gebhart/patrepeval huggingface dataset:
Perspectives on Brain Tumor Formation Involving Macrophages, Glia, and Neural Stem (2001)

The incidence of brain tumors is rising in children and the elderly, but little is known about the mechanisms underlying brain tumor initiation and progression. In the 1940s, Zimmerman and coworkers exploited the tumor-promoting potential of polycyclic hydrocarbons to produce brain tumor models in adult mice that simulated the neuropathology of human brain tumors. Based on these early findings and on recent neurobiological studies of stem cells, I propose that crystalline carcinogenic pellets surgically implanted in the central nervous system establish over time a microenvironment that fosters proliferation and genetic damage in neural stem cells and their progenitors. Moreover, activated glia (microglia and astrocytes) and recruited macrophages mediate these processes. Gradually local tissue fields, which normally restrict stem cell proliferation, become disorganized, leading to further stem cell proliferation, genetic damage, and eventual neoplasia. Depending on age, location, and the state of glial/macrophage activation, the resulting brain tumor may resemble transformed neural progenitors aborted in more or less differentiated states. This hypothesis integrates the general mechanisms by which neural stem cells, glia, and macrophages orchestrate the initiation and progression of brain cancer. Also discussed are implications of these concepts for the diagnosis and therapy of human brain tumors.
Essentials of Local Anesthetic Pharmacology (2006)

It is impossible to provide effective dental care without the use of local anesthetics. This drug class has an impressive history of safety and efficacy, but all local anesthetics have the potential to produce significant toxicity if used carelessly. The purpose of this review is to update the practitioner on issues regarding the basic pharmacology and clinical use of local anesthetic formulations.
Pulmonary Diseases and Disorders. (1988)

The major treatise of lung medicine is revised throughout for diagnosis and management of all pulmonary and related care disorders encountered in the critical care setting.
Coulometry with the carbon black electrode (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoulometry with the carbon black electrodeJohn D. Voorhies and Stanley M. DavisCite this: Anal. Chem. 1960, 32, 13, 1855–1857Publication Date (Print):December 1, 1960Publication History Published online1 May 2002Published inissue 1 December 1960https://pubs.acs.org/doi/10.1021/ac50153a042https://doi.org/10.1021/ac50153a042research-articleACS PublicationsRequest reuse permissionsArticle Views57Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Outcomes and Alternative Cultures of Case Management (2003)

The four different types of case management cultures such as problem-centred, enabling, recipient-centred and person-driven are likely to have profound implications for outcomes, their conceptualisation, selection, measurement and use. The actual culture of a particular case management program might be formed by the relative weight members give to each of these four cultures.
2D measurement and spatio-temporal coupling of few-cycle THz pulses (1999)

The propagation of few-cycle THz pulses are measured by the improved CCD based 2D THz imaging system. There exists strong spatio-temporal shaping effect, leading to dramatically time dependent beam diameter and wave front. Theoretical simulation is given.
VEGF inhibition and metastasis: Possible implications for antiangiogenic therapy (2009)

Since the 2004 approval of bevacizumab, a humanized monoclonal antibody that binds vascular endothelial growth factor (VEGF), antiangiogenic therapy has been used to treat selected cancers, including colon, non-small cell lung, and breast cancers. In addition to bevacizumab, the FDA has approved two other antiangiogenic therapies; sorafenib and sunitinib, both of which are tyrosine kinase inhibitors that target VEGF receptors, particularly VEGFR2. However, even with the approval of these three drugs, antiangiogenic therapy has not yet had the impact some have hoped for. Many clinical benefits are short-lived; while numerous trials have shown an increase in survival in patients treated with antiangiogenic therapy, the increase for many was a matter of months.1 While any improvement in overall survival should be regarded as an accomplishment, it is important to understand why such clinical improvements are sometimes fleeting so that newer therapies can result in more enduring benefits.
Automated Selection of Materialized Views and Indexes in SQL Databases (2000)

Automatically selecting an appropriate set of materialized views and indexes for SQL databases is a non-trivial task. A judicious choice must be cost-driven and influenced by the workload experienced by the system. Although there has been work in materialized view selection in the context of multidimensional (OLAP) databases, no past work has looked at the problem of building an industry-strength tool for automated selection of materialized views and indexes for SQL workloads. In this paper, we present an end-to-end solution to the problem of selecting materialized views and indexes. We describe results of extensive experimental evaluation that demonstrate the effectiveness of our techniques. Our solution is implemented as part of a tuning wizard that ships with Microsoft SQL Server 2000. 1.
Micropatterned Surfaces for Reducing the Risk of Catheter-Associated Urinary Tract Infection: An In Vitro Study on the Effect of Sharklet Micropatterned Surfaces to Inhibit Bacterial Colonization and Migration of Uropathogenic Escherichia coli (2011)

The Sharklet micropattern is effective at inhibiting colonization and migration of a common uropathogen. This performance is achieved through a physical surface modification without the use of any antimicrobial agents. Because deterrence of bacterial colonization and migration is a critical step to prevent CAUTI, the Sharklet micropattern offers a novel concept in addressing this important problem.
Hyaluronidases - a group of neglected enzymes (1995)

Hyaluronan is an important constituent of the extracellular matrix. This polysaccharide can be hydrolyzed by various hyaluronidases that are widely distributed in nature. The structure of some bacterial and animal enzymes of this type has recently been elucidated. It could be shown that the hyaluronidases from bee and hornet venom and the PH-20 hyaluronidase present on mammalian spermatozoa are homologous proteins.
Chemoreception of oviposition inhibiting terpenoids in the diamondback moth Plutella xylostella (1998)

Abstract The effects of six terpenoids and two terpenoid containing extracts of the neem tree ( Azadirachta indica A. Juss.) on oviposition by the diamondback moth ( Plutella xylostella L., Yponomeutidae: Lepidoptera) were tested. Two drimane terpenoids, the sesquiterpenoid polygodial and the neem extract Margosan‐O exerted significant inhibitory effects at the dosages tested. Ablation experiments showed that both antennae and fore‐tarsi contributed to mediation of the inhibition by a drimane. Location of chemosensilla on prothoracic tarsi and ovipositor was examined by scanning electronmicroscopy. Electrophysiological recordings from ovipositor and tarsal taste sensilla showed that distilled water produced distinct responses from one neuron. In tarsal sensilla, ethanol and drimane solutions produced responses from two neurons, one of which might be the water cell that fired at a reduced rate. A drimane significantly decreased the responses of tarsal chemoreceptors to a cabbage leaf extract, which is a possible sensory mechanism leading to behavioural avoidance of this compound.
Delay diversity codes for frequency selective channels (2003)

Space-time coding for the flat fading, quasi-static MIMO wireless channel has received widespread attention. This paper treats space-time code design for frequency selective channels from a single carrier modulation perspective. We present a general framework for analyzing space-time codes for delay spread channels based on PEP analysis. It is shown that as in the flat fading case, diversity gain is driven by the minimum rank of the pairwise codeword difference matrices. Delay spread, however, imposes a block Hankel structure on the codewords which may prevent certain codes designed for the flat fading case from exploiting full spatio-temporal diversity when used over frequency selective channels. We explicitly show this diversity loss for the delay diversity code. We show that a properly generalized delay diversity (GDD) code achieves full diversity over frequency selective channels. Finally we propose an extension to the GDD which fits naturally in a multi-carrier setting.
Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway (2018)

Neurofibromatosis type 1 (NF1) is a cancer predisposition disorder that results from inactivation of the tumor suppressor neurofibromin, a negative regulator of RAS signaling. Patients with NF1 present with a wide range of clinical manifestations, and the tumor with highest prevalence is cutaneous neurofibroma (cNF). Most patients harboring cNF suffer greatly from the burden of those tumors, which have no effective medical treatment. Ironically, none of the numerous NF1 mouse models developed so far recapitulate cNF. Here, we discovered that HOXB7 serves as a lineage marker to trace the developmental origin of cNF neoplastic cells. Ablating <i>Nf1</i> in the HOXB7 lineage faithfully recapitulates both human cutaneous and plexiform neurofibroma. In addition, we discovered that modulation of the Hippo pathway acts as a "modifier" for neurofibroma tumorigenesis. This mouse model opens the doors for deciphering the evolution of cNF to identify effective therapies, where none exist today. SIGNIFICANCE: This study provides insights into the developmental origin of cNF, the most common tumor in NF1, and generates the first mouse model that faithfully recapitulates both human cutaneous and plexiform neurofibroma. The study also demonstrates that the Hippo pathway can modify neurofibromagenesis, suggesting that dampening the Hippo pathway could be an attractive therapeutic target.<i>This article is highlighted in the In This Issue feature, p. 1</i>.
Tunable Anisotropy in Inverse Opals and Emerging Optical Properties (2014)

Using self-assembly, nanoscale materials can be fabricated from the bottom up. Opals and inverse opals are examples of self-assembled nanomaterials made from crystallizing colloidal particles. As self-assembly requires a high level of control, it is challenging to use building blocks with anisotropic geometry to form complex opals, which limits the possible structures. Typically, spherical colloids are employed as building blocks, leading to symmetric, isotropic superstructures. However, a significantly richer palette of directionally dependent properties are expected if less symmetric, anisotropic structures can be created, especially originating from the assembly of regular, spherical particles. Here we show a simple method for introducing anisotropy into inverse opals by subjecting them to a post-assembly thermal treatment that results in directional shrinkage of the silica matrix caused by condensation of partially hydrated sol–gel silica structures. In this way, we can tailor the shape of the pores, and the anisotropy of the final inverse opal preserves the order and uniformity of the self-assembled structure. Further, we prevent the need to synthesize complex oval-shaped particles and crystallize them into such target geometries. Detailed X-ray photoelectron spectroscopy and infrared spectroscopy studies clearly identify increasing degrees of sol–gel condensation in confinement as a mechanism for the structure change. A computer simulation of structure changes resulting from the condensation-induced shrinkage further confirmed this mechanism. As an example of property changes induced by the introduction of anisotropy, we characterized the optical spectra of the anisotropic inverse opals and found that the optical properties can be controlled in a precise way using calcination temperature.
A simple and efficient enzymatic method for covalent attachment of DNA to cellulose. Application for hybridization-restriction analysis and for in vitro synthesis of DNA probes (1986)

Single-stranded DNAs (ssDNAs) were covalently bound by a simple and efficient enzymatic method to a solid support matrix and used to develop several new procedures for gene analysis. The novel procedure to prepare a ssDNA stably coupled to a solid support employed T4 DNA ligase to link covalently oligo (dT)-cellulose and (dA)-tailed DNA. Beginning with essentially any double stranded DNA the procedure generates a ssDNA linked by its 5' end to a cellulose matrix in a concentration of over 500 ng per mg. DNA from the plasmid pBR322 (4300 bp) and a fragment of the beta-globin gene (1800 bp) were coupled to the solid support and used for several experiments. The ssDNAs on the cellulose efficiently hybridized with as little as 5 pg of complementary double-stranded DNAs. The DNA hybrids formed on the solid support were specifically and efficiently cleaved by restriction endonucleases. These specific restriction cuts were utilized for the diagnosis of correct sequences. In addition, the ssDNA on the solid support served as an efficient template for the synthesis of complementary ssDNAs. The complementary synthesized ssDNAs were uniformly labeled, more than two kilobases in size, and largely full length. About 85% of the ssDNA linked to cellulose was available for the synthesis of complementary DNA, and after strand-separation, the preparation was reusable for the synthesis of additional complementary DNA.
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution (2002)

The structure of RNA polymerase II in a complex with the inhibitor alpha-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury (2016)

Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase-L1 (UCH-L1) have been studied as potential biomarkers of mild traumatic brain injury (mTBI). We report the levels of GFAP and UCH-L1 in patients with acute orthopedic injuries without central nervous system involvement, and relate them to the type of extracranial injury, head magnetic resonance imaging (MRI) findings, and levels of GFAP and UCH-L1 in patients with CT-negative mTBI. Serum UCH-L1 and GFAP were longitudinally measured from 73 patients with acute orthopedic injury on arrival and on days 1, 2, 3, 7 after admission, and on the follow-up visit 3-10 months after the injury. The injury types were recorded, and 71% patients underwent also head MRI. The results were compared with those found in patients with CT-negative mTBI (<i>n</i> = 93). The levels of GFAP were higher in patients with acute orthopedic trauma than in patients with CT-negative mTBI (<i>p</i> = 0.026) on arrival; however, no differences were found on the following days. The levels of UCH-L1 were not significantly different between these two groups at any measured point of time. Levels of GFAP and UCH-L1 were not able to distinguish patients with CT-negative mTBI from patients with orthopedic trauma. Patients with orthopedic trauma and high levels of UCH-L1 or GFAP values may be falsely diagnosed as having a concomitant mTBI, predisposing them to unwarranted diagnostics and unnecessary brain imaging. This casts a significant doubt on the diagnostic value of GFAP and UCH-L1 in cases with mTBI.
Maltooligosaccharides from Corn (2003)

The conversion of cornstarch to maltooligosaccharides is an area of significant commercial interest. The production of maltooligosaccharides on an industrial scale has been practiced for over 30 years. The products are used in a variety of applications, which include the food and pharmaceutical industries. This article will focus on the commercial production, characterization and applications of this product. In addition, recent progress in this area will be summarized.
The Role of Natural Killer Cells in Viral Infections (1997)

Natural killer (NK) cells are important effectors for the lysis of both neoplastic and virus-infected cells. Lectin-like receptors on human NK cells, such as NKR-PIA and CD94, bind to target cell carbohydrate ligands and initiate the lytic process. In addition, P58 and P70 bind to major histocompatibility class I antigens on targets and mediate negative signals. Models using NK cell-deficient mice have proven useful in elaborating the role of NK cells in the immune defence against multiple viral agents. In addition, studies in humans have suggested a vital role of NK cells in the host defence against human immunodeficiency virus, herpesviruses, hepatitis B and C and other viruses. Several genetic disorders, chronic illnesses and infections have been associated with decreased NK function.
Enterprise Software Architecture and Design: Entities, Services, and Resources (2012)

This book fills a gap between high-level overview texts that are often too general and low-level detail oriented technical handbooks that lose sight the "big picture".&amp;nbsp;This book discusses SOA from the low-level perspective of middleware, various XML-based technologies, and basic service design.&amp;nbsp;It also examines broader implications of SOA, particularly where it intersects with business process management and process modeling.&amp;nbsp;Concrete overviews will be provided of the methodologies in those fields, so that students will have a hands-on grasp of how they may be used in the contex
LIGA-based flexible microstructures for fiber-chip coupling (1991)

Moveable and flexible microstructures can be fabricated by a combination of the LIGA process and sacrificial layer techniques. A promising application of such flexible structures can be seen in the field of integrated optics, where the problem of precisely coupling fibers to integrated optical chips still demands a satisfactory solution. In the LIGA structure the fibers are guided by precisely positioned stop faces and then precisely located and prefixed by integrated spring elements. The fabrication of these spring-element arrays by the LIGA process has several advantages: the thermal expansion coefficient of the substrate can be matched to the optical chip material; the use of spring elements for prefixing simplifies the handling; and adhesives and related problems can be avoided. Additionally, a small center spacing of the fibers can be reached with a curved parabolic profile of the spring elements using the LIGA advantage of unrestricted design in the cross-sectional shape. First measurements of load deformation on the spring elements show that the values for the modulus of elasticity and for tensile strength found in literature for bulk nickel can be used for electrodeposited nickel too.
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy (2009)

Cardiac hypertrophy is accompanied by maladaptive cardiac remodeling, which leads to heart failure or sudden death. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that mediate posttranscriptional gene silencing. Recent studies show that miRNAs are involved in the pathogenesis of hypertrophy, but their signaling regulations remain to be understood. Here, we report that miR-23a is a pro-hypertrophic miRNA, and its expression is regulated by the transcription factor, nuclear factor of activated T cells (NFATc3). The results showed that miR-23a expression was up-regulated upon treatment with the hypertrophic stimuli including isoproterenol and aldosterone. Knockdown of miR-23a could attenuate hypertrophy, suggesting that miR-23a is able to convey the hypertrophic signal. In exploring the molecular mechanism by which miR-23a is up-regulated, we identified that NFATc3 could directly activate miR-23a expression through the transcriptional machinery. The muscle specific ring finger protein 1, an anti-hypertrophic protein, was identified to be a target of miR-23a. Its translation could be suppressed by miR-23a. Our data provide a model in which the miRNA expression is regulated by the hypertrophic transcriptional factor.
Hormonal and Feedback Regulation of Putrescine and Spermidine Transport in Human Breast Cancer Cells (1995)

The properties and regulation of the mammalian polyamine transport system are still poorly understood. In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3.7 and 0.5 microM, respectively) via a single class of saturable transporter shared by both substrate types, or via distinct but closely similar carriers. The Vmax, but not the Km of polyamine transport was rapidly and synergistically up-regulated by estrogens and insulin. The steady decay in transport activity observed in hormone-deprived cells was accelerated by retinoic acid. The enhancement of uptake activity resulting from polyamine depletion was amplified 3-fold by estrogens and insulin despite profound growth inhibition, indicating that the cooperative hormonal induction of polyamine transport is dissociated from cell growth status. Polyamine uptake was under feedback inhibition by at least three distinct mechanisms in these cells, namely (i) the induction of a short-lived protein not actively synthesized without ongoing uptake or upon polyamine deletion; (ii) a more latent, protein synthesis-independent "trans-inhibition" mechanism; and (iii) a post-carrier, cycloheximide-sensitive mechanism limiting substrate accumulation. The complexity of these multiple levels of feedback transport inhibition is in keeping with the cytotoxicity of excessive polyamine content.
DEFINITION AND CHARACTERIZATION OF CHICKEN GAL??(1, 3) GAL ANTIBODIES1 (1999)

We now demonstrate that chickens do not express Gal alpha(1,3)Gal on their red cells, leukocytes, or tissues, and that their serum contains large amounts of anti-Gal alpha(1,3)Gal antibodies. In addition, chickens could be immunized to produce high-titer, high-avidity antibodies (9.5x10(9) M(-1))--an avidity considerably greater than that of the Gal alpha(1,3)Gal binding lectin IB4 (2.9x10(8) M(-1)) or Gal antibodies in human serum (2.2x10(5) M(-1)). Chicken antibodies, obtained from both normal and immunized chickens, could block the in vitro cytolysis of pig endothelial cells or lymphocytes by human or baboon antibodies. However, such antibodies tested in vivo in pig-to-baboon xenotransplantation failed to block hyperacute rejection and, indeed, may have accelerated this.