gebhart/patrepeval huggingface dataset:
APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle (1997)

The molecular mechanisms that link cell-cycle controls to the mitotic apparatus are poorly understood. A component of the Saccharomyces cerevisiae spindle, Ase1, was observed to undergo cell cycle-specific degradation mediated by the cyclosome, or anaphase promoting complex (APC). Ase1 was degraded when cells exited from mitosis and entered G 1 . Inappropriate expression of stable Ase1 during G 1 produced a spindle defect that is sensed by the spindle assembly checkpoint. In addition, loss of ASE1 function destabilized telophase spindles, and expression of a nondegradable Ase1 mutant delayed spindle disassembly. APC-mediated proteolysis therefore appears to regulate both spindle assembly and disassembly.
Highly scalable non-volatile resistive memory using simple binary oxide driven by asymmetric unipolar voltage pulses (2005)

Simple binary-TMO (transition metal oxide) resistive random access memory named as OxRRAM has been fully integrated with 0.18/spl mu/m CMOS technology, and its device as well as cell properties are reported for the first time. We confirmed that OxRRAM is highly compatible with the conventional CMOS process such that no other dedicated facility or process is necessary. Filamentary current paths, which are switched on or off by asymmetric unipolar voltage pulses, made the cell properties insensitive to cell or contact size promising high scalability. Also, OxRRAM showed excellent high temperature performance, even working at 300/spl deg/C without any significant degradation. With optimized TMO material and electrodes, OxRRAM operated successfully under 3V bias voltage and 2mA switching current at a TMO cell size smaller than 0.2/spl mu/m/sup 2/.
Cell biological mechanisms of multidrug resistance in tumors. (1994)

Multidrug resistance (MDR) is a generic term for the variety of strategies tumor cells use to evade the cytotoxic effects of anticancer drugs. MDR is characterized by a decreased sensitivity of tumor cells not only to the drug employed for chemotherapy but also to a broad spectrum of drugs with neither obvious structural homology nor common targets. This pleiotropic resistance is one of the major obstacles to the successful treatment of tumors. MDR may result from structural or functional changes at the plasma membrane or within the cytoplasm, cellular compartments, or nucleus. Molecular mechanisms of MDR are discussed in terms of modifications in detoxification and DNA repair pathways, changes in cellular sites of drug sequestration, decreases in drug-target affinity, synthesis of specific drug inhibitors within cells, altered or inappropriate targeting of proteins, and accelerated removal or secretion of drugs.
Enhanced Photoluminescence and Solar Cell Performance via Lewis Base Passivation of Organic–Inorganic Lead Halide Perovskites (2014)

Organic-inorganic metal halide perovskites have recently emerged as a top contender to be used as an absorber material in highly efficient, low-cost photovoltaic devices. Solution-processed semiconductors tend to have a high density of defect states and exhibit a large degree of electronic disorder. Perovskites appear to go against this trend, and despite relatively little knowledge of the impact of electronic defects, certified solar-to-electrical power conversion efficiencies of up to 17.9% have been achieved. Here, through treatment of the crystal surfaces with the Lewis bases thiophene and pyridine, we demonstrate significantly reduced nonradiative electron-hole recombination within the CH(3)NH(3)PbI(3-x)Cl(x) perovskite, achieving photoluminescence lifetimes which are enhanced by nearly an order of magnitude, up to 2 μs. We propose that this is due to the electronic passivation of under-coordinated Pb atoms within the crystal. Through this method of Lewis base passivation, we achieve power conversion efficiencies for solution-processed planar heterojunction solar cells enhanced from 13% for the untreated solar cells to 15.3% and 16.5% for the thiophene and pyridine-treated solar cells, respectively.
Evidence for the Existence of a North Hawaiian Ridge Current* (1998)

Two different datasets are examined for information about the existence and characteristics of the North Hawaiian Ridge Current (NHRC). The pan-Pacific drifter dataset shows a mean NHRC to be confined to within about 100 km of the northern side of the Hawaiian Ridge. A close look at the distribution of the data shows that the current is mostly confined in time to a two-month period in the fall of 1991. MBT data from the Trade Wind Zone Oceanography Pilot Study conducted in the mid-1960s were also examined. Of the 14 cruises with sections north of the Hawaiian Ridge, 5 showed evidence of northwestward flow along the ridge. Of those 5, one was associated with northward meandering of the North Equatorial Current. It is thus suggested that the NHRC is highly intermittent. There are three related hypotheses for the formation of the NHRC, 1) propagation of Rossby waves westward into the ridge, 2) forking of the North Equatorial Current, and 3) as a western boundary current for the eastern Pacific north of 18°N. Evidence is presented pointing to hypothesis 2 as a plausible mechanism.
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination (2013)

All mammalian cells are equipped with large numbers of sensors for protection from various sorts of invaders, who, in turn, are equipped with molecules containing pathogen-associated molecular patterns (PAMPs). Once these sensors recognize non-self antigens containing PAMPs, various physiological responses including inflammation are induced to eliminate the pathogens. However, the host sometimes suffers from chronic infection or continuous injuries, resulting in production of self-molecules containing damage-associated molecular patterns (DAMPs). DAMPs are also responsible for the elimination of pathogens, but promiscuous recognition of DAMPs through sensors against PAMPs has been reported. Accumulation of DAMPs leads to massive inflammation and continuous production of DAMPs; that is, a vicious circle leading to the development of autoimmune disease. From a vaccinological point of view, the accurate recognition of both PAMPs and DAMPs is important for vaccine immunogenicity, because vaccine adjuvants are composed of several PAMPs and/or DAMPs, which are also associated with severe adverse events after vaccination. Here, we review as the roles of PAMPs and DAMPs upon infection with pathogens or inflammation, and the sensors responsible for recognizing them, as well as their relationship with the development of autoimmune disease or the immunogenicity of vaccines.
Systematic reviews and Meta-analysis of Shenmai injection with chemotherapy on treatment of patients with NSCLC (2011)

Objective To evaluate the efficacy and safety of Shenmai injection as an adjunct therapy with chemotherapy for non-small cell lung cancer(NSCLC)compared with NP/GP regimen chemotherapy alone. Methods A comprehensive search strategy was designed to identify all randomized controlled trials(RCTs)comparing Shenmai injection plus NP/GP chemotherapy with NP/GP chemotherapy alone by searching database from 1989 to 2010.A Meta-analysis was employed to evaluate the results of these therapies by RevMan 5.0. Results Seven RCTs including 510 cases were analyzed.Compared with control group,the total OR of efficiency rate of combining Shenmai injection with NP/GP chemotherapy was OR=1.45(95%CI,1.01～2.07),the disease control rate was OR=2.31(95%CI,1.42～3.73).Shenmai injection relieved the symptoms of nausea and vomiting,OR=0.37(95%CI,0.26～0.54).These results showed significant difference(P0.05). Conclusion The logical quality of the trails using Shenmai injection should be improved.Based on the results of Meta-analysis,Shenmai injection has positive effect on chemotherapy in patients with NSCLC in total disease control rate and relieves the symptoms of nausea and vomiting.
Fisher 선형 분류법을 이용한 비정상 트래픽 탐지 (2009)

최근 인터넷을 통한 각종 침해사고 및 트래픽 폭주와 같은 현상이 급격하게 증가함에 따라 네트워크의 비정상적 상황을 조기에 탐지하기 위한 보다 능동적이고 진보적인 기술이 요구되고 있다. 본 논문에서는 캠퍼스 네트워크와 같이 트래픽이 주기적인 특성을 띠는 환경에서 Fisher 선형 분류법(FLD)을 사용하여 트래픽을 두 개의 그룹으로 분류하고, 네트워크에 유입되는 트래픽이 어떤 그룹에 속하는지를 판별하는 기법을 제안한다. 이를 위해 WISE-Mon이라 불리는 트래픽 분석 시스템을 개발하여 캠퍼스 네트워크의 트래픽을 수집하고 이를 모니터링해서 분석을 수행한다. 생성된 트래픽의 training set을 이용하여 비정상 트래픽의 범위를 판단하기 위한 chi-square distribution을 유도하고, FLD를 적용하여 유입되는 트래픽을 두 그룹으로 분리하기 위한 초평면 (hyperplane)을 만든다. 또한 네트워크 내의 트래픽 패턴이 시간이 지남에 따라 계속적으로 변하는 상황을 반영하기 위하여 self-learning 알고리즘을 적용한다. 캠퍼스 네트워크의 트래픽을 적용한 수학적 결과를 통하여 제안하는 기법의 정확성과 신뢰도를 보여준다.
Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells. (2000)

Temporal and spatial regulation of actin-based cytoskeletal organization and focal adhesion formation play an essential role in cell migration. Here, we show that tyrosine phosphorylation of a focal adhesion protein, paxillin, crucially participates in these regulations. We found that tyrosine phosphorylation of paxillin was a prominent event upon integrin activation during epithelial-mesenchymal trans-differentiation and cell migration. Four major tyrosine phosphorylation sites were identified, and two of them were highly inducible upon integrin activation. Paxillin exhibits three distinct subcellular localizations as follows: localization along the cell periphery colocalized with circumferential actin meshworks, macroaggregation at focal adhesions connected to actin stress fibers, and diffuse cytoplasmic distribution. Tyrosine phosphorylation of paxillin localized at the cell periphery and focal adhesions was shown using phosphorylation site-specific antibodies. Mutations in the phosphorylation sites affected the peripheral localization of paxillin and paxillin-containing focal adhesion formation during cell migration and cell-cell collision, accompanied by altered actin organizations. Our analysis indicates that phosphorylation of multiple tyrosines in paxillin alpha is necessary for the proper function of paxillin and is involved in the temporospatial regulation of focal adhesion formation and actin cytoskeletal organization in motile cells.
Molecular features of adult mouse small intestinal epithelial progenitors (2003)

The adult mouse small intestinal epithelium undergoes perpetual regeneration, fueled by a population of multipotential stem cells and oligopotential daughters located at the base of crypts of Lieberkühn. Although the morphologic features of small intestinal epithelial progenitors (SiEPs) are known, their molecular features are poorly defined. Previous impediments to purification and molecular characterization of SiEPs include lack of ex vivo clonigenic assays and the difficulty of physically retrieving them from their niche where they are interspersed between their numerous differentiated Paneth cell daughters. To overcome these obstacles, we used germ-free transgenic mice lacking Paneth cells to obtain a consolidated population of SiEPs with normal proliferative activity. These cells were harvested by laser capture microdissection. Functional genomics analysis identified 163 transcripts enriched in SiEPs compared with Paneth cell-dominated normal crypt base epithelium. The dataset was validated by (i) correlation with the organellar composition of SiEPs versus Paneth cells, (ii) similarities to databases generated from recent mouse hematopoietic and neural stem cell genome anatomy projects, and (iii) laser capture microdissectionreal-time quantitative RT-PCR studies of progenitor cell-containing populations retrieved from the small intestines, colons, and stomachs of conventionally raised mice. The SiEP profile has prominent representation of genes involved in c-myc signaling and in the processing, localization, and translation of mRNAs. This dataset, together with our recent analysis of gene expression in the gastric stem cell niche, discloses a set of molecular features shared by adult mouse gut epithelial progenitors.
TEST AND EVALUATION OF TEXTILE BASED STRETCH SENSORS (2009)

This project has focused on test and evaluation of three different textile sensors. The project includes the development of sensors, the exploration of suitable measurement methods and devices and finally the evaluation of the sensors according to three different applications. Four results were given in order to characterize sensor performance and to verify the effective working ranges. Further the sensors were integrated in three applications such as force sensor, breath sensor and movement sensor in order to test the sensor functionality by application. Future research orientation has suggested by the end of the paper.
Synthesis of 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines and corresponding 3-ones (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 5-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepines and corresponding 3-onesGordon Northrop Walker and Ronald Timothy SmithCite this: J. Org. Chem. 1971, 36, 2, 305–308Publication Date (Print):January 1, 1971Publication History Published online1 May 2002Published inissue 1 January 1971https://pubs.acs.org/doi/10.1021/jo00801a013https://doi.org/10.1021/jo00801a013research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Parameter estimation and tissue segmentation from multispectral MR images (1994)

A statistical method is developed to classify tissue types and to segment the corresponding tissue regions from relaxation time T(1 ), T(2), and proton density P(D) weighted magnetic resonance images. The method assumes that the distribution of image intensities associated with each tissue type can be expressed as a multivariate likelihood function of three weighted signal intensity values (T(1), T(2), P(D)) at each location within that tissue regions. The method further assumes that the underlying tissue regions are piecewise contiguous and can be characterized by a Markov random field prior. In classifying the tissue types, the method models the likelihood of realizing the images as a finite multivariate-mixture function. The class parameters associated with the tissue types (i.e. the weighted intensity means, variances and correlation coefficients of the multivariate function, as well as the number of voxels within regions of the tissue types of are estimated by maximum likelihood. The estimation fits the class parameters to the image data via the expectation-maximization algorithm. The number of classes associated with the tissue types is determined by the information criterion of minimum description length. The method segments the tissue regions, given the estimated class parameters, by maximum a posteriori probability. The prior is constructed by the tissue-region membership of the first- and second-order neighborhood. The method is tested by a few sets of T(1), T(2), and P(D) weighted images of the brain acquired with a 1.5 Tesla whole body scanner. The number of classes and the associated class parameters are automatically estimated. The regions of different brain tissues are satisfactorily segmented.
Changes in Stability upon Charge Reversal and Neutralization Substitution in Staphylococcal Nuclease Are Dominated by Favorable Electrostatic Effects (2003)

Single site mutations that reverse or neutralize a surface charge were made at 22 ionizable residues in staphylococcal nuclease. Unfolding free energies were obtained by guanidine hydrochloride denaturation. These data, in conjunction with previously obtained stabilities of the corresponding alanine mutants, unequivocally show that the dominant contribution to stability for virtually all of the wild-type side chains examined is the electrostatic effect associated with each residue's charged group. With only a few exceptions, these charges stabilize the native state, with an average loss of 0.5 kcal/mol of stability upon neutralization of a charge. When the charge is reversed, the average destabilization is doubled. Structure-based calculations of electrostatic free energy with the continuum method based on the finite difference solution to the linearized Poisson-Boltzmann equation reproduce the observed energetics when the polarizability in the protein interior is represented with a dielectric constant of 20. However, in some cases, large differences are found, giving insight into possible areas for improvement of the calculations. In particular, it appears that the assumptions made in the calculations about the absence of electrostatic interactions in the denatured state and the energetic consequences of dynamic fluctuations in the native state will have to be further explored.
Expression and characterization of human factor IX and factor IX-factor X chimeras in mouse C127 cells. (1990)

Human blood clotting factor IX, and two chimeric molecules of factor IX, in which the first epidermal growth factor-like domain or both epidermal growth factor-like domains have been replaced by that of human factor X, have been expressed in mouse C127 cells. The recombinants have been purified using a metal ion-dependent monoclonal antibody specific for residues 1-42 of human factor IX. All recombinant molecules are activated normally by human factor XIa in the presence of calcium ion. Activation of the factor IX recombinants by factor VIIa-tissue factor appears to be normal for the epidermal growth factor-1 exchange but considerably reduced for the construction containing both epidermal growth factor-like domains of factor X. The analysis of gamma-carboxyglutamic acid residues reveals that all of the purified recombinants are almost fully carboxylated. The extent of aspartic acid hydroxylation at residue 64 is 60% for all recombinants. The chimeric molecule with both epidermal growth factor-like domains from factor X has about 4% normal activity in the activated partial thromboplastin time assay. In contrast, the construct containing the first epidermal growth factor-like domain of factor X shows essentially normal clotting activity. Thus, it is unlikely that this domain is involved in a unique interaction with factor VIII.
Light Regulation of Stomatal Movement (2007)

Stomatal pores, each surrounded by a pair of guard cells, regulate CO2 uptake and water loss from leaves. Stomatal opening is driven by the accumulation of K+ salts and sugars in guard cells, which is mediated by electrogenic proton pumps in the plasma membrane and/or metabolic activity. Opening responses are achieved by coordination of light signaling, light-energy conversion, membrane ion transport, and metabolic activity in guard cells. In this review, we focus on recent progress in blue- and red-light-dependent stomatal opening. Because the blue-light response of stomata appears to be strongly affected by red light, we discuss underlying mechanisms in the interaction between blue-light signaling and guard cell chloroplasts.
Address resolution for an intelligent filtering bridge running on a subnetted ethernet system (1987)

When a generic host goes down or moves on a subnetted configuration on Ethernets running, for example TCP/IP, and comes back up again, with either a completely new network interface, or a newly assinged protocol address, this information is not currenlty available to remote hosts/devices on the system. What I propose here is a facility whereby all connected systems can be informed of this "REBOOT" situation as soon as it is detected by its neighbouring Bridge. This way, subsequent redundant, and wasteful transmissions can be prevented taking place from remote sources to 'unobtainable' hosts. A broadcast medium such as Ethernet is assumed.
SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). (1994)

SP-303, a large proanthocyanidin oligomer isolated from the latex of the plant species Croton lechleri (Eupborbiaceae) has demonstrated broad activity against a variety of DNA and RNA viruses. In cell culture, SP-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (RSV), influenza A virus (FLU-A) and parainfluenza virus (PIV). Parallel assays of SP-303 and ribavirin showed comparable activity against these viruses. SP-303 also exhibits significant inhibitory activity against herpesvirus (HSV) types 1 and 2, including herpesviruses resistant to acyclovir and foscarnet. Inhibition was also observed against hepatitis A and B viruses. The antiviral mechanism of SP-303 seems to derive from its direct binding to components of the viral envelope, resulting in inhibition of viral attachment and penetration of the plasma membrane. Antiviral effects of SP-303 were measured by three distinct methods: CPE, MTT and precursor uptake/incorporation. Cytotoxicity endpoints were markedly greater than the respective antiviral endpoints. SP-303 exhibited activity in RSV-infected cotton rats and African green monkeys, PIV-3-infected cotton rats, HSV-2 infected mice and guinea pigs and FLU-A-infected mice. The most successful routes of SP-303 administration for producing efficacy were: topical application to HSV-2- genital lesions in mice and guinea pigs, aerosol inhalation to FLU-A-infected mice and PIV-3-infected cotton rats, and oral dosage to RSV-infected cotton rats. A variety of toxicological evaluations demonstrated the safety of SP-303, particularly orally, which was predictable, since condensed tannins are a common dietary component. It is notable that the larger proanthocyanidins as a class have high antiviral activity, whereas most of the monomers are inactive. Clinical trials are ongoing to evaluate SP-303 as a therapeutic antiviral agent.
Backside-configured surface plasmonic structure with over 40 times photocurrent enhancement (2013)

In this paper, we report a quantum dot infrared photodetector (QDIP) enhanced by a backside-configured surface plasmonic structure with an over 40 times peak photocurrent enhancement. The QDIP enhancement by the backside-configured plasmonic structure is compared with that by the top-configured plasmonic structure. The backside-configured plasmonic structure shows much higher photocurrent and photodetectivity D* enhancement. We analyze the excitation of the surface plasmonic waves by the backside-configured and top-configured plasmonic structures. The higher enhancement is attributed to the more efficient surface plasmonic excitation by the backside-configured plasmonic structure.