gebhart/patrepeval huggingface dataset:
Modulation of the Fce Receptor I Signaling by Tyrosine Kinase Inhibitors: Search for Therapeutic Targets of Inflammatory and Allergy Diseases (2004)

Mast cells and basophils are major effector cells in the immunoglobulin E (IgE)-dependent allergic reactions as well as in the innate immunity. They are distributed throughout the body and, upon allergen exposure, are stimulated via the high affinity IgE receptor (FcepsilonRI) to release several pro-inflammatory mediators such as leukotrienes, immunoregulatory cytokines and histamine. FcepsilonRI-mediated signaling is initiated by tyrosine phosphorylation of FcepsilonRI subunits by Src family kinase Lyn, which is followed by an activation of Syk/Zap family kinase Syk. The activated kinases then in turn phosphorylate and activate other enzymes [phospholipase Cgamma (PLCgamma) isoforms, phosphatidylinositol-3 kinase (PI3K) isoforms, protein kinase C (PKC) isoforms, Bruton's tyrosine kinase (Btk) and others], adaptors [linker for activation of T cells (LAT), Cbl, Grb2 and others] and GTP exchange factors/GTPases (Vav, Ras, Rho, and others), and subsequently induce the mobilization of stored and extracellular Ca(2+). These and other biochemical events lead within seconds and minutes to the secretory response and later to the production of chemokines. This review is focused on the use of tyrosine kinase inhibitors specific for Src family kinases (PP1/PP2, SU6656 and CT5269), Syk kinase (piceatannol, ER-27319 and BAY 61-3606) and Btk (terreic acid and LFM-A13) for a modulation of FcepsilonRI-mediated signaling in mast cells. Potential use of the inhibitors in the treatment of inflammatory and allergy diseases as well as future directions in the development of highly specific tyrosine kinases inhibitors of new generations and their use in an intended modulation of mast cell signaling are discussed.
An efficient message authentication scheme for link state routing (2002)

We study methods for reducing the cost of secure link state routing. In secure link state routing, routers may need to verify the authenticity of many routing updates, and some routers such as border routers may need to sign many routing updates. Previous work such as public-key based schemes are very expensive computationally or have certain limitations. This paper presents an efficient solution, based on a detection-diagnosis-recovery approach, for the link state routing update authentication problem. Our scheme is scalable to handle large networks, applicable to routing protocols that use multiple-valued cost metrics, and applicable even, when link states change frequently.
CELL PROLIFERATION KINETICS IN THE GASTROINTESTINAL TRACT OF MAN. I. CELL RENEWAL IN COLON AND RECTUM* (1963)

third patient with a carcinoma of the rectum 8 cm proximal to the anal orifice was studied. Although all patients had carcinoma and known metastases, and had recently lost weight, they were fairly well-nourished at the time of these studies.
A natural acoustic front-end for Interactive TV in the EU-Project DICIT (2009)

ldquoDistant-talking Interfaces for Control of Interactive TVrdquo (DICIT) is a European Union-funded project whose main objective is to integrate distant-talking voice interaction as a complementary modality to the use of a remote control in interactive TV systems. Hands-free and seamless control enables a natural user-system interaction providing a suitable means to greatly ease information retrieval. In the given living room scenario the system recognizes commands spoken by multiple and possibly moving users, even in the presence of background noise and TV surround audio. This paper focuses on the multichannel acoustic frontend (MCAF) processing for acoustic scene interpretation which is based on the combination of multi-channel acoustic echo cancellation, blind source separation, beamforming, acoustic event classification, and multiple speaker localization. The fully functional DICIT prototype consists of the MCAF, automatic speech recognition, natural language understanding, mixed-initiative dialogue and satellite connection.
Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescencein situhybridization study in mice (2005)

The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a segregation device. The highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control.
Continuous progression of radiological destruction in seropositive rheumatoid arthritis. (1997)

Seropositive RA is a chronic disease still leading to continuous progression of joint damage 20 years after onset.
Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides. (1988)

Allene oxides are unstable epoxides that have been implicated as intermediates in the biotransformation of hydroperoxyicosatetraenoic acids and related hydroperoxides to ketols and cyclopentenones. Direct proof of the structure of the putative allene oxide intermediates has been hampered by their extreme instability under the conditions of their biosynthesis (t1/2 approximately 15-30 sec at 0 degree C and pH 7.4). We now report the isolation and structural elucidation of allene oxides prepared from the (13S)-hydroperoxides of linoleic and linolenic acids. The compounds were biosynthesized by using a very active enzyme preparation from flaxseed. After a 5-sec incubation at 0 degrees C, the allene oxide metabolites were extracted and purified as the methyl ester derivatives at -15 degrees C. The structures were established by UV, CD, NMR, and oxygen-18 labeling experiments. 12,13(S)-Oxido-9Z,11-octadecadienoic acid is derived from linoleic acid, and 12,13(S)-oxido-9Z,11,15Z-octadecatrienoic acid is from linolenic acid. Analysis of the breakdown products formed on exposure to water led to identification of hydrolysis and cyclization products previously characterized as enzymic derivatives of the (13S)-hydroperoxides in flaxseed. Our results give direct proof of the structure of the allene oxide intermediates and should facilitate further investigation of the metabolism of this class of epoxide to prostaglandins, clavulones, and other stable end products.
Presenilin, Notch, and the genesis and treatment of Alzheimer's disease (2001)

Elucidation of the proteolytic processing of the amyloid β-protein precursor (APP) has revealed that one of the two proteases (γ-secretase) that cleave APP to release amyloid β-protein (Aβ) is likely to be presenilin. Presenilin also mediates the γ-secretase-like cleavage of Notch receptors to enable signaling by their cytoplasmic domains. Therefore, APP and Notch may be the first identified substrates of a unique intramembranous aspartyl protease that has presenilin as its active-site component. In view of the evidence for a central role of cerebral build-up of Aβ in the pathogenesis of Alzheimer's disease, this disorder appears to have arisen in the human population as a late-life consequence of the conservation of a critical developmental pathway.
Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. (1991)

Cytokine gene transcription has been analyzed by direct analysis of RNA obtained from mouse heterotopic cardiac transplants. The level of expression of the cytokine genes was assessed using semiquantitative polymerase chain reaction (PCR). Expression of the cytokines investigated fell into three groups. The first group included interleukin 1 beta (IL-1 beta), IL-5, IL-6, and interferon gamma (IFN gamma). These genes were expressed in normal heart tissue at low level and were upregulated following both syngeneic and allogeneic transplantation. Genes in the second group (IL-1 alpha, IL-3) were not expressed at detectable levels in normal heart but were induced following either syngeneic or allogeneic heart grafting. IL-2, IL-4, and tumor necrosis factor beta (IFN beta) comprised the third group and these cytokines were expressed only in allogeneic grafts after transplantation.
Poly(ADP-ribose) polymerase (PARP) decreases apoptosis and stimulates growth of HeLa cells by decreasing stability of P2X7 mRNA (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

2692 

Introduction: The P2X7 receptor is a membrane-bound ligand-operated channel, and in epithelia its main function is regulation of apoptosis. Recent studies showed that protein and mRNA levels of P2X7 are lower in cancer epithelial tissues than in the corresponding normal tissues, and that P2X7-mediated apoptosis is abrogated in epithelial cancer cells compared to normal cells. These data suggest that decreased expression of P2X7 predisposes epithelial cells to the effects of carcinogens and may lead to the development of cancer. In this study, we tested the hypothesis that regions of the 3’UTR of P2X7 mRNA confer instability to the transcript. Methods: Normal (hEVEC) and cancerous human uterine cervical epithelial cells (HeLa) were transfected with a reporter plasmid containing luciferase - 3’ untranslated region (3’UTR)-P2X7 cDNA. RNA-Protein Pull-Down experiments involved incubation of biotin-labeled, in-vitro - transcribed (3’UTR)-P2X7 mRNA with nuclear extract of HeLa cells, followed by fractionation using SDS-PAGE. RNA was quantified by one-step qPCR and levels were normalized to GAPDH. Apoptosis was quantified using commercially available kits. Results: (1) Steady-state levels of luciferase mRNA were higher in hEVEC cells transfected with the 3’UTR-P2X7-luciferase vector than in HeLa cells transfected with the reporter plasmid. (2) Pull-Down experiments using (3’UTR)-P2X7 mRNA revealed significant interaction with a 115 kDa band in nuclear extracts of HeLa but only minimally in hEVEC cells. (3) Mass spectrometry of the band revealed the presence of human poly(ADP-ribose) polymerase (PARP). (4) Treatment of HeLa cells with the PARP inhibitor 4-HQN resulted in a dose-related increase in P2X7 mRNA and apoptosis. Conclusions: The data suggest that (1) cancerous epithelial cells degrade P2X7 mRNA by activation of instability domains located at the 3’UTR of the P2X7; (2) PARP interacts with transcribed P2X7 mRNA and de-stabilizes the (3’UTR)-P2X7 mRNA; (3) inhibition of PARP augments P2X7-related apoptosis by increasing stability of the P2X7 mRNA. Support: NIH (AG15955) and CytoCore Inc. unrestricted grant to GIG.
The role of the SMN gene in proximal spinal muscular atrophy (1998)

Childhood spinal muscular atrophy (SMA) is a common recessive autosomal disorder that results in degeneration of lower motor neurons. The identification of the disease gene, Survival of Motor Neuron (SMN), was a major advance in understanding the molecular basis underlying this devastating neuromuscular disease. This finding has greatly improved the genetic counselling of SMA families. Recently, biochemical studies demonstrated its involvement in the biogenesis of spliceosomal snRNPs, suggesting a critical role of SMN in RNA processing. Surprisingly, other studies showed a putative role of SMN in an anti-apoptotic pathway involving Bcl-2. The function of SMN protein is not fully understood. These observations emphasized the difficulty in elucidating the function of any novel protein. Therefore, multidisciplinary approaches are required to understand the pathogenesis of SMA.
Mixed-Culture Cultivation of Edible and Medicinal Mushroom Tremella fudformis Berk. (Phragmobasidiomycetes) on Synthetic Logs (2002)

Tremella fudformis (white jelly mushroom, yin er), an important culinary and medicinal mushroom in China and Taiwan, is a fairly new adventure in North America. Cultivation of T. fudformis focusing on synthetic logs is described.
Hydrosilylation of 1‐dodecene on Nanostructured Porous Silicon Surface: Role of Current Density and Stabilizing Agent (2009)

We report the formation of nanostructured PS on boron doped p‐type silicon wafer (100) by electrochemical anodization using aqueous hydrofluoric acid and isopropyl alcohol solution at different current densities 20 mAcm−2 and 50 mAcm−2 with pore size being 20–30 nm and 50–60 nm, respectively. For organic functionalization of PS surface 1‐Dodecene treatment under UV light was done. PL, FTIR and XPS studies have been carried out to characterize the PS after surface modification using dodecene. Stability studies were performed under normal ambience and humid condition for as‐anodized (Fresh PS) and dodecene‐treated samples. It is observed that the dodecene functionalized samples were more stable than as‐anodized porous silicon. The present study demonstrates that nanoporous silicon can provide chemically modified stable and high surface area for the sensing applications of PS.
An anthracene derivative carrying ferrocenyl moieties at its 9 and 10 positions as a new electrochemically active threading intercalator (2002)

A ferrocenyl anthracene derivative (FAN) was synthesized by connecting ferrocene moieties to the amino termini of its substitutents at 9 and 10 positions, aiming at an improved hybridization indicator. Spectrophotometric experiments revealed that FAN can bind to double stranded DNA (dsDNA) by threading intercalation. Evaluation of FAN in the dsDNA preference as hybridization indicator revealed that FAN has higher preference for dsDNA than ferrocenyl naphthalene diimdie (FND) reported previously.
Influence of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Sulfonylurea Drugs (2009)

Sulfonylurea drugs including chlorpropamide, gliclazide, tolbutamide, glipizide, glibenclamide (glyburide) and glimepiride are the most widely used oral hypoglycaemic agents in people with type 2 diabetes. This review investigates the impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of sulfonylurea drugs. CYP2C9 is the major enzyme involved in sulfonylurea drug metabolism. CYP2C9 variant allele carriers have significant lower apparent clearance of these medicines. CYP2C19 genotype is more influential for gliclazide pharmacokinetics when compared to CYP2C9. Sulfonylurea pharmacodynamics is affected by several genes. Sulfonylurea receptor 1 (SUR1, ABCC8 gene) and K+ inward rectifier Kir6.2 (KCNJ11) have been correlated to significant variation in sulfonylurea response. Diabetics with the SUR1 exon 33 G allele are more sensitive to gliclazide and the rs5210 variant of the KCNJ11 gene was associated with improved clinical efficacy of gliclazide. Carriers of Transcription factor 7-like 2 (TCF7L2) variants are more likely to fail sulfonylurea therapy. On the other hand, patients with HNF-1alpha mutations had a significant greater response to gliclazide when compared to those with type 2 diabetes. The Arg972 polymorphism of insulin receptor substrate 1 (IRS1) may lead to secondary failure of sulfonylurea therapy. Calpain 10 gene (CAPN10) polymorphism has also been linked to sulfonylurea drug response. Despite the available evidence, larger population studies that investigate the pharmacokinetics and pharmacodynamics of sulfonylurea drugs are needed to investigate the influence of key SNPs amidst all potential contributing factors to variability in response to these which inturn will provide information to optimise sulfonylurea use in people with diabetes.
New advances in vaccine delivery systems. (1993)

Successful application of the next generation of vaccines will require that protection be induced with a minimal number of administrations, and that a practical approach to inducing immunity at mucosal surfaces be developed. For these reasons, vaccine-containing microspheres were formulated from the biodegradable and biocompatible copolymer poly(DL-lactide-co-glycolide) [DL-PLG]. Subcutaneous immunization of mice with 1- to 10-microns microspheres containing a toxoid vaccine of staphylococcal enterotoxin B (SEB) induced a 500-fold potentiation of the circulating antitoxin response. Strong adjuvant activity was dependent on the microspheres being no more than 10 microns in diameter and required that the antigen was within the particles. The rate of DL-PLG biodegradation is a function of the ratio of lactide to glycolide, and the co-injection of SEB toxoid microspheres formulated with two different DL-PLG ratios stimulated both a primary and an anamnestic secondary antitoxin response. When it was administered by the oral or intratracheal (IT) route, microencapsulated SEB toxoid was found to be effective in the induction of concurrent circulating and disseminated mucosal antibody responses. Female rhesus macaques immunized with a microencapsulated simian immunodeficiency virus (SIV) vaccine produced high levels of circulating anti-SIV antibodies, and following oral or IT boosting, specific antibodies were found in vaginal wash fluids. Vaginal challenge with viable homologous SIV resulted in the infection of three out of four nonimmunized but only one out of seven microsphere-immunized macaques. Thus, DL-PLG microspheres are a promising approach to the delivery of vaccines, combining adjuvant activity with controlled release and effective presentation to mucosally associated lymphoid tissues (MALT).
New for Congress 2011 (2011)

Abstract New editions of the BSAVA Manuals of Canine and Feline Oncology, Rehabilitation, Supportive and Palliative Care, Reproduction and Neonatology, and Ultrasonography planned for Congress 2011.
Role for low-affinity receptor for IgE (CD23) in normal and leukemic B- cell proliferation (1994)

CD23 gene is overexpressed and abnormally regulated in the most frequent adult leukemic disorder, B chronic lymphocytic leukemia (B-CLL). Switch on and off in the upregulation of surface CD23 expression consistently occurs in the early stage of normal B-cell activation, suggesting a key role for CD23 in this process. We show here that, after ligation of mlg in the presence of interleukin-4, the increase of CD23 protein precedes B-cell DNA synthesis and mainly results from the strong induction of CD23 type-B isoform. Exposure of normal B cells to conventional or phosphorothioate-derivatized CD23 antisense oligonucleotides (predominantly type B) significantly augments B-cell proliferation induced by antigen receptor stimulation or direct contact with activated T cells. Unexpectedly, CD23 antisense, but not sense, oligonucleotides specifically enhance rather than suppress CD23 expression on B cells. Finally, a selective increase in CD23 type-B expression provokes the entry of resting (Go) CLL B cells into G1 and S phase of the cell cycle in the absence of any other stimulus, whereas it synergizes with tumor necrosis factor-alpha to increase the number of activated B cells. These results provide compelling evidence that CD23 represents an important molecule directly involved in the process of normal or leukemic B-cell activation and growth.
Levulinic Acid as a Basic Chemical Raw Material (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLevulinic Acid as a Basic Chemical Raw MaterialReid H. LeonardCite this: Ind. Eng. Chem. 1956, 48, 8, 1330–1341Publication Date (Print):August 1, 1956Publication History Published online1 May 2002Published inissue 1 August 1956https://pubs.acs.org/doi/10.1021/ie50560a033https://doi.org/10.1021/ie50560a033research-articleACS PublicationsRequest reuse permissionsArticle Views2051Altmetric-Citations159LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
High-order Nyström schemes for efficient 3-D capacitance extraction (1998)

Article Free Access Share on High-order Nyström schemes for efficient 3-D capacitance extraction Authors: Sharad Kapur Bell Laboratories, Lucent Technologies, Murray Hill, NJ Bell Laboratories, Lucent Technologies, Murray Hill, NJView Profile , David E. Long Bell Laboratories, Lucent Technologies, Murray Hill, NJ Bell Laboratories, Lucent Technologies, Murray Hill, NJView Profile Authors Info & Claims ICCAD '98: Proceedings of the 1998 IEEE/ACM international conference on Computer-aided designNovember 1998 Pages 178–185https://doi.org/10.1145/288548.288604Published:01 November 1998Publication History 9citation205DownloadsMetricsTotal Citations9Total Downloads205Last 12 Months7Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Applications of adaptive filtering to ECG analysis: noise cancellation and arrhythmia detection (1991)

Several adaptive filter structures are proposed for noise cancellation and arrhythmia detection. The adaptive filter essentially minimizes the mean-squared error between a primary input, which is the noisy ECG, and a reference input, which is either noise that is correlated in some way with the noise in the primary input or a signal that is correlated only with ECG in the primary input. Different filter structures are presented to eliminate the diverse forms of noise: baseline wander, 60 Hz power line interference, muscle noise, and motion artifact. An adaptive recurrent filter structure is proposed for acquiring the impulse response of the normal QRS complex. The primary input of the filter is the ECG signal to be analyzed, while the reference input is an impulse train coincident with the QRS complexes. This method is applied to several arrhythmia detection problems: detection of P-waves, premature ventricular complexes, and recognition of conduction block, atrial fibrillation, and paced rhythm.
An AIDS-Like Condition Induced in Baboons by HIV-2 (1994)

Six baboons (Papio cynocephalus) were intravenously inoculated with the human immunodeficiency virus-type 2 (HIV-2) strain HIV-2UC2. All seroconverted within 6 weeks after inoculation; five animals became persistently infected. Four developed lymphadenopathy, and three of the animals had CD4+ T cell loss within 18 to 24 months after inoculation. One of these baboons, showing severe clinical symptoms, showed at necropsy widespread dissemination of virus with follicular depletion in the lymph nodes, extensive fibromatosis involving lymphoid and nonlymphoid tissues, and lymphocytic interstitial pneumonitis. Another animal is cachectic and exhibited lymphoid follicular lysis and fibrous skin lesions. Other baboons inoculated with a second strain, HIV-2UC14, have shown evidence of persistent infection. HIV-2 infection of baboons provides a valuable animal model for studying HIV persistence and pathogenesis and for evaluating approaches to antiviral therapies.