gebhart/patrepeval huggingface dataset:
Combinations of drugs in the Treatment of Obesity (2010)

Obesity is a chronic disease associated with excess morbidity and mortality. Clinical treatment, however, currently offers disappointing results, with very high rates of weight loss failure or weight regain cycles, and only two drugs (orlistat and sibutramine) approved for long-term use. Drugs combinations can be an option for its treatment but, although widely used in clinical practice, very few data are available in literature for its validation. Our review focuses on the rationale for their use, with advantages and disadvantages; on combinations often used, with or without studies; and on new perspectives of combinations being studied mainly by the pharmaceutical industry.
Alkylation of Synthetic Polynucleotides (1964)

The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci (2001)

Aberrant DNA methylation is believed to be important in tumorigenesis by causing either transcriptional inactivation of genes or chromosomal instability. Several laboratories have identified promoter hypermethylation of tumor suppressor genes in acute myeloid leukemia (AML). However, these studies do not provide a global assessment of overall methylation changes and do not allow the identification of novel methylated sequences. Previously, nonrandom CpG island methylation was reported in 17 adult de novo AML diagnostic samples when compared with the corresponding remission samples by means of restriction landmark genomic scanning (RLGS). That study has been expanded on by an analysis of a larger set of CpG islands (1740 vs 1184), which now provides details of 33 cloned methylated loci, including 21 known genes or expressed sequence tags. Five of these cloned loci appear to be methylated only in AML and not in the 6 solid tumors studied in this study (more than 98 samples analyzed). Chromosomal location was available for 30 of the 33 loci, and 5 of these 30 (17%) are localized to chromosome 11, suggesting a trend toward overrepresentation of methylation events on this chromosome. These results provide evidence for widespread aberrant methylation in AML, with identification of novel methylation targets, epigenetic changes that appear unique to AML, and apparent preferential methylation on chromosome 11.
Cytokine-induced killer cells are type II natural killer T cells. (2007)

We conclude that CIK cells do not belong to the type I NKT cells.
Negative bias temperature instability: Road to cross in deep submicron silicon semiconductor manufacturing (2003)

We present an overview of negative bias temperature instability (NBTI) commonly observed in p-channel metal–oxide–semiconductor field-effect transistors when stressed with negative gate voltages at elevated temperatures. We discuss the results of such stress on device and circuit performance and review interface traps and oxide charges, their origin, present understanding, and changes due to NBTI. Next we discuss the effects of varying parameters (hydrogen, deuterium, nitrogen, nitride, water, fluorine, boron, gate material, holes, temperature, electric field, and gate length) on NBTI. We conclude with the present understanding of NBTI and its minimization.
Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. (1997)

Accumulating evidence indicates that endothelial cell integrins that bind to the matrix proteins associated with inflammation and wound healing are involved in the process of angiogenesis. The integrins containing the alpha v subunit appear to be particularly important. To study the involvement of these receptors in human angiogenesis, a model of wound-associated human angiogenesis was established in human skin transplanted onto severe combined immunodeficient (SCID) mice. Using this model, we studied the expression of several alpha v integrins and tested the hypothesis that blockage of the alpha v beta 3 integrin would inhibit human angiogenesis during human wound healing. These studies revealed that the alpha v beta 3, alpha v beta 5, and alpha v beta 6 integrins are up-regulated briefly during wound angiogenesis with different patterns of expression and that inhibition of the alpha v beta 3 integrin blocked new vessel formation during human wound healing.
Inviting Consumers To Downsize Fast-Food Portions Significantly Reduces Calorie Consumption (2012)

Policies that mandate calorie labeling in fast-food and chain restaurants have had little or no observable impact on calorie consumption to date. In three field experiments, we tested an alternative approach: activating consumers' self-control by having servers ask customers if they wanted to downsize portions of three starchy side dishes at a Chinese fast-food restaurant. We consistently found that 14-33 percent of customers accepted the downsizing offer, and they did so whether or not they were given a nominal twenty-five-cent discount. Overall, those who accepted smaller portions did not compensate by ordering more calories in their entrées, and the total calories served to them were, on average, reduced by more than 200. We also found that accepting the downsizing offer did not change the amount of uneaten food left at the end of the meal, so the calorie savings during purchasing translated into calorie savings during consumption. Labeling the calorie content of food during one of the experiments had no measurable impact on ordering behavior. If anything, the downsizing offer was less effective in changing customers' ordering patterns with the calorie labeling present. These findings highlight the potential importance of portion-control interventions that specifically activate consumers' self-control.
On the number of internal and external visibility edges of polygons. (1997)

In six children with body weights between 11.4-18.7 kg, minute ventilation, tidal volume, respiratory rate, end-tidal CO2 concentration and CO2 elimination were measured during both CO2 free breathing and CO2 breathing due to low fresh gas flows (maximal inspired CO2 about 2%) or the addition of CO2 from Rotameters (mean inspired CO2 about 1.5%) during both halothane and enflurane anaesthesia. All patients were undergoing hypospadias repair, received caudal analgesia prior to surgery and were intubated and allowed to breathe halothane/enflurane in O2/N2O (FIO2 0.5) spontaneously through a modified T-piece system (Mapleson F). End-tidal CO2 concentrations were similar with both agents during CO2-free breathing and did not increase during CO2 breathing because of increased minute ventilation, of the same magnitude with both agents, which was achieved by larger tidal volumes. Respiratory rates were unchanged. No differences were found between halothane and enflurane at the light levels of general anaesthesia made possible by combination with caudal block.
Marking and Gene Expression by a Lentivirus Vector in Transplanted Human and Nonhuman Primate CD34+Cells (2000)

Recently, gene delivery vectors based on human immunodeficiency virus (HIV) have been developed as an alternative mode of gene delivery. These vectors have a number of advantages, particularly in regard to the ability to infect cells which are not actively dividing. However, the use of vectors based on human immunodeficiency virus raises a number of issues, not the least of which is safety; therefore, further characterization of marking and gene expression in different hematopoietic lineages in primate animal model systems is desirable. We use two animal model systems for gene therapy to test the efficiency of transduction and marking, as well as the safety of these vectors. The first utilizes the rhesus animal model for cytokine-mobilized autologous peripheral blood CD34(+) cell transplantation. The second uses the SCID-human (SCID-hu) thymus/liver chimeric graft animal model useful specifically for human T-lymphoid progenitor cell reconstitution. In the rhesus macaques, detectable levels of vector were observed in granulocytes, lymphocytes, monocytes, and, in one animal with the highest levels of marking, erythrocytes and platelets. In transplanted SCID-hu mice, we directly compared marking and gene expression of the lentivirus vector and a murine leukemia virus-derived vector in thymocytes. Marking was observed at comparable levels, but the lentivirus vector bearing an internal cytomegalovirus promoter expressed less efficiently than did the murine retroviral vector expressed from its own long terminal repeats. In assays for infectious HIV type 1 (HIV-1), no replication-competent HIV-1 was detected in either animal model system. Thus, these results indicate that while lentivirus vectors have no apparent deleterious effects and may have advantages over murine retroviral vectors, further study of the requirements for optimal use are warranted.
Multi-sensor location tracking (1998)

In order to support location-aware apphcations it is necessary to locate people and equipment in near rerd-time.
The Influence of the Pool of Candidates on the Performance of Selection and Combination Techniques in Ensembles (2006)

In this paper, we propose the use of an immune-inspired approach called opt-aiNet to generate a diverse set of high-performance candidates to compose an ensemble of neural network classifiers. Being a population-based search algorithm, the opt-aiNet is capable of maintaining diversity and finding many high-performance solutions simultaneously, which are known to be desired features when synthesizing an ensemble. Concerning the selection and combination phases, the most relevant selection and combination techniques already proposed in the literature have been considered. The main contribution of this paper is the indication that there is no pair of selection/combination technique that can be considered the best one, because the performance of the obtained ensemble varies significantly with the current composition of the pool of candidates already produced by the generation phase. Notwithstanding, this variability in performance is not restricted to the choice of opt-aiNet as the generative device. As a consequence, to overcome the performance of the best individual classifier, every possible pairs of selection and combination techniques should be tried. Only with such an exhaustive search (notice that the main computational burden is usually related to the generation phase), the performance of the ensemble was invariably superior to the performance of the best individual classifier on four benchmark classification problems.
Evolution of Intracerebral Hemorrhage after Intravenous Tpa: Reversal of Harmful Effects with Mast Cell Stabilization (2013)

Thrombolysis with tissue plasminogen activator (tPA) traditionally demands baseline imaging to rule out intracerebral hemorrhage (ICH), which causes delays in treatment. Preventing possible adverse effects of tPA on ICH would allow rapid on-site thrombolysis in patients with presumed acute ischemic stroke, reducing onset-to-treatment times. We examined how intravenous tPA alters ICH evolution during an extended follow-up, and how mast cell stabilization affects this process. Intracerebral hemorrhage was induced in rats by collagenase injection. Rats received either saline (n=10), tPA (n=13), tPA+low-dose cromoglycate (n=10), or tPA+high-dose cromoglycate (n=10). Magnetic resonance imaging was performed at 24, 48, and 72 hours after ICH induction, together with neurologic evaluations. During 72 hours of follow-up, tPA administration did not significantly increase hematoma volume (mean±s.d. 83.5±14.3 versus 66.7±14.7 μL; P=0.256) or hemispheric expansion (14.5±5.0 versus 11.5±5.0%; P=0.457) compared with saline. However, tPA-treated animals had worse neurologic outcomes (P<0.05), and mortality (8/13 versus 3/10). Combining tPA with high-dose cromoglycate mitigated hemispheric expansion (7.4±1.7 versus 14.5±5.0%; P=0.01), improved neurologic outcome (P<0.001) and decreased mortality (1/10; P<0.05) compared with tPA alone. Our results suggest tPA increases neurologic deficit in ICH, an effect that was abolished by concomitant mast cell stabilization. Further studies are needed to establish the clinical relevance of these findings.
P1–448: True healing art of Alzheimer's by holistic homeopathy (2006)

Homeopathic theory The highest ideal of cure is rapid, gentle and permanent restoration of health, or removal and annihilation of the disease in its whole extent, in the shortest, most reliable, and harmless way, on easily comprehensible principle. Homeopathy offers reasonably positive treatment not cure but control and relief. Timely administered homeopathy medicines can prevent further progress of disease. The homeopathic remedies work by stimulating the body's own healing power. Homeopathy the holistic approach believes in treating the patient who is diseased and not merely diseased parts of the patients. Every person is unique and dementia affects people differently no two people will follow exactly the same course and the homeopathy the ultimate pathy in the world believes in individuality of the person has been shown to have a positive impact on the progress of the disease. Homeopathy undertakes study of each Alzheimer's as separate entity. The study also involves deep evaluation of the mind and emotions and after that a suitable medicine, called as constitutional medicine is given. The medication brings deeper level healing. It should be noted that there is no single specific remedy for all the cases of Alzheimer's. The exact treatment is determined only on in–depth evaluation of individual case.
Identification and characterization of a hormonally regulated form of phospholipase A2 in rat renal mesangial cells. (1988)

The activity of phospholipase A2 (PLA2), the regulatory enzyme in arachidonic acid release and prostaglandin synthesis, was measured in cell-free extracts of rat renal mesangial cells. Arginine vasopressin (AVP) and phorbol myristate acetate (PMA) both stimulated PLA2 activity as assayed by the release of free arachidonic acid from exogenously added [14C]arachidonyl-phosphatidylcholine. This represents a direct in vitro demonstration of hormone-induced changes in PLA2 activity. The stimulated activity was recovered following fractionation by DEAE-cellulose anion exchange and FPLC Superose 12 gel filtration. Stimulated activity from AVP- and PMA-treated cells comigrated as a single peak, suggesting that these agents are stimulating a single form of the enzyme. The molecular weight of this hormonally regulated form of PLA2 is approximately 60,000. The enzyme has an obligate requirement for Ca2+, having no activity in the presence of EGTA, and has a pH optimum in the alkaline range. Following cell disruption in the presence of chelators, the enzyme is recovered in a high speed supernatant. However, it appears that it can bind to a crude membrane fraction in a Ca2+-dependent manner, similar to other Ca2+-phospholipid binding proteins. The observed stable modification in PLA2 activity by AVP and PMA suggests a phosphorylation of PLA2 or PLA2 modulators by protein kinase C.
The Use Of Trifluoroacetic Anhydride And Related Compounds In Organic Syntheses (1955)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTThe Use Of Trifluoroacetic Anhydride And Related Compounds In Organic SynthesesJ. M. TedderCite this: Chem. Rev. 1955, 55, 5, 787–827Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October 1955https://pubs.acs.org/doi/10.1021/cr50005a001https://doi.org/10.1021/cr50005a001research-articleACS PublicationsRequest reuse permissionsArticle Views2217Altmetric-Citations84LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Designing service-independent capabilities for intelligent networks (1988)

A key attribute desired of intelligent networks is the ability to design multiple services from a set of service-independent capabilities. Some aspects of the planning, requirements specification, design. and development processes to produce such capabilities are examined. Important factors and considerations necessary to the successful realization of service independence are described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
N-Acetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilation* (2011)

These data show that the administration of N-acetylcysteine protects the diaphragm from the deleterious effects of controlled mechanical ventilation. Specifically, N-acetylcysteine prevents against controlled mechanical ventilation-induced diaphragmatic oxidative stress and proteolysis and abolishes controlled mechanical ventilation-induced diaphragmatic contractile dysfunction.
Double-Resonance Plasmon Substrates for Surface-Enhanced Raman Scattering with Enhancement at Excitation and Stokes Frequencies (2010)

We report a surface-enhanced Raman scattering (SERS) substrate with plasmon resonances at both excitation and Stokes frequencies. This multilayer structure combines localized surface plasmons on the nanoparticles with surface plasmon polaritons excited on a gold film. The largest SERS enhancement factor for a gold device is measured to be 7.2 x 10(7), which is more than 2 orders of magnitude larger than that measured on a gold nanoparticle array on a glass substrate. The largest SERS enhancement for a silver device is measured to be 8.4 x 10(8).
Vascular endothelial growth factor B, a novel growth factor for endothelial cells. (1996)

We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle.
Review article (1997)

Hypocrisy and Dissent within the Findhorn Foundation: Towards a Sociology of a New Age Community Stephen J. Castro, 1996 Forres: New Media Books 240 pp., appendix, index, £9.95 (pb) ISBN 0–9526881–0–7
A simple method to determine the floating-body voltage of SOI CMOS devices (2000)

A technique to extract the off-state floating-body (FB) voltage of silicon-on-insulator (SOI) CMOS devices is presented. The bias dependent S-parameter measurements of a single standard FB SOI device and its equivalent circuit, along with the capacitance-voltage (C-V) measurements between the drain and source of the same device, are used to determine the FB voltage. No special test structure design is needed. The technique proposes a method for the extraction of the parasitic source, drain, and gate resistances. Using the technique, FB voltage in excess of 0.4 V is measured in a partially depicted (PD) NMOS device at drain voltage of 2.5 V and zero gate voltage.
Naturally occurring linear fused thiazoline-thiazole containing metabolites: total synthesis of (–)-didehydromirabazole A, a cytotoxic alkaloid from blue–green algae (1993)

A concise total synthesis of the thiazoline-thiazole containing metabolite didehydromirabazole A 1 is described. The synthesis uses the unusual amino acid (R)-2-methylcysteine 20 in sequential cyclocondensations with imino ethers as key steps, viz22→32 and 37→38.
Motion compensated fiber-optic confocal microscope based on a common-path optical coherence tomography distance sensor (2011)

A motion compensated fiber-optic confocal microscope system is demonstrated by utilizing a Fourier domain common-path optical coherence tomography (FD-CP-OCT) distance sensor and a high-speed linear motor at the distal end of a fiber-optic confocal microscope imaging probe. The fiber-optic confocal microscope is based on a 460 μm diameter imaging bundle with 10 K cores. The fiber bundle was terminated with a gradient index lens system. Using one-dimensional A-scan data of CP-OCT, the distance deviation of the target from the focal plane of the probe was monitored and motion compensated at the rate of 840 Hz, for a confocal microscopic imaging frame rate of 1fps and was 200 × 200 pixels in size, with a distance error less than 5 μm.
Neurogenic inflammation and reflex sympathetic dystrophy (in vivo and in vitro assessment in an experimental model). (1998)

In the chronic constriction injury (CCI) model, signs and symptoms similar to those observed in reflex sympathetic dystrophy (RSD) can be induced by loosely ligating a rat sciatic nerve. Skin microcirculatory (inflammation-like) disorders may result from release of vasoactive neuropeptides at peripheral endings of antidromically acting nociceptive nerve fibers. These antidromic mechanisms may account for vasodilation and polymorphonuclear leukocyte (PMN) accumulation in the ligated hindpaw. We assessed skin blood flow (SBF) on the ligated side, by means of laser Doppler flowmetry, before as well as at day 4 after ligation. Postligation SBF measurements were performed before and after selective (capsaicin) conduction blockade of the ligated sciatic nerve. The extent of PMN accumulation was determined by measuring myeloperoxidase (MPO) activity in muscle biopsies obtained from the ligated and contralateral nonligated side. As compared to preligation SBF values, we observed an increase at day 4. SBF returned to preligation values consequent to capsaicin application. MPO activity, when compared to the nonligated side, was higher in biopsies obtained from the ligated side. These findings indicate that in the CCI-model, antidromically acting C-nociceptor nerve fibres increase SBF at 4 days after ligation. In addition, these antidromic mechanisms may induce an inflammatory response in the ipsilateral hindpaw, mediated by release of neuropeptides from the peripheral endings of antidromically acting C-nociceptor nerve fibers. This inflammatory response may account for various signs and symptoms as observed in the CCI model and may mirror pathophysiological mechanisms of RSD.