gebhart/patrepeval huggingface dataset:
An Experimental Evaluation of Data Flow and Mutation Testing (1996)

Two experimental comparisons of data flow and mutation testing are presented. These techniques are widely considered to be effective for unit-level software testing, but can only be analytically compared to a limited extent. We compare the techniques by evaluating the effectiveness of test data developed for each. We develop ten independent sets of test data for a number of programs: five to satisfy the mutation criterion and five to satisfy the all-uses data-flow criterion. These test sets are developed using automated tools, in a manner consistent with the way a test engineer might be expected to generate test data in practice. We use these test sets in two separate experiments. First we measure the effectiveness of the test data that was developed for one technique in terms of the other. Second, we investigate the ability of the test sets to find faults. We place a number of faults into each of our subject programs, and measure the number of faults that are detected by the test sets. Our results indicate that while both techniques are effective, mutation-adequate test sets are closer to satisfying the data flow criterion, and detect more faults.
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis (2005)

Apolipoprotein (apo) B exists in two forms apoB100 and apoB48. ApoB100 is present on very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and LDL. ApoB100 assembles VLDL particles in the liver. This process starts by the formation of a pre-VLDL, which is retained in the cell unless converted to the triglyceride-poor VLDL2. VLDL2 is secreted or converted to VLDL1 by a bulk lipidation in the Golgi apparatus. ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan-binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.
Protein import into the nucleus (1996)

The transport of proteins from the cytoplasm into the nucleus is a multistep process. The nuclear localization sequence (NLS) of a transport substrate associates with the heterodimeric NLS-receptor which binds to a subset of proteins of the nuclear pore complex (NPC). Translocation through the NPC is energy-dependent and requires the small GTPase Ran. Proteins that interact with Ran in either the GDP-bound or the GTP-bound state coordinate transfer through the NPC. Lastly, the NLS-receptor/ substrate complex and Ran reach the nuclear side of the NPC where the complex disassembles.
Design and Synthesis of a Biologically Active Antibody Mimic Based on an Antibody-Antigen Crystal Structure (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesign and Synthesis of a Biologically Active Antibody Mimic Based on an Antibody-Antigen Crystal StructureM. L. Smythe and M. von ItzsteinCite this: J. Am. Chem. Soc. 1994, 116, 7, 2725–2733Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/ja00086a005https://doi.org/10.1021/ja00086a005research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FMS-Like Tyrosine Kinase 3 in Normal Hematopoiesis and Acute Myeloid Leukemia (2006)

Ligand-mediated activation of the FMS-like tyrosine kinase 3 (FLT3) receptor is important for normal proliferation of primitive hematopoietic cells. However, activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival. FLT3 mutations are identified as the most frequent genetic abnormality in acute myeloid leukemia and are also observed in other leukemias. Multiple small-molecule inhibitors are under development to target aberrant FLT3 activity that confers a poor prognosis in patients.
<title>Health monitoring of an adhesive joint using a multiaxis fiber grating strain sensor system</title> (1999)

The use of adhesive joints in aerospace structures is becoming increasingly important. From this, arises the problem of assessing joint integrity quickly, non- intrusively, accurately, and inexpensively. Current methods of assessing joint integrity, such as ultrasonics and x- rays, are time intensive and difficult to interpret. Blue Road Research's solution to monitoring adhesive joint integrity quickly and accurately is to embed non-intrusive, multidimensional optical fiber grating strain sensors into or adjacent to the joints. Aluminum double lap adhesive joints were instrumented with the multi-axis grating strain sensors into or adjacent to the joints. Aluminum double lap adhesive joints were instrumented with the multi-axis senors and subjected to tension and fatigue test. Each specimen contained one sensor located either near the bond, embedded at the edge of the bond, or embedded towards the inner bond area. The joints with senors embedded into the adhesive showed minimal strength degradation. Basically, the multiaxis fiber grating strain sensors were found to provide information about transverse strain, axial strain, and transverse strain gradients that can provide important information throughout the adhesive joint. By changing the orientation of the sensor, shear strain and its effects can be clearly measured.
Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy (2018)

The recent success of checkpoint-inhibitors in cancer treatment paved the way for the development of new strategies of agonist and antagonist agents against B7 superfamily members. Inducible Co-Stimulator (ICOS), a co-stimulatory receptor for T-cell enhancement, arouses interest. Areas covered: We performed an extensive literature search with PUBMED using the keywords 'ICOS' and 'cancer' to discuss its involvement in oncogenesis, its expression in different malignancies, and its targeting in relevant preclinical studies. We also searched the Clinicaltrials.gov database for recent updates on early phase clinical trials. Expert opinion: ICOS/ICOSL axis has a dual effect and might participate in anti-tumour T cell response as well as a pro-tumour response due to its connection with regulatory T-cells (Tregs) suppressive activity. Therefore, both antagonist and agonist antibodies might be of interest in the targeting ICOS/ICOSL pathway for cancer treatment. In preclinical studies, ICOS agonist monoclonal antibodies (mAbs) have shown to potentiate the effect of inhibitory checkpoint blockade. In contrast, antagonistic anti-ICOS mAbs could not only inhibit lymphoid tumour cells expressing ICOS, but also dampen immunosuppressive Tregs. Two agonist and one antagonist mAbs are evaluated in phase I/II trials. Efficacy, safety, and combination strategies with anti-ICOS agonist or antagonist have yet to be specified.
Growth Behaviour of Athermal &omega;-Phase Crystals in a Ti-15mass%Mo Alloy Studied by <I>In-situ</I> Dark Field and High Resolution Electron Microscopy (1999)

The formation of athermal ω-phase crystals in β-Ti alloys has been postulated based on the negative temperature dependence of electrical resistivity. However, no direct evidence has been reported. In order to clarify the formation and morphology of athermal ω-phase crystals in Ti-15mass%Mo alloys cooled to and held at 131 K, in-situ dark field image observations and high resolution electron microscope (HREM) observations were carried out using a TV-VTR system. It was found that athermal ω-phase crystals with spherical shape and a size of approximately 20 nm were formed by cooling to 131 K in areas that were not irradiated by electrons, but, no formation was observed in areas irradiated by electrons. HREM images of the athermal ω-phase crystals revealed the atomic structure of ω-phase crystals. Athermal ω-phase crystals formed by cooling were annihilated by electron irradiation, and the stability depended on the holding period at 131 K, that is, the longer the period, the more stable the crystals became. The annihilation caused by the temperature rise from 131 to 200 K was a function of time. The annihilation was noticed at 1680 s, but not at 780 s. This fact suggests that an incubation time exists in the case of the ω\ ightleftharpoonsβ transformations. It seems that the β\ ightleftharpoonsω phase transformations indicate hysteresis.
Second-look laparoscopy prior to proposed second-look laparotomy. (1980)

A prospective study was carried out to evaluate the use of second-look laparoscopy in patients in complete clinical remission after prolonged chemotherapy for advanced ovarian adenocarcinoma. Twenty-two patients with FIGO stages IIB, III, and IV ovarian adenocarcinoma underwent second-look laparoscopy after a median of 23 months of therapy. Eight (36.3%) patients had documented evidence of persistent ovarian cancer and were thus spared second-look laparotomy. Moreover, in 4 patients (18.1%), malignant cells in cytologic washings were the only laparoscopic evidence of persistent ovarian cancer. The absence of visible tumor and malignant cells in cytologic washings allows for the use of second-look laparotomy while the patient is under 1 anesthesia; the presence of tumor or malignant cells in cytologic washings spares the patient second-look laparotomy at that time.
Multifrequency operation of microstrip antennas using aperture-coupled parallel resonators (1992)

A microstrip antenna composed of parallel dipole resonators of different lengths fed by a rectangular slot cut in the ground plane of a microstrip line is analyzed using an integral equation technique solved in the spectral domain using the Galerkin method of moments. Multifrequency operation of this antenna is demonstrated using two different configurations. Experimental data are shown to be in good agreement with predicted results. The fundamental parameters influencing the realization of multifrequency operation, as well as impedance matching of the different resonances, are studied. Lastly, the radiation patterns of the antenna at different frequencies and the relative contribution of the dipoles to the radiation are investigated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor (1992)

The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects. The ligand-bound receptor activates Cyp 1a1 gene transcription through interaction with specific DNA sequences, termed xenobiotic responsive elements (XREs). The Ah receptor nuclear translocator protein (Arnt) is required for Ah receptor function. Arnt is now shown to be a structural component of the XRE binding form of the Ah receptor. Furthermore, Arnt and the ligand-binding subunit of the receptor were extracted as a complex from the nuclei of cells treated with ligand. Arnt contains a basic helix-loop-helix motif, which may be responsible for interacting with both the XRE and the ligand-binding subunit.
Mechanisms of Silk Fibroin Sol−Gel Transitions (2006)

Silk fibroin sol-gel transitions were studied by monitoring the process under various physicochemical conditions with optical spectroscopy at 550 nm. The secondary structural change of the fibroin from a disordered state in solution to a beta-sheet-rich conformation in the gel state was assessed by FTIR and CD over a range of fibroin concentrations, temperatures, and pH values. The structural changes were correlated to the degree of gelation based on changes in optical density at 550 nm. No detectable changes in the protein secondary structure (FTIR, CD) were found up to about 15% gelation (at 550 nm), indicating that these early stages of gelation are not accompanied by the formation of beta-sheets. Above 15%, the fraction of beta-sheet linearly increased with the degree of gelation. A pH dependency of gelation time was found with correlation to the predominant acidic side chains in the silk. Electrostatic interactions were related to the rate of gelation above neutral pH. The overall independencies of processing parameters including concentration, temperature, and pH on gel formation and protein structure can be related to primary sequence-specific features in the molecular organization of the fibroin protein. These findings clarify aspects of the self-assembly of this unique family of proteins as a route to gain control of material properties, as well as for new insight into the design of synthetic silk-biomimetic polymers with predictable solution and assembly properties.
Modern Organic Synthesis in the Laboratory (2008)

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.
Wrapping carbon nanotubes with DNA: A theoretical study (2005)

A series of recent experimental studies indicate a considerable interaction of DNA with carbon nanotubes (CNTs). Experiments performed at DuPont showed that CNT bundles can be effectively suspended by sonicating in a DNA solution. Motivated by these experiments, we have investigated the nature of these interactions theoretically. Our density functional (DFT) based calculations showed that there does not exists any covalent interaction between DNA and CNT, but there do exist long range van der Waal’s interactions.
Serum antibodies against intact human collagen IX are elevated at onset of rheumatoid arthritis but are not related to development of erosions. (2008)

Our data show that patients with recent-onset RA have significantly elevated levels of autoantibodies to human rCIX. These autoantibodies were observed already at the early stages of the disease, which may reflect their diagnostic potential in RA.
<p>Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications</p> (2020)

Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body's physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.
Nutrition and mental development. (1984)

It has been difficult to assess the effects of malnutrition upon mental development because of the environmental alterations that invariably accompany malnutrition, even in animal models. In rats, maternal behavior is altered whenever offspring are malnourished, in part in response to the altered stimulus characteristics of the offspring. It is difficult to assess whether these alterations in environment are detrimental because they are adaptive in promoting the growth of the pups. Environmental stimulation may to some extent reverse the brain effects of malnutrition and can remediate some of the behavioral effects.
Elastic Response of Carbon Nanotube Bundles to Visible Light (1999)

Distinct macroscopic movements of the filaments consisted of single-wall carbon nanotube bundles were observed under visible light illumination. The movements, sensitive to the intensity of the light, were attributed to the elastic deformations of the bundles of nanotubes. Light-induced electrical currents in the carbon nanotube filaments aligned between two metal electrodes were also observed. The mechanism for the observed phenomena is discussed by considering the physical interlinks of the optical, thermal, electrical, and elastic effects of nanotube bundles.
[A role for T-helper type 1 and type 2 cytokines in the pathogenesis of various human diseases]. (1998)

Mosmann first proposed the existence of subsets of CD4+ T cells that produce distinct types of cytokines. Native T lymphocytes (Thp cells) differentiates into either CD4+ Th1 cells that produce IL-2, IFN gamma, and lymphotoxin which promote cell-mediated immunity, or into Th2 cells that produce IL-4, IL-5, IL-6, IL-10 and IL-13, which promote antibody production and humoral immunity. These T cell subsets reciprocally regulate one another since one of the Th1 products, IFN gamma, inhibits the proliferation and functions of Th2 cells, whereas the Th2 products, IL-4 and IL-10, suppress cytokine production by Th1 cells. A distinct Th1/Th2 divergence determine resistance versus susceptibility to diseases such as leishmaniasis and toxoplasmosis in mice. In allergic diseases such as atopic dermatitis and allergic asthma, allergen-specific T cells acquired the Th2 phenotype. These Th2 cells produce IL-4, IL-5, IL-6, IL-10 and IL-13. These cytokines induce eosinophilia and an Ig class switch to IgG4 and IgE. These Th2 cells are responsible for the enhanced production of IgE antibodies. These findings indicate that Th2 cytokines play an important role in the development of allergic diseases. The importance of cell-mediated immunity, particularly donor-anti-host CTL, in mediating acute GVHD suggests that Th1 cytokines may be important in the induction of acute GVHD. To further characterize the roles of Th1 and Th2 cytokines in the development of acute GVHD, analysis of IL-2, IFN gamma, IL-4 and IL-10 cytokine genes was performed by RT-PCR on biopsied skin specimen. An increase in mRNA expression for IL-2 and IFN gamma was observed, whereas there was no significant increase in IL-4 and IL-10 mRNA. These data suggest that Th1 cytokines may be essential for the development of acute GVHD. It is apparent that Th1 cytokines are generally harmful to the maintenance of pregnancy. We have shown that Th2 cytokines are produced by maternal T lymphocytes at the maternal-fetal surface (retroplacental blood lymphocytes). This finding strengthens the hypothesis of a significant contribution of Th2 cytokines to a successful pregnancy.
Semantic Interoperability of Web Services - Challenges and Experiences (2006)

With the rising popularity of Web services, both academia and industry have invested considerably in Web service description standards, discovery, and composition techniques. The standards based approach utilized by Web services has supported interoperability at the syntax level. However, issues of structural and semantic heterogeneity between messages exchanged by Web services are far more complex and crucial to interoperability. It is for these reasons that we recognize the value that schema/data mappings bring to Web service descriptions. In this paper, we examine challenges to interoperability; classify the types of heterogeneities that can occur between interacting services and present a possible solution for data mediation using the mapping support provided by WSDL-S, the extensibility features of WSDL and the popular SOAP engine, Axis 2
Haemophilia B: current pharmacotherapy and future directions (2012)

Although the availability of plasma-derived FIX concentrates has greatly improved the clinical management of hemophilia B patients, the introduction of FIX products using recombinant DNA technology has represented the most significant therapeutic progress in hemophilia B therapy, ensuring an advanced level of safety. The development of rFIX products with extended half lives will further improve the therapeutic armamentarium for hemophilia B patients.
Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules. (1985)

Antiserum to the Rous sarcoma virus (RSV)-transforming protein, pp60v-src, was produced in rabbits immunized with p60 expressed in Escherichia coli. alpha p60 serum immunoprecipitated quantitatively more pp60v-src than did tumor-bearing rabbit (TBR) sera. When RSV-transformed cell lysates were preadsorbed with TBR serum, the remaining lysate contained additional pp60v-src, which was recognized only by reimmunoprecipitation with alpha p60 serum and not by TBR serum. In subcellular fractions of RSV-infected chicken embryo fibroblasts (RSV-CEFs) and field vole cells probed with TBR serum, the majority of the pp60v-src was associated with the plasma membrane-enriched P100 fraction. However, alpha p60 serum revealed equal distribution of pp60v-src and its kinase activity between the P1 (nuclear) and P100 fractions. The same results were obtained for pp60c-src in uninfected CEFs. On discontinuous sucrose gradients nearly 50% of the P1-pp60v-src sedimented with nuclei, in fractions where no plasma membrane was detected. Indirect immunofluorescence microscopy of RSV-CEFs with alpha p60 serum revealed a distinct pattern of perinuclear fluorescence, in addition to staining at the cell periphery. Thus the use of a highly specific antibody reveals that enzymatically active pp60v-src and pp60c-src molecules are present in other intracellular structures, probably juxtareticular nuclear membranes, in addition to the plasma membrane in normal, uninfected, and wild-type RSV-infected cells.