gebhart/patrepeval huggingface dataset:
Fiber-based polarization-sensitive optical coherence tomography (2000)

In optical coherence tomography (OCT), mapping the polarization state of the reflected light provides additional information about tissue structure and prevents polarization induced image artifacts. As OCT is increasingly used with subjects in vivo, demands on the imaging system and data acquisition rates increase. We present a fiber- based, rapid scanning, polarization-sensitive OCT system capable of acquiring image data at the rate of 20K pixel/s. To achieve high scan rates, a rapid-scanning optical delay line generates a reference arm group delay while a waveguide-based phase modulator generates a suitable, stable carrier frequency for the detection electronics. Group delays up to 4.5 mm are obtained at frequencies approaching 1 kHz. The group delay and carrier frequency are independently controllable, which has the advantage that either the lateral or the axial scan direction may be chosen as the fast axis. Tomographic images corresponding to the intensity and polarization components of the Stokes vector describing the back scattered light are obtained by analyzing the interference signals from two orthogonally polarized channels in the detection arm for each of four polarization states incident on the sample. Polarization images of human skin taken in vivo are shown.
Direct Observation of an Acyl Nitroso Species in Solution by Time-Resolved IR Spectrocopy (2003)

Benzoyl nitroside (5) was generated in solution by laser photolysis of 3,5-diphenyl-1,2,4-oxadiazole-4-oxide (4) and studied by time-resolved infrared spectroscopy. The second-order rate constants for reaction of 5 with diethylamine and 1,3-cyclohexadiene were determined to be (1.3 +/- 0.5) x 10(5) M(-1) s(-1) and (6.0 +/- 0.5) x 10(3) M(-1) s(-1), respectively. The formation of nitroxyl (HNO), a product of the reaction of 5 with diethylamine, was also observed.
Fourier transform infrared external reflection study of molecular orientation in spontaneously adsorbed layers on low-absorption substrates (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFourier transform infrared external reflection study of molecular orientation in spontaneously adsorbed layers on low-absorption substratesJ. A. Mielczarski and R. H. YoonCite this: J. Phys. Chem. 1989, 93, 5, 2034–2038Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/j100342a064https://doi.org/10.1021/j100342a064research-articleACS PublicationsRequest reuse permissionsArticle Views362Altmetric-Citations113LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Armchair Economist: Economics and Everyday Life. (1994)

Why does popcorn cost so much at the movies? When does it make sense not to recycle? Why are laws against polygamy detrimental to women? Steven E. Landsburg examines everything from taxes, unemployment and illiteracy to the mating game, the death penalty and environmentalism to solve the puzzling questions that occur in daily living. Both controversial and humorous, The Armchair Economist demystifies the economics of everyday behaviour, and shows how the laws of economics can reveal themselves in surprising ways. Put your convictions to the test with The Armchair Economist.
Predictors of Responsiveness to Bisphosphonate Treatment in Patients with Complex Regional Pain Syndrome Type I: A Retrospective Chart Analysis (2016)

Early disease, fracture as a predisposing event, and "warm" disease subtype are predictors of responsiveness to bisphosphonate treatment in patients with CRPS-I.
New insights on the biology of myelin basic protein gene: The neural-Immune connection (2000)

In the past 6 years, our conception of the major myelin protein genes has begun to change significantly because of recent findings documenting the existence of new exons encoding other products of these genes. A decade ago the myelin basic protein (MBP) and proteolipid protein (PLP) genes were thought to be expressed solely in myelin-forming cells, and their products were thought to be structural components of myelin. Since then, abundant evidence has been gathered identifying the presence of products of these genes in nonmyelinating cell types including both the immune and the nervous systems. Furthermore, within the nervous system, products of these genes have been identified in neurons and embryonic cells, clearly indicating that these myelin protein genes have additional functions in a number of cell types that are unrelated to myelination. In this brief communication, we review the recent literature that has resulted in this revision of our understanding of the MBP gene structure, products and expression.
Studies on the embryotoxic and teratogenic effects of Tołpa Peat Preparation. (1993)

Neither embryotoxic nor teratogenic effects were observed in hamsters and rats after administration of Tołpa Peat Preparation (TPP) in doses of 5 and 50 mg/kg daily. Some maternal toxicity in rats and some embryotoxic effect in hamsters were recorded after the highest dose of TPP (250 mg/kg daily).
Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus+ Hodgkin's Disease (2004)

Epstein Barr virus (EBV)+ Hodgkin's disease (HD) expresses clearly identified tumor antigens derived from the virus and could, in principle, be a target for adoptive immunotherapy with viral antigen-specific T cells. However, like most tumor-associated antigens in immunocompetent hosts, these potential targets are only weakly immunogenic, consisting primarily of the latent membrane protein (LMP)1 and LMP2 antigens. Moreover, Hodgkin tumors possess a range of tumor evasion strategies. Therefore, the likely value of immunotherapy with EBV-specific cytotoxic effector cells has been questioned. We have now used a combination of gene marking, tetramer, and functional analyses to track the fate and assess the activity of EBV cytotoxic T lymphocyte (CTL) lines administered to 14 patients treated for relapsed EBV+ HD. Gene marking studies showed that infused effector cells could further expand by several logs in vivo, contribute to the memory pool (persisting up to 12 mo), and traffic to tumor sites. Tetramer and functional analyses showed that T cells reactive with the tumor-associated antigen LMP2 were present in the infused lines, expanded in peripheral blood after infusion, and also entered tumor. Viral load decreased, demonstrating the biologic activity of the infused CTLs. Clinically, EBV CTLs were well tolerated, could control type B symptoms (fever, night sweats, and weight loss), and had antitumor activity. After CTL infusion, five patients were in complete remission at up to 40 mo, two of whom had clearly measurable tumor at the time of treatment. One additional patient had a partial response, and five had stable disease. The performance and fate of these human tumor antigen-specific T cells in vivo suggests that they might be of value for the treatment of EBV+ Hodgkin lymphoma.
Design of Glycoconjugate Vaccines against Invasive African Salmonella enterica Serovar Typhimurium (2014)

Nontyphoidal salmonellae, particularly Salmonella enterica serovar Typhimurium, are a major cause of invasive disease in Africa, affecting mainly young children and HIV-infected individuals. Glycoconjugate vaccines provide a safe and reliable strategy against invasive polysaccharide-encapsulated pathogens, and lipopolysaccharide (LPS) is a target of protective immune responses. With the aim of designing an effective vaccine against S. Typhimurium, we have synthesized different glycoconjugates, by linking O-antigen and core sugars (OAg) of LPS to the nontoxic mutant of diphtheria toxin (CRM(197)). The OAg-CRM(197) conjugates varied in (i) OAg source, with three S. Typhimurium strains used for OAg extraction, producing OAg with differences in structural specificities, (ii) OAg chain length, and (iii) OAg/CRM(197) ratio. All glycoconjugates were compared for immunogenicity and ability to induce serum bactericidal activity in mice. In vivo enhancement of bacterial clearance was assessed for a selected S. Typhimurium glycoconjugate by challenge with live Salmonella. We found that the largest anti-OAg antibody responses were elicited by (i) vaccines synthesized from OAg with the highest glucosylation levels, (ii) OAg composed of mixed- or medium-molecular-weight populations, and (iii) a lower OAg/CRM(197) ratio. In addition, we found that bactericidal activity can be influenced by S. Typhimurium OAg strain, most likely as a result of differences in OAg O-acetylation and glucosylation. Finally, we confirmed that mice immunized with the selected OAg-conjugate were protected against S. Typhimurium colonization of the spleen and liver. In conclusion, our findings indicate that differences in the design of OAg-based glycoconjugate vaccines against invasive African S. Typhimurium can have profound effects on immunogenicity and therefore optimal vaccine design requires careful consideration.
Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes (2001)

Recent data indicate that sustained elevations in plasma insulin suppress the mRNA for IRS-2, a component of the insulin signaling pathway in liver, and that this deficiency contributes to hepatic insulin resistance and inappropriate gluconeogenesis. Here, we use nuclear run-on assays to show that insulin inhibits transcription of the IRS-2 gene in the livers of intact rats. Insulin also inhibited transcription of a reporter gene driven by the human IRS-2 promoter that was transfected into freshly isolated rat hepatocytes. The human promoter contains a heptanucleotide sequence, TGTTTTG, that is identical to the insulin response element (IRE) identified previously in the promoters of insulin-repressed genes. Single base pair substitutions in this IRE decreased transcription of the IRS-2-driven reporter in the absence of insulin and abolished insulin-mediated repression. We conclude that insulin represses transcription of the IRS-2 gene by blocking the action of a positive factor that binds to the IRE. Sustained repression of IRS-2, as occurs in chronic hyperinsulinemia, contributes to hepatic insulin resistance and accelerates the development of the diabetic state.
Cystic Fibrosis Sputum DNA Has NETosis Characteristics and Neutrophil Extracellular Trap Release Is Regulated by Macrophage Migration-Inhibitory Factor (2014)

Neutrophils are the main proinflammatory cell type in chronically infected lungs of cystic fibrosis (CF) patients; however, they fail to effectively clear the colonizing pathogens. Here, we investigated the molecular composition of non-mucoid and mucoid Pseudomonas aeruginosa-induced neutrophil extracellular traps (NETs) in vitro and compared them to the DNA-protein complexes present in the CF sputum. The protein composition of P. aeruginosa-induced NET fragments revealed that irrespective of the inducing stimuli, NET fragments were decorated with a conserved set of proteins. The DNA-protein complexes derived from CF sputum were consistent with NETosis and shared a similar protein signature, suggesting that the majority of the extracellular DNA was NET derived. The ability of polymorphonuclear leukocytes to produce NETs in response to P. aeruginosa was driven by macrophage migration-inhibitory factor (MIF) by promoting mitogen-activated protein kinase. Analysis of 132 CF patient samples revealed that elevated MIF protein levels correlated with poorer lung function. We suggest that targeting MIF by small molecular inhibitors might reduce the presence of extracellular DNA and serve as an adjunct to the use of antimicrobial drugs that could ultimately reduce bacterial fitness in the lungs during the later stages of CF disease.
Thin, Continuous, and Conformal Copper Films by Reduction of Atomic Layer Deposited Copper Nitride (2006)

Abstract Thin and continuous copper films serve as seed layers for electrodeposition of interconnects in microelectronic devices. Gaps in the continuity of these Cu films must be avoided, because they can generate voids that later lead to failure of the devices. It is difficult to sputter completely continuous copper‐seed layers into the increasingly narrow trenches and holes in modern interconnects. Here we report a method for producing thin, completely continuous, and highly conductive copper films conformally inside very narrow holes with aspect ratios of over 40:1. The first step in our process is atomic layer deposition (ALD) of copper(I) nitride, Cu 3 N, by the alternating reactions of copper(I) N , N′ ‐di‐ sec ‐butylacetamidinate vapor and ammonia on surfaces heated to approximately 160 °C. At this temperature, Cu 3 N is thermally stable, but is readily reduced to copper metal by exposure to molecular hydrogen gas (H 2 ). Copper layers as thin as 0.8 nm (about 3 monolayers) are electrically continuous and show the electrical resistivity predicted by a grain‐boundary‐scattering model for continuous films of that thickness. 3 nm thick copper films on 2 nm of ruthenium have a sheet resistance of less than 50 Ω/□, a value low enough to serve as seed layers for advanced electroplating techniques.
Location Assisted Coding (LAC) (2015)

As the number of wireless devices grows, the increasing demand for the shared radio frequency (RF) spectrum becomes a critical problem. Unlike wired communications in which, theoretically, more fibers can be used to accommodate the increasing bandwidth demand, wireless spectrum cannot be arbitrarily increased due to the fundamental limitations imposed by the physical laws. On the other hand, recent advances in free space optical (FSO) technologies promise a complementary approach to increase wireless capacity. However, high-speed FSO technologies are currently confined to short distance transmissions, resulting in limited mobility. In this paper, we briefly describe WiFO, a hybrid WiFi-FSO network for Gbps wireless local area network (WLAN) femtocells that can provide up to one Gbps per user while maintaining seamless mobility. While typical RF femtocells are non-overlapped to minimize inter-cell interference, there are advantages of using overlapped femtocells to increase mobility and throughput when the number of users is small. That said, the primary contribution of this paper will be a novel location assisted coding (LAC) technique used in the WiFO network that aims to increase throughput and reduce interference for multiple users in a dense array of femtocells. Both theoretical analysis and numerical experiments show orders of magnitude increase in throughput using LAC over basic codes.
<title>Holographic stereograms as discrete imaging systems</title> (1994)

Unlike holograms of real objects, holographic stereograms consist of information recorded from a relatively small number of discrete viewpoints. As discrete imaging systems, holographic stereograms are susceptible to aliasing artifacts caused by insufficient or improper sampling. A characterization of sampling-related image artifacts in holographic stereograms is presented. Constraints on image extent and resolution imposed by sampling are outlined. Methods of reducing or eliminating aliasing artifacts in both photographically-recorded and computer-generated holographic stereogram images are described. Results of this analysis can be generalized to describe other autostereoscopic displays.
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death (1996)

Studies on mice deficient in nuclear factor kappa B (NF-kappaB) subunits have shown that this transcription factor is important for lymphocyte responses to antigens and cytokine-inducible gene expression. In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha)-dependent genes. Treatment of RelA-deficient (RelA-/-) mouse fibroblasts and macrophages with TNF-alpha resulted in a significant reduction in viability, whereas RelA+/+ cells were unaffected. Cytotoxicity to both cell types was mediated by TNF receptor 1. Reintroduction of RelA into RelA-/- fibroblasts resulted in enhanced survival, demonstrating that the presence of RelA is required for protection from TNF-alpha. These results have implications for the treatment of inflammatory and proliferative diseases.
Analyzing and Improving the Image Quality of StyleGAN (2020)

The style-based GAN architecture (StyleGAN) yields state-of-the-art results in data-driven unconditional generative image modeling. We expose and analyze several of its characteristic artifacts, and propose changes in both model architecture and training methods to address them. In particular, we redesign the generator normalization, revisit progressive growing, and regularize the generator to encourage good conditioning in the mapping from latent codes to images. In addition to improving image quality, this path length regularizer yields the additional benefit that the generator becomes significantly easier to invert. This makes it possible to reliably attribute a generated image to a particular network. We furthermore visualize how well the generator utilizes its output resolution, and identify a capacity problem, motivating us to train larger models for additional quality improvements. Overall, our improved model redefines the state of the art in unconditional image modeling, both in terms of existing distribution quality metrics as well as perceived image quality.
Induction of a Regulatory T Cell Type 1 Response Reduces the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice (2003)

Tr1-type regulatory immune response reduces the development of experimental atherosclerosis.
Regulation of sialic acid metabolism in Escherichia coli: role of N-acylneuraminate pyruvate-lyase (1985)

In Escherichia coli, synthesis of sialic acid is not regulated by allosteric inhibition mediated by cytidine 5'-monophospho-N-acetylneuraminic acid (CMP-NeuNAc). Evidence for the lack of metabolic control by feedback inhibition was demonstrated by measuring the intracellular level of sialic acid and CMP-NeuNAc in mutants defective in sialic acid polymerization and in CMP-NeuNAc synthesis. Polymerization-defective mutants could not synthesize the polysialic acid capsule and accumulated ca. 25-fold more CMP-NeuNAc than the wild type. Mutants unable to activate sialic acid because of a defect in CMP-NeuNAc synthetase accumulated ca. sevenfold more sialic acid than the wild type. An additional threefold increase in sialic acid levels occurred when a mutation resulting in loss of N-acylneuraminate pyruvate-lysase (sialic acid aldolase) was introduced into the CMP-NeuNAc synthetase-deficient mutant. The aldolase mutation could not be introduced into the polymerization-defective mutant, suggesting that any further increase in the intracellular CMP-NeuNAc concentration was toxic. These results show that sialic acid aldolase can regulate the intracellular concentration of sialic acid and therefore the concentration of CMP-NeuNAc. We conclude that regulation of aldolase, mediated by sialic acid induction, is necessary not only for dissimilating sialic acid (E.R. Vimr and F. A. Troy, J. Bacteriol. 164:845-853, 1985) but also for modulating the level of metabolic intermediates in the sialic acid pathway. In agreement with this conclusion, an increase in the intracellular sialic acid concentration was correlated with an increase in aldolase activity. Direct evidence for the central role of aldolase in regulating the metabolic flux of sialic adid in E. coli was provided by the finding that exogenous radiolabeled sialic acid was specifically incorporated into sialyl polymer in aldolase-negative strain but not in the wild type.
Macromolecular and dendrimer-based magnetic resonance contrast agents (2010)

Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.
Relaxin Receptors - New Drug Targets for Multiple Disease States (2006)

Relaxin was discovered more than 75 years prior to the identification of the receptors that mediate its actions. There has been a slow emergence in understanding the role of relaxin, with it being denoted initially as a hormone of pregnancy due to its observed effects to relax pubic ligaments and soften the cervix of guinea pigs to facilitate parturition. However, many other physiological roles have been identified for relaxin, including cardiovascular and neuropeptide functions and an ability to induce the matrix metalloproteinases, so it is clear that relaxin is not exclusively a hormone of pregnancy but has a much wider role in vivo. The recent de-orphanisation of four receptors LGR7, LGR8, GPCR135 (SALPR) and GPCR142 (GPR100) that respond to and bind at least one of the three forms of relaxin identified to date, allows dissection of this system to determine the precise role of each receptor and enable the identification of new targets for treatment of numerous disease states. Relaxin has the potential to be useful for the treatment of scleroderma, fibrosis, in orthodontics and to facilitate embryo implantation in humans. Relaxin antagonists may act as contraceptives or prevent the development of breast cancer metastases. Recent research has added considerable knowledge to the signalling pathways activated by relaxin, which will aid our understanding of how relaxin produces its effects. The focus of this review is to bring together recent developments in the relaxin receptor field and to highlight their potential as drug targets.