gebhart/patrepeval huggingface dataset:
Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma (2006)

We conclude that the up-regulation of AURKA mRNA may play a critical role in the tumor progression of HNSCC and provides useful information as a prognostic factor for HNSCC patients.
One‐compound‐multiple‐targets strategy to combat Alzheimer's disease (2005)

The present one-drug-one-target paradigm in drug discovery has been considered partially responsible for the more-funding-less-drug predicament in modern pharmaceutical industry. To hit the multiple targets implicated in complex diseases, two strategies, based on multicomponent or single-ingredient, are conceivable. Although the latter is more difficult to be fulfilled than the former, the recent progress made in the fight against Alzheimer's disease (AD) has brought us the first light of success of the latter strategy. In this review, both synthetic and natural multipotent agents are described, which hit two or more targets implicated in AD, e.g., acetylcholinesterase, monoamine oxidase, amyloid-beta, tau protein, metal ions and reactive oxygen species. Nevertheless, due to the potential risks in safety, absorbability and pharmacokinetics of synthetic multipotent agents, natural counterparts seem more promising in the future development.
Osteoactivin Promotes Breast Cancer Metastasis to Bone (2007)

The skeleton is a preferred site of metastasis in patients with disseminated breast cancer. We have used 4T1 mouse mammary carcinoma cells, which metastasize to bone from the mammary fat pads of immunocompetent mice, to identify novel genes involved in this process. In vivo selection of parental cells resulted in the isolation of independent, aggressively bone metastatic breast cancer populations with reduced metastasis to the lung. Gene expression profiling identified osteoactivin as a candidate that is highly and selectively expressed in aggressively bone metastatic breast cancer cells. These cells displayed enhanced migratory and invasive characteristics in vitro, the latter requiring sustained osteoactivin expression. Osteoactivin depletion in these cells, by small interfering RNA, also lead to a loss of matrix metalloproteinase-3 expression, whereas forced osteoactivin expression in parental 4T1 cells was sufficient to elevate matrix metalloproteinase-3 levels, suggesting that this matrix metalloproteinase may be an important mediator of osteoactivin function. Overexpression of osteoactivin in an independent, weakly bone metastatic breast cancer cell model significantly enhanced the formation of osteolytic bone metastases in vivo. Finally, high levels of osteoactivin expression in primary human breast cancers correlate with estrogen receptor-negative status and increasing tumor grade. Thus, we have identified osteoactivin as a protein that is expressed in aggressive human breast cancers and is capable of promoting breast cancer metastasis to bone.
A clinical evaluation of tazarotene 0.1% gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis (2002)

Some steroids are considerably more effective than others in optimizing the efficacy and tolerability of tazarotene therapy. With a suitable combination regimen, the duration of initial therapy (before maintenance therapy is started) need not be prolonged.
Deep Residual Learning for Compressed Sensing CT Reconstruction via Persistent Homology Analysis (2016)

Recently, compressed sensing (CS) computed tomography (CT) using sparse projection views has been extensively investigated to reduce the potential risk of radiation to patient. However, due to the insufficient number of projection views, an analytic reconstruction approach results in severe streaking artifacts and CS-based iterative approach is computationally very expensive. To address this issue, here we propose a novel deep residual learning approach for sparse view CT reconstruction. Specifically, based on a novel persistent homology analysis showing that the manifold of streaking artifacts is topologically simpler than original ones, a deep residual learning architecture that estimates the streaking artifacts is developed. Once a streaking artifact image is estimated, an artifact-free image can be obtained by subtracting the streaking artifacts from the input image. Using extensive experiments with real patient data set, we confirm that the proposed residual learning provides significantly better image reconstruction performance with several orders of magnitude faster computational speed.
Dynamics of Transcription and Pre-mRNA Splicing within the Mammalian Cell Nucleus (1993)

Splicing is an essential step in the processing of intron-containing pre-mRNAs prior to their transport out of the nucleus (for review, see Green 1991). During the last few years, a significant number of studies have addressed the relationship of pre-mRNA splicing to nuclear structure (for review, see Spector 1993). SnRNPs as well as several non-snRNP splicing factors have been shown by immunofluorescence microscopy to be localized in a speckled pattern that is distributed in various regions throughout the nucleoplasm. Poly(A)+ RNA has been shown to colocalize with these nuclear speckles (Carter et al. 1991, 1993). Several specific RNAs have been localized in association with, the periphery of one or more speckles in a particular cell nucleus (Huang and Spector 1991; Xing et al. 1993). At the electron microscopic level, the speckled pattern corresponds to interchromatin granule clusters and perichromatin fibrils (Perraud et al. 1979; Fakan et al. 1984; Puvion et...
Triacylglycerol Biosynthesis in Human Small Intestinal Mucosa. Acyl-CoA: Monoglyceride Acyltransferase (1983)

Acyl-CoA: monoglyceride acyltransferase (MGAT; EC 2.3.1.22) has been studied in human small intestinal mucosa by means of a spectrophotometric method based on the detection of liberated CoA employing 5,5'-dithiobis-(2-nitrobenzoic acid). With optimal assay conditions available the pH optimum was spread between 7.0 and 7.7 with a maximum at a pH of 7.4. Dependent on its concentration one of the substrates, palmitoyl-CoA, caused severe inhibition which was largely prevented by the addition of albumin. Using palmitoyl-CoA and 1-monooleoylglycerol as substrates specific activities were 23.0 +/- 8.4 in total homogenates compared with 92.9 +/- 28.3 nmol CoA released/min/mg protein in microsomal fractions from jejunal mucosa. Concerning the substrate specificity, a broad acyl-donor pattern exists with maximal activities for C10:0 to C16:0, the highest for C16:0. A preferential esterification of acyl-acceptors was shown for 2-monoacylglycerols as compared with the 1-isomers, and for monoacylglycerols with unsaturated versus saturated fatty acids. MGAT was mainly localized in the microsomal fraction. The properties of MGAT from human small intestine are discussed with respect to the intestinal enzyme from other species.
Fabrication and characterization of microfibrillated cellulose and collagen composite films (1996)

Microfibrillated cellulose (MFC)-collagen composite films were prepared with a dispersion of acid swollen collagen fibers and carboxylated MFC at different ratios in an alkaline homogenous system. The surface topographic results obtained from SEM analyses indicated that the MFC entangled uniformly with collagen in the film and formed a closely interwoven network to reinforce the film structure. However, the MFC addition decreased the smoothness and light transparency of the films due to the aggregation of MFC. Compared to the film prepared with pure collagen, the hybrid composite film showed a higher strength and Young's modulus but lower elongation. The swelling of the composite film in water increased with the increase of the MFC ratio in the film matrix. DSC and TG analyses demonstrated that adding MFC to collagen benefited the thermal stability of the films, due to the conformational and crystal changes in the MFC/collagen structure indicated by the FT-IR and XRD results. The MFC/collagen composite film can potentially be used as an edible material in the food and packaging industry, in particular for meat products.
An Ulster 2C strain‐derived Newcastle disease vaccine: Vaccinal reaction in comparison with other lentogenic Newcastle disease vaccines (1991)

Vaccinal reaction and seroresponse induced by an Ulster 2C strain derived Newcastle disease (ND) vaccine (ND) (PoulvacR NDW Broiler) were compared with those due to three other lentogenic ND vaccines (NDP, LZ58 and Clone 30) used in broilers in the Netherlands. Comparisons were made in SPF-WL hens and commercial broilers with maternally derived antibodies, using a fully standardized model. The criteria used were body weight gain and mortality rate following vaccine aerosol exposure and susceptibility to experimentally induced Colibacillosis. The NDW vaccine was the mildest, followed by Clone 30-, LZ58- and NDP vaccine. Although the seroresponse of SPF-WL hens exposed to NDW vaccine was significantly less than that induced by the other vaccines, the response was still substantial. Seroresponse to NDP-, LZ58- and Clone 30 vaccine did not differ significantly mutually. In broilers, serores-ponses to NDW- and Clone 30-vaccine were similar.
Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters (2016)

Blood Phe concentrations affected peripheral monoamine neurotransmitter biomarker concentrations differently in each individual with PKU. Melatonin levels increased with BH4 therapy only when blood Phe decreased. Monitoring peripheral neurotransmitter metabolites may assist in optimizing individualized treatment in PKU.
Field ion emission (1990)

Field ion images are formed by field ionization. Without this process there would simply be no field ion microscope. Field ionization is therefore the most important physical process in field ion microscopy. Theories of field ionization actually preceded field ion microscopy by over twenty years. In 1928, when quantum mechanics was still in its infancy, Oppenheimer found by detailed quantum mechanical calculations that under a field of about 2 V/Å the electron in a hydrogen atom could tunnel out of the atom into the vacuum. This is one of the earliest theories of quantum mechanical tunneling phenomena. In the same year Fowler & Nordheim used the quantum mechanical tunneling effect to explain field emission phenomena, and Gamow, Gurney and Condon also explained α-particle decay by tunneling of helium nucleus out of a heavy nucleus. These theories represented early triumphs of quantum mechanics outside of atomic systems. Tunneling from excited states of hydrogen atoms was treated by Lanczos to explain field induced quenching of spectral lines in Stark effect at a field near 106 V/cm, the highest attainable in gaseous discharge tubes. Gurney considered inverse tunneling in the much higher fields that were encountered in the cathodic neutralization of H+ ion in an electrolyte, and was already discussing how the atomic level would line up with the electronic levels, including the Fermi level, of the electrode at different distances. Although these studies were probably known to some of the early pioneers in field ion microscopy, there is no evidence that they directly influenced the early development of the field ion microscope.
Common DNS Data File Configuration Errors (1993)

This memo describes errors often found in DNS data files.It points out common mistakes system administrators tend to make and why they often go unnoticed for long periods of time.
Peptidoglycan recognition in innate immunity (2005)

The innate immune system recognizes micro-organisms through a series of pattern recognition receptors that are highly conserved in evolution. Peptidoglycan (PGN) is a unique and essential component of the cell wall of virtually all bacteria, is not present in eukaryotes, and is an excellent target for the innate immune system. Indeed, higher eukaryotes, including mammals, have several PGN recognition molecules, including CD14, Toll-like receptor 2 (TLR2), nucleotide oligomerization domain (Nod)-containing proteins, a family of peptidoglycan recognition proteins (PGRPs), and PGN-lytic enzymes (lysozyme and amidase). These molecules induce host responses to micro-organisms, degrade PGN, or have direct antimicrobial effects.
Isatin-derived Antibacterial and Antifungal Compounds and their Transition Metal Complexes (2004)

A series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, IR, NMR and electronic spectral data. These compounds have been screened for antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the synthesized compounds have shown good affinity as antibacterial and/or antifungal agents which increased in most of the cases on complexation with the metal ions.
杰克·伦敦——冒险的呼唤 (2008)

美国作家杰克·伦敦幼时家境贫寒,以卖苦力为生。苦难的生活没有将他击倒,反而磨练出他顽强进取的精神。自小就喜欢阅读探险类书籍和冒险故事的杰克·伦敦结合自己的冒险经历创作出了50多部作品,在现代美国文学和世界文学中享有崇高的地位。
Nonribosomal Peptide Synthase Gene Clusters for Lipopeptide Biosynthesis in Bacillus subtilis 916 and Their Phenotypic Functions (2014)

Bacillus cyclic lipopeptides (LPs) have been well studied for their phytopathogen-antagonistic activities. Recently, research has shown that these LPs also contribute to the phenotypic features of Bacillus strains, such as hemolytic activity, swarming motility, biofilm formation, and colony morphology. Bacillus subtilis 916 not only coproduces the three families of well-known LPs, i.e., surfactins, bacillomycin Ls (iturin family), and fengycins, but also produces a new family of LP called locillomycins. The genome of B. subtilis 916 contains four nonribosomal peptide synthase (NRPS) gene clusters, srf, bmy, fen, and loc, which are responsible for the biosynthesis of surfactins, bacillomycin Ls, fengycins, and locillomycins, respectively. By studying B. subtilis 916 mutants lacking production of one, two, or three LPs, we attempted to unveil the connections between LPs and phenotypic features. We demonstrated that bacillomycin Ls and fengycins contribute mainly to antifungal activity. Although surfactins have weak antifungal activity in vitro, the strain mutated in srfAA had significantly decreased antifungal activity. This may be due to the impaired productions of fengycins and bacillomycin Ls. We also found that the disruption of any LP gene cluster other than fen resulted in a change in colony morphology. While surfactins and bacillomycin Ls play very important roles in hemolytic activity, swarming motility, and biofilm formation, the fengycins and locillomycins had little influence on these phenotypic features. In conclusion, B. subtilis 916 coproduces four families of LPs which contribute to the phenotypic features of B. subtilis 916 in an intricate way.
Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model (2008)

The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation-contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterogeneous electromechanical behaviour in these cells. The simulations (i) illustrate a previously unrecognized role of the transient outward potassium current in mechanical function and (ii) suggest that there may also exist additional heterogeneities affecting crossbridge cycling rates in cells from different transmural regions.
Digital color halftoning with generalized error diffusion and multichannel green-noise masks (2000)

In this paper, we introduce two novel techniques for digital color halftoning with green-noise--stochastic dither patterns generated by homogeneously distributing minority pixel clusters. The first technique employs error diffusion with output-dependent feedback where, unlike monochrome image halftoning, an interference term is added such that the overlapping of pixels of different colors can be regulated for increased color control. The second technique uses a green-noise mask, a dither array designed to create green-noise halftone patterns, which has been constructed to also regulate the overlapping of different colored pixels. As is the case with monochrome image halftoning, both techniques are tunable, allowing for large clusters in printers with high dot-gain characteristics, and small clusters in printers with low dot-gain characteristics.
PRAME Gene Expression in Childhood Acute Lymphoblastic Leukemia: Impact on Prognosis (2013)

Our results suggested that PRAME was a predictor for better outcome, could be a useful target for immunotherapy, and might represent a candidate marker for the monitoring of minimal residual disease.
Prospective Use of Ultrasound Imaging to Detect Bony Hand Injuries in Adults (2007)

Ultrasound imaging performed by emergency sonologists showed excellent sensitivity and specificity in the diagnosis of hand fractures.
VACCINES, 3rd Edition (1999)

Plotkin, Stanley A. MD; Orenstein, Walter A. MD; Bernstein, David I. MD Author Information
Environmental Regulation and Differential Production of Members of the Bdr Protein Family of Borrelia burgdorferi (2002)

Borrelia burgdorferi B31MI carries 18 plasmid-carried genes that form the bdr gene family. The bdr genes of B. burgdorferi encode proteins that form three distinct subfamilies, the BdrD, BdrE, and BdrF subfamilies. bdr orthologs have been demonstrated to be carried by all Borrelia species analyzed, and their widespread distribution suggests that they play an important genus-wide functional role. The biological rationale for maintaining 18 bdr alleles has not been defined. It is our hypothesis that specific paralogs function in different environments and are differentially expressed in response to environmental conditions. As a first step in testing this hypothesis, the production patterns of the Bdr proteins in spirochetes grown under a variety of conditions were assessed through immunoblot analyses. The influence of temperature, serum deprivation, tick feeding, and the mammalian environment on Bdr production was evaluated. These analyses revealed that the synthesis of some Bdr paralogs is environmentally regulated. The production of BdrF(2,) BdrF(1), BdrE(4), and BdrE(5) were upregulated in host-adapted bacteria, while the production levels of other Bdr paralogs were influenced by temperature and serum starvation. These observations suggest that different Bdr paralogs function in different biological environments and provide insight into the biological basis for maintaining multiple members of this gene family.
Antibacterial Activity and Inhibition of Protein Synthesis in Escherichia coli by Antisense DNA Analogs (1991)

Protein synthesis, which takes place within ribosomes, is essential for the survival of any living organism. Ribosomes are composed of both proteins and RNA. Specific interaction between the 3' end CCUCC sequence of prokaryotic 16S rRNA and a partially complementary sequence preceding the initiating codon of mRNA is believed to be a prerequisite for initiation of protein synthesis. Here we report the use of short (three to six nucleotides) synthetic DNA analogs complementary to this sequence to block protein synthesis in vitro and in vivo in Escherichia coli. In the DNA analogs the normal phosphodiester bond in the antisense DNA was replaced by methylcarbamate internucleoside linkages to enhance transport across plasma membranes. Of the analogs tested, those with the sequence AGG and GGA inhibit protein synthesis and colony formation by E. coli strains lacking an outer cell wall. Polyethylene glycol 1000 (PEG 1000) was attached to the 5' end of some of the test methylcarbamate DNAs to enhance solubility. Analogs of AGG and GGAG with PEG 1000 attached inhibited colony formation in normal E. coli. These analogs may be useful food additives to control bacterial spoilage and biomedically as antibiotics.
Noninvasive Gene Expression Testing in Amelanotic Melanoma (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Assessment of the Spatial Co-registration of Multitemporal Imagery from Large Format Digital Cameras in the Context of Detailed Change Detection (2008)

Large format digital camera (LFDC) systems are becoming more broadly available and regularly collect image data over large areas. Spectral and radiometric attributes of imagery from LFDC systems make this type of image data appropriate for semi-automated change detection. However, achieving accurate spatial co-registration between multitemporal image sets is necessary for semi-automated change detection. This study investigates the accuracy of co-registration between multitemporal image sets acquired using the Leica Geosystems ADS40, Intergraph Z/I Imaging® DMC, and Vexcel UltraCam-D sensors in areas of gentle, moderate, and extreme terrain relief. Custom image sets were collected and orthorectified by imagery vendors, with guidance from the authors. Results indicate that imagery acquired by vendors operating LFDC systems may be coregistered with pixel or sub-pixel level accuracy, even for environments with high terrain relief. Specific image acquisition and processing procedures facilitating this level of coregistration are discussed.
Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia. (1997)

We conclude that PSC-MITO-VP is a tolerable regimen with antileukemic activity. Addition of PSC necessitated a 66% reduction in MITO and VP doses from a prior study without PSC.