gebhart/patrepeval huggingface dataset:
Partial resolution of racemic tertiary phosphines with an asymmetric palladium complex (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial resolution of racemic tertiary phosphines with an asymmetric palladium complexSeinosuke Otsuka, Akira Nakamura, Tosizi Kano, and Kazuhide TaniCite this: J. Am. Chem. Soc. 1971, 93, 17, 4301–4303Publication Date (Print):August 1, 1971Publication History Published online1 May 2002Published inissue 1 August 1971https://pubs.acs.org/doi/10.1021/ja00746a041https://doi.org/10.1021/ja00746a041research-articleACS PublicationsRequest reuse permissionsArticle Views454Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disposition of Mesalazine from Mesalazine-Delivering Drugs in Patients with Inflammatory Bowel Disease, with and without Diarrhoea (1992)

The disposition of mesalazine from the azo compounds sulphasalazine and olsalazine (Dipentum) and from the slow-release mesalazine drugs Pentasa, Asacol, and Salofalk was studied in 20 patients with inflammatory bowel disease. Ten of them had diarrhoea, and 10 had normal stools. On the last 2 days of a 7-day maintenance treatment with each of the study drugs urine and faeces were collected for determination of mesalazine, acetyl-mesalazine, and unsplit azo compound. In patients with and without diarrhoea the urinary and the faecal excretion of acetyl-mesalazine was lowest during treatment with olsalazine. The proportion of acetyl-mesalazine in faeces was highest during treatment with Pentasa in both groups. The presence of diarrhoea was associated with a decrease in the proportion of acetyl-mesalazine in faeces during treatment with all drugs, not significant only for Pentasa. The proportion of unsplit azo compound in faeces increased in the case of diarrhoea to almost 50%. It is concluded that in patients with inflammatory bowel disease diarrhoea substantially influences the disposition from all these drugs except Pentasa.
Frequency estimation precision in Doppler optical coherence tomography using the Cramer-Rao lower bound (2005)

Doppler optical coherence tomography (DOCT) is a technique for simultaneous cross-sectional imaging of tissue structure and blood flow. We derive the fundamental uncertainty limits on frequency estimation precision in DOCT using the Cramer-Rao lower bound in the case of additive (e.g., thermal, shot) noise. Experimental results from a mirror and a scattering phantom are used to verify the theoretical limits. Our results demonstrate that the stochastic nature of frequency noise influences the precision of flow imaging, and that the noise model must be selected judiciously in order to estimate the frequency precision.
Tight Binding of a Dimeric Derivative of Vancomycin with Dimeric l-Lys-d-Ala-d-Ala (1997)

The ligand/receptor pair consisting of a synthetic dimeric derivative of vancomycin (V), linked at the C terminus by p-xylylenediamine (V-CONHCH2C6H4CH2NHCO-V), and a dimeric derivative of l-Lys-d-Ala-d-Ala, [CH2CONεH(Nα-Ac)-l-Lys-d-Ala-d-Ala-CO2-]2, provides a new system with which to study the influence of divalency on the strength of binding. A competitive assay using affinity capillary electrophoresis (ACE) has been developed and used to estimate the dissociation constant of the divalent complex (≈ 1.1 nM) and the enhancement in binding (∼103) relative to the corresponding monomeric interaction between unmodified monomeric vancomycin and diacetyl-l-Lys-d-Ala-d-Ala.
A New Type of Adenovirus Vector That Utilizes Homologous Recombination To Achieve Tumor-Specific Replication (2002)

We have developed a new class of adenovirus vectors that selectively replicate in tumor cells. The vector design is based on our recent observation that a variety of human tumor cell lines support DNA replication of adenovirus vectors with deletions of the E1A and E1B genes, whereas primary human cells or mouse liver cells in vivo do not. On the basis of this tumor-selective replication, we developed an adenovirus system that utilizes homologous recombination between inverted repeats to mediate precise rearrangements within the viral genome resulting in replication-dependent activation of transgene expression in tumors (Ad.IR vectors). Here, we used this system to achieve tumor-specific expression of adenoviral wild-type E1A in order to enhance viral DNA replication and spread within tumor metastases. In vitro DNA replication and cytotoxicity studies demonstrated that the mechanism of E1A-enhanced replication of Ad.IR-E1A vectors is efficiently and specifically activated in tumor cells, but not in nontransformed human cells. Systemic application of the Ad.IR-E1A vector into animals with liver metastases achieved transgene expression exclusively in tumors. The number of transgene-expressing tumor cells within metastases increased over time, indicating viral spread. Furthermore, the Ad.IR-E1A vector demonstrated antitumor efficacy in subcutaneous and metastatic models. These new Ad.IR-E1A vectors combine elements that allow for tumor-specific transgene expression, efficient viral replication, and spread in liver metastases after systemic vector application.
Purification and Properties of Dextransucrase from Streptococcus mutans (1974)

The dextransucrase (EC 2.4.1.5) activity from cell-free culture supernatants of Streptococcus mutans strain 6715 has been purified approximately 1,500-fold by ammonium sulfate precipitation, hydroxylapatite chromatography, and isoelectric focusing. The enzyme was eluted as a single peak of activity from hydroxylapatite, and isoelectric focusing of the resulting preparation gave a single band of dextransucrase activity which focused at a pH of 4.0. The final enzyme preparation contained two distinct, enzymatically active proteins as judged by assay in situ after polyacrylamide gel electrophoresis. One of the proteins represented 90% of the total dextransucrase activity and 53% of the total protein. The molecular weight of the enzyme was estimated by gel filtration to be 94,000. The temperature optimum of the enzyme was broad (34 to 42 C) and its pH range was rather narrow, with optimal activity at pH 5.5. The K(m) for sucrose was 3 mM, and fructose competitively inhibited the enzyme reaction with a K(i) of 27 mM.
Winnowing (2003)

Digital content is for copying: quotation, revision, plagiarism, and file sharing all create copies. Document fingerprinting is concerned with accurately identifying copying, including small partial copies, within large sets of documents.We introduce the class of local document fingerprinting algorithms, which seems to capture an essential property of any finger-printing technique guaranteed to detect copies. We prove a novel lower bound on the performance of any local algorithm. We also develop winnowing, an efficient local fingerprinting algorithm, and show that winnowing's performance is within 33% of the lower bound. Finally, we also give experimental results on Web data, and report experience with MOSS, a widely-used plagiarism detection service.
A Combination of Chemoimmunotherapies Can Efficiently Break Self-Tolerance and Induce Antitumor Immunity in a Tolerogenic Murine Tumor Model (2007)

Her-2/neu is a well-characterized tumor-associated antigen overexpressed in human carcinomas such as breast cancer. Because Her-2/neu is a self-antigen with poor immunogenicity due to immunologic tolerance, active immunotherapy targeting Her-2/neu should incorporate methods to overcome immunologic tolerance to self-proteins. In this study, we developed a tolerogenic tumor model in mice using mouse Her-2/neu as self-antigen and investigated whether genetic vaccination with DNA plasmid and/or adenoviral vector expressing the extracellular and transmembrane domain of syngeneic mouse Her-2/neu or xenogenic human Her-2/neu could induce mouse Her-2/neu-specific CTL responses. Interestingly, adenoviral vectors expressing xenogenic human Her-2/neu (AdhHM) proved capable of breaking immune tolerance and of thereby inducing self-reactive CTL and antibodies, but not to the degree required to induce therapeutic antitumor immunity. In attempting to generate therapeutic antitumor immunity against established tumors, we adopted several approaches. Treatment with agonistic anti-glucocorticoid-induced TNFR family-related receptor (GITR) antibody plus AdhHM immunization significantly increased self-reactive CTL responses, and alpha-galactosylceramide (alphaGalCer)-loaded dendritic cells (DC) transduced with AdhHM were shown to break self-tolerance in a tolerogenic murine tumor model. Furthermore, gemcitabine treatment together with either AdhHM plus agonistic anti-GITR antibody administration or alphaGalCer-loaded DC transduced with AdhHM showed potent therapeutic antitumor immunity and perfect protection against preexisting tumors. Gemcitabine treatment attenuated the tumor-suppressive environment by eliminating CD11b(+)/Gr-1(+) myeloid-derived suppressor cells. When combined with immunotherapies, gemcitabine offers a promising strategy for the Ag-specific treatment of human cancer.
Phenotype versus genotype in gliomas displaying inter- or intratumoral histological heterogeneity. (2003)

The gliomas in this study were more homogeneous in their genotype than their histological phenotype with regions of differing histological subtype indistinguishable by the genetic markers investigated, supporting a monoclonal origin of these tumors.
Real-Time Measurement of the Contractile Forces of Self-Organized Cardiomyocytes on Hybrid Biopolymer Microcantilevers (2005)

We present a microfabricated hybrid biopolymer microcantilever, in which the contractile force of self-organized cardiomyocytes can be measured and studied, as a prototype for the development of cell-driven actuators. The microcantilever is made of a flexible, transparent, biocompatible poly(dimethylsiloxane) substrate, using a simple microfabrication technique. Seeding and culturing cardiomyocytes on the specific cantilever allows us to perform highly sensitive, quantitative, and noninvasive measurement of the contractile force of the self-organized cells in real time. The motions of the microcantilever showed good agreement with an analytical solution based on Stoney's equation and finite element modeling (FEM) of the hybrid system. Immunostaining of the cells on the hybrid system showed continuous high-order coalignment of actin filaments and parallel sarcomeric organization in the direction of the longitudinal axis of the microcantilever without structural constraints, such as microgrooves or lines, and proved our FEM and the synchronous contraction of cardiomyocytes. The presented device should facilitate measurement of the contractile force of self-organized cardiomyocytes on a specific area, which may help the understanding of heart failure and the design of optimal hybrid biopolymer actuators, as well as assist development of a microscale cell-driven motor system.
Dynamics exploration and aggressive maneuvering of a Longitudinal Vectored Thrust VTOL aircraft (2011)

In this paper we introduce the model of a Longitudinal Vectored Thrust Vertical Take Off and Landing (LVT-VTOL) aircraft. We believe that the proposed model, while described by reasonably tractable equations, captures several interesting dynamic features of new generation vectored thrust aerial vehicles with new maneuvering capabilities as, in particular, the ability of vertical take off and landing and transition to a (classical) forward flight configuration. We characterize the equilibrium manifold of the LVT-VTOL in the entire range of operation (from hover to forward flight). Then, as main contribution of the paper, we propose an optimal control based strategy to explore the trajectory manifold (the set of possibly aggressive trajectories) of the proposed model. To show the effectiveness of the exploration strategy, we compute a full transition from hover to forward flight.
Integrated person tracking using stereo, color, and pattern detection (2002)

We present an approach to real-time person tracking in crowded and/or unknown environments using multi-modal integration. We combine stereo, color and face detection modules into a single robust system, and show an initial application in an interactive, face-responsive display. Dense, real-time stereo processing is used to isolate users from other objects and people in the background. Skin-hue classification identifies and tracks likely body parts within the silhouette of a user. Face pattern detection discriminates and localizes the face within the identified body parts. Faces and bodies of users are tracked over several temporal scales: short-term (user stay's within the field of view), medium-term (user exits/reenters within minutes), and long term (user returns after hours or days). Short-term tracking is performed using simple region position and size correspondences, while medium and long-term tracking are based on statistics of user appearance. We discuss the failure modes of each individual module, describe our integration method, and report results with the complete system in trials with thousands of users.
Reactive Oxygen Species Modulate Anopheles gambiae Immunity against Bacteria and Plasmodium (2007)

The involvement of reactive oxygen species (ROS) in mosquito immunity against bacteria and Plasmodium was investigated in the malaria vector Anopheles gambiae. Strains of An. gambiae with higher systemic levels of ROS survive a bacterial challenge better, whereas reduction of ROS by dietary administration of antioxidants significantly decreases survival, indicating that ROS are required to mount effective antibacterial responses. Expression of several ROS detoxification enzymes increases in the midgut and fat body after a blood meal. Furthermore, expression of several of these enzymes increases to even higher levels when mosquitoes are fed a Plasmodium berghei-infected meal, indicating that the oxidative stress after a blood meal is exacerbated by Plasmodium infection. Paradoxically, a complete lack of induction of catalase mRNA and lower catalase activity were observed in P. berghei-infected midguts. This suppression of midgut catalase expression is a specific response to ookinete midgut invasion and is expected to lead to higher local levels of hydrogen peroxide. Further reduction of catalase expression by double-stranded RNA-mediated gene silencing promoted parasite clearance by a lytic mechanism and reduced infection significantly. High mosquito mortality is often observed after P. berghei infection. Death appears to result in part from excess production of ROS, as mortality can be decreased by oral administration of uric acid, a strong antioxidant. We conclude that ROS modulate An. gambiae immunity and that the mosquito response to P. berghei involves a local reduction of detoxification of hydrogen peroxide in the midgut that contributes to limit Plasmodium infection through a lytic mechanism.
A review of the benefit–risk profile of gefitinib in Asian patients with advanced non‐small‐cell lung cancer (2006)

In the majority of these reports, objective response rates of > 25% and disease control rates of > 60% have been described. Treatment with gefitinib resulted in a median time to progression of > 3 months and a median survival time of > 6 months in most studies. These 31 reports also demonstrated the efficacy of gefitinib in patients with secondary brain metastases, those with poor performance status (PS) and in patients receiving the drug as first-line treatment. Female gender, adenocarcinoma histology, non-smoking history, good PS and the presence of multiple lung metastases are associated with improved responsiveness to gefitinib. Reflecting the results of previous clinical trials, the reports indicate that gefitinib is generally well tolerated by Asian patients. The incidence of interstitial lung disease appears to be higher in Japanese than non-Japanese patients, although the reasons for this are not clear. Recent findings regarding cellular and genetic factors that may underlie the increased responsiveness to gefitinib among Asian patients are discussed.
CD137‐Mediated T Cell Co‐Stimulation Terminates Existing Autoimmune Disease in SLE‐Prone NZB/NZW F1 Mice (2003)

T cell receptor recognition of antigen and major histocompatibility complex (signal 1) and T cell co-stimulation (signal 2) are essential for full T cell activation, differentiation, and survival of naïve and activated T cells. The proto-typical T cell co-stimulatory receptor, CD28, is a constitutively expressed type I integral transmembrane protein and member of the Ig superfamily. Since its discovery, additional T cell co-stimulatory receptors have been identified, a number of which belong to the tumor necrosis factor receptor superfamily. Included within this group is CD137 (4-1BB), an activation-inducible, type I transmembrane protein. Co-stimulation of T cells through CD137 effectively up-regulates CD8 T cell activation and survival. Although CD4(+) T cells are efficiently activated through the T cell receptor and CD137 receptor, it provokes CD4(+) T cell anergy and blockade of T-dependent humoral immune responses. Therefore, we tested whether agonistic anti-CD137 monoclonal antibodies (mAbs) would be effective in blocking the induction or progression of B cell dependent autoimmune disease. Herein, we demonstrate the protective effect of agonistic anti-CD137 mAbs in blocking systemic lupus erythematosus (SLE) disease progression in NZB/W F1 mice. Protection from SLE following anti-CD137 mAb treatment is not confined to rescuing mice from disease progression; rather, it fully protects young mice from developing any symptoms of disease. We further found that treatment of proteinuric mice with anti-CD137 blocks ongoing anti-dsDNA autoantibody production.
Structure, properties and applications of GexSi1-xstrained layers and superlattices (1991)

The first successful pseudomorphic GexSi1-x strained layers on Si were grown in Germany in 1975. The extensive work that has been done on the production, properties and application of GexSi1-x strained layers and superlattices over the last fifteen years is described in this review. Values of critical layer thickness of the strained layers predicted by equilibrium theories are discussed and compared with experimental results. For x<0.6 the observed values are much larger than the theoretical values. The possible causes of this discrepancy are investigated and it is concluded that the layers must be metastable due to an energy barrier for the production of dislocations. Critical layer thicknesses of superlattices are also discussed and symmetrically strained superlattices are described. Results of band structure calculations of the strained layers and superlattices are given. Strain causes a large reduction in the fundamental indirect band gap of the Si/Ge alloy. Calculated band line-ups at the strained layer-substrate interface are compared with experiment. Modifications in the band structure due to strain have considerable effect on the optical and transport properties of the strained layers. Observed luminescence, photoconductivity and mobility are compared with predictions, taking strain into account. In the case of superlattices, band structure is further modified by zone folding. Superlattice structures which can produce a direct band gap are discussed. Raman scattering has proved a valuable tool for characterizing strained layers and superlattices. In the case of GexSi1-x strained layers, the Raman spectrum shows phonon lines shifted by strain. In the case of superlattices, additional lines due to zone folded LA phonons are observed. Raman measurements may be used to determine strain, thickness of a period and quality of interfaces. This review places emphasis on the use of Si/Ge strained in layers in Si-technology-based integrated circuits. The devices which have been fabricated to exploit properties of these layers include double heterostructure bipolar transistors, optical detectors, modulation doped field-effect transistors and mixed tunnelling avalanche transit time diodes. Progress made in the last 18 months has been rapid; a transistor with a cut-off frequency of 75 GHz was recently fabricated and this device has considerable promise.
The ω‐3 epoxide of eicosapentaenoic acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin D1/CDK4 down‐regulation (2010)

The present findings suggest that the epoxide formed by CYP enzymes at the ω-3 olefinic bond may contribute to the beneficial effects of ω-3 PUFA by down-regulating cyclin D1 and suppressing cell proliferation.
Partial Transmit Sequences for Peak-to-Average Power Ratio Reduction in Multiantenna OFDM (2007)

The major drawback of orthogonal frequency-division multiplexing (OFDM) is its high peak-to-average power ratio (PAR), which gets even more substantial if a transmitter with multiple antennas is considered. To overcome this problem, in this paper, the partial transmit sequences (PTS) method—well known for PAR reduction in single antenna systems—is studied for multiantenna OFDM. A directed approach, recently introduced for the competing selected mapping (SLM) method, proves to be very powerful and able to utilize the potential of multiantenna systems. To apply directed PTS, various variants for providing a sufficiently large number of alternative signal superpositions (the candidate transmit signals) are discussed. Moreover, affording the same complexity, it is shown that directed PTS offers better performance than SLM. Via numerical simulations, it is pointed out that due to its moderate complexity but very good performance, directed or iterated PTS using combined weighting and temporal shifting is a very attractive candidate for PAR reduction in future multiantenna OFDM schemes.
Intralesional Injections of Triamcinolone (1963)

It is an established fact that intralesional injections of triamcinolone will result in temporary involution of most psoriatic lesions.<sup>1,2</sup>The purpose of this report is to note the effects produced by injecting different doses of triamcinolone acetonide into various parts of the same lesion. Large lesions were chosen to permit such injections and to allow untreated parts of the same lesion to be used as the control. The doses,<sup>*</sup>suspended in 1 cc. volume and diluted with saline when necessary, varied from 10 mg. to 0.07 mg. Photographs were taken approximately once weekly. No local treatment was permitted throughout the course of the experiment, and all patients were hospitalized. In most instances the area of clearing was roughly proportional to the concentration of triamcinolone acetonide injected into different parts of a lesion (Figs. 1 and 2<i>b</i>).† The factor which limited the upper dose was the appearance
Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock protein 70 in signal transduction during hepatocyte ischemic preconditioning (2004)

The results demonstrate that preconditioning induces a rapid activation of P44/42MAPKs and PKC activation plays a pivotal role in the activation of P44/42 MAPKs pathway that participates in the preservation of liver cells. HSP expression is regulated by signals in PKC dependent P44/42 MAPKs pathway.