gebhart/patrepeval huggingface dataset:
Immunoglobulin G and A Antibody Responses toBacteroides forsythusandPrevotella intermediain Sera and Synovial Fluids of Arthritis Patients (2003)

The objective of the present study was to investigate immunoglobulin G (IgG) and IgA antibody immune responses to Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, and Candida albicans in the sera of patients with rheumatoid arthritis (RA), the synovial fluid (SF) of patients with RA (RA-SF samples), and the SF of patients without RA (non-RA-SF samples). An enzyme-linked immunosorbent assay was used to determine IgG and IgA antibody levels in 116 serum samples from patients with RA, 52 RA-SF samples, and 43 non-RA-SF samples; and these were compared with those in SF samples from 9 patients with osteoarthritis (OA-SF samples) and the blood from 100 donors (the control [CTR] group). Higher levels of IgG antibodies against B. forsythus (P < 0.0001) and P. intermedia (P < 0.0001) were found in non-RA-SF samples than in OA-SF samples, and higher levels of IgG antibodies against B. forsythus (P = 0.003) and P. intermedia (P = 0.024) were found in RA-SF samples than in OA-SF samples. Significantly higher levels of IgA antibodies against B. forsythus were demonstrated in both RA-SF and non-RA-SF samples than in OA-SF samples. When corrected for total Ig levels, levels of IgG antibody against B. forsythus were elevated in RA-SF and non-RA-SF samples compared to those in OA-SF samples. Lower levels of Ig antibodies against B. forsythus were found in the sera of patients with RA than in the plasma of the CTR group for both IgG (P = 0.003) and IgA (P < 0.0001). When corrected for total Ig levels, the levels of IgG and IgA antibodies against B. forsythus were still found to be lower in the sera from patients with RA than in the plasma of the CTR group (P < 0.0001). The levels of antibodies against P. gingivalis and C. albicans in the sera and SF of RA and non-RA patients were comparable to those found in the respective controls. The levels of IgG and IgA antibodies against B. forsythus were elevated in SF from patients with RA and non-RA-SF samples compared to those in OA-SF samples. Significantly lower levels of IgG and IgA antibodies against B. forsythus were found in the sera of patients with RA than in the plasma of the CTR group. This indicates the presence of an active antibody response in synovial tissue and illustrates a potential connection between periodontal and joint diseases.
Using sentiment surveys to predict GDP growth and stock returns (2008)

This important book, prepared under the direction of Nobel Laureate Lawrence R. Klein, shows how economic forecasts are made. It explains how modern developments in information technology have made it possible to forecast frequently – at least monthly but also weekly or bi-weekly – depending upon the perceived needs of potential forecast users and also on the availability of updated material.
A Synthetic Hexadecapeptide Derived from Allergen M Imposing Allergenic and Antigenic Reactivity (1980)

A solid phase synthesis (SPPS) hexadecapeptide corresponding to residues 49-64 of allergen M from cod was found to bind specifically IgE antibodies from sera of cod-allergic individuals. The SPPS peptide was similarly reactive in IgG-mediated reactions; it could interfere with Allergen M line precipitate in rocket-line immunoelectrophoresis, giving a distinct deflection. It is the only reported synthetic polypeptide imposing allergenic and antigenic reactivity. The hexadecapeptide is composed of two homologous tetrapeptides located at its terminai, tentatively concluded to be mutually critical for the immunological specificity. The data obtained confirmed the predicted reactivity of the Ca2+-binding CD loop of the intact Allergen M.
Two Classes of Androgen Receptor Elements Mediate Cooperativity through Allosteric Interactions (2001)

Genes uniquely regulated by the androgen receptor (AR) typically contain multiple androgen response elements (AREs) that in isolation are of low DNA binding affinity and transcriptional activity. However, specific combinations of AREs in their native promoter context result in highly cooperative DNA binding by AR and high levels of transcriptional activation. We demonstrate that the natural androgen-regulated promoters of prostate specific antigen and probasin contain two classes of AREs dictated by their primary nucleotide sequence that function to mediate cooperativity. Class I AR-binding sites display conventional guanine contacts. Class II AR-binding sites have distinctive atypical sequence features and, upon binding to AR, the DNA structure is dramatically altered through allosteric interactions with the receptor. Class II sites stabilize AR binding to adjacent class I sites and result in synergistic transcriptional activity and increased hormone sensitivity. We have determined that the specific nucleotide variation within the AR binding sites dictate differential functions to the receptor. We have identified the role of individual nucleotides within class II sites and predicted consensus sequences for class I and II sites. Our data suggest that this may be a universal mechanism by which AR achieved unique regulation of target genes through complex allosteric interactions dictated by primary binding sequences.
Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer (2007)

Mitotic centromere-associated kinesin (MCAK) is a microtubule (MT) depolymerase necessary for ensuring proper kinetochore MT attachment during spindle formation. To determine MCAK expression status and its clinicopathological significance, real-time reverse transcriptase-polymerase chain reaction was used in 65 cases of gastric cancer. MCAK gene expression in cancer tissue was significantly higher than expression in non-malignant tissue (P<0.05). Elevated MCAK expression was significantly associated with lymphatic invasion (P=0.01) and lymph node metastasis (P=0.04). Furthermore, patients with high MCAK expression had a significantly poorer survival rate than those with low MCAK expression (P=0.008). Immunohistochemical study revealed that expression of MCAK was primarily observed in cancer cells. Additionally, a gastric cancer cell line (AZ521) that stably expressed MCAK was established and used to investigate the biological effects of the MCAK gene. In vitro results showed that cells transfected with MCAK had a high rate of proliferation (P<0.001) and increased migratory ability (P<0.001) compared to mock-transfected cells. This study demonstrated that elevated expression of MCAK may be associated with lymphatic invasion, lymph node metastasis, and poor prognosis. These characteristics may be due in part to the increased proliferative and migratory ability of cells expressing MCAK.
Cyclodextrins and Their Complexes (2006)

The ability of cyclodextrins, CyDs, to form inclusion complexes with a wide variety of hydrophobic guest molecules has been used in agriculture.Their ability to alter the physical, chemical, and biological properties of guest molecules has been used for the preparation of new formulations of pesticides.CyDs form complexes with a wide variety of agricultural chemicals including herbicides, insecticides, fungicides, repellents, pheromones, and growth regulators [1,2].Each CyD has its own ability to form inclusion complexes with specific pesticides, depending on a proper fit of the pesticide molecule into the hydrophobic CyD cavity.The principal advantage is that the binding of pesticide molecules within the host molecule is not fixed or permanent but rather is a dynamic equilibrium.Dissociation of the inclusion complex is a relatively rapid process usually driven by a large increase in the number of water molecules in the surrounding environment [3].aAQ16.3.1aSimilarly to CyD applications in the pharmaceutical (Chapters 14 and 15) and other industries, the most common benefits of CyD applications in agriculture include, among others, alterations of the solubility of the pesticide, stabilization against the effects of light or biochemical degradation, and a reduction of volatility.In some applications, more than one benefit is obtained by complexation with CyDs.However, the application of these hosts in pesticide formulations is very modest, and represents less than 1% of the CyD literature [4].Moreover, most of these publications are not directly practice oriented.Instead they deal with the preparation of pesticides@CyD complexes using different oligosaccharides and processing methods and their characterization using a wide variety of techniques.Among these papers, some are more or less theoretical papers dealing with the correlation between the properties of the new complexes obtained and the properties of the CyDs, pesticides, or external parameters used.Viernstein et al.
Pathogenicity and immunogenicity of a mutagen-attenuated Rift Valley fever virus immunogen in pregnant ewes (1987)

A mutagenized clone of Rift Valley fever virus (RVFV; MV P12) used in inoculation of 3 pregnant ewes was immunogenic, nonpathogenic, and nonabortogenic. In contrast, inoculation of a matched group of 3 pregnant ewes with parent RVFV induced clinical disease and abortions. Ewes given MV P12 delivered healthy lambs that had RVFV antibody titers of less than 1:10 at birth, increasing to greater than or equal to 1:80 after ingestion of colostrum. Ewes inoculated with parent RVFV developed marked viremia, followed by RVFV antibody titers greater than or equal to 1:1,280; ewes inoculated with MV P12 developed low viremia titers and RVFV antibody titers of 1:80 to 1:320. Postpartum challenge exposure of the previously MV P12-inoculated ewes with virulent Zagazig human 501 strain RVFV indicated that the ewes were protected from clinical disease. The RVFV-susceptible female Culex pipiens that fed on the MV P12-inoculated ewes failed to transmit RVFV to hamsters; mosquitoes that fed on the parent RVFV-inoculated ewes became infected and transmitted RVFV to hamsters.
The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction (2015)

Results suggest the importance of the NLRP3 inflammasome in the induction of inflammation and bladder dysfunction secondary to bladder outlet obstruction. Arresting these processes with NLRP3 inhibitors may prove useful to treat the symptoms that they produce.
Randomized Trial of Effect of Alendronate Continuation Versus Discontinuation in Women With Low BMD: Results From the Fracture Intervention Trial Long-Term Extension (2004)

Compared with women who stopped alendronate after an average of 5 years, those continuing alendronate maintained a higher BMD and greater reduction of bone turnover, showing benefit of continued alendronate treatment on BMD and bone turnover. On discontinuation of alendronate therapy, rates of change in BMD at the hip and spine resumed at the background rate, but discontinuation did not result in either accelerated bone loss or a marked increase in bone turnover, showing persistence of alendronate's effects on bone. Data on the effect of continuation versus discontinuation on fracture risk are needed before making definitive recommendations regarding the optimal length of alendronate treatment.
Gastric colonization by Campylobacter pylori subsp. mustelae in ferrets (1988)

Campylobacter pylori subsp. mustelae was cultured from both normal and inflamed gastric mucosa of ferrets. Examination of neonatal, juvenile, and adult ferrets established that the gastric mucosa in the majority of preweanling (age, less than 6 weeks) ferrets sampled were not colonized with C. pylori subsp. mustelae, whereas the gastric mucosa of 100% of adult ferrets were colonized with this gastric organism. C. pylori subsp. mustelae was isolated from the gastric mucosa on a sequential basis from nine ferrets during a several-month period, inferring either persistent colonization or frequent reinfection with C. pylori subsp. mustelae.
Morphometric and mechanical properties of femora in young adult male turkeys with and without femoral fractures (2000)

Morphologic and torsional mechanical properties of femora were evaluated in three groups of turkeys to determine whether turkeys that incurred femoral fracture have different radiographic, morphologic, and torsional mechanical properties than do turkeys without femoral fracture, and if body weight was a factor differentiating affected and nonaffected turkeys. Nine turkeys with unilateral femoral fractures and nine turkeys without fractures from Farm A were compared with a group of nine age and genetically matched turkeys from Farm B. Turkeys from Farm A were 10 to 25% heavier (26.2+/-0.9 kg) and turkeys from Farm B were 10% lighter (18.2+/-0.9 kg) than expected breed standards. Femoral length, cortical thickness, medullary diameter, and diaphyseal curvature were measured from craniocaudal and lateromedial radiographs. One intact femur from each of five turkeys with a contralateral femoral fracture (Farm A), nine unaffected turkeys from Farm A, and nine turkeys from Farm B were subjected to failure in a torsion test. Geometric and mechanical results were compared. Turkeys from Farm A had a thicker cortex and a smaller medullary diameter than turkeys from Farm B. Turkeys from Farm A had significantly lower torsional stiffness and failure torque values compared with turkeys from Farm B, when differences in body weight were accounted for (analysis of covariance, P < 0.05). Mechanical failure torque calculated from geometric values suggests that organic or inorganic material arrangement and composition may be responsible, in part, for differences between groups. Femoral fractures may be associated with insufficient skeletal adaptation to heavy body weight.
Large-scale, heterogeneous integration of nanowire arrays for image sensor circuitry (2008)

We report large-scale integration of nanowires for heterogeneous, multifunctional circuitry that utilizes both the sensory and electronic functionalities of single crystalline nanomaterials. Highly ordered and parallel arrays of optically active CdSe nanowires and high-mobility Ge/Si nanowires are deterministically positioned on substrates, and configured as photodiodes and transistors, respectively. The nanowire sensors and electronic devices are then interfaced to enable an all-nanowire circuitry with on-chip integration, capable of detecting and amplifying an optical signal with high sensitivity and precision. Notably, the process is highly reproducible and scalable with a yield of approximately 80% functional circuits, therefore, enabling the fabrication of large arrays (i.e., 13 x 20) of nanowire photosensor circuitry with image-sensing functionality. The ability to interface nanowire sensors with integrated electronics on large scales and with high uniformity presents an important advance toward the integration of nanomaterials for sensor applications.
Correlated link shadow fading in multi-hop wireless networks (2009)

Accurate representation of the physical layer is required for analysis and simulation of multi-hop networking in sensor, ad hoc, and mesh networks. Radio links that are geographically proximate often experience similar environmental shadowing effects and thus have correlated shadowing. This paper presents and analyzes a non-site-specific statistical propagation model which accounts for the correlations that exist in shadow fading between links in multi-hop networks. We describe two measurement campaigns to measure a large number of multi-hop networks in an ensemble of environments. The measurements show statistically significant correlations among shadowing experienced on different links in the network, with correlation coefficients up to 0.33. Finally, we analyze multi-hop paths in three and four node networks using both correlated and independent shadowing models and show that independent shadowing models can underestimate the probability of route failure by a factor of two or greater.
A Genetically Defined Model for Human Ovarian Cancer (2004)

Disruptions of the p53, retinoblastoma (Rb), and RAS signaling pathways and activation of human telomerase reverse transcriptase (hTERT) are common in human ovarian cancer; however, their precise role in ovarian cancer development is not clear. We thus introduced the catalytic subunit of hTERT, the SV40 early genomic region, and the oncogenic alleles of human HRAS or KRAS into human ovarian surface epithelial cells and examined the phenotype and gene expression profile of those cells. Disruption of p53 and Rb pathway by SV40 early genomic region and hTERT immortalized but did not transform the cells. Introduction of HRAS(V12) or KRAS(V12) into the immortalized cells, however, allowed them to form s.c. tumors after injection into immunocompromised mice. Peritoneal injection of the transformed cells produced undifferentiated carcinoma or malignant mixed Mullerian tumor and developed ascites; the tumor cells are focally positive for CA125 and mesothelin. Gene expression profile analysis of transformed cells revealed elevated expression of several cytokines, including interleukin (IL)-1beta, IL-6, and IL-8, that are up-regulated by the nuclear factor-kappaB pathway, which is known to contribute to the tumor growth of naturally ovarian cancer cells. Incubation with antibodies to IL-1beta or IL-8 led to apoptosis in the ras-transformed cells and ovarian cancer cells but not in immortalized cells that had not been transformed. Thus, the transformed human ovarian surface epithelial cells recapitulated many features of natural ovarian cancer including a subtype of ovarian cancer histology, formation of ascites, CA125 expression, and nuclear factor-kappaB-mediated cytokine activation. These cells provide a novel model system to study human ovarian cancer.
Piezoelectric properties of irradiation-crosslinked polypropylene ferroelectrets (2007)

The cellular irradiation-cross-linked polypropylene films treated by a hot-press process are corona charged to be piezoelectric. For the samples charged at room temperature, quasistatic piezoelectric d33 coefficients up to 400pC∕N are obtained. The d33 coefficients are slightly dependent on pressure in the range up to 50kPa. The d33 values decrease to 30% when the samples are exposed to 90°C for 1day; a preaging treatment improves the thermal stability of d33. The dominant drift path of the detrapped charges is from one void surface to the adjacent void surface through the bulk of the solid.
Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19 (2022)

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Despite the rapid global spread of COVID-19 vaccines, effective oral antiviral drugs are urgently needed. Here, we describe the discovery of S-217622, the first oral non-covalent, non-peptidic SARS-CoV-2 3CL protease inhibitor clinical candidate. S-217622 was discovered via virtual screening followed by biological screening of an in-house compound library, and optimization of the hit compound using a structure-based drug-design strategy. S-217622 exhibited antiviral activity in vitro against current outbreaking SARS-CoV-2 variants and showed favorable pharmacokinetic profiles in vivo for once-daily oral dosing. Furthermore, S-217622 dose-dependently inhibited intrapulmonary replication of SARS-CoV-2 in mice, indicating that this novel non-covalent inhibitor could be a potential oral agent for treating COVID-19.
Integrins: cell adhesion molecules in cancer (1998)

The metastatic process is the major cause of mortality in cancer patients. Metastasis involves tumour cell adhesion to other cells and extracellular matrix glycoproteins, and eventual invasion through basement membranes. Such interactions may be mediated by a great variety of cell surface biomolecules, including integrins. The development of integrin antagonists offers a promising strategy to inhibit metastasis. Potential integrin-based therapeutics include synthetic peptides that have been modified via cyclisation, or inclusion of all-D amino acids, as well as a variety of organic molecules. Issues of specificity have been addressed and ligands that bind to only one particular integrin have been isolated. Improved bioavailability appears to be the next area for consideration to create efficient delivery of potential antimetastatic compounds.
Induced changes of leukocyte slow rolling in an in flow pharmacological model of adhesion to endothelial cells (2003)

When the drug had been added to endothelial cells a shift of velocities was observed towards fast speeds (from 3-5 to 7-11 microm/sec). The same results was significantly found when neutrophils, alone or along with endothelium, had been submitted to the drug, the number of stickers and rollers beeing reduced as well. Finally, such a precise pharmacological method proved efficient to detect the exact mechanism of INO5042 on white cell adhesion.
The clearinghouse (1983)

The problem of naming and locating objects in a distributed environment is considered, and the clearinghouse, a decentralized agent for supporting the naming of these "network-visible" objects, is described. The objects "known" to the clearinghouse are of many types and include workstations, file servers, print servers, mail servers, clearinghouse servers, and human user. All objects known to the clearinghouse are named using the same convention, and the clearinghouse provides information about objects in a uniform fashion, regardless of their type. The clearinghouse also supports aliases.
The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β1-Lipoprotein into Subfractions of Human Plasma (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β1-Lipoprotein into Subfractions of Human PlasmaJ. L. Oncley, M. Melin, D. A. Richert, J. W. Cameron, and P. M. GrossCite this: J. Am. Chem. Soc. 1949, 71, 2, 541–550Publication Date (Print):February 1, 1949Publication History Published online1 May 2002Published inissue 1 February 1949https://pubs.acs.org/doi/10.1021/ja01170a048https://doi.org/10.1021/ja01170a048research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations343LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overweight, Obesity, and Neighborhood Characteristics among Postpartum Latinas (2013)

The body adiposity of these Latina mothers was coupled with low levels of social support from family and friends and neighborhood characteristics that were unfavorable to walking.