gebhart/patrepeval huggingface dataset:
Pharmacological enhancement of cognitive and behavioral deficits after traumatic brain injury (2006)

The clinician trying to ameliorate the cognitive and behavioral symptoms of traumatic brain injury has to make decisions about pharmacotherapy that are still based mainly on clinical experience. Large randomized controlled trials giving high-quality evidence are so far missing. This review discusses the problems facing both the clinician and the scientist treating the cognitive and behavioral sequels of traumatic brain injury. A symptom-based approach is suggested for current practice.
Context-aware Models for Twitter Sentiment Analysis (2015)

Recent works on Sentiment Analysis over Twitter are tied to the idea that the sentiment can be completely captured after reading an incoming tweet. However, tweets are filtered through streams of posts, so that a wider context, e.g. a topic, is always available. In this work, the contribution of this contextual information is investigated for the detection of the polarity of tweet messages. We modeled the polarity detection problem as a sequential classification task over streams of tweets. A Markovian formulation of the Support Vector Machine discriminative model has been here adopted to assign the sentiment polarity to entire sequences. The experimental evaluation proves that sequential tagging better embodies evidence about the contexts and is able to increase the accuracy of the resulting polarity detection process. These evidences are strengthened as experiments are successfully carried out over two different languages: Italian and English. Results are particularly interesting as the approach is flexible and does not rely on any manually coded resources.
Oleosin KD 18 on the surface of oil bodies in maize. Genomic and cDNA sequences and the deduced protein structure. (1990)

Oleosins are newly discovered, abundant, and small Mr hydrophobic proteins localized on the surface of oil bodies in diverse seeds. So far, most of the studies have been on the general characteristics of the proteins, and only one protein (maize KD 16) has been studied using a cDNA clone containing an incomplete coding sequence. Here, we report the sequences of a genomic clone and a cDNA clone of a new maize oleosin (KD 18). There is no intron in the gene. The 5'-flanking region contains potential regulatory elements including RY repeats, CACA consensus, and CATC boxes, which are presumably involved in the specific expression of the proteins in maturing seeds. The deduced amino acid sequence was analyzed for secondary structures. We suggest that KD 18 of 187-amino acid residues contains three major structural domains: a largely hydrophilic domain at the N terminus, a hydrophobic hairpin alpha-helical domain at the center, and an amphipathic alpha-helix domain at the C terminus. These structural domains are very similar to those of oleosin KD 16. However, the KD 18 and KD 16 amino acid sequences as well as nucleotide sequences are highly similar only at the central domain (72 and 71%, respectively). The similarities are highest at the loop region of the alpha-helical hairpin. These results suggest that KD 18 and KD 16 are isoforms, encoded by genes derived from a common ancestor gene. We propose that the hairpin domain acts as an indispensible internal signal for intracellular trafficking of oleosins during protein synthesis as well as an anchor for oleosins on the oil bodies. The other two domains can undergo relatively massive amino acid substitutions without impairing the structure/function of the oleosins or have evolved to generate oleosins having different functions.
Haze-free polymer dispersed liquid crystals utilizing linear polarizers (1992)

Polymer dispersed liquid crystal (PDLC) light shutters are scattering in the OFF state and transparent in the ON state for normally incident light. PDLC shutters appear hazy in the ON state when viewed at oblique angles as a result of light scattering. The haze is caused by the effective increase in the refractive index of the liquid crystal. However, only one polarization of the incident radiation is scattered. Therefore, PDLC shutters with a linearly polarized sheet on the incident surface are haze-free for an entire viewing plane. While addition of a polarizer reduces transmission through the PDLC to less than 50%, it also offers a simple means of producing haze-free PDLC shutters for applications where viewing is predominantly in one plane.
The Drilling Command and Control System (1985)

ABSTRACT The best-Laid plans in drilling are often defeated by at least three major problems: (1) information scarcity – poor communication between rig and office hinders attempts to make good decisions; voluminous historical files yield little practical information, (2) data saturation – nobody can digest all of the real time data now available at the rig site, and (3) technology lag – the gap widens between what is technically feasible and what is routinely achieved. The Drilling Command and Control (DCC) system has been developed to mitigate these problems. Drilling Command and Control combines the best available computer, video, and satellite technologies to provide quality communications, reduce large volumes of data to practical use, and actively tracks all phases of the drilling operation. Its foremost feature is ease of use, as demonstrated by contract personnel who learn to perform at full capabilities within two weeks of DCC experience. This paper describes both the unique Drilling Command and Control system and its novel applications to drilling.
A load balancing tool based on mining access patterns for Distributed File System servers (2003)

In this paper we present a new web based Distributed File System server management tool to perform load balancing across multiple servers. The Distributed File System from Distributed Computing Environment (DCE DFS) is a collection of many file systems mounted onto a single virtual file system space with a single namespace. The tool is based on rule-based data mining techniques and graph analysis algorithms. The data mining procedures identify DFS file access patterns and the graph analysis and statistical information relocates the filesets between different file servers. We demonstrate our tool on data collected for five months on DFS servers in a production environment. Experiments with this data show that our load balancing tool is useful to file system administrators to monitor, evaluate DFS state and to make intelligent decisions about file system transfers in order to balance the access request load on "read-write" filesets across DFS servers.
The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. (1994)

Balb/c 3T3 cells transformed by the tsA58 temperature-sensitive (ts) mutant of SV40 large T antigen, BalbA58 cells, grow in 1% serum at the permissive temperature of 34 degrees C but fail to grow at the restrictive temperature of 39.6 degrees C. Although incapable of growing, BalbA58 cells, in low serum at 39.6 degrees C, still synthesize DNA and tend to accumulate in the G2 phase of the cell cycle. Growth in 1% serum at 39.6 degrees C resumes if BalbA58 cells are treated with insulin-like growth factor I (IGF-I). By using cells overexpressing the IGF-I receptor, and cells with a targeted disruption of the IGF-I receptor genes, we show that: 1) the activation of the IGP-I receptor by its ligand(s) plays a major role in the ability of the SV40 large T antigen to promote growth in low serum; and 2) the IGF-I receptor plays a role in the progression of cells not only through G1, but also through the S and G2 phases of the cell cycle. These findings, together with other recent findings from the literature, suggest that one of the mechanisms by which oncogenes and tumor suppressor genes regulate cell growth is through the modulation of growth factors and their receptors.
Histone HI - DNA interaction.Influence of phosphorylation on the interaction of histone HI with linear fragmented DNA (1977)

By measuring the fluorescence polarization of fluorescent histone H1 derivatives complexed with DNA, binding of the histone to DNA was studied as a function of ionic strength in the solution prior to and after the H1 phosphorylation on Ser-37 residue. Fluorescent labels were covalently linked either specifically to Tyr-72 residues or unspecifically to lysine residues in the H1 polypeptide chain. The values of the corresponding rotational relaxation times showed that at low ionic strength all the segments of the H1 molecule were immobilized on binding to DNA. The gradual increasing NaC1 concentration in the solution of H1-DNA complex was accompanied at first by additional retardation of the histone mobility in the complex, and then by progressive release of histone H1 from from the complex which was completed at 0.5-0.6 M NaC1 irrespective of phosphorylation. tat the same time the phosphorylation of histone H1 led to removal of the central and, presumably, N-terminal regions of H1 from DNA.
1,2-Alkanediol Bis(Dihydrogen Phosphates) (1988)

Abstract Preparation of bis(dihydrogen phosphates) of 1,2-ethanediol and 1,2-propanediol are reported.
Persistence length and scaling properties of single-stranded DNA adsorbed on modified graphite (2009)

We have characterized the polymer physics of single-stranded DNA (ssDNA) using atomic force microscopy. The persistence length l(p) of circular ssDNA adsorbed on a modified graphite surface was determined independently of secondary structure. At a very low ionic strength we obtained l(p)=9.1 nm from the bond correlation function. Increasing the salt concentration lead to a decrease in l(p); at 1 mM NaCl we found l(p)=6.7 nm, while at 10 mM NaCl a value l(p)=4.6 nm was obtained. The persistence length was also extracted from the root-mean-square end-to-end distance and the end-to-end distance distribution function. Finally, we have investigated the scaling behavior using the two latter quantities, and found that on long length scales ssDNA behaves as a two-dimensional self-avoiding walk.
Performance tradeoffs between maximum ratio transmission and switched-transmit diversity (2002)

Implementation of maximum ratio transmission (MRT) systems is not a trivial task. Alternatively, switched-transmitter diversity (STD) systems are less difficult to implement, but their performance is suboptimal when compared to MRT systems. If the difference is not significant, implementation advantages of STD systems outweigh the minor performance loss so that these systems are desirable for practical implementations. This paper compares the performances between MRT and STD systems under Rayleigh-fading conditions for 2/spl times/1, 2/spl times/2 and 4/spl times/ (transmit antennas/spl times/receive antennas) configurations. It is found that the differences are only about 1 dB for the 2/spl times/1 and 2/spl times/2 configurations, indicating that implementation simplicity of a STD system can be utilized without sacrificing too much performance. However, the difference is around 3 dB for the 4/spl times/ configuration. The considerably larger loss prompts system designers to consider more critically on the tradeoffs between implementation aspects and performances of STD and MRT systems.
False-negative cytology rates in patients in whom invasive cervical cancer subsequently developed. (1982)

The 3-year screening interval recommended by the American Cancer Society would appear to decrease the detection of premalignant and malignant disease. The authors have shown that 20% of study patients in whom subsequently invasive cervical cancer developed had at least 2 negative Papanicolaou smears within 3 years of the diagnosis of cancer. Moreover, the majority of false-negative results in the series could be attributed to sample error. The authors recommend yearly or at least biennial cervical cytologic screening.
Neurotransmitters and Epilepsy (1987)

The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotr
Volatile Anesthetic Binding to Proteins Is Influenced by Solvent and Aliphatic Residues (2008)

The main objective of this work was to characterize VA binding sites in multiple anesthetic target proteins. A computational algorithm was used to quantify the solvent exclusion and aliphatic character of amphiphilic pockets in the structures of VA binding proteins. VA binding sites in the protein structures were defined as the pockets with solvent exclusion and aliphatic character that exceeded minimum values observed in the VA binding sites of serum albumin, firefly luciferase, and apoferritin. We found that the structures of VA binding proteins are enriched in these pockets and that the predicted binding sites were consistent with experimental determined binding locations in several proteins. Autodock3 was used to dock the simulated molecules of 1,1,1,2,2-pentafluoroethane, difluoromethyl 1,1,1,2-tetrafluoroethyl ether, and sevoflurane and the isomers of halothane and isoflurane into these potential binding sites. We found that the binding of the various VA molecules to the amphiphilic pockets is driven primarily by VDW interactions and to a lesser extent by weak hydrogen bonding and electrostatic interactions. In addition, the trend in Delta G binding values follows the Meyer-Overton rule. These results suggest that VA potencies are related to the VDW interactions between the VA ligand and protein target. It is likely that VA bind to sites with a high degree of solvent exclusion and aliphatic character because aliphatic residues provide favorable VDW contacts and weak hydrogen bond donors. Water molecules occupying these sites maintain pocket integrity, associate with the VA ligand, and diminish the unfavorable solvation enthalpy of the VA. Water molecules displaced into the bulk by the VA ligand may provide an additional favorable enthalpic contribution to VA binding. Anesthesia is a component of many health related procedures, the outcomes of which could be improved with a better understanding of the molecular targets and mechanisms of anesthetic action.
Genetic analysis of the proBA genes of Salmonella typhimurium: physical and genetic analyses of the cloned proB+ A+ genes of Escherichia coli and of a mutant allele that confers proline overproduction and enhanced osmotolerance (1983)

Because of the fact that proline overproduction relieves the inhibitory effects of high external osmotic strength in a number of procaryotes, we wished to clone a mutant allele, pro-74, that confers proline overproduction and enhanced osmotolerance on Salmonella typhimurium and Escherichia coli. Therefore, the pro-74 allele, originally located on an E. coli episome F'128, was cloned into pBR322. In a parallel experiment, the wild type proB+ A+ genes of E. coli were also cloned from F'128 into pBR322. Both the pro-74 and the proB+ A+ alleles were obtained on a 10.4-kilobase-pair fragment that also contained the unrelated phoE gene. Strains carrying either the wild-type proB+ A+ or the pro-74 alleles on pBR322 grew more slowly, both in minimal medium and media of elevated osmotic strength, than strains carrying the same alleles on the low-copy plasmid, F'128, indicating that some gene in the cloned region is deleterious in high copy. We constructed Tn5 insertion mutations in the proB and the proA genes of E. coli, carried on F'128 in S. typhimurium. Using P22 transduction in S. typhimurium, we transferred these proB and proA::Tn5 insertions from F'128 into the cloned proBA genes on pBR322. From the restriction maps of the plasmids thus generated, we determined the approximate locations of the proB and the proA genes. We also performed complementation tests of S. typhimurium and E. coli proB and proA mutants by using the F'128 proB and proA::Tn5 insertions. These tests revealed that the proBA genes of S. typhimurium form an operon, whose direction of transcription is from proB to proA. They also indicated that in S. typhimurium, as in E. coli, the proB+ gene encodes gamma-glutamyl kinase, and the proA+ gene encodes gamma-glutamyl phosphate reductase. Complementation tests also indicated that the pro-74 mutation is either in the proB structural gene, or its promoter-operator.
The structure of polymyxin S1. Studies on antibiotics from the genus Bacillus. XXI. (1977)

Amino acid analysis on the acid hydrolyzate of polymyxin S1 revealed its amino acid composition. Isolation of the constituent amino acids and measurement of their optical activities clarified their chiralities: Dab(5L), Thr(3L), Ser(1D) and Phe(1D). The constituent fatty acid was identified with anteisononanoic acid by gas chromatography and mass spectrometry. By the action of polymyxin acylase, deacyl polymyxin S was obtained. Successive EDMAN degradation reaction on deacyl polymyxin S revealed the amino acid sequence. Further evidence for the structure of polymyxin S1 was obtained by partial acid hydrolysis on tetra-(DNP)-polymyxin S1.
Safe and Efficient Off-Policy Reinforcement Learning (2016)

In this work, we take a fresh look at some old and new algorithms for off-policy, return-based reinforcement learning. Expressing these in a common form, we derive a novel algorithm, Retrace($λ$), with three desired properties: (1) it has low variance; (2) it safely uses samples collected from any behaviour policy, whatever its degree of "off-policyness"; and (3) it is efficient as it makes the best use of samples collected from near on-policy behaviour policies. We analyze the contractive nature of the related operator under both off-policy policy evaluation and control settings and derive online sample-based algorithms. We believe this is the first return-based off-policy control algorithm converging a.s. to $Q^*$ without the GLIE assumption (Greedy in the Limit with Infinite Exploration). As a corollary, we prove the convergence of Watkins' Q($λ$), which was an open problem since 1989. We illustrate the benefits of Retrace($λ$) on a standard suite of Atari 2600 games.
Intramuscular ketamine in acute depression: A report on two cases (2013)

It takes about 2 weeks for the onset of antidepressant action of drugs while electroconvulsive therapy though faster, is a cumbersome procedure requiring an anaesthetist and at least a minor operation theatre. Recent studies have shown that Ketamine, when given to severely depressed patients in the dose of 0.5 mg/kg as a slow intravenous infusion over 40 minutes, brought about acute relief from depression and amelioration of suicidal risk within a few hours. The improvement, however, was transient and lasted for up to a week but could be sustained by further weekly or biweekly injections. As the dose of ketamine administered was found to be safe, it was now tried in the intramuscular route in two severely depressed patients with similar rapid improvement. The cases are reported here which pave way for an easier mode of treating acute depression.
Cellular proteins that associate with the middle and small T antigens of polyomavirus (1988)

We have used two-dimensional gel electrophoresis to analyze in more detail the cellular proteins which associate with the middle and small tumor antigens (MT and ST, respectively) of polyomavirus. Proteins with molecular masses of 27, 29, 36, 51, 61, 63, and 85 kilodaltons (kDa) that specifically coimmunoprecipitated with MT were identified on these gels. The 36-, 51-, 61-, 63-, and 85-kDa proteins are probably the same as the proteins of similar sizes previously reported by a number of groups, whereas the 27- and 29-kDa proteins represent proteins that are heretofore undescribed. The 27- and 29-kDa proteins were abundant cellular proteins, whereas the others were minor cellular constituents. The association of each of these proteins with MT was sensitive to one or more mutations in MT that rendered it transformation defective. The association of the 85-kDa protein was the most sensitive indicator of the transformation competence of MT mutants. In addition, the 85-kDa protein was the only associated protein whose association with MT changed consistently in parallel with MT-associated phosphatidylinositol kinase activity. Furthermore, the fraction of the 85-kDa protein which was found associated with the MT complex contained 15 to 20% of its phosphate content on tyrosine. The 36- and 63-kDa proteins complexed with both polyomavirus MT and ST and comigrated on two-dimensional gels with two simian virus 40 ST-associated proteins originally described by Rundell and coworkers (K. Rundell, E. O. Major, and M. Lampert, J. Virol. 37:1090-1093, 1981). None of the other MT-associated proteins associated significantly with ST.
Prognostic Factors for Long-Term Survival after Glioblastoma (2008)

Long-term survivors of glioblastoma (GB) are rare. Several variables besides tumor size and location determine a patient's survival chances: age at diagnosis, where younger patients often receive more aggressive treatment that is multimodal; functional status, which has a significant negative correlation with age; and histologic and genetic markers.
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 (2010)

The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.
Retraction dynamics of aqueous drops upon impact on non-wetting surfaces (2005)

We study the impact and subsequent retraction of liquid droplets upon high-speed impact on hydrophobic surfaces. Extensive experiments show that the drop retraction rate is a material constant and does not depend on the impact velocity. We show that on increasing the Ohnesorge number, $\Oh\,{=}\,\eta/\sqrt{\rho R_{\rm I} \gamma}$ , the retraction, i.e. dewetting, dynamics crosses from a capillary-inertial regime to a capillary-viscous regime. We rationalize the experimental observations by a simple but robust semi-quantitative model for the solid-liquid contact line dynamics inspired by the standard theories for thin-film dewetting.
SurfaceSlide: A Multitouch Digital Pathology Platform (2012)

SurfaceSlide is intuitive, fast and easy to use. SurfaceSlide represents the most direct, effective and intimate human-digital slide interaction experience. It is expected that SurfaceSlide will significantly enhance digital pathology tools and applications in education and clinical practice.