteroides vulgatus. The strains also formed two clusters exhibiting a 16S rRNA gene sequence divergence of approximately 6%. DNA-DNA hybridization studies confirmed that the two novel strain clusters were distinct from each other. Based on the phenotypic and phylogenetic findings, two novel species, Bacteroides plebeius sp. nov. and Bacteroides coprocola sp. nov., are proposed, each representing one of the two strain clusters. The DNA G+C content of the type strains were 43.9 mol% for B. plebeius (M12(T)=JCM 12973(T)=DSM 17135(T)) and 42.4 mol% for B. coprocola (M16(T)=JCM 12979(T)=DSM 17136(T)).
Face Recognition by Exploring Information Jointly in Space, Scale and Orientation (2010)

Information jointly contained in image space, scale and orientation domains can provide rich important clues not seen in either individual of these domains. The position, spatial frequency and orientation selectivity properties are believed to have an important role in visual perception. This paper proposes a novel face representation and recognition approach by exploring information jointly in image space, scale and orientation domains. Specifically, the face image is first decomposed into different scale and orientation responses by convolving multiscale and multiorientation Gabor filters. Second, local binary pattern analysis is used to describe the neighboring relationship not only in image space, but also in different scale and orientation responses. This way, information from different domains is explored to give a good face representation for recognition. Discriminant classification is then performed based upon weighted histogram intersection or conditional mutual information with linear discriminant analysis techniques. Extensive experimental results on FERET, AR, and FRGC ver 2.0 databases show the significant advantages of the proposed method over the existing ones.
Joint L‐/C‐Band Code and Carrier Phase Linear Combinations for Galileo (2008)

Linear code combinations have been considered for suppressing the ionospheric error. In the L‐band, this leads to an increased noise floor. In a combined L‐ and C‐band (5010–5030 MHz) approach, the ionosphere can be eliminated and the noise floor reduced at the same time. Furthermore, combinations that involve both code‐ and carrier‐phase measurements are considered. A new L‐band code‐carrier combination with a wavelength of 3.215 meters and a noise level of 3.92 centimeters is found. The double difference integer ambiguities of this combination can be resolved by extending the system of equations with an ionosphere‐free L‐/C‐band code combination. The probability of wrong fixing is reduced by several orders of magnitude when C‐band measurements are included. Carrier smoothing can be used to further reduce the residual variance of the solution. The standard deviation is reduced by a factor 7.7 if C‐band measurements are taken into account. These initial findings suggest that the combined use of L‐ and C‐band measurements, as well as the combined code and phase processing are an attractive option for precise positioning.
Highly Sensitive Detection of Hybridization of Oligonucleotides to Specific Sequences of Nucleic Acids by Application of Fluorescence Resonance Energy Transfer (2000)

We show a new application of fluorescence resonance energy transfer (FRET) in two stages to detect specific sequences of nucleic acids. In the first stage, two fluorescently tagged oligonucleotides hybridize with a complementary target molecule to produce FRET. The sequences of the oligonucleotides and spectral properties of fluorophores are chosen to provide a basis for an efficient energy transfer. In the next step, the specificity of hybridization is tested by competition of labeled probes with an excess of unlabeled oligonucleotides of the same sequence. The resulting emission spectra, one obtained in the excess of unlabeled donor probe and the other produced in the excess of unlabeled acceptor probe, are compared with the spectrum from the first stage to look for differences in the emission pattern of the fluorescent labels. We show that it is possible to detect the existence of specific hybrids composed of the two probes and complementary target molecule even in very unfavorable conditions, such as the presence of unhybridized probes in the final reaction mixture, secondary nonacceptor quenching of donor probe fluorescence, and strong background emission of acceptor produced by its direct excitation with a donor excitation light.
Study of the Total Synthesis of (−)-Exiguolide (2012)

In this article, we disclose the various routes and strategies we had to explore before finally achieving the total synthesis of (-)-exiguolide ((-)-1). Two first types of approaches were set, both relying on the Trost's domino ene-yne coupling/oxa-Michael reaction that we choose for its ability to control the geometry of the methylacrylate-bearing tetrahydropyrane ring B. In our first approach, we expected to assemble the two main fragments (C14-C21 and C1-C13) by creating the C13-C14 bond through a palladium(0)-catalyzed cross-coupling, but this step failed, unfortunately. In the second approach, which was more linear, we created the C16-C17 bond through condensation of a lithium acetylide on a Weinreb amide, and we assembled the C1-C5 and C6-C21 subunits through Trost's domino ene-yne coupling/oxa-Michael reaction. These two approaches served us to design an ameliorated third strategy, which finally led to the total synthesis of (-)-exiguolide.
Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression (2014)

Antiangiogenic therapies targeting VEGFA have been commonly used in clinics to treat cancers over the past decade. However, their clinical efficacy has been limited, with drawbacks including acquisition of resistance and activation of compensatory pathways resulting from elevated circulating VEGFB and placental growth factor (PlGF). To bypass these disadvantages, we developed a novel glycosylated soluble decoy receptor fusion protein, VEGF-Grab, that can neutralize VEGFA, VEGFB, and PlGF. VEGF-Grab has the second and third immunoglobulin (Ig)-like domains of VEGF receptor 1 (VEGFR1) fused to IgG1 Fc, with three potential glycosylation sites introduced into the third Ig-like domain of VEGF-Grab by mutagenesis. Compared with VEGF-Trap, VEGF-Grab showed more potent decoy activity against VEGF and PlGF, mainly attributed to the VEGFR1 backbone. Most importantly, the negatively charged O-glycans attached to the third Ig-like domain of VEGFR1 counterbalanced the originally positively charged VEGFR1 backbone, minimizing nonspecific binding of VEGF-Grab to the extracellular matrix, and resulting in greatly improved pharmacokinetic profile. These advancements led to stronger and more durable antiangiogenic, antitumor, and antimetastatic efficacy in both implanted and spontaneous tumor models as compared with VEGF-Trap, while toxicity profiles were comparable with VEGF-Trap. Collectively, our results highlight VEGF-Grab as a promising therapeutic candidate for further clinical drug development.