gebhart/patrepeval huggingface dataset:
Studies on Blood Fibrinolytic Activity and Muscle Blood Flow in Patients with Occulsive Arterial Disease and Diabetes Mellitus (1975)

閉塞性動脈疾患および閉塞性動脈硬化症を合併しやすいといわれている糖尿病において, 血液線溶活性の低下, 高フィブリノーゲン血症が, どの程度血流障害因子として働いているかを検討する目的で血液線溶活性と筋血流量とを同時に測定して検討してみた.症例は未治療の閉塞性動脈硬化症44例, 治療中の糖尿病患者40例で, 血漿フィブリノーゲン値, フィブリン平板法による血液線溶活性, Xe-133クリアランス法による下肢前脛骨筋の虚血後の反応性充血血流量を同時に測定した. また6例の閉塞性血栓性血管炎については同時測定を行わずに別々に検査を行った.筋血流量の健常対照例としては健常人10例 (20肢) を用い, 血液線溶活性, フィブリノーゲン値測定の健常対照例としては14例の健常人を用いた.血漿フィブリノーゲン値は閉塞性動脈硬化症では, 平均379.5±S. E. 22.3mg/dlで, 健常対照群 (平均300.9±8.8mg/dl) に比較して有意 (p<0.01)に高く, 閉塞性血栓性血管炎では282.3±23.7mg/dl, 糖尿病では319.2±19.1mg/dlであった. Euglobulin による標準平板の溶解能は健常対照群では平均107.0±5.1mm2で, 閉塞性血栓性血管炎, 糖尿病ではそれぞれ67.0±14.4mm2 (p<0.01), 67.5±6.6mm2 (p<0.01) であった. ストレプトキナーゼ添加 Euglobulin による加熱平板の溶解能は閉塞性動脈硬化症 (P<0.05) および閉塞性血栓性血管炎 (p<0.01) では有意の上昇をみた.筋血流量は健常対照群では平均21.7±1.2ml/100g/minであったが, 閉塞性動脈硬化症では健肢11.8±1.8ml (以下/100g/minを省略), 患肢10.0±0.7ml, 閉塞性血栓性血管炎では健肢13.3±1.4ml, 患肢13.1±1.9ml, 糖尿病では 14.9±1.2mlで, 各疾患群では健肢, 患肢ともに筋血流量の有意 (p<0.01およびp<0.05) の低下がみられた.そこで筋血流量を血流障害因子の1つである血漿フィブリノーゲン値と対比して考察したところ, 既発表の高安病の健肢から得られたようなきれいな相関はみられず, 血流障害因子としては血漿フィブリノーゲン値のほかの他の要素も考慮しなけれぼならないことがわかった. これらの要素としては閉塞性動脈硬化症においては当然のことながら動脈閉塞であるが, 糖尿病においては細動脈領域の機能的または器質的な血管障害のあることを考えなければならないという結論に到達した.
Pulse arrival time is not an adequate surrogate for pulse transit time as a marker of blood pressure (2011)

Pulse transit time (PTT) is a proven, simple to measure, marker of blood pressure (BP) that could potentially permit continuous, noninvasive, and cuff-less BP monitoring (after an initial calibration). However, pulse arrival time (PAT), which is equal to the sum of PTT and the pre-ejection period, is gaining popularity for BP tracking, because it is even simpler to measure. The aim of this study was to evaluate the hypothesis that PAT is an adequate surrogate for PTT as a marker of BP. PAT and PTT were estimated through the aorta using high-fidelity invasive arterial waveforms obtained from six dogs during wide BP changes induced by multiple interventions. These time delays and their reciprocals were evaluated in terms of their ability to predict diastolic, mean, and systolic BP (DBP, MBP, and SBP) per animal. The root mean squared error (RMSE) between the BP parameter predicted via the time delay and the measured BP parameter was specifically used as the evaluation metric. Taking the reciprocals of the time delays tended to reduce the RMSE values. The DBP, MBP, and SBP RMSE values for 1/PAT were 9.8 ± 5.2, 10.4 ± 5.6, and 11.9 ± 6.1 mmHg, whereas the corresponding values for 1/PTT were 5.3 ± 1.2, 4.8 ± 1.0, and 7.5 ± 2.2 mmHg (P < 0.05). Thus tracking BP via PAT was not only markedly worse than via PTT but also unable to meet the FDA BP error limits. In contrast to previous studies, our results quantitatively indicate that PAT is not an adequate surrogate for PTT in terms of detecting challenging BP changes.
Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells (1985)

Peripheral blood lymphocytes from patients with chronic lymphocytic leukemia (CLL) acquire after several days of exposure to 12‐ O ‐tetradecanoylphobol‐13‐acetate (TPA) several morphological, immunological and histochemical features of hairy cell leukemia. We have investigated the short term effects of TPA treatment on protein kinase C and its subcellular distribution. Within minutes of addition of TPA to CLL cells 20% of the cytosolic protein kinase C had associated with the particulate fraction. The remaining 80% of protein kinase C activity was down‐regulated. The association with the membrane dramatically increased the resistance of the enzyme to inhibition by the non‐ionic detergent, Triton X‐100. These results suggest that activation of protein kinase C causes multiple biological changes in CLL cells.
BSAVA EDUCATION COMMITTEE COMMISSIONED ARTICLE (1986)

ABSTRACT The current knowledge on canine atopic dermatitis (syn. canine inhalant dermatitis, atopy) is reviewed. The significance of history, clinical signs and in vitro and in vivo allergy tests is emphasized.
Clustering by Passing Messages Between Data Points (2007)

Clustering data by identifying a subset of representative examples is important for processing sensory signals and detecting patterns in data. Such "exemplars" can be found by randomly choosing an initial subset of data points and then iteratively refining it, but this works well only if that initial choice is close to a good solution. We devised a method called "affinity propagation," which takes as input measures of similarity between pairs of data points. Real-valued messages are exchanged between data points until a high-quality set of exemplars and corresponding clusters gradually emerges. We used affinity propagation to cluster images of faces, detect genes in microarray data, identify representative sentences in this manuscript, and identify cities that are efficiently accessed by airline travel. Affinity propagation found clusters with much lower error than other methods, and it did so in less than one-hundredth the amount of time.
NanoSail-D: The First Flight Demonstration of Solar Sails for Nanosatellites (2008)

The AR application to learn how to properly use ceiling-suspended radiation shielding screens was highly rated from the perspective of learner motivation.
The recombination signals for adeno-associated virus site-specific integration. (1996)

The adeno-associated virus (AAV) genome integrates site specifically into a defined region of human chromosome 19 (termed AAVS1). Using a functional assay for AAV integration into AAVS1 DNA propagated as an episome, we obtained evidence that a 33-nucleotide AAVS1 DNA sequence contains the minimum signal required for targeted integration. The recombination signal comprises a DNA-binding motif for the AAV regulatory Rep protein [Rep binding site (RBS)] separated by an eight-nucleotide spacer from a sequence that can act as a substrate for Rep endonucleolytic activity [terminal resolution site (TRS)]. Mutations in either the AAVS1-encoded RBS or TRS elements abort targeted integration. Since both the RBS and TRS elements are present in the viral origin of replication and are required for AAV replication, targeted integration into chromosome 19 AAVS1 DNA may involve a replicative type of recombination that is discussed. An additional chromosome 19 element, which is responsible for DNA rearrangements in episomes propagating AAVS1 DNA, was identified and shown not to be required for AAV episomal integration, despite its location adjacent to the recombination signal.
Nondestructive Bridge Deck Testing with Air-Coupled Impact-Echo and Infrared Thermography (2011)

Two different nondestructive test (NDT) methods, air-coupled impact-echo (IE) and infrared (IR) thermography are evaluated on a full-scale simulated reinforced concrete bridge deck containing simulated delamination and cracking defects. The IE data are presented as two-dimensional frequency maps and spectral B-scan lines. The IR data are presented as temperature maps on the concrete surface. The lateral boundaries of the detected delaminations are also indicated in the images. The results obtained from each of the individual NDT methods show reasonably good agreement with most of the actual defects. The advantages and limitations of each method to characterize defects are discussed. The consistency and sensitivity of each method are also investigated. Finally, a simple data fusion technique is proposed to improve effectiveness of the individual test data. The findings from this study demonstrate that the combination of air-coupled IE and IR thermography tests is a practical option for consistent and rapid in situ evaluation of reinforced concrete bridge decks.
Three‐dimensional volumetric quantification of fat loss following cryolipolysis (2013)

Cryolipolysis is a safe, well-tolerated, and effective noninvasive fat removal methodology that on average leads to 39.6 cc of fat loss of the treated flank at 2 months after a single treatment cycle.
Ultraviolet Ca K-line narrow-bandwidth imaging filters based on holographic Bragg gratings in photorefractive materials (1997)

Current narrow-band optical filters for professional solar astronomy applications are primarily based on Lyot filters.1 However, the Lyot filter is severely limited in operation at UV wavelengths because of the lack of suitable UV hightransmission polarizers. In addition, the Lyot filter is comprised of over 50 elements ~over 30 cm long and weighing several kilograms! that require precise alignment and temperature stabilization for all of the elements.
Identification of a specific receptor for erythroid differentiation factor on follicular granulosa cell. (1988)

A cellular receptor for erythroid differentiation factor (EDF) was demonstrated by incubation of 125I-labeled EDF with rat follicular granulosa cell cultures. The specific binding of labeled EDF to the cells showed saturation; Scatchard analysis of binding data indicated a single class of receptors having Kd = 3.4 x 10(-10) M. A large excess of unlabeled EDF reduced labeled EDF binding almost completely, whereas similar doses of inhibin and transforming growth factor type beta, which are quite similar to EDF in protein structure and subunit organization, had no effect; EDF did not share receptors with those factors. EDF receptor (activin A receptor) expression was enhanced in granulosa cells cultured in the presence of follicle-stimulating hormone; follicle-stimulating hormone raised the number of EDF binding sites/cell from 13,000 to 96,000 without altering the binding affinity.
High-resolution structure of RNase P protein from Thermotoga maritima (2003)

The structure of RNase P protein from the hyperthermophilic bacterium Thermotoga maritima was determined at 1.2-A resolution by using x-ray crystallography. This protein structure is from an ancestral-type RNase P and bears remarkable similarity to the recently determined structures of RNase P proteins from bacteria that have the distinct, Bacillus type of RNase P. These two types of protein span the extent of bacterial RNase P diversity, so the results generalize the structure of the bacterial RNase P protein. The broad phylogenetic conservation of structure and distribution of potential RNA-binding elements in the RNase P proteins indicate that all of these homologous proteins bind to their cognate RNAs primarily by interaction with the phylogenetically conserved core of the RNA. The protein is found to dimerize through an extensive, well-ordered interface. This dimerization may reflect a mechanism of thermal stability of the protein before assembly with the RNA moiety of the holoenzyme.
Notch3 signalling promotes tumour growth in colorectal cancer (2011)

Increased Notch1 activity has been observed in intestinal tumours, partially accomplished by β-catenin-mediated up-regulation of the Notch ligand Jagged-1. Whether further mechanisms of Notch activation exist and other Notch receptors might be involved is unclear. Microarray data indicated that Notch3 transcript levels are significantly up-regulated in primary and metastatic CRC samples compared to normal mucosa. Moreover, Notch3 protein was expressed at strong/moderate levels by 19.7% of 158 CRC samples analysed, and at weak levels by 51.2% of the samples. Intrigued by these findings, we sought to investigate whether Notch3 modulates oncogenic features of CRC cells. By exploiting xenografts of CRC cells with different tumourigenic properties in mice, we found that the aggressive phenotype was associated with altered expression of components of the Notch pathway, including Notch3, Delta-like 4 (DLL4), and Jagged-1 ligands. Stimulation with immobilized recombinant DLL4 or transduction with DLL4-expressing vectors dramatically increased Notch3 expression in CRC cells, associated with accelerated tumour growth. Forced expression of an active form of Notch3 mirrored the effects of DLL4 stimulation and increased tumour formation. Conversely, attenuation of Notch3 levels by shRNA resulted in perturbation of the cell cycle followed by reduction in cell proliferation, clonogenic capacity, and inhibition of tumour growth. Altogether, these findings indicate that Notch3 can modulate the tumourigenic properties of CRC cells and contributes to sustained Notch activity in DLL4-expressing tumours.
A Reflectance Model for Computer Graphics (1982)

article Free AccessA Reflectance Model for Computer Graphics Share on Authors: R. L. Cook Lucasfilm Ltd., P.O. Box 2009, San Rafael, CA Lucasfilm Ltd., P.O. Box 2009, San Rafael, CAView Profile , K. E. Torrance Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NYView Profile Authors Info & Claims ACM Transactions on GraphicsVolume 1Issue 1Jan. 1982 pp 7–24https://doi.org/10.1145/357290.357293Online:01 January 1982Publication History 810citation7,671DownloadsMetricsTotal Citations810Total Downloads7,671Last 12 Months339Last 6 weeks53 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Intravitreal Methotrexate as an Adjunctive Treatment of Intraocular Lymphoma (1997)

Survival rates and time to relapse for patients with primary central nervous system lymphoma have improved. The role of ocular radiation therapy must be weighed against the potential drawbacks. Injecting chemotherapeutic agents into the vitreous is worthy of consideration. Four patients treated to date at our institution have had promising results. Intravitreal chemotherapy may result in improved treatment of intraocular lymphoma with reduced morbidity.
Dielectrophoretic ratchets (1998)

We have experimentally applied some concepts of "force-free" motion to micron size particles (latex beads). The coupling of dissipation and local spatial asymmetry of the potential experienced by the beads can put them into motion. The potentials used in these experiments are of dielectrophoretic nature. To that end, electrodes of particular shapes were used in order to submit the considered suspensions to inhomogeneous ac electric fields. Two regimes were explored: i-the Brownian ratchet case in which a Brownian particle is successively trapped in a factory roof-like potential and left free to diffuse. ii-the shifted ratchets case in which two potentials exhibiting similar characteristics are applied successively, one of them being shifted by a fraction of their common period relatively to the other. In both cases, a good agreement with the theoretical predictions was observed. In particular, particles of different sizes were characterized by different macroscopic velocities leading to the prospect of promising separation techniques. (c) 1998 American Institute of Physics.
Studies on the Synthesis of New 3‐(3,5‐Diamino‐1‐substituted‐pyrazol‐4‐yl)azo‐thieno[2,3‐b]pyridines and 3‐(2‐Amino‐5,7‐disubstituted‐pyrazolo[1,5‐a]pyrimidine‐3‐yl)azothieno[2,3‐b]pyridines (1999)

Abstract Coupling the diazonium salt of 3‐amino‐2‐cyano‐4,6‐dimethylthieno[2,3‐ b ]pyridine 1 with malononitrile 2 gave 2‐cyano‐3‐(hydrazonomalononitrile)‐4,6‐dimethylthieno[2,3‐ b ]pyridine 3 which then reacted with hydrazine compounds 4a‐4h to yield corresponding 2‐cyano‐3‐(3,5‐diamino‐1‐substituted‐pyrazol‐4‐yl)azo‐4,6‐dimethylthieno[2,3‐ b ]pyridines 5a‐5h. The 2‐cyano‐3‐(2‐amino‐5,7‐disubstituted‐pyrazolo‐[1,5‐ a ]pyrimidine‐3‐yl)azo‐4,6‐dimethylthieno[2,3‐ b ]pyridines 7a‐7f were obtained in good yield by the cyclocondensation reaction of 2‐cyano‐3‐(3,5‐diamino‐pyrazol‐4‐yl)azo‐4,6‐dimethylthieno[2,3‐ b ]pyridine 5a with the appropriate 1,3‐diketones 6a‐6f under acidic condition.
Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values (2007)

When the calibration of S(cr) methods is traceable to the S(cr) reference system, GFR should be estimated using the MDRD Study equation that has been reexpressed for standardized S(cr).
Twilight-zone and canopy shade induction of the Athb-2 homeobox gene in green plants. (1996)

We present evidence that a novel phytochrome (other than phytochromes A and B, PHYA and PHYB) operative in green plants regulates the "twilight-inducible" expression of a plant homeobox gene (Athb-2). Light regulation of the Athb-2 gene is unique in that it is not induced by red (R)-rich daylight or by the light-dark transition but is instead induced by changes in the ratio of R to far-red (FR) light. These changes, which normally occur at dawn and dusk (end-of-day FR), also occur during the daytime under the canopy (shade avoidance). By using pure light sources and phyA/phyB null mutants, we demonstrated that the induction of Athb-2 by changes in the R/FR ratio is mediated for the most part by a novel phytochrome operative in green plants. Furthermore, PHYB plays a negative role in repressing the accumulation of Athb-2 mRNA in the dark and a minor role in the FR response. The strict correlation of Athb-2 expression with FR-induced growth phenomena suggests a role for the Athb-2 gene in mediating cell elongation. This interpretation is supported by the finding that the Athb-2 gene is expressed at high levels in rapidly elongating etiolated seedlings. Furthermore, as either R or FR light inhibits cell elongation in etiolated tissues, they also down-regulate the expression of Athb-2 mRNA. Thus, these data support the notion that changes in light quality perceived by a novel phytochrome regulate plant development through the action of the Athb-2 homeobox gene.
Liver Transplantation Today (1989)

Clinical liver transplantation has been performed for more than 25 years. In the 1980s the survival has markedly improved as a result of better patient selection, improved operative techniques, and better understanding of rejection and immunosuppression. This review examines the improvements in liver transplantation that have led to one-year patient survival rates of better than 80%.
THE TIME EFFECT OF SUSPENSION ON THE BEHAVIOUR OF PIERS (1976)

COMPARATIVE LOAD TESTS WERE CARRIED OUT ON TWO PIERS OF RECTANGULAR CROSS SECTION 0.4 X 2.2 M CONSTRUCTED IN DANUBE GRAVEL-SAND TO A DEPTH OF 6 M BY MEANS OF THE SLURRY TRENCH TECHNIQUE. IN THE CONSTRUCTION OF EACH PIER THE SAME METHOD AND MATERIALS WERE USED WITH THE EXCEPTION OF THE TIME OF EFFECTIVENESS OF THE SUSPENSION. THE AVERAGE TIME OF EFFECTIVENESS OF THE SUSPENSION ON THE FOUNDATION SOIL WAS EIGHT HOURS IN THE CASE OF PIER P1 AND NINETY SEVEN HOURS (4 DAYS) IN THE CASE OF PIER P2. EQUIPPING OF THE PIERS WITH STRAIN GAUGES FOR MEASURING LATERAL MOVEMENTS MADE IT POSSIBLE TO CONFIRM THE VITAL INFLUENCE OF THE TIME OF EFFECTIVENESS OF THE SUSPENSION BOTH ON THE SKIN FRICTION AND ALSO ON THE END REACTION. THE COVERING ABSTRACT FOR THE CONFERENCE IS IRRD NO 306088.
A phase II evaluation of goserelin and bicalutamide in patients with ovarian cancer in second or higher complete clinical disease remission (2007)

The use of goserelin and bicalutamide did not appear to prolong PFS in patients with epithelial ovarian cancer in second or greater complete disease remission. The number of patients in disease remission at given time points may serve as a clinical trial endpoint for future studies of consolidation therapy.
Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss (1999)

All vertebrates have an egg shell that surrounds ovulated eggs and plays critical roles in gamete recognition. This extracellular matrix is known as the zona pellucida in eutherian mammals and consists of three glycoproteins, ZP1, ZP2 and ZP3 in the mouse. To investigate the role of ZP1 in fertilization and early development, we have used targeted mutagenesis in embryonic stem cells to create mouse lines (Zp1(tm/tm)) lacking ZP1. Although a zona pellucida composed of ZP2 and ZP3 was formed around growing Zp1(tm/tm) oocytes, the matrix was more loosely organized than zonae around normal oocytes. In some Zp1 null follicles, this structural abnormality resulted in ectopic clusters of granulosa cells, lodged between the zona matrix and the oolemma, that perturbed normal folliculogenesis. Comparable numbers of eggs were ovulated from Zp1 null females and normal females following hormonal stimulation. However, after mating with males, fewer two-cell embryos were recovered from Zp1 null females, and their litters were significantly smaller than those produced by normal mice. Therefore, although mouse ZP1 is not essential for sperm binding or fertilization, it is required for the structural integrity of the zona pellucida to minimize precocious hatching and reduced fecundity.
Degeneration and the chemical composition of the human lumbar intervertebral disc (1987)

Fifteen lumbar spines were collected postmortem. The intervertebral discs were assigned morphological grades and were analyzed for water, collagen, and proteoglycan. In order of increasing degeneration, five grade 0, four grade 1, 45 grade 2, 12 grade 3A, and nine grade 3B discs were identified. The proteoglycan concentration fell progressively with increasing grade, although the concentrations of each component overlapped extensively among the grades. Grade 2 discs showed no consistent differences from adjacent grade 3A or 3B discs in the same spine. All discs in seven of the eight spines with grade 3A or 3B discs and all discs in three spines with no grade 3A or 3B discs had proteoglycan concentrations below 52 mg/g fresh weight. Four of five spines with at least one disc of proteoglycan concentration above this value contained no grade 3A or 3B discs. These observations support the hypothesis that low proteoglycan concentrations in all the discs of a spine precede degeneration.
Direct current glow discharges in atmospheric air (1999)

Direct current glow discharges have been operated in atmospheric air by using 100 μm microhollow cathode discharges as plasma cathodes. The glow discharges were operated at currents of up to 22 mA, corresponding to current densities of 3.8 A/cm2 and at average electric fields of 1.2 kV/cm. Electron densities in the glow are in the range from 1012 to 1013 cm−3. Varying the current of the microhollow cathode discharge allows us to control the current in the atmospheric pressure glow discharge. Large volume atmospheric pressure air plasmas can be generated by operating microhollow cathode discharges in parallel.
Management of traumatic war wounds using vacuum-assisted closure dressings in an austere environment. (2010)

An effective protocol utilizing VAC dressings was developed for the expeditious treatment of traumatic war injuries in an austere environment.