gebhart/patrepeval huggingface dataset:
The Magnitude of Basset Forces in Unsteady Multiphase Flow Computations (1992)

The equation of motion of a small spherical particle moving in a fluid is solved numerically with the radius of the sphere and the ratio of fluid to particle densities being parameters. The Basset force term is computed and compared to the total force on the particle for the case of turbulent flow in a duct. It is found that the Basset force may be neglected in the equation of motion of the particle only when the fluid to particle density ratio is very high and the particle diameter is greater than 1 μm. A dimensional analysis is also performed for the case when the particle size and the characteristic flow dimension are of the same order of magnitude. In the latter case, it is deduced that the Basset force is significant whenever the flow Reynolds number is greater than one.
[Bowen disease treated with scanned pulsed high energy CO2 laser. Follow-up of 6 cases]. (2001)

This new treatment has comparable efficacy to other treatments. It can be applied to extensive lesions without sequelae except for the risk of residual hypopigmentation.
Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases (2017)

Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and blocking its activity has been shown to limit the metastatic potential of various cancers. The small-molecules phenylhydrazine and β-aminopropionitrile are known to inhibit lysyl oxidase; however, issues of stability, toxicity, and poorly defined mechanisms limit their potential use in medical applications. The experiments presented herein evaluate three other families of hydrazine-derived compounds - hydrazides, alkyl hydrazines, and semicarbazides - as irreversible inhibitors of lysyl oxidase including determining the kinetic parameters and comparing the inhibition selectivities for lysyl oxidase against the topaquinone-containing diamine oxidase from lentil seedlings. The results suggest that the hydrazide group may be a useful core functionality that can be developed into potent and selective inhibitors of lysyl oxidase and eventually find application in cancer metastasis research.
Dense Passivating Poly(ethylene glycol) Films on Indium Tin Oxide Substrates (2007)

We describe the formation and characterization of surface-passivating poly(ethylene glycol) (PEG) films on indium tin oxide (ITO) glass substrates. PEG chains with a molecular weight of 2000 and 5000 D were covalently attached to the substrates in a systematic approach using different coupling schemes. The coupling strategies included the direct grafting with PEG-silane, PEG-methacrylate, and PEG-bis(amine), as well as the two-step functionalization with aldehyde-bearing silane films and subsequent coupling with PEG-bis(amine). Elemental analysis by X-ray photoelectron spectroscopy (XPS) confirmed the successful surface modification, and XPS and ellipsometry provided values for film thicknesses. XPS and ellipsometry thickness values were almost identical for PEG-silane films but differed by up to 400% for the other PEG layers, suggesting a homogeneous layer for PEG-silane but an inhomogeneous distribution for other PEG coatings on the molecularly rough ITO substrates. Atomic force microscopy (AFM) and water contact angle goniometry confirmed the different degrees of surface homogeneity of the polymer films, with PEG-silane reducing the AFM rms surface roughness by 50% and the water contact angle hysteresis by 75% compared to uncoated ITO. The ability of the PEG layers to passivate the substrate against the nonspecific adsorption of biopolymers was tested using fluorescence-labeled immunoglobulin G and DNA oligonucleotides in combination with fluorescence microscopy. The results indicate a positive relationship between film density and homogeneity on one hand and the ability to passivate against biopolymer adhesion on the other hand. The most homogeneous layers prepared with PEG-silane reduced the nonspecific adsorption of fluorescence-labeled DNA by a factor of 300 compared to uncoated ITO. In addition, the study finds that the ratio of film thicknesses derived by ellipsometry and XPS is a useful parameter to quantify the structural integrity of PEG layers on molecularly rough ITO surfaces. The findings may be applied to characterize PEG or other polymeric films on similarly coarse substrates.
Prostaglandins and ulcer healing. (2005)

Exogenous prostaglandins (PG) applied in small gastroprotective doses fail to affect healing of gastro-duodenal ulcers but accelerate the healing when used in larger gastric inhibitory doses that appear to enhance COX-2 expression and PGE(2) generation in the ulcer area. COX-1 and COX-inhibitors delay ulcer healing, particularly when both COX isoforms are suppressed such e.g. by indomethacin. Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2). Proton pump inhibitors (PPI) such as omeprazole and PGE analogs, accelerate ulcer healing mainly due to potent inhibition of gastric acid secretion, but they also augment the COX-2 expression and enzyme activity in the ulcerated mucosa. Endogenous PG generated at ulcer margin appear to be involved in ulcer healing promoted by growth factors and gut hormones such as gastrin or CCK and melatonin acting, at least in part, through increase of induction of COX-2 and local release of PGE(2) in the ulcer area. The ulcer healing activity of growth factors (e.g. EGF, TGF alpha, HGF) and certain gut hormones (gastrin, CCK) as well as melatonin, can be attenuated by treatment with COX-1 or COX-2 inhibitors which suppress the release of PGE(2) but enhance the expression of COX-2. It is concluded that endogenous PG originating mainly from upregulated COX-2 at the ulcer margin play crucial role in ulcer healing by exogenous PG, PPI, growth factors, gut hormones and melatonin, while COX-1 and COX-2 inhibitors delay ulcer healing by suppressing PG generation, and increasing COX-2 expression in the ulcer area.
Neutrophil Migration across Tight Junctions Is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils (2005)

Neutrophil (polymorphonuclear leukocytes [PMN]) transepithelial migration during inflammatory episodes involves a complex series of adhesive interactions and signaling events. Previous studies have shown that key adhesive interactions between leukocyte CD11b/CD18 and basally expressed fucosylated glycoproteins followed by binding to desmosomal-associated JAM-C are key elements of the transmigration response. Here we provide the first evidence that PMN-expressed junctional adhesion molecule-like protein (JAML) regulates transmigration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR). Experiments with a JAML fusion protein revealed specific binding of JAML to epithelial CAR expressed at tight junctions in T84 cell monolayers and normal human colonic mucosa. Furthermore, JAML-CAR binding is mediated via the membrane distal immunoglobulin (Ig) loop of CAR and the membrane proximal Ig loop of JAML. PMN bound to immobilized CAR but not JAML in a divalent cation-independent manner. Lastly, in assays of PMN transepithelial migration, JAML/CAR fusion proteins and their antibodies significantly inhibited transmigration in a specific manner. Taken together, these results indicate that JAML and CAR are a novel pair of adhesion molecules that play an important role in modulating PMN migration cross epithelial tight junctions. These findings add a new element to a multistep model of PMN transepithelial migration and may provide new targets for anti-inflammatory therapies.
Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles (2012)

The use of nanoparticles in medicine (nanomedicine) has recently become an intensely studied field. Nanoparticles carrying drugs and imaging agents have already reached the clinic, but they are essentially passive delivery vehicles, not what are referred to as "smart" nanoparticles. An important function to add to make nanoparticles smarter is active homing to the target tissue. It makes nanoparticles accumulate in the target tissue at higher concentrations than would be the case without this feature, increasing therapeutic efficacy and reducing side effects. This review discusses the recent developments in the nanoparticle targeting field with emphasis on peptides that home to vascular "zip codes" in target tissues and provide a tissue- and cell-penetrating function.
Management of Early Groin Vascular Bypass Graft Infections With Sartorius and Rectus Femoris Flaps (2003)

Groin infections adjacent to vascular bypass grafts continue to be a source of morbidity. The authors reviewed retrospectively 9 consecutive patients with early localized groin infections treated at their institution with sartorius or rectus femoris muscle flaps between 1998 and 2002. All wounds were initially opened and drained. Wounds with necrotic tissue were treated with serial surgical debridements, with a vacuum-assisted closure device, or with wet-to-dry dressing changes. Two bypass grafts were excised and replaced in the presence of marked exposure or pseudoaneurysm. Small wounds were closed with a turnover sartorius flap and larger wounds were closed with either a muscle or musculocutaneous rectus femoris flap. Groin wounds healed in all patients without subsequent graft exposure, rupture, or pseudoaneurysm. Local wound therapy with staged debridement and muscle flaps is effective for most early localized graft infections.
A Review of Phased Array Steering for Narrow-Band Electrooptical Systems (2009)

Nonmechanical steering of optical beams will enable revolutionary systems with random access pointing, similar to microwave radar phased arrays. An early approach was birefringent liquid crystals writing a sawtooth phase profile in one polarization, using 2pi resets. Liquid crystals were used because of high birefringence. Fringing fields associated with voltage control required to implement the 2pi resets have limited the efficiency and steering angle of this beam steering approach. Because of steering angle limitations, this conventional liquid crystal steering approach is usually combined with a large angle step-steering approach. Volume holograms, birefringent prisms or sawtooth-profile birefringent phase gratings, and circular-type polarization gratings are the large angle step steering approaches that will be reviewed in this paper. Alternate steering approaches to the combined liquid crystal and step-steering approach exist. Microelectromechanical system mirrors, lenslet arrays, electrowetting, and a variable birefringent grating approach will be reviewed and compared against the conventional liquid crystal and step-steering approaches. Step-steering approaches can also be combined with these approaches. Multiple nonmechanical steering approaches are developing that will allow high-efficiency steering, excellent steering accuracy, and wide fields of view.
Differential regulation of the insulin‐like growth factor II mRNA‐binding protein genes by architectural transcription factor HMGA2 (2004)

The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.
End-to-End Multi-Speaker Speech Recognition (2018)

Current advances in deep learning have resulted in a convergence of methods across a wide range of tasks, opening the door for tighter integration of modules that were previously developed and optimized in isolation. Recent ground-breaking works have produced end-to-end deep network methods for both speech separation and end-to-end automatic speech recognition (ASR). Speech separation methods such as deep clustering address the challenging cocktail-party problem of distinguishing multiple simultaneous speech signals. This is an enabling technology for real-world human machine interaction (HMI). However, speech separation requires ASR to interpret the speech for any HMI task. Likewise, ASR requires speech separation to work in an unconstrained environment. Although these two components can be trained in isolation and connected after the fact, this paradigm is likely to be sub-optimal, since it relies on artificially mixed data. In this paper, we develop the first fully end-to-end, jointly trained deep learning system for separation and recognition of overlapping speech signals. The joint training framework synergistically adapts the separation and recognition to each other. As an additional benefit, it enables training on more realistic data that contains only mixed signals and their transcriptions, and thus is suited to large scale training on existing transcribed data.
The Effect of a Protein Kinase C Inhibitor, H-7, on Human Neutrophil Oxidative Burst and Degranulation (1987)

The role of C-kinase in the activation of human polymorphonuclear leukocytes has been examined using H-7, a recently described C-kinase inhibitor. We found that H-7 will inhibit PMN superoxide anion release in response to the tumor promotor phorbol myristate acetate and the calcium ionophore A23187. In contrast, no inhibition by H-7 was seen for PMN superoxide release stimulated by the chemotactic peptide FMLP. H-7 did not inhibit PMN NADPH oxidase activity or PMN degranulation by any stimulant, but it reversed a phorbol ester-induced inhibition of granule release by FMLP. The results show that H-7 differentially affects the PMN functional events of secretion and superoxide release and suggests that an H-7 inhibitable C-kinase is not involved in chemotactic peptide induced activation of PMN and may not regulate stimulus induced PMN degranulation.
Glucocorticoids Suppress Tumor Lymphangiogenesis of Prostate Cancer Cells (2006)

Glucocorticoids suppressed tumor-associated lymphangiogenesis by down-regulating VEGF-C through glucocorticoid receptor in androgen-independent prostate cancer cells in vivo.
Acute graft versus host disease (2007)

Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. About 35%-50% of hematopoietic stem cell transplant (HSCT) recipients will develop acute GVHD. The exact risk is dependent on the stem cell source, age of the patient, conditioning, and GVHD prophylaxis used. Given the number of transplants performed, we can expect about 5500 patients/year to develop acute GVHD. Patients can have involvement of three organs: skin (rash/dermatitis), liver (hepatitis/jaundice), and gastrointestinal tract (abdominal pain/diarrhea). One or more organs may be involved. GVHD is a clinical diagnosis that may be supported with appropriate biopsies. The reason to pursue a tissue biopsy is to help differentiate from other diagnoses which may mimic GVHD, such as viral infection (hepatitis, colitis) or drug reaction (causing skin rash). Acute GVHD is staged and graded (grade 0-IV) by the number and extent of organ involvement. Patients with grade III/IV acute GVHD tend to have a poor outcome. Generally the patient is treated by optimizing their immunosuppression and adding methylprednisolone. About 50% of patients will have a solid response to methylprednisolone. If patients progress after 3 days or are not improved after 7 days, they will get salvage (second-line) immunosuppressive therapy for which there is currently no standard-of-care. Well-organized clinical trials are imperative to better define second-line therapies for this disease. Additional management issues are attention to wound infections in skin GVHD and fluid/nutrition management in gastrointestinal GVHD. About 50% of patients with acute GVHD will eventually have manifestations of chronic GVHD.
Andean elevation control on tropical Pacific climate and ENSO (2014)

Late Cenozoic marine proxy data record a long-term transition in the tropical Pacific from El Niño-like conditions with reduced zonal sea surface temperature (SST) gradient, deepened thermocline, and reduced upwelling in the eastern equatorial Pacific (EEP) to conditions similar to modern. This transition coincides with kilometer-scale uplift of the central Andes. To understand whether the rise of the Andes contributed to tropical Pacific climate evolution, we performed experiments with the National Center for Atmospheric Research's Community Climate System Model version 4 to quantify changes in tropical Pacific climate and El Niño–Southern Oscillation as a function of Andean elevations. Our results demonstrate that uplift increases the equatorial east-west SST gradient and Walker circulation. The rise of the Andes from 1 to 3 km increases the SST gradient by 0.8°C and Walker circulation by 60% due to strengthened radiative cooling by enhanced low-cloud formation in the EEP. This cooling effect is largest in the southeastern tropical Pacific and accounts for about one half of the reconstructed SST cooling along the Peru coast. The uplift also strengthens upwelling north of the EEP, consistent with documented increases in biological productivity in this region, and decreases the frequency of El Niño–Southern Oscillation and the number of strong El Niño events. Simulated responses to Andean uplift are generally consistent with the late Cenozoic proxy records, but too small in magnitude. Taken together, our results indicate that Andean uplift was likely one of the multiple factors that contributed to the long-term evolution of both the mean climate state and the interannual variability in the tropical Pacific.
[MiR-192 confers cisplatin resistance by targeting Bim in lung cancer]. (2014)

Our data suggested that miR-192 induced Cisplatin-resistance and inhibited cell apoptosis in lung cancer via negative targeting Bim expression.
Variations in the perception of urban forest recreation sites (1983)

Abstract This study demonstrates a procedure for detecting variations in the perceived quality of urban forest recreation sites. Observers viewed photographs of a wide range of sites and rated the perceived quality of each. Factor analysis of the interrater correlation matrix revealed two predominant groups of individuals, one favoring natural‐appearing forest settings and the other preferring well‐developed city parks. Individuals who have spent most of their lives in urban areas were more likely to prefer developed parks, and individuals who have spent most of their lives in suburban or rural areas were more likely to prefer natural forests.
SOLVING NONLINEAR EQUATIONS BY PERTURBATION TECHNIQUE AND LAGRANGE EXPANSION (2010)

In this paper we introduce the perturbation technique and Lagrange expansion for solving nonlinear algebraic equations. Some examples are presented to illustrate the simplicity and e- ciency of the proposed algorithm.
Logistic Regression Using the SAS System : Theory and Application (1999)

From the Publisher:
If you are a researcher or student with experience in multiple linear regression and want to learn about logistic regression, this book is for you! Informal and nontechnical, this book both explains the theory behind logistic regression and looks at all the practical details involved in its implementation using SAS. Several social science real-world examples are included in full detail. This book also explains the differences and similarities among the many generalizations of the logistic regression model. The following topics are covered: binary logit analysis, logit analysis of contingency tables, multinomial logit analysis, ordered logit analysis, discrete-choice analysis with the PHREG procedure, and Poisson regression. Other highlights include discussions on how to use the GENMOD procedure to do loglinear analysis and GEE estimation for longitudinal binary data. Only basic knowledge of the SAS DATA step is assumed. 
Supports releases 6.12 and higher of SAS software.
Author Biography: Paul D. Allison Paul D. Allison is a Professor of Sociology and Epidemiology at the University of Pennsylvaniawhere he teaches graduate courses in survival analysis and categorical data analysis. Every summer he teaches a five-day workshop about logistic regression that is attended by researchers from around the United States and Canada. Besides his numerous statistical papers, he has also published extensively on the subject of scientists' careers.
Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. (1995)

Autoantibodies from many patients with systemic lupus erythematosus bind the Sm autoantigen B/B' polypeptide. The binding of serial serum specimens to the 233 overlapping octapeptides of Sm B/B' have shown that of the B/B'-derived octapeptides, PPPGMRPP and PPPGIRGP are early targets of the autoimmune response in some lupus patients. Rabbits immunized with PPPGMRPP and PPPGIRGP develop antibodies which not only bind these octapeptides, but also subsequently bind many other octapeptides of Sm B/B'. Eventually, the rabbits immunized with one octapeptide develop autoantibodies that bind other spliceosomal proteins including D, 70K, A, and C. Any mechanisms that operate to maintain tolerance or anergy for the spliceosome are thus overcome. Features considered typical of human systemic lupus erythematosus are also found in these peptide-immunized animals, such as antinuclear antibodies, anti-Sm precipitins, anti-double-stranded DNA, thrombocytopenia, seizures, and proteinuria. This disease model provides access to a mechanism for the development of humoral autoimmunity and may provide a basis to explain the immunopathogenesis of lupus in humans.