gebhart/patrepeval huggingface dataset:
Computing ripple effect for software maintenance (2001)

Abstract Recent software maintenance models have included impact analysis and accounting for ripple effect as one of their stages. This paper describes and explains the reformulation of Yau and Collofello's ripple‐effect algorithm and its validity within the software‐maintenance process. Completely automatic computation of ripple effect has until now proved troublesome; we show how our approximation algorithm helps to overcome this. Our Ripple Effect and Stability Tool (REST) which uses our approximated algorithm to compute ripple effect for C programs, is described. Eleven C programs are used in an initial investigation into whether our approximated algorithm can replace Yau and Collofello's original algorithm for the purpose of automatic computation of ripple effect. The Pearson correlation coefficient for the two versions of the algorithm across the eleven programs shows a high correlation. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Out of "Dark Backrooms and Sheds" (2007)

Commitment to a single, inclusive education system has been the aspiration of reform in education in a democratic South Africa as articulated in White Paper 6: Special needs education: Building an inclusive education and training system (Department of Education, 2001, referred to hereafter as White Paper 6). Within a ‘barriers to learning’ approach to inclusive education, progress is being made with improved facilities and the implementation of AIDS awareness programmes. Managing the transition towards an inclusive education system has proved challenging in some areas, however, and the specific provision in policy documents directed towards children with disabilities is behind schedule. One component that is furthest behind in the proposed milestones is the implementation of the information and advocacy programme (Maher, 2007). This article discusses the need for the information and advocacy programme to be prioritized, and presents a model which weaves together an adaptation of Bronfenbrenner’s ecological model (Bronfenbrenner, 1979, 1989, 1993) and the tenets of human agency theory (Bandura, 2001; Bandura, Barbaranelli, Caprara, & Pastorelli, 1996; Bandura, Pastorelli, Barbaranelli, & Caprara, 1999; Carlson, 1997), which are central to decision-making, self-regulation and self-determination. This model provides a framework within which people can enact their democratic right in a wider sense than casting a political vote, potentially advancing their self-efficacy. The framework, furthermore, encourages people to begin to reposition themselves and to adjust their beliefs towards a more positive notion of the inclusion of children with special needs in regular education.
FOCUSING OF SYNTHETIC APERTURE ULTRA WIDEBAND DATA (1991)

This paper addresses the SAR focusing problem with special attcntion given to focusing an area in thenear-field of the synthetic aperture over a decade or more of bandwidth in a manner that preserves target rcsonance characteristics. An approximation is shown that reduces the computational load. An error analysis of the approximation shows quantitatively what conditions are required to guarantee that the depth of focus is adequate to prcscrve long-duration target resonance effects.
Emerging Roles of Carbohydrates and Glycomimetics in Anticancer Drug Design (2000)

Tumorigenesis is accompanied by marked changes in the expression and presentation of various macromolecules at the cell surface. These tumor-associated adjustments result from the differential expression of genes coding for the production or post-translational modifications of these macromolecules during transformation to a particular tumor phenotype. In turn, tumor cells acquire distinct biophysical properties which set them apart from their normal counterparts. Alterations of carbohydrate structures and their organization on the surface of neoplastic cells is a hallmark of the tumorigenic and, most notably, the metastatic phenotype. Carbohydrate-protein and carbohydrate-carbohydrate interactions are critical events in the progression, dissemination and invasion of cancer cells. Many cell-cell contacts and subsequent remodeling of the tumor microenvironment are mediated by cell-surface glycans. The discovery of agents that modulate these interactions or interfere with the processing of tumor associated oligosaccharides is a fervent area of research today. This review will highlight the current status of the use of carbohydrate-based compounds that are being evaluated as potential anticancer therapeutics. In addition, the use of structures based on glycopeptides and carbohydrate mimetics will also be discussed.
Management of Women with Cervicitis (2007)

In the past several years, the collective understanding of cervicitis has extended beyond the recognition of &lt;it&gt;Chlamydia trachomatis&lt;/it&gt; and &lt;it&gt;Neisseria gonorrhoeae&lt;/it&gt; as the prime etiologic suspects. &lt;it&gt;Trichomonas vaginalis&lt;/it&gt; and herpes simplex virus cause cervicitis, and both &lt;it&gt;Mycoplasma genitalium&lt;/it&gt; and bacterial vaginosis have emerged as new candidate etiologic agents or conditions. However, major gaps in our knowledge of this common condition remain. Putative etiologic agents have not been identified in many women with cervicitis. Moreover, cervicitis occurs in a relatively small proportion of women with chlamydia or gonorrhea. Finally, scant research has addressed the clinical response of nonchlamydial and nongonococcal cervicitis to antibiotic therapy, and there are no data on the benefit of sex partner treatment for such women. New research into the etiology, immunology, and natural history of this common condition is needed, especially in view of the well-established links between cervicitis and an increased risk of upper genital tract infection and human immunodeficiency virus type 1 acquisition.
A comparison of patellar tendon autograft and allograft used for anterior cruciate ligament reconstruction in the goat model (1993)

Similar-sized patellar tendon autografts and fresh-frozen allografts were used to reconstruct the anterior cruciate ligament of one knee in 40 female goats. Evaluations of the reconstructions and contralateral controls at the 6-week and 6-month postoperative periods included anterior-posterior translation, mechanical properties determined during tensile failure tests, measurement of cross-sectional area, histology, collagen fibril size and area distribution, and associated articular cartilage degenerative changes. Six months after anterior cruciate ligament reconstruction, the autografts demonstrated a smaller increase in anterior-posterior displacement, values of maximum force to failure two times greater, a significant increase in cross-sectional area, a more rapid loss of large-diameter collagen fibrils, and an increased density and number of small-diameter collagen fibrils compared to the allografts. Clinical significance. More surgeons are allowing their patients to return to running and sports 6 months after anterior cruciate ligament reconstruction. While the structural and material properties of autografts and allografts at time zero are similar, in the goat model during the first 6 months they differ. The allografts demonstrate a greater decrease in their implantation structural properties, a slower rate of biologic incorporation, and the prolonged presence of an inflammatory response. At 6 months the autograft demonstrates a more robust biologic response, improved stability, and increased strength to failure values.
Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon (1993)

An outer membrane protein of 50 kDa (OprK) was overproduced in a siderophore-deficient mutant of Pseudomonas aeruginosa capable of growth on iron-deficient minimal medium containing 2,2'-dipyridyl (0.5 mM). The expression of OprK in the mutant (strain K385) was associated with enhanced resistance to a number of antimicrobial agents, including ciprofloxacin, nalidixic acid, tetracycline, chloramphenicol, and streptonigrin. OprK was inducible in the parent strain by growth under severe iron limitation, as provided, for example, by the addition of dipyridyl or ZnSO4 to the growth medium. The gene encoding OprK (previously identified as ORFC) forms part of an operon composed of three genes (ORFABC) implicated in the secretion of the siderophore pyoverdine. Mutants defective in ORFA, ORFB, or ORFC exhibited enhanced susceptibility to tetracycline, chloramphenicol, ciprofloxacin, streptonigrin, and dipyridyl, consistent with a role for the ORFABC operon in multiple antibiotic resistance in P. aeruginosa. Sequence analysis of ORFC (oprK) revealed that its product is homologous to a class of outer membrane proteins involved in export. Similarly, the products of ORFA and ORFB exhibit homology to previously described bacterial export proteins located in the cytoplasmic membrane. These data suggest that ORFA-ORFB-oprK (ORFC)-dependent drug efflux contributes to multiple antibiotic resistance in P. aeruginosa. We propose, therefore, the designation mexAB (multiple efflux) for ORFAB.
Transpupillary Thermotherapy for Age-Related Macular Degeneration: Long-Pulse Photocoagulation, Apoptosis, and Heat Shock Proteins (2000)

To achieve a preselected temperature rise, TTT laser power must be increased or decreased in proportion to the diameter rather than the area of the laser spot. Clinical power settings should be adjusted for fundus pigmentation and media clarity because both of these factors affect absorbed retinal irradiance and thus retinal temperature rise. Noninvasive thermal dosimetry currently is unavailable for clinical retinal photocoagulation, but potential thermometric techniques include MRI, liposomal-encapsulated dyes, multispectral imaging or reflectometry, and subretinal or episcleral thermometry. TTT may be useful not only as independent therapy, but also as an adjunct to PDT, antiangiogenic drugs and ionizing radiation therapy in the management of neovascular ARMD. Low temperature, long-pulse photocoagulation is a potential strategy for decreasing neural retinal damage in subsequent TTT or short-pulse photocoagulation and perhaps even for treating glaucoma or retinal degenerations.
Studying the Influence of Alumina Catalysts Doped with Tin and Zinc Oxides in the Soybean Oil Pyrolysis Reaction (2008)

Abstract The pyrolysis of vegetable oils consists of cracking triglycerides to produce smaller molecules. A mixture of hydrocarbons and oxygenated compounds, such as carboxylic acids and aldehydes, is obtained as the product and which can be separated by fractional distillation. When the reaction is carried out in the absence of catalysts (thermal cracking), a great quantity of these oxygenated compounds is obtained. Thus, the presence of those oxygenated compounds in the products results in a high level of acidity, which can be a problem when using them as fuels in combustion engines. The aim of this work was to study the composition of the products obtained by cracking of vegetable oils assisted by γ‐alumina doped with zinc and tin oxides. The products were analyzed by FT‐IR, GC‐MS and GC‐FID and the acid number was determined by titration with alcoholic KOH solution. The acid number, infrared spectra and chromatograms of the resulting hydrocarbon mixtures indicated a significant reduction in oxygenated compounds when compared with the mixtures obtained by the thermal cracking process, thus decreasing the acidity of the mixture.
Transposase-Mediated Construction of an Integrated Adeno-Associated Virus Type 5 Helper Plasmid (2002)

Adeno-associated viruses (AAVs) are replication-defective parvoviruses that require helper virusfunctionsfor efficient productive replication. The AAVs are currently premier candidates as vectors for human gene therapy applications. In particular; much recent interest has been expressed concerning recombinant AAV serotype 5 (rAAV-5) vectors, as they appear to utilize cellular receptors distinctfrom those of the prototypical AAV serotype (AAV-2) and have been reported to have transduction properties in vivo that differ significantly from those of the prototype. One of the most popular current methodsfor the production of rAAVs involves co-transfection of human 293 cells with three plasmids: (i) an adenovirus (Ad)-derived helper plasmid containing Ad genes required for AAV replication, (ii) an AAV-derived plasmid encoding complementing AAV genes (ie., the viral rep and cap genes), and (iii) a target plasmid containing a transgene of interestflanked by AAV inverted terminal repeats (ITRs) that confer packaging and replication capabilities upon the ITR-flanked heterologous DNA. Here we describe novel plasmid reagents designed for convenient and efficient production of rAAV-S. An integrated helper plasmid containing all Ad genes requiredfor the efficient production of recombinant AAV as well as the complementing AAV genes on the same plasmid backbone, was constructed via transposase-mediated insertion into an Ad helper plasmid of a transposable element containing the AAV-5 rep and cap genes linked to a selectable marker This simple strategy can be used in the rapid and efficient construction of integrated helper plasmids derived from any reported AAV serotype for which a molecular clone exists.
The Inventory of Depressive Symptomatology (IDS): psychometric properties (1996)

The psychometric properties of the 28- and 30-item versions of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) are reported in a total of 434 (28-item) and 337 (30-item) adult out-patients with current major depressive disorder and 118 adult euthymic subjects (15 remitted depressed and 103 normal controls). Cronbach's alpha ranged from 0.92 to 0.94 for the total sample and from 0.76 to 0.82 for those with current depression. Item total correlations, as well as several tests of concurrent and discriminant validity are reported. Factor analysis revealed three dimensions (cognitive/mood, anxiety/arousal and vegetative) for each scale. Analysis of sensitivity to change in symptom severity in an open-label trial of fluoxetine (N = 58) showed that the IDS-C and IDS-SR were highly related to the 17-item Hamilton Rating Scale for Depression. Given the more complete item coverage, satisfactory psychometric properties, and high correlations with the above standard ratings, the 30-item IDS-C and IDS-SR can be used to evaluate depressive symptom severity. The availability of similar item content for clinician-rated and self-reported versions allows more direct evaluations of these two perspectives.
Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments (1999)

The growth-promoting effect of mechanical stress on vascular smooth muscle cells (VSMCs) has been implicated in the progress of vascular disease in hypertension. Extracellular signal-regulated kinases (ERKs) have been implicated in cellular responses, such as vascular remodeling, induced by mechanical stretch. However, it remains to be determined how mechanical stretch activates ERKs. The cytoskeleton seems the most likely candidate for force transmission into the interior of the cell. Therefore, we examined (1) whether the cytoskeleton involves mechanical stretch-induced signaling, (2) whether Rho is activated by stretch, and (3) whether Rho mediates the stretch-induced signaling in rat cultured VSMCs. Mechanical stretch activated ERKs, with a peak response observed at 20 minutes, followed by a significant increase in DNA synthesis. Treatment with the ERK kinase-1 inhibitor, PD98059, inhibited the stretch-induced increase in DNA synthesis. Cytochalasin D, which selectively disrupts the network of actin filaments, markedly inhibited stretch-induced ERK activation. In the control state, RhoA was observed predominantly in the cytosolic fraction, but it was translocated in part to the particulate fraction in response to mechanical stretch. Botulinum C3 exoenzyme, which inactivates Rho p21 (known to participate in the reorganization of the actin cytoskeleton), attenuated stretch-induced ERK activation. Inhibition of Rho kinase (p160ROCK) also suppressed stretch-induced ERK activation dose dependently. Our results suggest that mechanotransduction in VSMCs is dependent on intact actin filaments, that Rho is activated by stretch, and that Rho/p160ROCK mediates stretch-induced ERK activation and vascular hyperplasia.
Complete Wireless Design (2001)

From the Publisher:
Easily design today's wireless systems and circuits 
Design an entire radio system from the ground up instead of relying on a simple plug-in selection of circuits to be modified. Avoid an arduous trek through theory and mathematical derivations. Cotter Sayre's Complete Wireless Design covers wireless hardware design more thoroughly than any other handbook and does it without burying you in math. 
This new guide from today's bestselling wireless author gives you all the skills you need to design wireless systems and circuits. If you want to climb the learning curve with grace, and start designing what you need immediately, this reasonably priced resource is your best choice. It's certain to be the most-used reference in your wireless arsenal for designing cutting-edge filters, amplifiers, RF switches, oscillators, and more. You get: 
Simplified calculations for impedance matching, analysis of wireless links, and completing a frequency plan 
Real-world examples of designing with RFIC's and MMIC's 
Full circuit and electromagnetic software simulations 
More

ON THE CD-ROM
*PUFF RF/Microwave circuit simulation software
*Sonnet Lite electromagnetic simulation software
*National's PLL Design Program
*Agilent's AppCad circuit design program
Design an entire radio system from the ground up instead of relying on a simple plug-in selection of circuits to be modified. Avoid an arduous trek through theory and mathematical derivations. Cotter Sayre's Complete Wireless Design is the handbook that fits your needs. It covers wireless hardware design more thoroughly than any otherand does it without burying you in math.
THE BEST SOURCE FOR WIRELESS DESIGN
*Design cutting-edge filters, amplifiers, RF switches, oscillators, and more
*Simplify calculations for impedance matching, analysis of wireless links, and completing a frequency plan
*Follow real-world examples of designing with RFIC's and MMIC's
*Master full circuit and electromagnetic software simulations
*Limit math to simple algebra
*Get it the first time with Cotter Sayre's copyrighted clarity
THE BEST WRITER IN WIRELESS
This right-on-the-money new guide from a bestselling wireless author gives you all the skills needed to design today's wireless systems and circuits. If you want to climb the learning curve with grace, and start designing what you need immediately, this reasonably priced resource is your best choice. It's certain to be the most-used reference in your wireless arsenal
STEP-SAVING DESIGN
Modulation Oscillators
Amplifiers
Frequency Synthesizers
Filters
Mixers
Support Circuits
Communications Systems
Troubleshooting Using PUFF RF
Directed meta‐Metalation Using Alkali‐Metal‐Mediated Zincation (2006)

Move over directed ortho-metalation, here comes directed meta-metalation. The unprecedented meta-zincation of two anilides by a synergic mixed sodium/zinc dialkyl–amide base is presented. The orientation of the deprotonation of the anilides is remarkably switched to the meta site using this heterometallic mixed-metal system. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600720_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone (1982)

Eight different forms of cytochrome P-450 (P-450) were purified to electrophoretic homogeneity by a common procedure from liver microsomes of rats treated with phenobarbital or beta-naphthoflavone. Antibodies were prepared to seven of these forms in rabbits. The eight P-450s were distinguished by spectral properties of the ferric, ferrous, and ferrous carbonyl forms, apparent monomeric molecular weights, peptide mapping, immunological reactivity as discerned by double-diffusion immunoprecipitin analysis and crossed immunoelectrophoresis, and catalytic activities toward the substrates acetanilide, aminopyrine, aniline, benzo[a]-pyrene, d-benzphetamine, N,N-dimethylnitrosamine, 7-ethoxycoumarin, 7-ethoxyresorufin, ethylmorphine, p-nitroanisole, testosterone, and (R)- and (S)-warfarin. Crossed sodium dodecyl sulfate-polyacrylamide gel immunoelectrophoresis was used to estimate the levels of each of the eight forms of P-450 present in the liver microsomes of untreated rats and rats treated with phenobarbital, 5,6-benzoflavone, pregnenolone-16 alpha-carbonitrile, isosafrole, or the polychlorinated biphenyl mixture Aroclor 1254. In each situation, the sum of the levels of these eight P-450s was at least as high as the spectrally determined P-450 content. The results clearly demonstrate that individual forms of P-450 can be induced by different compounds and that a single compound can lower the level of one form of P-450 while inducing one or more other forms of P-450. Catalytic activities toward each of the substrates observed with microsomal preparations are compared to rates predicted on the basis of the content of each of the eight P-450s. These studies provide a basis for further studies on the regulation of individual P-450s, the physical properties of the different P-450s, and the metabolic consequences of changes in the forms of P-450 in rat liver models.
Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex (2014)

Here we investigated the transduction characteristics of adeno-associated viral vector (AAV) serotypes 1, 2, 5, 8 and 9 in the marmoset cerebral cortex. Using three constructs that each has hrGFP under ubiquitous (CMV), or neuron-specific (CaMKII and Synapsin I (SynI)) promoters, we investigated (1) the extent of viral spread, (2) cell type tropism, and (3) neuronal transduction efficiency of each serotype. AAV2 was clearly distinct from other serotypes in small spreading and neuronal tropism. We did not observe significant differences in viral spread among other serotypes. Regarding the cell tropism, AAV1, 5, 8 and 9 exhibited mostly glial expression for CMV construct. However, when the CaMKII construct was tested, cortical neurons were efficiently transduced (>∼70% in layer 3) by all serotypes, suggesting that glial expression obscured neuronal expression for CMV construct. For both SynI and CaMKII constructs, we observed generally high-level expression in large pyramidal cells especially in layer 5, as well as in parvalbumin-positive interneurons. The expression from the CaMKII construct was more uniformly observed in excitatory cells compared with SynI construct. Injection of the same viral preparations in mouse and macaque cortex resulted in essentially the same result with some species-specific differences.