gebhart/patrepeval huggingface dataset:
COMBINATORIAL CATALYSTS (1996)

RETURN TO ISSUEPREVNewsNEXTCOMBINATORIAL CATALYSTSMethods devised to create arrays of catalysts to screen for enantioselective activitySTU BORMANView Author Information C&EN Washington Cite this: Chem. Eng. News 1996, 74, 45, 37–39Publication Date (Print):November 4, 1996Publication History Published online12 November 2010Published inissue 4 November 1996https://pubs.acs.org/doi/10.1021/cen-v074n045.p037https://doi.org/10.1021/cen-v074n045.p037newsACS PublicationsCopyright © 1996 American Chemical SocietyArticle Views12Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Catalysts Get e-Alerts
Substituted dihydrobenzopyran and dihydrobenzofuran thiazolidine-2,4-diones as hypoglycemic agents (1991)

A series of dihydrobenzofuran and dihydrobenzopyran thiazolidine-2,4-diones (compounds 3-26) was synthesized from the corresponding aryl aldehydes 1 in two steps. These compounds represent conformationally restricted analogues of the novel hypoglycemic ciglitazone. The series was evaluated by hypoglycemic effects in vitro by measuring stimulation of 2-deoxyglucose uptake in L6 myocytes and stimulation of expression of the glucose transporter protein in 3T3-L1 adipocytes. In vivo hypoglycemic effects were evaluated in the genetically obese ob/ob mouse, and structure-activity relationships are discussed. On the basis of this in vivo potency, we have selected the 2(R)-benzylbenzopyran derivative to be further studied in a clinical setting.
Interpretation of Static Time-of-Flight Secondary Ion Mass Spectra of Adsorbed Protein Films by Multivariate Pattern Recognition (2002)

Multivariate analysis has become increasingly common in the analysis of multidimensional spectral data. We previously showed that the multivariate analysis technique principal component analysis (PCA) is an excellent method for interpreting the static time-of-flight secondary ion mass spectrometry (TOF-SIMS) spectra of adsorbed protein films. PCA is an unsupervised pattern recognition technique that loses resolution between spectra of different proteins as more proteins are added to the data set due to large within-group variation. The supervised pattern recognition techniques discriminant principal component analysis (DPCA) and linear discriminant analysis (LDA), which aim to control within-group variation while maximizing between-group separation to enhance discrimination between groups, were compared with PCA using data sets of TOF-SIMS spectra of proteins adsorbed onto mica and PTFE substrates. DPCA and LDA quantitatively improved discrimination between groups and provided different information about the data than PCA. LDA was able to classify unknown samples with a misclassification rate lower than PCA or DPCA. Both unsupervised and supervised pattern recognition techniques are useful for the interpretation and classification of static TOF-SIMS spectra of adsorbed protein films.
Semantic repository modeling in image database (2005)

This work is about content based image database retrieval, focusing on developing a classification based methodology to address semantics-intensive image retrieval. With self organization map based image feature grouping, a visual dictionary is created for color, texture, and shape feature attributes, respectively. Labeling each training image with the keywords in the visual dictionary, a classification tree is built. Based on the statistical properties of the feature space we define a structure, called /spl alpha/-semantics graph, to discover the hidden semantic relationships among the semantic repositories embodied in the image database. With the /spl alpha/-semantics graph, each semantic repository is modeled as a unique fuzzy set to explicitly address the semantic uncertainty and the semantic overlap existing among the repositories in the feature space. A retrieval algorithm combining the classification tree with the fuzzy set models to deliver semantically relevant image retrieval is provided. The experimental evaluations have demonstrated that the proposed approach models the semantic relationships effectively and outperforms a state-of-the-art content based image retrieval system in the literature both in effectiveness and efficiency.
XENOTRANSPLANTATION (1993)

The dramatic development of liver transplantation compared to a relative shortage of donors has brought a renewed interest to xenotransplantation. Because of anatomical and immunological compatibilities, nonhuman primates are the most appropriate donors. The aim of this work was to analyze the different problems of a baboon-to-man liver xenotransplantation. Thirty baboons bred in a French Primatology Center were studied. The analysis of anatomical, microbiological, and immunological data showed that only 8 baboons out of 30 were suitable as donors for xenotransplantation. Considering these data and the ethical issues, the actual feasibility of xenotransplantation programs is discussed.
Synthesis and conversion of 2-methyl-2-(3-oxobutyl)-1,3-cyclopentanedione to the isomeric racemic ketols of the [3.2.1]bicyclooctane and of the perhydroindane series (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and conversion of 2-methyl-2-(3-oxobutyl)-1,3-cyclopentanedione to the isomeric racemic ketols of the [3.2.1]bicyclooctane and of the perhydroindane seriesZoltan G. Hajos and David R. ParrishCite this: J. Org. Chem. 1974, 39, 12, 1612–1615Publication Date (Print):June 1, 1974Publication History Published online1 May 2002Published inissue 1 June 1974https://pubs.acs.org/doi/10.1021/jo00925a002https://doi.org/10.1021/jo00925a002research-articleACS PublicationsRequest reuse permissionsArticle Views2683Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Light reflection functions for simulation of clouds and dusty surfaces (1982)

The study of the physical process of light interacting with matter is an important part of computer image synthesis since it forms the basis for calculations of intensities in the picture. The simpler models used in the past are being augmented by more complex models gleaned from the physics literature. This paper is another step in the direction of assimilating such knowledge. It concerns the statistical simulation of light passing through and being reflected by clouds of similar small particles. (It does not, however, address the cloud structure modeling problem). By extension it can be applied to surfaces completely covered by dust and is therefore a physical basis for various theories of diffuse reflection.
[The molecular design and drug development of recombinant long-acting follicle stimulating hormone]. (2012)

Follicle-stimulating hormone (FSH) is a glycoprotein which regulates the development, growth, pubertal maturation and reproductive processes of the body. Exogenous FSH has been used to promote ovarian follicular growth and maturation in female and spermatogenesis in male. The relative short elimination half life and rapid metabolic clearance of current versions of FSH require a daily or twice-daily scheduled subcutaneous injection to maintain stable FSH level being not below the threshold during ovarian stimulation. The development of recombinant long-acting FSH with enhanced biological activities may be helpful for less injection therefore to improve patient compliance, while reducing patient stress and error rates. A number of technological strategies have been explored to develop recombinant longer-acting FSH. For examples, attachment of the C-terminal peptide (CTP) of the human chorionic gonadotropin beta subunit or a sequence containing potential glycosylation sites to either subunit of FSH, creation of a single chain containing the alpha and beta subunits of FSH combined with CTP or N-linked glycosylation signal sequence as a linker, or fusion of the Fc domain of IgGi to FSH. Based on the modifiable molecular structure and pharmacokinetic and pharmacodynamic properties of recombinant FSH, it is hopeful that more FSH drugs with prolonged half-life and increased bioactivity will be developed to meet the modern clinical demands.
Towards Single-Copy Gene Expression Systems Making Gene Cloning Physiologically Relevant: Lambda InCh, a Simple Escherichia coli Plasmid-Chromosome Shuttle System (2000)

ABSTRACT We describe a simple system for reversible, stable integration of plasmid-borne genes into the Escherichia coli chromosome. Most ordinary E. coli strains and a variety of pBR322-derived ampicillin-resistant plasmids can be used. A single genetic element, a lambda phage, is the only specialized vector required. The resultant strains have a single copy of the plasmid fragment inserted stably at the lambda attachment site on the chromosome, with nearly the entire lambda genome deleted.
Heptane-Soluble Ring-Closing Metathesis Catalysts (2007)

Terminally vinyl-functionalized polyisobutylene (PIB) oligomers can be easily transformed into end-functionalized PIB-bound Ru metathesis catalysts. The nonpolar catalysts so prepared can be used as solutions in heptane and recycled by a gravity-based extraction after addition of a heptane-immiscible polar solvent. This paper describes the synthesis and the recycling of a PIB-supported second-generation Hoveyda-Grubbs catalyst for Ru-catalyzed ring-closing metathesis and ring-opening metathesis polymerizations.
The Use of Electrolyzed Solutions for the Cleaning and Disinfecting of Dialyzers (2000)

Recently, the use of electrolyzed solutions has attracted considerable interest in Japan. This study investigates the efficiency of electrolyzed solutions as disinfecting agents (DA) in the reuse of dialyzers and compares their efficiency to that of other disinfectants currently in use. The following 3 methods were employed. First, the rinsing time and rebound release of reused dialyzers were measured and compared after electrolyzed solutions, electrolyzed strong acid aqueous solution (ESAAS) and electrolyzed strong basic aqueous solution (ESBAS), made from reverse osmosis (RO) water (ESAAS, ESBAS; Generating apparatuses: Super Oxseed alpha 1000, Amano Corporation, Yokohama, Japan), 2% Dialox-cj (Teijin Gambro Medical, Tokyo, Japan), and 3.8% formalin were used as DAs. This involved performing dialysis with 2 types of dialyzers: a cellulose acetate membrane (CAM) dialyzer and a polysulfone membrane (PSM) dialyzer. The dialyzers were cleaned and disinfected using the different DA and left for 48 h. Next, after performing dialysis the dialyzer membranes were cleaned with a saline solution (0.9% NaCl) and RO water and then cleaned with the various DA. These membranes were observed using a scanning electron microscope (SEM) to check for the presence of physical and biological contaminants. Finally, in vitro tests were performed to determine the level of dialyzer clearance when PSM dialyzers were reused after having been cleaned and disinfected with the electrolyzed solutions. The rinsing time results for both the CAM and PSM dialyzers showed the electrolyzed solutions (ESBAS and ESAAS) as being undetectable within 10 min. With regard to the rebound release, for both the CAM and PSM dialyzers, the electrolyzed solutions were undetectable at all checking times between 30 and 240 min. Observation by SEM showed that cleaning with both ESAAS and ESBAS left the fewest contaminants, and cleaning with 2% Dialox-cj left the highest level of contaminants in the CAM dialyzers. With regard to experiments concerning use in vitro, no major changes in the dialyzer clearance were noticed after 6 uses. In every experiment, the previous investigations showed the electrolyzed solutions to be superior to 3. 8% formalin and 2% Dialox-cj DA for the reuse of dialyzers.
Coloring register pairs (1992)

Many architectures require that a program use pairs of adjacent registers to hold double-precision floating-point values. Register allocators based on Chaitin's graph-coloring technique have trouble with programs that contain both single-register values and values that require adjacent pairs of registers. In particular, Chaitin's algorithm often produces excessive spilling on such programs. This results in underuse of the register set; the extra loads and stores inserted into the program for spilling also slow execution. An allocator based on an optimistic coloring scheme naturally avoids this problem. Such allocators delay the decision to spill a value until late in the allocation process. This eliminates the over-spilling provoked by adjacent register pairs in Chaitin's scheme. This paper discusses the representation of register pairs in a graph coloring allocator. It explains the problems that arise with Chaitin's allocator and shows how the optimistic allocator avoids them. It provides a rationale for determining how to add larger aggregates to the interference graph.
Enhanced tumor suppressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein. (1996)

The preclinical studies presented here demonstrate that treatment of human non-small cell lung carcinoma and bladder carcinoma cells by a recombinant adenovirus vector, AdCMVpRB94, expressing the N-terminal truncated retinoblastoma (RB) protein (pRB94) completely suppressed the tumorigenicity of the treated tumor cells in nude mice. Furthermore, gene therapy of established human RB- and RB+ bladder xenograft cancers in nude mice by AdCMVpRB94 resulted in regression of the treated tumors. Of note, although both the full-length and the truncated forms of the RB protein, when overexpressed in tumor cells via replication-deficient adenovirus vectors, were capable of suppression of tumor growth, the pRB94 was evidently more potent than the full-length RB protein.
Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts (2014)

None.
A Study on Crime Victims' Right to State (2013)

Abstract It was just over 20 years ago that the victim who had been seen as the forgotten man in criminal justice system for a long time started to participate in criminal proceedings and state his opinion. Other countries such as America and Japan provide crime victims with the opportunity to state freely about facts of damage as well as their opinions in criminal proceedings at present. However, Korea gives the victim the right of statement as a witness, though the statement of crime victim’s opinion is the constitutional right. That is, as crime victims are not free from perjury they cannot actively state their views. Meanwhile, if the freedom of crime victims’ statement is guaranteed in law and victims can state opinions with their own voice, victims’statement of opinion will help the victims treat and relieve their psychological damages. For these reasons, it is desirable that Korea, like the U.S. and Japan, gives crime victims the right to state their opinion without fear of perjury in criminal proceedings not as witnesses but as the aggrieved party.
Regulation of Sterol Synthesis in Eukaryotes (2007)

Cholesterol is an essential component of mammalian cell membranes and is required for proper membrane permeability, fluidity, organelle identity, and protein function. Cells maintain sterol homeostasis by multiple feedback controls that act through transcriptional and posttranscriptional mechanisms. The membrane-bound transcription factor sterol regulatory element binding protein (SREBP) is the principal regulator of both sterol synthesis and uptake. In mammalian cells, the ER membrane protein Insig has emerged as a key component of homeostatic regulation by controlling both the activity of SREBP and the sterol-dependent degradation of the biosynthetic enzyme HMG-CoA reductase. In this review, we focus on recent advances in our understanding of the molecular mechanisms of the regulation of sterol synthesis. A comparative analysis of SREBP and HMG-CoA reductase regulation in mammals, yeast, and flies points toward an equilibrium model for how lipid signals regulate the activity of sterol-sensing proteins and their downstream effectors.
Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins (2006)

Following the discovery of protein modification by the small, highly conserved ubiquitin polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function as protein modifiers as well. These Ubls, which include SUMO, ISG15, Nedd8, and Atg8, function as critical regulators of many cellular processes, including transcription, DNA repair, signal transduction, autophagy, and cell-cycle control. A growing body of data also implicates the dysregulation of Ubl-substrate modification and mutations in the Ubl-conjugation machinery in the etiology and progression of a number of human diseases. The primary aim of this review is to summarize the latest developments in our understanding of the different Ubl-protein modification systems, including the shared and unique features of these related pathways.
Adaptation of the tail suspension test to the rat. (1987)

In the tail suspension test (TST), the rat is suspended by the tail for 6 min during which the animal shows periods of agitation and immobility. The duration of the immobility is measured. Desipramine decreased the duration of immobility. The main advantages of this procedure are: the use of a simple, objective test situation; the concordance of the results (for desipramine) with the "behavioral despair" test described by Porsolt; the avoidance of the hypothermia induced by immersion in the Porsolt test.
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange (2009)

RAD51, an essential eukaryotic DNA recombinase, promotes homologous pairing and strand exchange during homologous recombination and the recombinational repair of double strand breaks. Mutations that up- or down-regulate RAD51 gene expression have been identified in several tumors, suggesting that inappropriate expression of the RAD51 activity may cause tumorigenesis. To identify chemical compounds that affect the RAD51 activity, in the present study, we performed the RAD51-mediated strand exchange assay in the presence of 185 chemical compounds. We found that 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) efficiently inhibited the RAD51-mediated strand exchange. DIDS also inhibited the RAD51-mediated homologous pairing in the absence of RPA. A surface plasmon resonance analysis revealed that DIDS directly binds to RAD51. A gel mobility shift assay showed that DIDS significantly inhibited the DNA-binding activity of RAD51. Therefore, DIDS may bind near the DNA binding site(s) of RAD51 and compete with DNA for RAD51 binding.
Effects of Tort Liability and Insurance on Heavy Drinking and Drinking and Driving (1995)

Using self-reported data on patterns of alcohol use among individuals from the 1989-90 Behavioral Risk Factor Surveys, this study investigates effects of tort liability and third- and first-party insurance, alcohol prices, and criminal sanctions on frequency of binge drinking and driving under the influence of alcohol (DUI). Requiring drivers to purchase third-party insurance discouraged binge drinking, especially in states combining compulsory insurance with a surcharge for a DUI. Implementation of no-fault laws and switching from contributory to comparative negligence increased binge drinking, while higher alcohol prices reduced it. With one exception, neither tort nor nontort deterrents affected the fraction of bingeing episodes after which the individual drove. Overall, it appears that deterrence of DUI is achieved by curbing behavior that leads to DUI, namely, binge drinking. Once individuals engage in binge drinking, it appears that many policies designed to be deterrents have little influence.
mRNA amplification system by viral replicase in transgenic plants (1993)

We have constructed transgenic tobacco plants (M1x2-FCP2IFN plants) expressing viral RNA replication genes of brome mosaic virus (BMV) and BMV RNA3 derivative (FCP2IFN) carrying the human gamma interferon (IFN-gamma) gene. In M1x2-FCP2IFN plants the RNA3 derivative expressed from the integrated cDNA was replicated and subgenomic RNA (i.e. mRNA of IFN-gamma) was produced by BMV replicase. The accumulation level of the mRNA of IFN-gamma was approximately 5-fold higher than that by the cauliflower mosaic virus (CaMV) 35S RNA promoter. In addition IFN-gamma accumulated in M1x2-FCP2IFN plants.
32‐3: AMOLED IR Drop Compensation for Channel Length Modulation (2020)

This paper proposed a new approach to compensate IR‐Drop on AMOLED panel for CLM (channel length modulation). IR drop will cause the luminance non‐uniformity problem. Moreover, the interaction between IR‐Drop and CLM make the phenomenon worse. If we compensate IR‐Drop but ignore CLM, the color shift happened even though the brightness uniformity gets better. Therefore, CLM compensation value must be analyzed and applied to solve this problem. Experimental results show that our approach improve color shift and keep the brightness uniformity.