gebhart/patrepeval huggingface dataset:
Evaluation of Performance of the Gen-Probe Human Immunodeficiency Virus Type 1 Viral Load Assay Using Primary Subtype A, C, and D Isolates from Kenya (2000)

Accurate and sensitive quantification of human immunodeficiency virus type 1 (HIV-1) RNA has been invaluable as a marker for disease prognosis and for clinical monitoring of HIV-1 disease. The first generation of commercially available HIV-1 RNA tests were optimized to detect the predominant HIV-1 subtype found in North America and Europe, subtype B. However, these tests are frequently suboptimal in detecting HIV-1 genetic forms or subtypes found in other parts of the world. The goal of the present study was to evaluate the performance of a new viral load assay with non-subtype B viruses. A transcription-mediated amplification method for detection and quantitation of diverse HIV-1 subtypes, called the Gen-Probe HIV-1 viral load assay, is under development. In this study we examined the performance of the Gen-Probe HIV-1 viral load assay relative to that of the commonly used commercial HIV-1 RNA assays using a panel of primary isolates from Kenya. For comparison, we included several subtype B cloned viruses, and we quantified each virus using an in-house quantitative-competitive reverse transcriptase PCR (QC-RT-PCR) method and gag(p24) antigen capture. The Gen-Probe HIV-1 viral load assay and a version of the Roche AMPLICOR HIV-1 MONITOR test (version 1.5) that was designed to detect a broader range of subtypes were both sensitive for the quantification of Kenyan primary isolates, which represented subtype A, C, and D viruses. The Gen-Probe HIV-1 viral load assay was more sensitive for the majority of viruses than the Roche AMPLICOR HIV-1 MONITOR test version 1.0, the Bayer Quantiplex HIV RNA 3.0 assay, or a QC-RT-PCR method in use in our laboratory, suggesting that it provides a useful method for quantifying HIV-1 RNAs from diverse parts of the world, including Africa.
Antibiotic and Cytotoxic Activity of Brominated Compounds from the Marine Sponge Verongia aerophoba (1993)

Analysis of the marine sponge Verongia aerophoba from the Canary Islands afforded eight brominated secondary metabolites including the small molecular weight compounds aeroplysinin-1 (5) and the dienone (7) which were previously shown to arise by enzymatically catalyzed degradation of aerophobin-2 (4) and isofistularin-3 (1) following breakdown of the cellular compartmentation of the sponge. All compounds were identified from their NMR and mass spectra. Aeroplysinin-1 as well as dienone which arise from isofistularin-3 or aerophobin-2 by biotransformation within the sponge showed a significantly higher antibiotic as well as cytotoxic activity than their biogenetic precursors. Antibiotic activity was studied with respect to several gram-positive and gram-negative bacteria including B. subtilis, S. aureus and E. coli. The MICs (MBCs) of aeroplysinin-1 (5) and the dienone (7) varied between 12.5-25 (50-100) micrograms/ml respectively. Cytotoxicity was tested in vitro towards HeLa cells, a human cervix uteri tumour cell line. Aeroplysinin-1 (5) and the dienone (7) displayed pronounced cytotoxic activity with IC50s of 3.0 and 3.2 microM respectively. A five-fold increase in cytotoxicity was observed after O-acetylation of the dienone (7). The IC50 of the dienone O-acetate (0.6 microM) was comparable to that of the clinically used anticancer drug cisplatin (0.7 microM).
Flow Behavior of Foam as a Well Circulating Fluid (1972)

This paper was prepared for presentation at the 47th Annual Fall Meeting of the Society of Petroleum Engineers held in San Antonio, Tex., Oct. 8–11, 1972. Permission to copy is restricted to an abstract of not more than 300 words. Illustrations may not be copied. The abstract should contain conspicuous acknowledgment of where and by who the paper is presented. Publication elsewhere after publication in the JOURNAL paper is presented. Publication elsewhere after publication in the JOURNAL OF PETROLEUM TECHNOLOGY or the SOCIETY OF PETROLEUM ENGINEERS JOURNAL is usually granted upon request to the Editor of the appropriate journal provided agreement to give proper credit is made. provided agreement to give proper credit is made. Discussion of this paper is invited. Three copies of any discussion should be sent to the Society of Petroleum Engineers office. Such discussion may be presented at the above meeting and, with the paper, may be considered for publication in one of the two SPE magazines. Abstract Equations for steady-state flow of aqueous foam in circular pipes were formulated from laboratory and pilot-scale experimental data. pilot-scale experimental data. These equations were incorporated into a mathematical model of foam circulation in oil wells. The model was tested in two oil wells, and predictions were satisfactory for predictions were satisfactory for engineering calculations. Accuracy of the model may be increased further by accounting for liquid holdup during foam circulation in large-diameter wells. Introduction Aqueous foams have proven effective and economic as circulating fluids in well cleanout and drilling operations, and are becoming increasingly important for a wide range of oil field work. Information on the flow behavior of foam in oil wells is important for designing and conducting these foam operations. Previous work on foam rheology by David and Marsden pertained to capillary tubes only, and validity of results in oil field-size systems is not known. Mitchell measured flow characteristics of foam in tubes up to 0.1 inch in diameter. Results were used by Krug and Mitchell to develop a calculation method for circulation of foam in oil wells, but no field-scale experiments were reported to demonstrate accuracy of their predictions Work published by Wenzel et al. was for larger pipe sizes, but the foam was drier pipe sizes, but the foam was drier than that normally used in oil field applications. The foam flow equations presented herein have been tested in field-scale systems. These equations should improve the industry's ability to design and conduct oil field foam operations.
Expression of Active Human Interferon-β in Transgenic Plants (1992)

Tobacco plants were transformed with the human gene for interferon-beta (IFN-beta). Transformation was determined by the polymerase chain reaction (PCR), and expression was determined by Western blot analysis, by purifying the IFN from the transgenic plants, and by bioassays indicating its activity in human cells. Plants expressing IFN-beta were self-pollinated. IFN-beta-expressing progeny plants were selected and produced active IFN-beta, indicating stable transformation.
Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques (2016)

Combining the SENSE technique with CS (R = 2 × 2) enables considerable acceleration of CEST image acquisition and potentially has a wide range of clinical applications. Magn Reson Med 77:779-786, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
The Inhibitory Effects of Local Anesthetics on Superoxide Generation of Neutrophils Correlate with Their Partition Coefficients (1997)

Lidocaine and tetracaine suppress superoxide anion (O2-) generation of neutrophils. We examined the effects of eight local anesthetics on O2- generation in human neutrophils and searched for a potential relationship between the biological activities and the physicochemical properties of presently available eight local anesthetics. Human neutrophils incubated with local anesthetic and a Cypridina luciferin analog as a O2(-)-specific chemiluminescence probe were stimulated by phorbol ester. The chemiluminescence development based on O2- generation was monitored by a luminometer. All of the tested local anesthetics suppressed O2- generation in a concentration-dependent manner. The concentration of each of eight local anesthetics that produced 50% inhibition of peak chemiluminescence (IC50) had a rank order of dibucaine < tetracaine < bupivacaine < ropivacaine < procaine < mepivacaine < lidocaine = prilocaine. A linear relationship was obtained between IC50 values and the values of logarithm of partition coefficient (log P) of eight local anesthetics; log (IC50 in molarity) = -1.252 - 0.514 x log P, r2 = 0.891, P < 0.001. Unlike with staurosporine, which inhibits protein kinase C (PKC), no effect was observed on the O2- generation in the presence of tetrodotoxin (TTX), veratridine (VTD), or amiloride. These results suggest that the inhibitory effects of local anesthetics on O2- generation of neutrophils are predicted by physicochemical properties of the drugs, especially partition coefficients.
Behavioral synthesis methodology for HDL-based specification and validation (1995)

This paper describes a HDL synthesis based design methodology that supports user adoption of behavioral-level synthesis into normal design practices. The use of these techniques increases understanding of the HDL descriptions before synthesis, and makes the comparison of pre-and post-synthesis design behavior through simulation much more direct. This increases user confidence that the specification does what the user wants, i.e. that the synthesized design matches the specification in the ways that are important to the user. At the same time, the methodology gives the user a powerful set of tools to specify complex interface timing, while preserving a user's ability to delegate decision-making authority to software in those cases where the user does not wish to restrict the options available to the synthesis algorithms.
Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene (1984)

We investigated whether the addition of d-limonene to the diets of rats would modify the process of mammary tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA). When diets containing 1000 or 10 000 p.p.m. d-limonene were fed to rats from one week before DMBA administration to the end of the experiment (27 weeks post DMBA treatment), a significant reduction in mammary carcinogenesis was observed at each level. The inhibition of carcinogenesis was mainly due to an increase in latency; however, major differences in incidence could be seen during the follow-up period. For example, rats fed 10 000 p.p.m. of d-limonene had a 72% reduction in mammary tumors when compared to controls at 18 weeks post DMBA treatment. In addition to inhibiting the appearance of mammary tumors, d-limonene was also found to cause the regression of frank mammary tumors. No toxicity was evident in these rats even at the highest d-limonene dose. Control and all treated rats gained weight at the same rate throughout the experiment. In addition, no differences were found in their peripheral blood counts (Hct, total white cell and differential count).
Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. (1995)

The c-MET oncogene encodes the receptor for hepatocyte growth factor (HGF) scatter factor, a multifunctional cytokine able to mediate morphogenesis as well as invasive growth of epithelial cells. The c-MET-encoded receptor is detectable only at low levels in the normal human exocrine pancreas, but it is up-regulated in the majority of pancreatic ductal adenocarcinomas. The c-MET-encoded HGF receptor is also overexpressed in a proportion of the panel of 31 human pancreatic cancer cell lines examined, which have a range of different growth properties and degrees of differentiation. In most cases the HGF receptor found in the malignant cells has features of the normal receptor. When added to pancreatic cancer cell lines, HGF triggers receptor phosphorylation and stimulates cells to move and proliferate. In overexpressing cell lines, the Met/HGF receptor is phosphorylated in the absence of endogenously produced or exogenously added ligand. These data suggest that the Met/HGF receptor may be involved in the growth and behavior of pancreatic cancer and may contribute to the ductal phenotype of these tumors.
Solving SAT and SAT Modulo Theories (2006)

We first introduce Abstract DPLL , a rule-based formulation of the Davis--Putnam--Logemann--Loveland (DPLL) procedure for propositional satisfiability. This abstract framework allows one to cleanly express practical DPLL algorithms and to formally reason about them in a simple way. Its properties, such as soundness, completeness or termination, immediately carry over to the modern DPLL implementations with features such as backjumping or clause learning.We then extend the framework to Satisfiability Modulo background Theories (SMT) and use it to model several variants of the so-called lazy approach for SMT. In particular, we use it to introduce a few variants of a new, efficient and modular approach for SMT based on a general DPLL( X ) engine, whose parameter X can be instantiated with a specialized solver Solver T for a given theory T , thus producing a DPLL( T ) system. We describe the high-level design of DPLL( X ) and its cooperation with Solver T , discuss the role of theory propagation , and describe different DPLL( T ) strategies for some theories arising in industrial applications.Our extensive experimental evidence, summarized in this article, shows that DPLL( T ) systems can significantly outperform the other state-of-the-art tools, frequently even in orders of magnitude, and have better scaling properties.
Efficient Word Retrieval Using a Multiple Ranking Combination Scheme (2012)

Word retrieval is an important task in the area of document analysis and recognition. The selection of appropriate features is a crucial step in the word matching and retrieval process. Several efficient techniques have been proposed which use a wide range of features. This paper proposes a methodology for the efficient fusion of multiple ranking results produced by different word matching techniques. Specifically, a Minimum Ranking method is proposed for the combination of two or more ranking results. The method is compared with two state-of-the-art ranking fusion methods. The experimental results show that the fusion of the ranked results outperforms the ranking efficiency of the individual systems. Moreover, the proposed Minimum Ranking method outperforms the other two state-of-the-art fusion methods.
Antacid vs Sucralfate in Preventing Acute Gastrointestinal Tract Bleeding in Abdominal Aortic Surgery (1986)

We carried out a randomized, controlled trial of sucralfate vs antacid as prophylaxis against upper gastrointestinal tract bleeding in 50 patients who had undergone abdominal aortic surgery. The groups were similar in age, sex, duration of prophylaxis, and number of risk factors per patient. No patient in the antacid group had upper gastrointestinal tract bleeding. One patient in the sucralfate group had frank bleeding from the nasogastric tube; however, she also had a coagulopathy and thrombocytopenia. The bleeding stopped when these conditions were corrected. No complications occurred in the sucralfate group; five patients in the antacid group had minor complications. Sucralfate was as effective as antacid in this trial, and it resulted in a considerable saving in nursing time.
Encoding Molecular‐Wire Formation within Nanoscale Sockets (2007)

Wire straits: Three-component molecular wires were constructed in situ by first assembling a monolayer of a bifunctional arene on the electrode surfaces, such that only one end of the molecule (thiol) reacts with the electrode. Then, a second molecule was used to chemically bridge the gap between the termini of the films. Coordination chemistry in this context provides a versatile method to reversibly form molecular-scale wires (see picture). EDTA=ethylenediaminetetraacetate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604398_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Reactivity of Rat Pial Arterioles and Venules to Adenosine and Carbon Dioxide: With Detailed Description of the Closed Cranial Window Technique in Rats (1986)

This study describes a closed cranial window technique that allows the observation and measurement of rat pial arterioles and venules in situ. The resolving power of this system is 1-2 microns. Using this sensitive technique, we characterized the responses to 7% carbon dioxide inhalation and adenosine in arterioles (10-70 microns) and venules (15-100 microns). During carbon dioxide inhalation, larger arterioles (greater than 40 microns) dilated more than smaller arterioles (less than 20 microns). There was limited vasoreactivity of pial venules during CO2 inhalation. Dilation of arterioles was initially observed with an adenosine concentration of 10(-8) M. Almost a twofold increase in diameter was noted at 10(-3) M. In contrast to the effect of CO2 inhalation, the degree of dilation with topical application of adenosine was not size dependent. Pial venules did not respond to adenosine. The technique for observation of pial vessels using the closed cranial window and for measurement of vessel diameter by video camera system microscopy is a powerful tool for studying in vivo the cerebral circulation in the rat.
A 12-Month Phase 3 Study of Pasireotide in Cushing's Disease (2012)

The significant decrease in cortisol levels in patients with Cushing's disease who received pasireotide supports its potential use as a targeted treatment for corticotropin-secreting pituitary adenomas. (Funded by Novartis Pharma; ClinicalTrials.gov number, NCT00434148.).
Pulmonary bacterial coinfection in infants and children with viral respiratory infection (2012)

The true incidence of pulmonary bacterial coinfection in infants and children hospitalized with a viral respiratory infection is difficult to ascertain but can vary widely from under 1 to 44%. For the same patient group admitted to pediatric intensive care units and/or requiring ventilatory support, the evidence is more convincing, with reported incidences of 17-39%. Studies covering influenza and respiratory syncytial virus infection dominate the recent literature. Whether treatment (or 'cover') with antibiotics is indicated/justified lies in the balance of risk of pulmonary bacterial coinfection (or risk of not diagnosing it), severity of disease and the patient setting. The balance between the overprescription of antibiotics and the possible sequelae associated with bacterial coinfection in infants and children continues to fuel debate.
Poisson Sphere Distributions (2006)

We present a method for efficiently generating Poisson sphere distributions, the three-dimensional equivalent of Poisson disk distributions. Our method is able to generate arbitrarily large Poisson sphere distributions in real time, and allows local evaluation of the generated distributions. The method we present is based on cubes with colored corners, called corner cubes, an extension of corner tiles. We generalize tiling algorithms and construction methods from corner tiles to corner cubes. Poisson sphere distributions have several useful applications in computer graphics, such as geometry instancing and a three-dimensional procedural object distribution function.
Nanotube Formation through the Continuous One-Dimensional Fusion of Hollow Nanocapsules Composed of Layer-by-Layer Poly(lactic acid) Stereocomplex Films (2010)

Hollow nanocapsules composed of a poly(lactic acid)s (PLAs) stereocomplex can be fabricated by a combination of the layer-by-layer assembly technique and the silica template method. These hollow capsules one-dimensionally fuse together to generate novel PLA nanotubes. The formation of nanotubes was affected by the molecular weights of PLAs constituting the hollow capsules.
Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway (2007)

A humanized anti-HER2 monoclonal antibody pertuzumab (Omnitarg, 2C4), binding to a different HER2 epitope than trastuzumab, is known as an inhibitor of heterodimerization of the HER receptors. Potent antitumor activity against HER2-expressing breast and prostate cancer cell lines has been clarified, but this potential is not clear against lung cancers. The authors investigated the in vitro anti-tumor activity of pertuzumab against eight non-small cell lung cancer cells expressing various members of the HER receptors. A lung cancer 11_18 cell line expressed a large amount of HER2 and HER3, and its cell growth was stimulated by an HER3 ligand, heregulin (HRG)-alpha. Pertuzumab significantly inhibited the HRG-alpha-stimulated cellular growth of the 11_18 cells. Pertuzumab blocked HRG-alpha-stimulated phosphorylation of HER3, mitogen-activated protein kinase (MAPK), and Akt. In contrast, pertuzumab failed to block epidermal growth factor (EGF)-stimulated phosphorylation of EGF receptor (EGFR) and MAPK. Immunoprecipitation showed that pertuzumab inhibited HRG-alpha-stimulated HER2/HER3 heterodimer formation. HRG-alpha-stimulated HER3 phosphorylation was also observed in the PC-9 cells co-overexpressing EGFR, HER2, and HER3, but the cell growth was neither stimulated by HRG-alpha nor inhibited by pertuzumab. The present results suggest that pertuzumab is effective against HRG-alpha-dependent cell growth in lung cancer cells through inhibition of HRG-alpha-stimulated HER2/HER3 signaling.
Isometric Lifting Strength As a Predictor of Industrial Back Pain Reports (1989)

The objective of our investigation was to study isometric lifting strength in a population of industrial workers who perform a great variety of manual tasks, and to determine whether isometric strength is predictive of future back problems in such a population. Of 3,020 study subjects, 2,178 (72%) underwent strength testing in three standard lifting positions. During a 4-year follow-up period, 172 subjects tested reported back problems. When examining each isometric lift separately as a predictor of industrial back pain reports, those with greater isometric strength were at significantly greater risk than were weaker workers. However, after controlling for the effects of age, only a slight trend remained. For the blue collar workers in this study, isometric lifting strength testing was ineffective in identifying individuals at risk for industrial back problems.
MODULATION OF CARDIAC ION CHANNELS BY MAGNESIUM (1991)

In large part stimulated by recent advances in the measurement of cytosolic magnesium activity, there has been a surge of interest in the effects of this ion on cardiac channel function. Studies have demonstrated potentially important effects on calcium channels and potassium channels that may have significant consequences on action potential duration and cell excitability. Here, we will briefly review the extracellular and intracellular effects of magnesium on the ionic currents in cardiac myocytes.
Sulfoximines: Synthesis and Catalytic Applications (2004)

Abstract Chiral sulfoximines have a stereogenic center at the sulfur atom and their use in asymmetric synthesis is well established. Recently, sulfoximines have been recognized as an interesting new class of chiral ligands, which can be applied in various asymmetric metal catalyses. This review summarizes the latest progress in synthetic methods towards sulfoximines and the application of chiral derivatives in catalytic asymmetric reactions.