gebhart/patrepeval huggingface dataset:
On the partial stochastic realization problem (1997)

We describe a complete parameterization of the solutions to the partial stochastic realization problem in terms of a nonstandard matrix Riccati equation. Our analysis of this covariance extension equation (CEE) is based on a complete parameterization of all strictly positive real solutions to the rational covariance extension problem, answering a conjecture due to Georgiou (1987) in the affirmative. We also compute the dimension of partial stochastic realizations in terms of the rank of the unique positive semidefinite solution to the CEE, yielding some insights into the structure of solutions to the minimal partial stochastic realization problem. By combining this parameterization with some of the classical approaches in partial realization theory, we are able to derive new existence and robustness results concerning the degrees of minimal stochastic partial realizations. As a corollary to these results, we note that, in sharp contrast with the deterministic case, there is no generic value of the degree of a minimal stochastic realization of partial covariance sequences of fixed length.
Phase Clusters in Large Populations of Chemical Oscillators (2011)

Complex synchronization: Chemical oscillators communicating by exchange of intermediate species through the surrounding solution form clusters of individuals with synchronized oscillations that are out of phase with other clusters. The system evolves from unsynchronized oscillations at low number density n to four, three, two, and finally one cluster with increasing n (see picture).
The rate of telomere sequence loss in human leukocytes varies with age (1998)

A gradual loss of telomeric repeat sequences with aging previously has been noted in normal adult tissues, and this process has been implicated in cell senescence. No data exist that address the rate of telomere shortening in normal human cells within families or early in life. To address these questions, we measured telomere lengths in peripheral blood leukocytes (PBLs) from 75 members of 12 families and in a group of unrelated healthy children who were 5-48 months old. Here we report the surprising observation that rates of telomere attrition vary markedly at different ages. Telomeric repeats are lost rapidly (at a rate of >1 kilobase per year) from the PBLs of young children, followed by an apparent plateau between age 4 and young adulthood, and by gradual attrition later in life. These data suggest that the loss of telomeric repeats in hematopoietic cells is a dynamic process that is differentially regulated in young children and adults. Our results have implications for current models of how telomeric sequences are lost in normal somatic cells and suggest that PBLs are an excellent tissue to investigate how this process is controlled.
Effects of monochromatic low-intensity light and laser irradiation on adhesion of HeLa cells in vitro (1996)

The adhesion was stimulated in the wavelength ranges 600-625, 645-700, and 720-850 nm with maxima at 620, 680, 750, and 820-830 nm, respectively.
A simple method for the isolation of very large numbers of leaf protoplasts by using mixtures of cellulase and pectinase (1969)

the elution profile obtained after hydroxyapatite chromatography.
Annotation-based transcoding for nonvisual web access (2000)

These days, Web authors try to describe as much information as possible in one page using various types of visual effects. This information is visually fragmented into groupings. Blind users read the Web contents in tag order, but visually fragmented groupings are not accessible using tag order reading. In addition, the Web contents are designed to be visually appealing using a lot of images. This style makes nonvisual Web access harder. Therefore we decided to develop an annotation-based transcoding system to convert already-existing Web pages to be accessible, which works between a Web server and a user. It consists of two components, one for structural annotations and one for commentary annotations. Structural annotations are used to recognize visually fragmented groupings as well as to show the importance and basic role of each group. Commentary annotations are used to give users a useful description of each grouping. In this paper, we will describe our transcoding method for nonvisual Web access based on the annotations.
Visualizing Interchange Patterns in Massive Movement Data (2013)

Abstract Massive amount of movement data, such as daily trips made by millions of passengers in a city, are widely available nowadays. They are a highly valuable means not only for unveiling human mobility patterns, but also for assisting transportation planning, in particular for metropolises around the world. In this paper, we focus on a novel aspect of visualizing and analyzing massive movement data, i.e., the interchange pattern, aiming at revealing passenger redistribution in a traffic network. We first formulate a new model of circos figure, namely the interchange circos diagram, to present interchange patterns at a junction node in a bundled fashion, and optimize the color assignments to respect the connections within and between junction nodes. Based on this, we develop a family of visual analysis techniques to help users interactively study interchange patterns in a spatiotemporal manner: 1) multi‐spatial scales: from network junctions such as train stations to people flow across and between larger spatial areas; and 2) temporal changes of patterns from different times of the day. Our techniques have been applied to real movement data consisting of hundred thousands of trips, and we present also two case studies on how transportation experts worked with our interface.
Inhibition of aromatic L-amino acid decarboxylase by coenzyme-amino acid adducts (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of aromatic L-amino acid decarboxylase by coenzyme-amino acid adductsEdwin A. Rudd and John W. ThanassiCite this: Biochemistry 1981, 20, 26, 7469–7475Publication Date (Print):December 1, 1981Publication History Published online1 May 2002Published inissue 1 December 1981https://pubs.acs.org/doi/10.1021/bi00529a022https://doi.org/10.1021/bi00529a022research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Review of the Neuroanatomical Findings in Children with Fetal Alcohol Syndrome or Prenatal Exposure to Alcohol (1998)

Human and animal studies have clearly demonstrated that alcohol is both a physical and behavioral teratogen and that heavy prenatal alcohol exposure can lead to a distinct pattern of birth defects termed the fetal alcohol syndrome. Underlying the behavioral and cognitive anomalies seen in fetal alcohol syndrome are alterations in brain structure and/or function. This paper reviews the literature examining brain anomalies attributable to prenatal alcohol exposure, beginning with a survey of autopsy studies and leading up to current findings using magnetic resonance imaging and positron emission tomography studies. Autopsy reports clearly illustrate the wide and devastating influence alcohol has on the developing brain, although for the most part no specific pattern of brain malformation has been identified. More recent magnetic resonance imaging studies, particularly when combined with quantitative analysis, have indicated that specific brain areas--such as the basal ganglia, the corpus callosum, and parts of the cerebellum--might be especially susceptible to alcohol's teratogenic effects. Further studies using functional brain imaging techniques may provide even more information about the unique effects prenatal alcohol exposure has on the developing brain. Discovering specific areas of the brain that are affected by alcohol may allow clinicians and researchers to look for patterns of vulnerable regions in the brain, thereby helping in the future detection of children who are prenatally exposed to alcohol.
Innate Immunity Genes Influence the Severity of Acute Appendicitis (2004)

Polymorphism in the IL-6 gene was associated with the severity of appendicitis, even after adjustment for duration of symptoms. The risk for developing appendiceal perforation or gangrene may be determined, in part, by variation in the IL-6 gene.
Increased hepatocellular carcinoma risk in chronic hepatitis B patients with persistently elevated serum total bile acid: a retrospective cohort study (2016)

To investigate the association between long-term changes of serum total bile acid and hepatocellular carcinoma in chronic hepatitis B patients, we did a retrospective cohort study of 2262 chronic hepatitis B patients with regular antiviral treatment using data from the Hepatitis Biobank at Southwest Hospital Program from 2004 to 2014. Patients in the study were classified into 3 groups according to persistence of elevated serum total bile acid during follow-up: none-low, medium, and high persistence of elevated serum total bile acid. The association between persistence of elevated serum total bile acid and hepatocellular carcinoma was estimated using Cox proportional hazard models and Kaplan-Meier analysis including information about patients' demographic and clinical characteristics. There were 62 hepatocellular carcinoma cases during a total follow-up of 14756.5 person-years in the retrospective study. Compared to patients with none-low persistence of elevated total bile acid, the multivariate adjusted hazard ratios (95% confidence interval) were 2.37 (1.16-4.84), and 2.57 (1.28-5.16) for patients with medium, and high persistence of elevated total bile acid. Our findings identified persistence of elevated serum total bile acid as an independent risk factor of hepatocellular carcinoma in chronic hepatitis B patients.
Temperature-responsive self-assembly of charged and uncharged hydroxyethylcellulose-graft-poly(N-isopropylacrylamide) copolymer in aqueous solution (2011)

Temperature-induced interchain association and contraction of species in aqueous solutions of charged (MHEC(-)-g-PNIPAAM) and uncharged (MHEC-g-PNIPAAM) modified hydroxyethylcellulose-graft-poly(N-isopropylacrylamide) copolymer have been studied with the aid of turbidimetry and dynamic light scattering (DLS). It was shown that by attaching PNIPAAM chains to the backbone of a hydrophilic cellulose derivative, a strongly temperature-responsive copolymer could be prepared. The results show an intriguing interplay between interchain association and contraction of the multichain species. The transition zone for compression is narrow, and the compaction effect is promoted by a low polymer concentration and charges on the polymer moieties. The findings from DLS revealed two populations of species, namely molecularly dispersed molecules or small clusters and interchain complexes, which exhibit temperature-induced collapse. The magnitude of the cluster contraction can be modulated by changing the polymer concentration and charge density of the copolymer.
Ecto-5′-nucleotidase expression is associated with the progression of renal cell carcinoma (2015)

Renal cell carcinoma (RCC) is a common tissue tumor that occurs across all age groups and has become one of the types of cancer with the fastest increasing incidence. Due to the resistance of RCC chemo- and radiotherapy, surgery is the only currently effective treatment. Therefore, specific markers for the diagnosis and prognosis of RCC are expected to result in novel methods of treatment. Ecto-5'-nucleotidase, also termed cluster of differentiation (CD)73, is a protein that is activated in several types of aggressive cancer and may promote cancer progression. CD73 was examined in the present study to determine the association between the protein and RCC. The expression levels of CD73 in 159 RCC tissue sections and 30 paratumorous normal renal tissue samples obtained from 235 patients that underwent nephrectomy were examined by immunohistochemical staining. By contrast, the expression level of P-glycoprotein (P-gp), a potential prognostic factor in RCC, was also examined in 85 RCC and 13 normal tissue samples. Intense CD73 expression was identified in 75 out of 159 RCC cell membranes compared with normal renal tissues. In contrast, there was high P-gp expression in the blood vessels of 42 out of 85 RCC tissues and there was no significant difference between the P-gp expression identified in RCC cells (34 out of 85) and the cell membrane of normal renal cells (2 out of 13). The expression level of CD73 in RCC cells was significantly associated with tumor type, tumor node metastasis (TNM) stage, and tumor grade. However, the expression of P-gp in RCC cells was only associated with the TNM stage and tumor grade. Using a multivariable Cox regression analysis, it was found that the median survival rate of RCC patients with intense CD73 expression in RCC cells was 62.06±5.35 months, which was drastically shorter compared with rare CD73 expression (103.72±3.67 months). In conclusion, the expression level of CD73 is significantly associated with RCC tumor progression and may serve as a favorable marker for the diagnosis and prognosis of RCC, in addition to being a therapeutic target for the treatment of RCC.
Oral QS-21 Requires Early IL-4 Help for Induction of Mucosal and Systemic Immunity (2001)

The highly purified saponin derivative, QS-21, from the Quillaja saponaria Molina tree has been proved to be safe for parenteral administration and represents a potential alternative to bacterial enterotoxin derivatives as a mucosal adjuvant. Here we report that p.o. administration of QS-21 with the vaccine protein tetanus toxoid elicited strong serum IgM and IgG Ab responses, which were only slightly enhanced by further oral immunization. The IgG Ab subclass responses were predominantly IgG1 followed by IgG2b for the 50-microg p.o. dose of QS-21, whereas the 250-microg p.o. dose also induced IgG2a and IgG3 Abs. Low oral QS-21 doses induced transient IgE Ab responses 7 days after the primary immunization, whereas no IgE Ab responses were seen in mice given the higher QS-21 dose. Further, low but not high p.o. QS-21 doses triggered Ag-specific secretory IgA (S-IgA) Ab responses. Th cell responses showed higher IFN-gamma (Th1-type) and lower IL-5, IL-6, and IL-10 (Th2-type) secretion after the high QS-21 p.o. dose than after low doses. Interestingly, the mucosal adjuvant activity of low oral QS-21 doses was diminished in IL-4(-/-) mice, suggesting a role for this cytokine in the initiation of mucosal immunity by oral QS-21. In summary, our results show that oral QS-21 enhances immunity to coadministered Ag and that different doses of QS-21 lead to distinct patterns of cytokine and serum Ab responses. We also show that an early IL-4 response is required for the induction of mucosal immunity by oral QS-21 as adjuvant.
Distinct Utilization of Effectors and Biological Outcomes Resulting from Site-Specific Ras Activation: Ras Functions in Lipid Rafts and Golgi Complex Are Dispensable for Proliferation and Transformation (2005)

Ras proteins are distributed in different types of plasma membrane microdomains and endomembranes. However, how microlocalization affects the signals generated by Ras and its subsequent biological outputs is largely unknown. We have approached this question by selectively targeting RasV12 to different cellular sublocalizations. We show here that compartmentalization dictates Ras utilization of effectors and the intensity of its signals. Activated Ras can evoke enhanced proliferation and transformation from most of its platforms, with the exception of the Golgi complex. Furthermore, signals that promote survival emanate primarily from the endoplasmic reticulum pool. In addition, we have investigated the need for the different pools of endogenous Ras in the conveyance of upstream mitogenic and transforming signals. Using targeted RasN17 inhibitory mutants and in physiological contexts such as H-Ras/N-Ras double knockout fibroblasts, we demonstrate that Ras functions at lipid rafts and at the Golgi complex are fully dispensable for proliferation and transformation.
Searching for Human Epilepsy Genes: A Progress Report (1993)

Application of new genetic techniques has brought remarkable discoveries in the study of genetic diseases. The potential benefits from applying such technology to idiopathic epilepsies include improved understanding of cellular mechanisms and potential new methods of prevention and treatment. The complex problems involved in studying the hereditary epilepsies include: defining of specific phenotypes; detecting genetic and non-genetic heterogeneity; and specifying the appropriate mode of inheritance and penetrance. The gene loci for three primary epilepsies have been localized to specific chromosomal regions, and serve to demonstrate the process used in generalized linkage studies of hereditary epilepsy syndromes. Benign familial neonatal convulsions (BFNC) and Unverricht-Lundborg progressive myoclonus epilepsy are rare single-gene disorders that are sufficiently localized to chromosomal regions that positional cloning studies are likely to succeed. Juvenile myoclonic epilepsy (JME), a common hereditary syndrome with an uncertain mode of inheritance, has been reported to be linked to chromosome 6p. JME presents a challenge for generalized linkage methodology that may be overcome by attending to potential problems reviewed here. The candidate-gene method, combined with studies using animal models, holds promise for understanding these as well as other hereditary epilepsies.
Can the Acute-Phase Reactant Proteins be Used as Cancer Biomarkers? (2010)

The association between the acute-phase reactant proteins (APRPs) and cancer has long been established. There have been numerous reports correlating altered levels of various APRPs with different types of cancers. However, researchers are often quick to dismiss the use of these APRPs as potential biomarkers for the diagnosis and monitoring of cancer because alterations in APRP concentrations are observed in a wide range of diseases. Recent progress in proteomics studies which profiled the serum proteins of cancer patients and those of normal individuals indicated that the altered APRP expressions were different for distinct types, subtypes, and even stages of cancer. Interestingly, these data are in agreement with those observed earlier using immunochemical and biochemical assays. In view of this compelling association of different patterns of APRPs with various types of cancers and in an apparent shift of paradigm, we present in this review some indications that APRP fingerprinting may be used as complementary cancer biomarkers.
<title>Controlled liquid dosing in microinstruments</title> (1999)

Accurate dosing of liquids in sub-microliter quantities requires a precise measurement of the dispensed quantities. This paper describes applications of a micro flow sensor based on the differential pressure measurement across a fluid restriction. The small size and high accuracy of the flow sensor are very attractive for the integration into sophisticated instrumentation. The use of well-developed hybrid assembly technologies allows for extreme miniaturization and high-density parallel measurements in multi-channel application.
Characterization of the interaction between poly(pyrrole) films and methanol vapor (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of the interaction between poly(pyrrole) films and methanol vaporPatrice Topart and Mira JosowiczCite this: J. Phys. Chem. 1992, 96, 19, 7824–7830Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/j100198a059https://doi.org/10.1021/j100198a059research-articleACS PublicationsRequest reuse permissionsArticle Views194Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Prosthetic hands from Touch Bionics (2008)

Purpose The purpose of this paper is to study the innovative design of prosthetic hands now in production from a Scottish spin‐off company. Design/methodology/approach The novel features are described, followed by the details of the mechanical construction and the available grip patterns. The benefits of the modular design are explained, and the function and construction of a skin‐like covering are explored. The clinical network supporting the prosthesis is briefly outlined. Findings The design allows patients to achieve many functional and natural‐looking hand configurations from simple “open” and “close” signals. Miniature motors and gearboxes allow independent movement of each digit, and an integral microprocessor translates electric signals from the forearm to control the movements of the hand. Stall detection ensures that no finger exerts excessive force or wastes power. Artificial skin can be very realistic, with imitation fingernails, hairs and pores. The lifelike prosthesis helps the patient emotionally, socially and at work. Originality/value The paper shows how advances in motors, gearboxes, batteries and electronics have enabled a breakthrough in prosthetic design.
Pituitary Dwarfism in a Patient with Circulating Abnormal Growth Hormone Polymers (1985)

PITUITARY dwarfism may be due to a deficiency of growth hormone or a lack of peripheral action of growth hormone. Lack of peripheral action of growth hormone may be secondary to an abnormality in the structure of the hormone,1 an inability of growth hormone to generate growth-promoting substances, such as the somatomedins or insulin-like growth factors,2 3 4 or nonresponsiveness of target tissue to these growth-promoting factors.5 The nonresponsiveness of target tissue to growth factors may be due to a defect in the cell-membrane receptors or to any step beyond receptor binding.Although growth hormone deficiency is easily identified by low plasma . . .