gebhart/patrepeval huggingface dataset:
<title>Experimental demonstration of real-time image processing using a VLSI analog programmable array processor</title> (2000)

This paper describes a full-custom mixed-signal chip which embeds distributed optical signal acquisition, digitallyprogrammable&#13;\nanalog parallel processing, and distributed image memory —cache— on a common silicon substrate. This chip,&#13;\ndesigned in a O.5ptm CMOS standard technology contains around 1, 000, 000 transistors, 80% of which operate in analog&#13;\nmode; it is hence one the most complex mixed-signal chip reported to now. Chip functional features are in accordance to the&#13;\nCNN Universal Machine paradigm: cellular, spatial-invariant array architecture; programmable local interactions among&#13;\ncells; randomly-selectable memory of instructions (elementary instructions are defined by specific values of the cell local&#13;\ninteractions); random storage/retrieval of intermediate images; capability to complete algorithmic image processing tasks&#13;\ncontrolled by the user-selected stored instructions and interacting with the cache memory, etc. Thus, as illustrated in this&#13;\npaper, the chip is capable to complete complex spatio-temporal image processing tasks within short computation time&#13;\n( 200ns for linear convolutions) and using a low power budget (&lt;1.2W for the complete chip). The internal circuitry of the&#13;\nchip has been designed to operate in robust manner with &gt;7-bit equivalent accuracy in the internal analog operations, which&#13;\nhas been confirmed by experimental measurements. Hence, to all practical purposes, processing tasks completed by the chip&#13;\nhave the same accuracy than those completed by digital processors preceded by 7-bit digital-to-analog converters for image&#13;\ndigitalization. Such 7-bit accuracy is enough for most image processing applications.&#13;\nThe paper briefly describes the chip architecture and focus mostly on presenting experimental evidences of the chip&#13;\nfunctionality. Multiscale low-pass and high-pass filtering ofgray-scale images, analog edges extraction, image segmentation,&#13;\nthresholded gradient detection, mathematical morphology operations, shortest path detection in a labyrinth, skeletonizing,&#13;\nimage reconstruction, several non-linear type image processing taks like absolute value calculation or gray-scale gradient&#13;\ndetection and real-time motion detection in QCIF video sequences are some of the very interesting applications that have&#13;\nbeen demonstrated as available when using the prototype.
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target (1999)

AMP-activated kinase (AMPK) is activated in response to metabolic stresses that deplete cellular ATP, and in both liver and skeletal muscle, activated AMPK stimulates fatty acid oxidation. To determine whether AMPK might reciprocally regulate glycerolipid synthesis, we studied liver and skeletal-muscle lipid metabolism in the presence of 5-amino-4-imidazolecarboxamide (AICA) riboside, a cell-permeable compound whose phosphorylated metabolite activates AMPK. Adding AICA riboside to cultured rat hepatocytes for 3 h decreased [14C]oleate and [3H]glycerol incorporation into triacylglycerol (TAG) by 50% and 38% respectively, and decreased oleate labelling of diacylglycerol by 60%. In isolated mouse soleus, a highly oxidative muscle, incubation with AICA riboside for 90 min decreased [14C]oleate incorporation into TAG by 37% and increased 14CO2 production by 48%. When insulin was present, [14C]oleate oxidation was 49% lower and [14C]oleate incorporation into TAG was 62% higher than under basal conditions. AICA riboside blocked insulin's antioxidative and lipogenic effects, increasing fatty acid oxidation by 78% and decreasing labelled TAG 43%. Similar results on fatty acid oxidation and acylglycerol synthesis were observed in C2C12 myoblasts, and in differentiated C2C12 myotubes, AICA riboside also inhibited the hydrolysis of intracellular TAG. These data suggest that AICA riboside might inhibit sn-glycerol-3-phosphate acyltransferase (GPAT), which catalyses the committed step in the pathway of glycerolipid biosynthesis. Incubating rat hepatocytes with AICA riboside for both 15 and 30 min decreased mitochondrial GPAT activity 22-34% without affecting microsomal GPAT, diacylglycerol acyltransferase or acyl-CoA synthetase activities. Finally, purified recombinant AMPKalpha1 and AMPKalpha2 inhibited hepatic mitochondrial GPAT in a time-and ATP-dependent manner. These data show that AMPK reciprocally regulates acyl-CoA channelling towards beta-oxidation and away from glycerolipid biosynthesis, and provide strong evidence that AMPK phosphorylates and inhibits mitochondrial GPAT.
Asenapine for the treatment of adults with an acute exacerbation of schizophrenia: results from a randomized, double-blind, fixed-dose, placebo-controlled trial with olanzapine as an active control (2016)

This study supports previous efficacy and safety findings of asenapine; asenapine 5 mg bid is the lowest effective dose in adults with schizophrenia. Asenapine was associated with significantly less weight gain than olanzapine at day 42.
How to personalize the Web (1997)

Article Free Access Share on How to personalize the Web Authors: Rob Barrett IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Paul P. Maglio IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile , Daniel C. Kellem IBM Almaden Research Center, 650 Harry Road, San Jose, CA IBM Almaden Research Center, 650 Harry Road, San Jose, CAView Profile Authors Info & Claims CHI '97: Proceedings of the ACM SIGCHI Conference on Human factors in computing systemsMarch 1997 Pages 75–82https://doi.org/10.1145/258549.258595Published:27 March 1997Publication History 89citation1,259DownloadsMetricsTotal Citations89Total Downloads1,259Last 12 Months48Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Constructive Incremental Learning from Only Local Information (1998)

We introduce a constructive, incremental learning system for regression problems that models data by means of spatially localized linear models. In contrast to other approaches, the size and shape of the receptive field of each locally linear model, as well as the parameters of the locally linear model itself, are learned independently, that is, without the need for competition or any other kind of communication. Independent learning is accomplished by incrementally minimizing a weighted local cross-validation error. As a result, we obtain a learning system that can allocate resources as needed while dealing with the bias-variance dilemma in a principled way. The spatial localization of the linear models increases robustness toward negative interference. Our learning system can be interpreted as a nonparametric adaptive bandwidth smoother, as a mixture of experts where the experts are trained in isolation, and as a learning system that profits from combining independent expert knowledge on the same problem. This article illustrates the potential learning capabilities of purely local learning and offers an interesting and powerful approach to learning with receptive fields.
Autorosette Inhibition Factor: Isolation and Properties of the Human Plasma Protein (1981)

The sera of many vertebrates, including man, contain a factor, termed autorosette inhibition factor. Which can inhibit the ability of murine lymphocytes to bind autologous erythrocytes. Utilizing the strong affinity of this inhibitor for phosphocellulose, a one-column procedure has been developed for the isolation fo autorosette inhibition factor which gives a one-thousand-fold purification with eighty-five percent recovery of biological activity. Both polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulphate and gel filtration of the purified protein gave apparent molecular weights of 80000 and the glycoprotein appears to be present in serum at levels of 5-20mg/100ml (approximately 1μM) and can completely block murine autorosetting at concentrations of 50nM. Amino acid analysis of human autorosette inhibition factor suggested that this protein might be closely related to the previously described lower molecular weight, histidine-rich glycoprotein[Heimburger, N., Haupt, H., Kranz, T., and baudner, S. (1972) Hoppe-Seylers' Z. physiol Chem 353, 10214-10222]. In support of this notion was the observation that purified human autorosette inhibition factor crossreacted strongly with a monospecific antiserum to histidine-rich glycoprotein and this antiserum also neutralized the biological activity of autoreosette inhibition factor. These results are consistent with autorosette inhibition factor being a larger molecular weight precursor from which histidine-rich glycoprotein and possibly, plasminogen-binding protein are derived by proteolysis during purification.
Specific binding of Hoechst 33258 to site 1 thymidylate synthase mRNA (2000)

The translational initiator codon in thymidylate synthetase (TS) mRNA is located in a stem-loop structure with a CC bubble. TS is an important target for anticancer drugs. Aminoglycoside antibiotics have been shown to specifically bind to TS mRNA site 1 constructs and, furthermore, specific binding requires the non-duplex CC bubble region. It is shown here that DNA intercalating agents and DNA minor groove-binding drugs also bind to a TS mRNA site 1 construct. This binding is competitive with aminoglycosides, suggesting that the binding sites overlap. Hoechst 33258 binds with a dissociation constant of 60 nM, a value significantly lower than the approximately 1 microM values found for aminoglycosides. Footprinting and direct binding studies show that the CC bubble is important for binding of the Hoechst compound. However, the exact structure of the bubble is unimportant. Interestingly, mutations in regions adjacent to the bulge also affect binding. These studies point to the important role of non-duplex RNA structures in binding of the DNA minor groove binder Hoechst 33258.
Characterization of small nontranslated polyadenylylated RNAs in vaccinia virus-infected cells. (1996)

Host protein synthesis is selectively inhibited in vaccinia virus-infected cells. This inhibition has been associated with the production of a group of small, nontranslated, polyadenylylated RNAs (POLADS) produced during the early part of virus infection. The inhibitory function of POLADS is associated with the poly(A) tail of these small RNAs. To determine the origin of the 5'-ends of POLADS, reverse transcription was performed with POLADS isolated from VV-infected cells at 1 hr and 3.5 hr post infection. The cDNAs of these POLADS were cloned into plasmids (pBS or pBluescript II KS +/-), and their nucleotide composition was determined by DNA sequencing. The results of this investigation show the following: There is no specific gene encoding for POLADS. The 5' ends of POLADS may be derived from either viral or cellular RNAs. Any RNA sequence including tRNAs, small nuclear RNAs and 5'ends of mRNAs can become POLADS if they acquire a poly(A) tail at their 3' ends during infection. This nonspecific polyadenylylation found in vaccinia virus-infected cells is probably conducted by vaccinia virus poly(A)+ polymerase. No consensus sequence is found on the 5' ends of POLADS for polyadenylylation. The 5' ends of POLADS have no direct role in their inhibitory activity of protein synthesis.
Comparison of sources and levels of job stress of critical care nurses in government and private medical college hospitals of Kerala (2012)

Occupational stress in nursing and its causes and effects have been the areas of research interest for many years. Critical Care Units are highly technological areas where nurses are required to make rapid life sustaining and life saving decisions. Therefore, Comparative descriptive study was conducted among 100 CCU nurses working in Medical College Hospitals, Kerala to assess the sources and levels of stress. The results revealed that the nurses working in Government hospital generally reported more stress than private hospitals. The commonest stress dimensions were caring for patients, general job requirements and workload for both the sector nurses though the order differed.
Eliminating multiple modes of vibration in a flexible manipulator (2002)

Vibration suppression is often difficult to achieve in systems whose parameters are a function of configuration. A modified command filtering technique is proposed that eliminates the first two modes of vibration in a large, flexible manipulator with position-dependent parameters. The elimination of residual vibration is demonstrated using a circular trajectory located in the workspace of the manipulator so that a change in system properties occurs. The modified command filtering technique is compared to previous control methods in order to demonstrate its effectiveness in eliminating residual vibration.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Microtiter ganglioside enzyme-linked immunosorbent assay for vibrio and Escherichia coli heat-labile enterotoxins and antitoxin (1980)

We have developed a microtiter enzyme-linked immunosorbent assay method for detecting the heat-labile enterotoxins of Vibrio cholerae and Escherichia coli using GM1 ganglioside as the base coat. This method compares favorably with a similar assay using anticholera toxin as the base coat, and with the Y1 adrenal cell assay. The assay should be useful in detecting enterotoxin production in E. coli and vibrios (including non-agglutinating Vibrio), in quantitating the toxin, and in determining binding properties of enterotoxins to ganglioside. The assay can also be used to quantitate antibodies which block the attachment of the toxin to the ganglioside.
Sendai virus-like particles devoid of haemagglutinin-neuraminidase protein infect cells via the human asialoglycoprotein receptor. (1998)

Virus-like particles with genetically defined envelope proteins were generated from cDNA in order to examine the requirement of Sendai virus haemagglutinin-neuraminidase (HN) protein for particle formation, and the role of fusion protein (F) in receptor binding and membrane fusion. Characterization of particles devoid of HN protein showed that particle formation was unimpaired by the absence of HN protein, indicating that HN protein is dispensable for virus assembly and budding. Infection studies further demonstrated that virus adsorption and penetration can be mediated solely by the F protein when the human asialoglycoprotein receptor is present at the surface of host cells.
Catalytic organometallic chemistry in water: the aqueous ring-opening metathesis polymerization of 7-oxanorbornene derivatives (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic organometallic chemistry in water: the aqueous ring-opening metathesis polymerization of 7-oxanorbornene derivativesBruce M. Novak and Robert H. GrubbsCite this: J. Am. Chem. Soc. 1988, 110, 22, 7542–7543Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/ja00230a047https://doi.org/10.1021/ja00230a047research-articleACS PublicationsRequest reuse permissionsArticle Views2044Altmetric-Citations225LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin (2003)

Dystrophin gene transfer using helper-dependent adenoviruses (HDAd), which are deleted of all viral genes, is a promising option to treat muscles in Duchenne muscular dystrophy. We investigated the benefits of this approach by injecting the tibialis anterior (TA) muscle of neonatal and juvenile (4-6-week-old) dystrophin-deficient (mdx) mice with a fully deleted HDAd (HDCBDysM). This vector encoded two full-length murine dystrophin cDNAs regulated by the powerful cytomegalovirus enhancer/beta-actin promoter. At 10 days post-injection of neonatal muscles, 712 fibers (42% of the total number of TA fibers) were dystrophin-positive (dys+), a value that did not decrease for 6 months (the study duration). In treated juveniles, maximal transduction occurred at 30 days post-injection (414 dys+ fibers, 24% of the total number of TA fibers), but decreased by 51% after 6 months. All studied aspects of the pathology were improved in neonatally treated muscles: the percentage of dys+ fibers with centrally localized myonuclei remained low, localization of the dystrophin associated protein complex was restored at the plasma membrane, muscle hypertrophy was reduced, and maximal force-generating capacity and resistance to contraction-induced injuries were increased. The same pathological aspects were improved in the treated juveniles, except for reduction of muscle hypertrophy and maximal force-generating capacity. We demonstrated a strong humoral response against murine dystrophin in both animal groups, but mild inflammatory response occurred only in the treated juveniles. HDCBDysM is thus one of the most promising and efficient vectors for treating DMD by gene therapy.
Machine Learning of Text Analysis Rules for Clinical Records (1995)

... This paper describes the BADGER text analysis system, which identifies concepts contained in a text based on linguistic context. A key component of BADGER is the CRYSTAL dictionary induction system that automatically learns text analysis rules from a set of training documents. Each of these rules is generalized as far as possible without producing errors, so that a minimum number of dictionary entries cover the positive training instances.
Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice (2002)

The glycoprotein CD47 (integrin-associated protein, IAP) is present on the surface of virtually all cells, including red blood cells (RBCs). CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha (SIRPalpha). In this manner mild reactivity of wild-type RBCs with macrophage phagocytic receptors is tolerated, whereas otherwise identical CD47-deficient RBCs are rapidly eliminated. We show here that virtually all CD47-deficient nonobese diabetic (NOD) mice spontaneously develop severe lethal autoimmune hemolytic anemia (AIHA) at 180 to 280 days of age, whereas none of the control CD47(+) NOD mice develop lethal AIHA at least during the first year of life. This phenotype is at least partially due to a markedly increased rate of elimination of opsonized CD47(-/-) compared to CD47(+) RBCs. Similarly, CD47(-/-)C57BL/6 mice were much more sensitive than their wild-type counterparts to experimental passive AIHA induced by anti-RBC monoclonal antibodies. Thus, CD47-SIRPalpha signaling can have a profound influence on the severity of AIHA, making manipulation of this signaling pathway a theoretically appealing avenue in the treatment of the disease.
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins (1987)

Antibody response in mice to scrapie-associated fibril proteins (protease-resistant proteins [PrPs]) was generated to different epitopes depending on the source of antigen. Mice responded differently to PrPs isolated from scrapie-infected animals of homologous (mouse) versus heterologous (hamster) species. An enzyme-linked immunosorbent assay established to monitor this antibody response in mice immunized with PrPs was unable to detect such a response in scrapie-infected mice. A monoclonal antibody (MAb), 263K 3F4, derived from a mouse immunized with hamster 263K PrPs reacted with hamster but not mouse PrPs. MAb 263K 3F4 also recognized normal host protein of 33 to 35 kilodaltons in brain tissue from hamsters and humans but not from bovine, mouse, rat, sheep, or rabbit brains. This is the first demonstration of epitope differences on this host protein in different species. The defining of various epitopes on PrP through the use of MAbs will lead to a better understanding of the relationship of PrPs to their host precursor protein and to the infectious scrapie agent.
The influence of trapping agents on the antitumor efficacy of irinotecan liposomes: head-to-head comparison of ammonium sulfate, sulfobutylether-β-cyclodextrin and sucrose octasulfate (2018)

Remote loading technology is an outstanding achievement in liposome-based drug delivery systems. Compared with conventional passive loading, remote loading technology exhibits unique superiority in terms of high drug loading efficiency, low leakage rate and adequate drug accumulation. In the intra-liposome aqueous phase, the counterion of the trapping agent can control the state of aggregation/crystallization of the drug-counterion salt, and thereby contribute to control the efficiency of remote loading. Herein, irinotecan (CPT-11)-loaded liposomes were developed using three trapping agents: ammonium sulfate (AS), sulfobutylether-β-cyclodextrin (SBE-β-CD) and sucrose octasulfate (SOS). The corresponding formulations were named as AS liposomal CPT-11, TEA-SBE-β-CD liposomal CPT-11 and TEA-SOS liposomal CPT-11, respectively. Cryo-transmission electron micrographs showed that bundles of CPT-11 fibers were gathered inside TEA-SOS liposomal CPT-11. Furthermore, compared with AS liposomal CPT-11 and TEA-SBE-β-CD liposomal CPT-11, TEA-SOS liposomal CPT-11 demonstrated slower drug release, prolonged circulation time and significantly improved antitumor efficiency. To avoid the protection of ONIVYDE®-related patents, a number of other liposomal CPT-11 formulations are under preclinical investigation or even in clinical trials. Our study gives new insights into the impact of the trapping agent on remote loading, and provides valuable information to evaluate the development of CPT-11 loaded liposomes.