gebhart/patrepeval huggingface dataset:
SHOULD WE EVALUATE ALCOHOL TREATMENT PROGRAMMES IN AUSTRALIA, AND IF SO, HOW? (1985)

ABSTRACT The various alcohol treatment evaluation studies which have been conducted in Australia are briefly reviewed. Next it is asserted that we should only evaluate programmes in Australia if the content of the programme is different to that of the many overseas programmes evaluated and if there is reason to believe that the Australian programme is having a beneficial effect. Seven methodological issues whiich are encountered during evaluation studies are then considered, together with the industrial relations aspect of such research.
Design of a Wideband Millimeter Wave Micromachined Rotman Lens (2015)

Design, fabrication, and performance of a micromachined millimeter wave Rotman lens are presented. To achieve wide instantaneous bandwidth with ±30° scan range, five different transmission lines with carefully designed transitions are monolithically integrated within the same process. Theoretical bandwidth of over 70 GHz is verified with a narrower bandwidth W-band measurements of VSWR (<;2.75:1), and 65-115 GHz measurements of realized gain (5-11 dBi), 3 dB beamwidth (20°-40°), and beam-peak locations in E-plane. Demonstrated results indicate that wideband Rotman lenses can now be engineered for emerging millimeter and submillimeter wave applications.
Quantitation of Hepatitis B Viremia and Emergence of YMDD Variants in Patients with Chronic Hepatitis B Treated with Lamivudine (1999)

Hepatitis B viremia and emergence of hepatitis B virus (HBV) YMDD variants with reduced susceptibility to lamivudine were analyzed in patient sera from a phase II study of extended lamivudine therapy. Within 12 weeks, all patients exhibited a marked virologic response to lamivudine: >99% reduction (median 5 log decrease) in serum HBV DNA levels. Virus remained at >104 genomes/mL in 11 patients and decreased to <104 genomes/mL in the remaining 12 patients. In 10 patients, detectable YMDD variants emerged during the course of treatment. Six patients, including 3 with YMDD variants, experienced hepatitis B e antigen seroconversion while on lamivudine therapy or soon after its discontinuation. No patients with HBV DNA levels >104 genomes/mL seroconverted. Thus, patients who respond to lamivudine therapy with dramatic reductions in viral DNA level (to <104 genomes/mL) appear more likely to seroconvert than patients who do not achieve this level of HBV clearance.
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation (2012)

Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a reactive metabolite that binds to proteins. In rodents, this leads to mitochondrial dysfunction and nuclear DNA fragmentation, resulting in necrotic cell death. While APAP metabolism is similar in humans, the later events resulting in toxicity have not been investigated in patients. In this study, levels of biomarkers of mitochondrial damage (glutamate dehydrogenase [GDH] and mitochondrial DNA [mtDNA]) and nuclear DNA fragments were measured in plasma from APAP-overdose patients. Overdose patients with no or minimal hepatic injury who had normal liver function tests (LTs) (referred to herein as the normal LT group) and healthy volunteers served as controls. Peak GDH activity and mtDNA concentration were increased in plasma from patients with abnormal LT. Peak nuclear DNA fragmentation in the abnormal LT cohort was also increased over that of controls. Parallel studies in mice revealed that these plasma biomarkers correlated well with tissue injury. Caspase-3 activity and cleaved caspase-3 were not detectable in plasma from overdose patients or mice, but were elevated after TNF-induced apoptosis, indicating that APAP overdose does not cause apoptosis. Thus, our results suggest that mitochondrial damage and nuclear DNA fragmentation are likely to be critical events in APAP hepatotoxicity in humans, resulting in necrotic cell death.
The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT (2001)

Costimulatory molecules on antigen-presenting cells (APCs) play an important role in T cell activation and expansion. However, little is known about the surface molecules involved in direct T-T cell interaction required for their activation and expansion. LIGHT, a newly discovered TNF superfamily member (TNFSF14), is expressed on activated T cells and immature dendritic cells. Here we demonstrate that blockade of LIGHT activity can reduce anti-CD3-mediated proliferation of purified T cells, suggesting that T cell-T cell interaction is essential for this proliferation. To test the in vivo activity of T cell-derived LIGHT in immune homeostasis and function, transgenic (Tg) mice expressing LIGHT in the T cell lineage were generated. LIGHT Tg mice have a significantly enlarged T cell compartment and a hyperactivated peripheral T cell population. LIGHT Tg mice spontaneously develop severe autoimmune disease manifested by splenomegaly, lymphadenopathy, glomerulonephritis, elevated autoantibodies, and severe infiltration of various peripheral tissues. Furthermore, the blockade of LIGHT activity ameliorates the severity of T cell-mediated diseases. Collectively, these findings establish a crucial role for this T cell-derived costimulatory ligand in T cell activation and expansion; moreover, the dysregulation of T cell-derived LIGHT leads to altered T cell homeostasis and autoimmune disease.
The biology of hepatocyte growth factor/scatter factor (1992)

Abstract Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The membrane receptor for hepatocyte growth factor/scatter factor has been identified as the c‐ met proto‐oncogene product.
Learning similarity metrics for event identification in social media (2010)

Social media sites (e.g., Flickr, YouTube, and Facebook) are a popular distribution outlet for users looking to share their experiences and interests on the Web. These sites host substantial amounts of user-contributed materials (e.g., photographs, videos, and textual content) for a wide variety of real-world events of different type and scale. By automatically identifying these events and their associated user-contributed social media documents, which is the focus of this paper, we can enable event browsing and search in state-of-the-art search engines. To address this problem, we exploit the rich "context" associated with social media content, including user-provided annotations (e.g., title, tags) and automatically generated information (e.g., content creation time). Using this rich context, which includes both textual and non-textual features, we can define appropriate document similarity metrics to enable online clustering of media to events. As a key contribution of this paper, we explore a variety of techniques for learning multi-feature similarity metrics for social media documents in a principled manner. We evaluate our techniques on large-scale, real-world datasets of event images from Flickr. Our evaluation results suggest that our approach identifies events, and their associated social media documents, more effectively than the state-of-the-art strategies on which we build.
Progesterone Differentially Regulates Pro- and Anti-Apoptotic Gene Expression in Cerebral Cortex Following Traumatic Brain Injury in Rats (2005)

Although the administration of progesterone has been shown to be neuroprotective in experimental models of traumatic brain injury (TBI), the mechanisms for this beneficial effect are still poorly understood. The present study examined the effects of progesterone on mRNA and protein levels of the Bcl-2 apoptosis regulatory genes, bax, bad, bcl-2, and bcl-x(L), in cerebral cortex after TBI. Male Sprague-Dawley rats were subjected to either sham surgery or lateral fluid percussion brain injury of moderate severity (2.4-2.6 atm). Within 1 h post-surgery, progesterone (4 mg/kg) or vehicle (corn oil) administration was initiated for 1-7 days postoperatively. Our results indicate that bax and bad mRNA levels and Bax and Bad protein expression in the ipsilateral, injured cerebral cortex were significantly elevated post-TBI, while mRNA levels of bcl-2 and bcl-x(L) or Bcl-2 and Bcl-x(L) protein expression were not changed. Under the sham-treated condition, progesterone significantly increased mRNA levels of the anti-apoptotic gene, bcl-2, but down-regulated pro-apoptotic gene expression (bax and bad) in cerebral cortex. After TBI, progesterone treatment reduced bax and bad mRNA levels in the ipsilateral cerebral cortex of TBI rats, and decreased Bax and Bad protein levels. In addition, bcl-2 and bcl-x(L) mRNA levels, as well as Bcl-2 and Bcl-x(L) protein expression, were increased by progesterone in TBI injured cortex. These data indicate that one of the neuroprotective mechanisms of progesterone may be related to its differential regulation of apoptotic signals.
Comparative evaluation of urokinase‐type plasminogen activator receptor expression in primary breast carcinomas and on metastatic tumor cells (2003)

The urokinase-type plasminogen activator receptor (uPAR, CD87) plays a central role in the plasminogen activation cascade, which participates in extracellular matrix degradation, cell migration and invasion. Here we performed a comprehensive immmunohistochemical evaluation of uPAR expression in primary tumor cells, tumor-surrounding fibroblasts, lymph node metastases and micrometastatic cells in bone marrow of patients with breast carcinomas at the time of primary diagnosis. Variable degrees of uPAR staining of tumor cells were observed in 84 of 93 (90%) carcinomas, whereas intratumoral fibroblasts were uPAR-positive in 70 (75%) carcinomas. The fraction of uPAR-positive primary tumor cells but not fibroblasts was positively correlated with the presence of tumor cells in bone marrow (p = 0.037), whereas no correlation with lymph node metastasis was found. Immunophenotyping of bone marrow and lymph node specimens revealed expression of uPAR on metastatic tumor cells in 10 of 13 and 22 of 23 cases, respectively. Direct comparison to the autologous primary tumor cells showed different uPAR staining scores in most patients with evidence for both up- and downregulation of uPAR on metastatic cells. Our results indicate that uPAR plays an active role in breast cancer metastasis and may therefore be a promising target for new biologic therapies.
Transient Pressure Analysis: Finite Conductivity Fracture Case Versus Damaged Fracture Case (1981)

ABSTRACT This work presents the basic pressure behavior differences between a finite conductivity fracture and different types of damaged fractures. Two kinds of fracture damage conditions are studied: a) a damaged zone around the fracture, and b) a damaged zone within the fracture in the vicinity of the wellbore. The first case is caused by the fracturing fluid loss in the formation and the last case is originated by crushing, embedding or loss of propant within the fracture in the vicinity of the wellbore. This paper emphasizes that although finite fracture conductivity and fracture damage condition are both flow restrictions, their effects on transient pressure behavior are quite different at early time. Type curves and both linear flow and bilinear flow graphs can be used to identify different cases when applied properly.
Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection. (1995)

Human herpesvirus 6 (HHV-6), a T-lymphotropic human herpesvirus, is a potentially immunosuppressive agent that has been suggested to play a role as a cofactor in the natural history of human immunodeficiency virus (HIV) infection. We studied the interactions between HHV-6 and gamma/delta T lymphocytes, a subset of T cells involved in the protective immune response against specific microorganisms. Polyclonal gamma/delta T cell populations, purified from the peripheral blood of healthy adults and activated in vitro with phytohemagglutinin, were exposed to HHV-6, strain GS (subgroup A), at the approximate multiplicity of infection (MOI) of 1. Signs of virus replication were detected as early as 72 h after infection, as documented by immunofluorescence, electron microscopy, and transmission of extracellular virus. Progression of the infection was associated with the appearance of typical cytomorphological changes and, eventually, massive cell death. In contrast, no signs of infection or cytopathic effects were detected after exposure of gamma/delta T lymphocytes to HHV-7, a CD4+ T-lymphotropic virus closely related to HHV-6. Polyclonal gamma/delta T cells displayed cytolytic activity against both autologous and heterologous target cells infected with HHV-6 and maintained this activity for at least 72 h after infection with HHV-6, despite the high MOI used. As previously documented in mature CD8+ alpha/beta T cells and natural killer cells, HHV-6 infection induced gamma/delta T lymphocytes to express de novo CD4 messenger RNA and protein, as detected by reverse transcriptase-polymerase chain reaction and fluorocytometry, respectively. Whereas purified CD4- gamma/delta T cell populations were per se refractory to HIV infection, they became susceptible to productive infection by HIV-1, strain IIIB, after induction of CD4 expression by HHV-6. These results demonstrate that gamma/delta T cells can be directly targeted and killed by a herpesvirus and may have implications for the potential role of HHV-6 in AIDS.
Glypican-3 as a novel target for an antibody-drug conjugate (2007)

656 A novel oncofetal antigen Glypican-3 (GPC-3) has been reported to be highly expressed in primary hepatocellular carcinoma (HCC) and melanoma. Our data using a commercial anti-GPC-3 mAb confirmed a strong signal in 70% of HCC tumors tested by immunohistochemistry. Expression profiling of 32 normal human tissues showed that expression of GPC-3 was restricted to placenta and faint cytoplasmic staining in normal kidney. We also evaluated breast, lung, uterus and ovarian cancer tissue microarrays for GPC-3 expression. Thirty-two out of 42 ovarian tumors (76%) showed elevated GPC-3 expression. We found moderate to high levels of expression of GPC-3 in HCC, colon cancer and melanoma cell lines and undetectable levels in normal renal cells by quantitative FACS. Using an anti-GPC-3 mAb conjugated to the potent cytotoxic agent monomethylauristatin F, we showed specific growth inhibition of GPC-3+ cells in vitro, thus indicating internalization of the antibody-target complex. With the restricted normal tissue expression of GPC-3 and efficient internalization of the antibody-drug conjugate (ADC), an anti-GPC-3 ADC may be useful for targeted therapy of hepatocellular carcinomas. Possible additional indications are in ovarian cancer and melanomas.
Optical detection of antibody-antigen reactions at a glass-liquid interface. (1984)

We describe an optical technique for detecting and monitoring antibody-antigen reactions at a solid-liquid interface. The antibody is covalently immobilized onto the surface of either a planar (microscope slide) or cylindrical (fibre optic) waveguide made of fused quartz. The reaction of immobilized antibody with antigen in solution is detected through use of the evanescent wave component of a light beam, which has a characteristic depth of penetration of a fraction of a wavelength into the aqueous phase, thus optically interacting primarily with substances bound (or located very close) to the interface and only minimally with the bulk solution. This resulting in-situ spatial separation of the antibody-bound from free antigen precludes a formal separation step and allows the reaction to be monitored kinetically. An immunoassay for methotrexate by absorption spectrometry achieved a detection limit of about 270 nmol/L; binding of methotrexate by immobilized antibody was monitored by the decrease in transmittance at 310 nm. A two-site immunofluorometric assay for human IgG could detect as little as 30 nmol/L; binding of fluorescein-labeled antibody was monitored by the increase in signal above 520 nm (lambda ex = 495 nm). With both immunoassays the signal-generating phase was monitored kinetically and was completed within 15 min.
Relating the Hadamard Variance to MCS Kalman Filter Clock Estimation (1995)

The Global Positioning System (GPS) Master Control Station (MCS) currently makes significant use of the Allan Variance. This two-sample variance equation has proven excellent as a handy, understandable tool, both for time domain analysis of GPS cesium frequency standards, and for fine tuning the MCS's state estimation of these atomic clocks. The Allan Variance does not explicitly converge for the nose types of alpha less than or equal to minus 3 and can be greatly affected by frequency drift. Because GPS rubidium frequency standards exhibit non-trivial aging and aging noise characteristics, the basic Allan Variance analysis must be augmented in order to (a) compensate for a dynamic frequency drift, and (b) characterize two additional noise types, specifically alpha = minus 3, and alpha = minus 4. As the GPS program progresses, we will utilize a larger percentage of rubidium frequency standards than ever before. Hence, GPS rubidium clock characterization will require more attention than ever before. The three sample variance, commonly referred to as a renormalized Hadamard Variance, is unaffected by linear frequency drift, converges for alpha is greater than minus 5, and thus has utility for modeling noise in GPS rubidium frequency standards. This paper demonstrates the potential of Hadamard Variance analysis in GPS operations, and presents an equation that relates the Hadamard Variance to the MCS's Kalman filter process noises.
Psoriasis: a review of present and future management (1998)

Psoriasis is a chronic skin condition prevalent in a significant minority of the population. Its cause is unknown and effective treatments are elusive. In this article, the authors examine the impact of the disease on patients' lives and describe how unproven treatments make skilled nursing essential for people with such a challenging and disabling disease.
Hematopoiesis and angiogenesis. (2000)

Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system during organogenesis. Hematopoietic stem cells have been shown to originate from the para-aortic splanchnopleural mesoderm region or aorta-gonads-mesonephros at successive stages. We discuss the molecular events in the differentiation of hematopoietic cells and endothelial cells. Transcription factors SCL/tal-1 and AML1; tyrosine kinase receptors Flk-1, Tie-2, Eph, and the sialomucins; CD34; thrombomucin; and AA4 play important biological roles in these lineages.
Hierarchical Variational Models (2015)

Black box variational inference allows researchers to easily prototype and evaluate an array of models. Recent advances allow such algorithms to scale to high dimensions. However, a central question remains: How to specify an expressive variational distribution that maintains efficient computation? To address this, we develop hierarchical variational models (HVMs). HVMs augment a variational approximation with a prior on its parameters, which allows it to capture complex structure for both discrete and continuous latent variables. The algorithm we develop is black box, can be used for any HVM, and has the same computational efficiency as the original approximation. We study HVMs on a variety of deep discrete latent variable models. HVMs generalize other expressive variational distributions and maintains higher fidelity to the posterior.
An analysis of wide-area name server traffic (1992)

Over a million computers implement the Internet's Domain Name System of DNS, making it the world's most distributed database and the Internet's most significant source of wide-area RPC-like traffic. Last year, over eight percent of the packets and four percent of the bytes that traversed the NSFnet were due to DNS. We estimate that a third of this wide-area DNS traffic was destined to seven root name servers. This paper explores the performance of DNS based on two 24-hour traces of traffic destined to one of these root name servers. It considers the effectiveness of name caching and retransmission timeout calculation, shows how algorithms to increase DNS's resiliency lead to disastrous behavior when servers fail or when certain implementation faults are triggered, explains the paradoxically high fraction of wide-area DNS packets, and evaluates the impact of flaws in various implementations of DNS. It shows that negative caching would improve DNS performance only marginally in an internet of correctly implemented name servers. It concludes by calling for a fundamental change in the way we specify and implement future name servers and distributed applications.
Local Recurrence After Hepatic Radiofrequency Coagulation (2005)

Radiofrequency coagulation by laparoscopy or laparotomy results in superior local control, independent of tumor size. The percutaneous route should mainly be reserved for patients who cannot tolerate a laparoscopy or laparotomy. The short-term benefits of less invasiveness for the percutaneous route do not outweigh the longer-term higher risk of local recurrence.
WCDMA Design Handbook (2005)

Developed out of a successful professional engineering course, this practical handbook was originally published in 2005, and provides a comprehensive explanation of the Wideband CDMA (Code Division Multiple Access) air interface of 3rd generation UMTS cellular systems. The book addresses all aspects of the design of the WCDMA radio interface from the lower layers to the upper layers of the protocol architecture. It considers each of the layers in turn, to build a complete understanding of the design and operation of the WCDMA radio interface including the physical layer, RF and baseband processing, MAC, RLC, PDCP/BMP, Non-Access stratum and RRC. An ideal course book and reference for professional engineers, undergraduate and graduate students.