gebhart/patrepeval huggingface dataset:
On mixing queries and transactions via multiversion locking (2003)

The authors discuss a novel approach to multiversion concurrency control that allows high-performance transaction systems to support long-running queries. The approach extends the multiversion locking algorithm developed by Computer Corporation of America by using record-level versioning and reserving a portion of each data page for caching prior versions that are potentially needed for the serializable execution of queries; on-page caching also enables an efficient approach to garbage collection of old versions. In addition, view sharing is introduced, which has the potential for reducing the cost of versioning by grouping together queries to run against the same transaction-consistent view of the database. Results from a simulation study that indicate that the approach is a viable alternative to level-one and level-two consistency locking when the portion of each data reserved for prior versions is chosen appropriately are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interaction between web browsers and script engines (2012)

Web browser plays an important part of internet experience and JavaScript is the most popular programming language as a client side script to build an active and advance end user experience. The script engine which executes JavaScript needs to interact with web browser to get access to its DOM elements and other host objects. Browser from host side needs to initialize the script engine and dispatch script source code to the engine side. This thesis studies the interaction between the script engine and its host browser. The shell where the engine address to make calls towards outside is called hosting layer. This report mainly discussed what operations could appear in this layer and designed testing cases to validate if the browser is robust and reliable regarding hosting operations.
Self-interaction correction to density-functional approximations for many-electron systems (1981)

The exact density functional for the ground-state energy is strictly self-interaction-free (i.e., orbitals demonstrably do not self-interact), but many approximations to it, including the local-spin-density (LSD) approximation for exchange and correlation, are not. We present two related methods for the self-interaction correction (SIC) of any density functional for the energy; correction of the self-consistent one-electron potenial follows naturally from the variational principle. Both methods are sanctioned by the Hohenberg-Kohn theorem. Although the first method introduces an orbital-dependent single-particle potential, the second involves a local potential as in the Kohn-Sham scheme. We apply the first method to LSD and show that it properly conserves the number content of the exchange-correlation hole, while substantially improving the description of its shape. We apply this method to a number of physical problems, where the uncorrected LSD approach produces systematic errors. We find systematic improvements, qualitative as well as quantitative, from this simple correction. Benefits of SIC in atomic calculations include (i) improved values for the total energy and for the separate exchange and correlation pieces of it, (ii) accurate binding energies of negative ions, which are wrongly unstable in LSD, (iii) more accurate electron densities, (iv) orbital eigenvalues that closely approximate physical removal energies, including relaxation, and (v) correct longrange behavior of the potential and density. It appears that SIC can also remedy the LSD underestimate of the band gaps in insulators (as shown by numerical calculations for the rare-gas solids and CuCl), and the LSD overestimate of the cohesive energies of transition metals. The LSD spin splitting in atomic Ni and $s\ensuremath{-}d$ interconfigurational energies of transition elements are almost unchanged by SIC. We also discuss the admissibility of fractional occupation numbers, and present a parametrization of the electron-gas correlation energy at any density, based on the recent results of Ceperley and Alder.
Role of the endothelium in inflammatory bowel diseases (2011)

Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease. At the core of these alterations are endothelial cells, whose continual adjustments in structure and function coordinate vascular supply, immune cell emigration, and regulation of the tissue environment. Expansion of the endothelium in IBD (angiogenesis), mediated by inflammatory growth factors, cytokines and chemokines, is a hallmark of active gut disease and is closely related to disease severity. The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines, growth factors, and adhesion molecules, altering coagulant capacity, barrier function and blood cell recruitment in injury. This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions.
Poética publicitaria del consumo (2007)

En este texto, la autora explora los alcances de la produccion artistica como referente de la publicitaria, para la construccion de una sensibilidad contemporanea que emplea el mercado como espacio de socializacion por la via del consumo, en lo que podria entenderse como una estetizacion del discurso de la publicidad- como parte de la mezcla de mercadeo- y de sus fines.
Let's study whole-program cache behaviour analytically (2004)

Based on a new characterisation of data reuse across multiple loop nests, we preset a method, a prototyping implementation and some experimental results for analysing the cache behaviour of whole programs with regular computations. Validation against cache simulation using real codes shows the efficiency and accuracy of our method. The largest program, we have analysed, Applu from SPECfP95, has 3868 lines, 16 subroutines and 2565 references. In the case of a 32KB cache with a 32B line size, our method obtains the miss ratio with an absolute error of about 0.80% in about 128 seconds while the simulator used runs for nearly 5 hours on a 933MHz Pentium. III PC. Our method can be used to guide compiler locality optimisations and improve cache simulation performance.
Grid metadata management: Requirements and architecture (2007)

Metadata annotations of grid resources can potentially be used for a number of purposes, including accurate resource allocation to jobs, discovery of services, and precise retrieval of information resources. In order to realize this potential on a large scale, various aspects of metadata must be managed. These include uniform and secure access to distributed and independently maintained metadata repositories, as well as management of metadata lifecycle. In this paper we analyze these issues and present a service-oriented architecture for metadata management, called S-OGSA, that addresses them in a systematic way.
Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer (2005)

EGFR/FISH seems today to be the best predictive marker for clinical benefit from EGFR inhibitors in NSCLC. Prospective large scale clinical studies must identify the most optimal paradigm for selection of patients.
The influence of genetics on response to treatment with ranibizumab (Lucentis) for age-related macular degeneration: the Lucentis Genotype Study (an American Ophthalmological Society thesis). (2011)

This study is one of the first prospective pharmacogenetic study of intravitreal ranibizumab. Although preliminary, the results identify a number of putative genetic variants, which will be further examined by replication and functional studies to elucidate the complete pharmacogenetic architecture of therapy for AMD.
Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. (1982)

Saccharomyces cerevisiae MATa cells carrying mutations in either sst1 or sst2 are supersensitive to the G1 arrest induced by alpha factor pheromone. When sst1 mutants were mixed with normal SST+ cells, the entire population recovered together from alpha factor arrest, suggesting that SST+ cells helped sst1 mutants to recover. Complementation tests and linkage analysis showed that sst1 and bar1, a mutation which eliminates the ability of MATa cells to act as a "barrier" to the diffusion of alpha factor, were lesions in the same genes. These findings suggest that sst1 mutants, are defective in recovery from alpha factor arrest because they are unable to degrade the pheromone. In contrast, recovery of sst2 mutants was not potentiated by the presence of SST+ cells in mixing experiments. When either normal MATa cells or mutant cells carrying defects in sst1 or sst2 were exposed to alpha factor for 1 h and then washed free of the pheromone, the sst2 cells subsequently remained arrested in the absence of alpha factor for a much longer time than SST+ or sst1 cells. These observations suggest that the defect in sst2 mutants is intrinsic to the cell and is involved in the mechanism of alpha factor action at some step after the initial interaction of the pheromone with the cell. The presence of an sst2 mutation appears to cause a growth debility, since repeated serial subculture of haploid sst2-1 strains led to the accumulation of faster-growing revertants that were pheromone resistant and were mating defective ("sterile").
Desorption electrospray ionization imaging mass spectrometry of lipids in rat spinal cord (2010)

Imaging mass spectrometry allows for the direct investigation of tissue samples to identify specific biological compounds and determine their spatial distributions. Desorption electrospray ionization (DESI) mass spectrometry has been used for the imaging and analysis of rat spinal cord cross sections. Glycerophospholipids and sphingolipids, as well as fatty acids, were detected in both the negative and positive ion modes and identified through tandem mass spectrometry (MS/MS) product ion scans using collision-induced dissociation and accurate mass measurements. Differences in the relative abundances of lipids and free fatty acids were present between white and gray matter areas in both the negative and positive ion modes. DESI-MS images of the corresponding ions allow the determination of their spatial distributions within a cross section of the rat spinal cord, by scanning the DESI probe across the entire sample surface. Glycerophospholipids and sphingolipids were mostly detected in the white matter, while the free fatty acids were present in the gray matter. These results show parallels with reported distributions of lipids in studies of rat brain. This suggests that the spatial intensity distribution reflects relative concentration differences of the lipid and fatty acid compounds in the spinal cord tissue. The "butterfly" shape of the gray matter in the spinal cord cross section was resolved in the corresponding ion images, indicating that a lateral resolution of better than 200 mum was achieved. The selected ion images of lipids are directly correlated with anatomic features on the spinal cord corresponding to the white and the gray matter.
Reduced Central Serotonin Transporters in Alcoholism (1998)

The findings support the hypothesis of serotonergic dysfunction in alcoholism and in withdrawal-emergent depressive symptoms.
Physiological Activity of Docosahexaenoic Acid and Its Production by Microbial Culture (1995)

Docosahexaenoic acid (DHA) has recently attracted nutritional attentions through its specific function in brain/retina as well as beneficial effects of (n-3) polyunsaturated fatty acids. Firstly, the physiological activity of DHA is reviewed from recent publications, and compared to the activity of icosapentaenoic acid (IPA), with respect to its incorporation into plasma/tissues, its anticoagulant/anti-inflammatory effect, its effect on brain/retina, its anticancer effect, and adverse effects of excess intake, if any.Secondly, reports on microbial lipid (single cell oil, SCO) production including DHA are reviewed, which include Crythecodinium cohnii, Thraustochytrium aureum, Vibrio marinus etc. Two trials for DHA-SCO using C. cohnii has revealed high cell/DHA productivities in a semicontinuous culture (50 g/L of cell mass) and a continuous culture (120 mg/L·h of DHA). A new strain, SR 21, isolated from the coral sea water in Yap Islands and identified as Thraustochytrium sp., showed tolerance to high concentration of glucose and to mechanical mixing and resulted in the highest DHA productivity at 4000 mg/L in a fermenter culture for 7 day.
Characterizing white matter connectivity in major depressive disorder: Automated fiber quantification and maximum density paths (2014)

Diffusion-weighted imaging allows for <i>in vivo</i> assessment of white matter structure, which can be used to assess aberrations associated with disease. Several new methods permit the automated assessment of important white matter characteristics. In the current study we used Automated Fiber Quantification (AFQ) to assess differences between depressed and nondepressed individuals in 18 major white matter tracts. We then used the Maximum Density Path (MDP) method to further characterize group differences identified with AFQ. The results of the AFQ analyses indicated that fractional anisotropy (FA; an index of white matter integrity) along bilateral corticospinal tracts (CST) was higher in depressed than in nondepressed individuals. MDP analyses revealed that white matter anomalies were restricted to four subregions that included the corona radiata and the internal and external capsules. These results provide further evidence that MDD is associated with abnormalities in cortical-to-subcortical connectivity.
Coupling confocal fluorescence detection and recirculating microfluidic control for single particle analysis in discrete nanoliter volumes (2008)

The recent proliferation of platforms designed to handle arrays of nano- and picolitre volumes is in response to the need to perform biological assays on discrete entities, such as single cells. However, a critical challenge associated with this trend for in vitro compartmentalization is the need for highly sensitive, yet low-volume detection platforms. In this paper, we coupled confocal fluorescence detection with recirculating microfluidic control to perform single particle DNA assays within five nL chambers. The performance of this low-volume assay was shown to match that of traditional single molecule detection platforms. However, volume requirements per measurement were nearly 3 orders of magnitude less than conventional systems, enabling future integration with lab-on-a-chip systems that require discrete or digitalized sample processing.
Fluconazole and platelet microbicidal protein inhibit Candida adherence to platelets in vitro (1994)

Adherence to vascular endothelium is considered an essential step in the pathogenesis of hematogenously disseminated candidiasis. Platelets have been shown to promote Candida adherence to vascular endothelium in vitro. In contrast, recent studies indicate that platelets may also play a role in the primary host defense against endovascular infection by secretion of alpha granule-derived platelet microbicidal protein (PMP), which possesses both bactericidal and fungicidal activities as well as antiadherence properties. We examined the influences of PMP and the antifungal agent fluconazole on the adherence of Candida albicans to rabbit platelets, as measured by quantitative flow cytometry. In the absence of PMP and fluconazole, adherence of C. albicans to platelets was rapid (complete within 1 min), saturable, and reversible. Following 2 h of exposure to fluconazole at 10x the MIC, platelet binding of C. albicans was substantially reduced (mean reduction, 32.1%; P = 0.08). Similarly, exposure of C. albicans to PMP (range, 0.5 to 5 micrograms/ml) for 2 h (but not 30 min) significantly reduced candidal adherence to platelets 43.1 to 62.1%; (reduction range, P < 0.05). Moreover, exposure of C. albicans to PMP (5 micrograms/ml for 30 min) and then fluconazole (10x the MIC for 2 h) further decreased candidal adherence to platelets in comparison with the adherence after exposure to either agent alone (mean reduction, 57.2%; P = 0.02 and 0.05, respectively). These data demonstrate that PMP and fluconazole individually reduce the ability of C. albicans to bind to platelets in vitro and that the antiadherence activities of fluconazole are augmented by PMP.
Assessment of Insulin Sensitivityin Vivo* (1985)

HISTORICALLY, the study of the pathogenesis of diabetes mellitus was in the traditional pattern of endocrinology: removal of the pancreas led to experimental diabetes, and administration of insulin, a pancreatic isolate, ameliorated the diabetic symptoms (1, 2). These observations led to the widely held belief that human diabetes was primarily a disease of the pancreas, characterized by the inability of the B cell to secrete sufficient insulin to control glycemia. After insulin became available, evidence emerged suggesting that human diabetes mellitus has a multifactorial etiology. Early investigators identified an unexpected variability among diabetics in the ability of injected insulin to ameliorate hyperglycemia (3–5). Larger doses of insulin were required to normalize the blood sugar in patients with the milder nonketotic form of the disease common in the older population, whereas smaller doses were adequate for younger, ketosis-prone diabetics.
Close contact investigation of TB in high-burden, low- and middle-income countries. (2014)

Tuberculosis (TB) remains a very common disease in most of the low- and middle-income countries. As a result of high disease burden, TB control measures in these countries are usually concentrated on intensifying active disease case-finding and early treatment of infectious TB. On the contrary, in countries with low disease burden, the focus is on contact investigation to identify latently infected individuals and prophylactically treating them to prevent disease reactivation and transmission. These two strategies are deemed important for the effective TB control. Nonetheless, WHO cautions that targeted contact investigation and latent TB infection (LTBI) treatment should only be undertaken by countries that have the operational capacity/ resources and have achieved ≥ 85% treatment success rate of active TB. The screening of LTBI is further challenged by the lack of a "gold standard" test to identify and validate individuals with this condition. Tuberculin skin test (TST) is still the preferred investigation as it is cheap, widely available and validated in many trials. The sensitivity and specificity of the newer test-interferon gamma release assay (IGRA) for LTBI screening has been encouraging in low prevalence countries. However, the evidence supporting such usage remains uncertain in high burden settings. Diagnosis of LTBI should adhere to the strict criteria outlined in the guidelines to avoid misdiagnosing active TB as LTBI. The treatment of the latter involved only one or two anti-TB drugs. It has been demonstrated that in the properly conducted contact screening and LTBI treatment, chances of the emergence of multi-drug-resistant TB is very low.
The mechanisms of pyrrole electropolymerization (2000)

Over the past twenty years, polypyrrole has appeared as the most extensively studied conducting polymer. However, despite the volume of work already done in this area, there has been little focus put on the mechanism of polypyrrole synthesis, especially concerning the most efficient method, electropolymerization. Numerous analytical techniques have been used to study polypyrrole electrodeposition and/or doping. However, the mechanism itself is still a controversial subject as there is not one mechanism which is universally accepted. The mechanism proposed by Diaz is the one most commonly referred to in the literature although several other mechanisms are not lacking in support. The controversy lies in the initiation step as each mechanism proposes a different way of beginning the reaction, varying between electron transfer, proton transfer and direct radical pyrrole formation. Without considering the initiation step, there are many other factors including electrolyte, solvent, temperature and pH which can influence the reaction mechanism during the electropolymerization of pyrrole, thus impacting the characteristics of the polymer formed at the electrode.
On the minimal characterization of the rollback-dependency trackability property (2002)

Checkpoint and communication patterns that enforce rollback-dependency trackability (RDT) have only online trackable checkpoint dependencies and allow efficient solutions to the determination of consistent global checkpoints. Baldoni, Helary and Raynal (1998) have explored RDT at the message level, in which checkpoint dependencies are represented by zigzag paths. They have presented many characterizations of RDT and conjectured that a certain communication pattern characterizes the minimal set of zigzag paths that must be tested online by a checkpointing protocol in order to enforce RDT. The contributions of this work are: a proof that their conjecture is false; a minimal characterization of RDT; and introduction of an original approach to analyze RDT checkpointing protocols.
Design and validation of siRNAs and shRNAs. (2009)

RNAi is a highly conserved intracellular mechanism, whereby dsRNA strands conduct post-transcriptional modulation of gene expression through a degradation or inhibition of the translation of target mRNA. Since its discovery in 1998, RNAi has been identified in many different organisms, including mammals, and this mechanism has provided new approaches for studies in cellular and molecular biology, functional genomics and drug discovery. siRNAs can be predicted by sequence and thermodynamic features, and the wide and proficient application of RNAi relies on the ability to select the most active siRNAs from among numerous predicted molecules. Recently, the first-generation prediction algorithms based on the characteristics of siRNAs, short hairpin (sh)RNAs and micro-(mi)RNAs have been improved by the use of computational models that account for the experimentally determined activities of large numbers of siRNAs/shRNAs and miRNAs. These second-generation algorithms differ from the first-generation algorithms in the computational tools that are used for the prediction of siRNA efficacy; although these new algorithms improve the design of effective siRNAs, they do not eliminate the requirement for an experimental evaluation of the activities of siRNAs. This review reports on the most significant second-generation algorithms of siRNA and shRNA characteristics, as well as on recently designed systems for the experimental evaluation of siRNA activities.
Collaborative Systems & Shared Economy (Uberization): Principles & Case Study (2016)

In this paper we analyze the characteristics of collaborative systems and the characteristics of shared economy supporting systems. Uberization as present in many applications: Airbnb, Uber, BlablaCar, AMAP, circular economy, etc. needs a cooperative system support. We examine this approach from the point of view of ICT (Information and Communication Technologies) and, more specifically, HMI (Human Machine Interaction) and CSCW (Computer Supported Cooperative Work) and indicate what must be added to collaborative systems to support uberization. This paper also shows how to identify appropriate collaborative models and how to add new uberization services to obtain an uberization supporting platform. A case of design of a collaborative application for Carbon Free Parcel Distribution is also presented, and corresponding intermediation algorithms are discussed.